College of ^fjpsficiang anb ^urgeong Digitized by the Internet Archive in 2010 with funding from Columbia University Libraries http://www.archive.org/details/manualforpracticOObrya A MANUAL PRACTICE OF SURGERY. BY THOMAS BRYANT, F.K.C.S, MEMBER OF THE COUNCIL AND COURT OF EXAMINKKS OF THE ROYAL COLLEfiE OF SURGEONS; SENIOR SURGEON TO, AND LECTURER ON SUROKRY AT. GUV'S HOSPITAL; MEMB. CORRESPOND. DE LA SOClfiTE DK CIURURGIE 1)E PARIS. WITH SEVEN HUNDRED AND TWENTY-SEVEN ILLUSTRATIONS, FOUKTH EDITION, THOEOUGHLY REVISED. PHILADELPHIA: HENRY C. LEA'S SON & CO. 1885. -^ xT William J. Doenan, ^^ESTC■OTT & Thomson, Philadelpbui. AMERICAN PUBLISHERS' NOTICE. American surgeons have unmistakal)ly signified their appreeiation of Mr. Bryant's Practice of Star/crt/ by demanding four editions sinee 1879. The tJiird Ameriean edition, like the second, was reprinted from the third English edition, and in order to cover the advances in Surgery made in the interval, it was subjected to a very thorough revision by Dr. John B. Roberts, a former pupil of ^Ir. Bryant. It has been thought well to reprint the fourth English edition without alteration, since it comes fresh from the pen of the Author, and it may be noted that he has seen fit to accept many of Dr. Roberts' additions. The two volumes of the English edition have been arranged to occupy one iu the American reprint — a change which conduces both to convenience in hand- ling and comfort in reading. November, 1884. PREFACE TO SECOND EDITION. A SECOND EDITION of this manual having been called for, I have availed myself of the opportunity to make some alterations in the substance a-s well as in the arrangement of the work, and, with a view to its improvement, have recast the materials and revised the whole. I have also, to make the work more com- plete, added much new matter, including chapters on diseases and injuries of the eye and ear, some remarks on dental surgery, on the diagnosis of ovarian tumors, and on deformities, together with at least one hundred new wood-cuts. I am well aware that I have foiled to realize in the execution of mv ta.-k the ideal standard I at starting proposed to myself, and I knew, when I first under- took to write the book, how difficult it was to compress the treatment of the vast range of subjects included under the title of "Surgery" into one volume, but mv object was to oifer such an epitome of the main princi])les and methods of practice as should be serviceable to the student and practitioner ; and from the recej)tion the first edition of this work, published in Xoveml^er, 1872, has met with in Creat Britain and America, I feel justified in saying that I have not failed in the attempt, and that the book supplied a want felt by the professional public. To the many reviewers who have acknowledged my labors so fairly and so fully my thanks are clearly due, but still more to the profession, which has wel- comed my humble services so kindly. Fully alive, therefore, to the generous appreciation of my past Mork, and assur- ing my readers that no pains have been spared to bring the present up to as high a standard as my time and opportunities have allowed, I submit it in all confidence to the kind consideration of my professional brethren as no unworthy exposition of modern British surgery. In its execution I have endeavoretl to acknowledge on all occasions the claims of othei*s and whatever merit or novelty may attach to their views or operations, V vi PREFACE TO SECOND ELITIOX. for mv w\:^h has been to represent not so iniu ii iny tjwn opinion, as the position of surgery at the time I write. It Kiilv remains for me to express once more my obligations to Mr. Thomas Turner, the treasurer of Guy's Hospital, by Mhose kindness the materials in the unrivalled collections of that institution were placed at my disposal ; to my col- leagues, Drs. Moxon, Goodhart, and Purves, Messrs. Howse, C. Higgens, and Moon ; and to Mr. Wesley, the artist who has so ably illustrated these pages. Since I first undertook this work deatli has deprived me of two colleagues, Mr. Poland and Dr. Phillips, lioth nf whnm rendered me many friendly services and much valualjle assistance. I refer to their names with gratitude and regret. 53 Upper Beook .Street, GR0i5VEX0R SquARE, March, 1876. CONTENTS LIST OF ILLUSTRATIONS. INTRODUCTORY CHAPTER. Definition of Surjfery— How to Investigate a Case — Points for Inquiry in Surirical Cases li CHAPTER I. Wounds — Repair — Inflaininatiou — Abscess — Sinus and Fistula— Ulcers and Sores— Bed-sores — Mortification — Hospital Gang-rene— Erysipe- las— Krytheina— Traumatic Fever — Septictemia and Pyieniia— Hectic Fever 23 FIG. PAOE 1. riacoid cells 26 2. Diagram illustrating the process of re- pair 27 3. Irrigating apparatus for washing wounds 33 4. The interrupted suture 35 5. The continuetl suture 35 6. The twisted suture 36 7. The quilled suture 36 FIG. FAiiE 8. The button suture 36 9. Leiter's metallic coil for heat or cold . 49 10. Pus-corpuscles 68 11. Abscess knife 69 12. Sinus scissors 72 13. 14. Tliermographs of erysipelas ... 85 15. Thermograph of pytemia 92 16, 17, 18, 19. Thermographs of traumatic fever 92 CHAPTER II. Animal Poisons— Poisoned "Wounds — Insect-sting-s — Hydrophobia— Glan- dcr.s — Malignant Pustule, or Charbon— Syphilis— Inoculation and Syphilization— Vaccine-Syphilis 100 20. Anatomical tubercle 101 23. Hereditary syphilis 116 21. Bacilli from charbon 108 24. Syphilitic" teeth 117 22. Syphilitic deposit in testicle 112 25. Healthv teeth 118 CHAPTER III. Tumors : Innocent, Semi-Malignant, Tumors— Cysts— The 3Iicroscopical 26. Fattv tumor 126 27. Diffused lipoma 126 28. Molluscum fibrosum . 127 29. Fibrous tumor 128 30. Enchondromatous tumor 128 31. Adenoid tumor 129 32. Sarcoma of bone 131 33. Melanotic sarcoma 132 34. Epithelial cancer of stump 136 35. Rodent cancer 1.37 36. Colloid tumor of breast, with section • 138 Cancerous— Cancer— Granulation Anatomy of Tumors 120 37. Fungating follicular tumor 141 38. Serous cyst of neck 142 39. Sebaceous tumors and horn in scalp . . 145 40. Microscopical anatomy of osteoma, en- chondroma 148 41. Ditto, adenoma 149 42. Ditto, lymphoma 150 43. Ditto, sarcoma 151 44. Ditto, myxoma 152 45. Ditto, carcinoma 153 Vll viii COSTEXTS WITH LIST OF ILLUSTRATIONS. SURGERY OF THE CUTANEOUS SYSTEM. chaptp:r IV. Contusions— Arrow AYoxiuds— Burns and Scalds— Skin-grafting— Chil- blains— Frostbite— Boils— Carbuncle— AVarts— Moles— Corns— Bunions — IngroAVu Toe-Xail—Onycbia—Elepliantiasis— Parasites 1 Jo FlCi. PAGE FIG. PAGE 46. Eib pierced bv arrow 157 56, 57. Growth of black skin when grafted 47. Axillary cicatrix after burn 161 on sore of white man 166 48. Mode of applying extension after its 58. Bunion 174 division ." 161 59. Toe-cap for cure of bunion 1.4 49. Effects of burn on neck 162 60. Ingrown toe-nail 176 50. Cheloid of Alibert 163 61. Acute onychia 176 51. Cheloid of Addison 163 62. Chronic onychia • •. ^1^ 52. Congenital cicatrix of lip, nose. etc. . . 163 63. Horny growth beneath nail 177 53. 54. Cicatrization of sores by skin-graft- 64. Ungual exostosis . 177 ing '. 165 65. Elephantiasis Arabum before operation . 178 55. Scissors'^ for skin-grafting 165 66. Elephantiasis Arabum after operation . 178 I 67. Guinea-worm bleb 179 SURGERY OF THE LYMPHATIC SYSTEM. CHAPTER V. Inflammation of the LjTiiphatics and their (ilands— Diseases of the Thyroid Gland 181 68. Exophthalmic goitre 185 70. Microscopical appearance 'of thyroid 69. Pedunculated thyroidal tumor .... 187 , glands 187 SURGERY OF THE >'ERYOUS SYSTEM. CHAPTER VI. Injuries of the Head— Contusions and Wounds of the Scalp— Blood Tumors— Ostitis— Injuries of the Cranium— Concussion of the Brain —Injuries of the Brain and its 3Iembranes complicating Fracture- Compression of the Brain— Encephalitis— Trei)hining— Diseases of the Scalp and Cranium— Trismus and Tetanus— Delirium Tremens— Shock and CoUapse— Feigned Disease 189 71 Gutter-Shaped fracture of skull .... 192 77. Extravasation of blood between bone 72. Saucer-shaped ditto 192 and dura mater 202 73. Comminuted fracture of skull .... 193 78. Section of skull, with cranial contents. 203 74. Fracture of base of skull 194 79. Hernia cerebri 206 75. Fracture of anterior fossa of the base of 80, 81, 82. Operation of trephining ... 212 the skull 196 83. Meningocele at root of nose 2L 76. Punctured wound of skull 196 , 84. Encephalocele . 217 I 85. Necrosis of frontal bone 218 CHAPTER VII. Injuries and Diseases of the Spine— Spina Bifida— Concussion— Intra- spinal Inflammation— Spinal Paralysis after Concussion— Fractures and Dislocations of the Spine— Wounds and Sprains— Curvature of the Spine— Injuries and Diseases of the Nerves— Xeuralgia, Tic Douloureux— Neuroma 229 86 Dissection of spina bifida 229 I 91. Dislocation of spine forward 238 87 Double spina bifida 230 92. Fracture of spine 238 88. Cured spina bifida 230 93. Fracture of spine and displacement 89, 90. Congenital coccygeal tumors . . • 232 i backward 238 COSTKSTS WITH LIST OF 1 LLrsTIiATIOSS. IX CHAPTER \ \\.— 0>,it!nu,J. FIO. I'Ai.K 94, 95. Lateral curvature of spine .... *244 96, 97. Anj;iil;ir curvature of .-.pine . . . 24") 98,99,100. Disrasi- ot rervical vertebne . 240 101. Synostosis ol" ribs to vertebra' .... 247 102. Kif^id spine of spinal disense .... 247 10.'}. Child suppiirtint^lMMly in spinal disease. 247 104, 105. Sa_vre'sapi)uratus for spinal curva- ture 247 CILMTHll VIII. Tlie Kyo I']xaiM!iiatioii of tlio Hall At'CiuniiHulatioii -.\<'nt«'iH'ss aiiis<'as<'S aii64 150. Weiss's double pad for pressure . . . 364 151. Coles' pad for elastic pressure .... .364 152. Dix's mode of compressing artery . . 368 153. Different operations for aneurism . . 369 154, 155. Collateral circulation in the lower extremity after application of a lig- ature to external iliac artery . . . 374 156. Different forms of arterio-venous an- eurism 374 157. Aneurismal varix of axillary vessels . 375 158. Cock's case of arterio-venous aneurism. 376 159. Cirsoid aneurism of temporal artery . 377 160. Cirsoid aneurism of foot 377 161. Degenerating nsevus 378 162. Mode of ligating nievus 379 163. Effects of nsevus of upper lip .... 379 164. 165. Modes of ligating large ni¥vi . 380 166. Needle for applying subcutaneous liga- ture to na'vus 380 167. Application of ligature to artery . . . 382 168. Best form of aneurism needle .... 382 169. Incision for ligation of aorta or com- mon iliac artery 383 170. Operation of ligating common carotid and facial arteries 386 171. Operation of ligating the subclavian and lingual arteries 389 172. Lisation of axillarv arterv 390 173. 174. Lisation of brachial'arterv . 390, 391 CONTENTS WITH LIST OF ILLUSTRATIONS. CHAPTER X.— Confinued. 175. Ligation of radial artery (upper third) . 392 176. Ligation of radial and ulnar arteries . 392 177. Ligation of external iliac and femoral arteries 393 178. Ligation of posterior tibial artery . . 396 179. Ditto behind malleolus ....'... 397 180. Ligation of anterior tibial artery . . 397 181. Ligation of dorsalis pedis 398 CHAPTER XL Injuries and Diseases of the Veins— Venesection 182. Obstruction of inferior vena cava . . 403 I 184, 185. Venesection 183. Varicose veins 404 | 398 407 SURGERY OF THE DIGESTIVE ORGANS. CHAPTER Xn. Affections of the Lips, Mouth, Tongue, Pahite, and Tonsil 409 186. Congenital fissure of lower lip and jaw. 187. Formation of upper jaw 188. Central fissure of lip 189. 190,191. Degrees of single harelip . . 192, 193. Double harelip 194. Position of [)atient for operation of harelip 195. Operation for single harelip 196. Hainsby's truss for harelij) 197. 198. Collis' operation for harelip . • 199. Malgaigne's operation 200, 201. Operation for double harelip . . 202, 203, 204. Tiie same with projecting in- termaxillary bones 205, 206, 207. Cheiloplastic operations ibr deformed mouth 208. Cancer of lower lip 209, 210. Operation for formation of new lip .• • 211. Hypertrophy of mucous glands of lip . 212. Hypertrophy of lip 409 213. 409 214. 409 215. 410 216. 410 217. 218. 411 219. 411 411 220. 412 221. 412 412 222. 412 223. 224, 412 226, 413 228. 413 229. 414 230. 414 231. Cancrum oris 415 Ranula or sublingual cyst 416 Salivary calculus 417 Submaxillary tumor 418 Ichthyosis of tongue 422 0})eration for removal of tongue . . . 431 Different operations lor removal of tongue 431 T. Smith's gag ._ 432 Fergusson's knives for operations on palate 432 Paring edges of fissured palate after introduction of sutures . . . . 433 Needles employed in fissured j)alate . 433 225. Operation for fissured palate . . 434 227. Fergusson's operation on hard palate 435 Trendelenburg's tracheal tampon . . 436 Tonsil guillotine 437 Operation on tonsil with guillotine . . 438 Kemoval of tonsil with knife .... 438 CHAPTER XIIL Diseases of the Gums, Jaws, Teeth, Pharynx, and CEsophagus- Surgery— Affections of the Pliarynx and (Esophagus .... 232. Necrosis of lower jaw with condyloid process 440 233. Fibrous epulis from gum 441 234. Epulis springing from bone 441 235. Tooth odontome 441 236. Odontome after removal 441 237. The same in section 441 238. Dentigerous cyst of u^jper jaw with tooth 443 239. The same of lower jaw 443 240. Dentigerous tumor of upper jaw . . . 444 241. 242. Enchoudromatous tumor of upper jaw • 243, 244. Lines of incision for removal of upper jaw ■ • • _ 245. Saw for operation on jaw 246. Lion forceps for the same 247. Periosteal sarcoma of lower jaw . . . 248. Fibro-cellidar tumor of lower jaw . . 249. 250. Fibro-cystic disease of lower jaw. 251. Dislocation f)f lower jaw 252. Reduction of dislocation of lower jaw. 253. 254. Bandage and splint for fracture of lower jaw 451 -Dental 444 445 445 445 446 446 446 449 449 255. Thomas' mode of adjusting fracture of lower jaw 256. Moon's interdental splint 257. Metal caps for the same 258. Hammond's wire sj)lint for fracture of jaw .... . ........ 259. Hammond's wire splint applied . . . 260. Vertical section of tooth 261. Development of lower molar tooth . . 262. Odontoplastic odontome 263. Radicular odontome 264. Dentigerous cyst not involving antrum 265. Denticle 266. Defective teeth 267. Pointed teeth 268. Child's jaws, showing the development of tiie })ermanent teeth 269. Mouth mirror and searcher for exami- nation of teeth 270. Progress of decay in teeth 271. Rhizodontropy 272. Pivoting with vent 273. Manner of holding tootii forceps . . . 439 451 452 452 452 452 454 454 456 457 457 458 459 460 461 468 470 470 470 476 CONTENTS Wrril LIST OF ILLI'STIIATIOSS. XI CHAPTER \U{.— Co,itinur,l. PIO. I'AUK , Vm. PAOE 274. Stump lorieps 477 | 278. Qisoplia^eal bis(M'ra— Abnormal Anus, F<'<'al Fistula— FoiUMj^n liodios in tli«" Sttnnacli and lnt<*stiiuvs — (ilastrotoniy anil Ciastrostoniy — Intestinal Obstruction — AtMitc Internal Stranj;ulation of tlie liowel — Intus- susf«'ptions — Laparotomy — Fiit<'rotoiny — Colectomy— Colotomy—Kx- eision of the l*yb>rus— Tap|nn}.r tlu' Intestine— Tapping- the Alulo- n»en— Hy I >«'|»osits — l{«*nal <'al- i-uli Lit lioiil i-i|i( i«-s Lit li<>toMi.\ Lit hot rit > S«>iii-<-«'s 4»t' I>ifli<-ult> in ljtliotoMi>, and li<»\v to A\oi4l tlwin <>lli«-i- <>|MTations ('ans<-> of l>4-alli al't iii th<* l-'cinah* ItlatlUcr — Forci^^n HtMlit'S in the IthMlth'i* r>.")l FUi. 368. 3»)<.t. 37(1. 371. 37 J. 37:?. 374, o<0. 377. 378. 379. 380. 381. 382. 383. PACiE FKi. Kpitluliiiiii rri'iii iiriiiiuv passages . . Col 384, S|(«.Tiii:itiizn:i iiiul \a;ri":»l epillioliiiiii . (iol 386, riiiiaiv I'a.sts iseases of the Testi<'le — Inflammation of the Testicle — Epididymitis— Orchitis— Tubercular Disease — Hernia— Cystic Disease — Cancer— Scrotal Tumors— Castra- tion — Varico<*ele— Affections of tlie Scrotum— < Edema — Eleplianti- a.sis—Canc«'r— Sterility— 3Iale Impotence and Spermatorrluea ... 411. Operation for phimosis 7('8 412. Circumcision i first stej)! 709 413. Operation for paraphimosis 709 414. Stump after amputation of the penis by Hilton's method 710 415. Corpus spongiosum projecting from urethra after injurv 711 416. Ectoj>ion vesica- in male 417. The same in female 418. Perineo-scrotal hypospadias 419. B, c, D. E. Operation for perineo-scro- tal hypospadias 420. Encysted hydrocele of cord 421. Tapping hydrocele 708 ri2 -1 o rii ri3 r2.5 •26 xiv CONTENTS WITH LIST OF ILLUSTRATIONS. CHAPTER XXlX.— Contunmf. no. PAGE FIG. PAGE 422. Mode of suspending testes with hand- 426. Strapping testicle 749 kerchief 735 427. Testicle in perinaeum ... ... 750 423. Hernia of testis following tubercular 428. Varicocele 750 disease 741 429. Morgan's suspender for varicocele . . 751 424. Cystic disease of testicle 743 430. Elephantiasis of scrotum 752 425. Cancer of testicle 744 CHAPTER XXV. Surgical Affections of Female Genitals— AVoiinrts— Adherent Labia— Viilviti.s — Xonia — Xnevi — Hernia— Labial Absce.sse.s — Labial Cysts — Tumors — Cancer — Lupn.s — Syphilis- Imperforate Hymen— Enlargred Clitoris — Clitorirtectomy — Kiipture of the Peiinteum — Prolapse of Uterus— Vesico- and Ilecto-Vaj^inal Fistulae 756 431. Central rupture of the perinaeum . . . 758 ! 435, 436. Mode of paring edges of vaginal 432. Operation for ruptured perinaeum . . 759 fistula 761 433. Position of patient for operation for 437. Introduction of sutures in vaginal fis- vesico- vaginal fistula 761 tula 762 434. Self-retaining speculum for the same . 761 438. Speculum dilator for female urethra . 763 CHAPTER XXVI. Diseases and Tumors of the Breast— Inflammation— Mammitis— Mam- mary Abscess — Induration —Tumors— Hypertrophy —Cancer — Cystic Tumor— Galactocele 763 439. Submammary abscess 766 446. Cystic tumor in breast with intra-cystic 4r40. Adenoid tumor of breast dissected . . 769 growth 774 441. Cystic adenocele 770 447. Cystic carcinoma 775 442. Solid adenocele 770 448. Section of sarcomatous tumor of breast. 776 443. Hypertrophy of breast 770 449. Open cancer of breast 776 444. Section of infiltrating cancer 772 450. Excision of breast 779 445. Section of tuberous ditto 772 CHAPTER XXVII. Ovarian Disease and Ovariotomy— Hysterectomy 780 451. Trocar and eanula for tapping ovarian ' 453. Omental clamp forceps 789 cyst with sliding forceps 788 454. Tait's clamp for hysterectomy .... 793 452. Nelaton's cyst forceps 788 , THE SURGERY OF THE MUSCULAR AND OSSEOUS SYSTEMS. CHAPTER XXVIII. Affections of the Muscles and Tendons— Contusions— Compound Lacer- ation—Dislocation of Muscles and Tendons— Rupture of Tendons- Wounds of Tendons— Inflammation of Muscle— Atrophy of Muscle- Writer's Cramp— Tumors in 3Iuscle— Ossification of 3Iuscle— Rider's Bone— Tumors of Tendon— Inflammation of Tendons— Affections of BursiB Mucosae, Synovial Cysts, Ganjflion 795 455. Rupture of rectus femoris 795 | 463. Semi-solid bursa 805 456. Thumb torn out 796 464. Bursa sloughing from over patella . . 805 457. Ruptured long tendon of biceps . . . 797 465. Compound ganglion of hand and fore- 458. 459. Chronic inflammation of muscle . 799 arm 810 460. Instrument for writer's cramp .... 801 466. Lipoma of the palm simulating gan- 461. Rider's bone 803 glion 811 462. Cancerous tumor of hand 803 coyTKyrs with list or ii.i.rsTiiATioys. XV CIlAl'TKIt \\l\ Ortlioi»;i'(li«- Siiryorv " (Out rai-t ion of tii«> l''iii;;«'r.s lti;;i«| Atrophy — N\r\-\«MU 811 H... fAi.K KKi. ,.A(iE 4()7. Types of tlie (lifleioiit kimis ol" (li-ri. nil- 47"). Little's slioe for talipes 819 ilies of the li:mii>. aiul leet .... SlU -17»). iMvies-CJollev's splint for talipes . . . 81U 4().S. Talipes e<|iiiniis SU 177. K.xtreiiie e.xuinple of talipes e<|iiino- 4(J'J. ('oii>;eiiital varus SI 1 varus H20 470. Etpiino-varus .si') 47S. The same jls remedied by operation 820 471. Talipes valgus, cou^^eiiital and ac- 47'.). Portions of bone removetl S20 i|uired S].") 4S0. Spurious talipes val;;us ...... S'Jl 47"J. Talipes oaleaneus, eon<;enital and ac- 4Sl. O^^ston's operation for j^enu valjjum S2'2 ipiired SKi 48"J. Limh before and after Macewen's ope- 47.). Mode of stretehing tendons by .strap- ration 822 piuic •*^17 483. ('ap and band for extension in wry- •174. lUahanau's splint for talipes .... 817 neck 824 CHAPTER XXX. Sprains— Contu.sioii.s and AVotiiid.s of Joints — Dislocations— Soparatioii <>f Kpiphysi's— Conj-renital 3Ialforiiiatioiis of Joints 825 484. False joint alter dislocation of head of 5U4. fenuir 827 485. Dislocation of sternal end of clavicle forward 486. Dislocation of scapula 487. Dislocation of heaiphysis of femur 913 603. Apparent elongation of lower extrem- ity from oAduction of fenuir . . . 914 604. ^6ducted lower extremity in hip dis- ease 914 605. Apparent shortening of lower extrem- ity from ac/duction of femur . . . 914 606. ylc/ducled lower extremity in hip dis- ease 914 607. Displacement of femora on dorsum from disease — front view .... 608. The same — side view 609. Lordosis in hip disease, with patient erect 610. The same patient — lordosis eflfaced . . 611. Lordosis in hip disease, with patient standing 612. The same — remedied 613. Position of lower extremity in ne- glected hip-joint disease 614. Synostosis of hip-joint 615. Arrest of growth in neck of femur fol- lowing articidar ostitis 914 914 915 915 915 915 915 916 916 CONTENTS Willi LIST o/' I l.l.ls'li:ATI()NS. xvn ("IIAITKK XX KKI, 1-A(.K (ilti. Apiifuraiici' of kiiri'-joiiU in synovitis . '■)! (>17. Aiipi'iiranco of kiu'c-inim in articular ostitis it 17 t>lS. Appi-aranri' ol' foot at'irr ri'inovai of scaplioiil, fiilioitl, ami tliiiT cnnei- forni l)ont's 918 ()19. AiMonnt of Ik'xioii in t-lliow afti-r re- coviTv from tiist-aso it'JO t)'20. I)()nl)!c splint as appliod in hij) disoasf !)'J"J 621. Thomas' posti-rior splint lor hip ilis- c-asf 9-J2 (i22. Ik'ad of foniiir altnvd liy disease . . !>2o ()2;}. linniovahk- splint for hip discasi- . . 1)24 624. Modi' of applyint;- vxtonsion to lower extremity in hip disease 1124 625. Anehylosis of hip-joint at ri^dit angles 1(24 626. Position of lind> after Adams' opera- tion 924 627. Instruments employed for subeulane- ons division of nei-k of thigh-l)one 925 628. Line of seetion of neek of thigh-hone in Adams' operation 925 629. Splint for diseased knee-joint .... 926 (i.SO. Thomas' knee splint . ". 92(> ().'>!. The same — applied 926 .X I I. — ( 'onlinittd. 7 6:52. 6:i3. 6.S4. 6:^5, 6.>C>. 637. 638. 639. 640. 641. 642. 643. 644. 645. 646. 647. PAOK Ilavarian splint, as rompleted for dis- eii.se of knee 927 CJowan's exeision saw 931 Abscess in liead of tiFiia with necrosis, hnrrowing into knee-joint .... 9.33 Splint for excision of knee 936 Foot after removal of aslraf^aUis . . . 9.37 Abscess cavity witii secpiestrnin in head of humerus 938 Parts removed by resection of elbow- joint . . . ". 939 Necrosis of head and neck of radius . 939 Vertical incision for excision of elbow- joint 940 Splint for excision of elbow 940 Section of loose cartilage removed from knee-joint 943 Microscojiical appearance of loose car- tilages 944 Osteo-arthritis (jf knee-joint 946 Osteo-arthritis of head of tibia . . . 946 Changes in hip-joint tlie result of osteo- arthritis 947 Ankle the seat of osteo-arthritis . . . 947 CHAPTER XXXIII. l)isea.s«'s of tlu* Bstitis and Endos- titis — NocTosis— Caries — Tumors — Osteitis Deforniaiis 949 648. Superficial necrosis of frontal bone fol- lowing wound caused by gnawing of a ferret ". ". . . . 950 649. Periosteal necrosis of tibia following periostitis 950 650. Necrosis of shaft of tibia resulting from endostitis, with shell of new bone surrounding it 950 651. Necrosed leg, with probes inserted into cloaca^ leading to dead bone . . . 950 652. Necrosis of shaft of tibia 951 653. Necrosis of articular lamella of bone . 951 654. Sclerosis of bone 952 655. Abscess in head of tibia 954 656. New bone formed beneath periosteum resulting from periostitis .... 955 657. Upjier iialf of humerus separated from upper epii)hysis thrown oft" by nat- ural processes 958 658. Instruments employed in operation of se(iuestrotomy 959 659. Arrest of growth in til)ia after removal of necrosed shaft 960 660. Hollow in face after escape of bony tumor ".962 661. Tumor as discharged 962 ()62. Exostosis of femur, with section . . . 963 663. Periosteal exostosis 963 6t)4. Enchondromatous tumor 964 665. Enchondromatous tumors of hand . . 964 iSiS^. Periosteal sarcoma 965 667. Osteo-chondroma of fennir 965 668. The above during life 965 669. Myeloid disease of femur 966 670. Myeloid tinnors of bone 966 671. Cancer of shaft of femur with frac- ture 966 672. Periosteal cancer of tibia 967 673. Osteoid cancer of bone 967 674. Epithelial cancer attacking bone . . . 967 675. Cancer of skin invan arrived at by a jtre,ccss of elimination ; each possibility should be separately considered and iceighed, and the most j)robable Jinally accepted, a diaffnosis wholly framed on probabilities being most hazardous. 2 17 1 8 INTR OD UCTION. For example, a tumor at the femoral ring may ^>o.s>- //>(// l)e either an aV).scess, an aneur- ism, a varix, cyst, hernia, enlarged gland, or a new growth. An abdominal tumor may be ovarian, uterine, peritoneal, vesical, splenic, f'ajcal, renal, or hydatid. Its probable nature will be best arrived at by eliminating each of these possibilities seriatim after a due consideration of all its clinical symptoms, the most probable diagnosis being finally accepted on evidence both negative and positive. With the above great principle of practice as a guide in clinical investigation, I now proceed to consider how any injury or disease is to be investigated, confining my observa- tions to classes of injury and disease. I do not propose, however, to point out here the exact mode in which it is well to examine a cage or to report it — for a report is only a written examination — although at pages 21-23 an outline will be seen which may prob- ably be found of service. I drew it out many years ago, when surgical registrar at Guy's, where it has been generally followed ever since. How TO Investigate a Case. When a surgeon is callt'd to a patient, his questions naturally apply first of all to the seat of disease or injury. Is it in the head, chest, abdomen, or extreniities ? He will then ask as to its duration or when the injury was received ; or when was the disease discovered? If a case of injury, his inquiries would tend to elicit the exact mode of its production, the force employed, and the character of the instrument by which it was pro- duced ; for these points are of essential importance under all circumstances, and in head injuries they often give the key to the solution of many questions. By these means the exact seat of injury will probably be indicated, and the surgeon will be led to make a close examination of the injured part; but he should never fail to assure himself that all other parts of the body are sound and in working order, and that no other is involved in disease or is the subject of injury ; for it would be a forlorn hope to amputate for a crushed limb when associated with a ruptured liver, or to reduce a dislocated joint when combined with some fatal internal lesion. In a case of injury to or disease of the head or nervous system, the most important point the surgeon has to determine has reference to the exact seat of the affection. Is it confined to the soft parts covering the bone, or are the contents of the skull in any way involved? because, in the former, the affection is comparatively of small importance; whereas, in the latter, its gravity cannot be too highly estimated. Scalp wounds, however severe, have, as a rule, a successful ending; whilst brain injuries, however trivial, should always be regarded with apprehension, for they may lead to the most serious complications. When no signs of brain disturbance after an injury have been observed, the diagnosis is not difficult ; for without symptoms, local or general, a surgeon may be excused from entertaining the idea of brain complication, although he should know that cases of frac- tured base have taken place without any symptoms to suggest the presence of such an injury. AVhen indications of brain disturbance exist, the difficulty arises; for it cannot be too firmly impressed on the student's mind that the same symptoms may be produced by concussion as by compression of the brain, and that bone pressing on the brain, and blood effused upon its surface or within its structure, give rise to precii^ely the same phe- nomena ; he should know that the symptoms produced l)y apoplexy the result of a rup- tured vessel, and by hremorrhage into the brain from an injury, are almost identical, and that those produced by what is called functional disturbance of the brain closely resemble those caused by organic mischief. Whilst, therefore, it is imperative on the student of surgery to remember that a variety of different conditions may give rise to apparently identical clinical symptoms, he must know that the clinical history of each of these cases will on inquiry be found to differ widely, and that it is to the collateral evidence of the case he must look to find the right clue to a successful diagnosis. Where no clinical history can be obtained, the difficulties of diagnosis are indeed great ; thus, when a surgeon is called to see a man who has been found in the street insensible, who is, in fact, in an apoplectic condition, and has, at the same time, some external evidence of injury to his skull, and may perhaps al.so smell of spirits. The questions that arise in the surgeon's mind under these circumstances are very conflicting. Did this man have a fit and then fall, or are the symptoms due to a brain injury the result of an accident? Was he knocked down and injured, or was the injury the conse- quence of a fall ? Are the symptoms caused by drunkenness, or how far are they com- plicated with it ? Are they the result of blood-poisoning from kidney disease, or poison- ing by opium ? ISriinDrcTlos. 19 To unravel all tlicso jmitits <;rfat caic and iliMiiminatiiiii art" n'i' hcstowcil upon tlu- task, hecaust- to treat an apoplectic seizure or u case of severe brain injury Ironi external violence tor drunkenness is a j;rave error; hut, unfortunately, it is one whi(di is not unconinion. To mistake drunkenness for apoplexy or severe head injury is, perhaps, a less jrrave, althoujrh it is, without doubt, a serious, fault. As a matter of policy, however, it is L'enerally a wis*' rule to rej^ard all these .su.s- ]>icious cases from the more serious point of view, and to watch and wait for }«vmptom.s to indicate the ]»ractice that should be pursued. What I wish, therefore, to imj)res8 upon the student is the necessity of bearing: in mind that all these different conditions alluded to prc^^ent to the sure in operation, the history of the case will probably form a true guide to the surgeon, ami in the latter some local injury to the nerves .supplying the part, .some tumor or atieurism pressing upon the nerves, will probably be found ; or percliance it may be a case of lead palsy or infantile paralysis. But, under any circumstances, a true diagnosis can only be made by eliminating from consideration the many possible causes and adopting the most probable. Again, if ahoiild be an invariable riih- of practice in every case of injury or ili^ase to compare tin- sound vith the affected sid<: of tlu- body. In the diagnosis of a dislocation or fracture, the information gained by the comparison often furnishes at a glance to tlie experienced eye a true suggestion as to tlie nature of the accident, and in joint disease any effusion into a joint or enlargement of the bones is. as a rule, readily detected. The nature of the disease or injury being thus suggested to the mind througli tlie eye, the suggestion remains to be confirmed or corrected by a careful manual examina- tion, by the other clinical symptoms, and by the history of the case, the facts elicited by the sight, by the liand. and by the ear being made separately available, and the conclu- sion drawn after a careful balancing of the probabilities and possibilities of the case. The diagnosis will be well established when all these different modes of investigation lead to one conclusion. In surgery, as in medicine, tlie student must educate the eye to see and the hand to feel, and the task is by no means .simple or easy ; indeed, it is one of the mo.st difficult to learn, and cannot be begun too early in his professional career. Reading will not help, nor thought aid: personal experience at the bedside alone will supply the want. To recognize the existence of a wound or the deformity of a broken bone may not be difficult, but to read aright the endless phenomena which a wound presents, and to make out the character or tendency of a fracture, require much experience. To .see that a swelling exists in a part is open to the uneducated eye. but to recognize the various aspects that different tumors assume, to make out their form, position, and attachments, to estimate their consistence, to recognize the fluctuation of fluid, whether superficial or deep, and to detect pulsation, require considerable tactile pf)wer and long education. What education alscj is demanded in order to read the phenomena presented in diseases of the eye or the skin ! '' No study of the written observations of others could enable any to appreciate those endless varieties of the pulse which entirelj" bafile description, or to distin- guish between the warmth of the skin excited by various accidental causes and the pun- gent heat accompanying the first stage of pneumonia, or acquaint him with the .shrunk and shrivelled features derived from the long-continued disease of the abdominal viscera, the white anil bloated countenance often attendant on changes in the functions or structure of the kiilney. the squalid and mottled com])lexion of the cachexia dependent upon the united effects of mercury and syphilis, the pallioiitaiieous haMimrrliajres arc most likely to occur." In this disease, thorctbre, ho advises a mercurial and saline jiurjie (.'Very three weeks, dry food, with a considerable j)orti(»n nt" dry lihrinoiis meats, and plenty nf open-air exercise, ^jreat care heinir fthserveil to avoid injurit.-s. The bleeding;, as a niU;, ceases .spontaneous! v. In the ae<|uired disease iron is of threat value. Cachexise. — D" they exist? I.s there any drtinite aspect associate*! with any tleliiiite disease? Is there a eancerou.s cachexia? I have little hesitation in statin;^ that in practice no such tiling can be established, and that a larL'e number of patients suHcr- ini^ from cancer are as healthy-lookinir as any other (;lass. if not often healthier. There can be no doubt that a patient suilerinir iVom cancer which, by its discharfres or ilevelop- ment. interferes with the important functions of life and undermines his powers, has an anxious, drawn, bloodless, and waxy appearance ; l»ut so has the suVjject of any orfraiiic disease which interferes with the function.s of dijrestion and assimilation, and particularly the subject of intestinal disease. The patient exhausted by suppuration, by .spinal, bone, or joint mischief, the man or woman who from drink, syphilis, or mercury (.separately or coml)ined) is gradually beinf skin. Treatment, etc. DISEASED BONE. — Part atiected ; duration; cause, as external injury, syphilis, mercury; extent; superficial or deep, partial or general ; previous treatment, especially as regards operations. Present Symptoms and Appearances. — Condition of dead bone or s^equeMruin, fixed or loose ; number and position of openings, or external cloactr, with the date of their first appearance. Treatment. — If by operation, its immediate success. DISEASES OF JOINTS. — Part afiected ; date of first discovery; a.ssigned cause, as injury. Note the early symptoms in the order of their appearance, and date of any fresh symptom or marked change; if pain or uneasiness preceded swelling, or was coeval with it ; if the former, how long? Rapidity of progress; previous treatment, and its effects. Present Appearances. — Position of joint ; if flexed, the angle of flexure; size and shape. Character OP Swelling. — Uniform or bulging; nianipular indications, hard, soft, elastic, or fluctuating; mobility, amount; if attended with grating, etc.; in the knee-joint, note if the patella be free or not ; if free, the sensation felt on moving it ; condition of skin ; if fistulous openings exist, their position, number, and character of their discharge ; deep or superficial ; note the date of their first appearance, and if natural or artificial. Pain, acute or gnawing; its position, general or local; if aggravated liy motion or interarticular pressure; if increased at night. Sleep, if disturbed liy crying or starting of the limb ; sympathetic pain, and its position; condition of muscles of limb; constitutional symptoms. Treatment. STRICTURE. — Organic or traumatic ; duration and assigned ca«se, especially as regards gonorrhoea; use of injections, or accident ; if previously treated by catheter; complications, as abscess, fistula, with their position and date of appearance. RETENTION. — Mention period of retention ; preceding symptoms, and cause, as stricture, calculus, {)aralysis, abscess, prostatic disease, etc. Constitutional and local symptoms ; previous and pres- ent treatment ; puncture per rectum, note the date of removal of the canula and arrest of tlie flow of urine through the wound. EXTR.VVASATION. — Cause, over-distension or accident; duration of retention before urethra gave way, and period that elapsed before being seen. Describe the appearances and extent of parts infiltrated ; constitutional symptoms and treatment. VENEREAL DISE.\SE. — Chancre, duration ; position, glandular, urethral, coronal, or frsenal — external, internal, or fringing preputial ; character, indurated, non-indurated, aphthous, raised, excavated, irritable, phageda?nic, or sloughing; tubercle; condition of inguinal glands, indurated or inflamed. Prevloiia treatmenl, particularly as regards mercury. Complications. — Note the date or appearance and situation of each or any of the complica- tions; the order and time of their occurrence after the primary sore. Present appearance and treatment of each. GoNORRHCE.\.^Date of contraction; former treatment, especially as regards injections, copaiba, etc. Complication.s, and their duration; in epididymitis, if following suppressed discharge; use of injections, copaiba, or violent exercise. STONE IN BL.\DDER. — When discovered; date of earliest symptoms; if preceded by the pas- sage of sand; amount of irritability of bladder; character of urine; constitutional and local symptoms. Treatment — litlmtrity or lithotomy; in latter, note any peculiarity ; date of arrest of the flow of urine through the wnund. TUMOR. — Date of its discovery and size; rapidity of growth; general and local symptoms, in their order of appearance. (Jeneral health prior to discovery, and since; hereditary tendency; assigned cause; depressing influences. In mammary tumors, number of children; date of birth of last; if ever suckled with aflected breast, when? condition of the catamenia; if ceased, how long ? Previous treatment, and success. Pre.sent Condition and Appearances.— Position of tumor; size, shape; external aspect and condition of skin; pain, and its character; condition of lymphatic glands; manipular indi- cations ; mobilitv, when in breast, whether moved by traction of the nipple ; feel hard, elastic, etc., etc. Constitutional symptoms. Treatment. — In recurrent growths, give the date of former operations; date when healed, and of its first reappearance and position. DPER.\TIONS. — Describe position, direction, and number of external incisions; the steps of the operation as performed; its duration ; number of vessels tied or twisted, and amount of haemor- rhage. In amputations, the part amputated, and position of amputation. In flap operations, give the position of the flaps ; whether anterior, posterior, or lateral ; whether performed by perforation or external incision. In the c<'nd)ined flap and circular, note the position of the skin flaps; in all note the result and character of stump. LSCl^JJIt W'JlWDS. 23 ("llAl'TKli 1. ON WOrXPS. Ki:i'All{. am> infi.a.mmatmin KkiiM a clitiii-al jioiiit ot" vit-w. wounds may !•(.■ divided intd tlic Open and tluSubCU- ta>neOUS, if «e i-xi'ludt- those liy wliitli uidiiial |ii»is(iiis are iiitrodiiccil into tlic >\-t\ external violence — the result either of accident or. as in an oj»erati(»n. of desifrn — in which there is a solution of continuity in the soft ti.-sues. and in which the deeper parts are exposed to the influence of the air through a more or less ga[»in coSSTirrTloSAL L !' 1' I'J "I'S Ol' ISnsLI) W'Ol'SDS. 2'' 'inilialilv )•<-• nmri' .sensitive, th»' aiiKUint oi' pain vv\\ sulyi-cted. If the e(lf;e.s <»f the wmuihI have lieeii stitehfd toiretlier and the parts are Miiich swnMen and (I'deniatous, tht-re will he tension upon the wuiind and a dis|i(isitiiin to se|iarate and jrape. In a healthv suhjeet, however, when repair jjoes on well, all these loeal phenomena will snhside and disappear in the course of two. three, or lour days, aceordin;; to the; rapidity and perfci-- tion of the healiuL' proei-ss. and a eure will then take j)laee. But should the loeal jdic- nnmenu ahove deseriltetl he more persistent, increase in severity, spread lieyond the niaririns of the wound and surnjundinji parts, or alter in character for the worst;, what has heen a phvsioloirieal ri'parative j»rocess will jtass into a ])athido^ical or di.sea.sed one, and the jiarts will then he saiise for death may subsetiuently he discovered, the lieart's action being suddenly stopped thntugh some central nervous influence. The degree of '-shock" that attends an accident or operation depends, as a rule, upon the imitortance in tlie animal economy of the organ injured, the extent and nature of the violence which the tissues have sustained, the size of the blood-vessels which have been involved, and the amount of blood which has been lost. A patient in good health will bear a severe wound or operation with little shock ; while another with di.seased viscera, and more particularly with diseased kidneys, will be subjected to severe .shock from even a trivial injury. The age and constitutional condition of the patient have an important influence under all circumstances. "Reaction." — When what has been described as the period of '-shock' after an acci'lental or opeiative wound has passed away, the stage of " reaction " is readied; and in a general sense it may be assumed that the intensity of this stage is fairly governed by the intensity of that whicli preceded it — that is to say, where there has been little shock there will be but feeble reaction ; and where the .shock has been severe or prolonged the stage of reaction will be of a like type. Still, this rule^as innumerable exceptions, and these exceptions seem to depend more on the individual peculiarities of the patient than anything else: one person, after a slight injur}' or operation, experiences little .shock, but sliarp reaction ; while another, suff'ering from a severe injury or operation, will have a prolonged stage of .shock, followed by no more reaction than seems to be neces.sary to restore the circulation to its normal condition, and to allow the functions of the body to work efficiently. Children and women and the subjects of neurotic tendencies always react rapidly and in a marked way from all kinds of shock, whether mental or physical ; but, as a rule, they do well. The rigors, nervous trenil)lings, and fears which are often met with in nervous stibjects after operations, and which often cause alarm, are but rarely followed by any bad results. The si/iitj>foni:i of reaction, in their mildest expres.sion. are simply those of the restora- tion of the circulatory and nervous functions to their normal condition, the heart, with the circulation generally, so rallying from the dejiressed condition into which it has been thrown by the - shock " of the accident or operation as to come up to the usual standanl of health, and the nervous system so recovering from the temporary state of depression, if not of uncon.sciousness, into which it has been cast as to resume its normal power of governing and controlling the actions of the body over which it presides. The reparative process, conse(|uently. under the.se circumstances may be expected to go on uninter- ruptedly to a successful issue. The w(jund will undergo repair and heal, and the subject of the wound will suflfer little or no constitutional evil beyond that occasioned directly by the injury. The stage of reaction in a clinical sense will then be normal ; it will be such as may be sai'l fairly to balance tliat of shock, and to tend toward recovery. Traumatic Fever. — "When the symptoms of reaction, either with respect to inten- sity or duration, exceed the normal standard : when the circulatory system acts power- 26 PROCESS OF REPAIR IN WOUNDS. fully and rapidly, the respirations increase in quickness, the brain and special senses become abnormally active, and the temperature of the body rises and remains above that of health ; and when with this elevation of temperature the functions of the body gener- ally are disturbed and work badly, as indicated by thirst, a foul tongue, loss of appetite, constipation, diminished secretion of urine, want of sleep, or disturbed rest, — " traumatic fever" is said to exist. This fever may show itself the day after the injury or operation or may not appear till the second day, and it may last for twenty-four, forty-eight, or seventy-two hours. When the case is going on satisfactorily toward recovery, the fever seldom lasts beyond this period. Should the symptoms, however, continue, dangers are to be apprehended and difficulties looked for. When the fever runs on into the fifth or sixth day, the sur- geon may be sure that some complication is present ; and should the symptoms be still more fixed, the probabilities are that the case is not only badly complicated, but that it will pass on to a fatal issue. Temperature Chart. — Under all circumstances, and in the treatment of every wound, accidental or operative, the eye of the surgeon should be steadily fixed on the temperature chart, such a chart aff"ording the surest indication of the advance or presence of any such complication. Process of Repair in Wounds. Before entering into details, it is well to know, as a primary truth, that the processes of repair are identical in all tissues ; that the reparative process in bone or muscle, integu- ment or tendon, soft or hard parts, is the same, such modifications alone showing them- selves as necessarily appertain to the anatomy of the tissue or to the special circumstance of its position. Thus, tissues that are highly vascular may undergo more rapid and more perfect repair than others less fortunately circumstanced, and bone tissue may require more time to unite than skin ; yet in all the process is alike. Let us, therefore, inquire what the process is, and see what changes take place in parts undergoing repair, and then look at them where they are best seen — where an incision is made through the skin and the edges are brought together. The chief points that can be observed have reference to the capillaries. In them, at the margin of the wound, the blood will be found coagulated up to the nearest anastomosis, and the ci^pillary vessels in the neighborhood will be seen to be dilated. This dilatation is caused by the increase of pressui-e to which the capillaries have been subjected by the altered circulation of the blood in the immediate vicinity of the wound. When wounds unite by mimrdiate union, no otfter changes than these take place, beyond the gradual restoration of the capillary circulation through the parts that have been divided ; and under such somewhat rare circumstances no scar or cicatrix is left. The soft parts at first simply adhere together, and subsequently become continuous. Adhesive Lesion. — Should the wound unite by what is called adhesive union or primary adhesion (the " first intention " of John Hunter), in Fig. 1. which a cicatrix is formed, other changes are to be seen ; and these take place in the connective tissue, in which the vessels of the part ramify. They consist of cell multiplica- tion, and under the circumstances supposed we find between the edges of the wound a vast accumulation of cells, filling up in various degrees the spaces of this wounded tissue. It is through these cells that cicatrization takes place. The cells are in part simple nucleated cells, which may be called " em- bryo cells " with connective-tissue corpuscles, and they con- tain a nucleus and nucleoli, Klein's placoid cells (vide Fig. 1). Whether this cell multijilication depends iipon changes in the cell itself, as Virchow affirms, or whether the cells are the white corpuscles of the blood which have escaped by exuda- tion from the capillaries, as Cohnheim would lead us to believe, A Group of Placoids In Different I do not noW Care tO inquire. All admit, however, the multi- wandering. '^°(^//er Gow'V/^/n?*!} plication of cells in the affected tissues (vide Fig. 2). Pro- fessor Redfern writes, " The facts must be recognized : the floating blood cells are really the very cells which once formed the substance of the lym- phatic glands, the spleen, and other organs, and they do in fact move through the walls of the blood passages and wander about freely in what are called solid tissues." When PROCESS OF Hh'I'A/n /.V W'OIWDS. 27 we recolli'i-t Ikiw |i(iitir;ilplc iIm- tissues iif an animal arc, wt- .shall ccaw to be startled at seeintr tlu-m lu-i-Mnu- tin- scat ul' iMitirdy ntw deposits, or timlin^ thoin traversed by mi'.^ratin^ blctod eorjmscles as freely as a cnlluid is |ienetrated by a crystalloid. ■19 — -1 . — B T = = 3 E U: It Z. c r- 2, c B p. ."I 1 c o re j5 o s- < 3* t-^< t ■r ? 5' T re 5 B p o' c - _ > (B . — r- 2 to !" i' I I re ? — re r. c = ~" re* p' 2. w '\l .S^ ■L^ < '? - ^P^i:^ iP' -rp >^' Cicatrization. — Let us now inquire briefly how cicatrization proceeds, and note that it is in the cells that the most important changes are to be recognized. Those nearest the injured part gradually assume a spindle shape, and the intercellular tissue into which tlu'se spindle-shaped cells are infiltrated becomes denser. The spindle-shaped cells then gradually change into ordinary connective-tissue corpuscles, and in this way new cicatrical tissue is formed. This new tissue, however, again undergoes change.* — changes of consolidation. The intercellular tissue becomes gradually more condensed, and the spindle-.shaped cells assume the flat shape of connective-tissue corpuscles and in a measure disappear, the nucleus alone often remaining. The fluid that existed in the newly-formed tissue is absorbed, and the new cicatrix by degrees becomes firmer and denser, gradually contracting ; so that at last the delicate scar of a large wound becomes solid and compact. The cicatrix in smaller wounds appears only as a thin red, and at a later period as a white, line. Changes in the capillaries of tlie ])art are, however, going on during all this period, hut how far all the changes that have been briefly described are due directly to the capil- 28 PROCESS OF REPAIR IN WOUNDS. lary action is not yet determined. If Cohnheim's views be adopted, it is to the capil- laries that the chief action in the tissues must be ascribed ; but if those of other patholo- gists, such as Yirchow and Billroth, be accepted, the capillary action takes a secondary place and the cell elements take the leading one. On either theory the importance of the capillaries cannot be overlooked With regard to the changes in the capillaries, it has been already pointed out that at the beginning of the reparative process the capillaries of the part become sealed and the collateral circulation in the neighborhood becomes irregular and pressed upon, and that the coagula in these obliterated capillaries become reabsorbed, or possibly reorganized, as repair progresses, since it is certain that the capillary network soon becomes continuous through the newly-formed cicatricial tissue, and that the capillary meshes of the one side join, by loops projected through the new tissue, similar meshes of the opposite one. What injiuence the nerves of the ]m)t have upon the reparative process we do not know. That they have an important influence there can be little doubt, since all physi- ologists recognize their power upon secretion and nutrition ; the vaso-motor nerves doubt- less have the greater power. But we must learn something more of nerve power gen- erally and nerve distribution — something of the way in which the nerves terminate in the tissues, and what relation they bear to the capillaries — before we can hope to find out or understand the exact influence nerve supply has on repair. Repair by Granulation. — All wounds do not, however, heal by immediate union or by primary adhesion — /. ^., first intention ; and wounds that gape cannot so unite. The process of repair in them differs, therefore, somewhat in its character from the process in those which we have been considering: it takes phi ce hy (jramdation^ or the "second intention of Hunter." If we closely examine the surface of a wound thus exposed, we shall find that it becomes, within a few hours of its exposure, covered with a film of a peculiar gelatinous, grayish-white appearance, which will be seen, with the aid of the microscope, to be composed of granulation cells or white blood cells, " Hunter's plastic lymph." After an interval of some hours the parts covered with this gelatinous grayish film become more vascular, as indicated by redness, and the surface more even. The film itself assumes a tougher character, and a yellow fluid, which is mixed with small yellow sloughs of fibrinous tissue, is secreted. The wound begins " to clean," and to have a smooth and consistent surface. After the lapse of another day, or some days, perhaps, this .surface is covered with a number of elevations, known by the name of grmndations, varying in size from a millet-seed to a hemp-seed, the smaller being highly vascular and red, the larger being, as a rule, paler and more bloodless. The wound at this time is "granulating." and the secretion from it is now of a creamy-yellow character, and is called pus. The granulations are made up of cells called granulation cells, which resem- ble inflammatory lymph cells, and each granulation contains a vessel the walls of which consist of a thin membrane in which nuclei are embedded. " Some of these nuclei are arranged longitudinally, others transversely, to the axis of the vessels. In the develop- ment of these vessels changes occur answering to those seen in ordinary embryonic development. Organization makes some progress before ever blood comes to the very substance of the growing part, for the form of cells may be assumed before the granu- lations become vascular. But for their continuous active growth and development fresh material from blood, and that brought close to them, is essential. For this the blood vessels are formed, and their size and number appear always proportionate to the volume and rapidity of life of the granulations. No instance would show the relation of blood to an actively growing or developing part better than it is shown in one of the vascular loops of a granulation embedded among the crowd of living cells and maintaining their continual mutations. Nor is it in any case plainer than in that of granulations that the supply of food in a part is proportionate to the activity of its changes, and not to its mere ".structural development. The va.scular loops lie embedded among the simplest pri- mary cells, or, when granulations degenerate, among structures of yet lower organization ; and as the .structures are developed and connective tissue formed, so the blood vessels become less numerous, till the whole of the new material a.ssumes the paleness and low vascularity of a common scar " (Paget). Forrnation of New Skin. — If, at this time, when the granulations have attained to the level of the skin, we look to the margins of the wound, we shall see a dry red band of newly-formed tissue, with an outer border of a blui.sh-white color where it comes into contact with sound integument. This band is the new skin forming, and is caused by the gradual growth of the epidermis from the margin of the sound skin toward the centre of the sore. Such a process is called ''cicatrization.'' The cicatrix is at first red, rnocKss OF iiki'MR is worsns. 29 as ill the linear t-icutrix, t(» wliicli \vc li!iv(! ain-aily aliudcMj, }»iit as it cdntracts it hnh.-^e- (jui'iitly licrniiR'S j)ak'r, iimiH' r(tiiij)a(.-t, and aillicri'nt. Tlic iiatnn; of tin; s(;ar kt cicatrix varies witli tlic tissue in wliicli it is turincfl, the \ww coniicctin*; UKMliiirn under all cir- cunistanci's havinj; a powerful tendency to approach (he peculiar charact«-r of the tissue in which it is placed. 'I'hus, a cicatrix in the skin in time closely reseinhles true skin; a cicatrix in hone, trui' l)one ; and a cicatrix in tendon heconies tou^h and hard like tendon. I'lider all circumstances the con.s(didatin;j; reparative material partakes of the charailir nl' the parts wliich it connects. Secondary Adhesion. — When two granulating; surl'aces are brought together and union takes place lictwec!i them, /lealiin/ hi/ •' xtcoin/tin/ ml/icsio/i," or hy t/ic •■ lliinl intent inn." is said to occur. The process of rej>air, under these circumstances, is similar to that of imnu'diate uv adhesive union, the two layers of granulations adhering, either directly or hy means of some new material, as two surfaces of divided tissue. 'I'he cafiil- laries and cmliryo cells, under both circumstances, undergo changes such as have been described. For this form of union to take ])lace, the granulations, however, must be liealthy. Scabbing. — ^\'lleM wounds Ileal •' 1)1/ seiil/ljiiit/," granulations do not form. In this proces.s the reparative material which is poured out undergoe.s at once similar changes to tho.se already described as taking place in adhesive union, and the wound cicatrizes rap- idly beneath the scab ; for the .serum of the blood, when cffu.sed on the surface of a wound, is of a highly plastic character, and quickly coagulates to form a film of a j»ro- tective nature, under which repair may rapidly proceed, the embryo cells, with this — Hunter's '' plastic lymph"' — being the medium of repair. The treatment of sujierficial wounds is based upon the knowledge of this process, and the value of felt, cotton-wool, or any similar material, when applied to an open wound, entirely depends upon this plastic property of serum. Repair by scabbing is doubtless the best form of healing, although it is, uiii'nrtuiiatcly. somewhat rarely obtained. The Nature of the Heahng Process is physiological, and resembles closely that of development and growth. The changes in the cell-elements which have been described in repair, and the gradual development of the most elementary tissue into cicatricial tissue or higher structures of the human body, are similar in nature, if not in form, to those which are witnessed in the embryo when the blastoderm cells, or primary nucleated mass of protoplasm, in the ovum, grow, develop, and differentiate into the various struc- tures of the human animal. For the healing processes there must be a sufficient blood supply for nourishment, and there mu.st likewise be a regulating force to control and direct the formative process ; and this lorce doubtless comes from the nerves. When the vascular supply is deficient, growth or development must suffer and the physiological process of repair cannot go on; when the vascular supply is in excess, what would have been a physiological becomes a pathological process, and the part undergoing repair after injury is said to be "inflamed." The process of construction, under these circumstances, ceases, and that of (lesfmction may ensue ; or there may be changes in the now inflamed but formerly repairing wound or granulating surface, which will be considered under the heading of '• Diseases of Granulations.' What I would now impress upon the reader is that whatever action is required for the healing proce.«s is physiological, and is just equal to its purpose ; when it is excessive, it becomes patho- logical, and is known as "inflammation." Inflammation, when it attacks a wound, at first checks repair, and later on brings about disorganizing changes ; inflammation, under all cireumstanees. has a destructive tendency. Regeneration of Tissues. — It has already been pointed out that the proce.«.«e.s of repair are identical in all tissues, that the re])arative process in bone or muscle, integu- ment or tendon, capillary or nerve, is the same, such modifications alone showing them- selves as necessarily appertain to the histology of the tissues ; and it is well that this physiological truth should be fully recognized. At the .same time, it is to be eart is a rctanlcr of n-pair or a cause of" iioii-rf|iair. Wlicii a wound lias to lical l>y granulation, a dot ol" hlood. as a (.'overin^. kept aseptic, is ItcncHcial. .sincr it ai'ts as a protector to tiie surface of the wouiul and allows the ^ranulatinu; process to f^o on uninterruptedly. It has heen saiti that such clots hecoiiie oriranized, hut it is far more prohahle that llicy simply act, as ahove descriheil. as a prn of parts, the surp;eon knows that immediate or primary union of the wotmd is not t(» he expected. I'nder these circumstances a lim? of treatment will he indicated which will he far more likely to he efficient than one l)ased on the hope of ohtaining <|uick repair. When the contusion or hu'cration is sliiiht, tin; hope of securing; ju-imary unioti of the divided parts may, indeed, he entertained ; hut when it is threat, such a hope would he alto^^ether s. In j;unshot wounds special forceps and otlier instruments may he rerpiired. Those who helieve atmospheric trerms to he the (diief cause of inflammation and sup- puration, or of most, if n(»t all. tlm ills to wliieh wounded flesh is heir, will employ the means that are supjtosed to he capable of de- strovinj; such maliuiiant foreign visitors, and for this purpose will use the spray of carbolic acid, one part in forty, or other antiseptic, to kill the irernis in the air as they approach tlie wound, and will dress the wound with the carbolic lotion, carbolic irauze, protective, and waterproofiuLT. according to directions lairl down in a future page (vi(h^ Listerian method of dressino; wounds) ; whereas those who disregard atmospheric germs, and yet highly value means for purifying wound surfaces, will use antiseptic irrigation of the wound with a lotion of carbolic acid 1 to 20, of thymol 1 to 100(1. of chloride of zinc 20 grains to tlie ounce (originally used by Mr. C de Morgan many years ago), or of iodine, made by adding 10 drops of the liquor iodi to the ounce of water. I have employed the iodine lotion for years, and prefer it to any other. It is always at hand, and is both simple and effectual as a wound cleanser. The lotion may be used warm, and it has the advantage of not only cleansing the wound in the fullest sense of the term — for iodine is an antiseptic — but it has a marked tendency to arrest all capillary bleeding or oozing. I use it in about the proportions given above, but the best practical guide is to pour the solution or tincture into a basinful of water, so as to make tlu' lattt'r of a light sherry color. Arrest of Bleeding. — It is well that haemorrhage should be effectually arrested by some of the various means which the surgeon has at his command before the edges of a wound are brought together, and it is wise to have even capillary bleeding stopped, when it is possible : for blood effused in even limited (juantities between the surfaces of an incised wmmd is to be regarded much in the light of a foreign body, and as forming an obstacle to repair, more particularly when primary union of the wound is to be sought for. Indeed, it was on this account that I was first led to employ. f(jr cleansing wounds, the iodine water to which I have drawn attention, and which I cannot too strongly recom- mend for general adoption. A sponge wrung out of this lotion (made with hot water), and held to a wound for a minute, completely checks all oozing of blood, and tends more than anything else, except prolonged exposure to the atmosphere, to the formation of that glaze upon the surface of the wound which so much conduces to satisfactorv repair. Irrigatiiig-Bottle and Apjjaratus. On the Question of Repair by Primary or Secondary Adhesion. When the surgeon has cleansed the wound, removed what foreign bodies may have been present, and stopped all bleeding, he has to decide upon the means whereby the reparative process may be best heljied, and as a primary point to determine either the feasibility or expediency of attempting to obtain quick or primary ituion of the cut parts, or the wisdom of looking to their repair by the slower npen^ (jruinihiting process. When the wound is f)f the indued kind, the question is not difficult to answer : for it may with confidence be asserted that, with few exceptions, in all wounds of this descrip- tion, whether superficial or deep, accidental or the result of operation, repair by quick or .3 34 TREATMENT TO HELP QUICK OB PRIMARY UNION. primary union is to be desired, and, what is more, may be expected if the subject of the wound be healthy and not too old, and if nature's reparative process be so aided by sur- gical art as to be allowed to take its course without interference. The cleaner the cut is, the greater is the probability of its uniting by quick repair ; the more ragged, contused, and lacerated the margins of the wound are, the less are the prospects of obtaining primary union and the less the wisdom of making the attempt. Between these two extremes are innumerable gradations. Where there is a doubt about the wisdom of making the attempt to secure primary union in deep, contused, and lacer- ated wounds, let the decision' be against it ; and when the doubt applies to the more superficial or hopeful class of wounds, let it be decided in its favor. Care must, however, be taken in these as in all cases to give up the attempt on the appearance of the slightest local or constitutional symptoms. It is also necessary to bear in mind that by drawing together the parts by sutures, etc., some retained blood, serum, or sloughing tissue may keep them in a state of unrest^ either by tending to separate the lips of the wound and exciting tension, or by undergoing chemical changes and decomposition and thus favoring the production of some septictemic or pygemic conditions. For it must be recognized that whilst in the cleanest incised wound there maij be no death of the divided tissues, and consequently no animal matter to undergo chemical changes or putrefactive decomposi- tion, in the contused and lacerated there mud (jf necessity be more or less. When tissue dies, it must be shed or cast off fro)n the living parts before the physio- logical reparative or uniting process can take its course. AYhen this dead tissue has been separated from the living, it ceases at once to be influenced by the vital processes by which it had been built up, kept clean, and eventually cast off; it consequently becomes subject to the physical laws of all dead matter, and undergoes chemical changes — which means too often decomposition. The object of the surgeon, therefore, in the treatment of these cases of wound in which the death of tissue is to be expected, and cannot be prevented, is to neutralize as far as possible the evil influence of its death and probable decomposition. This is to be achieved by so dealing with the injured part that the dead tissue may find a free outlet for its dis- charge, and by rejecting all such applications or dressings as are likely to help putrefac- tive decomposition, at the same time employing means and agents likely to neutralize its pernicious influence and to control, in a measure, the process of decay. Treatment to Help Quick or Primary Union. To promote the primary union of a wound, the surgeon has six cardinal indications to follow : 1 . To cleanse the wound. 2. To arrest all bleeding. 3. To effect coaptation'of the two divided surfaces of the wound, the deep parts as well as the edges. 4. To maintain the wounded parts in a position of immobility beneficial to the natural process of repair as well as comfortable to the patient. 5. To secure drainage of the wound by providing for the escape of such dead tissue as may be thrown off, as well as of all fluids that are not required for repair. 6. To protect the external wound from all such outside influences as may be preju- dicial. The first two indications have been already considered — viz., the cleansing of the wound and the arrest of bleeding (pp. 32, 33). In all forms of wound, and for every form, of healing, attention to these points is most important ; but when quick or primary union is to be expected, it is all-essential. Third Indication : The Coaptation of the Edges and Surfaces of a Wound. The coaptation of the two divided surfaces of the wound may be efficiently carried out in superficial or not deep wounds by means of sutures and adhesive plaster, sepa- rately or combined. When, by the use of trustworthy adhesive plaster, the object sought for can be obtained, sutures are not called for ; and when sutures are used, the form of suture that carries out tlu> object in view in the simplest way is the best. Interrupted Suture. — When the wound is supeyJrciaL the sutures need not be introduced deeply ; but when the wound is deeji, the practice of bringing the edges of ruiiu) isDicATioy. .35 V\r.. 1. flo it. How tiot to do a The Interrupted Suture. till' wiiiirnl, ami not the il('i"|icr |iaits, lu^tllicr is IVaiiulit with arts til' till' wiMiml hldnd, siTHiii, ;h one side of the wound ohliipu'ly from without inward, and made to ])ass through the opjiosite side in the rever.se direction i'miu within outward. The knot of the suture slioiild he hnuiuht to one side of the wound, as shown in lig. 4. In the xnpcijicidl it should be inserted with sufficient depth and closeness to bring the .surfaces and edges of tlie ])art accurately and closely together, and it should be tied with enough Ibrce to carry out these objects, but not with more, since to tie a suture as a surgeon would a ligature is to do harm, as the suture would cut rapidly through the strangulated tissues, and in so doing irritate the ])art instead of helping repair. In tlcrp wounds the suturse must be inserted deeply, as in hare-lip operations, and introduced well away from the edges of the separated tissues, so that when they are tightened the deeper parts as well as the superficial will be brought effectually into appo- sition. In some cases deep and superficial sutures may l^e made to alternate. Superficial sutures should include neither muscles nor deep fascia. A double-reef knot is usually employed, but a "granny" (Fig. 137) is by no means a bad one to make, since it is a slip-knot and can be tightened at pleasure by a third tie. In the majority of cases in which sutures are employed it is an excellent plan to alternate the sutures with strapping; a narrow band of the latter carefully adjusted between the stitches not only materially aids the adaptation of the edges of the wound, but, if well applied, tends to prevent ten,sion and to immobilize the wounded structure, while at the same time it acts in the way of affording local pressure to the deeper parts of the wound. In operations on the breast the advantages of this practice are well exemplified. Continued Suture, — The uninterrupted, continued, or Glover's suture (Fig. 5), the stitch of the sem|»«;tress, is valuable in all cases in which a very close aiid accurate adaptation of the margins of the wound is wanted, as in wound of the intestine, as well as in those of the eyelids and face generally ; indeed, a clean wound of these parts, superficial or deep, may be so accurately and well adjusted by means of a fine needle and thread as to leave but a minimum of scar. In opera- tions about the lip the same remark is applicable, although in these care .should be observed to intro- duce the sutures deeply and well away from the mar- gins of the wound. In operations for phymosis in the adult this form of suture is likewise of great value, as it not only expedites recovery, but does much to make the result of the operation more artistic. In these cases the fine carbolized gut suture may be used. The stitches should be removed on the third or fourth day. They may often be taken out of the face on the second. If left in long, they are ajit to set up irritation and ulceration. Twisted Suture. — The twisted suture (Fig. G) is of value in certain operations on the lijis and cheeks, and in other parts where difficulty is experienced in bringing the parts together, since by its use more force can be brought to bear upon the margins of the wound, and their adaptation can thus be rendered more perfect. This form of suture was in former times the one commonly employed in hare-lip operations, but it is not so now. I have for years discarded it in favor of the interrupted suture of silkworm gut, or wire, and employ it only in cases in which exceptional difficulty is experienced ia Fig. The Continued Suture as .Applied to the Intestine. 36 THIRD INDICATION. bringing the parts togotlior. It is iisoful. liowever, in (•liciluplastic operations, as ■well as in the Pirogoff anil Cliopart's an)putations. To apply it, some fine pins with flat heads, silk, anil cutting pliers are wanted. The pins are em- FiG. 6. ployed to bring the surfaces of the wound in contact, and their points should be introduced half an inch or ninre from the margin of the wound, and passed deeply and obliquely, in lip operations, through the thickness of the ti.ssues down to, but not through, the lining mucous membrane (Fig. G). They should then be made to pass through the opposite side and brought out through the skin at a corresponding point. A piece of silk passed as a figure-of-8 should be twisted around the two ends. The wound may next be drawn together; and should the apposition of the surfaces be imperfect, the pins should The Twisted .Suture. be taken out and the parts be readjusted, and in this lies ■ the great advantage of this form of suture. After the silk has been tied in knots and the ends cut off', the points of the pins should be removed and the soft parts protected from the ends, if necessary, b}' the introduction beneath them of a small piece of lint or strapping. Instead of silk being twisted round the pins, a sec- tion of an india-rubber tube in the form of a ring has been employed by 3Ir. Kigal, and the late W. L. Atlee of Philadelphia. The ring is slipped over the ends of the pin, and serves by its elasticity to keep the parts together. Quilled Suture. — This form of suture (Fig. 7) is applicable where deep wounds have to be Vtcil held together along their whole line, and more particularly for a brief period, .say two or three days. In Fig. 7. ruptured perineum it used to be in general use combined with super- ficial sutures, but the interrupted sutures of silkworm gut, introduced well away from the margins of the wound and inserted deeph, are ]>robably to lie preferred. For the application of this su- ture, a strong curved needle with an eye at the end and threaded is to be inserted at least three-quar- ters of an inch from one margin of the wound and made to pass well down to its depths, then brought out through the other margin in a corresponding line. The loop of the suture should now be caught and held and the needle withdrawn ; a ])iece of bougie, cut the required length, being intro- duced into the loop, is fixed by drawing the free ends of the ligature home (Fig. 7 a). A second or third suture can be applied in the same way. A second piece of bougie ought then to be tied on the opposite margin of the wound, the parts having been well cleansed previously and carefully adjusted. The surfaces of the wound are only to be held closely in apposition, and must not be pressed too firmly ; otherwise, the bougies will set up ulceration. Superficial sutures may subsequently be intro- duced into the edges of the wound (Fig. 7 B). For the quill suture good fishing-gut is better than silk or wire, as it is strong and unirritating. Before u.se it should be soaked in water, to make it limp ; it can be readily tied or fastened with a .shot. The loops of the (juill suture .should generally be divided on the fifth or sixth day, but this depends on the amount of irritation caused by the bougie. The Button Suture, as a variety of the quill, is useful in some amputations, as the thigh, where the surgeon is desirous of keeping the bases of the flaps together, and in breast cases and in hare-lip or other lip operations (Fig. S"). Material for Sutures. — With respect to the material used for sutures, silk, wire, silkworm gut, prepared catgut, or horsehair are each good in certain cases when rightly selected. "When there is little tension on the sutures, The Quilled Suture. Fig. 8. Button 8uturt For inn isinrAnny. 37 silk or wire may be iniliffi-rently employe*!, the umi»unt of irritutiori exerted by one or the otiier materiul ile|ieii«liii^ more upon tension than on any other condition. I have hiii^ proved this to n>y own .satist'uction by testing both form.s of suture in the same subject through a h»nj^ series of cases. ill jilnstic operations silkworm ;rut well .softened in water before use is to be recom- meiideil ; it holds well, and seems to irritate far U'ss than any other material. In ca.ses of ruptured perineum and in operations for va<:iiial tistula and fissured |ialate it should always be used. In the latter class of cases, where the .soft palate alone is involved, horsehair is good, but it is not strong enough to resist much teiisi(»n. In plastic operations, in which some skill may be called for in adjusting the parts, wire sutures may be seb'cted, since they can be twisted and untwist«'d with facility, and the sur- geon can coiisc(|ueiitly readjust the margiii> of the wound as reris.siire is the most important, as ably advocated by (iamgee. Indeed, the value of pressure in the treatment of all wounds is worthy of more consideration than it has received. By it the surfaces of divided parts are kept together, and particularly the deeper surfaces : mobility of the injured tissues is checked, if not prevented; the vessels of the wounded parts are sup- ported; and the evil influence of blood-stasis, with its effect, effusion, is neutralized. Under the.se circumstances repair is helped, and nature's proces.ses are permitted to go on under more favorable conditions. With this view of the value of pressure, well applied pads of lint, absorbent cotton-wool, gauze, or sponge, saturated or not with .some anti- septic drug, should be carefully adjusted over the flaps of all wounds when such exist, and over tlie surfaces of others. The.se pads are kept in position by means of strapping or bandages, aided by splints when the extremities are involved. After the removal of a breast or tumor, the value of a well-adjusted pad, and more particularly of sponge wrung out of iodine or carbolic water, cannot be too highly praised. After an amputa- tion, the use of a splint adjusted to the stump, and pressure well applied to the bases of the flaps, not to the edges, should never be omitted. Fourth Indication. The Maintenance of Wounded Parts in such a Position of Tmmn- biUty as may be Favorable to the Natural Process of Repair and Comfortable to the Patient is the fourth indication ill the treatment of incised wounds : and. to say the least, this is as important as the preceding indication, since, if neglected, the benefit that might be expected from efficiently coaptating the wound could not be realized, and the process of repair in the wounded part would of necessity be checked, if not altogether prevented. To carry out this indication. immoliiUtt/ of the wounded part is of the first importance, and its position next. The position is always selected with the object of giving ease to the patient and of preventing pain : of relaxing the wounded tissues, and so guarding against any tendency to bring about a separation of the edges of the wound, as in cut- throat cases; and last, but not least, of encouraging the return of the venous blood from , e wounded parts toward the heart. Thus, in wounds of the trunk the horizontal posi- tic is the right one to be maintained, and in those of the extremities flexion and eleva- tion of the limb ; in wounds of the lower extremity the foot should be kept higher than the knee, and the knee than the hip ; and in those of the upper extremity the .same prin- ciples of practice should be fidlowed. the elbow being generally flexed. Under all cir- cumstances wounded limbs should be fixed upon splints, with the view of immobilizing them, and, as a rule, they should be swung. This practice adds greatly to the comfort of the patients by allowing them to move their trunks without their wounded extremities, and without, therefore, interfering with repair. It should be added, however, that the question of position ought always to be considered in reference to x\iQ fifth indication — - 38 FIFTH IXDJCATTOX. namely, the necessity of providing efficient means for the removal of the superfluous fluids of the part, and for the escape of disintegrated dead tissue which may have to h-i discharged, or, in other words, for draliiage. Fifth Indication: Drainage. Drainage, or the making of due provision for the escape from the wound of disin- tegrated dead tissue, with such fluids as are not required for repair, and which, if left, might prove injurious, is of primary importance in the treatment of all, and more par- ticularly of deep, wounds. It should never escape the attention of the surgeon. In scalp wounds and those about the eyelids, though they may appear trivial, it is of as much importance as it is in the wounds that involve deeper parts and seem more severe ; for in the one case, as in the other, pent-up fluids not only separate tissues which are intended to unite, give rise to pain b}' producing tension, and consequently cause consti- tutional irritation, but they are prone to excite inflammation in the part, and ultimately to undergo septic changes, which in their turn may give rise to blood-poisoning in the form of septicfemia or pyaemia. No other than trivial wounds, consequently, should be completely covered in. and deep ones very rarely. Some corner, and preferably that which is the most dependent — some interval between the sutures or strips of the pla.ster — should always be left open for the escape of disintegrated tissues and of superfluous fluids, such as blood or serum, and where deeper structures are involved some conducting material, or '' drainage-tube," should be introduced. The best is a tube of india-rubber perforated at intervals (as originally suggested by Chassaignac. 1855). of a. size varying with the cavity or wound to be drained ; but in some cases a strand of carbolized catgut or horsehair, a roll of gutta- percha skin, or a piece of lint saturated with carbolic or terebene oil will do as well. In abdominal cases, as after ovariotomy, a perforated glass tube is of great value, while under other circum.stances an elastic catheter will answer the purpose. The particular mode of accomplishing the object is of little importance, so long as the object itself is secured. Caution in Use of Drainage -Tube. — In using a drainage-tube, however, the surgeon nfust remember that it is not to be made a seton. and that the sole justification for its use is to drain the fluids from the deep tissues. For this purpose the tube is to be made to dip deeply enough into the wound, but no more : it is not to be made a cause of irritation. The size of the tube is to be regulated by the requirements of the case ; several short tubes are often better than a long one. Care is also to be taken that the outer ends of the tubes are left free ; when covered, they .should be covered but lightly, and then with some absorbent cotton, oakum, sponge, or gauze. As a rule, however, they should be left open. Position of Tube. — In using the tube, when the end is cut off" level with the wound, the outer extremity should be held by means of loops of carbolized silk, perfo- rating its walls and secured externally by strapping or other means. The tubes should always be introduced at what will be the most dependent part of the wound when the patient is in the recumbent position, and they should be taken away as soon as they have answered their purpose. When quick or primary union has taken place, they may safely be removed at the end of twenty-four or forty-eight hours ; but when suppuration is present, they must be left longer — sometimes even till the cavity has nearly closed. A drainage-tube should, however, be shortened as rapidly as the progress of the ca.se will allow, the shortening of the tube and the clo.sing of the cavity of the wound from below going on together. It is to be noted that at the present day the use of drainage, whether by tubes or other material, is suggested with the view of jrrevcntwg suppuration in the treatment of deep wounds ; whereas in former times, when Chassaignac introduced his tubes, it was for the treatment of wounds and cavities in which suppuration already existed. The value of the principle is. however, equally great in both classes of cases. When carbolic acid is used as a wound-dres.sing. whether as a .sprav or as a lotion, or when chloride-of-zinc lotion is employed, the use of the drainage-tube is more necessary than it is when other forms of dres.sing are employed, since under the stimulating influences of the.se drugs there is. as Lister tells us. more eff"usion of plasma than is to be looked for in other circumstances. Caution in the Closure of Wounds. — Whenever a wound is dosed, with the view either of obtaining rapid or primary union or of converting an open as far as possi- o.\ Tin: sh-cn.M) ni:i:ssrya of a cr.oshn wnrxn. 39 ble intii a siilx-iitaiuMdis wuhihI, the iiutst careful iri.speetioii is called for, tr) fruard apainKt, and even to anticipate, truiiMe. In these cases the wound siioiild he opened <»n the sli;rht- est approach ol" local tension or overaction with elevation of temperature and traumatic fever, since su(di local and constitutional disturhance will jiroltalily he i'oiind t«» he due to tin- retention of some of the fluids of tlu; pari that are in excess of what i.s wanted ibr rejiair, and can he relieved only hy the evacuation of su(di retained suhstanccs. Sixth Indication: The Protection of the Wounds, etc. The protection «d' the external wound from all such otitside influences as may be prejudicial to the proL'ress of natural repair is the sixth and last indication for the sur- f^eon to follow ; and it is in itself as important as the five which have preceded it, since it includes the use of all means hy wliich the wound can he protected from outside injury, as well as the dressing proper or covering: of the wound. For purposes of protection, most wounds re(|uire a coverin AM) L.\('i:n.iTi:i> wounds. 41 tliul tlit'V wtTi' s(i ;i|i|ilii'il at tirsi In allow I lie siir;^t'i)ii tn rciiiosc. wlicii riocessary, tiit; oxtiTiial (Invssiiii^ witliuiit iiitcrrcriiiij: with tliciii. With tlic saim- vii-w, of pn-veritiii^ tlic not'i'ssitv <»i its t-arly rt'iiioval, a splint sliuiild Itr covfrccl with siititt if repair is to f;o on steadily, and this (piiet is as necessary for till' lacerated as it is for the cleaner kinds of wound. A form of dressinj^ such as ha.s been doscril»od has advantages over many others, for it renders early and frerjuent dress- ings of the wound unnecessary. Punctured Wounds. Punctured wounds, when made with .sharp-cutting instruments, are deep inclsrtl wounds, and when with blunt or wedge-shaped tools deep ctiiitinit.il wounds. They differ from other incised and contused wounds in their depth and in tlie uncertainty which, a.* a consequence, follows with respect to the tissues that are wounded, but, above all, in the difficulties whicli are always experienced in providing for the efficient evacuation of blood, serum, or broken-down tissue, where drainage is needed. These difficulties are clearly due to the external orifice of the wound Iteing but small in proportion to tlie depth of the penetration. When a punctured wound is made with a clian^ shitrp instrvment into the healthy tissues of a healthy suVjject, harm may not be anticipated ; indeed, quick repair may be looked for with almost as much confidence as if the wound had been of the more simple incised kind. This observation is coiifirmod by the general experience of all who practise subcutaneous surgery, although wlien large vessels or nerves are wounded troubles may arise which are not lessened by being hidden. When, however, a punctured wound is made by a hhinf anti tcedge-Hliapeil , or possibly a ilirti/, instrument, the wound will be of the contused kind, and, being so, it will partake of the disadvantages of such wounds in addition to those which appertain to it as a punc- tured wound. It will conse(juently, being contused, be associated with death of some of the injured tissues, for the escape of which due provi.sion will be required, and it can only he expected to heal b}' the second or third intention. Being a punctured wound, it will, moreover, exhibit the difficulties of providing for proper drainage under circum- stances in which efficient drainage is particularly called for. As a con.secjuence of these conditions, special dangers are developed W'hich can only be rightly met by a full recog- nition of their nature and of the requirements essential to their prevention. When tense fascijv; are punctured — such as are found in the palm of the hand, sole of the foot, and scalp — or when deep muscles bound down by fa.sciae, as in the thigh, are involved and secondary inflammation ensues, the case is often very serious. Punctured wounds of cavities are wor.se than those of the soft parts covering bones, in the .same way that all other wounds of cavities are graver, as well as from the fact that in punc- tured wounds there is more uncertainty as to the nature of the parts wounded, and that with this uncertainty there are. of course, loss clear indications for treatment. Treatment of Punctured Wounds. — There is no form of wound which the surgeon has to treat in which a greater uncertainty exists as to the results of treatment than in the punctured, and all punctured wounds should be dealt with, therefore, with the greatest caution. When the wound has been accidentally inflicted with a clean, sharp instrument, and when it is treated, as it should be, like any other clean wound, with moderate compression and the application of a dry or antiseptic dres.«ing. such as terebene and oil, and is then left yirotected and at rest to heal, there will be every pros- pect of repair going on as satisfactorily as in wounds which surgeons daily inflict in their 44 TREATMENT OF OPEN WOUNDS. operations of tenotomy and osteotomy. Even when the wound is of the contused kind and repair by '• quick union " is not to be looked fur, tlie surgeon is probably justified in employing the same means, although in doing so lie must be keenly alive to the risks of the case and the dangers of the practice adopted. He must be ready, on the appearance of any swelling, pain, heat, or redness, and more particularly of any elevation of temper- ature, to remove all dressings, expose the wound, and adopt means to give vent to the pent-up fluids of the part and relieve the local irritation caused by their retention ; by so doing he will jtut an end to tension of the tissues, and probably check the further absorption of substances which, if not already decomposing and undergoing chemical changes, may soon do so and give rise to septicjvmia and blood-poisoning. In one case this may be done by reopening the external orifice of the wound ; in another, by enlarging it ; whilst in a third, a fre.sh r)pening may be called for in the most dependent point of the injured region. Under all circumstances, however, the object is the same — to give vent to pent-up fluids, whether inflammatory or otherwise. At the same time, the injured part should be raised, to encourage the venous circulation through the limb, and pain should be relieved by the local application of warmth and moi.sture, whether in the form of a compress or in that of a fomentation mixed with sedatives, such as opium or poppy decoctions. Cold rarely gives comfort in these cases, and it certainly does no good toward checking inflammatory action, which, if occasioned by retained .secretion, is only to be relieved by its removal. For the same reason leeches are rarely applicable, although in a plethoric and vigorous patient they may be permissible ; but even in such the judicious use of small and repeated doses of sulphate of magnesia has a more powerful efl^ect for good, with less risk of doing harm. In the treatment of all punctured wounds it must be remembered that, as the chief danger lies in the dilficulty of providing efiicient drainage, the result turns upon the completeness with which this necessity is met. The surgeon who, on the first appearance of local or general symptoms indicative of the presence of retained serum or other fluids, makes an outlet by one of the means which have been suggested, will be more successful than one who, from timidity or other cause, leaves the case to run its course till a large inflammatory abscess has formed. In all punctured wounds which do not heal c|uickly by primary union, and in which secondary inflammation occurs, with its necessary effusion, an outlet should be made for the fluids of the part as soon as the fact of their retention is clear. When thecae of tendons, fascia?, and fibrous coverings, as of bones, are in- volved, the necessity of providing for this outlet is more important, if possible, than when the softer tissues are implicated, and an incision into the deep parts for the evacu- ation of simple serum, by relieving tension, will often prevent both the extension of the inflammation and the destruction of tissue. Tooth Wounds. Tooth wounds are usually punctured, and rarely other than contused. They may, as may all other kinds, prove to be poisoned wounds, but to them I do not refer. They differ widely in their character, and, whilst one case may appear as a simple clean punc- tured wound, another may exhibit all the worst features of the contused or lacerated variety. They are to be dealt with as punctured or contused wounds, each ca.se being treated on its own merits. Treatment of an Open or Granulating Wound. When a wound is granulating, and consequently suppurating, it should be kept clean, as should all wounds, and it .^^hould be dressed with such a material as may be.st protect the granulations from outside injurious influences and allow the cicatrizing process to go on without hindrance. The granulations themselves should never for purpo.ses of clean- liness be touched by any coarse material harder than a camel-hair pencil, but should be washed by means of a stream of some antiseptic fluid allowed to flow from either the irrigating-bottle or dressing-can (Fig. 8). In my own practice iodine water is generally used. When the granulating process is not of a healthy type, but shows either deficiency or excess of power or some morbid action, medicated lotions and constitutional treatment may be required, to which attention will be directed farther on. Srr.riM, rilEATMKNT Ol' Wol'SDS. 45 Treatment of Wounds to Promote Healing by Secondary Adhesion. As ill tlio tri'utiin'iit u[' a IVcsli wouikI tn nlitaiii a ''(jiiick or |»riiiiarv adlicsioii" the sur;riM)ii lias siiiiitly to cleans^ tlic wound after arrest iiiloyed in continental towns, by the use of bandages, charpie, lint, etc. The system of dressing wounds by what has been described as the " smotherinir method,' in which no air could get in or fluid get out, gave way to the ■' open method,"' in which the free access of air was the main end sought for, and drainage the second. The success which attended this practice was, moreover, considerable, since Bartscher and Vezin had only- three deaths out of thirty amputations, and Burow three out of ninety-four. The method, nevertheless, did not make headway, and it does not seem to have been followed as a rule of practice by any surgeon except Messrs. Teale of Leeds, Professor Humj)hry of Cambridge. Dr. R. W. KriJnlein of Zurich, and some members of the Surgical Society of Mrtscow. Teale and Humphry in 1850 and 18G0 (Brit. Med. Joh?-h. ), Krbnlein in 1872, and the Mcscow Surgical Society in 1877, have given their respective experiences and recommen- dations in regfard to this method of dressing. Von Kern's practice consisted in freely exposing the wounded surfaces to the air and simply keeping the edges of the wound in position by means of sponges. Vezin applied no kind of means for uniting wounds. Burow used sutures, but in such a way that they could be readily loosened in case of distension. Professor Huinphr}' wrote : ' '"It is well known that wounds of the face commonly heal up in their whole length by first intention. This is due, in great measure, to the vital qualities of the parts, and in some degree also, I apprehend, to the fact that they are usually left exposed to the air. their edges being held in contact merely by sutures. For some years we have adopted this plan after amputations and all, or nearly all, other operations. The integuments are united by sutures placed at intervals of about an inch, and the wound, as well as the adjacent surface, is left quite exposed to the air, no plaster, bandage, or dressing of any- kind being placed upon it. All the irritation, the galling pressure, the retention of heat, and other inconveniences resulting from bandages and plaster are thus avoided. The edge of the wound and the surrounding skin being uncovered, the eye can take cognizance of what is going on, and we can cut a stitch here and there when required, can keep the part clean, or take other measures, without difiiculty. Forasmuch as no dressings are applied, there are none to be removed. The suffering which used to be caused by the dressing of wounds after operations is got rid of. In many cases I do not touch the wound, except for the purpose of removing the sutures, from the day of the operation." We decidedly have more frequent union by first intention than when we were in the habit of applying dressings to the wounds. If suppuration takes place, an early and free vent should be aff'orded to the pus by cutting the stitches and opening the wound : and care .should be taken to keep the wound clean. " Large open wounds — that is. where portions of the skin have been removed, so that the edges cannot be approximated — are in our hospital (Cambridge) not unfrequently left exposed to the air without any cover- ing. A dry crust or scab forms upon them, beneath which cicatrization goes on, and we find that the healing often proceeds more quickly in this way than when the part is kept moist and the products of the wound are continually flowing away into the dressings. " Krlinlein tells us, after analyzing six thousand cases, that the open method has proved superior to all others, and demonstrates that the mortality of amputations, which ^Humphry, British Med. Jownal, October 27, 1860. 48 THE OPEy TREATMENT OF WOUNDS. by former methods had been fifty-one per cent., fell by the open treatment of wounds to twenty per cent. ; and Rose, who is the present director of the clinic at Zurich, follows Kronlein. He exposes all his wounds to a fresh current of air. which is maintained by means of open doors and windows. He regards stitches and bandages of all kinds as interferences to be avoided, and trusts to absolute rt-sf of the part after afrefid arrest of hh-ediiKj, to provision for thorough (h-ainuge^ and to ncnijudous chanliness. The wounded limb after an amputation is kept in one position on a cushion so protected by mackintosh that the discharges may easily escape into a vessel placed to receive them. Some of the practitioners of this system are somewhat inconsistent, since they advo- cate the frequent ablution of the exposed wound with carbolic water, or its protection by pouring over it the balsam of Peru ; and C. Thiersch adds that whether the wound lies quite free, or is covered with a piece of oiled silk, or with a water compress, cold or warm, does not appear to be of importance if only free escape of the secretions is not affected thereby; we may also, he says, add irrigation without changing the character of the dressing, as practised by Bardeleben, and the permanent water-bath may also be of use. Thiersch, moreover, adds that in cases of compound fracture and gunshot injurioi< — since the free escape of secretions is one of the most important points in their treat- ment — wounds may be enlarged by incisions, abscesses opened, counter-openings made, and even free openings into wounded joints or resection practised. The conclusions of the Moscow committee are also favorable to the practice, and mav be condensed as follows: The essential feature of treatment by ((erafioii, as this commit- tee calls it, consists in avoiding all local appliances for excluding air. and in placing wounds in conditions favorable for free and direct contact with the atmosphere. Lint and other such substances should never be used. Repair by primary union .should alwavs be sought for when possible. Catgut ligatures and metallic sutures should be employed. The advocates of this system believe that the '• Lister dressings" are injurious, but that the antiseptics employed counteract the baneful effects of the coverings. Summary. — The results of this open treatment are evidently satisfactory, and, judged by the essential points to which attention has been directed, the open treatment of wounds may be advocated, for it includes careful adaptation of parts after arrest of all bleeding and due provision for thorough drainage; but, on the other hand, It takes little care to guard against mobility of the wounded parts and disregards antiseptic applica- tions and precautions. The neglect is, however, probably due to the justifiable impression that if drainage be provided for there will be, in the deeper parts, no retained dead tissues or fluids to decompose or undergo chemical change, and that a free current of air upon the surface of the wound is the best guarantee against septic changes of its fluids. Lideed, Profes- sor Humphry clearly indicated this when he described how large open wounds by this system heal more ((uickly than when the part was covered and kept moist. Some of the advocates of this system believe the open treatment to be more adapted to wounds in which union by stcoudar// adhesion is to be expected, since they as.sert that if an open wound be maintained in a condition of perfect freedom from all irritating causes, .such as foreign bodies, dirt, and decomposing elements, granulations will form, and that suppuration is not an essential part of their formation. . For my own part, after a careful review of the whole question, I must regard the open treatment of wounds as being far superior to any other in which due provision is not made for perfect drainage ; but at the same time I fail to see its advantages over some others, and more particularly over that which I adopt, in which all the advantages of the open system are secured, and in which, in addition, the wounded part is effectually guarded again.st mobility and external injury, while at the same time due provision is made by means of a light antiseptic dressing against the possibility of any septic changes taking place at the surface as well as in the deeper portions of the wound. The recent investigations of Pasteur^ tend greatly to support the advocacy of this open dressing, since he claims to have proved '• that it is the oxgen of the air which weakens or extinguishes germ virulence." Pasteur's experiments confirm those of Dr. Downs and Mr. Blunt obtained in 1877, and those obtained by Tyndall in 1881, whereby the influence of sunlight in arresting the development of bacteria was shown. The treatment of wounds by ^^ irric/atifnr must be regarded as only a variety in form of the open treatment, since its essential advantage consists in the cleansing and thorough draining of the wounds of all secretions and impurities. The mode of carrying out this method will be described under the heading " Water Dressing." ' Acad, of Med., Lancet, November 6, 1880. sr/yiAL rni.A rMi.sr or worsDs. 49 III iruii^lint wiiiiiiil- Ioii;rliiiij.' or iiiihfalthy stiiiii|is or wounds this njodi' of tivatiiii'iit liy irrij.'atioii is viTV satisfactory. It lias been fiiijilov<*lished a pap»'r in the Eillnhiirgh Mnliml imd Snrr/irul Jnunml, .luly. in which he iKiinted out the evils of such old methods of dressing wounds as those of mundifyinir. di<:esting, incarniiij.'. and cicatrizin};, and recommended that wounds should he liirhtly dressed with wet lint or other simple dressing after their edges ha- .sr, helps better than anything else to en- courage in an injured or half-dying tissue, as well as in the secretions of a wounded part, chemical and fermentative changes by means of which septic poisons are generated or made to flourish, and from the absorption of which blood poisoning is known to follow. Water holding some antiseptic substance in solution may. however, be used, the antiseptic preventing or neutralizing the septic changes which the water by itself might encourage. In wounds, therefore, that are much complicated with contu.sion and laceration of parts, and to which hot or cold fomentations seem applicable, these medicated-water dres.sings may be emploj'ed, it being left to the fancy of the surgeon whether he shall use carbolic acid 1 in 20 of water, boracic acid 1 in 50, salicylic acid 1 in 50, thymol 1 in 1000, iodine tincture 1 in 80, or iodine liquor 1 in 160, or permanganate*of potash 1 part to 50. Value of Oily Dressings. — For my own pai-t. I have for years given up u.sing water as a dressing for wounds, whether with or without antiseptic substances, for I have found that oily solutions of the same substances have advantages' over the watery prep- arations which render them far safer and more satisfactory. Oily antiseptic applications are without doubt the best dressings for wounds which we possess, and of these one com- posed of terebene one part and olive oil three or four parts deserves, as already men- tioned, the preference. The Dry Dressing of Wounds. A dry dressing to a wound is to be preferred to one of which simple water forms a part, .since with it the sanguineous or serous exudations are more or less absorbed and rendered inert, and the surface of the wound is kept quiet and protected as by a scab from outside injurious influences ; whereas with a water dressing the injured surface of the wound and the wound-exudations are encouraged to undergo chemical and fermenta- tive changes by which the risks of absorption of septic matter or poison are much increased and the dangers of the simplest wound greatly enhanced. If the drv dressing be composed of some absorbent material, such as the absorbent cotton or lint, and impregnated with an antiseptic sub.stance. such as boracic or salicylic acid or iodoform, its efficacy will be increased, since the dressing, under these circum- stances, may be left untouched for some days, even for a week, and the healing of the part will not, therefore, be interfered with. Pvepair. as a consequence, will go on with greater rapidity and certainty, the secondary wound dangers will be diminished, and the ultimate issue of the case will be rendered more satisfactory. When a wound is nnall and the surgeon has no doubt as to the propriety of seeking to obtain its immediate union, the dry dressing can be recommended : for it. withoiit doubt, helps better than any other to bring about the " quick union " which is wanted. When the wound is Inrr/e or deep, the same recommendation cannot be made, and the dry dressings, if used, should only be so after every care has been taken to provide for the free drainage of the part. They should, moreover, only be employed when there is a reasonable hope of the parts healing by primary union. When a wound is much lacerated or cfinfmed. dry dressings are not applicable, since in such no surgeon would entertain the thoughts of repair being brought about by rapid union ; and where this hope cannot reasonably be entertained, the use of the dry dress- inirs should be discarded. In brief, in all wounds, small or large, when repair by '■ quick union " mav reasonablv be looked for. dry dressings are applicable, due provision having ALCnlKil.K- DUKSSLSC OF WOl'SDS. 51 been iiiailL' iur .'tViciciit draiiia;^*'. In all lacerated, contUHcd, or iJ«'t.'p wounds in wliich repair by granulation is to be expected, tbese dressings art- imt to be reconmiendcil. Earth Dressings. Karth as a ilrcssini: fur \v(iuiMi> lias (b»ubtless been used by savaj^e nations from an oarlv perioil of the wdrld's history, but it was first brouf^ht before tbe notii-e of surj^jeons by i)r. Addiufll Ih'ws.in <»f IMiiladelpbia, I'nited States, in 1.S72, and from bis wed the members of which talk of •■ antiseptic surgery" and claim for themselves the title of " antiseptic surgeons," as if it were applic- able to themselves alone, or rather to such of their body as have a belief in the germ theory as a cause of mo.st. if not all, the surgical ills to which wounded flesh is heir, who assert rather loudly and dogmatically that " antiseptic surgery" mu.st .stand or fall with the theory upon which their practice is based, that no unbeliever in the theory is likely to carry out the practice with any probability of success, since it is only \>\ a staunch believer in the theory that care and attention to every detail of treatment sufficient to bring about a good result is likely to be given. It is true, also, that the results claimed for this practice are great — very great, beyond all previous belief; that, according to these gentlemen, operations which in former times were looked upon as dangerous can now be undertaken with a '■• certninti/"' of success, and that others which have hitherto been regarded as unjustifiable are now legitimate and safe. In fact, the upholders of Asrixi'.i'i'ic ini'ji; Alios or wor.xns. 53 this tln'urv and :i(I(i|)tcr,s of this |tr:ictic«' maiiitaiii lliat i'X|ilnratiiry ami i> or nnrssfM. \\(H\J)s. 55 '• The /iiiiificiitinii (if till (ilr is ('tt('(!ti'(l hy means (if a spray of carhfilic acid. The s|>rav is product'd hy driving u rapid current oi' air tlirou^h the iiarnjw orifice of a hori- zontal tnhe, which is phiced over the orifice of u more or lesH vertical one. The air, rushing' over the opening; in the vertical tuhe, sucks the air out of that ; and if the lower end tlips into a fluid, the fluid is sucked up and e.xpelled iVom the narrow orifice in the fonii of fmclv-divided particles ctr spray. At present steam sprays are employed. The fluid ill the retort is 1--0 watery solution of carholic acid, and tiiis mi.xin^' with the Hteain iVom the Itoiler, forms a spray (d' ahout l-!>0. The spray is emj)loyeitiori I'nr natural rc|)air tu carry (lilt its silent work ; wlicrcas the same cxiicricncc tells lis witli no uncertain voice that the presence nt" a wound, however small, may chanj^e matters all round and turn an injury which, had it heeii siihciitaiicous, mij^ht have hecn n!<;arded as trivial into one of a serious and coni]ilicated kind. This I'act is widl exemplilicd in the difi'ereiit course asuallv taken hy a simple and a compound dislocation or fracture. What there is in tin- air that makes this with' difVereiice is now, as it evn, and attempts have heen made to assign to the presence of germs every evil influence, and tw regard tluMii as the cause of inflamniation and suppuration in every o|»cn wound. Hut this view can hardly be sustained; Inr, on the one hand, even in subcutaneous injuries, in which no air can get in, inflammation and suppuration may ensue, while, on the other hand, in even severe examples of fractured ribs complicated with (Miiphysema over the chest, l>ody, head, and extremities — in ca.ses in which the wholt; cellular tissue of the body seems infiltrated with unfiltered air under mo.st unfavorable circumstances — it is (|uite exceptional lor any inflammation of the infiltrated parts to take place, [ndeed, I may say that I have never seen an instance in which it occurred. Effects of Injection of Air into Tissues. — As corroborative evidence I may refer to some observations made in 1S.")7 by .Malgaigne, who, to test this f|uestion, made animals emphysematous with common unfiltered air and then fractured their bones, divided their tendons, and opened their joints subcntancoutili/ : though the parts operated upon were surrounded with air no inflammation followed. I may refer also to the experi- ments of Wegner (^Lan;/eiiback^6 Archives, vol. xx.), who injected air derived from the post-mortem room into the subcutaneous tissue of rabbits with impunity. For my own part, I am disposed to think it is not the mere exposure of a wounded part ttj the influence of air that does the harm, but its prolonged exposure, since it is certain that where wounds are sealed rapidly after the receipt of an injury, and are thus placed much in the position of subcutaneous injuries, repair goes on silently and well. Even bad compound fractures, when sealed early i'rom the influence of air, heal, as a rule, like subcutaneous injuries. Repair of Subcutaneous Wounds. — Tt may be accepted as a truth that sub- cutaneous Wounds art^ repaired much in the same way as open wounds that heal by quick or primary union — that is, when the wounded hard or soft tissues are brought or kept in contact, they simply reunite. The process of repair in both cases is a quiet physiological one not unlike that of development and growth. The action that attends the process is just enough to bring about the required result, but no more. AVhen it is excessive, inflammation is said to exist; and this inflammation, in subcutaneous as in open wounds, always ])revents, checks, arrests, or undoes the work of repair. In truth, the less there is of inflammation in a wounded part, subcutaneous or open, the more per- fect and steady is the reparative process. When inflamniation takes place in the site of some subcutaneous operation, the process of repair is likely to be interfered with, if not arrested ; for, as Paget observes, "the more manifest are the signs of inflammation, the less is the (juantity of theproper reparative material, and the slower, in the end, is the process of repair." To Paget and W. Adams in England we are chiefly indebted for our knowledge of this subject, and I shall use as much as possible Adamss description of this process, as published in 1800 in his work on the Reparative Process of Human Tendons after Divis- ion. His investigations have confirmed those of Paget, as well as added to our stock of knowledge. Where tendons are subcutaueously divided and drawn asunder, their repair takes place as follows : When such a tendon as the tendo Achillis is divided subcutaueously, the divided ends separate, in an infant for half an inch and in an adult from one to two inches, the degree depending much upon the healthy condition of the divided muscle and the amount of movement subsequently permitted in the ankle-joint. The reparative process begins by increased vascularity in the sheath of the tendon, which is followed by the infiltration of a blastematous material into the spaces between the fibrous elements of the sheath. This nuiterial exhi))its the development of innumer- able small nuclei, a few cells of large size and irregular form, with granular contents, or, 58 TREATMEyr OF SUBCUTAyEOl'S wouyDS. perhaps, with one or more nuclei and studded with minute molecules of oil. A blastema- tous material in which the cell form.s do not develop beyond the stage of nuclei appears to be the proper reparative material from which new tendon is developed. This nucleated blastema soon becomes vascular, capillary vessels havinir been seen in it on the eighteenth day ; the nuclei assume an elongated, spindle-, or oat-shaped form, and are seen, after the addition of acetic acid, to be arranged in parallel linear series. The tissue becomes grad- ually more fibrillated. and at last fibrous, a solid bond of union subsef|uently forming between the divided extremities of the tendon. The uniting medium is tough to the touch, but to the eye presents, even for at least three years, a grayish, translucent appear- ance, distinguishing it at once from the glistening old tendon. This new tissue remains during life, and has little tendency to contract subsequently. Adams's observations rather led him to the conclu.sion that the required portion of new tendon is to be obtained during a lengthened period of formation — that is, about two to three weeks — under the ordinary conditions of health ; but in paralytic cases, as in others of feeble health, this period may be doubled. Adams informs us, also, that the divided extremities of the old tendon take no active part in the reparative process during its earlier stages, although at the later the cut ends become rounded and their structure softened. They become enlarged and exhibit a tend- ency to split, and thin streaks of new material similar to that already described are seen between their fibres; the ends are joined by these means. At a later period the bulbous enlargement gradually diminishes. When a tendon is divided a second time, there is but little separation of its ends ; and this is probably due to adhesion of the new tendon to the neighboring fibro-cellular tissue, in which fact is found an explanation of the unsatisfactory results of second operations. There is no reason for believing that in the treatment of deformities by tenotomy direct approximation and reunion of the divided extremities of the tendon must first be obtained, and that the required elongation is afterward to be procured by gradual mechanical extension of the new connecting medium, as we would stretch a piece of india-rubber. When much blood is effused between the divided ends of the tendon, it has to be absorbed ; it acts merely as a foreign body in the part, and retards repair. Treatment of Subcutaneous Wounds. When rightly treated, these wounds are generally repaired readily, and. as Hunter asserted, without inflammation ; but when not rightly treated. " the subcutaneous action of a wound is not of itself a sufficient protection against inflammatory complications, and a clumsily-performed subcutaneous operation may be as dangerous as an open wound — sometimes even more so' (W. Adams). In the treatment of these as of open wounds there are. consequently, essential points of practice to be ob.served in order that good results may be obtained, and they are not unlike those which have been laid down for the treatment of open wounds — that is to say, the injured parts are to be placed as far as possible in a position of ea.se, and in which the contact of the divided tissues is assured when contact is called for. The parts are, moreover, to be fixed, by splints, bandages, or other dressings, in a condition of absolute immobility. The seat of injury is to be protected from all outside injurious influences and to be sup- ported by moderate pressure, and. what is more, is to be undisturbed, in order that neither by manipulation nor movement shall repair be retarded; for a subcutaneous wound is as susceptible to injury from mechanical interference as is an open wound. In treating the wounds made by the operations of subcutaneous surgery the same principles of practice are applicable, and they are well summed up by Adams as follows : The conditions requisite to render the subcutaneous operations exempt from inflam- mation are as follows: 1. That the knife used must be of small size; 2. That the oper- ation must be performed quickly and readily, with decision rather than force, and with as little disturbance to the soft parts as possible ; 3. That the wound must be immediately clo.sed and a compress and bandage applied, so as to prevent eff'usion and to support the part ; 4. That perfect (juiescence to the part be ensured for three or four days, and the dressing remain undisturbed. When all these conditions are strictly observed, it matters little whether large muscles or tendons or ligaments are divided, or even whether the larger joints of the body are opened. From all this it is to be gathered that to the treat- ment of subcutaneous wounds, whether of accidental or operative origin, •• position," VUMl'l.lCATloSS (,F worsDs. 59 • iiiiiiiohility. ' " pressure " to sii|i|Miit the |i:irt, and " time ' for repair to perfeet itself, are tiie four essential re(|uisite> In In- provided for. Complications of Wounds. On the well-l'ounded assiiuiplioii that a wound, wlien made int<» healthy tissue.s in a hi'althy suhjeet. will heal hy natural proees.ses if jdaeed in tlu; luost favorable position for ri'pair aiul //o/ interjirnl uit/i, it cannot well he disputed, when a wound doe.s not lieul thus kindly, that there must be some ob.staele or hindrance to its natural progress ; and this will doubtless be i'ouiul either in the nature oi" the wound it.self, or the mode in which it has been treated, or in the peculiarities of the subject of the wound, rir the sur- rouudinirs of the case. When the hindrance is due to the " uohik/ ifsc//"' or to it.s '' /rctUmcnf," it may be that some foreiLMi body has been left to irritate; that the h;c'morrha];re which ensued " primarily "' on its receipt has not been effectually arrested, and that a clot has formed between the edjres of the wound; that a •'recurring" bleedin/z has taken place within a day or so after the intliction of the wound and its first dressing from srune inifierfection in the treatment of the bleedinj: vessel ftr from excessive reaction ; or that a collection of serum has been allowed to form in the depths of the injured tissues. In most of these ea.ses the causes of non-repair are clearly referable to a want of care or skill on the part of the surgeon who has had the early treatment of the case, and must be set down as jtreventable causes. By want of care the edges of the wound may not have been properly adjusted or kept in apposition, the injured limb may not have been made immobile, and as a result spasmodic muscular movements and jumpings of the limb may have been excited ; or an insufficient provision may have been made for drainage, and. as a consef{uence. tlie wound may have been irritated by retained secretions, and po.ssibly made to inflame by the " teiision " which the retained secretions have produced. Harm may also have been brought about by the want of due attention to the dressing of the wound, and to its efficient protection from outside injurious influences. Other cause of non-repair may be the unsuitable character of the dressing u.sed or the position in which the wound has been placed. When the obstacle to natural repair exists in the ^^ suhjrcf of the womur' or in the surroundings of the case, it may perhaps be found in the age, temperament, or feebleness of the patient, as expressed by deficiency in the healing act, excess of pain, or inflamma- tion of the wounded parts, or, again, in the unhealthy atmospheric condition of the patient's chamber or residence, or in the unsuitable character of the patient's food, or in want of proper nursing. Under any circumstances, the ob.stacle to repair will be found in one or more of these causes, and it is for the watchful eye of the surgeon to discover the particular defect, in order that he may apply the proper remedy. It is well, however, for the student to recognize the fact that most of the causes of want of repair are preventable, and that they are, as a rule, due to some want of care in the primary dressing of the wound ; let it be repeated, therefore, that in all cases and under all circumstances too much care cannot be bestowed upon the management of fresh or recent wounds to carry out the essential points of treatment to which attention has been so often drawn. Consecutive Haemorrhage. — This form of bleeding is that which takes place within twenty-four or forty-eight hours after the reception of the wound. When it occurs, it is of little consequence whether it is to be attributed to some imperfection of the means employed to check the primary haemorrhage, or to the reopening, during the period of reaction, of a vessel which had been temporarily sealed by a clot at an earlier period of the case. It has to be dealt with, and with decision. When trifling in amount, it need not be regarded with anxiety, and more particularly when there is room for the blood to escape through the drainage-opening or tube, although even then it will be well for the surgeon to see that the wounded part is elevated and watched. If the bleeding vessel be a small or cutaneous one. these means will probably be enough ; if. however, the bleeding is persistent, or if the parts about the wound swell and become tense and painful, and more particularly if pallor of the .skin, feebleness of pulse, restlessness, and other signs of collapse furnish definite signs and symptoms of loss of blood, the wound must be opened, the clots turned out. the source of the bleeding looked for. and the vessel secured. At times the mere opening and exposure of the wound will arrest bleeding, and under these circumstances, when the bleeding vessel cannot be found, it is well to have the 60 COMPLICATIONS OF WOUNDS. parts exposed for a few hours, and eitlier to bring them together again when they have glazed and when most chances of bleeding have passed, or to leave them open to granu- late. The wound should, however, be left open under only exceptional circumstances — when the hope of quick union is very small or when such union is undesirable. When tlie bleeding vessel has been found, it is to be secured, and the wound treated as a fresh one and reclosed. At times, where oozing of blood is persistent, moderate pressure upon a wound does much good, and this may be well applied by means of an ordinary or a rubber bandage over a sponge or elastic antiseptic pad. Care must be taken, however, that the pressure be not too great. Secondary Hsemorrhage. — This is the form of bleeding which occurs after the lapse of two or three days. It may occasionally be due to the existence of the hjxjmorrhage diathesis, but is more commonly owing to some ulceration of the vessel in the line of ligation before the vessel itself has been closed by natural processes, or to some sloughing of the end of the divided artery or vein, with or without sloughing of the wound itself; to some imperfection in the means employed for the arrest of the primary bleeding, or to the accidental separation of a ligature. When it takes place in a wound that appears to be healthy, and in which the reparative process seems to have progressed in a satisfactory manner, the h;emorrhage will probably be found to have come from a vessel that has been imperfectly secured or the end of which has been irreparably injured, and under these circumstances, if the bleeding be profuse and evidently from a large artery, the wound must be reopened and the bleeding orifice sought for and dealt with as in the original wound. But if, on the other hand, the bleeding is not severe and the probabilities of the case are that the vessel is not large, the injured limb should be raised and moderate pressure applied ; for by such means there will be a good prospect of a successful issue being obtained. Should a recurrence of the bleeding, however, occur, and the effects of loss of blood show themselves, the wound must be reopened and the bleeding vessel secured. When the bleeding comes from a vessel which, with the sur- rounding tissues, has sloughed, it is a better practice to secure the vessel at a distance from the wound. When, however, the bleeding takes place in a case in which an artery has been tvcl In its contuiuiff/, the surgeon should delay reopening the wound, unless the evi- dence be strong that the blood comes from the supplying or afferent trunk, since experi- ence has fairly taught us that in a large number of these cases the blood comes from the lower or distal orifice of the ligatured vessel, and that under such circumstances it may be readily arrested by the elevation of the limb and well-applied pressure. In all cases, however, when the bleeding is recurrent and persistent, the wounded vessel should be looked for and secured either at the seat of bleeding or, when this is either diificult or dangerous, at a higher point. Pain. — There is no effect of wound or operation which varies more in degree than pain. In one case the subject of a simple wound will suffer much pain, while another individual with a severe wound will experience but little. Persons vary greatly in regard to nervous susceptibility; nevertheless, pain is under all circumstances a serious symptom and a grave evil, for it tends to depress the moral and physical forces of the strongest patient, and to exhaust even to death the feeble powers of the fragile. I am convinced that I have known pain to kill. In all wounds, therefore, operative or otherwise, it is important that pain should be guarded against ; and for this object surgeons can do much by care and forethought. The wounded parts should be rendered immobile, well protected, and so placed as to give rise to the least inconvenience or distress. The dressings, likewise, should be so regulated as to give comfort. In most wounds, and after most operations, some pain will be neces- sarily experienced, but as a general rule it will subside in the course of one or two hours. To relieve this symptom, however, it is well to give opium in some of its forms; and for this purpose, after an operation in which an auEesthetic has been used, it is an excellent plan to introduce into the rectum, before the 'patient becomes conscious, a suppository containing from one-third to one-half a grain of morphia. The anodyne begins to exer- cise its calming influence before the effects of the anaesthetic have quite passed off, and in some instances the action of the two drugs appears to be continuous. In other cases the subcutaneous injection of a ><}naU dose of morphia may be resorted to, or a full dose of the same drug may be given by the mouth. Under all circumstances, the early pain after a wound or operation is to be subdued. Causes of Persistent Pain. — When the pain is persistent and continuous after the healing process has progressed or perfected itself, some nerve complication may be suspected." It nnxy be that some nerve branch has been included in the ligature placed DEFECTS IS HE A Lisa PROCESS. 61 arouixl a vi-ssrl, <»r some iitrv»- trunk may Ix- >•) iiiv<»lv<(l in tlie cicatrix of" tlu- wound or so liountl to l)one or fascia as to be kept continually irritated or even inflamed, or it may be tliat no definite cause for the pain can lie made out. when the case, for want of better knowK'dtre. is ret:arded as neuraifric. When the cause of the pain can be dfttrmitn'd, tliis shouhl lie removed ; and whi-n no cause can be ascertained, the sur^'con may be justified in cuttin<: down on the affected nerve and stretchinir it or in subcutaneously dividinj; it, as suiis crlls. 'J'lii'V an- of a l»ri;rlit florid-ri'il colnr, and are tViiiL'i'il at their skin Ixmler witli tlie well-known thin hhie line which is so indieutive tit" healthy '• e'eatri/.ation.' Diirini: the whoh- ot" tin- healinj; process this appearance is luaintaineil. the only visihle elian^e heinj; the trrailiial pearance of the granulations themselves, and of the ''• thin hlue line" of cicatrization, the slightest deviations from the healthy tyjie; for while it is true that as long as a granulating surface is healing kindly the inference is correct that the subject of the " sore" is liealtliv, it i.s ei|ually certain, when the surface lias deviated from the healthy ]»ath. that there is .some- thing wrong either in the patient, in the part itself, or in its treatment. Thus, in a patient who is aniomic, the granulations will he pale and bloodless; an<] when this condition has been id" long >tantling, they will lose their small conical form and ajipear as coarse watery elevations. When there is any interference with the return of the venous blood from the granulating i)art. from either heart disease, the dependent position of the limb, or the improper u.so or bad application of bandages or other mechanical appliances, the granu- lations will appear '• congested " to variable degrees, and may even bleed. They may be so full of venous blood as to put on the purple appearance which suggested to the old authors the name of the '"juniper ulcer,'' the granulations looking blue or black as a juniper. When the ulcer bleeds, it is generally called Jtumorrhiijic. WJien the reparative power is feeble and granulations form, they will be of a pale, watery, (edematous character, and the discharge from them will not be normal pus. but a seropurulent tluid ; the granulations that form are of a weak type, and the sore then con- stitutes what is wrongly called a " weak" ulcer. When from some constitutional or local cause the reparative process is more deticient in force, the surface of the sore will either present a few ill-formed and feeble granulating spots or appear smooth and apparently wanting in granulations altogether, and look to the eye not unlike the tense mucous surface of the pharynx. In other cases, in which this deficiency in force is greater, the sore may present a greenish, dirty-colored surface, dis- charging an acrid or putrid substance which is clearly blood and serum mixed with the decomposing elements of dead tissue, the ill-formed granulation or granulative tis.sue in these cases dying superficially as soon as formed, for want of power to live and develop. In still more extreme cases of deficiency of power, what may have been a reparative process not only ceases to be so. but becomes retrograde ; what had been a co7istructive changes into a fleatructue force, and the tissues that should have been repaired break down and undergo molecular disintegration : the sore, instead of healing, becomes an ulcer, the new tissue dying from want of vitality. On the other hand, exi-fn^i of action may at times aifect a healing sore ; and when it does so, it aft'ects the granulating process as much as it has been .shown to do a wound in which quick union or primary adhesion is sought for. In the stage of irritation, or fhat in which the granulation tissue is simply overstimulated, overaction shows it.self in an excess of secretion from the granulating surface, in the shape of pus. and probably in some increase in the size and redness of the granulations themselves ; and when this is other than a passing condition from some temporary cause, it will soon become one of inflammation. When inflammation attacks a granulating sore, changes will occur similar to those which have been described as taking place ^vhen it affects a healing wound. Physiolog- ically there will be an arrest of the healing process, an arrest of seereti(»n from the granu- lations, and, if the action be lasting, a change from what had been a healing process to one of ulceration. The ulceration will be more or less rapid and associated with all the local and general phenomena of inflammation, such as redness and heat of the margins of the sore and the adjoining tissues, with pain and swelling. The degree and character of the inflammation regulate these appearances ; an inflamed sore or granulating surface presents as many different aspects as there are degrees or kinds of inflammation, for inflammation must be regarded as an accidental complication of the sore, and it may attack it in any stage of its progress or in any condition. At times the granulating force may be in excess and so act as to prevent repair. The 64 ON INFLAMMATION. graiiulatioiis .sprout above and beyond tlie inargins in which tlie " outifying " action is carried out. and appear either as elevated luxuriant growths in the centre of a sore or at the orifice of a sinus, or as overhanging florid granulations at the cicatrizing border. In these cases there is simply an excess of force, and this excess exliibits itself in fungous granulations. Again, a granulating wound, when of longstanding, may show on its surface or in its surroundings evidence of the existence of many constitutional or specific conditions — that is to say, a chronic sore in a patient who has a syphilitic taint may present features by which the presence of the syphilitic poison can be recognized, and a chronic sore in a scrofulous subject will manifest conditions which, if not special, as in the .syphilitic, will be clear enough to indicate sufficient feebleness and torpidity of action to suggest the existence of some general dyscrasia. On Inflammation. When a visible part is inflamed, there are four notable phenomena to be observed — namely, redness, heat, pain, and swelling — and these four symptoms are all associated with, if they are not directly due to, an active congestion of the capillaries, with more or less blood stasis of the inflamed tissue. This hypersiemia, or congestion, is, moreover, accompanied with cell changes in the seat of inflammation. There is likewise an arrest or annihilation of the functions of the part, and in the case of a wound an arrest of its repair, and later on destructive changes. Redness and heat are the most typical of these four symptoms, and heat is the more characteristic, increase of heat being, without doubt, the most important clinical local symptom of inflammation. The ^'' reditesit" may be localized or diffused, of a bright-red color or of a livid hue, the former tint indicating a healthy or sthenic, the latter (evidencing want of power) an asthenic, inflammation. It is clearly due to the capillary injection of the part, for in the sthenic form the circulation through the capillaries is more active than it is in the asthenic. in which the dusky congested livid color suggests blood stasis. The " increase of heat " is probably due to the accelerated flow of overheated blood through the hyperajmic tissues, as well as to increased activity in the tissue changes of the inflamed part ; but the local heat probably is never greater than that of the blood. John Hunter's sagacious utterance on the sul)ject one hundred years ago—" that a local inflammation cannot raise the temperature of an inflamed part above the source of the circulation " — being declared by Sanderson now to be correct both in fact and theory. The '■'■ swe-Iling'' or ''■hardness'" is to be explained by the nature of the tissue involved and the degree of blood stasis which is attained in the tissues. The serum of the blood, with its coagulable lymph, passively exudes from the gorged capillaries into the con- nective tissue of the inflamed part in the early stage of inflammation when the stasis is incomplete, and the emigration of the white blood corpuscles or leucocytes or proto- plasmic atoms follows when it is more so. Absolute death of the involved tissue takes place when the circulation through the capillaries is entirely stopped, the exudation from the slowly-flowing blood stream of corpuscular liquid being, in the words of Sanderson, *' the central phenomenon of inflammation." '" Ffxin " is a symptom which vai'ies much as to its character as well as to its intensity, and depends a great deal upon the amount of tension in the inflamed part. In inflamma- tion of the bone, periosteum, or of any part bound down by an unresisting fibrous tissue, such as the coat of the testis, the sclerotic of the eye, or the socket of a tooth, the pain is intense ; in rheumatism in which the fibrous structures of the joints are inflamed it is also marked. Probably it is caused by direct pressure on the extremities of the nerves of the stretched or tense tissue. We thus have redness, heat, streUinff. and pain as symptoms of overaction of a part, or what is called in flam mat ion, and they one and all appear to be direct consequences of extreme capillary vascularity of the tissue, whether that be the result of a wound or not. The blood stream through an inflamed limb has been demonstrated by experiment to exceed the normal flow in the proportion of something like four to one. These symptoms may manifest themselves in every degree of severity, their extent depending upon the intensity of the inflammatory action and the nature of the tissues that are involved. When a loose tissue is involved, the redness will be much marked and the swelling will probably be rapid, but the pain will certainly be slight, as the tension of the part is rarely .severe. When the connective tissue situated beneath a dense fascia is the seat of inflammation, or when bone is involved, the redness may be absent and the swelling com- Oy ISILAMMATIOS. 66 par;iti\ t'ly sli^^ht, since the peculiarities of the part affected prevent their being man- itesteil ; but the pain will probably be severe, fur the ten.si(jn of the tissues and the pressure ujton the nerves of the jiart will under such circumstances be necessarily {rreat. When the intiainniation is acM/r or rapid, all these syinptonis manifest themselves with great rapidity, and the results of the action are <|uiekly shown : when it is slow rri'at depression. It may show itself, therefore, only as a slii^ht febrile state, or it may be marked by the severest .symjitoms. •• Takin<.r, for instance, a case of severe compound fracture, without much hasmorrhage, in a person otherwise sound and stronjr, as a type of the affection, we find that before twenty-four hours have elapsed from the time of injury his \i( is destroyed from blood stasis, the infiltrating material, with the inflamed tissue, either undergoes destructive changes and breaks up — when what is known as " sitppKrafion " takes place — or the tissue as a whole or in part dies or " mortifies.'' The act of sirppifiiiflnn means the formation of pus and the.destruction of the inflamed tissue. Mortification. — The death of a part from inflammation means its moyV{/7ca/io».; when the action is a spreading one, it is called '■'■ govf/rene" ox ^'' sloughing phui/edsena" and the dead part thrown ofl" is called a " slovgh."' The death of bone is called " necro- .s/s," and the dead piece of bone a " sequestrum.'''' When a portion of tissue dies, the dead is separated from the living piece by a process known as that of " ulceration^' ulcera- tion of a part meaning its molecular death. When ulceration spreads, an ulcer is said to exist ; when this undergoes repair, it does so by granulation. "■Resolution," "suppuration." -ulceration," and "mortification" are the four events of inflammation. A use ESS. 67 Fk;. 10. Pus i'^ il'f |'r"«lii«i of iiiflainmation, and it consists of leucocytes, granules, and the lilnis of the inflamed tissue floating in serum. Cohnheim considers the leucocytes to be the sole source of j.urulent infiltration, and Strieker helieves that the f;erum in which they float abundant. Living pus is composed -f leucocytes and serum — li((Uor puris ; dead pus is made up of nucleated cells containing from two to five nuclei, granules, and serum. The leucocytes show their anueboid move- ments in the living, but not in the dead. pus. All pus is soluble in alkalies and has an alkaline reaction. Acetic action dissolves the nucleus of a leucocyte, but renders clearer the nuclei of a dead pus cell. The pus of a chronic abscess is not only dead, but undergoing degenera- tion ; its cells are large and full of fat cells. The fluid in which the pus cells float like- wise contains fat and granules in abundance. Accidental elements may be found mixed with pus under exceptional conditions, such as cholesterine plates and bone and other tissue elements : when vibrios and micrococci exists, the pus is undergoing chemical and fermentative changes. Varieties of Pus. — Pus, when thick and creamy, is known as '■ healthy." or laufl- ohh.Yn>. when thin and water}' and containing ill-formed pu.s-cells. it is called •' puri- form fluid," this condition being generally indicative of want of power; when it is blood-stained, it is called •' sanious ; ' when thin and acrid, •• ichorous ;" and when it con- tains flakes of curdy lymph. " curdy.'' Pus from the interior of a bone is oily, contain- ing, as Brandsby Cooper showed, granular phosphate of linie. Pus from the brain is often green, from the liver brown, the debris of broken-down tissue in different propor- tions and of different kinds giving these appearances. \. I'us corpuscles iiuatinitied •^■>0 diaineter- . h. >-jLn\e iiui'ie trausparent with acetic acid. ((. fell-wall. b. Nucleus. c. Nucleolus. (A/ler Leliert.) ABSCESS. A circnmscribfd collection of pus in any tissue is called an " abscess." When pus is not circumscribed, but diff"used in the connective tissue beneath the skin, between mus- cles, or along tendons, and iiifiltratea a part, diffused suppuration is said to exist, this latter condition always indicating want of power. Varieties. — An abscess is always the result of an inflammatory process. When it forms rapitUy and is associated with severe local as well as constitutional symptoms, it is known as an " acute abscess ;" when it is of slow formation and the symptoms attending its prog'ress are mild, it is called a '"chronic or cold abscess ;"' but there are many inter- mediate forms. In an "acute"' abscess the pus and broken-down tissue are circumscribed by the organization of the coagulable lymph and the parts around are infiltrated with serum, as indicated by pitting on pressure. In a 'chronic" abscess the walls are thick, from the organisation of the inflammatory products, whereby nature checks the extension of the disease and forms what surgeons of old called the " pyogenic" membrane, whifh is well exenijilitied in chronic abscess in bone. An Acute Abscess is invariably preceded by the constitutional .symptoms of inflammatory fever, and is accompanied by the usual local phenomena of inflammation, such as pain, redness, heat, and swelling. As the abscess forms the local symptoms become intensified, and perhaps concentrated : the pain alters in character, becom- ing at first dull and heavy, and then throbbing ; the fever symptoms also sub- 68 ABSCESS. side, or rather intermit, and a shivering fit or rigor more or less well marked, followed by heat, and possibly sweating, takes its place. The swelling, moreover, which was previously diffused, becomes more localized ; a soft, and possibly tender, spot, with a surrounding area of oedema, shows itself, and the parts covering it begin to thin. With the fingers of one hand steadily kept flat upon the swelling, and those of the other made to press upon it in another part, the walls of the abscess will be made to rise against the fixed fingers and a sense of " fluctuation " be given, this feeling of fluctuation indicating the presence of fluid, and, in this particular case, of pus. Under these circumstances the " pointing " of the abscess will soon take place ; meaning by this, the thinning of the part covering in the abscess in the direction of least resistance, the subsequent bursting or sloughing of the skin, and the discharge of the abscess cavity's contents. When the pus has been evacuated, the walls of the abscess, by their natural elasticity, fall together or collapse, the external wound closes, and the abscess either heals or contracts into a sinus or narrow canal, sometimes called a fistula. When the pus is daeii-seatcd.^ or bound down by fascia or periosteum, what is called " hurrourimj " takes place ; the matter makes its way between the soft parts, where the least resistance is met with, and opens either into a mucous passage, serous cavity, or joint. Abscesses beneath the periosteum constantly open into joints ; those beneath the abdominal muscles or within the abdomen, into the intestinal canal; and others in the extremities may burrow beneath the muscles and make their way to the surface a long way from the original seat of the disease. In disease of the dorsal vertebrae an abscess may burrow beneath the abdominal fascia, extend behind the sheath of the psoas muscle, Poupart's ligament, and deep fascia of the thigh, and open on the inside or outside of the thigh ; whilst in other cases it may pass into the pelvis and out again at the sciatic notch, and appear in the buttock as a "gluteal abscess." In disease of the lumbar vertebme an abscess may also form, burrow between the abdominal muscles, and appear in the front of the abdomen above Poupart's ligament. An abscess beneath the scalp may undermine the whole scalp tissue ; one behind the fascia and muscles of the pharynx may spread so as to cause a large post-pharyngeal tumor and cause death by suff"oeation ; while deep- seated abscesses of the neck may burrow into the thorax, and thus produce fatal mischief. These instances serve to show how pus, when confined beneath a strong membrane, will burrow along the cellular tissue of a part to find some outlet, and how necessary it is for the surgeon to be aware of the fact in order that he may stop the process or trace the cause of the disease to its source. The " diagnosis " of an acute abscess ought not to be difficult ; but when the abscess is chronic, the same cannot be said. Every hospital surgeon can record errors of diagnosis in which chronic deep-seated abscesses have been mistaken for cancerous or sarcomatous growths, and even for aneurism, and in which breasts have been removed for cancer which were the subjects of chronic abscesses. The knowledge of these past errors, it is hoped, will do much toward guarding against their future perpetration ; but the best security is caution and a diagnosis of the case by the process of reasoning by exclusion as laid down on pages 17, 18. Chronic (djscesses are of remarkably slow formation and give rise to very little consti- tutional disturbance or local symptoms other than swelling ; indeed, except mechanically, they seem to be of little annoyance unless they are secondary to some organic disease. Even then it is astonishing to what a size a chronic abscess will sometimes attain before it is discovered or complained of. In spinal cases this is often verified. In children, also, large abscesses form in the same quiet way. They are, however, never met with in the robust and strong. Abscesses connected with enlarged glands are peculiarly passive in their progress, and cause pain only when they begin to make their way through the skin. Those, again, which occur in chronic joint disease when the disease seems to be undergoing recovery show themselves in the same quiet way. Sir J. Paget' has described these as " residual abscesses." They seem to be a simple breaking down of old inflamma- tory products poured out in the cellular tissue during the more active period of the dis- ease, and which had failed to be reabsorbed or to become organized, mtich in the same way as a scar may break down after a fever. Absorption of Pus. — Pus may be absorbed, the serous fluid in which the cells float being taken up and the cells left to wither, these subsequently forming a pultaceous, and at a later date a cretaceous, mass. Clinically, however, pus may disappear altogether and leave no external evidence of its former existence. The fact is now clearly recog- nized by surgeons, and the' absorption of pus is constantly seen in the eye in hypopyon, * Clinical Led., second edition, 1879. ABSCESS. 69 as well as in the far:iii((' of |>t'iiustcal ciilarpements ami cliroriic siihciitaneous abscrssfs. 'I'liis result, liiiwt'vcr, fan nrilv he expeetc*! in (•hmnir cases wliicli arc not con- nected with ouble-€dced Abscess Knife with droove in < 'mri- some iodine or other antisc]>tic lotion. A (full-sized). piece of lint .soaked in terebene or carbolic oil, or a drainage-tube, should then be introduced into the abscess cavity to ensure the escape of any effused fluids that may subse((uently be poured out, and the parts in which the abscess exists should be made immobile by splints and bandages. By such treatment the abscess cavity may be expected naturally to contract, its walls to unite, and recovery to take place. During the formation of an abseess. fomentation, poultices, and warm-water dressings give comfort and may be used. They are only admissible, however, when suppuration and external discharge may be expected. When absorption is probable, as in certain residual or chronic abscesses, such means should not be employed, but rather ab.solute rest of the affected part and an absence of all irritating applications, tonic treatment and regimen being the chief general means upon which reliance can be placed. Use of Aspirator. — To help this desirable result, it is a good practice to draw off the pus frniu a chronic abscess with the aspirator of Dieulafoy. I have done this on many occasions with a good result, and no re-collection has taken place, but as often as not the fluid reaccumulated and a free incision was subsequently necessary. Whenever an abscess is opened, the incision should be free enough to admit of a ready outlet of its contents and to prevent any reaecunnilation. Treatment of Deep Abscess. — Wherever burrowing suppuration in a part can be detected, the sooner an external outlet is made the better, whether that burrowing be beneath the scalp, behind the pharynx, among the deep cervical tissues, in the thecae of tendons, between the layers of muscles of an extremity, or beneath the periosteum ; and this is more especially requisite when the suppuration occurs about joints or beneath the deep fascia, and particularly the fascia? of the perin^eum and anus. Superficial abscesses ought always to be opened. On the neck and face the line of incision should be made to correspond with the course of the superficial skin muscles or the lines or folds of the part, the deformity re.'julting from the cicatrix being thereby greatly diminished ; but in other cases the incision must be in the best direction for emptying the cavity. In all abscesses the puncture should be made where the abscess is '• pointing "' or the integument is thinnest, and where this indication is absent at the most dependent part of the abscess. The operator should always avoid dividing super- ficial veins and nerves, the position of the former being made out by intercepting the flow of blood through them by the pressure of the finger. Deep vessels and nerves should be carefully avoided, their anatomical position being always remembered. When ab.scesses have to be opened in the neighborhood of these important structures, the incision .should be made parallel to them. Mode of Opening Abscesses. — In opening an abscess a plunge ought not to be made. The operator >houl«l mark the point of intended puncture with his eye. then, introducing his instrument with decision through the soft parts into the cavity, make the incision of the required length by cutting outward as soon as pus oozes upward by the sides of the instrument. To do this sleepily is to give unnecessary pain, whereas to do 70 ABSCESS. it with a stab or plunge only causes unnecessary alarm. It should be done, as ought every other act of surgery, with confidence and decision, boldness and rapidity of action being governed by caution and made subservient to safety. To open an abscess that is pointing (or which has a cavity to be felt) by dissecting down upon it is a had practice, although in deep-seated abscesses which are covered by parts which it would be dangerous to wound, where .surgical interference is called for, such a method may be the best, extreme caution being requisite under circumstances of extreme danger. In such cases the surgeon should follow Mr. Hilton's method of open- ing deep-seated abscesses, which has been practised at Guy's for man}- years. In deep-.seated abscesses in the axilla, .•^ays Hilton (Li^ctures on Rent. 1803), " I cut with a lancet through the skin and cellular tissue of the axilla, about half or three- quarters of an inch behind the axillary edge of the great pectoral mu.scle. At this point we can meet with no blood vessels. Then I push a grooved probe or grooved director upward into the swelling in the axilla ; and if you watch the groove, a little opaque serum or pus will show itself. Take a blunt (not a sharp) instrument, such as a pair of dres.sing-forceps, and run the clo.sed blades along the groove in the probe or director into the swelling. Now, opening the handles, you at the same time open the blades, situated within the abscess, and so tear open the abscess. Lastly, by keeping open the blades of the forceps during the withdrawal of the instrument, you leave a lacerated tract or canal communicating with the collection of pus, which will not readily unite and will permit the easy exit of matter." In this way deep cervical and post-pharyngeal abscesses, deep abscesses of the thigh, leg, and fore-arm, may be fearlessly opened. After-Treatment. — When an abscess has been opened, it should be left to dis- charge by itself. Any squeezing or pressing upon the walls of the abscess is vxnneces- sary and injurious. In some a piece of oiled lint should be introduced between the edges of the wound to prevent their closure, more particularly when the deep fascia has been opened ; whilst in others of large size the introduction of a drainage-tube made of a piece of india-rubber tubing perforated at intervals may be re([uired ; in all. provision for drainage should be made. Tonics and good feeding are always essential elements in the treatment, .sedatives being given only when required. When a chronic abscpss requires opening — a question which in every case should be well considered — a free incision should be made into its cavity, its contents evacuated, and the cavity well washed with some antiseptic lotion. For this latter purpose a mixture of one or two drachms of the tincture of iodine to each pint of tepid water is the best ; a drainage-tube should then be introduced, care being taken that if air entei's its exit also can be guaranteed. The abscess should be wa.shed out daily. When the Listerian method of dressing wounds is employed, the abscess cavity must be opened under the spray, drained with proper-sized drainage-tubes, and covered with the gauze and protective. An excellent plan likewise consists in making a free opening into the abscess, previously covered with a piece of lint soaked in carbolic oil (one part of acid to twenty of olive oil), beneath which the pus flows away ; in this manner no air is admitted. In the subsequent dressings care must be taken to keep the opening surrounded with the vapor of the acid, and the lint should be removed only to be re- placed by a freshly-steeped piece. No pressure should be made upon the walls of the abscess for the purpose of empt3'ing its cavity without the opening being covered with carbolic oil. I have, however, used, in several cases, olive oil alone with e(juall3' good results. Suppurating ovarian and hydatid cysts may be treated as large abscesses and with considerable success. Empyemata or abscesses in the chest can also be dealt with on the same principle, by a free opening into the thorax and a free outlet for the pus. In these cases the drainage-tube is of great value, care being necessary to drop one end of it well down to the bottom of the cavity. The drainage-tube was suggested by M. Chassaignac, and is simply a small india- rubber tube perforated every half inch or so with holes to allow of the free escape of the pus. When large cavities are opened, they should be washed out at intervals with an iodine lotion or other antiseptic fluid, so that nothing like decomposition, as indicated by foetor. may be allowed. With this precaution, large suppurating cavities can be dealt with successfully. Hsemorrhage into Abscess Cavities. — When veins and large arteries are opened by ulceration into abscesses — an accident of occasional occurrence — they should be treated on the principle laid down in the chapter on hsemorrhage ; *'. e., if the bleeding ARREST OF ACUTK ISFLAMM ATKtS. 71 vessel he lariiiall, flic hreiiiniihaL'i- can easily )»(• arrested by pressure. Abscesses Associated with Enlarged Glands. — ciironie abscesses a.s.so- eiatcil with irlainliilar ciilMrLrciiiciit luol imt he i>|miiii1 iimhr >oiiie eircuiiistanees, because with cniistitutioiial trcatimnt they i)f'tcii Iaun- der hiuLself afterward had a similar successful result C" Lettsom. Lect.," Lunot. 1875). The late Mr. Moore of the Middlesex Hospital also acupres.sed the brachial artery with a good result. Previous to these cases, however, as early as 1813, Dr. Onderdonk of America ligatured the femoral in a case of wound of the knee-joint to check acute inflam- mation, and others since his time have followed his practice. It is a method of treatment certainly worthy of attention, inasmuch as to cut off the supply of blood to an inflamed part when too much is pa.ssing to it is sound in theory, and to do the .same to starve out the disease is equally scientific. In ele|)hantiasis Arabum the practice does not .seem to be without its good effect, and in acute di.sease it is certainly admissible. I well remember as a student observing, under the care of the late Mr. Bransby Cooper, a serious case of compound fracture of the leg complicated with a severe lacera- tion of the thigh and division of the femoral artery of the .same side. He was in doubt as to the practice he ought to follow, not knowing whether with the divided femoral the supply of blood would be sufficient to repair the compound fracture. The success of the case, however, proved that the fear was groundless, for repair went on uninterruptedly, and a good limb was the result. The patient was a man of middle age. In 1873 I also treateil with uninterrupted success a case of compound fracture of the humerus into the elbow-joint in a man where the brachial artery was obstructed, in which recovery with a movaltle joint was accomplished. With respect to the treatment of inflammation by the Jiijitnl compression of the main arterial trunks leading to the injured or diseased parts, it must be recorded that in 18G1 Dr. T. Vanzetti of Padua wrote a paper on the subject, which Mr. .*>. Gamgee has trans- lated in his work On FrnctnnH (1871). He was led to ap])ly this treatment to cases of inflammatory disease from its success in the treatment of aneurisms. He asserts that compression will cure every incipient inflammation, and check it even when advanced ; and he adduces cases of phlegmonous erysipelas and acute arthritis of the hand success- fully treated by such a process. He adds, however, that - in the treatment of aneurisms, as of inflammations, compression can never become a normal method until it be always and exclusively effected with the finger.' SINUS AND FISTULA. A Fistula is an unnatural communication between a normal cavity or canal and the outside of the body or with a second cavity or canal. A Sinus is a narrow and often tortuous suppurating tract with oidy one orifice. Amongst the Jisful^ there are the vesico-vaginal and the recto-vaginal fistula? in women : the recto-vesical in men ; gastric and biliary fistuhu, fa?cal and anal fistulae, salivary fistula, and urinary fistula ; there are also the congenital. 1»ronchial, or umbilical fistula. The acquired fistula? are either due primarily to some suppurative or ulcerative 72 STNUS AXD FISTULA. process or to mechanical violence, operati%'e or otherwise, and subsequently to a want of repair. When passages are close together, the fistula in some cases may be short and direct, whilst in others it will be narrow or tortuous ; the orifice of the fistula may vary much in size. When the cavity or canal is deeply placed or the inner opening deeply situated, the fistula may be a long narrow tract. When the fistula is of recfut origin and lined with granulations discharging pus. the walls will be soft, and will readilv bleed on manipulation. When old. they will be smooth and hard, or " callous."' and non-sensi- tive, and will secrete a thin, watery, non-purulent fluid. This fluid is. moreover, mixed with the contents of the cavity or tract with which the fistula communicates, the dis- charge tending to keep the fistula open. The exfermil opening of a fistula or sinus presents very different appearances. It mav appear as a direct or as a valvular opening, or may be depressed or raised. When leading down to a foreign body or to bone, the external orifice will be surrounded by weak granulations. Sometimes it may scab over for a time, and then reopen by the force of the retained fluid. The mtemal opening of a fistula mostly appears as a defined orifice. Causes of Sinus. — Abscess is the most common cause of ■•^imi.'ies or incomplete fistula?, the external communication failing to clo.se from defect in the healing power of the part, from some interference with the reparative process, from the want of a suffi- ciently free vent for the discharge of pus. from mu.scular action which forbids that amount of rest which is required for its repair, or. lastly, from the presence of some for- eign body introduced from without, or from dead bone or cretaceous inflammatory prod- uct from within. The TREATMENT of the diff"erent forms of fistula? is given in the chapters devoted to the special organs that are involved. In a general way, however, it may be asserted that so long as the cause of the fistula exists repair cannot go on ; so that in •' nrivory Jxstula,'* when stricture is the cause, the stricture must be treated before the fistula. In " aiu/V^ fistula, when the action of the sphincter ani foi-bids repair, its action must be paralyzed. In '• f^xal" fistula, when obstruction to the bowel is present, the obstruction must be removed. In •• salivary " fistula the salivary duct must find a natural outlet before its unnatural orifice can be expected to close. When any foreign body, tooth, or dead bone 4s keeping the sinus open, it must be removed. When a suppurating cavity at one end of the fistula continues to discharge, means must be taken to close it. When the.se objects have been achieved, attention may be directed to the fistula or sinus itself; and various are the means that can be employed for their cure. Pressure in recent sinuses, to keep the parts in apposition, by means of pads, strap- ping, or bandages, is sometimes of use. the muscles that move the part being kept thereby absolutely at rest. In stumps and after mammary abscesses this practice is very beneficial. Injection of some stimulating fluid, such as the preparations of iodine (either the tincture alone or diluted with one or two parts of water) will sometimes set up a healthy action : for the same purpose a .^eton has been used, and of all setons the small drainoge- tube is the best, or a narrow coil of rolled gutta-percha. The conten/ is sometimes of great use. and the galvanic is to be preferred. It can be accurately applied to the exact spot, and its heat maintained for any required time. It is generally most useful in small fistula-. Laying open the sinus is. however, as a rule, the surest plan, dividing it from end to end and keeping the sides asunder to allow of its healing from below. In superficial sinuses, where the skin is undermined, the thin overhanging portions should be removed; and this is best done with narrow scissors (Fig. 12). When done with a knife, the incis- ion is to be made upon a grooved probe or director which has been previously introduced through the sinus. This, however, may Fig, 12. often be done to great advantage with the wire of the galvanic cautery passed tlirough the sinus on the grooved director Mr threaded in an eyed probe, the surgeon >ubsequently making traction on the two ends of the wire, made hot by contact with the battery, and dividing the tissues with a sawing motion. The division with the cautery has this advantage — that the Probe-pointed .Sinus Scissors. surface of the sin US is SO destroyed that it nuust granulate. There is. conse- quently, less need of careful dressing ; and in old sinuses this is a point of importance, V WE lis ASH SOUKS. 73 fur their surt'accs arc so ciilloiis that tlicy rr(|iiiri' to lie scrajicil (ir othcrwiso renclered raw t(» cxcitt' granulations to Wwxu. The division of a Hstnia with a ligaliirt' is now rarely iierrornicd. ahhoiigli with one of " in«lia-rul»l>t'r " it is i'casiltU-. In • hh-cdcrs " it inifrht he caHeil for. Itut in these the win' id' the ;.;alvanie cautery is |)r(derahh> wlien it can l»e obtained. Oilatation e e.ifefiilly ele\ ntcd or bamlaged. ami t he general health attended to. The Indolent and Callous Ulcer. — Wlu-n there is still less power in the sore, no granulations I'orm ; the surface jtuts on the appearance of a piece of mucous mem- brane, such as that of the pharynx, the sore being then called '' imlnUnl.'' At tinu!s a few weak granulations are lound at one corner of its surface, but the greater part has a smooth and glassy aspect, with a thin and watery, but not purulent, secretion. Where the sore has existed long the edges will appear rai.sed and indolent, covered with a layer of epithelium, and very senseless. It then ac((uires the term " 'v//Ay»«," a callous sore being an indolent one of long standing. This inchdent sore is alway.s ready to take on a sloughing action on any slight cause, such as some general derangement of the health or the long assumption of the dependent position of the limb. It is common, indeed, to find the surface of the indolent sore '^ s/tjiu/hiiii/ " — not, liowever, from inflammatory action, h\\t h\m\ r.clremr inihth'ii(x ill tli.e (jidiinlatiiifj forcf. Under these circumstances the sur- face of the sore becomes covered with a greenish, often fetid, secretion, the granulations as they form dying. When the sore is large, this appearance is more general toward its centre or lowest part ; and as repair goes on the sore may cicatrize at its edges, where the granulations derive the full benefit of the vascular and nerve supply, while the centre of the sore still sloughs. In old people the margin of the .sore may slough in one part and heal in another. Authors have described this indolent sore in the old as atuHr. uher. These sores are very common, and are usually found in the lower extremities — often, too, associated with varicose veins; this condition of veins has, however, little to do with their origin, although it tends much to retard their recovery. These have been described by old authors as vnricosi' ulcers simply from the fact of the two conditions being often found together. Such are almost always found in weak subjects with a feeble circula- tion. Till' TREAT.MKXT o/' flipse iiidoinif sonn consists in encouraging the venous circulation of the i)art by its elevation, and by pressure where this cannot be secured by rest, and by local stiujulants and general tonic treatment. For pressure, there is nothing equal in value to the pure rubber bandage well applied, as recommended by II. Martin of Massa- chusetts in 1877 ( 7'/v^n.s-. of Ameririin Med. Association^. When there is little or no action in the sore, the application of one or more blisters to the surface is very beneficial, or blistering liquid may be painted over its edges. When the surface is sloughing, half an ounce of carbolic acid or six ounces of terebene to a pint of olive oil, with or without the extract of opium, according to the amount of pain, forms an excellent application. Where the edges of the sore are indurated and callous, so that the cicatrization and con- traction are almost impossible, the free scarification of the margin every half inch is often followed by a rapid change for the better, or two free incisions may be made on either side of the margin of the sore for the same purpose. During this treatment, if the venous circulati(ui is assisted by raising the leg higher than the hip, the utmost good may be obtained. In private practice, when the leg can be dressed daily, the ulcer, with its dres.s- ing, and the wliole limb may be covered with strapping. The strapping, therefore, ought to be good — not such thin material as that spread on calico nor thick felt strapping, but that spread on linen, such as is used at Guy's Hospital. The rubber bandage is^ how- ever, to be preferred to the strapping. When the sore is painful or the patient has an irritable pul.se. the beneficial effects of opium twice a day in a pill are very marked, and quinine, iron, nux vomica, or the vege- table bitters may be given, as the wants of the case indicate. The bowels also require attention, drachm doses of the sulphate of magnesia, with quinine, being a good aperient. When the sore is unusually large and there is little probability of the whole, from loss of skin, healing, fresh centres of cntijii-atioii should be inserted by transplantation. In this way I have brought about the cicatrization of a large sore of twenty-four vears' stand- ing in three weeks, and many others of smaller size in an equally short period : indeed, by this practice of skin-grafting, I believe the necessity of amputation in the more severe forms of this affection will be greatly diminished, for. hitherto, indolent ulcers that sur- round a limb have ever proved themselves incurable, amputation being their only remedy. 76 ULCERS AND SORES. All sores may inflame or become irritable, but there is an injlamed aore or nicer which is found in subjects with thin and fair skins who are in some way reduced in power or " out of sorts," either from irregular living, overwork, or bad feeding. It appears as a small superficial, inflamed, irritable sore with a raw-looking appearance, an ash-colored slough, or thick secretion over its surface, and discharges a thin ichorous fluid sometimes tinged with blood. The patient will complain of its exces.sive painfulness, particularly at night, and will dread its being touched. It will look red and angry, though superficial. A blow or a graze may have caused it, or a local patch of eczematous inflammation pre- ceded it, in which case it may be described as an ecznnatous nicer. The TRE.\TMENT of these sores is very troublesome, the skin being usually highly sensitive. They always want soothing, and the best lotion is one of diacetate of lead mixed with the extract of opium ; but this sometimes irritates, while the lead or zinc ointment gives comfort. At other times a cold bread poultice is the best application. In all cases the limb wants rest and elevation. In the eczematous sore, where the discharge from the eruption round the sore is profuse, the powdered oxide of zinc and starch, in equal proportions, may be used, or the surface may be washed with a solution of nitrate of silver in the proportion of ten grains to the ounce. Occasionally a solution of the extract of opium is the best lotion. Simple nutritious food, with a moderate allow- ance of stimulants, should be administered, but all high feeding is injurious. The general health mostly requires tonics of a non-stimulating kind, such as the vegetable bitters with alkalies, as the intestines are generally irritable. When the pain is severe, opiates and sedatives are indicated. In very inflamed ulcers the application of a few leeches at some distance from their edge occasionally gives relief. These sores are invariably obstinate. Authors describe a varicose nicer, but does such an ulcer exist? Many indolent sores are doubtless associated with varicose veins, and are probably indolent on account of this association; but how far they are really caused by them is a diff'erent matter, for vari- cose veins and ulcers of all kinds are constantly met with together. Of all ulcers entitled to the term " varicose," the eczematous has probably the most claim ; for cer- tainly eczema of the leg is a common consequence of varicose veins, and an ulcer the result of the eczema. Practically, however, it is well to remember that when varicose veins exist v;ifh an ulcer repair cannot go on favorably unless the venous circulation of the limb be assisted by position or pressure, and that where these varicose veins are present all ulcers or sores, if neglected, are disposed to become indolent. When an ulcer takes its origin from an inflamed vein, the term is applicable in a measure, but this ulcer has no special cha- racteristics. Sores that are prevented from healing by varicose veins must be treated by the ele- vated position of the limb or by the use of the rubber bandage or strapping, and in bad cases by the obliteration of the veins. Without this obliteration the treatment will of necessity fail ; whereas with it the sore may be expected to heal with the use of such general and local means as its nature may require. How fir it is right to heal an old chronic sore has not yet been quite decided. Older surgeons declared it to be inexpedient, as cases were met with in which apoplexy or some other alarming condition supervened. Modern surgeons, however, are disposed to ques- tion the explanation of these facts, and to look upon that practice as beneficial which removes any abnormal condition, local or general. Still, it is wise, when a patient has been in the habit of losing by discharge from the surface of a sore a certain amount of material which would otherwise have been used to maintain' the general powers, to cut ofl" the supplies in another way, to order more abstemious living, and to regulate the bowels by some saline water, natural or artificial, as may suit the stomach. Sloughing and phagedsenic sores are rarely seen except in connection with syphilis or hospital gangrene. In syphilis sloughing is found in the intemperate and ill- fed, and mostly in gin-drinking pi'ostitutes. It attacks any surface that has been made sore either from venereal contact or other causes, and it is marked by the rapid way in which the process destroys tissues, by the foetid character of the discharge, the great depression of power which is an invariable accompaniment, and the constitutional di.s- turbance. Opium in full doses is required for their tre.\tment, with tonics and good nutritious food. When these means do not control the ulcei-ation, the application of strong nitric acid with a piece of wood to the surface of the sore is often useful ; sometimes, too, the local application of iodoform, iodine, or bromine in solution is of great benefit. Fresh air is always indicated, and abundance of disinfectants, such as Condy's fluid, terebene, ULCERS AND SORES. 77 or i'ail>nlic iicitl in sonic oi' its iorms. Those sores arc mostly due to some feeble coristitu- tioMiil ('omlitiou, and not to a loi-al cause, altliou;;h at times the action seems local, when the applieation of .somc^ j)owerf"ul escharotic, such as nitric acid, is called i"or. Sir J. I'ajrc't descrilu'S rnlil, ulo rs: " They are like small inflammatory ulcers occurring spontaneously in the extremities, especially at the ends <.>{' the fingers or toes or at the roots of the nails. In some eases they are pnu-eded l>y severe pain and small garigrenou.s spots. They are in many respects like ulcerated chilblains, but they occur without any exposure to intense cold in patients whose feet and bands are commordy, «tr even habitu- ally, but little warmer than the atmosphcn; they live in. Such patients arc among tln)se who say they are never warm, and tiic skin of their extremities, uidess artificiallv heated, is to the touch like the surface of a cold-blooded animal. With this defect, which is com- mon in women, there is a small feeble pulse, a dull or half-livid tint in the parts which in healtliy pcnplc are rmldy. a weak digestion, constipated bowels, and scanty men- struatinii. " The cure of the ulcers and prevention of their recurrence lie in the remedv of these defects. Many tonic uiedieines may be useful, but the mo.st so is iron ; with it purga- tives are generally neces.sary — ?..ject, well-filled water beds and water (u- air cushions should lie employed. I have found a mattress divided transversely into three parts and a water cushion substituted for the middle section of great use. At other times the sections of the mattress may be simply separated for a few inches in the line of pressure. In spare patients, where the spinous processes of the vertebra? are prominent, thin slips of felt plaster placed vertically down the back give great relief, and the .same plaster applied to other painful parts is of value; cu.shions of amadou and well-adjusted pads of cotton-wool or spongio-piline are also always of service. When sloughing is present, a linseed-and-bread poultice with a solution of carbolic acid, of iodine. Condy s fluid, or charcoal sprinkled upon the surface is the best applica- tion, though a carrot or yeast poultice occasionally cleans the wound. When the slough has separated, some .stimulating lotion or ointment may be required ; and this is best applied on cotton-wool. The glycerine of boracic acid or a lotion of chloral, gr. x to the ounce, is the best application. In all cases where patients have to rest for a lengthened period, careful attention should be paid to keep the bed smooth and the sheets free from rucks. Corded or feather beds should not be used. The best is a horse-hair mattress placed upon a second or spring bed. MORTIFICATION, TRAUMATIC, ARTERIAL, AND VENOUS. The mortification of any part of the body signifies its death. When a soft part is " dying."' it is said to be in a state of '• gangrene ; " and when " dead," in that of "sphacelus." The dead portion is called a *• slough," and the process of separation the act of "sloughing." When bone is dead, the term " necrosis ' is employed, the dead portion being called the "sequestrum" and the process of its separation " exfoliation." The dead portion of any tissue is thrown off from the living by means of ulceration ; and when the slough has separated, the parts heal by granulation, as an ordinary wound. In the " sloughing phagedaena " the two processes of ulceration and sloughing are com- bined, the molecular death of a part, or ulceration, going on with the more general destruction of gangrene. Ca.ses of mortification may Vte divided into three main groups according their causes — viz. : Traumatic ; anaemic, or arterial ; static, or venom. Trmininfir gangrene includes cases brought about by external violence or chemical action, the term " direct " being applied to those in which the vitality of the part is destroyed at once, and " indirect " where the .same result is brought about by the inflam- matory action which follows an injury. Anaemic or arterial gangrene includes cases in which a part is .starved from the obstruc- tion of its artery, either from operation, accident, or disea.se. Static or venous gangrene includes those in which .stagnation of blood is cau.sed by the mechanical arrest of the circulation through the veins, complicated or not with secondary inflammatory action. In ^h and all of these groups inflammation plays directly or indirectly an important part. Moist and Dry Gangrene. — When mortification takes place in tissues that are filled with Idood. and more particularly with inflammatory fluids, "moist, hot, or humid gangrene " is produced ; biit when it take place in parts in which no such stasis exists, and where death of the tissues is the result of a want of arterial supply, " dry. cold, or chronic ganirrene " is caused. These two forms, however, are in a measure convertible, 80 MORTIFICA TION. the rapidity of the proce.s.s and the amount of inflammatory infiltration influencing the result. Tissues suiFering from defective nutrition, either as the result of some want of nerve supply or energy or of extreme debility the consequence of severe illness or other depress- ing influence, are more prone than others to mortify on slight causes. Direct traumatic gangrene is well exemplified in the destruction of skin from the contact of a corrosive acid, such as sulphuric or nitric, in bad burns and " smashes." It is also well illustrated in cases of extravasation of urine or faeces, and probably also by the action of some animal poisons. Indirect traumatic gangrene is also well seen in the integument after the application of a blister to a child or feeble patient, the blister being followed by inflam- mation of the blistered part and its subsequent death. It is more frequently met with, however, in bad compound fractures in which the limb swells a few days after the acci- dent and the skin assumes a mottled and livid hue ; loose blisters or phlyctenae of raised cuticle appear on the surface, containing more or less bloodstained serum, and the tissues become sooner or later cold and insensible, the temperature of the part often falling rapidly. The fluids from the wound, likewise, soon become ofl"ensive. blood-stained, and mixed with gas, and the tissues crepitate on pressure from its presence. Line of Demarcation. — The gangrene may be limited or spreading. When the action has attained its limit, a defined vascular line, " the line of demarcation," appears where the living tissues come in contact with the dead. In this vascular line ulceration takes place, and if left to take its course leads to the separation of the slough from the living tissues. By it soft parts, and even bone, may be divided, the granulations, as they spring up during the process of repair, materially assisting the ca.sting ofl" of the slough. AVhen the deeper tissues of a limb are thus afi"ected. they rapidly decompose and give rise to a horrible foetor, the extent of decomposition depending much upon the fluids in the part. Should the limb be exposed, the integument will dry, become black, and gradually wither, while the soft parts beneath will undergo decomposition. This process is rarely attended with haemorrhage, the vessels becoming obstructed by the coagulation of their blood during the sloughing action. In exceptional cases, how- ever, the vessels give way, the more rapid the sloughing action in the part, the greater, apparently, being the liability to bleed. Anaemic Gangrene. — The best examples of this group are found after the appli- cation of a ligature to a large artery, such as the femoral, for aneurism or injury ;. after the contusion or stretching of an artery (rA/e Fig. 134) or its embolic plugging. In all these instances the part dies by starvation from want of blood ; and the more sudden the act by which the supply is cut off", the greater is the probability of gangrene being the result. The more gradual occlusion of an artery, except in the aged, is more rarely fol- lowed by such a result, the collateral circulation preventing it. In the form of gangrene called " senile " it is very probable that arterial obstruction, the result of atheromatous arterial disease or of embolic plugging of the vessel from the breaking loose of some portion of the diseased arterial coats, is the immediate cause of the gangrene ; but the feebleness of old age, the degeneration of the tissues that have been badly supplied with arterial blood, coupled often with some slight local injury, are doubtless powerful agents in giving efi'ect to the process. One or more of these agents may be the true cause of the gangrene, but in the majority of cases they are probably combined. When the gan- grene is purely a dry withering or mummifying process, the cause is probably the simple want of blood supply ; but when inflammation coexists, the gangrene will be moist, the feebly-nourished tissues, either from injury or otherwise, becoming inflamed from some accidental cause, and ultimately dying. In the gangrene met with from arteritis or embolism in the young or middle-aged, the dry form is the usual, the parts becoming cold, bloodless, waxy, rapidly withering, turn- ing black, and then mummifying. When caused by embolism, the onset of the gangrene, or rather the early indication of the plugging of the vessel, is marked by a sudden shoot- ing or crampy pain down the extremity, this symptom being speedily followed by those of " arterial gangrene." When the occlusion of the vessel is gradual, this pain is not present and the symp- toms of gangrene are more chronic. Gangrene from " cold " may be the direct result of want of blood supply, or may be indirectly caused by the inflammation due to excessive reaction from cold ; this latter form is called secondary mortification. Gangrene following the use of the " ergot of rye " is dry, and follows precisely the same cour.se as when due to arterial obstruction. MnirniKArins. 81 Static Gangrene. — Tin- liot illu^tiatiuns lA' this varit-ty of ^aiifrrcno — which results fruni i>hgtnirhiiii — are sct'ii in cases ot" st laiiLruhitcfl femoral hrniia ; where splints are t(i(t tiirhtly applieil ; after the jirol()ii;;ed employment of the tonrnifjuet to cheek hii'inorrhaire ; in a ti;iht paraphyinosis ; in slou 82 MORTTFK 'A TION. the first onset of an inflammatory action tliat assumes a gangrenous form should he met by amputation ; while in a case less severe, where the injured limb has a good prospect of being made a useful one, an attack of inflammatory gangrene need not necessarily lead to its loss. Where the gangrene is due to the injury, it will probably be limited, and may so terminate that a good limb can subsequently be secured. Where it is due to constitutional, and not to local, causes, amputation of the limb will not arrest it; for the gangrenous action will in all probability attack the stump and continue till it finds a limit or destroys life. When the gangrene originates from a local cause, amputation is clearly the best prac- tice ; but when from a constitutional cause, it had better not be entertained till the action has ceased and a limit to the disease been formed. In military surgery there may be many reasons why this practice cannot be observed, for all conservative surgery or treatment based on expectancy has to be sacrificed to the exigencies of the moment. How, then, it may be asked, is spreading gangrene to be treated ? I reply. By main- taining the part as free as possible from all foetid dischai'ges and employing incisions when necessary to secure these ends, by local cleanliness and the use of antiseptic applioia- tions, and internally tonics and good food. Under this practice, when nature is strong enough to check the progress of the disease, a limit to its extent will be formed and the local affection will be amenable to treatment ; but when no limit takes place, death will ensue, which amputation would not have arrested. When 'amputation is deemed necessary on the arrest of the action, the limb should be removed as close as possible above the diseased part. There exists no necessity to saci'i- fice any tissue, and much less a joint, to make an amputation neat. The only point for consideration is that the diseased tissues should be avoided, but beyond these no healthy structures should be sacrificed. The Treatment of Anirmic or Arterial Gangrene. — The surgeon's object should be to prevent its exten.sion, and to assist, when called upon, the separation of the parts. To carry out the first of these, the mortified parts maybe wrapped in some lint dipped in simple or carbolized oil ; and the whole extremity should be raised, to encourage the venous circulation, and surrounded with cotton-wool, to maintain its warmth. A liberal allowance of bland nutritious food should be given, aided with stimulants and tonics to assist digestion ; the circulation, too, should be sustained, though anything like overstimulating is reprehensible. Opium also may be given to allay pain, the patient being kept gently under its influence. Where small parts only are implicated their sepa- ration may be left to nature, but where hands or feet are involved in the gangrene the surgeon should assist nature's processes by amputation above or about the line of demarca- tion as soon as indicated. AVhen a limb dies from embolic plugging, occlusion of an artery, or from the eff'ects of ergot of rye, amputation may be performed as soon as the line of demarcation has been indicated — that is, provided the general condition of the patient be such as not to forbid it. In "senile grangrene" the interference should be of the mildest kind. Where '' sphacelus" takes place after the application of a ligature to a large artery, early amputation is sometimes called for, it being at times wise to remove the limb above the line of ligature rather than to wait for nature to indicate the point, particularly when the limb is fcdematous from blood .stasis and infiltrated with inflammatory products, this practice saving much constitutional disturbance and economizing power. In cases, how- ever, in which the gangrene assumes the an; wuiiikUmI or iiijiircfl parts, and chiefly ill ovorcntwtU'd, hadly-vciitilatcd, or ill-drained hospitals. At tiiiu-s it pn-sciits itself as if jroiienitL'il ill a ward too closi-ly lillc([ with patii-iits who have sup[»uratiii^' wounds; at others, as if eoiiveyeil into a ward Ity the introduetioii of a sloii<:hiii^ or fital gangrene. The broad, hard infiltration so soon following the operation might seem to be due to contagiftn by means of the dressings employed, but this was scarcely probable. In its sporadic form it especially appears to affect the subjects of septic or pyjemic disease, 84 ERYSIPELAS. and perhaps certain conditions of tlie secretions inclined to coagulation may favor its production. Treatment. — Abnndwiec of fresh air, as maintained by a constant current allowed to pass through the ward or room, is most essential, with isolation, the free use of anti- septics and close attention to all sanitary measures. During the early stages of the dis- ease irrigation seems to be the best local treatment, with the removal of oil slutit/Iis and jnitrescent material by carefully cutting the existing slough with scissors or scalpel aided by the dressing-forceps and mopping the surface of the wound with cotton-wool or tow, thus tlioroiufhiij cl<;a)iniiig tlu' whole surface of the ico»narticularly when terminatintr unfavorably, the pul.se will be small and weak. The temper- ature at the first onset of this di.sea.se, as a rule, ri.ses rajiidly, and in its decline falls as fast (^vidi tigs. IM and 14 ). When the temperature remains hiirh, a bad prognosis should be given. C. de Morgan, Nunneley, and II. Bird assert that if the pulse rise in fre«|uency after the sixth or seventh day it is a very bad sign. I cannot, however, endorse this observa- tion, although, as the end of the first week is about the time that complications appear if they occur at all. it may pos.sibly Vje correct. Frank has pointed out that when a patient has had febrile .symptoms for sonte hours attended with pain, tenderness, and swelling of the lymphatic glands of the part, there is Fir;, l:;. Fir;. 14. BSISBBBSHI Thermograph of erysipelas supervenin.: upou removal of the tarsal bones after the traumatic temperature had subsided, showing rajiid elevation of temperature — nearly 5 degrees— at the onset of the disease and steady fall during convalescence. Case of H B., set. 32. ■■■■■■■g ESSSlBaBDBDBBHDB ThermoLTaph oi erysipelas in man. at. ■_".', after re- moval (if parotid tumor. Operation iday li fol- lowed by slight traumatic fever (day 2) anil steady fall in temperature. Klevation of temperature (day 4i when blush first became visible, and steady rise for three days during increase of disease, with rapid fall on its subsidence. Convalescence on eleventh da v. no doubt that erysipelas is coming on. Chomel held the same view, and Campbell de Morgan relates " that Busk is so convinced of the invariable occurrence of affection of the glands before ery.sipelas appears as to consider it a pathognomonic symptom," and he believes that, although the blood became affected, the actual primary seat of the local inflammation was in the absorbent system. Sometimes swelling and excessive tenderness of the glands precede by many hours the appearance of a blush on the skin. These views accord well with those which Dr. Bastian brought before the Pathological Society in 1869, based on the po.st -mortem examination of a man who died from erysipelas in a state of delirium and stupor. In this case, finding the small arteries and capillaries of the brain plugged with embolic masses of white blood corpuscles, he suggested this con- dition as the cause of delirium. He stated " that the blood change is a general one, and through every part of the body this blood is carried with its rebellious white corpuscles ; so that we may expect that in all organs alike the same obliterations of small arteries and capillaries take place." Thus, when those of the liver are involved jaundice may be produced, and when those of the kidney albuminuria, these conditions being occasionally found in erysipelas. If we accept Dr. Bastian's ob.servations pathologically, and look to the condition of the white blood corpuscles for an explanation of many of the phenomena of ery.sipelas, we may fairly admit the inference from clinical observations respecting the absorbent system to which Frank and Busk have called our attention, for the glands of this system and the white blood corpuscles are generally recognized as having a close relationship. These views receive much confirmation from the pathological observations to be read on page 87. Local Symptoms. — In the simple form of cutaneous erysipelas mere excess of vascularity, as indieatcd by the vivid redness of the part affected, is the chief local symp- tom, and with this there is a sensation of heat or tingling in the part, and in rare instances 86 ERYSIPELAS. the formation of small vesications. Tho border of inflammation is invariably well defined. The redness, wliieli spreads rapidly, disappears on pressure, to return directly the pressure is removed ; but there will be no pitting of the parts to indicate oedema. In a day or two these syniptouis will subside or disappear, and the cuticle will descjuamate. In the 7iiorc sfvn-c form of cutaneous erysipelas the vascularity of the skin will be as intense as in the simple, but it may be more livid. It will, however, be associated with some perceptible thickening of the parts, tfhe inflamed tissues feeling raised on pal])ation. Where much cellular tissue exists, as in the eyelids or scrotum, oedema will rapidly show itself. Small or large vesicles may likewise form on the surface, containing either a clear serum or a blood-stained or sero-purulent fluid, the latter form indicating great depression. In the head or other parts where the skin is tight the feeling of tension is very great and the surface looks shining, the features being altogether obliterated. There is rarely, however, nmcli ])aiii. Course and Duration.— The disease runs its course in al)()ut ten days. j)uring the first three or four it spreads, and, having reached its height, declines, the redness and swelling gradually subsiding and the .skin des(juainating. In some cases a local suppura- tion takes place, and tliis is always to be sus])ected when any local redness remains after the subsidence of the inflammation. In the eyelids and other parts containing loose cellular tissue such a result is common. In the cachectic subject the disease is always more (edematous than in the healthy. When it attacks a wound, the general symptoms are the same, but the local consist in arrest of secretion in the part, then ulceration, and later on, where union has existed, disunion, stumps and wounds sometimes reopening and discharging a thin ichorous fluid. After the disease has subsided repair is usually .slow, but at times it goes on healthily to complete recovery. Pr()(JNO.>>is. — Simple erysipelas, unless in the feeble or cachectic, is rarely a disease of much danger. In free-living subjects, and in others who have l)ad viscera, it is, how- ever, a dangerous affection, lighting up latent disease that often proves fatal. When it attacks the scalp after head injuries, it is exceptional to find it followed by bad conse- quences. Where the erysipelas attacks the mucous lining of the throat, fauces, or larynx, it may, from mechanical causes, threaten life. In some cases the disease will affect different parts of the body consecutively or leave one spot to attack suddenly another. Such cases usually indicate want of power, and too often are found in those who have some organic disease of the kidney or other excre- tory org.iii. Diffuse cellular inflammation may clinically be looked upon as a form of ery- sipelas, the disease attacking primarily the cellular tissue instead of the skin. It is cha- racterized by the same diffused form of inflammation and by the same atonic character. It is, however, more frequently the result of' some local injur}', such as a punctured or dissection wound, than is the simple form, and it is even found in patients from whom no such history can be obtained. It is generally as.sociated with absorbent inflammation and glandular enlargement. The disease appears as a diffused swelling and induration of the cellular tissue of the part aflected, the tissues feeling infiltrated and brawny and the skin tense from over-dis- tension. When suppuration or sloughing of the cellular tissue has taken ])lace. fluctua- tion or crepitation will be detected or the parts may feel boggy. The skin, if not pre- viou.sly inflamed, will now participate in the disease; it will inflame, ulcerate, or slough, to permit the escape of the pent-up pus or sloughing cellular tissue. When resolution takes place at an early period of this affection, the skin may escape uninjured; but such a result is rare. The constitutional symptoms attending these changes in the cellular tissue are always those of great depression. The febrile symptoms will be of the typhoid type, the pulse feeble, although rapid from the first, and the disposition to sink very marked. Profuse sweating is an early and constant s3'mptom. Delirium also is sometimes present. Vis- ceral complications are, as a rule, the cause of death, the connection between this affec- tion and py;\!mia being very close. Phlegmonous erysipelas is a combination of the two former. It is fiir more serious than the sinqde, and as much so as the cellular inflammation. It is characterized by a dift'used inflammation of the skin anf the part, tin- skin prescntiiifr cryMipolatous redness of a dusky hue, and the houiidary lietweeii the intlaiiied and utiinflanied skin heirijr ill-niarki'd ; outside the limit (»t' the rechiess the skin feels unnaturally Hrni. and the edlular tissue beneath as if infiltrated. To the tinj^er the inflamed ])arts feel more solid and pit on pressure. Reso- lution is almost unknown as a termination of the disea.se, one ca.se differin;r fr(»ni another oidy in the extent of the destruetion of tissue with which it is accompanied. As the di.sea.se protrres.ses. and the t-ellular tissue beneath the integument becomes infiltrated with inflammatory pnnlucts, the skin will be made tense and cease in pit ; uni- form hanlness of the tissues will irive jdace to a .sen.se of fluctuation, as of fluid, or to a boiriry. (juajrsy. crepitatiuLr feel of slouirhiiii: cellular tissue. If the case be left to nature, the skin will V)ecome thin and ulcerate in jiarts or slough in masses, to give vent to the pent-up and sloughing tissues. Phlyct;cn;e will also appear over the dead portions of skin, as in other forms of gangrene ; while the pus and sloughs which escape are always fietid. In bad cases the whole cellular tissue of a limb, with large portions of integument, in this way may die, bands of skin held down by fascia being left, which during recovery will become the centres of cutification. In the ordinary run of cases this dift'used infiltration of the cellular tissue is confined by the fascia to the subcut^meous ti.ssue. but in .some instances the cellular tissue that separates the muscles becomes involved, when the case assumes a far more .serious a.spect; for the suppuration is then of a burrowing kind, and the sloughing is more exten.sive. The prospect of recovery with a useful muscle becomes also very slender, for muscles and tendons may not een kindly drawn up fur nie liv Dr. J. F. Goodhart after a careful analysis of the post-mortem records of the hospital. They admit of being classified as h/col and general^ the former including all those morbid changes which occur in the primary focus and in the surrounding parts directly extending from it ; the latter, the various alterations of blood or tissue found in any secondary foci or in the system at large. The local changes vary according to the severity of the disease and the rapidity with which it causes death. In the slighter forms, where it has not been the immediate cause, but has supervened as an intercurrent affection in the course of some other disease, it may often happen that no morbid appearance is visible po.st-mortem indicating erysipelas. Again, the skin alone may be affected either with a mere faint purple discoloration or with slight oedema, or the cuticle may be raised into bulht or separated more or less around. In more pronounced cases, the areolar tissue beneath the skin and along the tendons and intermuscular septa has numerous minute ecchymoses and extravasations of blood in it and is often soaked with yellow serum or gelatinous matter, apparently produced by a delicate fibrinous coagulum : in the more prolonged or in severe cases the serum is replaced by healthy pus. Ecchymoses in the subcutaneous areolar tissue are very common, even in cases where death has been very rapid and no other morbid appearances are seen. It is charact*?ristic of the further changes that there is no tendency to the limitation of the disease around the primary focus ; the pus or serum leads to the formation of no abscess sac, but spreads along the subcutaneous tissues and intermuscular septa, sometimes even making a complete dissection of some of the muscles. There may or may not be phlebitis in the parts. Where it exists the interior of the veins affected is discolored and filled with grunious chocolate-colored fluid, while the inner surface of the vein-wall is rough from the inflammatory processes it has undergone and the adhesion of small particles of clot. Where the disease has existed some time a tube 88 ERYSIPELAS. of semi-organized clot may line the vein, and within that -nill he found the broken-down clot, which it is often impossible microscopically to distinguish from pus. It is quite as common, however, to find the vessels unaffected as to find them plugged, if not more so. Pus may even run along their course, sometimes apparently in their adventitia. or more often immediately outside it. and still lead to no clotting. On micro- scopical examination in these cases the pus is seen to lie in smooth-walled channels which in all probability are lymphatic spaces (^suppurative lymphangitis). Affection of Glands. — The neighboring lymphatic glands — >'. e.. those in the groin if the di.-La.-e be >ituated in the leg, the axillary if in the arm — are usually swollen, red, and ecchymosed on section, and are frequently surrounded by the same kind of serous fluid as is found in the immediate neighborhood of the primarily diseased tissue. The tissues of all the diseased parts are said to be crowded with small vegetable organisms called " bacteria. " These constitute the local changes. It may be as well to add. j)er- haps. when erysipelas affects the scalp, that a yellow color of the vault of the .skull is often observed, and also that suppuration between the bone and dura mater and suppura- tive arachnitis and meningitis are not very unusual sequences. About the neck it may be followed bv cedema glottidis. and occasionally by pericarditis or suppurative inflam- mation of the mediastinum. The morbid appearances in the system at large are similar to those found in septicae- mia from other cau.ses — viz.. ecchymoses about the pleura and pericardium, a fluid and sometimes treacly state of the blood, congested kidneys, and a softened state of the liver and spleen. So soft, indeed, is the latter organ that were it not for its capsule it would at times lo.se all shape. The blood has been said to contain bacteria, but I have never found such during life, though they are sometimes present when the blood is examined some hours after death. In addition to these general changes, separate foci of diffuse cellulitis are found — in both fore-arms and in the calf of the leg. for instance, after a primary erysipelatous state of the scrotum : and in at least two recorded cases a similar diffuse cellulitis or myocarditis has been noticed in the muscular wall of the heart. Patients with erysipelas are also liable to suppurative peritonitis and pleurisy, which, though commonly so. are not necessarily determined by the presence of a neighboring wound. A subject of hernia or ovariotomy at a time when erysipelas is rife will be likely enough to die of suppurative peritonitis ; while another who has undergone an excision of the breast may die of a similar form of pleurisy without showing any external evi- dence of erysipelas. A wound, however, is not necessary. For example, in a post-mortem made not long since a lady about sixty had been nursing a friend who died of some febrile affection called •• low fever."' Within a few days she herself became exceedingly ill. and died quickly. The inspection revealed what had only been evidenced by the faintest blush on the skin during life — viz.. an early suppurative inflammation of the cellular tissue of the right axilla and pectoral region, and pus on the surface of both pleurse ; all this without any external wound whatever. As occasional causes of death in erysipelas may also be mentioned acute lobar pneu- monia and a diphtheritic sloughing of the mucous coat of parts of the bowel ; while, to complete the history, it must also be said that at times when erysipelas is present in a hospital or its neighborhood not only are cases of pyaemia, with its known manifestations, such as abscesses in the viscera and pus in the joints, frequent, but patients suffering from chronic suppuration become feverish and die without, it may be. any adequate cause appearing in the viscera. In this description of the pathological appearances found in erysipelas no attempt is made to distinguish between it and cellulitis. The morbid changes in both are the same, and it is as impossible in the deadhouse as at the bedside to. separate the two. Treatment. — The disease in all its forms is essentially an fitonic one ; consequently, nothing like ■• antiphlogistic " remedies are to be entertained, and in the simpler forms which have a tendency to run a definite course the practitioner has merely to guide his patient through the attack and to ward off whatever might prove injurious. "With these objects, when the' patient's powers are eood and no indications of feebleness manifest themselves, a mild aperient or purge, to clear out the bowels, with bland nutritious food. such as milk and beef-tea. is probably a sufiicient remedial means, the disease on the third or fourth day attaining its height, and then declining. Should anv feebleness or want of power appear at the beginning or during the cour.se of the disease, tonics are indicated ; and of these iron seems the best. The tincture of the perchloride in half-drachm doses, or more to an adult, frequently repeated, with or f.Rysirh'LAs. 89 witlidiit ((uiiiiiu' or stryliriiii. acts at fiiiics liki- a ••liariii. and douhtlcsis often cuts short the disease. Its iisi' was iiitroduci'(I to liritish siir^reoiis hy I'r. II. IJeli of Kdiiiljur^rh in is.")!, ahhoiiiili V(d|ieau in ]X[l had previously declared its value. In the earliest staj^e of the aflet-tion, when the first |iat<-h of intianiniatidn appears on the skin or around a wouimI. an emetic may at times aliruptly (dn-ck the attack. When I'ood cannot he taken, stimulants must he suhstituted ; and it is well to introduce inid llieni, and particularly int(» stout, some essence of meat. The form of stimulant must depend upon circumstances, but, as u rule, that which the patient has hc.cu in the hahit of takinj; is the iie>t. When hraiidy is ^iven, it slnjuld be nii.xed with milk or efrainfiil. relief is readily given by following the practice of 8ir R. Dobson in puncturing the skin with a .series of small punctures, oozing of blood or serum being encouraged l)y warm applications. In erysipelas of other parts the application of the tincture of iodine is to be recom- mended. Mr. Luke thouglit highly of the free use of collodion applied over the part; Mr. Higginbottom, of a solution of nitrate of .silver twenty grains to the drachm of water ; others, of the tincture of the perchloride of iron. I have employed at times all these, and prefer the tincture of iodine to any ; but none of them have any certain power of arresting the progress of the di.sease. Some American surgeons .speak strongly in favor of the application of a solution of bromine on lint with oil-silk over the whole, and quite recently the subcutaneous injection of a solution of carbolic acid has been highly spoken of. Mr. Harwell has advocated white paint. The local treatment of the cellulo-cutaneous forms of the disease must be conducted on tlie same principles as the simple, but as soon as anything like tension of the integument appears incisions should be made deep enough to allow of the escape of the eff"used serum from the cellular tissue beneath the skin, and long enough to relieve the tension of the whole. Some, and amongst them the late Sir W. Lawrence, recom- mended the incision to be free, so as to extend the whole length of the affected part. Others, among whom I claim a place, prefer a greater number of limited incisions. The.se limited incisions answer the same purpose as the long, and are not attended with so copi- ous a hicmorrhage or with so great a risk to life. Even after these the bleeding is at times profuse, but it may generally be readily arrested by elevating the limb and by temporary pressure. When suppuration and sloughing exist, the surgeon must let out matter as soon as formed ; for there is little doubt that the disease is kept up by its presence. The open- ing into these abscesses should be free, and their cavities kept clean by careful wa. rV.KMIA. 91 Its TiiKAiMKNT is siiuiilr Saline jiurj^ativcs, tonics, ami a can'rully rc^rulatcd diet are, as a riili". .siiniricnt in a L:iii.ral way, and the ajijiliiatioii nf a Ifa3 III ran; cases iiiiciiiisciousness (Vnin wliidi tin- ]i;iti(iit i;iii lie r<>u>cc| only tu ri-l:i|i> ariiti' doliriiiin and mania nccnr. Wlu'ii tln' I's/iiitifnri/ niyniis aii' iiivulvcil — ami it may ln" statfil that tlicy arc so far mnn- fVi'«nii'iitlv tliau any other — dittiiMilty of h|•(•athillu^ with a har.-h dry coii;;h. and in'rhaiis viscid Idood-staiiiiMl s|mtum. art' the ]iromiiiiMit sym|ttoms ; occasionally pliMiritic pains arc present, or symptoms of liromdiitis, with ^reat dysjiiKea. When the nliilininiiiil riscrrn are affected, nausea or sickness and proru>e diarrhuu'a are j)rominent symptoms ; the latter in some cases apparently <-arries rjff the poison. When anvthiiiL; like sallowness of the skin or jaundice appears, liepatic; ahscess should he fjusjiectcd . and under tlu'se circumstances there will ; the one just mentioned — that it is only in exceptional cases of pysemia that any evidence can be found of phlebitis; and the sec- ond is almost equally strong, becatise, " so far from phlebitis being a cause of pya?mia. it is remarkable how often the former occurs without any contamination- of the blood what- ever — that is. if we can call that phlebitis where we find a vein and its branches quite closed by coagulum or adherent fibrin" (Wilks). Moreover, "it is a (juestion whether, in those cases in which the veins are plugged or inflamed, thrombosis and phlebitis are not the local and pyaemia the general eff'ect of the same cause '" (8avory) — that is, blood infection. With these views I cordially agree. That blood-poisoning may take place through veins is certain, although, as I have already shown, inflammation of their coats does not necessarily lead to it ; neither is it probable that the absorption of pus, as pus, is the usual cause, for. Avhen pus mixes with blood coagulation is produced, and thus its circulation is prevented. There seems, how- ever, good reason to believe that the fluid portion of pus or of some decomposing inflam- IWTIlOlJxncM. COM'lTloSX Fi:<)M I'V.KMfA inI'M) AFTKlt DKATII. 05 matnrv product iiiav lie takfti ii|> l»y tlic veins iiml rarriftl into the system, and thus fiiusi- |iv;i'iu:;t. The jmi.-nn niav l>o iuipnrted intn the <.'eneral cireuhition thri»uj:h either a sn)all nr hirL'e vein when involved in a supituratinfr or sh»u/' />f'tii(/-jtoisi>iiiii(/, as pyjcmia, are caused 1)V emholism. thromhosis. or hlood extravasation, due tr» the aihnixturc witli the Vdood of some morhid fluid ; and tliat this morhid material ori >li'f|i ami awakciiiriL'. will \n' ItatlK^d in jicrs|iiiaf ion. Wlu'ii tin- iliscast' is at its lu'ijxlit, the fold, IidI, and sweating; stap-s iiiav I"' casilv seen; but when it dfclincs, tlic fcUrilf syniptonis will ]n' cdnstant, altIioii<;li a}.';.'ruvat<'d toward iii^ht, while till' MiurniiiLr " <"ollii|iiativc' ' swi-ats grudually beconic more iirol'iisc as lite; ebbs away. In till' I'aily stau^-s of this disease, hrliDiu the paroxysms, there may be no fever. The tonjriu". dry durini^ the attaek, will }»e moist and elcan, l)Ut toward the close bt;eom(!S morbidly red, smooth, and son;, with ajdithous uleeration. The appetite an. Chirurgie (Lansjenbeck's), b. ii., vi., viii., ix. — Bristowk, Trans. Path. Sloe. Loud., vol. xiii., Reynold's System of Medicine. — Roser, Sydenhnni Soc. Year-Book, 1863, p. 192. — Prof. O. Weber, Berl. Klin. \Vochenerimeiits that the injection of twenty to thirty drops of a solution of one part of strong liquor ammonite to three parts by measure of water into one of the veins of the wounded limb, accompanied by the local application of li(|uor ammoni;\> to the part, is a specific ; but Fayrer, who has tried the practice, has failed to find the success looked for. Mitchell advises ligature of the cardiac side of the wound, or excision, amputation, or destruction by cautery or escharotics of the poisoned part, and even sucfion of the wound immediately after the bite, as the poison has no influence in the stomach. lie thinks well, also, of the injection into the wound of iodine or ammo- nia, and savs the natives believe the local application of olive oil to be the best. M. de Lacerda communicated in 1SS2 to the Paris Academy a note in which he asserts that a one-per-cent. filtered solution of the permanganate of potash injected beneath the skin or into the veins counteracts very eff'ectively the poison of snakes. "With this local treat- ment the patient is to be kept up by hope, the action of the heart sustained by stimulants quite irrespective of quantity, and the general powers maintained by nutritious food. By these means. '• if the person be not thoroughly poisoned, we may help him to recover. If he be badly bitten by one of the more deadly snakes, we can do no more " (Fayrer). Bites of Diseased Animals. Hydrophobia, meaning the '• dread of water " — which is more correctly termed "rahies' — is a disease contracted from the bite of a rabid animal through its saliva or mucus. It appears at all seasons of the j'ear, and is, as a rule, fatal. It is more common in temperate regions of the world than in the torrid and frigid zones. It is unknown in Australia, New Zealand. Greenland, and Kamschatka. Blaine and Youatt affirm that in animals rabies is entirely due to a trauTnatie action — viz.. the bite of some rabid creature inflicted on another previously free from the disease. Fleming, the most recent authority, tells us. however, that the virus of rabies may under certain favorable conditions be generated directly without the intervention of any infect- ing medium, although at present we are in complete ignorance of the conditions on which its spontaneous production depends. All animals bitten do not contract the disease, as is proved by Renault of Alfort. who cau.sed dogs, horses, etc., to be bitten several times, and even inoculated them, when, out of 99 cases. 67 contracted the malady, and 32, or one-third, escaped. Fleming calculates that 30 or 40 per cent, of people who are bitten by mad animals go mad. In the d"g there are three well-marked stages of the complaint. The prut is the mel- ancholic, characterized by melancholy, depression, sullenness. and fidgetiness; the second, the /itn'iiHS. by excitement or rabid fury ; and the A/s^ the paralytic, by general muscular debility and actual parah/aix. '• The dog.'' writes Trousseau. '■ looks ill and sullen after a period of incubation of a very variable length : he is constantly agitated, turning round and round inside his ken- nel, or roaming about if he is at large. His eyes, when turned on his master, have a strange look in them expressive of sadness as well as of distrust. His attitude is sus- picious and indicates that he is not well : by his wandering ' he seems to be seeking' for 104 BITES OF DISEASED AXLMALS. a remedy. He is not to be trusted : if he obeys at all. he does it slowly ; if you chastise him, he may in spite of himself inflict a fatal bite."' ''His agitation increases: if in a room, he runs about looking under the furniture, tearing the curtains and carpets, some- times flying at the walls, at others jumping as if to catch flies; the next moment he stops, stretches his neck, and seems to listen at a distant noise. He probably then has hallucinations of sight and hearing."' ■ This delirium.' says Youatt, •• may still be dispersed by the magical influence of his master's voice ; all these dreadful objects may vanish, and the creature creeps to his master with the expression of attachment peculiar to him. " " There follows then an interval of calm : he slowly closes his eyes, hangs down his head, his fore-legs seem to give way beneath him. and he looks on the point of dropping. Suddenly, however, he gets up again ; fresh phantoms rise before him ; he looks around him with a savage expression, and rushes against an enemy which only exists in his imagination. By this time the animals bark is hoarse and mufiled ; loud at first, it gradually fails in force and intensity and becomes weaker and weaker. In some cases the power of barking is completely lost ; the dog is dumb, and his tongue hangs out through his half-opened jaws, from which dribbles a fi'othy saliva. Sometimes his mouth is perfectly dry and he cannot swallow, although in the majority of cases he can still eat and drink. When he cannot drink, he will appear to lap fluids with great rapidity ; but on looking closely it will be seen that he merely bites the water. He can still, in some cases, swallow solids, and he may then swallow anything that is within hi.> reach — bits of wood, pieces of earth, straw, etc." '• Toward the close of the second .stage of rabid fury the dog often breaks his chain and runs away ; he wanders about the fields, being seized from time to time with paroxysms of fury, and then he stops, from fatigue, as it were, and remains hours in a somnolent state. He generally dies in a ditch or retired corner, apparentlv from hunger, thirst, and fatigue." Veterinary surgeons do not say that he dies from asphyxia brought on bj' spasm of the pectoral muscles or by convulsions. The disease runs its course in from five to eight days, and it is the same in the dog. cat. horse, and wolf, from any of which man may become inoculated. In man the disease may show itself at any period from six weeks to a year after the inoculation, although Fleming and Bouley assert that the incubatory period in man varies from one to two months, and that after the third month the chances of immunity are great. Thamhayn (Schmidt's Jahrhuch.. 1859). in an analysis of 220 cases, showed that in 49 the symptoms appeared within a month, in 98 during the second, in 29 during the third, and in 2G during the fourth, month. 16 of the remaining cases showing them- selves within twenty-six months, two cases only maturing at a period of four and five and a half years respectivel}'. But these cases are always doubtful, and are probably examples of hysterical or vervovs hi/dropliohia. Fleming,^ however, records some strik- ing cases which seem to show that the latent disease may be induced or brought into activity by mental agitation. The disease may attack the infant at the breast or the aged, the male or the female, and during the incubative stage no disturbance of the general health is usually observed. Van Swieten has pointed out that during this period such a disease as variola may run its course without any modification, two poisons thus coexisting in the same frame. After the incubative stage has passed the Jirst si/mptom usually displayed is that of sadness, the victim either not suspecting his complaint or carefully avoiding mentioning the circumstance. His sleep is disturbed : he is fidgety, sighs deeply, and avoids society ; he is troubled by noise or is very irritable and ill-tempered. The second stcK/e will be marked by an aggravation of all these symptoms, but there will be in addition pain in the region of the heart with some irregularity of the pulse ; rigors will soon appear, which, says Trousseau, •' are true convulsions of all the muscles of the body ;" and, lastly, the characteristic symptom of dread of water — not as fluid, however, but as connected with the diflicultv of drinking. The sight of water is frequenth- sufiicient to bring on shuddering, vet it is when the patient carries water to his lips that he is seized with the typical terrors. A rabid man is always rational and tries to drink, but the attempt excites terror and the expression of his inability. His eyes become fixed, his features contracted, and his countenance expressive of the deepest anxiety ; his limbs shake and the whole body shivers. The paroxysm lasts a few seconds, then subsides, but only to be renewed on the slightest breath of air touching his body ; for hi/persesthesia is one of the most marked symptoms of the aff"ection. ' Rabies and Hydrophobia, 1872. nrn:s of 1)Iskasi:i> AsnrALS. 105 Diiriiig tho faliii. nausea, or even vuniitinir. may appear, ami priapism is often a most distressiiifj symptom. Sudden terror of an unknown kind haunts the mind and iriiafrinary .•allinj; of fiends often e.\i.sts. Dr. Ber«rerons records a case in which the patient heard the iin<;in^' of bells and .saw mice run about over his bed. In the tliiril nmf /nsf sliujr the hin;rinjr tor drink becomes intense, with an increasing ina]>ilitv to take it ; the voice becomes hoarse and tlie mouth full of a frothy fluid. The patient tries to get rid of this by sjiitting. and then becomes frightened at its results. In some ca.ses he fears that by contact this fluid may pro|»agate the 'lise'ase. Convulsive seizures increase in fre(|uency and intensity, the spasm of the respirat(jry muscles threat- eniuL'^ life , at last a fatal spasm takes place, and death by asphyxia ensues. Cause of Death. — In the dog death results from jiaralysis ; in man it is due generallv to asplivxia, ami in exceptional cases to exhaustion. Duration of Disease. — This painful affection rarely lasts longer than four days, though it has been fatal in sixteen hours and has lasted as long as two or three weeks. Thamhayn shows that 5tj out of 20:^ cases died within forty-two hours, 73 in forty-eight hours, 88 between the second and third days, 19 between the third and fourth days, 7 in five. 5 in six, and 4 in seven days. The seat of wound or cicatrix rarely shows anything unusual. In three or four ca-ses out of a hundred it may be slightly painful, irritable, and inflamed, or the seat of a neuralgic pain, which in some instances is very severe and of the nature of '• aura," as in epilepsy. DiAGNOSi.s. — Taken as a whole, there is no disea.se like hydrophobia. In a certain sense it resembles tetanus, yet the two. in their general features, are unlike. They may, however, occur together, and so good an observer as Dr. J. W. Ogle has published a ca.se of combined tetanus and hydrophobia in the Briti.<}i and Foreign Medico- Chir. Reviev:. 1868. What Trousseau has called nervous hydrophobia — that is. true dy.sphagia brought on by a dread of rabies — may, however, be mistaken for it ; '• but the sudden invasion of this complaint, generally coming on through the person recalling to mind or hearing the relation of a case of true hydrophobia, and the duration of the dysphagia over the period of four days are amply sufficient to characterize the complaint and to enable the prac- titioner to persuade the patient that he is suff'ering from mere nervous .symptoms which will vani.-ih as soon as he ceases to fear. Besides, in nervous hydrophobia there is dys- phagia only, but no general convulsions, the spasm aff"ecting the pharynx alone, while the breathing goes on with regularity." In the very early period of the disease, during its incubation. Drs. Marochetti, Magistel. Xanthos. and others, have called attention to the presence of pustules or vesicles near the fra^num of the tongue, known in Greece as ^y.i:iis. 107 The I'HOiiNOSis of filaiiiliTs is most uiii;ivoral)lo, situ'O rocnvory only takos plafc in the mikU'st cases of poisoninj;. The disease in its aeutest H{ii3arents, the power of affecting the unborn foetus and the newly-born child. No other blood poison appears to possess this power — at any rate, to the same degree ; and it is 1 Vide Med.-Chir. Trans., vol. Ixv., 1882. sy nil LIS. ]()0 Well In hear tilis iiii|Hiii:iiit |i()iiit of (litrri'ciicf in iiiiiipcarancc oi" a s(»iucwliat irrc<:ular althouut not killed, and in the weakness of its possessor has reas.serted its power. No other animal poi.son a])])ears to have such tenacity of existence. Others produce tlieir specific effects in a definite way and in a regular series of symptoms and are either eliminated or destroy life ; they cease to act and become innocuous after having run their course, their power for harm being exhausted. The ])oison of syphilis, however, is so subtle that it is tolerably certain mo.st of the secretions of a sypliilitic subject are cap- able of producing the same disease in another, clinical experience having dis}»roved Hun- ter's opinion that syphilis could only be propagated })y the secretion of a primary .sore, and Kicords pro])ositioii that "chancre at the period of progress is the on/// source of the syphilitic virus.'" Indeed, it may fairly be asserted that a healthy woman, marrying a man who has had syphilis, but in whom all symptoms have long disappeared, may give birth prematurely to a dead f(ptus, to a stillborn child, or to an infant that will, cither at its birth or within a few weeks subsequently, show symptoms of syphilis, all the.se results being the effects of syphilis transferred from the father. On the other hand, no such result may ensue. Maternal heredity has a stronger influence than paternal. When both parents are syphilitic, the chances of a foetus being affected are grcatlv enhanced. '■ The semen of a diseased man depo.sited in the vagina of a healthy woman will, by being absorbed and without the intervention of pregnancy, contaminate that woman with the secondary (constitutional) form of the disease, and that without the presence of a chan- cre or any open sore cither on the man or the woman " (Dr. Porter, l)iib. Jourri. of Mefl. Science, 1857). A healthy woman nu^rrying a man Avho has had .syphilis, but who has lost all symp- toms of it, may — not must — acquire syphilis either through the medium of a blighted ovum or a series more or less prolonged of stillborn children, or through the medium of the utero-plaeental circulation. A healthy woman giving suck to -a child the subject of hereditary syphilis may acquire the disease through some fissure of the nipple, the di.sease locally and con- stitutionally manifesting its presence with all the intensity of a primary inocula- tion. Again, the secretion of any true syphilitic sore, chancre, or mucous tubercle, whether of the mouth, nose, anus, vulva, or penis, is capable of transferring the disease ; and the syphilitic poison may probably be simply absorbed by the vessels of a part { ph/jsviloqknl nhs^orptioii) without giving rise to any local aft'ection. Hunter believed this, and Lane, Marston. and Lee have published observations that tend to support the theory. " It should never be forgotten that it is the virus which infects the system, and that the sore is the mere local lesion, and not a neces.sary antecedent to infection " {Committee on Si/philis, p. 8). '• It is impossible to predicate with ab.solute certainty of any given sore that it will or will not be followed by con.stitutional infection " (J. Lane). It should never be forgotten that the poison of syphilis, however introduced into the system — whether inherited or acquired from primary sores or from the secretions of a syphilitic subject — is the same, and manifests its presence in much the same way. It may be difficult in individual cases to make out the direct source of the contagion ; but if we recognize the fact that the virus, however diluted in one subject, may, when introduced into another, behave as if it had been taken from a spreading primary chan- cre, the explanation of most clinical facts becomes easy. Syphilis is an animal and a human poison ; it is capable of propagation by any form of inoculation from the secretion of any syphilitic to a virgin subject in all its intensity ; it may likewise be inherited. Nothing is known of its nature, although its effects are sufficiently familiar 110 ACQUIRED SYPHILIS. How, then, it may be asked, is syphilis to be recognized? Is it to be recognized in its primary inoculation, or is it only to be known by its constitutional symptoms? It has been already stated that most authorities ai"e agreed upon the fact that there is no form of local sore or chancre that can be said with certainty to be the result of the local inoculation of syphilis. In the cartilaginous indurated sore with enlarged indurated glands there is every probability of syphilis manifesting its presence, and in the multiple, suppurating, non-indurated chancre there is every probability of no such symptoms appearing. But in the first form such svmptoms may not. and in the second they may, appear ; consequently, as a law this distinction becomes of little value. Indeed, syphilis as a disease can only be known by the manifestations of its consti- tutional symptoms, and not by the inoculation, in the same way as smallpox, when propagated by inoculation, is only to be recognized by the eruption, and not by the local appearances resulting from inoculation. Acquired Syphilis. Cause. — Acquired syphilis is contracted through inoculation from a chancre, from a syphilitic mucous tubercle, condyloma, or other syphilitic sore, or from the secretions of a syphilitic subject, the secretion of one form of syphilitic sore from one subject being capable of producing a chancre of another form in another subject. Drs. Maury and Dulles' have traced it to a '' tattooer " Avith mucous patches using his saliva to moisten the coloring-matter employed in his work. Mr. John Morgan of Dublin, by experiments, has been led to belie>e that ■• the dis- charge of a syphilitic female produces on !ence hy an eruption of macuUc, in another by a pa|)ular or sealy eru])tion, and in a third hy a j)ustular, tuhereular, or ulcerative form, is not known The theory propounded by Carmichael — that each sort of eruption has its own form of local sore or inoculation — was injrenious, but is not suj)ported by facts; and the generally-received o|iinioii is that the peculiarity or power of the infected patient has more to tlo with these phenomena than the nature of the jioison itself. The pustular anustule or of the vesicle, and at times the substance of the tuber- cle, break down ami L'ive rise to a troublesonui and spreading ulcer. Affections of the Mucous Membrane. — As the onttinh skin in syphilitic subjects is attaiki'd bv eruptions, sinipk- and ulcerative, .so the iiisldt skin or 7ni(co)is mem- hniiu's is etpially involved. " Every form of syphilitic affection of the skin," writes Lee, "has its counterpart in the mucous membrane; but the appearances will bo modified by the comparative thinness of the structure, by the absence of cuticle, and by the little dispo.sition these parts have to take on tlie adhesive inflammation." The mucous tuber- cle is the more common form, and is found in the organs of generation, tongue, mouth, lips, nose, palate, throat, rectum, and anus, and occasionally in other parts of the aliment- ary canal. It is known also in the laryn.x. At times these tubercles break down and ulcerate, giving rise to irregular excavated sores. Moist tubercles may appear in syphilitic subjects at any part of the body where two skin surfaces are in contact, associated with moisture. When they are found between the toes, they arc known as rfui'/nih's ; and when about the orifice of a mucous passage^ias a condyloma. Syphilitic sore throat may a])pear as a mere mucous patch upoh the surface of the mucous membrane, or at times as an ulceration of this patch, while at others it shows itself as a distinct affection, the throat becoming swollen and of a livid color and rapidly passing into ulceration. These ulcers may attack the soft palate, pillars of the fauces, tonsils, or pharynx, and present every kind of appearance, shape, and character. They may be serpiginous like the trail of a snake, horseshoe shaped or circular, superficial or excavated with sharp edges, inflamed, sloughing, or indolent. By themselves they are not typical of syphilis, however suspicious, and other concomitant symptoms are refjuired to determine the diagnosis. The mucous patch is the most characteristic. Xo ulceration is typical, although the sharply-cut excavated ulcer is the most unmistakable. In hered- itary syphilis this form of excavated ulcer is rare, though I have seen the perforating ulcer of the soft palate in an infected infant a month old. Syphilitic disease of the tongue is a very troublesome affection and manifests itself in a variety of ways ; it appears more commonly in the form of aphthous and mucous patches, ulcerating or otherwise, but not unfref|ucntly the whole thickness of the organ is infiltrated with the gummatous syphilitic material, either as an isolated nodule or as a general infiltration. When this nodule has softened down and suppurated, a deep excavated sore or fissure may be left, not unlike that of cancer; and when this sloughs or is of a chronic nature, the diagnosis becomes still more obscure. In cancer, however, there is probably a more marked local induration than in syphilis, and rarely a sharp, well-defined edge. The history of the case is, too, very different (n't/r Chapter XII.). The mucous lining of the mouth, lips, nose, etc., is also equally liable to syphilitic disease, either in the shape of aphthous and mucous patches or of ulceration not unlike that found on the throat or tongue ; indeed, the di.sease of one part of the mucous mem- brane is the same as that of others, the local appearances and symptoms being modified only by the peculiarities of the part. In ulceration of the rectum syphilis bears an important part, and as a cause of stric- ture it is not rare. When present, the disease usually spreads upward from the anus, the bowel being in .some cases superficially, in others deeply, infiltrated and ulcerated. This form of disease is more common in women than in men (virini:/) svrimjs. nr> also ill syphilis" (Mox«»n. Mr,/, '/'inns, .Iiuif -\. 1S71 j. In fjict, hcyond tho Ii»cal inoc- ulation, syphilis fixi-s upon, or rather attacks, an orjran much as any other disease, pos- sossiiii; no lipeeial jiredileetion for one or^'aii or tissue; in preferenee to another, the so- called secondary and tirliary afrcctions havinL' no real dinen-ricc save ordy in the surgeon's mind. 'rKKATMKNT. — There is no remedy in the i'harmacopu'ia that can he relied upon as a specific tor syphilis, althoUL'h there are many that have a very Itenefieial iiiHuence in aid- ing the disappearance of the symptoms; they can, however, do no more. It is, indeed, a (juestion whether the disease is really ever cured — whether a person once under the influ- ence of syphilis is not really like one hroujrht under the influem;e of vaccinia; which means that his hody has heeii so affected hy the poison as to he influenced by it for life. After successful vaccination a .^second inoculation rarely takes as it does in a virgin sub- ject, and after true syphilis a second attack rarely if ever ensues, Porter's law being tolerably proved — " that the influence of syphilis never returns upon itself or recontam- inates the source from which it had been derived" (JJuhfin Quart., 1857). Ilicord, Lee, and others have proved that the .soft or non-infecting chancre is the oidy one that can be inoculated with success on the same subject. It is true that in a large number of cases syphilis appears to be cured, that the symptoms disapjiear, and that the health of the patient is re-established ; yet it is ecjually true that in such ca.ses, after the lapse of years — it may be, even after a (|uartcr of a century — the existence of former syphilis is 'again recognized if the health of the patient is lowered. So long as the powers of the subject who had syphilis remain good, no evidence existed of its presence ; but when these failed, the ]toison reasserted its claim to recognition. It must, however, be stated with consid- erable confidence that nature, unassisted by art, seems incapable of eliminating the dis- ease or of arresting its progress. On Uif skin eruption, sore throat, or other affection of the mucous membrane of the intestinal or respiratory tract, mercury is beneficial. The best mode of using it is generally sup- posed to be by inunction — /. e., the rubbing of mercurial ointment about the size of a nut, or, what is better, of the oleate of mercury, ten-per-cent. strength, the size of a pea, into the axilla twice a day till the gums are touched, and after then only once a day. Dr. B. G. Babington recommended the inunction in adults to the soles of the feet, the rubbing in being performed by the action of walking. The internal administration in bark of the bichloride of mercury in doses of one-sixteenth of a grain three times a day is a good form of administration, as is also the green iodide of mercury in grain doses twice a day, with Dover's pill. Some surgeons still use the blue pill with opium. During the last eight or ten years I have been using the mercurial suppository twice a day, and have been greatly satisfied with its action ; the drug acts as well thus as by the mouth and in no way interferes with digestion or the functions of the abdominal viscera. Indeed. I am disposed to think it by far the best mode of administering mercury ; I know of no objection to its use. Next to this plan, the calomel vapor bath is the best. The most convenient calomel vapor bath, writes Lee,' is one which was made at my request by Mr. Blai-se. In this apparatus the lamp which sublimes the calomel boils the water at the .same time. In the centre of the top, immediately over the wick of the lamp, is a small separate circular tin plate, on which the calomel is placed ; around this is a circular depression, which may be filled one-third with boiling water, the apparatus being placed on the ground and the lamp lighted. The patient then sits over it with an American cloth cloak or mackinto.^h fastened round his neck. He thus becomes sur- rounded with calomel vapor, which he is generally directed to inhale for two or three separate minutes during each bath. In doing this the patient should not put his head under the cloak, but simply allow some of the vapor to escape from the upper part and breathe it mixed with a large proportion of common air. At the expiration of a quarter ' Holmes's Surgery, third edition, vol. iii. 114 ACQUIRED SYPHILIS. of an hour or twenty minutes the calomel is volatilized and the water will have boiled away, a portion of the calomel being deposited on the patient's body. The patient may then gradually unfasten his dress and put on his nightgown, but must not wJ[)e his skin. If he prefers it, he may go to bed in the cloak and wear it. The bath ought to be used every night, and five or ten grains of calomel is the quantity that should be evaporated. Bricheteau, Lewin, and Sigmond have employed the hypodermic injection of mercury with some success, throwing in fifteen minims of a solution of corrosive sublimate, four grains to the ounce of water. Iodide of Fofaamnn. — For feeble cachectic subjects, however, mercury is ill adapted, and for such the iodide of potassiiim in five-grain doses, gradually raised to ten, or more, will do all that is needful. In London practice it is generally required to be combined with some tonic, such as bark, quinine, or iodide of iron. The combined use of mercury and i(jdide of potassium will occasionally be of great value. When the mucous tracts are involved, the addition of some alkali, such as the bicar- bonate of potash, in ten-grain doses, to the iodide is advisable. The addition of the compound spirit of ammonia to the bark mixture is also useful. When the symptoms begin to yield, the ti'eatment must be continued ; inc^eed, the effects of the drugs, whatever they may be, should be kept up for at least six months after the disappearance of all symptoms, otherwise a relapse will ensue. Comparison of Mercury and Iodide. — Comparing the effects of the two drugs together, it may be asserted that the mercurial plan of treatment is more applicable to the early than the late symptoms of syphilis ; that in cases of relapses or of late syphilis the iodide of potassium is preferable, although under both circumstances, in exceptional cases, one plan of treatment will succeed whei'e another fails. When iodide of potassium cannot be tolerated, iodide of sodium may be substituted. Ij!('f, — During the course of syjihilis the patient should live on simple, nutritious, but non-stimulating, diet. Wine and beer should be given in moderate proportions, spirits never allowed, and smoking, as a rule, should be interdicted. When mercury is being employed, the skin should be kept warm and the feet dry, all sudden chills being bad. When suppuraticm or ulceration exists in any form of syphilis, mercury is rarely applicable ; iodide of potas.sium combined with tonics is then the best drug, with or without opium. Sarsaparilla has no specific influence in syphilis ; it is a pleasant vehicle, but nothing more. Opium combined with other drugs is at times of great value ; with mercury it is invaluable. It may be given in small doses whenever the nervous .system has been overwrought and there is great irritability of pulse. The syphilitic affections of the mouth, tonsils, throat, tongue, etc., are expedited in their disappearance by the local apjilicatiou (if nitrate of silver, chromic acid, gr. v to x to the ounce, chlorate of potash, boracic acid, or borax gargle ; constitu- tional treatment should be simultaneously employed. The mucous tubercles of the genitals and other parts are most successfully treated by the local application of calomel, which should be dusted over the diseased surfaces through a muslin bag. A good rub with nitrate of silver at times expedites the cure. The parts should be kept well dry. Condylomata are not so amenable to the calomel treatment as the moist tubercles; they may, however, be successfully treated by the local application of the chromic-acid solution, nitrate of .silver, or sulphate of copper, by a lotion of bichloride of mercury gr. ij to the ounce of water, or of black wash. When the growths are very fle-shy, excision is the best practice. In ulceration of the throat iodide of potassium, in doses varying from six to fifteen grains three times a day. is of great value, with the local application of the nitrate of silver in stick or strong solution ; a gargle of alum, chlorate of potash, or borax, a drachm to a pint of water, is also good. In laryngeal disease the iodide must also be given quite as freely ; and when ulceration has commenced and seems to be unaffected by general treatment, tracheotomy claims serious consideration, because, unless the larynx can be kept quiet, repair will not ■go on, and so long as ulcerative disease is present a sudden spasm of the glottis may occur and render imminent the death of the patient. The operation should, however, only be undertaken when the disease is steadily progressing in spite of treatment, and if it is clear that the larynx will be destroyed as a vocal as well as a respiratory organ unless some steps be taken to stop its progress. Of these steps there are none equal to trache- otomy, for all surgeons are familiar with the fact that even under the most extreme con- ditions of disease repair goes on in the larynx directly the tracheal tube has been intro- HEREDirMlY SYPHILIS. 115 duced, and physiological rest is given ton. however, to ht-iieve that in the vis- ceral as well as in other diseases which may he looked upon as the se«|ueUe of syphilis, or as the result of the cachexia caused by the disease and the remedies emph^yed fur its reniiival. ioilidf of jtotassium alone has little influence. J>r. Wilks has shown how the lardaceous and wa.xy diseases of organs are found after .syphilis, and every one knows how little amenable to treatment these affections are. Dr. Dickinson has. however, done some- thing to prove that they are due to a want of alkalinity in the blood, and are to be pre- vented, and in a manner cured, by the medical use of alkalies. With the same view a non-nitrogeni>us diet should be allowed. During the later period of the disease, when the gummous depositions take place, whether it be visceral, osseous, glandular, or otherwise, iodide of pota-ssium in full doses is of great value. In the sequelje, in waxy or lardaceous disea.se. it is of little u.se. alka- lies with tonics being then apparently the best. Upon this knowledge it is probable that the late Mr. Aston Key based his advocacy of lime water and the infusion of sarsaparilla in the syphilitic cachexia. Hereditary Syphilis. That syphilis is capable of being propagated by hereditary transmission is a clinical fact generally recognized, constituting the main distinction between syphilis and all other animal poisons. To what an extent this influence spreads is still a debatable question. According to some observers, instead of diminishing, the radius of its action appears to be yearly increasing. That the child of a parent who has had syphilis moT/ — not /»?/.«/ — inherit the disease is generally acknowledged, and when both parents have been affeetefj the probabilities of its transmi.ssion are. doubtless, increased ; but data are still wanting to determine under what circumstances the offspring of such parent or parents is likely to be born healthy. There is, however, some reason to believe that when the mother is at fault the early conceptions are more likely to be blighted and the later come to maturity ; whilst when the father is at fault the first conceptions .show few. if any. signs of the affection, the symptoms becoming more marked in each succeeding one, till at last the ovum becomes blighted and the wife constitutionally affected. The probabilities of the child being affected, as well as the degree of the affection, turn, likewise, much upon the period of time which has elapsed between the disappear- ance of the con.stitutional symptoms in the parent and the date of marriage. Daily experience proves, however, that a man who has had syphilis and lost all traces of it under treatment, who enjoys good health and marries a healthy wife, maybe blessed with healthy children in whom no traces of .syphilis can be found : but the .same experi- ence also indicates that these subjects, marrying in a less vigorous condition or lapsing into bad health, may give rise to diseased offspring. A certain number of children succumb in their mother's womb to syphilis solely because they are already affected with the disease. At other times the children come into the world with lesions unmistakably .syphilitic : while in the great majority of cases the child who inherits .syphilis has at first the appearance of health and some weeks after birth presents signs which betray the evil transmitted to it from its parents, it being usu- ally from the first to the third month of extra-uterine life that .syphilis manifests itself in the new-born child. Cullerier cives a vear as the latest time for the disease to show itself. With respect to the symptoms of hereditary .syphilis, it may be well to a.ssert at the beginning that, with the exception of the primary inoculation, they are much the same as those of the acquired disease. Affections of the skin are found a-s-sociated with those of the mucous memVjranes, bones, or viscera, and these manifest themselves in no definite order. At birth the child may be plump and fat. and for some days appear healthy in every respect. After the lapse of a few days some difficulty in breathina will probably appear, with symptoms of cold in the head, these so-called " snvjffes '" being always suspicious. At this time, if the skm be carefully examined, more particularly about the buttocks and feet, some eruption will be seen. This may be simply a staining of the skin or a more definite papular, vesicular, or pustular rash : it may be associated with some affection of 116 HEREDITARY SYPHILIS. Fig. 23. the internal skin or mucous nK'nil)raiie, mucous patches or condylomata showing them- selves at the anus, about the mouth or within it, around the nose or other parts. The seat of the eruption is greatly determined by the degree of cleanliness observed, the irri- tation of dirt and moisture in any locality in syphilitic children being followed by condy- lomata or mucous patches. The orifices of the nose, mouth, and anus are at times fissured in a very marked man- ner, and occasionally leave traces of the disease which can never be mistaken even years afterward. In the annexed drawing these alterations about the face are most typically shown (Fig. 23). When the disease is allowed to run its course, the child's general condition suffers; it becomes emaciated and puny, the digestive organs become deranged and refuse to assimilate food, however good, while vomiting and diarrhcea are common consequences. Evidence of starvation soon appears ; the skin becomes baggy and of a peculiar dusky hue; when not covered or scarred with eruptions, it may have a jaundiced appearance; and the child will pr(»})ably die from what is called marasmus, which means wasting from starvation. When the disease does not run so rapid a course, other symptoms show themselves. It may be in the skin, bones, eye, ear, or viscera. In the akin, subcutaneous or submucous tissues the disease may appear in the form of ijummi/ swclfi)if^.s or tumors, which may break up and give rise to irregular excavated cellulo-membranous abscesses. In the bonrs the disease may show itself as nodes, the humerus appearing to be the bone most commonly affected, though I have seen several instances in which the bones of ■ the .skull were frightfully involved. In the eye the symptoms are well known ; interstitial keratitis, a form of disease, according to Hutchinson, which is peculiar to hereditary syphilis, generally shows itself between the ages of eight and fifteen years. It appears as a iliflf'used haziness of the centre of the cornea, unattended with ulceration ; this haziness begins in independent patches, which subse((uently coalesce, the cornea at a later date appearing like ground glass. The affection is attended with photophobic pain about the orbit and the sclerotic injection. It generally involves both eyes seriatim. Under treatment the disease may be arrested ; but when it is severe, patches of haziness renuiin which interfere with vision and at times cause complete blindness (Fig. 23). Iritis is another complication, though a rare one. as is choroiditis, and also amaurosis. Deafness is not unfrequent. the hearing failing without any external disease, such as otorrhoea. In most cases both ears are affected. Hydroceplialus and syphilis are also allied. Sj/philitic disease of the testicles is also to be met with. I have seen several cases of this nature, and the most marked was in a boy four months old, the third child of syphilitic parents, who had snuffles and mucous patches on the lips. I]ach of the testicles was an inch and a half long and very hard. The disease was cured by mercurial treatment. There is reason to believe, moreover, that in hereditary as in acquired syphilis every organ of the body, in different cases, may be found diseased, the viscera of the cranium, thorax, and abdomen, with the glands generally, as well as the skin, mucous membrane, mu.scles, nerves, and bones. It is difficult to decide how far the syphilitic poison follows the subjects who inherit it. It is no uncommon event to find a child entirely free from all evidence of constitu- tional syphilis born of parents who had previously given, and may subsequently give, birth to stillborn or diseased offspring. A healthy child may stand alone in a long series of conceptions as a living proof of the power of life even over such a poison as syphilis. I have also before me the notes of an instance of twins born of syphilitic parents ; one passed through all the series of complaints common to hereditary syphilis, while the other escaped altogether — that is, at the end of a year and a half no symptoms had appeared. I have the notes of another case of twins, born under like circumstances, in which the symptoms appeared in one at the end of a month, and in the other in the fourth month. Such cases as these would appear to show that the manifestation or non-manifestation Hereditary Syphilis. {Frmu life.) iii:i:i:i)irMiY syriiius. 117 Fig. 25. ^^^y Syphilitic Teeth. llealthv Teeth. (it" till- .syiii|itniiis ul' licrnlilary .syi>liili.s (Ii'|m-ih1.^ inurh ii|>(iri tin' |)cr.s(iii;il power nl" the cliilil who iiilicrit.s it, :i strong cliild throwiiiix oil' or fliiiiiniitiiitr tln' poLsoii. wliilc tin; WL-ak falls uiaK-r its iiiHiifiicc. .sine*' in tlio case; of" the twiii.s altovt- iiii'iilioiird tiiere can he no niicstioti as to the simiiaril y of" tin- foiidilions uinh-r which llicy wurc |ilacLMl. In hcn-ditary sv|iliilis this conclusion is fomnlcd u)ion slroni; cvidcnct;, ami in the acijuin^d it is at least prohahlc. Affections of the Teeth. — .Vmonirst tin; evidences of" li(;reditary syphilis estalt- lislicil l>y .Mr. 1 1 iiicliinsori tlitic are often pr(;sent in the permanent teeth iinportatit indi- cations — .so important, indeed, that when jiresent the existence of hereditary syphilis nniy with .some confidence he pronounce*]. They, however, exist oidy in exceptional instances of hereditary syphilis. '' The centnil iijtjtir incisorn of the, mrond xrt arc the tpM teeth;" these are usually short and narrow, with a hroad vertical notch in the edges, and their corners rounded of}' (Fifr. 24). Horizontal notches have nothinii; to do with syjihilis. " Next in value to the malformation of the teeth," writes Hutchinson, ''are the state of the patients skin, the formation of hi.s nose, and the contour of his forehead ; the skin is ahmjst always tliick, pasty, and opa(iue. It also shows little pits and .scars, the relics of a t'ormer erujition, and at the angles of tlie mouth are radiating linear scars running out into the elieeks. The bridge of the nose is almost always hroader than usual, and low ; often it i.s remarkahly sunk and expanded. The forehead is u.sually large and protuberant in the regions of the frontal emi- nences ; often there is a well-marked broad depression a little above the eyebrows. The hair is usually dry and thin, and now and then the nails are broken and splitting into layers. Interstitial keratitis is pathognomonic of inherited taint; and when coincident with the syphilitic type of the teeth, the diagnosis is beyond a doubt." In Fig. 2o every point in this description is illustrated except with reference to the teeth, which were unusually good. There is, however, good reason to believe that the children of .syphilitic parents mm/ be affected by the poison in a way wdiich cannot be classed amongst any of the ordinary forms of hereditary .syphilis as described. Treat:vient. — To help the disappearance of the symptoms of hereditary syphilis remedies are of great value, and in an infant showing evidence of any constitutional power the prospects of a recovery are very good. When the child is being suckled, whether the mother shows or not, I have for many years administered my remedies through the mother, giving her from six to ten or sixteen grains of iodide of potassium with quinine, or other tonic mixture, three times a day, half an hour before the child is put to the breast ; and I have been much impressed with the excellent results of the practice. When this process acts slowly, I give the child in addition a grain of gray powder, with three or four grains of dried soda every night. Before this I administered the gray powder and soda twice a day. or rubbed in about ten grains of blue ointment every night on the soles of the child's feet, the abdomen, or the axilla, but I much prefer the practice previously laid down. In young infants the mercurial ointment may be put on the belly-band and thus rubbed in. As the snuffles disappear the eruption and mucous tubercles fade, and the child begins to fatten and show signs of progress. The treatment should be kept up for at least a month after the disap- pearance of all sympt(jms. The chlorate-of-potash treatment in some instances is doubtless attended with no unfavorable result, strong infants with care and nursing battling through the disease, and possibly eliminating it. But the weaker die when through more active measures they might probably have been saved. Many apparently hopeless victims of hereditary syphilis become under treatment .strong and healthy infants. A child with hereditary syphilis should under no circumstances be suckled by any other than the mother, for many a healthy wet-nurse has been inoculated by such a crim- inal practice. When the mother cannot attend to the child, it should be brought up by hand. Serpiginous Ulceration. This is a rare and somewhat singular form of venereal disease. It would seem to be more closely connected with the local suppurating non syphilitic sore than the syphilitic, 118 SERPIGINOUS ULCERATION. for it is rarely if ever associated with constitutional syphilis. It usually appears in the groin or thigh after a suppurating bubo the result of a suppurating non-syphilitic chancre, the opening in the groin spreading in crcscentic patches of ulceration, one part of the sore increasing while a second is healing; when the cicatrix forms, it presents a smooth glazed appearance. This ulceration is most obstinate ; indeed, medicine appears to have little or no influence on its progress, and it may so spread as to extend over the thighs and lower part of the abdomen and continue at intervals for years, but wearing itself out at last. I have seen one case in which it spread as high as the umbilicus and as low as the knee. The disease at one time promises to heal, and then spreads without any clear cau.se. It is often found, too. in apparently healthy subjects, and appears to follow some course of its own that is not yet understood. It should be added that this sore is capable of being inoculated u{i()n the .same subject, the point of inoculation taking on the same action. Treatment. — Mercury and iodide of potassium appear to have little or no influence on this malady ; and if the view indicated by its cour.se be correct — that the disease is not syphilitic — such a result is only what should be expected. The local treatment of the sore seems to be the most important, and the best practice con.sists in the local applica- tion of some strong caustic, such as nitric acid, carbolic acid, or the cautery, either gal- vanic or actual, the patient being under the influence of .some anaesthetic. The local application of iodoform or of resorcine in solution fifteen grains to the ounce of distilled water should also be tried. Opium in moderate doses is of use, and so also are tonics ; but in a general way the subjects of this affection are in good health. In several instances I have found a sea-voyage of more value than any other treatment. In three cases the .sore rapidly healed after the operation of .skin-grafting had been performed. When maij a man icho has had syphilid marry? is a question which is often asked; and to answer it with any degree of confidence is no easy task, assuming, as I do, that the opinions laid down in these pages are correct — that a man who has once had syphilis can never be pronounced free from its influence, and that the poison, once in the body, may reveal its presence a quarter of a century after all external evidence of its existence in the form of local di.sease has disappeared. A man who has had .syphilis may, therefore, when he marries so aff"ect the ovum of his wife as to cause its death or produce some evidence of disease or feebleness ; or if the wife be healthy and he himself in good condition and free from evidence of the disease at the time of conception, the offspring may escape altogether and appear as healthy as that of other uninfected parents. Indeed, it would appear that if a man marries when in robust or good health a year after all evidence of the disease has vanished, he may be the father of a healthy child ; but if his general condition fails and he becomes cachectic, the poison may reassert its influence and manifest its presence by some feeble, or even disea.sed. condition of the subsequent offspring. When the mother is affected with the disease, the same risks are run. Every parent who has had syphilis runs the risk of giving birth to feeble or diseased off"spring ; these risks are diminished by the general vigor of the parents, and increased by dimini.shed power. No man should marry so long as the .slightest taint of the disease manifests its presence ; but if in good health and free from all evidence of its presence for a year, marriage may be contracted. To ask for a longer delay when such a step is contemplated is unfair and unnecessary ; a risk must be run, and the lapse of a longer period will not lessen it. Inoculation and Syphilization. Ricord was the first surgeon who employed inoculation f(ir diagnostic purposes in venereal affections, and through his experiments he was led to the conclusion that " a chancre at the period of progress is the only source of the syphilitic virus." As a test of the simple suppurating sore it may now be employed, for a second sore can readily be obtained by inoculating a patient from the pus of his own primary one. Indeed, this process of auto-inoculation may be continued for a long series, but only with any effect from the suppurating sore. In the .syphilitic sore no inoculation will take, and in the inoculation of common pus no reaction occurs, or next to none, a simple pustule probablv alone appearing. From these clinical facts it would appear that common pus, the pus from a suppurat- ing non-syphilitic sore, and that from a syphilitic one are very distinct, including under the term '• .syphilitic "' any sore that is followed by .syphilis. VAccfxo-svi'nfijs. 119 Hv iiinculaiiitii. tlicrcturi', :i siiru'i'iiii may fairly (Irtrriiiiiie tlic fact as to tlic nature of u chancre, and under Minie cirennistances tlie evidence <)l)lained \i\ tlie practice mav be valnalde. Syphilization nri<:iiiated in 1st J throii^di sunie exjierinients of M. Auzias Turenne U|>iin aninial> In iunciilate them with syphilis, and in these lu; i'ound that after a number of inoeuhitions they Iteeame ])ratient has recovered bis health." Boeck never iMMctised syphilization until the constitutional symptoms appeared; for, says he, " I cannot double a malady already j)resent, so I am f|uite certain not to do harm to the patient." Syphilization is not used with e((inil success aL-^aitist all cases of syphilis. " In those that have not been treateil with mercury the ]irnject mav l>e ascertained. Instructions for Vaccinators. — Vaccinate only subjects who are in good health. Ascertain that there is not any febrile state, nor any irritation of the bowels, nor any unhealthy state of the skin, especially no chafing or eczema behind the ears or in the groin or ehsewhere in folds of skin. Do not vaccinate in cases where there has been recent exposure to the infection of measles or scarlatina, nor where erysipelas is prevailing. Lymph is to be used according to the following instructions : 1. In proceeding to use a charged capillary tube, snip off its two ends; then from one end of the tube blow the lymph through the opposite end upon the arm of one of the infiints, over the place where the operation is to be performed, having had previou.sly two or three other infants' arms prepared for vaccination. The lancet is then to be loaded from the drop and inserted into the arms of the children prepared to receive it. but enough is to be left upon the original arm to vaccinate that child. L^nless the tube be very copiously charged, not more than two children are to be vaccinated from it. The insertion should ])e made in four spots, as hereinafter directed. 2. In operating with a charged ivory point use no wafer to so/ten the li/mph. In this 120 TUMORS. mode of vaccinating the operator shouUl make a few scratches just fhrovgh the cuticle, only sufficiently deep to tlomp the surface with hJood. These scratches should he mode ■in four qjots. each covering a surface, at nearly one inch apart. The scratches may be abrasions of the cuticle by fine parallel lines or by further cross-.scratch. The operation may be performed on both arms when the surface available or the po.sition usually selected is of limited extent. The operator should proceed with caution and take time. On no account should incisions be made and the point of the ivory inserted into them, and it should be borne in mind that the vaccine virus ought not to reach the subcutaneous cel- lular tissue. The child should be kept under observation till the spots are perfectly dry, and orders Lnven that the arms mmt not he v:ashed. 'i. Selection of Lymph. — Never either use or furnish lymph which has in it any, even the slightest, admixture of blood. In storing lymph be careful to keep separate the charges obtained from different subjects, and to affix to each set of charges the name, or the number in your register, of the subject from whom the lymph was derived. 4. Never take lymph from cases of revaccination. Take lymph only from subjects who are in good health and. as far as you can ascertain, of healthy parentage, preferring children whose families are known to you and who have elder brothers or sisters of undoubted healthiness. Always carefully examine the subject as to any existing skin disease, and especially as to any signs of hereditary syphilis. Take lymph only from well-characterized, uninjured vesicles. Take it (as may be done in allregular ca.ses on the day week after vaccination) at the stage when the vesicles are fully formed and plump, but when there is no perceptible commencement of areola. Open the vesicles with scrupulous care, to avoid drawing blood. Take no lymph which as it issues from the ve-sicle is not perfectly clear and tran.sparent or is at all thin or watery. Do not, under ordinary circumstances, take more lymph from a vesicle than will suffice for the immediate vaccination of five subjects, or for the charging of seven ivory points, or for the filling of three capillary tubes ; and from larger or smaller vesicles take only in like proportion to their size. Never squeeze or drain any vesicle. Be careful never to tran.s- fer blood from the subject you vaccinate to the subject from whom you take lymph. 5. Keep in good condition the lancets or other instruments which you use for vacci- nating, and do not u.se them for other surgical operations. When you vaccinate, have water and a napkin at your side, with which invariably cleanse your instrument after one operation before proceeding to another. With these precautions vaccination may be regarded as a perfectly safe operation ; without them the risks of syphilitic inoculation, although slight, exist.' They tell, how- ever, but little against the enormous advantages of vaccination. Lee, Holmeii's System, third edition, vol. ili.— Marston, Med-Chir. Trans:., vols. xlv.. xlvi. — Laxc AND Gascoyex, Med.-Chir. Tram., vol. 1.— Bf-MSTEAD, Edit, of ddlerier, Pliiladelphia. 1868.— Por- ter, Dublin Quart., 1857. — Lanx-ereaux, Oji Syphilid, Xew Svd. Soc. — Wallace, On Venereal. — Carmichael. On Venereal. — HuTcmxsox, Syphilitic Dliea.^es aj Eye and Teeth. — Report of Committee an Venereal Diseases, 1868.— TuREXKE, Academie des Sciences, 1850.— Boeck, Edin. Med. Jour., lSo8.— Dublin Journal, 1857. CHAPTER III. TUMORS. I.\ the prepathological period, before the minute anatomy of healthy and diseased tissues was understood and the microscope had rendered intelligible subjects that still rested in darkness, tumor.^ had from neces.sity been .studied simply in their clinical aspects, and surgeons, in their attempts to classify them, were guided .solely by the mo.st obvious characteristics of the growths and by their real or fancied resemblance to the natural tissues of the body. As time advanced more ambitious attempts at classification were made, and the most important work was that of Ahernethy. who at the beginning of this century puVjlished his Atttnipt to form a Classification of Tumors according to their Ana- tomical Structures. In that able production he asserted " that the structure of a tumor is sometimes like that of the part near which it grows, and sometimes unlike ; that in many cases the nature of the tumor depends on its own action and organization and merely receives nourishment from the surrounding parts.'" He thus gave expression to patlii)loj^ic!il tnitlis r)f tlio re similar in structure to the natural eonstitucMits of the body, and tho.so /ted roj)/iisfic which were composed id" products whi(di ilifler frr)m the normal tissues. Since that time countless workers havt; becMi examining tumors and attem|itinii- to classify them, one of the most prominent bein<^ Lebert, and to him must fairly l>e attributetl the credit of assij;iiin^ specific elements to specific tumors, eacdi tumor havinir, in his opinion, a definite structure ; cancer was to be known by the caudate fusi- form cells that even now are looked upon by s(uno as typical of the di.sease. This notion of specific elements was very feasible. f(jr it simplified knowled/s a part of the hod !i from idilch it spriinj^, and that it is not develoj)ed in an isolated manner at the expense of some juice, at some one place in the body, by the inherent force of this pro- ductive juice. To admit such a mode of development dc voro was possible at a time when it was also believed that entozoa were spontaneously developed in the body at the expense of a liquid or an excretion, by equivocal generation, when no idea had been as yet formed as to how a cy.sticercus arrived in the abdomen and there was able to develop itself and grow. There was no other opinion which medical men could then form save that entozoa sprung from aninuil substances, either from the tissues themselves or from the intestinal mucus (^mbxrnt). In the present day, when it is known that entozoa always penetrate into the body from without — by a way often, it is true, extraordinary, yet always natural — this analogy can no longer be invoked. This is still more evident since we have come to know that in a free exudation there is no new element produced — that, furthermore, the elements of the body itself have a legitimate origin from father and mother (or, to speak more correctly, from father or from n)other, for it is a case of parthenogenesis) ; so that we must completely abandon the idea that a tumor can develop itself in the body as an independent being. It is a part of the bodij ; it is not merely contiguous to it, but proceeds from it and is subject to its laws. The laws of the body govern also the tumor. This is the reason why it is not an object of natural history that one can regard as foreign from the elements of the body ; it is, on the contrary, to be looked upon as embraced within its limits Hair may make its appearance and grow at a place where we do not expect to meet with hair, but no one will fancy or believe that feathers will grow in the human body. As a matter of fact, there are tumors in man which contain hair, and in cutting up geese tumors are sometimes found containing feathers ; but if ever a man engendered a tumor with feathers or a g(jose one with hair, this would be a production sui. generis^ because the thing produced would devi- ate from the type inherent to the individual. " The type which in (je)iir(d i/overns the devlopnirnt and formation of the organism gov- erns equally the development and formation of its tumors. " There does not exist a new, different, independent type. " What is established by logic in this matter results also from the direct observations of tumors themselves. This is why I deny that there is any heterology in the sen.se in which it has been maintained since Bichat's time, or such as was suppo.sed even before then — that is to say, that a tumor could develop it.self and exist in the body in accord- ance with some quite new plan, some new law. I go farther: each .species of tumor, whatever it may be, answers in its important parts to the elements of the body the type of which is known, and the capital difference amongst divers tumors resides in this — that tissues normal in themselves appear under tlie form of a tumor, sometimes in regions 122 TUMORS. where this tissue normally exists, sometimes in places where it does not exist in the normal state of things. In the first case I speak of it as homology ; in the second, as hetfroloiiij. '' Wherever a normal tissue appears at a point which already contains some similar tissue, then as a consecfuence the new tissue is identical with the old. so that the type of the new production answers to the type of the pre-existing tissue ; in this case the new tissue, the tumor, is homologous. When, on the contrary, the new type does not corre- spond with the old one, when it deviates from the pre-existing type or that which is the original and normal one of the region, then there is heterology. But this latter has like- wise its analogue in the body, only in another part of the body from that in which the tumor is situated. "We cannot, in my opinion, distinguish tumors according to the tissues in such a fashion that tumors containing certain tissues are to be regarded as homoeoplastic, whilst those containing certain others are to be set down as heteroplastic ; cjuite the contrary, the same kuid of tumor may he, under certain circumstances, Jiomologons, and under other circumstances heterohgous^. The same sort of tumor may at one time appear at a point where it is merely the expression of an excessive development of the tissue normally exi.sting at this point, at another time at a place where this tissue is not in existence and where its development is abnormal and strictly pathological Let us take an example. A tumor may be formed of cartilage. The cartilaginous tumor is homologous, not because it is formed of cartilage, but only if it springs from cartilage, if in this place there is cartilage already. Thus, a costal cartilage may be the point of origin of an enormous cartilaginous tumor ; this is homology. But it is also possible for a cartilagi- nous tumor to be developed in the testis, which contains no cartilage, where this tissue should not be met with : here the same product constitutes an heterology." " Homology " and " heterology " have, therefore, very different meanings as used by Yirchow and other writers. In Virchow's language a tumor is hornologous when it cor- responds in structure with the tissue in v:hich it grows, and heterologous when it deviates from that structure. A tumor that is homologous in one position may be heterologous in another. On the other hand, in the French and other schools a tumor is homeAogous when built up of elements naturally existing in some tissue of the body, heterrjlogous when composed of elements that deviate from the natural structures, these definitions having nothing whatever to do with the position of the tumor. In Virchow's language the terms are relative ; in that of other pathologists they have a definite clinical meaning of no slight importance, for homology means innocence and heterology malignancy in a tumor. Yirchow, however, admits that his heterologous tumors are suspicious, although every heterologous tumor is not of a malignant nature. " There are a great many such tumors borne without any ill consecjuences, and whose properties are quite similar to those of which the nature is benign. Malignancy follows a certain scale among heterol- ogous tumors, from species to species ; and we are able to show how it is manifested more and more strongly, for the most part following two directions. In the first place, heterology is distinguished according to the degree which it attains. The tissues of con- nective substance have a much nearer relationship existing among themselves than they have with epithelial tissues or with the specific animal tis.sues. When, therefore, a car- tilaginous or bony tumor is developed in connective tissue, or even a mucous tumor in adipose tissue, that is not nearly so heterologous as when an epidermoid tumor is formed in connective tissue or a tumor of cylindrical epithelium in a lymphatic gland. A carti- laginous tumor which is developed in connective tissue or in the tissue of bone is indeed heterologous, but it is not so to the same degree as an epithelial tumor or a muscular tumor would be in the same place. But a still more important circumstance is this — that tumors engender certain liquid substances which we speak of under the name of 'juice.' This is the humor or juice of the tumor, of which much has been said." '• This parenchymatous juice is sometimes related to the cells, sometimes to the inter- cellular substance ; and, accordingly, it appears under the form of fluid, either intracellu- lar or intercellular, contained in the cells or interposed among them in a liquid state like serosity. Whenever a tumor contains much juice, it gives evidence of more troublesome qualities and it possesses to a high degree the property of infection. A dry tumor of the epidermoid kind is by far less dangerous than a moist one ; a soft cancer is much more to be dreaded than a hard one. " The more a tumor is poor in vessels, the less it will extend its infecting action beyond the neighboring parts ; but the more it is rich in blood vessels and lymphatics, the more it is traversed by the blood and lymph, the more the parenchymatous juices rcMons. J 23 arc in t'diitact witli tln' lilinnl. sd iinidi the iiiun,' is the iiifcctinii likely t,■ !,n,ur,„t hinnns affovl lln jxilitnt sol'li/ //iminj/i tin ir load iiijlin mi . Tlni^ i/k/io hi/ lh< ir oicii iiihcn nt jn'Of'- trtiis, imsjircfire i>f lliv (jnnvlh of l}ie parts in which tht// art- jtlitcctl, h- Granulation Tumors, or those composed of granulation tissue, including Follicular. Keloid, (.iuuiuiala, etc. E. Cysts. A. Innocent Tumors, Or those compo.sed of the normal adult tissue, vary with the tissues. They are innocent or benignant in that they do not, like cancers, infiltrate the parts in which they grow, but rather separate them, and are a source of trouble more from mechanical than other causes. When they interfere with life, they do so generally from pressure on important parts. They may stretch skin even to its rupture, but the margin of the skin-opening will be uninvolved in disease. In cystic breast tumors this is well seen. 1. Lipomata, Fatty Tumors, otherwise called " steatomata," are very common. They are fmiiiil wherever fat exists naturally in the body; and as this nuiterial is more especially deposited in the integument, it is in and beneath this that fatty tumors are most frequently met with. They occur at all periods of life from infancy to old age. and are even eontrenital. Thev attack the male .sex as well as the female, but tliev are three J 26 TUMORS. Fattv Tumor of Thiriy-Seven Years' Growth on Arm of AVoman set. C9. times as common in the latter. They are generally .single, but occasionally multiple. I have seen a ca.se in which the whole integument was studded with them, and under these circumstances they are usually small. It is impossible to a.ssign any valid cause for their development, hereditary and accidental influences having doubtful effects. They are troublesome only from their position and the deformity they occasion (Fig. 26), and are at times the seat of pain, Fig. 26. though such a .symptom must be looked upon as an accident due to their position. The.se tumors are. as a rule. " en- capsuled." although in rare cases they ai'e " continuous " or " diffused." This latter variety differs only from the former in that they are made up of smaller globules of fat and are more dense, while they are more com- mon about the nape of the neck and face than the encapsuled variety (Fig. 27) ; the large double chin is an example of the continuous lipoma, and congenital lipomata are generally of this nature. The encysted lipo- mata are most common on the .shoulder, thigh, and trunk ; some are deep-seated, as between the muscles of the limbs or within the abdomen or scrotum. Fatty tuniors at times shift their posi- tion — that is. they drop downward ; .'^everal such ca.ses have passed under my notice in which the tumor has travelled some distance. Such an occurrence is peculiar to this form of tumor and suffices to fix its nature. The DiAGNO.sis is not usually difficult. If subcutaneous, these tumors are '' lobu- that is. are defined by a distinct boundary, their cy.st-wall being formed by the condensed fibro-cellular tissue in which they are developed. To the hand of the examiner the tumor will feel more or le.ss firm and made up of lobes ; when frozen by the application of ice, it becomes harder. To the eye the tumor will, on raising it from its ba.se and distending the skin, appear dimpled, and in parts the skin will be quite drawn inward toward the new growth. If the tumor be deep, a doubt may be felt ; but practically the question is not of great moment, for it only refers to the nature of a .simple growth, and not to its treatment. Treat.ment. — When no neces.sity exists for their removal, tumors .should be left alone. When large and unsightly, cumbersome or growing, they should be removed by excision or enucleation. A single incision through the centre of the growth is the Vjcst and most expeditious method for turning the cyst out of its bed, which can be done readily by the finger. Where the growth is pendulous the whole .should be cut off. leaving enough skin to cover the wound. After the operation the edges of the wound .should be brought together by* sutures and strapping and supported by steady pressure : rapid union usualh- follows. Fatty tumors, when removed, very rarely return. Curling has recorded a ca-^e, how- ever, in which a recurrence. took place, but .so much connective tissue was present in that example as almost to remove it from the class of lipoma (Path. Tram., vol. xviii., 1867). I have also removed from the buttock of a lady a lipoma of two years' growth the size of a fist, having removed from the same part a like tumor twelve years previ- ously. The " continuous " fatty tumor should never be removed unless under very urgent circumstances. The operation is comparativelv formidable, so much dissection being required. In oliiMren. however, the.se tumors mav be dealt with. 2. Fibromata are tumors composed of " hard " or •• soft " fibrous tissue, the .soft being composed of masses of " connective " and the hard of " fiVjrous " or closely-packed connective-tissue elements. The " soft "' kind are found as outirrowths from the subcu- lated " and '■ encvsted Fig. Ditfused Lipoma of Neck. taneous tissuo, ami frer|uently in tl»c f'fiiialc external f^iMiihil orfjans ; they are known as " fibro-celliilar <;rn\vths." Tliey are nu-t witli also in tin- lower extremities under tlie form ot" " molusciim tihrosum " (rn/e Kij;. liS). Some eontain much fat, and thus a|)|)roa('h tlie li|Miniata. These tumors are mostly outgrowths, and appear as the softer polypi and eulaneous pendulous tumors. The polypi of the nose are the hest specimens of the looser kind of irrowths, as in eonsisteiiee they vary from a watery pellnciavies-Colley's ease.) some ot the softer kinds, mdeetl, give tlie idea of tfiud. Ihcy are tumors of adult life, being rarely met with in children. They increase in size with variable rapidity, the amount of fluid they contain materially affecting this feature. The pendulous outgrowths, mucous or cutaneous, at times swell out and at others contract, while those of the skin appear shrivelled and loosely encapsuled. Those of the genital organs may attain a very large size, some which are on record having weighed as much as forty pounds. At times these tumors inflame, slough, or ulcerate in an indolent, but in no way a typical, manner. The "firmer" kind are met with in many shapes. They are always solid, and mostly encapsuled. When, as in the uterus, mixed with the non-striped mu.scular fibre, the growth is known as ^- frbro-mnsrultir" or as a ^'■myomtt'" (Virchow's term). When as.so- ciated with cysts, it is called ^' Jibro-cijatic-/' and when with calcareous matter, '• Jibro- cnlcanousy These varieties are found chiefly in the uterus. Fibrous outgrowths, or pnb/pi are commonly met with in the uterus, nose, pharynx, and rectum. They have been found in the intestine and other parts. Fibrous tumors are found likewise in the uterus and prostate, and oramonnlhj in connection with the bones and periosteum, in the latter as an epulis. In tho.se about the bones the elements of bone or cartilage are usu- ally found. The fibrous outgrowths have no capsule, but are continuous with the tissue from which they spring, and are made up of fibre tissue more or less closely packed and arranged in bundles or in concentric circles ; they are but feebly va.scular. Those of the uterus are the most typical (Fig. 20). Fibrous tumors are always encapsuled and have a tendency to assume an ovoid or globular form when not confined ; but when eompres.sed or bound down by surrounding ]»arts, they take an irregular lobular .shape. In structure they are very simi- 'lar to the outgrowths. Fibrous tumors are firm, and occasionally most unyielding. They are slow in their increase and give pain only from their po.sition. When bound down by a dense fa.scia or situated near a nerve, they cau.se much distress. They only interfere w-ith life or comfort mechanically. They are usually single, except in the uterus and when in connection with the nerves. As they come under the notice of the surgeon, those connected with the periosteum or bones, called jvrlostcal sorconui. are the most common, and of all the bones the jaws are the most frequently affected by them. They are chiefly periosteal and appear as outgrowths {vuk chapter on '• Tumors of Bone "). They are found in the pharynx, on the lobule of the ear. and on the nerves as " neuromata." The subcutaneous fibrous tumor is a hard movable tumor beneath the skin. It is usually small ; but when of a less dense kind and more nearly approaching the fibro- cellular tumor, it may attain a large size. Under these circumstances the skin will become part of the tumor: it will then often ulcerate and allow the growth to protrude 128 TUMORS. Fig. 29. through the opening and ulcerate, or even slough, and thus these tumors sometimes bleed freely. At times fibrous tumors seem to grow from the deep fascia. Treatment op Fibrous Tumors. — Excision is the only treatment which offers any prospect of success ; and when these fibrous tumors are removed, a recurrence is rarely met with. The fibro-niuseular, fibro-cystic, and fibro- calcareous tumors are mostly uterine. 3. Chondromata, or cartilaginous tu- mors, iire most commonly met with in connection with bone, but they are found in the parotid or sub- maxillary regions, the soft parts, as the testicles, inter- muscular septa, and other parts. They appear, as a rule, in young subjects, in people under middle age, and are far more common, accord- ing to my own notes, in the female than in the male. They are usually slow in growth, the majority having existed years before the patient seeks advice. The instances of tumors of rapid growth on record arc rare. These tumors, when not outgrowths, are always encysted and have a smooth, tense, and elastic feel. In some examples they are uniform and even, in others bossy and nodulated ; they rarely cause pain, and produce anxiety simply from their po.sition and size. Tho.se in the parotid or submaxillar}' region appear to grow su- perficially and to be movable, but they often dip down deeply into the tis.sues, and considerable care is required in their removal. In a case treated by my colleague, Mr. Durham, the tumor appeared more as a pharyngeal than as a parotid growth. As often as not they are very adherent to the surrounding parts. These simple parotid tumors rarely involve the facial nerve or cause When the cartilaginous tumors grow tcifhiu bones, they Fibrous Tumor. (Prawing 307"-, CJuy's Hosp. Mus.) C^^***'*^^''**,,^^ paralysis, as do the cancerous, expand them into a thin shell. Cartilaginous tumors are usually innocent, and consequently only separate the parts between which they are developed. They never Fig. 30 involve the integument by infiltration, but only (fi 71-^ — ^__ Stretch it ; in exceptional instances they excite ■^^,J^~"'~>--,.,_^ inflammation and ulceration in the skin, with sub- ^^Nisiijj^s^^^^ sequent perforation ; they do not affect the sys- tem through the glands, although it must be added that rare examples are on record in which cartilaginous tumors have returned and affected the lymphatic system like a cancer. Sir J. Paget has recorded such an instance in the Mcd.-Clu'r. TnaiK., 1855, and De Morgan in the Path. Trans., vol. XX. The section of a cartilaginous tumor is fairly characteristic (Fig. 30). It cuts cri.sply and pre- sents a smooth surface ; it may appear of one mass or made up of many lobules. In some ca.ses the consistence of the tumor is close and is composed of translucent or bluish masses of fcetal cartilage, as is best seen in the periosteal forms. In others it is loose and granular, as in those expanding the bones. In many of them fibrous or glandulnr tissue is intimately mixed with the structure of the tumor, the parotid tumor affording the best type of this kind. In the cartilaginous tumors of bone, bone elements are always pres- ent ; in those of periosteum, fibrous elements; and where glands are involved, glandular .structure. When cartilaginous tumors .soften down, cysts are found, usually containing a dirty brown serous fluid, or simply filled witli broken-down tissue and pus or with a more tenacious synovial kind of fluid. Microscopically, cartilaginous tumors present diverse forms, simple fcetal cartilage cells, embedded in some cases in a hyaline or in a granular matrix, in others in a fibrous or glandular stroma, or even both in different parts of the same growth. The most typical form is that in which the cartilage cells are grouped together in masses surrounded by fibre tissue. From this type great deviations occur, the cells being more or less scattered Section of an Enchondromatous Tumor e.xpanding Metacarpal Bone. TCMOIIS. 120 hctwcen the Bhros. In some instances the nuclei of the cells are free and hunierr)iis, in others they are tilled with granules or oil-globules, ajiparently degeneralinfj. Occasionally the eartilaj»'e cells are developing and take on the mature form of hone cells (Fig. 40). TuK.\TMKNT. — The removal of the cartijaginous growth is the oidy efficient treatment, but the practice must be determined by the position of the growth and all the other points with which the tumor is clinically surrounded. When removed, a return rarely takes place. Ca.>us tumors of bone will be considered under the head of '• Diseases of Bone.' 4. Osteomata, or osseous tumors, naturally come to be dealt with after the cartilairinous. for the two elements arc usually conibincd ; and as in the enchondromata traces of bone may be found, so in the os.seous tumors traces of cartilage may exist (Fig. 40). These are found in several forms, as exostoses or bony outgrowths, as ivory or perios- teal exostosis, and as tumors of bone. The ivory growth is peculiar to the bones of the skull. The cancellous exostosis is almo.st always developed through cartilage and made up of tissue precisely similar to the cancellous tissue of bone. In some cases it is covered with a thin casing of compact bone, like the cartilaginous tumor growing within a bone, but in most it is covered with a layer of cartilage, by the ossification of which it grows. A diagram illustrating these points will be found in the chapter dealing with exostosis, and the clinical aspect of the subject will be again considered in the chapter on " Tumors of Bone."' 5. Adenomata, glandular or adenoid tumors, are new growths simu- lating more or It-.-s perfectly the gland structure in the neighborhood of which they grow, and are not hypertrophies of the gland, but distinct tumors. In the breast the usual innocent tumor of the organ is of this nature, and is called adenocele ; but it is also found in the prostate, uterus, lips, tonsil, thyroid, and integument. Fig. 41 represents admirably the microscopical features of the adenomata as a cla.ss, and Fig. 31 the appear- ance of such a tumor in section, some parts being solid and others composed of pendulous intra-cystic growths. Thev are generally growths of young life, and are found during the active period of a gland's existence. They are always encapsuled. and can usually be turned out of their bed with ease on dividing the capsule. They generally assume a rounded or ovoid shape, and are distinctly movable beneath the integument which is not involved. '• On section," says Paget, " they commonly appear lobed or intersected with partitions of con- nective tissue and are pale, grayish or yellowish-white, in some specimens looking trans- lucent and glistening; in others, opaque : in nearly all. acinous or glandular. To the touch, some, especially the white and more opaque, are firm, tenacious, and elastic ; others, especially the yellow and more glistening, are softish, brittle, slippery, and succulent, with fluid-like serum or synovia. Not rarely cysts are embedded in the solid growth, and these are filled with serous or other fluids like tho.se which are found in the barren cy.sts of the mammary gland itself. In the labial and parotid glandular tumors portions of cartilage or bone may be mixed with the glandular structure, and sometimes, chiefly in the mamma, the glandular tumors appear as if formed wholly or in part of clusters Fig. 31. of small sessile or pendulous growths, which fill cysts or parti- tioned spaces ; thus they indicate their relation to the proliferous cy.sts and suggest that they originated in such cysts. The textures around the tumor are usually quite healthy, altered only by displacement." These glandular tumors are often single, but at times multiple. Thus, in the breast they may be many and so loosely encapsuled as to move about as in a bag : in the lips they are commonly numerous : while lymph- atic glandular tumors are almost always multiple. They grow with very variable rapidity Adeno- :u>trarinc the Pathological Appearances .-■1" AdeDoid Tumors. 130 TUMORS. — at times more slowly, at others with great rapidity. They require removal simply from the inconvenience caused by their mechanical jiressure. Treatment. — To remove them it is only necessary to divide their capsule and the soft parts covering them in and to enucleate them. This need not, however, be done under all circumstances, for these glandular tumors not only cease to grow, but at times disappear ; thus operative interference should only be entertained when the growths are large or increasing or very painful. jMedicine does not appear to have any influence in checking their growth. The glandular tumors of special regions will receive iintice in the different chapters devoted to their coiisidcratioii. PapilloiTiata are found in the outside or inside skin and in the mucous membrane, while instances are on record where they were found on serous meniln-anes. On the skin they occur as warts, cauliflower or sessile, and as condylomata. .Some of the horny skin- growths arc of this nature. On the mucous membrane they occur on the lips, larynx, hard and soft palate, tongue, and rectum, and as villous growths in the bladder and rec- tum. They seem to be a mere delicate outgTowth of subcutaneous or submucous tissue, with their natural epithelial covering, at times involving the gland structure of the part. They are usually innocent. Neuromata, or fibrous tumors developed in and about a nerve, will be considered in a later cliai)tcr, as will the angiomata in chapter on the " Diseases of the Vascular System." Lymphoma is a disease of the lymphatic glands which is at times local, at others general. When local it has, as a rule, local causes ; when general, constitutional and is associated with leuca3mia or leucocythiiemia. The glands are, as a rule, movable in the surrounding parts, and can be shelled out. In exceptional cases they are matted together, as in cancer, and, like it, are also dis- seminated as secondary, growths. (For " Histology " viiJc Fig. 42.) B. Semi-Malignant Tumors. 1, Sarcoma. — The semi-maligmmt tumors, or those composed of embryonic con- nective-tissue elements, include what are known as the '-sarcomata" and " myxomata," and these clinically present a vast variety of shapes and types. They approach the sim- ple growths in that they do not infiltrate tissues, but separate them ; and they approach the malignant in that they are prone to recur after removal, and that on each recurrence they come nearer the characters of the cancer. To the naked eye they are succulent, with every degree of solidity, but a section does not give milky juice on scraping, and it never presents the concavity like a cancer. in some cases, where recurrence has taken place, the second tunnn-, doubtless, has been simply the external manifestation of a small growth which existed when the original tumor was removed, or the increased growth of a portion of diseased tissue that was unconsciously left. On two occasions when removing a mammary adenoma I have exposed a minute growth of a similar structure by the incision made through a portion of the healthy mammary gland to reach the principal growth. In both these cases, had the small tumor been left, a recurrence would have been recorded. In cases of recurrent fatty tumor or of the soft fibroma it is highly probable that a small portion of the tissue was left. On one occasion, when I was enucleating one of these, of several years' growth, from beneath the fascia covering the scapula, I discovered two smaller growths which might have been overlooked and would certainly have grown. f]ach tumor as it recurs generally becomes less solid, more succulent, and more rapid in its growth. With each recurrence the cell elements increase in proportion and in all ways ; " later formed tumors assume more of the character of malignancy than the earlier." All these sarcomatous tumors are composed of round, elongated, oat-shaped, caudate, nucleated cells like those found in granulation and embryonic connective tissue (vide Fig. 43). It must be observed that these tumors, as a rule, attack the young and healthy. They grow from a fascia or aponeurosis, are of slow growth, particularly at first, and destroy life only after many years and from local causes. They return either in the spot from which they originally sprang or from its immediate neighborhood. They simply aff"ect the part mechanically by separating and surrounding tissues, but never by infiltrat- ing them.' The skin is stretched over the tumor, but never involved in it; and if destroyed, it is by ulceration from overdistension, while the absorbent glands are never secondarily involved, even in extreme conditions. Such tumors are to the hand more or less fibrous and lobulated, their fibrous feel being much influenced by their rapidity of 77 -MORS. 131 Fui. ■:± Sarcoma of Bone. (I'rep. V hands of lihres; and when it oriixinatcs in hone, it mav he similarly divided hy thin plates or outgrowths of ossific matter, these plates or laminn; heini: some- times distinctly seiiarate. at others so closely packeil toircther as to form .somethinjr like a skeleton tunnjr (Fig. ^^2), the sarcomatous elements clothing the bony outgrowths or surrounding and covering them in. For diagnostic purposes the detection of the.se bony plates is of great value. The treatment of recurrent tumors need Tiot differ from that of the inimceirt. for as long as the disease is local there is a reas((nahle hope that it will at last cea.se to recur after reinnval. Myeloid or giant-celled sarcomatous tumors are as primary growths generally I'ound associated with bone, either growing from the bone, as in " epulis." or more comnioidy in the bone, and when in this position usually in its articular end. The term was given to the class by Paget on account of the like- ness between its cells and tho.se of fuctal marrow. Lebert called them " fibro-plastic,'' and Virchow •• giant- celled sarcoma."' When these tumors are periosteal, they have the clinical features of a fibrous growth ; Avhen within the bone, they appear as chronic expansions of the articular extremity or shaft. When large and so expanded as to have burst through their osseous case, they appear cystic and semi-fluctuating, even to the extent of being pulsatile. They are usu- ally slow in their progress, and often painless ; and it is fair to supjiose that many of the cases of cystic expansion of the articular extremity of a bone are due to myeloid disease. The disease is one of youth and young adult life, and the growth is usually single. It is not connected with any cachexia or glandular enlargement, as happens with cancer ; and when removed, it rarely returns. Instances of recurrence, however, have occurred, and I have seen one. Sir J. Paget has recorded others. A myeloid tumor presents in section a peculiar appearance. It may be solid or cys- tic in variable degrees; osseous matter, fibrous matter, or fluid may exi.st in different pro- portions ; yet in every specimen the cut surface will present blotches of a pomegranate crimson or of a darker blood color, these tints mingling more or less regularly with tho.se of the other tissues. Under the microscope the characteristic polynucleated cells are seen ; the.se are large, round, or irregular cells containing manv — even ten or more — oval, well-defined nucleated nuclei floating in a clear or granular substance. They are found in masses or distributed throughout the tumor between the bundles of fibre tissue. They are diagnostic of mye- loid disease. With these cells Lebert's caudate or spindle-shaped cells are also found {cH/r Fig. 4:-I). Melanotic sarcoma is essentially a tumor containing pigment, having its origin in a natural tissue, as in the choroid of the eye or in a mole in which pigment exists; but what it is that determines the development of the.se growths in tissues that have had a lifelong exi-stence remains to be explained. The black sarcomata have, however, one peculiarity, and that is in their tendency to multiplicit}-. In this thev' are often mo.st remarkable : the skin and subcutaneous tissues at times become studded with melanoid growths of all sizes and shades and colors. Fig. o3 is taken from a woman over who.se whole body melanotic cancerous tumors were distributed, the disease having originated in a mole which I had previously excLsed. Pathology. — If it were necessary to adduce a forcible illustration of the fact that a tumor when first developed in a part partakes, iji a measure, of the nature aiul peculiarities of that part, and even when repeating itself in the lymjihatic glands and internal organs still preserves the characters which it originally ac(|uired from the seat of its primary 332 TUMORS. Melanotic Sarcoma. ( From Model, Guy's >rus.) development, no better could be adduced than that derived from the natural history of primary and secondary melanotic growths; for a melanotic sarcoma always grows from a part which naturally contains pigment, and a mole is unquestioriaVjly its commonest seat, while pigment in some of its forms is almost always to be met with in all its secondary growths. It may be. perhaps, that the secondary glandular enlargements in their rapidity of growth out.strip the tumor from which they originally ini- liibed their peculiar nature ; nevertheless, their true cha- racter is maintained and pre- served to the end. This sar- coma, as a rule, is of the soft form and runs a very rapid course, an extreme example of melanotic sarcoma, indeed, presenting all the worst features of a cancer. In rare examples of this disease the melanotic pigment may be found in the urine (Fagge, Path. Soc. Trans., 1876). It has, however, peculiarities of its own, to which attention will be subsequently directed. The oxfeo sarcoma and chondro sarcoma will receive attention in the chapter devoted to the tumors of bone (Chapter XXXII.). They are all probably only modifications of. the medullary cancer affecting bone, although it may be mentioned that exceptional eases are on record wliere an osteoid cancer originated in some intermuscular interspaces. 2. Myxoma. — These tumors are very like the soft fibromata and certain fatty tumors. They are encapsuled, very soft and succulent, and exude a peculiar mucous juice. They are most common in the subcutaneous or mucous tissue, but are found everywhere. They are seen as parotid growths, and often mixed with fibrous or cartilag- inous elements. They are doubtless often mistaken for colloid cancer. In the typical mijxoma the tumor is less firm but more elastic than the sarcoma ; its nature is far less homogeneous and presents less well-marked interlacing fasciculi of connective tissue, and from the meshes of this tissue will flow a variable stream of clear, translucent, viscid mucus. The fibres of the connective tissue are visible under the microscope, but in smaller bundles and more drawn out. Abundance of cells, also rounded, elongated, branching, and even anastomosing, together with nuclei, will be found to fill the cavities formed by the confused network of delicate fibres of which the tumor is composed. In the structure of the myxomata fat often forms an important element; glandular elements may also be found, their presence being determined by the position of the growth and the propinquity of a gland. Bone or cartilaginous elements are at times mixed with the others (Fig. 44). Mi/.romnta are not rare about the angle of the jaw, nose^ breast, and abdomen. They are met with also in the extremities and in the eye, as well as in the delicate connective tissue of the nervous system, particularly of the brain, and also of the nerves. When attacking the brain and nerves, such growths are commonly found in the young. Vir- chow has named them fjliamaUi. (Fig. 43), the cells being of a small round or pointed form, embedded in granules, and held together by delicate fibres. In some cases the fibre element approaches the firmer kind of fibro-cellular tumors (Fig. 43). Treatment. — Excision is the only practice that can be followed, although this opera- tion need not be performed when the tumor is small and not progressing, especially when it occurs in aged people. Good success usually attends the practice. In the firmer varieties of myxomata a return of the tumor is not to be expected, but in the softer, where cell elements predominate, the risks of a return are great. C. Cancerous Tumors. What is a cancerous tumor ? Of what is it composed ? and. How can it be recognized? are questions which the student is constantly asking ; and few are more difficult to answer with accuracy or precision. Pathologically, a cancerous tumor is compo.sed of cells which more or less conform to an epitlictiiil type, but the student must be prepared in all — at any rate, rapidly growing — tumors to find a great variety of cell forms ; and it may with truth be said that the CANCEROirs TV MORS. 1;};J iiuire tlie ci'll elements prodnniiiiutc in u i:r(»\vlli. ami the inmc tliey apiintadi an epithelial type, the Iedullary cancer is, however, the special form that appears as a congenital tumor and which attacks children and young adults, and may be called '' the cancer of young life." These growths form very rapidly and run their course far more quickly than the harder kind. They increase so tast that they push away the tissues with which they are sur- rounded more like the innocent tumors which separate them ; their capsules prevent that general infiltration of the parts which is observed in the infiltrating form. It is found, although rarely, in the breast, yet more frequently in the intercellular tissue and about the periosteum and bones. It is the usual form attacking the eye. uterus, tonsil, testis, and ovary, the bones and cavities of the head and face appearing peculiarly liable to its inroads. These sid't cancers usually appear as deep-seated swellings, and when not bound down by fascia or connected with bone are rarely painful ; but when so situated, a gnawing pain or ache is a frequent concomitant. As they progress and become more visible they may present either a nodular lobulated or a .smooth and uniform aspect, but in either case the integument covering in the growth will be traversed by many very large and dilated veins ; while in .some instances the growth has a blui.sh congested aspect, as if filled with venous blood. These tumors are often so vascular as to pulsate, and thus simulate an aneurism. Such a symptom, however, is mo.stly observed in those connected with bone. To the touch the swelling feels soft and fluctuating, often giving the idea of fluid ; and should the surgeon, to satisfy himself upon this point, puncture the tumor with an cxploring-needle. blood will freely escape, and with it .some creamy tissue, which under the microscope will be seen to be made up of cells and nuclei. When these soft cancers have burst through their fascial envelopes, they grow more rapidly ; and when they have made their way through the skin. they, as it were, pulp out, and project much as a liernia cerebri does after ctjmpouiid fracture of the skull. The .«oft succulent granulations and blood-infiltrated tissues that project suggested to Mr. Hay of Leeds the term ■• fungus haematodes." AVhen a soft cancer is filled with blood, it is kncjwn as a " h;«matoid variety."' When they appear in the parotid region, they usually, if not always, pi'oduce paraly- sis of the facial nerve — a clinical symptom, I think I may say, never found in the ordinary innocent parotid tumor; so that when present this symptom is of value. As a rule, how- ever, this soft cancer surrounds nerves and vessels without materially pressing upon them, large vessels and nerves being often found passing completely through their substance. The section of a soft differs from that of a hard cancer as the '• infiltrating " differs 136 EPITHELIAL CAyCER. from the '• tuberous " (compare Y\rt;ans. W Inn it spreails lueally, it may us a eaiioer inliltrate and invade every tissue \vlii(di it reaidies. I liav*; .seen it more than once origi- nate in skin and end in a total destruction (d'a hone (ridr (/iii/s I/osj). Jie/)., 1.S75). Ispithelial cancer is made up (d' c( lis whicdi difler luit littlt; Irorii those of ordinary epitludium, tliouuh they are grouped very ditVerently ; they iidiltrate tlic tissues in which thev an; |)laeed or are cdustered toirt'thi-r in masses, tlu'se masses heiiij; deseril)ed as " ue.sts" (Fii;. d;')). The surface (d' an cpitludial cancer lu.ay he dry ami warty or ulceratin;^ ; when uieer- atiuLi, it will he, like all cancerous sores, irrejxular. and will ^v 3^^ / \ / Rodent Caiicer of the Face. (From an origi- nal diawinj; of'.sir Charles Hell's, contained in the niiiseiini nf the Middlesex Hospital, and recojinized hy Messrs. Shaw and f'anip- hell with Mr. do Mnrpran when he said " that Jill that cniihl he said with rf is ahout one in every liK.l cases. Strikinir examples of the hereditary nature of canc(;r are met with in practice, hut they are not more strikinjj; than, if so much so as, the hereditarines.s of ;rrowthsof a sim- ple kind. Sir J. l*airet has pointed out, however, that when a local disea.se or deformity is inherited, it passes from pro^'cnitor toort"s]»rin^ in the same tissue, if not in exactly the same place; whereas, when a cancer is hereditary, it may hreak out anywhere. "The cancer of the hreast in the parent is marked as cancer of the lip in tin; oflsprin<; ; the cancer of the cheek in the parent becomes cancer of the bone in the chihl. Tliere is in these cases absolutely no relation at all of place or texture." Cancer is a di.sease of adult life, although it may attack a fent, has in it tlie elements of a successful plan, but has not yet been brought to any available state of per- fection. Fattv tumiU's may be destroyed by the introduction into their substance of a few drops of deliipiescetit chloride of zinc, but cancerous tumors do not ajipear amenable to a like remedy. l)r. Hroadbent believes that he has succeedetl b}' injecting a li'.S7'.V. 143 W'licii siirL'if:il trcatinciit is calli'il l'(ir./H////V////r means had better he primarily adopted. This trcatiiii'iit consists in iiit'iily ihawiiiu nH the ooiitciits oi' tlie cyst hy means of" a trocar and cannhi or the '• aspiratiir.' Sliuiilil tin- fluid n,'-coih'ct rapidly, the operation luav he repeated. In pi-rlorinin^ tins operation tin; surgeon, to j;uard a^rainst jmnetiir- iiij; any oi' the snpcrticial veins or deep vessels, sliould recall their jiosition heion- pune- turin,L'. Slioulil tlii'sc measures i'ail even after several repelitiuiis. the hest jtrai-tiee is to intro- dtice into the cavity of the cyst a draina;:;e-tnl»e. When the tappirijr has induced some sup])uvative action, the oj)enini: may he eidarjred and the tuhe inserted ; hut when the cvst is lar<;e, it is well to pass the tuht; completely through it. 'J'liis may readily he done hv means of a lonij trocar and eanula, such as that (Muployed for puncturinji the hladder per rectum, the pilot try the history of the ca.se. Congenital cystic hygroma or tumor is a peculiar affection, the nature of which is not clear. It may appear in the neck, its most conimon seat, or elsewhere, as a cystic swelling or as a more or less compact .solid growth, the cystic element varying in each case. It is always deeply j)laced beneath the fascia and dips down beneath muscles, tendons, and vessels. The skin over the tumor is, as a rule, healthy and movable ; but in some cases, from the lobulated nature of the tumor, the skin is dimpled as in a lipoma. From its appearance and position it may simulate many other affections, such as naevus or spina bifida ; but pressure upon it has no influence in lessening its size. The di.sease has a tendency to disappear naturally, though at times it may grow rapidly. In some cases it inflames and then shrinks. When treatment is absolutely called for, that by setons, as suggested by ]Mr. Thomas Smith (^V. Baith. JIosp. Rtp.^ ISlK!), is the best. The knife should be employed in excejjtional cases alone. The value of injection of iodine or INIorton's iodo-glycerine solution has yet to be tested. Mucous cysts are found wherever mucous glands exist, and are caused by some obstruction to the escape of the gland contents. They contain highly tenacious mucus- like liquid albumen. They appear on the mucous membrane of the lips as hihinl ci/atA, and are small, tetise, glol)ular, painless swellings. They are found within the cheeks, upon the tongue and gum, particularly of the upper jaw and antrum, and very commonly beneath the tongue, as snhlhignal mucoux ci/sfs^ when they have been described as cases of '^raniila." Such cysts, however, are now known to be due to okstruction of the ducts of Kivini's mucous glands, and are not necessarily connected with the salivary organs (Fig. 214). These cysts may develop about the larynx and cause obstruction, and they have been found in the oesophagus. As hihinj and vnginal murjnis ci/stx they appear as tense, globular tumors beneath the mucous membrane of the parts. I have seen them as large as an orange. These cy.sts generally contain thick, ropy, mucoid fluid of a color- less or slightly yellow tint. Occasionally the fluid is mixed with blood in diflferent pro- portions. I have seen them contain black, milky, or coffee-ground fluid. Sometimes they inflame and suppurate and run on into abscesses. Treat.ment. — Small labial cysts may often, on dividing the mucous membrane over 144 CYSTS. I'hetn, be turned out as a whole ; but the sublingual and larger vaginal cysts, as a rule, cannot be thus treated. A free opening into them or the removal of their external wall, and the introduction into the cavity of a plug of lint soaked in iodine to excite suppura- tion, may at times suffice to bring about a cure, but not always. In the so-called ranula it may be tried before other practice is attempted. In the sublingual, labial, and vaginal cysts I have for some years been in the habit of seizing the upper surface of the cyst with a pair of forceps or tenaculum and cutting it off with scissors, thus freely exposing the deeper wall. In the sublingual this practice is, as a rule, successful without further treatment; but in the labial and vaginal cysts I have, in addition, generally destroyed them by the application of some caustic, such as nitrate of silver or carbolic acid, to the exposed surface, after which the wound will granulate healthily. When these cysts can be excised, the operation can be performed. The mucous cysts of the antrum and u]>per jaw will be described amongst the tumors of the jaw. Cutaneous sebaceous cysts, as they come under the notice of the surgeon, appear as ^^ coni/eiut(ir' and ^'' dcijuircd" tumors. They are analogous to the mucous cysts, the glands of the tissue being in both instances at fault. Some are doubtless caused, as first described by Sir A. Cooper, by the obstruction to the orifice of the sebaceous glands of the skin, for this occluded orifice may often be seen as a small, depressed, black umbilicated spot upon the tumor ; the contents of the cyst may often be squeezed through this orifice, or into it a probe may be passed. In a larger proportion of cases, on making an attempt to raise the skin from the tumor, a dimple or evidence of connection between the two will be visible, thereby revealing its nature. But in other cases no such obstructed- duct, or even cutaneous depression, can be observed ; and, although the tumor may be developed within the integument, it is probably a new fornuition, an adenoid or glandular skin tumor. The congenital sebaceous tumors differ from those usually met with in the adult, or the acquired form, in that they are more deeply placed and mostly lying beneath the fascia of the part, occasionally beneath the muscles ; they are rarely cutaneous. They are more common about the orbit and brow than any other part, the external angle of the eye being their favorite seat. They appear as small, hard, semiglobular masses deeply placed, and are often, indeed, upon the bone. Cases, too, are on record in which by their presence they have produced perforation by absorption of the bone. In the ear this result is not rare. These cysts are thin-walled and often contain liquid secretion, some- times of a pearly whiteness and not rarely mixed with hair. I turned a complete ball of hair out of such a cyst on one occasion, though usually the hairs are fine like eyelashes and are mixed with the sebaceous matter. The contents of these congenital cysts are rarely offensive. The acquired sebaceous cysts may be found on any part of the body that is cov- ered with skin. They are more common on the head and lace than elsewhere, two-thirds of all cases occurring in these regions. When on the scalp, they are known as "7nital. It eoiitained liijiiid oil {r„tl,. Soc. Trans., vol. .'UJ, 1.SS2). Tkkatmknt. — The oidy cor- rect treat incut of tliese sebaceous or skin cysts, wlicthcr wlioh*, bro- ken, or l"un<;atini;-, consists in their removal. In rcniovinji' " wens" or iivqin'n(/ cysts, liowever, it is not necessary to be too careful in di,s- sccting them out entire, and the most eft'ective method is to slit open the tumor with a bistoury and then turn it out with the forceps or handle of the knife. In the re- moval of sebaceous cysts from other parts of the body the capsule of the c^'st should be taken away, while in the funjrating tumor the whole mass ought to be excised. In the treatment of the roiujenUal tumor it is always better to try and dis.sect out the cyst entirely ; but nothing is more unsatisfactory than operating in such cases, for the cyst is always deep, its capsule thin and adherent, and any attempt to dissect it out as a whole is too often foiled by the burst- ing or puncturing of the capsule and the escape of its contents. When this occurs, the surgeon must take away as much of the capsule as he can and then close the wound, a good result following, as a rule, though at times a recurrence of the growth will ensue. The fear of erysipelas after these operations is really almost groundless. It niav arise, but out of more than one hundred cases consecutively observed I have not seen one example. Pvicmia may follow this, as it may any other minor operation, but not more frequently. When patients are cachectic, such an operation of expediency as that for the removal of a " wen " had better be postponed ; for under low conditions of health blood-poisoning is likely to follow. Should, however, its removal be urged, this may be ♦lone by the injection into the cy.st of some caustic, such as a few drops of deliquescent chloride of zinc, of carbolic acid, or the external application of nitric acid or potassa fusa, to produce a slough througli the skin, when the contents of the cyst may be turned or drawn out. Sebaceous Tumors in .Scalp, and Horn. THE MICROSCOPIOAL ANATOMY OF TUMORS. By Dr. Moxox. Every texture of the body in its earliest embryonic stage of development is alto- gether composed of cells which have in their primitive condition no noticeable sub- stance between them. As the texture progresses in its development the uniformlv cellular composition of its primitive substance undergoes modification. Some of the cells become separated by intercellular substances of various kinds ; others change to capillaries, lymphatics, and nerves ; yet others retain their cellular form and remain in close contact with each other. The general result is that when the .«everal textures of the fully-developed frame are studied in the course of minute anatomy, each texture is found to shew in its ultimate construction some remains of its cellular oriirin. more or less evidently recognizable. In some tissues, such as the epithelial coverings and linings and the cellular parts of the lymphatic glands, of the thyroid, etc., the cells remain always distinct from each other, although in close mutual contact. In the several kinds of tissues of the connective class, including cartilage, tendon, bone, etc., a large proportion of inter- cellular matter separates the cells, this intercellular matter taking the form of hyaline or elastic substance, as in cartilage ; of fibres, as in connective tissue and tendon ; or of cal- cified substance, as in bone. The cells remain separate in cartilage, but in the other tissues of this class they send out processes which unite to form a network throuirhout 10 146 THE MICROSCOPICAL ANATOMY OF TUMORS. the calcified or fibrous intercellular substance which constitutes the greater part of the tissue. Tumors of Nonstriated Muscle. — In the proper substance of mu.^^cle and nerve, tissues endowed with special dynamic powers, the original cells generally blend more completely, composing tubes or fibres. These tissues show very little disposition to form tumors, or even to share in their formation. There is one exception to this indiffer- ence in the case of non.striated muscle : the fibres of this kind of muscle retain to a large extent their embryonic characters and never quite lose their primitive cellular composi- tion ; the original cells are comparatively little altered and remain still distinct. And with these embryonic characters the fibres of nonstriated muscle show a capability of extensive new growth ; rapid production of this tissue occurs during adult life in the pregnant uterus. Ana tumors of nonstriated muscle fibre are not uncommon in the uterus and elsewhere. This texture is, indeed, of great interest pathologically, as show- ing the association of a power of new growth in a highly endowed tissue, with a persist- ence of embryonic form in its elementary fibres. It is perhaps the most striking example of what is generally true in both normal and pathological histology — namely, that with embryonic form in texture elements goes always power of increase and multiplication. Blood Vessels in Ne"W Growths. — The behavior of the blood vessels in the formation of new growths is an interesting field of study, in which useful observations may yet be made. It will be found that the blood vessels which arise in tumors com- posed of normal adult texture, such as bone, fibre, etc., are themselves composed of the textures proper to normal adult blood vessels ; but, on the other hand, the blood vessels of tumors which are composed of embryonic substance are themselves also composed of more or less embryonic cell-forms. The constitution of the blood vessels in any growth must be considered when we are endeavoring to throw light upon those conditions which enable a tumor to infect the blood passing through it, so giving rise to secondary tumors in the course of the circula- tion. There are tumors in which blood vessels attain to undue proportion, and sometimes tufts of blood vessel make up almost the whole of a new growth. Such tufts, projecting on a free surface, bring danger of serious hemorrhage. Activity of Embryonic Cells. — The discovery within a tumor of any large proportion ot embryonic cells may generally be taken as a sign of active growing power. Such cells are known by their indefinite transitional shapes, their large nuclei and many nucleoli. These cells were formerly looked upon as special to the more dangerous kinds of new growth, and were spoken of as " cancer cells." It was thought that one might know a cancer by the presence of such cells. But you cannot find out the character of a new growth by scrutinizing its cells indi- vidually. It is true that .some kinds of tumor contain a large proportion of cells that are so far peculiar as to be almost characteristic, such as the giant cells in a form of sarcoma and the lymphoid cells of lymphoma ; yet cells of either of these kinds are met with in other forms of tumor. Indeed, it is now generally admitted that the hope of being able to determine the nature of a growth by the study of detached cells must be given up, and the character of a tumor must be estimated by a general consideration of its whole struc- ture, for experience has established the fact that the structure of a tumor indicates its character ; so that dangerous tendencies are constant in tumors of certain construction, such as carcinoma, and are as con.stantly absent in the case of tumors of a wholly differ- ent construction, such as adenoma, whilst in yet other tumors there are lesser degrees of danger. Xow, in every tumor the new material is developed, like the natural tissues of the body, from embryonic cells. And in any growing tumor some proportion of such cells is always to be found in the part of the tumor then in the act of development. But the several kinds of tumor differ exceedingly in the proportion of embryonic and adult material contained in their composition, some appearing to the naked eye to be alto- gether made up of an adult texture, whilst others are throughout constituted of embry- onic substance; and it may be said that the more embryonic substance present in a tumor, the greater will be its rate of increase, and generally the greater the danger attaching to it. A tumor whose substance differs much from any of the natural tissues is generally a tumor endowed with the embryonic ((uality of rapid increase, and hence is a dangerous tumor ; whilst a tumor whose composition resembles that of any fully-developed tissue, such as bone, fat. ligament, etc., is generally a tumor of .slow growth and comparatively little danger. The most important exception to this general rule is in the case of carti- lage. Tumors composed of cartilage may grow rapidh' and prove dangerous, but it must Till-: MICROSCOI'ICM. AS ATOMY OF TI'MollS. 117 be remembered that, altlidugli cartilaj^e is a tissue of the adult liuiiiuri frame, yet there is such a thing as eml)ryoiiie cartihige ; and thus, indeed, cartilage may claim to he regarded rut her as emhryouic than as adult. When the substance (d" a tumor develops into adult tissue, the tumor so lormed is always ciunposed of one as.sively mechanical, either in serving as adjuncts to the luuscuhir syslrui or l»y tillinii up interstices between (»rj;ans of the body or by entering! into textures to support tlu'ir component j)arts, bhjod vessels, etc. Those connective tissues wliicli penetrate info iiiiy ol' tlie organs of the body are modiii<-d in consistence and in arrangemt'Ut of ilnir cIcnKiits according t(j the re<|uirements of the organ. Thus, in the brain the coniu'ctive tissue, caMed "neuroglia," is very dulicate and soft and has scarcely any distinctness. Also the connective tissue which enters into the lymphatic glands bcconu-s reduced to very soft fibrillar matter between the lyniph cells. In these instances, and in others, the connective tissue thus comes to have j»eculiarities and to constitute strongly-marked varieties. Vet all connective ti.ssues possess this com- mon feature in their elenuMitary structural composition — that they are made up lA' cell- ular bodies between wliich their proper substance forms an intercellular matter. The relation of sarconui to the connective class of tissues appears to be thi.s — that when one of these tissues i.s produced very rajtidly it has no time for its intercellular matter to ac(|uire the i)roper characters, and so remains indeterminate, while it also is small in quantity, the cells greatly preponderating. Thus, any of the normal connective tissues may produce by rapid development a tumor of .sarcous tissues or sarcoma (the name is well chosen : thii^, wliich e((uals caro or our word Jfish, means commonlv any soft animal substance, not blood nor bone). Thus it follows that there are several kinds of sarcoma, according to the tissues from which they are developed. The principal of Fig. 43. Lai-ge Trabecular Spindle -cell Spin file rell jicutly cross cut ^ Giant -cell orMyeloid Fibro Traiecular /(y\^/r^ >/ croKS-cut at -J- Sarcoma VJ / L/^ ^ff^ Glw Sarcoma -• 9 orifwi[li mucous Intercellular Mys-U Sarcoma Small Round Cell or Ly7nj)ho Sarcoma these are seen in the above schematic figure. The round-celled kinds generally arise from lymph gland or neuroglia or mucous tissue ; hence they are common in myxo- or glio- or lympho-sarcoma. The spindle-celled kinds arise from connective, fibrous, or bony tissue, and hence are most common in fibro-sarcoma or osteo-sarcoma. One other form of sarcoma is usually described, the alveolar sarcoma, which is not mentioned here. It is a rare form of tumor, and resembles superficially a cancer or car- cinoma. It is formed of a stroma, which maps out large spaces, and these are filled with large round cells. By careful pencilling the characteristic intercellular substance may be distinguished. MYXOMA. The name " myxoma" is given to all tumors of connective-tissue type (not epithelial) which contain mucus or mucin in their intercellular matter. It corresponds nearly to gelatinous sarcoma, collonema. and fibro-cellular tumor of old authors ; tlie forms of the cells are very variable, but in the most typical examples, and especially in the older and fully developed parts, the cells are large and usually multipolar or '' stellate." with a dis- tinct nucleus and nucleolus : the stellate branching rays of the cells are mutually con- 152 MYXOMA. nected. so as to form a more or less open network, in the interstices of which the mucous semi-fluid lodges. Beams and bands, which generally have a stiff, rigid appearance and an angular rather than a wavy disposition, pass about, dividing up the substance of the tumor into very imperfectly defined sections more or less visible to the naked eye ; from Fig. 44. Myxomatous EncJumdroma Stellate-cell Myj.vma '^^ LeijiTma SruhondwmcK Eound cell Myxoma Spindle cell Myxoma these arise fine fibrils continuous with the cellulo-fibrillar network. Much of the tumor. and especially the younger part, may be found formed of spindle-cells : these are really connected, by threads from their sides, with the intermediate fibrillar network, and it can often be seen that the stellate forms are produced by the drawing out of these threads to greater lengths, through the .separation of the texture elements by the increasing quan- tity of mucus. In yet other examples or parts the prevailing form of the cells is round or with one pole : the round cells resemble ordinary mucous corpuscles and are scattered among the fibrils in the mucoid matter : they also contain many fat-grains and are found in the oldest part? of the tumor, representing the senescence of its cells. There is also a great variability of the intercellular sub.stance — first, in proportion of the fibrous to the cellular part ; and second, in the proportion which these solid elements bear to the mucoid interstitial matter : thus, there is a fibrous myxoma and a clear pellucid variety, with much mucous fluid, pierhaps even forming cysts (hyaline and cystic myxoma). In some examples there are large polynucleated cells identical with the so-called giant cells of " giant-cell " sarcoma. In the theory of types, myxoma is affiliated to certain natural tissues, in particular the jelly of the umbilical cord, the vitreous of the eye at a stage of its development, and the early stages of adipose tissue, or to a stage of bone formation out of cartilage. It will be seen that these typical tissues are onlv transitory in their nature as compared with .such stable tissues as bone, cartilage, tendon. In accordance with this instability of their type, myxomas themselves .show many transitions to various kinds of connective tissue : these transitions are chiefly toward cartilage or fat (myxomatous enchondroma. myxomatous lipoma). Tumors are not infrequent, especially in the parotid region, which are intermediate between cartilage and mucous tissue, .so that one cannot say to which they most properly belong ; also many fatty tumors .show clear gelatinous patches of mucous tissue in all transitions to fat, while many myxomata .show opaque spots composed of true adipose tissue. rARflXOMA. The term •• carcinoma" is now distinctively applied to such tumors as have a structure of the following description — viz., a mcshwork of fibrous or sarcous substance compo.sing an alveolar structure, whose interstices are filled with cells. These may have no orderly or methodical-looking arrangement, being packed in the crevices in the mcshwork (or alveoli, as they are called^ and extending casually from alveolus to alveolus, so as to C'J/.v7.Vo.i/.|. 153 luake a oumpleuu'iitary iiu'sliwork. TIk- carciiH.niatous cliaracter in determined Vjy the presence dl" sueli alveolar structure with cell ciilleeti(»iis lodjred in it; the decisive point consists in these cells lyinj; dose toj^ether without any intercellular suhstance ; the cells generally vary in shape and have larj^e nuclei, with lar^rc and britromaf Lefl edye, drve/op -' of l/iis ialo a spi/idie cell Slrai/ia Hard Carcinoma (pleura S(cy lu breast. I he oldest part at I his end) FipilAe/ioma or uilhelial CarcC- Cy/t rider - £/iillielieil Ce/r, iiioiiut I'coluii, tt ^ sinit/tirstrito [^ t:urrjFiiiiJid in li'ver fif same casrj I ma ^shtfi of ':, e/r sk/>u i/iy /land-like si rielure resemS- liny a/so t/ie lym - ' phaltc ducts, several dirds Pfsl todies are seen I lie slrvma it of coi/ntcltve lis- siie ^ tiiphlu clierr- aid with T/ciiiQ • cells.) -^ ^ £/iithelioniei , or K/iilheliiil Curcitio/iKt SfitMioma or Epithrlial CarnTuma Separate Cells Microscopical Anatomy of Carcinoma. continuity with adenomas ; they differ from these chiefly in their history, as being infec- tious, so as to extend into the neighboring tissues, to the glands, or to the viscera, the structure showing only those minor peculiarities which I have just described. Five leading types of carcinoma may at present be conveniently distingui.shed : 1st. Those in which the fibrous meshwork is in preponderance and the epithelioid con- tents of the alveoli arc scanty, and perhaps also prone to perish early, so that they are found more or less degenerate within the fibrous meshes : Hard Carcinoma, or Scirrhus. 2d. Those in which the fibrous meshwork is in smaller proportion and the epithelioid 154 CARCINOMA. contents are plentiful, making large collections of cells, but with no evident approach in the form of these collections to the shapes of gland acini, and no evident resemblance of the component cells either to the columnar epithelium of mucous glands or the squamous epithelium of cuticle : Soft Carcinoma. This kind occurs especially in glands, and the transformation of the glandular tubes or follicles to cancer alveoli can be seen in all stages in the growing margin of the tumor. (See the two upper drawings in Fig. 45, from the liver and kidney.) '3d. A structure essentially such as that last described, but with this difference — that the epithelioid cells have a quantity of mucus between them, which is regarded as arising from a transformation of them. This change to mucus may be carried to such an extreme that scarcely any cellular elements are left, while the alveolar meshes in which the mucus is contained become very strikingly visible from their nakedness and the pellu- cidity of the mucus : Colloid, or Alveolar Cancer. A common seat of this is the wall of the alimentary canal, where it may be traced arising from Lieberkiihn's follicles. 4th. A structure in which the epithelial cells resemble squamous epithelium and form masses which are very like the follicles of cutaneous glands, or occasionally like rudiment- ary hairs ; the tubular and bulbous forms may, however, be seen ramifying like the lymphatic vessels of the skin, as if their form were moulded to the lymphatic plexus : Epithelioma. In these cancers peculiar bodies are. found, composed of flattened cells disposed concentrically so as to form a scaly-walled globe (a, Fig. 45) who.se appearance is like the section of an onion or like a bird's nest ; these are so large as often to be vis- ible to the naked eye ; when they are numerous and well characterized, they are diag- nostic. Some authors (Billroth) distinguished a variety of this cancer in which the stroma preponderates over the epithelial part, calling it scirrhus of the skin : Squamous p]pithelial Carcinoma. 5th. A structure in which the epithelial cells resemble ordinary columnar epithelium, and the structure itself is quite like normal mucous membrane, in which it always pri- marily arises (alimentary canal, especially colon, uterus) ; the secondary formations which occasionally occur in these cases, in the liver especially, have the same .structure, and thus a tissue like the glandular mucous membrane of the colon may be found in the liver : Cylindrical Epithelial Carcinoma. The fourth and fifth varieties are distinguished from the three first as epithelial can- cers or epitheliomata. Some authors have used the term " cancroid '" for the fourth variety, as though it were not completely cancerous. These are less likely to infect the viscera than the first two varieties, which are the most infectious of all tumors, though they are very far from being the only kinds of infectious tumors. YiRCHOW, 7)/e Krankhaften Gesehwuhte, 1862— 5. — Paget, Surylcal Padiolotjii, 1870. — Abkrnethy, On Tumors. — Pathological Societi/ Trans. — WiLKS and Moxon, Pathology.— Bu.i.B.OTii, Eteviens de Pathologie Chirurgicale, 1868. — Holmes, System of Surgery, 1882. — Debate on Cancer of Pathological Society, 1874. SURGERY OF THE CUTANEOL.S ^V.STEM. CHAPTER IV. CONTUSIONS. A "contusion" is an injury, caused either by a fall, a blow from a blunt instru- ment, or sevtMv pressure, in which there is no .solution of continuity of the skin. The degree of injury depends upon the amount of force a])])licd and the re.sisting power of the tissues injured. Ilealthy tis.sues .suffer little where the soft or unhealthy suffer much. The subjects of hioniophilia fare worse than all others. When the force has been suf- ficient to produce rupture of the small vessels in the skin and subcutaneous tissue, an " ecrlii/niosiV or " hniixe" is said to exist; when it so injures the deeper tissues a.s to cause effusions of blood from rupture of some of the larger vessels, '• fxtravasation of hloo(V' is said to be present ; when the blood effused fijrms a local swelling, it is known as a " hir.mntunKi.' After a slight contusion there may be no luuising. but only local pain and swelling, the swelling becoming red and then disappearing. The wheal that rises after a lash with a whip is the best illustration of this condition. An ** ecchymosis" is an effusion of blood iato the skin and subcutaneous tissue, and it shows itself, according to the force employed and depth of tissue injured, within a few minutes or hours of the injury, as a livid red, deep-blue, or black patch, which in the course of twelve or eighteen hours becomes larger and lighter at its margins. About the third day it assumes a violet tint ; on the fifth, an olive brown ; on the sixth, a green ; on the seventh or eighth it has a yellow aspect, and this, fading into a lemon tint, then disappears altogether. An ordinary bruise generally runs through all the.se stages in about two weeks, the rapidity of the process depending much upon the amount of blood effused and the reparative power of the patient. When no blood has been effu.sed into the skin, but '■ extravasation" has taken place in the deeper parts beneath a dense fascia, the discoloration of the integuments may not appear for three, four, or even fourteen, days, while in some cases, where the blood has made its way between the tissues and reached the skin away from the seat of injury, the "ecchymosis" will be at some distance from the spot at which the injury was received and may not show till late. When much effused blood exists, the swelling will be great. The (tbstiicf of ecchymosis is no proof that a contusion ha.s not been experienced, since a fatal rupture of deep parts or of some viscus may be present without any external signs of injury. On making a section of a bruised part the skin will be found throughout its thickness infiltrated with' blood and firmer and thicker than natural : whereas, when the effusion has been the result o? violence applied to the body after death, the blood will be beneath or upon, but not in, the cutis, and it will be in small quantities and venous. Neither />(/;y)»/v'(' putclii't^ nor those o^ ''' erj/thema ^lodosuni' ought to be ni'staken for bruises. The general diffusion of the spots over the body in the one case, and the history and the general aspect of the other affection, should prevent the error. It should be remembered, however, that in purpuric patients and in '• bleeders" a slight blow or pinch may be followed by a severe bruise. A severe contusion may cau.se a rupture of a large artery or vein, under which circumstances a fatal extravasation may ensue ; or it may so crush or pulp the tissues as to destroy their vitality : this a spent cannon-ball may accompli.sh ; or it may so rup- ture a viscus as to cause death. More frequently, however, a severe contusion causes a separation of the skin from the deep "tascia and deeper parts, with more or less extravasa- 155 156 ARROW WOUNDS. tion of blood into the split tissues. The effects of a contusion also vary according to locality ; thus, in an adult, a blow over the scalp may be followed by a local effusion of blood, and in a child this effusion may go on so as to form a swelling involving more or less of the whole vertex. In the buttocks and loins blood may be so effused as to give rise to a large fluctuating tumor. In the loose cellular tissue of the scrotum or female genitals an effusion of blood may give rise to enormous enlargement, and in the eye every one is familiar with the change. Where the extravasation of blood has been extensive, the removal of the clot is a work of time. In some cases the blood remains fluid for a long period, and at length becomes absorbed ; in others it breaks down and gives rise to suppuration. In some, again, it persists for weeks as a large blood tumor, and then suddenly softens down and is absorbed. In exceptional instances it becomes apparently encysted ; and " there is sufficient reason to believe," says Paget, " that blood extravasated in a contusion may be organized, acquiring the character of connective tissue, becoming vascular, and taking part in the repair of the injured tissues," as is seen in the repair of fractures and in liga- tured or twisted vessels. Treatment. — A slight bruise, if left alone and not manipulated, will get well ; for blood is often rapidly absorbed, as is seen in the eye. To check extravasation, cold is the best application, in the form of pounded ice in a bag, or a mixture of salt and saltpetre, or the iced poultice,' or, what is far better, Leiter's metallic coil (Fig. 9, p. 49), and in an extremity elevation of the limb with rest. To check any inflammatory action during the progress of the case cold is equally effective. To hasten the absorption of the effused blood tonics are often of service, and the application of gentle pressure by means of bandages or strappings is valuable. A lotion of the tincture of arnica one ounce to a pint of water, or one of the stimu- lating liniments, such as the soap or opium, seems to have some influence in hastening the absorption of blood. In cases in which there is extensive effusion of blood, and where the circulation in the part is interfered with, lint soaked in oil and covered with cotton-wool is the best dressing to maintain warmth in the part ; moist applications are not good. When the blood remains fluid and is not absorbed, the surgeon need be in no hurry to interfere, for occasionally interference brings trouble, although, when time pres,ses, the use of the "aspirator" to draw off' the blood — or, rather, bloody serum — often expedites recovery. AVhen aspiration has proved ineffectual and a blood-clot remains, this should be evacuated by a free incision, and the exposed cavity irrigated with iodine, boracic acid, or carbolic lotion and then drained, well-applied pressure and immobility of the part being employed. When the blood has broken up and suppuration appeared, a free incision is essential, the case subsequently being treated as an abscess. Arrow Wounds. These, which are punctured and incised wounds, have been made the subject of a special essay by Dr. Bill in the American Journ. of Med. Science, vol. xliv., 1862. He tells us that it is exceptional to meet with single wounds, the American Indians discharg- ing their arrows so rapidly — an expert delivering six in a minute — that if one takes effect it is immediately followed by others. The Washington Army Medical Museum contains specimens of penetrating arrow wounds of the skull. Where both tables are punctured there is little or no Assuring externally or internally, as the vitreous table is penetrated as cleanly as the outer. " This is in such marked contrast to the results of bayonet or sword thrusts, or of the impact of gunshot projectiles, as to merit notice." Arrow wounds of the chest are not always fatal ; those of the abdomen are generally so. Dr. Bill tells us that the Indians, on this account, always aim at the umbilicus, and that the Mexicans when fighting the Indians, on this account, always protect the abdomen. The velocity of the arrow when first projected is so great that it has been estimated '/ce poultices, as suggested by Maisonneiive, are excellent for tlie local application of cold, and are made as follows; Take of linseed meal a sufficient quantity to form a layer from three-quarters to an inch thick ; spread a clotii of proper size ; upon this, at intervals of an inch or more, place lumps of ice the size of a big marble; then sprinkle them over lightly with the meal, cover with another cloth, folding in the edges to prevent the escape of the mass, and apply the thick side to the surface of wound. The exclusion of air retards tlie melting of the ice, and the I hick layer intervening between it and the surface prevents painful or injiu-ious contact. In injuries to the abdomen this remedy is very applicable. Dr. W. H. Doughty of the U. 8. A. speaks highly of it. Circular No. 3. Ji[riL\S AM> SCALDS. 157 to etjiuil nearly that of a imiski't-liull, hut arrow-tirin;; is incfl't'ctive over a hundrcil yards. At a short distaiici' an arrow will pcrloratc tli»; larjji'r hones without conMniniitiiiL' them, or will Fio. ■!*). cause a slijjhl tis.sure only, reseinhlini:; in these JB respects the efieet of a pistol-hall Kred throu";!! ;i , ^^^ pane of i;lass a few yards off. This is well seen /' . . ^ in the drawing; (l'"'^- ■^^*)- \ ^^-"^^ ~ j The wound of entrance in the soft parts is a [ _ ^--^^^ ^^^''^^ - ■' contusetl depressed slit; tliat of exit, a mere slit. ., , „ , ,, . ~ \\ hen an arrow strikes tlu? skin ol>li(|uely, tlie (.surgeouGenfrara (jtlke, L. .s. <:iiL. ;.) wound will l)e that of a loiii; incised wound. The treatment of these wounds is thus summarized hy Dr. IJill ( Inti ruationnl Hniydo- j)tri/iit of' Siiiyrr//. vol. ii.): 1. \u arrow-head must he removed as s(jon as found. 2. in the seanli for the arrow e.vtensive incisions are justifiahle. 'A. All arrow may he j)ushed out as well as plucked out. 4. The tiiiLTcr should he used for e.\i)loratioii in preference to a probe. 5. (Ircat care must be taken to avoid detachment of the shaft. 6. Healing by tirst intention should be encouraged. BURNS AND SCALDS. A burn is caused by the ai>plicatioii of concentrated '//// heat to the body ; a SCald, by the application of hot or boiling li(|uid. As a rule, scalds are les.s .severe accidents than burns, because water, being the ordinary fluid through which the scald is produced, is never hotter than 212° Fahrenheit; yet when any other chemical compound is the scalding medium, the effects are, at least, often as bad as the worst burns. The worst local burn I ever saw was when a man put his booted foot and ankle into a pot of molten lead. Tiie limb came out covered with a boot of metal, and was destroyed even to the bones. Mr. Aston Key amputated the limb at once below the knee without removing the metal. A moderate degree of dry heat applied in the pursuit of a calling indurates the skin and blunts its sensibility, and an iron-worker or a blacksmith can maniijulate pieces of hot iron that would " burn " ordinary people. Thus, some .skins or parts of the body are more sensitive than others, and under the same influence may be differently affected. The effect of heat when applied to the body varies according to its intensity and the (hirnfion of its application ; it may cause a simple redness of the surface or the death of the part. Thus, its jirst effect is mere redness and tenderness of the surf^ice, and after a few hours the.se .symptoms may subside, the cuticle possibly desquamating. In the second (h'tjree of heat inflammation is the result, this action manifesting its pres- ence by the formation of a hiistcr, from the effusion of serum beneath the cuticle. In the third degree the superficial layer of the true skin is destroyed, the siir/nee appearinr/ of a graij-yeUoicish or hrorcn color, not painful unless roughly handled. The vesicles that exist contain a blood-stained or brown fluid. The papilla? of the skin, with its nerves, are first destroyed ; but when, in the course of a day or so, the dead surface has been -'shed" and the nerves exposed, the pain is very severe and the exposed surface has a reticulated surface. In the /our f/i degree the whole thickness of skin is destroyed, with more or less of the subcutaneous cellular tissue, the parts being converted into a hard, tough, dry. and insensi- ble eschar mottled with blood : vesication does not exist in this degree, all the superficial tissues having been destroyed. The skin surrounding the eschar may be blistered, but where it comes in contact with the injured part it will ])e drawn into folds from the con- traction, owing to the drying of the burnt integument ; this puckering fairly indicates the important fact that the whole skin has been destroyed. The eschar does not begin to separate fur four or five davs, an inflammatorv zone of redness with pain of some sever- ity indicating the commencement of a process that will not be completed for two or three weeks. When the slough has come away, a long and tedious process of suppuration and granulation must be gone through prior to the repair of the exposed parts. In the Jj/th degree the skin with the deeper parts is involved, a black, brittle, charred mass taking the place of healthy tissues. In the sixth degree the whole thickness of a limb is carbonized. These divisions, originally made by the great French surgeon Dupuytren, .so well 158 BURNS AND SCALDS. accord with all observation that they have been invariably adopted by modern surgeons ; and, although in burns and scalds one degree passes imperceptibly into another and in bad cases coexist, in the main they can be made out. Prognosis. — Next to the intensity of the heat and duration of its application, the extent of surf ace involved is the most important point; indeed, as regards life, it is of far greater importance than the other two, because a superficial burn spread over a large sur- face, although not locally so injurious as a more severe one, is more fatal. In the major- ity of cases of deaths from burns and scalds, more particularly in children, the ri.sk to life is fairly to be measured by the extent of surface involved ; when more than half the body is injured, a fatal result generally ensues. A severe burn of a limited character may be, however, only a local affection. Thus, the danger to life turns upon many points. In both young and old all burns or scalds of any extent are serious. At any age extensive burns, however superficial, are to be feared, and they become serious from their immediate depressing effect upon the system ; patients sometimes die from shock, and the very bad cases are marked by the sensation of coldness and persistent shivering. When the period of shock — which varies from twelve to forty-eight hours — has passed, and that of reaction has set in, other dan- gers appear. Should the injury be over the thoracic cavity, chest complications may be looked for ; and if over the abdomen, intestinal and peritoneal troubles. Burns and scalds of the head are not so likely to be followed by intracranial as those of the chest are by thoracic mischief. All intestinal complications should be carefully observed, as there seems to be a liability to irritation of the inte.stinal mucous tract, which may terminate at times in ulceration. Dupuytren first observed this in a general way, but Long (Lond. Med. Gaz., 1840) and Curling (Med.-Chitr. Trans., \o\. xxv., 1842) showed that ulceratioi. of the duodenum, as proved by inspection after death, and indicated during life by vomit- ing and purging of blood, is by no means an unfrequent result. Out of 125 fatal cases collected by Holmes and Erichsen, 16 presented ulceration iii the duodenum, of which 5 died during the first week and 5 in the second, the situation of the burn in all but two being on the chest or abdomen. " The ulcer always has an indolent aspect and is situated below the pylorus ; often there are two or three close together ; the edges of the ulcers are neither raised nor everted ; there is little or xuo evi- dence of inflammatory effusion in their neighborhood ; w^hen they ai-e recently formed, they look simply as if a pjortion of the mucous membrane had been cut out ; but when the ulcer has penetrated more deeply, so as to threaten perforation of the gut, lymph may often be found effused on its peritoneal surface. Sometimes the glands of the duodenum may be found enlarged "' (Holmes). The symptoms of duodenal ulceration are most obscure, as neither pain nor tender- ness exists ; diarrha?a is neither constant nor excessive ; vomiting is perhaps a more com- mon symptom ; and the presence of blood in the motions is highly su.spicious. When the ulcer has perforated the intestine, intense pain, vomiting of blood, melrena, collapse, and abdominal distension mark the fact. It should be noted that cicatrized duodenal ulcers have been found in patients who have died of other complications. Casting Off of Sloughs. — In the second or injiamm atari/ stage the injured parts are being thrown off, and most writers allow for this process about fourteen days, though in some cases it is less and in others more. When, however, the slough has separated and the parts begin to suppurate, the third stage, or that of suppuration, has commenced. In this stage, although there may be less probability of visceral complications appearing, there is the equally great danger of exhaustion, hectic, or pyaemia, Should these risks have been surmounted, there is yet the long and tedious process of the healing of the granulating surface, and at a still later period evils arise connected with the gradual con- traction of the cicatricial tissue. This contraction only takes place when the tcholc skin has been destroyed. When the surface of the skin merely has been involved, and not its depth, the sore, on the removal of the slough, has a peculiar net-like appearance, with a whitish or yellowish ground, through the meshes of which granulations project. Cause of Death. — When a person dies from a burn within forty-eight hours, it arises from shock or collapse, pain doubtless having its full influence ; when a similar result takes place during either the stage of reaction or of inflammation, it is from vi.s- ceral complication ; and when during the third or suppurative stage, from exhaustion, visceral changes, or pya>mia. When a person is said to have been "burnt to death," he dies from suffocation, the fumes of the fire destroying by asphyxia, and the fire subsequently burning the body. BURNS AM) .SCALDS. 159 II:iH' tho oases of burn aihniltiil intu a hospital y lif^htniiij^ arc burns, criipiiims of crvtlieiim or urticariu, loss of hair over parts or the whole of the body, woiimls, heiiiorrhafre from the mouth, nose, or ears, loss of sight, smell, spciech, hearing, and taste, or, in rare eases, exaltation of tliese special senses, eataract, imliccility. or abortion. It somotina-s k-aves arbonisccnt marks on the body, even on parts eoveri'd liy elotlics, which have (iftcn bccdi (htseribed as a kind of jdiotograph of neighboring trees or (»ther subjects. Persons not killed on the; spot usually recover, thougli some die from exhaustion ; recovery can be hastc^ned by tonic treatment, and galvanism is l»enelieial in paralysis. liurns caused by lightning are deep and obstinate; sometimes, however, they arc mere vesications and should be treated as other burns. In Wilks's ease the man was thrown down and strij)pecst treated l>y hjcal stimuhmts, such as iodine or l)listerin,u Hiiid. the ohject heinu: to l>reaii up hy some h)cal inHaniuialory process the hiwlv-nriraiii/.ed tihrmis productinn. Cheloid tumors uniw as indurated smooth tiihendes, at first havinj; a red or pinkish cohir, but as they increase Itecouiing pale. Tliey arc at times painful — or. at least, irritable — and rarely attain a larue size. They had better be left alone, for they are apt to return in the cieatri.\ formed after their removal. Cheloid tunujrs , •• , and Contracted Evelid. nerve, in a case 1 had .some years ago the external popliteal nerve, as it wound round the head of the fibula, was so bound down by the cicatrix of a burn as to cause severe agony in the whole course of its distribution. The sj'mptoma were relieved by two free vertical incisions through the cicatrix, and the patient recovered. 164 OX SKIX-GEAFTIXG. Should I ever see a similar case. I shall pursue the same course, except that I shall sub- sequently transplant pieces of skin in the wounds as soon as they assume a healthy appear- ance. When the pain is due to an adherent or bulbous nerve, the nerve must be freed and removed. When doubt as to its condition exists, Mr. Hancock's suggestion may be adopted, to divide subcutaneously the suspected nerve. Where no such causes as have been men- tioned are to be made out, the case may be treated as one of neuralgia by full doses of qixinine. arsenic, or iron, and local sedatives (the extract of stramonium or belladonna rubbed down with glycerine being a good application). Cases, however, of painful stump? or cicatrices are sometimes met with that defy treatment. Congenital cicatrices are met with in practice. Thus, I have seen four patients, all females, with cicatrices in their upper lips, as if they had been operated upon for harelip (Fig. 52 was taken from one of them, and Fig. 188, Chapter XII., from another). In the former there was likewise a fissure of the nostril and a narrowing of the fissure of the eye. Bridles connecting the lip with the gum in an unusual manner are not uncommon. ON SKIN-GRAFTINa. When John Hunter, a century ago, succeeded in transplanting the spur of a young chicken from its leg to its comb, as well as into the comb of a second bird, and found that it not only lived, but grew, he probably never dreamt in any flight of his genius that the fact which he then established would be so applied in the practice of surgery as to mark an era in its progress, and to bring a class of cases which surgeons were apt to look upon with little interest amongst the most curable and tractable of local aifections. And yet this has come to pass, M. Reverdin of Geneva, on October IG, 1869. having suc- ceeded in transplanting small portions of skin taken from one part of a mans bod}' to the granulating surface of a large sore, under which treatment the ulcer healed. He read the case before the Surgical Society of Paris on December 15, 1869, and asked. " Is the growth of skin due to the effect of contact or neighborhood, or is it due to proliferation of the transplanted elements?"' Mr. G. D. Pollock of St. George's Hospital, encouraged by M. Reverdin's success, followed up tlie practice, and the good results he and his colleagues obtained soon induced all other surgeons to follow in their wake. The facts can be read in the Transact ions of the O'tnical Society for 1871, and at the present moment it may now be considered as a well-established practice. Since its introduction I have very extensively carried it out. and in most instances with success. I look upon the suggesrion as very valuable, its adoption rendering many cases curable that were not so previously, facilitating the cure of as many more, and giv- ing interest to a class of patients in whom formerly there was but little. In the manage- ment of healing ulcers it is a great boon, while in the treatment of the large granulating sur- faces so common after extensive burns its value cannot be overestimated. As an adjuvant to many plastic operations, more particularly on the face and in the case of deformities, it is invaluable. Under the action originated by the transplanted fragments of skin, a process of repair goes on which at first appears almost magical : the grafts soon become islets of skin, round which cicatrization proceeds; the margin of the sore receives an impulse in cica- trization, which rapidly extends ; and between the grafts themselves and the margin of the sore connecting links of new skin rapidly form, which divide the sore into sections (Figs. 53 and 54). ' By these means large surfaces speedily cicatrize which under former circumstances would have required many months. Moreover, the contractions and subsequent deformities that under other conditions were too well known to follow in such cases do not occur. The practice seems applicable wherever a large granulating surface exists, and in its adoption the only desirable point to observe is that the mrface of the sore should he healthy. This clinical fact includes another — that the patient's health is good, for there is no better barometer of health than a sore, its surface assuming a healthy or unhealthy appearance with every alteration in the general condition of the body. I have attempted, however, by way of experiment, to graft skin upon sores that were not quite healthy, and have sometimes succeeded. In some indolent sores in which a small patch of healthy granulations sprang up I have succeeded in securing by tran.splanting a new centre of " cutification,'' which proved of great value in aiding the healing process ; in some others the graft has been enough to excite a more healthy action in the sore ; still, in many, poor success followed the practice. It may, therefore, be accepted as a truth that a O.V SKIS-CllAlTISa. 1 0.5 hcitUhji rfritintlnttii'i siirfarr is iiii unjinrldiit, iiIiIkiiiijIi not an essnitinl, rrtjiu'siff f'i,r siiccesn in shin-c' ])L'rfort and pnttection to the part. For this purpose there is nothing better than to bind on a piece of sheet-lead over the cicatri.x when the seat of mischief is on the leg, as by it equal pressure as well as protection is afionU'd. The new skin soon becomes as sensitive as the old ; the sensibility of the cicatrix under these circunjstances, indeed, seems to be greater than when unaided cicatrization is allowed to take place. Sponge Grafting. Dr. Hamilton of Edinburgh introduced this practice into surgery with a view of expediting the repair of deep wounds in which much loss of tissue has taken place, and he did so " thinking that sponge would imitate the interstices of the fibrinous network in a blood clot or in fibrinous lymph, '' and that the blood vessels of the new surrounding tissues would push into these interstices and grow, and so fill up the cavity, the sponge eventually becoming absorbed. He gave cases which were apparently successful, and many have been recorded since. To carry out the practice, a fine section of sponge should be applied to a healthy granulating surface and the sponge covered with oil silk. A layer of lint saturated with carbolic or terebene oil should then be applied, and the whole wrapped in some antiseptic gauze or boraeic or salicylic wool. The dressing should be removed every second or third day, according to the quantity of discharge. The sponge is prepared by being steeped in diluted nitro-muriatic acid, to dissolve the silicious and calcareous salts, and later on washed in a solution of ammonia or potash, to remove all excess of acid. Before being applied it is purified by prolonged treatment with a five-per-cent. solution of carbolic acid. In the original paper Hamilton recommended thick sections of sponge; he now u.ses fine ones, fresh layers being con.secutively applied as granulation tissue grows. I have employed sponge grafts on many occasions, and have seen more cases in which the prac- tice has been carried out ; and I can testify to the fact that the sponge becomes as it were incorporated with the granulation tissues, but whether it really expedites repair or not, or becomes of any practical value in the repair of deep wounds. I am not prepared to say. Chilblains. Chilblains are local inflammations of the skin, and are to be met with in subjects of a feeble circulation. They are more common in the young, and in women than in men, are generally seen on the toes, fingers, nose, or ears, and are caused by any sudden change of temperature or any sudden application of cold or warmth. They show themselves as simple congestions of the skin attended with tenderness or itching; vesication of the skin, when the inflammation is more severe', or .sloughing arid ulceration of the skin, when a broken chilblain occurs. The disease may begin and stop at the first or congestive stage or run through all the stages. Toward evening the symptoms of irritation are always increased, and any external warmth, as of a fire or bed. any full diet or stimulating drink, aggravates them : in fact, anything that excites the circulation in the part, at any hour of the day or night, is apt to increase the symptoms. Tre.\tment. — The local treatment of chilblains is no less important than the general, and more successful ; for, whilst tonics, good diet, external warmth, and exercise are neces- sary to improve the general powers of the patient and the circulation, local stimulants are of great value. When the chilblain is not broken, the local application of the tinc- ture of iodine, of a solution of sulphate of copper (three grains to the ounce), of camphor liniment, of soap liniment with opium or one-fourth part of the tincture of cantharides, of compound tincture of benzoin, or of simple spirit, not only gives comfort, but hastens the cure of the disease. The parts should also be covered with strapping spread on leather. When the parts are broken, vaseline, boracic-acid ointment, with the use of thick lint ' Edinburgh Med. Joiirn., Nov., 1881. 168 FROSTBITE. and oil silk or elastic tissue, are tlie safest remedies, stimulating lotions being used later when the parts are indolent in healing, such as terebene and oil or carbolic oil with opium. Warm socks and loose shoes or boots are always indicated, but anything like pressure is most detrimental. Exercise also should be taken when possible, and an equable tem- perature ought to be maintained. Frostbite. It has already been shown that the sudden application of cold to any exposed part of the body of a feeble or depressed subject is liable to be followed by '■'■ chilhlahi ;^' and when concentrated cold is applied, under these circumstances, for a period sufficient to arrest the circulation in a part, a ^^ frostbite^' is the result. Sudden and severe alterna- tions of heat and cold under exposure, even in healthy subjects, may produce this result ; in military life this fact is well known. The first eifect of cold upon a part is a sense of numbness and weight with a feeling of tingling. To the eye the skin will probably appear redder than usual ; and if the part be removed from the influence of the cold at this time, recovery, or in feeble subjects a superficial '• chilblain," may follow. If the cold, however, be allowed to act longer, the parts will become stiif, and at last insensible, feeling '' dead." To the eye they will assume a white and waxy aspect and be senseless to all impressions, the blood having been completely driven from the surface. When the cold has been suddenly applied and is sufficient to kill the structure outright, the frozen part will have a mottled aspect, from the retention of blood within the tissues. Many of these effects may be produced by the aether spray. The constitutional effrcti^ of cold are at first stimulating, and subsequently depres.sing, excitement passing into sleepiness, and this into torpor. If the latter be yielded to, the sleep will end in death, the blood being sent from the surface of the body to the brain and other viscera, and death being produced by blood engorgement, as in apoplexy. In the " sleepy and depressed stage " of cold, if the patient be brought suddenly under the influence of warmth and placed too near a fire, the risks of lung engorgement, as well as of rapid gangrene of the frozen parts, are very great ; for by sudden reaction the arte- rial circulation becomes quickened when the parts gorged with blood have lost their power of propelling onward. In gangrene from frostbites there seems reason to believe that ulceration of the duodenum may follow, as after burns. Mr. Adams has recorded such a case in the American Med. Times, for 18G3. Treat.ment. — Any sudden alternation of temperature being most injurious, the aim of the surgeon should be to recall the affected parts fjrinJnally to their normal condition — firstly, by assisting the venous circulation by gentle friction in the course of the veins with furs or flannel ; and secondly, the arterial by comparative warmth applied externally and gentle stimulants administered internally. Neither warm water nor air nor fire should be allowed to approach the parts until the natural temperature has been partially restored, and then only with great care. Friction with snow or iced water is most useful. On reaction, the parts may be raised and lightly covered with flannel or cotton-wool or exposed to the warm air of a chamber ; whilst food and stimulating drinks are carefully administered, warm milk with a little brandy being the best. Should reaction be too severe, it must be checked by lead or spirit lotions. When gangrene follows — and it mostly does when the third degree of freezing, or the mottling stage, has been reached — and only small portions of the body suffer, such as the integument, the parts may be dressed by some stimulating application to hasten the sepa- ration of the slough, and should be kept warm. Carbolic acid and oil are probably the best applications; tonics should also be given. When large portions of the body suffer, such as the whole foot (and in this country I have seen a coachman who had on new tight boots on a bitter winter day lose both feet), amputation may be called for, the surgeon always waiting till the line of demarcation or limit to the sloughing process is fairly marked. Boils. Boils are, in a measure, allied to carbuncles, and both are due to inflammation of the skin and subcutaneous tissue, though the disease probably commences in the latter. In both there is effusion of lymph into the areolar tissue of "the part, and in both this gene- rally sloughs, although in the boil the slough is local and confined to one central point, BOILS. 169 whilo ill rarhiinclo tlio process may cover an extent of integument varying from the size of half a eniwn to that of a phite. Boils are met with in two forms — '<»'■ as a subcutaneous affection atten or cheek gives way. It is associated, like carbuncle, with great constitutional de|)ression, and its special danger is thrombosis ami phleltitis of the c^t may be treated in the same way when not too extensive. When, however, they are extensive, they may be made to dry up by the application of some powder, such as the oxide of zinc, or even starch. Powdered fresh savine is a good application ; Mr. T. Smith recommends it to be mixed with the powdered diacetate of copper. The perchloride of iron in tincture is also serviceable. Venereal warts and others, when extensive, may be readily destroyed by means of the galvanic cautery, the patient being under chloroform. At times excision is the best practice. In the large masses that are found on the genital organs of women, of venereal origin, nothing but the removal of the whole with the labium can be entertained ; when the ecraseur of the galvanic cautery cannot be obtained, the ordinary wire instrument may be used. The hemorrhage from these venereal warts is generally severe, and the surgeon should never attempt to remove them by excision, when they are exten.sive, without having at hand some good styptic, such as the solution of the perchloride of iron, matico, alum dry and in solution, or the cautery in one of its forms. Moles. Using the word in the broad sense to include .«mall spots of discolored skin, and cutaneous connective-tissue tumors with pigment, with or without unnatural growth of hair or skin glands, they are very common, few people being without one or more upon the surface of the body, while many have them in numbers. I have seen a woman studded all over with hairy moles, the hairs having been in some half an inch long and bi-istly. Moles are generally congenital, but at times put in an appearance later in life ; they are rarely of any great importance beyond the disfigurement they produce. Occa- sionally, however, they degenerate or become the seat of a cancerous disease; the mela- notic sarcoma has frequently its origin in such congenital spots. This clinical fact, which is now fairly recognized, is important, and renders it expedient for the surgeon to excise any mole that has a tendency to grow or to become indurated in middle life. Many of the most virulent forms of multiple cancer the surgeon sees have their origin in moles. Corns. These are thickened cuticle, the result of occasional pressure, whether on the toes or feet, from tight or hard boots, or on the hands, from the mechanical irritation of tools, etc., 174 BUNIONS. or elsewhere. It should be remembered that they are the result of occasional, and not constant, pressure, the latter causing atrophy and absorption. " Not only," wrote Hunter, " the cuticle thickens, but the parts underneath ; and a sacculus (bursa) is often formed at the root of the great toe, between the cutis and ligaments of the joint, to guard the ligaments below.'' This bursa is found under all corns when the pressure is not removed. A corn, when newly formed, can by maceration be elevated from its position as thickened cuticle only, the cutis being unaffected ; but in old corns the cutis appears to atrophy and the papillce to disappear. Such corns, writes Mr. T. Smith (^Holmes's St/st., vol. v.), " may be found based upon the fibrous tissue of the sheaths of the extensor tendons of the toes, all intermediate structures having been absorbed." When a bursa has formed, it may inflame or suppurate and give rise to troublesome conditions such as will be described under " Bunion." A corn is called " soft" when it forms between the toes. It is far more painful and sen- sitive than the '' hard ;" it grows also more rapidly, probably owing to its greater moisture. Treatment. — Remove the cause and the disease will disappear. This is a doctrine which applies to corns of all forms when acted upon early. Boots which are too loose are as injurious as those which are too tight : where one presses the other rubs, the result being the same. A well-fitting boot with a broad sole, straight inner border^ and square top is the best. To remove the cuticle nothing equals warm water ; and after soaking the part in it for some time, or keeping the corn covered for a night or more with water dressing and oiled silk, the whole may be carefully peeled off by means of a knife. After the removal of the corn the skin should be protected by a piece of soap plaster spread on leather. The application of nitrate of silver has been recommended, but I have known it produce great pain, and when applied to an inflamed corn much harm — indeed, in one case, sloughing of part of the integuments covering the little toe. In old people it is dangerous. The application of the glacial acetic acid is to be preferred. When suppuration takes place beneath a corn, it should be relieved by a puncture as soon as possible, and water dressing applied. Bursal swellings are to be treated as bunions. Soft corns are best treated by taking away pressure by means of the introduction between the toes of absorbent cotton-wool and the use of some dry powder, such as the oxide of zinc ; the corn thus soon becomes a dry one and is easily eradicated. Acetic or carbolic acid is a good application in obstinate cases. Bunions. When from excessive or long-continued pressure a bursa forms over one of the tar- sal or metatarsal articulations, a " bunion " is said to be present ; and the most common seat for this affection is the metatarsal joint of the great or little toe. This fact is to be explained by the evil tendency which boots, as Fig. 58. Fig. 59. generally made, have to draw the toes together toward the central line of the foot, the central axis of the undeformed great toe, which runs parallel with the metatarsal bone through the centre of the heel, being thus made to deviate from the normal to an abnormal line, in which the great toe itself, looking outward, forms with the metatarsal bone at the joint an angle pointing inward, and the axis of the toe falls far within the normal one of the _ . foot (Fig. 58). BuniouT''"*'^ Toe-Ca^lb^ the Cure of Aston Key,' however, attributes this deformity Bunion. more to exces.sive weight received on a weak tarsus and metatarsus from over-standing, the great toe being gradually forced outward by the oblique bearing of the foot on its inner plantar surface when the arch of the foot has given and the foot becomes flat. Too short boots greatly favor this change, the foot by such being compressed longitudinally and the arch of the tarsus increased, the toes even being drawn up to form angles with the metatarsal bones, the great toe suffering the most. When bursae form over the projecting bones, it is to save the joints from injury ; and at times these form over the dorsum itself. Under extreme conditions the bursa may inflame and suppurate, giving rise to obstinate and troublesome sores. In still more extreme or neglected cases the joint of the great toe may be involved, ending in its destruction with or without exfoliation of bone. 1 Gtiy's Hosp. Rep., 1836. i.y-ajiowy tok-sml. ■ 176 TiiKATMKNT. — Wlipn tlip nuturt! of a luuiion is un/sf., vol. ii. p. 938, 3d edition). In the last stage, when the joint is destroyed, the case may have to be treated by incision of the parts, excision, or even amputation. In-Grown Toe-Nail. This is a troublesome and painful affection, and is more commonly met with on the outer side of the great toe-nail than on the inner, though it may occur in both places. It is usually caused by external pressure upon the soft parts, the movable soft parts being pressed upon the immovable nail. As often as not it is due to the collection of cuticle beneath the edge of the nail, this cuticle acting as a foreign body and by its pressure causing ulceration. Ulceration having once been set up. the healing process is prevented by the presence of this cuticle, together with the pressure of the edge of the nail and the soft parts covering it in ; fungous granulations, as a consequence, frequently form, and copious discharge takes place, the affection being attended with severe pain. Treatment. — The disease being the result of pressure applied from without in the shape of tight boots, or from within in the form of indurated cuticle beneath the nail, the surgeon's main object in the treatment is to take away the exciting cause, and when the collection of cuticle exists, by the careful introduction of a probe beneath the nail, to procure the evulsion of the foreign body. In the early stages of the disease this treat- ment is often sufficient. When external pressure has been the cause and ulceration exists, the soft parts may be carefully pressed away from the sharp edge of the nail by the careful introduction beneath the overhanging integument of a .small roll of lint, which should be well pressed down to the bottom of the sore and fixed in position by means of strapping, applied so as to draw the soft parts away from the nail. This treatment, by- removing all pressure from the sore, as a rule, is successful. When the fungous granula- tions are excessive and the discharge is profuse, the free use of the powdered nitrate of lead before the application of the lint is of great value. After one or two applications of the lint in the manner described, the soft parts will have been so pressed to one .side as to expose the edge of the nail with the surface of the .sore, when the lint or a piece of thin sheet lead or tinfoil may be introduced beneath the edge of the nail and the dressings renewed. By this treatment a rapid cure readily ensues; and if no external 176 ONYCHIA MALIGNA. Fig. 60. pressure be reapplied and the nail is allowed to grow up in its normal square form, there will be no recurrence. In severe cases, where the soft parts so overhang the nail as to be unaffected by the means here suggested, or where the nail perforates the soft parts (Fig. GO), the best course is to excise the overhanging integument by means of a scalpel ; the ulcer by this method is exposed, and the sore during the process of cicatrization so con- tracts as to draw the soft parts away from the nail, which will then grow up in its normal form and act as a covering to the toe. When the ulcer has spread far under the nail, it may be expedient to remove a portion of the latter to allow of cicatrization, though, in a general way, to remove half the nail, to take away a V-piece from the central part of its edge, to scrape or notch it, are only temporary remedies. They may succeed for a time and allow the sore to heal, but it is certain to recur in all severity as soon as nature has restored the parts which the sur- geon has removed. To cut the corner of the nail under the idea that it is the offending body is a futile proceeding ; it may for the moment appear to be of ser- vice, but in the end it is injui'ious. Indeed, the nail should be left square, as nature made it, and care should be taken to see that the soft parts are in no way pressed over its edge. Onychia Maligna. luvLludllKJIlOll ™, . . ,. „ , ., . in 11. Inis IS a disease oi the nail matrix, and a lar more severe and obsti- nate affection than the last. It is found most commonly in unhealthy children, and, as a rule, is started by some local injury, such as Fig. 61. Fig. 62. a squeeze. It commences as a swelling of the end of the toe or finger, with the other external signs of inflammation — redness, heat, and pain. These symptoms are soon followed by the exudation from beneath the nail of a serous and often fetid fluid ; the nail itself loosens, sometimes falls off, or either flattens out or curls up at its edges (Fig. 61). When this occurs, a foul ulcer is visible be- neath. In extreme cases the affected parts assume a flattened bulbous form and look as incurable as any local affection can well ap- pear, and in rare instances the disease in- volves the last phalangeal joint or bone. It is never found in other than feeble and ca- chectic children. The worst case of this nature I have seen occurred in a child ast. 10, in whom the fingers and thumbs of both hands were involved ; and the disease had existed for years. Treatment. — In favorable and not extreme examples of this affection tonics inter- nally and water dressing externally suffice to bring about a cure ; while in others more active local treatment is called for, such as the application of some mercurial lotion, as black-wash or Abernethy's lotion (formed of the liquor potassae arsenitis 3ij to Sj of water) or the red-oxide-of-mercury ointment. In the case to which I have already alluded all this treatment failed, even after the evulsion of the nails — a plan of treat- ment that should always be adopted in obstinate cases. The cure was at last effected by making a clean shave of the dorsal aspect of the extreme phalanx, taking away nail and soft parts. This course was resorted to only after the disease had existed for five or six years and had resisted every form of treatment, even to the repeated evulsion of the nails, the pain being agonizing and demanding surgical interference. Fig. 61 was taken from one of the fingers of this patient. Professor Vanzetti of Padua strongly advocates the application of the powdered nitrate of lead to the ulcer, and my own expe- rience of its value justifies me in strongly recommending it. Constitutional treatment, with tonic regimen, is always necessary. The disease may at times have a syphilitic origin, when it will be wise to adopt specific treatment. Acute Onychia. Chronic Onychia. ELEPHANTIASIS. 1 77 Other Diseases of the Nails. TIiultT the iiifliiciicr of sitiiic aciitc diseiisiis, the nails cease to n, Wilks, and Fair,u;e have fairly provtid that the nails may hecome narrow, thick, ill-fnrmed bodies, or concave, rough, and hiaek. Psoriasis att'ects the nails somewhat in the same; way. the nail thicktMiing and split- ting \ ertically ; and in fariis Fagge has shown that the nails may become thickened and of a yollow color from the interstitial deposit of the parasitic disease. Wilks in the Lancef for ' Fio. 63. Fig. 64. ISCS, and Fagge in Giu/s IIosj,. Rep., 18611-70, have written fully on these j)oints. At time.s \)^ the nails become .soft and in feeble subjects very oonve.x. This condition is .said to be com- mon in phthisical su])jects, but in .surgical dis- ease I have often observed the same condition appear during illness and disappear as strength returned. I regard it only as an evidence of feeble power. Horny growths occasionally spring up beneath the nail, as seen in Fig. 03, and ungual ^„^.-,4-^^;^ 1 • 1 ; „ u .,„ „,,* ,..4^k 4^',. ... Horuy Growth from beneath fngual Kxostosia. exostosis — which IS a bony outgrowth trom •' jj^jj ^ the extreme phalanx of the great or otlier toe — very frequently appears as seen in Fig. G4. Both require excision. ELEPHANTIASIS. This term has been applied to two very different diseases- — the Elephantiasis Grx- corinn, or true kjrrosy, and the E/epJtanfiasis Arahiim, or Cochin or Borhadoes hfj. The former is probably constitutional and appears as a tubercular affection of the skin, more especially of the face, attended with some loss of sen.sation ; it is usually ushered in with slight febrile disturbance and local oedema. As it advances the skin thickens and the tubercles multiply ; the disease spreads and involves the tongue, mouth, no.se, eyes, and even larynx and lungs. In extreme cases ulceration and disease of the bones exist, the subjects of the affection dying from exhaustion if not from suffocation. It is, happily, rare in this country, although it does occur occasionally ; it is, however, common in Nor- way, in the Mediterranean, and in the Indies. Dr. Webster in the Meil.-Chir. Trtnn^. for 1854, and Mr. Day in the Madron Quart. Journal for 1800, give valuable information upon the subject; and Dr. Carter in the Trans. Med. and Phijs. Society of Bombay, vol. viii.. new series, enters fully into its pathology. The disease has been regarded as incurable, although, since the introduction in 1873 of the Ourjun or wood oil by Dr. Dougall of the Indian medical service, better results of its treatment have been realized. The oil is used as an external application, made into an emulsion with lime water, in the proportion of one part to three, and should be well rubbed in twice a day for two hours at a time. It has ahso to be taken internally in two- drachm doses mixed with the same quantity of lime water twice a day. With this treat- ment the tubercles are said to soften down, and in their place watery blebs form, which burst and discharge a clear .serous fluid, and then the induration gradually subsides. The oil taken internally is a diuretic and purgative. Elephas. To the surgeon the second form of elephantiasis, or the Elephantiasis Arahnm, is of the greatest interest. It is quite distinct from the true leprosy. It appears generally in one or other of the lower extremities or in the male or female genital organs. It shows itself as a general infiltration into the skin and subcutaneous tissue of an organizable material, whereby the integument becomes hypertrophied and greatly thickened. It is commonly associated with some enlargement of the lymphatic glands, and frequently with dilatation of the Ivmphatics. It is occasionally associated with chyluria. In advanced 12 178 ELEPHAS. Fig. 65. disease the skin falls into great folds, and between these fissures form, which subse- quently pass into oozing ulcers. At times the foot and leg become the seat of extensive ulceration, which rarely cicatrizes. It generally begins with some febrile attack, and the aifected part becomes the seat of erythematous redness and swelling, which sub.side, again to recur ; each attack leaves some extra thickening behind it. I have ohserved this very clearly in many cases, and have no doubt that the erythema had some di.stinct relation to the disease. Treatment. — Dr. Wise of Calcutta in 1835 looked upon elephas as a disease of the venous system and inflammatory. 31r. Day. in the paper already alluded to. regards it as consecutive to malarious fever, while 31r. Dalton {Loncet, 18-lG) looks upon it as a constitutional disease, like the leprosy; and upon this theory the sciatic nerve of the afiected limb has been resected by Dr. J. S. Morton of Pennsylvania with some success. Dr. Carnochan of New York believes it to be associated with an enlargement of the arterial trunks of the part, and upon this theory based his practice of tying the main artery of the limb, thereby starving the disease. He performed this operation for the first time (in January-, 1851), and the success he met with, as published in a memoir on the subject in 1858, induced me to follow his example in 1865. My case in all its details was published in the Med.-Chir. Trans., 1866, and the benefit of the operation was most striking. It occurred in the case of a Welsh girl aet. 25 ; the disease had been of two years' standing and was spreading. The thigh of the affected limb (Fig. 65) measured twenty-seven inches round and the leg nearly twenty-three, the affected leg being nine inches in circumference larger than the sound one. and the thigh seven. Five weeks after the ligature of the external iliac artery the calf of the aff'eeted limb measured .seven inches less than it did at the time of operation ; and when she left the hospital^ the limb apjieared as in Fig. 66. The rapid disap- pearance of the thickened tissue was very remark- able. Since the operation the girl has gone on well, is companion to a lady, and can now walk ten or twelve miles. The limb becomes slightly (Ede- matous only on over-exertion. I have performed the same operation three times since, but not with similar success. I liga- tured the femoral artery of a man who had the whole limb involved, the thigh being only slightly so, and for a time everything promised to be as suc- cessful as in the case previously recorded ; but an attack of erythema came on. followed by renewed swelling of the extremity, which never disappeared. In this case the size of the superficial femoral artery was extraordinary, the loop of the .silk liga- ture when it came away being capable of admitting a No. 12 catheter. The vessel seemed to be nearly the diameter of my finger and was very thick. In a more recent case, however, gangrene of the foot, followed b}" death, took place. When this operation is performed, the vessel should be ligatured well above the dis- ease. I may add that Butcher in 1863 and Alcock in 1866 had succes.sful cases, though Sir Joseph Fayrer and Buchanan of Glasgow have not met with successful results. AVhen surgical interference of this kind is not applicable, elevation of the affected limb or pressure should be employed. In severe cases amputation may be called for. On three occasions I have had to circumcise patients with elephas of the penis and scrotum, and in each after the operation the whole of the thickening of the scrotum dis- appeared. This fact is worthy of record. Pathology. — Within recent times an opinion has gained ground that the true pathol- ogy of this elephantoid disease is to be found in the lymphatics and that it is due to lymphatic obstruction. It has. moreover, been thought by Dr. T. Lewis that the pres- ence of the Filaria .fant/iiiin's hominis might have something to do with it. since the para- site has been found in the blood of patients who have had elephas. In support of this view a very striking paper has recentlv been published by Dr. I'atrick ]NIanson in the China Customs Ca-effe. Medical Report, for the six months ending^ March. 1882. an abstract of which mav be read in Med. Times and Gazette, Feb. 12, 1883. Case of Elephantiasis Arabum before and after the Application of a Ligature to the Femoral Arterv. n\ I'M:. [SITES. 179 " In the instances, " writes Munson, • in wliicli tlic jcucnt worm lias hccn diM-fivcreil, she was f'(iun^. If this process of parturition occurs prematurely, or peristalsis is too vigorous and extends to a point high up in the uterine horns where the embryo has not yet comjiletely stretched its chorional envelope, then ova are expelled. These, as they reach the glands, where the afferent lymphatic breaks up into fine capillary vessels, act as emboli and jdug u|) the lymph-channels one after another until the fluid that carries them can no longer jiass. In this way the gland or gland.s directly connected with the lym- phatic in which the aborting female is lodged are thoroughly obstructed. Anastomoses for a time will aid the passage of lymph, but the anastomosing ves.sels will carry the embolic ova as well as the lymph. The corresponding glands will then in their turn be invaded, and so on until the entire lymphatic system connected directly or indirectly with the vessel in which the parent worm is lodged becomes obstructed." The degree of embolism and location f>f the worm determine the site and character of the resultant disease. ON PARASITES. Guinea- W^orm. — The Drdcmicnlus or Filaria inedinensis is one of the most trouble- some parasites known in Africa, Asia. India, and tropical America. In Europe it is only occasionally met with in those who have visited the above districts. The mature worm varies in length from two to six feet. It is cylindrical in form, white in color, has a smooth surface, is tough and elastic ; its mouth appears as a circular orifice and it has no anus. How it enters the body is unknown, although ^'^'- "'• it is evident that it does so from .> without, and probably through the ^i skin of some part that has been in ij^ contact with water, inasmuch as it '^ is more eomnmn in the feet than in other parts of the body, although the Madras water-carriei's are said to have them in the V»ack. At any rate, the worm gets into the subcu- taneous areolar tissue, where it re- mains. Busk tells us that it does so usually for aVjout twelve months, although it may l^e eighteen. When mature and tlie time has come for the discharge of the embryos with which it is filled, it makes its presence known by boring the skin, protruding its head under the cuticle, rais- ing a bleb, and coming out bodily, discharging its young filariae externally. Treat.ment. — The first manifestation of the disease is usually a circular bleb, as rep- resented in Fig. (57. although it often happens that pain and stiffness of the affected part have been complained of for some time previously. The bleb contains sero-purulent fluid, and the surgeon, in order to find the worm, should cut the raised cuticle off. " There will then be seen protruding from a little hole in the centre of the denuded cutis one or more inches of the worm, of the size and color of vermicelli or of a wax match. The surgeon now makes a small quill-like roll of adhesive pla.ster, rolls the worm around it, and gently draws as much as will come without the risk of breaking; and this is repeated day after day. till at last the tail, which end- in a small hook, comes wriggling Guinea-Worm Bleb just ( ut oH". (Dr. Druitt, Med. Times and Gaz., Jauuary 3, 1874.) 180 ON PARASITES. out, and the case is at an end." ' Under these circumstances a rapid cure takes place. Should the worm break, a subcutaneous abscess is almost sure to form higher up ; and when this is opened, a loop of the worm can most likely be got out on a probe, and so be extracted as before. At times no bleb forms, but merely a subcutaneous abscess. In exceptional ca.ses more than one worm may exist. Druitt quotes a case in which nineteen had been extracted. Cnn,-(■ wouikUhI by accitlcnt jpira- tion and threatened life. Treatment. — When indications of absorbent inflammation appear, the wound or sore should be well cleansed, the scab removed, and any collection of pus let out. The affiected limb should be raised, the foot, when involved, brought higher than the hip. the hand or elbow than the shoulder, and warm poppy fomentations should be applied along the whole course of the lymphatics up to the group of glands in which they terminate. Some sur- geons, particularly the French, advise that the inflamed line should be pencilled with caustic and dry warmth applied, such as cotton-wool ; but I prefer the practice already indicated, as 4t gives more comfort. The application of the extract of belladonna and glycerine to the part is also most beneficial. ISFLAMMATIDS <>l' LYM I'lIATU'S AM) THEIR (iLANDS. 1«3 As soon as su|>|)iiratii)ii a])|)oars tlio abscess must be opened, whether tliis follows directly upon the iiitlaniniation or subse(|U(!ntly. At the vc^ry earliest period of the intlanunation, when the tonj.nie is foul, an emetic has some influ<'nc«i in checking its prog- ress. A good saline ))urge is also beneticial. Sedatives slionld bo given to allay pain, su(di as small doses of morphia three times a (lav, with a donl)le dose at night to induce sleep. When siip)Hiration has taken place, tonics may be administered, of which iron is the best. In chronic cases, where induration in the track of the ducts remains, mercurial (unt- ments and IViction are sotnetimes valuable. Glands, and particularly those in the neck, are very apt to inflame after fevers or the exanthemata, and to give rise to much local distress. In j)atients who are not extremely feeble these eidargements. as a rule, subside by themselves under careful management, though in exceptional cases they suppurate. Local warmth a])plied by means of cotton-wool, tonics, and nutritious food are the best remedies ; but when supjiuration threatens, warm fomentations are more grateful to the patient. Ab.sce.s.ses should be opened early. Before opening, however, it is well to try what drawing ofi" the pus by means of the "aspirator" may acc'omplish, repeating the operation as the pus re-collects. In some instances a cure may Vje effected by these means, and thus a scar is prevented. Should aspiration fail, an incision ought to l>e made. The local application of iodine under these circumstances, although ii common remedy, does n(tt ajipear to be of much value. Chronic glandular enlargement is a very common affection. It is found in the strumous and feeble child as a chronic and slightly painful enlargement of a gland or glands, more particularly those beneath the jaw and about the neck, and comes on either after exposure to cold, some slight illness or local irritation, such as bad teeth, or without any definite cause. It often subsides spontaneously on the removal of the cause or on the improvement of the general health. At times these glands suppurate and leave ugly sores, the cellular tissue around the gland becoming destroyed and the skin conse- quently undermined. The pus from these glandular enlargements is sometimes ill formed and curdy ; and when it attends the breaking down of some old disease, it may contain a chalkv deiHisit, the produce of some degenerated or dricd-up tuberculous or other matter. Hodgkin's Disease of the Glands, or General Lymphadenoma.— There is, however, another chronic enlargement of the glands that appears to diflFer in all ways from the local enlargements to which attention has just been drawn. It was first described by Dr. Hodgkin in the Med.-Chlr. Trans., vol. xvii., and may be called Hodgkin's disease of the glands, or, for the sake of distinction, glandular tumors. He observed it first in the mesenteric glands, though any or all may be affected. In it the glands become very much enlarged, even to the size of an egg, and apparently more numerous; they present a smooth external appearance and have a soft semi-fluctuating elastic feel. On section the surface of the gland presents a .smooth, bloodless, semi-trans- parent, loose, succulent structure ; microscopically, it is made up of glandular tissue and abundance of fibro-nucleated tissue ; it is of a tough, leathery consistence and exudes a clear serous fluid. The tumors are always free, each being separable from the others. To the surgeon the disease at times appears as a local movable glandular tumor of a slow painless growth which medicine has little or no power of influencing ; it has the local clinical appearance of a benign fibro-cellular tumor, and has often been excised as such. In other instances the tumors are multiple, three, four, or many more existing in one locality, chiefly in the neck. In exceptional instances the tumors are more numerous. I have seen cases in which, on one side of the neck, the subcutaneous tissue seemed filled with loose glandular tumors readily movable one upon the other, as if simply confined by skin, in the same way as the adenoid tumors of the brea.st are occasionally met with. In still rarer examples the whole glandular .system seems to be affected, every group of glands not only being apparently enlarged in size, but also increased in number. This disease is often associated with an enlarged spleen, and appears pathologically to be allied to that blood disea.se now known as leucocythfemia, notwithstanding that in many in.stances the white corpuscles are not in excess. On one occasion I had an opportunity of watching the gradual development of this aflfection. It began in the cervical glands and gradually involved the whole glandular system, the patient, a boy at the age of fifteen, dying with an enormous spleen and gland- ular tumors in every region. His blood was made up almost entirely of white blood cor- puscles, death resulting from exhaustion. 184 DISEASES OF THE THYROID GLAND. Another ease I treated five years ago, a woman aet. 56, has lately returned conva- lescent from lymphadenoma, but affected with an acute cancer of her breast. Treatment. — For the ordinary or strumous enlargement of the glands in children there is no drug equal to cod-liver oil, the syrup of the phosphate or of the iodide of iron or the tincture of quinine being capital additional remedies. I have not much faith in the local application of iodine in the form of the tincture, as after the second application the skin ceases to be an absorbing surface, and the iodine becomes, therefore, a mere irritant. For some years I have been accustomed to order the solid iodine to be placed in a perforated wooden box and on a shelf in the sitting- and bed-rooms, the iodine in this way evaporating gradually and iodizing the air. In all glandular, as in thyroid, enlargements, this mode of employing the drug seems to be of considerable value. The iodide of ammonium as an ointment is a useful application when rubbed in, the iodide by this process becoming absorbed. Good food and fresh air are also essential points in the treatment of these cases. In Hodgkin's glandular tumors full doses of iron, as well as of cod-liver oil, seem to be the best remedies — that is, patients who can take them appear to improve in their general health, while the disease does not progress so rapidly under their use as without it; but upon the ultimate issue no remedy seems to have any decided influence. The late Mr. Bradley advocated strongly the administration of pihosphorus in doses of one-fiftieth to one-fifteenth of a grain twice a day. Indeed, I am disposed to think that where the enlarged glands can be removed they should be, for I am sure that I have seen life pro- longed by such an operation, if not a cure of the disease brought about. When, however, the spleen or liver is involved, no operation is justifiable. When isolated glandular tumors exist, they may be dealt with as local tumors and removed. In all glandular enlargements, however, the local cause of irritation should be looked for, with a view to its removal ; for practically it is well to regard all glandular enlarge- ments as due to a chronic source of irritation, in the same way as acute adenitis is known to be a result of inflammation of the lymphatics. Disease of the glands, as connected with cancer and syphilis, is referred to in the chapters devoted to these subjects. DISEASES OF THE THYROID GLAND. The thyroid is a lobulated, encapsuled, ductless gland with a cellular structure, the cells of which contain a glairy fluid. It is highly vascular, and has as large a vascular supply as any gland in the body ; it is supposed to have some connection with blood formation. It is also freely supplied with lymphatics. The entire gland may be congeni- tally absent. When it is simply enlarged, it is said to be hypertrophied, or the seat of goitre or hronchoceJe — simjyle adenoid enlargement — and it is well known that these goitres attain a large size. Sometimes they are apparently composed of simple increase of tissue, the enlarged gland having much the same appearance on section as the small and healthy one ; at other times the structure of the tumor is coarser, more cellular, or cystic — n/atic hronchoceJe— i\ie cysts occasionally assuming large dimensions ; while in a third the gland is more solid and fibrous or more or less mixed with cysts — -fihron>^ Irronchocele. The thy- roid gland may inflame as well as suppurate, and may be the seat of distinct adenoid tumors or of cancer. Hydatid cysts have also been enucleated from its body (^vide Prep., Guy's Hosp. Mus., 171 1"'")- Goitre — or Derbyshire neck, as it is generally known in England — is very common. In its most usual form it appears as a simple bronchocele or hypertrophy of the thyroid gland, and gives rise to symptoms which are mainly attributable to the size of the tumor. At times, however, small tumors cause symptoms such as dyspnoea or the cough as of a broken-winded horse on exertion, and even difiiculty in breathing on the slightest cause. At other times they mechanically press upon the large vessels and respiratory tract, pro- ducing headache and a feeling on stooping or coughing of fulness in the head, with evident respiratory obstruction, and even difficulty in deglutition. These symptoms may also appear for a time and then disappear, leaving the patient comfortable in all respects during the intervals. In other cases goitres which appear to be of the simple kind begin to pulsate under excitement or other unknown cause, and are attended with some pro- trusion of the eyeballs. These symptoms disappear with rest and time, and the case subsequently reassumes the clinical features of a simple goitre. All tliese tmnors rise and fall icith the larynx in deglutition. disI':asI':s of riih: tiiyi:<)Ii> i.la.M). 185 Fig. 68. Such cases as these stan«l as a kind of link lictwccn tin- sini|ilf and tliat known as the e.roj>h//iii/mir ^'oitre, (iraves s or IJasedow s dist-asi-; and yet Ix-twi-cn these lw(» affections there innst be some wide differenee. lor the siniide jroitre appears to he a hical affV-etiun, whereas the exophthahnie lorni is prohaltly part of" u more <:eneral disease marked hy the enlargement of the thyroid hody, often hy prominenee of the eyohalls. always hy palpita- tion ved. and the whole suhject requires investigation. TuK.VTMKNr. — Siin])le goitres are to he treated on ordinary jirinciples — viz., hy atten- tion to the genera' health, the inhalation of fresh air. and hy tonic medicines. Filtered or distilled water such as the salutaris should always he taken, more particularly in dis- tricts where chalk, lime, and magnesia ahound. In Derhysliire and the Tyrol districts it is generally believed that it is from the water that the disease is produced. Iodine has always been held in high repute in this aff"ection, originally as burnt .sponge and recently in the form of the iodide of potas.sium ; and in four- or five-grain doses, given with bark or (juinine, this drug is of use. For .';ome years, how- ever. I have given tonics alone by the mouth, and have ordered the air of the room to be kept iodized by means of solid iodine put into a box with a per- forated lid. as already described ; the metal thus evaporates steadily into the room where the patient sits and sleeps, and in this way it becomes absorbed. Under its influence I have often been surprised to find how rajtidly goitres disappear. With this treatment I at times rub in an ointment of the iodide of ammonium, a drachm to an ounce. To paint a goitre with the tincture of iodine is useless, as one application renders the skin hard and incapable of absorption. Dr. R. Stoerk of Vienna (1874) injects alcohol into the soft parenchymatous and cystic varieties, one or two drachms being introduced by means of a Pravaz .syr- inge, turning the goitre hard by causing coagulation of its colloid contents. The injec- tions should be repeated at intervals of several days in diff"erent parts of the tumor. He, however, advises that a few drops of iodine should be added to the alcohol, to prevent fermentation taking place. Dr. Llicke of Berne is in the habit of treating hard goitres by injecting strong tincture of iodine into the tumor, one or more punctures being made at a time according to the size of the tumor, and, he reports, with good success (Lancet, 1859). Dr. Mouat of Bengal spoke (Indian Annafs of Med. Science, 1857) very highly in favor of the use of biniodide of mercury in combination with the rays of the sun for the cure of goitre. He used the mercury as an ointment of the strength of three drachms to a pound of lard. It was rubbed in for t*en minutes an hour after sunrise, and the patient had afterward to sit with his goitre held well up to the sun as long as he could endure it. After this a fresh layer of ointment was to be applied with a careful and tender hand, the patient sent home, and the ointment left to be absorbed. In ordi- nary cases this treatment was said to have been sufficient to eff'ect a cure, and that only in exceptional cases was a fresh application necessary. He gives his cases of recover}' by thousands. It is possible that in England the treatment has failed for want of the rays of the sun. I have tried it without the .slightest beneficial result. The practice I have followed with encouraging success during the last few years has been the injection into the tumor of 20 or 30 drops of a mixture in equal parts of the tincture of iodine and alcohol. In some cases one injection brings about a cure ; in others many are required. In Graves's di.sease iodine appears to be not only useless, but injurious. Tonics, more particularly iron, are apparently the most applicable. In exceptional cases a goitre may so increase and press upon the larynx and sur- rounding parts as to threaten life, and may even cause death by a gradual process of suff"ocation, but more commonly by exciting some sudden laryngeal spasm. In 1869 I treated such a case, sent to me by Mr. Holman of East Hoathly. in which a large thyroid Exophthalmic Goitre (Wilks's case). 186 DISEASES OF THE THYROID GLAND. gland was causing chronic suffocation by its mechanical pressure, and it ultimately pro- duced immediate death by exciting some laryngeal spasm. Dr. Herbert Da vies has recorded a similar ease {FoJh. Soc. Trans. , 1849). and in the museums of St. Georges and Bartholomews hospitals preparations exist with similar histories. In .some cases the treatment by setons has been of value, suppuration of the thvroid having been followed by a rapid subsidence of the hypertrophied or fibrous structure of the gland. Mr. Hey of Leeds adopted this practice with much success. In other exam- ples of goitre the question of operative interference may have to be entertained, and will be considered in another page. Cystic Bronchocele. — Cysts are often met with in this gland, and occasionally they assume large dimensinns. They appear as more or le.ss globular, tense, fluctuating tumors moving up and down with the larynx, as all thyroid tumors do. Thev mav con- tain only the glairy fluid of the gland, or a more serous or sanguineous fluid or old gru- mous blood. Occasionally, on being punctured, they will go on bleeding, even to the death of the patient. Such cysts appear either in one or other lobe or in the isthmus. In 1872 I treated, with Dr. Hess, a case of blood cyst of the isthmus- in a girl, and drew off about half an ounce of a thick, grumous. coff"ee-looking fluid. In 1803 I tapjied a cyst the size of a cocoanut in the right lobe of the thyroid of a woman aet. 2(J which bled pjrofusely. and the hemorrhage was onl}- arrested by closing the wound. The cyst filled up at once nearly to its former size, but subsequently gradually contracted ; and after five or six years scarcely any remains of it could be found. Simply tapping a serous cyst may cure it. "When it fails, the cyst should be injected with half a drachm of the mixture of iodine and alcohol, mentioned above, or. on this failing, of one of the .same mixture and the liq. ferri perchloridi in equal parts. When these fail, a .seton ha.«» been recommended : but the practice is dangerous and .should only be adopted when sim- pler means are unavailing and further intei-ference is requisite. In cysts of the isthmus, more particularly blood cysts, an incision into the cavity is a good and successful opera- tion. Should a cyst, after tapping, suppurate, it must be dealt with as an ab.scess and freely opened as soon as the existence of pus can be made out ; for the thyroid is in a dangerous -position for suppuration to occur. I have .successfully treated one case of suppurating thyroid cyst after tapping by incision, but the cases in which this treatment is called for are rare. Dr. M. Mackenzie has (Lancet. May. 1872) advocated the practice of converting the cy.stic disease of the thyroid into a chronic abscess by the following means : •• First empty the cyst. When p»racticable. it is well to make the puncture as near as possible to the median line and to select the most dependent portion of the tumor for the intro- duction of the instrument. As soon as the trocar is felt to pierce the cyst-wall it should be withdrawn, and the canula passed farther in by means of a blunt-pointed key. The fluid having been withdrawn through the canula. a solution of the perchloride of iron (two drachms of the salt to an ounce of water) is injected through the canula by means of a syringe. The plug is reinserted and the canula secured in position by a strip of plaster. The injection of iron is repeated at intervals of two or three days until suppura- tion is e.stabli.shed. A\'hen this, point is reached, the tube is withdrawn, poultices are applied, and the case treated as a chronic abscess. Where the tumor consists of more than one cyst, it may be necessary to make a second or a third puncture ; but it fre- quently happens that other cysts carf be opened through the cyst originally punctured." Some cysts become calcareous and should be treated by excision. The practice is only, however, to be entertained when the cyst cau.ses symptoms which threaten life. In Guys Hosp. Museum there is a preparation of a calcareous cyst with an intra-cystic growth. Acute inflammation of the thyroid gland is doubtless a rare affection. I have never seen such a case. Holmes Coote records one in Holmes's System. Suppura- tion of a cyst in the daiid after surgical interference is more common. Acute hypertrophy may appear and produce dangerous, if not fatal, symptoms. Sir Risdon Bennett, in his interesting Lnmleian Lectuns for 1871. has recorded such an instance, which I had the advantage of seeing in consultation with him and Mr. Jack.son of Highbury. It was in a young man aet. Ifi. who three months before became the .sub- ject of paroxysmal attacks of asthmatic dyspnoea, associated at times with a wheezing or whistling respiration and some general enlargement of the base of the neck. Three days before his death this difficulty became extreme, the paroxysms became more frequent and severe, and on the day of his death a severe paroxysm took place, which passed on to a forced and heaving respiration bevond anvthinsr T had ever before witnessed, and speedy DfSIJASKS OF Till-: TUYHoin f.'f.AXl). 87 death resulted. I performed tracheotomy upon the ]):itit'iit with the slender liope that some lijrht inijjht he thrown H])(m the nature (jf tlic; (rase to ^'uidc us in its treatment, if not to erforated instrument with me lonnir the sides of the trachea. The trachea Ixdow my o|»eninf; was flattened laterally to within half an inch (d" the hifur- eation and was also twisted to the left, hein;^ surrounded hy the t:reatlv enlarged and firm lateral lohe of the thyroid. The structure of this eidarged gland was clearly that of hypertrophy, not of cystic or other aj)j)arent disease. As an examj)le of acute rapid hypertrophy of the thyroid, the case, says liennett, "points to the propriety of regarding any acute enlargement of this gland in young ))e()ple with more anxiety than we are per- haps accustomed to do." particularly, it should he added, when the lohes of the gland pass down heliiml the sternum. Thyroidal tumors ilouhtless exist, although they are ncjt common ; these may he adciifiiil and iiuioeent or cunceroiix growths. An adenoid growth may appear as a tumor within the gland itself or connected with it, or more commonly as an intra-cystic growth similar to that seen so frequently in the hreast. In their clinical history such cases cannot well he diagnosed iui. C>9. Fig. 70. from the ordinary goitre, although, when the disease is unilateral and assumes a rounded or irregular form and appears to be an isolated out- growth of the gland itself, the nature of the tumor may he suspected ; when placed, however, within the gland it- self or within a cyst in the gland, the diagnosis is impossible. In Fig. 69. taken from a drawing by Dr. Moxon of an old preparation in the Guy's Hospital Museum (1711^'), a tumor the size of a grape is depicted hanging down loosely by a pedicle attached to a lobe of the gland. In the gland there is a well-marked, cuplike depression, from which the tumor had fallen out, the pedicle mainly consisting of a large artery emerging from the gland. The growth had an ossified capsule and was composed of a structure like that of thyroid tissue (Fig. 70). My late colleague, 3Ir. Poland, has recorded a like case in which excision was. successfully performed (Gui/'s Hasp. Rep.^ 1871). Frerichs, Rokitansky, and Virchow record somewhat similar instances. Paget thus refers to the subject of accessory thyroid tumors : " These growths of new gland tissue may appear not only in the substance of the enlarging thyroid, but external to and detached from the gland. Such outlying masses of thyroid gland are not rare near bronchoceles, lying by them like the little spleens one sees near the larger mass. Their history is merged in that of bronchoceles (see Virchoic, lect. 22), with which they are usually associated, whether imbedded as di.stinct masses in the enlarged gland or lying close to it. but discontinuous." Cancerous growths appear as infiltrating affections of the gland or as distinct tumors : they have no special clinical characters until they attack the surrounding tissues by continuity or break down. In a case of my own the disease perforated the trachea. The Guy's Hosp. Mus. contains four preparations of this disease. Pedunculated Tlivroidal Tumor. Microscopical .\p])earance of Thyroid Glands. (From Dr. .Moxon's drawing.) Operative Interference in Thyroidal Tumors. Many operative proceedings have been suggested and adopted for goitre and thyroidal tumors. Sir AV. Blizard. Earle, and Coates (Med.-Chir. Trans., vol. x.) tied the superior thyroid arteries, with the view of .starving the disease, and Coates's attempt was attended with success ; but the operation is necessarily a severe one, and the free arterial supply from the inferior thyroid arteries tends to neutralize its good. At the present day it is properly discarded. Setons have likewise been used with good success aneconiing involved. However trivial an injury of the head may appear to be. it is never to be lightly regarded, since what may seem a simple cutaneous bruise the result of a blow upon the head unaccompanied by any symptoms of brain disturbance may be followed by an acute inflammation of the diploe of the skull — a condition fraught with great danger — or a chronic inflammation of the bone, which is scarcely less serious ; and when, as a primary effect of injury, there is evidence of brain concussion, which, as a rule, means brain bruising, the risks of secondary hemorrhage or intracranial inflammation are not slight. The latter complication follows the slighter as well as the graver injuries. It is well for the student to have these truths impressed on his mind at the beginning of a chapter on injuries of the skull, for they have a practical bearing of wide importance. Contusions of the Scalp and Blood Tumors. The integuments of the scalp have this peculiarity — that they are intimately con- nected with the aponeurosis of the occi])ito-frontalis muscle ; indeed, practically, the.se parts may be regarded as one, for they are not to be separated and move together over the cranium. They are well supplied with vessels, and, conse(|uently, have consid- erable power of repair ; they rarely slough. When any great effusion of blood compli- cates a contusion, a blood tumor is said to exist ; and when this occurs on the scalp, the affection is known by the term cephal-hsematoma. In newly-born children this affection is frequently met with, and it is commonly, although not always, a result of a diflScult or instrumental labor. It is usually situated over the parietal bone, showing itself as a more or less circumscribed, soft, fluctuating tumor; but the largest I have ever seen was over the occipital bone. When the tumor is small and confined to one bone, the blood is probably effused beneath the pericranium (.sj/6/;^'/v'cr<7?( /a/ yb/-?>i). When the swelling is larger and spread over more than one bone, the effusion, doubtless, is poured out beneath the apoueurosis of the .scalp (^linlxiponeurotic form'). In the subpericranial form the indurated base may organize, or inflammatory matter may be poured out around it and assume the character of bone : whil.st in neglected cases suppuration may follow, which occasionally passes on to involve the bone itself. In the subaponeurotic form the blood is generally rapidly absorbed, and during the process a peculiar characteristic crackling sensation will be often given to the hand in manipulation. In feeble infants this process of absorption may be delayed or may fail altogether ; under which circumstances, surgical aid is called for. In the adult, in addition to the forms of blood tumor just described as a consequence of injury, blood may be effused into the skin it.self. and appear as a hard unyielding lump. When a blood tumor has an imlurated base, rising from, and apparently continuous 1S9 190 SCALP WOVXDS. with, the bone, with a defined edge toward the centre, the idea may present itself that a fracture with depression exists. Under such circumstances the surgeon will be assisted in his diagnosis by firmly pressing his thumb or finger for a few seconds upon the ridge : this act in a recent case, by displacing the fibrin, reveals the uninterrupted continuity of the bony surface, and thus proves the nature of the case — more particularly when there is an absence of symptoms of fracture. "When the case is complicated with brain symp- toms or a ruptured artery, giving rise to pulsation in the tumor, some difficulty in diag- nosis may be experienced. Treatment. — A simpk contusion of the scalp, uncomplicated with any great eff"usion of blood or other local injury, requires little surgical attention ; it has a tendency to recover like contusions of other parts. Its best application is a cold or spirit lotion, muriate of ammonia in solution being as good as any. "When a blood tumor exists which feels tense or pulsates, broken ice in a bag or one of Leiter's coils (Fig. 9, p. -id) should be applied, the cold checking the further flow of blood and encouraging absorption. When the rupture of a large artery, such as the temporal or occipital, is suspected, as indicated by the pulsation of the tumor or other significant symptom, it may be advisable to apply pressure over the trunk of the vessel. When absorption of the effused blood does not take place, the cystic swelling should be aspirated and pressure applied, sponge pressure being the best ; and this operation may be repeated several times. Should tapping fail, an incision ought to be made sufficient to allow of the free escape of the pent-up fluid and to prevent its re-collection ; gentle pressure should subsequently be applied on the part. In very obstinate cases the tumor may be treated as a serous cyst and injected with iodine. When the effused blood breaks up and causes suppura- tion — a somewhat rare result — a free incision with drainage is required and the case must be treated as one of abscess. During this period tonic treatment is often requir<;d to improve the patient's powers. When the tumor is large, the patient should be kept quite free from excitement and the diet carefully regulated according to the special wants of the case. As a rule, all such cases do well. Scalp Wounds. Wounds of the scalp are very common, and large portions of the scalp may be torn away from its connections with the pericranium or bone and on readjustment live, though much bruised and injured, the extreme vascularity of the scalp favoring its repair. Such injuries, when not complicated with injury to the skull or its contents, generally do well. Blunt instruments, forcibly applied, produce scalp wounds very like those caused by sharp- cutting ones.' Wounds which exhibit entire hair bulbs projecting from the surface of their sections have been probably produced by a blunt instrument, while on the other hand, when the hair bulbs are found cut, the wound has to a certainty been caused by a sharp one. It is generally thought that scalp wounds are especially " liable to prove the exciting cause of erysipelas." I doubt the accuracy of such an assertion, because from my notes of 175 cases of .scalp wounds admitted consecutively into Guy's in eight years — and it must be added that only the severe are admitted — I find that erysipelas followed only in three, or in 1.71 per cent., this proportion being about the same as that obtaining in sur- gical cases generally. Lacerated or contu?;ed wounds of the scalp rarely slough and should be treated as the incised. Punctured wounds are. however, liable to be followed by diffused inflammation beneath the scalp. Treatment. — Under all circumstances and conditions, scalp wounds should be gently and carefully cleaned with tepid water and their edges adjusted and maintained'in posi- tion ; and to aid this the hair should be removed in the neighborhood of the wound. When the wound is not exten.sive and its edges can be adjusted by plaster, sutures are not needed; but when any difficulty is experienced, they may be as fearles.sly applied to the scalp as to other parts. In extensive lacerations, indeed, the application of sutures is decidedly preferable to any other form of practice, ina.smuch as with their use the wound can be kept clean and moist by dressings, which is not possible where a quantity of strapping has been employed. In the application of the suture, however, care must be taken not to include the aponeurosis of the occipito-frontalis muscle, for there is more danger of setting uyj mischief in the cellular tissue beneath this tendon when this prac- tice is adopted than when the sutures simply pass through the .skin itself. The kind of ^Vide paper Glasgow Med. Jonru., January, 1876, bv Dr. Wm. MacEwen. CONTUSION OF Tin: HOSES OF THE SKULL. 191 HUturo is iiiiiiii|Mirt;iiit. altliuutrli iimiiy sur<.M'(iiis prcl'tT the iiii'tallic. All sutures sliouid be rciiidVi'd (111 till' sccdiid day, as wnuiuls of the sral|i Ileal raiiidly. Tlic head in all tlu'Sf i-asi'S sliduld Ik' kept cunl. W'lu'ii tlu' iiericraiiiuiii is t(trii ott' and tin- Ikuk- cxjioscd, no diflcrcnff in ])racticc i« iK'fdfd. I lie jinisiR'cts oi" a satisfactory rc'covi-ry under these eircuiiistaiiees heiiij: as <;ood as ill a less eoiiiidieated ease. When the Immic. however, has heeii iniieli iiijure(l, super- tic'ial neerosis may lollow. Should e.xudative or inHaiiiiiiatory fluid eolleet heiieath the flaps, the sooner a free escape is jiiveii to it the better, since by its retention suppuration, wliieli is always as.soeiated with great danger to the perio.steiini, to the bone, and even to the life (d" the patient, is encouraged. To attain this end the edges rd" the wound should be .separated in parts l>y iiieans of a jirobe. (»r iiniifn/ incisions should be made through the tissues down to the 1 e. By adopting this practice early the inflammation will often be prevented or cheeked and the extent of mischief limited. When diffused supjuiratioii has taken place beneath the scalji. the juis sliouhl be evac- uated by incisions well placed for drainage, the acticjii lA' the occipito-frontalis muscle con- trolled by tlu" jtressure of a circular elastic liandage or strapjiing. and the surfaces of the suppurating cavity ke)>t in apposition by spfuige pressure. To the wounds absorbent aiitisejitic dressings should be applied. When extensive sloughing takes place, there is no reason why a good recovery should not follow if the powers of a patient be good and his kidneys sound. The powers of a patient must be kept up by tonic medicines, such as iron or quinine, generous diet allowed, and stimulants employed when needed. Sedatives to procure sleep are also essential. When bleeding is troublesome, the arteries should be twisted, acupressed. or ligatured ; when it occurs merely as a general oozing of blood, pressure may be applied either to the wound or to the trunks of the supplying vessels. In rare cases, where the deep vessels of the temporal fossa are wounded and bleeding cannot be arrested, the question of apply- ing a ligature to the external or common carotid may have to be entertained. It has never fallen to my lot, however, to witnes's such a case. Contusion of the Bones of the Skull. This is. doubtless, a common consetjuence of scalp injuries both with and without a wound, as is a scratching or abrasion of the bones; and yet in the majority of such cases a good recovery takes place. In exceptional cases, however, a ditterent result is met with, in the shape of either an acute inflammation of the bone with all its dangers, or a chronic inflammation with all its difficulties. Acute nifiamiiuition of the bone is a severe affection, more particularly when the diploe is involved; for the diseased action may extend inward and give rise to a local suppura- tion between the bone and the dura mater or between the layers of the arachnoid, running on to a diffused inflammation of this membrane and of the brain itself. A chronic injiammntion of the Itorte may be followed by very similar results or by a thickening of the injured bone. W^hen neerosis of the skull is present, these results are always liable to occur, and with it a low kind of jthlebitis of the cerebral sinuses and pyjemia are prone to follow. Symptci.ms. — The symptoms which indicate either of these two conditions appear at variable periods after the accident and vary in intensity according to the action. In OAiite cases the symptoms may show themselves within a few days with severe constitu- tional irritation and headache, passing on to general brain disturbance, convulsions, paralysis, coma, and death. In chronic disease the symptoms may not appear for weeks or months, and they will be less severe ; but persistent headache is always present. When the inflammation spreads inward toward the arachnoid and brain, other symp- toms show themselves, such as severe local pains, delirium, twitching of the muscles, convulsions, paralysis, coma, and death, the rapidity of the progress of the disease gov- erning the symptoms. When marked rigors appear, suppuration is indicated, often of the py.-emic'kind ; and convulsions of an epileptic nature are frequently found in the chronic form of the disea.se. Fersi.slent hemhiche after an injury to the head is always a symptom demanding anxious attention, as it too often means progressive mischief within the skull. This subject will, however, receive further elucidation in the chapter on " Intracranial Inflammation." 192 FRACTURES OF THE SKULL. INJURIES OF THE CRANIUM. There are some leading practical facts or principles which should be impressed upon the memory of every surgeon who has to deal with injuries to the head. These I have formulated as follows, believing it to be well to place them at the beginning of a chapter on such injuries. 1. A concussed should be regarded clinically as a bruised brain. 2. Fractures or injuries of the skull are of importance so far as they are associated with damage to the skull contents, a compound fracture uncomplicated with .shaking of or injury to the cranial contents being less liable to be followed by bad results than a simple fracture associated with brain mischief. 3. The amount of injury to the brain cannot be estimated by the severity of the pri- mary symptoms, a severe injury to the brain being frequently associated at first with mild, and a slight injury with severe, symptoms. 4. A general shaking (concussion) of the brain, whether associated or not with simple or compound fracture, may give rise either to temporary suspension of brain functions, ending in recovery, to laceration of the membranes, to a more or less severe bruising of the cortical structure of the brain, or to laceration of its deeper substance. The amount of hemorrhage which complicates the case depends upon the size, number, and healthi- ness of the ruptured vessels. Thus a general shaking or concussion in a healthy brain may only produce a temporary suspension of cerebral functions, when the same injury in an unhealthy or aged one in which diseased vessels ramify may be followed by a fatal hemorrhage or apoplexy. 5. Under certain conditions of the system, and particularly where the kidneys are diseased, a slight concussion will be followed by a fatal secondary inflammation of the. brain-coverings; while under other conditions a severe injury to the brain will be fol- lowed by no such result. 6. Intracranial inflammation is as prone to follow the milder as the graver cerebral injuries. 7. The character of the accident and the mode of its production furnish the best means for estimating the nature and severity of the injury and its probable results, since a fall upon the head from a height or a blow from a heavy weight causes a generul injury of the brain, and a fall upon or a blow from a sharp instrument a local one. With these general propositions, which the student should learn and think over as a guide, I now proceed to consider the subject of fractures of the skull. FRACTURES OF THE SKULL. These may be divided into fractures of the '• vmdt " and fractures of the " hnse^'' a third and large division including those of the '• vault and base." They may likewise be " sim- ple'^ or ^' compouiid." ''^ comminuted^" "■ depres-^ed" or "undepressed." Fractures of the vault are generally caused by direct blows upon the part or falls upon sharp bodies. They include most of the punctured fractures and incised wounds of the bone, as in sword wounds, etc. They are of necessity compound, and often comminuted ; and the brain injury which is associated with them is for the most part local. When not punctured, the fracture may appear as a simple fissure, the extent of which is determined by the amount and character of the force employed, the line of fracture being influenced by the sutures and ridges of bone. When the force is local and moderate, the fracture may be limited ; when concentrated and severe, the fracture will be "starred," and generally "comminuted." the fissures radiating in all directions, involv- ing many bones, and passing downward toward the base. When inflicted with a blunt- edged instrument, the fracture will be depressed in a gutter shape (Fig. 71) ; when with a round one, as a hammer, the bone will be depressed more like a '• saucer " (Fig. 72). Gutter- and Saucer-Shaped Fractures of the Sku FiiAcniiKs or Tin: shTi.L. 193 Coniiiiiiiuted Fracture of Skull with JJepre^^sion of luner Talile from Direct Local Vio- lence (Prep. Guy's Mus.;. Cunnniuiiftif /rncfitrrs ure trcni-rally the ri'.siilt of a coiict'titratiMl local violence, and are coiiseijucntly fomid chu-tly in tin- vault and are mostly conijioiind (Vijs. 7-i). In sonjo cases of fracture of the vault the hone will he (h'presscd ttr driven in upon the cranial contents ; in sabre wounds it may he elevated, ploughed up, or displaced outward. The fracture will he confined in some cases to the outer tahle of the skull, in rarer instances to the inner, a fracture with depression /. Srfeuc<\ April, 1882. b}' Mr. J. Lidell. As points of practice, however, it is well to remember that in all ordinary ca.ses of fracture, with depression of the bones of the skull, the injury to the inner table is far greater than to the outer, and the point of exit of any foreign body through the skull is always larger than that of entrance. Whether depression of the bones of the skull of an adult ever occurs without a frac- ture is an open question. There is certainly no good evidence in support of the fact. In children it has happened without giving rise to any symptoms of brain compression ; yet even here, says P. Hewett. •• .some of tlie bony fibres must have given way." In these cases tlie dcprc-st'il bone may subsequently rise up again to its natural level. Brain Complications. — The practical interest, however, attached to all these varieties of fracture is concentrated in the question as to how far the cranial contents are involved in the injury. Has the brain been slightly concussed, or so .shaken as to have been bruised or lacerated? Have the membranes of the brain been torn, lacerated, or injured? Is the fractured bone a .source of irritation to the dura mater? Is there a loose fragment of the inner taVde of bone acting as an irritant ? A compound fracture with or without depression, not complicated with brain di.sturbance or brain injury, is a cause of far less anxiety than a simple fracture in which severe brain concussion has taken place and is indicated by symptoms ; a severe shaking of the brain, whether com- plicated or not with a fracture, is a far more serious accident than any local injury to the skull alone. Fractures of the base of the skull or vault and base combined — for the.se conditions ought to be considered together — are invariably severe injuries. They are generally, except when produced by a crushing of the head, caused by a dif- fused force, such as that occasioned by a fall from a height upon the vertex or by a heavy blow. '-When the former, the plunge of the body is suddenly arrested by the vertex coming in contact with the ground, and the entire superincumbent weight, with the superadded momejitum ac(|uired by the velocity of the fall, is concentrated around the condyles of the occipital bone, and the central compartment of the base of the sknill is thus broken across" (Fig. 74). The fracture is the result of direct violence, and not of so-called contre-coup. " Thus, if the injury be inflicted by the fiill of a hm-d and heavy body on the vertex, this part would be fractured ; and if the weight were not very great, the mischief might end there, as the resistance offered by the head ma)" so far exhaust the momentum of the falling body that the force would not be transmitted in sufficient amount to cause fracture of the base. But if the weiirht and momentum of the falling body were in 12 194 FRACTURES OF THE SKULL. Fig Fracture of Base of Skull from Fall on Vertex. excess of the expenditure of force in causing fracture of the vertex, the impulse would drive the head down upon the summit of the spinal column, and fracture of the base would result ; in that case, viewed mechanically, the lower fracture would be succes- sive to the upper. But if the falling weight which struck the vertex were of a yielding material, fracture, if any, would be in the base, and not of the vertex, because the vis iiierfia of the skull would be overcome, and it would be driven down upon the spine without the application of circumscribed force to the vault. The same reasoning applies when fracture of either the vault or base, or of both together, is the effect of a fall on the vertex ; or this result may be varied by the blow being received on the forehead or occiput, the anterior or posterior divisions being thin and severally more ob- noxious to fracture." Injuries to the occiput are commonly followed by longitudinal fracture of the base, involving both the posterior and middle fossae. Injuries to the temporal region or about the ear are followed by fracture of the petrous bone and the middle fossa ; they are always serious. But it is rare in diffused injuries to the head to find one fossa alone involved : fissures generally pass through two fossae and extend from the vault or part struck. The evidence afforded by my notes of two hundred cases of fatal head injuries clearly establish these points, which have also been experimentally proved by Dr. Aran. " In precipitating a large number of bodies. from various heights on to the head. Dr. Aran found that the part of the vault which first struck the ground gave, as it were, the key to the fracture which would take place at the base. Similar results were also obtained when diffused blows were dealt upon different parts of the skull by means of a large and heavy hammer. In the front part of the vault injuries thus produced led to a fracture of the anterior fossa, in the middle part of the vault they led to a fracture of the middle fossa, and at the back of the head to a fracture of the posterior fossa. In no single instance was a fracture detected at the base without a line of fracture in the cor- responding part of the vault. The truth of this has been proved by an analysis which I made of all the cases of fractured base of the skull admitted into St. George's Hos- pital during a period of ten years " (Prescott Hewett). My own observations go entirely to prove the correctness of tlaese views. The mid- dle fossa is the one, however, most frequently involved. Compound fractures of the skull are, as a rule, local fractures. They are gen- erally the result of a concentrated blow upon, or a puncture of, the part, the force employed having been expended in producing the local injury. They are, consequently, often starred or comminuted and depres.sed fractures. When the brain is involved in the injury, it is chiefly beneath the seat of fracture ; it is rarely shaken or concussed as much, as it is in simple fractures the result of a diffused blow. The dangers attending a compound fracture do not, therefore, arise so much from the direct injury to the brain as from secondary intracranial inflammation the direct result of irritation of the dura mater by the depressed or comminuted bone, the dura mater being frequently punctured or torn and in all cases irritated by the depressed bone. These facts have an important bearing on practice, since they encourage the surgeon to remove the depressed and irritating portions of bone, which have such an injurious influ- ence on the progress of the case. When the brain is injured by the accident, the danger is far greater. THE DIAGNOSIS OF FRACTURE OF THE SKULL. There are no special symptoms by which a fissure of the vault uncomplicated with a wound can be recognized. The best guide to the diagnosis of a fracture of the skull is the nature of the injury. Extensive fractures of this kind are constantly found upon the post-mortem table where no suspicion of their presence was entertained during life. Tin: /)/ K/.vo.sY.v OF rn.Krrni-: of the skull. 195 Wtiin :i wuiiiiil complicates the ca.sc, a iVacliiii" can usually be made out, as the fissure can l>c seen as a red line. ('ar(>, however, slioiijil lie taken in these cases not to mistake a auturi' for a fracture. When depressed lione exists with I'ractiire, the dia;;nosis is rarely difficult, unless it should so happen that the fracture has taken jilace hcneath the body rd" the temporal imisele, when it is almost impossilile to diaLTUose its existence by direct signs. An efiusion of blood beneath the pericranium may be mistaken for a fracture with depressed boiu', unless care bi' observed, as may a natural depression in the skull, [lar- ticularly in the occipital rt>i;ion. Fracture of" the skull the result of a jnnicfiiml wound can, as a rule, be reailily recog- nized, thouuch when the point of the perforatiiiL: instrument has been broken short off at the surface of the bone much care is needed. T/ir (h'lii/iiiisis of n frticlnrv of tftc haur, or of the base and vault combined, is always a source of difficulty, since there are no signs, but only symptoms, to assist ((pinion. The nature of the accident is without doubt the surgeon's best guide ; a fall from a height or a heavy blow ujmiii the head is the usual cause of such an accident, though a crushing force ap]died in any direction may produce the same result. Should the fall have been upon or the force applied to the vertex, the middle fo.s.sa of the skull will probably be the seat of injury ; and the diagnosis of a fracture through the petrous bone may with some confidence be made when such an injury is followed by profuse or ])ersistent hemorrhage from the ear, succeeded by the copious discharge of a watery, and perhaps saccharine or slightly albuminous, fluid, and jiaralysis of the parts supplied by the facial nerve. Slight hemorrhage from the ear is no po.sitive sign ; the moderate discharge also of a water}- fluid alone is not characteristic, nor is facial paraly- sis. But profuse and prolonged bleeding from the ear, or .slight hemorrhage, followed by a watery discharge, is, however, strongly indicative of a fracture, as is also a copious watery discharge directly following the injury. Facial paralysis, however, combined with either of these symptoms, renders the diagnosis complete. This watery discharge is now generally admitted to be an escape of cerebro-spinal fluid through a fracture of the petrous bone, passing across the internal auditory canal, and attended with rupture of the membrana tympani. I have known this to continue for eight days. In injuries to the mastoid process, if a local emphysema exists, the presence of a fi'acture may be diagnosed. Fracture of the Anterior Fossa. — Should the blow or fall have been upon the anterior part (d" the skull, the probaliilities of the case point to fracture of the anterior fossa ; and where any injury to any of the nerves of the orbit can be made out, as indicated by local paralysis of some of the muscles of the eye, or when hemorrhage has taken place beneath the conjunctiva, the diagnosis is certain. Hemorrhage into the eyelids by itself is of no value as a diagnostic sign, although when it follows the acci- dent at a later period and is consecutive to subconjunctival hemorrhage it is a symptom of some importance. Falls upon the occiput coniinonly produce longitudinal fissures of the base. Copious and obstinate bleeding from the nose or pharynx is by no means unfrequent in a case of fractured base, and when accompanied with other suspicious symptoms is of diagnostic value. I have the notes of a case of injury to the head in which the patient apparently died from bleeding from the nose and mouth, no blood coming from the ear; and after death a fracture of the base was foiind completely separating the petrous por- tion of the temporal bone from its connections and laying open the lateral sinus. The right tympanum was full of blood, but the membrana tympani was entire. The stomach was full of blood, the blood from the lateral sinus having apparently found its way through the Eustachian tube into the pharynx and stomach. I have also the particulars of a second case, in which the carotid artery was divided in its passage through the petrous bone and the lateral sinus laid open, the lungs and bronchial tubes being found filled with blood, even down to the air cells. Each of these patients lived only two hours after the accident. Fracture of the base unassociated with any injury to the brain itself is of no more conse((uencc than fracture of another part ; but as the base is the most delicate part of the brain, and any injury to it is sure to be followed by severe, if not fatal, symptoms, the subject of fracture of the bones upon which it rests becomes of proportionally greater interest. This fracture of the base may be associated with all the intracephalic injuries to which fractures of the vault are liable. It may be complicated with simple concussion 196 THE DIAGNOSIS OF FRACTURE OF THE SKULL. of the brain, or with the more severe form associated with laceration of the brain struc- ture, or extravasation of blood upon or within the brain itself. If blood is eflFused, there may be compression of the brain followed by death, or the same result may be produced by a secondary inflammation of the membranes and injured parts. It is difficult, upon the whole, to separate the two cla.sses of cases, inasmuch as the dangers arising from injuries to the skull do not depend upon the seat of fracture, but upon the injuries to the cranial contents ; and, as the same injuiies may be produced by, or rather ma}- be associated with, fractures of the base, the complications and dangers are the same in each. Having, then, so far shown that the dangers of all forms of fracture of the skull are really alike, and that the same intracephalic complications attend fractures, whether of the vault or of the base, I now proceed to illustrate the special symptoms generally regarded as being diagnostic of such injuries by a brief analysis of cases from my note-book. Among thirty examples which are there recorded, twelve were associated with .simple concussion, in all of which recovery took place. In three cases the fractures extended through the orbit, as indicated by subconjunctival ecchymo.sis. In eight there was hemorrhage from the ears ; in all, this was followed by a discharge of serum, and in seven of the cases it was associated with paralysis of the facial nerve upon the same side. In these it is quite fair to conclude that the line of fracture extended through the petrous portion of the temporal bone. In two there was bleeding from the nose ; in one there was a serous discharge from the ear. accompanied by paralysis of the facial ; in another this discharge followed hemorrhage from the ear and was unaccompanied b}' paralysis. To test the value of these different symptoms as indicating fracture of the base in various positions, the following analysis of the fatal cases will prove of value ; and, taking the symptoms separateh', subconjunctival hemorrhage will first claim our attention, as being one which more or less accurately marks a fracture through the orbital plate. In the eighteen fatal examples, this symptom was manife.sted in four instances, the line of fracture extending in each of these through the orbit. In two cases there was copious hemorrhage from the ear, while in both the fracture passed through the petrous bone. In three examples there was some epistaxis. In one of these the fracture extended across the ethmoid bone, in another the frontal sinuses were full of blood and fractured, and in the third the tympanum was found full of blood, the membrana tympani perfect, and upon careful examination the lateral sinus of the brain was found to have been lacerated. Seven of the eighteen fatal cases died from direct injury to the brain, the post-mortem examination in all revealing severe contusion or laceration of the brain structure, with effusion of blood upon the surface of the brain or upon the membranes. Seven other cases died from arachnitis as a result of the injury. In four of these there was contusion of the brain, and in one ecchymosis of the ventricles ; in two there Fig. 75. Fig. 76. "^?<=>> Fracture of Anterior Fossa of the Base of Skull. (Prep. No. 10858^, (Juy's Hosp. Mus.) a, Punctured Wound through Frontal Bone. 6, Portion of Wood which perforated Bone. (Prep. No. 1086M Guy's Hosp. Mus.) was no evidence of contused brain, nor was there any effusion of blood ; in one interest- ing case the inflammation spread from the internal ear. In three the cerebral mischief was complicated with some thoracic or abdominal injury which caused death, and in one hemorrhagre was the immediate cause of death. CONCUSSIOS OF THE IIHAIX, AM) ITS I! I' F i:CTS. 197 A sevcro hlow ii|miij tlic iioso, hy driving in the otiniutid horn-, may cause fracture of the uiitcriur fossa of the base* of the skull (riilr ]•'!•;. 7')), and 1 liavc had under my care several cases in wliicli a severe Itlow m|miii tlic jaw produced a fracture of the niiddh; fossa. At St. (JcurLM's Hospital there is a s|ii'ciinen in which a fracture of the base was caused hy ilif tondylf nf the hiwcr jaw hein;; driven aj^ainst the ;j;lenoid fossa with such force that the condyif proji-cted into the cavity of the skull, and in (luv's Ur)spital Museum there is a simihir specimen, whicdi was sent in with Mr. Hutchinson's prize essay. I'unctured wounds of the orhit arc; Ity no means infre(|uent causes of i'racture of the base ; many are recorded. I was once called to a case in which a lead-pencil had perforated tlii' l)one and the brain throuL'h the orbital plate, and Fijr. 7<> was taken from a preparation in which the fnnital Itoiie was perforated. The diu^'intsis of these ca.ses is not dillicult. When bruin matter escajies externally throu<:h the wound, there is no room for duulit. The treatment of fractures of the skull will be described after the subjects of injuries to the brain and extrava.sation of blood within the cranial cavity have been considered. CONCUSSION OF THE BRAIN, AND ITS EFFECTS. '• A man receives a blow on the head by wliich he is only stunned for a longer or a shorter period. Wiiat is said to have happened? Concus.sion of the brain. " A man dies instantaneously or lingers some time perfectly uncon.scious after an injury of the head; there arc no marks of external violence. Again, what is said to have happeiu'd ? Concu.ssion of the brain. " The head is opened, and what is found ? In one case no deviation from the healthy structure ; in another, simply great congestion of the cerebral vessels ; in another, numer- ous points of extravasated blood scattered through the brain substance ; in another, a bruised appearance in some parts of this organ. In all, the ca.se, in common parlance, is said to have been one of concussion of the brain. Such are the after-death appearances ascribed by different surgeons to concussion of the brain." These words of an eminent surgeon (P. Hewett) so accurately describe the ordinary teaching of the schools that I have transcribed them as a fitting introduction to the sub- ject of which I am about to treat. They arc likewise practically true, although expe- rience of the post-mortem room shows that in ca.ses of death from concussion of the brain, with the rarest exception, some changes in structure are to be found if carefully looked for, some bruising or laceration of the brain, some bleeding into its substance. In fact, death from concussion of the brain without change of .structure hardly ever takes place, concussion untl vontiixion of the brain being. ass away and leave no mark behind. Convulsions, when they appear in an adult, are symptoms of grave anxiety, since they almost always indicate brain injury and forbode mischief. When reaction is excessive, it is attended with symptoms of fever and brain disturb- 7:;a'77M r. I.S.I v'/o.v nr hlood as iii:sri/r of ('(jycfssioy. 199 aiit'O, siuli :is tlflirium, fxcilriiicnt, and coma. Tlw suhjijct lo\v, the hruisinir may he hut local ; yet it is more usual to find jhe opposite side of the hrain also hruisetl, hy what is riirhtly termed " contre-coup, " and. indeed, it very often hapitens that tin; mis(diief tis, partial or complete, of one or more of the cerebral nerves. This paralysis may be either a passing or a permanent symptom. Paralysis of the seventh pair, including the facial nerve, has been already alluded to as a somewhat typical symptom of fracture through the petrous portion of the temporal bone. This may appear as an immediate result of the injury, indicating laceration of the brain by the fracture, or, what is more usual, at a later date, when it .may be the effect of pressure by effused blood upon the nerve trunk in some part of its course, or. at still later period, by inflammatory effusion. On referring to my own notes of cases admitted into Guys Hospital at different periods during the last twenty years. I find examples of injur}" to the optic nerves, as indicated by blindness, paralysis of the muscles of the globe of the eye as a whole, and paralysis of the external rectus muscle alone. Paralysis of the facial and auditory nerves is very frequent, and at times there is paralysis of the fifth nerve, as indicated by com- plete loss of sensation of the face, etc. Paralysis of the hypoglossal has also been observed. In "the majority of these cases the symptoms appeared as a direct result of the injury; in some they came on two or three days later, associated with febrile symptoms, biit in most they disappeared in the course of a few weeks. In some instances, however, of facial paralj'sis the symptoms were permanent. In all these there must have been injury to the base of the brain. " The coexistence of hemiplegia on one side with paral- ysis of the third nerve of the opposite side is indicative of lesion of the crus cerebri on the side on which the third nerve is paralyzed " (Le Gros Clark). I had once under my care a man who received a severe blow on the left side of the head, above the ear. The injury was followed by symptoms of concussion, which soon passed away ; but he had complete aphasia. In the course of a few days he partially recovered the ability to speak, but then spoke so thickly that he was unintelligible ; in about three weeks he could be understood, but he did not recover his natural powers of speech for at least three months. During the greater part of this time he was subject to headache, which the least exercise or excess in diet made wor.se. There can be little d(»uV>t that in this case the base of the middle lobe of the right side had been contused. Mr. Callender' tells us " that symptoms of aphasia are more apt to follow injury of a part of the left hemisphere outside the corpus striatum than any other part, that injuries to the right hemisphere are more rapidly fatal than are equal injuries to the left, and that the right-side brain lesions are more often as.sociated with convulsions than are similar hurts at the opposite side." The evidence of these opinions is not strong. Remote Effects of Head Injuries. There are. however, many injuries to the head which, without producing such definite symptoms as have been described as the result of concussion, etc.. yet cause .serious and often permanent damage to the patient. The effects of a blow on the head are by no means to be determined by the immediate symptoms that result, for a person may receive a trifling or severe injury, from which he is supposed to have completely recovered, and yet the case may end in a permanent enfee- blement of the mental powers or be followed by paroxysms of uncontrollable excitement. It behoves the surgeon, therefore, to be mo.st cautious in giving an opinion as to the issue of a case of injury to the head. Insanity. — The records of lunatic asylums and convict prisons prove unhappily, that many cases of apparently trivial injury to the head, unaccompanied by .symptoms which would indicate any positive affection, such as concussion, paralysis, etc.. have ended in an affection of the brain which has rendered the patient hopelessly demented or a criminal, and. moreover, has left no visible traces of the malady in the brain after death. The following may suffice as illu.strations : A boy aet. 16 fell from a tree and was found partly insensible. After a few days' treatment he was dismissed from the hospital as •' cured." In a few months he was obliged to be placed in a lunatic asylum, where he remained several years. A gentleman put his head out of the window of a carriage while travelling by rail- way, and received a scalp wound from striking against a post. He was rendered insensi- ^Brit. Med. Jour., June 6, 1874. i\.iri!i/:s or rur: /.•//. i/.v <(imi-li<- \risi; FiiAcrriu-:. -joi l)I(' at tlic liiiif, liiit smiii iiii|ini\ ('(1. Tin re were no si<:iis of iiii|i(iihiiic(', vt in a l"<'\v WCi'ks ho was in a state ot' inc-ntal ulirrratiori, aiitl ilit-cl in a year. A man was kicki'tl l»y a liorse in tlie stomach ami fell, strikinrrhaire Upnn tlir siir/drr >>/' tin- Innln is a very important siihject, occurriuL' in variable detrrees in every case of severe or jreneral in- jury to the skull, whether complicated or not with fracture ; the hrain'itself may be not only brui.sed at the .seat of injury, but it will be etjually. if not more, injured at the opposite pitint bv coiifff'-roii/i. and this Ijruisintr and ex- travasation is irenerally found at the base of the brain. The hen»orrhai.1i!ical Mprliciiv, December, 1875) telLs us thit out of 1240 post-mortem examinations made at the West Riding A.sylum there were 51) examples of arachnoid cysts — 48 occurred in males. 16 in females — and the majority were in the left side. In half the cases general paraly.sis was the cause of death. Dr. Browne does not think that these cysts have a traumatic origin, but are due to the rup- ture of a vessel from cerebral hyperajmia. To Sir Prescott Hewett ( Med.-C/ii'r. Tmns.. vol. xxviii.) must be assigned the credit of explaining how these cysts are formed from a chronic change in previously effused blood. For a full elucidation of the subject, however, we are indebted to Drs. Wilks, Ogle. Bacon, and Sutherland (^Journal of Mental Science, vols. x. and xi. ; Bep. ^yest Riding Aai/htm. vol. i.). 204 COMPRESSION OF THE BRAIN. COMPRESSION OF THE BRAIN. The brain may be compressed in many ways, though there are four special causes of compression : Compression from " depressed bone." the resuh of fracture, simple or com- pound ; compression from the '-extravasation of blood" into any part of the cranium; compression from the ^^ formation of matter'' between the dura mater and the bone; and compression from the "effusion of injiammatori/ protfucfs' into the brain or its membranes. The .symptoms of compression' under all these different circumstances are much alike, although the clinical history of the cases and the date of the appearance of the symptoms after the injury vary in each class. When the symptoms are due to depressed bone, they follow immediately the accident. When caused b}" extravasation of blood, there is almost always some interval of time between the accident and the accession of the symptoms, although that interval may be but short. When caused by the effusion of inflammatory products into or on the brain, the symptoms generally appear some days after the acci- dent and are gradttal : and when the result of the formation of matter between the dura mater and the bone, the symptoms rarely show them.?elves for two or three weeks after the accident. In both of the latter classes of cases, morepver, headache and other inflam- matory symptoms coexist. The si/mpfoma of comjrrension of the brain are those of apoplexy, and their severity depends entirely upon the suddenness and amount of the compression. The skull may be fractured and the bone depressed, and still no symptoms arise. Extravasation of blood may also take place to a limited degree within the skull and not be recognized. There is good reason to believe, indeed, that a considerable amount of blood may be poured out sloxdy upon the surface of the brain without giving rise to compression, the brain gradu- ally accommodating itself to the pressure. The most marked cases of compression are usually due to rapid extrava.sation. When the bones are much depressed, or when the brain is saddeidj/ compressed by the local effusion of blood, symptoms show themselves, such as complete insensibility, slow. diflBcult. and perhaps stertorous, respiration, and a full, slow, laboring pulse. In very severe cases the respiration will be of a peculiar p^iffing character. There may also be complete loss of the power of swallowing, inability to retain feces, and retention of urine, incontinence or overflow of urine being the last symptom. The pupils may be either dilated or contracted, but they will be always fixed, and will not respond to light : whereas in alcoholic coma. Dr. ^lacf^wen tells us. •* the pupil is contracted when the person is left undisturbed, and it is dilated when an attempt is made to rouse him " ( GJnu'ion: Jonrvol. January. 1879). When the brain is widely and uniformly compressed, the symptoms are '' general " — i. e., one side is not more paralyzed than the other. When the compres.sion is localized.^ the paralysis is partial and corresponds with the region affected, though when extravasa- tion is extensive the general effect may mask the local symptoms. The best examples of this form of limited compression are found in cases of fracture of the skull from a local injury and extravasation of blood between the bone and the dura mater. The case quoted on page 202 is a good one in point, though the following is probabl\- a better, as it is complete : J. P , aet. 46, a painter, having fallen from a height upon his head on a piece of iron, received a severe scalp wound on the right side of the median line of the head, with slight concussion. He was admitted into Guy's under Mr. Cock's care in 1841, con- scious, and remained so for eleven hours ; four hours later, however, he was found in a state of utter unconsciousness, with stertorous breathing and insensible pupils. He con- tinned gradually to get worse. The left arm and leg when pinched were readily retracted. The right side was completely paralyzed. No fracture could be discovered. Trephining was performed above and behind the anterior inferior angle of the left parietal bone over the trunk of the middle meningeal artery ; a large piece of bone was removed. A gush of blood then took place, and a large coagulum was removed from outside the dura mater. The deep stertor at once ceased, and the next day the man moved his right arm and leg freely and recognized his wife. He progressed favorably after the operation, though recovery was retarded by bone exfoliation. He resumed his work and occupation, and continued in good health for thirteen years. During this period, however, he had at inter- vals exfoliation of some portion of the skull at the seat of injury ; in the ninth year he had fits, which during the last six years of his life recurred at intervals, the attacks, as Mr. Cock reported, becoming gradually more frequent and severe in their character. Six months before his death he had paralysis of the opposite side of the body to that of the injury ; the face was included in the paralysis, and his speech was somewhat affected. COMI'liKSSloX OF Tllh: HUMS. 205 lie (lioil af'tor II severe miopleetir lit. Alter dcatli tin- ))raiii )»ftii;atli the iiijiireil l)i»ne was foiiml snf'teiuMl and aillien-iil tu tlw nkull, ami it cuiitaiiM'd a recent clot of thniti or four ounces ttf hlooil, which liMcil tlic ventricles. • it appeared prohahle," ways Dr. Wilks, who math' the c.\aniination. "that a softeiiin^^ had hecn ;;oinjr on for .some months in the middle lii-niispherc of the hrain, involvinj; tiic contij;uous surfaces of the corpus striatum and thalamus, and that at last a rupture ^^' the V(!S.sel had taken place, intiltratinj: all these disi-ased structures, as well as the ventricles." The trephine opening: was tilled in liV a touirh niemhrane, and around its inarL'ins then,' was evidenci! that cousiderahle ostitis liad taken place (Cock, (lui/'s J/osji. liijunts, \s7u ). When a patient receives a direct hlow u|>nn oni- siile of the head, causing; a fracture with depression of the hone, and attende(l with |)aralysis of the opposite side of the hody and a tixt-d and dilated pupil on the side of the injury, the conclusion is int.-vitahle that the depres.sed hone is the cau.se of the paralysis hy producin;.' ])ressnre upon the hrain : the dejircssion must, however, he very •j;reat to f::ive.rise to sucdi symptoms. When a patient sustains a similar injury, with or without depression of the hone, hut followed after a distinct interval of time hy paralysis of one side of the hody, whether of the injured side or not, it is (juite fair to assunu- that hemorrluifre has taken place inside the skull and is the cause of the compression. In both these ca.ses a local injury is followed hy local mischief, causinir a local paral- ysis ; consequently, surjiical treatment is of i.rreat promi.se. When a patient receives a <^encral injury to the head — such as commonly results from a fall ui)on tlic head from a height or a diffu.sed hlow from a heavy falling body — and this is followed directly or after an interval of time by symjitoms of compression, whetlier a.ssociated or not with a fracture, the paralysis is, as a rule, ireiieral ; and even if more complete on one side than another, the injury to the brain is, for the most part, too dif- fused or extensive to admit of surgical relief. The case is clearly of a mixed nature, contusion or laceration of brain structure being a.ssociated with hemorrhage. Symptoms of Brain Injury. — When a patient suffering from brain shock, with or without a fracture, is unconscious, motionless, and perhaps pulseless, has lost control over the action of the bowels and the bladder, and has a feeble respiration and paralyzed pupils, it is impossible for the surgeon to form any opinion as to the nature of the cere- bral injury. These symptoms may be the result of so-called concussion, from which recovery may take place, and not of severe brain contusion ; they may be associated with bruising of the brain and extravasation of blood — not sufficient, perhaps, to cause fatal compression of the brain structure, but enough to set up cerebral symptoms, which cannot pass away for many months under the most favorable conditions ; or they may be accompanied by severe brain laceration or extravasation of blood upon or into its struc- ture, which wiil prove fatal by coma. The position of the extravasation has no influence on the symptoms, although it would appear that death is very rapid when it takes place into the ventricles. The primary symptoms of severe concussion and of general com- pression are identical, and are often not to be distinguished ; both may be the result of the same kind of accident. '■ But," says P, Hewett, " there is this marked difference : in concussion the effects are instantaneous, and in compression from extravasated blood some little — it may be very short — time elapses before the symptoms manifest them- selves. In the former, also, the symptoms gradually pass off, but in the latter they become more and more marked." '• The symptoms of concussion may be continued or renewed either by extravasation of blood, pus, or both" (John Hunter, MS., 1787). '' The diagnostic .signs of concussion and compression are, no doubt, distinct in a certain sense, yet compression rarely exists as a consequence of violence without concussion, and both are complicated with shock. Further, symptoms of simple concussion may become developed at a later period into those which indicate some more serious le.sion ; and it is in exceptional cases only that we can identify with any degree of certainty the efficient and sole cause of compression. Thus, in the stunning effects which succeed a blow on the head, if we can rouse a patient from his state of unconsciousness, even for a few moments, if the breathing is calm and noiseless, if the pulse is feeble, the pupils are contracted, and reflex action can be excited, we conclude that the condition is one of concussion. The intensity of the effects of so-called concussions are marked by the character of the symptoms and by their duration. The probable explanation of pro- tracted somnolence and other evidences of brain disturbance is the presence of diffused extravasation of blood over the surfiice of the hemispheres " (F. Le Gros Clark). Hemorrhage into Brain with Fracture. — Again, in a general shaking of 206 WOUNDS OF THE BRAIN. the brain, blood may be extrava.sated into the brain itself; and when the injury has been sufficient to produce fracture, there is no limit to the amount of hemorrhage or its seat. " But in dealing with such cases great caution is necessary in order to avoid, if possible, mixing up cases of apoplexy with those of traumatic effusions. An accident coexisting with an extravasation of blood into the cerebral substance does not necessarily imply cause and effect. The previous condition of the brain or the outpouring of blood from diseased vessels may, in fact, have been the cause of the accident" (Hewett). On referring to my notes, I see that in a case of brain injury which lived only one hour blood was found filling the ventricles. In another the ventricles were bruised and the septum lucidum lacerated. In other cases blood was poured out into the thalamus opticus or into the corpus striatum. In all these the brain had been severely shaken, the hemorrhage being doubtless the result of the shake and the cause of death, while the fracture of the skull was merely a complication. General Summary. — It has been already shown that concussion of the brain too often implies contusion or laceration of its structure, with extravasation of blood, and -in the same way compression indicates as severe, if not more severe, injury. Concussion does not by itself produce definite symptoms ; and when paralysis, vertigo, sickness, or other such phenomena, arise, the inference is that there is some structural damage to the brain. Compression implies a more severe degree of the same sort of injury, with effu- sion of blood or depression of bone. Compression of the brain, when not excessive, is seldom the durct cause of death. It proves fatal in the majority of cases by being the starting-point of an intracranial inflammation, since it has been proved that blood can be absorbed or encysted and depressed bone may be gradually raised by the brain itself, or the brain may accommodate itself to the pressure. Compression of the brain as a' result of traumatic encephalitis will receive attention in a subsequent page. Wounds of the Brain. In some injuries to the skull the brain may be wounded or lacerated, and brain matter may even escape from the wound directly after the accident. Such accidents are always of a very grave nature, and, as a rule, fatal. Wounds of the anterior and upper portions of the hemispheres are the least dangerous ; wounds of the posterior hemisphere or base of the brain, the most so. Recovery may, however, at times follow very severe injuries when no secondary inflammation takes place. When brain matter is pressed out of the skull in cases of fractured base, a grave injury is always indicated, since the crushing force must have been severe to have given rise to such a complication. Some remarkable instances of recovery after the escape of brain matter are, however, i-ecorded; and several have passed under my own observation, but they are too rare to be dwelt upon as holding out any hope in bad cases. Foreign bodies may like- wise lodge in the skull for a long period without causino; death. Wounds of the brain are not cluiracterized by any special symptoms apart from those of concussion or compression. Wounds of Dura Mater.— Wounds of the dura nuUer are pr()l)ably as dangerous as wounds of the brain, for inflammation of the membranes is readily set up by such injuries. It is from this fact that compound fractures of the skull are so serious, that simple frac- tures associated with comminution of the inner table of the skull are so often fatal, and that punctured fractures have so dangerous a tend- ency ; for in all these cases the dura mater is not oidy torn, but irritated, by the pro- jecting spiculae of bono, and secondary inflammation is the result. This inflammation, as a rule, rapidly spreads over the brain and causes death. Prognosis. — Wounds of the dura mater, as well as wounds of the brain, are some- times recovered from, but the prognosis in either case must be unfavorable. Hernia cerebri, or protrusion of brain matter alone, or brain matter mixed with Fig. 79. Hernia Cerebri. ENCEVUM.ITIS. 207 inflaiiim.itDry priMliicts, is always tlic result ni' ;i wiiiiinl nr s](iii<:h of the iliira mater sectmdarv citluT ti> a n)ni|Mimnl t'ractiin' (»r to tin- rciimval nl" }'ractur('d. Scitticr for July, IST.'K five otlier instances may be referred to in which success f(dlowed this practice. Dupuytren had a successful case of the kind, and pathological anatomy furnishes exam- ples in which such a practice might have been of use. On the other hand, many bold attempts are on record in which surgeons have punctured the brain to relieve symptoms of suspected suppuration in its substance. Weed's case is without doubt the best, as it was successful (Nashi-i//'' Journ. Med., April, 1872), but Detmold's and Maisonneuve's are encouraging. I am disposed to think that surgeons are too apt to leave these cases alone too long and allow them to get beyond relief. A man receives a blow upon the head, followed by passing symptoms of .so-called con- cussion ; he has a slow convalescence, attended, and perhaps followed, by headache. He may display some irrital)ility of brain, inability to do much work or to undergo any phys- ical fatigue ; some febrile disturbance may perhaps manifest it.self, but a.s often as not none appears. The pulse probably will be feeble and irritable, at other times slow and hi))oring. On examining the seat of injury tenderness on pressure may be experienced, and occasionally increase of heat will be felt. Pressure upon the injured part may even excite a convulsion where such had previously occurred. Under these circumstances, which are fairly indicative of local inflammation of the bone, spreading inward — though how far is uncertain — a free inci-sion to the bone is of great value. I have known this operation relieve immediately all the symptoms, general and local, and have never known it followed by harm. It should always be performed when evidence of local inflammation exists, with umlefined and persistent brain svni]itonis. Symptoms of Abscess beneath Bone. — When, however, evidence exists that the inflammation has spread from the bone to the ])arts beneath, as indicated by symptoms of feverishness, severe headache, and probably rigors, with sleeplessness, delirium, con- vulsions, and paralysis, particularly when hemiplegic. other surgical treatment may be thought of; for if these sym])toms are associated with such a history as has just been sketched, there is every probability that suppuration exists within the skull and that sur- gical art may reach it. General treatment, moreover, in these cases is both unsatisfac- tory and unsuccessful ; and if the case be left alone, bad results always follow. Surgical interference, it is true, as a rule, is not very .satisfactory, though some striking examples of success exist. In the hands of Pott trephining the skull for matter beneath the bone outside the dura mater yielded a good result in five out of eight cases. No modern sur- geon, however, can show a like success; '"indeed," says Sir P. Hewett. "the successful issue of a ca.se of trephining for matter between the bone and dura mater is, I believe, all but unknown to surgeons of our own time.'' Xevertheless. the operation is clearly justi- fiable under such severe circumstances as have been described : for our want of success is probably due to the fact that surgeons are too readily disposed in these cases of local encephalitis to wait too long, to trust too far to natures own processes, and by so doing to allow the local suppurative action to spread inward beyond the dura mater to the brain itself, when the prospects of a successful result are certainly poor. They wait for what are called well-marked brain symptom.s — coma and hemiplegia — before they interfere ; which well-marked symptoms too often mean fatal brain complications. Trephining the seat of injury, therefore, under such circumstances is clearly a justifiable, if not a hopeful, measure, should the operation be performed as soon as it is manifest from the history of U 210 TREATMENT OF CONCUSSION. the case that the local action is spreading. When pus is found between the bone and the dura mater, great hopes may be entertained of a successful issue, although, when the same suppurative "action has involved the cavity of the arachnoid and the brain, the prospect is not good. Should no pus be found, however, between the bone and dura mater, is the surgeon justified in opening the membrane? Without doubt he is when there is strong reason to believe that pus exists, when the dura mater on exposure hubjcs firmly into the opening in the bone which has been made with the trephine, and is tense as well as absolutely puhr- lesa; for cases of success after this operation have been recorded by Guthrie, Ptoux, Dum- ville, and Hulke. The evidence required to sanction any incision into the brain in search of suppuration, as has been already stated, must be very strong. Acute encephalitis as a result of blood poisoning needs only to be mentioned. It is a hopeless condition from the first, and is always associated with the worst and most general form of pyaemia. TREATMENT OF CONCUSSION AND COMPRESSION OF THE BRAIN, AND OF FRACTURES OF THE SKULL. "A mere crack in one of the bones of the cranium, ahstractedli/ consuhrcd. is not more likely to produce any serious complaints than a simple fissure in any other hone ; and if symptoms of consequence do frequently attend the accident, they proceed either from the bone being beaten inward, so as to press upon the brain, or from the mischief done to the parts within the skull by the same force that broke the bone itself. The same violence which breaks the cranium may occasion a concussion of the brain, an extravasation of blood in or upon it, or subsequent inflammation of that organ, and its usual consequences" (Sam. Cooper). ■ The truth embodied in this extract renders it necessary to consider the treatment of head injuries as a whole, since it is impossible to say. in any case of severe injury to the skull, whether two or more of the conditions mentioned are not associated. When brain concussion has taken place, it may or may not be associated with fracture, and it may or may not be followed by symptoms of compression, either from extravasation of blood or secondary inflammation ; and when a fracture is known to exist, either with or without depression of bone, the difficulty is not lessened. The symptoms may be a mere temporary suspension of the brain's functions — or. as they are commonly called, those of a passing' concussion — or they may be of a much more serious nature and such as indi- cate brain contu.sion, laceration, or blood extrava.sation. The severest complications are often ushered in by the mildest symptoms, and therefore the surgeon should always treat every case of injury of the cranium and its contents as serious. He should also be as guarded in his prognosis as he necessarily is uncertain in his diagnosis. In any case, therefore, of concussion, however slight, the patient ought to be kept quiet, and should observe moderation in diet, take little or no meat, and avoid all stimu- lants. If he moves about, it is at a risk — a risk of fatal secondary inflammation of the shaken or bruised brain. These precauitions should be continued for at least three weeks. In severer concussion, in which, after an injury to the head, there is a more or less complete suspension of the functions of the brain, whether with or without a fracture, equal care is needful. Should the collapse indicative of the first stage be severe, reaction may be hastened by means of warmth to the body generally, more particularly to the feet, and by the application of some stimulant to the nostrils. It is seldom right to do more than this, because, if reaction does not set in naturally and is not hastened by the means mentioned, it is tolerably certain that the brain mischief is of a severe, if not fatal, character. Under these circumstances, any more powerful means, such as the adminis- tration of alcoholic stimulants or powerful enemata, are likely to excite reaction to excess and either encourage secondarv hemorrhage or inflammation within the skull. Reaction and its Treatment.— When reaction has set in after the collapse— the second stage of authors — every source of excitement, mental or phy.sical, should be removed. The patient should be kept in bed with his head raised and shaved, and the bowels emptied with a mild saline or mercurial purge. Leiter's coil (Fig. 9), cold lotions, or an ice-bag .should be applied to the head, and particularly if it be hot. the pulse rapid, and other symptoms of general febrility and brain excitement show themselves. When the symptoms of excessive reaction are persistent, the commencement of traumatic encephalitis should be suspected ; and under such circumstances venesection, boldly performed, is a valuable remedy. It may even be repeated should the symptoms return and the pulse TIlKATMF.yr OF COMrRKSSfOX. 211 * ami tfiiipfratun' rist-. In fcrMo jcitii'iits. IidWcvcr, lilci'diiif: is inadmissible, ami umlcr all i-ircuiiistaiu-rs it oiitrlit only t(» In- resorted to after careful eoiisidoratioii. The diet should ln' li(|uised fracture of the vault or fracture of the base is to be treated upon like principles and with e(|ual persistency and care, for simple fractures of the vault, compound fractures of the vault, and simple fractures of the base, or of the vault and base combined, ituttssociated with t/ixji/tiretjient, require no special treatment beyond that indicateil by the l)rain symptoms. It should be here .stated that the treatment of all the.se conditions is to be continued f(»r at least a month or six weeks after the injury, since there are many cases on record in which sec(mdary inflammatory .symptttms appeared at least a montli after the accident or after the suli\' tlie primary symptoms. Treatment of Compression. — When the brain symptoms fidlowint: an injury to tlie liead partake more of the nature of compression — that is, when they are persistent in their character, and, instead of iroiiiK on toward recovery or to the restoration of the natural functions of the brain, tend rather toward their more complete abeyance — other <|uestions of treatment come before the surgeon ; and the most important has reference to the fact whether surgical art can do anything toward relieving the condition. The student who has carefully read the remarks that have already been made can now understand, when the injury to the brain or skull has been the result of some (j'-ueral iiijnn/. such as a fall upon the head from a height or a blow from a heavy body, that the brain mischief which follows is certain to be of a general character; and when sj'mptoms of local mischief complicate the case, little good is to be gained by treating these local symptoms when others of a more general or fatal character exist. In examples of brain or skull injury, therefore, as a result of diffused or general .shaking of the head and its contents, local interference of any special character is generally useless. In hcdf injuries, however, the question may be seriou.sly discussed. In cases of dt-prrssed fracturr^ ought the bone to be elevated? and should the fact of the fracture being compound influence the decision? I have no hesitation in answering both questions and asserting that in neither instance ought surgical interference to be adopted as a rule of practice, since experience has taught us that depressed bone jier se may exist to a great degree without giving rise to any serious brain complications, and that when even brain symptoms follow as an immediate result of the injury they may all pass away. Extravasation of Blood between Bone and Dura Mater. — Should, however, the symptoms indicate the ]>resence of effused blood beneath the fracture suf- ficient to cause compression of the brain, as shown by the lapse of an " interval of time " between the accident and the symptoms, and should local paralysis point out its seat, surgical interference is called for ; and in both simple and compound fractures the trephine may be required in order to elevate the bone. The operation is necessary on account of the brain .symptoms present in the case and has no reference to the character of the local injury — to the presence or absence of a scalp wound. In cases of simple fracture in which brain symptoms exist a free incision down to the injured part for purposes of exploration is often called for. In compoiiiid fracture of the skull, however, associated with depression and commi- nuti'iu of the bone, both with or without brain symptoms, the surgeon ought to remove loose pieces of bone and may elevate the depressed portions when this can be done with the elevator without difficulty, as splintered bone is always a dangerous body when in contact with the dura mater. When the brain is injured, the same course should be followed, the greatest care being observed not to add to the irritation by any rough manipulation. Should difficulty be felt, however, in removing bone, it had better be left in sifii rather than by inter- ference incur any extra ri.sk of injuring the brain or its membranes. Should there be. on the removal of Vione. severe hemorrhage from a meningeal artery, the piece should be left ; and should this practice fail to arrest the bleeding, a small piece of sponge or plug of carbolized catgut in,serted beneath the bone may succeed, or the ajiplication of a pair of spring forceps may be called for. It is not often, however, that such a complication is met with. In every case of punctured fracture of the skull trephining should be resorted to. 212 TREPHINING FOR HEAD INJURIES. General Summary to Surgical Interference. — It thus appears that in sim- ple or compound unamiminuttal depressed fracture from a local injury operative interfer- ence is not called for unless associated with marked symptoms either of compression of the brain or extravasation of blood between the bone and the dura mater ; whereas in compound commiuided fracture and m punctured fracture, with or without symptoms of brain compression, the bone should be elevated and all fragments removed. In other cases, as in fracture of the base, no surgical interference can be justified. Did space permit, many instances might be quoted to illustrate these points, for cases of fracture of the skull with depressed bone without brain symptoms in which recovery has taken place are numerous ; indeed, experience has proved that there may be much depression of bone without brain symptoms, and I am tempted to believe that depressed bone by itself never gives rise to marked symptoms of compression, and that when these are present hemorrhage exists with it. Many cases might also be quoted illustrating the value of surgical interference in compound fractures with depression ; I give the following : Compound fracture of skull with depression from local injury. A feeling of perma- nent weight on the head was the only symptom, which was at once relieved by removal of the bone, and recovery followed. Compound fracture of skull with depressed bone from local injury. Constant vomit- ing and pain in the head, which was relieved at once by removal of the bone, the patient recovering on the fourth day. Compound fracture of skull with depressed bone from local injury. Persistence of symptoms of oppressed brain. Elevation of depressed bone, and rapid recovery. THE OPERATION OF TREPHINING OR FOR THE ELEVATION OF DEPRESSED BONE. "Much has been written and said on the treatment of injuries to the head, and the result of modern experience and judgment has so far altered the practice of our prede- cessors as to render us cautious of inflicting an additional injury on our patient for the sake of gratifying an impertinent and useless curiosity as to the exact nature and extent of the original lesion." Thus wrote my colleague, Mr. Cock, forty years ago; and what he then said is true now, although, perhaps, surgeons at the present day are less disposed to trephine in head injuries than they were even at that time. At Guy's Hospital trephining and elevation of bone for bead injuries have been performed in fifty-one cases during seven years, and of these only twelve recovered. At Fig. 80. Fig. 81. Fig. 82. Showing the Operation of Trephining. A, Trephine prepared for use, with centre pin clown. B, With centre pin withdrawn, the outer table having been divided. Elevator. Hey's Saw. St. Bartholomew's Hospital it was recorded by Callender in 1SG7 that the operation had not been performed for six years. At University College, Erichsen gives six cases of recovery out of seventeen. The operation is, however, valuable in two classes of cases: Tin: <)ri:i:.\ri()S of i/nriiiMNa. 213 First. To relieve e(im|ire>si()ii dl' tlie Inairi iliie to either depres.sed hone or exlravasa- tiuii of blood. SiToiuUi/. To j)rcvi'iit, ehock, or relieve initalidii nl' tlie Inaiti or its uienibratics when caused by (1 ) depressed and coiiiiiiiiiuted boiie, by ( '1) iiifiaiiied and .swollen bone (whether the result of aeeident or disease), or by (!>) an aectiinnlation of pus Itetween the bone and dura mater eonipressini; the brain ; and it may be stated at onr. Mclitcriltcr^' has roconlud a case in the Tnniftfirh'iiiiH nf tin PuthnUxjlritl Sorlrtif^ vol. xviii., in which the tumor was haii^'iuc out of tlie ehihl's imiiitli and (•nimiimiicalinic with the .-l^ull thrmiL'h an o[M'nin;i- in front of the seMa turcica. Varieties. — In ii inniinijiii; h the incmhranes may protnich' as a whoh-, hut sometimes the dura niatcr ah)ue projects (c/iA I'rcp. inti.")"", (luy's Museum). In the true inirji/ut- /iiri/f the hrain itself is pres.sed out of tlie skull into the J"'"- ^•»- external tuiiuu'. This was well .seen in a patient from wlutin the accompany inj; drawinj^ i^^^iC- H4) was taken ; the skull contained the anterior and part of the middle lobes of tlie brain, and the sac the remainiiif.^ portions. Via. 84. Meninpocele at Root of Nose. (Mr. Poland's case.) Meningocele. (Drawing 501'«', (iuy's Hosp. Mus.) The ventricles were likewise divided between the two. The posterior lobe.s were adherent to the membranes that formed the sac. In a hydnncephalocch', in additimi to tlie brain substance, there will be a portion of one or both of tlie ventricles filled with fluid. "An enceplmloci li\'' writes Sir P. Hewett (*SV. Georcfe'ii Ho!y reticct(Ml irritation set uj) by a local disease, is rarely ass(»ciated with any constitutional disturl)ance. and is. for the most ])art, cured on the removal of its cause. Varieties. — Tetanus is likewise generally as.sociated with some local source of irri- tati(Ui, sonic wound or injury, and is then called '•• frinniKitir.' When no external or visi- ble cause can be made out, it is denominated '' Uliopntliir." Wiieii rapid in it.s cour.se, it is called " tiriitt' ;" when slow, ••■ clironir."' The acute form is usually the re.sult of an accident, and generally fatal. The chronic is for the mcst part idiopathic and more curable. Infantile Tetanus. — Tetanus is met with in new-born infants, and is then known as tris)iiiis iKiaccutiniii or frdtmts infantum. It usually comes on the second week after birth, and may be so acute in its course as to destroy life in from ten to thirty hours, or life may be prolonged to eight or nine days. It is a common affection in the West Indies, aiul has been known to occur frequently in ill-ventilated lying-in hos])itals. Bad ventila- tion, conse(|uently. has been put down as one of its causes, the others being cold, exposure, internal irritation, ane;7/Metanus. It is most common after the more severe varieties of accidents, such as burns, compound fractures, and injuries to the fingers and toes, though there is no evidence to prove that it is more fre- quent after slight injuries to the fingers and toes than to other parts. Lacerated seem to be more frequently followed by tetanus than incised wounds, particularly in children ; but the state of the wound does not appear to have any influence on the disea.se. Seven years' experience at Guy's Ho.spital gives the following facts (Poland) : Tetanus occurred in 1 ca.se out of 1304 cases of major and minor operations. " " 9 cases " 594 " of wounds of all varieties. " " 1 case " 856 " of injuries and contusions. " " 3 cases " 456 " of burns and scalds. " " 9 " " 398 " of compound fractures. 23 3698 " or 1 in every 160 cases. Date of Appearance. — There is no definite period at which tetanic symptoms are prone to appear. When they set in soon after the injury, they are for the most part acute and very fatal ; after the lapse of three weeks, the chances of their appearance are very small. Acute cases, however, occasionally occur during the second week ; upon this point Poland gives us the following facts : 220 ON TRISMUS AND TETANUS. Of 277 cases, 130 began before the tenth day, and of these 101 died. " " 126 " between the tenth and twenty-second days, and of these 65 died. " " 21 " after the twenty-second day, and of these 8 died. In tetanus following exposure to cold the symptoms generally appear rapidly after the exciting cause, and with the same exciting cause similar results occur in the trau- matic form. Symptoms. — There are no general or local premonitory symptoms by which the onset of this aifection can be recognized, and the earliest indications of it>s approach are gen- erally a difficulty in opening the mouth and stiffness in the muscles of the lower jaw ; yet these symptoms may be so slight as to pass unheeded or be misinterpreted. When, how- ever, some rigidity of the muscles of the neck, throat, or abdomen can be made out and the first indications of the "tetanic grin," or risus sardoiiicii>' — which is caused by the drawing down of the corners of the mouth by the muscles of the face — are recognized, the diagnosis becomes certain. Difficulty in swallowing will then soon appear (any attempt to drink fluids exciting spasm of the muscles of deglutition, and often of respira- tion), with pain, due to spasm of the diaphragm, shooting through the body from the scrobiculus cordis. As the disease progresses the muscular system of the body generally will be more or less affected, and in different cases different groups of muscles will be involved. Those of the back are the most frequently attacked, and their contraction may be so powerful as to cause an arching backward of the frame, producing what is known as '■'■ opisthotonos.'" In rare cases the body is bent laterally or forward, the terms '■'■ jileurosthotonos''' and " emjirosthotonos " being respectively applied to such conditions. The muscles of respiration are. as a rule, affected in acute cases, and the chief danger to life consists in the severity of the spasms which attack them. When severe, the first spasm may be fatal and may occur at an early or at a remote period of the affection. In a case under my care of severe traumatic tetanus all the symptoms were disappearing and recovery was confidently expected, when, on the tenth day of the disease, the first spasm of the laryngeal muscles took place, which destroyed life. When the jaw is unlocked by a fepasm of the depressor muscles, the tongue is some- times suddenly shot out from between the teeth, and often wounded. Progress of Disease. — As the disease advances the jaws become completely fixed, and deglutition is then impossible. The spasms of the muscles of the frame become more intense and frequent and the powers of the patient rapidly decline. The pulse, which was rapid, becomes more feeble, while the expression of the countenance betokens agony of the body and despair of mind. The slightest manipulation or move- ment of the patient sets up a fresh spasm, and any emotion may do the same. The skin becomes bathed with a cold sweat; and if death is not caused by suffocation, exhaustion soon puts an end to suffering. There is rarely any fever during the whole course of the disease ; the bowels are always costive, the stools offensive, and the urine, as a rule, natural. The intellectual faculties of the patient almost always remain unimpaired throughout, while the senses are morbidly acute. Anything like delirium is rarely seen. Should the case tend toward recovery, the spasms will become milder in character and recur at longer intervals till they disappear. It should he rcmemhered ., however, that as long as the slightest evidence of disease exists a sudden sjJasni of the glottis may at any time destroy life. Diagnosis. — This should not be a difficult task, and in every instance of lock-jaw the possibility of its being the commencement of tetanus ought to be entertained. Local irritations, however, may produce a locking of the jaw more or less complete ; but such are never accompanied by uncontrollable spasm, as is the case in tetanus. To diagnose between tetanus and poisoning by strychnine may be difficult, the symp- toms of both being very similar ; yet in tetanus the symptoms are progressive, while in poisoning they appear suddenly in all their severity. In tetanus muscular rigidity is always present, and aggravated at intervals ; in poisoning there are complete intervals of relaxation of muscle. In tetanus, too, there is constant rigidity of the muscles of the jaw ; in poisoning, the jaw is never locked except during the spasm. These points of difference are sufficient to assist the surgeon in the investigation of a doubtful case. Again, hydrophobia and tetanus have been mistaken the one for the other; but any one who has seen the former disease could hardly fall into such an error. The peculiar restlessness of mind and body, the complete intervals of rest and absence of spasm, the peculiar aversion that is shown to fluid, accompanied by thirst — all symptoms character- ON TRTSMUS AM) TETASUS. 221 istic *>[' liydrophobia — are ciiouf.'!! to ilistiiit;uisli between the two. Nevertheless, it shniild hi' rt'iiu'iiihtTcd that Dr. J. W. Otrh-, hitc nf St. (Jeorge's, lia.s recorded a case of tetanus and h3eripheral nerves, by which the exalted excitability of the cord is aroused."' Treatment. — Every imaginable form of treatment has been employed in this disease with success, to be discarded in its turn for something new. No settled form of practice can consequently be laid down. Still, much can be done in guiding the patient through this disease, in keeping him alive, and in warding off death. To keep the patient alive the most careful attention to feeding is required, milk and concentrated liquid animal food being the best diet. If these can be taken in sufiicient quantities, no other mode of administration is required; but if not, they must be given as enemata every four or six hours, as the case demands. Stimulants must be used cau- tiously, though when the powers are failing they may be freely given. Upon this principle of practice quinine has been strongly recommended ; it may be given in full doses to an adult, such as five grains every three or four hours, and then increased, or in one large dose, such as twenty grains, to be followed by the smaller one. Among specific remedies that have been greatly vaunted, the Calabar bean stands foremost, and may be trusted; it should be given in full doses, such as half a grain of the extract every two or three hours, or one-twenty-eighth of a grain of its essential prin- ciple, eserine, increased to double, even the tenth of a grain. Camphor also recommends itself to our notice in doses of from five to ten grains. The woorara poison has failed in its purpose. The bromide of ammonium or potassium has, however, been administered with advantage. ' Bril. and For. Med. Reiieii: 1868. 222 DELIRIUM TREMENS. It was hoped that a valuable drug for this disease had been found in chloroform, but experience has not justified the expectation. The hydrate of chloral has now taken its place and been of some service. Demme has advocated with much success the use of the curara, eight cases out of twenty-two having recovered under such treatment. In India the Indian hemp has been highly recommended. Nicotine and tobacco have also been successful. Aconite is another drug that offers some advantages, while opium has an unquestionable influence in allaying pain and mitigating the severity of the spasm. Ice, also, applied in bags along the spine, has apparently been of great value in the hands of American surgeons. The administration of remedies by subcutaneous injection in these cases promises to be a valuable adjunct to practice, enabling us rapidly to introduce into the system drugs that act antagonistically to tetanic spasm. The patient should always be kept quiet, warm, and free from draught. He should, moreover, be so watched that in his spasms no injury can be sustained ; attention should be paid to his bladder and bowels, for catheterism is sometimes called for; and purgatives and enemata to clear out the intestines are beneficial, although violent purgation cannot be advised. Question of Amputation. — With respect to hcaJ treatment, much may some- times be done. In severe local injury when the nerves of the part are probably involved amputation ought certainly to be performed, for a sufficient number of cases have been recorded in which success has followed the practice. In 1845, Mr. Key amputated a leg on account of tetanus which had appeared six days after an unreduced dislocation of the astragalus; the symptoms disappeared at once after the operation. On dissecting the foot the posterior tibial nerve was found to have been put violently on the stretch by the pro- jecting astragalus. In some cases soothing applications, such as opium, may be applied to the wound, and in all perfect cleanliness should be enforced. One other means of cure remains to be noticed which has reference to the mode of death in this disease. It has been shown that in the larger proportion of cases — in all the acute — death is caused by suffocation from spasm of the laryngeal muscles. It is also fairly recognized that this disease runs its course, and that the most our science can accomplish is to maintain life and ward off death. To this end the operation of trache- otomy seems to be of value, for with a tube in the trachea death by laryngeal spasm can- not take place, and a better prospect of recovery is consequently given. I have employed this practice in one acute case, in which the Calabar bean was like- wise given, and the patient sank from exhaustion, free from spasm ; and there seems good reason to believe that if I had performed the operation in the case I recorded in the early part of this chapter life would have been saved. This matter, however, requires grave consideration, and the practice is not to be rashly followed. Morgan, On Tetanus, 1833. — Curling, On Tetanus. — Poland, Guy's Hospital Reports, 1857. — Dr. Ogle, Brit, and For. Med. Review, 1868.— Dr. Dickson, Med. C'hir. Trans., vo\. vii. — Dr. L. Clarke, ibid., vol. xlviii. — Dr. Dickin.son, ibid., vol. 11. — Demme, Schmidt's jahrb., vol. 112. — TiiAMHAYN, O., (■6i(/.— Fea/'-£ooi-, Sydenham Society, 1862-64, etc.— " Puerperal Tetanns," Dublin Quart. Jour., 1865; Med. Times and Gaz., 1865. — Billroth, Pathol. Chirurg., 1868. DELIRIUM TREMENS. It often falls to the surgeon to treat cases of pure delirium tremens uncomplicated with any surgical malady, and it is well, therefore, to refer to this subject by itself. There are other cases, perhaps, more aptly described by the term " traumatic delirium" in which the nervous symptoms are developed as a consequence of an injury received. In both classes the symptoms are essentially the same and the treatment required is sim- ilar; still, it is right to bear in mind the difference in causation, as in the one we have to deal with a nervous disease in an intemperate person, and in the other with the same symptoms as an incident in a surgical case. In simple delirium tremens, to use the familiar term, we have to deal with the case of a person who has indulged for an uncer- tain time in injurious doses of alcoholic liquors. It may be that a young man after a prolonged debauch has an attack of the " horrors," but the symptoms more frequently occur in those who have for a long period accustomed themselves to the excessive use of beer or spirits, even without amounting to drunkenness, and who at length are sub- jected to some shock or depressing influence. Inasmuch as the habits which have been mentioned as superinducing this disease are opposed to the simplest laws of health, it follows that they cannot be indulged in with impunity for long, and consequently we find DELIRH'M rilKMESS. 223 the subjocts of if, as a rule, ol" t'rclilc |M)\vcrs of rcsistiiiicc ami ol'tcti with disoascti vIh- cera. Sucli persons arc hatl siihjcfts I'nr any aihnfrit, and it often lia|t|M'iis that when a person ol'this sort breaks his h'U' or meets with some injury rc(|niriii^' sur;_'ical treatnn-nt he becomes the subject of (U'lirium tremens. Other causes are oceasionally at work, such as starvation, mental an.viety. ami the overuse of tobacco or opium. 'Pile disease is at times ushered in by certain premonitory symptoms, as patients who have onci' been the subject of an attack are sometimes conscious of tin; approach of another. .\ brewer who liad been treated for this affection at («uy's some years af,'o, when lie felt warninj:;s of its advance on several occasions applied for admission, and as a result the attack was warded off. Depression of mind and de))re.ssioii of body are the chief premonitory .symptoms, with restlessness and agitation, foLLM'si-:. 225 ert'd with ;i cold claniiiiy swi'at. lie may lircallic aliintst iiiipcrccptildy, fctrlily, or with sijj;hs and ;;as|>s. His imstrils will innliahly he dilaliMl, his eyes ilull, his vision imperfect, and eonseioiisncss may In- lost in vny variaMe de<;rees ; the patient may j)ossil»ly he roused, yet, as a riUe. he n-ijuires roiisin<; to prove the existence of consciousness. At otiu'r times the intellect remains quite clear. 'riu'se are, briefly, the sii^ns of c(dlapse or shock the result of injury. They are to be found in variable decrees after most accidents, and are by no means usually fatal urdes.s the injury it.self is fatal. Of course, if the shock from the injury is very jrreat, the heart may cease to l»eat and the luiijis to breathe, collapse passing more or li!ss slowly into death ; but m()rt^ usually, after a variable period, the heart's action frradually improves, the respiratory act becomes more rcLiular, and jicrfect color returns to the bloodless lip.s and skin, w.irmth rcap]icars on the surface of the body, and consciousness becomes more manifest. Tlu'se syni|)toms indicate what is known as reaetimi ; and when they are excessive, febrili' .symptoms nuiy appear. It sliould be noted that voniitin wn iivsrhn/cAL o/: Mnii('Ki:i> disease. Til (Iclav nt' a I'rw (la\> (ir Imiirs is iiiiiiii|iiiitaiit . all ii|icrat ivt; iiitfriVrciicc; should be post- |i(iii(-il. ill severe e(iiii|MMiii(l IVael iirc-:s. ^iiiislmt (ir utlieiuise, liemurrliaj;<* is almost suro to occur as soon as reaction apitears. ami the ^hoclv of the removal ot" a limit is not so much to he (Ircudcil as tin* loss ol" hlood. • Wounds of symptoms and to doubt his diagnosis until he has proved its truth. To the sn/t/rrfive symptoms, or those complained of by the jtatient, these remarks are very applicable ; but to the o/>Jec/ire, or those palpable to the observer, they are so to a degree. The subjective symptoms are always exaggerated, the objective inconsistent, the former being too bad for truth, the latter inconsistent with experience. For example, the rigor of an ague may be simulated, while the hot and the sweating stage is impossible. Epileptic convulsions, catalepsy, or madness may undoubtedly be imitated, but in all these there will be, when present, some exaggeration or incon.sistency not found in the real disease. Nerve pains may be felt, but they will nor follow any anatomical nerve distribution. Paralysis can also be readily simulated, but it will prob- ably be too complete ; it will on testing, more particularly when done unexpectedly, be associated with a greater degree of sensibility in the skin than is usuallj- present. When of long standing, it will not be attended with the usual wasting. Vomiting, coughing, or spitting of blood can be artificially produced, though under these circumstances the severity of the symptom will probably contrast strangely with the mildness of any others with which it nuiy be attended. In fact, in feigned diseases, on a careful investigation into the history of the case, the succession of symptoms, their progress, intensity, and duration, some element will be brought out which is irreconcilable with truth, some suspicion that deception is at 228 FEIGNED AND HYSTERICAL OR MIMICKED DISEASE. work will be excited, which, if worked out, must unmask the imposture and prevent error. The subjects of hysterical disease or of nervous mimicry are mostly what are called nervous and emotional. They have commonly " a very unusual mental character : in the majority there is something notably good or bad, higher or lower, than the average — something outstanding or sunken." In this affection " every part of the body may become under provocation the seat of an apparent disease that in reality does not exist ; it may, and often does, assume all the attributes of reality with an exactness of imitation which nothing short of careful and accurate diagnosis can distinguish from the real dis- ease." In joint and spinal disease the truth of this is most frequently seen, Brodie having stated " that among the higher classes of society at least four-fifths of the female patients who are commonly supposed to labor under diseases of the joints labor under hysteria." Di.\GNOsis. — How, then, it may well be asked, is the hysterical affection to be made out from the real ? How is the surgeon to avoid falling into the error of treating some functional derangement as organic disease ? In a general sense, it may with truth be laid down that in hysterical affection of a part local pain and sensitiveness on manipulation are always great and bear no relation to the amount of changes visible or to be detected in the part. The slightest touch excites pain, which probably a bold one fails to do ; the pain, too, rarely, if ever, follows the anatomical course of any nerve or nerves, and the onset of the symptoms is generally more sudden and severe than that usually ushering in organic affections. Febrile dis- turbance or increase of temperature, moreover, rarely complicates the case, however severe the local symptoms may be, and the nervous "disturbance very rarely takes the form in which morbid nervous influence produces, not mimic, but real, organic changes." In fact, all the subjective symptoms are much more severe than the objective, the latter being either very slightly marked or non-existing. For example, a girl is suddenly seized with severe and lasting pain in the hip, knee, or other joint, aggravated by movement or the slightest touch, and yet no visible alteration in its outline or structure can be detected, even after the lapse of many months. Another is as suddenly affected with spinal affec- tion, as indicated by local pain in the back, inability to stand, etc., without any local evidence of organic disease. A third suddenly finds herself unable to flex or extend a limb, and the slightest force excites severe muscular spasm and pain. A fourth is attacked without a cause with some muscular spasm, possibly involving a finger or fingers — a spasm that resists all attempts at extension. A fifth suddenly loses sensation or the power of motion in some part of a limb, quite irrespective of nerve supply. In these cases, again, however severe the pain may be during the day, it is rarely felt at night. Such patients, as a rule, sleep well and quietly. During sleep, also, it often happens that joints which are immovable by day are found to be more flexed or more extended. Patients with supposed diseased spine are found on their sides coiled up in a natural attitude. As an aid to diagnosis, the value of some anaesthetic cannot be too highly praised, as with a patient under its influence rigid parts rapidly yield and rigidity of muscle returns only with consciousness ; parts supposed to be paralyzed often move, and suspected joint disease disappears by a close examination where previously doubt existed. Hysterical disease is more commonly met with in female than in male subjects, in the single than in the married, in those whose nei'vous systems have been unstrung from some mental or physical trial, or where the emotional centres are inadequately balanced by the higher controlling ganglia. It is characterized by the suddenness of its attack and the severity of all its subjective symptoms, neither the clinical history of the case nor the objective symptoms present being consistent with those usually met with in organic disease ; the exaggeration of certain symptoms and the absence of others, coupled with the anomalies of its nature, mark the hysterical affection over the organic, and are sufiicient to excite a doubt as to the true nature of the affection. For valuable information on this subject, the reader may be referred to the lectures of Brodie, Skey, and Paget, Russell Beynolds's essay on hysteria, and Anstie's lectures in Lancet. .V/7.V.I ItlllHA. 229 CHAPTER VIT. INJURIES AND DISKASKS Ol' TIIK Sl'TNi:, KTC. Spina Bifida. A SPINA i{iK(i>A is essentially a con<:ciiital licniia ofthe membranes of the cord through an oponin;^: in the spine, due to deficiency, IVoiu arrest of development, of the neural arches of some td" the hones formin'^t3fe ^ Cured Spina Bifida. (Taken from a man set. 26.) SACRAL AM) cnrCYGKAL TUMORS. 231 any jirt'ssurt' was ii|)])lii>il lu tin- tiiinnr. ev«Mi from tlie woi^'ht of the Ixxly when i*iaced ill the supiiH' |)(tsitiiiii. The tiiiiinr was lar;.'e ainl si'iui-traiisparetit. 1 punctured it i)lili([uelv with a tiarninir-iK'iMlh' at intervals of two or three days, four or six tinn-s. and applied a compress of lint liy means of strajipini: over the tumor. After this the fluid was not airain seereted. the eonvulsions eeased. and the ease pit well." At the i»resent time a hard pucken-d tumor alone «'xi>ts to indicate tiie atfeetion. \ model of the ea.se may now he found in (Juy's .^Iu.se^lm. Dr. James .^Il(rton of (llasirow has advocateil the injection at intervals of .seven or ten days of half a drachm of a solution made hy di.^solving ten irrains of iodine and thirty i jrrains of iodide of potassium in an ounce of trlyeerine. The injection should he thrown into the sac after tl»e withdrawal of some small ])ortion of the spinal fluid. Dr. Morton reports ( (iliKi/inr Mol. Jouni.. May. ISSl) that out of twenty-nine cases operated upon there were hut si.x failures. Tiiis success is enei.urai^injr. The operation, however, has its daiiLTers. In a ease of my own. after the .second tapjiinir. there was .so much draining of the fluid from the cord that the child died from exhaustion. After death there were no signs of inflammation of the memhranes. Tn no ease where the ha.se or neck of the tumor is lar<;e. injr in others in which it is evident the cord is implicated or larire nerve trunks are involved, .should this or any other operation he |)erformed. In pedunculated tumors it may be attemjited. With respect to the pxrisiuu of the tumor, a succes.sful case has been recorded in the Filth. Soc. TniD.s., vol. xiv., in which Dr. Wilson of Clay Cross removed the tumor five days after the closure of its neck by means of a clamp: and when excision is entertained, this plan is probably the soundest. It should, however, only be thought of when the nock of the tumor is narrow and there is no paralysis of the lower limbs or incontinence of feces or urine. In all broad-based tumors associated with paralysis operative measures are out of the question. Exceptional cases of recovery are on record after every form of practice, but. on the whole, the results of treatment are not very encouraging. Sacral and Coccygeal Tumors. Congenital tumors are by no means unfrequent in the neighborhood of the coccyx or sacrum. They are sometimes composed of cysts, occasionally of fat or fibre tissue, and also of fuetal remains. They are generally central. Many of these have doubtless been described as false spina bifida, and in rare examples there is reason to believe they are cured cases of spina bifida, the sac of the hernia having been occluded at its neck by the natural contraction of the surrounding parts. I have seen one such ca.se in an adult where the tumor was successfully excised. Mr. Pollock has recorded in the eighth vol- ume of the J\i'/t. J/-a//.s. an example of a congenital fatty tumor which he successfully removed from the central lumbar i-egion of a child jet. 7, and Mr. Athol Johnson, in the same volume, a rare ca.se of fatty tumor clearh' developed in the spinal canal itself. I have had occasion to remove a large congenital sebaceous cy.st placed between the anus and coccyx from a child xt. 10, and from another child a tumor containing ftetal remains, situated between the sacrum and the bowel. I may further refer to a third interesting case of cystic tumor of the sacrum, possibly spina bifida, in which the cyst burst and complete recovery followed. The following are the brief notes of the two latter cases. Marie B , ret. seven weeks, was brought to me in 1SG8 with a congenital tumor the size of a large orange projecting from between the bowel and coccyx and apparently passing up in front of the bone fFig. JsO). It had been growing rapidly .since birth and was pressing upon the bowel, though the child in all other resjiects was healthy. I excised the growth and found that microscopically it was made up of fat. fibro-cellular tissue, mucous membrane, cartilage, and bone elements. Recovery ensued, and the child has kept well. A male child two days old was brought to me on July 30, 18G8, with a large cystic tumor covering in the lower half of the sacrum and occupying the perina?uni. It was the size of a cocoanut and transparent as a spina bifida, yet in all other respects the child was wellformed. The next day it burst and many ounces of a blood-stained fluid escaped. The .sac collapsed, but no evil result followed this bursting of the cyst. I watched the child for many months, and on November 80. 1871. the tumor had contracted up to an irreizular indurated mass of integument. The child was very healthy. Treat.ment. — The only effective treatment is the excision of the growth, which 232 INJURIES OF THE SPINE, CONCUSSION, ETC. should be done unless symptoms exist, such as extensive or dangerous connections of the tumor, to contraindicate the practice. Special care should be taken to ascertain that no communication exists between the tu- FiG. 89. Fig. 90. mor and the spinal canal. 1^ ^ ^j Fig, 00 represents a most interesting case, the particulars of which were kindly forwarded to me by Dr. Mercer Adams of Boston, Lincolnshire, who operated. The tumor was successfully removed from a female cliild get. 10, and meas- ured 22 inches in circumference ; it wa.s composed of cysts, and the largest, which was central, was lined with true skin cov- ered with long silky hair.s. This cyst con- tained thick putty-like material. From one of its walls grew an improperly de- veloped foetal leg and foot having three Congenital Coccygeal Tumors. toes with perfect nails. There were also several curiously shaped foetal bones scat- tered through the tumor — one like two coalesced ribs, and another a parietal bone. The tumor had deep pelvic attachments, and had to be dissected from the rectum. The lower part of the sacrum merged on the tumor. Hewett, Med. Gnz., vol. xxxiv. — Behrend, Jourii. f. Kinderkrankheilen, vol. xxxi. — Xelaton, Path. Chir., vol. ii. — Holmes, Snrrjical Treatment of Children's Disease.", 1869. INJURIES OF THE SPINE, CONCUSSION, ETC. The spine is a flexible tubular column composed of ring bones alternating with a dense elastic intervertebral substance. These bones articulate by means of joints, and are bound together by strong yet elastic ligaments. From the upper orifice of the tube the spinal cord with its membranes is suspended in a chamber filled with cerebro-spinal fluid and surrounded by large venous plexuses. The coi'd terminates opposite the second lumbar vertebra, but the membranes are continued down to the second piece of the sacrum. It is suspended in position by the nerve trunks that pass with the processes of dura mater that accompany them outward between the bones. A local injury to the spine, such as a forcible bend forward, may sprain or lace- rate the ligaments that hold the bones in position. A still more forcible bend may crush the bodies of the vertebrae that form the anterior portion of each ring. If the force be still continued upon the broken bones, displacement may take place, when the delicate cord itself will either be slightly pinched between the displaced bones and con- tused or completely crushed or divided. In the cervical and lumbar regions — not in the dorsal — the bones may be dislocated, the amount of injury to the cord depending entirely upon the amount of displacement that has taken place. When such displace- ment is very slight, the cord may be uninjured. Sprains of the back may also at a later period be followed by disease both of the joints and bones of the spine. A diffused injury to the spine, such as that caused by a fall from a height upon the back or by a heavy falling body, may produce some fracture or dislocation of the bones of the spine, but it must to a certainty likewise cause a severe shaking, as from a railway accident, or a concussion of the spinal cord itself, as manifested by a more or less complete suspension of all the functions of the cord, either for a short period or for life. This concussion or shaking of the spine may be accompanied by hemorrhage into or upon the cord, giving rise to compression, or may be followed by acute or chronic intraspinal inflanmiation. terminating in paralysis and death. In both local and d'lffnaed injuiiea of tlie .yjuie the (jrarity of the cat^e dependn chlcfli/ upon the amount of injury the cord hai< sKsfa^'ned ; a severe local injury to the osseous part of the spine can be completely repaired without danger to life, whilst any injury to the cord and its membranes is fraught with danger, either directly by suddenly arresting the functions of the parts to which the injured nerves are distributed, or indirectly by setting up chronic inflammatory changes in the cord. Concussion of Spine. — When the functions of the cord have been directly sus- pended by any local or diffused injury to the spine, the patient is said to have suff"ered from concussion of the spine. Should the symptoms be complete and persistent, there is i\.iii:ii:s or Tin-: sr/XK coscussios, etc 233 fjdod rcasdii tu liclicvc tliat tlic ciinl l)a> Ittcii (•ni>Iic(l Ky .'»<>iin' (lis|»lacciii('iit of a f'rac- turril or dislocated Imiic. Should soiiu' interval of tiiiu- have taken plaee hctweeri the roeeipt of the aeeideiit and the )»aralysis. there is a lair suspicion that the paralysis is th<' result of some heinorrhatrc into or around the cord. Should the paralytic symptoms have i'ollowi'd the accident after a few days and he attende(l with constitutional disturh- aiice (U" spasm of the muscles of the limhs, the cause of the paralysis was prohahly some inflammation of the cord and its memhranes ; and should the paralysis liuve been of a slow and |»roirressive nature, the jirohahilities are that it is the consequence of some chronic softening of the cord, because all those different results have followed local and difiused injuries to the spine. Moreover, it is the knowledge that they may take place which renders any spinal injury a matter of importance, both as regards the immediate effects of the injury and its secondary eonsef|uences. I am bound, however, to add that Mr. I'age in his recent interesting book on spinal injuries "doubts whether any jiassing paralysis following a severe l»low on the vertebral column is not m rcco^nizi,' \\ut very oarliost iiidicution of iiitlaiimiatiiiy artimi, in unli-r that it may \n' arn'strd ; f'ljr. as it lias been shown tliat tin.' cliifi' aim in tin* trcalnu-nt ot" all tlu'si- injuries is to prevcMit the occurrL-not' of inflam- mation, sti the si'cund is t(i try and arrest its inoj^ress as soon as it has a|i|ieaied. When it has liecome thoronirhly estahlished, neither medical nor siir<;ieal art has much power in eheekini; its projrress or in correetini:' its etteets, as the delicate structure of the spinal cord ap])ears to ho incapahle of underjroin;; material repair when softcMied hy disease or crushed Itv accident. The cord structure, whi-n once destrtjyed, is replaced hy means of a fihrous suhslance. I'aralysis or loss of function, under these circumstances, is jM-rma- neiit. [n any case, therefore, of spinal injury, when the symptoms are persistent or tend to hevome worst', when after their partial or complete disajjpearance for three or four or more days they recur or appear in s(>me altered form, when local pain is increased and inovemont of the hack is more difficult or distressing, when pain follows tlie course of the nerve trunks that emanate from the injured spinal centre and muscular spasm or paralysis is ])resent, and, moreover, when constitutional disturbance or general fehrility is present. — whtu any or all of these symj)toms, few or many, are found to follow a spinal injury after the first effects of the accident have passed away, the diagnosis of secondary inflammation of the cord may fairly be made and action taken upon it. In ii' ni'iiil r(iiicKssit)iis of the ^piuid cord, more particularl}' from railway accidents, when, owing to some general shaking of the body, the spinal, cerebral, sympathetic, and circulatory systems are all more or less involved, there is an undoubted disposition for a chronic inflammatory change of a most insidious and creeping kind to supervene. In some eases, however, the change is rapid, as in the case of a matj get. 46 who was admit- ted into Cruys with complete paralysis and loss of sensation of his body below the first rib, the result of a fall down twelve stairs the day previously. The day following his admission some slight feeling returned in his body, and a few days later he could move his legs. The paralysis, however, never left him, and he died on the thirty-eighth day, of lung di.sease. After death the spine was found uninjured, but the spinal cord opposite the sixth dorsal vertebra was soft and diffluent and contained granules. There was no trace of eftused blood. It is now well known that the primary sjiinal symptoms are often so mixed up with the general as to be masked, and, beyond a general but temporary loss of power and con- sciousness, there is often nothing special by which spinal mischief is manifested. On recovering from the shock of the accident and the mental disturbance the sufferer often feels no definite injury, no special local symptoms, and it may be that it is not till after some time has elapsed — the duration of which is also uncertain — that any special symp- toms make their appearance. It will then probably be found that the patient has never been himself since the acci- dent ; he has been unable to work, mentally or physically, with the same force or energy that he did previously, is irritable in his manner, and perhaps feeble in his powers. Sleep- lessness, too, has been more complete or common than it was before, and headache with general malaise now often exists. Premonitory Symptoms. — Some slight unsteadiness of gait is often the first observed symjitoni. a feeling of heaviness in the limbs, some abnormal sensation, such as that of pins or needles, numbness along the course of a nerve, cramps, perhaps retention of urine, or some evidence, in fact, of want of control or power over the muscular appa- ratus, and more marked generally in the lower extremities than in the upper. The cen- tres of sensation may. at the same time, show indications of disturbance, either by a .state of lessened sensibility or perhaps by a hypenvsthetic condition. From sj'mptoms such as the.se the attention of the surgeon is probably arrested. On testing the muscular apparatus thoroughly it will probably be found that the patient will be unable to stand steadily on one leg, or, what is a better test, if he place his heels together, he will totter on making the attempt to raise his body on his toes. When asked to stoop to pick up anything from the ground, he will probably bend his knees rather than his back and walk with a rigid spine. On giving him a small object, such as a pin. he will take it clumsily and with tremor — will fumble at most things with his hands and stumble at anything that is in his way. On examining the spine some tenderness may be manifested on firm pressure, but probably only in certain places. Percussion on the bones is hardly a fair test ; when employed, it should be indirect, through the fingers. Pressure applied to the spine causes at times severe pain, as does any movement; it is the latter condition which induces the rigidity of the spine in walking, before alluded to. 236 INTRASPINAL INFLAMMATION, ETC. The brain and organs of special sense may likewise be aifected, either by over- or under-sensibility. Vixion may be imperfect either in one or both eyes ; luuriiui may he over-sensitive or defective ; taste and touch may be perverted or lost and Rmdl at times destroyed or morbid. In fact, the whole nervous system, cerebral and spinal, may be disturbed and its functions more or less damaged. The course which such cases run is very uncertain, and the prognosis is therefore difficult. When the motor-power has been lost from spinal mischief, the best test is gal- vanism. A healthy muscle supplied from a healthy nerve centre will always contract on the application of the galvanic current. When the nerve centre is so diseased as to cause paralysis, the galvanic current produces no movement — no contraction. This test is beyond the patient's control and cannot be resisted; it is consequently valuable. Caution in Interpreting Symptoms. — In interpreting these symptoms, more particularly in a railway case, or in any where the question of damages is involved, it is most important for the surgeon to separate the symptoms of which the patient complains, the suhjWfive. from those he can himself perceive, the objective. Let him doubt and cross- examine in every way upon each of the former to test their accuracy. He may rely, however, upon the latter, and any positive opinion ought to be based upon these alone. There always hangs a suspicion over the former because self-interest points to making the worst of them. All the symptoms, taken as a whole, undoubtedly indicate a chronic or subacute inflammatory change of nerve tissue, an inflammation of the membranes or of the cord. When they appear as a consequence of a general concussion of the spine, the cord is probably the seat of mischief, its delicate structure being more liable to injury than the tougher membranes, and, consequently, to secondary changes. When they follow some local injury, such as a twist, blow, or forcible bending of the back with laceration of liga- nients, the disease in the cord probably is secondary to disease in the membranes, the inflammation of the latter being due to the extension of inflammatory action from the injured part inward. '• Inflammation of the membranes of the cord, as of the brain, is a disease not idiopathic, but proceeding from some cause without." But whenever this commences it is progressive, and in the end involves all the tissues in its destructive changes. Pathological Changes. — The pathological changes themselves are tolerably defi- nite. In the cord they put on the appearance of red softening in recent disease, and of white in chronic. The parts are .soft and pulpy, the microscope showing them to contain granule corpuscles and elements of the inflammatory process. The wlnte matter of the cord will appear at times sound, while the gray substance is soft. The disease may be local or more general. In concussion the latter is the more common condition. When it is in the cervical region, death is rapid ; when in the lower dorsal, life may be prolonged for some time. This fact is well illustrated in fracture and dislocation of the spine. Treatment. — In all cases of concussion of the spinal cord, simple or severe, absolute rest m the horizontal posture is most essential, and in mild cases this is probably the only treatment called for ; the symptoms, by the observance of this rule, gradually disappear, and the health is restored. The prone position in more severe cases is generally to be preferred to the supine, but the best guide in this matter is the ease which the patient experiences. The surgeon, however, must enforce quiet for many days after the disap- pearance of all symptoms, even in the mildest cases, on account of the primary danger of intraspinal inflammation, and the period of rest to be enforced must be in proportion to the severity of the .symptoms. In cases of railway concussion this practice is of primary importance, and I am disposed to attribute the frequent occurrence of obscure railway spinal cases to the non-observance of this rule. It is true that in the majority of cases there are no definite indications of spinal injury after the accident, though the nature of the accident itself is a sufficient guide to the case. A general shaking of the body means a general concussion of the spinal cord with every other part, and the nerve centres, by reason of their structure, are most liable to injury. It would be well, therefore, to keep all patients who have been the subjects of such injuries quiet and in repose for several weeks after the accident. By doing this much mischief would often be avoided. After concussion, when severe local pain is experienced, relief is often given by the application of a dry cupping-glass on either side of the painful part, and the operation may be repeated. In exceptional cases the local extraction of blood may be found of benefit. The application of cold is a powerful remedy for good when there is much eflFu- sion of blood or pain in the part, and when the symptoms of reaction are too marked. FiiAcrrinis am> hisi.ocArioys or riir. sriM-:. 2:i7 The ilift >liuiilil III- iiiitrilii)iis, Imt iiiist iiiuilat iri<;, and iiijtliiiiliysi insLor.vnnsss or Tin: sn.\i:. 239 Till' fact of tluTf btMn<; im (lis|ilac«'iiu'iit of tlic luokcn Itoncs and no injury to tho cord pn-vciitoil a correct diagnosis hcint: made. I have seen also u case of fracture of the spinous processes rtf the last dorsal an|iiri(' arc f^oncrally fatal witliiii tlin-i- days. Iiijiirirs to the dorsal, when not proviii;^ fatal witliiii tin- tliinl wtnk. may l)o surviviMl fur iiKtiiths, and even years, the duration ol" lil"e JMinir greatly determined !)y the warilin^' off of the secondary eoni|>lications wiiieh so frcijiiently arise. Tkk.vT.MKNT. — The iliairnosis of a fracture or dislocation of the s](ine having' lieen made, the most essential point to attend to is to keep the part aljsoliitely unmoved. The patient should he examined with the j^reatest care and moved with every pos.sihie ])recaution, as any motion may add to the injury the cord has sustained and increase the danger to the patient. Ivxtension of the spine may be employed when much deformity exists, and j)articnlarly when severe pain ari.ses fnnn nerve j)ressure, but extreme caution is reijuired in followiiiL; this practice ; it is not to be employed in every instance, but onlv when local svmptoius seem to suggest the probabilities of a reduction of the dislo- cated or disphiced bone or the relief of pain. I have known cases in which a successful reduction of displaced bone has been effected by extensitjii, and seen others in which marked relief was afforded ])y this course. Practised with discretion, extension of tht spine is doul)tless a valuable means of treatment. A good example of this occurred in the ])ractice of my colleague, Mr. Davies-Colley, on March 14, ISS!^, when a n)an ;et. 50 was brought into (Juys after having been double, ISllS). Mr. Sliaw, in /Iii/ims's Siiiyrri/, <.Mves a case where the hh'edin<: lasted lor lour days, eeased lor two, and then rea|>peared in all its severity. Alh-r tin; lapse of two more days it aj^ain eeased for twenty-four hours, reappearin*; lor a third time severely, then eeasinir. and a j/ood recovery folhtwed. When tin- kidneys are dis(!used. and when ealeuli :i1mp f\i^t in tlnni. tlii- «-ynipl>im i- luorc lik<'ly to appear after injury. Hemorrhage into Spinal Canal. — ileniorrha^t' may take plaee into the spinal canal as the result of a sprain or laceration of the li;^aments, the hlood prohahly ll(»wiiif^ from a laceration of some of the larjre veins that surround the cord or from a spinal artery. Sir !'. Ihwett has related a ease of sudden death from a fall on the head, recorded hv Mr. heville in 1S4;) ( Mnu. ilr ht .Sue. tic C/iinny. io another ca.se somewhat similar in symptoms, though not in result, where the patient recovered after two year.s Tre.vt.mf.nt. — In all the.se cases of sprain, slight or severe, re.st is es.sential, the suf- ferer being allowed to assume the position in which the greatest ease can be rtbtained. The application of cold by an ice-bag or a metallic coil is al.so of great .service where much swelling or jiain exists. In other ca.ses a warm poppy fomentation gives relief, or a mixture of belladonna and opium rubbed down with glycerine and applied on lint. When spinal symptoms are present, the greatest caution is needed, and the case ought to be treated as one of concussion of the cord. In bad cases it is wise to fix the spinal column in a surgical ca.sing, with the object of guarding against secondary inflammatory changes both of the spine and cord ; and this absolute immobility of the spine should be maintained for months. Rest in the horizontal position for seven or eight weeks is essential in less .severe cases, and even in the mildest forms exercise must be sanctioned with caution. When hicmaturia occurs, it requires no special treatment unless severe, when gallic acid in gr. v or gr. x doses two or three times a day may be given, or, what is better, the subcutaneous injection of ergotin in doses of two to five grains dissolved in five or ten minims of distilled water employed. CURVATURE OF THE SPINE. There are two forms of curvature of the spine — iateral and angnhir. The lateral is due to a relaxation of the ligaments and muscles of the spine, which in a healthy subject maintain the bony column in its normal position. The angular is secondary to organic disease of one or more of the bodies of the vertebrae or of the intervertebral substances, and is generally known as " Pott's curvature." Lateral Curvature of the Spine. This is by far the more common form of spinal curvature. It is generally found in girls between ten and twenty years of age, sometimes in young children, and is fre- quently, though not always, associated with want of power. It is more common in the middle and higher classes of society, where sedentary occujiations and luxurious ener- vating habits too often exist, than in young women who make full use of all their mu.s- cles and lead an active life. It is encouraged by any one-sided posture of the body, whether this be the result of some fault}- habit or of occupation, of overuse of one limb, or of any disease or deformity of a lower extremity which occasions shortening of the limb. In its early stage it is seldom discovered, and attention is, as a rule, drawn to the disease by some " growing out ' of one shoulder, generally the right, .some distortion of the chest, or some tilting upward of a hip. The.se deformities are frequently fir.st noticed by dancing- or drill-masters. When a curve has taken place in the upper dorsal region of the spine to the right side, a compensatory curve is certain to be found in the lumbar to the left. In investigating a case it is important to bear this fact in mind, as the con- 244 LATERAL CURVATURE OF THE SPINE. Fig. 94. Fig. 95. Anterior view. Posterior view. Lateral Curvature of the Spine. (Guy's Hosp. Mus., No. \m&». Taken from Emma J , ret. 14.) secutive or compensatory curve, unless of long standing, will soon be remedied when the original one has been cured. Associated with the lateral curvatures there nece.ssarily must be some rotation of the spine. The amount of this is very variable and depends upon the extent of the curva- ture ; it is doubtless due to the forcible bending of the bones downward with the ribs, these latter helping to rotate the vertebrae upon their axes. The bones may be so twisted that their transverse processes project backward, carrying the ribs with them, the anterior sur- ftices of the bodies of the vertebrae looking toward the convexity of the curve and the spinous processes later- ally toward the concavity. The thorax is thus much distorted, the side corre- sponding to the curve being expanded and the oppo- site one greatly contracted. This is well seen in the annexed drawings, Fig. 95 taken from a living patient and Fig. 94 from a preparation. In some otherwise healthy and in rachitic subjects there exists an exaggeration of the natural curves of the back. When it is in the upper dorsal region and backward, it is called '■^ q/pliosis;'' when in the lumbar and forward, "lordosis." This latter curve is very frequently found as an accompaniment and result of hip disease when the thigh is flexed or adducted, and it is always present in congenital displacement backward of the head of the femur. The DIAGNOSIS is not very difl&cult when the deformity is well developed, the double curve giving the spine a sigmoid form, which is typical. In less severe cases this curve can readily be removed by extension of the body, either by lifting the patient from the ground by a hand in each axilla or by — what is better — the vertical suspension of the patient by his hands from a bar or a pulley. In the more severe forms, such as that shown in the above figures, the deformity is permanent ; the ribs are thrown out in an extreme degTce, pushing the scapula outward and upward, and the lumbar curve is in the opposite direction to the dorsal. The whole thorax, abdomen, and pelvis are alterec^ in shape and position by the deformity. Treatment. — In treating these cases it is necessary in the first place to determine the cause of the deformity. Should there be any structural disease, such as a growth or carious. bone, this will require attention, and the alteration in the spine becomes thereb}' a secondary matter. But in the great majority of cases of lateral curvature the spinal affection is the result of impaired health, and constitutional remedies are demanded. The treatment must be directed to an improvement of the general health, and tonics should be administered, such as iron, quinine, and cod-liver oil. Good air and good food are also essential. In certain cases local treatment is of great value. The feeble muscles and weakened ligaments should have rest, though they are to be kept in health by moderate exercise ; they are never, however, to be fatigued. If fatigue be experienced from walking one hour, such exercise must be curtailed to a shorter period. If backache be produced by exertion, less must be taken. Exercise is to be allowed, but not to the extent of producing fatigue. Sitting and standing ought not to be sanctioned. The patient should recline at stated intervals in any position that gives the greatest ease. When the deformity is definite and the dorsal curve is to the right side, as is nearly always the case, the patient should rest upon that side with a pillow beneath the right arm, the weight of the body in that position acting as an extending force upon the curved spine, and thereby tending to reduce the curve. By resorting to this practice two or three times a day for a definite period, depending upon the nature and severity of the alFection, much good may be obtained and very severe curvatures remedied. Cold sponge sr/XAL i>fsj:As/:. 245 or slmwtr ImiIis. if tlicy fan lie Iportic, arc always iMinficial ; sd also is a iiKnIi-ratcl v firm hi'd, a sjiriiiLC luattri'ss lii-iii^ Ixtti-r than a Icatlicr linl. (itMitlc falistlicni<- exorcises are valiialilc ailjuncts to treatment when practised with (liscreti(»n, and jtariicularlv the volun- tary vertical extension of the jiatient's iKtdy }»y manual suspension IVom a liar or pulley; yet it should he n-meniliered that a weak sjiini! is heinj.' dealt with, and ativthin^' like vioh-nee may he very detrimental. Should the curvature have heen cncouraLreil hy any faulty hahit. such as slaridiii;: on one \vve the jreneral condition of the body ; 2. To give rest to the strained atul weakened muscles and liframents ; ;>. To streuirthen the muscles that .support the spine by exerci.se carefully regulated, .so as to prevent fatigue ; 4. To restore the spine to its normal direction by posture, muscuhir extension, aiul l)y pressure applied in the horizontal position. Mechanical contrivances have l»een much vaunted and are often employed. I confess, however, to having little faith in their value as cnrtitirc iKjciita. They tend to cause atrophy of the muscles tliat support the back instead of strengthening them, and thus to make the deformity permanent. In bad and exceptional cases they may. how- ever, be employed when the treatment sketched out cannot be borne or is inapplicable. The best supjtort is that of Sayres or one of the felt jackets. When the deformity is irremediable and sujiport essential to allow the patient to move about, an instrument is of great value. It is probable that the deformity in its early stage chiefly arises from a compres.sed condition of the intervertebral substance, it being well known that this material is capa- ble of being compressed one-fourth of its thickness. Hence a person by maintaining the erect posture during the day will be an inch shorter at night than in the morning. Any lateral curvature of the spine, however ju-oduced, unless remedied, will increase and be complicated with rotation. When unequal vertical compression is, therefore, kept up, the deformity produced by it becomes permanent, and the growing bones necessarily assume shapes and positions corresponding to the deformiiy and tending to increase it. Organic Disease of the Spine and Angular Curvature. This disease of the spine is due to a destructive inflammatory change of the bodies of the vertebra and intervertebral sukstances. It begins usually in the latter structure, although the bone itself may be its primary seat. It is at times associated with tuber- cular deposit in the tissue, though Fio. 9( Fig. 97. there is no evidence to prove that it is always due to the presence of tubercle. The curvature, gener- ally known as " Pott's curvature," is directly due to the destruction of the bodies of the vertebne and the intervening intervertebral sub- .stance, the upper vertebra falling down toward the lower and join- ing with it. When the bodies of many of the vertebra* are involved, the deformity will be .severe ; a prepai-ation in Guy's Museum (lOOr)^. Fig. OG) shows the bodies of twelve vertebriv implicated, but a cure resulted. Paralysis Angular Curvature of the .Spine, the "'''*}' attend this aff"ection. though same as ih.it iiiustraieU in Fig. 9r.. it is rare to find the cord involved ('taken from a iiatient iet. :>5.) ^i/^'\ Angular Curvature of the Spine. in the disease, even when the most destructive changes have taken place in the bones. Great deformity, even to an acute bending of the cord, may exi.st without giving rise to nervous complication (Fig. 97). The paralysis, too, may be lasting, but more commonly is only temporary. Angu- lar curvature may occur at any period of life, but is more liable to appear during the growth and development of the spine, and consequently is more frequently found in child- hood. From a remarkable preparation in the Guy's Hosp. Mus. (1004*') it would seem 246 SPINAL DISEASE. that it may attack the foetus in iitero and be repaired, the bodies of three or four of the dorsal vertebra? in this case being clearly fused together from disease, thus giving rise to angular curvature. When a cure takes place, it is generally by anchylosis ; occasionally, however, the parts are held together simply by fibrous tissue. Tlie disease more commonly attacks the lower dorsal region of the spine than any other, although the cervical and lumbar regions are not seldom implicated. In rare cases it attacks two different regions of the spine. It may run through its whole course, even to a cure, without giving rise to any extei'nal suppuration ; more comnionlv, however, an abscess makes its appearance. Spinal Abscess. — Pus will sometimes find its way from the dorsal region beneath the fascia that covers in the psoas muscle under Poupart's ligament, and then appear as a swelling in the groin at its inner half (psoas abscess). The swelling may burrow down- ward and involve the whole thigh in one large abscess. When the disease is in the lum- bar region, pus may burrow between the dense layers of fasciae that bind in the quadratus lumborum muscle and appear in the front of the abdomen above Poupart's ligament, and in rare cases pass down the inguinal canal and appear in the groin, simulating an inguinal hernia, or in the loin (lumbar abscess). In other cases it will make its way under the fascia that covers in the iliacus muscle and appear beneath Poupart's ligament, but at its outer half. In other instances, again, the matter will find a passage downward into the pelvis, and either make its way through the sciatic notch into the gluteal region (t/fufeal abscess) or pass downward behind the trochanter major to the thigh. In still rarer cases the pus appears by the side of the rectum. When the cervical region is the seat of the disease, suppuration may appear in the pharynx as a pharijuge.al abscess^ or externally in the neck behind the sterno-cleido- mastoid muscle. The following case is a good example of this : A boy Jet. 3 was brought to me at Guy's in 1862 for some affection of his upper cer- vical vertebrae consequent on a fall down stairs vipon his head. x\n abscess formed two months after the accident behind the left sterno-cleido-mastoid muscle, from which place a piece of the lamina of a vertebra escaped six months afterward. He kept his bed for upward of a year, when he got up with a stiff neck. He was unable to nod or rotate the the head, clearly showing that the joints between the occipital bone and the first two vertebrjB had been diseased and become anchylosed. In 18(37 this boy again came under my notice. His head was quite fixed ; the cervical vertebrae seemed shorter than usual, but no irregularity existed. The annexed drawings (Figs. 98. 99, lOU), taken from Ellen T . set. 1-4, a patient of Mr. Poland's, illustrate a severe case of cervical disease with lateral deformity. In this Fig. 98. Fig. 99. Fig. 100. patient a good result was obtained by means of the apparatus depicted in Fig. 100, the cure resulting in anchylosis. Exfoliation of Bone. — From any of these abscesses bone may exfoliate, and it may be coughed up from the phar3-nx or discharged through the neck. I have seen a mass of bone the size of a nut come away from a lumbar abscess, and a piece of bone clearly spinal discharged from an abscess of the thigh, opening above the knee-joint. In a case brought under my notice by a valued dresser, Mr. Burgess, the anterior half of the atlas, with its articular facets, was expectorated, recovery ensuing, the man being well eight years subsequently ; and in Gruy's Hosp. Museum (prep. 1018'^) there is a prepa- ration of the odontoid process which a woman who had had a stiff neck for months coughed up, and from which complete recovery ensued. Mr. Keate so long ago as 1835 recorded si'f.wii. hrsi-:.\si':. 247 (^Mfil.. Gaz.) a case in wliicli the aiiti'iiur liull" of the atlas (•xf'uliate*!, ami Mr. CoHis in his honk on .SV/y/A/V/.s, uiid Mr. ('(ippiii^er of l>ul)liii, in the iJiihlin .lonni.. Dccfiiiher. 1S7U, have both jmlilished iiistaiiees in whieh the eorn'SpoiKling portion of hone exloliati-tl. In fact, from all these sni'mt/ . 4ih.'ifrsgis hone may i)e (liseliarired, ami, wliat is more, recov- p^^5^Js^. 7V«/i»n cry fdllow. Anchylosis without Suppuration.— Suppura- tion, liowevtM", does not always take plaee. A woman let. .'{0 came iinder my eare in lS,")lt f(»r a stiHtiess of her head nn^,"iv'^^ and recovery ensued, but with a stiff' neck. My colleague, ^i!^X''^^ on well and no evidence of undue pressure in anv j>art exists, the casin;; may be split up alon<: the frdot. its edj/es bound, eyelets Ki(i. 1(14. Fig. 104.— Description of S.ayre's Apparatus as improved by Golding Bird, by which tl>e drag on the amis and head can be varied by altering the relative length of cords I and o. The smaller the angle at g, the more the drag on the head, and i-ur rersa." A fross-bar suspended by running tackle to Sayre's tripod or to hook secured to cross-beam of a folding-door. b. Pulley acting upon central bar, to the end of which are suspended the iron rings c, attached to the head-piece, e. D. Pulleys connected with arm suspender, F. by hook g, and h, ring, worked by running cord :16 inches long, ■which can be lengthened at will and fastened by cleats, o. K. Head-piece made of 2-inch worsted webbing sewn into a circle '2'k inches for adult, 2:J inches for children, with ^0 chin-piece made of wash leather, and (fti two circular sliders of same wel>, fi inches round, attached to iron rings, c. The sliders, by being slid forward or backward, can be made to pull more or less against the chin or occiput. F. .Arm-pieces made of 2-inch cotton- web 1 yard round, capable of being shortened by buckle. They are softly padded with horsehair in the middle and covered with wash leather : each carries an iron ring, h. On first suspending a patient the running cord, g, should be at its shortest, the centre cord, /', at its longest. Fig. 105. Sayre's .Tury-Mast Apparatus —a. Two pieces of malleable iron bent to fit the curve of the back. 6. Three or more roughened strips of tin attached to iron, long enough to encircle the body. c. Central shaft carried in a curve over the top of the head and capaMe of being elongated at will, springing from cross-pieces of n. |ilit'(l Ky tlir ulnar nt'ivc. When 1 saw liiin. two days afterward, tliesi' syni|>tain appeareil at tin; time, hnt three hours later pain and nnmliness showed themselves, and at this time some thickenin;r over the spot could he made out. In the course of three weeks these .symjitoms di.sappcared and recovery was eoinph'te. In this case it would appear as if some hemorrliajre liad taken place into the nerve sheath, {livinir rise to the jiaralysis. wliiidi disajipeared as the hlood was absorhed. Wounds of Nerves. When a nerve is vouinhil, pain is produced ; and this may be of a passinj^ (jr more permanent (diaracter. In nervous, hysterical suV^jects the nerve pain is .sometimes severe and persistent, and is then called "* neuralgia. It may be confined to a branch of the injured nerve or it may involve the whole trunk. Wlu'u a nerve is dividtd. coin})lete paralysis of the i>arts sujjjjlied V>y it follows. It may. however, reunite and recover its functions. Paget has related a case of complete division of the meilian nerve in which the trunk had nearly recovered its conducting power a month after the wound. I have seen a similar case in which recovery ensued in four months. The following is another example in point : A woman ;ct. 'M) came to me with an incised wound behind the inner condyle of the humerus. The ulnar nerve had been divided, and there was complete paralysis of motion and sensation of the parts sup- plied by it. The edges of the wound were adju.sted and the arm placed in a sling. A month later .she returned with a burning pain in the little finger, which was really cold, but red, swollen, .shining, and blistered ; and when touched, some slight sen.sation was produced. Cotton-wool and oiled lint were applied, and the arm was fi.xed upon a straight splint. The original wound had nearly healed. In two weeks the finger looked natural ; sen.sation in it and all other pai'ts supplied by the nerve had improved. In another month she returned with the old symptoms as l)ad as ever. They had reappeared upon the removal of the splint two weeks previously, but on its rcapplication with the cotton-wool they again disappeared. The splint was then kept on for two months, when sensation became natural, complete repair having taken place in four months. When seen six months later, she was still well. The red, swollen, shining, and blistered condition of a finger deprived of nerve force is characteristic, and is generally a.ssociated with the sensation of a burning pain and loss of temperature, amounting sometimes to a depression of 9° or 10° Fahr. There may likewise be a curving of the nails, as seen in phthisis, or ulceration of their roots. These symptoms are clearly due to malnutrition. When the nerve repair does not take place, these .^symptoms are very apt to return from time to time on any change of tem- perature or depression of the general power of the patient. Joint Affections. — The joints of /imhs in which the nerve supply has been inter- fered with, after injury undergo a change which consists essentially in a painful swelling of these joints, which may attack any or all of the articulations of a member. It is. says Mitchell, distinct from the early swelling due to the inflammation about the wound itself, although it may be ma.sked by it for a time ; nor is it merely part of the general oedema which is a common consequence of wounds. It is more than these — more important, more persistent. Once fully established, it keeps the joints stiff and sore for weeks or months. When the acute stage has departed, the tissues about the articulations become hard and partial anchylosis results ; so that in many cases the only final cause of loss of motion is due to this state of the joints (W rj's aj'I'ENDAges. 255 en APTKK VITT. DISEAS l-:s A N I » I N.I I I ; I lis ( » I" T 1 1 K HYE, ETC. Hv CIlAin.KS IIHi(ilN.S. EXAMINATION OF THE EYEBALL AND ITS APPENDAGES. The exaniiiiatioii of the eyeball will be coiisideretl under lour heads: 1st. By the unaided eye. 2d. By lateral illuniinati(tn. 3d. By the iiphthahnoseupe. (a) Direct examination. (/<) Indirect exaniiiuitiou. 4th. By manipulation. The rtfrxctitiii of the eyeball, the field of vision, etc.. will also receive a .short notice. I. Examination by the Unaided Eye. In order to examine the outer surface of the eyelid.s, ocular conjunctiva, cornea, anterior portion of sclerotic, aqueous chamber, and lachrymal apparatus, it is necessary to place the patient in a jrood light (as before a window) and direct him at first to close the eyes, then open them widely and look by turns in different directions. To examine the palpebral conjunctiva it is necessary to evert the upper lid and to draw the lower one downward. Ever.sion of the upper lid can be accomplished thus: The surgeon, standing in front of the patient, should direct him to look downward and close the eyes ; he should then place the forefinger of one hand upon the lid at the attached or upper border of the tarsal cartilage and make gentle pressure downward and backward, so as to cause the free edge of the lid to stand away from the eyeball, then place his thumb beneath the margin of the lid and make a slight upward movement, at the same time continuing the pressure with the finger ; by this means the lid will be made to turn u])on itself and become everted. The lid may also be everted by pre.ssing a probe horizontally upon its outer surface and drawing it upward by means of the lashes, at the same time making pressure downward with the probe. To examine the conjunctiva covering the lower lid. all that is necessary is to place the finger upon the margin of the lid and draw it strongly downward, when its conjunctival surface will become exposed. Normal Appearances. The outer surfiice of the eyelids is covered by soft, delicate skin, which is thrown into folds on every contraction of the orbicularis ; their free margins are of some thick- ness. From the outer edge of this free margin project the lashes in two or three rows, those of the upper lid being thicker and longer than those of the lower. The la.shes extend along the whole outer edge of each lid, but are much fewer and more delicate in that portion extending from the tear punctum to the inner canthus. The inner edge of each margin is occupied by the orifices of the Meibomian glands, which are seen as a close set of yellowish points. T/ie ocular coiijuucfini is smootn. moist, .shining, and transparent, allowing the white sclerotic to show plainly through it ; a few vessels are generally seen running from the outer and inner canthi toward the cornea, but these are perfectly consistent with a healthy condition of the membrane. The caruncle and semilunar fold occupy the space immediately external to the inner canthus. the former appearing as a small reddish-gray projection, the latter as a well-defined pinkish fold. The palpebral covjimctiva is also smooth, moist, shining, and transparent, and appears to have somewhat of a yellowi.sh color, from the tar.sal cartilage, to which it is closely and evenly united, showing through it. That portion of conjunctiva reflected from the lids to the globe {fornix) appears somewhat thickened and wrinkled and is slightly more vascular than the ocular and palpebral portions. Parts requiring Special Notice. — Certain parts of the conjunctiva require to 256 EXAMINATION OF THE EYEBALL AND ITS APPENDAGES. be specially examined. The portions next the thickened margin of the lid, the fornix, and about the caruncle are the most likely situations for the lodgment of a foreign body. That portion covering the attached border of the tarsal cartilage also should be noticed, as it is here that granular ophthalmia manifests itself most plainly. The cornea is smooth, shining, and perfectly transparent throughout, except in the case of old people, in whom a bluish-white rim (arcus senilis) is often seen occupying more or less of the structure, somewhat within its margin ; no blood vessels are seen on its surface or in its substance. The anterior jyort ion of the sclerotic is pearly white or of a pale bluish tint and shining. It is plainly visible through the transparent conjunctiva covering it; some fine vascular twigs may occasionally be seen traversing it in front of its equatorial region. The aque- ous chamber is filled by the aqueous humor, which is transparent, colorless, and of such quantity as to preserve the proper curvature of the cornea without causing tension or allowing of laxity, and to keep it separated from the iris by a considerable interval. The iris varies in color in diiferent individuals ; it is bright, shining, and marked by slight radiating ridges around the pupil ; it presents in health no appearance of blood vessels. Its plane is exactly vertical ; the pupil, situated somewhat to the inner side of the centre of the iris, is perfectly circular and dilates and contracts quickly with vari- ations of light. The examination of the lachrymal apparatus gives chiefly negative results ; the posi- tion of the tear puncta closely in contact with the ocular conjunctiva must be noticed ; pressure with the finger over the lachrymal sac causes no escape of fluid through the puncta, neither can the lachrymal gland be felt or seen in a normal condition of the parts. n. Examination by Lateral Illumination. By this method all the parts mentioned above are seen more clearly ; minute foreign bodies, slight opacities of the cornea, etc., which might be overlooked in examining with the unaided eye, are discovered, and in addition the whole of the lens and the anterior portion of the vitreous can most satisfactorily be looked into. The method of examination should be as follows : The patient should be seated in a dark room (the pupil having been previously dilated with atropine) and a lamp placed at abovit two feet distance on the left and rather in front of his face. The surgeon should stand nearly in front, or rather to the patient's right side, and facing him ; he should then take in his right hand a bi-convex lens of about 2i inches' focal length.* and with it con- centrate the light on the surface of the cornea ; with a little manoeuvring he will find that he can thi'ow the light through the pupil to a considerable depth into the eye. The patient should be told to look in various directions, so that all parts of the anterior por- tion of the eye may be examined. Results Obtained. — The results obtained by lateral illumination are chiefly nega- tive. The lens in health is perfectly transparent and in youth is nearly colorless, but some bluish lines showing its division into diff"erent segments can be recognized by care- ful examination. As age advances these lines become more marked and the whole lens appears of a bluish-gray color, though its transparency is still unaff"ected. Behind the lens all appears dark, but any tumor, hemorrhage, etc., occupying the anterior part of the vitreous would be discovered. It should be noticed in the examination by lateral illumination that opacities of the cornea, etc., always appear with greatest distinctness on the side which is farthest from the light. A second lens may also be used to magnify the parts illuminated by means of the first. in. Examination by the Ophthalmoscope. Description of the Instrument. — The ophthalmoscope, as used at the present day, consists essentially of a mirror of silvered glass or polished metal having a central opening, with certain accessory portions in the shape of convex lenses of different foci, used as objective lenses, clips and other contrivances for holding ocular lenses behind the sight-hole of the ophthalmoscope, together with the ocular lenses themselves. The oph- thalmoscope since its introduction has undergone innumerable modifications, both in prin- ciple and detail, the number of diff'erent instruments now in use being nearly or quite as great as that of ophthalmic surgeons. ^ A lens of 2| inches' focal length is about equal to one of sixteen dioptrics in the metrical svstem. (H'liril ALMnscoriC /•;.V.1.1//.V.I770.V. 257 Fig. lOG. Till' IlKist USfl'iil t'linii nf (i|ilitli:illiin>rii|)c IS tli.it n\' I ii el ircidi ; tlic latest liioililiciition (Fi<,'. Hit!) (if this iiistniiMciit cdiisists on the metal hack is fixed a clip for the j)nrpo>e of holilini:; an ocular lens; the hack is screwed to a liandle ahout U 1 inches lonj;. The acces- sorv jxirtions consist of t\V(t ohjeet lenses of 21 and '.'» inches" local leiijrth respijctively,' autl live ocular lenses — two convex, of (I and 12 inches positive foci /^ three concave, of S, 12, and 24 inches nepitive i'oci ;'' all are made to lit into the ahove-mentioiied clip A Verv convenient case contains the whole. Method of Using the Ophthalmoscope. — There are two methods of usinp tliis instrument. The lirst, which re(|uires much |iracticc, i.s called the direct method of examination, or examination of the im/ iiiiiuj>\ with the ophthalmoscope alone, witliout" the aid of a hi-coiivex ohjeet lens. The secoiul, which is much the easier of the two. is called the indirect method, or examination of tlic Inverted imaeje ; in it hotli tlie ophtlialmoscope and a bi-convcx lens are used. Direct (//i/il/id/Di'isiiijiir Kxaniiiudion. — In this method a virtual erect image situated behind the eye is seen. The examination is conducted in the followiii'.'' manner: The patient being seated in a dark room, a gas or other lamp (gas being preferable) should be placed at the side corresponding to the examined eye, on a level with it, but so situated as to leave the cornea in shade ; he should then be directed to look forward and a little upward, at some distant object, and to keep the eyes as steady as possible. Supposing the right eye to be examined, the lamp should be placed at the patient's right side ; the observer, standing in front at a distance of LS inches or 2 feet, should take the ophthalmoscope in his riglit hand, look through the sight-hole with the right eye, and reflect the light from the lamp through the pupil of the patient's right eye. If the examination be conducted properly, the pupil will appear of a bright-red color. The observer should then look for the optic disc, which is situated rather to the inner side of the axis of the eyeball ; he will know that the disc is in view from the alteration in c(jlor of the pupil, which will turn from red to white or pinkish white. Having obtained the peculiar reflection of the optic disc, the observer (taking care to relax his own accommoda- tion) should approach the eye until an interval of only 2 inches separates his cornea from that of the examined eve. Some difficulty Liebreich's Ophthalmo- . . , . , "^ "^ scope will be experienced in keeping the eye illuminated, increasing as the distance between the observed and the observer becomes less ; this, however, will be over- come by practice. When the observed eye has been approached to within a distance of 2 to 8 inches (supposing both the examining and examined eye to be emmetropic), a dis- tinct erect and greatly magnified image of the parts occupying the fundus of the latter should be obtained ; most observers will, however, find the image sharpened in outline and detail by using a weak concave lens behind the sight-hole of the ophthalmo.scope. Should either the observer or the patient be myopic, it will be found necessary, in order to examine the erect image, to place behind the sight-hole of the ophthalmoscope a con- cave lens which rather more than neutralizes the existing ametropia. The examination of the erect image, although requiring considerably more practice than that of the inverted, should never be neglected, as it gives much more satisfactory evidence of minute changes in the fundus oculi, all the parts being seen liighly magnified (about fourteen and a half times). It gives, however, a less extensive field of vision, on account of the size of the objects, wdiich only allows small portions of them to be seen through the pupil at one time. The optic disc, retinal ves.sels, and other parts occupying the fundus should be exam- ined by looking in different directions through the pupil, the observed eye being kept steadily fixed during the examination upon some distant and suitably situated object. The right eye having been examined, the lamp should be placed on the patients left side aud the manaMivre repeated, the observer using the left hand and left eye instead of ' Sixteen and thirteen dioptrics, metrical system. ^ Ahout .'ieven and three dio])trics, convex. ^ About five, tliree, and one decimal five, dioptrics concave. 17 258 OPHTHALMOSCOPIC EXAMINA TION. the right hand and right eye. The condition of refraction of the eye can be diagnosed by the direct method of examination. Indirect Ophtludmoscopic -Examination. — In this metliod of examination an inverted aerial image of the fundus oculi is formed by the interposition of a bi-convex lens between the observer and observed eye. (See Fig. 107.) Fig. 107. A observer's. B observed, eye. F, the light. S, the mirror. L, the biconvex lens, a fi, some portion of the retina or the disc, a' /3', its inverted aerial image formed between the mirror and bi-convex lens. (From Carter's trans- lation of Zaiider on the Ophtlialmoscope.) The position of the patient and observer should be the same as for the direct exami- nation ; the same lamp also can be used, but should be placed rather farther back and kept on the patient's left side during the examination of either eye. The ophthalmoscope should be held in the same manner and the light reflected through the pupil as detailed above ; but, the red I'eflection having been obtained, the observer must not approach the eye, but remain at a distance of about 18 inches. The patient should be directed to look at some distant object so situated that the axis of the observed eye is turned slightly inward; this brings the optic disc (which lies some- what to the inner side of the optic axis) opposite the ophthalmoscope, and its peculiar bright reflection will be at once ob.served. The bi-convex lens should then be held in front of the observed eye at a distance about equal to its own focal length from the cornea, and steadied by the observer resting his ring-finger and little finger on the patient's brow. By this means an inverted image of the optic disc and vessels of the retina is immediately seen, which, although apparently within the eye, is in reality formed in the air between the observer and the bi-convex lens, and (in emmetropia) at a distance from the latter corresponding to its focal length. If the image of the disc appear indistinct, the observer may be sure that his own eye is not accommodated for the distance at which the image is situated, which is, in reality, shorter by some inches than it appears to be. Should this be the case, the observer must increase the ten.sion of his accommodation or withdraw somewhat farther from the observed eye. A better method, however, than either of the foregoing is to employ habitually behind the sight-hole of the ophthalmoscope a convex ocular lens of about 10 or 12 inches' focal length. If this be done, a clear and well-defined image will always be obtained without tension of accommodation, provided precautions be taken that the distance between the observer's eye and the image be not greater than the focal. length of the convex ocvlar lens. The disc and parts immediately surrounding having been examined, the patient should be directed to look straight forward, so as to bring the region of the yellow spot opposite the ophthalmoscope ; this having been carefully examined, the eye should be turned upward, downward, to the right and left, so that all parts of the fundus ma}' be exam- ined in turn. In the indirect method of examination the observer should use his right eye and hold the ophthalmoscope in his right hand and the bi-convex lens in his left in examination of the right eye, and vice veraCi in examination of the left. Difficulties of Opthalmoscopic Examination. Considerable practice is required in order to become proficient in the use of the ophthal- moscope ; the beginner will be frequently much disheartened at his want of success. Some of the difiiculties are only to be overcome by practice ; others are easily remedied. Reflections of the mirror from the two surfaces of the object lens often prove very troublesome ; the inconvenience ari.sing from this source is obviated by holding the lens ^ Four or three dioptrics. OrilTllALMOSCOPia EXAMISATlnX. 259 KoiiR'wliat ()l)li(|uely, wlu-ii tlio two iiiia^(!.s will recede from each other and leave a clear .space Ix'twffii tlu'iii. llefleetioii IVnm the surface of the cornea may he trouhlesoine, hut can n>u;ill\ lie overcome hy a little nianr this purpose a solution of one grain to one ounce of water should he dntpped into the eye ahout half an hour hefore the examination is made, or the patient may he ordered to use a solution of (tne-eighth grain t")v 111' nlVailidH hy diirrt uplil iKilinuMopic i-xaiiiiiiution we act upnii the .same priiu'ijde as in the diairuosis by trial with lenses — with this exception, however, that we use uur own eye as a t»'st, instead ol' tlu- patient's vision. .\s stated at p. li")", nntliinjr lA' the details (d" the I'limliis i»t' tin- «iiiin<'tropic eye can he i/nii/i/ made out until we have approached it vi-ry near. Now, on the (••mtrary, should any object occupying; tin- fundus lie ilnirli/ srm whilst we are still separated fnim the observed eve by a considerable interval, we may be certain that we have to deal with an anomaly of relVaction. The ((uestion now arises, Is the ea.s(! one of hypernuttropia or myojiia ? Wosition. If till" former, the eye is hypermetropic; if th(! latter, it is myopic. We can ascertain the position (d' the imajre l)y moviiii: our head from side to side. If the imajre be erect it will move in the same, if invcrtcil in an opposite, direction to the niovement.s of the head. If wt- wish to ascertain the amount of hypermetropia or myopia present, we take one of the ophthalmoscopes mentioned below, go a.s close as possible to the patient's eye, revolve the lens containinj; discs placed at the back of the in.strument until we have ascertained, in hypermetropia the strongest convex, in myopia the weakest concave, len.s with which we can still see clearly the optic disc and retinal vessels. The number of diojUrics of the strongest convex or weakest concave lens with which the greatest attainable acuteness of vi.sion /or distant letters is .still maintained expre.sstf.s what is known as the degree of '• ametropia'." Thus, we say that an eye which sees a.s clearly or more clearly through a convex lens of two dioptrics has a hypermetropia of 2 I), an eye of which the acuteness of vision is most improved by a concave len.s of three dioptrics has a myopia of H I), and so on. The same holds good in the measurement of anomalies of refraction by the ophthal- moscope. The strongest convex lens in a case of hypermetropia, the weakest concave in one of myopia, through which a clear view of the fundus can .still be obtained, expresses the degree of '" ametropia " present. Two very u.seful ophthalmoscopes by means of wliich anomalies of refraction can not only be diagno.sed, but also accurately measured, have been devised — one (Fig. 109) by 3Ir. Charles J. Oldham of Brighton (see Report of Fourth OpIttJialmic Cotir/ress, Via. 109. 1872), and another by Mr. W. L. Purves ; the latter is, I think, the more convenient of the two.' The third method of ascertaining the form, and also the degree, of ametropia by '• keratoscopy,"' is conducted as follows : The patient, being seated, and the lamp placed rather behind the level of the face, is directed to look straight forward. The observer should stand or sit at a distance of about a metre and a quarter, and with the ophthalmoscope reflect the light from the lamp upon the patient's eye. As soon as the bright red reflection of the fundus is seen the mirror should be rotated. If ametropia be present, a shadow will be seen to pass across the illuminated area. The diagnosis of the anomaly present is decided by the direction of this shadow. If it passes in the same direction as the rotation of the mirror, the eye is myopic ; if in the opposite direction, the eye is hypermetropic. In slight degrees of ametropia and emmetropia the shadow is so faint as to be made out with difficulty ; if seen at all, it moves in the same direction as the mirror in slight M, slight H, and E. ^ Many other refraction ophthalmoscopes are in use, but the two mentioned, and another smaller and cheaper instrument known as Loring's oplulialnioscope, will be found as useful as any. Oldham's Ophthalmoscope. 264 DISEASES OF ACCOMMODATTOX. We can ascertain the degree of anomaly present by finding, in myopia, the weakest concave lens which, held before the eye, makes the shadow begin to move against the mirror ; in hypermetropia, the strongest convex lens which causes the shadow to begin to move with the mirror. In the examination of refraction by keratoscopy it is well to have the pupil and accommodation fully under the influence of atropine or other mydriatic. The observer must be naturally emmetropic or made so artificially. The TREATMENT of anomalies of refraction consists mainly in neutralizing the defect by suitable spherical lenses. We must, however, in myopia take care not to give too strong glasses. For further information on the subject of refraction the reader is referred to works treating specially of ophthalmic subjects, more especially to that on The Accommodation and Refraction of the Eye (DondersJ. Accommodation. By accommodation is meant the power which the eye possesses of altering the condi- tion of its refractive media so as to form upon the retina images of near objects the rays of light from which are divergent equally as distinct as images of more distant ones the rays of light from which are parallel or nearly so. The power of accommodation depends upon the elasticity of the crystalline lens, the curvature of which can be increased to a considerable extent ; the alteration of curvature is brought about by the action of a ring of inorganic muscular fibres situated between the sclerotic and choroid, just external to the greater circumference of the iris. This ring is known as the ciliary muscle. The manner in which the ciliary muscle acts upon the lens is as yet a disputed point, one theory being that the lens is m'aintained in a flat- tened condition by tension of its suspensory ligament so long as the eye is adjusted for a distant object — that upon accommodation for a near one the ligament is relaxed by con- traction of the muscle and the curvature of the lens (more especially that of its anterior surface) increased by virtue of its own elasticity. The other theory is that the ciliary muscle compresses the lens in some manner and so alters its curvature. Range of Accommodation. . We speak of the range of accommodation, and by it we mean the power of a lens, which we suppose the crystalline adds to itself when we change our look from the far- thest to the nearest point of distinct vision. Thus, an eye which sees clearly at infinite distance when its accommodation is relaxed, and at 16 centimetres with greatest ten- sion of accomiuodation. has a ranae or " amplitude " of accommodation equal to a lens of iJ)_o = 6 D, about. Accommodation is accompanied by convergence of the optic axes from the action of the internal recti muscles and by contraction of the pupil. Diseases of Accommodation. Paralysis of accommodation is met with in cases of paralysis of the third nerve accompanied by ptosis, divergent strabismus, and more or less dilatation of the pupil; it may be caused by injuries, as blows on the eyeball itself or in its vicinity; sometimes it is met with without apparent cause, not unfrequently in persons recovering from diphtheria or from any exhausting disease, and accompanied by no paralysis of the external ocular muscles ; it can always be produced artificially by the use of atropine or other mydriatics. Symptoms. — Dilatation of the pupil, general mistiness of vision, and inability to see near objects plainly, the last condition being capable of correction by the use of a con- vex lens. Treatment. — This depends on the cause ; if the paralysis of accommodation be associated with paralysis of other branches of the third nerve, the treatment must be directed against any existing constitutional condition — syphilis, rheumatism, etc. — most improvement being brought about by the use of iodide of potassium in increasing doses, alone or in conjunction with bichloride of mercury. If dependent on injury, the eye should be kept bound up and inflammatory .symptoms treated as they arise. If arising idiopathically, without apparent cause, a solution of sulphate of eserine should be used /•7/;/./> OF VISION. 265 twii i>r tliroe times a day in order to stiiimlate the oiliary mu.scle to contract, and attfii- tiiiii |i;iid to the pMieral health. In any case, a convex h-ns may he used if rcfiuired. Spasm of acCOinmodation is met with in sinm- cases of liypermctropia, and occasionally in myopia; it ut'ten masks a cdn.sidcrahlc amonnt of hypermetro|iia, and may at times (^ven make the eye appear to he my<>]»ic. If it exists with myopia, tin; de the general health. Inflammation of the eyelids niay occur during or after acute diseases (measles, TITF fnyjiwcTiVA. 267 scarlatina, etc.), in the course of erysipelas, as the result of injuries, or in cr)iineetion with severe in flam mat ion of uei^'hhoriiij,' parts; «.//., purulent ophthahuia. The swelliiif; and redness are usually considerable and the eye cannot he opened ; the inflaniiuation gener- ally ends in resolution, hut may (especially it' it result I'rom measles, scarlatina, etc.) j^o on to the formation uf abscess, or even to sloujrhinjr of the skin. 'rKKAT.MK.NT. — iiOcally. fomentations with hot water nr decoction of jxippy-heads ; if an aliscess form, it should be opi-ned — preferably thmuLdi the conjunctiva. 'file patient s ucueral health shouhl also be attended to. Stye (."hordeolum") is a small red and painful swellin<^ situated on the o\iter surface of the lid or near its inar<.,'iii, and consists in a circumscribed inflammation of the lid dependent on morbid chanuc in the .Meibomian jrlands. Styes frenerally occur in weaklv, delicate persons ; several may appear siujultaneously, or there may be a .succes- sion of them ; they s.sil)Ie, a fjotKl view of the cornea should be olitaiiH'd. as its contlition niaterially iiifliienccs the ])ro<.MH»sis with rejranl to si^'ht. The exuniinatiiin slioiilil l»e made with eare, as the cornea may be rnptiired whilst making it. In ophthalmia nt'oiiatornm the only treatment retjuired is to wash out the eyes every liour t»r half hour with stronjr alum lotion (see j). 2(i8j until the diseharj^e is lessened; the lotion need oidy be useil thus lVe([uently for twelve hours . .M.i, the chilli beintr allowed to sleep ut nijrht ; as the discharge gets less the lotion mav be used less frei|uently. Some simple ointment slmuld bt; applied to the margin of the lids once or twice a day to keep them from sticking together. Slight cases of jiurulent ophthalmia in older persons may be treated in the same manner, but the more severe forms (especially the gonorrhtcal) reijuire that much more energetic measures be taken. The treatment should lie both local and constitutional. Local Trrafnif'iif. — When the jiatieiit is first seen, the lids should be everted and the whole conjunctiva brusheil over with a stick of solid nitrate of silver or ))ainted witli a solution of forty to si.xty grains of the salt to .5J f»^' water; tlic application should be repeated in the course of two or three days if no improvement have taken place. The patient should be kept lying down in a dark room and a bag of ice or lint kept wetted with iced water a])plied over the closed lids ; the ice or lint should be removed and the eves washed out every liour or halfhuur with some astringent or antiseptic lotitjn. the greatest cleanliness Vicing observed. Should there be much pain and the patient be strong, blood may be taken from the temples by leedies or the application of the artificial leech ; but, as before stated, most ])atients suffering from severe purulent ophthalmia are mucli depressed and will not bear depletion. Omstifiifi'Hiti/ Tre'itmnit. — The free administration of tonics, especially iron and quinine, with gootl living and a fair amount of stimulants. If perforation of the cornea threaten or have taken place, the eye should be kept firmly l)andaged. so as to prevent as much as possible any escape of the contents of the globe. Diphtheritic Ophthalmia. — This form of ophthalmia is but rarely met with \i\ London [or America] : it affects persons of all ages. At first sight the case appears to be one of severe purulent ophthalmia ; its chief characteristic, however, is a solid infil- tration of the substance of the conjunctiva, with or without the formation of diphtheritic membranes on its surfjice. The affected eye is frei(uently lo.st from implication of the cornea. The disease is best treated by sedative applications, as fomentations of poppy- heads, or belladonna, attention being paid to the patient's general liealth. Injuries. — Wounds of the conjunctiva usually heal readily enough, requiring only simjde treatment. Biinis are usually caused by contact of lime or hot metals ; the damage done may be only slight, or the whole conjunctiva and cornea may be converted into a dead white slough. Treatment. — The conjunctiva should be carefully examined and all foreign bodies and portions of sloughy tissue removed; should the injury have been caused by lime, the surface of the conjunctiva must be carefully cleansed with a weak solution of acetic acid or simple warm water. Some oil should be placed between the lids and the eye bound up with wet lint and a bandage. If any symptoms of iritis appear, a solution of atrojiine shotdd be dropped into the eye from three to six times a day. Should there be much discharge, alum lotion may be used. When the sloughs have separated, care must be taken to prevent adhesions between the raw surfaces left by passing a probe between the lids and eyeball once or twice a day and directing the patient to draw the lid away from the globe frequently. Fureign bodies — small pieces of coal, iron, etc. — are sometimes found embedded in the conjunctiva, and must be removed. Ilemorrhiuje into the substance of the conjunctiva or beneath it may occur spon- taneously or from injury ; no treatment is necessary. The patient may be assured that no harm will come of it. and that the blood will disappear in the course of a week or longer. EXTERNAL MUSCLES OF THE EYEBALL. StraV)i>inns will lie considered in the next section. Nystagmus signifies a peculiar involuntary quivering motion of both eyes, dependent on rapid contraction of antagonistic pairs of muscles. The disease is usually 272 THE CORNEA. developed in infancy, and is always associated with considerable impairment of vision, arising from congenital cataract, opacity of the cornea after purulent ophthalmia, atrophy of choroid, etc. Nystagmus occurs in some nervous disorders, as locomotor ataxy ; also in persons who work in bad light, as those employed in mines, when it is described as '' miners' nystagmus." Treatment. — Nothing can be done to remedy nystagmus in the two first classes of cases, but miners' nystagmus may be entirely cured by removing the patient from his work and the administration of tonics. Paralysis and Paresis. — Paralysis signifies total loss of power of the affected muscle ; paresis, only partial loss. The symptoms of paralysis and paresis are double vision and total loss or impairment of mobility of the eye in some particular direction. The causes are affections of the brain or spinal cord ; disea.ses within the orbit, as tumors, nodes, or inflammatory exudations, pressing on the nerves supplying the mus- cles ; and affections of the nerves themselves or of the muscles. As a rule, the cause of the paralysis or paresis can only be conjectured, but very many cases will be found con- nected with syphilis. Treatment. — A careful inquiry should be made into the patient's previous history, and remedies given in accordance with this, those of an anti-syphilitic nature being gen- erally required. If the affection has not lasted more than tliree months, a favorable prognosis may be given ; but if, on the contrary, it has existed six months or more, recovery is very improbable. Paralysis of all the external muscles of the eye. " ophthalmoplegia externa " (Hutch- inson), is occasionally met with. The eye looks nearly straight forward and is almost immovable ; there is partial ptosis. The disease is probably of syphilitic origin, but is little influenced by treatment : it is often associated with symptoms of serious central disease. Insufficiency of the internal recti muscles gives rise to somewhat obscure symptoms, which have been mistaken for manifestations of cerebral disease. Patients thus affected complain that they cannot do near work for any length of time, as objects looked at become indistinct or appear double. They suffer from giddiness and pain in the brows and head generally. In.sufficiency of the internal recti should always be suspected if in a case of hypermetropia relief cannot be given by the use of glas.ses. Treatment. — Any anomaly of refraction should be accurately neutralized and the weakened muscles assisted by the use of prisms, or of spherical lenses so arranged as to have a prismatic action. THE CORNEA. Inflammation (corneitis, or keratitis). — Five different forms of inflammation of the cornea are met with: (1) Simple corneitis; (2) interstitial or ])arenchymatous corneitis; (3) pustular corneitis; (4) keratitis punctata; (5) corneitis with sloughing or suppuration. Symptoms. — Corneitis is characterized by watering of the ej'e, impairment of vision, intolerance of light, and pain, at times severe, at others insignificant ; on examination more or less of the cornea will be found cloudy or quite opaque, and blood vessels may be seen in its substance or on its surface. Diagnosis. — It is of importance to notice the course and position of the blood ves- sels in any case where the cornea has become vascular. Should the vessels lie altogether in the cornea, commencing near its margin and passing for a variable distance in its substance, the case is probably one of interstitial keratitis ; but should the vessels be continuous with those of the conjunctiva, pass over the margin of the cornea, and lie superficially on its surface, the vascularity is probably due to mechanical irritation from granular lids or inverted lashes, and the condition known as pannns is present. It is very necessary that the difference between these two forms of vascularity should be recognized, as their treatment varies widely. In the former case the treatment of keratitis, to be presently described, should be adopted; in the latter, treatment must be directed against the cause of the vascularity (granular lids. etc.). Simple corneitis may be caused by injuries or the lodgment of foreign bodies on the surface or in the substance of the cornea. There is some pain, intolerance of light, and lachrymation. and .some part of the cornea is found occupied b}' a halo of dulness. Interstitial or parenchymatous keratitis (corneo-iritis. syphilitic keratitis, keratitis, diffuse keratitis, A'ascular corneitis). — Interstitial keratitis occurs as a rule in consEiris. 273 persons will) are affootod by hereditary sypliilis : it is frequently, but by no means invariably, associated with ehau^es in the teeth, peg^red canines, notched incisors, or dome shape'of first molars ; flattened nose, fissures aroiiml tin- angles of" the nioutli. or other manifestations of (Congenital syphilitic disease. It usually first makes it.s apjiearance between the fifth and ei^diteenth years, but ha.s been seen as late as thirty ; it always afi'eets both eyes, either simultaneously or at short intervals ; it runs a very chronic course and is most intractable, a .severe attack often lasting from twelve to eighteen months. Sv.Mi'ToM.-^. — Interstitial keratitis ])re.sents all the symptoms of inflammation of the e(»rnea in a marked degree. The opacity is peculiar, and is caused by iiitiltrati(»n of the substance of the conu'a with opaipie material. At first the cornea becomes spotted in its centre, but the spots .s(jon run together, forming a grayish haze ; opacity then ccjmmences at the up|ter and lower corneal mar- gins and gradually sprea iilccin ari' visiltlf t'iniu<:h ; they may l)e ol" any size or riuinhfr. At tinii-s tliey a|)|>i'ar to l»e healing ; in wliifli ease, the ed^res a|){iear Mnooth and tht; surface of the uh-er roufrh and oiKKjue or chmdy. At others they are indoh-nt, and a;.'ain they iiiav he spreadinir. when their ed;;es are found to he elean cut. as if u piece iif tlie c«»rnea had lifcn piincheil out hy some sharj) instrument ; the surface of the uh-er appears ^hissy and is often deeply excavated. S/i>ii>f/iiiie renioveil by operation. ImU are very liable to reappear in their former site. Injuries. — Abrasions of the cornea niay be cau.sed by scratches from thorns, ends of straw, finger-nails, etc. They give rise to severe pain, much intolerance of light, and watering of the eye. Tre.\tment. — The eye should be kept carefully bandaged with lint soaked in bella- donna lotion till the abrasion has healed. Penetrating wounds of the cornea generally involve the iris or lens: in the former case an adhesion of the iris to the cornea (anterior synechia) is likely to be formed, or iritis set up : in the latter the lens will probably become opaijue. a traumatic cataract being developed. 276 STAPHYLOMA OF SCLEROTIC. Very extensive wounds of the cornea may allow the escape of the lens or vitreous. Treatment. — The eye should be kept carefully bound up with lint soaked in bella- donna lotion ; and in cases where the lens has been wounded or iritis set up a solution of atropine one grain to one ounce of water should be dropped into the eye from four to six or eight times daily. Should the lens swell and cause pain and increase of tension, it must be removed without delay or iridectomy must be performed. Iridectomy may have to be performed at some future lime for optical reasons or to obviate the irritation caused by dragging on an anterior synechia. Traumatic cataract may also rc(|uire to be treated. Burns of the cornea by lime, hot metals, etc., usually occur in conjunction with like injuries of the conjunctiva; they usually leave behind them opacities of greater or less extent and density, according to the severity of the injury, or may cause sloughing and destruction of the whole or greater part of the cornea. Treatment, the same as that of burns of the conjunctiva. THE SCLEROTIC AND EPISCLERAL TISSUE. Episcleritis. — Inflammation of the sclerotic or episcleral tissue, or more commonly of both together, is a somewhat rare disease ; it is characterized by the presence of purple swollen patches covered by enlarged conjunctival vessels and situated usually about the insertion of the recti muscles. The purple patches often disappear from one portion of the globe and appear again at another ; the inflammation is chronic in its course, but subsides after a time, leaving some discoloration of the afl'ected part ; it is very liable to recur. It occasionally follows operations for strabismus. Treatment. — Sedative applications, as decoction of poppy-heads or belladonna fomen- tation, should be used three or four times a day; and if there be much conjunctival vas- cularity or any mucous discharge, some astringent lotion, as chloride-of-zinc drops (see Formulae, p, 2G8), should also be employed. Any constitutional treatment that may appear called for should be adopted. In some cases tonics do most good ; others, again, may be greatly benefited by a course of mer- cury or iodide of potassium. This disease is usually described as " episcleritis." Stapliyloma. — A bulge of the sclerotic may occur from softening of its structure by inflammatory changes, which usually commence in the choroid. Staphyloma may be met with in the ciliary region (ciliary staphyloma), about the equator (equatorial staphyloma), or near the optic nerve (posterior staphyloma). Little can be done in the way of treatment. Gummata are occasionally seen upon the sclerotic ; they occur as vascular, well- defined bosses, either singly or in groups of two or three. Their diagnosis is not easy ; they are likely to be confounded with sai'coma or patches of episcleritis. From the former they can be distinguished by their course, which is, though slowly, toward recovery; from the latter, by being more aljruptly defined and raised above the surface of the globe. They are generally associated with syphilitic history, and often with other manifesta- tions of syphilis. They require vigorous anti-syphilitic treatment. Injuries. — The sclerotic may be wounded by sharp instruments or ruptured by blows ; in the latter case the lesion usually takes place in the ciliary region, near the upper mar- gin of the cornea. The sclerotic (as also the cornea) may be pierced by a .shot or chip of metal, which may be lodged within the globe or have pa.ssed clean through it. Treatment. — The treatment of injuries of the sclerotic depends much upon the extent and nature of the damage done. Small incised wounds will usually heal readily enough if the eye be kept carefully bandaged. Larger wounds may require to be closed by a suture. Blows often cause complete disorganization of the globe, the aqueous and vitreous chambers being filled with blood and hemorrhage having taken place between the sclero- tic and choroid, although no rupture of the external tunic has oceiirred. Such cases must be carefully watched and the eye kept bandaged with lint soaked in belladonna lotion. In cases of extensive incised wounds, large ruptures, or wounds as.sociated with lodg- rill-: ciiYsTM.i.isi: less. 211 iiii'iil iif ;i tun-iLni l)(i(ly witliiii llie ;:lul)c', rxlirpaliiui of tlie ('yeliall will jtiulialily hive to lie in'if'tiiim'tl. (Si'c i>. iiliJ). THE CRYSTALLINE LENS. Congenital Anomalies. — N'ariations in shape, ubsence of the wlnde (aphakia) or j.;irl III' I hi- liiis. and «li>|ihu(.iin'iit.s are met with as coiifreiiital defects. Presbyopia (old sij^ht). — I'resbyoitia depends on senile cliange of the crystalline lens. I»y which il is rendered harder than in youth and its elasticity is iniitaired. As a conse(|uence, its curvature can only be altered to a limited extent by the action of the ciliary muscle, and the power or raniie of uceonimodation is eorrcsj»ondin,> (if jMilisli of the iris, slu<^f^ishne88 or complete iiiiiiiol)ility uiul (as a rule) eoiitractioii of the )Mi|iil. iiijeetioii of tlic ciliary rej^ioii (ciliary reiliiess), wiiterinj:: of the eye, and iiiiitainiieiit of vision. ()ilicr symptoms met with oceasionally ure j)ain, intolerance of lijrht. irre<;ularity in outline of the pupil, intlammatorv i)ro(Jucts — pus or lymph nodules — visilile to the nakt'il eye. Three varieties of iritis are commonly nut with: I. Simple iritis; 2. Kecnrn-nt or rheumatic iritis; '.',. Svphilitic iritis. Simple Iritis. — All the more constant .symptoni.s of iritis are present, often accom- panied l»y more or less severe pain. An uncom])licated attack lasts from one to two weeks or longer, and usually ends in resolution, the iris (juite recovering its normal condition, but a few adhesions may form between the iris and lens capsule (posterior synecbijc). In this as well as in the other forms of iritis, however, the intiammation may run on to the fatient's previous history, ascertain the existence of other signs of syi)hilis. and make his diagnosis accordingly. Syithilitic iritis occurs most frequently between the ages of fifteen and forty, but is occasionally met with as a manifestation of congenital syphilis in infants, and often in cases of interstitial keratitis. Results of Iritis. — In many cases, especially if early and properly treated, per- fect recovery takes place ; in others, permanent signs of inflammation are left. The morbid changes more commonly met with are — 1. The iris it.self may be found utropJiicd. rhjitl, or rotten . and very prone to bleed freely on the slightest wound. These conditions become mo.st apparent when operating upon its structure. On attempting to perform iridectomy considerable diflftculty will be experienced in removing a portion of the iris, which may be so tough that none of it can be torn away or so rotten that only the portion included between the branches of the forceps is removed, or hemorrhage may take place to such an extent as to prevent the completion of the operation. 2. Adhesions to neiijlthor!nij parts (•• st/nechifr ") may have formed, those most com- monly met with being between the iris and lens capsule (" posterior synechias "). Posterior synechia) are generally situated at the jnipillary margin, and vary in extent from a few adherent tags of this part only to complete adhesion of the whole posterior surface of the iris to the lens cap.sule, this latter condition being known as "total posterior synechia.'' 280 RESULTS OF IRITIS. Adhesion of the iris to the cornea — •• anterior synechia '' (shouhl this occur at all as the result of iritis) — will be found about its greater circumference. 3. Closure of the p\ipll by inflammatory material ; opacities upon the hm-capsule caused by adhesion of the •' uvea "" detached from the posterior surface of the iris. 4. Dense inflammatory deposits in or beneath the capsule, or involving the superficial fibres of the lens itself {capsular cataract^, may also be met with. Treatment. — In treating iritis we must take care, Jirst, to remove any local cause, such as a foreign body, opaque swollen lens, etc., and to cure granular lids or remove inverted lashes ; secondly/, we must endeavor to dilate the pupil ; thirdly, to relieve pain ; /b»/-?/i/y, any constitutional treatment , that may appear called for should be employed. (The means of carrying out the first indication are detailed elsewhere.) Local. — In order to dilate the pupil a few drops of a strong solution (gr. iv to 5j) of sulphate of atropine should be placed between the eyelids by the surgeon himself at each visit, and a weaker solution (gr. \ to gr. 1 to Sj ) should be used by the patient from four to eight or twelve times a day. If the case is treated at the commencement, more or less dilatation of the pupil will usually take place; but should the iris have become infiltrated with inflammatory matter and adhesions formed, little or no efl^ect will be produced. The atropine should, however, be persevered with. Some patients are extremely intolerant of atropine ; in such it produces swelling and inflammation of the eyelids and face of an erysipelatous nature, known as '' atropism." If atropism occur, a'substitute must be found for the atropine. Daturine, hyoscyamine, duboisine, hematropin, or other mydriatics, may be tried, or the atropine may be used in the foi'm of an ointment, gr. \ of sulphate of atropine to 5j of vaseline. In one case I found, after all else had failed, that mixing gr. 1 of carbolic acid in 5j of atropine solu- tion prevented atropism. In cases of iritis with suppuration the eye should be fomented frequently with hot belladonna lotion and kept bound up with lint soaked in the lotion. In cases accompanied by much pain blood should be taken from the temples by leeches or the artificial leech. Atropine may give rise to pain by causing dragging upon adhesions, and should be used with cavition in cases where its application is attended by much suff"ering, especially if it have no efi'ect upon the pupil. The eyes should be pro- tected from light by a green shade or protectors until the inflammation has subsided. Constitutional. — Of constitutional remedies, there is none so useful in the treatment of iritis as mercury. The drug should be given, in some form or other, so as speedily to aft'ect the system in all cases where inflammatory products are plentifully produced, whether the inflammation be of syphilitic origin or not. A pill containing gr. ij of pil. h3'drarg. and gr. \ of pulv. opii may be taken three times a day and is a very conve- nient and eff'ectnal mode of administration. Mercurial inunction or vapor baths may be employed if preferred. If the iritis occur in debilitated states of the system or the inflammation go on to suppuration, tonics, as iron or quinine, should be prescribed, and a plentiful supply of good food given. Should there be much pain, opium must be given ; and it is well to prescribe the drug in conjunction with extract of belladonna or hyoscyamus. In rheu- matic iritis salicylate of soda in doses of gr. xv to gr. xxx three times a day often does much good. The reavlts of iritis, should they seriously interfere with vision, require the perform- ance of iridectomy or some one of the operations for artificial pupil. Iridectomy should also be performed in cases of recurrent iritis. The removal of a portion of iris in, some manner — probably by preventing dragging on adhe.sion.s — has a marvellous efi'ect in pre- venting recurrences. Injuries. — The iris may be cut. toi-n, or bruised, prolapsed through or adherent to the cornea in cases of penetrating wounds of that structure (see " Wounds of the Cor- nea"), or it may be separated from its insertion to a greater or less extent by concussion without external wound. Any of these injuries are liable to set up iritis, which may pos- sibly be followed by suppuration. Treatment. — The injured eye should be kept carefully bandaged with lint soaked in belladonna lotion ; and if much pain is complained of or infiammator^' symptoms arise, blood should be freel}' taken from the corresponding temple, either b\- leeches or the arti- ficial leech. As in ii'itis from other causes, the pupil may become blocked or extensive .synechite form, requiring operative interference at some later period. (See " Operations on Iris.") ciionoiniTis. 281 Hyperemia of Choroid. TiHToasoil vasciiliirit y nt' lln' clKPrnid is not iiiirrr(|iiciit 1 y nift with, iiinrc ('S|icciallv in iuyi>|iir |i('rsi)iis; it slimilil Ik- .«ii.'<|i('t'tf(l if a ifcliiij: of t'lilncss ami t(ii>i(iii of the eyes, aefdiiiiiaiiiftl hy wateriiit;' an>l iiitnU'raiiee of li^ht, i.s ciiiiiithiiiMMl of. ( )ii exaiiiiiiatioii with the uphthahiio.scupe iiicrea.seil retliie.ss of* tin- choroid (esjM'ciallv ot" that portion nearest tlie outer side of the optie dise) and some enhir^eiueiit of the (dioroidal vessels ean he made out; these ehaiiiics will, however, very prohahlv he over- looked hy an inexperienced ohserver. Trk.vtmknt. — The eyes should be ke])t carefully at rest, protected fium li^dit, cold diuu'hes employed, and all positions (as stoopini^ or hangiuii- the head) which cause con- gestion of the eyeballs carefully avoided; blood may be taken from the temples; and if •rlasses have been worn, their u.se must be discontinued. When tlie more acute symp- toms have ])assed otl", any anomaly of refraction must be carefully neutralized by suitable lenses. Inflammation of the choroid, "Choroiditis," occurs uiidcr much the .^ame conditions as iritis; it also phiys a ])rominent part in .sympathetic o])htlialmia and is not unfrt'(iuently associated with inflammation of the iri.s — '• choroido-iritis.' Two forms will be commoidy met with, simple and sy))hilitic. Sy.mI'TO.ms. — In all cases of choroiditis more or less lo.ss of transparency will be found. Pain, intolerance of light, impairment of vision, fulness of tlie veins emerging from the sclerotic in the ciliary region, ciliary redness, dilatation and sluggishness of the pupil, and increased tension of the globe are symptoms often met with in choroiditis, but are by no means characteristic of it. A diagnosis can only be made with certainty by examination with the ophthalmoscope. The changes seen in the choroid with the ophthalmoscope are. grayish or yellowish patches or spots of exudation surrounded by more or less redness (hyper;cmiaj, and at a later period patches of atrophy. The exudation may occur in one or more large patches or be distributed over the whole or greater part of the choroid in the form of spots, this latter condition being known as '• choroiditis disseminata."' We know that the morbid changes noticed are in the choroid, from their relation to the retinal vessels which pass in front of and are not oltscured by the opacity. SyphiUtic choroiditis (in typical cases) is characterized by the presence in the choroid of yellowish lymph nodules similar to those seen in syyjhilitic iritis ; but, as in the latter disease, typical cases are only occasionally met with, and we n)ust be guided by the same rules in forming a diagnosis. Choroiditis disseminata is syphilitic ; the atrophic changes left by it are seen in spots of white and dark dotted about the fundus, often combined with an irregular band of dirty white extending round the optic disc. These changes are frequently seen in the subjects of congenital syphilis; the choroidal disease is in many instances associated with floating opacities in the vitreous and may be looked upon as a certain indication of syphilis. Choroiditis is frequently associated with inflammation and opacity of the vitreous humor; the retina covering the affected portion of choroid is usually involved in the inflammatory change, and the optic disc may be implicated if choroiditis exist in its vicinity. Atrophy of the choroid, as above stated, frequently follows inflammation. The ophthalmoscope shows white or dirty white patches, or spots corresponding to the areas previously occupied by inflammatory exudation, caused by destruction of the choroid, allowing the white sclerotic to show more or less plainly through it. The atrophic patches are frequently surrounded by dark bo-rders, from accumulation of pigment which has been disjilaced by the inflammatory material. Inflammation of the ciliary portion of the choroid (ciliary body) is known as '• cyclitis." Cyclitis is characterized by redness and swelling of some part or the whole of the ciliary region, with considerable eidargement of the veins of the retina, choroid, and iris, and pain in the eyeball, aggravated by pressure in the ciliary region. Cyclitis may be caused by injury or may depend upon syphilis, inherited or ac(|uired. Softening and shrinking of the globe is very likely to follow, from impairment of nutrition, dependent on interference with the circulation of blood. Suppuration may also take place. Wounds implicating the ciliary region of the sclerotic should always be looked upon as much more serious than those of other portions of the tunic, as cyclitis is frequently set up by such injuries. Cyclitis is not uncommonly associated with iritis — • irido-cyclitis." 282 SYMPATHETIC OPHTHALMIA. Treat.mext. — The treatment of choroiditis should be very .similar to that of iritis. Iridectomy does good in some chronic cases or in those in which there is increase of ten- sion of the globe. For the atrophic changes no treatment is of much avail. Bone upon the Choroid. — Deposits of bone are not unfrequently met with upon the inner surface of the choroid in eyes that have been blind and shrunken for years. Tubercles in the Choroid. — In cases of general tuberculosis deposits of tubercle have occasionally been met with in the choroid. Injuries. — The choroid may be injured by foreign bodies entering the eyeball or ruptured by violence without perforation of the tunics. In the former case (more especially if a foreign body be lodged in the structure of the choroid) inflammation is very liable to follow, the eyeball being eventually lost by sup- puration or shrinking. A rupture of the choroid from external violence is attended with more or less hemorrhage, which fills the rent made in its structure with blood and may cause considerable displacement of the retina. Seen with the ophthalmoscope soon after the receipt of the injury, a ruptui'e of the choroid appears as a more or less elongated blood clot : later the blood becomes absorbed and a white linear figure is left, from the white sclerotic showing through the rent in the choroid. This form of injury is not often followed by destructive inflammation. Treatment. — Injuries of the choroid .should be treated in the same manner as injuries of the sclerotic, cornea, or iris, with belladonna lotion, lint, and a bandage. Sympathetic Ophthalmia. '• Sympathetic ophthalmia " is the name applied to a peculiar form of inflammation of the choroid, ciliary body, and iris coming on in one eye in consequence of morbid changes which have previously existed or are .still in operation in the other. The mo.st common cau.ses of sympathetic ophthalmia are injuries of one eye, especially vxninda implicating the ciliary region, or associated with lodgment of a foreign body in the interior of the globe. Shortly after the receipt of an injury the wounded eye may become affected by kera- titis punctata and choroido-iritis of a marhedly adhesive character ; pain moi'e or less severe will be complained of. sight rapidly lost, extensive synechias form, the tension of the globe — at first .somewhat above par — diminish, and shrinking of the eyeball follow. At an_v time during the foregoing changes in the injured eye the sound one may become irritable and painful, and a similar inflammation may be set up in it, leading rapidly to a like result. Treatment. — Where sympathetic ophthalmia has been once established, in all proba- bility irreparable damage will be done ; the great point to bear in mind is to prevent its occurrence by timely extirpation of the damaged glohe. (See " Extirpation of the Eye- ball.") Should the disease have become fairly establi.shed, little benefit can be expected to result from such extirpation, as the morbid changes will probably continue in the sym- pathetically inflamed globe in spite of the removal of that primarily aflfected. The sym- pathetically aff"ected eyeball (or. if excision have not been performed, both eyes) should be kept carefully bandaged with lint soaked in belladonna lotion ; all light should be carefully excluded by using a black bandage and keeping the patient in a darkened room. Pain must be relieved by the same methods as in cases of iritis. Any constitutional treatment that may appear necessary .should be employed, and as soon as the acute inflammatory symptoms have entirely subsided iridectomy should be performed. This operation often exerts a very beneficial influence upon the nutrition of the globe (see " Iridectomy "). and should be repeated a second, or even a third, time should the new pupil become (as is very likely to be the case) occluded by inflammatory exudations. Should suppurative inflammation be .set up in one eye, sympathetic changes need not be feared in the other : it is only in the adhesive form of choroido-iritis that sympathetic ophthalmia is likely to occur. Sympathetic Irritation. It not unfrequently happens that soon after the receipt of an injury to one eye its fellow becomes .slightly painful, intolerant of light, and irritable. These conditions may remain unchanged week after week and eventually sub.side. They make up what is known as " sympathetic irritation." (^LAlroMA. 283 Wlicii sympatlit'tic initaliim Dcciirs, we iiiiisi alwavs watdi tlic iMJiircd (>v<' ••aref'ullv ; and if sii^iis of clniroido-iiitis or ktTatitis puiiclata appt-ar in it, it should be ininicdiatidy excised. If no such symptoms occur, liowcvcr, its removal is not necessary. THE VITREOUS HUMOR. Opacities i" the vitreous are fretjuently met with in eases of niyoj»ia. and often as the rcsiihs of choroiditis. Inflammation <»f the vitreous occurs occasionally ; it is generally of syphilitic ori- gin or causcil liy injuries, especially the lodfjnient of foreijrn bodies within the globe. ^'ision becomes misty, and on examination the humor is found to l»c more or less turbid. Tkkat.m KNT. — Should the inflammation be of syphilitic origin, anti-syphilitic n-medies slnuild be emploved ; should it dejiend tin injury, the eye must be kept banrlaged with lint soaked in bclladoiiii;i lotion and nirasures taken to subdue the inflammation. Hemorrhage into the Vitreous. — Occasionally l)leeding takes place into the vitreous humor to a considerable extent. Impairment of vision is complained of, usually coming on suddeidy, and (jften during some exertion. Examination with the ophthalmo- scope (direct method) shows the vitreous chamber to be occupied by a turbid irregular cloud which floats about as the eyeball is moved, gradually subsides to its lower part when the movements are discontinued, and is stirred up again on the movement.s of the globe being repeated. The blood becomes absorbed to a greater or less extent in the course of time, but very commonly some permanent opacity is left. GLAUCOMA. By glaucoma we understand '• a series of morl)id changes of the eyeball ; the most prominent, and apparently the one which causes all the others, being an increa.se of ten- sion of the globe"' ( Bader). The cause of the increase of tension is unknown, but is supposed to result from undtie accumulation of the intraocular fluids, dependent on hyper-secretion or deficient removal. Glaucoma is said to be simph' when the increase of tension progresses slowly and continu- ously wMthout inflammatory outbreaks; acute or chronic when attended by attacks of inflammation. Simple glaucoma presents no very marked symptoms, its on.set being most insidi- ous. It is characterized by gradual decrease of acuteness of vision, with narrowing of the visual field, impairment of the power of accommodation, causing rather rapid increase of presbyopia, sluggishness in the movements of the iris, some dilatation of the pupil, and some apparent haziness of the lens. Increase of tension is probably one of the earliest symptoms, but is very liable to be overlooked until the disease is far advanced and con- siderable hardness of the globe has taken place. With the ophthalmoscope spontaneous pulsation of the retinal arteries may be seen, or pulsation may l)e produced by very slight pressure upon the globe. The ves.sels, especially the veins, are thinner on the surface of the optic disc than in the surrounding retina, and the disc itself may be more or less cupped. The cup of glauconui is characterized by a bluish appearance of the greater por- tion of the disc ; upon this blue portion the vessels appear very small and indistinct, or they may be quite invisible ; the margin of the disc is white, and the large tortuous reti- nal vessels are seen curling up over its edge and appearing on the surface of the retina at a point not continuous with their course upon the nerve surftice. Small hemorrhages may also be met with upon the retina. Absolute Glaucoma. — Sooner or later, in any form of glaucoma, if relief be not given, the condition known as ahsohifi- f/fduronid is established. The eyeball becomes stony hard, the pupil widely dilated and fixed, the cornea hazy and anaesthetic, the iris and acjueous humor discolored, the anterior chaml»er shallow, and the lens more or less opaque. A few dilated veins are seen issuing from the globe in the ciliary region ; the sclerotic may be somewhat bulged in places and bluish in color, and the conjunctiva is extremely rotten, tearing on any attemjit to seize it with forceps. On examination with the ophthalmoscope, all appears dark behind the pupil or a dull-red reflection may be returned from the interior, but no details of the fundus can be made out. All perception of light is lost. In some cases of acute glaucoma, and almo.st invariably in chronic glaucoma, the onset of the disease is preceded by premonitory symptoms. 284 GLA UCOMA. These are, as in simple glaucoma, rapidly-increasing presbyopia and slight increase of tension of the globe, sluggishness and dilatation of the pupil, some apparent haziness of the lens, and narrowing of the visual field. Besides these, we may find some congestion of the veins emerging from the sclerotic in the ciliary region. There may be periodic attacks of dimness of vision, objects appear- ing as if veiled by a grayish or yellow mist (London fog) ; in the later stages we may have a halo around a flame or the appearance of a rainbow, and at times attacks of pain in and about the eyeball. Acute glaucoma usually commences suddenly with well-marked inflammatory symptoms. The ]»atient will state that he was seized (frequently during the night) with sudden severe pain in the eye ; the pain will be described as affecting not only the eye- ball, but the whole of the corresponding side of the head, and he will have found that the sight of the painful eye is much impaired or entirely lost. On examination, the eye- lids will be found slightly reddened and swollen, the conjunctiva somewhat chemosed, and its vessels, as well as those situated more deeply in the subconjunctival tissue, enlarged. There will be profuse lachrymation, and often much intolerance of light; the aqueous humor will very probably be somewhat turbid. The pupil will be moderately dilated, somewhat irregular and fixed, and the tension of the globe greatly increased. On examination with the ophthalmoscope, some of the appearances mentioned under " Simple Glaucoma " may be found, but the media will probably be so hazy as to ob.*cure the parts behind, a dull-red reflection being all that can be made out. The acute symptoms may pass off in the course of a few days or weeks, leaving the eye more or less permanently damaged. Similar attacks may recur, but more frequently the disease relapses into a chronic state. Chronic glaucoma, the form most commonly met with, is characterized by the occurrence of slight inflammatory attacks associated with temporary increase of dimness of vision and more or less pain in and around the eyeball. On examination, the field of vision will be found to be limited, the tension of the globe increased ; and if the patient present himself during an inflammatory attack, the conjunctiva and subconjunctival tissue will be found unduly vascular, the pupil somewhat dilated, and the movements of the iris sluggish. The loss of vision in cases of chronic glaucoma is attended by symptoms like those of the premonitory stage. Patients complain that their sight is always somewhat misty, that there is an appearance of a bright halo around a candle or other flame, that they .see colors resembling a rainbow and often of great beauty, and occasionally flashes of light and fiery circles ; the last-mentioned symptoms are, however, common to all forms of retinal irritation. Vision is always worst during the inflammatory attacks and recovers to a certain extent during the remission, never, however, returning to the same condition as before the attack. The ophthalmoscope shows changes similar to those mentioned under '• Simple Glaucoma." Glaucoma Fulminans. — There is yet another form of glaucoma requiring men- tion — fortunately, rarely met with. Its principal characteristic is the extreme suddenness and violence of its onset ; its symptoms resemble those of acute glaucoma in an aggra- vated form. This variety of glaucoma is known as glavcoma fidminans^ and the eye attacked by it may be entirely lost in the course of a few hours. The attack is occasion- ally accompanied by severe headache and vomiting. Glaucoma is essentially a disease of the latter half of life, occurring mo.st frequently between the ages of forty and sixty, but occasionally in young adults, or even in chil- dren. Glaucoma almost always affects both eyes — not, however, simultaneously, but at more or less considerable intervals. Diagnosis. — In order to diagno,se glaucoma we must be well acquainted with the method of ascertaining the tension of the globe, and also with the use of the ophthal- moscope. (See " I^xamination of Eyeball," etc.) We must also remember that the injurious effects of pressure are evidenced earliest in the peripheral portions of the retina, and should therefore very carefully examine the condition of the visual Jiehl in all suspected cases. (See " Examination of Field of Vision.") Cases are frequently met with in which great contraction of the visual field has taken place, although central vision is still acute. Another symptom which should lead us to suspect glaucoma is the rajnd increase of presbyopia. Patients affected by the simple or Tin: iniTlSA AM) (JJ'TJC MlllVI-:. 2Ho pliroiiic tonus ;/ 'ijitra/ioii iilnui'. Anil it is our iliity to explain to the patient the nature of his case ami to ur