W^tfnmn ICtbrarg 1583 Digitized by tine Internet Arciiive in 2010 witii funding from Open Knowledge Commons http://www.archive.org/details/mortalityfromcanOOhoff THE MORTALITY FROM CANCER THROUGHOUT THE WORLD FREDERICK L. HOFFMAN, LL.D., F.S.S., F.A.S.A. Statistician The Prudential Insurance Company of America; Chairman Com- mittee on Statistics, American Society for the Control of Cancer; Member American Association for Cancer Research; Associate Fellow American Medical Association; Associate Member American Academy of Medicine, etc., etc. Newark, New Jersey THE PRUDENTIAL PRESS 1915 (riven by Fjitlixh^r. MAY I 5 M« Copyright, 1916 By THE PRUDENTIAL INSURANCE COMPANY OF AMERICA Newark, New Jebset ■RCt-GI Copu TO The American Society for the Control of Cancer AND The American Association for Cancer Research FREDERICK L. HOFFMAN jHE PRUDENTIAL INSURANCE COMPANY STATISTICIAN OF AMERICA HOME OFFICE, NEWARK. NEW JERSEY May 10, 1915. Mr. Forrest F. Dryden, President. Dear Mr. Dryden: Nearly two years ago an invitation was extended to me by the president of the New Jersey Academy of Medicine, Dr. Edward J. Ill, of Newark, to address that society on some subject of my own selection. After careful consideration I agreed upon a discussion of "The Menace of Cancer," as in the light of our own experience perhaps the most important medical problem demanding special attention along lines of public and individual control. This subject had for some years past been given more or less consideration as one of increasing significance in life insurance medicine, best emphasized in the statement that at ages forty- five and over, in our Ordinary experience of 1914, 9.6 per cent, of the deaths of males and 18.6 per cent, of the deaths of females were the result of malignant disease. The address was delivered on March 26, 1913, and subsequently, upon the urgent invitation of the American Gynecological Society, was, with many additions and new illustrations, brought before that im- portant body, at a meeting held in Washington on May 7, 1913. Some time previous, however, steps had been taken to develop an organized effort for a nation-wide educational cancer movement, and accordingly, on May 22, 1913, the American Society for the Con- trol of Cancer was formed. This association has since become an in- fluential body, aiming primarily at the widest possible dissemination of the salient facts of the cancer problem and the clear recognition on the part of the public of the supreme importance of the earliest possible diagnosis and the qualified treatment of the disease in its initial stage. The public aspects of the cancer question are best emphasized in the statement that the mortality from cancer in the Continental United States now exceeds 80,000 per annum, and that the rate of mortality from this disease is increasing approximately 2.5 per cent, per annum. A considerable proportion of the mortality is, in part at least, directly attributable to public ignorance and neglect of known measures and means by which the mortality can be materially reduced. In the organization of the American Society for the Control of Cancer I was honored with the position of Chairman of the Committee on Sta- tistics. The additional members of this Committee are Dr. James Ewing of the Cornell Medical School, New York City, and Dr. Joseph C. Bloodgood of The Johns Hopkins Hospital, Baltimore. The Committee has given extended consideration to many important statistical ques- tions; but it was early realized that the efforts of the Society would be materially advanced by a concise presentation of the statistical evidence regarding cancer frequency throughout the United States and the re- mainder of the civilized world. The need of trustworthy statistical information was especially realized in connection with the work of local committees and the nation-wide effort to place the salient facts of the existing cancer situation before the public in a readily comprehended form. In aid of this educational propaganda I have had occasion to address many such meetings throughout the country, and naturally in each and every case my own observations and conclusions were chiefly sustained by an appeal to the actual facts of cancer occurrence in the locality or sections in which the meetings were held. A large amount of exceptionally useful statistical information was thus brought together, and since the material would unquestionably be of great practical value, not only to those directly interested in cancer education, but also to the medical profession generally and to specialists engaged in cancer research, it seemed but a pubhc duty on our part to make the data more generally accessible to the public at large. The suggestion was therefore brought to your attention, and you were good enough to approve of my recommendation that a work of this character should be published by The Prudential, as perhaps the most substantial aid to be rendered by the Company in the furtherance of the cause of cancer control. The broadening of the plan and scope of the original inquiry has expanded the work into one of considerable size, but the general usefulness of the results has thereby been proportionately in- creased. The entire matter is now resubmitted to you for your final approval, with the suggestion that the work be dedicated to the American Society for the Control of Cancer and the American Association for Cancer Research. It is further recommended that the work be made available for gratuitous distribution, with the compliments of The Prudential, to medical libraries, members of the medical and surgical professions, and to all others especially interested in the cancer cause and the problem of cancer control. In conclusion, I make use of this opportunity to express to you my sincere personal appreciation of the broad-minded position which The Prudential has taken in this as well as many other questions relating to the activities of health-promoting agencies. In the furtherance of nation-wide efforts to reduce mortality and to prolong the duration of human life we have frequently been able to render scientific assistance of practical and permanent value. I feel sure, however, that whatever we may have done in the past, especially as regards our cooperation in the campaign against tuberculosis; in the prevention of industrial accidents; and in the gradual reduction of the mortality from acute infectious diseases of infancy, etc., the service which the present publi- cation will render in the world-wide quest for the whole truth of the cancer problem and the effective control of malignant disease is certain to prove the most substantial of all. I remain very truly yours. Approved : Statistician. / President. PREFACE The practical importance of cancer to life insurance companies is precisely shown in the statement that out of 5,529 deaths from all causes in the Ordinary experience of The Prudential during 1914, 416 deaths, or 7.5 per cent., were from malignant disease, or 6.4 per cent, of the mortality of males and 12.0 per cent, of the mortality of females. Limited to ages forty-five and over, the Ordinary experience of the Company for the year 1914 shows that of the deaths of males 9.6 per cent, were from cancer, against 18.6 per cent, of the mortality of females. Cancer was the third most important cause of death among males at ages forty-five and over, and the leading cause of death in the corre- sponding mortality of insured women. The exceptional importance, therefore, of the cancer problem to life insurance companies will not be called into question by any one familiar with the general facts of the cancer situation and aware of the lamentable truth that there are now annually over 80,000 deaths from malignant disease in the Continental United States and that the disease is increasing at the approximate rate of 2.5 per cent, per annum. If the present rate of increase continues un- checked, the annual cancer mortality in the Continental United States will soon exceed 100,000 ! The present work is primarily intended to facilitate the statistical study of the cancer problem throughout the world. On account of the exceptional facilities for statistical inquiry available through the library of The Prudential and the hearty cooperation of oflScials of the Federal Government, the several states and many foreign countries, a large amount of entirely new information is made conveniently accessible to the student of the cancer problem, to the medical profession and to the general public. The main results of the investigation may be summed up in the brief but extremely suggestive statement that the actual frequency of malignant disease throughout the civilized world has been ascertained to be much more of a menace to the ivelfare of mankind than has generally been assumed to be the case, and thai in contrast to a marked decline in the general death rate, cancer remains one of the few diseases actually and 'persistently on the increase in practically all of the countries and large cities for which trustworthy data are obtainable. In a work of this kind minor errors are, naturally, not entirely avoid- able, but a special effort has been made to reduce the chances of clerical mistakes to a minimum by several thorough and independent revisions of the numerous statistical tables appended to the text. Wherever practicable the source of the information used is indicated, and full credit has been given to authors quoted or consulted, aside from a fairly complete bibliography, limited to works actually made use of, nearly all of which are in the library of The Prudential. It would be quite impos- sible to make mention by name of all the many correspondents through- out the world, government officials, officers of life insurance companies, and others, who have most courteously and considerately rendered PREFACE valuable aid and without whose aid the results of this investigation would have been materially diminished in practical utility. Among those, however, who have rendered exceptionally useful personal assis- tance, mention should be made of Lieutenant-Colonel C. E. McCul- loch, Jr., Librarian of the Surgeon-General's Library, Dr. Cressy L. Wilbur, former Chief Statistician for Vital Statistics of the United States Census, and Mr. R. C. Lappin, the acting chief of that office, Dr. Joseph C. Bloodgood, Dr. Thomas S. CuUen, Dr. James Ewing, Dr. H, R. Gaylord, Dr. Edward J. Ill, Dr. William L. Rodman, Dr. Harry M. Sherman, Dr. J. H. Wainwright, Dr. Francis Carter Wood and Dr. W. A. Jaquith, Medical Director of The Prudential. All of the statistical tabulations and supplementary calculations have been made in our office under my immediate direction and supervision; but efficient and valuable assistance has been rendered by Mr. Frederick S. Crum, Ph. D., Assistant Statistician of The Prudential, who has carefully revised the entire proof, and provided a complete index, by authors and subjects. Among the clerks deserving of mention are IMr. Roy F. Ed- wards, who has revised and corrected the statistical tables for the United States and its subdivisions, Mr. Knud Stoumann, wlio has had entire charge of the foreign tables, Mr. Thomas J. Garvey, who has made the final general revision of rates and ratios, and Mr. Edwin E. A. Fisher, who has drawn the twenty-one charts illustrating the salient facts of the cancer problem. The bibliography is largely the work of Miss Adelaide S. Rinck. The printing of the work by the Prudential Press has involved many technical problems and an unusual demand for painstaking attention to minute details in the corrections and final proofreading of the text and tables. These difficulties were successfully overcome through the efficient assistance and hearty cooperation of Messrs. J. W. McLaughlin, C. E. Lund and J. J. Macbride, of our Printing Department. The artistic design of the charts is the work of INIr. Edwin S. Fancher. The work is divided into nine chapters, to all but one of which there is an appendix of forms or tables, which, as a matter of convenience, have been placed together at the end of the volume. Chapter I, on The Statistical Method in Medicine, is amplified by an appendix of the principal cancer classifications, past and present, used in standard text- books and in the compilation of international cancer mortality statistics. This appendix also includes a useful classification of accessible, inaccessi- ble and intermediate malignant tumors, as recommended by the Im- perial Cancer Research Fund. Chapter II, on The Statistical Basis of Cancer Research, is a brief discussion of the fundamental statistical facts available for analysis, enlarged by an appendix of the blanks and certifi- cates used in connection with cancer mortality investigations and special research, including the question form for cancer census purposes recom- mended by the International Association and the special blanks for supplementary inquiries into the facts and circumstances connected with the occurrence of cancer of the uterus, mammary cancer, gastric cancer and cancer of the buccal cavity, adopted and recommended by the Statis- tical Committee of the American Society for the Control of Cancer, in cooperation with the General jNIemorial Hospital of the City of New PREFACE York. Chapter III, on The Increase in Cancer, is an extended discus- sion of the general problem of the observed upward tendency of the can- cer death rate throughout the world. The required statistical evidence in support of the conclusion that cancer is actually and not only appar- ently on the increase is, however, included in the appendices to the several chapters on the geographical incidence of cancer in the United States and foreign countries. The Mortality from Cancer in Different Occupations is discussed in Chapter IV, with an appendix of eight tables of the mortality from cancer in selected industries and employ- ments, derived from the decennial reports of the Registrar-General of England and Wales, but rearranged and recalculated for the present purpose. In addition, the appendix includes cancer mortality data by occupations, derived from the Industrial mortality experience of The Prudential and the cancer census of Hungary. Chapter V presents an extended discussion of Cancer as a Problem in Life Insurance Medicine, historically and practically considered, with an appendix of 121 tables, including a concise and uniform presentation of the general cancer experience data of a large number of American and foreign life insurance companies and the collective results of the Medico- Actuarial Mortality Investigation. Chapter VI, on The Geographical Incidence of Cancer Throughout the World, brings out forcibly the wide range in the cancer frequency rates of different countries and cities with widely varying circumstances of race, climate, habits, etc., all of which are shown to have an important bearing upon the cancer problem as a whole. Included in this chapter are the results of a special analysis of the data collected by the New York State Institute for the Study of Malignant Disease concerning the primary seat of growth, probable cause, the personal and family history, etc. The information is made available for the first time through the courtesy of the Director of the Institute, who placed the original material at our disposition for tabula- tion and analysis. The principal tables of the appendix to this chapter show the facts of cancer mortality according to latitude, size of cities and the local rates of incidence by organs and parts of the body for thirteen representative countries throughout the world. In Chapter VII, on The Statistical Data of Cancer Frequency in American States and Cities, the rate of cancer occurrence throughout the United States is discussed at some length, and amplified by an appendix of 259 tables of cancer mortality for the registration area and for the several states and cities in a uniform manner and with a due regard, as far as practicable, to the elements of age, sex, race, organs and parts, etc. Chapter VIII presents the corresponding information on The Statistical Data of Cancer Frequency in Foreign Countries, with an appendix of 389 tables for countries other than the United States, Chapter IX concludes the results of the statistical inquiry with Some General Observations and Conclusions on the Cancer Problem. This is a general discussion of practically all the more or less controversial aspects of the cancer question, with a first regard, however, to sociological, anthropological and general scientific consideration. The observations are included as a matter of convenience to aid those who wish to make practical use of the statistical information, and they are not to be PREFACE construed as a final expression of qualified medical opinion regarding any or all of the controversial aspects of the world-wide quest for the whole truth of the cancer problem. The appendix to this chapter includes reprints of suggestive educational circulars used in connection with the nation-wide propaganda for cancer control under the auspices of the American Society for the Control of Cancer, etc. The cancer question is as old as the history of medicine, and the literature of oncology in all its branches is enormous. Regardless, how- ever, of all that has been written and said upon the subject, there can never come a time when the field of statistical inquiry will be exhausted. Verifiable progress in the direction of health and longevity requires the use of the statistical method, impartially applied to the subject under consideration. Cancer is apparently the most involved and practically difficult problem in the entire science and art of medicine and surgery. An army of men of the highest order of intelligence have been at work for many years in quest of the cancer cause and a cancer cure. Statistics, it is true, is but an auxiliary science, but it is one of great promise in the furtherance of medical research; for, after all, the study of collective phenomena, regardless of innumerable possibilities of error or false conclusions, provides the only trustworthy means of determining with approximate accuracy the existing amount of disease and the apparent tendency towards improvement or deterioration, as the case may be. It is readily to be conceded that the data are often faulty or incomplete, but this is not a fatal objection. The betterment of our vital statistics requires the cooperation of the medical profession, life insurance com- panies, public health officials and all others directly or indirectly interested in the prolongation of life and the prevention of disease. In proportion as the practical utility of vital statistics is better understood and more generally appreciated, the required perfection of fundamental mortality data will be brought nearer to the attainable ideal. The results of the present investigation emphatically prove the im- perative need of uniformity in the rules of statistical practice and the adoption of standard forms and blanks for cancer inquiries. The main shortcomings of the investigation are attributable to the want of uni- formity in methods of classification and the more or less abbreviated presentation of the original facts provided by the death certificate. It is sincerely to be hoped that the results, inadequate as they are, will suggest the necessity for an international agreement regarding general con- formity to the best methods at present in use. Such an improvement can be brought about only by the cooperation of all who are directly and im- partially interested in cancer study and cancer research. Until the ideal is attained and uniform methods of classification and completeness of records are secured for all the countries of the civilized world, the present work will at least serve the purpose of having made the existing statistical facts of cancer frequency available in a convenient form. In its final analysis, the essential requirement is not the absolute truth, but the approximate or relative truth. For all practical purposes the latter is fully sufficient, and serves as a safe and satisfactory guide in all the ordinary affairs of life. Conceding frankly the inherent defects and shortcomings of existing statistical data and present-day methods of PREFACE statistical tabulation and analysis, it would seem to be an entirely safe assumption that, in the main, the general conclusions based upon the available statistics of human mortality throughout the world are ap- proximately correct and trustworthy in the advancement of the aims and ideals of a world-wide associate effort at the prolongation of life and the prevention of disease. It is therefore to be hoped that the present work may render substantial assistance toward the attainment of this purpose, that it may lighten the labor of those in need of statistical data re- quired in other lines of specialized cancer research, that it may emphasize concretely and conclusively the truly tremendous social and economic importance of malignant disease as a cause of death in adult life, and that it may accelerate the effort to disseminate the whole truth regarding this insidious afHiction among the general public and emphasize the supreme necessity for early diagnosis and early qualified medical or surgical treatment. If the investigation contributes measurably towards the realization of these aims and ideals, the results, though at first quite general in their nature, must ultimately react favorably upon the vast business of life insurance companies, which are primarily and preemi- nently interested, on behalf of their policyholders, in any and all measures aiming at the deliberate prevention and control of disease and the highest attainable average duration of human life. F. L. H. Newark, N. J., May 2, 1915. TABLE OF CONTENTS Chapter I page The Statistical Method in Medicine 1 Sources of Statistics — Principles of Analysis — Terminology — Difficulties of Diagnosis — Early History — Past and Present Methods of Classification — Natural History of Cancer — Standardized Death Rates — Function of Age and Senility — Ethnic Factors — Question of Cancer Increase — Death Certification and Classification. Chapter II The Statistical Basis of Cancer Research 21 Limitations of Statistical Analysis — Difficulties of Precise Classification — Early Observations on Cancer Statistics — Need of an Exhaustive Study — Uniform Methods of Tabulation and Analysis — ^Recognition of Cancer — Lnportance of Microscopical Research. Chapter III The Increase in Cancer 28 Early Mortality from Cancer in London — Causes of Local Variations — Argu- ment by King and Newsholme — Statistics of Frankfurt a/M. — Increase in Cancer by Organs and Parts — Utility of a Cancer Census — Cancer among Primitive Races — Statistical Problems of Erroneous Diagnosis — Evidence of Cancer Increase throughout the World — Misleading Statistical Observations — Useless Controversies — Trustworthiness of American MortaHty Statistics — Contributory Causes of Death in Cancer — Continued Increase ia Cancer Frequency — Pubhc Menace of Ignorance and Indifference, Chapter IV Mortality from Cancer in Different Occupations 48 Review of the Literature on Cancer in Relation to Occupation — Cancer in the Patent-fuel Industry — Pitch Ulceration and Paraffin Cancer — Occupational Incidence — Alcoholism — Prisons and Asylums — Petroleum Industry — Malig- nant Disease of the Lungs in JVIiners — Gardening and Agriculture — Cancer among Paraffin-workers — Brewers — Furriers and Skinners — Seamen — Tia- plate-workers — Lead-workers — Rubber-workers — Chemical-workers — X-ray Workers — Cancer and Exposure to Light — Cancer in the Synthetic-dye Industry — Occupational MortaHty Statistics — Life Insurance Experience — Foreign Statistical Investigations — Requirements of Scientific Statistical Research. Chapter V Cancer as a Problem in Life Insurance Medicine 77 Cancer in the Literature of Life Insurance Medicine — Early Life Insurance Experience Data — Discussion of Scottish Widows' Fund Experience — Observations Regarding Cancer Increase — ^Experience of American Life Insur- CONTENTS PAGE ance Companies — German and Austrian Insurance Experience — Medico- Actuarial Investigation — Family History — Effect of Build and Conjugal Con- dition — Cancer of Breast and Generative Organs among Single and Married Women — Experience of The Prudential Insurance Company of America — Cancer as a Life Insurance Problem. Chapter VI The Geographical Incidence of Cancer Throughout the World .... 104 Problems of Geographical Pathologj' — Recent International Statistics — Cancer Frequency throughout the World — Distribution of Cancer in the United States — Local Variations in Cancer Occurrence — Mortality from Biliary Calculi and Tumors of the Uterus and Ovaries — Increase in Cancer, by Organs and Parts, and by Age and Sex — -MortaUty by Season — Statistics of the New York State Pathological Institute — Pre\'ious Duration of Malignant Disease — Family History and Heredity — Primary Seat of Growth, Probable Causes, and Personal Historj' — Geographical Pathology of Cancer by Specified Organs and Parts, throughout the World. Chapter VII The Statistical Data of Cancer Frequency in American States and Cities 126 Limitations of Crude Statistics — Progressive Increase in the Cancer Death Rate — Mortality in Large American Cities — Sources of Errors — Range in Cancer Death Rates — Comparative Mortality Rates by Organs and Parts — Comparative Mortality Rates by Age, Sex and Race — Cancer among Mexicans. Chapter VIII The Statistical Data of Cancer Frequency in Foreign Countries . . 133 Comparative Cancer Mortality Rates for Europe — Africa — Asia — Australasia — Western Hemisphere — Limitations of International Statistics — Cancer a World-\N-ide Menace — Effect of Latitude and Longitude, and of Size of Cities — Comparative Death Rates of American and European Cities. Chapter IX Some General Observations and Conclusions on the Cancer Problem 146 Cancer among Primitive Races — Cancer among the Jews — North American Indians — Gypsies — Determinable Factors of Cancer Frequency — Age and SeniHty — Physical Condition — Growth and Development — Precancerous Lesions — Gastric Ulcers and Gall-stones — Uterine Cancer — Early Diagnosis — Hospital Statistics — PubUc Institutions — Soldiers' Homes — Surgical Aspects — Problem of Recurrence — Duration of Disease — Degree of Ma- lignancj — Clinical Signs — Anaemia — Prognosis — Heredity — Overnutrition — Metabolic Disorders — Vegetarianism — Diet — Civilization — Theory of Atra Bills — Biochemical Aspects — Goitre — Thyroid Carcinoma — Obesity — Alcohol — Smoking — Gall-stones and Chronic Irritation — Tuberculosis — Sj^jhilis — Rheumatism — Gout — Diabetes — Appendicitis — Parasitic Theory — Cancer Houses and Villages — Cancer a Deux or Marital Infection — Surgical Infection — Worry — Insanity — Need of Educational Campaign in Methods of Control — Restatement of Conclusions and Results. CONTENTS L/HARTS PAGE 1 International Statistics of Cancer Mortality, 1908-1912 224 2 Comparative Cancer Mortality in American and Foreign Cities 22G 3 International Cancer Mortality by Organs and Parts 228 4 Cancer Mortality by Age and Organs or Parts, 1903-1912, United States Registration Area 230 5 Cancer Mortality by Sex and Age, 1901 and 1911, United States Registration States of 1900 232 6 Comparative Cancer Mortality of Southern Cities, by Race . . . 234 7 Cancer Mortality of Maryland, by Race 236 8 " " United States Registration Area 238 9 " " England and Wales 240 10 " " Ireland 242 11 " " Holland 244 12 " " Bavaria 246 13 " " Switzerland 248 14 " " Italy 250 15 " " Japan 252 16 " " Australia 254 17 " " Uruguay 256 18 " " New York City 258 19 " " London 260 20 " " Prudential Industrial Experience 262 21 Cancer Fatality Rate, The Johns Hopkins Hospital 264 Appendices A Tumor Classifications 267 B Cancer Records, Inquiry Blanks and Forms 284 C Mortality from Cancer in Different Occupations 305 D Cancer Mortality Statistics of Life Insurance Companies 316 E International Cancer Mortality by Latitude, Size of Cities and Specified Organs and Parts 402 F Part I — Cancer Statistics of the United States Reg. Area. . . . 418 Part II — Cancer Statistics, States and Cities of United States . . 450 G Cancer Statistics of Foreign Countries 582 H Recommendations and Instructions on the Control of Cancer 776 Bibliography 787 Index of Authors 807 Index of Subjects 811 A STATISTICAL SURVEY OF THE MORTALITY FROM CANCER THROUGHOUT THE WORLD CHAPTER I THE STATISTICAL METHOD IN MEDICINE Sources of Statistics — ^Principles of Analysis — Terminology — ^Difficulties of Diagnosis — Early History — Past and Present Methods of Classification — Natural History of Can- cer — Standardized Death Rates — ^Function of Age and SeniHty — Ethnic Factors — Question of Cancer Increase — Death Certification and Classification. Within the vast range of collective phenomena there are few more in- teresting subjects for statistical analysis than cancer, or what is, perhaps, more appropriately termed the science of ojicology, which comprehends tumors of all kinds, whether malignant or benign or ill-defined. The mortality from tumors has at all times attracted considerable attention, and even some of the earliest contributions to the scientific study of cancer include statistical observations derived from general mortality or hospital records. If the mortahty from cancer were a constant quantity, it would be a foregone conclusion that the ascertainment of the underlying causes or conditioning circumstances of cancer frequency would defy analysis. Since the cancer death rate throughout the world is subject to a very considerable variation, it is equally obvious that the underlying causes or conditioning circumstances must vary to an equal degree, and therefore come within the range at first of scientific conjecture and at last of scientific conclusiveness. It is for these reasons that the statistical method in medicine has been of such exceptionally practical value when applied with skill and impartiality to the study of questions unusually involved because of the innumerable factors u'nderlying observed phenomena more or less indefinitely termed disease and death. Statistics is chiefly an auxiliary method in connection with scientific inquiries; but it is none the less necessary to caution the inexperienced against the use of a method or science which on its own account requires as much study and consideration, and as much practical experience, as medicine or surgery or both com- bined. The liability to error in the correct interpretation of collective phenomena subjected to critical analysis is fully as great as the chances of mistakes in medical or surgical diagnosis. The practical value of the statistical method in medicine, however, is now fully recognized by the foremost authorities on medicine, surgery, biology and public health and the method has the sanction of many years of extensive teaching experience. The use of statistical data in the consideration of medical and sanitary problems has therefore become practically in- dispensable. The broadening sphere of medicine, which now includes a vast system of public health administration and the medical education of the general public in matters of personal hygiene, more than ever suggests the importance of extreme care and caution in the use of the statistical method, which alone, however, provides the means of arriving THE MORTALITY FROM CANCER at approximately accurate conclusions regarding the relative degree of frequency of different diseases and the apparent tendency of particular diseases to increase or diminish, in proportion to the population afifected. Difficulties of Statistical Research The statistical study of cancer involves exceptionally difficult technical considerations, which arise largely out of the complex nature of the cancer problem, biologically, pathologically, medically or surgically considered. The literature of cancer statistics is quite considerable, but largely con- troversial, and much of it is decidedly superficial and misleading. Statistical fallacies in cancer discussions are so common that the required statistical treatment of the subject has been much impaired in value, with a world-wide loss of confidence in the results. Progress, however, is being made in the direction of a more rational and trustworthy treatment of cancer facts and in the necessarily concise presentation of the data with at least an approach to uniformity, based on standardized methods of original inquiry. The statistical material of cancer mortality for the civilized countries of the world is, however, so enormous that a complete analysis of all the facts is quite impossible. The gradually expanding registration area of the world provides an increasing amount of statis- tical material, and more qualified consideration is being given to the elementary conditioning factors, such as age, sex, race, etc. For many countries no information regarding the incidence of cancer by organs or parts of the body affected is as yet available; but this defect is also gradually being corrected. The inherent hmitations of all can- cer mortality data are being better appreciated on the part of the medical profession, government officials and the general pubHc, so that the increasing volume of statistical information is also improving in quality and is therefore becoming more useful in the world-wide quest for the whole truth of the cancer problem. Sources of Cancer Mortality Statistics All cancer mortality statistics for the general population are derived from official mortality records or death certificates originally filled out by the attending physician or some person assumed to be familiar with the facts as regards the cause of death.* In the absence of compulsory medical attendance it is obvious that such records must vary in accord- ance with the perfection of death certification, and it is self-evident that the returns for countries in which a medical certificate as regards the cause of death is not required must be of very limited intrinsic value. For most of the civilized countries this requirement is met to a reason- ably satisfactory degree, and what has been said by Longstaff with reference to the value of death certification in England appHes to most of the other large civilized countries for which the cancer mortality data are available for a period of years. In his "Studies in Statistics," in connection with a critical study of the national system of vital statistics, George B. Longstaff observes I am thoroughly convinced of the soundness of that system and the fallacies inherent in all attacks upon it. Moreover, having studied for several years the figures relating to "Alleged Causes of Death," I have been more and more convinced of the value of those •The sources of cancer mortality statistics are fully discussed in Chapter II. STATISTICAL METHOD IN MEDICINE figures, and I fully believe that they may be taken as, on the whole, a fair approximation to the truth. At the same time it is hardly necessary to say that, like all other statistics, they require care and knowledge in handling. Without doubt the figures relating to alcoholism, venereal diseases, and perhaps insanity, are almost valueless; but that does not prove that those relating to scarlet fever, pneumonia, or cancer are equally valueless. Neither does the fact that a large number of certificates are carelessly filled up invalidate the far larger number that are more trustworthy: indeed, these very sources of error are subject to laws, and are more or less constant factors of the whole. When it is possible, as I have elsewhere proved it to be, to find general laws regulating many of the causes of death, and especially mutual relations between these causes, and relations between some of them and various external phenomena, the only possible inference that I can deduce is that the figures dealt with are the expression, more or less accurate, of facts in nature. This conclusion does not in the least minimize the serious risk of error in the careless or superficial use of the data of mortality statistics, irrespective of the diseases dealt with ; for, as pointed out by Longstajff on the same occasion, "there are numerous fallacies to which the classifi- cation of deaths according to their alleged causes is liable." And he enumerates particularly the more or less varying proportions of ill- defined deaths, the more or less varying proportions of indefinite causes, the deliberate falsification of returns for personal or family reasons,* and the effect of the progress of medical science, improved diagnosis, etc. All of these reasons notwithstanding, the conclusion appears to be in- controvertible that on the whole the present system of death registration is entitled to confidence and that the results approximately represent the true state of the nation's health. f Fundamental Principles of Statistical Analysis The fundamental principle of all statistical inquiries is the law of large numbers. The accuracy of the statistical judgment is in propor- tion to the mass of the material considered and the thoroughness of the methods of analysis in matters of detail. The law of large numbers is defined in the statement that "in a large number the actual relations are more accurately expressed than in a small number," and hence the probability may be concluded much more safely from a large number of observations. The exceptional cases are obliterated in the large number, which approaches more closely to the truth, and as such re- quires to be accepted as approximately conclusive. In conformity to this principle the statistical investigation of cancer should be on as broad a scale as possible, with a due regard, of course, to the quality of the facts as well as to their quantity. For reasons which do not require discussion, the application of mathematical methods to the cancer problem is decidedly less desirable than the use of impar- tially collected statistical data derived from a large area of observa- tions, extensive in point of time. J •This aspect of the cancer problem is of considerable practical importance. I have briefly discussed the subject in an address on "The Accuracy of American Cancer Mortality Statistics," read before the American Public Health Association, Jacksonville, 1914. tSee also in this connection the correspondence between Dr. Bashford and myself in the London Lancet, Feb- ruary 7 and April 11, 1914. JThe principal works of reference in support of this point of view are "Letters on the Theory of Prob- abilities," N. A. Quetelet, London, 1849; "Essays and Papers on Some Fallacies of Statistics concerning Life and Death, Health and Disease," Henry W. Rumsey, London, 1875; "History, Theory and Technique of Statistics," August Meitzen, Philadelphia, 1891; "Studies in Statistics," Geo. B. Longstaff, London, 1891; and "Essay on Collective Phenomena and the Scientific Value of Statistical Data," E. G. F. Gryzanovski, American Economic Association, 1906. Important references to errors and defects in vital statistics 3 THE MORTALITY FROM CANCER Difficulties of Cancer Terminology Since the term "cancer" does not permit of an absolutely scientific definition, it is obvious that the statistical consideration of the data derived from different, though official, sources can not be made to con- form to the most rigid demands of scientific accuracy. The borderland of innocency or malignancy in tumors is large or small according to the skill and experience of the diagnostician.* The accuracy of the diagnosis itself is affected by the seat of the disease and the necessary oppor- tunities for autopsies and subsequent microscopical research. A scien- tific definition of the term "tumor" is by all competent authorities admitted to be at present impossible. But it is now less difficult than in former years to exclude small swellings of numerous kinds which can not properly be regarded as within the tumor class. Cancer is unquestion- ably a fundamental disorder of postnatal growth and development. It has properly been observed by Rudolph Schmidt in his treatise on "Diagnosis of Malignant Tumors of the Abdominal Viscera"t that "in their ultimate causes all processes of growth are traced back to and become merged with the problem of life itself." Regardless of a truly enormous literature, the origin, life history and causation of tumors remain obscure; and until further progress is made in this direction the terminology of oncology must remain unsatisfactory. In their work on "General Pathology," Pembrey and Ritchie say that "in the case of true tumors the characteristics to be looked on as com- mon to all are, first, that there is a progressive proliferation of cells; and, secondly, that such proliferation does not occur in response to any normal requirement of the tissue from which the tumor springs. "{ The characteristics of malignant tumors, with which the present dis- cussion is almost exclusively concerned, although some attention will be given to tumors of the non-malignant type, are briefly defined by these authors as First, generally speaking, their growth is much more rapid, and, secondly, in addition to the original focus, secondary foci tend to appear in other parts of the body. In addition to this, a third outstanding feature of the malignant tumor is the fact that at the periph- eral parts there is almost invariably an infiltration of the surrounding parts with ex- tensive, fine, frequently microscopic prolongations, which make it impossible to mark off by any palpable characteristic the growth from the tissues in which it lies.^ *"It has long been held that some benign growths are peculiarly liable to undergo transformation into cancer. This view is held, among others, by Sir James Paget, Sir Jonathan Hutchinson, and Dr. Max Borst. The innocent tumors which are regarded as most likely to undergo this change are sebaceous adenomata, moles, warts, and adenomata in general, but no innocent tumor seems to be more likely to undergo cancer degeneration than the multiple polypoid adenoma of the rectum." ("The Disorders of Post-Natal Growth and Develop- ment," Hastings Gilford, London, 1911.) t"Diagn»si3 of the Malignant Tumors of the Abdominal Viscera," by Rudolph Schmidt; English trans- lation by Joseph Burke, New York, 1913. t "Text-book of General Pathology," edited by Pembrey and Ritchie, London, New York, 1913, p. 224. g "Text-book of General Pathology," edited by Pembrey and Ritchie, London, New York, 1913, p. 227. are the following: "A Study of Three Thousand Autopsies," Richard C. Cabot, Journal of the American Med- ical Association, December 28, 1912; "Past and Present of the Autopsy in Medical Education and Practice," H. Oertel, Journal of the American Medical Association, June 7, 1913; "Statistics of Post-mortems in Large Hospitals in the United States a.ndAhToad,"E.lI.LeviBskiCoib'in,Journalof the American Medical Association, June7, 1913; "Gleanings from Calcutta Post-mortem Records," Leonard Rogers, /ndio Medical Gazette, 1908-14; ''Some Diagnostic Failures," H. B. Shaw, British Medical Journal, April 18, 1914; "An Experiment in the Compilation of Mortality Statistics," Louis Dublin, Quarterly Publication American Statistical Association, December, 1914; "Inaccuracies of American Mortality Statistics," H. Oertel, American Underwriter, May, 1913; ■'Betterment of American Mortality Statistics," E. B. Phelps, American Underwriter, March, 1914; "Common Errors in Diagnosis," Adolphe Abrahams, M. D., The Practitioner, London, March, 1915. 4 STATISTICAL METHOD IN MEDICINE Difficulties of Cancer Diagnosis The practical difficulties of accurate diagnosis and uniform tumor classification are best illustrated in the elaborate discussion of swellings in- the "Index of Differential Diagnosis," edited by Herbert French, M, D., and others. New York, 1913. Even the most experienced physi- cian and surgeon must at times be seriously in doubt as to the true nature of the cancerous processes first indicated by swellings which may be quite similar, at least in their outward appearance, to an abnormal growth of a non-malignant type. Fibro-adenoma of the breast, for illustration, is a comparatively common form of benign tumor; but there are many pathological varieties, including some containing cysts and intro-cystic growths, which may or may not warrant being properly classified as malignant. Tumors of the abdominal viscera, which account for so large a proportion of the mortality from tumors of all forms, are accurately diagnosed only with considerable difficulty, particularly in the initial stages of the disease. Mechanical aids, such as the chem- ical evidence of blood in tjie feces or the determination of vegetable and bacterial organism in the gastro-intestinal tract, have not been found of much practical value, and this has been true also of radiological examinations, the ultimate diagnosis being in most cases the sum total of clinical findings by different and often widely varying methods. Cancer an Ancient Disease Malignant tumors, however, diagnosed with difficulty or classified with uncertainty, are among the oldest known afflictions of civilized mankind. The history of cancer can be traced backwards by an un- broken record to early Greece, and even to still more ancient India and Egypt, although the more remote the records, the more obscure, naturally, the description of the initial symptoms and pathological manifestations of the disease. Unquestionably Hippocrates was fairly well acquainted with cancer of the breast, and he recognized the occurrence of malig- nant disease in certain of the internal organs as well. According to Woglom, in his brief historical review of malignant disease in the "Studies in Cancer and Allied Subjects," published by the George Crocker Special Research Fund, previous to the time of the Roman physician Celsus, the term "carcinoma" included the most bizarre collection of swellings, distinguishing cancer from carcinoma, but including under the former heading many lesions which are now recognized as simply inflam- matory. Cancer was well known to Galen, one of the ancient founders of medicine, and surgical operations on account of cancer were practised by Leonidis (about 180 B. C), who was the first to appreciate the importance of the retraction of the nipple as a diagnostic sign in cancer of the breast. A review of the literature of cancer during the long intervening period of time, which practically coincides with the recorded history of mankind, would needlessly enlarge the present discussion, which has been made to include these brief medical observations for the sole purpose of emphasiz- ing the subsequent conclusion that, regardless of inherent defects in death certification, the available cancer mortality returns may, on the whole, be accepted with confidence as representing with at least approxi- mate accuracy the true local incidence of the disease and its varying THE MORTALITY FROM CANCER degree of frequency within the modern period of official death regis- tration. The history of cancer from the earhest times to the present day has been admirably brought together in a work of truly colossal magnitude by Prof. Dr. Jacob Wolff, under the auspices of the German Society for Cancer Research.* Wolff gives emphasis to the historical changes in the point of view regarding the causation, pathology and treatment of cancer, from the overthrow of Galen's theories during the sixteenth and seventeenth centuries to the far-reaching discoveries of Virchow, in 1853, and the theory of Cohnheim, in 1867, which underlie modern conceptions of tumor pathology. Place of Cancer in the Progress of Medicine Oncology as an exact science on the foundations of Virchow's cellular pathology is of comparatively recent date. Yet it is probably true that more is now known regarding the physiology and pathology of tumors than concerning any other disease, with the possible excep- tion of tuberculosis. The remarkable progress in exact tumor diagnosis during recent years is largely due to the development of microscopical science and the highly specialized efforts in modern laboratory research. Previous to the advent of biological science, much of the prevailing medical opinion regarding tumor pathology was mere guesswork, and often seriously erroneous. At the same time even a brief review of the medical literature of the last one hundred and fifty years or more, con- clusively proves the soundness of prevailing general conceptions regard- ing cancerous processes and the practical certainty that at least as regards terminal diagnosis the majority of malignant tumors were accurately diagnosed as such and correctly classified in conformity to prevaihng systems of nosology. For illustration, the observations of Samuel Sharp on encysted tumors and on the amputation of the "cancer'd" and scirrhous breast, published in his treatise on "The Opera- tions of Surgery," issued in a seventh edition, London, 1758, include the following interesting and useful remarks: The Success of this Operation is exceedingly precarious, from the great Disposition there is in the Constitution after an Amputation, to form a new Cancer in the Wound, or some other Part of the Body. TMien a Schirrus has admitted of a long Delay before the Opera- tion, the Patient seems to have a better Prospect of Cure without danger of a Relapse, than when it has increased very fast, and with acute Pain. I cannot however be quite posi- tive in this Judgment, but upon looking around amongst those I know who have recovered, find the Observation so far well-grounded. There are some Surgeons, so disheartened by the Ill-success of this Operation, that they decry it in every Case, and even recommend certain Death to their Patients, rather than a Trial, upon the Supposition it never relieves; but the instances, where Life and Health have been preserved by it, are sufficiently numer- ous to warrant the Recommendation of it. Ulcers and Cancerous Complaints Bell's treatise on "Ulcer," published in 1784, and Pearson's "Observa- tions on Cancerous Complaints," published in 1793, make now rather curious reading, in contrast with the more systematic and scientific dis- course on the "Anatomy, Physiology, Pathology and Treatment of Cancer," by Walter Hayle Walshe, published with additions by Dr. J. Mason Warren, of Boston,in 1844 ; just as the work of Walshe is in marked •"Die Lehre von der Krebskrankheit von den altesten Zeiten bis zur Gegenwart," (in three volumes) by Dr. Jacob Wolff. Jena, 1907, 1911 and 1913. STATISTICAL METHOD IN MEDICINE contrast with the recent work on the "Pathology of Growth, with Special Reference to Tumors," by Charles Powell White, or the treatise on "Cancer of the Breast, with Special Reference to Operations and Their Results," by Charles B. Lockwood, London, 1913. Classification of Cancers by Walshe (1844) In the absence of a concise definition of the term cancer or malignant disease, an exact classification of tumors is obviously impossible. Nu- merous attempts have been made to classify tumors according to funda- mental concepts derived from the sciences of anatomy, physiology and pathology, but all of these classifications vary more or less in essential matters of detail. An early classification of cancer, published in the work by Walshe in 1844, is of present interest as an aid in the interpre- tation of the cancer mortality statistics of a period which practically coincides with the beginnings of modern death registration. The classification by Walshe* is given in Table 1, Appendix A. In commenting upon this classification the author points out that can- cer as a morbid product is unequivocally separated from others belong- ing to the same class, as, for example, pus and tubercles. He also differ- entiated malignant tumors from those analogous thereto, such as fatty, fibrous and cartilaginous tumors. According to Walshe, the genus carcinoma includes three species, Encephaloid, Scirrhus and Colloid; but the term is meant to be equally applicable to all of these in every stage of their existence, before as well as after softening and ulceration. The practical diflBculties of an exact classificationf are emphasized in the statement that Each species presents a certain number of varieties. In a column apart are collected the chief synonyms, under which the species have been described by different writers. The comprehension of the work of these authors will, we trust, be facilitated by reference to this list; and the dismay naturally felt by the student on encountering in each new treatise one or more names of diseased formations seemingly distinct from all those he had previously become acquainted with, will be in some measure removed, when he dis- covers that such diversity of names by no means implies a corresponding multiplicity of things. Some of the terms contained in the Walshe classification are now obsolete and meaningless. The classification, however, emphasizes the painstaking care with which the subject was considered at a time when, according to the available mortality records, all forms of cancer com- bined, as well as non-malignant tumors, were much less frequent than they are to-day. The tumor death rate of Boston for 1840-44 was only 25.9 per 100,000 of population, which by 1909-13 had increased to 109.6. The relative frequency of cancer at different periods of time was discussed by Walshe, with special reference to early English mor- tality data, and the same question was then raised as now : whether the observed increase in the cancer death rate was real or only apparent and due to more perfect registration and increased accuracy in diagnosis. J • "The Anatomy, Physiology, Pathology, and Treatment of Cancer," by Walter Hayle Walshe, M. D., with additions by J. Mason Warren, M. D., Boston, 1844, p. 6. tSee Table 1, Appendix A. f'The Anatomy, Physiology, Pathology, and Treatment of Cancer," by Walter Hayle Walshe, M. D., with additions by J. Mason Warren, M. D., Boston, 1844, pp. 127-129. See also a paper by LeConte on "Statistical Researches on Cancer," Southern Medical and Surgical Journal, May, 1846, Vol. ii, No. 5. THE MORTALITY FROM CANCER Classification by Delafleld (1871) In 1871 Francis Delafield, M. D., who vras then the Curator of Belle- vue Hospital, published a new grouping of morbid growths, from which the colloids* included by Walshe were omitted. The classification was as follows: ^ r T 4. f Encephaloid Mahgnant|g^.^^i^^ ( Epithelioma Semi- malignant ■< Myoma (^ Enchondroma -p • ] Glandular tumors, etc., tubercle, °^ ( and some forms of hypertrophy This classification was based upon the principle that the mahgnancy of a tumor could be conclusively determined only by microscopical examina- tion and the character of the cells, whether simple or compound. The classification was a substantial advance over earlier attempts of a similar kind. The practical impossibihty of exact differentiation between mahg- nant and benign tumors is shown in the table, by the inclusion of a group of semi-malignant growths, some of which according to present theories are strictly within the malignant class. Until the cause or causes of tumor growth are known with absolute certainty, the basis for scientific classification is necessarily non-existent. It has properly been pointed out in this connection in the " Text -book of General Pathology, " by Pembrey and Ritchie, that The purpose of any attempt at classification can only be to di^-ide tumors into groups for convenience of reference. All tumors consist of cells whose appearance and quahties can usually be related to those of some normal tissue. Their outstanding feature is ca- pacity for multiplication, and this manifestation of acti\-ity, again, usually reproduces more or less closely the features of the normal development of the normal cells from which they spring. Taking advantage of this principle, it is common to found provisional classi- fications on the differential characters assumed early in embrj-onic life by the cells from which the body is built up. The rationale of such a procedure is that, once the characters of the differentiation are assimaed, they tend to be perpetuated whatever change may occur in the destiny of the dinding cell. Certain exceptions to this rule will demand con- sideration later. Some such simple classification as is given in the accompanjing table suffices for the practical requirements of the working pathologist.! Classification by Pembrey and Ritchie (1913) The classification referred to is given in full in Table 2, Appendix A. The authors of the classification frankly concede that the same is not based on strictly scientific principles, but, rather, on general usage, and they concede it to be "still extremely unsatisfactory." They point out that a large variety of names are employed, the significance of wliich can only be learned by long experience. In a general way these names indicate the tissue from which the tumor develops, the terminology being effected by the addition of the Greek afiix -ojna to the root of the term descriptive of the tissue. They add, however, to their classification the following brief and exceptionally useful explanation: A papilloma is a simple tumor of epithelial origin, and the term epithelioma is reserved The word colloid means glue-like and a colloid cancer is a carcinoma with colloid degeneration. A colloid cyst is a cyst with jelly-like contents. t"Teit-book of General Pathology," edited by Pembrey and Ritchie, London, New York, 1913, pp. 232-233. 8 STATISTICAL METHOD IN MEDICINE for malignant tumors springing from skin surfaces. The terms applied to innocent tumors springing from connective tissues constitute a large group — a, fibroma being such a tumor composed of fibrous tissue, a myoma of muscular tissue, a myxoma of mucoid tissue, a lipoma of fat, a chondroma of cartilaginous tissue, an osteoma of bone tissue. Malignant tumors springing from the same types of tissue are referred to as sarcomata. When sarcomata spring from special connective-tissue structures, there is prefixed to the word a term indicating the special tissue, e. g., myxosarcoma, chondrosarcoma, osteosarcoma. A simple tumor springing from a gland is usually referred to as an adenoma; but the term malignant adenoma is often used to designate cylindrical-celled tumors of the intestine. The greatest confusion centers round the use of the word carcinoma. This term — the scientific transliteration of the popular word "cancer" — essentially connotes the infiltra- tive capacity of a malignant growth, and has often been applied to any tumor presenting this feature. According to present clinical convention, however, it is antithetical to sar- coma, and this indicates malignant tumors of epiblastic or hypoplastic origin, the variety present in any individual case being specified by adding the name of the organ in which it occurs. Classification by Hatch (1904) The problem of tumor classification has been discussed by so many writers on cancer and allied subjects that it would be quite impracticable to review the various efforts and their advantages or defects on this occasion. In an admirable address on "Cancer : Its Origin and Successful Treatment," by Dr. J. Leffingwell Hatch, a classification of tumors was presented according to the five pathological blastodermic regions of the body, and in view of its practical utility the same is reproduced in full in Table 3, Appendix A. This and other classifications require only to be brought forward to emphasize the serious technical difficulties confront- ing the statistician in an effort to deal with the cancer mortality prob- blem in strict conformity to the principles which underlie the study of all collective phenomena or the science of averages as fundamentally conditioned by the law of large numbers. It is primarily for the purpose of illustrating the practical difficulties of the cancer problem from the medical point of view that the foregoing considerations have been taken into account in what is intended to be a strictly statistical study of a subject, which nevertheless is at root a problem of the first order of importance in biology, physiology, pathology and therapeutics. Classification by Delafield and Prudden (1913) In the Ninth Edition of the "Text-Book of Pathology," by Delafield and Prudden, it is pointed out that it is not possible to-day "to make a satisfactory scientific classification of tumors ; but the fact that they are composed of structures which resemble the various morphological types of tissue found in the normal body suggests a grouping of the various forms which may be regarded as a useful and suggestive catalogue." The classification suggested by these two distinguished authors is as follows :* • "The attempt has often been made to classify tumors with reference to the developmental history of the tissues represented, and it has been generally believed that cells once differentiated in the primary embryonic layers cannot again be merged in type. While this principle holds good in general, especially for highly dif- ferentiated forms, certain recent studies have seemed to indicate that even this distinction may not be inflexible. However this may be, it is certain that the cells derived from one embryonic layer may under special con- ditions come so closely to resemble in morphology those of another layer that a structural differentiation, with our present resources at least, is not always possible. While, therefore, this, which is called the histogenetic prin- ciple of classification, is most suggestive and may be useful in connection with other data in the study of tumors, it seems to the writer that it is wiser for the present not to base our classification too largely upon embryological data in several particulars still subject to controversy." (Delafield and Prudden, "Text -Book of Pathology," PP.367-3S8.) 9 THE MORTALITY FROM CANCER CLASSIFICATION OF TUMORS (Delafield and Prudden) Connective-tissue Type Normal Tissue Tumors Fibrillar connective tissue Fibroma Mucous tissue Myxoma Embryonal connective tissue Sarcoma Endothelial cells Endothelioma Fat tissue Lipoma Cartilage Chondroma Bone Osteoma Neuroglia Glioma Muscle-tissue Type — ^Myomata Normal Tissue Timiors Smooth muscle tissue Leiomyoma Striated muscle tissue Rhabdomyoma Nerve -tissue Type — Neuromata Vascular- tissue Type — ^Angioma ta Normal Tissue Tumors Blood-vessels Angioma Lymph-vessels Lymph-angioma Epithelial-tissue Type Normal Tissue Tumors Glands Adenoma Various forms of epithelial cells Carcinoma and associated tissues Classification by White (1914) The most recent tumor classification occurs in a treatise on "Tumors," by Charles Powell White, whose definition of a tumor is that of "a mass of cells, tissues or organs resembhng those normally present in the body but arranged atypically, which grows at the expense of the body, without subserving any useful purpose therein." The classification of tumors adopted by White is based on the three dififerent orders of units of organ- ization, that is, organs, tissues and cells. The classification is given in full in Table 4, Appendix A. The explanation of the classification is unusually lucid and is followed by an extended discussion of the different types of tumors, both malignant and benign. As regards the nomen- clature adopted, the author observes that The organomata are called teratomata from their resemblance to monsters. The histiomata are named from the tissue which forms the characteristic feature of their structure with the addition of the termination oma. This, however, is not the case with the epithelial and endothelial histiomata because the terms "epithelioma" and "endo- thelioma" are sometimes applied to certain forms of cytomata. The cytomata are properly named from the cells which form their characteristic elements. Epithelial cytomata are, however, called by the old Greek name carcinoma from the supposed resemblance of these tumors to a crab (Latin, cancer) . Supporting tissue cell tumors (desmocytomata) are named sarcomata. Collectively the cytomata are called cancers. Compound tumors are named by compound words representing the various constituents of the tumors: hence myxofibroma, osteofibroma, chondrosarcoma, etc. The classification by White is likely to prove exceptionally useful for practical purposes ; but he properly directs attention to the fact that 10 STATISTICAL METHOD IN MEDICINE intermediate and compound tumors exist which may not admit of a precise classification. In view of the importance of the carcinomata, the author's subclassification according to the type of epithelial cell of which the tumors are composed is given below: il Squamous-celled carcinoma 2 Columnar-celled carcinoma 3 Spheroidal-celled carcinoma 4 Syncytial carcinoma or syncytioma 5 Endothelial cytoma or endothelioma It would be difficult to give extended consideration to these principles of classification in the analysis of cancer mortality data. It would require in the case of each and every tumor terminating fatally that a qualified microscopical examination be made of the growth to determine with absolute accuracy its precise nature, which, aside from the impos- sibility of securing the consent of interested parties to an autopsy, might prove prohibitive as a matter of expense. The classification, however, is exceedingly interesting and valuable for scientific purposes, and it would seem to permit of being adopted, at least, by surgeons and large hospitals, with facilities for microscopical research.* The Natural History of Cancer The essential elements of the cancer problem have been discussed with exceptional thoroughness in the "Natural History of Cancer, with Spe- cial Reference to Its Causation and Prevention," by W. Roger Williams, M. D. This work includes extended observations on the geographical distribution and incidence of cancer, the observed increase in the disease, the influence of age, sex, personal history, family history, etc., and, finally, some exceptionally useful observations on quasi-malignant pseudo-plasms and the difficulties experienced in the exact diagnosis of cancers and their various causes. The considerable use of statistical data in the discussion of the geographical distribution of cancer as well as its topographical distribution throughout the United Kingdom forcibly illus- trates the practical importance of the statistical method and the possi- bilities of an increase in usefulness by more trustworthy data derived from official reports on death registration, the reports of hospitals and special institutions for the treatment of cancer, and last, but not least, the extended experience of life insurance companies. The essential statistical elements of the cancer problem are, in the order of their relative importance, age, sex, race, occupation, locality and family history. Each of these elements requires to be separately considered, with a due regard to the varieties of cancer and the organs and parts of the body affected. Among other important factors are conjugal or marital condition, religious belief, density of population and special residential conditions, topography, soil, climate, habits and personal history of past diseases, including, of course, traumatisms of every kind. When it is conceded that all of these factors more or less influ- •A tumor classification according to the histologic constituents, physical manifestations and seats of pre- dilection, by Gould and Pyle, as contained in the second edition of the Pocket Cyclopedia of Medicine and Surgery, is given in Table S, Appendix A, for convenient reference. 11 THE MORTALITY FROM CANCER ence the local incidence of cancer, it is self-evident that the statistical correlation must become extremely complex, according to the methods of analysis employed. Excepting, however, the age and sex factors, it would appear that thus far no other special conditioning circumstances affecting cancer frequency in human beings have been shown to be of sufficient local importance to invalidate general conclusions based on crude cancer death rates, not standardized for sex and for age. It would obviously he an unpardonable statistical error to compare without at least a word of caution the crude cancer death rates of long-settled countries, including a considerable proportion of aged persons, with the crude rate of a neio country consisting chiefly of immigrants and their offspring, largely of the non-cancerous period of life. As a rule, how- ever, in the absence of such a standardization for age, the crude cancer death rates are a sufficiently accurate index of local cancer frequency in the case of countries free from abnormal population conditions, such, for illustration, as are found in the excessive proportion of aged persons in a country like Ireland and the abnormally low proportion of old people found in recently settled countries or localities, as typified in the case of Australia.* The same conclusion applies to countries or localities with an abnormal sex distribution, as best shown in the case of new settlements for lumbering or mining purposes, where the popula- tion consists almost exclusively of men. The two fundamental factors which invariably condition the local cancer death rate are, first, the varying sex and, second, the varying age distribution of the population. For the large majority of civilized countries the cancer death rates are available by sex, but it is possible for only a relatively small proportion of countries and localities to calculate the required cancer death rates by sex and divisional periods of life. Standardized Cancer Death Rates The importance of these observations is concisely brought out by the following facts derived from the last annual report (1913) on the mortality of the registration area of the United States. The total number of deaths from cancer was 49,928, and of this number 20,045 were deaths of males and 29,883 were deaths of females. Since the sex proportion of the population in the registration area is almost the same, the relative cancer death rates, according to sex, differed in the proportion of 10 to 16, as determined by a male cancer death rate of 61.3 and a female cancer death rate of 97.6 per 100,000 of population for the year 1913. Since the registration area includes only about 65 per cent, of the total population, it is a safe assumption that the approximate number of deaths from cancer in the Continental United States for the year 1915 may be conservatively estimated at 80,000, and of this number 32,100 would be deaths of males and 47,900 would be deaths of females. It is therefore self-evident that in the calculation of cancer death rates, as far as practicable, the sex factor requires to be taken into account. Cancer is so peculiarly a function of age, that for the purpose of pre- cise calculation the various populations considered require to be reduced to a standard or uniform distribution, resulting in what is technically *According to recent census returns the proportion of persons aged 65 and over was 10.0 per cent, for Ireland, against only 4.3 per cent, for the Australian Commonwealth. 12 STATISTICAL METHOD IN MEDICINE known as "corrected" death rates. A more strictly scientific term would be "standardized" death rates. The importance of the age factor in cancer mortality is illustrated in the simple statement that in the United States registration area during the year 1913 out of 49,887 deaths from cancer at all known ages, 42,173 deaths, or 84.5 per cent., occurred at ages 45 and over. In the Ordinary experience of The Prudential Insur- ance Company of America, 1886-1913, the proportionate* mortality from cancer at ages 45 and over was 8.5 per cent, for males and 17.8 per cent, for females. Among insured females in the Company's Ordinary experience at ages 45 and over, cancer was the leading cause of death. In most of the civilized countries of the world the female cancer death rate exceeds the male cancer death rate, but there are some important ex- ceptions to this rule which demand special consideration. In England and Wales, in the year 1911, the crude cancer death rate of males was 89.1 per 100,000 of population, whereas the female cancer death rate was 108.8, a difference of 19.7 per 100,000 of population. The stand- ardized rates according to sex, that is, corrected for variations in the age constitution of the two populations, were 82.3 for males and 99.8 for females, a difference of 17.5 per 100,000 of population. These differences, it will be granted, are not of sufficient importance to invalidate the general conclusion that the male cancer death rate of England and Wales is normally below the cancer death rate of females. A much more pronounced difference, however, in the cancer death rates according to sex is disclosed when the rates for rural districts are compared on the basis of the necessary standardization for age and sex. According to the report of the Registrar-General for 1911, the crude cancer death rate of males living in rural districts was 90.5, which was reduced to 68.9 when corrected for age on a standardized basis, or a difference of 21.6 per 100,000 of population. The cancer death rate for females was changed from a crude rate of 113.4 to a standardized rate of 90.8, or a difference of only 12.6 per 100,000 of population. This result is accounted for by the large proportion of aged women in the English rural population, so that as a general rule the rural cancer death rates of the two sexes are more urgently in need of stand- ardization for age and sex than the crude rates of cities. f Cancer a Function of Age and Senility The age factor in cancer is unquestionably a disturbing one in general mortality statistics. The frequently expressed opinion, however, that the increase in the average duration of life during recent years is a sufiicient explanation of the apparent increase in the cancer death rate is seriously misleading. The argument that "those who to-day live long enough to be attacked by cancer would in the majority of cases, had they lived in years gone by, have succumbed earlier to small- pox, consumption and other scourges, which have since been so greatly reduced in frequency," is equally erroneous. Cancer death rates, when *The term proportionate mortality means the number of deaths from cancer in every 100 deaths from all causes at the divisional period of life specified. Additional details regarding the Company's cancer mortality experience are given in Tables 1 to 27, Appendix D. * tThe official statistics of cancer for England and Wales are contained in the annual reports of the Registrar- General of Births, Deaths and Marriages. Special consideration has been given to cancer in recent reports, particularly the 74th, 75th and 76th, for 1911, 1912 and 1913. 13 THE MORTALITY FROM CANCER calculated for divisional periods of life, measure the rate of mortality at those particular periods and without reference to any other. If it can be shown that the cancer death rate at ages 45 and over is higher to-day than in former years, the higher rate is evidence of a true increase in cancer liability among equal numbers affected and is not the result of a mere shifting in disease liability of equal degree from one group of causes to another. From a physiological point of view, the age factor in cancer is the equivalent of the observed retrogression of cells to an extremely primitive form, typical of true senility, or old age. As ob- served, however, by Sir Jonathan Hutchinson: "Sometimes it is not so much senility of the entire organism, as what we may term local senility and old age of the tissues concerned, which is primitive and does not correspond to that of the body as a whole." "Nor indeed," he con- tinues, "is it correct to say that the degree of senility is the measure of proneness to cancer, for it is not in conditions of advanced senile atrophy that cancer is most apt to occur, but, rather, in its commencement. Tissues and organs which are just commencing to decline are those which are most prone to develop it." That cancer processes are, in fact, evi- dences of a senile change seems to be well established by the researches of Hastings Gilford and others, whose conclusions are in conformity to the theory advanced many years ago by Sir James Paget regarding errors in the chronometry of life. In the words of this distinguished authority: "The local defects of working power require more often to be thought of in the time rate of life in the defective parts and we should think of the age of each part as not always wholly or exactly expressed by the time that has elapsed since it was first formed."* A reference to these observations seems pertinent as a precaution against the prevailing view that cancer is a specific function of age, instead of its being more accurately a function of senility, which as a rule by some years precedes normal old age. In fact, as observed by W. R. Williams, "centenarians and other very aged persons are shown to be little prone to malignant tumors." In contrast, it is well known that tumors occurring in early life are much more rapidly fatal than those which occur later in life. Since tumors in youth are as a rule of the sarcoma type, that is, cancers of connective-tissue formation, it is sincerely to be regretted that in most of the available cancer statistics the required distinction of carcinoma and sarcoma should not have been made, with a due regard to age and sex. The importance of such a distinction has been clearly brought out by Bashford in one of his papers on the age incidence in cancer mortality. f The Factor of Race in Cancer Mortality The race factor in cancer mortality statistics is also of considerable importance, and the cancer death rates for countries with a population consisting of widely different ethnic elements require to be corrected *See in this connection an interesting editorial in the New York Medical Record, May 31, 1902, on Errors in the Chronometry of Life, with special reference to the observations and conclusions of the late Sir James Paget. t Scientific Reports on the Investigations of the Imperial Cancer Research Fund, Part I, Statistical In- vestigation of Cancer, London, 1905. See also in this connection the tables on cancer and sarcoma, by single years of life, derived from the Industrial experience of The Prudential Insurance Company of America, in the Appendix to the chapter on Cancer as a Problem in Life Insurance Medicine. 14 STATISTICAL METHOD IN MEDICINE or given in detail on this ground. As a typical illustration the Island of Ceylon may be referred to, where the population consists of such widely different ethnic types as Europeans, Sinhalese and Tamils.* According to the hospital returns of Ceylon for 1913, out of 88,724 admissions for all causes, only 217, or 0.24 per cent., were on account of malignant growths, and 287, or 0.32 per cent., on account of non- malignant growths. Of the 217 admissions for malignant growths, 45, or 20.7 per cent., terminated fatally, whereas out of 287 admissions for non-malignant growths, 7, or 2.4 per cent., terminated in death. Another illustration is the District of Columbia, where of the total population in 1910, 28.5 per cent, were of African descent. All of the available evidence is to the effect that the recorded cancer death rate of primitive races is materially below the average for civilized countries. The argument frequently advanced that this difference is much more apparent than real is hardly applicable to the conditions under which the available information for native races has been obtained. Quali- fied European physicians practising for years among the native Egyp- tians, the primitive races of East and West Africa and the North Amer- ican Indians are in entire agreement that malignant tumors of every variety are quite rare among the uncivilized or semi-civilized types of mankind. The evidence regarding the infrequency of cancer among native races has been carefully examined and admirably set forth in "The Natural History of Cancer," by W. R. Williams; and equally convincing evidence will subsequently be presented in the statistical portion of this work. In the United States previous to the Civil War, cancer among the negro population was relatively rare,t and particularly was this observed to be true by plantation physicians as regards cancer of the uterus among negro women. At the present time, under conditions of un- restrained personal freedom, the difference in the cancer mortality of the two races is decidedly less pronounced, though, as a rule, the general cancer death rate of the white population is still considerably in excess of the cancer death rate of the negro. At ages 40 and over, for illustra- tion, the mortality from cancer of the stomach and liver in the District of Columbia for the decade ending with 1910 was 105.5 per 100,000 of population for white males, against 73.1 for colored males, and 84.5 for *During 1908-12 the cancer death rate of Ceylon by race was as follows: Europeans, 15.9; Burghers, 25.9; Sinhalese, 7.3; Tamils, 5.4; Moors, 6.5; Malays, 3.2; all races combined, 6.8 per 100,000 of population. In a letter, of May 1, 1914, Mr. Bertram Hill, Registrar-General of Ceylon, writes me as follows: "The figures in the Ceylon Vital Statistics as to causes of death must be accepted with caution. In the majority of cases diagnosis is made by persons who have had no medical training or at least no training on modern scientific lines and who probably would not be able to diagnose cancer if they came across it. Then, again, Europeans return to Europe, as a rule, if they are afflicted with any serious disease, and the age constitution of the European population is not favorable to the development of cancer; most European Civil Servants retire at the age of 55 or under and return to England for the rest of their lives. A similar practice exists among planters and merchants. There are then comparatively few Europeans over 55 years of age in Ceylon [7.1 %]. It is worthy of note that of the 406 fatal cases of cancer which were recorded in this Island in 1912 no less than 107, or 26 per cent., were due to cancer of the buccal cavity. This is attributed to the habit of chewing betel: the chew consisting of the betel leaf, tobacco, arecanut and lime. This 'quid' is kept constantly in the mouth and no doubt sets up irritation, which results in cancer. Apart, however, from the unreliability of the figures, I believe that cancer is a comparatively rare disease in Ceylon, though the rate has risen from 6.4 in 1910 to 9.8 per 100,000 in 1912. It is worthy of note that the cancer mortality in the Straits Settlements (which have a climate closely resembling that of Ceylon) was 9.6 per 100,000 last year." tSee in this connection a discussion of the mortality from tumor among the American negro population IQ my "Race Traits and Tendencies of the American Negro," New York, 1896, 15 THE MORTALITY FROM CANCER white females, against 64.5 for colored females. In marked contrast, the mortality from cancer of the generative organs in the District of Columbia was 84.2 per 100,000 of population for white women, against 123.1 for colored women. These illustrations sufficiently emphasize the importance of giving due consideration to the fundamental element of race, aside, of course, from the factors of sex and age.* Limitations of the Present Inquiry It is not the present purpose to enlarge upon the numerous factors and circumstances which condition the observed variations in cancer frequency in different countries and at diflferent periods of time. The main object is to facilitate the statistical study of the cancer problem by making available the more important general data for the civilized world, arranged as far as practicable in a uniform manner and reduced to rates calculated by uniform methods. The available amount of statisti- cal information is of astonishing proportions. Most of the original reports containing cancer mortality statistics are unavailable to the student of the subject from the medical and surgical point of view. There is much pretended accuracy in numerous statistical tabulations which, however, are often found wanting, in that widely varying methods of estimating the population have been employed and frequently no correction has been made for changes in population during intercensal periods. Even some of the more pretentious international tables of cancer statistics fail in the matter of accuracy of detail, f It has there- fore been necessary for the present purpose to reconsider the entire material, and unless otherwise stated, all of the tables presented are derived from official sources, that is, either from the original official reports on mortality or by means of correspondence with the registra- tion officials in charge. The populations for intercensal periods have as a rule been recalculated, in conformity with the arithmetical method. The rates have been checked at least twice throughout, but, consider- ing the vast amount of material brought together, from so many different sources, absolute accuracy must be assumed unattainable. The chief purpose of the present investigation, as stated before, is to make the existing statistical data available to the student of the subject, to whom most of the facts would otherwise be inaccessible. A second important object has been to determine the true tendency of the cancer death rate, or, in other words, the rate of increase or decrease in cancer mortality throughout the civilized countries of the world. The controversial aspects of the question as to whether cancer is on the increase or not are separately considered in another portion of this work. A third object of the present inquiry has been to ascertain as far as practicable the relative incidence of cancer according to the organs or •Proportion of Negro Population, Census 1910: Charleston, S. C, 52.8 per cent., Mobile, Ala., 44.2 per cent, and New Orleans, La., 26.3 per cent. tThe principal sources of international cancer statistics are: Statistique Internationale du Mouvement de la Population d'apres les Registres d'Etat Civil (publiee par le Ministere du Travail et de la Prevoyance Sociale, Paris, 1907 ot 1913); Statistique Demographique des grandesVillesdu Monde pendant les Annees 1880- 1909 (publiee par le Bureau Municipal de Statistique d'Amsterdam); Annual Reports of the Registrar-General of Births, Deaths, and Marriages in England and Wales. See also in this connection the discussion on Cancer in the first volume of "Handworterbuch der sozialen Hygiene," by Grotjahn and Kaup, Leipzig, 1912, and the section on Statistics in the third volume of "Lehre von der Krebskrankheit," by J. WolEf, Jena, 1913. 16 STATISTICAL METHOD IN MEDICINE parts of the body affected, with a due regard to age and sex, in different countries of the world. It is a remarkable fact that for most of the countries the required information is not available. Absolute complete- ness in the tabular analysis has therefore not been attainable; but every effort has been made to present the more useful data, at least, for the countries with admittedly trustworthy systems of registration, based upon reasonably accurate methods of death certification. Urgency of Complete Information The difficulties of statistical research into the cancer problem are needlessly increased by the common neglect on the part of those re- sponsible for the official publications on cancer mortality to provide the necessary information as regards the organs and parts of the body affected. The rather common practice of only assigning cancer as a cause of death, without regard to the organs or parts of the body affected, materially impairs the practical utility of the available information. The conviction, however, is gradually gaining ground that the required details with regard to cancer are as essential as they are with regard to fevers. It would be as logical and as useful to return deaths from fevers without stating whether typhoid, malarial or some other form as it is to return deaths from cancer without stating whether of the stomach or liver, the uterus, the breast, etc. Such details are absolutely indispen- sable to the more scientific purposes of statistical research into the natural history of malignant disease. It does not involve much additional labor on the part of the attending physician to enter on the death certifi- cate the particulars as regards the organ or part of the body affected by the cancerous growth causing death, but the absence of such informa- tion often precludes the highest attainable degree of completeness in the practical use of cancer mortality returns; in its final analysis the question as to whether cancer is on the increase or not reduces itself to the problem as to whether cancer of any particular form or type is more or less prevalent now than in former times. It has probably never been seriously maintained by any one at all familiar with the subject of cancer mortality statistically considered that all forms of cancer were on the increase, any more than one would be justi- fied in concluding that because the general death rate is declining the decrease in the rates affects every disease or cause of death. It should be perfectly obvious that the general death rate may be decreasing re- gardless of the fact that the rate is increasing at certain ages or from certain causes; and the general death rate from cancer may be increas- ing regardless of the fact that there may be a decline in the frequency of malignant disease as affecting certain organs or parts, or certain special elements of the population, particular age groups, etc.* *The argument has been put forward by the Director of the Imperial Cancer Research Fund that "All the statements widely circulated in the newspapers as to the increase of cancer as a whole should be ignored and attention only paid to those in which cancer affecting the different parts of the body are considered." This conclusion is not justified by the facts, for as a general principle it may safely be asserted that cancer of all im- portant organs and parts of the body is on the increase in most of the localities for which the data are available and that the occasional exceptions to the rule as regards cancer of particular organs or parts of the body which may show a decline are not of equal importance. Of course, the rate of increase for the various organs and parts of the body varies widely, but this does not affect the broad conclusion that malignant disease, considered as a group, shows a decided tendency towards an increase, relatively to the population affected, throughout the civilized world. 17 THE MORTALITY FROM CANCER The Problem of Cancer Increase In the classical essay on "The Alleged Increase of Cancer," by Messrs. King and Newsholme, originally read before the Royal Society on May 4, 1893, the statistical study of the material considered was arranged according to external or accessible cancers and internal or inaccessible cancers. The grouping adopted was rather arbitrary and in some re- spects misleading, as wiU be subsequently shown in the more extended discussion of the question as to whether cancer is actually on the increase or not. In a corresponding study made by the Imperial Cancer Re- search Fund three groups of cancerous affections were adopted, accessible, inaccessible and intermediate. It is self-evident that cancer diagnosis must be decidedly more difficult in the case of inaccessible cancers than in the case of those conveniently accessible by means of external exam- ination. The classification, by Bashford, of accessible, inaccessible and intermediate cancers, the terms referring, of course, to the seat of pri- mary, growth, is of much practical value, and for this reason the same is given in full in Table 8, Appendix A, together with a note on the original classification adopted by King and Newsholme. Effect of Better Diagnosis on Cancer Statistics Improved diagnosis, especially when based upon autopsies followed by the microscopical study of the tissues affected, must necessarily tend to increase the cancer death rate; but there are reasons for believing that this factor of uncertainty in cancer mortality statistics is not of suffi- cient importance to seriously invalidate the practical utility of the general cancer death rate. For even in the case of autopsies, mistakes in diag- nosis, as conclusively shown by Dr. Bashford, are not entirely avoidable. The margin of error is probably not, however, as wide in cancer death certification as is frequently assumed to be the case. The liability to error is perhaps as great, if not greater, in the classification of cancer mortahty returns reported originally in conformity to a more or less indefinite medical terminology. As previously shown the earlier classi- fications of tumors, whether malignant or benign, indicate that the tendency to classify benign tumors as malignant was probably greater than the liability in modern medical practice to erroneously diagnose malignant growths as tumors of an innocent kind. That within recent years there have been further improvements in diagnosis can not be questioned by any one familiar with the progress of medical science in this and other countries. That there have also been improvements in the more scientific classification of diseases must be readily admitted, and more so in view of the increasing use of the International Classifica- tion of Causes of Death, which in the case of cancer provides for seven large groups and numerous subdivisions under each. The Place of Cancer in Death Classification The term "cancer," for statistical purposes, as explained in the Manual of the International List of Causes of Death, is a general one, and made to include all forms of malignant neoplasms. The list of these, as given in the original classification, is given in full detail for the purpose of convenient reference, in Table 6, Appendix A. It is stated in the Manual that "the location of the cancer, or preferably, as recommended by the 18 STATISTICAL METHOD IN MEDICINE Committee of the American Medical Association, the seat of origin of the cancer, if known, should always be stated." The seven groups adopted for general purposes of classification are: first, cancer and other malignant tumors of the buccal cavity, second, cancer and other malig- nant tumors of the stomach and liver, third, cancer and other malignant tumors of the peritoneum, intestines and rectum, fourth, cancer and other malignant tumors of the female generative organs, fifth, cancer and other malignant tumors of the breast, sixth, cancer and other malignant tumors of the skin, seventh, cancer and other malignant tumors of other organs or of organs not specified. With regard to the last, it is pointed out that "This is a residual title that includes all deaths from cancer that cannot be assigned to the preceding titles, and espe- cially those in which the location or origin of the disease is not stated." It is suggested that "inquiry should be made in such cases and fuller information obtained, if possible."* In the subsequent discussion of the cancer statistics of the United States registration area by organs and parts of the body, only these seven groups are considered, since the information in detail for the numerous subdivisions is not at present made public by the Division of Vital Statistics of the Census Office. An urgent recommendation has therefore been made to the Director of the Census by the Executive Committee of the American Society for the Control of Cancer that this omission should be made good in the future by the more complete publication of the facts, or, in other words, the publication of cancer mortality returns in full detail, according to the organs or parts of the body affected. It is to be hoped that this suggestion will be carried into effect in the publication of future reports on the mortality statistics of the registration area.f For the scientific study of the cancer problem it is, however, of the utmost importance that the available statistical information should be published in more detail, and several suggestive illustrations of the feasibility of this method are given in statistical appendices, particu- larly in Appendix G, for foreign countries. The earlier returns in detail for New York and Philadelphia may also be referred to as decidedly more useful than the abbreviated statistics published at the present time, in conformity, however, to the International Classifica- tion of Causes of Death. Non-Malignant Tumors The Manual of the International List of Causes of Death classifies other tumors, excepting those of the female generative organs, as a * See Tables 6 and 7, Appendix A. tin conformity to this resolution the Director of the Census has given instructions to the Division of Vital Statistics to make hereafter the following subdivisions in the cancer classification: CANCER AND OTHER MALIGNANT TUMORS OF THE— 39. Buccal cavity 40. Stomach and Liver 41. Peritoneum, intestines and rec- Lip Pharynx tum Tongue ' (Esophagus Mesentery and peritoneum Mouth Stomach Intestines Jaw Liver and gall-bladder Rectum Other Other Other 42. Female Generative Organs 45. Other organs: Larynx, Lungs and Pleura, Pancreas, Kidneys and 43. Breast Suprarenals, Prostate, Bladder, Brain, Bones (except jaw). Testes. t4. Skin Other. ]9 THE MORTALITY FROM CANCER separate group, including all forms of non-malignant neoplasms. These are quite numerous and on account of their importance the details are given in full in Table 6, Appendix A, as derived from the official classification of Causes of Death. Non-cancerous uterine tumors are also separately considered in the International Classification and the details of this group are given in Table 7, Appendix A, together with the official list of cysts and other tumors of the ovary, hydatid tumors of the liver, biliary calculi, calculi of the urinary passages and ulcers of the stomach; it being understood, of course, that in all cases the supplementary classification applies only to non-malignant disease, and that the facts having reference thereto are included in this dis- cussion only as a matter of convenience for the more complete study of tumor science comprehended under the term oncology.* *0n the classification of diseases, with special reference to cancer, see Bellevue Hospital Nomenclature of Diseases and Conditions, adopted by the Board of Trustees, 1903, revised edition, 1911 ; Massachusetts General Hospital Nomenclature, second edition, revised and enlarged, 1914; Statistical Experience Data of Johns Hop- kins, Hospital, Baltimore, 1892-1911, F. L. Hoffman, 1913, including observations on the plan and scope of nosography, Bellevue classification of diseases, and a list of references to disease registration and the practical utility of institutional and other mortality records. 20 CHAPTER II THE STATISTICAL BASIS OF CANCER RESEARCH Limitations of Statistical Analysis — DiflSculties of Precise Classification — Early Obser- vations on Cancer Statistics — Need of an Exhaustive Study — Uniform Methods of Tabulation and Analysis — Recognition of Cancer — Importance of Microscopical Research. The sources of statistical information regarding cancer frequency throughout the world are : first, the official mortality statistics, second, the statistics of institutions for the medical or surgical treatment of cancer patients, third, the recorded individual clinical data of physi- cians and surgeons, fourth, the collective experience data of life insur- ance companies, fifth, the results of special cancer censuses, sixth, mis- cellaneous data of public institutions, such as homes for the aged, almshouses, prisons, retreats for inebriates, etc. Recognized Limitations of Statistical Analysis Of the world's population, estimated for 1912 at 1,750,000,000, there are more or less trustworthy cancer mortality statistics for a population of about 450,000,000, or 26.0 per cent, of the whole. For this civilized portion of the world, the intrinsic value of the data available varies quite considerably, not only for the different countries as such, but also for the several component parts of the same country , that is,the political divisions or subdivisions as the case may be. The liability to error in the interpre- tation of cancer statistics is therefore quite serious and no conclusions advanced in the subsequent discussion are to he accepted without this impor- tant qualification. As is the case, however, in all mortality statistics, there is a well-establistied tendency on the part of such errors to more or less balance one another; and the observed regularities in cancer occurrence in different countries and different sections of the same country warrant the conviction that the element of error in cancer statistics is apparently not materially greater, if as great, than in the case of other important diseases, such as typhoid fever, appendicitis, diabetes, etc. The initial liability to error in cancer statistics is naturally the ever-present possibility of mistakes in clinical diagnosis. This liability, however, has probably been more clearly recognized in cancerous complaints than in many other diseases of modern life, as brought out in an interesting early treatise on " Diseases Which Have Been Confounded with Cancer, and Also Some Critical Remarks on Some of the Operations Performed in Cancerous Cases," by John Pearson, Surgeon of the Lock Hospital, Lon- don, 1793. As observed by this author: For as language is not rich enough to furnish words that will perfectly denote all the different shades of colour, though their dissimilitude is obvious when presented to the mind; so there is a species of practical knowledge, composed of simple ideas derived from observa- tion, for which no competent terms have yet been contrived, and which no periphrasis can adequately describe. Pearson was evidently a careful observer, for he remarks: The application of analogical reasoning to diseases, is a very nice and delicate imder- taking; it requires much acuteness and sagacity, and lies not within the province of 21 THE MORTALITY FROM CANCER an ordinarj' observer. But in practice it is often of more importance to discern wherein complaints differ, than wherein they agree; and that sort of knowledge which might very properly enable a man to found classes, orders, genera and species, would be quite insuflB- cient to conduct him to a rational and successful mode of treatment. While nosologists therefore are debating whether the cancer ought to stand in the class of cachexiae or locales; let us pursue a more interesting object, and endeavor to ascertain by what signs the Cancer may be distinguished from all other diseases. Present Difificulties of Precise Classification This question of exact diagnosis, differentiation and classification has not yet been answered to the satisfaction of the medical and surgical profession. Criticisms, therefore, of faulty cancer statistics lie primarily against those who are responsible for errors in diagnosis and mistakes of subsequent classification, and not against those who perform the equally arduous though perhaps mechanically less difficult task of statistical tabulation and analysis. Even in so modern a work as the "Index of Differential Diagnosis of Main Symptoms," by various writers, edited by Herbert French, M. D., and published in a new edition in 1913, tumors are considered under the general term of "Swellings," because of the practical impossibility of a precise differentiation between tumors of doubtful malig- nancy and tumors of doubtful innocency, as well as between mere swellings which fall within the characteristic tumor class and those which obviously do not belong there.* The same argument, of course, may be applied to ulcers, which are also quite difficult of precise classi- fication; and reference may be made here to a treatise on "The Management of Ulcers," with a dissertation on white swellings of the joints, including observations on cancerous ulcers and the causes of cancerous disorders, by Benjamin Bell, M. D., published in 1784. An extended review of the early medical literature on cancer fails to reveal the required evidence of serious misconception of the nature of cancerous complaints in different parts of the human body sufficient to discredit the practical utihty of the available vital records with reference to this disease or group of diseases, f It is nearly seventy years ago since the statistical aspects of the cancer problem were first discussed in the United States, in a contribution by John Le Conte, entitled "Statistical Researches on Cancer," published in the Southern Medical and Surgical Journal for May, 1846. The data used were the statistics of the Department of the Seine for the eleven years ending with 1840 and the statistics of England and Wales for 1838-39. Le Conte directed attention to the necessity of sound *In the words of Mitchell Banks, as quoted by Coley, in a discussion of the increase of cancer in a paper read before the Southern Surgical and Gynecological Association, December 14, 1909, "While the diagnosis of cancer is probably made much more frequently now than in former times, it required little skill to make the diagnosis at the time of the death of the patient. The diagnosis at such a time was by no means beyond the ability of even the rural practitioner of fifty years ago." fThe following definition of cancer is from "The Physical Dictionary," by Stephen Blancard, M. D., 6th edit., London, 1715 : "Cancer : The Cancer is a round, livid or blackish Tumor, circumscrib'd with turgid Veins replete with Blood, either with or without Exulceration, arising from black, corrupted stagnant Bile diversify 'd many ways. The true Cancer is restrained to the Breasts only of Women, and the Scapulae of Men. There is a white Cancer, which is a certain white Chalky Recrement occupying the inward parts of the Mouth, and the whole Tongue of Infants ; and, except deterg'd and cleans'd in time, will exulcerate." "Carcinoma, Carcinus, or Cancer, a Tumour that arises always in the Glands, from saline, sulphureous, sharp, and melancholy thick Humours. It is round, hard, livid, painful, at the beginning as big as a Pea, but afterwards it is surroimded with great swelling Vei7is which resemble the Feet of a Crab, tho' not always." 22 STATISTICAL BASIS OF RESEARCH statistical methods and particularly to the fallacy of determining the rate of cancer frequency in the form of a proportion of the mortality from all causes. Le Conte contributed a subsequent paper on "Vital Statistics Illustrated by the Laws of Mortality from Cancer" to the Western Lancet, March, 1872, and the earlier papers, in part, with ma- terial additions, were reprinted in a final contribution on "Vital Statis- tics and the True Coefficient of Mortality Illustrated by Cancer" to the tenth biennial report of the State Board of Health of California, Sacra- mento, 1888. The fundamental principle that the mortality from cancer is a function of age was clearly recognized by Le Conte, and he was one of the very first to direct attention to its importance in statistical research. The article also draws attention to the fact that Nearly all of our statistical data appear to indicate that in the case of cancer there has really been a secular increase in mortality, both in France and in England and Wales. It would be premature to attempt to express this increment in numbers as a time-factor in our formula for the influence of age on the mortality from cancerous diseases. The rational discussion of such questions must be postponed until some zealous investigator of vital statistics arises, who has the leisure and the courage to properly analyze the vast accumu- lation of valuable facts which are entombed in the mortuary registers of the last forty years. As regards the probable cause of this presumed increase in the mor- tality from cancer, it is pointed out by Le Conte that it may be proper to remind the reader that To some extent, the augmentation may be only apparent; since it may arise from more careful registration, from improvements in pathology, and from greater accuracy in diagnosis. It is difficult to estimate the influence of these circumstances. But there is another cause of this apparent increase of mortality which is far more definite. It is a well established fact, that the mean duration of human life has, even within a comparatively short time, been sensibly increased, by the rapid advancement of medical science and by a more philosophical application of hygienic and sanitary regulations. In a footnote to the article a reference is made to one of the earliest papers on the increase in cancer, contributed to the Transactions of the Society of the Alumni of the College of Physicians and Surgeons of the State of New York, 1842. The possible effect on the cancer death rate of improved methods of diagnosis and death certification on the basis of autopsies was clearly recognized by Le Conte, who remarks that Perhaps the habit of making necroscopic examinations may be more common in the French metropolis than it is in England, and thus a greater number of internal cancers may be detected and registered. But it is hardly reasonable to suppose that the dis- parity growing out of this circumstance would amount to the enormous proportion of 4 to 1, In view of M. Tanchou's idea, that the mortality from cancer is in a direct ratio to the intensity of human ci\'ilization, it may be, to some extent, consolatory to the inhabitants of England to discover that their more recent mortuary records, from 1860 to 1863, inclusive, indicate a very remarkable increase in the death rate from this disease.* Considering the very limited amount of accurate statistical informa- tion available at this period, the general conclusions arrived at by Le Conte are in remarkable conformity to the facts disclosed by subsequent experience. The article is an illuminating contribution to the statistical *Probably the very earliest cancer mortality statistics are contained in the "Collection of the Yearly Bills of Mortality, 1657-1758," London, 1759. The returns are limited to the city of London. Cancer is specifi- cally enumerated during every year, but the term includes gangrene and fistula. Excluding the years during which plague was epidemic it is found that between 1651-1758 out of 1,980,037 deaths from all causes 5,123, or 0.26 per cent., were from cancer, including gangrene and fistula. The proportion was highest during 1651-64, or 0.34 per cent., and lowest during 1741-58, or 0.20 per cent. (See Table 15d, Appendix G.) 23 THE MORTALITY FROM CANCER study of cancer and conclusively proves that for some seventy years at least the question of cancer increase has received more or less quali- fied and critical consideration in the United States. Observations on English Cancer Statistics As early as 1866, in a paper contributed to the Journal of the Royal Statiscal Society of London, Dr. W. L. Sargant, in an essay on the "Vital Statistics of Birmingham," observed that Of all the diseases to which a separate column is assigned, the one, I presume, about which there can be the least dispute is cancer. The number of deaths it causes is small, however, being only about 1 per cent, of all deaths; but it is twice as great among females as among males. The uniformity of the numbei- in different places is remarkable. In the whole of En- gland and Wales, out of 10,000 persons living, 2 males and 4 females die of cancer each year. The same number, 2 males and 4 females, die of it each year in Liverpool, Manchester, Leeds and Wolverhampton. In Birmingham and Sheffield, there are also 2 male deaths, but 5 instead of 4 females; in London, again, there are 2 males, but 6 females; in Bristol there are no less than 4 males and 6 females. Possibly the excess in these towns is caused by the influx to the hospitals of patients from a wider neighborhood. At a meeting of the British Medical Association lately held in Leamington, there arose a discussion on the question, whether cancer was a local disease, or whether it was a result of an ill condition of the body. If it were a result of ill condition, we should find more of it in an unhealthy place than in other places; more in Liverpool than in the whole of Eng- land and Wales. But in fact we find that out of 10,000 persons living, the same number die in Liverpool that die in the whole country.* Medical progress varies widely in different countries and at different periods of time. New diseases are recognized in some countries far in advance of others, in consequence of better methods of medical educa^ tion, postgraduate courses, facilities for research, etc. ; but there would seem to be no exception to the rule that until about fifty years ago all cancerous complaints, whether external or internal, were considered by the medical and surgical profession as of comparatively rare occurrence. This conclusion is reflected in the general vital statistics of civilized coun- tries previous to about 1880, in the early experience of life insurance com- panies and in the early medical literature on the subject. During the last fifty years, however, the gradual increase in cancerous complaints has been more and more recognized, and the following is a suggestive ex- tract from a discussion in connection with the accuracy of statistics of the causes of death by Longstaff , a painstaking student of statistical problems, contributed to the Journal of the Royal Statiscal Society of London, t in which it is said that Cancer, in contrast to renal disease, is twice as fatal to women as to men: it is rare in early life, but steadily increases in frequency from the age of 25 upward. Cancer has in- creased 38 per cent, in males, 24 per cent, in females, the greater increase in males being probably due to the fact that cancer of the stomach and liver, which is commoner in men than women, is much more difficult of diagnosis than cancer of the female breast or of the uterus. Hence improved medical skill affects the retm^ns for it more. The loss of life due to the increased mortality from cancer amounts to 1,187 males and 1,661 females, of which seven-eighths are above the age of 45. A recent writer (H. P. Dunn, F. R. C. S., in British Medical Journal, 1883, pp. 708, etc.), said he was convinced that the long- continued and steady increase of cancer was not apparent only, and accounted for by in- creased accuracy of diagnosis and registration, but was an undoubted fact; the cause is quite unknown, but must probably be sought in some abnormal circumstances of our *"The Vital Statistics of Birmingham and Seven Other Towns," by Dr. W. L. Sargant, published in the Journal of the Royal Statistical Society, London, 1866. t Journal of the Royal Statistical Society, London, 1884. STATISTICAL BASIS OF RESEARCH artificial existence. It should be remembered that very few, if indeed any, recover from this much dreaded disease, and also that it chiefly attacks after the reproductive age is past. From these facts we may draw the consolation that if there are many killed, there are no wounded, and that although the tendency to cancer may be handed down to ofiFspring, they are not born enfeebled in consequence of their parents' ailment. WTien this was written the number of deaths from cancer, including sarcoma, in England and Wales was 15,198, equivalent to a cancer death rate for the year 1884 of 56.5 per 100,000 of population. For the year 1911 the cancer death rate of England and Wales was 99.3; if, therefore, in 1884, on account of mistaken diagnosis or erroneous classification, the true cancer death rate had been the same as in 1911, 26,725 deaths would have been assigned to other causes instead of being properly assigned to cancer or sarcoma. Considering the then attained degree of medical education and professional efficiency, this would seem incredible. Modern Improvements in Diagnosis and Classification At the same time, there can be no question of doubt that improved diagnosis and more scientific methods of classification have contributed towards the observed increase in the cancer death rate of practically every civilized country throughout the world; but it would seem quite impossible, considering the very material rise in the cancer death rate during the last thirty or forty years, that this increase should be only apparent and not real, and chiefly the result of improved methods of diagnosis and classification. If the same argument were applied to many other diseases, even more obscure and difficult of exact diagnosis than at least the external cancers, it would amount to this : that deaths must have actually occurred which are not a matter of official record, in view of the fact that in practically all of the more important countries the mortality from all causes has relatively declined during the last gener- ation.* Since there has been no material increase in the death rate from all causes at ages over 40, and in the case of some important causes even a decline, it is evident that if cancer ranks to-day foremost among the diseases showing an actual rise in the rate, and practically from year to year for more than a generation, this increase can not possibly be ex- clusively or even largely the result of improved diagnosis or more scientific methods of classification. Necessity for an Exhaustive Study Thus far no thoroughly scientific study of cancer statistics has been made with a view to determine the relevancy of the criticism frequently made against the validity of the statistical method. The need of such an investigation is quite obvious; but the difficulty lies in the required dual familiarity with both the medical and the statistical difficulties of the problem. In this respect the criticisms of the statistical method in cancer research on the part of the Director of the Imperial Cancer Research Fund are merely negative and of very limited practical utility. The same conclusion applies in part to the following observations by Delafield and Prudden, in the ninth edition of their "Text-book of Pathology," page 353, published in 1911: It has become e\'ident of late that much of the statistical lore of tumors, especially of malignant types, which has been handed on from one writer to another, is in need of a *For a discussion of the decline of the death rate throughout the world, see my address on " The Signifi- cance of a Declining Death Rate," proceedings First National Conference on Race Betterment, 1914. 25 TEE MORTALITY FROM CANCER critical re^Tsion, and that many of the current opinions regarding malignant tumors are based upon alleged observations of doubtful validity and upon inferences hastily and illogi- caliy drawn. Among these opinions needing revision may be mentioned the alleged rela- tive rapid increase in the frequency of cancer, which rests upon data obviously faulty; the contention that metastases in maUgnant tumor are closely analogous with metastases in infective processes and indicate the infective nature of the former; the view that carcinoma has been in many instances directly conveyed by contact from a ^'ictim of the disease to a well person; the successful inoculation of carcinoma of man into the lower animals. None of these points has been sustained by rehable data. It has become e\"ident that a new departure is necessary in the study of tumors and that this is especially urgent along two lines: first, in the collection of more rehable statistics, which shall embrace not only man, but the lower animals as well; and, second, the initiation of careful and extended experimental studies of the tumors, especially the mahgnant tumors, of the lower animals, in which such gro-nlhs frequently occiu" spontaneously. TMien along these lines the data relating to the biology of tumors shall have been gathered on a large scale, the outlook will be brighter for the study of the fundamental problems of the inciting factors in tumors and of promising measures for their treatment. Of these interesting suggestions, the first, regarding the collection of more reliable statistics, can be complied with at the present time only to the extent of a more complete and trustworthy presentation of the avail- able official and other statistical data relating to the cancer problem in its various aspects throughout the world. Since no such effort has heretofore been attempted in a really comprehensive manner, it is to be hoped that if the present work falls short of providing an absolutely trustworthy basis of conclusions regarding the apparent or actual in- crease in cancer frequency, the very considerable amount of statistical material brought together will, for the first time, at least afford an adequate basis of facts for the strictly scientific and critical statistical study of the subject. The material presented is so extensive in the quan- tity of data and the wealth of detail that it may safely be asserted that no problem in human mortahty has heretofore been considered on the basis of an equally adequate amount of statistical data. On the basis of this information it should not be impossible to ascertain with approxi- mate accuracy at least the direction in which the required improve- ment in cancer statistics can be made with least difficulty and with the assurance of practical utility. The statistical aspects of the cancer problem, with a due regard to the geographical distribution of the disease, have been considered at some length in the third volume of the treatise on cancer by J. Wolff. The statistical references, however, are general, and no attempt is made at correlation or uniformity in the presentation of the facts. Many of the citations are very interesting and exceedingly useful in the statistical study of the cancer problem; but the data are inadequate for the pur- pose of determining the true rate of increase in cancer frequency in civilized countries, not only for all forms of cancer, but for special forms in particular localities. The investigation by Wolff includes topo- graphical and geological considerations, climate, race, religion, urban and rural conditions, wealth and poverty, occupation, sex, age, etc. The results of the investigation are summarized by this author for the purpose of answering the question as to whether cancer is actually or only apparently on the increase, but no definite conclusion is reached. In brief, it is said that the evidence is not available to prove that there has been an actual increase in cancer mortality, especially of gastric 26 STATISTICAL BASIS OF RESEARCH cancer, and that, in any event, the observed increase is not sufficient to cause serious apprehension on the part of the pubHc. This conclusion is not in conformity to the results of the present investigation, which prove that within less than forty years the rate of mortality from cancer has practically doubled and that the actual number of deaths from cancer in the civilized portion of the world for which reasonably trust- worthy data are available exceeds 500,000 per annum. Uniform Methods of Tabulation and Analysis The material for the present investigation has, unless otherwise stated, been derived from the original official reports or by means of correspondence with the official department in charge of the collection of cancer mortality statistics. As far as practicable the sources of in- formation are indicated for every table, so as to facilitate further research with particular reference to the mortality experience of foreign countries. It has not been feasible, as a rule, to bring the data further down than to the end of the year 1912. The tabulation and analysis of each country as far as practicable are made to include the mortality by organs and parts of the body affected, with the required distinction of age and sex. The mortality rates are given in a uniform manner, on the basis of 100,000 of population. With but a few exceptions, the rates are original calculations based upon new or revised estimates of the population for intercensal years. The age and sex distribution of the population has, as a rule, been derived from the official census reports. The use of non- official data has generally been avoided, but occasionally such data have been included for the purpose of completeness, with the reason- able assurance that the authors responsible therefor had derived their original returns from trustworthy sources. The present discussion does not include an extended critical study of new statistical methods of cancer research. It has seemed of more prac- tical importance to provide the student of the cancer problem with the available material for statistical research, rather than with theories or criticisms however well justified by the facts. It would unquestion- ably serve a most useful purpose if the method originally suggested by the Director of the Imperial Cancer Research Fund regarding uniform records of hospitals in cancer cases were adopted by at least the lead- ing institutions providing medical or surgical treatment for cancerous complaints. Such uniformity would go far towards eliminating serious errors, which to a considerable degree invalidate the comparative cancer statistics of different countries of the world. The same conclusion, of course, applies to the general adoption of the standard death certificate and the more general use of the international classification of causes of death. Another difficult problem in this connection is the universal adoption of a generally suitable blank for supplementary cancer inquiries. As an aid towards the better solution of this phase of the cancer problem, the most essential forms in practical use are given in Appendix B. 27 CHAPTER III THE INCREASE IN CANCER Early Mortality from Cancer in London — Causes of Local Variations — Argument by King and 5s"ewsholme — Statistics of Frankfurt a/M. — Increase in Cancer by Organs and Parts — Utility of a Cancer Census — Cancer among Primitive Races — Statistical Problems of Erroneous Diagnosis — Evidence of Cancer Increase throughout the World — [Misleading Statistical Observations — Useless Controversies — Trustworthi- ness of American Mortality Statistics — Contributory Causes of Death in Cancer — Continued Increase in Cancer Frequency — Public Menace of Ignorance and Indifference. The question whether cancer is on the increase is one of the most important problems in modern medicine. If cancerous complaints are actually and relatively more frequent at the present time than in former years, it is self-e\ddent that the underlying causes or conditioning circumstances must be of recent development and the result of changed methods of living or of profound modifications in the human environ- ment. If cancer is not on the increase, but is actually a much more common disease than was generally assumed to be the case in the past, because of misleading statistics or superficial and imperfect diagnosis, then the more trustworthy returns for the present period serve the ex- tremely practical purpose of emphasizing the serious menace of cancer and the supreme importance of more qualified medical and surgical consideration of the subject. For it is self-e^ddent that if the charge is true that in the past a large number of deaths have been erroneously recorded as due to other causes than cancer, when, in fact, such deaths were due to cancerous complaints, the medical and surgical profession must have been grossly derelict in its duty and inconceivably incom- petent, considering the high degree of attained proficiency in other branches of medicine and surgery. There are the strongest possible reasons for belie%ang, however, that this lamentable conclusion, which would be virtually equivalent to a charge of gross malpractice against the world's medical profession, is not true. Those who maintain that cancer is not on the increase, but that the higher recorded rate of frequency at the present time is but an evidence of erroneous diagnosis or wrongful classification in the past, can not be aware of the far-reach- ing significance of their conclusions when concretely applied to the cancer problem. For illustration, in the registration area of the United States, during the decade ending with the year 1913, the recorded can- cer death rate increased from 70.2 to 78.9. When these rates are applied to the population of the continental United States as a whole, it appears that during this period there were 658,139 deaths from cancer. If, however, the rate for all the years previous to 1913 was deficient in ac- curacy, and if, in fact, the rate for that year, given as 78.9, had actually prevailed during each of the previous years, there would have been 706,752 deaths from cancer, or a difference of 48,613. It would seem utterly inconceivable that this number of cancer deaths should have oc- curred in the United States during a single decade and been erroneously 28 THE INCREASE IN CANCER diagnosed as due to some other disease than cancer. During recent years, however, the cancer death rate has not increased quite as rapidly as during earher periods, and the contrast would therefore be much more marked if the actual effect of the assumed errors in registration and diagnosis were calculated for a longer period of time. No one familiar with the facts can question the view that many years ago cancers of the internal organs were quite frequently diag- nosed in error, or in any event classified superficially under some other term. Walshe, in his treatise on "Cancer," published in 1844, took occasion to point out that the mortality attributed to cancer was in all probability below the true mark, particularly of those under the head of diseases of the generative organs, especially of the uterus. He remarks : A large proportion was in all likelihood caused by carcinoma; the same is true, though to a less degree, of fatal cases of organic disease of the intestinal canal and of "stricture of the rectum and oesophagus" in persons of advanced age. Whether the frequency of cancerous disease is on the increase is a question of consider- able interest, but one to which we cannot unfortunately furnish any very satisfactory reply, as we have not the means of ascertaining the proportion of the population annually cut off by the disease during a series of years. The only statistical facts we can find bearing on this question are given in the following table, showing the ratio of cancerous deaths to the total mortality of the metropolis during the last century. Mortality from Cancer in London, 1728-1838 Proportion of Deaths Time from Cancer in Every 1,000 Deaths From 1728-1757 (SOyears) 2.0 From 1771-1780 (lOyears) 3.4 From 1831-1835 (5 years) 4.4* From June 31, 1837, to December 31, 1838 (18 months)!- ..6.1 In commenting on this table, Walshe points out that From this it would, on first view, appear that the frequency of the disease has been steadily increasing during the last 100 years; but the real causes of the augmented ratio are more likely to be the decrease of mortality from epidemic diseases, and the greater accuracy of diagnosis, as respects carcinomatous affections. We must wait for correct answers to questions of this high import, until the present Registratica Act has been in operation for a series of years. It would not serve a practical purpose to inquire too far back into the earlier records of cancer mortality, which for self-evident reasons must have been less trustworthy and conclusive than those derived from official registration returns. | It would also be misleading to determine the increase in cancer mortality on the basis of a proportion to the mor- tality from all causes, although under given conditions this method may yield fairly satisfactory results. The extract from the work by Walshe is merely included as evidence that even seventy years ago the question of cancer increase was receiving critical attention and that the same con- clusion was then advanced as now: that the increase was more apparent than real and due primarily to improved diagnosis. *These three proportional numbers are taken from a table calculated by Dr. Farr, and given at page 577 of his "Vital Statistics." fThe absolute number of deaths from cancer registered in the metropolis during this period was 470, bring- ing cancer from a position of almost no importance to that of a predominating cause of death. JAmong the earliest mortality statistics by causes are the returns for the Jews of the Vienna Ghetto, 1648-69, discussed by Dr. Schwarz in the periodical on the Demography and Statistics of the Jews, April, 1910. According to this writer, out of 883 medically or otherwise certified causes of death among the Jews of Vienna during the period 1648-6S, only one death was due to cancer. (See note on page 23.) THE MORTALITY FROM CANCER Causes of Local Variations It is a practical certainty, however, that this argument can be carried too far, A point must be reached, sooner or later, where the margin of error is reduced to relatively unimportant proportions. A definite maximum figure in cancer mortality, however, can not be said to exist. There is an enormous range in cancer frequency from the almost complete absence of the disease to its being one of the principal causes of death in adult life. A maximum point of normal fre- quency must, of course, be reached in time, particularly in the case of long-settled and densely populated countries. Such a maximum rate, however, would not by any means indicate errors or defects in low prevailing rates for other countries. "Cancer," like "fevers," is an indefi- nite term and comprehends affections due probably to the same causes or conditioning circumstances, but with fundamentally different results as regards the organs or parts of the body affected. An excessive cancer death rate in one country may be largely due to a high mortality from cancer of the stomach among males; in another country, the excess in the cancer death rate may be chiefly due to a high degree of frequency of cancer of the uterus or of the female breast. Certain forms of cancer prevail in some regions of the globe which are practically un- known in others : the so-called Kangri cancer of Kashmir, for illustration, is not met with among civilized mankind.* Cancer of the cheek, caused apparently by slow irritation following the chewing of the betel nut by the women of India, is very rare among Europeans. It is therefore an entirely safe conclusion that gastric cancers or uterine cancers, which are excessively common among civilized races, may be actually very rare among, but not completely absent from, native races, existing under fundamentally different conditions of life. The more thoroughly the geographical distribution of cancer is studied, particularly with regard to the local incidence, according to organs and parts of the body affected, the more definite is the conclusion that observed variations in cancer fre- quency are real and not apparent; that they are the evidence of a greater or less susceptibility to various forms of malignant disease and not primarily or exclusively the result of incompetence, carelessness or indifference in medical diagnosis. The Argument by King and Newsholme One of the most important contributions to the question of cancer in- crease is the classical essay on "The Alleged Increase of Cancer," by King and Newsholme, originally read before the Royal Society on May 4, 1893. The paper includes an interesting review of the earlier statistics of cancer in England and Wales and the observations of the Registrar-General on the apparent increase in the mortality rate. The experience data of certain insurance companies were utilized, but only to rather limited advantage. The main reliance of the authors was upon statistics of the city of Frankfurt a/M., Germany, which differentiate certain forms of accessible and inaccessible cancers, it being stated that "under accessible cancers we have included only four headings : tongue, mammae, uterus *For a descriptive account of Kangri cancer, by Ernest F. Neve, M. D., with illustrations, see The British MedicalJournal, September 3, 1910, 30 THE INCREASE IN CANCER and vagina, all of which are capable of careful and exact diagnosis."* This point of view, however, must be seriously questioned; for it is quite doubtful whether all uterine or even vaginal cancers can be accurately diagnosed as such without an exploratory operation or a microscopical examination of the diseased parts. Under "inaccessible" cancers, the authors, on the basis of the Frankfurt data, considered all other forms than those mentioned. Now, obviously, a fair proportion of deaths from cancer are those of the skin, other parts of the mouth than the tongue, and other external parts of the body, which being included among the inaccessible cancers must, to a certain extent at least, have affected the accuracy of the conclusions. A more useful classification of accessible, intermediate and inaccessible cancers, is given by Bash- ford in the Report of the Imperial Cancer Research Fund on "The Statistical Investigation of Cancer," previously referred to.f Attention was drawn to the fact that the cancer death rate of Frankfurt was quite considerably in excess of the corresponding rate of the United King- dom, but no satisfactory explanation could be offered for this difference except the extremely careful death certification in use in this German city. To compare the rate of a country with that of a city is in it- self quite apt to be misleading. For the five-year period ending with 1910, the cancer death rate for London, combining both sexes, was 111.0, against a corresponding cancer death rate of 96.2 for Frank- furt. The difference on the basis of a more correct comparison was therefore indicative of a higher cancer prevalence in the capital city of England when compared with one of the large cities of Germany. The main contention of Messrs. King and Newsholme, on the basis of the Frankfurt data, was that the apparent increase in cancer was practically limited to the occurrence of this disease in the internal or inaccessible organs, or, in their own words: "Taking a general view of the Frankfurt figures the one result of surpassing importance to be derived from them is that in those parts of the body in which cancer is easily accessible and detected there has been no increase in the mortality from it between 1860 and 1889," Recent Cancer Statistics of Frankfurt a/M. For reasons unknown, the authors have not considered it necessary to reexamine into the facts during the long intervening period of time. The Frankfurt data are by no means the most useful or conclusive information for a scientific study of cancer statistics; in fact, the classification fails to conform to modern requirements, in that it is not in accordance with the International Classification of Causes of Death, f In view of the *The problem of cancer increase with special reference to the Frankfurt data has recently been discussed by Prof. Walter F. Willcox in an address before the American Public Health Association at the Jack- sonville meeting, 1914. The paper presents the results of an original study of the Frankfurt statistics since 1865, but unfortunately the King-Newsholme classification of internal and external cancers is retained, so that the conclusions can not be considered final. (See also discussion on pages 83-90.) tThe title of this publication is "Scientific Reports on the Investigations of the Imperial Cancer Research Fund," Part 1, Statistical Investigation of Cancer, London, 1905. (See Table 8, Appendix A.) IThe conclusiveness of the Frankfurt data is very much exaggerated. The population of Frankfurt is only 438,000 and a considerable proportion are Jews. The city hospitals are made much use of by strangers, and it is not entirely clear whether correction has been made for this factor. In view of the extremely complex nature of the cancer problem the statistics for any given community, however large or however extended in point of time, are only of limited utility. They are useful, but not finally conclusive. 31 THE MORTALITY FROM CANCER value frequently attached to the conclusions on the basis of the Frank- furt data, the more recent statistics have been brought together, as given in the official reports made annually by the Frankfurt Medical Society. The follo^^dng table exhibits the comparative mortality by organs and parts, for two periods, ending respectively with 1909 and 1913. Mortality from Cancer in Frankfurt a/M., by Organs and Parts of the Body according to Sex, 1906-1909 and 1910-1913 MALES Organ or Part Skin Digestive organs Respiratory organs Urinary organs Generative organs Other carcinoma Sarcoma Other malignant tumors . Deaths from Cancer 1906-09 1910-13 3 470 32 21 6 25 28 23 Total i 608 6 540 23 27 8 29 35 46 714 Rate per 100,000 Population 1906-09 1910-13 0.4 68.5 4.7 3.1 0.9 3.6 4.1 3.3 88.6 98.2 Per Cent, of Increase 0.8 4-100.0 74.2 -f8.3 3.2 —31 9 3.7 + 19.4 1.1 + 22.2 4.0 + 11.1 4.8 + 17.1 6.4 + 93.9 + 10.8 FEMALES Organ or Part Skin Digestive organs Respiratory organs Urinary organs Generative organs Other carcinoma Sarcoma Other malignant tumors. Total Deaths from Cancer 1906-09 1910-13 12 447 25 5 244 76 26 24 859 500 17 20 288 80 30 48 991 Rate per 100,000 Population 1906-09 1910-13 1.5 54.4 3.0 0.6 29.7 9.2 3.2 2.9 0.9 57.2 1.9 2.3 33.0 9.2 3.4 5.6 104.5 113.5 Per Cent, of Increase -^0.0 + 5.1 —36.7 + 283.3 + 11.1 0.0 + 6.3 +93.1 + 8.6 Conclusions Opposed to Experience This table is exceptionally instructive, in that the general cancer death rate is shown to have increased during the last period, compared with the first, from 88.6 to 98.2 for males and from^ 104.5 to 113.5 for females. Accepting the view that death certification in Frankfurt^ is considered satisfactory and complete the conclusion would seem in- controvertible that there has been an actual as well as a relative increase in cancer mortality in Frankfurt of 10.8 per cent, for males and 8.6 per cent, for females. Considered by organs and parts, on the basis of a rather unsatisfactory classification, it appears that among males the mortality from cancer increased in every group excepting cancers of the respiratory organs, which are relatively 32 THE INCREASE IN CANCER unimportant. Cancer of the skin doubled in frequency; cancer of the digestive organs increased 8.3 per cent., but the earher rate for this group is distinctly excessive, and a maximum figure has possibly been reached. Among females, cancer of the respiratory organs and of the sldn decreased, but all the other groups increased, including cancer of the generative organs, which, according to Messrs. King and News- holme, were among those classified as accessible. The most recent data for Frankfurt, therefore, do not confirm the earlier conclusion that the increase in cancer was only apparent and not real.* An important discussion as regards the alleged increase in cancer on the basis of German insurance experience occurs in the Proceedings of the German Society for Insurance Science, f In this discussion it is emphatically denied by the Medical Director of the Gotha that the observed increase in cancer mortality was the result of improved diagnosis. He points out that even in the '80s and '90s cancer diag- nosis was sufficiently well developed to provide reasonable accuracy in death certification. The same authority concludes that in only nine per cent, of the mortality from cancer in the company's experience was there a previous record of cancer in the family history. Increase in Cancer, by Organs and Parts There are some additional data extant regarding this aspect of the cancer problem, which may be briefly referred to here. For England and Wales the data are available for the two periods 1897-1900 and 1901-10. The mortality of males from cancer of accessible organs in- creased 27.4 per cent., against 22.2 per cent, for the inaccessible organs and the undefined group decreased 24.0 per cent. Among females the mortality from cancer of accessible organs increased 16.7 per cent., or, including cancer of the uterus, 9.9 per cent.; cancer of the inaccessible organs increased 16.6 per cent., and cancer of the undefined group de- creased 32.1 per cent. The English statistics of recent years are, there- fore, also in flat contradiction of the conclusions based upon the earlier Frankfurt data. The details for England and Wales, according to organs and sex, are given in Tables 10 to 13, inclusive, of Appendix G.| For Bavaria the data are available for the two periods 1905-07 and 1905-10. Among males, cancer of the accessible organs increased 25.5 per cent.; of the inaccessible organs, 5.2 per cent.; and of the undefined group, 4.4 per cent. Among females, cancer of the accessible organs increased 15.6 per cent., or, including cancer of the uterus, 8.3 per cent.: cancer of the inaccessible organs increased 4.8 per cent., and cancer of the undefined group, 4.3 per cent. The statistics for Bavaria, there- fore, also confirm the conclusion that the observed increase in the cancer death rate represents a real increase, being found to have occurred chiefly •See in this connection reference to a recent discussion of the Frankfurt data on page 46. fZeitschrift fiir die gesamte Versicherungs-Wissenschaft, Berlin, 1912, Vol. xii, p. 309. tWhen comparing the cancer mortality of England and Wales for 1901-10 with 1911-12, it appears that the male cancer death rate has increased 16.9 per cent.; the increase in the rate for accessible organs is 25 per cent.; for iiiaca;ssible organs, 18.1 per cent.; the undefined group shows a decrease of 5.1 per cent. The female cancer death rate has increased 7.5 per cent.; the rate has increased 12.1 per cent, for accessible organs, exclud- ing the uterus, and 14.4 per cent, for inaccessible organs. Cancer of the uterus shows a decrease of 8.9 per cent., and the undefined group a decrease of 3.1 per cent. 33 THE MORTALITY FROM CANCER in the group of cancers conveniently accessible for the purposes of medical and surgical diagnosis. Of course, the variations in the rate of increase of the different forms of cancer are of considerable importance ; but they do not require discussion, being fully disclosed by the tables giving the necessary details. The data for Bavaria are given in Tables 93 to 95 of Appendix G.* The conclusions of Messrs. King and Newsholme were strongly opposed in an address on the "Increase in Cancer," delivered by J. F. Payne on October 12, 1898, before the Hunterian Society. In 1899 the subject was further discussed by J. H. Richardson, F. F, A., in an address before the Insurance Institute of New Zealand on "Phthisis and Cancer," and in 1901, before the Institute of Actuaries, London, Richard Teece, actuary of the Australian Mutual Provident Society, reconsidered the then available material, which was followed by a discussion participated in by Dr. Payne, Dr. Glover Lyon, Dr. H. Fox, Mr. George King and Dr. Arthur Newsholme. The discussion did not prove or disprove successfully either contention, largely because the new material re- quired for consideration was not then available for critical analysis. Statistical Inquiries of the Imperial Cancer Research Fund The next important contribution to the statistical study of the prob- lem of cancer increase was a brief report published by the authority of the Executive Committee of the Imperial Cancer Research Fund in 1905. The joint authors of this report were Dr. E. F. Bashford and Dr. J. A. Murray. The conclusions, however, had no doubt been con- sidered by the members of the Sub-Committee of the Society, including Dr. J. F. Tatham, then Registrar-General, and Dr. Arthur Newsholme. The report includes a brief discussion of the inherent limitations of statistical investigations of cancer, of the fallacies apparently inherent in a cancer census, the importance of age incidence in cancer, the bearing of the provisional results of the statistical study of the Fund upon the question of the alleged increase of cancer, and, finally, important obser- vations on the frequency with which microscopical examinations, in the cases of carcinoma and sarcoma, f were made in operative cases and on post-mortem cases, indicating the presence of conditions leading to the wrong diagnosis of malignant new growths. The report contains many observations and conclusions to which, from a statistical point of view, it is necessary to take exception. The report of 1905 has not been followed by any further publications of a similar nature by the Imperial Cancer Research Fund. An extended critical review of the report would make a useful contribution to the cancer problem. { •Bericht ueber das Bayerisches Gesundheitswesen, Munchen, 1912. tThe following concise definitions of carcinoma and sarcoma are from the second edition of Gould and Pyle's Pocket Cyclopedia of Medicine and Surgery, Philadelphia, 1914. "Carcinoma. — A malignant tumor characterized by a network of connective tissue the areolas of which are filled with cell masses resembling epithelial cells." "Sarcoma. — A connective-tissue tumor in which the cells so predominate in number, and often in size, that the intercellular substance becomes a secondary element. Sarcomata are maglignant tumors and appear at an earlier age than carcinoma. They are made up of embryonal connective tissue and are of three varieties: the round-cell, the spindle-cell, and the giant-cell sarcoma. They may exist alone or in combination with other tumors." tSee in this connection The Lancet, February 7, 1914, and April 11, 1914, containing correspondence on the Accuracy of American Vital Statistics, with special reference to cancer. 34 THE INCREASE IN CANCER Utility of a Cancer Census It may be laid down as a first prerequisite of statistical research that the data relied upon shall be sufficient in extent and period of time to provide a basis for accurate and safe conclusions. The report of the Imperial Cancer Research Fund considers a large variety of subjects, all of more or less importance in their relation to the statistical aspects of the cancer problem. The practical utility of a cancer census is con- sidered at some length, but the conclusions arrived at are decidedly adverse to such investigations. It is maintained that a cancer census depends, first, upon the adequate identification of all cancer cases and secondly, upon the existence of a standard population in which these cases arise. Neither of these requirements can be met in any statistical inquiry of this kind. Under no conceivable circumstances could any scientific investigation determine the total existing amount of cancer- ous affections in the entire population, from cases in the very initial stages to cases in the most advanced. As a practical compromise all such investigations are properly limited to the cancer cases under medical ob- servation, as being fully sufficient for the purpose of study and compari- son. Dr. Bashford in this connection insists upon a standard population; but a standard population is simply a statistical assumption and an expedient to facilitate the comparison of otherwise varying population factors. A population of any normal country may be assumed as a standard, provided the populations of the other countries are reduced to the same basis of age and sex distribution.* The authors of the report use the term "actuarial statistics," which is also misleading. Actuarial statistics, properly speaking, are those of life insurance companies, having to do with mortality experience and valuation methods, or, in other words, the practical application of the science of life contingencies to the business requirements of insurance institutions. Such statistics are not necessary or useful in connection with cancer mortality investigations, although it is entirely proper and, in fact, highly desirable that actuarial methods should, under given con- ditions, be applied to the statistical consideration of certain special phases of the cancer problem. Dr. Bashford, in the report referred to, maintains that "there is nothing in the statistical investigations of the Imperial Cancer Re- search Fund which points to an actual increase in the death rate from cancer." Such an important and far-reaching conclusion should be substantiated by indisputable and incontrovertible, as well as a sufficient amount of, statistical evidence. No such evidence is presented in the report for 1905. The further conclusion that "it is not possible to determine statistically whether cancer is really increasing as the increase in the recorded cases would imply" is also not sustained by the facts available, nor justified when conservative and trustworthy methods are employed in the statistical study of the cancer problem. The present work is intended to meet this requirement and to furnish the necessary statistical evidence for a scientific study of the cancer problem from the statistical point of view. *A cancer census is being undertaken by the State Medical Society of Wisconsin, but unfortunately upon the basis of a blank which is not likely to jneld all of the required information. A more elaborate cancer census is contemplated by the Michigan State Board of Health. 35 THE MORTALITY FROM CANCER Cancer among Primitive Races There are many other conclusions and observations in the Report of the Imperial Cancer Research Fund on the statistical investigation of cancer which do not stand the test of impartial consideration. The argument, for illustration, that "the relative frequency of cancer in native races cannot yet be even approximately estimated" is not sustained by the many investigations which have been made by quali- fied medical observers, with an extended practice among native races throughout the uncivilized portions of the world. * It is self-evident that the information regarding cancer frequency in native races can not be considered of equal value with the returns for civilized countries ; but it is necessary to refer only to such a painstaking study as has been made of the spread of cancer among the descendants of hberated Africans or Creoles by Dr. W. Renner, published in the annual report of the Sierra Leone Medical Department for the year ending December 31, 1909, to contradict the statement that the relative fre- quency of cancer among native races "cannot yet be even approxi- mately estimated."! Cancer Census of Baden The practical utility of cancer census investigations is unquestionably rather limited; but qualified opinion, certainly on the continent of Europe, seems to faA'or inquiries of this kind. The Cancer Census of Baden and Hungarj^ in particular, may be referred to as useful and instructive studies, the results of which are fully commensurate with the labor and expense necessary to collect the facts. The value of such investigations is enhanced by the intelligent correlation of cancer mor- tality data. In any event, so important a question as the value of a cancer census can be settled only by means of a thoroughly critical and qualified analysis of the facts, which, it may be said, has not been made, or at least has not thus far been published, by the Imperial Cancer Re- search Fund. The cancer census of Baden, published in 1910, is an exceptionally valuable illustration of the methods of statistical inquiry to be followed in local cancer research. The investigation includes a study of the geographical distribution of cancer according to age and sex throughout the Grand Duchy of Baden, the frequency of deaths from sarcoma, the influence of season, occupation, etc., and the geographical distribution by small subdivisions of territory, such as in this country would correspond to townships. This analysis of the mortality covers the period 1883-1907, and the variations in the rate by single years, are illustrated by maps and diagrams of exceptional clearness. The argu- ment is advanced that the results of such an inquiry would be materi- ally improved if the notification of cancer cases were made compulsory. The occasional disparity in the number of cases reported to the cancer committee, in contrast with the observed mortality, is explained on the *For much interesting and useful information regarding cancer among native races, see three reports pub- lished by the Colonial OfiBce containing the correspondence on the Imperial Cancer Research Scheme, London, (1905, 1906, 1908) and also the discussion on "The Ethnological Distribution of Cancer," by E. F. Bashford, in the Third Scientific Report of the Imperial Cancer Research Fund, London, 1908. There are numerous special reports on cancer occurrence among primitive races in the volumes of the German Journal for Cancer Research (Zeitschrift fur Krebsforschung, 1903-13). tSee in this connection the discourse on the geographical distribution of appendicitis by R. W. Murray in The Lancet, July 25, 1914. 36 THE INCREASE IN CANCER ground that in many cases the full cooperation of reporting physicians was not obtained. Statistical Problems of Erroneous Diagnosis A strictly scientific study of cancer statistics is unquestionably a dif- ficult undertaking. The problems involved are not only statistical and mathematical, but the medical, anthropological and sociological difficul- ties are even more complex. As previously pointed out, in England and Wales during the last fourteen years the accessible cancers have increased more rapidly than the inaccessible; and although cancer of the breast is one of the most easily recognized forms, the death rate of this group of cancers is distinctly higher now than in former years.* No conclusive answer has been made to the question as regards the diseases or causes to which deaths from cancer may have been erroneously assigned on the basis of a mistaken diagnosis or an unscientific method of classification. There is no evidence that the disease groups to which cancer might erroneously have been assigned have materially decreased, if at all, coincident with the gradual rise in the cancer death rate. Using the English data, as perhaps the most conclusive, it may first be said that there can be only com- paratively few groups of diseases or causes to which cancer deaths could be erroneously assigned; for obviously this could not be the case with zymotic diseases and accidents, pregnancy, infantile diarrhoea, diseases of the nervous, circulatory or respiratory system. Some of these causes, in fact, have increased in recent years; and this is also true of diseases of the urinary system. The first suggestive group more or less related to cancer is that of gastritis, gastric ulcer and other diseases of the stomach; but the death rate of this group, in the English experi- ence, has actually increased from 14.7 per 100,000 of population in 1891 to 15.8 in 1910. The mortality from ulceration of the intestines has also increased from 1.2 per 100,000 of population to 2.4; diseases of the liver and gall-bladder, excluding cirrhosis, how^ever, decreased from 16.3 per 100,000 of population to 5.3; but there has also been a corre- sponding decrease in cirrhosis of the liver, so that, in other words, all diseases of the liver are apparently decreasing. Yet this is a group which no doubt under an imperfect classification or in consequence of an erroneous diagnosis includes some deaths from cancer, due to the fact that the liver is occasionally the primary seat of the disease. Non-malignant diseases of the ovaries and the uterus have decreased from 4.0 to 2.6; but since cancer of the uterus in England is rather stationary, this decrease is not of practical importance. Ulcers, which are an ill-defined group and most likely to include imperfectly diag- nosed deaths from cancer, decreased from 1.8 to 1.3; in other words, the diminished mortality was actually and relatively of no practical importance. Tumors (not specified) diminished from a very low mortality of 0.5 to 0.2; and abscesses, also an insignificant mortality factor, diminished from 1.8 to 0.7. Granting that the decrease in some of these causes sustains the conclusion that the diminu- tion is the result of more accurate diagnosis or classification of *In the five years 1903-07, the mortality from cancer of the female breast per 100,000 of population in England and Wales was 17.1; during the period 1908-12, the rate increased to 18.6. In 191'2 it had further increased to 19.8. 37 THE MORTALITY FROM CANCER cancer, the combined effect on the general cancer death rate would not be of much practical significance. Deaths in old age, which might hide a considerable proportion of deaths from cancer, which is so exceptionally a disease of advanced adult life, increased from 94.2 to 95.7. Ill-defined and not-specified causes diminished in frequency from 9.3 to 2.3, or 7.0 per 100,000 of population, during the twenty- year period under review, which, of course, is significant; but the decrease since 1901, or during the last decade, has been only 2.2, whereas there has been an increase of 15.0 per 100,000 of population in the cancer death rate during the intervening period of time. The theory of an improved diagnosis or a transfer of deaths to cancer from other groups of diseases or causes is, therefore, not tenable as a general proposition or as an explanation of the recorded increase in the cancer death rate of England and Wales during the last twenty years.* With- out enlarging upon this discussion, it may be said that deaths from ulcer of the stomach, biliary calculi, and calculi of the urinary tract, have all been increasing, and some of these rapidly so, in the registration area of the United States during the period 1900-12, and to this extent the conclusions based upon other data are confirmed. It is not the purpose of this investigation to enlarge upon the statistical aspects of any particular phase of the cancer problem, for in view of the considerable amount of material brought together, such an ex- tended discussion of the facts would be impracticable. The tabular analysis is made available to facilitate an extended statistical study of the cancer problem, but certain phases of the same are taken note of so far as the facts may require to be emphasized or explained. Conclusive Evidence of Cancer Increase In the foregoing discussion it has been implied that cancer is on the increase practically throughout the civilized world. It is main- tained that this increase is not apparent, but real; in other words, not the result of improved diagnosis or more scientific classification or of a changed age distribution. Combining the returns for the United Kingdom, Norway, Holland, Prussia, Baden, Switzerland, Austria, the cities of Denmark, the Commonwealth of Australia and the Dominion of New Zealand, it appears that these countries in 1881 had an aggregate population of 98,380,000 and 44,047 deaths from cancer, equivalent to a rate of 44.8 per 100,000 of population; by 1891 the rate had increased to 59.6, by 1901 to 76.3, and by 1911 to 90.4. Thus, during thirty years the cancer death rate in these countries, which are typical of the civilized portion of the world, has more than doubled, or, to be exact, the rate for 1911 was 101.8 per cent, in excess of the rate prevailing in 1881. In 1912 these countries had a population of 136,892,000 and 125,832 deaths from cancer, equiva- lent to a rate of 91.9. If the cancer death rate of 1881, previously given as 44.8, had prevailed in 1912, there would have been only 61,323 deaths from cancer instead of nearly 126,000; if the cancer death rate of 1912, previously given as 91.9, had prevailed in 1881, the actual number of *The increase in the cancer death rate of England and Wales has continued, and the most recent data are as follows: the average, standardized, cancer death rate for the period 190(j-10 was 88.2 per 100,000 of population, increasing to 91.4 during 1911, to 93.7 during 1912 and to 97,2 during 1913 THE INCREASE IN CANCER deaths from cancer would have been 90,411 instead of 44,047. Is it a tenable proposition, in view of these facts of observed experience, that the recorded increase in the cancer death rate is only apparent and not real? Is it conceivable that in 1881 in these typical civilized countries of the world 46,364 deaths from cancer were erroneously diagnosed or mistakenly classified under some other terms? No one familiar with the attained status of medical and surgical science in 1881 will be likely to maintain such a preposterous conclusion. Another illustration is the experience of the State of Massachusetts. In 1871 the recorded cancer death rate was 36.9 per 100,000 of popula- tion; by 1881 the rate had increased to 52.3; by 1891 to 60.9; by 1901 to 73.1, and by 1911 to 92.6. In 1871 the population of the State was 1,494,000 and the number of deaths from cancer was 551. If the rate for 1911, previously given as 92.6, had prevailed in 1871, there would have been 1,383 deaths from cancer instead of the 551 actually returned. The State of Massachusetts established the registration of vital statistics in 1842, or five years after the establishment of registration in England and Wales. Boston has for many years been one of the medical centers not only of the United States, but of the world. There are no reasons for believing that medical diagnosis was so crude or imperfectly devel- oped in 1871 that one out of every two deaths from cancer should have been erroneously diagnosed or wrongfully classified under some other disease. Nor is there any evidence to substantiate the point of view that the age distribution of Massachusetts has undergone such pro- found changes as to account for the higher frequency of cancer at the present time. In 1880 the proportion of population ages 65 and over in Massachusetts was 5.4 per cent.; in 1900 it was 5.1 per cent.; in 1910 it was 5.2 per cent. From a practical point of view in statistical anal- ysis, these changes in the age distribution can have been of only slight effect on the cancer death rate. Cancer Increase Throughout the World Limiting the present observations to the changes in the cancer death rate during the last decade, divided into two periods of five years each, and to the principal countries of the world, including the United States, for all of which approximately trustworthy registration returns are available, the facts, briefly summarized, are as follows : For all the countries considered, with an aggregate population of 365,083,000 in 1910, the cancer death rate increased from 67.7 per 100,000 of population during the first five years to 74.3 during the last. The rate of increase was therefore equiva- lent to 9.7 per cent. The details of this comparison are given in Table 2, iVppendix G, on Cancer Statistics of Foreign Countries. The percent- age of increase was 28.5 for Cuba, 23.4 for Uruguay, 17.6 for Scotland, 17.2 for Ontario, 16.8 for Brazil, 15.2 for Italy, 15.0 for Ireland, 14.8 for Japan, 12.5 for the Australian Commonwealth, 12.2 for Spain, 11.5 for Hungary, 11 .5 for France, 10.2 for British Columbia. Most of these countries have cancer death rates below the average for all of the coun- tries combined. In the countries with a higher cancer death rate, the rate of increase, for self-evident reasons, has been less. A point must be reached beyond which no single cause or group of causes of death can 39 THE MORTALITY FROM CANCER persistently increase. In the German Empire the cancer death rate increased 8.5 per cent.; in England and Wales, 8.4 per cent.; in Jamaica, 7.7 per cent.; in New Zealand, 7.0 per cent.; in the United States, 6.9 per cent.; in Danish cities, 6.4 per cent.; in Holland, 5.8 per cent.; in Austria, 4.8 per cent. ; in Sweden, 2.2 per cent. ; in Norway, 1 .8 per cent. ; in the Argentine Republic, 1 .7 percent. ; in Switzerland the rate diminished 1.1 per cent. The rate for Switzerland, however, during the period 1901-05 was 128.3, or nearly double the average for all the countries combined; during the period 1906-10 the rate decreased to 125.9. Next to Switzerland, the cancer mortality is decidedly excessive in the King- dom of Holland, where in 1906-10 it attained to a rate of 103.5 per 100,- 000 of population. A cancer census of Holland was published as an ap- pendix to the cancer census of Germany in 1902. In 1911 a special report was issued by the Bureau of Municipal Statistics of Amsterdam, on the mortality from cancer during the period 1862-1902, including some es- pecially interesting data on the comparative frequency of cancer among Jews and Christians. An extremely valuable portion of this report is a table showing separately the deaths from cancer and sarcoma during the period 1897-1902, by sex and single years of life. In 1911 the same bureau issued a special volume of international mortality statistics, in- cluding cancer, which, however, unfortunately contains a number of clerical errors, and in which no distinction is made of sex, age, and organs and parts. When the cancer death rates are limited to large cities, they are naturally somewhat higher, partly on account of special opportunities for hospital treatment. This probably explains the relatively higher rates for the cities of France and Denmark and the Argentine Republic (limited to the Province and City of Buenos Aires). These conclusions regarding the increase in the mortality from cancer are fully confirmed by the details of the statistical analysis of the different countries and cities of the world, in another portion of this work.* The evidence is so convincing that it may safely be maintained that no other statistical conclusion in medicine is so concisely and incontro- vertibly established as this; in any event, no satisfactory evidence is available to successfully contradict this conclusion at the present time. If all of this evidence, however, is inconclusive and worthless, then no alternative remains but to discredit the statistical returns of every coun- try in the world with regard to any single disease or group of diseases, although the returns are accepted as approximately accurate with regard to every other important cause of death. More than this, it would seem to follow as a logical conclusion that medicine has not made the progress that it is generally assumed to have made during the last two generations, and that, in fact, even now a colossal amount of public ignorance exists regarding the most obvious evidences of malignant and destructive new growths. There is, however, no substantial ground for such far-reaching *An important factor tending to reduce the cancer death rate is the increasing practice of surgical operations for malignant disease. The evidence is overwhelming that a considerable number of deaths from cancer are prevented by er.rly surgical operations, and that a large number of deaths from malignant disease are in any event postponed by this means. Deaths must result to an increasing extent from other causes than cancer in the case of cancer patients successfully operated upon in conformity to modern surgical practice. Data are not available to determine the exact effect of surgery upon the cancer death rate, but it is safe to assume that but for the increasing extent of surgical interference the present cancer death rate would be perceptibly higher than is actually the case. 40 THE INCREASE IN CANCER conclusions ; on the contrary, the evidence presented will stand the most critical analysis in support of the theory that for practical purposes the law of large numbers applies in the present case as in many other studies of collective phenomena and that the conclusions derived there- from may be accepted with entire confidence and the reasonable certainty that they will not be materially modified or changed in important par- ticulars by subsequent investigations.* Misleading Statistical Observations It is not practicable on this occasion to further discuss the contro- versial aspects of the question whether cancer is on the increase or not; the burden of 'proof rests with those who maintain the negative point of view. Qualified opinion, generally speaking, on medical or surgical grounds, favors the conviction that cancer is actually and relatively on the increase among civilized mankind. The evidence brought together by R. W. Williams regarding the increase of cancer and its concomitants is quite conclusive. A considerable amount of additional evidence is contained in the Proceedings of the German Society for Cancer Research. Reference, however, may properly be made to an article "On the Supposed Increase of Cancer," in the issue of the Journal of the American Medical Association, dated June 24, 1899, by E. Andrews, M. D., as an illus- tration of the misapplication of the statistical method to research work of this kind. Correct statistical analysis presents the same practical difficulties as correct clinical or anatomical diagnosis. The article referred to adds nothing of value to cancer research and tends only to confuse the question at issue. In a similar case in the Journal of the American Medical Association for November 10, 1906, Dr. Robert Reyburn quotes Dr. Roswell Park to the effect that "if the present increase of cancer in the United States continues from 1899 to 1909, there will be more deaths from cancer than from consumption, smallpox and typhoid fever combined." This statement on its face is a self-evident absurdity. In an address delivered before a general meeting of the Sixteenth International Medical Congress, held in Budapest, 1909, and reprinted in the New York Medical Record for September 4th of that year. Dr. Bashford commits himself to the conclusion that he very much questions "if those persons who have made exaggerated statements to the effect that the recorded increase in cancer represents a true and relatively increased liability to it, have any excuse whatsoever for enhancing the reasonable anxiety of the lay public." These observations are also applicable to a very recent treatise on "The Cancer Problem," by Dr. William Seaman Bainbridge, which includes a section on "Statistical Considerations." It is difficult to under- stand what practical value such observations can serve in the medical study of the cancer problem, being simply a heterogeneous collection of mere figures derived from miscellaneous sources. It is not correct, for illustration, to say that "the investigations of the Imperial Cancer Research Fund have shown that the disease occurs among all races of mankind." The three official reports published by Parliament regarding *There is an extended statistical discussion of the cancer problem in the appendix of the annual report of the State Board of Health of Massachusetts for 1900, but the methods of statistical analysis are inadequate to the purpose, and the results of the investigation are, therefore, in the main quite inconclusive. 41 TEE MORTALITY FROM CANCER cancer in the British possessions throughout the world do not include all of the world's races and tribes; nor were the investigations made with the required degree of thoroughness and completeness. It is also not correct to 'say that in the United States "there are no reliable statis- tics concerning either the relative frequency of cancer in the past or its relative frequency in the different states, in the different towns, or in towns as compared with country districts." This conclusion is merely a repetition of the views of the Director of the Imperial Cancer Research Fund, who, as shown by his writings, has not the necessary knowledge of. American vital statistics. The present work is an emphatic contradiction of the view that American cancer mortality statistics, past and present, are not in a general way strictly comparable with the corresponding data for other civilized countries. It is an error to maintain that the cancer death rate increases from 35 to the end of life. * There are trustworthy data to sustain the view that very late in life the cancer death rate is lower than in earlier years. Finally, among other statistical errors, the statement is made that a comparison of the white and the colored cancer death rate is not possible, because, it is claimed, "the South has hitherto been entirely unrepresented by reliable state registration." The required data are not necessarily derived from the states as a whole, but for the South from large and representative cities, and for that reason are at least approximately trustworthy with regard to the negro element. The Truth of the Cancer Problem Provided the arguments in favor of the theory that cancer is on the increase are based upon trustworthy official mortality statistics, the question at issue is not whether the anxiety of the public is aroused, but whether the public may rightfully be prevented from knowing the truth. From a public point of view it is perhaps immaterial whether cancer is actually or only apparently on the increase or not, but it is of the utmost importance to the people to know whether cancer is in truth more common at the present time than is generally supposed to be the case. If because of erroneous diagnosis or inaccurate classification the cancer death rate has been understated in the past, it is a public duty on the part of all familiar with the facts to make the truth known and to establish the menace of cancer beyond a doubt. Only by means of an accurate perception of the extreme seriousness of the cancer question in adult life can the necessity for the earliest possible recognition and recourse to qualified treatment be brought home to the laity, now largely misled by superficial reasoning and hair-splitting arguments on so important a question from a scientific point of view as to whether cancer is relatively more common among civilized mankind than has generally been supposed *M0RTALITT FROM CanCER IN ENGLAND AND WaLES, BY AqE AND Sex, 1901-1910 Rate per 100,000 Population Ages Persons Males Females UnderSS 5.5 4.9 6.1 36-44 63.7 41.3 84.6 45-54 194.8 154.8 231.9 66-64 417.0 390.2 440.8 66-74 666.2 667.6 665.1 75-84 795.7 794.1 796.8 85 and over 733.7 7Si.9 738.7 AUAges 90.4 77.3 102.7 42 THE INCREASE IN CANCER to be the case. From a lay point of view it is not a question whether the observed increase in the rate is real or unreal ; the question is as to what proportion of mortality is in all probability caused by cancer in adult life at the present time ; and no one familiar with the facts can deny that the public is ignorant or woefully misinformed as to the truth regarding the seriousness of the cancer situation considered from this point of view. Dr. James Ewing in an address on "Animal Experimentation and Cancer" published in the Journal of the American Medical Association under date of January 22, 1910, remarks: The weight of evidence to-day points almost conclusively to the opinion that cancer is steadily increasing in frequency in man and domestic animals, and that this increase is likely to become more pronounced. Yet, the most diverse opinions exist regarding the alleged increase in cancer, emanating from the varying character of the evidence assumed by different authorities as valid. Surgeons are practically unanimous in the belief that cancer has been steadily growing in frequency during the last quarter-century, and has been appearing at earlier periods of life. Yet such testimony must be regarded as some- what uncertain and unconvincing. This is a conservative statement by one who properly takes rank as one of the foremost American pathologists engaged in cancer research in America to-day. It is largely on this ground that it has seemed advisable to bring together the statistical facts regarding cancer as a world menace, and the data made available should prove useful even to the pathologist in the furtherance of specialized eflPorts in cancer research. Useless Controversies In the Fourth Scientific Report of the Imperial Cancer Research Fund, issued in 1911, according to The British Medical Journal, of November 11th of that year, Dr. Bashford reverts again to the increase of cancer, in the statement that, with reference to British statistics, for the first time, it is fully demonstrated that it is erroneous to make statements of a dis- quieting nature about the increase of cancer in general. While it is evident that several X)f the differences brought out by the figures can be explained by more accurate diagnosis and by allocation of the seat of the disease from the secondary to the primary situations, as illustrated, for example, by the relation revealed between cancer of the liver and gall bladder, and the alimentary tract, this may not account fully for certain other features. In particular, the increased incidence of cancer recorded for the mamma in women and the tongue in men, require further study and elucidation. In this statement it is conceded that cancer of certain organs and parts of the body is obviously on the increase in England and Wales. No one qualified to discuss the statistical aspects of the cancer problem has maintained that all forms of cancer are uniformly on the increase or to an equal degree. The rise in the general death rate from cancer may prop- erly be referred to as an evidence of cancer increase, without an elabora- tion of the details regarding cancer of certain organs and parts of the body. For strictly scientific and medical purposes, it, no doubt, is more advantageous to discuss the separate aspects of the cancer problem, just as this same conclusion applies to fevers or tubercular diseases. No subject can reach scientific perfection except by gradual evolution from broad generalizations to particular points of controversy. It is therefore entirely correct to speak of an increase in the mortality from cancer, even though not all forms of cancer may be increasing or increasing at the same rate; in fact, there is sufficient evidence to prove that certain forms 43 THE MORTALITY FROM CANCER of cancer in certain parts of the world or particular localities are practi- cally stationary or are actually diminishing. This is a problem of special analysis of cancer data, which, no doubt, is urgently needed, but which has not been forthcoming through the efforts of the Imperial Cancer Research Fund. The subject is again briefly referred to in the Twelfth Annual Report of the Imperial Cancer Research Fund, in which the curious opinion is expressed that "the more general attention to the age factor in official statistics in connection with cancer inquiries has rendered a further statistical report superfluous." Trustworthiness of American Mortality Statistics On account of the pronounced position to which Dr. Bashford has com- mitted himself in this matter, it is necessary to refer to an address delivered in the city of New York, at the Academy of Medicine, in 1912. In this address, as reported in the New York Sun, under the title "Doubts that Cancer is on the Increase," occurs the statement that Dr. Bashford was unable to obtain American cancer mortality statistics with particular reference to age and sex and organs and parts of the body, because such data were non-existent for the United States or any of its component parts. He therefore was reported to have said that "I cannot compre- hend why you citizens of a great state like New York permit this. Doubtless the data exist, but as far as I know they have never been published, and therefore the statistics that mean so much in the study of cancer here are not to be obtained." This statement is in flat con- tradiction to the facts. Since 1900 at least, complete cancer statistics for the registration area of the United States and its component parts have been published annually by the Division of Vital Statistics of the United States Census, with a due regard to age and sex and organs and parts, and they have been available for some of the states and for many of our American cities for a much longer period of years. It is the particular purpose of the present study to present these facts to the public in a convenient form for the required thorough and extended consideration of what may be properly considered one of the foremost medical problems of the present day. Contributory Causes of Death in Cancer It has not been feasible to give even preliminary consideration to the extremely important question of causes of death in cancer patients as disclosed by autopsy records. Obviously concurrent diseases must be relatively common in cancer patients, considering the depressed vitality and diminished disease resistance, at least during the last few months of the cancer patient's life. The only extended study of this phase of the cancer problem appears to have been made by Dr. M. Simmonds, of the General Hospital of Hamburg, "An welchen Komplikationen sterben Krebskranke?" Zeitschrift fiir Krebsforschung, Vol. I, 1903-04, p. 315. This author, on the basis of 760 autopsies, brings out the important fact that a considerable variation is met with in the contributory causes of death, according to the primary seat of the disease. In brief, the investiga- tion by Simmonds shows as follows : In cancer of the lungs, or respiratory diseases, out of 18 cases, 10 were complicated bypneumonia, 4 by cachexia, and 4 by other diseases ; in cancer of the buccal cavity and oesophagus, out THE INCREASE IN CANCER of 117 cases, 47 were complicated by pneumonia, 24 by cachexia, 15 by lung abscess and gangrene, 9 by pleuritis, 6 by pericarditis, 5 by tuberculosis, and 1 1 by other diseases ; in cancer of the stomach, out of 272 cases, 129 were complicated by cachexia, 69 by pneumonia, 19 by peritonitis, 10 by jaundice, 6 by pleuritis, 5 by embolism, 5 by tuber- culosis, and 29 by other diseases; in cancer of the intestines, out of 62 cases, 12 were complicated by cachexia, 11 by pneumonia, 10 by pyelone- phritis and cystitis, 10 by peritonitis, 6 by ileus, and 13 by other diseases; in cancer of the peritoneum, pancreas, liver and gall-bladder, out of 47 cases, 18 were complicated by jaundice, 16 by cachexia, 8 by pneu- monia, and 5 by other diseases; in cancer of the kidneys, bladder and prostate, out of 23 cases, 13 were complicated by cystitis, pyelone- phritis and hydronephrosis, 5 by cachexia, and 5 by other diseases; in cancer of the female generative organs, out of 168 cases, 87 were com- plicated by cystitis, pyelonephritis and hydronephrosis, 28 by ca- chexia, 21 by pneumonia, 16 by peritonitis, and 16 by other diseases; in cancer of the female breast, out of 46 cases, 30 were complicated by cachexia, 9 by pneumonia, and 7 by other diseases; out of 7 cases of cancer of the skin, 3 were complicated by pneumonia, and 4 by other diseases. This analysis is extremely interesting from the practical point of view of general diagnosis. The investigation shows conclu- sively that a wide degree of variation in contributory diseases is met with, according to the organ or part of the body affected with malignant disease. For cachexia, which includes general carcinosis, the proportion of complications was 22 per cent, in cancer of the lungs and respiratory organs, 20 per cent, in cancer of the buccal cavity and oesophagus, 48 per cent, in cancer of the stomach, 20 per cent, in cancer of the intestines, 34 per cent, in cancer of the peritoneum, pancreas, liver and gall-bladder, 22 per cent, in cancer of the kidneys, bladder and prostate, 17 per cent, in cancer of the female generative organs, and 67 per cent, in cancer of the female breast. Inflammation of the lungs, including pneumonia, was a complicating factor in 66 per cent, of cases of cancer of the respiratory organs, in 60 per cent, of cancer of the buccal cavity and oesophagus, in 25 per cent, of cancer of the stomach, in 20 per cent, of cancer of the intestines, in 17 per cent, of cancer of the peritoneum, pancreas, liver and gall-bladder, in 17 per cent, of cancer of the kidneys, bladder and prostate, in 15 per cent, of cancer of the female generative organs, and in 24 per cent, of cancer of the female breast. The relation of the contributory or secondary cause of death to the seat of primary growth is therefore of considerable practical importance.* The investigation by Simmonds shows that in 33 per cent, of the cases there were no serious complications whatever; and in 33 per cent., also, there were direct contributory causes of serious significance, chiefly *Secondary causes of death in cancer are comparatively rarely mentioned in death certificates. Out of 2,531 male deaths from cancer in the Industrial experience of The Prudential, 1909-10, only 108, or 4.3 per cent., of the certificates of death gave secondary or supplementary causes, including 6 from pulmonary tuberculosis, 1 from diabetes (none from alcoholism), 23 from heart and other circulatory diseases, 8 from pneumonia and pulmonary congestion, 1 from appendicitis, 2 from biliary calculi, 24 from acute and chronic nephritis and 10 from dropsy. Out of 5,304 deaths from cancer among females, the certificate of death gave additional information in 225 cases, or 4.2 per cent., including 13 from pulmonary tuberculosis, 5 from diabetes, 1 from alcoholism, 30 from heart and circulatory diseases, 20 from pneumonia and pulmonary con- gestion (none from appendicitis), 17 from biliary calculi, 43 from acute and chronic nephritis, 3 from parturition and 11 from dropsy. 45 TEE MORTALITY FROM CANCER pyelonephritis and cystitis, peritonitis, jaundice; in 30 per cent, there were remote contributory causes, not directly related to the cancerous processes, chiefly pneumonia and pleuritis; and in 4 per cent, there were very remote contributory conditions, chiefly tuberculosis, embolism of the brain, and arteriosclerosis, in no direct relation whatsoever to the death from malignant disease. In other words, summarizing the results of this investigation, in one-third of the cases there were no serious contributory causes of death, and in two-thirds there were such secondary complications, of which about one-half were of diagnostic significance.* Continued Increase in Cancer Frequency In concluding these observations on the general aspects of the question whether cancer is on the increase or not, a brief reference requires to be made to the discussion of the subject before the Cancer Research In- stitute, held at the New York Academy of Medicine, May 15, 1913. On this occasion. Prof. W. F. Willcox, of Ithaca, N. Y., in summarizing the arguments of Messrs. King and Xewsholme, presented to the Royal Society in 1893, and in supporting their conclusions, said: "After an analysis of this and other evidence it may be concluded that probably the larger part and possibly all of the increase in the mortality from cancer is apparent rather than real," and that "Those who doubt this conclusion and hold that most of the increase is real may interpret the evidence as sho-odng that the real increase is not at a geometrical or even an arithmetical rate, but diminishes as the death-rate from cancer rises and that, perhaps, in certain limited areas, like Switzerland and a few cities, it is already approaching its maximum." Prof. Willcox did not present any new data or an original analysis of the available statistical material, but, as pointed out, he merely summarized his own views, based upon those of Messrs. King and Newsholme and the con- veniently available statistics, chiefly those published by the city of Amsterdam in 1911-12, and the annual reports for the registration area of the United States. A death rate from any special cause could not possibly continue to increase indefinitely and at a 'progressive rate. It is self-evident that a death rate from any cause when once it reaches con- siderable proportions must naturally diminish in its rate of increase, because of inherent limitations. This applies to population growth as well as to mortality. The argument is the same as is frequently advanced in the case of tuberculosis, where it is claimed by the superficially informed and by those untrained in statistical analysis that, because the decline in the tuberculosis death rate in recent years has been at a lower rate than in former years, the deliberate effort to bring about a reduction in mor- tality has been largely a failure. f Combining the principal European countries for the period 1896-1900, the average cancer death rate during that period was 69.1 per 100,000 of population. It was as high as 127.4 in Switzerland and as low as *The most thorough consideration of this aspect of the problem is contained in the 76th Annual Report of the Registrar-General of Births, Deaths and Marriages in England and Wales, London, 1915. tFor a discussion of the statistical aspects of the tuberculosis problem, with special reference to the decline in the death rate, see my address before the National Association for the Study and Prevention of Tubercu- losis, Washington, May 8, 1913. 46 THE INCREASE IN CANCER 30.7 in Hungary. During the five-year period ending with 1905, the rate increased to 74.2. The actual increase in the rate was therefore 5.05 per 100,000 of population. The rate for Switzerland during this period was as high as 128.3, and for Hungary as low as 39.1. During the five years ending with 1910 the average cancer death rate for European countries was 81.0. There was therefore an actual increase in the rate of 6.81 per 100,000 of population, against 5.05 for the previous quinquennial period, and the percentage of increase in the rate was 9.2, against 7.3 for the previous five years. The theory advanced by Prof. Willcox is therefore not sustained by the facts of actual experience, which, to the contrary, prove beyond a doubt that the actual as well as the relative increase in the cancer death rate in at least some of the more important countries continues progressively at the present time and that for most of the civilized countries a maximum rate is far from having been reached. The Menace of Public Ignorance and Indiflference The cancer problem is one of the most difficult and perplexing in medi- cine, surgery and statistics. The mortality from cancer is no longer to be considered indifferently, for it constitutes a real menace to all civilized mankind. Irrespective of the reasons w hy the aggregate mortality from this disease should be so large, amounting, now (1915), in the Continental United States to over 80,000 per annum, it is a self-evident duty on the part of all familiar with the facts to discuss the subject, with a due re- straint in their utterance, but with clearness and fearlessness, so that the public may be made aware of the dreadful truth. It is entirely irrelevant and a wrongful use of the critical method to charge those who are con- vinced that cancer is becoming an increasing menace to civilized peoples with an exaggeration of the situation or with an undue excitement of the public. No harm is ever likely to come to any person by being unduly alarmed on this account.* The harm and the dreadful seriousness lie in ignorance and indifference and in confusion worse confounded by need- less controversies over matters which in themselves are at most and at best but secondary to the supreme question as to how malignant dis- ease can be controlled ; how it can be prevented, on the one hand, and how it can be successfully cured, on the other. f *The psychological aspects of the cancer agitation have been discussed by Dr. Romer, of Stuttgart, in the Journal of the German Society for Cancer Research, Berlin, 1906, Vol. iv. fFor a general statement of these aspects of the cancer problem, gee my address on "The Menace of Can- cer," transactions of the American Gyijecologjcal Soyety, 1913, 47 CHAPTER IV MORTALITY FROM CANCER IN DIFFERENT OCCUPATIONS Review of the Literature on Cancer in Relation to Occupation — Cancer in the Patent-fuel Industry — Pitch Ulceration and Paraffin Cancer — Occupational Incidence — Alco- holism — Prisons and Asylums — Petroleum Industry — Malignant Disease of the Lungs in Miners — Gardening and Agriculture — Cancer among Paraffin-workers — Brewers — Furriers and Skinners — Seamen — Tinplate-workers — Lead-workers — Rubber- workers — Chemical-workers — X-ray Workers — Cancer and Exposure to Light — Cancer in the Synthetic-dye Industry — Occupational Mortality Statistics — Life Insurance Experience — Foreign Statistical Investigations — Requirements of Scientific Statistical Research. A full discussion of the occupational aspects of the cancer problem is at present out of the question, on account of the paucity of data and the doubtful value of a considerable amount of available statistical informa- tion. Most of the cancer statistics by occupation fail to differentiate the organs and parts of the body affected, so that the initial seat of the disease can not be correlated to the known factors or conditions producing irrita- bility, or traumatism, and the resulting malignant growth. Authori- ties on the subject of workmen's compensation for industrial diseases are very guarded in their references to the interrelation of accidental injuries to cancerous growth, excepting such forms of malignant disease as will subsequently be discussed, with the required brevity, but in sufficient detail to emphasize the points of most practical importance. From a statistical point of view, however, the occupational aspects of the cancer problem are of exceptional interest and deserving of much more technical consideration than has been given to this phase of the subject in the past. The evidence is apparently conclusive that specific injuries to different parts of the body, whether internal or external, especially injuries resulting in a long-continued condition of slight irritability, may develop into cancerous growths of every known variety and degree of malignancy.* The frequency of cancer naturally varies widely in different occu- pations and industries. The results of statistical investigations regard- ing cancer frequency in different employments are, however, often con- tradictory and, on the whole, rather inconclusive. Cancer as a cause of invalidity is, according to German experience, not of serious importance. Out of every 1,000 recipients of invalidity annuities, the proportion retired on account of cancer was 16 for males and 21 for females. The corresponding proportions for tuberculosis of the lungs were 122 for *The earliest reference to tumors in relation to occupation occurs in "A Treatise on the Diseases of Trades- men," by Ramazzini, of which an English translation was published in London, 1705. The references are practi- cally limited to ulcers, the term tumor being used only once in connection with the diseases of musicians and others of this profession. Ramazzini was an exceptionally careful observer, and it is a reasonably safe inference that if malignantdiseasehadbeenascommonasitis to-day, he would have given a descriptive account of it in his work. Thackrah iu his treatise on the effect of arts, trades and professions on health and longevity, published London, 18:i'2, makes,amongothers,thefollowingreferences to cancer in relation to occupation. He mentions a French authority to the effect that shoemakers are subject to cancer of the stomach; that bakers are subject to tumors; that grocers are liable to a cutaneous eruption, or a variety of eczema, produced by handling sugar, and that victims of mental depression and care aje peculiarly liable to scirrhus of the stomach, medullary and fungoid tumors and other malignant disease. 48 CANCER AND OCCUPATION males and 76 for females. The relative importance of cancer as a cause of invalidity is brought out by the fact that in German experience it was the seventeenth most important cause among males, and the fifteenth among females. Sir Thomas Ohver, in his treatise on "Dis- eases of Occupation," has observed that The relation of malignant disease and injury is frequently raised in medico-legal in- quiries. That cancerous and sarcomatous tumors develop after an accident, close to the site of the injury, and that the one is the direct sequence of the other, there is not the least doubt. How the tumor comes we do not always know. A man receives an injury to the right side of his chest and dies ten months afterwards from malignant disease of the liver; another man falls on his head in a shipyard, and a year or two afterwards dies from a sarcomatous growth in the brain. In some cases the connection is clear enough and the claim for compensation can be honestly maintained, but it is absolutely necessary, in all such cases leading to a fatal termination, that a post-mortem examination should be made in order to ascertain whether what is apparent on the surface of the body is the primary or secondary growth. Chimney-sweeps' Cancer Concerning chimney-sweeps' cancer the same authority remarks that Men following this employment exhibit a liability to cancer several times greater than that of the general population. There is the opinion that the irritant in soot is arsenic, but whether it is this or sulphurous acid or ammonia compounds it is difficult to say. In New- castle-upon-Tyne we seldom see cases of chimney-sweeps' cancer, although it was the cause of death of one sweep in 1907. In the I-ondon hospitals and on the Continent it is not met with so frequently as formerly. According to statistics suppUed by Dr. John Tatham, of the General Register Office, the comparative mortaUty figure for cancer among chimney-sweeps between the ages of 25 and 65 for the three years ending 1902 was 133 as compared with 63 among occupied males at the same ages. This is a lower death rate from cancer in chimney-sweeps than three decades ago, and even later. In his article on dust-producing occupations in "Dangerous Trades," Dr. Tatham gives as the mortahty figures from cancer 156 for chimney-sweeps compared with 44 for occupied males. While, therefore, the mortality from cancer has been diminishing in chimney-sweeps, it has been rising in the general population. Although usually met with in the region of the scrotum, the disease may appear on any part of a chimney-sweep's body. It is usually preceded by one or two small warty growths which ulcerate, and these, failing to heal, assume the character of an epithehoma. The glands in the groin subsequently become enlarged, first from irritation and secondly from mahgnant infection. The disease makes slow but steady progress. Ultimately secondary deposits occur in such of the internal organs as the liver and lungs and in the peritoneal cavity. Gardeners' Cancer With reference to gardeners' cancer Sir Thomas Oliver points out: Gardeners who are in the habit of sprinkhng soot upon plants to protect them from slugs occasionally develop cancerous ulceration of the hand. Soot when repeatedly applied to the skin causes it to become thickened, harsh, and dry. Once structural altera- tions are induced in the skin, repeated irritation may lead to cancer. Coal-tar and Pitch Industries The same authority refers briefly to workers in coal-tar and pitch, etc., as follows : Men who work in tar and paraffin and in anthracene, a product obtained from the distillation of gas-coal tar, are specially prone to suffer from warts and skin eruptions. Distillers of benzine and creosote suffer in a similar manner, although not so frequently. Ulcers of the skin in persons who are working among coal-tar and pitch products ought not to be neglected. In the first instance the ulcer may be of a simple character and will heal if properly treated and kept free from irritation. Should it cease to heal, extirpation by the surgeon may be required. THE MORTALITY FROM CANCER The liability of tar and pitch workers to cancerous affections is more fully discussed by Sir. Thomas OUver in the extract given below; Many of the men who follow the employment not only become bronzed and sallow, but their skin becomes the seat of a pecuhar cancroid eruption such as is occasionally met with on the scrotum of chimney-sweeps. In other persons there may be bronchitis, digestive disorders with dark stools, also ulceration of the nose. The question as to whether manipulation of tar products or exposure to the fumes given off by coal-oil and tar is capable of giving rise to cancer has come before me in the case of three men employed in grease works. These men in follo-ning their employment all worked with their sleeves rolled up to above the elbow. It has been observed in the trade that when men have M'arts on their hands these frequently disappear when they first undertake the work, and, on the other hand, that in men whose skin has been quite healthy, wart-like growths are apt to develop when they have followed their employment for some time. In addition to the warts, of which there may be as many as from thirty to forty on the hands and forearms, there develop hard nodules in the skin which ulcerate and often exhibit very little tendency to heal. The edges become hard, and the ulceration, extending to the deeper tissues, may ultimately involve t' e bone and necessitate, as in the case of one of the men I have alluded to, amputation of the arm. The appearances presented by the ulcer are those of the type of cancer known as epithelioma. The presence of these warty growths on the forearms and hands, and of ulcers that tend to take on malignant characters, in tar and pitch workers is so frequent that they must be in some way or other associated with the employ- ment. The morbid processes advance very slowly, and therefore do not readily unfit the individual for work. In many instances removal of the ulcer is not followed by any recurrence of the growth, but a return to the work lays the person open to fresh develop- ments. On the forearms of one of the grease workers above mentioned there are numerous small patches of induration, some of which have ulcerated and exhibit no tendency to heal. The edges of the ulcers are hard and brawny. There are, in addition, scattered all over the forearm numerous black warts of various sizes, also several scars of a pale color compared with the bronzed skin that surrounds them. One of these men, aged fifty-eight, has worked among coal-oil and tar products for thirty years. The scars referred to are the remains of ulcers that have healed. In the case of his son, aged twenty-seven years, the ulceration took on the characters of malignant disease, and on that account the arm had to be amputated above the elbow. Although it is usual when the disease is treated by surgical operation for no recurrence of the growth to take place, in this particular instance the glands in the armpit and neck became subsequently enlarged owing to infective parti- cles having reached these glands by the lymphatics, and the patient became the subject of secondary cancer. Microscopical examination of the ulcer leaves no doubt as to the cancerous nature of the lesion. Cancer as an Occupational Disease The predisposition to cancerous affections in certain occupations is attracting attention on account of the pecuniary aspects of the modern doctrine of workmen's compensation. In a treatise on "The Law of Compensation for Industrial Diseases," by Edward Thornton Hill Lawes (London, 1909), the subject is referred to in part, as follows: Epitheliomatous Cancer or Ulceration of the Skin, or of the Corneal Surface of the Eye, due to Pitch, Tar, or Tarry Compounds. Description of Process. — HandHng or use of pitch, tar, or tarry compounds. EpitheUoma is a cancerous growth of the cells of the skin. It is the least malignant form of cancer, and on removal it is not usually followed by recurrence. Tar has a pecuhar and irritating action upon the skin which varies in intensity. Those who handle and use pitch or tarry products, men employed in unloading, in making bri- quettes (which are a mixtiu-e of pitch and coal dust), in handling "coal oil" or creosote, are all liable to suffer from warty growths, which ulcerate and may become the seat of epithe- liomatous cancer. The growths occur on any part of the body, especially the faice, hands, and scrotum, and are often accompanied with a dark pigmentation of the skin. They commence as small nodules, but soon break down, forming an ulcer covered by a crust, which gives the appearance of the so-called wart. The underlying ulcer almost invariably heals up, leaving a small scar when the crust has fallen off. If the growth becomes epitheli- omatous the situation is almost invariably on the scrotum, when it involves the neighboring 50 CANCER AND OCCUPATION organs and tissues. It ia then much the same as chimney-sweeps' cancer, and may be serious, as it can only be arrested by free excision, and the patient may lose one or both testicles. Cleanliness is a very necessary precaution, but in spite of this, the disease may develop. The length of the incapacity is not great in most cases, and the worker may completely recover and resume his work. Particles of pitch striking the eye may cause inflammation of the conjunctiva (the mucous membrane covering the eye-ball) and the cornea. This may be very serious; cases of this kind are said to do very badly. It is said that the pitch getting into the surface of the eye causes a wound which lets in bacteria which induce a septic inflammation, and there is danger of loss of sight. Scrotal Epithelioma (Chimney-sweeps' Cancer). Description of Process. — Chimney sweeping. Soot sets up an irritation of the skin similar to pitch and tar, and with similar results as described under the last heading. This cancer of the scrotal region is so prevalent amongst chimney-sweeps that it owes its name to this fact, and though it is occasionally found in other people, it is distinguished from other forms of cancer, and is characteristic of the trade, and is therefore scheduled separately. Amongst chimney-sweeps it has been the cause of excessive mortality. According to the Registrar's figures for three years the comparative mortality from this disease was 133 per 1,000, as against 63 amongst other* occupied males of the same ages [i. e., 25-64]. This form of cancer is invariably cutaneous and of slow growth : it is frequently pre- ceded by a warty ulcerous growth, which may exist for some time before becoming cancer- ous, but the warts described as common among pitch workers are not so frequent in chimney-sweeps. There is probably some unknown property in soot which makes it cancerous: not merely its grittiness. See, however. Dr. Butlin's opinion contra, p. 56 of the Minutes of the Industrial Diseases Committee, 1907. Cleanliness is an important precaution. Cancer in the Patent-fuel Industry The following are interesting references to cancerous affections in certain occupations, from the annual report of the Chief Inspector of Factories and Workshops for 1908: The reportable cases of epitheHoma are likely to increase in nimaber as this addition to the schedule of diseases of occupation becomes better known throughout the large patent fuel works in certain parts of the divnsion. Mr. Hilditch (Swansea) reiterates his opinion that anthracene is the root cause of this trouble. In support of that view he cites the case of a man, recently seen by him, who was covered with warts on the exposed sur- face of his body, and who had been using anthracene oUs for many years, but had not been employed at patent fuel or tar distilling works, neither had he handled much pitch. No doubt in consequence of the prominence given to epithehomatous cancer and pitch ulceration by inclusion in the third schedule of the Workmen's Compensation Act, 1906, four reports were received of cases in the fuel works of Swansea and Cardiff in which operation had been necessary. Mr. Owen Edwards (Cardiff) investigated the cases in Cardiff and, helped by Dr. Paterson of that town, brought to light four other cases. With Mr. Edwards I \'isited the fuel works in his district and examined over 100 men. No new cases wepe discovered, but the skin of several workers showed the characteristic warts. Further inquiry by us is in progress for the purpose of securing generally throughout this industry provision of sufficient and suitable washing and bath acconamodation, as there is general consensus of opinion that the cancerous condition can be prevented by scrupulous cleanliness. Dr. Collisj on information received from a certif jang surgeon, examined the workers in an engineering workshop, some of whom were suffering from eczematous ulceration of the hands and arms, attributed to a doubly refined Russian turpentine. Two sets of men suffered (1) those employed in wiping steel plates with turpentine, and (2) those using a paint made up with the same turpentine. Of twenty men thus employed one-half were or had been affected. He recommended (1) a different turpentine in the mixing of the paint, (2) supply of grease for removing the paint from the sldn instead of the tm-pentine which was being used, and (3) leather or other hand holders reaching half up the forearm for men engaged at the power presses. In the report of the Chief Inspector of Factories and Workshops for •This should read "all occupied males." 51 THE MORTALITY FROM CANCER 1909 occurs the following description of ulceration of the skin and epitheliomatous cancer in the manufacture of patent fuel and grease: The inquiry into this subject made by myself, in Cardiff with Mr. T. Owen Edwards, and in Swansea with Mr. J. H. Hilditch, has been pubHshed as a separate report. The number of men examined was 277. In those most exposed to pitch dust the hair follicles and sebaceous glands become the seat of a minute plug of pitch. Irritation with formation of shotty papules follows as the secretion of the glands becomes obstructed. These are most marked on the forehead, neck, and ulnar side of the forearms. The sebaceous glands, especially behind the ear where washing is less likely to be thorough, become very promi- nent and comedones are generally noticeable. Sometimes there are scattered patches of pigmentation over the arms with hyperaemia and distension of the small veins, or the epithelial layers of the skin become thickened with formation of definite warts. Only exceptionally do the warts take on a malignant character, and then usually, but by no means invariably, the scrotum is the seat of the lesion. Suggestions for regulations to apply to occupiers and persons employed were made in the report, including (1) bath (preferably douche bath) and washing accommodation, (2) overalls, (3) encasing of elevators and disintegrating machines, and (4) wire goggles to prevent damage to the eyes from flying particles of pitch in breaking, crushing, etc. Protective Regulations Draft regulations providing for the sanitary conduct of the patent- fuel industries are referred to in the report of the Chief Inspector of Factories and Workshops for 1910: Manufacture of patent fuel and grease. — As the result of inquiry and report by Dr. Legge on I'.lceration of the skin and epitheliomatous cancer to which the workers in these trades are liable, draft regulations have been drawn up for the manufacture of patent fuel and issued to the manufacturers concerned. Certain objections to these have been re- ceived, and the Secretary of State has, in pursuance of s. 81, appointed Mr. A. H. Lush, barrister-at-law, to hold a public inquiry. As regards the actual frequency of epithelioma in the patent -fuel in- dustries, the following extract from the annual report of the Chief Inspector of Factories and Workshops for 1911 is of interest: Epithelioma. — Eleven cases under this head were reported from patent fuel works in the Cardiff and Swansea districts, but none of them appear to have been serious. Also the following in connection therewith, from the same report, on the proposed draft regulations for the industries engaged in the manufacture of patent fuel and grease: Following on the receipt of objections to the draft regulations issued in 1910 for this industry, the Secretary of State, in pursuance of s. 81, appointed Mr. A. H. Lush, barrister- at-law, to hold a public inquiry, which was opened at Cardiff on April 26, 1911, and con- tinued there and at Swansea and London on thirteen subsequent days. The Commis- sioner* recommended that further consideration of the draft regulations should be de- ferred until October, 1912, to allow time for experiments which the employers, with the cooperation of the workmen, were prepared to undertake. These will necessitate the installation of baths on a moderate scale in one or more of the principal factories at Cardiff and Swansea; volunteers from among the men will give the baths a fair and complete trial, by taking a bath daily for at least a week. By this means, it is hoped to settle the question whether the cleansing of the skin is not more effective, and the tendency to irritation less, if the washing is done immediately after work, when the skin is still hot and the pores open. Investigation is also being made as to other matters, especially as to the possibility of adopting some form of overalls and goggles suitable to the special conditions of this trade. Eczetnatous Ulcerations Some extended comments on eczematous ulceration in the manufac- ture of pitch, brought out by means of a prolonged inquiry held in South 'Report to the Secretary of State on the draft regulations proposed to be made for the manufacture of patent fuel (briquettes) with addition of pitch (London: Wymaa & Sons, Ltd., 1911. Cd- 6878). 52 CANCER AND OCCUPATION Wales, are given in the report, but they can not be included in the present abbreviated account. They, however, should be taken into con- sideration in connection with any special study of the subject. The following portion of the remarks is pertinent to the present discus- sion: Incidentally the inquiry in an unexpected manner gave an impetus to the subject of can- cer research. When the draft regulations were first issued objection came from two iron works in Scotland, where briquettes were made as a very subsidiary business, that evidence of warts, so common among workers with gas works tar pitch, was absent in persons handling blast furnace pitch. This I found was the case and a clause had to be added to the draft regulations expressly exempting from their scope factories or workshops in which no pitch other than blast furnace pitch was used in the manufacture of briquettes. There are marked chemical dififerences between the two kinds of pitch, depending partly on the nature of the coal from which they are derived and partly on the much lower temperature of distillation of blast furnace than coal gas tar. Sanitary Precautions A special report upon the progress made in the South Wales patent- fuel works, following the recommendations of the commissioner appointed to investigate the industry with reference to pitch ulceration, is referred to in the annual report of the Chief Inspector of Factories and Workshops for 1912. It is stated that Washing accommodation has been provided, and suitable use made of it in some of the works. Elevators for the mixture of pitch and coal have been encased, and attempts have been made to relieve the skin irritation by the use of lotions and ointments. The public inquiry will be resumed during 1913. A more extended reference to the subject of pitch ulceration occurs in the same report, being the observations of the Medical Inspector, as follows : Dr. H. C. Ross has widened considerably his experiments in connection with this sub- ject.* From Mr. W. J. A. Butterfield, F. C. S., Secretary of the Metropohtan Gas Referees, he received a number of samples of different kinds of pitch, coal tar fractions, distilling at different temperatures, and from them he concluded that the dangerous principles are contained in the heavy oils of the coal tar. They can not be distilled out completely with- out ruining the pitch, but it would be well if distillation were carried to the utmost point compatible with producing serviceable pitch. The dangerous principles are not anthra- cene or anthracene oil, but are probably some substances intimately mixed with them which distil over at the same temperatures. What they are we do not yet know. Dr. Ross, after experiment, does not consider acridine to be the cause of the trouble. For the purpose, however, of ridding the tar of the noxious ingredients, washing the tar, if the works concerned can undertake it, offered, so far as he could see, much the most satis- factory solution of the difficulty. Tar distillers, unfortunately, represent that water is their greatest enemy, and if so treated processes of distillation would become dangerous from the frothing of the tar in the stills, as the only means of separation would be by distillation. In later investigations with numerous samples of coal. Dr. Ross has found both auxetic and kinetic properties present in bituminous samples, but in no case to anything Uke the degree they are in pitch or tar. Progress has been made in the South Wales patent fuel works, following on the Com- missioner's recommendations (to which reference was made in the last annual report). Washing accommodation has been provided, and suitable use made of it in some of the works. Elevators for the mixture of pitch and coal have been encased, and attempts made to relieve the irritation caused to the skin, by use of lotions and ointments. The pubUc inquiry will be resumed in 1913. Cases of similar epithehomatous ulceration have been reported during the year from tar works. The established occurrence of cancer as an incidental result of the manufacture of patent-fuel, or fuel briquettes, consisting of coal-dust and *"The Problem of Gasworks Pitch Industries and Cancer," John Murray, London, 1912. 53 THE MORTALITY FROM CANCER pitch in the usual proportion of nine to one, suggests the importance of a careful study of this industry in the United States, since the same has as- sumed considerable proportions within recent years. There were nine- teen plants engaged in the manufacturing of fuel-briquetting in 1912 using as a base anthracite culm, bituminous or semi-bituminous slack, carbon residue from gas manufacture and peat. The binders used varied also, and of the nineteen plants in commercial operation during 1912, ten used coal-tar pitch as a binder, one used asphaltic pitch, two used water-gas pitch and four used mixed binders, the composition of which was not made public. There appear to be few recorded cases of so-called pitch cancer in this country, but it is quite possible that in- creasing attention and more careful observation may prove that ulcera- tions of the skin, and possibly cases of true cancer, occur in this country, as well as in England and Wales, in connection with the manufacture of patent-fuel, etc. It should be stated, however, in this connection, that a case of multiple cancer of the skin in a tar-worker, who developed .several scores of epithelial lesions in various stages of development upon the hands and forearms and a large epithelioma upon the scrotum, has been re- ported by Dr. J. Frank Schamberg, of Philadelphia. The case suggested to Dr. Schamberg the possibility of radio-activity in coal-tar, and to test this assumption, according to the Medical Record, he "placed a copper cent, a flat key and a small brass numeral upon a photographic plate in a pasteboard negative box lined with black paper. Upon the under surface of the lid he attached a piece of cardboard smeared with coal-tar, so that the board faced downward. This box was placed in a black Japan tin cash-box and the latter was shut in a dark closet for twenty- four hours. When the plate was developed a distinct shadowgraph of the three objects was seen on the negative." This test of coal-tar radio- activity is conceded by Dr. Schamberg to be hardly conclusive, but he observes that "If coal-tar was proven to be radio-active, it would seem that this radio-activity might be responsible for the cancer in tar- workers." According to another account. Dr. Schamberg examined about twenty men whose work caused them to be smeared with tar. In the manufacture of tar-paper the men's arms are soiled with tar and their clothing is more or less saturated. Most of the men said that they suffered from time to time with outbreaks of "yellow-heads" on their arms, but these soon passed away. In a number of workmen he saw mild acne-form eruptions on the arms resembling a folliculitis. Five workmen were found showing evidence of beginning or well-developed cancer.* Recent Data on Pitch Ulceration and Paraffin Cancer The subject of 'pitch ulceration is again referred to in the annual report of the Chief Inspector of Factories and Workshops for the year 1913, with special reference to the second report of the Special Commissioner on the draft regulations for the manufacture of patent-fuel with addition of pitch. In the light of practical experience it was found that the regulations were burdensome and not effective; and no evidence had been forthcoming to prove that the taking of baths was a complete *An extended discussion on the relation of tar and paraffin manufacture to cancer occurs in the second volume of J. Wolff's treatise on Cancer, pp. 145-149, 54 CANCER AND OCCUPATION prevention of the evil, nor was it evident that this requirement would be suitable for all workmen under all conditions. It had thus become obvious that the objects of the draft regulations might be better secured by some other method and it was therefore intimated that the regula- tions might be withdrawn "provided a satisfactory arrangement could be come to for carrying out voluntarily by the employers certain im- provements which the home office deemed essential for the protection of the workers." A new arrangement satisfactory to all parties con- cerned was therefore made, including provision for baths, wash-basins and accommodation for clothing, on a scale which, in the absence of compulsion, should be amply sufficient for all requirements, and also the encasing of the coal-elevators, as well as those that carry the mixture of coal and pitch, to the reasonable satisfaction of the Inspector of Factories. The number of cases of pitch warts, or of epitheliomatous cancer as a result of them, which were reported to the Factory Inspection Department during the year 1913 was 19, of which 3 were recurrences in persons previously reported. A reference occurs in the Annual Report for 1913 to a number of cases of "Paraffin Cancer," defined as a disease shale-oil workers are peculiarly lialj)le to suffer from. The disease is briefly described as "having its onset in a variety of forms, i. e., as an erythema, pimples, papules, etc., these gradually dry up, forming hard crusts, which, increasing in size, form hard elevated wart -like masses. As they increase in size these break down, forming sloughing ulcers or paraflBn cancers. He mentions three cases: (1) On the dorsum of foot, doing well after operation; (2) scrotal, so far doing well after extensive operation, and (3) back of wrist, necessitating amputation of the right arm at shoulder." The process is quite fully described and the conditions are pointed out under which the disease may be made subject to a reasonable degree of control. The border-line between cases of this kind and benign skin affections due to occupational exposure is ill-defined. An increasing amount of trustworthy evidence is, however, gradually becoming available, which would seem to warrant the conclusion that malignant disease as the result of occupational exposure is of more serious importance to the workers affected than is generally assumed to be the case. * Mortality from Cancer in Different Occupations A general discussion of cancer in relation to occupation occurs in the treatise on "The Natural History of Cancer," by W. Roger Williams. On account of the high authority of Dr. Williams, his observations are given in full, as follows: Although it cannot be said that persons of any rank or station in life are exempt from cancer, there are, nevertheless, some remarkable differences in the incidence of the disease, among the various social strata. I have already had occasion to point out the much greater prevalence of cancer among the well-to-do, and among the agricultural community, than among the less prosperous of the industrial classes in our great towns, as well as its comparative rarity among paupers, lunatics, and the prison population. Perhaps the most significant result hitherto attained by statistical investigation of this subject, is that arrived at by Dr. Tatham, who found that the mortality from cancer during the decennium 1881-1890, was more than twice as great among well-to-do men *See in this connection a recent treatise on "Occupational Affections of the Skin," by R. Prosser White, Lon- don, 1915, pp. 26, 85, 93-94; also "Diseases of the Skin," by Ernest Gaucher, London, 1910, pp. 186,267,440. 55 THE MORTALITY FROM CANCER having no specific occupation, as among occupied males in general, the respective cancer mortality ratios being 96 for the former and only 44 for the latter. In like manner, Aschoff has shown that, in the Berlin population, cancer was of most frequent occurrence among persons of independent means, living on their income or pension. All statistics show that printers, compositors and pressmen experience a very low cancer mortality, while their death rate from tubercle and their general mortality are both very much in excess of the average; and this class is notoriously one of the most intemperate as regards alcohol, etc., in all modern communities. According to the Twelfth United States Census Report, for the year 1900, the cancer death rate for this class was £2 per 100,000 Uving, the corresponding figure for pulmonary tubercle being 435. Another class of workers but little prone to cancer are the miners — especially coal miners — and quarrymen; the United States statistics for this class show a cancer death rate of 33; and a phthisis death rate of 120. Aschoff 's Berlin data place the miners next to the printers, in respect to comparative immunity from cancer. In England, there are few districts where cancer is less prevalent than in the great colliery centres of Derbyshire, South Wales, Durham and Lancashire; and in the mining and quarrying districts of Cornwall, North Wales and elsewhere, very low cancer death rates also prevail. With regard to the very high mortality of chimney-sweeps from cancer, as shown by the English national statistics, I am inclined to think that the calculation is based on too small a number of cases to give a reliable average, and is otherwise defective; at any rate, nothing of the kind has been noted in the United States, nor in Continental European countries.* Moreover, cancer of the corresponding anatomical part in women — the vulva — is nearly as common as cancer of the scrotum in males; for, of 4,628 primary cancers in females, 104 were of the vulva, or 2.2 per cent.; while of 2,669 cancers in males, 76 were of the scrotum, or 2.8 per cent. In general, cancer is comparatively infrequent among the working classes of our large towns, especially in the great industrial centres, and among the cotton and textile opera- tives, iron and steel workers, etc. On the other hand, among the well-to-do, the cancer mortality is certainly much in excess of the average. Thus, among the leisured and pro- fessional classes, the United States Census Report — for 1900 — shows that high cancer death rates prevail, especially for the clergy, merchants, brewers, hotel and restaurant keepers, hotel servants, butchers, agriculturists, sailors, commercial travellers, car- penters, etc. Workers in soot, tar, paraffin, arsenic, etc., are specially prone to certain forms of cutaneous cancer; and it has been reported, that those employed in particular cobalt and nickel mines are prone to quasi-malignant pulmonary disease. There are good reasons for believing that farm laborers, gardeners, sailors, and those who follow out-of-door occupations are imduly prone to cancer of the lower lip. Of 36 men with cancer of the lower lip who came under my observation in London hospital work, 5 were farm laborers, 5 general laborers, 3 sailors, 2 bricklayers, and 1 each as follows: sadler, cowman, blacksmith, stoker, worker in a paper factory, piano-maker, sewerman, bailiff, gardener, brazier, carpenter, gas-fitter, costermonger, carman, commer- cial agent, boatman, waiter, soldier, fireman and groom. The large proportion of patients engaged in out-of-door occupations comprised in this list is very remarkable; especially when regard is had to the sedentary occupations followed by the great bulk of the London population, whence these cases were drawn. With regard to the influence of occupation on the liability of women to malignant disease, perhaps the most significant item hitherto elicited is that brought out by the United States Census Report for 1900, which shows that domestic servants are unduly prone to cancer; thus, during the age-period forty-five to sixty-five, their mortality from this cause was double the average; and, at ages above sixty-five, it was triple the average. Cancer death rates, above the average, were also noted among nurses, midwives and school- teachers.f With regard to the female hospital patients with cancer, under my observation, most of them had been supported entirely by their husbands' earnings; but such of them as had worked for their living — whether married, widowed or single — had followed the following occupations in 142 cases: thus, domestic service, 62 (cook, 17, charwoman, 13, house- *Chimney-sweeping as practised in England is virtually an unknown occupation in the United States. fAll of these observations and conclusions, especially with reference to conditions in the United States, must be accepted with extreme caution, on account of the paucity of the data considered and the probable incompleteness of the census returns. 5Q CANCER AND OCCUPATION keeper, 6, other forms of domestic service, 20); needlework, dressmaking, etc., 28; sick nurse or midwife, 16; laundry, IG; governess or school-teacher, 7; factory, 7; shop assistant, 4; barmaid and actress, of each 1. Relative Occupational Incidence Among the more recent authors on cancer, a brief reference may be made to the observations by Charles P. Childe, in his treatise on "The Control of a Scourge; or How Cancer is Curable," published in 1906: No theories that I am aware of have been formulated in regard to occupation as a cause of cancer. The following comparative mortality returns, emanating from the Registrar- General, show that no occupation is exempt from it, just as no climate or locality is exempt from it, but do not suggest any conclusion as to its origin being dependent upon occupation or habits of life. All occupied males, 44; all unoccupied males, 96; grocers, 34; clergy, 35; potters, 35; coal-miners, 36; farmers, 36; fishmongers, 42; medical practitioners, 43; black- smiths, 45; fishermen, 46; porters, 48; general laborers, 48; drapers, 49; shoemakers, 50; dock and wharf laborers, 51; tobacconists, 51; plumbers, 53; inn- keepers, 53; coal-heavers, 56; butchers, 57; coachmen and grooms, 58; tool and scissors makers, 58; gas-workers, 59; lawyers, 60; merchant seamen, 60; maltsters, 61; commercial travellers, 63; inn and hotel servants, 65; brewers, 70; inn-keepers in London, 70; chimney-sweeps, 156. An exanaina- tion of these figures apparently proves cancer to be very haphazard in the selection of its victims, except in the case of chimney-sweeps, who, it will be seen, more than double any other class. This exception has generally been considered evidence that it is connected in its origin somehow wnth local irritation of various kinds, soot being the f oris et origo viali in this instance.* Apart from this exception, the figures apparently leave us in the dark. For instance, we find clergy sandwiched in between grocers and potters, medical practi- tioners between fishmongers and blacksmiths, lawyers between gas-workers and merchant seamen, and so on. The tables seem to show that it is more a matter of chance than any- thing else, and that occupation has nothing to do with it. Relation to Alcoholism The subject of cancer in its relation to trades and occupations is discussed by Hollo Russell, in his treatise on "Preventable Cancer,"t in part, as follows : A few observations, which have been confirmed by all later experience, were made forty or fifty years ago on the excess of cancer to which certain occupations were liable. It has long been known that chimney-sweeps in England have been attacked in a particular way, and it has been known for some years that gardeners and others who handle soot, tar, etc., are more likely than others to be attacked by cancer in the hand. After discussing the comparative mortality from cancer and alcohol- ism in specified occupations, J Russell points out that The record exhibits very clearly the liability to excessive liquor-drinking in all these occupations, especially in brewers, sweeps, general laborers, and butchers, and may be compared with the high cancer rate of the same trades. The excess in sweeps tends to prove that the condition of body and blood renders them specially liable to the local dangerous irritation of sooty naatter. This explains the non-liabihty of foreign sweeps, *Since the use of the long brush for sweeping chimneys, chimney-sweeps' cancer is diminishing. t'Treventable Cancer," RoUo Russell, London, 1912. fThe relation of alcoholism to cancer has been discussed in "A Second Study of Extreme Alcoholism in Adults," published by the Sir Francis Galton Laboratory for National Eugenics, London, IQl^. The occasion for the discussion was an extended reference to the alleged excess in the mortality of inebriates from malignant disease and tuberculosis, summed up in the statement that cancer was more than eight times more common among inebriates than among the population of the country at large. Subjecting the data to critical analjsis, it was found by Mr De vid Heron, in charge of the investigation, that, quite to the contrary, the actual mortality from cancer among the inebriates exposed to risk was less than the expected. Both investigations, however, are im- paired in value by the paucity of the data considered, there having been only 865 inebriates exposed to risk, of which ten suffered from cancer and [five died from the disease during sentence. Out of 2,767 inebriates committed to the reformatory, twenty-four suffered from cancer, of whom ten died from the disease. It would obviously be unsafe to rest far-reaching conclusions one way or the other upon so small a numerical basis of fact. 57 TEE MORTALITY FROM CANCER who are not particularly intemperate, to sweeps' cancer.* In the United States, sweeps' cancer is almost unknown; in Belgium, where coal like the English is used, there is almost complete immunity, but great care is taken to 'prevent contact vntk soot; in Germany the practice is to wash daily from head to foot. An investigation of cancer statistics in Germany by the German Committee for Statis- tical Study was analyzed by Dr. Hirschberg. In men, cancer of the stomach preponderates, with 413 per mille; in women, cancer of the breast, with 243 per mille cases. No special trade liability was found in sweeps, chemical workers, etc. The agricultural classes were attacked more in the skin; those engaged in the timber trade more in the glands. Cancer of the urinary organs was specially common among the well-to-do. Acid wines and cider seem to give a predisposition to gastric cancer. In the report of the Commissioners of Prisons and the Director of Convict Prisons for the year ending March, 1911, it is stated: "Cancer, the mortality of which increases at every age-group and for each sex in the general population, is again noticeably low in the prison death rate, and this is not due to the fact that prisoners so suffering were released on medical grounds, for only three were released for this cause from local prisons." Cancer Occurrence in Prisons and Asylums After calling attention to the fact that on the basis of oflBcial reports the cancer mortality in asylums was exceptionally low, Russell remarks : The low rate of cancer in prisons and asylums is the more worthy of consideration on account of the class from which those detained are drawn. The prisons include a very large proportion of hard drinkers and unsound bodies. Yet the prison regime seems to prevent the evil seeds which have been sown from germinating abundantly. Similar ex- periences have been related of workhouses, and many old people who have chosen to quit them have very soon succumbed to common influences outside. Asylums contain an excessive number of persons who have inherited or acquired con- stitutional weaknesses, and in many cases tendencies towards consumption or cancer; also many alcoholics who are prone to these maladies. Yet the habits and rule of these in- stitutions reduce the cancer rate much below the rate of the classes from which they were drawn, and below the rate both of occupied and unoccupied persons. f Cancer in the Petroleum Industry ^ Numerous references to cancer and non-malignant skin eruptions among men in certain trades occur in the treatise on "Industrial Poisoning," by Dr. J. Rambousek, published in London in 1913. In connection with a discussion of the petroleum industry it is pointed out that The occiirrence of skin affections in the naphtha industry has been noted by several observers, especially among those employed on the unpurified mineral oils. Eruptions on the skin from pressing out the paraffin and papillomata (warty growths) in workers cleaning out the stills are referred to by many writers.f Ogston in particular. Recent literature refers to the occurrence of petroleum eczema in a firebrick and cement factory. The workers affected had to remove the bricks from moulds on to which petro- leum oil dropped. An eczematous condition was produced on the inner surface of the hands, necessitating abstention from work. The pustular eczema in those employed only a short time in pressing paraffin in the refineries of naphtha factories is referred to as a frequent occurrence. Practically all the workers in three refineries in the district of Czerno- witz were affected. The view that it is due to insufficient care in washing is supported by the report of the factory inspector in Rouen, that with greater attention in this matter on the part of the workers marked diminution in its occurrence followed. •The true cause of the difference is probably the non-use on the continent of the English method of chimney- sweeping. fThe large majority of persons in prison are, of course, below the age period of life when cancer is most fre- quent. According to a special investigation, made by me for the purpose, it was found that out of 309 deaths from all causes in American State Prisons during 1914 there were only 4 deaths from cancer, or 1.1 per cent. JM itchell, Jl/«dica/ Nev;s,Yo\.ui,p. 152; Annalise d'Hygiene public. Vol. xxiv,p. 500; Arlidge, "Diseases of Occupation"; Revue d'Hygiene, 1895, p. 160; Neisser, Intern. Uebers. f. Gew.-Hyg., 1907, p. 96. 58 CANCER AND OCCUPATION In connection with the coal-tar industry it is said : Workers coming into contact with tar suffer from an inflammatory affection of the skin, so-called tar eczema, which occasionally takes on a cancerous (epithelioma) nature similar to chimney-sweeps' cancer, having its seat predominantly on the scrotum. In lampblack workers who tread down the soot in receptacles the malady has been observed to affect the lower extremities and especially the toes. With reference to the anihne-dye industry it is stated that In 1903 a worker employed for eleven and a half years in the aniline department died of cancer of the bladder. Such cancerous tumors have for some years been not infre- quently observed in aniline workers, and operations for their removal performed. Ley- mann thinks it very probable that the affection is set up, or its origin favored, by anihne. This view must be accepted, and the disease regarded as of industrial origin. The frequency of tumors of the bladder among aniline-workers is briefly described in connection with the coal-tar industry as follows : The first observations on the subject were made by Rehn of Frankfurt, who operated in three cases. Bachfeld of Offenbach noticed, in sixty-three cases of aniline poisoning, bladder affections in sixteen. Seyberth described five cases of tumors of the bladder in workers with long duration of employment in anihne factories.* In the Hochst factory (and credit is due to the management for the step) every suspicious case is examined with the cystoscope. In 1904 this firm collected information from eighteen anihne factories which brought to light thirty-eight cases, of which eighteen ended fatally. Seventeen were operated on, and of these eleven were still alive, although in three there had been recurrence. Tumors were found mostly in persons employed with aniline, naphthylamine, and their homologues, but seven were in men employed with benzidine. Relation of Cancer to Injuries There is a brief discussion of occupational cancers in Greer's treatise on "Industrial Diseases and Accidents," published in London, 1909. The discussion is of exceptional interest in connection with the problem of workmen's compensation for industrial diseases and is therefore given in fuU: Workers in certain trades appear to be prone to suffer from cancer, as in chimney-sweeps, tar, pitch, grease and paraflBn workers; possibly bacon-curers (Oliver), aniline workers (Rehn). The relation of injury to the development of cancer has received a very great deal of attention, the result being that we are in a position to give to traumatism a place amongst the factors which influence the production of malignant growths. The real cause, though the object of numerous researches, has as yet baffled inquirers. At present we have a number of observations which go to prove that continued local irritation can determine the development of a malignant growth. We recognize under this head chimney- sweeps' cancer, tar cancer, clay-pipe cancer. X-ray cancer, etc. In this class of super- ficial cancers the relations of cause and effect are not widely apart. In the more deeply seated growths, especially those taking origin in muscle and bone, the sarcomata, we must admit that traumatism may play a causative part, though here the relationship is not quite so manifest. In this class the history is not usually that of continued irritation, but is the narrative of perhaps a single injury. If the deeply-situated organs, such as the lung, kidney, stomach, liver, intestines, etc., become affected with malignant disease, and there is an accoimt of an accident, it is very necessary before accepting the disease as of trau- matic origin that the records of the case should f lu-nish evidence that the organ in question was damaged at the time of the accident. If a long interval of time separates the develop- ment of the tumor from the accident, these records should show a certain continuity and sequence in the symptoms and signs following the injury leading up to that period in which the growth is revealed. On the whole question of the traumatic origin of tumors, Sand is of opinion that to establish the relationship it is necessary that the accident should have caused local lesions, swelling, pains, etc., that the growth should develop in the organ involved directly or indirectly in the accident, that the growth should appear within be- tween three weeks and a year for sarcoma (two to six months on an average), between six *Munchener mediziniache Wochenachrift, 1907, 59 TEE MORTALITY FROM CANCER weeks and five years (average one to two years) for cancer, between one month and ten years for glioma (malignant disease of nerve structures, brain, spinal cord and eyej, be- tween three weeks and two years for other tumors. The patient should not be the subject of tumors of the same class previous to the accident. The traumatic origin is more likely if the patient has been healthy up to the accident. Youth is against traumatic origin (save in sarcomata, which are more common in youth). Many authorities think that the tumors described as of traumatic origin are really latent, that is, that they are dormant until stimulated into activity by injury. On the point of aggravation of tumors by injury, Sand holds that this would be established under the following conditions: if the accident cause, directly or indirectly, a tear or a haemorrhage, etc., in the growth; if new symptoms of a serious nature show themselves within four days of the injury; if the development of the tumor was not at such a stage that an increase in activity was impending. A direct or indirect traumatism may induce in a tumor a breaking-up, and thus favor the production of metastases (the diffusion of the disease into other parts of the body), but it would most probably take a considerable time for these to develop, and their relation to the injury would be difficult to establish. An injury can not originate a metastasis in the wounded part, but it may favor the more rapid development of an existing metastasis. A question may arise as to whether in a state of general debility induced by an injury, the normal resistance of the body to the attacks of disease being thus diminished, malig- nant growths may evolve (apart from those which may properly be considered to have a relation to local trauma).? The answer to this question is, up to the present we have no scientific evidence to support the view that these growths arise under such cir- cumstances. The subject of chimney-sweeps ' cancer is briefly referred to by the same authority : Epithelioma of the scrotum in chimney-sweeps is believed to be due to the long-con- tinued irritation caused by the constant presence of soot on the part. The disease gives evidence of its maturity by the appearance of warty growths, which may remain quiescent or develop into ulcers. These ulcers progress and destroy the whole scrotum (purse). The glands in the groin become infected, and are eventually open, putrefying sores. The disease may ulcerate into the femoral or external iliac arteries and cause fatal haemorrhage. The disease is curable by early operative removal. Relation between Trauma and Tumor Formation The entire subject of malignant growths following injury, with special reference to claims arising from the result of such injuries, is discussed by Magruder in a treatise published in 1910.* The evidence presented is largely in the negative. He quotes Cohnheim to the effect that the "Statistics concerning the relationship between trauma and tumor formation are not convincing, as the tendency is too deeply rooted in the human mind to associate a local ailment with a local cause." He also quotes Williams, writing in the Twentieth Century Practice of Medi- cine, in the statement that "Those who maintain that cancers are com- monly caused by traumata, must explain how it is that men, who suffer three times as often from traumata as women, are, nevertheless, only about half as liable to cancers." This conclusion of Williams, however, would hardly seem warranted, since the fact is overlooked that the excess in cancer frequency among women is almost exclusively confined to the generative organs and the breast. Magruder quotes Sir Thomas Oliver's suggestion that "in all cases of alleged traumatic cancer leading to a fatal termination, a post-mortem examination should be made in order to ascertain whether what is apparent on the surface of the body is the primary or secondary growth." *"Claim9 Arising from Results of Pcrf-onal Injuries," W. Edward Magruder, M. D., The Spectator Com- pany, New York, 1910, 60 CANCER AND OCCUPATION Blast-furnace Pitch and Cancer The subject of blast-furnace pitch and cancer is briefly referred to in The British Medical Journal of August 19, 1911: Mr. Perkins asked the Home Secretary whether, in \-iew of the fact that the spread of cancer among workers with pitch was attributed to the anthracene contained in tar and pitch derived from gas works, whereas tar and pitch derived from blast-furnaces were free from anthracene, he would take this fact into consideration in the new Home Office regula- tions. Mr. Churchill repHed that the fact that blast-furnace pitch was much less liable to give rise to cancer was already recognized in the draft regulations, which had been issued by the Home Office, for the manufacture of patent fuel (briquettes) with the addition of pitch. Factories and workshops in which no pitch other than blast-furnace pitch was used were specifically exempted from the regulations. It was not, however, certain that anthracene was the constituent of ordinary pitch to which the prevalence of cancer in the industry was due. Malignant Disease of the Lungs in Miners An important contribution to the rather obscure subject of mahgnant disease of the lungs in the miners of the Schneeberg district of Saxony occurs in the Journal of the American Medical Association, under date of June 28, 1913: Arnstein calls attention anew to the remarkable prevalence of mahgnant disease of the lungs in the miners in the Schneeberg district in Saxony. The minerals mined are mostly cobalt, bismuth and nickel. In 1878 Harting and Hesse reported that a lymphosarcoma of the bronchial lymph-nodes or an endothelial sarcoma was responsible for 75 per cent. of all the deaths among the miners. Arnstein has been investigating the subject anew and found that one-third of all the miners admitted to the hospital 1907-1911 entered with the diagnosis of cancer of the lung, and it was given as the cause of death in 44 per cent, of the death certificates. It is probable that in many cases tuberculosis and possibly also pneu- moconiosis may have been erroneously diagnosed as cancer of the lung as necropsies are rare. The local mining industry is declining, and Arnstein urges more extensive study of the subject while there is still material for it. In the two cases which he was able to ex- amine post mortem, the trouble proved to be chronic pulmonary tuberculosis in one case, but in the other true carcinoma of the lung with metastasis. Cancer among Tar and Paraffin Workers The following observations on occupational cancers are from an address on "Occupational Diseases," by Dr. W. GUman Thompson, published in the Medical Record, New York, February 3, 1912: Tar and paraffin workers develop a similar eruption which may last several months and then change to the so-called "tar itch." This is accompanied by hyperkeratosis and in- creased activity of the sebaceous glands, forming plaques and crusts, with the further development of multiple warts, one or more of which degenerate into malignant growths. The disease aft'ects chiefly the hands, forearms, and scrotum. It progresses slowly and in many instances no recurrence takes place after removal of the epitheUoma. Oliver cites the case of a man aged 58 who had worked among coal-oil and tar products for thirty years. He presented numerous indurated patches, some of which had ulcerated, as well as multiple black warts and scars, the remains of old ulcers. His son, 27 years old, following the same employment, developed a malignant growth of the forearm which necessitated amputation. Metastases of the axillary and cervical lymph-nodes took place, the patient succimibing to secondary carcinosis. Cancer in chimney-sweeps has been reported chiefly from England. The soot produces a chronic irritation of the skin and when retamed in such regions as the folds of the scrotum causes warty growths which become epithehomatous. In some instances the hands, arms, and thighs have been involved. The incidence of scrotal cancer has been markedly reduced by the use of machinery to clean chimneys. It is reported that gardeners who employ soot for the protection of plants from slugs similarly show the effects of this irri- tant in the development of malignant growths of the hands. 61 THE MORTALITY FROM CANCER Comparative Mortality from Cancer among Chimney-sweeps Arlidge, in his work on "The Hygiene, Diseases and Mortality of Occupations," published in London in 1892, observes regarding chimney- sweeps' cancer:* But the disease, par eminence, attaching to their calling is epithelial cancer. Dr. Ogle discovered, from his statistics, that "of 242 deaths of chimney-sweeps, no less than forty- nine were due to some form of malignant disease. This gives 202 deaths from this cause to 1,000 deaths from all causes; whereas the proportion of deaths from malignant disease to deaths from all causes, among all males from 25 to 65 years of age in England and Wales, is only 36 in 1,000; so that, even if the total mortality of sweeps were simply equal to that of all males, their mortality from malignant disease would be more than five times as much as the average. But the mortality of chimney-sweeps . . . is 50 per cent, higher than the average, so that the liability of chimney-sweeps to mahgnant disease is about eight times as great as the average liability for all males. These figures scarcely support the belief expressed by some authorities that improvements in the art and habits of sweeps have caused this disease to be comparatively infrequent among them." Of the forty-nine cases of deaths by cancer returned, the scrotum and adjacent parts were the seat of the lesion in twenty-three; in thirteen the organ affected was not stated; but in seven of them the malady was in internal organs, and the rest in the face, hip, orbit, palate, or neck. The consoling belief that sweeps' cancer is becoming a scarce phenomenon, since the application of the special Acts of Parliament controlling their work, is also somewhat rudely shaken by Mr. Butlin, of St. Bartholomew's Hospital, who, in his work on cancer, aflBrms that numerous instances are to be met with. Cancer Frequency in Gardening and Agriculture An important reference to cancer as an occupational disease among gardeners occurs in the treatise on "Industrial Diseases," by Weyl, published in 1908. f This discussion refers particularly to market gardeners, and apparently leans towards the view that cancer is an infectious disease and transmitted to gardeners in connection with the handling of infected earth or water, as the case may be. There is also a reference in this discussion to the proportionate mortality from cancer among men employed in different occupations in the city of Berlin during the two years 1897-99, the percentage of cancer deaths in the mortality from all causes having been as follows: Printers, 3.18, chemical industry, 3.85, miners and stone-workers, 4.65, metal-workers,5. 08, machinists, 5.69, paper and leather industry, 6.18, wood-working industries, 6.45, com- mercial occupations, including insurance, 6.81, building, 6.96, clothing industry, 7.45, textile industry, 7.49, food industries, 7.67, transporta- tion industries, 8.08, shipping, 9.07, gardeners, 11.25, agriculture, 25.03. It is pointed out in this connection that in gardening and agriculture, respectively, 35.3 per cent, and 33.4 per cent, of the population are above age 40; but it is observed that this percentage is exceeded in many of the occupations in which the proportionate mortality from cancer is considerably less. Reference is also made in this work to the report of the German Com- mittee on Cancer Research, on the basis of the cancer census of Octo- ber 15, 1900. The proportion of patients suffering from cancer of the skin was found to be exceptionally large among agricultural workers, and the conclusion is advanced that this was the result of contact with infected earth. Mention is made of the rather interesting fact that the *An extended historical discussion of chimney-sweeps' cancer occurs in the chapter on chronic irritation, etc., in J. Wolff's treatise on Cancer, Vol. ii, p. 141, el seq. f'Handbuch der Arbeiterkrankheiten," Dr. Theodor Weyl, Jena, 1908, p. 625. 62 CANCER AXD OCCUPATION old garden city of Erfurt, with a constantly diminishing mortality from all causes, had experienced a constant increase in the mortality from can- cer. The rate per 10,000 living increased from 5.6 for the period 1880-84 gradually to 9.8 during the five years ending with 1904.* It was held, however, that this increase could not be connected with employment in gardening or truck-farming. Cancer in Animals and Plants In the study of the occupational incidence of cancer the possible para- sitical origin of the disease requires consideration. The subject has been quite carefully investigated by C. E. Green in his treatise on "The Cancer Problem: A Statistical Study," published in Edinburgh in 1911. Green has raised the question as to whether there are any conditions in the trades showing the highest cancer death rates which would encourage the growth of a parasite akin to the myxomycetes, which are of doubtful relationship either to animals or to plants. He tries to connect the cancerous growth in plants with the corresponding growth in the human body and in this connection points out that Agriculturists, however, have suffered severely from the ravages of Plasmodiophora and one fact in particular is given in agricultural text-books as the result of their practical experience, viz., that whenever manures are used which have been dissolved in sulphuric acid the disease is almost certain to occur. This fact seems very important. Of its ac- curacy there can be no doubt, since the Board of Agricultm-e goes so far as to distribute leaflets gratis all over the country warning farmers that manures dissolved in sulphuric acid have a marked tendency to encourage the disease. Coal-soot as a Cause of Cancer Green, therefore, concludes that such manures have a stimulating effect upon the plasmodiophora and that cancer is of exceptional frequency in occupations which encourage the gro^i:h of a possible cancer parasite under the conditions stated. He does not accept the mechanical irritant theory as entirely conclusive, but he inclines to the belief, with special reference to chimney-sweeping and similar occupations, "that soot, or some product of combustion, is an active agent." He, therefore, holds that Ordinary coal soot has a deleterious effect upon the leaves of plants, and this was formerly ascribed to mechanical irritation or to the blocking of the stomata through which the plants breathe. Stockhardt, however, proved this to be wrong by an experi- ment, eighty-six times repeated, in which he filled a glasshouse with an atmosphere of soot from burnt benzine so thick that the contours of the plants could not be seen, and that the leaves were almost black. No disturbance of growth could be detected, and the leaves were afterwards as fresh as those outside. The pure carbon soot from the benzine had no effect, while coal soot had. For- the same reasons he argues that the carbon in coal does not cause cancer in miners, which seems to be fairly well established by the avail- able statistics. In continuation of his interesting argument Green re- marks : The fact that coal soot has some relation to the sweeps' high mortality is also, I think, indicated by the part of the body chiefly affected, as shown by a table in the Registrar's latest report. This table shows that in 30 per cent, of the deaths the scrotum and its adjacent parts are those affected. Now, the face of a working sweep will always be found to be covered with light powdery soot, while his hands and nails are absolutely black and coated. The extremities are not liable to malignant disease, but these soot-ingrained hands must for ob^^ous reasons several times in a working day come in contact with the *The cancer death rate in Erfurt in 1910 was 12.0 per 10,000 of population. 63 THE MORTALITY FROM CANCER susceptible parts which are associated with "sweeps' cancer." If soot, then, be an active agent in producing mahgnant disease, as is shown by the appalhng mortality among chimney-sweeps and by other indications, while coal-dust has no effect upon the coal- miner, it is obviously of importance to consider what soot contains which coal does not. Green explains in this connection that coal-soot is chiefly composed of finely divided carbon, but that it contains also a considerable propor- tion of sulphate of ammonia; and further, that since coal contains sul- phur and nitrogen, sulphurous acid is evolved in the process of combus- tion, which combines to form sulphate of ammonia, the existence of which in large quantities in soot has led to its extensive use as a fertilizer by farmers and gardeners.* Paraflfin- workers Perplexed by the apparent difficulty that in sulphate of ammonia, or the sulphurous acid which goes to compose it, is a causative factor, it was difficult to explain how paraffin had induced cancerous growths among paraffin-workers in several well-authenticated cases. The question confronting him was to ascertain whether there was anything in common between commercial paraffin and soot. He observes with reference thereto: When we examine the practical methods of paraffin refining we find that in order to remove the oily bases it has been found in practice that an acid treatment of the finished oil is necessary. It is not possible to remove the whole of these bases by one or even two acid treatments, but the oil must be shaken vp with acids a number of times. All kinds of acids have been tried, but the results of numerous experiments have proved sulphuric acid to be the only one suitable for this work. It is specially pointed out in Redwood's Mineral Oils as of the utmost importance that all such sulphuric acid treated oils must be allov/ed to settle until as thoroughly freed from this acid tar as possible. In removing the impurities the sulphuric acid must form various sulpho-acids which must frequently be present in the paraffin after the operation. It would be a difficult matter to say what were the sulpho-acids, as there might be, of course, fifty different varie- ties, entirely depending on what the impurities were. There would certainly be no sulpho- acids of the paraffin itself, as this remains unacted on, and it is only impurities that are acted on. One impurity which is bound to exist, however, is ammonia — since the method of separation of ammonia water from the crude oil is a very rough and ready one — and we are driven to the result that even in refined paraffin, as in soot, sulphate of ammonia and sulpho-adds must often exist. Brewers These extracts have been given in full, since they are not only of in- terest in connection with the subject under consideration but also as an indication of the direction which scientific inquiries of this kind are bound to take. The conclusions by Green are apparently confirmed by his subsequent investigations, and particularly with reference to brewers, who exhibit a high mortality figure from cancer and who in a branch of their work are exposed to the effects of soot accumulations. Additionally thereto the brewer is said to be exposed in the constant handling of "sulphured" hops, the sulphur being used for bleaching purposes. *There is a brief reference to cancer in one of the papers on the "Influence of Smoke on Health," published by the Mellon Institute of Industrial Research, Pittsburgh, Pa., 1914. After restating the generally accepted view that "soot has for many years been more or less fancifully believed to create a predisposition towards the production of cancerous growth among workmen who are brought into contact with it" and an extended refer- ence to recent observations by Sir Thomas Oliver, the report concludes that "it is scarcely conceivable that the amount of soot in the air of industrial towns is sufficient in amount to be an exciting cause of cancer, as it might possibly be in the case of chimney-sweeps." (See, however, discussion of chemical industry, page 65.) 64 CANCER AND OCCUPATION Furriers and Skinners With special reference to furriers and skinners. Green calls attention to the instructive fact that these occupations rank high in the mortality from cancer, while tanners invariably rank very low. The cause, he ex- plains, must naturally be due to some essential differences in the method of preparing skins for furs and for leather. The facts are not fully set forth, but apparently the irritant is the sulphuric acid contained in the alum used for skin-preserving purposes. He remarks that nearly all furs have to be dyed, and that the mordant used is chiefly sulphuric acid. Seamen Concerning seamen it is said : Seamen have shown a great increase in their cancer mortality, due apparently to the increase of steamers and the decrease of sailing ships. The fact that they have a higher mortality figure than fishermen seems to me to be due to this and to their stuffy and smoky quarters. Fishermen do not so often sleep on board; indeed, the greater number never do. Tinplate-workers Concerning tinplate manufacture he observes : What element in the manufacture of tinplate can cause this very high mortality figure? If my theory is correct, this would explain it: "Before 'tinning,' the plates are called black plates. When the iron has been cut to the required size the plates are 'pickled,' i. e., they are immersed in hot sulphuric acid." Lead-workers Also with reference to lead-workers the observations are of special interest : Here we have a close connection with sulphurous acid. It is pointed out in the last report of the Registrar-General that the mortality of lead-workers had decreased since 1890. Now, until recent years only a small quantity of lead was obtained from any other ore than galena, which is a sulphide of lead. \Mien galena is smelted, much of the sulphur goes to form sulphurous acid, which escapes as a gas. There remain in the hearth of the furnace oxide, sulphate, and sulphide of lead, which react upon each other, forming sulphurous acid and metallic lead. Rubber- workers And concerning India rubber-workers: The connection here is at first sight obsciu-e, but the fact remains that alum and sulphuric acid are constantly used to effect the coagulation of the juice, and it is pointed out in the Encyclopedia Britannica (India rubber) that traces of these remaining in the rubber constantly work mischief in it. Chemical Industry Green's treatise includes a brief discussion of the incidence of cancer in chemical manufactures, which, of course, include employments with an exceptional degree of exposure to sulphuric acid fumes, etc., and as re- gards general occupations in London, for which the mortality figure is above the average, he explains that this is probably due to the enor- mous amount of sulphurous acid in the atmosphere. He incidentally mentions the frequency of cancer among guano-workers, quoting from the new edition of Bryant and Buck's Surgery, the occurrence being at- tributed to the fact that since the rich deposits have been largely worked out the stores now drawn upon are, in many cases, compact and rocky in texture, and require to be disintegrated and treated with sulphuric acid. He therefore concludes that "if sulphurous acid or sulpho-acids 65 THE MORTALITY FROM CANCER have no connection with cancer I have stumbled across an extraordi- nary series of coincidences." X-ray Workers and X-ray Dermatitis Perhaps no problem in occupational cancer has attracted more atten- tion than X-ray carcinoma. An analysis of forty-seven cases is pre- sented by Dr. C. A. Porter, of the Harvard Medical School, in the Fifth Report of the Cancer Commission of Harvard University. The fol- lowing brief observations are from this important contribution to the subject : Though the harmful results of continuous exposure to the X-rays were unknown to the early workers in this field, it would seem that unwittingly they have given us the best demonstration yet known of the artificial or experimental production of cancer. It is unlikely that old age itself, with its accompanying skin atrophies, even if combined with exposure to such various noxious influences as sea life, raw winds, powerful actinic rays, soot or paraffin, would give such an example of malignant skin degeneration as seems so frequently to result from protracted exposure to the X-ray. ^Mien it is remembered that these lesions have been produced in young men at an age when skin cancer is extremely rare, its occurrence is all the more striking. Regarding an apparently effective method of protection for X-ray workers it is said: An accidental discovery in the case of J. G., Case XVIII., seems to show the value of protection during the early years of work, and the lack of harmful influence to recent exposures with proper precautions. A broad gold ring was worn during the first two years of work on the ring finger of the left hand. This was subsequently removed. The whole dorsum of the hand shows the characteristic changes, while the skin protected by the ring remains to this day perfectly normal. The immunity which even fight clothing offers is shown by the rarity or slight degree of dermatitis above the cuffs, and in those parts of the body protected by clothing. It would seem, therefore, in view of this immunity from slight covering, that not the X-rays themselves, but other emanations from the tube are to be held chiefly responsible for the burns and the chronic dermatitis. The subject attracted the attention of Green, who remarks; In this imperfect survey of the trade and occupational incidence of the disease I would venture to make a suggestion regarding what is caUed X-ray cancer, which so commonly follows a dermatitis on the hands of X-ray workers. It is certainly one of the most puzzfing aspects of the whole cancer problem that X-rays should cure rodent ulcer and yet induce epithelioma on the fingers of the operators of these rays. If, as stated before, the Plas- modia of myxomycetes are killed by exposure to light of moderate intensity, it is quite intelligible that X-rays should cure cancer, but quite iminteUigible that they should cause it. The X-rays admittedly cause a dermatitis and thereby diminish the resistance of the epithefium. It should not be forgotten, however, that most X-ray operators have to prepare many skiagraphs and to develop negatives. This, in my opinion, is the cause. Fixing plates by means of hypo-sulphite with fingers, the skin resistance of which is already weakened, is much more likely to cause the epithelioma than the rays themselves. These would only indirectly be concerned. As bearing upon the protective means suggested by Dr. Porter it appears that Dr. Menard, director of the radiography section of the Cochin Hospital, has devised a glove which will avert all danger to the operating physician when using the X-ray. It would carry this discussion entirely too far to review in detail the not inconsiderable evidence of Roentgen-ray injuries, with reference, of course, to cancer growth. The risk, no doubt, is especially great in the manufacture of X-ray appa- ratus, and particularly X-ray tubes. The subject has been discussed under the title "Roentgen-rays and Dermatitis," by Sir Thomas Oliver in his evidence (Q. 10,625), before the Committee on Industrial Diseases. 66 CANCER AND OCCUPATION In view of the obvious risk to X-ray workers, the following extract from the Medical Record of August 8, 1903, is included: G. Holzknecht and R. Griinfeld have devised a protective covering for the skin for use during the application of the Roentgen rays. It consists of a sheet of tin which is covered on both sides with a thin layer of hard rubber. The plate thus made may be of any size and shape desired and perforated by as many apertures as wished. It is very flexible and may be easily adapted to the various curvatures, etc., of the body. It is light and easy to handle, and may be sterilized, washed, or heated without damage. Its extended use shows that it affords a complete protection to the healthy skin from the burning and other armoyances which frequently attend the appUcation of the Roentgen rays. Among the more suggestive cases of fatal injuries from X-ray expo- sure in the medical profession a brief reference may be made to the death of Dr. B. E. Baker, of Hartford, who died from injuries due to exposure to the X-rays in the course of experimental work in 1913. The Medical Record of March 29, 1913, quoting from the Journal for Insurance Medicine * notes the case of an electrician as follows : The electrician was employed for fifteen years in the X-ray room of an orthopedic clinic and had suffered from a chronic affection of the skin of the hands and face resulting irom constant exposure to the rays. He was finally incapacitated, and applied to his trade union for the indemnity for accidental injury during employment. The union refused such indemnity, stating that the injury complained of was not due to any accident, but was really an occupational disease, not to be indemnified according to the terms of insurance. An appeal to the courts was decided in favor of the union's interpretation of the agreement. The Medical Record also, under date of April 5, 1913, cites the case of the death of Dr. Charles Lester Leonard, professor of Roentgenology in the Philadelphia Polyclinic and College for Graduates in Medicine, and one of the pioneers in this special field of work. Dr. Leonard some years ago first lost several fingers from one hand, and later on the entire hand was sacrificed, it being subsequently found necessary to remove the forearm so as to check the advancing effects of the X-ray burns. Radio-active Substances and Cancer The study of radio-active substances in their relation to cancer and occupation offers a field of considerable promise. The admirable ex- perimental inquiry by Lazarus-Barlow suggests results of considerable practical value. With regard to substances commonly supposed to be casually related to carcinoma, this author states that Numerous samples of clay pipe, soot, pitch, paraffin wax, metallic arsenic, arsenious oxide, betel nut, cholesterin gall stones, pigment gall stones, renal and vesical calcuH, have been examined skotographically, the calcuh, renal, bihary, and vesical, being made the subject of an extended research by Dr. Colwell. Skotographic effect was exhibited by one sample of soot out of two examined, by betel nut on all of numerous occasions, by each of twenty-three specimens of cholesterin gall stones, more or less "pvu-e," in three out of four samples of pigment gall stones examined, the effect being always very slight as com- pared with the action of the cholesterin calcuh, and by thirty out of thirty-eight vesical calcuh. Metalhc arsenic and arsenious oxide produced effects upon the photographic plates, but inasmuch as the films showed alteration before development the action cannot be regarded as skotographic. On the other hand, none of nine specimens of clay pipe, of numerous samples of paraffin wax, of four samples of pitch from different localities, of several specimens of coal, yielded the sUghtest trace of skotographic action. f Even though the evidence was negative, it would seem well worth while to carry on further experimental research along the lines suggested. *Zeitschrift fiir Versicherungs Medizin, Vol. v. No. 12, XThe BritUk Medical Journal, June 19, 1909. 67 TEE MORTALITY FROM CANCER Cancer and Exposure to Light The relatively high frequency of cancer among seamen and fishermen would seem to support the theory advanced by Wilfred Watkins Pitch- ford, M. D., Government Pathologist of Natal, in an address on Light Pigmentation and New Growth, in which the view is advanced that The increase of cancer within the last seventy-five years is perhaps due to the dimin- ished protection from light and increased exposure to illumination. Woolen garments have been largely replaced by cotton, and black and brown clothes by those of a light color. Narrow streets and dark houses are no longer tolerated and suburban life has largely replaced that of the city. Artificial light has become more actinic in its character. He further concludes, as a manifest deduction from the foregoing principles, that cancer may be prevented by eflBcient protection of the body from light and that natural protection, such as hair upon the face, should be encouraged. The clothing should be absolutely light-proof. The ventral surface of the thorax and abdomen should be especially protected. Considering the almost universal non-protection of the upper chest of many women at the present time, the conclusion of this author to the effect that "Mammary cancer in women is usually due to insufficient protection of the breast from light" may be quoted as a word of warning. The theory of Dr. Pitchford also suggests an explanation, at least in part, why the dark-skinned races should apparently be so much less liable to malignant disease than the white races liv- ing in tropical or non-tropical countries. The author's complex and involved theory which underlies the practical application of the prin- ciples of actinic therapy can not be discussed in detail.* The Synthetic-dye Industry The foregoing discussion is but an inadequate outline of an important branch of industrial medicine. The subject is as yet in its initial stage and few really substantial contributions have been made to the scientific study of the facts. What may be considered a classical contribution to the problem is an essay on the effect of the synthetic-dye industry on the occurrence of tumors, by Dr. S. G. Leuenberger of Zurich, published in the Contributions to Clinical Surgery for 1912. f The thoroughness of this investigation is best emphasized in the statement that the literature cited includes 318 titles. There can be no question of doubt that further specialized cancer research in conformity to this method and particularly in the chemical trades would yield exception- ally useful results. Another valuable contribution to the same subject is an extended discussion of the so-called Schneeberg carcinoma of the lung, by Alfred Arnstein of Vienna, first described by Harting and Hesse in 1878-79. This form of cancerous growth, as previously pointed out, occurs among miners in the Schneeberg District of Saxony, the minerals mined being nickel, cobalt and bismuth. The disease is con- sidered to be exceptionally common where, in damp shafts, there are extensive growths of vegetable molds, which fact, suggests a possi- ble application in the present case of the theory advanced by Green * "Light, Pigmentation and New Growth," by Wilfred Watkins Pitchford, M. D., F. K. C. S., Natal, The British Medical Journal, August 21, 1909. t "Die unter dem Einfluss der synthetischen Farbenindustrie beobachtete Geschwulstentwicklung," by Dr, S. G. Leuenberger Beitrage zur Kliniachen Chirurgie, Tubingen, 1912, 68 CANCER AND OCCUPATION of Edinburgh, elsewhere discussed in this section. The dissertation by Arnstein was first delivered before the German Pathological Society in 1913, and printed in full in the Clinical Weekly of Vienna, under date of May 8, 1913.* Finally, a brief reference requires to be made to the extended dis- cussion of pitch ulceration and chimney-sweeps' cancer, etc., in the report of the Departmental Committee on Industrial Diseases (1907), which includes a reprint of the comparative cancer occupation mortality tables for England and Wales. The Tinplate Industry Quite recently an investigation has been made into the frequency of cancerous complaints among persons employed in the manufacture of tinplates, and a brief reference thereto occurs in a report on the "Process of Tinning," published by the Factory Inspection Department of the United Kingdom in 1912. The reference reads: The danger of long standing indigestion, which indicates a chronic inflanamatory condition of the gastro-intestinal tract cannot be overlooked; moreover, Victor Bonney expressed the opinion that the onset of carcinoma is constantly preceded by certain chronic inflammatory changes; and such evidence as is obtainable' goes to show that tinhouse operatives die in excess from gastro-intestinal disease, of which cancer is the chief. The subject was further investigated by the laboratories of the John Howard McFadden Research Fund of the Lister Institute of Preventive Medicine. In a joint report on the results of an investigation of the chronic irritation caused by fumes and dust produced in the process of manufacturing tinplate, by Messrs. Ross and Cropper, published in The Lancet under date of August 9, 1913, it is stated that In the process of tinning fumes are given off which have a powerful irritating effect on the mucous membrane, and it is with a view to finding out whether these fumes contain auxetics and kinetics that this research has been undertaken. At the pitch works the pathological lesions are confined to the eyes and skin, but in the tinplate works the skin remains unaffected, and it is only in the naso-pharyngeal and alimentary passages that the irritation is felt. The technique and the details of the experiments are briefly de- scribed in the article, but more fully in the report previously referred to on the problem of gas-works and pitch industries and cancer, published by the same Fund in 1912. Apparently cancerous lesions are produced by irritating fumes and dust in the tinplate industry in much the same manner and to much the same extent, perhaps, as in the manufacture of artificial fuel briquettes. The results of the investiga- tion were not entirely conclusive, but in the meantime it was considered advisable to suggest methods and means tending to alleviate the con- ditions at the tinplate-works. It was therefore proposed by the authors that a substitute or substitutes should be employed for the palm oil used, such as mineral oil or wax or any suitable substance which would be auxetic-free, and which when mixed under the industrial condi- tions with a flux would continue to be auxetic-free. It was suggested that a suitable substitute be tried for the flux, or it may be found more practicable to treat the palm oil or flux, or both, by re-agents in order to oxidize the auxetics or to fix them by the Sorenson reaction. Further, it may be ad\asable to separate the stages of the process of tinning by suitable covering of the various parts of the process or by isolating the workmen. *"Ueber den sogenannten 'Schneeberger Lungenkrebs'," by Dr. Alfred Arnstein, Wiener klinische Wochew schrift, Wien, May 8, 1913. 69 TBE MORTALITY FROM CANCER In concluding these general observations on the occupational incidence of cancer, the following brief statement from "The Pathology of Growth," with special reference to tumors, by Charles Powell White, published in New York, 1913, is of interest: Chemical substances derived from the outside in the course of various occupations may play a part in cancer causation. Workers in soot, tar, parafiSn, and the like sometimes develop carcinoma of the skin, which must apparently be attributed to their occupation. In the case of chimney-sweeps the usual seat of the tumor is the scrotum. Tar and paraffin workers may develop carcinoma of the scrotum or of the arms or other parts. Arsenic may give rise to a chronic eczema which may be followed by carcinoma. Workers in certain nickel and cobalt mines are said to be Uable to lymphocytoma of the mediastinum, and workers in dye works where aniline is largely used are liable to cancer of the bladder. The evidence brought together would seem to be quite suflScient to sustain the conclusion that the occupational incidence of cancer is an important phase of the larger problem of cancer frequency and that specialized investigations in this direction are quite likely to yield results of far-reaching practical importance. Statistics of Cancer in Relation to Occupation The most useful statistical data regarding the occupational incidence of cancer are those published at decennial intervals in the supplement to the aimual report of the Registrar- General for England and Wales. The statistics for the two three-year periods ending with 1892 and 1902 have been brought together in a convenient form for the principal occu- pations in the tables appended to this discussion. The data for the three years ending with 1912 will not be available for several years. Tables 1 to 5, inclusive, in Appendix C, give the number of persons employed in particular groups of occupations, or, more accurately, the total num- ber of years of life exposed to risk. The actual number of persons con- sidered is in each case approximately one-third of the number of years of life for the three-year period. The tables also give the total number of deaths from cancer during the three-year period and the cancer death rates calculated on a uniform basis of 100,000 of population. The titles of the tables in Appendix C, including the occupation mortality statis- tics of The Prudential are given below: Table 1 — Mortality from Cancer in England and Wales, in selected occupations, according to age, males, 1890-92. Table 2 — Mortality from Cancer in England and Wales, in selected occupations, according to age, males, 1900-02. Table 3 — Mortality from Cancer in England and Wales, in selected occupations, males, crude and standardized death rates, ages 15 and over, 1890-92. Table 4 — MortaHty from Cancer in England and Wales, in selected occupations, males, crude and standardized death rates, ages 15 and over, 1900-02. Table 5 — MortaUty from Cancer in England and Wales, in selected occupations, males, ages 15 and over, standardized death rates, 1890-92, compared with 1900-02. Table 6 — Industrial experience of The Prudential Insurance Company of America, Mortality from Cancer, by occupation, ages 35 and over, males, 1907-12. 70 CANCER AND OCCUPATION Table 7 — Cases of Cancer in Hungary, by occupation, 1904. Table 8 — Mortality from Cancer in Hungary, by occupation, 1901-04. English Mortality Statistics On account of the limitations of space the following b'rief observations have reference only to the mortality from cancer in selected occupations, ages 15 and over, as determined by the crude and standardized death rates of England and Wales for the three years ending with 1902 (Table 4, Appen dix C) . Since the cancer death rate is in vari ably a function of age, it is obviously of the utmost practical importance that in the calculation of cancer mortality rates by occupation the age factor should, if possible, be taken into account. Some occupational groups include a much larger proportion of persons of the cancer age than others, as is, perhaps, best illustrated in the contrast of clergymen and persons employed in clerical occupations (bookkeepers, clerks and copyists). Among clergy- men, according to the United States Census for 1900, the proportion living at ages 45 and over was 45.5 per cent., compared with a corre- sponding proportion for clerical occupations of only 14.1 per cent. The crude cancer death rates based upon occupational groups so funda- mentally at variance with each other as regards age distribution are practically certain to be erroneous and, as a rule, seriously misleading. In the English experience for 1900-02, for illustration, the crude cancer death rate for clergymen was 163.1 per 100,000 of population, as com- pared with a rate of only 5^.5 for school teachers. When, however, the required standardization is made for age, the rates for the two groups are brought into close conformity to each other, the rate being, for clergymen, 87.3, and for school teachers, 90,1. An equally striking result is obtained by means of the standardization for age in the cancer death rate of English railway engine-drivers and stokers, for which the crude death rate of 41.9 per 100,000 of population is increased to a standardized death rate of 85.3. When thus standardized for age, the relative incidence of cancer in dif- ferent occupations becomes a reasonably trustworthy indication of the specific liability to cancer in certain employments, although a further correction for the organs and parts of the body affected would be necessary to establish the true causal relationship existing between specific employments and specific forms of malignant growth. The table referred to (Table 4, Appendix C) shows, first, the recorded cancer death rate per 100,000 of population, second, the factor for stand- ardization as determined by the variations in the age distribution of the different groups and, third, the resulting standardized death rate, which alone can be considered conclusive for the purpose of comparison. This table brings out the fact that the highest standardized cancer death rate occurred among chimney-sweeps, for which occupation the rate was 224.9 per 100,000 exposed to risk. The rate for seamen was 170.5, and for brewers, 166.6. Relatively high, but not abnormally excessive, cancer death rates are met with in the following occupations: fishermen, 111.9, tailors, 112.9, textile-workers, 112.6, lawyers, 111.8, innkeepers, 108.8, corn-millers, 105.3, gas-works service, 107.1, shoemakers, 103.2, and butchers, 102.8. Lower cancer death rates but still suggestive of special predisposing conditions are met with in the following occupations: 71 TEE MORTALITY FROM CANCER farmers and graziers, 94.8, farm laborers, 79.7, and gardeners and nurserymen, 85.2. In a general way the relative degree of occu- pational cancer frequency as disclosed by the analysis of the stand- ardized death rates for 1900-02 is confirmed by the previous investi- gation for the three years ending with 1892 (Table 3, Appendix C). The wide variations in occupational conditions suggest the existence of causative factors rather than of a single cause as being responsible for the exceptional cancer frequency in certain occupations; but the most suggestive result of this analysis is the evidence of an un- usually high mortality from malignant disease in three specific though widely difterent employments, namely, chimney-sweeps, seamen and brewers. It is equally suggestive that relatively high cancer death rates should have been experienced in more or less unrelated occupations, i. e., maltsters, fishermen and persons employed in the gas-works service. It is regrettable that these statistics should be so largely for groups of employments rather than for specific occupations. But this conclusion does not apply to the three principal employments with excessive cancer death rates, i. e., chimney-sweeps, seamen and brewers. It is quite probable that if certain employments in the gas-works service could have been separately considered, the cancer death rate of such a selected group would have been found to be much higher than that of the indus- try as a whole. The several tables in the Appendix are well-deserving of extended critical consideration. The English data are the most trustworthy and conclusive available for the present purpose, and the suggestion may be made that as far as practicable a corresponding analysis should be made of the occupation mortality data for the regis- tration area of the United States on the basis of the occupation statistics of the thirteenth census. Life Insurance Experience Data The frequency of cancer according to occupation in the experience of life insurance companies has not been made the subject of a special study otherwise than as disclosed by the medical statistics of The Prudential Insurance Company of America, first exhibited on the occa- sion of the Fifteenth International Congress of Hygiene and Demog- raphy. It is regrettable that this experience could not have been correlated to the exposed to risk in different occupations, but such an extension of the statistical analysis could have been made only at con- siderable expense, without the assurance in advance that the practical results would be commensurate with the cost. The statistical tabulation is therefore limited to the deaths from cancer by occupations, ages 35 and over, correlated to the mortality from all causes at corresponding periods of life. This method of proportionate mortality analysis is of consider- able practical usefulness. It is shown that the highest proportionate mortality from cancer, 12.32 per cent., was experienced among coal- dealers, followed by teachers, 11.35 percent., editors and journalists, 9.90 per cent., laundrymen, 8.62 per cent., upholsterers, 8.44 per cent., gar- deners, 8.43 per cent., brewers and maltsters, 5.78 per cent., clergymen, 8.00 per cent., engineers (not specified), 7.90 per cent., sawyers, 7.65 per cent., clothing-workers (tailors), 7.49 per cent., plasterers, 7.10 per cent. 72 CANCER AND OCCUPATION Limitations of Occupational Mortality Statistics These statistics are not conclusive and should be accepted with caution. They show, for illustration, that tanners, who in the English experience had a low mortality, had in the Prudential experience a comparative figure of 6.02 per cent., against 5.78 per cent, for brewers and maltsters. How far the element of medical selection affects these data is rather doubtful. The medical examination required for Industrial insurance purposes is generally not very thorough, but it would be apt to be more thorough in the case of brewers and maltsters, as well as in the case of persons otherwise connected with the ale, wine and liquor traffic, than of those not so employed. The statistical tables are, therefore, pre- sented with some reluctance, and they are to be rather considered as a preUminary contribution towards a more scientific and thoroughly representative inquiry into the facts.* Thus far no cancer occupation mortality data derived from life insurance experience have concisely differentiated the organs and parts of the body affected. As brought out by the previous discussion, the possible local irritant responsible for cancer growth must necessarily be limited to the particular parts of the body more exposed than others, on account of special occupational activi- ties. The frequency of cancer of the scrotum in chimney-sweeps and of cancer of the urinary organs in persons employed in the manufacture of aniline dyes suggest the practical value of a more specialized statisti- cal investigation in this field. Iiritability and Cancer Causation The foregoing brief discussion of an important phase of the cancer problem emphasizes the urgency of more extended occupational studies than have thus far been made. Cumulative evidence would tend to establish the truth or the falsity of prevaiUng opinion and, in any event, eliminate much misleading information. The fundamental concept of irritability as the direct or contributing cause of cancerous growth is apparently well sustained by occupational studies of the cancer problem. f All disease, it is held by the foremost author on irritability, or the effect of stimuli in living substances, "consists of the influence of stimuli upon these physiological processes." "Every disease," he maintains, "repre- sents only a disturbance of the physiological processes of cell life of the organism and the harmony in their combined workings." Believing that the available evidence regarding cancer warrants the conclusion that malignant disease is not the result of a single cause, I can not do *Iii this connection the following sources of information on cancer occupation mortality statistics should be consulted: Ueber den Einfluss von Beruf und Lebensstellung auf die Todesursachenin Halle, a. S., 1901-09. Recueil de Statistique Municipale de la ville de Paris, Dr. Jacques Bertillon, IQl^. Ungarische Statistische Mitteilungen; Statistik der Krebskranken in den Landern der L'ngarischen Heiligen Krone, 1908. Bericht ueber die vom Komite fur Krebsforschung am 15 Oktober, 1900, erhobene Sammelforschung, Jena, 1902, Das Vorkommen des Krebses in Baden, Dr. R. Werner. The morbidity and mortality experience of the Leip- zig Communal Sick Fund, Berlin, 1910. Mortality Statistics, 1908-09, Division of Vital Statistics, Bureau of the United States Census. tThe technical aspects of the problem of causation or conditioning circumstances from the pathological point of view have been discussed by Gustav Heim in Virchow's Archiv., Vol. ccxvi, Berlin, 1914. The philo- sophical aspects of causation are fully discussed by Stanley Jevonsin his "Principles of Science" (Vol. i, p. ioi, et seg.), who observes that "the work of science consists in ascertaining the combination in which phenomena present themselves," which is precisely the object and proper use of the statistical method in cancer research. See also in this connection Pearson's "Grammar of Science" ('2d edit., p. 113, et seq.), and John Stuart Mill's "Logic" (New York, 1891, 8th edit., p. 311), on 'Tlurality of Causes," who observes, inter alia, "It is not true that the same phenomenon is always produced by the same cause." 73 THE MORTALITY FROM CANCER better than conclude by quoting the following most carefully consid- ered remarks of Dr. Max Verworn, the author of a standard work on "Irritability": Another point concerning the application of the conception of cause seems to me, however, to be of much more importance, namely, that a single cause is held responsible for the taking place of a process. One endeavors to explain a process in general by seeking for its "cause." The cause being found, the process is considered fully accounted for. This idea is not one widely spread in everyday Hfe, but is found frequently in natural science, especially in biology, although here, it should be known, the processes are decidedly more complicated. The search for the "cause" of development, for the "cause" of hered- ity, for the "cause" of death, for the "cause" of the respiration, for the "cause" of the heart beat, for the "cause" of sleep, for the "cause" of disease, etc., was for a long time and frequently even to-day a characteristic of biological investigation. As if such a compli- cated process as development, death or disease could be explained by a single factor! In reality, one has obtained very little as a result of the analysis of a process by discovering its cause; and, in addition, the false impression arises that through the finding of this one factor the process has been definitely explained. It has been generally recognized in the natural sciences in recent times that no process in the world is dependent upon one single factor and attempts have been made to give this fact more consideration. This conclusion applies with special force to the cancer problem and provides the best possible answer to the constantly recurring question as to the cause of cancer and its direct relation to the larger problem of prevention, treatment and control.* Foreign Cancer Census Investigations The scientific study of the occupational incidence of cancer has been attempted with more or less success by means of special cancer censuses, the results of which, however, as a rule, have not been correlated to the living population with a due regard to age and sex. These investiga- tions can not be fully discussed here, but they are referred to briefly as an indication of the direction of research work, which is likely to prove of considerable practical value. The German cancer census of 1902t presents the collected cancer cases, by occupations, according to sex, for the empire as a whole, and for the large cities separately, and also with reference to organs or parts of the body affected. The investigation considered only those suffering from the disease who were actively employed, or employable, or, in other words, persons in the advanced stage of the disease were apparently ex- cluded. The table below gives the details for certain broad divisions of occupations, and while not conclusive, the facts are certainly suggestive. Cancer in Germany, by Organs and Parts, according to Occupation, Males All Textile Metal Wood- Trans- Occupa- Agri- Manufac- Common Work- working porta- Organ or Part tions culture ture Laborers Retired ers Industry tion Bones 25 21 19 21 20 30 41 23 Skin 150 250 99 140 163 90 110 112 Respiratory organs.... 20 7 19 16 24 30 21 14 Digestive organs 703 642 783 718 703 750 685 748 Urinary organs 15 8 .. 10 45 30 13 6 Glands 59 54 53 56 28 35 96 70 Breast 4 1 .. 2 4 15 13 9 Generative organs 24 17 27 37 13 20 21 19 Total 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 *See discussion of Cancer in Selected Occupations, Bulletin of American Academy of Medicine, 1914. tBericht ueber die vom Komite fur Krebsforschung am 15 Oktober, 1900, erhobene Sammelforschung, Jena, 1902. 74 CANCER AND OCCUPATION Cancer in Germany, by Organs and Parts, according to Occupation, Females All Textile Restau- Do- Occupa- Agri- Manufac- Common rant, etc., Laun- mestic Organ or Part tions culture ture Laborers Retired Keepers dresses Service Bones 11 18 10 11 10 .. 8 20 Skin 73 151 52 95 88 .. 116 81 Respiratory organs .... 3 .. 5 4 Digestive organs 306 338 235 374 311 244 349 323 Urinary organs 6 4 10 4 4 .. .. 10 Glands 55 73 26 54 38 122 16 61 Breast 243 208 287 154 374 220 240 111 Generative organs 303 208 375 304 175 414 271 394 Total 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 As an illustration of the value of this method of statistical analysis the excessive relative incidence of cancer of the skin in agriculture may be re- ferred to, the proportion among males having been 25 per cent, of all cancers, against only 9 per cent, for workers in the metallic industries and 11 per cent, for workers in the wood- working industries. The same pronounced differences regarding the incidence of cancer of the skin appear among female workers, the proportion for those in agriculture having been 15.1 per cent., against only 8.1 per cent, for domestic service. Tables of this kind, however, require to be standardized for variation in age distribution, which, unfortunately, is not possible on the basis of the data as derived from the German cancer census.* The occupational incidence of cancer was also reported upon in the Hungarian cancer census, published in 1908. f This investigation is limited to males in specified industries correlated to the population as determined by the general census. The data are subjected to a check through a subsequent analysis of the cancer mortality by occupations for the period 1901-04. | The highest relative cancer figure was for day laborers, 13.66 cases per 10,000 employed, followed by butchers, with 11.57, and independent traders, with 9.27. In a general way, the data ascertained by the cancer census were confirmed by the mortality analysis, but there are important variations, due, no doubt, largely to the varying age distribution of the different occupational groups, which unfortunately could not be taken into account. As an illustration of the relative inci- dence of cancer in the more important groups of occupations, it may be pointed out that while day laborers experienced a cancer morbidity rate of 13.66 per 10,000, the corresponding rate for the mining in- dustry was only 3.37, and for agriculture, 1.74. As brought out by the mortality analysis, day laborers experienced a rate of 8.66 per 10,000, the mining industry, 4.81, and agriculture, 4.59. These differences are so pronounced that they warrant the conclusion that really use- ful and conclusive investigations into the occupation incidence of cancer require to be made with a due regard to the age distribution of the *The experience data of the Leipzig Communal Sick Fund are valuable tor general purposes, but hardly conclusive regarding the comparative incidence of cancer in different occupations. For all compulsorily in- sured males the cancer death rate per 100,000 of population at ages 15-24 was 1.1 ; at ages 25-34, 3.4; at ages 35-44, 23.1; at ages 45-54, 100.1; at ages 55-64, 215.7; at ages 65-74, 375.5; and at all ages, 24.4. For those insured voluntarily the rates throughout were much higher, and for all ages combined the mortality was 196.6. For females the numbers exposed to risk are much less and the data are obviously inconclusive. fStatistik der Krebskranken in den Landern der Ungarischen Heiligen Krone, Budapest, 1908. tTables 7 and 8, Appendix C. 75 THE MORTALITY FROM CANCER persons employed and the organs and parts of the body affected by can- cerous growths. The incidence of cancer among women, according to occupation, is also briefly considered and the facts, presented in detail, are deserving of more attention than they have received in the past. A very important contribution to the statistical study of cancer, with particular reference to occupation, social condition, etc., was published in 1904 in the "Journal of the German Society for Cancer Research." This investigation was made by a commission of the Medical Society of Stuttgart. The authors of the report were Drs. Weinberg and Gastpar. Investigations of this kind emphasize the extremely complex nature of the cancer problem statistically considered, and the conclusion that the intricacy of causal connection of the phenomena under observation in- creases in proportion to the number of separate circumstances or condi- tions subjected to critical analysis. Another important occupational study, with a due regard to organs and parts of the body affected, occurs in the Swedish cancer census of 1905-06, published in the "Journal of the German Society for Cancer Research" for 1909. Karl Kolb, Secretary of the Cancer Society of Bavaria, contributed an instructive discussion of the relation of occupation to cancer, reduced to a uniform basis of a normal population with a due regard to age, to the "Journal of the German Society for Cancer Research" of 1910. This investigation includes some interesting data regarding the cancer inci- dence among nuns and nurses, but unfortunately the statistics were not reduced to rates on the basis of the living population. Many of the tables in this and other investigations would have been materially increased in value, if the data had been given by divisional periods of life, and in all cases by the organs or parts of the body affected. Requirement for Scientific Statistical Research The material brought together by these and other investigators has not received the required amount of qualified and strictly impartial con- sideration. It would seem useless to encourage statistical research of this kind unless there is more conformity to practical and standardized methods of inquiry. It would also seem much better to select a carefully chosen group of specific occupations apparently subject to an excessive incidence of cancer, or more or less relatively free therefrom, and to rigor- ously examine the details of the experience, with a due regard to the age distribution of the persons considered and the organs and parts of the body affected. If such an analysis were made of the cancer mor- tality of workers in agriculture, gardeners, florists, brewers, etc., known to be subject to a high cancer mortality, and tanners, miners, etc., known to be subject to a low or at least normal mortality, the results would be unquestionably of much value to the medical and surgical profession, as well as to those employed in the particular occupations considered. The present study must be considered inconclusive from this point of view, except in so far as it has been shown that there are unquestionably certain industries which make the persons employed therein distinctly liable to cancerous growths in varying forms, and that res'ults of far-reaching value to the cancer problem as a whole may be derived from a more scientific study of the occupational incidence of cancer than has thus far been made. 76 CHAPTER V CANCER AS A PROBLEM IN LIFE INSURANCE MEDICINE Cancer in the Literature of Life Insurance Medicine — Early Life Insurance Experience Data — Discussion of Scottish Widows' Fund Experience — Observations Regarding Cancer Increase — Experience of American Life Insurance Companies — German and Austrian Insurance Experience — Medico- Actuarial Investigation — Family Historj' — Effect of Build and Conjugal Condition — Cancer of Breast and Generative Organs among Single and Married Women — Experience of The Prudential Insurance Company of America — Cancer as a Life Insurance Problem. Cancer in its relation to life insurance presents itself in a threefold aspect: first, as a problem in medical selection or insurance medicine, second, as an element in insurance experience, and third, as a question of state medicine, with a special regard to the educational value of cancer statistics and the feasibility of cancer control. The importance of the problem is set forth in the statement that the approximate mortality from cancer in the Continental United States for 1915 is over 80,000. Considered by organs and parts of the body affected, the estimated* mortality for 1915 is as follows: Estimated Mortality from Cancer, by Organs and Parts, in Continental United States, 1915 Organ or Part Deaths Per Cent. Buccal cavity 3,152 3.9 Stomach and liver 31,672 39.6 Peritoneum, intestines, rectum. . . . 10,616 13.3 Female generative organs 12,344 15.4 Breast 7,360 9.2 Skin 2,760 3.5 Other or not specified organs 12,096 15.1 80,000 100.0 For the year 1910 the average age at death from cancer and other malig- nant tumors combined was 59.2 years for the registration area of the United States. For males the average age at death was 60.4 years and for females, 58.4 years. The average age at death in cancer of the buc- cal cavity was 63.1 years; in cancer of the stomach and liver, 61.2 years; in cancer of the peritoneum, intestines and rectum, 59.2 years; in can- cer of the female generative organs, 53.8 years; in cancer of the breast, 58.3 years; in cancer of the skin, 68.0 years; and in cancer of other or- gans and parts of the body not specified, 56.9 years. Cancer is essentially a disease of advanced adult life. Of the mor- tality from all causes in the registration area, 1908-12, at ages 45 and over, the proportion of deaths from cancer was 9.3 per cent., or 7.1 per cent, for males and 11.9 per cent, for females. During the period 1901-11 in the states included in the registration area in 1900 (Table 60, Appendix F, Part 1) the cancer death rate for all ages increased from 65.8 *Estimated on the basis of the actual distribution of the mortaJity by organs and parts in the United States registration area in 1913. 77 THE MORTALITY FROM CANCER per 100,000 of population in 1901 to 83.9 in 1911. The cancer death rate of males increased from 48.7 to 64.2 per 100,000 of population, or 31.8 per cent., and the cancer death rate of females increased from 83.0 to 104.0, or 25.3 per cent. For males the increase in cancer during this period was 21 per cent, at ages 45-54; at ages 55-64 it was 39 per cent. ; at ages 65-74 it was 40 per cent. ; and at ages 75 and over it was 40 per cent. For females the increase in the cancer death rate at ages 45-54 was 11 per cent.; at ages 55-64 it was 27 per cent.; at ages 65-74 it was 32 per cent. ; and at ages 75 and over it was 44 per cent. Cancer and Insurance Medicine As a problem in insurance medicine cancer presents unusual difficulties to both the examining physician and the medical director. The litera- ture of the subject extends over more than half a century, since prac- tically every authority on insurance medicine has given the subject at least incidental consideration. Most of the earlier writers, beginning with Brinton in 1856, emphasize the assumed hereditary character of cancerous affections, but as early as 1857 Ward called attention to the personal aspects of the disease, as made evident m "sallowness or pallor of the face, the general clayey hue of the skin, and peculiar sadness of expression." Also, "the anaemic, chlorotic aspect of females suffering from uterine derangement." Allen, who was one of the first American writers on insurance medicine, in his "Medical Examinations for Life Insurance," published in 1866, referred briefly to the subject, under the general title of tumors, giving a few directions of value in medical exam- inations and advising unconditional rejection even in the case of sus- picion of a liability to non-malignant tumors, as involving danger by their anatomical position or as possibly requiring a severe surgical operation. Observations by Sieveking and Moinet Sieveking in 1874 advanced the view that while authorities differed as to the frequency with which cancer was hereditary, "all are agreed as to the general fact." He quotes Velpeau as being of the opinion that one in three cases of cancer showed a hereditary taint. Sir James Paget's investigations as yielding one in four, Sibley's statistics of the Middlesex Hospital as showing a proportion of one in twelve; but regardless of the wide variation he accepted the view of the "undoubted hereditariness of cancer." Moinet in 1876 in his "Guide to Medical Examination for Life Insur- ance," also referred to the investigations of Paget as indicating a ten- dency of cancerous disease "to pass by inheritance from parent to off- spring and to occur (probably by inheritance of common properties) in many members of the same family and generation." Observations by Greene, Hall and Ramsey These views have continued to prevail among writers on cancer as a problem in medical selection for insurance, and passing over a number of early authors whose conclusions are practically identical, a first reference requires to be made to the standard treatise by Charles Lyman Greene on "Medical Examination for Life Insurance," published in 1905, in which occurs the statement that "The hereditary nature of cancer is 78 CANCER AND LIFE INSURANCE a subject of dispute, but the weight of evidence is strongly in favor of a well-marked hereditary influence." Haviland Hall in 1906 in the third edition of his "Medical Examination for Life Assurance," writes that "Cancer comes next to consumption in regard to frequency of hereditary transmission." Ramsey in 1908 in his "Practical Life Insurance Examinations," accepts the hereditary theory of cancer oc- currence, and Brockbank in 1908 in his work on "Life Insurance and General Practice," concludes that "Females show a greater tendency to inherit whatever is the condition which leads to cancer than males do, and they also die from it at a younger age than their brothers would." London Equitable Experience, 1800-1821 Few of the writers on insurance medicine have given useful advice on methods of diagnosis to disclose either an existing cancerous condition or a well-pronounced tendency to the disease. The over-emphasis placed on the assumed hereditary theory has no doubt done much harm, in that it has prevented a due consideration of the non-hereditary aspects of the disease when considered from a life insurance point of view. It is also quite probable that most of the writers have taken for granted a general disposition on the part of the examining physician to accept and act upon the prevailing theories in medical diagnosis, direct and differential, which, it is needless to say, has made considerable progress during recent years. This conclusion applies not only to cancers in general, but particularly to cancer of the stomach and in the case of women, to cancer of the breast. Cancer, in the experience of life insurance companies, has been the subject of occasional consideration, but not of very extended and thoroughly specialized inquiry. A review of the available statistics, extending over more than a century, tends to confirm the conclusion that during the long intervening period of time the mortality from can- cer has gradually and persistently increased from a comparatively low rate of occurrence to a frequency that may appropriately be considered a menace to mankind. The earliest experience data are those of the London Equitable Society for the period 1800-21, in which out of 1,930 deaths from all causes, only 25, or 1.3 per cent., were from cancer; eliminating deaths under age 40, it appears that out of 1,720 deaths from all causes, 24, or 1.4 per cent., were ascribed to cancer. Scottish Widows' Fund Experience, 1815-1852 The Scottish Widows' Fund published its experience for the period 1815-45, by divisional periods of life, but not by sex, including 642 deaths from all causes, and of this number only 6, or 0.9 per cent., were from cancer, but in addition thereto,5,or 0.8 per cent., were ascribed to tumors. The experience of the same society for 1846-52 was published in the form of a treatise on medical statistics of life assurance, by James Begbie, in the year 1853. This experience includes 690 deaths from all causes, of which only 5, or 0.7 per cent., were from cancer, but 7, or 1.0 per cent, of the mortality, were ascribed to tumors. It is practically certain that in the experience of this company most, if not all, of the deaths from tumors were due to malignant growths, as made clear by the following remarks of the author: 79 THE MORTALITY FROM CANCER Two of the cases of cancer occurred in the female breast; one in the testis of a young man of 26; and the remaining two in the face, the subjects being males of the ages of 56 and 63. Under the name of tumor, seven deaths are recorded. Two of these occurred in elderly gentlemen of 74 and 75 ; and the disease in both appeared to be of malignant growth. Two occurred in men of 41 and 57; the disease affected the abdomen, and was considered of encephaloid character. In another, the fatal disease appeared on the right side subse- quent to amputation for disease of the knee-joint. The sixth death arose from malignant tumor of the foot; and the seventh from that of the jaw. If, therefore, the deaths from cancer and tumors are combined, it appears that there were 12 deaths from malignant disease out of a total mortality of 690, or 1.7 per cent., which compares with a combined mortality from cancers and tumors of 11 deaths during the period 1815-45 out of a total mortality of 642, or also 1.7 per cent. Scottish Amicable Experience, 1826-1860 The Scottish Amicable experience for 1826-60 was published in 1861, giving details of the mortality according to non-hazardous, hazardous and West Indian risk exposure, by ages and divisional periods of life. The non-hazardous risks were the most numerous, including 632 deaths of males, of which 11, or 1.7 per cent., were deaths from cancer, and 63 deaths of females, of which 3, or 5.3 percent., were from malignant disease. In addition thereto, among the males there were 2 deaths from tumors, equivalent to 0.3 per cent. In the hazardous class of risks there were 47 deaths from all causes, with no deaths from cancer, and in the West Indian group of risks there were 31 deaths from all causes, also with no deaths from cancer. Standard Life Company Experience, 1825-1855 The Standard Life Assurance Company experience for 1825-45 in- cludes 193 deaths of males, of which none were ascribed to cancers or tumors, but out of 23 deaths of females, 1, or 4.3 per cent., was attributed to cancer. The experience of the same company for 1845-50 included 293 deaths of males and females and, of this number 3, or 1.0 per cent., were ascribed to malignant disease. The same company also published its experience for 1850-55, including 424 deaths from all causes, of which 5, or 1.2 per cent., were attributed to malignant disease. In the report on the company's experience, published in 1858, the subject of cancer is referred to at some length, it being stated that the term includes cancer, scirrhus, fungus hsematodes and some other malignant affections of less frequent occurrence. The report points out that Diseases of this denomination have not hitherto received from Assurance Companies the attention which they appear to me to deserve. They are well known to be most frequent about middle life, and between that and commencing old age. They occur, therefore, chiefly at a period immediately subsequent to that at which many assurances are effected. Of 717 deaths during the last ten years among those assured in the Standard Assurance Company, no fewer than 426 happened among persons assured for the first time after the age of 40. Death from malignant disease is also frequent — more so than may appear either from the statistical returns of Assurance Companies, or from the mortality tables of the country at large. During the last quinquennium of the Standard Assurance Company, only five deaths are referred to maHgnant diseases, and three in the previous quinquennium — that is, a trifle above one per cent, of the total deaths in ten years. But the majority of deaths referred in the Table to disease of the stomach and disease of the uterus, 24 in number, have also undoubtedly arisen from malignant affections of these organs. Another addition may be confidently made of a fair proportion of 33 deaths 80 CANCER AND LIFE INSURANCE referred to disease of the liver. And I apprehend that a further addition must be made of a smaller, yet no insignificant, proportion of 46 deaths ascribed to disease in the bladder, disease in the kidneys, dropsy, and obstruction of the bowels; since it is no uncommon thing for structural changes of a malignant character to be at the foundation of these disorders. Assuming one-half of the first denomination, a fourth of the second, and a tenth of the third, to have been owing fundamentally to mahgnant degenerations of some internal organ, we will be under the truth, I apprehend, in thus raising the deaths from malignant diseases to eight per cent, of the mortality among persons assured after the age of forty. It will not be easy to arrive at a more precise result than this from the experience of an Assurance Company. Greater accuracy may be effected by and by in the certificates of the cause of death, as medical men become better acquainted with their object, and the importance of accuracy in them. Accordingly, it is not unworthy of note, that the frequency with which malignant disease is mentioned in the certificates of death received by the Standard Assurance Company has increased since this paper was read to the Medico-Chirurgical Society two years ago. For of 192 deaths between 15th November, 1855, and loth November, 1857, six are confidently referred to malignant diseases of the breast, leg, or stomach. But, in point of fact, there is an insuperable obstacle in the way of more definite information; one not to be removed by any amount of zeal or conscien- tiousness on the part of the certifying physicians. The proof of a disease being malignant in its nature can seldom be obtained, if it affect an internal organ, without an inspec- tion of the body after death; and I regret to say that this is a rare help to Assurance statistics, at all events in the experience of the Standard Company. For the same reason it is vain to turn for better information to the mortality registers of the country at large. More precise information may perhaps be expected from the records of a great hospital, where, as in the Royal Infirmary of Edinburgh, pathological examina- tions are numerous, carefully made, and faithfully recorded. But various reasons may be stated against accepting results thus obtained as representing the incidents of an Assurance Company. Dr. William T. Gairdner has had the goodness to search for me the Patho- logical Registers of the Edinburgh Infirmary, which are kept with great accuracy, and the result is, that of 657 inspections there were only 28 [4.26%] in which malignant disease was found in one organ or another; and this number represents merely the relative frequency of malignant alterations of structure, not the frequency of death from that cause. There can be no question that the proportion thus arrived at is materially under what the ex- perience of an Assurance Company would lead to, were it susceptible of an equally rigorous scrutiny. Assuming in the meantime that malignant disease accounts more or less directly for the death of eight per cent, of the subjects of Assurance who die after assuring subse- quently to their fortieth year, it is obviously very desirable to possess some means of avoiding such risks. The resources for that purpose, which are mthin reach at present, are in general not very precise, and perhaps are not often available. But they are the following: — 1. The presence of cutaneous sores or excrescences of a dubious nature — indolent internal tumors, possibly not occasioning inconvenience for a time — suspicious enlargement of the external glands — special symptoms referrible to particular internal organs, such as a great liability to dyspepsia, as being a frequent precursor of scirrhus in the stomach — a progressive general emaciation, without apparent cause, and possibly even without loss of strength or other inconvenience for some months: 2. Proof of a ten- dency to malignant disease among the members of the immediate family of the proposer: and, 3. Proof of a tendency to scrofulous diseases either in the proposer himself, or among his nearest blood relations. It is unnecessary to enlarge upon any of these criterions for the present. I may merely, in regard to the last of them, refer to what was said in my former quinquennial report on the apparent connection between the scrofulous and the cancerous constitutions, and add that further experience confirms me in the belief in the community of these constitutional infirmities. It is a common idea with medical men, when they grant health-certificates for the purpose of Assurance, to suppose that when a man who is a member of a decidedly scrofulous family reaches the age of 45 or 50 in a tolerably sound state of health, the family constitutional failing may cease to be regarded. This is a great error. On watching the history of such cases narrowly, it will often be seen that the constitutional infirmity be- trays itself at last in an unusual liability to organic diseases of internal organs, in an in- ferior power of contending with diseases at large, or in the actual development of structural disease of the majignant type. 81 THE MORTALITY FROM CANCER These observations would seem to sustain the conclusion that the recorded mortality from cancer during the early period of life insurance experience was probably short of representing with absolute complete- ness the total number of deaths from malignant disease, but it is equally clear that the tendency to include non-malignant diseases in the malig- nant group was quite pronounced. Scottish Widows' Fund Experience, 1853-1859 The Scottish Widows' Fund Society's experience for 1853-59 includes 975 deaths from all causes, of which 28 were specifically ascribed to cancer, and 3 additional deaths to tumor. Cancer at this period was usually included in the class of diseases of uncertain seat, with reference to which it is observed by Dr. James Begbie, in a report printed in 1860, that In this class there is a slight increase, — the number of deaths from these causes being 59 on this occasion, and 40 at the former septennial period, that is, from 5% to 6 per cent, of the total mortality. This increase arises mainly from one source, namely. Cancer, under which there are 28 deaths against 5 in our former table. It is gratifying to find that, in consequence of the greater attention to accuracy in the returns. Debility has no place in our present investigation, and that Dropsy only figures as the cause of 4 deaths. The causes which have led to the large addition to the mortality from Cancer, no doubt originate in the same improvement in the certificates of death; but they can be traced also to the circumstance that the advanced age of the Society has brought forward an increasing number of risks to the age at which malignant disease more commonly develops itself. Of the 28 victims of Cancer who have fallen during the present investigation, ten efiFected assurance before 40 years of age; nine between 40 and 50; seven between 50 and 60; one between 60 and 70; and one after 70 years of age. Of these, only one died before 40; four between 40 and 50; five between 50 and 60; fifteen between 60 and 70; two between 70 and 80; and one — she who assured at 71 — fell at the ripe age of 85. The average ex- pectation of these parties was 25.14; iheir average endurance was 15.41 years. These emerged risks embrace nineteen males and nine females, and are distributed over sixteen professions or occupations, two of them only having a double number. In seven females the disease affected the breast; in one, its seat was in the liver; and in another, in the rectum. In one male it manifested itself in the breast; in three, in the abdomen; in three, in the gullet; in three, in the rectum; in two, in the tongue; in two, in the stomach; in two, in the groin; in one, in the kidney; and in one, in the lungs. In one only its seat has not been ascertained. There cannot be a doubt that, under the name of disease of the stomach and bowels, and of the liver, lungs, and other internal organs, many certificates of death have been returned, for which Cancer or other malignant disease could more appropriately have been substituted as the fatal cause. The conclusions of Dr. Begbie are, therefore, quite in conformity to the experience of the Standard, previously referred to at considerable length, but the fact must not be overlooked that these observations and conclusions have reference to a large portion of the first half of the nineteenth century, when the medical diagnosis of the causes of death was naturally less perfectly developed than during more recent years of life insurance experience. London Metropolitan Experience, 1835-1864 The London Metropolitan experience was published for the years 1835-64, by divisional periods of life, but not by sex. The number of deaths from all causes was 671, of which 16, or 2.4 per cent., were ascribed to cancers, and 2 additional deaths, or 0.3 per cent., to tumors. 82 CANCER AND LIFE INSURANCE British Empire Mutual Experience, 1847-1878 The early British Empire Mutual experience is for two periods, 1847-72 and 1873-78. During the first period there were 1,999 deaths from all causes, of which 43, or 2.2 per cent., were ascribed to cancer, and 14 addi- tional deaths, or 0.7 per cent., were from tumors. In the period 1873-78 there were 1,179 deaths from all causes, of which 36, or 3.1 per cent., were attributed to cancer, and 6 deaths, or 0.5 per cent., to tumors. Subsequently the company published its experience for 1879-84, but without distinction of age and sex, including a total of 1,300 deaths from all causes, of which 42, or 3.2 per cent., were from cancer, and 10 deaths, or 0.8 per cent., were from tumors. The same company published its experience with reference to publicans only for the period 1846-76, in- cluding 123 deaths from all causes, of which 2, or 1.6 per cent., were deaths from cancer, and one additional death was from tumor. The Gotha Experience, 1829-1878 The Gotha Life Insurance Company in 1902 published the results of its experience, by causes of death, during the period 1829-78. Out of 19,080 deaths from all causes, 1,322, or 6.6 per cent., were from malignant disease. In proportion to the exposed to risk, the mortality rate was 1.37 per 1,000, which compares with 1.36 for typhoid fever and 3.26 for tuberculosis of the lungs. Omitting ages 50 and under, the cancer death rate was 1.31 at ages 51-55, 2.26 at ages 56-60, 3.91 at ages 61-65, 4.92 at ages 66-70, 5.74 at ages 71-75, 4.95 at ages 76-80 and 5.56 at ages 81-85. The mortality from cancer is not discussed at length, but it is pointed out that the specific nature of the disease was not always indicated, so that no analysis could be made by organs and parts of the body affected. Considered by duration of insurance, but limiting the exposed to risk to ages 36-75 , inclusive, it is shown that the actual cancer mortality to the expected during the first year of insurance was 30.0 per cent. ; during the 2d-5th years, inclusive, it was 76.4 per cent., and during the 6th-10th years, inclusive, it was 91.7 per cent. It would, therefore, appear that the mortality from cancer was reduced by medical selection during the early years of insurance duration, and as far as it is possible to judge, rather more so than in the aggregate mortality experience of the com- pany for durations of less than six years. King and Newsholme's Medico- Actuarial Observations An investigation of unusual interest, with some reference to insurance experience, was made in 1893, by Mr. George King, a Fellow of the Insti- tute of Actuaries, and Dr. Arthur Newsholme, the well-known author of a treatise on vital statistics. The investigation was published under the title "On the Alleged Increase of Cancer," appearing in the Proceedings of the Royal Society for 1893. For additional observations on the inves- tigations of King and Newsholme see Chapter III. The investigation includes a study of the experience of the British Empire Mutual, pre- viously referred to, and of the Scottish Widows' Fund, for the period 1860-87. The conclusions of these two distinguished authorities are summarized in the statement that "The increase in cancer is only appar- ent and not real and is due to improvement in diagnosis and more TEE MORTALITY FROM CANCER careful certification of the causes of death. This is shown by the fact that the whole of the increase has taken place in inaccessible cancer, difficult of diagnosis, while accessible cancer, easily diagnosed, has remained practically stationary." With the highest regard for the weight of opinion expressed by Messrs. King and Newsholme, I feel constrained to hold that this conclusion is not fully and clearly sustained by the evidence submitted by them, nor by subsequent ex- perience as derived either from life insurance data or from general sources of information. The authors of this frequently quoted report did not thoroughly examine the individual facts as regards diagnosis and death certification, which would, in any event, have been advisable, if not absolutely necessary, to substantiate their point of view. Their sugges- tion that trustworthy statistics of cancer should in all cases be based upon an autopsy and a microscopical examination of the diseased parts invalidates all cancer statistics, including the very data upon which they rely to sustain their conclusion that the increase in the cancer death rate is only apparent and not real. Since this conclusion has quite recently been advanced again and brought to public attention in this country, it has seemed of importance to refer to the controversy at some length elsewhere in this work. The argument was thoroughly considered by Dr. J. F. Payne in his Hunterian Society lecture, delivered on October 12, 1898, whose conclusions sustain the point of view that there has been an actual increase in cancer during recent years, measured with approxi- mate accuracy by the available statistical data on the subject. Scottish Widows' Fund Experience, 1874-1894 Not only is the theory of an actual increase in the mortality from can- cer sustained by the mortality statistics of the general population, but corresponding evidence is to be derived from the experience of the Scottish Widows' Fund Society, upon which much reliance was placed by Messrs. King and Newsholme in the paper referred to. The results of an exhaustive investigation of the Society's experience during 1874-94, by its medical officer. Dr. Claud Muirhead, were published in 1902, in which, after calling attention to the increase in the cancer death rate of England and Wales, by divisional periods of life, during the years 1861- 90, the author draws attention to the following facts : (1) It is important to note that here, as elsewhere throughout this Report, deaths of Males only are considered. (2) The term "Cancer" is employed as synonymous with "Malignant Disease," and includes all the various forms of cancer. (3) In many cases, although Cancer was suspected, the certificates of death were very indefinite, and rendered it difficult to assign the disease to its legitimate class. Some of these unsatisfactory certificates were returned to the grantors of them, with a request for further details, which request was usually courteously responded to. In other cases, where the date of the certificate was so remote that it was unlikely that further informa- tion could be obtained, the details available have been most carefully considered; and where the age of the individual at death, the site of the lesion, and the duration of the final illness, have seemed to offer reasonable ground for believing it to be one of malignant disease, it has been so treated, and transferred to this sub-heading. The total number of deaths from Cancer among the male lives assured in the Scottish Widows' Fund during the twenty-one years 1874-94, was 539, equivalent to 5.883 per cent, of the total mortality. The average age at death was 60.385 years. The following is a comparative statement of the total deaths in each of the three Septennia: — 84 CANCER AND LIFE INSURANCE Scottish Widows' Fund Experience, 1874-1894 Number of Septennium Deaths 1874-1880 122 1881-1887 165 1888-1894 252 Percentage of Deaths in Septennium Average Age at Death 4.935 61.980 5.440 59.819 6.889 59.985 Two points of interest are at once apparent from this Table — (1) That, as measured by the total deaths from all causes, there has been a very con- siderable increase in the mortality from Cancer among our members during the 21 years. It is worthy of note that the actual number of deaths during 1888-94 was more than double the number during 1874-80. (2) That there was a very serious decrease in the average age at death from 1874-80 to 1881-87, and a very slight recovery in age from 1881-87 to 1888-94. This is contrary to our experience for deaths from all causes, the average age at death for the total mortality in each Septennium being 57.083, 58.105, and 59.192 years respectively. Before considering the apparent increase of Cancer among our members, let us look at our rate of mortality from that disease as compared with that for England: — Annual Mortality from Cancer in England and the Scottish Widows' Fund among 10,000 (Males) Living at Each Group of Ages England Scottish Widows' Groups of Ages 1881-90 1874-94 Between Ages 20 and 25 57 25 and 35 79 .82 " 35 and 45 2.97 2.56 " 45 and 55 9.98 7.48 " 55 and 65 22.99 23.99 65 and 75 37.42 41.91 Ages 75 and over 39.14 43.09 From this table we see that for the 21 years, 1874-94, from Group 55-65 onwards, our death rate was very considerably higher than that for England for 1881-90. This is a fact to which I shall refer later on. I shall now proceed to consider the question of the apparent increase of Cancer, as a cause of death, among our members as compared with the increase among the community. For the purposes of this comparison I have taken the official figures for the two decennial periods 1871-80 and 1881-90 from the Supplementary Report referred to, because they are readily accessible and near enough in point of time to our own periods to afford compara- tive data: — Comparative Mortality from Cancer in England and the Scottish Widows' Fund among 10,000 (Males) Living at All Ages England Scottish Widows' Fund Life Assurance Society Period Death Rate Ratio Period Death Rate Ratio Period Death Rate Ratio 1871-80.. .... 3.12 100 1874-80 7.86 100 1874-80.... .. 7.86 100 1881-90. . . ... 4.30 138 1881-87 8.19 104 1888-94.... . . 10.42 133 Difference 1.18 38 Difference. . . . .33 4 Difference. . . . 2.56 33 Inspection of this table brings out the following facts : — (1) That the death rate from Cancer among the General Population (Males) of England increased 38 per cent, in 1881-90 as compared with 1871-80. (2) That the death rate among the Members of the Scottish Widows' Fund — (a) Increased 4 per cent, from 1874-80 to 1881-87. (6) Increased 33 per cent, from 1874-80 to 1880-94. That the rate of mortality among our members should only have increased 4 per cent, from 1874-80 to 1881-87 is surprising, and, combined with the fact that our rate of mortality at the older ages is considerably higher than that for the general population, appears to 85 THE MORTALITY FROM CANCER support the theory that the increase in Cancer is only apparent. In the Supplement to the 45th Annual Report of the Registrar-General for England, issued in 1885, Dr. Ogle, commenting on the steady and progressive rise in the mortality from Cancer, remarked: "There can be very little doubt that a considerable part in this apparent increase is simply due to improved diagnosis, and more careful statement of cause on the part of medical men. . . The increase of mortality from Cancer has been much greater among males than among females. . . Now, were the rise not merely apparent but real, being due to general physical deterioration of the people or other similar causes, there would seem no reason why the male sex should have suffered more than the female; whereas the difference is readily intelligible on the hypothesis that the rise has been, at any rate in great measure, only apparent and due to better diagnosis. For the cancerous affections of males are in much larger proportion internal, or inaccessible, than are those of females, and consequently are more diflScult of recognition, so that any improvement in diagnosis would add more to the male than to the female reckoning." This argument is repeated by Dr. Tatham in the Supplement to the 55th Report.* If this argument be sound, it is evident that such a large increase would not be ex- pected among the constituents of a Society like ours — the majority of whom can command the services of skilled medical men — as among the general community, and, as stated above, the small increase in our death rate from the first to the second Septennium seems to support this theory; but the figures relative to 1888-94 greatly diminish the force and cogency of the reasoning. Let me repeat that every death where there was a suspicion of Cancer has been carefully investigated, and if necessary included under Cancer, and under these circumstances I think it is evident that the theory that the large increase between the rate of mortality for 1881-87 and that for 1888-94—27 per cent.— was wholly, or even largely, caused by a sudden increase of diagnostic skill among the class of medical men who usually certify causes of death to the Society, is untenable. I am more inclined to believe that, in addition to the increase due to more exact returns, there has been a very real progressive increase in Cancer as a cause of death, and that the small increase in our death rate for 1881-87, and the large increase for 1888-94, are accounted for by the prob- ability that an increase in a disease like Cancer would show itself, first among the general population, and last among selected lives.f There is another aspect of the case to be considered, and one where our statistics directly controvert the reasoning of those who think that the increase in cancer is only apparent. It has been sought to support this proposition by the statement that it is Cancer of the internal organs which is largely on the increase. These cases being obviously more diffi- cult to recognize than corresponding affections of the external organs, the increase is ascribed to improved skill in diagnosis on the part of the Reporters. Before proceeding to examine our statistics as to the truth or fallacy of this statement, it will be convenient to explain which lesions are regarded as External, and which as In- ternal. The arrangement is somewhat arbitrary, but is based upon the accessibility or non-accessibility of the parts to touch and sight. Hence the accessible lesions are styled External, the deeper and non-accessible lesions. Internal. As an Example of the External, Cancer of the Tongue may be cited, and of the Internal, Cancer of the Stomach. We have in all 539 cases of Cancer to deal with, but for our present purpose 27 of these must be deducted, as in them the site of the disease was not specified, thus leaving 512 cases in which the site of the lesion was detailed. The following Table shows these 512 deaths subdivided into Cancer of the Internal and Cancer of the External Organs for the three Septennia, separately and combined; and the percentages which these numbers bear to the total in each period of time. The differences between the Ratios show the variations per cent, of these percentages, and indicate the increase or decrease per cent, from the first Septennium. •For an extended discussion of the precbe classification of cancer deaths as to whether of the accessible, inaccessible or intermediate organs or parts, see Chapter I and Table 8, Appendix A. fl have quite fully discussed the question of accuracy and completeness in American death registration in an address at the Jacksonville meeting of the American Public Health Association (1914). The results of an original investigation of autopsy records compared with the clinical diagnoses will in course of time be published by the Johns Hopkins Hospital, of Baltimore, Md., including about 5,000 cases, thoroughly and critically con- sidered by members of the medical department of The Prudential Insurance Company of America. This investigation is practically certain to add materially to the existing state of knowledge regarding the accuracy and completeness of death certification in a typical and representative city of America. The investigation is made jointly under the direction of Dr. M. C. Winternitz, resident pathologist of the Johns Hopkins Hospital, Dr. Walter A. Jaquith, Medical Director of The Prudential and myself. 86 CANCER AND LIFE INSURANCE Scottish Widows' Fund Experience, 1874-1894 Mortality from Cancer of the Internal and External Organs Period 1874-80 1881-87 1888-94 1874-94 Deaths fhom Cancer of the Internal Organs Number Percentage Ratio 81 71.05 100.00 107 70.86 99.73 162 65.58 92.30 350 68.36 Deaths from Cancer of the ExTEHNAii Organs Number Percentage Ratio 33 28.95 100.00 44 29.14 100.66 85 34.42 118.89 162 31.64 Total Deaths from Cancer Where Site of Disease Was Specified 114 151 247 512 From this it appears that the deaths from Cancer of the Internal Organs amounted to 71.05 per cent, of the total specified cases in the first Septennium, and to 65.58 per cent. in the third Septenniimi, equal to a decrease of 7.70 per cent, of the percentage value of the first; while the deaths falling into the External class formed in the first Septennium 28.95 per cent, of the specified cases, and 34.42 per cent, in the third Septennium, equal to an increase of 18.89 per cent, over the percentage value of the first. The next Table shows that the increase in the death rate fully supports the results obtained by comparing the percentages of actual deaths. Scottish Widows' Fund Experience, 1874-1894 Mortality from Cancer of Internal and External Organs, Separately and Combined, among 10,000 (Males) Living at All Ages Period 1874-80 1881-87 1888-94 Internal, Organs Death Rate Ratio 5.22 100.00 5.31 101.72 6.70 128.35 External Organs Death Rate 2.12 2.18 3.52 Ratio 100.00 102.83 166.04 Total Death Rate Ratio 7.34 100.00 7.49 102.04 10.22 139.24 The statement made by Dr. Ogle and repeated by Dr. Tatham, that the chief increase in the mortality from Cancer among the community was due to the multiplication of male deaths, may be accepted without question; but our statistics do not support their conten- tion that the additional deaths belonged to the Internal or Inaccessible Group, and in our Society our Reporters can not lay claim to any enlarged knowledge or greater skill by reason of an additional nimiber of cases of Internal Cancer being diagnosed. Going into detail, the two following Tables show the deaths from Cancer among our members during the three Septennia, separately and combined, subdivided among the organs affected; and the percentages these numbers bear to the total deaths from Cancer where the site of the disease was specified, in each period of time. Scottish Widows' Fund Experience, 1874-1894 Mortality from Cancer of the Internal Organs 1874-80 1881-87 1888-94 1874-94 Organ Affected No. Per Cent. No. Per Cent. No. Per Cent. No. Per Cent. Stomach 28 24.56 33 21.85 50 20.24 111 21.68 Liver 23 20.18 28 18.55 42 17.00 93 18.17 Bowel 5 4.39 15 9.93 23 9.31 43 8.40 Abdomen 7 6.14 13 8.60 14 5.67 34 6.64 Bladder 5 4.39 3 1.99 8 3.24 16 3.13 Mediastinum and thorax 1 0.88 8 5.30 4 1.62 13 2.54 (Esophagus 2 1.75 2 1.33 8 3.24 12 2.34 Prostate 3 2.65 2 1.33 3 1.21 8 1.56 Kidneys 2 1.75 1 0.66 4 1.62 7 1.37 Pancreas 3 2.63 .. .. 3 1.21 6 1.17 Lung 2 1.75 1 0.68 2 0.81 5 0.98 Brain . . . . . . 1 0.41 1 0.19 Spinal cord .. 1 0.66 .. .. 1 0.19 Total .- 81 71.05 107 70.86 162 65.58 350 68.36 87 TEE MORTALITY FROM CANCER Scottish Widows' Fund Experience, 1874-1894 Mortality from Cancer of the External Organs 1874-80 1881-87 1888-94 1874-94 Organ Affected No. Per Cent. No. Per Cent. No. Per Cent. No. Per Cent. Rectum ... 12 10.52 7.02 26 2 17.22 1.33 30 13 12.14 5.26 68 23 13 28 Tongue ... 8 4.49 Tissues ... 4 3.51 5 3.31 8 3.24 17 3.32 Throat ... 3 2.63 1 0.66 5 2.02 9 1.76 Larynx ... 1 0.88 1 0.66 6 2.43 8 1.56 Bones 1 0.66 6 2.43 7 1.37 Mouth 1 0.88 2 1.33 2 0.81 5 0.98 Partoid ... 3 2.63 1 0.66 1 0.41 5 0.98 Glands 1 0.66 4 1.62 5 0.98 Penis 1 0.88 2 1.33 1 0.41 4 0.78 Jaw 4 1.62 4 0.78 Testes 2 0.81 2 0.39 Eye 1 0.66 1 0.41 2 0.39 Lip 2 0.81 2 0.39 Skin 1 0.66 1 0.19 Total ... 33 28.95 44 29.14 85 34.42 162 31.64 Let us now consider the question of the age at death of those of our members who died of Cancer. We have already seen that the average age at death was considerably younger in 1881- 87 and 1888-94 than in 1874-80. The following shows, by means of percentages, at what groups of ages the changes occurred: — Scottish Widows' Fund Experience, 1874-1894 The Percentages at Groups of Ages of the Total Number of Deaths from Cancer in Each Septennium Between Between Between Between Between Septennium gg^"^ Ages Ages Ages Ages Ages Ages 75 25 and 35 35 and 45 45 and 55 55 and 65 65 and 75 and Over 1874-80 1.64 8.20 12.30 33.60 36.88 7.38 1881-87 1.21 9.09 19.39 37.58 23.64 9.09 1888-94 2.78 8.73 21.83 31.75 25.79 9.12 Variations in incidence of Mortality for 1874-80 and for 1888-94 +1.14 +0.53 +9.53 -1.85 -11.09 +1.74 The next table is a truer test of the incidence of the Cancer Mortality, for it takes into account not only the actual deaths, but also the number of living who were exposed to the risk of death for one year, and it practically reproduces in another form all the really important features of the preceding table. Scottish Widows' Fund Experience, 1874-1894 Annual Mortality from Cancer among 10,000 (Males) Living at Each Group of Ages and at All Ages Period 1874-80 1881-87 1888-94 Ages under Between Between Between Between Between Ages Ages Ages Ages Ages 25 and 35 35 and 45 45 and 55 65 and 65 65 and 75 0.51 2.19 4.72 20.78 46.98 0.42 2.37 7.34 25.89 33.67 1.49 2.95 9.02 24.53 45.18 Ages 75 and over All Ages 7.86 42.22 8.19 48.33 10.42 34.68 These tables unmistakably show that the age at which Cancer must be looked upon as a serious cause of death among our members is becoming younger. This fact is more strongly brought out by grouping together a larger number of ages at death. From the table showing the percentages at groups of ages we see that practically 90 per cent, of all our deaths from Cancer took place between ages 35 and 75. If, therefore, we group the 88 CANCER AND LIFE INSURANCE deaths between these ages, the results will be probably more satisfactory than if we in- clude the extremities of the table, because we shall then have eliminated what we may call "accidental" cases of death among our very old or very young members. A few cases of death at either end included in a table like the following might have the effect of put- ting our view of the essential facts entirely out of focus. Scottish Widows' Fund Experience Proportionate and Relative Mortality from Cancer, 1874-1894 PERCENTAGE OF DEATHS IN GROUPS OF AGES TO TOTAL CANCE8 DEATHS IN EACH SEPTENNIUM ANNUAL MORTAL ITT AMONG 10,000(MALES) LIVING AT EACH GROUP OF AGES Period 1874-80 1881-87 1888-94 Between Ages 35 and 55 Per Cent. Ratio 20.50 100 28.48 139 30.56 149 Between Ages 55 and 75 Per Cent. Ratio 70.48 100 61.22 87 57.54 82 Between Between Ages 35 and 55 Ages 55 and 75 Death Rate Ratio Death Rate Ratio 3.23 100 29.35 100 4.40 136 28.43 97 5.63 176 30.85 105 Consideration of the first half of this table shows us that the actual number of deaths from Cancer during 1874-94 was steadily and rapidly transferred from Group 55-75 to Group 35-55, while the figures in the second half of the table show that the increase in our rate of mortality was almost entirely confined to members under 55 years of age, the increase in the dearth rate among the members between 55 and 75 years of age, from 1874-80 to 1888-94, being only 5 per cent., while for the other group it was 76 per cent. Medical Observations and Conclusions Regarding Cancer Increase Reviewing the data which have been submitted, the following conclusions seem to be justified — 1. The registered increase in themumber of deaths from Can,cer is tmdoubted. This is proved by our own statistics, and corroborated by all other authorities. 2. After "allowing that this increase is not wholly real, but may be accounted for, to some extent, on the assumption that the true nature of obscure cases of malignant disease has been recognized with ever-increasing certainty in recent years, and that, as a con- sequence, the statement of death has been made with greater precision than had been formerly the case," there remains a large real increase to account for the large and pro- gressive mortality from this disease. 3. The Age Period at which death from Cancer is most frequent is gradually declining according to the Scottish Widows' Fund Returns. 4. The average age at death from Cancer among our members declined by two years from 1874-80 to 1888-94, as contrasted with a rise in the average age at death from all causes of a little over two years. 5. The Office returns mark a decrease in deaths from Internal Cancer of 7.70 per cent., and an increase in deaths from External Cancer of 18.89 per cent, of the percentages in the First Septennium as contrasted with the Third. Highly interesting as are these statistics, they partake more of scientific than of practical value. They do not enlighten us as to how we may diminish our mortality from this ever-increasing cause of death. We learn from them, however, that during the twenty- one years under observation. Cancer as a cause of death among our members aged from 45 to 65 has made rapid and startling progress. If we compare 1874-80 with 1888-94, we find that practically one-third of all our deaths by Cancer occurred between ages 55 and 65 in each Septennium, but that a great change took place in Groups 45-55 and 65-75, the figures for the first group increasing from 12 per cent, to 22 per cent., and in the last de- creasing from 37 per cent, to 26 per cent. Again, the rate of mortality was nearly doubled for Group 45-55, and increased by 18 per cent, for Group 55-65, while remaining practically constant for Group 65-75. These facts may help us when a proposal is made to the Society, in which the proposer states that one, or even two, of his predecessors died from Cancer. For although our Records show that only about 8 per cent, of our Members who died of Cancer during the twenty-one years under observation stated in their Pro- posal Sheets that some near relative had died of Malignant Disease, the high age at which cancer ends fatally would prevent their family history being anything like complete at the time they proposed for assurance; and the general consensus of opinion goes to show that heredity has a certain importance in Cancer, and cannot be wholly disregarded, although it cannot be denied that less weight is attached to it now than in former days. If, then, 89 THE MORTALITY FROM CANCER a proposer whose family history is tainted as indicated, desires a PoUcy on the Endowment Assurance Scale, maturing at age 45 or 50, I consider that this family history of Cancer may be entirely ignored. But if the policy asked for be an Endowment Assurance matur- ing at an older age, or a Whole Life Assurance, it is a question whether such a proposal should be accepted at ordinary rates. The mortality from Cancer rapidly appreciates after age 50, and, after careful consideration, I am of opinion that probably the best way of treating such a proposal would be to accept it on the Endowment Assurance Scale at age 55 or death. The experience for each Septennium is briefly presented in the following summary observations: 1874-80. — To this terrible disease 122 members fell victims — a number equivalent to 4.935 p>er cent, of the septennial mortality. The average age at death was 61.980. Twelve of these members stated in their Proposal Sheets that either father or mother had died of Cancerous affections. 1881-87. — During this Septennimn 165 members died from Cancer, equivalent to 5.440 per cent, of the septennial mortality. The average age at death was 59.819. Ten stated that either father or mother had died of Cancer. 1888-94.— The number of deaths due to this cause was 252, equivalent to 6.889 per cent, of the septennial mortality. The average age at death was practically the same as in the previous Septennium, viz., 59.985 years. Twenty of the deceased admitted a family history of Cancer at date of Assurance. On account of their exceptional value, these observations by a thor- oughly qualified medical officer of one of the foremost life insurance in- stitutions in the world have been given in full, since the original publication is, as a rule, not conveniently available. They require to be taken into account by all who rely primarily for their conclusions regarding the increase in cancer upon more or less inadequate statistical data and who blindly accept the findings of Messrs. King and News- holme, of a date since which the general cancer death rate has continued to increase, not only in England and Wales, but in practically every civilized country of the world. London Prudential Experience, 1867-1870 Some interesting experience data were published in London in 1871 under the title "Mortality Experience of the Prudential Assurance Com- pany, in the Industrial Branch, for the Years 1867-70, with Observations by Henry Harben." This experience included 17,399 deaths of males from all causes and 17,773 deaths of females. The number of male deaths from cancer was 138, or 0.79 per cent., and of female deaths, 352, or 1.98 per cent. The experience includes almost exclusively lives of the working class, which at that period was in a much less satisfactory economic condition than at the present time. Since the mortality from cancer is apparently more common among the well-to-do than among the poor or wage-earning element, these early statistics of the London Prudential are of some practical value in connection with the present inquiry.* Mutual Life Insurance Company Experience, 1843-1873 The Mutual Life Insurance Company of New York, in 1877, published the results of its mortuary experience for the period 1843-73. The *For observations on the comparative cancer mortality of the rich and the poor, see "Natural History of Can- cer," by W. R. Williams. There are numerous references to the subject in this work, under the index title "Wealth in relation to cancer proclivity." The collective evidence seems to favor the view that the well-to-do are more liable to cancer than the poor. The same subject is discussed in the third volume of the treatise by J. Wolff, who refers to the earlier investigations by Tanchou and Walshe and the more recent inquiries by Braithwaite, who maintains that there is a distinct correlation between excessive meat consumption and can- cer frequency; but the data upon which these conclusions are based must be considered inadequate to the purpose. 00 CANCER AND LIFE INSURANCE number of deaths of males from all causes was 5,223, of which 94, or 1.80 per cent., were deaths from cancer. There were 8 deaths from cancer among the 162 females who died during the period referred to, or 4.94 per cent. Considering that the class of risks dealt with was representative of the more prosperous or well-to-do element of the population, subject to more trustworthy methods of medical diagnosis and death certification than the population at large, it is significant that the number of deaths from cancer should have been less than 2 per cent, for insured males. In view of the unusually low mortality, the medical observations by the authors of the report referred to are of some interest and therefore given, in part, as follows : We had previously shown that the mortaUty from Cancer compared with that from all causes was small for the first five years of insurance, and became very much greater after that periofd. Cancer is usually chronic in its course, often taking years before the final fatal result. Hence the medical examination eliminating those already affected with the disease, it will be only after a few years have elapsed that there can be many deaths from Cancer. We find, however, one marked exception to this rule : the mortality in the first year after insurance is remarkably high, being double that of the second year. This may be merely a matter of chance, on account of the small number of figures; but it is most probable that the disease existed at the time of insurance, and that the applicants denied or concealed their symptoms from the scrutiny of the medical examiners. The relatively high mortality from cancer during the first year of insurance is not confirmed by subsequent insurance experience, but it must be taken into consideration that the actual experience of the company was relatively small. Aside from the foregoing observations it is pointed out in the report that the proportionate mortality from cancer was higher among foreigners than among natives and that there had been only three cases in which there was a family history of the disease. The concluding observations on cancer in relation to medical selection are in part: Although, as we have seen, the difference in the mortality from Cancer among the insured and general population is very great, still it is not a disease which we would expect to be much influenced by medical selection. The etiology of Cancer is too obscure to enable us to detect the probabilities of its approach. Age, inheritance, occupation, and perhaps climate and nationality, have some influence on its causation; but, in the words of Sir James Paget, "After all, when we have assigned to these conditions their full weight in producing the cancerous constitution or state of the blood, that which may strike us most of all is the comparatively small influence which any known internal or external conditions possess." Washington Life Insurance Company Experience The Washington Life Insurance Company published a volume of actuarial and medical statistics in 1889, including an analysis of 2,000 consecutive deaths, of which 68, or 3.4 per cent., had been deaths from cancer. There were also 7 additional deaths from tumors, equivalent to 0.35 per cent, of the mortality from all causes. The report includes many interesting observations on the relation of family history to the disease and the value of medical selection, but the number of deaths considered is unfortunately too small to warrant the acceptance of these conclusions as entirely trustworthy at the present time. It may be quoted, however, from the report, that Although cancer is usually classed among hereditary diseases, there is a wide difference of opinion among authorities as to the exact part played by the hereditary taint in the causation of the disease. Velpeau believed that one in three cases of cancer showed an 91 THE MORTALITY FROM CANCER inherited predisposition; Sir James Paget's investigation yielded one in four; Mr. Sibley concluded from the statistics of the Middlesex Hospital that the proportion was less than one in twelve; the late Willard Parker found a record of cancer in the family of only 56 out of 397 cases of cancer of the breast operated on by him. He expressed it as his well con- sidered opinion that cancer is not a hereditary disease. In the experience of the Washington Life Insurance Company, out of 2.000 deaths from all causes, 56 were deaths of persons with cancer in the family history ; but out of 68 deaths from cancer in the company's experience, only one death was of a person with a history of cancer in the family. It was therefore shown by this experience that the data ' 'support the opinion that has been gaining ground of late among medical men, namely, that the hereditary element is not such an important factor in the production of cancer as was formerly believed." It may be stated in this connection that the average age at entry of the 56 cases with a family history of cancer was 43 years, and the average age at death, 52.62 years, giving an average policy duration of 9.62 years, in compari- son with an average policy duration for the 2,000 deaths from all causes of 8.54 years. This experience, therefore, limited as it was, seemed to warrant the conclusion that "Regarded from the standpoint of life in- surance, a death from cancer in the family record of an applicant does not necessarily prejudice the risk in any respect." Greshatn Company Experience An earlier experience is that of The Gresham Life Assurance Society, published in 1868, including 1,000 deaths from all causes, of which 21, or 2.1 per cent., were deaths from cancer. In addition, however, there were 4 deaths from tumors, equivalent to 0,4 per cent. Clergy Mutual Experience, 1829-1887 A more conclusive experience is that of the Clergy Mutual Assurance Society for the period 1829-87, published in 1891, including 2,119 deaths from all causes, of which 102, or 4.8 per cent., were deaths from cancer. In addition, the society recorded 71 deaths in its experience with sub- standard lives, but of this number only 2, or 2.8 per cent., were deaths from cancer. Mutual Life Experience, 1843-1898 The combined experience of The Mutual Life Insurance Company of New York for the period 1843-98, was published in 1900,* including 44,985 deaths of males, of which 1,882, or 4.18 per cent., were deaths from cancer. In the same experience there were 1,540 deaths of females, of which 127, or 8.25 per cent., were deaths from cancer. In addition thereto there were in the male experience 120 deaths from tumors, or 0.27 per cent, of the deaths from all causes; and in the female experience there were 8 deaths from tumors, equivalent to 0.52 per cent. The can- cer mortality, by divisional periods of life, is given in full in the table following : *Report Exhibiting the Experience of The Mutual Lite Insurance Company of New York for fifteen years ending February 1, 1858, New York, November, 1858. Report on the Mortality Records of The Mutual Life Insurance Company of New York, 1843-1914, New York, 1900. (See Tables 32-33, Appendix D.) CANCER AND LIFE INSURANCE Cancer Mortality Experience of The Mutual Life Insurance Company of New York, 1843-1898 MALES FEMALES Ages at Death All Causes Cancer Per Cent. All Causes Cancer Per Cent. Under 20. 38 2 20-24.. 569 3 0.53 30 25-29 . 1,775 10 0.56 78 30-34 . . 2,900 34 1.17 136 1 0.73 35-39 . 4,034 81 2.01 141 6 4.26 40-44 . 4,307 128 2.97 175 18 10.29 45-49 . 4,621 180 3.90 156 19 12.18 50-54 . 4,944 253 5.12 159 25 15.72 55-59 . 5,283 331 6.27 185 21 11.35 60-64. 5,016 305 6.08 160 17 10.63 65-69 . 4,593 273 5.94 122 8 6.56 70-74. 3,406 170 4.99 71 9 12.68 75-79 . 2,212 89 4.02 92 1 1.08 80-84 . 956 23 2.41 25 2 8.00 85 and over 309 2 0.65 4.18 7 127 •• All ages 44,985* 1,882 l,540t 8.25 •Including 22 age not stated, flncluding 1 age not stated. According to this experience the proportionate mortality was highest for males at ages 55-59, when it was 6.27; and for females at ages 50-54, when it was 15.72 per cent. The proportionate mortality from cancer during four periods of time is shown below. Cancer Mortality Experience of The Mutual Life Insurance Company of New York, 1843-1898 MALES All Ages Ages Under 45 Ages 45 and Over Deaths from C incer Deaths from C ancer Deaths from C ancer All Causes No. Per Cent. All Causes No. Per Cent. All Causes No, Per Cent. 1843-73. . . 5,223* 94 1.80 2,674 25 0.93 2,527 69 2.72 1874-85. .. 10,839 449 4.14 3,028 71 2.34 7,811 378 4.84 1886-93. .. 14,568 631 4.33 3,658 65 1.78 10,910 566 5.19 1894-98. .. 14,355 708 4.93 4.18 4,263 95 256 2.23 1.88 10,092 613 6.07 1843-98. . . 44,985* 1,882 13,623 31,340 1,626 5.19 FEMALES 1843-73. 162t 8 4.94 76 5 6.58 85 3 3.53 1874-85. ai 24 9.72 74 4 5.41 173 20 11.56 1886-93. 456 45 9.87 147 10 6.80 309 35 11.33 1894-98. 675 50 127 7.41 8.25 265 562 6 25 2.26 4.45 410 977 44 102 10.73 1843-98 . . . l,540t 10.44 'Including 22 age not stated, flncluding 1 age not stated. Northwestern Mutual Experience, 1857-1909 Among more recent data are the statistics of the Northwestern Mutual Life Insurance Company for the periods 1857-85 and 1886-1909. The proportionate mortality from cancer during the first period was 93 TEE MORTALITY FROM CANCER 3.4 per cent., against 5.8 per cent, during the last. Naturally, in the case of this as in the experience of some of the other companies referred to, the increasing average age of the insured and a possibly larger pro- portion of persons insured at ages 40 and over would tend, in part at least, to bring about an increased proportionate mortality from cancer, but there are reasons for believing that, if the required correction were made, that the more recent experience would exhibit an actual in- crease in the cancer death rate over earlier years. German Germania Experience, 1857-1894 A large amount of additional statistical information on the subject of cancer is available for American and foreign insurance companies, but the data can be only very briefly referred to. The experience of the Germania, of Stettin, published in 1897, sustains the Gotha experience as regards the value of medical selection in reducing the mortality from cancer during the earlier years of insurance. Considering the two periods of duration of five years or less and six years or more, it appears that the actual mortality of males per 1,000 at ages 31-40 was 0.21 and 0.32, respectively; at ages 41-50 it was 0.67 and 1.14; atages51-60, it was 1.97 and 2.87; and at ages 61 and over, 4.63 and 6.64. The results for females are about the same. The cancer death rate for males was 1 .33 per 1,000, and for females, 1.90. The experience covers the period 1857-94. It may be stated in this connection that for women only the death rate from cancer during the period 1857-82 was 1.38 per 1,000, whereas for the entire period, 1857-94, it was 1.90. There had, therefore, been a not inconsiderable increase in the cancer mortality during the later years, but to be entirely conclusive, the experience should have been extended to insurance durations and divisional periods of life. Austro-Hungarian Experience In the experience of the Austrian Phoenix, the proportionate mor- tality from cancer has increased from 8.5 per cent, during the five years ending with 1906 to 10.4 per cent, during the five years ending with 1912. In the experience of the Riunione Adriatica di Sicurta, of Trieste, the pro- portionate mortality from cancer has decreased from 9.3 per cent, during the seven years ending with 1905 to 8.0 per cent, during the seven years ending with 1912. In the experience of the Alte Leipziger,* which is one of the largest German life insurance companies, the percentage of deaths from cancer has increased from 11.8 during the ten years ending with 1902 to 12.6 during the ten years ending with 1912. In the experience of a large Hungarian company, the Fonciere, however, the proportionate mortality from cancer has declined from 8.6 per cent, during the five years ending with 1905 to 8.0 per cent, during the five years ending with 1911. In the experience of the Assicurazioni Generali, the largest Austrian company, the proportionate mortality from cancer was 9.2 per cent, during 1899-1905, against 9.5 per cent, during 1906-12. The experience of many other foreign companies could be quoted to sustain the conclusion that in most cases the proportionate mortality from cancer has increased during recent years and that, in any event, the *Leipziger Lebensversicheruiigs-Gesellschaft, Leipzig, Germany. 94 CANCER AND LIFE INSURANCE mortality from malignant disease is of much greater importance to life insurance companies than has generally been assumed to be the case. In this connection it is necessary to take into account the probability that medical selection during the last twenty or thirty years has become more effective, on account of the use of more exact and con- clusive methods of medical examination for insurance. Better selec- tion would, of course, tend to reduce the mortality from diseases more accurately diagnosed, particularly during the early years of policy duration. It is true that the rejection rate for cancer is comparatively small, but the implication is that the more general regard to abnormal or subnormal bodily conditions would tend to eliminate applicants pre- disposed to malignant disease. American Insurance Experience, 1869-1900 American investigations tend to confirm this point of view. In 1903 the combined experience of thirty -four American life insurance compa- nies was published by the Actuarial Society of America. It was brought out with reference to persons who had a family history of cancer that the subsequent experience had been very good with young entrants, almost equally good with mature entrants, fairly good with elderly entrants, but not good with old entrants, although the actual number of the latter was hardly sufficient for a final adverse conclusion. On account of their importance the facts are given in detail in the table below, showing first, the actual number of deaths from cancer, second, the number of deaths expected by the standard table adopted and third, the ratio of actual deaths from cancer to every 100 expected. Mortality Experience of Applicants with a Family History of Cancer Thirty-four American Companies, 1869-1900 Age at Entry Actual Deaths 15-28 251 29-42 1,089 43-56 1,138 57-70 352 15-70 2,830 3,154.2 89.7 It is regrettable that the causes of death were not given in this experience, so as to show what proportion of the mortality of persons with cancer in the family history was actually from cancer, or, if not, from w^hat other causes. Medico-Actuarial Investigation, Males* The most recent collective investigation is for the period 1885-1908. The number of deaths of males at ages 15-29 was 4,566, of which 95 were from cancer and other malignant tumors, or 2.1 per cent. The cancer mortality rate at this period of life was 1.0 per 10,000 exposed to risk. At ages 30-44 the number of deaths from all causes was 7,886, of which 377, or 4.8 per cent., were from cancer, equivalent to a rate of 3.2 per 10,000 exposed to risk. At ages 45 and over there were 5,340 *Medico-Actuarial Mortality Investigation, New York, 1913, Vol. ii, p. 26, et seq. 95 Ratio of Actual Ixpected Deaths to Expected Deaths 333.7 75.2 1,313.6 82.9 1,186.3 95.9 320.6 109.8 TEE MORTALITY FROM CANCER deaths from all causes, of which 411 were from cancer, or 7.7 per cent., equivalent to 14.4 per 10,000 exposed to risk. The proportionate mortal- ity and the death rate from cancer and other malignant tumors, of males, by divisional periods of life and duration of insurance, are given in the table following: Experience of American Insurance Companies, 1885-1908 (Medico- Actuarial Investigation) Mortality from Cancer and Other Malignant Tumors ^ STANDARD LIVES, MALES NtJMBER OF Policies Terminated by Death Percentage of Total Deaths Ratio per 100,000 Exposed to Risk Policy Years Ages at Entry 15-29 30-44 45-over Ages at Entry 15-29 30-44 45-over Ages at Entry 15-29 30-44 45-over 1 4 7 15 4 25 42 18 72 111 .6 1.0 3.5 .7 3.6 9.4 1.4 3.9 8.9 .2 .4 3.2 2 .3 1.9 12.0 3-5 .7 2.3 13.6 6-10 30 105 129 2.5 4.7 7.8 1.2 3.3 16.4 11-24 39 168 114 4.1 7.0 7.3 2.3 7.6 26.3 Total 95 377 411 2.1 4.8 7.7 1.0 3.2 14.4 This table confirms the experience of the Gotha and of the German Germania, as well as of other companies, as regards the value of medical selection during the early years of insurance, but the value of selection is distinctly less in the case of applicants ages 45 and over. Medico-Actuarial Investigation, Females The same experience has been made up regarding women policyholders. At ages 15-29 the number of deaths from all causes among insured women was 3,696, of which 98, or 2.7 per cent., were deaths from can- cer, or 1.4 per 10,000 exposed to risk. At ages 30-44 there were 5,661 deaths from all causes, of which 668, or 11.8 per cent., were deaths from cancer, equivalent to a rate of 7,3 per 10,000 exposed to risk. At ages 45 and over there were 4,917 deaths from all causes, of which 654, or 13.3 per cent., were deaths from cancer, or 24.3 per 10,000 exposed to risk. The mortality from cancer among women, by divisional periods of life and duration of insurance, is shown in the table below: Experience of American Insurance Companies, 1885-1908 (Medico- Actuarial Investigation) Mortality from Cancer and Other Malignant Tumors STANDARD LIVES, FEMALES Number of Policies Terminated by Death Percentage of Deaths Total Ratio per 10,000 Exposed to Risk Policy Years Ages at Entry 15-29 30-44 45-over Ages at Entry 15-29 30-44 45-over Ages at Entry 15-29 30-44 45-over 1 7 50 55 5 52 64 24 199 196 1.1 .9 1.9 6.4 6.9 11.0 13.6 15.8 15.2 .5 3.0 12.1 2 .5 4.0 18.1 3-5 1.0 6.6 23.5 6-10 26 240 212 3.0 15.6 13.1 1.6 10.3 28.8 11-24 36 127 127 11.5 16.3 10.5 7.2 15.4 40.7 Total 98 668 654 2.7 11.8 13.3 1.4 7.3 24.3 96 CANCER AND LIFE INSURANCE This table also confirms the previously expressed conclusion as re- gards the value of medical selection in reducing the mortality from cancer during the early years of insurance, but, as in the case of males, more distinctly with regard to younger applicants, and only to a limited extent for applicants ages 45 and over. The American insurance ex- perience with both men and women therefore emphasizes the consider- able importance of cancer as a cause of death at ages 30 and over. Family History of Cancer The influence of a family record of cancer, including two or more cases, was investigated by the Medico-Actuarial Committee, but with negative results. The number of expected deaths in the group of applicants having a family record of two or more cases of cancer in the family history was 87.3, but the actual number of deaths experienced was only 69, or 79 per cent, of the expected. Of the 69 deaths only 4 were from cancer. The evidence is, therefore, quite conclusive that the earlier apprehensions regarding a family history of cancer were not justi- fied by the facts of subsequent experience. In contrast, it may be stated that the ratio of actual to expected deaths in cases in which there was a family record of two or more cases of heart disease was 113 per cent.* Effect of Build The Medico-Actuarial Investigation considered also the relation of build at entry to causes of death, with distinction of three divisional periods of life. Dividing the male applicants into three classes; that is, first, overweights, or those whose weight at entry was 50 pounds or more above normal weight, second, those who were of normal weight, and third, underweights, or those who weighed 25 pounds or more below normal weight, the experience with reference to cancer was as follows : the cancer death rate per 10,000 exposed to risk at ages 15-29 was 0.9 for overweights and 0.8 for underweights, at ages 30-44 it was 3.7 for over- weights and 2.4 for underweights, and at ages 45 and over 15.6 for over- weights and 12.0 for underweights. The experience, therefore, supports the view occasionally expressed by writers on the subject of cancer occurrence that the disease is more common among persons of over- weight than among underweights, and by inference, among the well-to-do and overnourished than among the less prosperous element. The medico-actuarial evidence is of exceptional value, in that it con- firms this conclusion for three periods of life on the basis of what may safely be considered to have been a sufficient numerical exposure, f Effect of Conjugal Condition Considering the importance of this conclusion it is a matter of regret that a corresponding investigation into the mortality of overweights and underweights, by causes of death, should not have been made with *Medico-ActuariaI Mortality Investigation, New York, 1913, Vol. iv. Part i, p. 24. fin the third volume of the treatise on cancer by J. Wolff (p. 37) there is a brief discussion of the probable correlation of height to cancer frequency, the view being advanced that cancer is more common among tall persons than among those of short stature. This phase of the cancer problem has not been sufficiently inquired into, which holds true also of the anthropometric aspects of the cancer problem in general. It, however, re- quires to be kept in mind that there is an important correlation of height to weight and that persons of short stature are as a rule more likely to be overweight than persons above the normal average height. 97 THE MORTALITY FROM CANCER regard to women, but some exceedingly interesting data are furnished by the investigation of deaths according to conjugal condition, briefly set forth in the following table: Experience of American Insurance Companies 1885-1908 (Medico-Actuarial Investigation) Mortality from Cancer and Other Malignant Tumors, according to Conjugal Condition (Rate per 10,000 Exposed to Risk) Ages at Entry 15-29 30-44 45-over Spinsters 0.9 5.2 15.4 Married (beneficiary, husband) 1.5 7.1 20.9 Married (beneficiary other than husband) . 2.9 8.0 ' 26.4 Widowed and divorced 1.7 10^3 25.9 According to this table the mortality from cancer and other malig- nant tumors was distinctly higher at all periods of life among married and widowed women than among spinsters. The married women, for insurance purposes, have been divided into two classes: the first being those who had made their husband the beneficiary in the event of their death and the second being those whose beneficiary was other than their husband. The latter class throughout show a distinctly higher mortality from cancer and other malignant disease. The evidence as regards a lesser liability of spinsters to cancer (all forms) would seem to be conclusive, since the comparative rates represent an apparently sufficient exposure for each of the three divisional periods of life. These results of the medico-actuarial investigation are in conformity to a special analysis of the data for the District of Columbia, which, however, have not been completely standardized for variations in age distribu- tion. For males the cancer death rate for the married was 108.8 per 100,000 of population, ages 15 and over, against 56.6 for the single, and for females the rates were 122.7 for the married and 59.9 for the single. With special reference to cancer of the generative organs, the rates were 41.4 for the married and 11.0 for the single, and for cancer of the breast the rates were 22.0 for the married and 17.8 for the single. When standardized for age these differences would, of course, be more pro- nounced. These rates refer to the white population only. Cancer of the Breast and Generative Organs among Single and Married Women* Some exceptionally valuable observations on the relative frequency of cancer of the breast and of the generative organs among the single and the married have recently been published in the 76th Annual Report of the Registrar-General of Births, Deaths and Marriages in England and Wales (London, 1915). This investigation is the first of its kind, but the conclusions are extremely important. Deaths from cancer of the ovaries, the uterus and the breast are separately considered, according to conj\igal condition, with a due regard to the number of single and married women living at specific periods of life. The usual error arising out of an unequal age distribution is therefore avoided. As observed in *0n account of the preceding discussion with reference to insurance, this section is here included, although derived entirely from the 78th Annual Report of the Registrar-General for England and Wales, London, 1916. 98 CANCER AND LIFE INSURANCE the report, the effect of marital condition upon the mortality from cancer of the generative organs and the breast "is seen to be very considerable." During the three years 1911-13 (which were combined to secure a suffi- cient basis of facts for the purpose and to eUminate chance fluctuations), "the mortality of single women from cancer of the ovary has been twice as great as that of the married, due allowance being made for the different age-distributions of these two sections of the population. The mortality of the unmarried from cancer of the breast similarly exceeded that of the married by 45 per cent." But, in contrast, "from cancer of the uterus the married suffered from a mortaUty 73 per cent, greater than the single." The term married for the present purpose includes the widowed and divorced. It is pointed out that these results are at variance with the usual con- clusions deduced from the available material by surgical authorities, on account of the fact that proper correction is not made for the considerable variations in the age distribution of the single and married, and the equally important variations in the age incidence of the three forms of cancer considered, that is, of the ovary, the uterus and the breast. Extreme care was used in standardizing the rates for the married and single by divisional periods of Hfe, but the methods employed are too technical to require consideration in a work of this kind. They are fully explained in the report, which is conveniently available for general use. The term cancer as employed for the present purpose includes sarcoma, but in the statistical tables the facts are given separately. The general results of this important investigation are briefly summarized as follows : During the period of active sexual life there is practical equality of mortality from breast cancer among the single and the married, but after age 45 the excess among the single becomes very pronounced. The great excess of mortahty from cancer of the uterus among the married is in accordance with the generally accepted views upon this subject. It is regrettable that it should not have been feasible to distinguish cancer of the body of the uterus from cancer of the cervix. In course of time it is to be hoped that all death certificates will be amplified and made to contain these as well as some other necessary additional facts. It is generally held that cancer of the body of the uterus is not more common in mothers than in other women, or more frequent in women who have not given birth. Cancer of the cervix is thought to result from past injury in labor, but few of the certificates give the necessary information, so that for the time being no conclusive answer can be made to this important question. It is shown by the report that "in the case of uterine cancer the difference in mortality"between the married and the single is much greater before than after 50, and that the difference practically disappears after 75. In other words, the difference is most pronounced in the case of uterine cancer and least so in cancer of the breast, but "in each case it is the mortality of the single which increases relatively to that of the married with the advance of age." The importance of treating sarcoma separately is emphasized in the case of cancer of the ovary, where sarcoma is relatively more frequent than in the uterus or breast. In this case, it is pointed out that "the excess of mortahty amongst the single is very great at all ages after 35, 90 TEE MORTALITY FROM CANCER at which the number of deaths is sufficient to attach significance to the figures. The effect of marital condition upon [cancer] mortahty would seem to be at its maximum in the case of the ovary, but has not perhaps attracted so much attention as in the case of the uterus or breast — presumably on account of the lesser frequency of the condition." The rate of increase in mortahty from cancer of the various organs considered is shown to differ quite considerably. After pointing out that "in both sexes the most rapid rates of increase are furnished by cancer of the alimentary tract, especially the intestine and stomach," it is observed that "disease of the female breast also claims a rapidly increasing number of ^actims, while mortality from uterine cancer is diminishing." This curious but very interesting result is in part at- tributed to the diminishing birth rate, and it is said in this connection that "It would appear that child-bearing increases the risk of uterine and diminishes that of mammary cancer, and it is therefore only to be expected that the present decrease in fertility should be accompanied by an increase in mammary but not in uterine cancer." Age and Conjugal Condition in Cancer of the Generative Organs The details of the recent Enghsh experience are given in Tables 15a to 15c of Appendix G. The data have been rearranged in a convenient form for the purpose of facihtating the comparison of the unmarried and the married. The excess in the cancer death rate of either group is indicated and the variations in the rate are shown in the manner of the rate for ages 25-29 being taken as 100. Cancer of the ovary, for illustra- tion, is sho\\Ti to be excessive among the unmarried at all ages excepting 80-84, when the actual numbers, however, are too small for a safe generahzation. The maximum excess in the rate for the unmarried occurs at ages 55-59. Assuming the rate at ages 25-29 as 100, the rate at ages 55-59 is equivalent to 2,422, diminishing gradually towards the end of life, with the exception of ages 75-79, which must be considered ac- cidental. The corresponding rate for the married reaches its greatest rela- tive significance at ages 65-69, declining subsequentlj^ to the end of life. In marked contrast are the results for cancer of the breast. Here it is shown that the rate is excessive for the unmarried, with the exception of ages under 35, when, however, the actual rates are of "relatively small importance. Assuming the rate at ages 25-29 as 100, there is a progres- sive increase in the rate to the end of life; the same is true for the married, but the rise in the rate is slower and of less actual significance. The most marked contrast, however, occurs in the case of cancer of the uterus. There is an excess in the death rate for the married of all ages excepting 80-84, which is probably accidental. Assuming the rate at ages 25-29 as 100, there is a rapid rise towards 50-54, after which the rate remains practically stationary to about the age 75, when there is a further rise and a subsequent decline for the unmarried, but the changes are possibly due, in part at least, to the smallness of the numbers con- sidered at the extreme end of hfe. It would seem. safe to conclude that the relative mortality from cancer of the uterus remains much the same during the period follomng the cessation of active sexual life except at the extreme ages. 100 CANCER AND LIFE INSURANCE These results are exceptionally interesting and of much practical usefulness. They indicate with unusual clearness the value of specialized statistical research into the more involved aspects of the cancer problem. It is to be anticipated that corresponding statistics will, in course of time, be published for at least the registration states of the United States, by the Division of Vital Statistics of the Census Office. Mortality Experience of The Prudential Insurance Company of America Some interesting facts regarding cancer as disclosed by the experience of a large and representative life insurance company were first exhibited by The Prudential in connection with an exhibit made at The Louisiana Purchase Exposition, in 1904. The information has been brought down to date, and the results seem to prove that the proportionate mor- tality from cancer is distinctly less among Industrial risks, repre- sentative of the wage-earning element, and regardless of a more rigid medical examination, distinctly higher among Ordinary risks, repre- sentative of the more prosperous and well-to-do. Considering only the age period 40-59, it appears that for males the proportionate mortality from cancer in the Company's Ordinary experience was 6.9 per cent., against 5.4 per cent, in the Industrial experience. For females the corresponding proportions were 18.7 per cent, in the Ordinary experience and 14.9 per cent, in the Industrial. Throughout, the proportionate mortality from cancer was higher among insured women than among insured men. Selecting, for illustration, the age period 50-54, it appears that in the Industrial experience of The Pru- dential the proportion of deaths from cancer at this period of life was 6.3 per cent, for males, against 16.6 per cent, for females. In the Ordinary experience the corresponding proportions were 8.4 per cent, for males and 19.0 per cent, for females. It is quite probable that the value of medical selection, with particular reference to cancer, is less in the case of insured women than in the case of insured men; but in view of the facts disclosed by the medico-actuarial investigation that there is a distinct value in the medical selection with reference to cancer as shown by the reduced mortality from this disease during the early years of policy duration, it would seem safe to conclude that the proportionate mortality from cancer is higher among the prosperous and well-to-do than among the wage-earning element, including the less prosperous and the poor. The proportionate mortality from cancer in the Industrial and Or- dinary experience of The Prudential is briefly suminarized below: Prudential Ordinary Mortality Experience Mortality from Cancer, by Age and Sex, 1886-1913 Deaths Ages from All Causes Under 45 19,514 45 and over 13,905 Total 33,419 MALES Deaths from Cancer 479 1,184 1,663 Per Cent. 2.5 8.5 5.0 Deaths from All Causes 4,912 2,607 FEMALES Deaths from ' Cancer 7,519 300 464 764 Per Cent. 6.1 17.8 10.2 101 TEE MORTALITY FROM CANCER Prudential Industrial Mortality Experience, White Mortality from Cancer, by Age and Sex, 1909-1913 Ages Under 15. 15-44.... 45 and over . Deaths from All Causes 35,822 64,296 MALES Deaths from Cancer 123 846 95,015 6,243 Total 195,133 7,212 Per Cent. 0.3 1.3 6.6 3.7 FEMALES Deaths Deaths from from All Causes Cancer 30,840 85 60,770 2,917 102,750 11,993 194,360 14,995 Per Cent. 0.3 4.8 11.7 7.7 The table following is a brief summary of the Industrial experience of The Prudential for the years 1909-12, showing the proportionate mortality from cancer and sarcoma by divisional periods of life, according to sex. Prudential Industrial Mortality Experience, White Mortality from Sarcoma and Other Forms of Cancer, by Age and Sex 1909-1912 MALES FEMALES Ages Under 15 Sarc No. of Deaths 44 OMA Per Cent. 15.0 35.0 50.0 Other Forms OF Cancer No. of Per Deaths Cent. 39 0.8 533 10.3 4,589 88.9 Sarc No. of Deaths 26 103 194 323 OMA Per Cent. 8.0 31.9 60.1 Other Forms OP Cancer No. of Per Deaths Cent. 39 0.4 15-44 45 and over 103 147 294 2,114 19.0 8,985 80.6 Total 100.0 5,161 100.0 100.0 11,138 100.0 In amplification of the preceding dicussion two additional tables are included exhibiting the proportionate mortality from sarcoma and other forms of cancer for males and females in The Prudential experience, 1909-12. No corresponding information regarding the age incidence of sarcoma and its bearing upon the general mortality by divisional periods of life is available. It is conclusively shown that sarcoma is of much greater importance during early life than other forms of cancer, but the proportion to the mortality from all causes remains about the same, above age 15, and for both sexes, in marked contrast to the rapid increase in the proportion of deaths from other forms of cancer among males and females, but naturally very much more so among the latter than among the former at ages 45 and over. Of course, it is regrettable that these returns could not have been given with reference to the exposed to risk; but they suflSciently emphasize the practical importance of statistical research in this direction with reference to the mortality from cancer among the general population. Prudential Industrial Mortality Experience, White Proportionate Mortality of Sarcoma and Cancer to All Causes, by Age, Males 1909-1912 Ages Deaths from All Causes Under 15 28,024 15-44 50,032 46 and over 73,490 Total 151,546 Sarcoma No. of Deaths Per Cent. 44 0.16 103 0.21 147 0.20 294 0.19 Other Forms OP Cancer No. of Per Deaths Cent. 39 533 4,589 0.14 1.07 6.24 5,161 3.41 102 CANCER AND LIFE INSURANCE Prudential Industrial Mortality Experience, White Proportionate Mortality of Sarcoma and Cancer to All Causes, by Age, Females 1909-1912 Ages Deaths from All Causes Under 15 24,195 15-44 47,324 45 and over 79,622 Total 151,141 Sabcoma No. of Deaths Per Cent. 26 0.11 103 0.22 194 0.24 323 0.21 Other Forms OP Cancer No. of Deaths 39 2,114 8,985 Per Cent. 0.16 0.45 11.28 11,138 7.37 All the necessary details of this experience, by organs and parts, with data regarding age and sex, are given in Tables 4 to 7, Appendix D. Cancer as a Life Insurance Problem The business of life insurance within the last half-century has attained to enormous proportions. The number of policies in force with legal-reserve life insurance companies of the United States on December 31, 1914, was 40,204,119, of which 31,159,038 were on the Industrial plan. The number of new policies issued during 1914 was 8,091,175, of which 1,398,942 were Ordinary and 6,692,233 were Indus- trial contracts. All of the Ordinary policies and a considerable pro- portion of the Industrial policies are issued upon a medical examination, which has primarily for its object the elimination of risks likely to terminate by death during the early years of policy duration. Medical selection is successful in proportion to the attained reduction of mortality during the early years of policy duration, and this is especially true with regard to chronic diseases. The value of medical selection, however, is both general and special, and the benefit of such selection, with regard to cancer, has been clearly established by the several investiga- tions to which reference has been made at some length. Cancer, by its nature, is representative of a not inconsiderable group of diseases which are extremely difficult of early diagnosis and particularly so for life insurance purposes. It is for this reason that life insurance companies are directly interested in the nation-wide effort to control a disease, which has not inappropriately been described as a scourge, in educational efforts along lines of prevention which have the approval of the foremost authorities in medical and surgical science.* *For additional observations on cancer as a life insurance problem, see my address on "The Educational Value of Cancer Statistics to Insurance Companies, the Public and the Medical Profession," Transactions of the Clinical Congress of Surgeons of North America, 1913. See also observations on cancer in the "Text Book of Legal Medicine," by Peterson and Haines, Philadelphia, 1903, Vol. i, pp. 454-455. 103 CHAPTER VI THE GEOGRAPHICAL INCIDENCE OF CANCER THROUGHOUT THE WORLD Problems of Geographical Pathology — Recent International Statistics — Cancer Frequency throughout the World — Distribution of Cancer in the United States — Local Varia- tions in Cancer Occurrence — Mortality from Biliary Calculi and Tumors of the Uterus and Ovaries — ^Increase in Cancer, by Organs and Parts, and by Age and Sex — Mortality by Season — Statistics of the New York State Pathological Institute — Previous Duration of Malignant Disease — Family History and Heredity — Primary Seat of Growth, Probable Causes, and Personal History — Geographical Pathology of Cancer by Specified Organs and Parts, throughout the World. The ascertainment with approximate scientific accuracy of the geo- graphical incidence of cancer throughout the world is necessarily a difficult and laborious undertaking. In a large measure such an effort at the present time must necessarily prove productive of incomplete and unsatisfactory results for a large portion of the world's surface for which trustworthy vital statistics are not available. The classical attempt on the part of Haviland, in cooperation with William Farr, in 1875, jto establish with scientific exactitude the geographical distribution of can- cer in females in England and Wales suggests the ideal method of statis- tical research, which has only been attained for comparatively small areas of countries with accurate returns of the causes of death. Prinzing in 1908, published the results of a strictly scientific study of cancer frequency in certain administrative subdivisions of WUrttemberg, following an earlier study of a similarly localized excessive cancer mortality in certain portions of South Germany and adjacent parts of Austria and Switzerland.* Hirsch was one of the first to report upon the geographical and historical pathology of cancer, observing at the time As comprehensive a knowledge as possible of the geographical distribution of cancer of the breast and womb is much to be wished, for the sake of the light that it might throw upon the etiology of that most disastrous affliction of the female sex. But every attempted research of geographical pathology in that direction is foiled at the outset by the want of trustworthy statistics of mortality. This was written about 1885, when most of the cancer mortality returns failed to distinguish the organs and parts of the body affected by cancerous growth. In Hirsch's work there are many useful ob- servations, however, which may still be read to advantage, f He re- marks inter alia that The impracticable state of our knowledge when an inquiry is attempted for the whole globe comes out conspicuously, not so much in the want of information as to the exist- ence and prevalence of cancer in many parts of the world, but in the fact that in all but a few instances there is no attention paid to the frequency of the disease in the female sexual organs, or only such terms used as "common" or "rare," which are of equivocal value. Hirsch refers to the conclusion of Haviland that cancer in the female *Dr. Fr. Prinzing: Das Gebiet hoher Krebssterblichkeit in siidlichen Deutschland und in den angrenzendeu Teilen Oesterreichs und der Schweiz. Zeitschrif t fUr Krebsforschung. 5. Band. Berlin, 1907. tHirsch, "Handbook of Geographical and Historical Pathology," London, 1886, Vol. iii, p. 50. 104 CANCER THROUGHOUT THE WORLD sex is rarest in England on hard rock and in high-lying places and commonest on the wet soil of river basins subject to inundations; but he questions the trustworthiness of the material used, for he points out that the generalization is opposed by the fact that in Norway cancer occurs mostly in the mountainous districts and at considerable eleva- tions, to some extent, along the shores of the fiords, but least of all on the open coast. And he further observes that in Mexico the population living on the high table-land is more subject to cancer than the people living on the low plains. Curiously enough, in a brief dis- cussion of the question of cancer increase, Hirsch makes use of the statistics of Frankfurt a/M., "a city which has long been noted for the completeness of its population statistics," where he claims "there has not only been no increase during the last twenty-one years in the fre- quency of those forms of cancer which can be most accurately diagnosed during life or after death^ namely, mammary and uterine cancer, but indeed a considerable decrease when allowance is made for the fact that the population has almost doubled during that period." These con- clusions, however, are not substantiated by the facts.* Davidson in 1892 published the results of an inquiry into the geo- graphical distribution of infective and climatic diseases, in his "Geo- graphical Pathology," in which he gave extended consideration to the frequency of cancer in different countries of the world. The work is of considerable interest and a useful source of reference; but the results were not reduced to a uniform basis of comparison. In the main, how- ever, they reflect the prevailing medical opinion of the period. Clemow in 1903 published a treatise in the Cambridge Geographical Series on "The Geography of Disease," in which cancer is considered briefly and without regard to the need of uniform and strictly comparable statistics. The discussion, however, is otherwise of considerable prac- tical value and in the main confirms the conclusions derived from other sources. Clemow emphasizes the local incidence of the disease in cir- cumscribed areas of certain countries, and he adds many useful ob- servations with regard to cancer frequency among native races, largely based upon the use of material not otherwise so conveniently accessible to the student of the subject.f In none of these cancer surveys for the world as a whole has an attempt been made to consolidate the available material on the basis of standard- ized population estimates and fairly uniform methods of classification. W. R. Williams, in his "Natural History of Cancer," has enlarged upon the geographical aspects of the cancer problem; but his observations also are impaired in value by the non-availability of uniform data for at least the principal countries of the world and for periods of observation at least fairly coincident in point of time. *A further attempt to substantiate the Frankfurt a/M. data by means of special statistical research brought down to date has been made by Prof. Walter F. Willcox, in an address on "The Alleged Increase in Cancer," read at the meeting of the American Public Health Association, December 2, 191-t. The address has not yet been printed, and the data are therefore not available in detail; but apparently the same erroneous classification of internal and external cancers adopted by King and Newsholme was made use of, instead of the classification suggested by Bashford or the method of analysis by specific organs and parts elsewhere made use of in this work. tin 1902 Dr. Irving Phillips Lyon, M.D., of the New YorkPathological Institute madeabriefinvestigation of the geographical distribution of Cancer in Brookfield, Madison Coimty, N. Y., published in the Annual Report of the New York State Board of Health, 1902, as an introduction to a more comprehensive investigation, which, however, has not thus far been made. (See my "Menace of Cancer," page 31.) 105 TEE MORTALITY FROM CANCER Recent International Statistics The purpose of the present work is to meet this requirement, at least in a preUminary form, as a trustworthy basis for a more comprehensive study of cancer as a problem in medical statistics. Efforts have been made in the past to bring together the cancer mortality statistics for different countries and cities, particularly in the special reports of the National Department of Statistics of France and in the Memorial Volume of the Department of Statistics of Amsterdam, prepared for the Dresden International Exposition of Hygiene. These reports, however, give only the general mortality from cancer, that is, without reference to sex, age or organs and parts of the body affected. There is a further limitation in the use of these data, in that they are in some respects wanting in accuracy, apparently, not having in all cases been derived from trust- worthy official sources or been carefully compared with the data pub- lished under official authority. In the present case the statistics are, unless otherwise stated, invariably derived by actual transcript from official reports or they have been secured by direct correspondence, through the courtesy of the officials in charge of the registration of deaths. The populations have been estimated for intercensal years as far as consistent with the known facts of population progress and in a uniform manner; or when this has not been possible, a conservative esti- mate has been arrived at on the basis of all the available information. An effort has been made to provide at least some statistical returns for every important country of the world, or at any rate for the more important cities typical of a region, as an illustration of the local inci- dence of cancer as possibly determined by local conditions. Cancer Throughout the World More or less trustworthy mortality statistics regarding cancer are available for a population of about 450,000,000, which is approximately 26 per cent, of the entire population of the world, estimated for the year 1911. The general cancer mortality by continents, as determined on the basis of the returns for the period 1908-12, was as follows: Mortality from Cancer Registration Countries of the World, 1908-1912* Rate per „ ,. ^ T> 1 *• No. of Deaths .100,000 Continent Population from Cancer Population Africa 9,041,866 3,018 33.4 America 382,549,311 251,438 65.7 Asia 272,814,962 148,447 54.4 Australasia.. 27,886,740 20,345 73.0 Europe 1,431,996,861 1,096,716 76.6 Total 2,124,289,740 1,519,964 71.6 For the period under consideration there was a total population under review of 2,124,289,740 and of this number 1,519,964 died from cancer during the five-year period, a mortality equivalent to 71.6 per 100,000 *The data used in this table are, with a few exceptions, for the period 1908-12 For information in detail, see Tables 4, 217, 232, 259 and 296, Appendix G. 106 CANCER THROUGHOUT THE WORLD of population. The highest rate, 76.6, was for European countries, and the lowest, 33.4, for Africa. For the American continent the rate was 65.7, which is above the rate of 54.4 for Asia and below the rate of 73.0 for Australasia. The statistical data are given in three separate parts: first, for the United States, second, for European countries, and third, for foreign countries other than Europe. The tables for the United States number 259, and for foreign countries 389. The tabular presentation of the data varies considerably, according to local statistical practice, which in most countries limits the returns to the cancer mortality of persons, without reference to sex. As far as practicable, the mortality by age and organs and parts is given in supplementary tables ; and in the case of a few ex- ceptionally interesting countries without vital statistics the cancer morbidity and mortality returns of hospitals are included. A seriously disturbing factor as regards comparability of rates is the occasional limitation, even in important countries, of the death registration to large cities. The practical utility of this world-survey of cancer would, how- ever, have been much diminished if only the countries had been consid- ered for which entirely complete statistics could be obtained. For many important countries, and even for many American States, the accurate registration of vital statistics is limited to large cities, and these are therefore made use of in the absence of more complete returns. It has not been feasible to standardize all the crude cancer death rates for age and sex. This would have involved for many countries an amount of clerical labor which would not only have unduly delayed the publica- tion of this work, but which in all probability would not have materially added to its scientific utility. As an illustration of the effect of such standardization for age and sex the following table is included: Mortality from Cancer Standardized for Age and Sex Constitution, Rate per 100,000 of Population 1906-1910 Crude Standardized Rate Rate England and Wales 94 94 Netherlands 103 93 Australia 70 83 New Zealand 72 81 Austria 78 73 Prussia 74 73 Ireland 79 64 Spain 50 44 Hungary 44 43 It will be observed that the effect of such standardization for age and sex for the more important countries, such as Prussia and Hungary, is almost negligible; the effect is relatively slight for the Netherlands, Austria and Spain; while for the Australian Commonwealth and New Zealand the crude rates are increased. The most important change occurs in the case of Ireland, where abnormal conditions prevail in the age distribution, as a result of a heavy and continuous emigration. 107 THE MORTALITY FROM CANCER The necessity for standardization on account of age and sex in the case of rural communities has elsewhere been discussed. For certain sections of the United States, like Vermont, for illustration, or western Massachu- setts, such a standardization would be necessary to provide a strictly scientific basis of comparison. Since the cancer mortality data for prac- tically all the important countries and cities of the world are for the first time here brought together in a comprehensive form, it should not be difficult to provide a factor for standardization generally applicable to the more scientific study of the facts, if desirable for special purposes. Cancer Frequency in the United States The mortality from cancer in the registration area of the United States is presented in detail in Appendix F (Part 1), in 74 tables. These are followed by 185 tables for the separate states and cities, subse- quently discussed, with the required brevity, but in sufficient detail to emphasize the essentials of the cancer problem for particular localities in the United States. According to Table 2, the cancer death rate of the registration area in 1913 was 78.9 per 100,000 of population. Applied to the estimated total population of the Continental United States, this would represent an aggregate cancer mortality of 76,319; applied to the population of the year 1915, and on the assumption of a slight in- crease in the rate, the approximate cancer mortality for that year may conservatively be placed at 80,000. Tables 3 and 4 are for the states and cities of the registration area, followed by Tables 5 to 28, inclusive, for the separate registration states. The results for the five-year period 1908-12 are summarized in the table below; but for certain states the returns are not for the entire period. Mortality from Cancer Standardized for Age United States Registration Area, 1908-1912 Rate per 100,000 of Population State Crude Standard- Rate ized Rate Massachusetts 93.2 83.6 Rhode Island 86.9 82.7 New York 83.3 89.4 80.4 District of Columbia. 80.4 Minnesota 68.6 74.0 California 84.8 72.6 Connecticut 78.7 70.6 Vermont 102.2 70.0 Maine 100.7 69.8 Wisconsin 72.8 69.7 Maryland 70.3 68.3 State Crude Standard- Rate ized Rate Pennsylvania 65.2 67.8 New Hampshire 97.2 67.8 Ohio 76.4 67.4 Michigan 73.9 65.0 New Jersey 71.8 64.5 Missouri 61.8 61.9 Indiana 70.4 61.7 Colorado 55.8 61.0 Washington 49.5 55.8 Montana 40.6 53.7 Kentucky 43.8 48.3 Local Variations in Cancer Frequency This table is self-explanatory and emphasizes the local variation in the cancer death rate, due, in part, to the varying age constitution of the population of the states considered. The range in crude rates is from a maximum of 102.2 for the state of Vermont to a minimum of 40.6 for the state of Montana, or a difference of 61.6 per 100,000 of population. When standardized for age the range is from 83.6 for the state of Massachusetts to 48.3 for the state of Kentucky, a variation of only 108 CANCER THROUGHOUT THE WORLD 35.3 per 100,000 of population. The rates for Vermont, Maine and New Hampshire experience the greatest change by standardization, for, as is well known, these states contain a relatively high proportion of persons aged 45 and over, partly on account of the absence of large cities.* Since all cancer death rates are primarily a function of age, it is essential to keep this fact in mind; but, as previously pointed out, even when full standardization is made for variations in the age distribution of the population, wide differences in prevailing cancer death rates re- main. There can therefore be no serious question of doubt that the underlying conditions responsible for maximum or minimum cancer death rates are those of the immediate environment as affected by topographical, geological, climatological, sociological, racial, occupational and numerous other conditions, which are as yet but imperfectly known and understood. In view of the debatable borderland of malignancy and innocency in tumor formation, it has seemed advisable to include Table 29, which presents the combined mortality from malignant and benign tumors, estimated for the Continental United States on the basis of the ascer- tained death rate for the registration area, which for the year 1913 was 82.2 per 100,000 of population. Recalling that the estimated number of deaths from cancer for the year 1913 was 76,319, it appears by this table that the combined mortality from malignant and benign tumors for that year was 79,567. Relative Importance of Benign Tumors For the purpose of facilitating the study of these collateral aspects of the cancer problem, Tables 33 to 38, inclusive, present the mortality from benign tumors and certain related causes in detail for the period 1900-13, with distinction of sex and for both sexes combined. The forms of tumors and other diseases included are hydatid tumor of the liver, not specified tumors of other organs of males, tumors of the uterus and ovaries, deaths from ulcer of the stomach, biliary calculi, calculi of the urinary tract, and finally, deaths from all benign tumors combined, estimated at 3,248 for the year 1913. These tables are of unusual interest, in that they furnish the required answer to many debatable questions and the more or less doubtful interpretation of crude cancer mortality statistics. The total mortality from benign tumors, it may be said in this connection, diminished from an average rate of 4.4 in the year 1900 to 3.4 for the year 1913. This reduction may possibly be and probably is, in part, due to a transference of deaths from the benign-tumor class to the malignant-tumor class, as a result of more precise and accurate methods of laboratory diagnosis. But even when it is assumed that the entire reduction in the mortality of benign tumors was thus transferred, the number of deaths thus accounted for could have increased the mor- tality from cancer in the year 1 9 1 3 by only 968 . In contrast, deaths from ulcer of the stomach have increased since the year 1900, when the rate was 2.6, to 4.0 per 100,000 of population for the year 1913. In view of the improved diagnosis of ulcer of the stomach, it would seem quite evident that the increase in the recorded mortality has, in some cases at least, *It may be stated in this connection that the proportion of population ages 45 and over, according to the Census of 1910, was 27.2 per cent, for New Hampshire, 27.1 per cent, for Maine, and 27.0 per cent, for Vermont, compared with 18.6 per cent, for Washington, 17.7 percent, for Kentucky and 16.2 per cent, for Montana. 109 THE MORTALITY FROM CANCER aflPected the mortality from cancer to the extent that deaths which would formerly have erroneously been diagnosed as cancer of the stom- ach or adjacent parts are now more correctly diagnosed as deaths from ulcer of the stomach.* Mortality from Biliary Calculi and Tumors of the Uterus and Ovaries Particularly significant in this connection is the recorded increase in the mortality from biliary calculi and calculi of the urinary tract. The death rate for the former is evidently excessive among females, and the increase in the rate has been greater during recent years; whereas the mortality from the latter is higher among males, but in this case also, the relative increase in the rate has been greater for women than for men. Deaths from benign tumor of the uterus have increased from 2.6 in the year 1900 to 3.8 per 100,000 of female population in 1913, but the rate has been subject to considerable fluctuations, and on the whole may be said to have been rather stationary. Deaths from tumor of the ovaries appear to have diminished; but here also, considering the small- ness of the rate, the changes have not been of material importance. Tables 31 and 32 differentiate the mortality from cancer in the registration area of the United States by sex. For the year 1913 the male cancer death rate was 61.3 and the female rate was 97.6. The excess of the female rate of the cancer deaths for that year was therefore 36.3 per 100,000 of population, or 59.2 per cent. Tables 41 to 46, inclusive, show the mortality from cancer by groups of organs and parts, according to sex, in conformity to the International Classification of causes of death. The results for the period 1908-12 are briefly summarized in the table below. Mortality from Cancer, by Organs and Parts, according to Sex United States Registration Area, 1908-1912 Rate per 100,000 Population Organ or Part Total Males Females Buccal cavity 2.8 4.6 1.0 Stomach and liver 29.6 28.8 30.5 Peritoneum, intestines and rectum . 9.5 7.7 11.3 Female generative organs 11.4 . . 23.4 Female breast 7.0 . . 14.3 Skin 2.8 3.5 2.1 Other or not specified organs 11.6 13.2 10.0 All organs and parts 74.7 57.7 92.6 Aggregate Mortality from Tumors The total mortality from cancer in the Continental United States has been estimated on the basis of the actual rates by groups of organs and parts for the registration area for the year 1913. These estimates are here given only in a summary form. The details for each group for single years since 1900 are given in Table 47, Appendix F, (Part 1). *The pathologic relationship of gastric ulcer and carcinoma has been made the subject of a special and ex- tended investigation by the Mayo Clinic of Rochester, Minn. The evidence of such a relationship appears to have been conclusively established, as brought out by fifteen micro-photographs of specimen cases exhibited on the occasion of the meeting of the American Medical Association, Atlantic City, 1914. 110 CANCER THROUGHOUT THE WORLD Estimated Total Mortality from Cancer, by Organs and Parts Continental United States, 1913 Rate per Number 100,000 of Percentage Organ or Part Population Deaths Distribution Buccal cavity 3.11 3,007 3.94 Stomach and liver 31.23 30,215 39.59 Peritoneum, intestines and rectum. 10.47 10,128 13.27 Female generative organs 12.17 11,776 15.43 Breast 7.25 7,021 9.20 Skin 2.73 2,633 3.45 Other or not specified organs 11.92 11,539 15.12 All organs and parts 78.88 76,319 100.00 Increase by Organs and Parts of the Body The analysis in detail of these tables amply supports the conclusion not only that cancer in the aggregate is on the increase, but that there has been a rise in the recorded and specified cancer death rate in the United States for every important group of organs or parts of the body affected by malignant disease. During the period 1900-12 cancer of the buccal cavity increased from 1.6 to 3.0; cancer of the stomach and liver, from 22.5 to 30.6; cancer of the peritoneum, intestines and rectum, from 5.7 to 9.8; cancer of the female generative organs, from 8.8 to 11.7 (or on the basis of female population, from 17.5 to 24.2) ; cancer of the female breast increased from 4.5 to 7.2 (or on the basis of female popu- lation, from 9.1 to 14.9) ; cancer of the skin, from 2.0 to 2.9; but cancer of other organs and parts decreased from 17.9 to 11.7. This decrease, of course, is of considerable importance, in that practically the whole of it affects the increase in the cancer mortality of specified organs and parts ; but it will be observed by reference to Table 46 that this de- crease has practically come to an end since 1908, and although the total cancer death rate during this period has increased from 71.5 to 77.0, all of this increase has fallen upon specified organs and parts, which it is safe to assume are at the present time not subject to very material alterations in precise diagnosis, or in any event not sufficiently so to account for this considerable augmentation of the cancer death rate during so short a period as five years. To facilitate the scientific study of the cancer death rates, the popula- tion statistics for the registration area by sex and ages are given in full detail in Table 48. This table shows separately the estimated population for the decade ending with 1912 and the two quinquennial periods ending with 1907 and 1912. Since for medical purposes cancer death rates for ages 45 and over are most useful, the aggregate population for this age period is given separately; to facilitate comparison with the English statistics by age, the divisional periods of life have been arranged in a corresponding manner, and also, of course, in conformity to the age grouping adopted by the United States Census Office. Cancer Increase by Age and Sex Tables 49 to 55, inclusive, present the cancer mortality of the United States registration area for the decade ending with 1912, by sex and divisional periods of life, for all forms of cancer as well as for the separate 111 THE MORTALITY FROM CANCER groups of organs and parts. These tables should prove of exceptional practical utijiity especially in the medical study of the cancer problem, as regards the true incidence of different forms of cancer frequency ac- cording to age and sex. The results for cancer of all organs and parts of the body are summarized in the following table: Mortality from Cancer, by Age and Sex, United States Registration Area 1908-1912 Males Rate per Ages 100,000 Under 10 2.5 10-24 3.1 25-34 9.0 35-44 32.3 45-54 105.4 55-64 257.4 65-74 452.8 75 and over 620.2 All ages* 55.7 45 and over 236.5 Females Rate per 100,000 2.2 2.8 20.6 89.0 222.9 386.4 565.7 734.1 90.6 366.4 Excess or Deficiency in the Female Rate Compared with the Male Rate Per Cent. + + Actual - 0.3 - 0.3 11.6 56.7 + 117.5 + 129.0 + 112.9 + 113.9 + 34.9 + 129.9 — 12.0 — 9.7 + 128.9 + 175.5 + 111.5 + 50.1 + 24.9 + 18.4 + + 62.7 54.9 *Including unknown ages. Briefly, it is shown that the cancer mortality of females exceeds the cancer mortality of males at all ages over 24. The actual excess is most pronounced at ages 55 to 64, but the relative excess is greatest at ages 35 to 44, when the cancer mortality of females is 175.5 per cent, in excess of the cancer mortality of males. At ages 45 and over the cancer death rate of males is 236.5, but of females it is 366.4. There is, therefore, an actual excess in the female cancer death rate of 129.9 per 100,000 of population, equivalent to 54.9 per cent. The excess in the female cancer death rate is primarily due to the excessive frequency of cancer of the female generative organs and the breast. Proportionate Cancer Mortality in the United States The study of the subject may be approached from another point of view, but with less assurance of accuracy in the results. For certain purposes, however, the proportionate mortality is of value when the correct rate of incidence can not be determined on the basis of the existing population of corresponding ages. Table 57 has therefore been in- cluded, but the results are given only in a summary form for the five years ending with 1912, and according to sex and by five-year periods of life, subsequently summarized for ages under 15, ages 15 to 44, ages 45 to 64, and 65 and over. The proportionate mortality as determined by this method for ages 45 to 64 was 7.8 per cent, of the deaths from all causes for males, and 16.8 per cent, for females. In a similar manner the relative mortality from cancer in comparison with that from other important causes of death has been summarized in Table 58 for ages under 45, and 45 and over, with distinction of sex. This table should prove particularly useful in discussions of public-health problems, for the purpose of visualizing the relative importance of cancer 112 CANCER THROUGHOUT THE WORLD as a leading cause of death in adult life demanding a much more active interest on the part of the medical and surgical profession and the laity than has heretofore been the case. Cancer Mortality by Season The cancer death rate is apparently but very slightly, at least in the United States, affected by season, or the months of the year. Table 59 has been included as a brief contribution to this phase of the cancer problem, the same being based upon the returns for the decade ending with 1911 of the states of New York, Massachusetts, New Hampshire and Connecticut. The range in the monthly cancer death rate was from a minimum of 6.3 for January and June to a maximum of 6.7 for August and October. The monthly average rate for the year was 6.5. Details of Increase by Organs and Parts of the Body The increase in cancer, as shown by the annual returns for the American States and the registration area as a whole, is more accurately disclosed by the specialized analysis of data for the registration area, first, for all forms of cancer according to age and sex, and second, for the six principal groups of specified organs and parts. To avoid too elaborate a method of comparison, it has been considered sufficient to limit the same to the two five-year periods ending with 1907 and 1912. The details of this analysis are set forth in Tables 61 to 74, inclusive, in a uniform manner, showing in each case the actual number of deaths from cancer and the rate per 100,000 of population by divisional periods of life. The population data used in this analysis are given in full in Table 48. These tables are of exceptional medical and surgical interest, and they will meet practically every reasonable requirement for a more adequate discussion of the statistical aspects of the cancer problem, with special reference to the United States at the present time. It has not been feasible to summarize the results of these tables, but in brief they may be said to confirm the broad conclusion that cancer is on the increase in the United States, not only when considered in the aggregate, but when every important form of cancer or organ or part of the body affected locally by malignant disease is separately considered. There are, however, probably some important exceptions to this far-reaching conclusion, which unfortunately, on account of the lack of adequate data can not be conclusively established by the statistical method at the present time. The reason for this limitation is to be found in the transfer of cancer deaths from the formerly rather large not-specified group to the groups of cancer of specified organs and parts. It may be pointed out in this connection that, regardless of a general tendency towards cancer increase, there has been a decrease in cancer frequency among males at ages 10 to 44 and among females at ages 25 to 54, when the rates for the five-year period ending with 1912 are compared with the rates for the five-year period ending with 1907. The mortality from cancer of the buccal cavity remains practically the same at all age periods for males at ages under 45 and for females at ages under 55, excepting ages 10 to 24. This interesting result is probably, in part at least, attributable to the generally successful operative treatment for this form of cancer. There was either a very 113 THE MORTALITY FROM CANCER slight actual increase or decrease in the mortality of both sexes from cancer of the stomach at ages under 55. This likewise is of much practical significance, and again, it is a safe conclusion that the reduction is primarily the result not of diminished liability to cancerous affections, but to a reduced mortality in consequence of successful operative and medical treatment. At ages 55 and over, there has been a considerable increase in the mortality from cancer of the stomach and liver in recent years, and for both sexes. For males the percentage increase was 12.0, ages 55 to 64; 12.4, ages 65 to 74; and 27.3, ages 75 and over. For females the percentage increase was 14.3, ages 55 to 64; 14.4, ages 65 to 74; and 26.3, ages 75 and over. In contrast, the mortality from cancer of the peritoneum, intestines and rectum has increased for both males and females at every period of life above the age of 10. Cancer of the female generative organs has increased at every divisional period of life and cancer of the female breast at all ages over 25. It is significant that the mortality from cancer of the breast at ages under 25 should have been stationary, when deaths, though rare, are liable to occur. Cancer of the skin has increased for males at all ages, while for females the rate has shown only very slight changes at all ages under 65. The mortality from cancer by organs and parts not specified has decreased for both sexes at every divisional period of life. The correct interpretation of these statistics is rather difficult and more extended returns will be required before it will be safe to employ more refined methods of analysis; but the data seem to admit of no exception to the important and far-reaching conclusion that the mortality from cancer of all important organs and parts, and for both sexes, has increased more or less at all ages over 50, when, of course, numerically, the mortality from malignant disease is of the greatest practical significance. Age Incidence of Cancer To further facilitate the study of the age incidence of cancer fre- quency in the registration area of the United States, Table 60 is included. This table exhibits the crude and standardized death rates per 100,000 of population of the states included in the registration area in 1900, compared for the years 1901 and 1911, and the relative mortality for 1911, on a percentage basis, compared with that for 1901. It is shown by this table that for both sexes at ages 25 and over the cancer death rate of 1911 was 25 per cent, in excess of the rate for 1901. For males the rate for 1911 was 29 per cent, in excess, and for females, 23 per cent. This table is derived from the Census Report on mortality statistics for 1911. For all of the other tables of the United States only the original data are derived from the Census publications, the rates in every case having been recalculated and rearranged for the present purpose, so as to make the comparison uniform, as far as practicable, not only for the several states and cities, but also for foreign countries.* Cancer Mortality Data of the New York Pathological Institute Under an arrangement with the New York State Board of Health, the New York State Institute for the Study of Malignant Disease receivedf *Tlie mortality froin sarfoiiia and from all other forms of cancer are given in full, by single years of life, in Appendix D, Experience Data of American and Foreign Life Insurance Companies. fAccording to an ofiBcial statement the cooperative arrangement between the State Institute for the Study of Malignant Disease and the Slate Board of Health was unfortunately diuicontinued subsequent to June, 1914. 114 CANCER THROUGHOUT THE WORLD a transcript of the official certificate of every death from cancer, including some additional data of special interest. The returns, more or less com- plete, have been received under this agreement from every county and city of the state, except Greater New York, for the year 1913.* The number of deaths from cancer returned in this manner was 2,041, of which 1,733, or Q5.5 per cent., were deaths of women. A summary statement by organs and parts of the body affected is given below : Analysis of Cancer Deaths in the State of New York (Excepting Greater New York) as Returned to the New York State Institute for the Study of Malignant Disease, 1913t Males Females Organ or Part Number Per Cent. Number Per Cent. Buccal cavity 92 10.1 14 0.8 Stomach and liver 400 44.1 544 31.4 Peritoneum, intestines, rectum . 137 15.1 220 12.7 Female generative organs . . 456 26.3 Breast 5 0.5 314 18.1 Skin 5Q 6.2 27 1.6 Other organs and parts . 218 24.0 158 9.1 Total 908 100.0 1,733 100.0 fSee blank form used in Table 3, Appendix B. The returns are classified in detail in this chapter, according to which there were 66 specified organs or parts of the body affected, the largest number of deaths of males from cancer having been due to cancer of the stomach, which accounted for 281, or 30.9 per cent, of the total deaths of males from malignant disease. Cancer of the uterus accounted for the largest number of deaths from cancer among women, or 23.1 per cent, of the total deaths from cancer of all organs and parts of the body. The New York State investigation for the first time throws light upon the approximate previous duration of cancer, and the summary table below illustrates the general results, according to sex : Previous Duration of Malignant Disease, according to Sex New York State Institute for the Study of Malignant Disease, 1913 Males Females Duration Number Per Cent. Number Per Cent. Under 1 year 321 39.4 465 29.6 1 to 4 years 465 57.2 1,003 64.0 5 years and over . . 28 3.4 98 6.4 Total stated 814 100.0 1,566 100.0 *0f the 4,313 deaths from cancer occurring in New York state (Greater New York excluded) in 1913, returns for 2,C41 were made to the New York State Institute for the Study of Malignant Disease. 115 THE MORTALITY FROM CANCER Of the male deaths from cancer 39.4 per cent, show a previous dura- tion of disease of less than one year, against 29.6 per cent, of the female deaths. The percentage of deaths with a previous disease duration of five years or more was 3.4 for males and 6.4 for females. The large ma- jority of cancer deaths followed a previous duration of from six to twenty -four months. The average duration of previous disease was 22 months for males and 26 months for females. The New York State investigation also includes an inquiry into the previous family history of cancer. The table following briefly summarizes the results : Family History of Cancer or Heredity New York State Institute for the Study of Malignant Disease, 1913 Males Females Family History Number Per Cent. Number Per Cent. Yes 104 12.5 245 16.1 No 731 87.5 1,279 83.9 Total stated 835 100.0 1,524 100.0 Notstated 73 .. 209 Grand total 908 .. 1,733 It is brought out by this table that definite evidence of a family history from cancer was obtained in 12.5 per cent, of cancer deaths of males, against 16.1 per cent, of cancer deaths of females. Another impor- tant result of the New York State inquiry is information regarding the microscopical examination of cancerous tissue. It was brought out that of the male cases of cancer 21.9 per cent, had been diagnosed upon the basis of microscopical findings, against 23.2 per cent, of the female cases. Primary Seat of Growth, Probable Cause and Personal History Some extremely interesting details disclosed by investigation re- garding the primary seat of growth, the probable cause and the personal history are summarized for the more important organs, below: Cancer of the Bladder. Males: 32 deaths; average age, 64 years. Primary seat of growth: bladder, 27; prostate, 4; ureter, 1. Probable cause: trauma, 4; urinary calculi, 1; enlarged prostate, 1; venereal disease, 1. Personal history: alcoholism, 6; enlarged prostate, 1; syphilis, 1; tuberculosis, 1. Females: 18 deaths; average age, 65 years. Primary seat of growth: bladder, 15; labia, 1; uterus, 1; urethra, 1. Probable cause: calculi, 1; cervical tear, 3; urethral carbuncle, 1. Cancer of the Female Breast. 314 deaths; average age, 61 years. Primary seat of growth: breast, 304; axilla, 5; lung, 2; scapula, 1; uterus, 1; not stated, 1. Probable cause: trauma, 44 ; childbirth, 13; mastitis, 7; tumor of breast, 5; abscess of breast, 2; ulcerated nipple, 1; fissure breast, 1. Personal history: tuberculosis, 13; alcoholism, 3; syphilis, 2. 116 CANCER THROUGHOUT THE WORLD Cancer of the External Female Organs of Generation. 16 deaths; average age, 72 years. Primary seat of growth: vulva, 7; labia, 7; others, 2. Probable cause: ulcer, 2; gonorrhoeal warts, 1; cervical tear, 1; prolapse uterus, 1 ; eczema, 1. Personal history : gonorrhoea, 1 ; gall- stones, 1; cystitis, 1; psoriasis, 1; diabetes, 1. Cancer of the Gall-bladder. Males: 8 deaths; average age, 66 years. Primary seat of growth: gall-bladder, 8. Probable cause: gall- stones, 3; trauma, 1. Females: 24 deaths; average age, 68 years. Primary seat of growth: gall-bladder, 23; not stated, 1. Probable cause: gall-stones, 7; trauma, 1; gastric ulcer, 1. Personal history: cholelithiasis, 7; indigestion, 1. Cancer of the Intestines. Males: 75 deaths; average age, 63 years. Primary seat of growth: intestines, 62; stomach, 4; rectum, 3 bladder, 1; liver, 1; mesentery, 1; peritoneum, 1; not stated, 2 Probable cause : trauma, 9; ulcer of stomach, 3; ulcer of intestines, 2 appendicitis, 1. Personal history: alcoholism, 12; tuberculosis, 3 constipation, 3; gall-stones, 1; hernia, 1; enlarged prostate, 1 Females: 166 cases; average age, 62 years. Primary seat of growth intestines, 131; uterus, 9; stomach, 6; breast, 5; fallopian tube, 1 gall-bladder, 1; rectum, 1; ovary, 1; spleen, 1; pancreas, 1; peri- toneum, 1. Probable cause : trauma, 5 ; appendicitis, 3 ; childbirth, 3 ; metritis, 2; typhoid, 1 ; ulcer, 1 ; mastitis, 1 ; gastric ulcer, 1 ; hernia, 1. Personal history: indigestion, 10; tuberculosis, 6; alcoholism, 1; ovarian disease, 2; hernia, 1. Cancer of the Jaw. Males: 30 deaths; average age, 65 years. Primary seat of growth: jaw, 19; gums, 3; lip, 3; tongue, cheek, tooth, mouth and not stated, 1 each. Probable cause: teeth, 7; smoking, 4. Personal history : alcoholism, 8; cancer of jaw, abscess of jaw and tuberculosis, 1 each. Females: 7 deaths; average age, 66 years. Primary seat of growth: jaw, 5; eye, 1; nose, 1. Probable cause: ulcerated tooth, 1; smoking, 1; mole, 1. Personal history: tuber- culosis, 1. Cancer of the Kidneys. Males: 11 deaths; average age, 59 years. Primary seat of growth : kidney, 10 ; cheek, 1 . Probable cause : gonorrhoea, 1 ; trauma, 1; abscess of kidney, 1. Personal history: alcoholism, 2; appendicitis, 1. Females: 3 deaths ; average age, 55 years. Primary seat of growth : kidney, 3. Personal history : tuberculosis, 1. Cancer of the Lips. Males: 22 deaths; average age, 74 years. Primary seat of growth: lips, 20; jaw, 2. Probable cause: smoking, 14; cut lip, 1; ulcer of lip, 1; wart, 1; tooth, 1. Personal history: alcoholism, 3; syphilis, 1. Cancer of the Liver. Males: 89 deaths; average age, 62 years. Primary seat of growth: liver, 69; stomach, 6; gall-bladder, 2; testicle, 2; cheek, spleen, abdomen, rectum, eye and axilla, 1 each; not stated 4. Probable cause: trauma, 8; gastritis, 3; rich food, ulcer of stomach, - lead-po isoning, gall-stones, indigestion, prostatitis and appendicitis, 1 eachTTersonal history: alcoholism, 12; tuberculosis, 4 ; syphilis, 4. Females: 184 deaths ; average age, 63 years. Primary seat of growth : liver, 126; gall-bladder, 23; breast, 13; stomach, 6; uterus, 4; mesentery, 2; kidney, ear, pancreas, colon, rectum and ovary, 117 THE MORTALITY FROM CANCER 1 each; not stated, 4. Probable cause: gall-stones, 13; cervical tear, 5; trauma, 6; childbirth, 6; ulcer of stomach, 2; abscess of liver, cancer of lip, cancer of ear and ulcer of intestines, 1 each. Personal history: tuberculosis, 8; alcoholism, 5; congestion of liver, syphilis and icterus, 1 each. Cancer of the Lungs. Males: 6 deaths; average age, 61 years. Primary seat of growth: lung, stomach, axilla and thigh, 1 each; not stated, 2. Probable cause: trauma, 3; gastric ulcer, 1. Females: 11 deaths; average age, 55 years. Primary seat of growth : breast, 9; shoulder, 2. Probable cause: trauma, 2; pneumonia, 1; cancer of breast, 1. Personal history: tuberculosis, 2. Cancer of the Mouth. Males: 8 deaths; average age, 72 years. Primary seat of growth: jaw, 5; gums, 1; cheek, 1; lip, 1. Probable cause: ulcer of tooth, 5; smoking, 2. Personal history: tuberculosis, 1; eczema, 1. Cancer of the Neck. Males: 26 deaths ; average age, 63 years. Primary seat of growth: neck, 17; maxilla, 2; lip, 2; larynx, cervical gland, collar bone, parotid and skin, 1 each. Probable cause : smoking, 2; strain, 1; cat scratch, 1. Personal history: alcoholism, 7; tuberculosis, syphilis and cancer of neck, 1 each. Females: 5 deaths ; average age, 67 years. Primary seat of growth: parotid, breast, nose, neck and sub-maxillary, 1 each. Probable cause: smoking, 1. Personal history : alcoholism, 1. Cancer of the (Esophagus. Males: 16 deaths; average age, 58 years. Pri- mary seat of growth : oesophagus, 13; stomach, 2; not stated, 1. Prob- able cause : smoking, 1 ; rapid eating, 1 . Personal history : alcoholism, 5; paralysis, 1. Females: 10 deaths; average age, 64 years. Primary seat of growth : oesophagus, 8 ; larynx, 1 ; breast, 1. Personal history : tuberculosis, 1 ; alcoholism, 1. Cancer of the Ovaries. 21 deaths; average age, 54 years. Primary seat of growth: ovaries, 17; breast, stomach, uterus and not stated, 1 each. Probable cause: childbirth, 4; ovarian cyst, 1. Personal history : gonorrhoea, 1 ; pelvic inflammation, 1 ; tuberculosis, 2. Cancer of the Pancreas. Males: 18 deaths; average age, 59 years. Primary seat of growth: pancreas, 14; stomach, abdomen, liver and not stated, 1 each. Probable cause : trauma, 2. Personal history : alcoholism, 1. Females: 24 deaths; average age, 64 years. Primary seat of growth: pancreas, 18; gall-bladder, 1; epigastrium, 1; not stated, 4. Probable cause: gall-stones, 3; prolapse of uterus, 1; miscarriage, 1. Personal history: tuberculosis, 2; pancreatitis, 1; goitre, 1. Cancer of the Peritoneum. Males: 6 deaths; average age, 47 years. Primary seat of growth: peritoneum, ureter, retro-peritoneal gland, testicle, mesentery and not stated, 1 each. Probable cause : trauma, 1; gonorrhoea, 1. Personal history: syphilis, 1; asthma, 1. Females: 6 deaths; average age, 52 years. Primary seat of growth: perito- neum, sigmoid, bladder and pelvic organs, 1 each; not stated, 2. Probable cause: perineal tear, 1. Personal history: syphilis, 1; gastritis, 1. 118 CANCER THROUGHOUT THE WORLD ( ^anccr of the Pharynx. Males: 6 deaths ; average age, 60 years. Primary seat of growth: pharynx, 2; jaw, 2; tonsil, 1; mouth, 1. Probable cause: smoking, 3; tooth-extraction, 1; ulcer of gum, 1. Personal history: alcoholism, 2. Cancer of the Prostate Gland. 36 deaths ; average age, 70 years. Pri- mary seat of growth : prostate, 35 ; urethra, 1 . Probable cause : pros- tatitis, 3; stricture of urethra, 2; trauma, 1; gonorrhoea, 1. Personal history: alcoholism, 8; sexual excess, syphilis, tuberculosis and hernia, 1 each. Cancer of the Rectum. ifcfaZes; 56 deaths; average age, 63 years. Primary seat of growth: rectum, 46; prostate, 3; lip, sigmoid, bladder and hip joint, 1 each; not stated, 3. Probable cause: piles, 5; trauma, 3; diarrhoea, 2; prostatitis, 1. Personal history: lead-poisoning, 1; alcoholism, 5. Females: 48 deaths; average age, 62 years. Primary seat of growth: rectum, 42; ovaries, 4; sigmoid, 1; uterus, 1. Prob- able cause : trauma, 4 ; cervical tear, 4 ; rectal ulcer, 1 ; childbirth, 2 ; constipation, 1; piles, 3; pruritus ani, 1. Personal history: tuber- culosis, 1 ; diabetes, 1 ; uterine fibroid, 1. Cancer of the Skin. Males: 56 deaths; average age, 71 years. Primary seat of growth : nose, 9 ; ear, 9 ; face, 7 ; eye, 7 ; cheek, 6 ; lip, 5 ; maxilla, 3 ; temple, mastoid, teeth and sacrum, 1 each ; not stated, 6 . Probable cause: trauma, 14; smoking, 3; mastitis, cleft palrte, ulcer of tooth, irritation from glasses, ulcer of nose and irritation, 1 each. Personal history: alcoholism, 9; tuberculosis, 1; cataract, 1; appendicitis, 1. Females: 27 deaths; average age, 72 years. Primary seat of growth: nose, 8; cheek, 7; face, 3; eye, 3; scalp, 2; lip, ear, forehead and parotid glands, 1 each. Probable cause: lupus, growth on ear, pick- ing of face, trauma and ulcer of nose, 1 each. Personal history: tuberculosis, 2; alcoholism, 1. Cancer of the Stomach. Males: 281 deaths; average age, 63 years. Primary seat of growth: stomach, 263; oesophagus, 5; intestines, 3; spine, liver, nose, kidney, abdomen, rectum, lip, pancreas, penis and testicle, 1 each. Probable cause: ulcer of stomach, 50; trauma, 19; gastritis, 3; overeating, 1; cancer of hip, 1. Personal history: alcoholism, 48; tuberculosis, 5; syphilis, 5; indigestion, 3; stomach- trouble, 2; gall-stones, cirrhosis of liver, enlarged prostate, hepatitis, lead-colic, jaundice and hydrocele, 1 each. Females: 326 deaths; average age, 64 years. Primary seat of growth: stomach, 284; breast, 22; uterus, 3; intestines, face and gall-bladder, 2 each; liver, hernia, forehead, eye, kidney, mesentery, spleen, nose, pancreas, pharynx and ovary, 1 each. Probable cause: ulcer of stomach, 49; childbirth, 17; trauma, 8; alcoholism, 4; gall-stones, 2; removal of breast, 2; ulcer of leg, hernia, cancer of breast, removal of kidney and hysterectomy, 1 each. Personal history: indigestion, 15; tuberculosis, 7; gastritis, 2; typhoid fever, 2; uterine fibroid, 1; syphilis, 1. Cancer of the Throat. Males: 16 deaths; average age, 66 years. Primary seat of growth: tongue, 3; lip, 3; larynx, 3; maxilla, 2; tonsil, palate, 119 THE MORTALITY FROM CANCER cheek, oesophagus and pharynx, 1 each. Probable cause: pipe, 7; ulcerated tooth, 2; trauma, 1. Personal history: alcoholism, 5; syphilis, 1. Females: 5 deaths; average age, 62 years. Primary seat of growth: larynx, 2; tonsil, oesophagus and thyroid, 1 each. Cancer of the Tongue. Males: 23 deaths; average age, 68 years. Primary seat of growth: tongue, 18; lip, 2; maxilla, 1; tonsil, 1; not stated, 1. Probable cause: smoking, 12; irritation from tooth, 3. Personal history: alcoholism, 6; syphihs, 1. Females: 4 deaths, average age, 55 years. Primary seat of growth: tongue, jaw, tonsil and not stated, 1 each. Probable cause: smoking, 1. Cancer of the Uterus. 401 deaths; average age, 55 years. Primary seat of growth: uterus, 374; ovaries, 5; breast, 2; intestines, 2; round ligament, 1; not stated, 17. Probable cause: cervical tear, 141; childbirth, 54; ulcer of uterus, 5; fibroid uterus, 4; trauma, 2; ovarian cyst, previous cancer and vaginal irritation, 1 each. Per- sonal history: syphilis, 10; tuberculosis, 7; alcoholism, 4; uterine prolapse, 4; gonorrhoea, 2; pelvic disease, 2; salpingitis, uterine laceration, cancer of breast, gall-stones, vaginal fistula, gastric ulcer and endometritis, 1 each. Cancer of the Vagina. 11 deaths; average age, 59 years. Primary seat of growth: vagina, 9; uterus, 2. Probable cause: vaginal ulcer, operation on uterus, childbirth, tumor and irritation from pessary, 1 each. Personal history : alcohoUsm, 1 ; syphilis, 1. Primary Seat of Growth and Other Organs and Parts Involved The primary organs or parts affected and the number of other organs and parts involved, according to sex, for the principle organs and parts, according to the New York State investigation, were as follows : Cancer of the Bladder. Males: 32 deaths. Other involvements: ab- domen, 1; pancreas, 1; prostate, 3; rectum, 1. Females: 18 deaths. Other involvements: abdomen, inguinal gland, intestines and urethra, 1 each; uterus, 2. Cancer of the Breast. Males: 5 deaths. Other involvements: liver, 1. Females: 314 deaths. Other involvements: arm, 3; axilla, 5; cevxical glands, kidney, larynx, shoulder, skin and uterus, 1 each; intestines, 2; liver, 15; lung, 12; mediastinum and pleura, 4 each; neck and vertebra, 3 each; stomach, 11. Cancer of the External Female Generative Organs. 16 deaths. Other in- volvements: bladder, glandular, liver, pehdc organs and not speci- fied, 1 each; inguinal gland, 4. Cancer of the Gall-bladder. Males: 8 deaths. Other involvements: intestines, 1; liver, 6. Females: 24 deaths. Other involvements: intestines and stomach, 2 each; liver, 12. Cancer of the Intestines. Males: 75 deaths. Other involvements: bladder, peritoneum and stomach, 1 each; liver, 5. Females: 166 deaths. Other involvements: abdomen, femur, liver, mediastinum and ovaries, 1 each ; bladder and rectum, 2 each; stomach, 7; uterus, 4. 120 CANCER THROUGHOUT THE WORLD Cancer of the Liver. Males: 89 deaths. Other involvements: intestines, pancreas, rectum, spleen, testis and thorax, 1 each; stomach, 5. Females: 184 deaths. Other involvements: brain, lung, pancreas, peritoneum and uterus, 1 each; breast, 4; gall-bladder, 3; intestines, 13; stomach, 5. Cancer of the Lungs. Males: 6 deaths. Other involvements: lower ex- tremity, stomach and thorax, 1 each. Females: 11 deaths. Other involvements: axilla, mediastinum, pleura and spleen, 1 each; breast, 3. Cancer of the Month. Males: 8 deaths. Other involvements: jaw and stomach, 1 each; throat, 3. Females: 1 death. Other involve- ments: antrum, 1. Cancer of the Ovaries. 21 deaths. Other involvements: intestines, 4; pelvic organs (not specified), pleura, rectum and uterus, 1 each. Cancer of the Pancreas. Males: 18 deaths. Other involvements: in- testines, spleen and stomach, 1 each; liver, 2. Fetnales: !24 deaths. Other involvements: gall-bladder, intestines, liver and stomach, 1 each. Cancer of the Rectum. Males: 56 deaths. Other involvements: bladder and intestines, 3 each; liver, 2. Females: 48 deaths. Other in- volvements : bladder, 2 ; breast, intestines, liver, pelvis, peritoneum, stomach and vagina, 1 each. Cancer of the Skin. Males: 5Q deaths. Other involvements: eye, in- testines, neck, prostate gland and throat, 1 each. Females: 27 deaths. Other involvements : eye and throat, 1 each. Cancer of the Stomach. Males: 281 deaths. Other involvements: in- testines, 5; Kver, 26; neck, 1; oesophagus and pancreas, 2 each. Females: 326 deaths. Other involvements: breast, lung, pancreas and pelvic organs (not specified), 1 each; femur and intestines, 2 each; liver, 21; uterus, 3. Cancer of the Tongue. Males: 23 deaths. Other involvements: jaw and mouth, 1 each; pharynx and throat, 2 each. Females: 4 deaths. Other involvements : mouth and skin, 1 each. Cancer of the Uterus. 401 deaths. Other involvements: abdomen, 2; bladder and ovaries, 5 each; breast, external female organs of generation, kidney and throat, 1 each; intestines, liver and pelvis, 3 each; rectum, 9; stomach, 7. Cancer of the Vagina. 11 deaths. Other involvements: ovaries and rectum, 1 each; pelvis, 2; uterus, 3. The results of this investigation are for the time being of limited value, on account of the paucity of the data considered; but the method em- ployed suggests the direction which inquiries of this kind should take to establish with greater accuracy certain special but fundamental numer- ical facts of the cancer problem.* *The blank used by the New York State Institute for the Study of Malignant Disease is given in Appen- dix B. All the obseri'ations and conclusions regarding the data collected by the New York State Institute for the Study of Malignant Disease are based upon this analysis, made under my personal direction, of the original records loaned for this purpose by the Institute through the kindness of Dr. H. R, Gaylord and his associates. 121 THE MORTALITY FROM CANCER Geographical Pathology of Cancer by Organs and Parts The cancer death rate varies so widely throughout the civihzed world that the argument is frequently advanced that the rate of frequency is primarily determined by the accuracy and completeness of death regis- tration; in other words, a low cancer death rate is assumed to be evidence rather of a backward state of medical practice or a disregard of funda- mental requirements in the registration, tabulation and analysis of vital statistics. Yet it is perfectly well known that certain forms of cancer prevail in some parts of the world which are practically unknown in other parts and that certain types of malignant disease are quite common in certain occupations and absolutely unknown in others. It is, therefore, a valid assumption that there may be local reasons for cancer rarity or cancer frequency, irrespective of the always important question as to whether the registration of deaths is both accurate and complete. Kangri cancer is practically unknown outside of a comparatively circum- scribed area of Asia; cancer of the cheek, attributed to the chewing of the betel nut, is extremely rare outside of India; cancer of the male generative organs is common in that country, but very rare in Europe and America; chimney-sweeps' cancer is practically limited to the IJnited Kingdom; Roentgen-ray cancer is entirely limited to X-ray workers, etc. These forms of cancer are all comparatively easy of accurate diagnosis, but they forcibly emphasize the conclusion that not only is cancer invariably, to begin with, a strictly local affection, but that certain forms and possibly all types of malignant disease may be determined by local conditions, or what is generally comprehended under the term environment. There are no reasons known why cancer should not be comparatively rare among native races; but many reasons exist why cancer should be relatively common among the peoples of civilized nations, living more or less under artificial conditions of existence. A low cancer death rate is, therefore, not an inherent improbability or necessarily evidence of faulty diagnosis or imperfect death registration. The statistical evidence in support of this conclusion is extremely in- teresting and, as far as known, the facts have not heretofore been brought together in a convenient form.* A comparative study in detail of the geographical pathology of cancer throughout the world, by specified organs and parts of the body, would be impracticable and possibly inconclusive at the present time. The returns for certain organs and parts, however, are quite comparable for the principal countries of the world, and for the present purpose, cancer of the stomach, including the liver and the oesophagus, cancer of the skin, cancer of the female generative organs and of the female breast have been selected to illustrate the wide range in variation of cancer *As an additional illustration of the relatively higher degree of cancer frequency among the well-to-do, reference may be made to the recently published statistics of the city of Edinburgh, Scotland. Grouping the deaths from cancer and from tuberculosis according to the rental paid for the houses in which the deaths oc- curred, it appears that as regards cancer 35.9 per cent, of the deaths occurred in houses with the highest rental (over $100 a year), 37 per cent, occurred in the houses with the moderate rental ($50 to $100 a year) and 21.8 per cent, occurred in the houses with the lowest rental (less than $50 a year). In contrast, the distribution of deaths from tuberculosis, which is largely a disease of poverty, was as follows : 17.9 per cent, of the deaths occurred in the houses with the highest rental ; 34.6 per cent, in the houses with the moderate rental, and 36.4 per cent, in the houses with the lowest rental ; in other words, over one-third of the cancer deaths occurred among the well-to-do, against less than one-fifth of the deaths from tuberculosis among this class. The data emphasize the practical utility of further statistical research of the relation of housing and economic condi- tions to cancer frequency. 122 CANCER THROUGHOUT THE WORLD frequency, according to organs and parts, and their effect upon the general cancer death rate without such reference to the part of the body affected by mahgnant growth. The specific cancer death rates have been calculated upon an average population for not less than five years, end- ing, unless otherwise stated, with 1910. The mortality from cancer of the stomach, liver and oesophagus and from the skin are given for both sexes combined; but for cancer of the female generative orgaas and of the female breast the rates are based upon the female population only. The relative frequency of cancer of the stomach, liver and oesophagus, combined, for thirteen of the principal countries of the world is shown in the following table, according to which, the highest rate for this form of cancer prevailed in Switzerland, or 70.4 per 100,000 of population, and the lowest in Cuba, or only 12.7. The United States occupies quite a favorable position, with a rate of only 28.3. Comparative Frequency of Cancer of the Stomach, Liver and Oesophagus in Thirteen Countries of the World, 1906-1910 Rate per 100,000 of Population Switzerland 70.4 Uruguay 35.6 Holland 62.2 England and Wales 31.4 Norway 61.4 Ireland 31.0 Bavaria 59.4 United States Registration Area 28.3 Japan* 40.0 Australian Commonwealthf 27.4 Scotlan d 36.0 Italy 26.2 ♦1909-1910. Cubaf 12.7 tl908-1912. The international contrast presented by this table is one of unusual interest. Cancer of the stomach, liver and oesophagus, combined, causes from 30 to 60 per cent, of the mortality due to cancer of all organs and parts. If the theory is sound that erroneous diagnosis primarily deter- mines a low cancer death rate, then it would seem that considering cancer of the stomach and adjacent organs or parts strictly within the inaccessi- ble group, diagnosis must be erroneous to a large extent in countries which have otherwise a high and well-deserved reputation for medical and surgical skill. It is shown, for illustration, by the preceding table that the relative mortality from cancer of the stomach, Hver and oesophagus was higher in Uruguay and Japan than in the United States Registration Area and England and Wales! Furthermore, it is brought out that the rate for this group of cancers was more than twice as high in Switzer- land, Holland, Norway and Bavaria as in the United States Registration Area ! It would certainly seem to be going too far to maintain that the practice of medicine or the development of diagnostic skill or the accuracy of death certification is so considerably superior in Uruguay, Japan, Bavaria, Norway, Holland and Switzerland as to account for the wide disparity between the recorded mortality from cancer of the stomach and adjacent parts in these countries and the United States, Australia and Italy. An equally interesting though less striking comparison is presented in the next table, for cancer of the skin. This comparison is limited to eleven countries, since the returns could not be obtained for Norway and Italy. 123 THE MORTALITY FROM CANCER Comparative Frequency of Cancer of the Skin in Eleven Countries of the World, 1906-1910 Rate per 100,000 of Population United States Registration Area 2.7 Switzerland 1.9 Ireland 2.7 Scotland 1.7 Australian Commonwealth* 2.3 Holland 1.4 England and Wales 2.1 Uruguay 1.1 Cuba* 2.0 Bavaria 0.8 *1908-1912. tl909-1910- Japanf 0.7 The highest recorded mortahty from cancer of the skin, 2.7 per 100,000 of population, is for the United States Registration Area and Ireland, followed by a rate of 2.3 for the Australian Commonwealth, 2.1 for England and Wales, 2.0 for Cuba and 1.9 for Switzerland. The lowest rate for this form of cancer, 0.7, prevailed in Japan; the rate in Bavaria, was 0.8, and in Uruguay, 1.1. When the argument in regard to erroneous diagnosis as measured by a low recorded cancer death rate is applied to cancer of the skin, it would appear that Scotland, Switzerland and Japan occupy a distinctly unfavorable position as regards accessible cancer, but a decidedly favorable one as regards the apparent efficiency in the diagnosis of the inaccessible forms of cancer of the stomach, liver and oesophagus. Such a conclusion requires only to be stated to emphasize its inherent improbability. The same method of reasoning can be successfully applied to the two forms of cancer most common to women, that is, cancer of the generative organs and of the breast. The former is largely internal or inaccessible, whereas the latter is among the most conveniently accessible and easily diagnosed forms of malignant disease. The comparative frequency of cancer of the female generative organs for thirteen of the principal countries is shown in the following table: Comparative Frequency of Cancer of the Female Generative Organs in Thirteen Countries of the World, 1906-1910 Rate per 100,000 of Female Population England and Wales 24.2 Cubaf 18.9 United States Registration Area 22.1 Italy 16.0 Bavaria 21.6 Australian Commonwealthf 15.5 Switzerland 21.4 Holland 13.2 Japan* 20.9 Ireland 12.8 Scotlan d 20.6 Uruguay 12.2 *1909-1910. ti908-i9i2. Norway 1 1 .5 The highest rate for cancer of the female generative organs in the group of countries represented in the table is shown to prevail in Eng- land and Wales, or 24.2, followed by the United States Registration Area with a rate of 22.1, and Bavaria with 21.6. The lowest rates are shown to prevail in Norway, 11.5, Uruguay, 12.2, and Ireland, 12.8. In the comparative table for cancer of the stomach, liver and oesophagus, the Norwegian rate was the third highest, whereas in the present comparison the rate for Norway is the lowest of the thirteen countries repre- sented. If, therefore, the argument were sound that a low cancer death rate must be considered evidence of imperfect diagnostic skill or defec- tive methods of death registration, Norway would rank first in regard to the diagnosis of cancer of the stomach, liver and oesophagus, and last in 124 CANCER THROUGHOUT THE WORLD regard to the diagnosis of cancer of the female generative organs. The same conclusion would apply to Holland. It would further follow that since the rate for Scotland was 20.6 and for Japan 20.9, the diagnosis of cancer of the female generative organs was about equally well devel- oped in these two countries; but as subsequently shown, this con- clusion would not hold at all for the much more easily diagnosed form of cancer of the female breast. The comparative frequency rates for cancer of the female breast for thirteen representative countries of the world are given in the table following: Comparative Frequency of Cancer of the Female Breast in Thirteen Countries of the World, 1906-1910 Rate per 100,000 of Female Population England and Wales 17.9 Holland 9.6 Scotland 15.4 Bavaria 9.1 Ireland 14.0 Norway 7.3 Switzerland 13.6 Italy 5.8 United States Registration Area 13.3 Cuba* 4.5 Australian Commonwealth* 10.6 Uruguay 3.7 *1908-1912. ti909-19l0. Japanf 1.8 The highest frequency rate for cancer of the female breast of the thirteen countries included in the comparison prevailed in England and Wales, the rate being 17.9. The next highest rate, 15.4, prevailed in Scotland, followed by a rate of 14.0 for Ireland, of 13.6 for Switzerland and of 13.3 for the United States Registration Area. The lowest rate prevailed in Japan, being only 1.8, followed by 3.7 for Uruguay, 4.5 for Cuba, 5.8 for Italy and 7.3 for Norway. The rate for Italy of 5.8 is less than one-half the rate of 13.3 for the United States Registration Area. For cancer of the female generative organs the rates are not far apart for England and Japan, whereas for cancer of the female breast the English rate is nearly ten times the recorded rate for Japan* It thus appears that the two forms of cancer diagnosed with difficulty, on account of inaccessibility, that is, cancer of the stomach, liver and oesophagus and cancer of the female generative organs, are diagnosed as well, or even better, in Japan as in England and Wales, whereas the two most accessible forms of cancer, i. e., cancer of the skin and of the female breast, are apparently diagnosed with a much lesser degree of accuracy in Japan than in England and Wales. This conclusion requires only to be stated to bring out its inherent improbability, and yet, by inference, the same argument applies to the broad generalizations in regard to the crude cancer death rate without reference to organs or parts, which for the present purpose, however, has been subjected to further analysis, to establish the fundamental truth that the local variations in cancer frequency throughout the world are primarily conditioned by local causes and not by faulty methods of diagnosis or defective methods of death registration. The statistical data upon which these conclusions are based are given in_ Table 4, Appendix E, which will facilitate the further study of this important phase of the cancer problem. *During a visit to Hawaii I made careful inquiry among practically all the leading physicians regarding the occurrence of cancer of the breast among Japanese women, and the answer was invariably to the same effect, that this form of malignant disease was extremely rare among them. The number of Japanese women ages 25 and over in Hawaii in 1910 was 11,802. Out of 33 deaths from cancer among the Japanese of both sexes during the two years ending June 30, 1913. not a single death was from cancer of the breast. 125 CHAPTER VII THE STATISTICAL DATA OF CANCER FREQUENCY IN AMERICAN STATES AND CITIES Limitations of Crude Statistics — Progressive Increase in the Cancer Death Rate — Mor- tality in Large American Cities — Sources of Errors — Range in Cancer Death Rates — Comparative Mortality Rates by Organs and Parts — Comparative Mortality Rates by Age, Sex and Race — Cancer among Mexicans. The geographical distribution of cancer throughout the United States by separate states and cities is presented in 185 tables. All of these have been derived from official sources, and as far as practicable they have been made to include the essential details of sex, race and organs and parts of the body affected. For many states and cities this in- formation in detail is not available, but sufficient data have been brought together to establish the salient statistical facts of the cancer mortality problem in the United States at the present time. As a rule, the statistics have not been carried further back than 1871, since for most of the cities the data are available only for comparatively recent periods. The statistics by states are limited to the New England States, New York and New Jersey, and a table is included presenting the combined mor- tality for this group of states since 1886 (Table 21, Appendix F, Part 2). For Massachusetts, however, the returns are given since 1856, so as to facilitate the historical study of the cancer problem by means of data which are generally accepted as approximately correct for the earlier period. The statistics for forty-one American cities are sufficient to emphasize the great practical importance of cancer as an urban mortality problem. For certain cities the available information is naturally much more complete than for others ; but it would have unduly enlarged this work and the necessary discussion if all the available facts of cancer mortality, by organs and parts as well as by age, sex and race, had been given in full for the large number of American cities which in 1910 had a population of 30,000 or more. The information omitted would have been largely cumulative evidence, and though useful for local purposes of cancer research, it would obviously be a practical impossibility to include in a work of this kind the entire statistical material of cancer mortality, not only of the United States and its subdivisions, but also of all the other countries of the world. It would have been even more difficult, if not impossible, to briefly and accurately summarize and discuss the large amount of statistical material presented in tabular form for pur- poses of convenient reference and further study and research. Limitations of Crude Statistics There are also many practical limitations which affect the correct interpretation of crude local cancer death rates. All such data, unless standardized for age and sex, require to be used with caution in efforts to illustrate the comparative frequency or infrequency of cancer in the differ- ent sections or cities of the United States. Occasionally large institutions, 126 AMERICAN CANCER STATISTICS such as hospitals, almshouses, asyhims for the insane, soldiers' homes, etc., substantially increase the local cancer death rate, which in such cases requires to be standardized, at least for age, if misleading conclu- sions are to be avoided. When due allowance, however, is made for all the factors which affect the practical utility and accuracy of cancer mor- tality statistics, there remains no question of reasonable doubt that on the whole the available data are fairly comparable and that they are an approximately accurate indication of local variations in cancer frequency. Progressive Increase in the Cancer Death Rate Considering, first, the combined cancer mortality statistics of the New England States and New York and New Jersey since 1886, the data are set forth with the required brevity in the following table, by quinquen- nial periods down to 1910 and thereafter by single years. Mortality from Cancer in the New England States, New York and New Jersey, 1886-1913 Deaths Rate per Relative Rate Years Population from 100,000 1886-1890 Cancer Population Being 100 1886-90 55,320,449 26,215 47.4 100.0 1891-95 64,879,439 34,536 53.2 112.2 1896-00 71,405,669 44,645 62.5 131.9 1901-05 78,132,762 55,501 71.0 149.8 1906-10 87,343,060 69,140 79.2 167.1 1911 18,699,051 15,980 85.5 180.4 1912 18,976,968 16,640 87.7 185.0 1913 19,327,238 17,385 90.0 189.9 The progressive increase in the cancer death rate of a large and con- tiguous area in the United States is concisely shown by this table. The details by single years are given in Table 21, Appendix F, Part 2. The average cancer death rate of this area, which in 1913 contained a population of more than 19,000,000, has increased from 47.4 during the five years ending with 1890 to 79.2 during 1906-10 and to 90.0 during the year 1913. A similar upward tendency of the cancer death rate is disclosed by the combined experience of twenty large American cities since 1881, which in 1913 had a population of 13,400,000. A sum- mary of the data is given in the table below : Mortality from Cancer in Twenty Large American Cities, 1881-1913 Deaths Rate per Relative Rate Years Population from 100,000 1886-1890 Cancer Population Being 100 1881-85 30,328,347 14,735 48.6 95.9 1886-90 35,302,944 17,884 50.7 100.0 1891-95 40,912,510 22,513 55.0 108.5 1896-00 47,016,267 28,533 60.7 119.7 1901-05 53,386,935 37,127 69.5 137.1 1906-10 60,116,913 47,701 79.3 156.4 1911 12,849,687 10,713 83.4 164.5 1912 13,125,121 11,203 85.4 168.4 1913 13,400,553 11,971 89.3 176.1 127 THE MORTALITY FROM CANCER According to this table and the details by single years, as given in Table 22, Appendix F, Part 2, the cancer death rate of twenty large American cities increased from an average rate of 50.7 during the five years ending with 1890 to 79.3 during the five years 1906-10 and, fur- ther still, to 85.4 during the year 1912 and to 89.3 during the year 1913. Cancer Mortality of Southern Cities In Southern cities the cancer death rate of the white population in- creased from an average of 52.7 during the period 1891-95 to 96.6 in 1913. The corresponding increase in the negro cancer death rate during this period was from 39.1 to 73.5. The relative increase in the rate for the white population of Southern cities was 83.3 per cent., in comparison with an increase of 88.0 per cent, for the negro population.* Mortality of Large American Cities In the table following, the principal American cities for which the infor- mation is available are arranged in the order of their recorded cancer mor- tality frequency for the five-year period ending with 1910. The details for these cities are given in Appendix F, Part 2, and it is only necessary to call special attention to the fact that, on account of their local importance, the two subdivisions of the combined Boroughs of Manhattan and Bronx and of Brooklyn have been included, in addition to the rate for Greater New York. Cancer Mortality Rates of American Cities, 1906-1910 Rates per 100,000 of Population City Average Rate City Average Rate San Francisco 102.5 Boston 99.4 Providence 96.9 Los Angeles 94.9 Cincinnati 93.0 Hartford 91.9 New Haven 89.8 Dayton 88.5 Rochester 88.2 Springfield (Mass.) 86.9 District of Columbia 86.0 Baltimore 85.8 Omaha 85.7 Buffalo 84.0 New Orleans 82.2 Philadelphia 81.9 Hoboken 80.7 Columbus 79.5 Boro, of Manh. and Bronx . . 78.4 St. Louis 78.4 Denver 77.9 Newark 76.9 Chicago 76.5 Greater New York 74.1 Richmond 73.9 Kansas City (Mo.) 71.1 St. Paul 71.1 Indianapolis 70.4 Boro. of Brooklyn 68.9 Milwaukee 68.4 Nashville 68.0 Pittsburgh 66.4 Minneapolis 65.3 Detroit 64.5 Cleveland 62.9 Louisville 61.1 Jersey City 60.5 Charleston 53.6 Seattle 50.2 Augusta (Ga.) 49.1 Memphis 48.7 Savannah 47.1 *The ethnological aspectsof the cancer problem, with special reference to the American negro, are briefly dis- cussed in the third volume of the cancer treatise by J. Wolff. The data used, however, are inadequate to the pur- pose. The same conclusion applies to the brief references to the negro cancer death rate in the recent work on the cancer problem by Dr. Seaman Bainbridge. For some exceedingly interesting obser\THions on cancer frequency among the negro population, see article by Dr. Rudolph Matas in the "System of Surgery," by Dr. Frederick S. Dennis. Also "Observations on tumor formation in white and colored races compared," by Rudolph Matas, M.D., in "The Surgical Peculiarities of the American Negro," Transactions of the American Surgical .Association, 1896. 128 AMERICAN CANCER STATISTICS Sources of Statistical Errors It has not been feasible to standardize these rates for variations in the age and sex distribution of the populations. The liability to error in this respect is less serious than the local increase in cancer death rates result- ing from admissions to hospitals of cancer patients from surrounding and even remote localities.* It is unfortunate that at the present time such deaths are not redistributed in the final tabulations of mortality according to the residence of the deceased. Such a correction is par- ticularly called for in the case of cities which provide exceptional in- stitutional facilities for the treatment of malignant disease. It, how- ever, is a reasonably safe assumption that this factor of error is not of as much importance as is often assumed to be the case.f In a strictly scientific study of the local incidence of cancer a redistribution of the deaths according to the residence of the deceased is, of course, required. The present state of our American vital statistics, however, does not afford the means for such a redistribution in the general mortality re- turns, and they have, therefore, to be accepted as published, subject to the foregoing words of caution, which apply to practically the entire statistical material presented in this work. A striking fact disclosed by the preceding table of cancer mortality rates of American cities is the wide range between the maximum of 102.5 for San Francisco and the minimum of 47.1 for Savannah. The rates are necessarily affected by the age and sex distribution of the population, but for general purposes they are useful in providing an approximate index of local cancer frequency. Where the female population is decidedly in excess of the male population, it is obvious that the crude death rate, unless standardized for sex, would be misleading, since as a rule the cancer death rate of males is considerably below the cancer death rate of females. In Boston, for illustration, the male cancer death rate is 75.2, whereas the cancer death rate of females is 126.5 (Tables 35 and 36, Appendix F, Part 2). The same conclusion applies to the element of race, which in part accounts for the relatively low cancer rates of certain Southern cities. For Charleston, S. C, for illustration, the cancer death rate of the white population is 73.2, whereas for the colored popu- lation the rate is only 36.6 (Tables 44 to 46, Appendix F, Part 2). The crude death rate for both races combined is therefore reduced by the large proportion of negro population, and the rates are required to be considered separately for the two races, if erroneous conclusions are to be avoided. It is hardly necessary to point out in this connection that the mortality returns for the negro population are intrinsically less trustworthy than those for the white population, in view of the relatively low professional status of the negro physicians and the comparatively high proportion of deaths among the negro population without proper medical attendance. Comparative Cancer Mortality by Organs and Parts of the Body As an illustration of the most convenient method available in the *This conclusion applies with special force to the city of Boston, where the Massachusetts General Hospital tends to increase the local cancer death rate by the admission of cancer patients not only from the immedi- ately surrounding territory, but even from other New England States and still more distant parts of the country. tSee remarks, on page 144, on Cancer Frequency according to Size of Cities. 129 THE MORTALITY FROM CANCER comparative study of cancer frequency by organs and parts and according to sex, the following two summary tables are inserted, for the city of Boston for the period of 1903-12 and the city of San Francisco for the period 1906-13. Mortality from Cancer in Boston, Mass., by Organs and Parts according to Sex, 1903-1912 TOTAL Organ or Part Deaths Buccal cavity 308 Stomach and liver 2,027 Peritoneum,intestines and rectum 1,127 Female generative organs 921 Breast 657 Skin 82 Other or not specified organs 1,318 Rate per 100,000 Population 4.9 31.9 17.7 14.5 10.3 1.3 20.7 All organs 6,440 101.3 MALES Rate per Deaths 100,000 Population 248 8.0 918 29.5 446 14.3 7 44 0.2 1.4 679 21.8 2,342 75.2 FEMALES Rate per Deaths 100,000 Population 60 1.9 1,109 34.2 681 921 650 38 639 21.0 28.4 20.1 1.2 19.7 4,098 126.5 Mortality from Cancer in San Francisco, Cal., by Organs and Parts according to Sex, July 1, 1906, to June 30, 1913 TOTAL Organ or Part Deaths Buccal cavity 186 Stomach and liver 1,377 Peritoneunijintestines and rectum 442 Female generative organs. 406 Breast 253 Skin .. 67 Other or not specified organs 468 Rate per 100,000 Population 6.5 48.0 15.4 14.2 8.8 2.3 16.4 Morgans 3,199 111.6 MALES Rate per Deaths 100,000 Population 172 10.6 878 54.1 223 13.7 1 o'.i 41 2.5 336 20.8 1,651 101.8 FEMALES Rate per Deaths 100,000 Population 14 1.1 499 40.1 219 406 252 26 132 17.6 32.6 20.2 2.1 10.6 1,548 124.3 Inadequacy of Existing Data It is regrettable that information regarding the local cancer problem should not be available in this form for all of the cities considered. Obviously the local study of cancer in its final analysis reduces itself to the separate consideration of cancer frequency, by organs and parts, according to sex, race and age. Such an extended statistical analysis, however, results in extremely complex problems of the precise correlation of the statistical conclusions to the medical, anthropological, environmental and even sociological considerations which affect the cancer problem. It will probably not be found feasible to provide much more than a complete statistical analysis of the cancer mortality 130 AMERICAN CANCER STATISTICS of the larger states and cities and of course for the registration area of the United States as a whole.* The admirable consideration of the statistical details of the cancer problem, with special reference to the requirements of modern cancer research, in the Annual Reports of the Registrar-General for England and Wales may be referred to as sugges- tive of the method most likely to produce results of practical utility. In view of the enormous extent to which minute pathological re- searches have been carried in the more or less illusive hope of ascertain- ing a cancer cause and a cancer cure, it would seem but reasonable to insist upon more extended but thoroughly qualified statistical research than has heretofore been the case and the gradual replacement of crude and even misleading data with returns of unquestioned accuracy and con- clusiveness made available for critical and minute analysis. Comparative Cancer Mortality Rates by Age, Sex and Race No aspect of the cancer problem from the statistical point of view has been more neglected than the age factor, which is fundamental in every statistical discussion of the cancer mortality problem. Only a few American cities provide the necessary information of cancer mortal- ity by age and sex, and only a very few furnish the absolutely essential additional information of cancer mortality by age, sex and organs and parts. The table followingf is suggestive of the practical value of statistical analysis of cancer by age, sex and race; but in Appendix F, Part 2, numerous tables are included which further illustrate the age incidence of cancer by organs and parts: Mortality from Cancer in the District of Columbia, U. S. A., 1901-1910 by Age, Sex and Race, Rate per 100,000 of Population WHITE COLORED Ages Males Females Males Females Under 10 1.7 0.6 1.7 •• 2.7 10-19 4.2 1.1 20-29 5.8 3.1 9.7 13.1 SO-39 23.2 56.0 26.3 72.3 40-49 62.5 162.2 48.7 207.3 50-59 182.4 347.3 139.6 328.9 60-69 413.7 456.4 310.1 386.6 70 and over 610.6 556.9 335.1 522.1 All ages 70.6 104.8 38.6 86.5 40 and over 217.1 312.0 130.2 293.9 The value of specialized cancer research has been well brought out by Bashford in his observations on the differential age incidence of sarcoma and carcinoma. | The variations in cancer incidence by age, sex *Such an analysis of cancer mortality in detail is contemplated by the Division of Vital Statistics of the United States Census for the year 1914. The same is to be published as a monograph apart from the annual report on the mortality of the registration area as a whole. fFor a more extended discussion of the cancer statistics of the District of Columbia, see my "Menace of Cancer" published in the Transactions of the American Gynecological Society, 1913. (See also Tables 182 to 136, Appendix F, Part 2.) t The age incidence by single years of life in sarcoma and carcinoma is given in detail in the Prudential Indus- trial Mortality Experience data appended to the chapter on Cancer as a Problem in Life Insurance Msdicine, Tables 8 to 15, Appendix D. 131 THE MORTALITY FROM CANCER and race, with particular reference to organs and parts, are so numerous, so perplexing and so frequently conditioned by special circumstances that extreme caution is invariably necessary in utilizing the data for practi- cal purposes. At the same time, it would seem that special research in this direction gives promise of revealing much that is new in the scientific study of the cancer problem; for there can be no serious question of doubt that the variations in frequency are real and not apparent, are more often the result of local conditioning circumstances than of errors in statistical tabulation and analysis or a matter of pure chance. For illustration, almost every table by organs and parts exhibits a dis- tinctly higher mortality of cancer of the buccal cavity among males than among females and as a rule a higher mortality from cancer of the peri- toneum, intestines and rectum among women. Without exception the general cancer mortality in the United States is higher for the white population than for the negro, regardless of latitude and longitude, and the fact that as a broad principle the two races are living under much the same conditions, with a constant approach towards equality in all that ministers to the needs of the body, somehow or in some way affects nutrition and metabolism, in brief, development and growth.* Cancer among Mexicans The mortality from cancer among Mexicans in the United States has not been made the subject of an extended investigation. It has seemed, however, advisable for the present purpose to make an original analysis of the mortality returns for San Diego and Los Angeles, Cali- fornia, and El Paso and San Antonio, Texas, for the period 1910-14. Out of 2,935 deaths of Mexican males, ages 15 and over, 91, or 3.1 per cent., died from cancer. The corresponding proportion of deaths from cancer among 2,419 Mexican females was 144, or 6.0 per cent. At ages 15-44 the proportionate mortality from cancer was 1.6 per cent, for males and 3.7 per cent, for females; and at ages 45 and over, 5.1 per cent, for males and 9.1 per cent, for females. The proportionate mor- tality is higher than expected, considering the rather simple mode of life and the peculiar diet of this class of people. The Mexican element of the southwest is chiefly of the peon class with a fair degree of inter- mixture with the Indians of Northern Mexico. For the City of Mexico the average cancer death rate is 53.1, which compares with a rate of 74.1 per 100,000 for the city of New York. *In this connection the following observations and conclusions by Dr. Rudolph Matas, in his treatise on "The Surgical Peculiarities of the American Negro," are of special interest and practical importance. Dr. Matas concludes: "1. That the tendency to the formation of neoplastic tissue whether purely hyperplastic or heteroplastic is greater in the negro than in the white race. 2. That the typical mesoblastic derivatives of the adult connective tissue group are especially prone to develop in the negro. 3. That of this group, the fibroma and cicatricial keloid preponderate sufficiently to give to the black race a striking pathological peculiarity. 4. That the mesoblastic derivatives of the embryonal connective tissue type, i. e., the sarcomata, are also apparently more frequent in the negro with the sole exception of the melanotic sarcomas, which are rare. 6. That contrary to the generally accepted belief, the epiblastic derivatives of embryonal type, or the true cancers, appear, statistically at least, to be even more common than in the white race. 6. That in regard to the malignant neoplasms the negro constitution has probably undergone some change under the conditions of American civilization, since it cannot be doubted that cancer is comparatively rare in the native African, rare also in the original slave population in this country, and has only become a common disease in the American negro of the last few generations. It is also probable that the conditions that are causing an increase in the prevalence of cancer among the whites are also acting with the same effect upon the negroes." See also the consolidated statistics of cancer in the experience of the Charity Hospital of New Orleans, by race and organs and parts, for the period 1908-12, Tables 104 and 105, Appendix F, Part 2. 132 CHAPTER VIII THE STATISTICAL DATA OF CANCER FREQUENCY IN FOREIGN COUNTRIES Comparative Cancer Mortality Rates for Europe — Africa — Asia — Australasia — Western Hemisphere — Limitations of International Statistics — Cancer a World-wide Menace — Effect of Latitude and Longitude, and of Size of Cities — Comparative Death Rates of American and European Cities. The cancer statistics available for foreign countries are of much the same character and extent as those available for the registration area of the United States. Some of the returns are unquestionably much more trustworthy than others, but their intrinsic worth can be determined only by precise and laborious methods of statistical analysis and medi- cal reconsideration of the original death certificates. Most of the original sources of cancer mortality statistics for foreign states and cities are quite difficult of access to American students of the statistical aspects of the cancer problem, and it has therefore seemed advisable to give special consideration to the statistics of foreign countries and as far as practicable to those of every important geographical subdivision of the world, so as to make the presentation of the facts meet all reason- able requirements. Much available information has necessarily been excluded, since such data would rather have been in the nature of cumu- lative evidence, not absolutely essential to the present purpose, however useful the facts would have been in connection with strictly local cancer mortality studies. Comparative Cancer Mortality Rates for Europe The foreign statistics are given in Appendix G, and contained in 224 tables for the Continent of Europe and 163 tables for non-European countries other than the United States of America. In addition there are given in Appendix E 4 tables which show the cancer mortality according to latitude and size of cities and by organs and parts in thirteen principal countries of the world. Unless specifically so stated all the information from which these tables have been compiled has been derived from official sources, which are, as a rule, indicated in a footnote to each table. A full discussion of this vast amount of statis- tical evidence regarding cancer frequency throughout the world would obviously be an impossible task in a work of this kind. The main pur- pose of the present investigation, as elsewhere stated, has been and is to make a reasonably large amount of statistical information regarding the cancer problem available for further study and research. The assembled evidence of cancer mortality throughout the world reemphasizes the earlier conclusion that the disease is gradually on the increase in practically all civilized countries. For certain European countries the increase by quinquennial periods during the fifteen years ending with 1910 is briefly shown in the table following; 133 THE MORTALITY FROM CANCER Comparative Mortality from Cancer in European Countries, 1896-1910 1896-1900 1901-1905 1906-1910 Rate per Rate per Rate per 100,000 100,000 100,000 Population Population Population England and Wales 80.1 86.7 94.0 Scotland 77.1 84.8 99.7 Ireland 58.1 68.5 78.8 Norway 85.7 94.9 96.6 Denmark (cities) 118.9 129.1 137.3 German Empire 70.8 77.7 84.2 Holland 91.9 97.8 103.5 Switzerland 127.4 128.3 125.9 Austria 68.9 74.7 78.3 Hungary 30.7 39.1 43.6 Italy 50.9 55.2 63.6 France (cities) 97.3 92.1 102.7 Combined average 69.1 74.2 81.0 This table brings out the striking fact that for all European countries, with the exception of Switzerland, decidedly higher cancer death rates prevailed during the five years ending with 1910 than during the quin- quennial period ending with 1900. For all of the countries combined the cancer death rate has increased from 69.1 per 100,000 of population during the first five years to 74.2 during the second and to 81.0 during the third. The cancer death rate of Switzerland has attained to so extremely high a proportion that a maximum point of frequency has probably been reached.* Of course, in the case of small communities much higher death rates may be and are frequently experienced, and this is also true for certain cities; but for large countries as a whole it would probably be safe to assume a maximum attainable average cancer mortality rate of not less than 130 per 100,000 of population. For the principal European countries the average cancer death rates for recent years are briefly summarized below : EUROPEf rp . , Deaths Rate per „ ^'^*^f from 100,000 Population (.^^^pj. Population Austria 141,462,903 113,221 80.0 Belgium 36,936,410 24,712 66.9 Channel Islands (Guernsey)... 208,900 227 108.7 Denmark (cities) 5,453,322 7,747 142.1 England and Wales 178,980,717 174,602 97.6 France 196,878,000 148,662 75.5 German Empire 318,876,524 277,710 87.1 *The high cancer death rate of Switzerland is not the result of an excess in the proportion of popula- tion ages 45 and over. According to the most recent census returns, this proportion was 2^2.61 per cent, for Switzerland, 22.85 per cent, for Denmark, 21.36 per cent, for England and Wales, and 18.89 per cent, for the United Slates. fThe data used in this table are, as far as practicable, for the period 1908-12. For information in detail see Table 4, Appendix G. 134 FOREIGN CANCER STATISTICS EUROPE— Continued Deaths Rate per Total from 100,000 Population Cancer Population Gibraltar* 97,823 81 82.8 Greece (cities) 2,117,670 1,100 51.9 Holland 29,479,395 31,375 106.4 Hungary 104,006,496 47,374 45.5 Ireland 21,925,004 17,796 81.2 Isle of Man 261,530 339 129.6 Italy 171,995,665 112,087 65.2 Malta 1,056,196 512 48.5 Norway 11,774,100 11,461 97.4 Portugal 29,060,580 6,504 22.4 Roumania (cities) 6,410,450 3,940 61.5 Russia(MoscowandPetrograd) 8,624,796 7,812 90.6 Scotland 23,686,521 24,399 103.0 Serbia 13,876,836 1,669 12.0 Spain 97,705,000 51,135 52.3 Sweden (cities) 6,685,581 7,022 105.0 Switzerland 18,686,442 23,228 124.3 Turkey (Constantinople) 5,750,000 2,001 34.8 Total 1,431,996,861 1,096,716 76.6 Population, 1911 291,384,190 Limitations of European Cancer Data The average cancer death rate for this group of countries was 76.6 per 100,000 of population. This rate is based on a mean population of the countries considered of nearly 300,000,000. The rates are not always for the countries as such, but in some cases only for political subdivisions or large cities. Precise information regarding the details of this tabula- tion will be found in the notes following Table 4 of Appendix G. In further explanation it requires to be pointed out that the high rate for Denmark is partly the result of the fact that the returns are limited to cities and towns, since the data are not made available for the Danish Kingdom as a whole. The high rates for the Isle of Man (129.6) and the Channel Islands (108.7) are suggestive.f The extremely low rate *The following interesting reference to Cancer in Gibraltar is from the Colonial Office Correspondence in connection with the Imperial Cancer Research Scheme (Part I, p. 31) : "The organs chiefly affected by cancer in natives of Gibraltar, and in Spaniards residing in the neighborhood, are, in males, the lips and tongue; in females, the uterus and breast. Probably three-fourths of all cases of cancer met with in the practice of the Colonial Hospital, have their seat in one or the other of these organs. The predisposing causes of cancer, in this part of the world, appear to me to be, in males, excessive tobacco smoking, leading to irritation of the lips and tongue; in females, premature child-bearing and lactation. The Spaniard's cigarette or cigar is never absent from his lips if he can help it, and he allows it to burn so close that the actual fire must frequently char the epithelium of his mouth. Again, in females, the generative organs come to maturity at a relatively early period, as compared with the general development of the frame, and consequently early sexual relations and child-bearing are frequent. This results in undue irritation and injury of the genital tract at a stage when its component tissues are as yet immature, and a condition of cell proliferation is set up which, at some future time, predisposes to cancer formation." fThe proportion of population ages 45 and over in the Isle of Man and in the Isle of Guernsey are rather high, but by no means decidedly excessive. For the Isle of Man, according to the census of 1911, the proportion was 26.9 per cent., and for thg Isle of Guernsey 24.2 per cent. The corresponding proportion for England and Wales was 21.4 per cent. 135 THE MORTALITY FROM CANCER for Serbia (12.0) is, no doubt, in part at least, the result of defective death registration and poor medical attendance. There are, however, in all probability local conditions which make for a low cancer death rate in Serbia, for as shown by the returns for Roumania the cancer death rate for that country was not much below the average for the European continent as a whole. Among the numerous special tables of exceptional interest are the returns for Ireland, by duration of illness, for Norway, by geographical districts, for Bavaria, by geographical divisions, for Munich, by religious confession, for France, by the size of cities, ior Switzerland, by cantons, according to the predominating German, French or Italian population, for ^' ienna, with special reference to the Jewish population, for Hungary, by principal races, and for Italy, by provinces. All these tables sug- gest the practical utility of specialized local statistical cancer studies, which are likely to yield important results. Comparative Cancer Mortality Rates for Africa The available cancer statistics for certain political subdivisions of the Continent of Africa are given in the table following: AFRICA* _^_ rp . 1 Deaths Rate per ■p i , t- from 100,000 Population Cancer Population Algeria (Europeans only) 3,688,433 1,257 34.1 Cape Colony (cities) 1,898,895 1,067 56.2 Mauritius 1,843,819 171 9.3 Natal 1,111,756 366 32.9 Sierra Leone (Freetown) 68,218 9 13.2 Transvaal (Johannesburg) 430,745 148 34.4 Total 9,041,866 3,018 33.4 Population, 1911 1,959,645 The cancer mortality returns for practically all the African countries are of doubtful intrinsic value. Most of the information is of a frag- mentary character, due, naturally, to the exceptional governmental conditions and the proportionately large native population. The com- bined cancer mortality rate for African countries was only 33.4 per 100,000 of population. The exceptionally low rate for Mauritius (9.3) is partly explained by the large East Indian population, and the relatively much higher rate for Algeria (34.1) is due to the fact that the rate is for the European population. There are no cancer statistics for Egypt or even for Cairo and Alexandria that could be utilized in con- nection with the present investigation.! Among the more interesting data in relation to the African continent are the hospital statistics for Mauritius, the returns for Johannesburg, by race, the hospital statistics *The data used in this table are, as far as practicable, for the period 1908-12. For information in detail see Table 217, Appendix G. fThe occurrence of cancer in Egypt has been discussed by W. R. Williams in his "Natural History of Cancer," and also in the third volume of the treatise on cancer by J. Wolff (p. 190). According to F. C. Madden, in a treatise on the "Diseases of the Orient," cancer was ascertained to be extremely rare among the Berbers and Sudanese, who are vegetarians, the cases observed being practically limited to the Arabs and the CopJ^, who have more or less adopted the European mode of life. 136 FOREIGN CANCER STATISTICS for Freetown, which is the capital of Sierra Leone, and the hospital returns for Portuguese Guinea. These returns are merely indicative of sources of information which have thus far been utilized to only a limited extent in the scientific study of the cancer problem. The data collected for the British Colonies through the Imperial Cancer Research Fund have failed to yield the abundant amount of material which an energetic and persistent collective effort on the part of the respective governments and the medical profession could unquestionably bring forth. The local possibilities of specialized cancer research find their best illustration in the discussion of the spread of cancer among the descendants of the liberated Africans or Creoles, by W. Renner, M. D., appended to the annual report of the Medical Department for the Colony of Sierra Leone, for the year ending December 31, 1909. When every reasonable allowance is made for the want of accuracy and com- pleteness in the available returns for the African continent, it would seem safe to assume that cancer is of a relatively very low degree of fre- quency in African countries, even among the white population of Euro- pean origin, and that among the native population, as a general rule, malignant disease is extremely rare. Comparative Cancer Mortality Rates for Asia The available statistics for the Continent of Asia are briefly sum- marized in the next table: ASIA* Total Population Ceylon 20,076,320 Hongkong 1,737,310 India (Calcutta) 4,456,200 Japan 242,460,425 Penang 1,391,089 Philippine Islands (Manila) 1,190,154 Shanghai (Europeans only) 68,684 Singapore 1,434,780 Total 272,814,962 148,447 54.4 Population, 1911 57,820,460 The average cancer death rate for the Continent of Asia, according to this table, is 54.4 per 100,000 of population, as compared with a rate of 33.4 for the Continent of Africa. The rate therefore approaches more closely to the European average of 76.6, and particularly so in the case of Japan, for which country the rate was 60.2. f For certain subdivisions of the Continent of Asia the rates are unusually low, especially for *The data used in this table are, as far as practicable, for the period 1908-12. For information in detail see Table 232, Appendix G. fSome exceedingly interesting observations regarding cancer in Japan have been published in the periodical Gann, in German, under the title "Results of Cancer Research in Japan," for the year 1907. Additional information of a trustworthy character is contained in the special analysis of the causes of death among persons insured with the Meiji Life Insurance Company of Japan. 137 Deaths from Cancer Rate per 100,000 Population 1,133 140 5.Q 8.1 522 11.7 145,965 143 60.2 10.3 325 27.3 38 55.3 181 12.6 THE MORTALITY FROM CANCER Ceylon,* Hongkong,! Calcutta, Penang and Singapore. For Shanghai, hoTvever, the rate for the European population is as high as 55.3, which closely approaches to the average cancer death rate of European coun- tries of about fifteen years ago. That this rate for Shanghai is quite trustworthy is brought out by the fact that the corresponding death rate of Europeans in Manila is 50.6. Among the most interesting returns for the several countries of Asia are those of the city of Calcutta,! which extend over nearly forty years, the hospital data, by organs and parts, for Singapore, the special statistics for the European population of the Dutch East Indies, the returns for the foreign-resident population of Shanghai, the returns, by organs and parts, for Japan § and the cor- responding information for the city of Manila. Comparative Cancer Rates for Australasia For Australasia the cancer statistics, on account of the relatively much larger European population, are naturally of a more satisfactory character. The indigenous population in most of the countries considered is relatively a negligible factor. The general results are summarized in the following table : AUSTRALASIA || Deaths Rate per Total from 100,000 Population Cancer Population Hawaii 962,860 392 40.7 New South Wales 8,142,200 5,948 73.1 New Zealand 4,963,912 3,731 75.2 Northern Territory 6,678 3 44.9 Queensland 2,961,089 1,870 63.2 South Australia 1,996,995 1,525 76.4 Tasmania ; 950,717 621 65.3 Victoria 6,521,936 5,441 83.4 Western Austraha 1,380,353 814 59.0 Total 27,886,740 20,345 73.0 Population, 1911 5,703,425 *Malignant disease, according to the Colonial Office Correspondence in the furtherance of the Imperial Cancer Research Scheme (Part I, p. 63) is comparatively rare in Ceylon, the average age at death being about forty years. The principalform of the disease is cancer of the buccal cavity, which is attributed to the chewing of betel. This is described as consisting of " tobacco, betelleaves,areca nut, and alittle slakedlime to promote the flow of the saliva." It is stated that every native chews betel and eats curry flavored with hot chilies, so that there are invariably two irritants present in the mouth, either of which may determine the occurrence of malig- nant new growth. Cancer of the breast is rare, though native women suckle their children a long time. fAccording to the Colonial Office Correspondence in the furtherance of the Imperial Cancer Research Scheme (Part II, p. 16), the post-mortem records of Hongkong show that out of 15,365 Chinese, only ten were found to have died of malignant disease. The following extract is also from the Correspondence of the Colonial Office in connection with the Imperial Cancer Research Scheme (Part II, p. 17). Cancer among Chinese in Hongkong. "In the case of a disease in which the mean annual death-rate is only 4.45 per 100,000, personal idiosjTicrasies are of more moment than the habits of the community, but of these former I have no information. As, however, the habits of the community may throw some light on the fact that the Chinese in Hongkong enjoy a marked immunity from maligoant disease, I may say that they smoke but little in com- parison with the European, they practically do not chew at all, and their diet consists in the main of rice, with small quantities of fish or pork, and that spices, peppers and hot chilies are not used by them to any appreciable extent. The Chinese 'soy,' or sauce, of which very little is used at a time, is a verj' mild aromatic liquid, ha\-ing a slightly vinegary taste. In the case of the Chinese in Hongkong it is principally the alimen- tary canal and the abdominal viscera that are affected." tOf special interest in this connection are the researches of Rogers of Calcutta, including a study of one 138 FOREIGN CANCER STATISTICS The average cancer death rate for Australasia was 73.0, which ap- proaches quite near to the average European rate of 76.6. The rate was highest in the State of Victoria, 83.4, and lowest in Hawaii, 40.7. The cancer death rate of Hawaii, which for present purposes has been in- cluded within the geographical limits of Australasia, is naturally affected by the preponderating Asiatic elements. Among the interesting tables for Australasia is a summary return for the Commonwealth of Australia by organs and parts, with distinction of sex, as given in an abbreviated form below: Mortality from Cancer in the Commonwealth of Australia, by Organs and Parts, according to Sex, 1908-1912 Rate per 100,000 of Population MALES FEMALES Buccal cavity 11.5 1.2 Stomach and liver 31.8 22.6 Peritoneum, intestines, rectum 8.2 9.0 Breast 10.6 Female generative organs 15.5 Skin 3.0 1.5 Other organs 19,2 12.2 Total 73.8 72^6 The rates for Australia may be considered as comparable with the corresponding cancer statistics for the United States and Europe. For Fiji the hospital statistics have been included, on account of the special interest which attaches to the returns of cancer occurrence, by organs and parts, according to race. It is regrettable that there should not be more conclusive information available in detail for Hawaii. Comparative Cancer Mortality Rates for the Western Hemisphere For the American Continent and other parts of the Western Hemis- phere the returns have been summarized in the table following, which represents a registration area with approximately 83,000,000 population. For most of the countries considered the returns are limited to the large cities, and complete returns are not even available for the entire United States. The average rate for the Western Hemisphere, as determined by this tabulation is 65.7, but the range in the rate is quite considerable, and some exceptionally high rates reported for certain localities require further consideration to establish their accuracy. In the summary table the average rate for the registration area of the United States has been included, to facilitate convenient comparison; but the statis- tical details for this section are given separately in Appendix F, Part 1, following the more extended discussion of the cancer mortality of this country. thousand autopsy records, the results of which were made public in the India Medical Gazette. The evidence tends to show that cancer was comparatively rare among the natives of India. ^According to K. Sato, as quoted by Coley, of 64,030 patients treated in Japanese hospitals, only 2.14 per cent, suffered from cancer. The proportions in which the various organs were affected were uterus, 33.5 per cent., stomach, 32.0 per cent., intestines, 6.2 per cent., breast, 6.7 per cent., skin, 2.0 per cent., oesophagus, 1.5 per cent. IIThe data used in this table are, as far as practicable, for the period 1908-12. For information in detail see Table 259, Appendix G. 139 THE MORTALITY FROM CANCER AMERICA* Western Hemisphere Deaths Rate per Total from 100,000 Population Cancer Population Argentina* 17,807,056 11,392 64.0 Bermuda 92,780 52 56.0 Bolivia (La Paz) 316,090 69 21.8 Brazil (cities) 9,384,279 3,145 33.5 British Guiana 1,487,922 271 18.2 British Honduras 197,820 29 14.7 British West Indies* 6,897,104 1,439 20.9 Canada* 19,689,825 12,208 62.0 Chile 17,047,786 6,077 35.6 Colombia (Bogota) 242,986 218 89.7 Costa Rica 1,849,534 751 40.6 Cuba 10,892,077 4,855 44.6 Danish W.Ind. (Is. of St.Thomas) 53,393 63 118.0 Dutch Guiana (Paramaribo) .... 174,775 167 95.6 Ecuador (Guayaquil) 200,000 122 61.0 Mexico (City of Mexico) 2,355,330 1,165 49.5 Newfoundland 1,192,843 616 51.6 Nicaragua 2,180,000 231 10.6 Peru (Lima) 170,000 202 118.8 Salvador (San Salvador) 357,240 208 58.2 United States (Reg. Area) 271,207,437 202,621 74.7 Uruguay 5,421,854 3,577 66.0 Venezuela 13,331,180 1,960 14.7 Total 382,549,311 251,438 65.7 Population, 1911 82,835,662 For most of the islands of the West Indies the rates are exceptionally low, a condition readily explained by the preponderating negro popu- lation. The relatively high rates for Bermuda (56.0) and the Danish West Indies (118.0) are, no doubt, explained by the high proportion of white population and special hospital facilities made use of by others than residents of the immediate locality. The low rate for Venezuela is probably, in part at least, the result of defective registration and poor medical facilities in the interior. The relatively low rate for Trinidad is partly explained by the high proportion of East Indians in the Trinidad population. There is at present no explanation for the rather excessive rates of cancer frequency returned for the large cities of the United States of Colombiaf and Peru. The rates for these countries, being limited to the capital cities, are probably increased by hospital accommodation for operative treatment. *The data used in this table are, as far as practicable, for the period 1908-12. For information in detail see Table 29(), Appendix G. fA curious error occurs in the statistical survey of cancer throughout the world in the third volume of J. Wolff's treatise on cancer, iu which the District of Columbia of the United States is confused with the United States of Colombia, and given accordingly in the discussion of cancer in South America. (Lehre von dcr Krebskrankheit, Vol. iii, p. 25.) 140 FOREIGN CANCER STATISTICS Among the more interesting tables for the Western Hemisphere are the cancer statistics for Cuba, by organs and parts, according to sex and race, the statistics for the city of Mexico, by organs and parts; and the corresponding returns for the city of San Salvador, limited to a single year, the returns for the city of Lima, Peru, by organs and parts, with distinction of sex, but with rates calculated only for both sexes combined, on account of the want of trustworthy data regarding the sex distribution of the population. The high rate for the city of Trujillo, Peru, is of doubtful accuracy and possibly impaired by the indefinite information regarding the exact population returns. Two tables have been in- cluded for the federal district of Rio de Janeiro, showing the percentage distribution of cancer deaths, by organs and parts and according to sex, and there is a similar table for the city of Bahia, Brazil, and the city of Buenos Aires, Argentina. For the city of Santiago, Chile, a table is in- cluded of the mortality from cancer, by organs and parts, but without reference to sex. There is a similar table for the Republic of Uruguay, and separately for the city of Montevideo. Inherent Limitations of International Cancer Data For many of the countries considered the returns are unquestionably of doubtful value, and strong reasons exist why, perhaps, some of the returns should have been excluded on account of their apparent intrinsic untrustworthiness. Since, however, the primary purpose of this work is to encourage research into the statistical intricacies of the can- cer problem, it has seemed advisable to include such data, obtained with great difficulty, as a result of extended correspondence with re- mote countries, as evidence of the effort to make the present study as useful as possible for future research. The acceptance or the rejec- tion of any particular group of facts must, after all, remain a matter of individual concern, in view of the magnitude of the undertaking and the truly enormous complexity of the problem of accuracy and com- pleteness. In the case of many of the returns for countries and localities throughout the entire world, with widely varying conditions of govern- mental supervision and control, it would seem a doubtful procedure to reject or exclude data which, after all, may be worthy of serious consideration and therefore useful for the end in view. Cancer a World-wide Menace A summary review of the -available cancer mortality statistics for the civilized world involves unusual difficulties, on account of the widely varying degree of the inherent trustworthiness of the returns for the different countries considered. That the menace of cancer is world- wide is a far-reaching conclusion which can not be successfully contra- dicted by conspicuous illustrations of occasional statistical fallacies or by exceptional instances of inaccuracies in the mortality returns. In the main, the statistics for civilized countries are an approximately trustworthy indication of the tendency of the cancer death rate to approach a maximum of perhaps 130 per 100,000 of population. This maximum is far from having been reached in the case of a large number of countries and representative communities, in which, however, the rate is persistently on the increase from year to year. It 141 THE MORTALITY FROM CANCER has properly been observed that "no statistical judgment deals with the unit but strictly and only with the aggregate." In the case of the present investigation a truly immense amount of statistical information regarding a single disease or a strictly limited group of kindred diseases has been brought together, not for the primary purpose of establishing the causes or conditioning circumstances of the cancer problem, but with the object in view of making the existing statistical data conveniently available for further study and analysis to students of the cancer prob- lem throughout the world. The quality of the data is of course not improved by the mere quantity of the facts collected, but certain in- equalities and errors due to small numbers are eliminated, with the result that the general principles deducible from the facts are more precisely established. Cancer Frequency according to Latitude The foregoing principles of statistical inquiry may properly be applied to the interesting question as to whether there is a clearly established relationship between cancer frequency and latitude. In the following table the facts have been brought together in a readily comprehended form, on the basis of a city population for 1912 of 69,520,000 and a total number of cancer deaths during the five years ending with 1912 of nearly 300,000. The latitude is given by groups in a convenient form, but unfortunately most of the large cities considered are north of latitude 30 degrees, and the aggregate population for cities south of that latitude is relatively small, compared with the number of inhabitants of cities in northern latitudes. Subject to this limitation, however, the table makes an interesting contribution to the geographical study of the cancer problem. Mortality from Cancer in Cities according to Latitude 1908-1912 Rate per No. of Deg Tees of Population Total Deaths from 100,000 Cities Latitude 1912 Population Cancer Population 35 60 N. -50 N. 23,980,086 112,912,675 119,374 105.7 48 50 N. -40 N. 27,519,705 131,256,257 121,216 92.4 24 40 N. -30 N. 10,195,197 47,944,253 37,451 78.1 7 30 N. -ION. 2,780,447 13,476,168 5,696 42.3 4 ION. -10 S. 559,630 2,583,495 1,056 40.9 7 10 S. -30 S. 1,806,951 8,066,144 3,040 37.7 5 30 S. -40 S. 2,678,287 12,297,218 11,048 89.8 130 69,520,303 328,536,210 298,881 91.0 It is shown by this table that the average cancer death rate for 130 of the world's large cities during the period ending with 1912 was 91.0 per 100,000 of population. The rate was highest in the most northern inhabited latitude, or that section of the globe which is comprehended within 50 and 60 degrees north latitude.* The rate for this section was 105.7, diminishing to 92.4 for cities located within 40 and 50 *Thc arctic and antarctic regions are for the present purposes considered as uninhabited portions of the globe. The cancer death rate of Hammerfest, Norway, th; northernmost city of the world (latitude 70° 40' N.), during 1906-10 was 132.0 per 100,000 of population, and 139.8 during 1911. 142 FOREIGN CANCER STATISTICS degrees to 78.1 for cities between 30 and 40 degrees, to 42.3 for cities between 10 and 30 degrees, to 40.9 for cities between 10 degrees north latitude and 10 degrees south latitude, and, finally, to 37.7 for cities between 10 and 30 degrees south latitude. In the most southerly inhabited belt, between 30 and 40 degrees south latitude, the cancer death rate again rises to 89.8, which is practically equivalent to the rate for 30 to 50 degrees north latitude. The table, therefore, would seem to warrant the important conclusion that cancer frequency is to a limited extent determined by latitude, which, of course, more or less determines the climate and weather conditions ; in other words, cancer is excessively common in the temperate zone, moderately common in the medium zone and relatively rare in the torrid or semi-torrid zone, which for the present purpose may be construed to include the belt between latitude 30 north and latitude 30 south.* Cancer Frequency and Longitude On account of the very irregular distribution of the world's large cities a geographical distribution according to latitude and longitu/de is of extremely doubtful intrinsic value. Other factors which determine the cancer death rate are frequently of sufficient local importance to seri- ously disturb the resulting averages derived in particular cases from a relatively small number of points of observation. In the table following the cancer data for 130 cities are given separately for the eastern and western hemisphere, according to latitude, but the data are not intended to be considered as entirely conclusive. Mortality from Cancer in Cities, according to Latitude Eastern and Western Hemispheres, 1908-1912 EASTERN HEMISPHERE WESTERN HEMISPHERE Degree of Latitude No. of Cities Rate per 100,000 Population Index Number No. of Cities Rate per 100,000 Population Index Number 60N.-50N. 35 105.7 98 50N.-40N. 22 108.4 100 26 77.3 100 40N.-30N. 6 66.9 62 18 85.5 111 30 N. -10 N. 3 13.6 13 4 77.2 100 ION. -10 S. 1 11.6 11 3 82.7 107 10 S.-30 S. 1 34.4 32 6 38.2 49 30 S.-40 S. 1 90.1 83 4 89.8 116 Total 69 98.3 61 78.0 The Index Numbers for the Eastern and Western Hemispheres do not indicate a high degree of correlation, largely because of the fact that *The following data (original calculations, based on official statistics) are included for convenient reference, regarding the normal climatic conditions prevailing in the 130 cities, arranged according to latitude: No. of Degree of Mean Annual Mean A Cities Latitude Temperature Rain 35 60 N. -50 N. 48.0° 29.1 48 50 N. -40 N. 50.3° 34.0 ii 40 N. -30 N. 58.5° 37.9 7 30 N.-IO N. 72.5° 57.1 4 ION. -10 S. 74.6° 83.3 7 10 S.-30 S. 65.9° 40.3 5 30 S. -40 S. 62,7° 36.7 143 THE MORTALITY FROM CANCER the data for tropical countries are rather insufficient, and that such cities as Calcutta, Hongkong and Singapore are not strictly comparable with cities like New Orleans, Havana and Paramaribo, etc. Moreover, 60 to 40 degrees north latitude in Europe rather correspond with 50 to 40 degrees north in the Western Hemisphere, as regards climatic con- ditions, but the exact climatological data have not been available in connection with the present study to determine the precise correlation of temperature, rainfall, humidity, etc., to cancer frequency.* Cancer Frequency according to Size of Cities , It is frequently assumed that the cancer death rate of large cities is excessive chiefly because of the exceptional opportunities for cancer treatment, including facilities for surgical operations. It is held that on this account cancer patients from the surrounding country go to the cities for treatment, often in a far-advanced stage of the disease, with fatal results. Such deaths, under existing unsatisfactory methods of registration are not, as a rule, redistributed according to the residence of the deceased, but are included in the mortality of the city where the death occurred. To a limited extent this conclusion is, no doubt, in con- formity with the facts, but its importance is likely to be overrated. In the table following, the cancer death rates of 130 of the world's principal cities have been brought together in three groups, according to size, as to whether the population was 1,000,000 and over or between 250,000 and 1,000,000 or less than 250,000. Mortality from Cancer in Cities, according to Size 1908-1912 Deaths Rate per No. of Population Aggregate from 100,000 Cities Size 1912 Population Cancer Population 14 1,000,000 and over 30,872,254 147,889,255 137,531 93.0 67 250,000-1,000,000 31,907,716 148,806,139 133,286 89.6 49 Less than 250,000 6,740,333 31,840,816 28,064 88.1 130 69,520,303 328,536,210 298,881 91.0 This table, based upon an unusually large number of observations and nearly 300,000 cancer deaths, is of exceptional interest. The table shows that the very large cities had the highest death rate from cancer, or, specifically, 93.0 per 100,000 of population; but this rate was not much in excess of the cities in the next group, for which the rate was 89.6; and the rate in the group following, consisting of relatively small cities, was 88.1, or nearly the same. The table would seem to sustain the con- clusion that the effect of the size of cities on the cancer death rate is not of material importance. To facilitate the convenient study of the general results of this inquiry into the geographical aspects of the cancer problem, the data have been consolidated in the form of a series of tables for large cities, with all the essential facts of latitude, population, *For much valuable statistical information on climate and mortality, with some reference to cancerf see "Mortality of the Western Hemisphere," Panama-Pacific Memorial Publication No. 3, issued in connection with an exhibit on Life Insurance Methods and Results at the Panama-Pacific International Exposition. San Francisco, 1915, by The Prudential Insurance Company of America. 144 FOREIGN CANCER STATISTICS number of cancer deaths and rates per 100,000 of population. The details are given in full in Table 3 of Appendix E. As far as possible, all of the rates used are for the period 1908-12. Comparative Cancer Death Rates of American and European Cities In concluding these observations on the geographical incidence of cancer, it has seemed advisable to bring together the comparative can- cer death rates of twenty large American cities and ten large European cities, for the period 1881-1912. Mortality from Cancer, 1881-1912 Twenty American and Ten European Cities Compared Cancer Death Rate per 100,000 Period Population 1881-1885 48.6 1886-1890 50.7 1891-1895 55.0 1896-1900 60.7 1901-1905 69.5 1906-1910 79.3 1911 83.4 1912 85.4 CITIES EUROPEAN CITIES Index Number Cancer Death Rate per 100,000 Population Index Number Difference in Rates 100 75.4 100 26.8 104 82.0 109 31.3 113 87.9 117 32.9 125 97.2 129 36.5 143 106.2 141 36.7 163 114.4 152 35.1 172 114.7 152 31.3 176 118.3 157 32.9 According to this table, the cancer death rate of American cities during the thirty-two years under observation has increased 76 per cent., whereas for European cities the increase was only 57 per cent. The actual increase, however, in the rate for American cities was 36.8 per 100,000 of population, against an increase of 42.9 for European cities. The actual increase in the rate is unquestionably of greater significance than the relative increase, which depends upon the attained degree of cancer frequency at the beginning of the period under considera- tion. The average cancer death rate for 1912 was 85.4 for American cities, against 118.3 for European cities. The evidence of an actual and relative increase in cancer frequency in American and European cities is clearly established by this analysis, which includes perhaps the largest amount of statistical material regarding a single disease ever taken into account in an investigation of this kind. If the conclusions resting upon the results of this inquiry are not trustworthy, then there is no alterna- tive but to admit that the statistical method has no place in medicine and that the law of large numbers is fallacious in a case where it would seem that it should be most applicable to the facts considered. 145 CHAPTER IX SOME GENERAL OBSERVATIONS AND CONCLUSIONS ON THE CANCER PROBLEM Cancer among Primitive Races — Cancer among the Jews — ^North American Indians — Gypsies — Determinable Factors of Cancer Frequency — Age and Senility — Physical Condition — Growth and Development — Precancerous Lesions — Gastric Ulcers and Gall-stones — Uterine Cancer — Early Diagnosis — Hospital Statistics — Public Institu- tions — Soldiers' Homes — Surgical Aspects — Problem of Recurrence — Duration of Disease — Degree of Malignancy — Clinical Signs — Anaemia — Prognosis — Heredity — Overnutrition — Metabolic Disorders — Vegetarianism — Diet — Civilization — Theory of Atra Bills — Biochemical Aspects — Goitre — Thyroid Carcinoma — Obesity — Alcohol — Smoking — Gall-stones and Chronic Irritation — Tuberculosis — Syphilis — Rheumatism — Gout — Diabetes — Appendicitis — Parasitic Theory — Cancer Houses and Villages — Cancer a Deux or Marital Infection — Surgical Infection — Worry — Insanity — Need of Educational Campaign in Methods of Control — Restatement of Conclusions and Results. An extended statistical consideration of the cancer problem permits of no other conclusion than that the relative frequency of cancer is decid- edly greater at the present time than in former years ; that the disease results in an annual loss in the principal civilized countries of the world of not less than 500,000 lives, and in the United States (1915) of approxi- mately 80,000 lives, and that in this country the cancer death rate is in- creasing at the rate of about 2.5 per cent, per annum. In contrast to a decreasing mortality from preventable causes of death, the mortality from cancer stands foremost as one of the few diseases that are on the increase in the countries for which the official records provide a sufficiently trustworthy basis of conclusive information. In all probability the actual frequency of cancer is somewhat greater than the indicated degree of occurrence as measured by the annual death rate, since a fair proportion of persons suffering from cancer die from other causes, as best illustrated by the occasional instances of the suicide of cancer patients unable to longer endure what has been fitly described as "the agony of a living death." It is also a well-known fact that many surgical operations are successful in prolonging the life of cancer patients, who subsequently die from other causes. The implied menace of cancer is, therefore, more serious than the ascertainable frequency of the disease by means of mortality statistics, but these in the main may be said to reflect with the required degree of approximate accuracy the true liability of civilized mankind to cancer and allied forms of malignant disease*; It is, therefore, not an exaggeration to speak of cancer as a menace and to emphasize its importance as one of the principal causes of death to which more at- tention should properly be directed, both as a medical and as a public question, than has heretofore been the case. Cancer among Primitive Races The rarity of cancer among native races suggests that the disease is primarily induced or at least increased in relative frequency by the con- ditions or methods of living which typify our modern civilization. 146 OBSERl^iTIONS AND CONCLUSIONS Tiicie are no known reasons why cancer should not occasionally occur among any race or people, even though it be of the lowest degree of savagery or barbarism. Grant ing the practical difficulties of determining with accuracy the causes of death among non-civilized races, it is ne^•er- theless a safe assumption that the large number of medical missionaries and other trained medical observers, living for years among native races throughout the world, would long ago have provided a more substantial basis of fact regarding the frequency of occurrence of malignant disease among the so-called "uncivilized" races, if cancer were met with among them to anything like the degree common to practically all civilized countries. Quite to the contrary, the negative evidence is convincing that in the opinion of qualified medical observers cancer is exceptionally rare among primitive peoples, including the North American Indians and the Esquimo population of Labrador and Alaska. Evidence is also available to substantiate the conclusion that cancer was relatively of rare occur- rence among our negro population during a condition of slavery, but that the frequency rate has rapidly increased during the last thirty years, until at the present time cancer of the uterus is proportionately more common among negro women than among the white women living under much the same conditions of life in the same localities. Cancer being an affection more or less liable to attack any part of the human body, the variations in relative frequency in this respect are of especial etiological significance. If the causative or contributory factor of cancer of the cheek in Ceylon is the habit of chewing the betel nut, common to native women, it is self-evident that the disease in this form would not be likely to occur among European women not addicted to that custom. Even more convincing is the evidence regarding specific causative or contributory factors in cancer occurrence met with in the case of the natives of Afghanistan, who are peculiarly liable to the so- called Kangri cancer, or malignant disease of the external abdomen, caused by burns produced incidental to the wearing of a charcoal-stove, on account of the low temperature common to excessive altitudes. No such cancers are met with in civilized countries, where certainly the diagnosis would be made without difficulty, since these cancers are of the external variety. Similar conclusions apply to chimney-sweeps' cancer in England, and Roentgen-ray carcinoma, limited to X-ray workers. For the same reason, cancer of the breast, the uterus, or the stomach may reasonably be supposed to be rare among one class of people and com- mon among another, without regard to accuracy of diagnosis or complete- ness of death certification : in other words, the variations in cancer death rates may be priitiarily explained by decided though possibly not easily ascertainable differences in local conditions, habits, customs, mode of life, etc., and, to a much lesser degree, to possible inaccuracies or deficiencies in diagnosis, etc. Cancer among the Jews The statistical data concerning the comparative cancer frequency among the Jews are rather conflicting. More or less contradictory conclusions result from the use of crude statistics which, generally speaking, are not comparable. The term "Jews" for statistical purposes is, as a rule, inclusive of all persons of the Hebrew faith. 147 TEE MORTALITY FROM CANCER The ethnic and social status of the Jewish population throughout the world, however, varies enormously. The extremes of poverty and wealth are probably greater among the Jews than among any other people. It is self-evident that the mortality statistics of Jews typical of the Ghetto type are not strictly comparable with the statistics of the Jewish population of modern cities, like New York, where they enjoy a considerable degree of material well-being. Physically the Hebrews of to-day are European or Aryan rather than Semitic. It has properly been observed that "the Hebrew is a mixed race, like all our immigrant races or peoples, although to a less degree than most." The Jewish people are divided into two chief divisions: first, the northern type, or Ashkenazim, and second, the southern, or Se- phardim, also called Spanish Jews. The Jews have mixed or inter- married to a considerable degree with all the races among whom they have settled. The Russian Jew represents, as a class, quite a different physical type from the average American Jew. The mortality statistics of the Jews of Warsaw and Budapest are, therefore, not exactly comparable with the mortality statistics of the Jews of the United States. It is necessary to keep these facts in mind to give due weight to the available data regarding cancer occurrence among the different elements of the Jewish population. Fishberg in his treatise on the Jews, with reference to pathological characteristics, refers to a curious statement by Lombroso, that the proportion of deaths from cancer was 2 per cent, for the general population, against 3.3 per cent, for Italian Jews. He quotes Braith- waite as having noticed "that cancer of the uterus was seldom or never encountered among the numerous Jewesses attending the outdoor department of the Leeds General Infirmary." According to the same author, a writer in the British Medical Journal (March 15, 1902) has stated that in his experience cancer of the breast, was often met with among Jewesses in London. Fishberg himself is responsible for the view that "the mortality from cancer among the Russian Jewish immigrants in New York City is much below that of the non- Jewish population." But on the basis of a study of the reports of a large Jewish and of a large Christian hospital in New York City, he concludes that "cancer is by no means rare among them, although less common than among non-Jews," and he adds that "sarcoma appears to be more frequent among the Jews, while cancer of the breast, and especially of the uterus, is less frequently met with among them." The subject is reviewed by Wolff at considerable length. The consensus of qualified opinion would seem to favor the conclusion that cancer is proportionately less common among Jews than among Gentiles and that cancer of the uterus is rare. The most instructive data on the subject have been brought together by Theilhaber, who calls especial attention to the rarity of cancer of the uterus among Jewesses, and in contrast thereto the relative frequency of non-malig- nant fibroid uterine tumors. According to the official statistics of Munich, as quoted by Kirschner, the mortality from cancer of the uterus among Jewesses is much below the average in that city.* *The cancer statistics for Munich for Christian and Jewish women are given in Table 120, Appendix G. 148 OBSERVATIONS AND CONCLUSIONS Auerbach's statistics for Budapest, apparently derived from official sources, show that the general mortality from cancer was about the same for Jews and Catholics, but the rate for cancer of the uterus was only 8.6 per 100,000 for Jewesses, against 24.0 for Catholics, and 26.0 for other confessions. In contrast the statistics of Munich appear to prove that cancer of the breast is relatively more common among Jewesses than among women of the Christian faith. It is regrettable that the available data have not been subjected to a thorough critical analysis. Dr. Felix Theilhaber of Munich, in a contribution to the periodical on Jewish Demography (March, 1910) restates these conclu- sions, largely on the basis of the statistics of Budapest, to the effect that while normally cancer of the uterus accounts for about 35 per cent, of the mortality from cancer among women, and nowhere much less than 25 per cent., the proportion for the Jewesses of Budapest was at most 10 per cent. He adds the interesting observation that this rarity may be attributable to the apparently more normal or abundant blood supply of the generative organs among Jewesses, in contrast to the more or less abnormal and anaemic conditions met with among Christian women of the temperate zone. He quotes Steinhelm to the effect that during a practice of 35 years among the poor of a city with from 25,000 to 30,000 inhabitants, including all classes, he had never met with a single case of cancer of the uterus among Jewesses ! Fishberg has advanced the opinion that the same view is held by leading gynecologists of New York City. He makes the additional statement that "It is well known that carcinoma of the uterus is more often met with in women who have given birth to children than in sterile women, and Jewesses only rarely remain single." Regard- less of their higher fecundity the Jewesses are apparently less liable to cancer of the generative organs. He adds, "What the cause is of this peculiarity, whether it is due to some peculiarity of the ritual dietary laws, or anything else, cannot even be conjectured as long as we are ignorant of the cause of cancer," and he therefore concludes that "At any rate, this seems to be an important field for investigation which may throw some light on the etiology of cancer."* It has not been feasible on the present occasion to make an original statistical study of the comparative frequency of cancer among the Jewish and the non-Jewish population. Knopfel of Darmstadt has brought together the data for a period of years, with a due regard to age and sex, and it is shown that for all ages the comparative mortality from cancer of the Jews exceeds the comparative mortality of Christians, but especially so at ages 70 and over. At all ages the cancer death rate of Christian males was 88 per 100,000, compared with 119 for male Jews; and for Christian females, 116 compared with 177 for Jewesses. These statistics are representative of the Jewish population of the Grand Duchy of Hesse. In Appendix G, on the Cancer Mortality in Foreign Coun- tries, two tables are included for the Jewish population of Vienna. These tables indicate a high cancer death rate on the basis of the estimated population and a high proportionate mortality from cancer on the basis *Maurice Fishberg, "The Jews," New York, 1911. 149 THE MORTALITY FROM CANCER of tlie mortality from all causes, with, however, an apparent tendency during very recent years towards a diminution in frequency (Tables 174 and 175, Appendix G). For Budapest it is shown that the proportionate mortality from cancer was 5.44 per cent, for the non- Jewish population, against 7.01 per cent, for the Jews; but cancer of the uterus occurred in the proportion of 20.2 per cent, of the total mortahty from cancer among non-Jews, against only 7.7 per cent, for Jews. The statistics of Holland confirm this experience, for the pro- portion of cancer deaths in the mortality from all causes in Amsterdam was 5.Q5 per cent, for Jews, against 15.19 per cent, for non-Jews.* As elsewhere observed, there are many convincing reasons for be- lieving that cancer frequency is largely conditioned by the attained degree of material well-being, which in a measure is the equivalent of at least a hypothetical tendency to overnutrition. In view of the wide degree of divergence in social and economic status between the Jews of Europe and the Jews of America, it would seem unsafe to accept the available statistical information as entirely conclusive. For a typical Jewish population living in conformity to the ritual there would, how- ever, seem to be no question but that among this class cancer in general is rare and that cancer of the uterus is exceptionally uncommon. Unfortunately, as observed by W. R. Williams, "Although the compar- ative pathology of the Jew has been fully worked out for most diseases, with regard to malignant tumors the data are scanty and leave much to be desired." But his conclusion would seem to be sound, that "on the whole, however, the available indications point clearly to the con- clusion that the liability of Jews to cancer varies with their mode of life, approximating to that of the people among whom they dwell, but gen- erally being somewhat inferior to it." It should be kept in mind that the proportion of persons of the cancer age is relatively larger among Jews than among Gentiles in Europe as well as in America. The exceptional longevity of the Jew is proverbial, but regardless of this fact the proportion of deaths from cancer is generally below the average. The most recent discussion of the comparative cancer frequency among Jews is found in "The Cancer Problem," by William Seaman Bainbridge. The statistics are derived from the Kosher Wards of the London Hos- pital for the year 1911. Among males the proportion of cancer cases in the total admissions was 5.1 per cent, for Gentiles, compared with 3.3 per cent, for Jews; among females, however, the proportionate figures were 6.2 per cent, for Gentiles, against 6.4 per cent, for Jews. The earlier conclusion regarding the comparative infrequency of cancer of the uterus is confirmed, in that the proportion of such cancer cases among Gentiles was 8.6 per cent., as against 2.9 per cent.for Jews. As said before, all statistics at present available are more or less con- tradictory and inconclusive, but the negative aspect of the evidence is fairly convincing, that cancer is relatively less common among Jews living in conformity to the orthodox principles of their faith, and that •Mortalite par Cancer a Amsterdam pendant les annees 1862-1902, par Feu Le Dr. J. J. Van Konijnenburg, Amsterdam, 1911. 150 OBSERVATIONS AND CONCLUSIONS under normal conditions of life tliey are less liable to the disease, possibly because of their poverty and simple mode of living, especially to cancer of the uterus, than Gentiles of corresponding social and economic status.* Cancer among the North American Indians Malignant disease among North American Indians appears to be ex- tremely rare. A special study of the question made by Dr. Isaac Levin in behalf of the George Crocker Special Research Fund, with the approval of the Commissioner of Indian Affairs, brought out the fact that among an Indian population of 115,000 there had been only 29 reported cases of cancer in the entire medical practice of 107 agency physicians, ranging from an experience of a few months to over 20 years. As observed by Dr. Levin in a paper on "Cancer among the North American Indians and Its Bearing upon the Ethnological Distribution of the Disease," contributed to the Studies in Cancer and Allied Subjects of the George Crocker Special Research Fund (New York, 1912), "Cancer is ex- tremely rare among the Indians as compared with the whites of the same locality, since according to the twelfth census cancer is just as frequent among the whites of the states in which the Indian reservations are located as in other states," and thus "the conclusion must be reached that while it may be true that cancer prevails among all the races of mankind, it is also true that the American Indians living under the same geographical and climatic conditions as their white neighbors may be actually nearly immune from the disease." The infrequency of cancer among the North American Indians can not be attributed to a lower proportion of persons of the cancer age, since according to the approximately accurate data of the thirteenth census the proportion of Indians ages 50 and over was 13.6 per cent., in comparison with 12.3 per cent, for the native white population and 10.4 per cent, for the negro. In the census year 1910 there were 886 deaths from all causes enumerated among Indians living in the registration area, but of this number only 9, or 1.0 per cent., were deaths from cancer and other malignant tumors. The extreme rarity of cancer among North American Indians is further confirmed by a recent inquiry of my own, made with the approval of the Commissioner of Indian Affairs, inclusive of many different tribes, living in 17 different states. The replies received from agency physicians concern a full-blood population of 52,240 and a mixed-blood population of 10,632. Among some 63,000 Indians of all tribes, liv- ing under a variety of social, economic and climatic conditions, there occurred only 2 deaths from cancer as medically observed during the year 1914. The available evidence is therefore quite conclusive that malignant disease is of extremely rare occurrence among the native Indian population of the United States, and the infrequency of the dis- ease suggests the practical importance of further research into the under- lying causes or conditioning circumstances of their apparent immunity, as the case may be. *See in this connection a discussion of the comparative frequency of cancer according to religion and language in Hungary and Budapest, in "Statistik der Krebskranken in den Landern der Ungarischen Heil. Krone," by Dr. Julius Dollinger, Budapest, 1908. 151 THE MORTALITY FROM CANCER Of much interest in this connection are the exceptionally valuable "Physiological and Medical Observations among the Indians of South- western United States and Northern Mexico," by Ales Hrdlicka (Bulle- tin No. 34, Bureau of American Ethnology, Washington, 1908). After an extended inquiry Dr. Hrdlicka remarks that "Malignant diseases, if they exist at all — that they do would be difficult to doubt — must be extremely rare. The writer heard of 'tumors' and saw several cases of the fibroid variety, but has never come across a clear case of epithelioma or other cancer; nor has he as yet encountered unequivocal signs of a malignant growth on an Indian bone." That malignant disease occa- sionally occurs among North American Indians is not to be questioned, but the evidence would seem to be entirely conclusive that cancer is very rare among both the full-bloods and the mixed-bloods of all our Indian tribes. Cancer among Gypsies Thus far no effort appears to have been made to determine with even approximate accuracy the relative frequency of malignant disease among Gypsies. The mode of life of this class of people is so exceptional that an inquiry into the occurrence of cancer among them would make a useful and interesting contribution to the cancer cause. It is regrettable that the elaborate and otherwise most valuable Hungarian Gypsy Census of 1892 was not made to include statistics of mortality by cause, with a due regard to age and sex. A fair proportion of Gypsies attain to the cancer age, for out of 243,000 Gypsies enumerated, 15,600 were 60 years of age and over. To a not inconsiderable extent they still live under extremely primitive conditions. Much valuable information concerning their pathology should be obtainable by means of a qualified analysis of the experience data of the General Hospital at Kolozvar, where for many years special attention has been given to post-mortem examinations. It is by means of special investigations of this kind that the most useful contributions to the cancer cause are likely to be made. Determinable Factors of Cancer Frequency The statistically determinable factors which apparently materially modify cancer frequency are quite numerous though often obscure and peculiarly involved. In other words, the cancer death rate is more or less modified by the age distribution of the population; the variations in sex proportion; the race; the physique; the condition of health; the occurrence of contributory diseases; the climate; the soil; the character of the water supply; the habits, as regards intoxicating drink, food, nutrition; the physical condition, as indicated by height and weight; occupation; the economic condition, as to well-being or poverty; the mental condition, as regards a predisposition to worry; family history or heredity; and the topographic features of the environ- ment, as brought out in the researches of Green, of Edinburgh. In addi- tion, there is the important question in regard to the possible corre- lation of cancer frequency in animals and plants, or at least of diseases similar thereto, and last but not least the possibility, though not the prob- ability, of cancer in its final analysis being infectious and therefore a transmissible disease. It would be utterly hopeless as a statistical and 152 OBSERVATIONS AND CONCLUSIONS mathematical proposition to establish with accuracy and completeness the precise correlation and relative importance of these numerous but specific elementary factors, all of which apparently have some bearing upon the rate of cancer frequency among the different types of mankind and throughout the different countries and localities of the world. Problem of Senility The statement is frequently made that cancer is primarily a function of age; but as elsewhere pointed out, it would be more correct to say that cancer is a function of senility, and even presenility, as made evident by the more common occurrence of sarcoma among the young. In the Industrial mortality experience of The Prudential the proportion of deaths from sarcoma at ages under 30 was 27.9 per cent, of the total mortality from sarcoma, whereas the corresponding proportion for deaths from cancer was only 3.2 per cent. It has properly been observed in this connection by Hastings Gilford, in his treatise on "The Disorders of Post- Natal Growth and Development." Just as innocent tumors show themselves to be true errors of growth by terminating at some period of their career, so the malignant tumors indicate that they are errors of de- velopment by continuing, like normal developments, while life lasts. . . . The carcinomata and sarcomata are not, like the innocent tumors, mere passive accumulations of piled-up cells, but are aggressive, actively invading other parts of the body from those in which they start. In this way they usiu^p the nutrition of the body, and by means of toxins or in some mysterious manner sap its vitality, causing the whole organism to become thin and exhausted, finally bringing about its destruction.* Physical Condition of Cancer Patients Perhaps the most perplexing aspect of the cancer problem individually considered is the marked contrast of the physical condition of the patient during the onset and at the termination of the disease. The authorities are apparently in entire agreement that cancer is more likely to occur among persons otherwise thoroughly healthy than among those of a delicate or non-robust type. As shown by the results of the Medico-Actuarial Investigation, the cancer mortality rate is distinctly higher among persons of overweight, and the inference would seem justified that at least one of the predisposing factors in cancer frequency is overnutrition rather than malnutrition. Many years ago Dr. John Zachariah Laurence, in the Liston Prize Essay for 1854, on "The Diagnosis of Surgical Cancer," observed that "the previous health of the patient gives us but little information. As a rule, it will be found that cancerous patients have been otherwise remarkably free from dis- ease."! He quotes twenty-one cases in which he had noted the previous health, and in sixteen it had been "unimpeachable," and in the remaining five, "any previous illness the patients may have had had been but of a transitory nature." This view is confirmed by one of the most recent authorities on tumors of the abdominal viscera, who holds as regards constitutional peculiarities that "as far as cases in advanced age are *There is a rather suggestive discussion of the mortality from cancer in extreme old age in the new edition of the "Reference Handbook of the Medical Sciences," New York, 1913, Vol. ii, p. 596. f'Mice in poor condition do not offer so favorable a soil for tumor growth as do healthy ones, according to Bashford and Haaland. This may serve to explain the results of those who have described the attainment of resistance by treatment with autolyzed tissues, since the possibility of sepsis in the animals of such experiments ha snot been eliminated." ("Studies in Cancer and Allied Subjects," by the George Crocker Special Research Fund, Vol. i, pp. 137, 200.) 153 THE MORTALITY FROM CANCER concerned, they are mostly individuals of very robust constitution who were never sick; had but little if any infectious diseases; had never been troubled with disturbances of digestion, and in most instances came from very healthy, long-lived families. They are in many ways indi- viduals in whose cases one would be tempted to speak of 'excessive well- being,' which, for that matter, may amount to a cause, owing to the fact that such persons are able to expose themselves much more to dietetic indiscriminations without harmful results for a long time." As regards cancer at younger ages, that is, say between 30 and 40 years, the author observes that the reverse is true, and that in this group the patients frequently are individuals inclined to weakness and have a general aspect that is decidedly phthisical, pallor of the face, etc. He further points out that this class of individuals are most likely to become afflicted with lympho-sarcomatous processes.* W. R. Williams, in his "Natural History of Cancer," referring especially to cancer of the uterus, remarks that "the great majority of such persons whose life history he had investigated had been well-fed and well-housed, having had nothing to do but to look after their own domestic establishment. They bad usually enjoyed excellent health, most of them having had no serious illness since youth, rheumatic fever and rheumatism being the com- monest diseases from which they had suffered." Elsewhere in his work the same author observes that "cancer is a disease of persons whose previous life has been healthy and whose nutritive vigor seems to promise long life. Long-continued observation of cancer patients in the early stage of the disease has convinced me that most of those affected are large, well-nourished persons who appear to be overflowing with vitality .f Such types are indicative of hypernutrition. The small, pale, ill- nourished and overworked women of the type so familiar in Lancashire and other industrial centers, are seldom afflicted with this disease." Some forty years earlier Charles H. Moore, in several contributions to the British Medical Journal, gave utterance to much the same conclusions, stating that cancer was chiefly a disease of healthy and strong persons, to which he adds the curious and interesting observation, subsequently neither confirmed nor reinvestigated, that cancer was more common among the first-born. These observations are of profound significance in connection with the objects and aims of a nation-wide effort at cancer control, which, in brief, amounts to no more and no less than the de- liberate reduction of the cancer death rate, on the basis of the earliest possible diagnosis and the prompt recourse to approved methods of treat- ment and cure. It is notoriously the healthy and the strong who are least willing to concede the latent possibility of early death. It is this *Rudolph Schmidt, "Diagnosis of the Malignant Tumors of the Abdominal Viscera," p. 50, English trans- lation by Joseph Burke, New York, 1913. fSome very interesting investigations have been made by Miss E. Atlee, regarding the maximum of the lifetime weight curve of uterine cancer patients. The results of her researches are summed up in the statement that body weight attains to its maximum during the years immediately preceding the onset of the disease, and that health and strength remained normal during the same period. In the case of controls (women suffering from other forms of malignant disease) it was found that the body weight had been at its maximum, not during the years immediately preceding the appearance of the disease, but much earlier in life, at which time health and strength, though maximum, had not been necessarily normal. The investigation was apparently not carried through with complete facilities for statistical analysis. The line of inquiry, however, would seem to suggest possibilities of practical value in suggesting a means of an early diagnosis of at least uterine cancer, and event- ually perhaps throw new light on the cancer question in general. 154 OBSERVATIONS AND CONCLUSIONS class which is most optimistic and least apprehensive when first con- fronted by faint signs or indications of more or less obscure forms of physiological disturbances. Since cancerous growths are without nerves, pain is absent, as a rule, until the growth has attained to suffi- cient proportion to press by its weight upon adjacent parts and thus produce a sense of discomfort, which is frequently assumed to be but a passing phenomenon, and, in any event, one which as a rule does not suggest serious future possibilities. Problem of Growth and Development Innumerable and varied indeed are the alleged causes or conditioning circumstances of malignant disease. In its final analysis the problem of cancer becomes merged with the problem of life, growth, development and death. In the vast domain of medicine there is no other disease which resembles it in its essential manifestations and obstinate resistance to treatment other than by radical methods. The term cancer is used here in the generic sense* merely as a matter of convenience, for even the most painstaking classification fails in rare individual cases, since exceptions to established rules, according to Miller, "are so frequently met with in relation to neoplasms, that the most elaborate system breaks down at many points, unless each tumor be placed in a category by itself." Charles Powell White has directed attention to the analogous cases of mutations and bodily variations which play such an important part in biology. Precancerous Conditions Precancerous conditions, as defined by Rodman, may be internal as well as external; and moreover, it is, to say the least, suggestive that "such precancerous conditions are inflammatory, inasmuch as a mild, low-grade chronic inflammation, due to long standing irritation and resulting in either ulceration, hyperplasia, or cicatricial tissue is present in all of them," and "this in turn means diminished arterial supply with lessened physiologic resistance of the cells undergoing metaplasia, and while there may be in addition something more necessary, extrinsic or intrinsic, to initiate the cancer process this much is always present, a suitable soil, if you please, and would seem enough in itself to cause cancer."t Foremost among precancerous conditions, according to Parker Syms, are benign tumors, chronic ulceration, chronic inflamma- tion, and abnormal tissue, such as scars, and prolonged irritation. The experience and researches of Keen and Bloodgpod are referred to as tending to prove, with reference to pigmented moles, that these growths are prone to become cancerous, and an enumeration is made of sixty- five cases of malignant moles operated upon, in every case of which the diagnosis was confirmed by microscopic examination. But, by way of contrast, seventy-six other cases of benign pigmented moles are cited, which "were removed in the precancerous stage," and with regard to which it is stated that "there have been no local recurrences and no deaths from internal metastases."! *The clinical characters of cancer as a basis for classification is fully discussed in a lecture on "The Biology nf Tumors," by C. Mansell Moullin, M. D., in The Lancet, March 21, 1914. See also page 166, et seq., on the degree of malignancy, rapidity of growth and clinical signs. tAnnals of Surgery, January, 1914. IMedical Record, May 17, 1913. 155 THE MORTALITY FROM CANCER The exact correlation of cancer to other diseases has not been established, but qualified investigations in this direction would un- questionably prove productive of valuable results. The data require to be considered with extreme caution, and in many cases correction will be necessary for variations in sex and age distribution, and possibly other conditioning circumstances. Such investigations should be carried on in connection with the more minute study of the anatomical findings in trustworthy autopsy records, by means of which the primary lesions of cancerous growth may be precisely determined. Carcinomata, according to Miller, "occur (1) at or near the orifices of the body — lip, tongue, rectum, vagina; (2) at points where normally there is narrowing of a canal — pylorus, ileo-caecal valve; (3) at points where a canal changes its direction — ^hepatic, splenic, sigmoid flexures of large intestine; (4) in glands such as the mammary, and in organs such as the uterus, which are periodically undergoing hypertrophy and involution. In other words, there is a marked association of cancer with chronic irritation of various kinds."* The term irritation is used here in a very general sense. The irritation need not necessarily be mechanical, but may be purely physiological or pathological or even chemical or in the nature of overstimulation of physiological functions incident to metabolism. Gastric Ulcers and Gall-stones As of special interest in connection with this brief dicussion of pre- cancerous conditions, a reference may be made to gastric ulcers and gall-stones. In the experience of the Mayo clinic, Rochester, Minne- sota, "it has been shown that between 60 and 70 per cent, of cancers of the stomach have developed in the site of a preexisting gastric ulcer,t or in the cicatrix of an ulcer which had been healed," and the conclusion is therefore confirmed by Parker Syms that "we must consider gastric ulcer as a precancerous stage of more than two-thirds of the gastric cancers." Concerning gall-stones as a predisposing condition, the same authority concludes that "in practically 100 per cent, of cases of primary cancer of the gall bladder and bile ducts gall-stones may be found, and it may be demonstrated that they have existed for a long period before a cancer developed." J. Bland-Sutton, in a brief discussion of cancer of the gall-bladder, in his treatise on "Gail-Stones and Diseases of the Bile-Ducts," remarks that "this disease [cancer] has in recent years at- tracted a large amount of attention; this is in a measure due to its in- timate association with gall-stones, though this fact has long been recog- nised. . . . Careful investigations on this point prove that in at least 95 per cent, of cases gall-stones are present, and this has induced surgeons to regard the presence of biliary concretion in the gall-bladder as a precancerous condition. It is, however, a curious fact, and one worth bearing in mind, that although cancer of the gall-bladder is nearly always complicated with gall-stones, this association is quite exceptional when primary cancer arises in the common bile-duct or the ampulla." The special importance from a statistical point of view of •James Miller, "Practical Pathology, including Post-Mortem Technique," New York, 1914, p. 297. fit may be properly stated in this connection that Dr. Wm. L. Rodman is generally credited by the medical profession as having been the first toadvise the removal of gastric ulcers on account of the inherent tendency to degenerate into malignant affections. 156 OBSERVATIONS AND CONCLUSIONS this observation lies in the fact that there has been a decided increase in the frequency of gall-stone mortality in certain civilized countries, corresponding more or less to the increase in the mortality from cancer. Prognosis of Precancerous Lesions Important practical consequences must necessarily result from a general acceptance of the doctrine of precancerous lesions. It, of course, does not necessarily follow that the discovery of such lesions assures in every instance that the process is likely to terminate in a cancerous growth; but the indications are invariably of profound prog- nostic significance. As observed by Ewing,* "If inoperable advanced cancer is incurable, and localized cancer eradicable, the disease is pre- ventable by dealing with its preliminary stages. Precancerous lesions are not cancers. Practically they differ enormously from the estab- lished disease. They can usually be removed by trivial or safe opera- tions, and they are sometimes amenable to less violent treatment." "Gastric ulcers, lingual warts, fissures, and plaques, eroded cervices, pigmented moles, and benign tumors, are everywhere excised," accord- ing to this writer, "with the conviction that a malignant tumor may thereby be prevented, but the relation between the benign and the malignant process is still under discussion and often frankly doubted." Uterine Cancer The recognition of precancerous conditions would appear to be of especial importance in the case of cancer of the uterus. According to Parker Syms, "there are many conditions which predispose to these cancers, such as simple tumors of the uterus, chronic inflammation of the organ, and chronic ulceration, or so-called erosion, usually the result of neglected laceration and tears." The conclusion would therefore seem justifiable that "All these abnormalities should be remedied because they are precursors of cancer." In the uterus, as stated by Ewing, chronic catarrhal endocervicitis precedes cancer in the great majority of cases, and the cervical erosion is the most definitely established lesion known to precede cervical carcinoma. In the case of the body of the uterus the chief definite etiological factor, according to the same authority, is the association with myoma, which is a tumor composed of mucular tissue, or a tissue of the same nature as the con- nective tissue of the embryo and of the umbilical cord, and vitreous humor. This tumor is not malignant in itself, but there is apparently a well-established liability of its assuming a cancerous form. Considerations of this nature are extremely involved pathological and medical problems, which hardly, as yet, permit of being subjected to qualified statistical analysis. The references are included as illustrations of perhaps the most important phase of the cancer problem individually considered; since in proportion as the laity can be made to recognize the value to be attached to precancerous lesions, the outlook for suc- cessful medical and surgical treatment must be materially increased. Difficulties of Early Diagnosis In this connection the following observations by Dr. Thomas S. Cullen are of especial interest. As regards cancer of the tongue, Dr. *J. Ewing, M. D., "Precancerous Diseases," Medical Record, December 5, 1914. 157 TEE MORTALITY FROM CANCER Cullen points out that the milky patches on the tongue of smokers, if removed at once, would result in no further trouble; but if one waited without interference carcinoma would unquestionably develop. In carcinoma of the lip, if the radical operation were performed, the chances of complete recovery would be considered good. In carcinoma of the stomach, pathology did not as yet aid very much, and if one waited for the stomach-washings to show the characteristic lesions as a pre- requisite to a correct diagnosis, it would usually be so late in the course of the disease that little could be done for the patient. It is therefore suggested that an exploratory operation should be made to determine whether cancer was present or not. The surgeon, as well as the pathol- ogist, he points out, was aided in this respect by a fluoroscopic examina- tion, which was destined to play a large role in the making of early diag- noses. If one were dealing with a carcinoma of the intestines, signs of obstruction appeared fairly early, and more and more cases were now ap- parently cured by early operation. The pathology here was quite char- acteristic. Cancer of the rectum and lower sigmoid could be detected by the proctoscope, and by its use many early diagnoses were now made. In fact, with the proctoscope a diagnosis was relatively easy in the majority of cases. There are, he concludes, two common types of special importance, cancer of the breast and cancer of the uterus. Cancer of the breast in the early stages might have been beneath the skin and there might not have been any adhesions or puckerings, but as the disease advanced this characteristic puckering of the skin occurred. If one cut into the growth and removed a local area, the portion could be imme- diately recognized ; if it proved to be cancerous, a complete and radical op- eration should be done, together with the removal of the axillary glands.* Cancer Hospital Statistics It is most regrettable that the statistical reports of cancer hos- pitals should be of such limited practical usefulness. The conclusion applies also to the reports of the larger general hospitals, with the exception of the Johns Hopkins Hospital of Baltimore, which for more than twenty years has published the required statistics in sufficient detail. There is an urgent need of a national movement for uniform methods of tabulation and analysis of statistics, at least of the larger general hospitals and special institutions for the treatment of cancer patients. At present the available data can not be utilized to much practical value in a statistical study of the cancer morbidity and mortality problem, with a due regard to the essentials of age, sex, race and the organs and parts of the body affected. To a limited extent, of course, the existing statistics are useful, if but to emphasize the fact that in the main the results of institutional treatment, at least for certain forms of cancer, are distinctly encouraging. The statistics of the Charity Hospital of New Orleans, for illustration, as given elsewhere in this work show in some detail, the results of treatment by race, but the data, unfortunately, are not given according to sex. In the experience of this notable institution during the period 1910-14, for both races combined, the fatality rate for cancer of the buccal cavity was 14.8 per cent.; for cancer of the stomach and liver, 44.5 per cent.; for cancer * Medical Record, New York, April 26, 1913, 158 OBSERVATIONS AND CONCLUSIONS of the peritoneum, intestines and rectum, 37.2 per cent. ; for cancer of the female generative organs, 15.9 per cent.; for cancer of the breast, 11.3 per cent.; for cancer of the skin, 13.1 per cent.; and for cancer of other organs, 22.8 per cent. For all forms of cancer combined, the fatality rate was 21.1 per cent. For white patients, separately considered, the fatality rate was 21.1 per cent. ; for colored patients, 20.9 per cent. The experience includes medical, surgical and gynecological cases. Of the total number of cancer patients, 170 were cases of sarcoma, and 1,349, epithelioma and other carcinomas, including rodent ulcer. The fatality rate among sarcoma cases was 30.6 per cent., and among carcinoma cases, 22.0 per cent. In the experience of the American Oncologic Hospital of Philadelphia for the period 1909-13, the fatality rate for cancer of the buccal cavity was 13.2 per cent.; for cancer of the stomach and liver, 44.4 per cent.; for cancer of the peritoneum, intestines and rectum, 16.7 per cent. ; for cancer of the female generative organs, 27.5 per cent. ; for cancer of the breast, 28.6 per cent. ; for cancer of the skin, 10.2 per cent. ; for cancer of other organs and parts, 25.3 per cent.; and for all forms of cancer com- bined, 21.7 per cent. Out of a total of 314 cases of mahgnant disease, 19 were cases of sarcoma and 295 were cases of epithelioma and other forms of carcinoma, including rodent ulcer. The fatality rate for sarcoma cases was 26.3 per cent., and in the remainder of the group of malignant diseases, 21.4 per cent. The statistics of the Johns Hopkins Hospital have been discussed in some detail in another portion of this work. At the present time these statistics are the most conclusive, differentiating the white and the colored patients according to sex and specific organs and parts of the body affected by malignant disease. For a more extended discussion the analysis and experience data of this hospital for the period 1892-1911, published as a monograph of the new series of Johns Hopkins Hospital Reports No. 4 (Baltimore, 1914), should be consulted. The statistics of the General Memorial Hospital of New York City are subject to the same inherent limitations as those of the Charity Hospital of New Orleans and the American Oncologic Hospital of Philadelphia. It is also quite apparent that these statistics have refer- ence to lesions observed and recorded rather than actual cases and deaths of patients under treatment; in other words, a patient suffering at the time of death from several cancerous lesions would be recorded accord- ingly, and not only once as is essential for general statistical purposes. Serious errors are certain to result from crude methods of tabulation and analysis. It is most regrettable that the statistical aspects of the cancer problem should have been so superficially considered in the reports of special institutions for the treatment of cancer patients. In the annual reports of the Barnard Free Skin and Cancer Hospital of St. Louis, with others, no information whatever is given regarding results of treatment, nor are the data given separately according to sex. The same conclusion applies to the annual reports of the Free Cancer Hospital of Brompton, London, which is even more important, since the experience of this notable in- stitution extends over 63 years. 159 12 TEE MORTALITY FROM CANCER Practical Value of Uniform Hospital Statistics In view of the urgent demand for trustworthy cancer morbidity and mortahty statistics, it is self-evident that the institutions which fail to provide the required amount of trustworthy and comparable statistical information fail materially in the full discharge of their duty towards their patients, their patrons and the public at large. Such institutions are much more likely to advance their own interests by a full and frank publication of the results than by the present methods of crude and superficial statistical tabulations, which serve no practical purpose, but, much to the contrary, hinder the cause of cancer education and discourage treatment by approved methods under proper institutional conditions. Subjected to quaUfied statistical analysis, the experience data of American general hospitals and special cancer institutions should prove of great value in the furtherance of the scientific study of the disease. As a first step towards an urgently required reform, an understanding should be arrived at on the part of the principal institutions to report and publish the facts of their annual experience in a uniform and strictly comparable manner. Such reports would in all probability be less ex- pensive, and certainly much more useful, than the present methods in common use. The annual reports should be amplified by additional statistics of autopsy records, subjected to qualified analysis, so as to establish with greater precision the probable coexistence of cancer and other diseases. Extreme care, of course, is always necessary in the interpretation of the data published for general use. The statistics of Orth for Berhn, indicating a substantial increase in the percentage of cancer diagnoses made in the case of autopsies, from 4.9 per cent, in 1875, to 7.0 per cent., in 1885, and 14.1 per cent., in 1907, do not, for illustration, warrant the conclusion that cancer in Berlin during this period has increased at such a rate. The data of Lex for Heidelberg are more convincing. Lex shows that the proportion of cancer cases in autopsies increased from 6.6 per cent, during the period 1870-79 to 9.13 per cent, during 1900-07. Reick has reported the results for Munich for a long period, showing a cancer proportion of 7 per cent, in autopsies during 1854-63, compared with 12.5 per cent, during 1894-1903. These percentages, however, have reference only to bodies of persons ages 15 and over. Steinliaus of Brussels compares more recent data of bodies of persons 20 years and over, showing an increase from 8.6 per cent, during 1888-97 to 9.1 per cent, during 1898-1907. Finally, Buday of Xolozvar reports 8.0 per cent, of cancer bodies during 1870-88, compared with 9.9 per cent, during 1889-1905. These statistics are quite conflicting, and it is doubtful whether they can be even approximately considered com- parable, in view of the absence of uniform methods of anatomical diagnosis and selection of cases for post-mortem examinations. As observed in the article on cancer in the Reference Handbook of the Medical Sciences, from which the preceding statistics have been derived, the rise in cancer frequency may well be explained by the fact that "cancer patients are much more apt to seek treatment in the hospitals nowadays than a few years ago." But Orth is quoted to the effect that if every allowance is made the autopsy statistics show a moderate increase in the incidence of cancer.* '"Reference Handbook of the Medical Sciences," New York, 1913, Vol. ii (article on cancer). 160 OBSERVATIONS AND CONCLUSIONS In the foregoing observations the main point of view has been the practical utihty of cancer hospital statistics to determine at least ap- proximately the results of institutional treatment. It, of course, is essential that the facts should be separately stated for the medical and the surgical as well as for the gynecological department. This has been done in the statistics of the Johns Hopkins. Hospital, which it has been found feasible to precisely correlate to the corresponding population by race and according to sex. An equally important purpose, however, is to determine with a close approach to accuracy the distribution of cancer morbidity in sufficient detail, so as to bring out the occurrence of rare forms of the disease, as well as the preponderating mass of the more common forms. In all mortality statistics it would be advisable to separate the sarcoma cases from the carcinomata and to give the in- formation by age and sex, as has been done in an admirable manner in the returns of metropolitan hospitals pubhshed for the year 1905 in the statistical investigations of cancer by the Imperial Cancer Research Fund. An even more scientific classification was adopted in the sta- tistics published in the second annual report of the Harvard Cancer Com- mission differentiating carcinoma and sarcoma as well as special tumors and tumor-like conditions, border-line growths and benign growths. In detail, there were treated at the Colhs P. Huntington Memorial Hospital during the year ending June 30, 1914, 198 carcinoma cases, 11 sarcoma cases, 19 special tumors and tumor-hke conditions, 14 border- line growths and 8 benign growths, a total of 250 cases, of which 4.4 per cent, were cases of sarcoma. For reasons which can not be dis- cussed at length, the experience of every hospital providing special treatment for cancer patients is likely to be at variance with the expe- rience of other though similar institutions. The results of treatment, also, will probably never permit of exact comparison, in that the quali- fications or conditions on admission naturally must vary widely according to the class of patients treated. It is reasonable to suppose that in pub- he practice the proportion of advanced cases w^ll be much larger than in private practice, and the same conclusion apphes to white and colored patients, in that it is a safe assumption that the latter would seek treat- ment at a later stage of the disease than the former. _ All of these statistical difficulties only tend to reemphasize the earlier conclusion that there is the utmost urgency for the general adoption of uniform methods of tabulation and analysis on the part of at least the more representative institutions for the treatment of cancer throughout the United States. If this suggestion is carried into effect, it is certain that the results will prove of substantial advantage in the furtherance of cancer research. Cancer Deaths in Public Institutions The institutional aspects of the cancer problem are further illustrated by some recent statistics for England and Wales. It is shown that out of 16,188 deaths of males from cancer, 2,640, or 16.3 per cent., occurred in Poor Law Institutions; 157, or 1.0 per cent., in lunatic asylums and 2,015, or 12.4 per cent., in hospitals. Among females, out of 21,135 deaths from cancer, 1,928, or 9.1 per cent., occurred in Poor Law In- stitutions; 216, or 1.0 per cent., in lunatic asylums, and 1,862, or 8.8 per 161 THE MORTALITY FROM CANCER cent., in hospitals. The proportion of deaths from all causes occurring in hospitals was 8.9 per cent, for males (as compared with 12.4 per cent, for cancer), and 6.9 per cent, for females (as compared with 8.8 per cent, for cancer). The proportion of cancer deaths outside of hospitals was 70.3 per cent, for males and 81.1 per cent, for females. The statistics are of much practical importance, and it should not be difficult to ascertain the corresponding proportion of hospital cancer cases, at least for the larger cities of this country.* Cancer in Soldiers' Homes The occurrence of cancer among special classes warrants much more extended statistical consideration than is usually the case. There are many sources of useful information now neglected which in course of time, no doubt, will be made use of to much practical advantage. Among others, a more qualified study should be made of the occurrence of mahgnant disease among inmates of our national homes for disabled volunteer soldiers. During the period 1906-14 there were 300,343 veteran soldiers cared for, among whom there occurred 2,191 cases of malignant disease, of which 887, or 40.5 per cent., terminated fatally in proportion to the number under observation. The cancer mortality rate was 300 per 100,000 exposed to risk. This apparently very excessive rate is, of course, largely, if not entirely, due to the high average age of the inmates, which is approximately 69 years. The experience illustrates the danger of using crude statistics of cancer morbidity or mortality without a due regard to the age distribution of the population considered. It would be extremely interesting to know the relative frequency of the different forms of cancer among this rather exceptional class of persons, but un- fortunately the medical statistics in the annual reports of the Board of Managers of our National Homes for Disabled Volunteer Soldiers do not furnish the required details. Surgical Aspects A critical discussion of the medical and surgical aspects of the cancer problem lies outside the scope and plan of this work. The statistical analysis of surgical experience, whether institutional or private, is beset with many difficulties which have their origin in the nature of the case, that the condition of the patients on admission must necessarily vary widely, while at the same time fundamentally conditioning the results of operative treatment and the duration of the future lifetime of surviv- ing cases. A collective investigation would unquestionably produce much interesting information and meet some of the difficulties which arise out of the paucity of the data derived from small institutional or limited private clinical experience. It is remarkable that the statistics of large hospitals, which might yield much useful information, have with few exceptions not been presented in a useful form in the annual reports of even large and influential public institutions. An extended analysis of the data of the Johns Hopkins Hospital, Baltimore, sustains the con- clusion that the immediate results of operative treatment are quite favorable in the majority of cases, as shown by the table following, derived from "The Menace of Cancer," in the Transactions of the American Gynecological Society, for 1913. *Annual Reports of the Registrar-General for England and Wales for 1912 and 1914. See also note to Table 2, Appendix B. 162 OBSERVATIONS AND CONCLUSIONS Cancer Statistics of Johns Hopkins Hospital, Surgical Department Cases by Sex, 1902-1911 WHITE PATIENTS Males Females Cases Deaths Per Cent. Cases Deaths Per Cent Buccal cavity 130 15 11.5 13 1 7.7 Stomach and liver 110 26 23.6 56 13 23.2 Peritoneum, intestines, rectum. 88 19 21.6 35 9 25.7 Female generative organs 3 2 66.7 Breast 251 14 5.6 Skin 40 4 10.0 10 Other or not speciJfied organs . . . 435 57 13.1 117 7 6.0 All organs 803 121 15.1 485 46 9.5 According to this table the fatality rate was 15.1 per cent, for males and only 9.5 per cent, for females, but this, of course, is exclusive of the ex- perience with gynecological cases, which are separately given in the table following: Cancer Statistics of Johns Hopkins Hospital, Gynecological Department Cases, 1902-1911 WHITE PATIENTS Cases Deaths Per Cent. Stomach and liver 8 3 37.5 Peritoneum, intestines, rectum. . 23 2 8.7 Generative organs 331 35 10.6 Breast 2 Skin Other or not specified organs .... 39 5 12.8 All organs 403 45 11 .2 The foregoing tables are restricted to the white patients, since the data for colored patients are rather limited, with the exception of cancer of the generative organs. The facts are briefly given in the table below : Cancer Statistics of Johns Hopkins Hospital, Gynecological Department Cases, 1902-1911 COLORED PATIENTS Cases Deaths Per Cent. Stomach and liver 1 Peritoneum, intestines, rectum. . 6 1 16.7 Generative organs 78 9 11.5 Breast 1 Skin Other or not specified organs .... 16 2 12.5 All organs 102 12 11.8 163 THE MORTALITY FROM CANCER Postoperative Results There have been few quahfied investigations as regards postoperative results. The published statistics are, as a rule, too limited in the number of cases available and too indefinite as regards the tracing of all of the patients for the required length of time after the date of the operation. A considerable amount of interesting information on this phase of the cancer problem has been brought together by Charles P. Childe, in his treatise on "The Control of a Scourge," published in 1906. As a first step in the direction of systematically observing the results of institu- tional treatment, the Massachusetts General Hospital has adopted a follow-up system which in course of time should yield results of great practical value. As an illustration of the results obtained by means of qualified surgical treatment, the following observations by Dr. E. S. Judd of Rochester, Minn., based upon his experience in the Mayo clinic, are here included: Of the 514 patients of whom the subsequent history is known, 266, or 52 per cent., are known to be dead, though 21 of these died from other causes without cHnical signs of recurrence of carcinoma, leaving a balance of 48 per cent, of deaths, probably from cancer, for the entire series. Two hundred and forty -eight of the 514 patients were known to be alive from 2 to 11%2 years; 37 of these were known to have recurrences. Of the patients operated on during the years 1902 and 1903, 40 have been traced, 27 were known to be dead from various causes, leaving a percentage^ 33 ahve without recurrence for more thati ten years. Three of those who died lived more than 6 years and died from other causes. Of the 321 patients operated on more than 5 years, 266 were traced; 148 were known to be dead and 106 living, a percentage of 40 who had lived more than 5 years. Six of the living had recurrences. Fourteen of these dead had died from other causes than cancer. Of the 510 patients operated on more than three years, 437 had been traced; 234 were dead, 191 living, a percentage of 45 patients living more than 3 years. Twenty-seven of these had recurrences. Nineteen of those dead had died from other causes. One case was reported of a patient who died 91/2 years after the primary operation from general carcinosis; one from internal metastases without local recurrence'6%2 years after operation; and one on whom a secondary operation for recurrence was done 12 years after the primary operation. In this latter case the patient remained well nearly three years after the secondary operation.* Problem of Recurrence The surgical aspects of the cancer problem suggest a brief reference to the related factor of recurrence, by which is meant "the reappearance of malignant disease in the locality occupied by the primary tumor, in the immediate neighborhood, in the regional lymph nodes, or in the distant parts of the body, after operative or other interference that has ap- parently insured the destruction of the disease." As observed in the article on cancer in the Reference Handbook of the Medical Sciences,! "Recurrence in the lymph nodes or in the distant organs must be explained by the assumption that dissemination of the disease has taken place even before the operation. Examples of very late recurrences many years after the operation have forced the assumption of a possible latency of cancer cells; thus, a pigmented cancer of the liver appearing many years after the extirpation of the primary disease affecting one eye is best explained by such a hypothesis. Late local recurrence, on the other hand, may be interpreted as a result of continuation of the same conditions as have led to the appearance of the primary malignant *Medical Record, February 21, 1914. f'Reference Handbook of the Medical Sciences," New York, 1913, Vol. ii, p. 601. 164 OBSERVATIONS AND CONCLUSIONS disease. " In the article referred to, W. R. Williams is quoted to the effect that sixty-four per cent, of all mammary cancer recurrences take place within the first six months after operation, and about two-thirds of these appear within the first three months. The new cancer centers may be followed by second or even third recurrences after operative removal; occasionally even more numerous recurrences have been observed, though usually the disease is either destroyed by the repeated operations or the patient succumbs to involvement of distant parts of the body. On the question of recurrence much has been written to small purpose. The statistical determination of the results involves serious practical difiiculties, which are quite similar to those met wdth in investigations of post-discharge results in the sanatoria treatment of tuberculosis. Duration of Disease The probfem of recurrence is closely allied to the question of disease duration, which particularly in cancer has not been determined with accuracy, even in regard to the period intervening between the appear- ance of the first serious symptoms demanding medical treatment and the fatal termination of the case. The statistics of the New York State Institute for the Study of Malignant Disease, elsewhere discussed, throw some light on this phase of the cancer problem, but the data require to be used wath extreme caution. As observed by Rudolph Schmidt in his treatise on' the "Diagnosis of the Malignant Tumors of the Abdominal Viscera," the duration of the disease manifestations from their first appearance to their ending by death naturally varies within wide limits. In only a single instance of his case histories was there a probability of three years' duration, but not infrequently cases were found to extend over two years and several months, so that cases running over a period of two years could not be considered rare, and the facts available would seem to prove that a correct diagnosis could have been made at the beginning- of the disease. Dr. Otto of Copenhagen, at the second International Conference on Cancer, held in Paris in 1910, gave an interesting account of the duration of malignant disease of the digestive tract, demonstrating the shortness of the period betw^een the first symptoms and death in 196 cases, and concluding that "the first symptoms appeared and the clinical diagnoses were made subse- quent to a long latent period, of which the duration depended upon •anatomical and other factors."*- The Pennsylvania Cancer Commission, in an investigation of 400 cases, according to Dr. John A. Hartwell, found that Superficial cancer had been apparent on an average of eighteen months before the case came to the surgeon, and eleven months had elapsed between the time that a surgeon had been consulted and the date of the operation. In deep cancers this time was one year. About one case in thirty of breast cancer was not even examined by the first physician consulted, and in one case in six, salves, ointments, etc., were prescribed, with ad^^ce to temporize. Sixty-eight per cent, only of superficial cancers were operable when they came to the surgeon. Only 48 per cent, of deep-seated cancers were operable when first seen by the surgeon. In a 'series of cases covering five years in a representative hospital over 63 per cent, of the cancer cases were foimd totally inoperable.f *British Medical Journal; October 22, 1910. iiledical Record, New York, April 26, 1913. See also report to Medical Society of Pennsylvania by its Commission on Cancer, by J. M. Wainwright, Chairman, Harrisburg, Pa. 165 TEE MORTALITY FROM CANCER In this connection the following table, derived from the special report on cancer in Ireland, showing the duration of previous illness accord- ing to sex, for all cancers, and separately for cancer of the stomach, uterus and breast, is included as an interesting illustration of the utility of even crude statistical methods in rendering aid to the cause of cancer research. Mortality from Cancer in Ireland, by Organs and Parts, and Duration of Illness, according to Sex, 1901 Males Duration of All Organs Stomach Illness (Per Cent.) (Per Cent.) Under 6 months 34.0 41.6 6 months-1 year 37.0 36.7 1-2 years 21.1 19.6 2-3 years 4.2 1.2 Over 3 years 3.7 0.9 Total with known duration 100.0 100.0 Females All Organs (Per Cent.) 30.7 35.5 24.1 5.5 Stomach (Per Cent.) 39.0 34.6 21.3 3.5 1.6 Uterus (Per Cent.) 20.3 46.5 26.2 3.8 3.2 Breast (Per Cent.) 11.2 32.5 37.7 10.8 7.8 100.0 100.0 100.0 100.0 (For details see Tables 47 and 48 of Appendix G.) It is brought out by this interesting analysis that the proportion of cancer deaths with a previous disease history of over 3 years was 3.7 per cent, for males, and 4.2 per cent, for females, of the cases with a known duration. For cancer of the stomach the corresponding pro- portion was 0.9 per cent, for males, and 1.6 per cent, for females; for cancer of the uterus, 3.2 per cent.; and for cancer of the breast, 7.8 per cent. In the majority of cases of known duration the disease had been in existence or had been observed by the patient for at least six months or over.* For cases of known duration the proportion of cancer deaths with a previous history of over 1 to 2 years was 21.1 per cent, for males, and 24.1 per cent, for females. Accepting the principle laid down by the American Society for the Control of Cancer, that "in the early recognition and treatment of the disease lies the hope of a cure," it is self-evident that a fatal termination could in many cases be prevented by the avoidance of needless and hopeless delay, f Degree of Malignancy The previous duration of cancerous disease is primarily conditioned by the type of the cancerous growth, which is subject to a varying degree of malignancy, in turn affected by the powers of disease resistance, which are also subject to wide variations. There are, for illustration, the slow growing tumors, arising from fibroblasts, called fibromata, and the rapidly growing fibrosarcomata, which, according to F. B. Mallory, "represent extremes in the rate of growth." The duration of the disease *Some interesting facts are disclosed by the analysis of the Ordinary Ejrperience of The Prudential Insur- ance Company of America for the period 1886-1912 (1401 male deaths, and 641 female deaths). For males the average previous duration of insurance was 6.8 years for cancer of the stomach and liver, 6.5 years for cancer of the peritoneum, intestines and rectum, 6.3 years for cancer of other organs or parts, 5.7 years for cancer of the skin, and 5.6 years for cancer of the buccal cavity. For females the average previous duration of insurance for cancer of the stomach and liver was 6.3 years, for cancer of the breast, 6.3 years; for cancer of other organs or parts, 5.7 years; for cancer of the skin, 5.6 years; for cancer of the peritoneum, intestines and rectum, 6.4 years; and for cancer of the generative organs, 5.2 years. tSome additional data on the subject of duration of cancer previous to death are given on page 115. 166 OBSERVATIONS AND CONCLUSIONS requires, therefore, to be determined with reference to biological con- siderations, and especially is this true in regard to the primary division of cancers into sarcomata and carcinomata. The former, which are much more common in early life, usually run a much more rapid course, whereas in some of the latter, particularly in very advanced ages, the duration of the disease may extend over a number of years. The statisti- cal aspects of this phase of the cancer problem have as yet received very inadequate consideration. It has been observed in this connection by Dr. C. Mansell Moullin, that Cancer is not a definite entity nor is sarcoma. The cancer of one organ differs from the cancer of every other organ, and the cancer of each individual person is as different from the cancer of all other individuals as his constitution is from theirs. . . . Sarcoma and carcinoma are artificial groups, not natural ones. It is not possible to define or limit either of them.* . . . The cancer of one organ is entirely different from the cancer of every other organ, and the clinical history of periosteal sarcoma varies with the bone to which the periostemn belongs. Each organ and each tissue has its own variety of malig- nant tumor, just as it has its own variety of innocent tumor, though the microscope may be unable to distinguish them, and the innocent tumors of each organ shade off by imper- ceptible stages into the malignant ones, so that together they form one group. No line can be drawn between them.f These observations reemphasize the earlier conclusions regarding the difficulties of a generally satisfactory tumor classification. If the point of view advanced by Dr. Moullin is sound, that "clinical characteristics are of no value for the classification of pathological growths such as tumors," and "whether a tumor is what we call malignant or not depends upon the degree of maturity already reached by the cell from which the tumor bud first branched off upon its independent career," there remains probably no other course in statistical procedure than to continue the present practice of an anatomical classification, which simply by reference to the organ or part of the body affected by malignant disease indicates with a high degree of accuracy the immediately important contributory circum- stance or condition responsible for the primary cancerous growth. The involved nature of the tumor problem presents so many interest- ing and important special problems that it would be utterly hopeless to meet the requirements of biological or pathological science by even the most refined methods of statistical analysis. For illustration, tumors have various shapes, or according to the division adopted by Delafield and Prudden, they may be nodular, tuberous, fungoid, polypoid, papillary, dendritic, lobulated, etc. They may occur singly or in greater or less numbers in the same or in different parts of the body. The degree of malignancy could probably never be successfully pre- sented by means of statistical data, even though derived from a large institutional experience. According to Delafield and Prudden, "The more obvious marks of malignancy in a tumor are: 1. Invasion of *The Lancet, March 21, 1914. t RELATIVE INCIDENCE OF CARCINOMA AND SARCOMA Total Deaths Deaths from Per from Cancer Sarcoma Cent. England and Wales ,_908-1912) 174,602 10,250 5.87 Scotland (1907-1911) 23,755 1,245 5.24 Ireland (1908-1912) 17,796 812 4.56 Norway (1908-1912) 11,461 580 5.06 Switzerland (1906-1910) 22,963 1,368 5.96 167 THE MORTALITY FROM CANCER adjacent tissues by eccentric or peripheral growth. 2. The tendency to local recurrence after removal. 3. The formation of metastases. 4. An interference with the nutrition and general well-being of the body, which may give rise to a condition known as cachexia." Here also the methods of statistical analysis must prove inadequate to the needs of the medical and surgical profession. Rapidity of Growth However involved these biological and pathological considerations of the cancer problem may be to the statistician, they can not be entirely ignored ; in fact, to a large extent the correct interpretation of statistical data depends upon a thorough understanding of the underlying ele- ments of the problem, which, if left out of consideration, may seriously, if not completely, invalidate the conclusions reached. In regard to the average duration of cancerous disease and the relative rapidity of growth of tumor tissue, it may not be inappropriate to include here the following interesting observation by Ritchie : Rapidity of Growth. — This varies very much in different cases. Sometimes, as in the case of many malignant connective-tissue tumors — e. g., those occurring in bone — the growth is extremely rapid, and in the course of a few months, or it may be weeks, the tumor may attain to such a size as to constitute a very definite proportion of the total body weight. In such a case, direct microscopic evidence of vegetative activity may be found in the abundance of mitotic figures observable in the cells. In other cases of malignant-tumor formation the growth is much more slow, this being exemplified in certain epithelial tvunors, say of the lip, and especially in some of the tumors liable to develop in connection with the intestinal mucous membrane. Here there! may be evidence of tumor formation being present for many months, in certain cases years, before any gross tumor results. Generally speaking, the connective-tissue tumors are those of most rapid growth, and the epithelial and hypoblastic tumors are the slowest. To the foregoing is added the following extremely interesting observa- tions by Hastings Gilford, from his treatise on "The Disorders of Post- Natal Growth and Development": Cancer varies greatly in its rate of extension. It may be so rapid as to simulate in- flammation. Indeed, quickly growing sarcomata accompanied by redness and pain have often been opened in mistake for abscesses. On the other hand, cancers are sometimes so slow in their progress that they make very little headway, even after they have been in existence for years, and are prone to be mistaken for fibromata. Their rate of growth is largely influenced by the surroundings. If adjacent cells be also more or less on the verge of degeneration, as in old age, the progress is, as a rule, very slow. If, on the other hand, the neighboring cells are engaged in the activity associated with progressive development, then the progress of the cancer is, as a rule, greatly accelerated. The difi^erence seems to depend upon the suitability of the environment. When the surroundings are congenial the progress is slow; when they are uncongenial the progress is rapid. It is, perhaps, never more rapid than when the cancer attacks the lactating breast, and never slower than when it forms in the useless senile breast, as the "stone cancer" of old women. All forms of cancer are more prone to appear in those organs which naturally undergo rapid changes, like the breast, and the glands in the cervix of the uterus, than in those which are comparatively stable in their development, like bone, cartilage, and muscle. Cancers show at times the peculiar feature of being temporarily delayed or stopped in their progress, and these phases of arrest or of increase may alternate more than once before the diseasa finally puts an end to existence. These observations are of much practical importance in connection with well-directed efforts to arouse public interest in the menace of cancer and the possibilities of cancer control. The problem of fundamental causation must for the time being be considered secondary in importance to the question of conditioning or 168 OBSERVATIONS AND CONCLUSIONS contributory circumstances favorable to the occurrence and develop- ment of malignant disease: for if even so simple a fact can be brought home to the laity that there is a material difference in the rate of malig- nant growth— whether sarcomata or carcinomata, whether among the young or among the old, whether among the strong and robust or among the anaemic and weak — much will have been gained in the direction of increasing the number of cases presenting themselves for early and qualified operative or other treatment. The public must understand that there are degrees of malignancy and that there is an increased probability of recurrence in the case of delayed operation. As a rule, "the less difiFerentiated the type of cell composing the tumor the more malignant it is," and "the small round-celled sarcoma is one of the most malignant types." Since the sarcomata are much more common to children and young persons, it is self-evident that the earliest possible qualified treatment is imperatively called for in such cases where the preliminary diagnosis warrants even the suspicion of a possibly malignant growth. "Experience," according to Montgomery, "has taught us to give a very unfavorable prognosis when cancer of the uterus appears prior to the age of 40. Possibly the hopeless outlook is in part due to the greater activity of the lymphatic system, the vessels of which de- crease in size and number with the advent of climacteric."* The age of the patient in cancer cases is always an element of im- portance in estimating the probabilities of successful treatment. Lock- wood in his treatise on "Cancer of the Breast," concludes that "a breast tumor in a young woman is more likely to be innocent than malignant." The average age of 43 women operated upon for innocent tumors was only 36.6 years, whereas the average age of 47 persons operated upon for carcinoma of the breast was 53.68 years. Clinical Signs There are apparently no absolutely conclusive clinical signs which can be relied upon for the correct diagnosis of tumors; but malignant disease, at least when fairly well advanced, is, as a rule, a cause of emaciation. Under the title of "General Debility, Pallor, Emaciation," Savill enumerates the symptoms of malignant disease to consist of (1) a loss of weight, which occurs quite early in the disease, sometimes long before any local signs can be detected. This is accompanied by a typical cachexia — i. e., an appearance of illness in which the skin assumes an ashy or sallow hue. (2) The age of the patient is generally advanced in carcinoma, young in sarcoma, and the four classical signs of the disease are pain, swelling, offensive discharge and haemorrhage. (3) Pain at the seat of growth is often complained of, especially in rapidly growing varieties, or when they occur in tense parts. (4) In accessible situations a thickening, swelling, or tumor may be detected, which is usually hard, nodular, and apt to fix and infiltrate the surrounding parts. Some sarcomata, however, are soft and pulsating. (5) Whenever the growth involves a mucous or epidermal surface there is an offensive pink or sero-sanguineous discharge. (6) In like manner haemorrhage may occur, and take the form either of metrorrhagia, coffee-ground vomiting, *Joumal of the American Medical Association, September 21, 1907. 169 TEE MORTALITY FROM CANCER or melsena; and when tlie disease involves the pleura or peritoneum the effused fluid will be blood-stained. (7) In carcinoma the neighboring lymphatic glands become enlarged and palpable. (8) The rate of growth is rapid, though it varies widely in different forms and localities. Scirrhous infiltration of orifices may only reach the thickness of half an inch in six to twelve months, and the patient may live two years ; but a round-celled sarcoma may reach the size of a hen's egg in a month or two and kill in six.* Anaexnia and Emaciation To much the same effect is the enumeration of symptoms by William- son in the fourth edition of French's "Practice of Medicine." With special reference to cancer of the stomach, it is held that There is great diversity in the symptoms of different cases. There may be no manifesta- ions by which the disease can be recognized untU comparatively late. The history of it that is generally obtained is indigestion during several months, increasing in severity, and attended ■nnth anemia and emaciation. , . . The early symptoms in an ordinary case are loss of appetite, impaired digestion, pain, nausea, and vomiting, f These usually develop so insidiously as to conceal the time of actual onset; rarely, however, they appear abruptly after an attack of influenza, or an acute indigestion. . . . Pain is a promi- nent sjTnptom in about three-fourths of the cases and often occurs early. It is usually confined to the epigastrium, but may be referred to the shoulders, sides or back. It is generally of a burning, gnawing, or dragging character; distinct cardialgia rarely occurs. It is generally constant, but increased by ingestion of food. . . . Anemia and , cachexia are often early symptoms and almost invariably present. The number of red corpuscles often sinks below 3,000,000, occasionally below 2,000,000, and the hemoglobin may fall below 50 per cent. . . . ^Tien the anemia is extreme there is often edema of the lower extremities and sometimes a more general dropsy. Emaciation often begins early, but in a large proportion of cases there is httle loss of weight until a late period of the disease. The degree of emaciation is often remarkable, the body being literally reduced to "skin and bones." The decline of strength usually keeps pace 'nith the loss of flesh, but a surprising degree of \-igor is sometimes retained to the end. J These extended references to the diagnosis of cancer are included pri- marily for the purpose of emphasizing the diflBculties of the statistical treatment of the more complex aspects of the cancer problem. They also have reference to the question of accuracy and completeness in death certification; but it is necessary to keep in mind that the initial diagnosis is naturally much more diflScult than the terminal diagnosis, when, at least to the trained physician, the manifestations of the disease are readily apparent. Prognosis of Cancer The prognosis of cancer, particularly in cases where the treatment has been delayed, is, according to Savill, "always of the gravest kind, the course rarely lasting more than one, or at the outside, two years. . . . The prognosis largely depends upon the stage at which the true nature of the case is detected. On this depends very largely both the •Sa^Tll, "System of Clinical Medicine," New York, 1912, 3d edit., p. 588. f'Cancers vary much. Some, for instance those of the skin or lip, cause no anamia, while a fulminating cancer, as of the stomach, may give a perfect picture of preliminary pernicious anemia, or, indeed, of leuksemia. In general it is stated that the more malignant the tumor the greater the blood changes, and the more extensive the cancer, that is, the more its metastases, the greater its influence upon the blood. But this is not entirely true: our cases with rapidly developing metastases, with large nodules, are those with a slight chlorotic ansemia; those which simulate pernicious ansemia are more often cases with few if any objective signs of cancer, and at autopsy one finds an insignificant looking little nodule." (Emerson's "Clinical Diagnosis," p. 636.) JFrench, "Practice of Mediciae," 4th edit., pp. 773-776. 170 OBSERVATIONS AND CONCLUSIONS prospect of arrest and of removal. In general terms the prognosis also depends on (1) the position and accessibility of the growth, how far vital structures are involved, and whether it is on or near the surface; (2) the structure of the tumor; and (3) the age of the patient, to some extent, for growth is more rapid in the young."* These observations have an important bearing upon the problem of cancer control. At the present time the percentage of cases suc- cessfully treated is relatively small, as made evident by the con- siderable annual mortality from malignant disease throughout the civilized world. The available evidence is entirely conclusive that by early diagnosis and prompt, radical treatment, a fair proportion of the lives now lost could be saved or prolonged for many years. As pointed out by Bloodgood, "The clinical symptoms of cancer of the uterus are so distinct that it should not be difficult to educate patients and the profession, but unfortunately, even at present, the percentage of patients with cancer of the uterus seeking expert surgical advice in the inoperable group is still large," and he points out further in this connection that "if it has been difficult to educate people and the profession as to the potential danger of a lump in the breast, small and painless defects of the skin and mucous membranes and irregular bleeding from the uterus, it will be much more difficult to educate them to the significance of abdominal pain, indigestion and changes in the stools." He therefore concludes that the control of cancer is a problem of education, and that those clinics which have the records, the pathological proofs, must work up their statistics so that we may increase our evidence in support of the statement that cancer has been cured. f Heredity Such a process of education will not be an easy matter. There are deep-rooted convictions which will have to be overcome by the accumu- lation of indisputable evidence, which must be largely obtained by means of qualified statistical research. There is still a wide-spread belief that cancer is a blood disease, frequently inherited, possibly contracted by infection, and in any event, extremely difficult to cure or control by medical or surgical means. The apprehensions of members of families in which one or more cases of cancer have occurred are in obvious contra- diction to the available evidence that cancer is not inherited in the strict sense of the term, and that the probability of an inheritance of a predis- position to cancer is relatively remote and decidedly less than in tuberculosis . The evidence brought together on this point in the chapter on the relation of the cancer problem to life insurance fully sustains the conclusion that the available facts are largely of a negative kind. The conclusion advanced by Rudolph Schmidt, that "many an ancestral tree that has been studied, scarcely leaves room for doubting the possibility of direct transmission," is not sustained by the required statistical evidence, in other words, by a sufficient number of authentic cases, to re- move the margin of reasonable doubt as regards the occurrence of mere coincidence or the influence of collateral factors, such as an inherited *Savill, "System of Clinical Medicine," New York, 1912, 3d edit., p. 589. ^Journal of the American Medical Association, December 27, 1913. 171 THE MORTALITY FROM CANCER exceptional longevity on the part of the parents and their offspring from a long line of long-lived ancestors, or the continuity of almost identical habits and modes of life more or less in the nature of predisposing causes. Thus, for illustration, it is possible that the drinking-water of a community may act as a chemical irritant and as such have a strong influence upon the body fluids, as is apparently the case in endemic goitre. Family History The number of separate and distinct factors which condition the rela- tive frequency of cancer among the different types of mankind entirely preclude the possibility of any one of them being of predominating impor- tance. The researches of Karl Pearson, including the family history of some 3,000 cancerous persons and a comparative study of the same number of non-cancerous patients, appear to establish the conclusion that "there was practically no difference between them in respect to the prevalence of the disease among their relatives." This conclusion is further sustained by the collective experience of American life insurance companies and the less extensive experience of The Prudential. Bash- ford, in a well -written argument on "Heredity and Disease" presented to the Royal Society of Medicine, remarks that "Taking the surface of the body as an example, the incidence of cancer in different races of mankind is characterized, on the whole, not so much by innate racial peculiarities as determined by extrinsic irritants. Why some indi- viduals escape the consequence of peculiar practices involving chronic irritation, and others do not, it is at present impossible to decide. Dis- regarding all other hypotheses, we fall back on an undefined suscepti- bility of the body, which we conceive as being more exaggerated in some persons than in others. There is certainly no evidence for the inheri- tance of cancer as such — only the possibility of a predisposition can be discussed." Bashford refers to an interesting paper by W. Harrison Cripps on "The Relative Frequency with Which Cancer is Found in the Direct Offspring of a Cancerous or Non-cancerous Parent," using in addition the data presented by Dr. Ogle in the Fifty-second Annual Report of the Registrar-General of England and Wales. He pro- vides the required statistical evidence that "When no hereditary influence is assumed, the frequency of cancer as a cause of death is so great that few families of large size escape; and in one of every two families either a parent or a grandparent will, on an average, have died of cancer, supposing such parents and grandparents to have died after 35 years of age," or in other words, "The mor- tality from cancer is so great that, on an average, in one of two families either a parent or a grandparent will have died of cancer without assuming hereditary predisposition. Hence the use made of such records to prove the occurrence of a large number of cases of cancer in a selected number of families is not warranted." There are few more interesting directions in which qualified statis- tical research could aid the scientific study of the cancer problem than by an extended analysis of authentic family records over a long period of years. Unfortunately such records are extremely difficult to secure, and it is practically impossible to give due weight to all the other factors 172 OBSERVATIONS AND CONCLUSIONS and conditions likely to determine the rare or excessive incidence of cancer met with in exceptional families for which the data concerning cancer may be available.* Cancer Heredity in Mice The experiments on animals which have been made under the direc- tion of cancer research funds seem to establish that a predisposition to cancer can be developed under given conditions ; but it is not at all likely that the artificial laboratory conditions are ever experienced in actual life, in which the factor of variation is enormous. Prof. Tyzzer, of Harvard, has investigated the life history of a family of mice consisting of 100 individuals, of which a post-mortem examination was made imme- diately after death. Even this number of cases, in the opinion of the author, was too small for final conclusions, but as observed by Murray in an editorial in the British Medical Journal, "The figures are certainly striking, and it is not improbable that the modern view that heredity has but little influence in regard to susceptibility to cancer may require to be modified as a result of experimental research." Miss MaudSlyeof the Sprague Memorial Institute of Chicago has made two reports upon the incidence and inheritability of spontaneous tumors in mice, including observations on 390 cases. The conclusions of Miss Slye are summed up in the brief statement that "Cancer is probably possible in any mouse, but it is likely to occur where heredity predetermines," or in other words, "Heredity determines in which cases it shall develop into a malignant cancer." In another paper by the same author the statement is made that "Hereditary influences show a marked relation to the occurrence and character of lung tumors. Of 155 cases investigated from this standpoint there was a tumor ancestry in 146, and in but 9 of the cases lung tumor appeared in the mice without tumor ancestry." It must be seriously questioned whether these conclusions are practi- cally applicable to the consideration of cancer as a human problem. The conditions under which human beings grow and develop, persist and survive, are fundamentally different from those which affect animal life. The factors of deliberate control and the enormous power of adaptability to changing environmental conditions utterly preclude the possibility of the unrestrained effect of possible hereditary tendencies towards particular diseases, especially cancer, which, as a rule, occurs very late in life, when the degree of bodily resistance, on the one hand, and the effect of special habits of life, on the other, have become well estab- lished and assumed a power equivalent to direction and control. The same analogy, which would reduce the human body to the mechanism of a machine, breaks down in the case of cancer theories which would make the human organism conform in its conscious or subconscious development to the elementary and non-intelligible mode of animal life. In other words, granting the possibility of direct inlieritance of a *"Given a sufficient number of families, it is a certainty, even if there be no such thing as heredity, that of at least one family, say ten members will die of cancer. The only absolute proof of heredity would be to show that cancer occurred frequently in certain families, and practically nowhere else; short of this the probability of heredity of cancer would be increased if it could be shown that cancer was much more common in certain families than in the average for the whole community, due allowance being made for variations in age and sex- distribution." (Newsholme's "Elements of Vital Statistics," p. 201, quoted in the George Crocker Special Research Fund Publication, Vol. i). 173 TEE MORTALITY FROM CANCER predisposition to cancer, the numerous external factors of every-day life, of years of self -directed effort, of changes in habits, climate, food, etc., all preclude, excepting possibly in the rarest cases, a predetermined occurrence of cancer in the offspring of a cancerous parent under the normal conditions of human existence. The discussion on the subject of heredity in cancer, with special reference to the laboratory evidence of such a transmission in the case of mice, is summed up by the Journal of the American Medical Association in the statement that "the liahility is the thing transmitted, but without appropriate conditions the effect is not produced ; that is, heredity modifies the character or degree of the effect produced by a common injury," which leaves us much in the same position as before. The appropriate conditions do not repeat them- selves in the normal human life; but if cancer is the result of local ir- ritants, then any and all factors which contribute towards this end must have their influence, although a single factor under given conditions, as in Kangri cancer or X-ray dermatitis, may be so self-evident as to preclude the possibility of collateral or contributory causes or con- ditions. In any event, the available evidence, statistical or otherwise, does not sustain the conclusion that the factor of human heredity is of much material importance, individually or collectively considered. Cancer and Ovemutrition The evidence is decidedly more conclusive that there is a direct rela- tion between malnutrition or ovemutrition and cancer frequency. The relation of diet to cancer has been discussed in some detail by Dr. L. D. Bulkley of New York, who, after referring to the question as to whether there is not some deeper fundamental cause lying back of the trouble which should be reached and rectified by medical skill and acumen, observes that "It is recognized by aU that the tissues develop and are maintained by nutrition derived from the food and drink taken, and tumors all certainly grow by the same means. For years it has been claimed by one person or another that diet has more or less influence in the production of cancer, and even over one hundred years ago, Howard Lambe and others produced strong proof to show the effect of diet in curing certain undoubted cases of cancer of the uterus, the diagnosis of which was confirmed by prominent surgeons of the day." Even earlier than this Johann Philip Berchelmann, in a treatise pubHshed in Frankfurt a/M., 1764, attributed cancer to the acid and corrosive deterioration of the lymphatic glands caused by the excess of hard, common acid or acid and fatty sulphuric substances con- tained in food and drink, including brandy, cider, etc. He also men- tioned specifically the danger of an excess in a fish diet, particularly trout and eel, as well as oysters, bread, macaroni and pork. The importance of these early references lies in the recognition of the etio- logical significance of protein excess in diet, which was subsequently accepted by other WT-iters, particularly Michel, Dunn, Williams, and others.* B. F. Glinsburg, as early as 1853, held that the conditions responsible for corpulence were the same as those in carcinoma. In each of these he attributed the abnormahties of the metabolism to the excess of an albuminoid diet. *J. Wolff, "Lehre von der Krebskrankheit," Jena, 1911, Vol. ii, p. 84. 174 OBSERVATIONS AND CONCLUSIONS Cancer and Metabolic Disorders The statistical correlation of variations in cancer frequency and errors and defects in the physiological economy of nutrition would be extremely difficult, if at all possible. The physiology of metabolism, regardless of a truly enormous amount of literature, is as yet far from having reached the position of an exact science. The term metabolism has been defined as "the collective chemical changes taking place in living matter. When these metabolic changes are constructive, as in the building up of tissue protoplasm from the absorbed food material, they are termed anabolic; when they are destructive, as in the breaking down of living matter, or in the decomposition of materials stored up in tissues and organs, they are termed katabolic." As further explained by Prof. Chittenden: "Proteid metabolism, or more exactly proteid katabolism, therefore, means the destructive decomposition of proteid or albuminous matter in the living body and is pratically synonymous with nitrogenous metabohsm, since the entire nitrogen income is mainly supplied by the proteids or albuminous matters of the food.* Based up.on more general considerations the opinion has frequently been advanced by ancient and modern writers that there is a direct relation between diet and cancer frequency, and particularly has this been claimed to be the case in regard to the excessive consumption of salt and meat. The per capita rise in the meat consumption of the principal civilized countries has been referred to as a causative factor in the corresponding rise in the cancer death rate. The statistical evidence, however, of a precise correlation of cancer frequency to per capita meat consumption or its relative infrequency or rarity among vegetarians has not been established. As well said in an editorial in the New York Evening Post of July 1, 1914, "Admitting that meat eating in England has doubled during the last fifty years, there are a number of other changes quite as vital that have taken place in the same interval, and it would be the height of rashness to assume that this particular change was the determining factor." This argument is quite conclusive, since, as frequently pointed out, the precise correlation of any single factor to cancer frequency is extremely difficult, with the exception of such unusual forms of malignant disease as Kangri cancer, chimney- sweeps' cancer. X-ray dermatitis, etc. Vegetarianism The relation of vegetarianism to cancer frequency has been reported upon in considerable detail by W. R. WilHams, in his treatise on "The Natural History of Cancer."t He observes that "It may be well to recall the fact that although cancer is remarkably rare in vegetarian communities, yet complete exemption cannot be claimed for such; and the like is true of herbivorous as compared with carnivorous." He, however, is convinced by overwhelming evidence "that the incidence of cancer is largely conditioned by nutrition." Investigations along this line of inquiry should be made with a due regard to the organ or part of the body affected. Nutrition is not likely to have any relation whatever to the occurrence of Kangri cancer or chimney- *Chittenden, "Physiological Economy in Nutrition," p. 1. tW. R. Williams, "The Natural History of Cancer," p. 350. 175 13 TEE MORTALITY FROM CANCER sweeps' cancer, but there is quite probably a determinable relation between gastric cancer and serious errors in nutrition and metabolism. Von Noorden holds "That a purely vegetable diet is not of advantage to the majority of mankind does not depend on any peculiar difference between the protein of plant and that of animal origin, but is the result rather of the presence of smaller quantities of protein in vegetable food, and an unequal and unsuitable distribution of the other important food stuffs present, as well as of certain mechanical intestinal disturbances which are often associated with a diet of entirely vegetable origin."* With special reference to the inffuence of cancer upon the digestive processes. Von Noorden mentions the investigations of Van der Velden pro^dng the absence of free HCl in cases of cancer of the stomach, and the confirmation of this statement by many subsequent observers and its general acceptance at the present time as one of the most .assured facts in the pathology of the diseases of the stomach. He points out that there are chemical changes in the gastric contents which result from the action of the products secreted by the new growth; that on the basis of a very extended series of observations it was shown that there was a marked diminution in the secretion of hydrochloric acid. "But," as he observes, "the question whether the development of cancer has any influence on intestinal digestion has never been closely and com- prehensively studied, because the specific influence on the functions of the intestine, similar to that which has been believed to exist in the case of the gastric juice, had never been observed or asserted." "Clinical experience," he remarks, ."teaches that cancer of the stomach is not necessarily followed by any intestinal .disturbances, not even when characteristic changes of the gastric functions, such as a deficiency in HCl, a slight disturbance of the motility of the stomach, or again, a f orma- tion»of lactic acid, could be clearly demonstrated." With reference to the development of cancer in the duodenum, in the gall-bladder, in the liver or in the pancreas. Von Noorden is of the opinion that these may be considered to be the cause of disorders of the biliary or pan- creatic secretion. t Upon the important question as to the effect of the development of cancer upon the blood, b'S remarks that "During the development of cancer the blood frequently undergoes changes which manifest themselves clinically as a more or less severe ansemia. Here again it is especially cancer of the stomach that is associated with *Von Noorden, "Metabolism and Practical Medicine," Vol. i, p. 3. tFor some extremely suggestive observations and conclusions on the relation of diet to cancer frequency under experimental conditions, see the paper on "The Rate of Tumor Growth in Under-Fed Hosts," by Peyton Rous, Proceedings of the Society for Experimental Biology and Medicine, May 17, 1911. Also, address on "The Relation of Diets and of Castration to the Transmissible Tumors of Rats and Mice," by J. E. Sweet, EUen P. Corson- White and G. J. Saxon, from Journal of Biological Chemistry, July, 1913, and "The Influence of Diet on Transplanted and Spontaneous Mouse Tumors," by Peyton Rous, Journal of Experimental Medi- cine, No. 5, 1914. Rous observes that the experimental evidence "shows that the development of tumor grafts can in many cases be prevented or retarded by underfeeding the host or by putting it on a special diet." Corson-White and her associates conclude that "the unfavorable influence of poor nutrition (on cancer growth) as brought about by intercurrent disease upon the rate of growth of the transplanted tumor is a matter of general observation." They refer to the work of Mendel and Osborne, "who found in their studies of the effects of feeding rats with combinations of pure vegetable proteins a number of diets which completely retarded the normal growth of the animal, although the general condition seemed entirely normal," and they say that, "in other words, their animals were not starved in any sense except a very specific one — certain elements necessary to normal growth were lacking." The implication of these experiments is of far-reaching practical importance. They prove at least as regards rats and mice under expected condition that the susceptibility to transplantable tumors may be influenced loth positively and negatively by proper diets, and the same conclusion applies to the rate of growth as well as to initial susceptibility. 176 OBSERVATIONS AND CONCLUSIONS anaemia, while cancer of the uterus and other internal organs come next in order." He remarks, however, that "Though the anaemia is by no means a constant symptom of the growth of cancer, some investigators insist on its being a specific effect of the hypothetical cancer toxin,"* Diet and Cancer Frequency These extremely involved biochemical aspects of the cancer problem are largely outside of the field of statistical research. The value of the evidence, of course, is proportionate to the number of cases considered, and this is particularly true with respect to the comparative frequency of cancer among meat-eating and vegetarian races. In the discussion of the experience data of life insurance companies the fact was brought out that the proportion of deaths from cancer among Mohammedans in the experience of the Oriental Life Insurance Company of Bombay had been practically negligible, whereas among Europeans the pro- portionate mortality from this cause was 3.93 per cent. Williams, on the basis of a world-survey, came to the conclusion that the cancer death rate was invariably very low among people predominantly poor, of necessity very frugal, subsisting on an alimentation comprising but little proteid food. "A remarkable negative feature of reports regarding cancer frequency in India," according to the same authority, "is the almost complete absence from them of cases of malignant disease of the stomach (pylorus) ; and an equally noteworthy positive feature is the un- usually great predominance of external cancers," particularly of the male generative organs. Out of 1,589 cases of cancer reported from India and analysed by the Imperial Cancer Research Fund, 1,513 involved the external surface of the body, and only 76, internal organs. The rarity of malignant tumors in India has been confirmed by the researches of liConard Rogers, on the basis of an exhaustive study of the Calcutta post-mortem records. He found that malignant tumors cause only 2.9 per cent, of the deaths from all causes, or a very small proportion compared with European experience, partly accounted for by the low- age incidence of the subjects. Out of 1,000 autopsies, only 1 was a case of cancer of the stomach; 2, of the large bowel; 4, primary cancer of the liver; 3, primary cancer of the gall-bladder; 1, of the bile-duct; 4, of the pancreas, and 1, of the fallopian tube. All the diagnoses were verified microscopically. The data relate only to post-mortems, but it is pointed out by Rogers that cancer is also comparatively rare in the surgical series. Out of 396 cases of carcinoma, in the experience of the Mayo Hospital, in Lahore, during the decade 1892-1903 (270 males and 126 females) 72 were cancers of the male generative organ (all Hindoos) ; 58, of the skin ; 50, of the breast ; 30, of the rectum ; 23, of the uterus ; 23, of the liver ; 20, of the tongue; 13, of lip, cheek, mouth, and palate; 6, of the bladder; 5, of the pharynx; 5, of the larynx, etc. There was not a single case of malignant disease of the stomach in this apparently well-observed experience, t *Von Noorden, "Metabolism and Practical Medicine," Vol. iii, pp. 797-805. tW. R. Williams, "The Natural History of Cancer," pp. 34-35. 177 THE MORTALITY FROM CANCER Influence of Civilization The available evidence would seem to support the conclusion that malignant disease of the stomach is relatively much less frequent among non-flesh-eating races than among those not confined to a vegetarian diet. Bulkley, reporting the results of his studies during a rather extensive trip through the far East, states that although he met a large number of medical men and made personal inquiries at hospitals with a total of many thousands of patients, in Japan, Corea, China, Philippines, Siam and Egj^pt, he met everywhere with the same response: "Cancer was rarely seen among vegetarian peoples." This rather sweeping conclu- sion will hardly' hold in regard to external cancers, or internal cancers other than those of the stomach and organs and parts directly related to the processes of nutrition. Bulkley, in a notable paper on "The Relation of Diet to Cancer," holds that "with advancing civilization the diet has become more and more complicated and luxury and over-eating have increased: this is especially true of meat-eating and alcohol and coffee drinking. . . . Among the well-to-do the meat consumption has been estimated at between 180 and 330 pounds per year. Already this is much more than double the amount consumed fifty years ago, and in the same time the deaths from cancer have increased over fourfold."* If meat-eating, as such, were a direct cause of cancer frequency, it would seem reasonable to suppose that the disease should be exceptionally common among certain tribes of North American Indians who, to an unusual extent, five upon a meat diet. As a matter of fact, cancer is apparently very rare among North American Indians, at least as far as ascertainable through the records of the Division of Vital Statistics of the United States Census. In the year 1910 there were 886 deaths of Indians, more or less of mixed blood, reported for the registration area, and of this total only 9, or 1.02 per cent., were deaths from cancer or other malignant tumors. Of this number 6 were cancers of the stomach and liver, or 66.6 per cent, of the whole. In contrast, out of 1,055 deaths from all causes among Chinese in the United States registration area in the year 1910, 44 were deaths from cancer and other malignant tumors, and of this number 19, or 43.2 per cent., were deaths from cancer of the stomach and liver. These data are confirmed by the investigation of the George Crocker Special Research Fund. It must be considered extremely doubtful whether the operation of any single factor is sufficient to induce an excess in the normal frequency of cancer among human beings, even though the evidence may be quite conclusive that such a factor operates as a main contributory or accelerat- ing condition. Overeating and, even more, overnutrition are unquestion- ably most important contributory causes in cancer occurrence. The principle of the physiological economy of nutrition has been admirably set forth by Prof. Chittenden in the statement that There is no question, in \-iew of our results, that people ordinarily consume much more food than there is any real physiological necessity for, and it is more than probable that this excess of food is in the long run detrimental to health, weakening rather than strengthening the body, and defeating the very objects aimed at. . . . Physiological economy in nutrition means temperance, and not prohibition. It means full freedom of *Bulkley's observations and conclusions on the metabolism of cancer and the relation of cancer to diet have recently been published under the title "Cancer — Its Cause and Treatment," New York, 1915. 178 OBSERVATIONS AND CONCLUSIONS choice in the selection of food. It is not cereal diet nor vegetarianism, but it is in the judicious application of scientific truth to the art of living, in which man is called upon to apply to himself that same care and judgment in the protection of his bodily machinery that he applies to the mechanical products of his skill and creative power.* Theory of Atra Bills The possible biochemical causes of cancer have not as yet been suf- ficiently investigated to justify more than very general conclusions. The statement by F. W, Forbes Ross, that "so far as my researches on epithelial cancer have taken me, I have reason to believe that the dis- turbance of the potassium balance in the body is the cause, or one of the main causes, of epithelial cancer" is justified as a hypothesis, but not as a final conclusion. An equally interesting and possibly more conclusive observation in this connection has been made by E. F. Wright in his treatise on "Plant Disease and Its Relation to Animal Life": "It is clearly proved that there is a great difference in the composition of a healthy or normal bile and of the bile of one suffering from cancer." This conclusion, if sound, would go far to confirm the ancient theory of atra bilis, or the production of black bile by the renal and suprarenal glands, and its effect on temperament and predisposition to generate tumors of all kinds. The theory of black bile as a cause of cancer, which prevailed as a dogma until far into the eighteenth century, was a mere fancy of the imagination; but the theory that an abnormal condition of the bile may, under given conditions, be due to cancerous processes rests upon the substantial ground of precisely determined evidence.t Biochemical Aspects It is in the direction of qualified and special research of the con- tributory factors in nutritional disturbances and their relation to can- cerous processes that the most valuable results of cancer research are likely to be had. If, for illustration, the theory of Ross is true, that the artificial or intentional regulation of the potassium balance in an apparently hopeless case of cancer will affect a profound change for the better in the disease, it is self-evident that such a hypothesis is entitled to much weight. The main object in all cancer research is the ascertainment of the whole truth of the cancer problem; but it is also important, and primarily so, to determine the factors or processes contributory, on the one hand, to an increase in the cancer death rate, and to the control of cancerous conditions, on the other. The conclusion, however, by the same writer that the relative cancer death rates of England and Japan negative the theory of the influence of a vegetarian diet and cancer frequency is untenable, because of the fact elsewhere discussed that the mortality by organs and parts varies considerably in the two countries. For illustration, the average death rate for cancer of the stomach was 31.4 per 100,000 of population for England and Wales, 1906-10, against 40.0 for the Empire of Japan, 1909-10. In contrast, the mortality from cancer of the breast was 17.9 per 100,000 of women in England and Wales, against 1.8 for Japan. *Chittenden, "Physiological Economy in Nutrition," pp. 474-475. tPor a full discussion of the theory of atra bilis, see J, Wolff, "Lehre von der Krebskrankheit," Jena, 1907, Vol. i, pp. 1-53. 179 THE MORTALITY FROM CANCER Exophthalmic Goitre A brief consideration seems here called for of goitre and its possible relation to the cancer problem. Goitre is an enlargement, particularly if hypertrophic, of the thyroid gland. Anaemic, or exophthalmic goitre, is a disease characterized by cardiac palpitation, tremor and a high pulse. The disease is more common among women than among men. The etiology is obscure. According to Gould and Pyle, there are three theories for the occurrence of exophthalmic goitre: 1, the cardio-vascnlar, 2, the mechanical, 3, the nervous. None of these explain the occurrence of endemic goitre, the etiology of which was reported upon in the Milroy Lectures, delivered at the Royal College of Physicians of London, 1913, by Robert McCarrison of the India Medical Service. This distin- guished author examined minutely the nature of the goitrigenous agency in water and the source from which the same was derived. He con- sidered the geological structure of the soil and its relationship to goitre, but he came to negative conclusions, to the effect that while the occur- rence of goitre was very much more commonly associated with lime- stone and dolomite formations and with marine deposits generally, this association was not a constant one; for not only were these formations often entirely free from the disease, but goitre could and did prevail on almost every other geological formation, from the most ancient to the most modern. He was unable, also, to establish a correlation be- tween the amount of any single dissolved ingredient in the water of goitrous communities that could De detected by chemical tests. He was willing to concede that hard water might favor the action of the goitrigenous agency, but he held that such waters were not capable by virtue of their hardness alone of causing goitre. In regard to radio- active substances in the waters of goitrous communities, he refers to the researches of Repin, and the conclusion that "These waters exercise on the general metabolism a powerful action of which the thyroid hyper- trophy is the only reverberation." He quotes the same authority to the effect: "That goitrigenous water is invariably mineral water; that in this water exists some chemical ingredient — ^possibly salts of lime and magnesium, possibly radio-active substances— which is the active principle in the production of goitre." This view was not accepted by McCarrison, particularly on the ground of the researches of the Swiss Goitre Commission, which prove that "Goitrous waters almost invariably showed an infinitely higher bacterial content than innocuous waters," and the fact that in radio-active waters the bacterial content was low. Without enlarging upon the extremely technical aspects of the etiology of endemic goitre, it appears that the conclusion of McCarrison, based upon and sustained by the findings of the Swiss Goitre Commission, is that "Goitre-producing waters are eminently those in which micro-organisms find the nutrient materials for their life and growth." Endemic Goitre in Fish The importance of these considerations are emphasized in the value attached to the investigations by Gaylord and others, in cooperation with the United States Fish Commission, into the occurrence of endemic goitre, or more accurately, thyroid carcinoma among artificially bred 180 OBSERVATIONS AND CONCLUSIONS trout. McCarrison refers to the investigation by Marine and Lenhart, stating that "Overfeeding, overcrowding, and a hmited water-supply, are the major factors in the production of filthy, unhygienic tanks or ponds, and the unsanitary, unhygienic and filthy tanks are in a very important but still unknown manner associated with the development of thyroid hyperplasia." Gaylord's observations were found to be in complete agreement with the findings of Marine and Lenhart. A table is given showing the increase in the prevalence of the disease from non- occurrence in the upper tanks to 3 per cent, goitrous in the first tank, 8 per cent, in the second, 45 per cent, in the third, and 84 per cent, in the fourth. These interesting results are further confirmed by the goitre investigations in the villages of Gilgit, India, made bj'' McCar- rison in 1905. In that case, there was "the same increased prevalence of the disease as the water became more polluted, and a diminution in the amount of the disease as a result of dilution of the impure water with fresh spring water." The markedly place-character of the disease, even in the case of trout, was therefore well illustrated. Marine and Lenhart had arrived at the conclusion, as a result of their observations, that goitre was "the symptomatic manifestation of a metabolic and nutritional disturbance, and that food was the major factor acting to bring about a fault of nutrition favorable for goitre development." This conclusion was not accepted by McCarrison, who considered it inconsistent with some of the facts and opposed to the theory advanced by him of a micro-organism as a satisfactory explanation of the develop- ment of the disease in artificially bred trout. Thyroid Carcinoma* Gaylord and Marsh of the New York State Institute for the Study of Malignant Disease, in an elaborate report on "Carcinoma of the Thyroid in Salmonoid Fishes," published by the United States Bureau of Fisheries, 1914, conclude that "The disease known as thyroid tumor, endemic goitre, or carcinoma of the thyroid in the Salmonidae, is a malig- nant neoplasm ; that it occurs in fish living under conditions of freedom in populated areas; that when introduced into fish-breeding establishments it becomes endemic, with occasional epidemic outbreaks; that normal fish taken from the wilderness may be made to acquire the disease when placed in fish-breeding establishments where the disease is endemic; that the feeding of uncooked animal proteid favors and the feeding of cooked animal proteid retards the disease as compared with the uncooked; but that feeding alone is not an efiicient cause." They therefore hold that "There must be a transmitting agent, probably through the water or food, or both," and that "By scraping the inner surface of water- soaked wooden troughs in which the disease was endemic, they secured an agent which from its action upon the mammalian thyroid when ad- ministered through drinking water was no doubt the cause of the dis- ease in the fish confined in these troughs." They found that the agent The mortality from goitre in the United States Registration Area is 14.1 per 1 ,000,000 of population (1910-13) . For males the rate was 3.0, and for females 25.8. For England and Wales (1911-12) the rate was 11.4 per 1,000,000 for both sexes combined; 2.1 for males, and 20.1 for females. For the Eastern States in the United States Registration Area the goitre mortality rate was 11.3; for the Southern States, 6.1 ; for the Central States, 20.2; for the Rocky Mountain States, 10.6; and for the Pacific Coast States, 12.4. The highest rates prevailed in an almost contiguous area, as follows: Michigan, 24.9, Indiana, 22.0, Ohio, 21.2, Wisconsin, 18.6, and Minnesota, 18.1. All of these rates are decidedly above the average for the registration area as a whole. 181 THE MORTALITY FROM CANCER could be destroyed by boiling, and that fish in all stages of the disease were favorably affected in the direction of cure by the addition to the water supply in suitable concentration of mercury, arsenic or iodine. They therefore advance the very important general conclusion that the effect of mercury, arsenic and iodine in carcinoma of the thyroid in fish and the subsequent positive experiments with metals in mammalian cancer are probably the expression of a therapeutic relation of these elements to carcinoma. They found that certain species of the Sal- monidae had an almost complete natural resistance to the disease, and that certain lots of fish of susceptible species show a high degree of immunity to the disease; that spontaneous recovery occurs in a con- siderable percentage of individuals; that removal from ponds in which the disease is endemic to natural conditions or a change to more natural food increases the percentage of spontaneous recoveries; and that such a recovery appeared to confer a degree of immunity against recurrence.* Following these extremely interesting and apparently thoroughly scien- tific investigations and conclusions, the authors maintain that the disease known as endemic goitre, or carcinoma of the thyroid, is endemic in a very high percentage of all trout hatcheries in the United States, and that "The occurrence of the disease in wild fish, its introduction into fish-cultural stations, its localization in certain troughs or water sup- plies, the method of its spread, its transmission to mammals, the efficacy of certain well-known inorganic germicides in the treatment of the dis- ease, the destruction of the agent by boiling, the phenomena of the spontaneous recovery and immunity, strongly indicate that the agent causing the disease is a living organism." But they add, "No evidence has yet been produced to indicate the direct transmission of the disease from individual to individual."t It has seemed advisable to add the foregoing rather extended observa- tions on goitre in human beings and in the salmonoid fishes as an exceptionally interesting contribution to the theory that cancer and allied diseases are primarily conditioned by errors or defects in nutrition and metabolism, and that, therefore, the underlying principal cause of cancer frequency is a wide departure in modern life from the normal mode typical of primitive races, among whom, as far as known, cancer is in all of its forms of comparatively rare occurrence. A full dis- cussion of this phase of the cancer problem does not come within the scope and plan of the present work. There is, however, an obvious possibility that statistical research, particularly in the direction of determining with precision the local geographical incidence of the dis- ease and its direct correlation to the more important contributory factors, but especially to the diet and nutrition of the population affected, *Bulletiii of the U. S. Bureau of Fisheries, Carcinoma of the Thyroid in Salmonoid Fishes, p. 506. fThe subject of thyroid carcinoma and the cause of goitre in fish are briefly referred to in the Cancer Studies by the George Crocker Special Cancer Research Fund, Vol. i, pp. 242-243, as follows: "There are no evidences that the disorder was either infectious or contagious, but much in favor of the view that it was the symptomatic manifestation of a metabolic and nutritional disturbance. . . . Limited water supply, overcrowding, and overfeeding with a higlily artificial and incomplete food. The water of the hatchery was not intrinsically goitre- producing, because fish would not develop the disease unless at least the factor of overfeeding with an incomplete food were in operation, and because they recovered if the overfeeding and overcrowding were corrected, even though remaining in the same pond. Therefore it seemed probable that food was the major factor in bringing about some fault of nutrition favorable to goitre development, although it was impossible to suggest whet elements in the diet were implicated." 182 OBSERJ^TIONS AND CONCLUSIONS may prove of great practical value in the ascertainment of the specific factors or conditions chiefly responsible for an excess in cancer frequency in particular localities. , ^, Cancer and Obesity The evidence elsewhere introduced in this work regarding the cor- relation of overweight to cancer frequency is as yet inconclusive. As a single factor the importance of overweight in relation to cancer can easily be exaggerated. Obesity is, broadly speaking, "an excessive development of fat throughout the body, and it usually occurs after the prime of life, but it may be congenital, or may occur at any period of life." "Oljesity," according to French's "Practice of Medicine," "is the peculiar state of body in which, probably as a result of abnormal nutri- tion, there is an excessive accumulation of adipose tissue. . . . The principal causes that lead to it jare excess of food and drink, especially of starches, sugars and malt liquors, with deficient exercise, yet many fleshy persons are remarkably abstemious and some are overcome with fat in the midst of an active life." Overfeeding is here confused with malnutrition, which is not the exact equivalent of overnutrition. Rabagliati emphasizes the importance of connective-tissue con- gestion and the relation, therefore, of cancer to rheumatism. He holds that wrong alimentation gains power as age advances, and that the increasing weight of authority is in favor of the view that cancer is a food disease. He brings out the important point that the reason why cancer is rare in childhood and early life is because the irritation of the organism is accompanied by intolerance and followed by infectious fevers and inflammation, whereas in middle life "the organism being weighed down and oppressed by the excessive load it is compelled to carry, and the tissues being somewhat resistant, it does not intolerantly react against the irritation into a high fever, but on the other hand is simply depressed by it." He explains why cancer becomes less com- mon over 65 years of age by holding that "persons by that time have learned how to live, and those who have not learned or who would not learn have been swept away by some of the chronic, or by some of the acute illnesses." His final conclusion is that "Too many meals, and especially when they contain too large a proportion of the carbonaceous and fermenting foods, form a main part of the predisposing cause of cancer." Alcohol and Chronic Irritation Abuse in food and abuse in drink are closely related. Chronic irritation as a result of overindulgence may safely be considered a predisposing factor in at least the occurrence of cancer of the stomach. Some early writers on cancer attributed the disease to the general use of acid wines and cider. The available evidence, however, is not conclusive, further than that excessive indulgence in alcoholic drinks is quite likely to produce a chronic gastritis, which requires to be considered as a precancerous disease. Hepatic cirrhosis is induced in chronic alcoholism in many cases, but especially in those who habitually take whiskey undiluted into an empty stomach. This habit is certainly not very general in this country. The common use of raw whiskey has been connected by Boas with cancer of the oesophagus. Reyburn, in an interesting discussion of the medical treatment of cancer considers the influence of alcohol as a predisposing 183 TEE MORTALITY FROM CANCER cause in cancer, particularly as regards the insidious and dangerous effect of alcohol on the tissues, even from small quantities, when taken regularly, and the effect of alcohol in the dilute form to enter into the blood and then circulate in the blood through every tissue and organ of the body.* He therefore concludes that the effect of this is that "The alcohol, by powerful affinity for the water of the tissues, dehydrates and prematurely hardens them ; not only this, but alcohol is a retarderof waste in the body." Sir Alfred Pearce Gould, in the Bradshaw Lecture on Cancer, reported in the British Medical Journal for December 10, 1910, considers alcohol an etiological factor of considerable importance. Referring to the occu- pational mortality statistics, according to which persons connected with the liquor traffic show an exceptionally high mortality figure from cancer, he concludes that "the cancer incidence in any trade varies with the attendant habits as regards alcohol;" and from the point of view of chronic irritation, X-rays and alcohol — these so-called causes of can- cer — agree in being conditions that wear out the cells of a part : they add to the number of cell generations, they deteriorate the evolution of the individual cell, they appear to lessen the hold over the cell of the great primal cell law, and singly or in combination they cause cancer. There is serious risk, however, in carrying this conclusion too far. A few years ago a report was published on the experience of Inebriate Asylums in England, according to which "the mortality from cancer was more than eight times greater than that which obtains throughout the coun- try." This startling conclusion was subjected to critical analysis in a Second Study of Extreme Alcoholism in Adults, by David Heron, Galton Research Fellow, of the Francis Galton Laboratory for National Eugenics, with the result that the very opposite conclusion was arrived at, or in other words, the frequency of cancer was found to be less among inebriates than among the general population. Bainbridge points out that the prejudicial influence of alcohol on cancer is a debatable question, but he observes, "In the case of the alimen- tary canal, at any rate, this possibility has been practically estab- lished by the greater frequency with which males suffer from cancer of the upper half of the alimentary canal and stomach, especially in occupations prone to alcoholic indulgence."! Hastings Gilford, in his treatise on "Disorders of Post-Natal Growth and Development," con- cludes that there is no clear evidence that cancer in general is due to the drinking of alcoholic intoxicants. He quotes Dr. Snow J as one who in com- mon with many other observers believes that alcohol has a conspicuous share in giving rise to cancer of the lips and tongue. He also quotes Sir Victor Horsley, to the effect that "There is a great excess of [malignant] disease in persons employed in those occupations in which alcoholic indul- gence is common," and "This is not surprising when we remember that one of the factors producing cancer is the influence of chronic irritation, and alcohol causes irritation of the tissues with which it comes in contact." There can be no question of doubt but that alcohol is a cause of degenera- tion, and Gilford elsewhere observes that "the tissues of the alcohol drink- er are more vulnerable than the water drinker, and that, furthermore, * Journal of the American Medical Association, November 10, 1906, tWilliam Seaman Bainbridge, "The Cancer Problem," p. 81. tThe Lancet, 1904, Vol. ii, p. 822. (See also "Disorders of Post-Natal Growth and Development," p. 162.) 184 OBSERmriONS AND CONCLUSIONS the stimulating effect of alcohol is to a large extent the result of an increased flow of blood, not founded on physiological reasons, and any increase of gastric juice, any extra warmth of the skin or exaltation of mind so produced is pathological, for it is due to a morbid congestion and not to a natural flush. The action of alcohol upon the healthy stomach is essentially that of a disorder, and carries with it all the evil which the word implies." In the cancer investigation in Baden one of the predisposing conditions determined with approximate accuracy was alcoholism, which accounted for about 7.5 per cent, of the cases returned for the year 1904 and 6.25 per cent, for the year 1906. In contrast, nicotine abuse, or smoking in any form, was accounted for in only 1 per cent, of the cases for 1904 and 0.75 per cent, for the year 1906. Even chronic inflammation and irritations caused by gall-stones, etc., accounted for a smaller proportion of cases than alcoholic misuse. Smoking and Chronic Irritation Alcohol and tobacco are unquestionably sources of chronic irritation in the mouth and throat. The relation of smoking to cancer of the buccal cavity is apparently so well established as not to admit of even a question of doubt. Betel-nut chewing may here be referred to as an etiological factor within the same category. As pointed out by Childe, in his treatise on "The Control of a Scourge," if oversmoking, or smoking at all, irritates the mouth and tongue and gives a feeling of soreness, it is advisable to discontinue the practice, and he particularly suggests the abolition of the clay pipe. The subject was inquired into in connection with the special cancer investigation in Ireland, published as a supplement to the thirty-eighth detailed annual report of the Registrar- General, Dublin, 1903. On the basis of this investigation the conclusion was arrived at "that in some cases cancer has supervened where there has been irritation of the lip consequent on smoking clay pipes. W. R. Williams in summarizing the available evidence on the relation of smoking to lingual and buccal cancer, concludes, however, that intrinsic causes are much more important factors in the origination of cancer than extrinsic ones, which are by no means its necessary antecedents. The fact, however, that the mortality among males from cancer of the buccal cavity is almost invariably greatly in excess of the corresponding death rate for females is in itself indicative of the etiological importance of smoking. An extremely suggestive illustration in support of this con- clusion is the relatively high mortality from cancer of the buccal cavity among aged negro women in the District of Columbia, who are given to the smoking of clay pipes; this habit is practically unknown among white women. For ages over 40 the death rate for cancer of the buccal cavity in the District of Columbia was 3.3 per 100,000 of population for white women, against 8.4 for colored women; but at ages 70 and over the rates were 8.6 and 30.1, respectively.* W. S. Lazarus-Barlow in the Croonian Lectures on Radio-Activity and Carcinoma, calls attention to the fact that the liability to cancer of the lip undergoes no diminution in old age, such as is observed in the case of carcinoma in all other sites examined by him. This he considers strong •"Menace of Cancer," p. 24 185 THE MORTALITY FROM CANCER evidence that some fundamentally different condition obtains in the two situations, and he therefore concludes that "The persistency with which the old man clings to his pipe, holding it between his lips, whether actu- ally smoking or not, whether awake or dozing, as he sits in the sun or by the fireside, is as characteristic of the ages above seventy as is the tooth- less condition which commences to set in about 65. On the assumption that the pipe is in some way related to carcinoma of the lip, while the teeth are in some way related to carcinoma of the tongue and other parts of the mouth, the curve of liability to this disease in the two situations should be exactly as we find them to be."* These conclusions of one of the foremost students of the cancer prob- lem are based in part upon the results of extended studies regarding the radio-active properties of clay pipes, which, however, are too tech- nical to be more than referred to. Dr. Louis Bradford Couch in a con- tribution to the Medical Times, November, 1911, approaching the sub- ject from another point of view, points out that the smoking of tobacco produces CO and CO2. "The latter," he remarks, "unites with the watery secretions of the mouth and lips, forming carbonic acid, the same factor involved by fermentation in the traumatized tissues, while the mechanical pressure of the pipe held regularly in one place on the lip, causes blood stagnation and local fermentation and poisoning by its resulting gases." He also directs attention to a fact of considerable interest, in support of which, however, the required statistical evidence is not given, that "Cancerous growths always occur on the lower lip, never on the upper lip,"t which fact, he contends, "corroborates my theories as regards the importance of pressure and fermentation." In other words, "The irritating character of the nicotine and pyridine that bathe the stem of the pipe as it presses on the lip, are factors of impor- tance. In smokers' cancer there are three active causes at work, i. e., the pressure of the pipe inducing stagnation of blood and fermentation of the tissues; nerve irritation induced by nicotine and pyridine; the mucous absorption of the gases of combustion, which alone and unaided cause vascular paralysis, resulting in fibrous exudations, which, becom- ing organized, cause the tumerous growth." The relation of cancer of the buccal cavity, and particularly of the lips, to smoking habits was also considered in the German Cancer Census of 1902. The conclusion is advanced that the greater fre- quency of cancer of the lips among men is directly attributable to the smoking habit, and the evidence of tobacco misuse was apparently established in nearly 16 per cent, of the male cancer cases. It is pointed out, however, that the habit of smoking is not to be considered a direct causative factor, but only in the sense of being a contributory one, in identically the same way as it is held that alcoholism requires to be considered a contributory instead of a direct cause in cancer frequency. Gall-stones and Chronic Irritation The foregoing considerations emphasize the practical possibilities of an extension of the method of qualified statistical research to special phases 'British Medical Journal, June 26, 1909. fThe accuracy of this statement, however, is seriously questioned by one of the foremost authorities on this particular aspect of the cancer problem. The statement is of special significance as an indication of the practical importance of detailed statistical data regarding the precise location of the cancerous growth. 186 OBSERVATIONS AND CONCLUSIONS of the cancer problem. Most of the theories advanced with regard to special contributory factors in cancer occurrence are insufficiently sus- tained by the necessary statistical evidence. The precise seat of local irritation should in all cases be correctly determined, but unfortunately it is in this direction that most of the general cancer studies fall short of the required degree of scientific conclusiveness. The confusion of cause and effect is as common in the cancer problem as in tuber- culosis. The several factors in their interrelation are no doubt often obscure. The division by Dr. WiUiam J. Mayo of local irritation into, first, congenital or acquired neoplasms, such as moles, warts and benign tumors, which might undergo malignancy, second, trauma, which strongly influences the development not only of sarcoma but also of carcinoma, third, chronic irritation, which is perhaps the most im- portant of all precancerous conditions, whether the result of mechanical, chemical or infectious agencies, is suggestive of the extreme complexity of the biological aspects of the cancer problem statistically considered. Among the illustrations given by Mayo are cancer of the gall-bladder from gall-stone irritations and cancer of the stomach following gastric ulcer. He points out that 50 per cent, of cancers of the pelvis and of the kidney were demonstrably superimposed on extensive renal calculi formation. He points out further that carcinoma of the appendix usually occurs in association with chronic obliterative processes, and in the sigmoid and rectum, the irritation in diverticula may have given rise to malignant disease. In each of these particular phases of the can- cer problem further research would seem especially desirable, due atten- tion being given to elementary principles of statistical analysis. Cancer and Tuberculosis The relation of cancer to certain other important diseases is a field of research which as yet has received only superficial or incidental con- sideration. Foremost among the diseases related to cancerous processes or assumed to be favorable or antagonistic to cancer occurrence are tuberculosis, syphilis, leprosy,* gout, rheumatism, diabetes, malaria and appendicitis. The early writers on the cancer problem considered scrofula as a primary predisposing cause, but during the nineteenth century this point of view changed to the opposite, on the basis of the homeopathic principle in medicine that two dynamic affections can not occur at the same time; in other words, the less persistent disease must yield to the stronger. This view was shared by Hunter, who, according to Wolff, held that the human body could be affected by only a single specific disease at one time. These conclusions were subsequently set aside by the evidence of coincident diseases, though, of course, coexist- ing to a variable degree of virulence. Tuberculosis and cancer may occur in the same person at the same time, but the coincidence is apparently not common. This coexistence of two diseases is possible not only in the body as a whole, but in any particular organ or part. The main factor *Per3onal inquiry at the Molokai leper settlement has failed to substantiate the view that there is a correlation of cancer to leprosy. Leprosy as a precancerous condition has been reported by Blaschko, but apparently the conclusions have not been generally accepted. J. W. Vaughan mentions Guy de Chauliac (1300 A. D.) as having declared that cancer was closely allied to leprosy, but no evidence in support of this theory has been produced- The age and sex incidence of leprosy follows an entirely different law from that of cancer, and the disease is most common among indigenous races, who, as a general rule, are relatively free from malignant disease. ♦ 187 THE MORTALITY FROM CANCER of etiological importance in connection with the two diseases is that tuberculosis occurs most frequently at young ages and cancer at ages over 45. In the United States registration area in the year 1913, out of 93,293 deaths from tuberculosis, 73.39 per cent, occurred at ages under 45, and 26.61 per cent, at ages over 45. Out of 49,887 deaths from cancer at all ages, 15.46 per cent, occurred at ages under 45, and 84.54 percent., at ages over 45. In so far as disease is a function of age, tuberculosis and cancer follow apparently opposite laws of frequency occurrence. Among the most recent statistical studies, according to Wolff, are the data of Goupil, who determined a proportion of 9 per cent, of tuberculosis cases in 622 cases of cancer. According to the investigations of Cahen, based upon 4,233 autopsies, the proportion of coincident cases of cancer and tuberculosis was only 5 per cent. Other investigators have found as high as 20 per cent., and W. R. Williams records 12.5 per cent. It would seem, however, that according to the more recent investigations the combi- nation of tuberculosis and carcinoma is much less than according to the earlier studies. This, in part, may be explained by the diminish- ing frequency of tuberculosis and the increasing frequency of cancer. In this respect, the two diseases also follow apparently opposite laws of frequency occurrence. The mortality from tuberculosis of the lungs in American cities during the last thirty years has declined from 319.3 per 100,000 of population to 157.5, or 50.7 per cent., whereas the cancer death rate of these cities during the same period of time has increased from 46.9 to 85.4, or 82.1 per cent. Much the same tendency is met with in other representative civilized countries. The theory of antagonism between cancer and tuberculosis was first promulgated by Rokitansky.* Summarizing the results of his own investigations, Rudolph Schmidt, in his treatise on "Tumors of the Abdominal Viscera," observes with reference to the theories of Roki- tansky that "Individuals with well-developed progressing tuberculosis of the lungs are extremely unlikely to have carcinoma. On the contrary, healed apical lesions and other stationary healed tubercular processes, or such as incline to healing, especially those of glands and bones, are decidedly not rare in cancerous patients." Among recent studies of the association of tuberculosis and malignant growth a reference may be made to the work of W. H. Harris of New Orleans.f The results of Harris's investigations are briefly summarized in the statement that "The tuberculosis formed a primary pathologic soil on which the tumor probably thus provoked continued to flourish and the tuberculosis in part yielded to the cancerous affection." Cancer and Syphilis The possible correlation of syphilis to cancer has also not been accu- rately determined. The earliest investigation, as stated by Wolff, was by *Journal of Medical Research, Boston, 1913. fThe extreme rarity of coincidence in cancer and tuberculosis is best illustrated in the actual experience of The Henry Phipps Institute of Philadelphia. From the opening of the Institute in 1903 to January, 1915, there have been 633 autopsies performed, including a very small percentage of individuals who did not have tubercu- losis. According to Dr. H. R. M. Landis, Director of the Clinical and Sociological Departments, "Of the entire number there was but one instance of malignant disease, and this case was of a woman who at the autopsy was found to have a number of nodules in the lung, which had had their origin in a small scirrhous carcinoma of the left breast. This woman had no tuberculosis whatever." In other words, in the experience of this thoroughly representative institution there have been no cases in which tuberculosis and malignant disetfee coexisted. 188 OBSERVATIONS AND CONCLUSIONS Leroy d'Etiolles, who according to French experience held that out of five syphiHtics one would be afflicted with cancer. The importance of considering the possible coexistence of syphilis and cancer, with a due regard to the organ or part of the body affected by the disease, was dis- cussed by Poirier in 1 907, in a description of 32 cases of cancer of the tongue in 27 cases of which syphilis was a predisposing or precancerous con- dition. Fabre, as early as 1777, attempted to prove that syphilis was an important factor in cancer causation, and since that time many writers have contributed the results of their observations for the same purpose. Horand has reemphasized the importance of considering the relation of syphilis, with a due regard to the site of the cancerous growth, but no evidence has apparently been produced to show that syphilis must be considered a specific predisposition to cancer, further than that all imperfectly healed lesions or cicatrixes are liable to assume a malignant form in course of time. Other writers on the subject have advanced opposite conclusions, including W. R. Williams, who observes that in the course of his investigations into the life-history of female cancer patients he has been struck by the extreme rarity with which signs of syphilis are met in such persons. Thus, out of 325 female cancer patients consecutively under his observation, not a single one had been addicted to prostitution, so far as he was able to ascertain; and, what was more remarkable, only a single one presented signs of having had syphilis. Moreover, according to this same authority, out of 160 uterine- cancer patients, only one presented signs of having had syphilis. Other indications furnished by a careful study of the life-history of these patients clearly show that they are seldom the victims of syphilis. He therefore concludes that "The victims of constitutional syphilis are much less prone to cancer than the non-syphilitic. And this comparative im- munity of the syphilitic is probably due to the depraved nutrition and lowered vitality, caused by contamination of the system with the syphilitic virus," The subject is referred to by David Heron in his monograph on "Extreme Alcoholism in Adults." The investigations by Dr. Branthwaite are mentioned as raising a very interesting point in discussing the rela- tionship between prostitution and cancer of the mammary and genera- tive organs. It is stated by Heron that "After correcting for differences of age distribution, we find that 71 per cent, of the cancer among inebri- ates affects those organs while in the general population the proportion is 53 per cent. Among inebriates who are prostitutes the percentage rises to 87.5 per cent, compared with 52 per cent, in the general popula- tion." It is admitted, however, that the numbers are small and do not justify further analysis; but the point is recognized as important and, it is suggested, should be tested on the basis of more adequate statistical material. Following these observations, however, it is pointed out that "None of those prostitutes who had cancer are marked as having had syphilis also, but it is not quite clear from the report whether other and less severe forms of disease have been recorded in addition to the principal disease." Reference is made to the conclusions arrived at by Prof. Rutherford Morison that "Cancer and syphilis are very firm allies and syphilis often provides a suitable site for the lodgment of 189 THE MORTALITY FROM CANCER cancer. If a person over 60 years of age contracts syphilis, his death from cancer may be anticipated." Heron also refers to the conclusions of Dr. F. von Esmarch as still more emphatic, and to the effect that in his experience during recent years in his own clinic he had observed in cases of sarcoma that more than one-half of the patients had been syphilitics, and that they were cured through antisyphiUtic treatment. It is obvious that these conclusions rest upon inadequate data, subjected possibly to a faulty statistical analysis. The cases of Von Esmarch may have represented an exceptional class of women, for there is no evidence to prove that syphilis would be met with to anything like the proportion stated by him in the ordinary run of male or female patients of a general hospital or of a large private clinic. The subject is one well deserving of further study and research, but as far as the present available evidence permits one to judge, the relation of syphilis to cancer is only remote. This view is sustained by the observations of Rudolph Schmidt, who remarks that his personal impression is that "So far as the clinical study of malignant neoplasms is concerned, luetic antecedents are not frequent." Cancer and Rheumatism The statistics of rheumatism and gout in their relation to cancer are fragmentary and inconclusive. Recamier, according to Wolff, considered gout a predisposing factor in cancer, particularly in the case of women. Bazin as early as 1858 attempted to correlate the two diseases, but apparently upon an inadequate statistical basis. Beneke, in 1875, and Vigouroux, as recently as 1906, have brought forward evidence in support of this contention. According to the last-named writer, as quoted by Wolff, cancer and arthritis are closely related; in fact, he goes so far as to maintain that the majority of cancer patients suffer from some form of arthritis, the fact, apparently not being given due consideration, that rheumatic afflictions are as such largely inci- dental to advanced age. The term arthritism as used by these writers is quite comprehensive, and apparently includes such widely different diseases as gall-stones, dyspepsia, diabetes, heart diseases, etc. Neither statistical nor clinical evidence has been brought forward in adequate support of this important contention. ' In a discussion on "Cancer in New Zealand," Hislop and Fenwick* observed, with particular references to cancer-houses, that "So many of the cases were rheumatic, and rheumatism was so -prevalent iii subacute or chronic forms in hush districts, that tve can hardly ascribe the coin- cidence of rheumatism and cancer to an accident." They add the rather suggestive observation that "It is not impossible to imagine that the circulation of the blood in rheumatic cases may act as a direct irritant to tissues." It may be said in this connection that dampness has frequently been alleged to be a contributory cause in excessive cancer frequency, and the theory has been advanced that well-wooded countries are almost constantly the areas of high cancer mortality, and that isolated houses surrounded by trees especially harbor the disease. Childe, in his treatise on "The Control of a Scourge," draws attention 'BritM Medical Journal, October 23, 1909. 190 OBSERVATIONS AND CONCLUSIONS to the close connection of "low-lying districts and trees as a cause of cancer," but he remarks that the contributory cause was more likely dampness, and he quotes the results of an analysis of 100 cases of cancer of the breast, in which 30 per cent, showed a well-marked history of exposure to dampness in some form or other, and he makes the rather unpractical suggestion that "Women should not reside in places with a damp climate, or where mists and fogs prevail." The relation of rheumatism to dampness is too well established to require explanation. Dampness as a contributory cause in rheumatism may, therefore, occur as a mere matter of coincidence in a relatively large number of cancer cases. In his classical treatise on the "Geography of Heart Disease, Cancer and Phthisis," Haviland drew attention to the coincidence of an excess in cancer frequency in the sections of England more or less subject to periodical inundation, and a consequential resulting dampness. He laid down the important principle that "Can- cer does not thrive on high, dry soil," and furthermore, that the facts prove that "Rheumatism is the forerunner of the great mass of heart disease," and that in cancer, "The high, dry sites on the older rocks are the places where cancer does not thrive, and that it does thrive in the vales by the sides of large rivers which overflow their banks, and in the neighborhood of which are to be found the drifts of ages of washings from the inhabited country above." No exhaustive statistical investigations have been made to establish with a reasonable degree of scientific con- clusiveness the coincidence of cancer and rheumatism in low-lying, damp, ill-drained sections of the country subject to a heavy rainfall, in contrast to high-lying, well-drained and semiarid regions. Much general in- formation is available, however, to prove that cancer in the former regions is more common than in the latter.* Cancer and Gout Gout, as perhaps the best illustration of malnutrition, may by in- ference be considered a precancerous symptom. But what is true of gout is equally true of cancer; as observed by Von Noorden, in his treatise on "The Pathology of Metabolism," "The leading scientific investigators have devoted their best efforts to the solving of the questions dealing with the theory of gout, yet our knowledge concerning its metabolic processes stands in marked contrast to the amount of thought expended upon the elaboration of its theory." The anomalies of the metabolism of gout, especially with reference to uric acid, may possibly be found to correspond to similar conditions in cancer. It is significant, however, that in England, where in the past gout has been most common, the mor- tality from this cause should have been on the decrease during years in which in contrast there was a marked rise in the mortality from cancer. The death rate from gout among males in England and Wales has declined from 3.7 per 100,000 in 1891 to 1 .8 in 1910. The combined death rate from all forms of rheumatism, including rheumatic gout, has declined from 12.6 per 100,000 in 1891 to 7.9 in 1910. In contrast, the mortality from all forms of cancer, including sarcoma, has increased during the same period from 51.8 per 100,000 to 85.7. It is remotely possible, of course, that *See also the discussion under topography, on page 196. 191 14 TEE MORTALITY FROM CANCER there has been a transference of cancer cases formerly classified under gout or rheumatic affections to the cancer group, but the evidence is quite conclusive, as a matter of general observation, that the typical form of gout so common in England 30 years ago is relatively less frequent at the present time. In 15 cases of applicants with a record of gout in their personal history in the experience of the Mutual Life Insurance Company, % died from gout; 4, from heart disease; 1, from Bright's disease; 2, from dropsy; 1, from apoplexy ; 4, from acute rheumatism; and 1, from tumor of the liver, but whether malignant or not is not stated. The evidence in this case would, therefore, have to be considered negative. The same conclusion applies to most of the available data regarding the possible relation of cancer to gout and other rheumatic affections. As yet, however, no thorough study has been made of the comparative frequency of cancer and rheumatic affections in typical semiarid and humid localities, with a due regard, of course, to the organs and parts of the body affected by malignant disease. Cancer and Diabetes There is also apparently a well-defined correlation between diabetes and cancer. The conditions responsible for nutritional disturbances may possibly be in part the same in both diseases. One of the con- tributory factors of considerable importance in diabetes is unrestricted "eating and drinking," or, in other words, overnutrition. Diabetes is usually rather frequent in the Hebrew race, but this is apparently not the case with cancer. "The pathogenesis of the disease," according to Savill, "is not at present known," but it is certain that the pancreas is fibrotic in about 50 per cent. He adds that physiological evidence points in this direction, and that the glycogenic function of the liver is in some way interfered with, possibly indirectly through the pancreas. The disease occurs chiefly among the well-to-do, and in the proportion of three males to two females. According to Gould and Pyle, "occasion- ally there are lesions of the pancreas, but usually no anatomic lesion can be found." The complications of diabetes are numerous, but they apparently do not often include cancer. The chief treatment is dietetic, and consists in the reduction of sugars and farinaceous foods. No such treatment, apparently, would be of much value, if any, in cancer. A high correlation between the death rate from cancer and diabetes was brought out in a statistical study by Dr. G. D. Maynard, of Johannes- burg, South Africa.* The evidence, however, can not be considered entirely conclusive. W. R. Williams remarks in this connection that *The original paper by Maynard was published in Biometrika for April, 1910. Among the conclusions advanced are the following: 1. That recorded differences in cancer and diabetes death-rates, as applying to different districts and cities of the U. S. A., as well as the increased rates observed in recent years, do indicate real differences in the preva- lence of the disease. 2. The correlations found to exist between cancer, diabetes and insanity are not fortuitous and due merely to errors of observation or record. 3. The statistics dealt with in this paper do not give any support to the suggestion that cancer is of infectious origin. 4. That whatever theory as to the causation of cancer is adopted, some explanation of the remarkable cor- relations between cancer, diabetes and insanity is required. 6. The explanation suggested to account for the facts as disclosed by statistical analysis is that conditions of modern life, acting on physiologically unsound material, may account for the correlations existing between these three diseases, as well as for their increasing rates. 192 OBSERVATIONS AND CONCLUSIONS it is interesting to note that "Of late many instances of the association of malignant tumors with diabetes have been reported, and most of those who have specially studied the subject maintain that the diabetic state favors the development of malignant disease." He points out that it is well known that malignant tumors "are rich in glycogen, and that the blood of those who bear these tumors contains an excess of sugar-forming substances." In his own experience, however, Dr, Williams noticed the diabetic state in only a few of his numerous cancer patients, and he remarks that other pathologists have also called attention to the rarity of this conjunction, "even when the pancreas is the seat of malignant disease, diabetes is far from common." The statistical evidence is very limited, but reference may be made to Boas, a German observer, who reports that of 366 patients with intestinal cancer, 12, or 3.3 per cent., were also affected with diabetes. WiUiams quotes 62 cases collected by Kappeler, according to whose investigations the seats of the can- cerous disease complicated by diabetes were as follows: breast, 18; mouth, 12; stomach and liver, 12; uterus, 3; rectum, 2; colon and ovary each in 1 case. The same writer quotes Frerichs regarding the cause of death in 200 diabetic patients, of whom only 6, or 3.0 per cent., died of cancer. Gilford,* in his discussion of diabetes and its association with acromegaly, liver cirrhosis, obesity and senilism, makes no reference to cancer. The evidence, therefore, as far as available, would seem to indicate that the actual correlation of cancer to diabetes is comparatively slight. In contrast to the absence of conclusive evidence of such correlation, the increase in the mortality from diabetes in civilized countries cor- responding, more or less, to the increase in cancer frequency, is of con- siderable interest, at least as a problem in statistics.! In England and Wales during the period 1900-12, the cancer death rate increased from 82.9 per 100,000 to 102.2, or 23 per cent., whereas the diabetes death rate increased from 8.6 to 11.1, or 29 per cent. In ten registration states of the United States during the period 1900-12, the cancer death rate increased from 63.8 to 85.3, or 34 per cent., whereas the diabetes death rate increased from 11.0 to 17.6, or 60.0 per cent. Since diabetes is much more common among Jews than Gentiles, the material increase in the diabetes mortality in the ten states referred to is, no doubt, due in part, to the large Hebrew immigration during recent years. That this, however, can not be the only explanation, if it is any explanation at all, is shown by the statistics for Norway. In that country the cancer *Hasting3 Gilford, "The Disorders of Post-Natal Growth and Development," London, 1911. fThe following comparative cancer and diabetes mortality rates are derived from official sources for the period 1908-12: Mortality from Cancer and Diabetes 1908-1912 Deaths United States of America (16 States) 150,750 England and Wales 174,602 Norway 11,461 Australia 16,096 Canceb Diabetes Rate per 100,000 Population Deaths Rate per 100,000 Population 76.3 30,047 15.2 97.6 19,149 10.7 97.4 865 7.2 73.2 2,006 9.1 193 THE MORTALITY FROM CANCER death rate increased from 90.8 to 104.8, whereas the diabetes death rate increased from 5.1 to 8.0. Cancer increased 15 per cent., against an increase of 57 per cent, in the mortahty from diabetes. Still more sug- gestive are the changes in the cancer and diabetes death rates of the Commonwealth of Austraha (1900-12). Cancer increased from 62.6 to 76.1, or 22 per cent., whereas diabetes increased from 4.2 to 10.1, or 140 per cent. The evidence, while inconclusive regarding a possible relation of cancer to diabetes, or vice versa, is of exceptional interest in view of the recognized underlying serious nutritional disturbances in both diseases. Cancer and Appendicitis The possible relation of cancer to appendicitis has been a matter of much interest for many years to students of the cancer problem. Howard A. Kelly, in his treatise on "Appendicitis and Other Diseases of the Vermiform Appendix," calls attention to the fact that "The number of cases recorded of primary tumors in the vermiform appendix is small, but during the past few years, since the operative treatment of right iliac disease and careful routine, laboratory examination of the removed organs has become general, it has been found that they are by no means so rare as formerly supposed." He also remarks that since 1898 "a considerable number of cases of malignant neoplasm limited to the appendix have been carefully described, while secondary involvement of the organ is. comparatively common." According to the same au- thority, however, it would appear that benign tumors are extremely rare. The investigations by Maydl and Nothnagel, concerning the occurrence of primary carcinoma of the appendix, as shown by autopsy records, are referred to, it being stated that out of 40,738 autopsies made at the Vienna General Hospital during the twenty-two years, 1870-92, only two cases of carcinoma of the appendix out of 343 instances of cancer of the digestive tract were found. During recent years the evidence from numerous sources has been rapidly accumulating, tending to show in the words of Dr. Kelly, that "Primary carcinoma of the appendix is not such an uncommon disease as has hitherto been supposed to be the case." "Mechanical irritation," he remarks, "appears to play an unimportant role in the development of tumors of the appendix." He points out, however, that "Considering the frequent occurrence of carcinoma following stones in the gall-bladder and bile-ducts, it is surprising how few cases occur similarly in the appendix." He refers to the ages at which maHgnant tumors of the appendix develop, it being shown that the large majority occur between the tenth and the fortieth year, or to be specific, out of 69 patients 58, or 86 per cent., occurred during this period of life. It is, of course, well known that the average age at death in appendicitis is much lower than in malignant disease, and the age dis- tribution of deaths follows a distinctly different curve in appendicitis than in carcinoma. According to Rudolph Schmidt, the diagnosis of malignant tumors of the appendix is difficult on account of their small size, for apparently "they do not lead to metastases and do not show unlimited growth." He therefore concludes that such tumors can hardly be looked upon as "malignant" in a clinical sense, even though they bear their histological characteristics. Dr. John A. Lichty of Pittsburgh, 194 OBSERVATIONS AND CONCLUSIONS In a discussion of the pathological relation of ulcer to carcinoma of the alimentary canal,* calls attention to the fact that in only 20 out of 5,000 cases of appendicitis was malignancy established. Mayo in an address on "The Prophylaxis of Cancer,"t refers to the investigation by MacCarthy showing that out of 5,000 removed appendices for so-called chronic subacute appendicitis, only 0.5 per cent, were carcinomatous, although the external appearance of these appendices did not always indicate such a condition. The subject was quite fully discussed in an editorial in the Journal of the American Medical Association, January 14, 1911, in which the results of a careful study are summarized in the statement that "Statistics from large clinics, where great numbers of appendices are removed and thoroughly examined, have shown with remarkable uniformity that not far from 0.5 per cent, of all appendices removed for all causes show thickenings, nodules or tumor masses which exhibit a microscopic structure warranting the pathologist in returning a diagnosis of cancer. ' ' It is observed, however, in this connection that ' 'Of late there has been a growing doubt as to whether, after all, these epithe- lial neoplasms in the appendix are true cancers, in spite of the typical invasion of the connective and muscular tissues by strands of columnar or spheroidal cells." Reference is made to a discussion at a meeting of the German Pathological Society in 1910, at which Winkler reported that he had "found at autopsies no less than six appendices showing changes of the type usually diagnosed as carcinoma, yet in none of these cases was there evident regional infiltration or local or remote metastases." The subject has also been discussed at a comparatively recent meeting of the Edinburgh Medico-Chirurgical Society, at which the new evidence presented was largely in the negative, and this may be summarized in the brief statement that "Cancer of the appendix, especially in spheroidal- celled cases, must be of a naturally benign type, comparable to rodent ulcer, locally invading but rarely giving rise to metastases." Parasitic Theory of Cancer Causation All studies of cancer frequency in correlation to other diseases are of value as contributions to the theory of the origin of cancer, or the cause or contributory conditions primarily accountable for the disease. The wide distribution of cancer among civilized races, and particularly in well-settled communities or districts, early directed attention to the possibility of its being an infectious or contagious affliction of mankind. Countless papers have been contributed to the parasitic theory of cancer, but in the main the conclusions of even the foremost authorities on the subject must be considered unconvincing. The entire question of cancer as a contagious disease, its direct or indirect transmission from person to person, the extremely complex question of cancer a deux, J has been exhaustively dealt with by Wolff in the first volume of his treatise on cancer. Many citations are given of observations based largely on individual cases, tending to prove the parasitical theory, but in the main the data must be considered inconclusive. The statistical evidence in support of the theory, particularly in regard to the so-called cancer- houses, cancer-streets and cancer-villages, is also largely in the negative. *Joumal of the American Medical Association, September 10, 1910. \J(mTnal of the American Medical Association, November 5, 1910. ti. Wolff, Die Lehre von der Krebskrankheit. Jena, 1907, Vol. i, pp. 519-710. 195 TEE MORTALITY FROM CANCER Charles P. Childe directs attention to the likeness of morbid new- growths in human beings to some of the large parasitic tumors of plants and trees as tending to encourage the belief in the parasitic origin of cancer, but he considers most of these as wholly fantastical. He points out that "Pathologists all the world over have been hunting for the parasite, and so many parasites have been found, and no sooner found than found wanting, that a sense of disappointment has resulted, a sort of natural reaction has set in against this explanation of the origin of cancer." He, however, accepts the parasitic theory as perhaps better than any other in explaining some of its phenomena, but the evidence he advances is quite inconclusive. Charles Powell White, in his treatise on "The Pathology of Growth," holds that the increased proliferative capacity of the cells can not be ascribed to specific parasites, and that "It does not seem possible in any other way to explain tumor growths by the assumption of a specific causal parasite." According to this exceptionally careful observer, "It is impossible to account for the histiomata on this basis, and it is equally impossible to explain the com- plicated tumors, such as blastocytomata, teratomata and compound sarcomata." There only remain, therefore, "the sarcomata and car- cinomata, and even in these cases the assumption of a specific parasitic origin leads to numerous difficulties." He enumerates three possibilities, as follows: (a) There may be a single parasite for sarcoma and carcinoma. In this case it is impossible to explain the regularity with which metastatic tumors repeat the structure of the primary. We never find a primary carcinoma giving rise to secondary sarcomatous tumors as we should expect if both were due to the same causal parasite. (6) There may be one parasite for sarcoma and another for carcinoma. Here again the similarity of the metastatic tumors to the primary provides an insuperable difficulty. If all forms of carcinoma were due to a single parasite we should expect that metastases in the liver, in some cases at least, would show the type of hepatic carcinoma: this does not occur. (c) Each form of sarcoma and carcinoma may have its own specific parasite. Here we are at once met with the difficulty that the different forms of these tumors are almost innumerable, corresponding to the innumerable kinds of cells in the body. While they may be reduced to a limited number of type forms, yet there is no sharp boimdary between the different groups, and there is a considerable variation within the limits of each group. We should have to suppose a different set of cancer parasites for each organ, and not only this, but we should have to assume a different series of parasites for each species of animal! The fact that tumors are found in all genera of the higher animals and have the same characters throughout, and yet it is impossible to graft a tumor from an animal of one species into another animal of a different species, while it is possible to do so within the same species, tells strongly against the theory of a parasitic origin. Upon the basis of the foregoing observations he concludes that the assumption of a specific parasitic explanation leads to insuperable difficulties in explaining the observed phenomena. He adds, however, "These difficulties entirely disappear if we consider the cancer cell itself as a parasite and cancer as a process of infection by cancer cells." This conclusion, however, has not been generally accepted. Topography and Cancer Occurrence Frequent attempts have been made at precise correlation of local topography to exceptional cancer frequency, particularly in support of the parasitic theory of cancer origin. So-called cancer houses, alleys, 196 OBSERl/iTIONS AND CONCLUSIONS streets and villages are occasionally referred to in the literature of the subject, and in some cases the evidence, if not conclusive, is certainly not far from convincing that exceptional contributory conditions may exist, the nature of which has not yet been disclosed by the most scientific methods of research. Behla, in numerous contributions to German medical literature and the publications of the Imperial Health Depart- ment, has brought forward evidence to prove that a low-lying, swampy area favors an excessive frequency of cancer occurrence. At Luckau, for illustration, Behla found that in the low-lying suburban section cancer was nine times more common than in the higher or more elevated portions of the city. The suburban section was surrounded by much stagnant water, which, it is implied, acted as a medium for the conveyance of cancer parasites. The investigations of Behla are largely relied upon in support of the theory of cancer causation advanced by Green, who quotes from Murphy's Surgery an interesting reference to a cancer district in which it is claimed that cancer was exceptionally frequent in corner houses. On the basis of a survey as part of a special study of conditions in Scotland, Green concluded that the cancer death rate was invariably excessive in towns lying in a hollow, moderately high in towns on distinctly steep or hilly sites, and invariably below the average in towns on slopes and sites with comparatively flat surroundings. The highest death rate given by Green, 7.02, is for the town of Forfar, described as a town 200 feet above sea-level in a kind of basin formed by the surrounding slopes. Other towns with high death rates are referred to as located in a basin, or sur- rounded on all sides, or hemmed in by rising ground, or overlooked by an amphitheater of well-wooded hills, etc. The lowest rate given by Green, 1.75, is for the town of Kirkintilloch, described as being located in a low flat plain ; and other towns with low rates are referred to as being sur- rounded by a wide tract of flat country, or nowhere more than a few feet above the level of the spring tides. The difiiculty with investigations of this kind is that the influence of topography is most likely to be obscured by other factors of equal, or even more pronounced, influence in causing variations in the cancer death rate. A precisecorrelation of such conditions to the growth and dissemination of a specific parasite fails invariably on the ground that the common occurrence of cancer under fundamentally different conditions remains inexplicable. The theory advanced by Green is that the special statistics collected by him, with, it requires to be said, unusual caution and care, "prove that it must be some element in the environment of the sufferer which induces the disease, and if we ad- mit this, we must admit an extrinsic origin." This conclusion does not necessarily follow; nor is this view at the present time accepted by any one of the leading authorities in the world on cancer causation. The view of Green, that "the longer one considers the question the stronger the presumption becomes that the cause is biochemical or parasitic" has, no doubt, some general evidence in its favor, but unfortunately the proof advanced has not stood the test of subsequent investigations, although it does not by any means follow that the parasitical nature of the disease may not be established in course of time. It is conceivable that with the further advance of biology,and particularly the minute study of animal and vegetable parasites, a micro-organism may be discovered 197 THE MORTALITY FROM CANCER which conforms neither to the one nor to the other, though having in common some of the functions of each. It is also quite conceivable, in fact fairly well-established, that of the three distinct groups of plant parasites, as classified by Delafield and Prudden, "1, Bacteria, or fission fungi (Schizomycetes), 2, Yeasts, or yeast fungi, or sprouting fungi (Blastomycetes), 3, Moulds, or mould fungi (Hyphomycetes)," the second group, under given conditions, may assume characteristics or perform functions quite at variance with the first and with the last. The bacteria are, as is well known, of the greatest importance, because of the fact that they are very frequently the immediate causative factors in serious disease, the course of which differs fundamentally and in all essentials from the clinical pathology of cancer. The micro-organisms of the second group are larger than bacteria, and they are the direct causative factor in blastomycotic dermatitis, which is described as "a localized inflammation, papular and pustular in character, leading to warty outgrowths, to the formation of abscesses beneath the skin, and to ulcers." A generalization of the blastomycotic infection, under given conditions, may prove fatal. According to Delafield and Prudden, there are several forms of blastomycetes, but their classification is un- satisfactory. These references to biological consideration are sufficient to illustrate the very complex and ultrascientific character of the possible underlying and as yet undiscovered specific causative factors responsible for malignant tumor formation. The hypothesis, therefore, that cancer may be caused by micro-organisms entering the system from without is by no means unsupported by evidence entitled to scientific consideration. The difficulty lies in the practical application of the knowledge at present available to so extremely involved, widely varying, and apparently ever-illusive a problem as a high or a low degree of cancer frequency under apparently more or less identical external con- ditions. Cancer-Houses The practical importance of these studies lies in their application to the theory of cancer infection through some medium of contagion as yet undiscovered, but apparently met with in an exceptional degree of virulence in certain areas described as cancer-villages, cancer-streets, cancer-houses, and even cancer-rooms. Green cites such a house in the third edition of his statistical study of the cancer problem, which was located in his own district, and "which had ultimately to be pulled down owing to the great number of deaths from cancer which occurred in it." Wolff, in the third volume of his treatise on cancer, reviews the literature of the controversy, which has recently been revived by an extended discussion by Sir Thomas Oliver, of Newcastle-on-Tyne, and a counter statement by the Director of the Imperial Cancer Research Fund, in the Twelfth Annual Report of the Fund, issued under date of July 21, 1914. In brief, it would appear that the large majority of so- called cancer-houses were old, mouldy, damp, badly ventilated and other- wise unsanitary. Norwegian observers have called attention to the exceptional frequency of cancer in old farmhouses, and similar reports have been made for certain sections of Germany, including references to old rectories occupied by the clergy. In all such cases it is obvious 198 OBSERVATIONS AND CONCLUSIONS that there would be, at least as a matter of frequent coincidence, a pre- ponderance of aged persons of the cancer period living in the houses referred to. Old, dilapidated, damp and neglected houses are usually the refuge of the aged poor, unwilling to go to almshouses or other institutions for the aged. An old rectory or parsonage would generally be the home of a clergyman of the advanced cancer age. Old farm- houses would be most likely to be used, if only for sentimental reasons, by the aged members of a family, of which the younger members had married and gone to live elsewhere. In all of the cases referred to, there would be, in all probability, if but as a matter of coincidence, a larger proportion of aged persons of the cancer period than in the popula- tion at large. The controversial aspects of this question can not be reviewed here further than by the following quotations from the Twelfth Annual Report of the Imperial Cancer Research Fund (1914), which contains an exceptionally valuable review of the literature of the subject and some instructive statistical calculations and observations which must be considered a most useful addition to our knowledge of this important phase of the cancer problem. It is said in the report referred to, in part, that "The term 'cancer-house' appears to have been introduced in 1892 by the late Dr. Law Webb, who was a general practitioner not claiming special knowledge of pathology or bacteriology, but who col- lected the cases occurring in his practice and wrote as follows: *Dr. Haviland insists that a study of the Registrar-General's returns shows the existence of "cancer-fields" and "cancer areas" in this country, and that soil and situation have much to do with the mortality from this disease. I would go further and suggest that there are cancer-houses and cancerous wells or water-supplies.' Dr. Webb left the question open as to whether the 'noxious material is irritating chemically, or is a particulate body, such as a bacillus or a protozoon' ; but those who have followed in his wake have adopted the infective hypothesis, and to quote Dr. Webb have maintained that 'the children of cancerous parents when themselves past middle age, may contract the disease by pro- longed contact with the sufferer during the nursing of a lingering case or by handling and washing linen, etc., soiled with discharges. Again, does this poison, or materies morbi, cling to, and infect certain localities like the leprosy described in Leviticus?' Dr. Webb imagined the question he had raised was a perfectly simple one, 'A research demanding neither laboratory nor expensive instruments does not often present itself in these days; yet here is one.' The idea of its simplicity is still encouraged, and the public is being misled by assertations as to the value of enumerating houses in which one or more cases of cancer have occurred. Such enumerations, if they are to have any value at all, could only be preliminary to determining whether cancer was more frequent in certain houses than was to be expected if cases of cancer were not derived by communication." Pointing out that, on the basis of the returns of the Registrar- General for 1911, the chance that a man over 35 years of age will die of cancer is one in 9.7, and the chance for a woman above the same age is one in 7.4, the following table is introduced as tending to show how 199 TBE MORTALITY FROM CANCER often on the basis of these proportions no death, or one, two, three, etc., deaths from cancer may be expected to be recorded in 100 famihes, half the members of whicli are men and half women, and in which no heredi- tary tendency or infection is assumed, and in which all persons dying under 35 are excluded: Table Showing the Probability of Multiple Cancer Cases in Groups of Persons of the Numbers Stated Without Assuming Hereditary Tendency or Infection Number of Cancer Deaths in Family None Per 100 Families of 6 Members, viz. 3 Men, 3 Women 47 38 13 100 Per 100 Families of 8 Members, viz. 4 Men, 4 Women 36 39 19 6 100 Per 100 Families of 10 Members, viz. 5 Men, 5 Women 28 One 38 Two 23 Three or more .... 11 100 It is properly pointed out in this connection that the determination as to whether cancer is more frequent in certain houses than in others is much more complex than the simple arithmetic of enumeration. These words of caution can not easily be overemphasized, since a large number of factors and conditioning circumstances require to be known and reduced to measurable and comparable proportions. Dr. Bashford submits a fairly complete analysis of five of the best known instances of cancer-houses, based upon special studies and visits to the places reported upon. The results conclusively prove at the outset that some of the fundamental requirements of statistical inquiry were ignored and that in the main the conclusions throughout were made to rest upon an inadequate numerical basis of fact. Numerous actual and serious errors in the original statements were discovered, and subjecting the data to cor- rection, quite different conclusions were reached. These errors in- cluded misstatements in age, occupation, alleged site and the certified causes of death. Without enlarging upon the details of the investiga- tion, which appears to have been made with exceptional thoroughness, and the complete results of which, it is intimated, will be published in due course, the results are summarized in the statement that " 'Cancer- houses' are as much a myth as are 'cancer-cages' [in connection with experiments on animals]. The advantage of the experimental method is clearly brought out when it is recalled that 73, 33, 26, and 20 years of observation on man have only led to inconclusive and, according to present knowledge, quite erroneous results. . . . Some of the interest attaching to 'Cancer Houses' and 'Cancer Villages,' not only for laymen but also for some members of the medical profession, is due to the mystery that is made of them — the places go unnamed. " A special reference is made to the case of Ayr, in Scotland, where upon subjecting the facts to qualified analysis it was found that the pre- dominating contributory condition to the excessive cancer death rate was the great preponderance of elderly people in the populations con- sidered. The discussion having been originally raised by Mr. D'Arcy Powers in 1898 and 1903, the new facts were brought to his knowledge, 200 OBSERVATIONS AND CONCLUSIONS and he agreed with the explanation provided by the additional data. The hope is therefore expressed by the Director of the Imperial Cancer Research Fund that "the dangers of 'cancer-houses' will cease alike to alarm the public and to divert the energies of investigators from fruitful lines of inquiry." In commenting upon the observations by Sir Thomas Oliver with reference to the same subject. The Lancet, in an editorial discussion of "Cancer-Houses," remarks: "Conviction before the tribunal of public opinion is liable to be obtained by looser and easier methods than before a court jealous to observe and trained to apply the laws of scientific evidence. The difficulty is to obtain a series of houses in which the requisite series of cases of cancer can be found to have occurred, and to eliminate from those cases the possibility of their having been due as much to hereditary tendencies, which in the sifting of evidence cannot be ruled out, or to industries causing a predisposition to cancer, or to other influences. That successive cases of cancer should appear in a single house or in a group of houses is not in itself surprising, for it is not a rare disease, population has increased, and there are crowded areas and houses in which many persons will be found who are of the age with which the development of cancer is associated, so that the element of coincidence is not easy to eliminate. Unfortunately, the romantic mind never will try to eliminate it; the romantic mind revels in the trouble caused by coincidence," Cancer- Villages Strictly localized intensive cancer studies would unquestionably add much material of great value to the cause of cancer research. Regardless of the inconclusive character of practically all the observations on so- called "cancer-houses," "cancer-streets" and "cancer- villages," the fact is incontrovertible that an enormous range in cancer frequency is met with throughout the world, and that as yet no generally acceptable theory in explanation of such a wide degree of divergence has been ad- vanced. An auspicious beginning in the direction of the study of areas of excessive cancer frequency in the state of New York was made by Lyon in behalf of the New York State Institute for the Study of Malig- nant Disease. Lyon found an area comprising some 75 square miles in Brookfield Township, Madison County, New York, in which among a relatively small population excessive cancer rates had prevailed for a period of years. Unfortunately, the investigations were discontinued, but as shown in my address on the Menace of Cancer, the rate of cancer frequency in this section of Madison County has remained excessive to the present time. It is suggestive that this observer found Brookfield a poor rural community, in which a livelihood was obtained with difficulty. The average age at death was 54.4 years, which would indicate a rather high proportion of population of the cancer age; but after making allow- ance for the age factor, the local cancer death rate was still found to be excessive. After discounting the factor of longevity and errors in diagnosis, Lyon concludes that heredity and consanguinity are the special factors that have operated with peculiar force in Brookfield to produce the high cancer mortality over that attributable to the factors already 201 THE MORTALITY FROM CANCER considered. He is careful to point out that the acceptance of the factor of heredity does not necessarily commit one against the parasitic theory. The evidence concerning cancer-houses, as such, was rather negative, and cancer foci were not found to exist, "unless the houses with multiple cases could be so regarded." Four instances of cancer in husband and wife were found. In the main, the data are inconclusive. Only 84 deaths were con- sidered, and of this number 33 were due to cancer of the stomach, 10 to cancer of the uterus and 8 to cancer of the breast. The deaths were not calculated on the basis of the population exposed to the risk of cancer according to age, but the proportionate method was used, which for the present purpose, particularly in view of the small number of cases con- sidered, must be rejected as inadequate. The final conclusion of Lyon that the district investigated "represents a concentration of cancer families rather than cancer-houses," is also debatable, if carried to the point of providing support for the theory of hereditary disease trans- mission. It is extremely regrettable that these investigations should not have been carried further, and that the available data should not have been subjected to a more critical and qualified analysis. It would hardly serve a practical purpose to review in further detail the numerous special investigations of alleged cancer-houses or cancer- districts. The motive of such studies to establish a preconceived theory of infection or contagion discounts the scientific value of the conclusions advanced. Lazarus-Barlow is referred to* as having put forward the rather novel theory that the presence of some radio-active substance in the building material, or even in the soil upon which such (cancer) houses were erected might account for the higher frequency of the disease in some localities or particular groups of houses than in others. The interesting statement is made in this connection that this point of view did not "necessarily conflict with Cohnheim's theory of embryonic rests or with Virchow's theory of mechanical irritation or with Adami's theory of habit of growth, since radioactivity in the causative agent or in the tissues might be the underlying force in each. Even the microbic theory might be reconciled with this idea, for it is supposable that the assumed bacterial or protozoan agent in such case might be radioactive." The evidence advanced, however, can not be considered final, but, as observed in the discussion referred to, "Nevertheless this work, inconclusive as it is in its results, is deserving of careful study and extension. . . . Further investigations along this line may indeed explain away discrepancies now precluding an acceptance of the theory of infection, but even should they fail to do so, work of this kind is never fruitless and it may prove to have an important bearing on other biological problems, even if it does not explain the origin of cancer." Evidence of Parasitical Origin Not Conclusive Briefly reviewing some of the most important contributions to the study of the possible parasitical origin of cancer, mention may be made of the following: Hoeber has reported for Augsburg, Germany,! the results of an extended investigation, presented in a number of tables 'Medical Record, New York, August 7, 1909. tZeitschrift flir Krebsforschung, Jena, 1904, Vol. i, p. 173. 202 OBSERVATIONS AND CONCLUSIONS and maps, showing the cancer-houses, the soil and geological foundation, etc., and the coincidence of tuberculosis, but he was unable to discover any connection between the occurrence of cancer and the height, drainage and other conditions of the houses. He found that both cancer and tuberculosis were most prevalent in the poorer quarters.* In the Thames Valley, the statistics of all the counties indicate a cancer death rate above the average for England as a whole. "The statistics seem to justify the conclusion that this section has a relatively high mortality from cancer and the uniformly high rate on both of the banks suggests that there may be a connection between the river floods and the extent of the disease," which, however, is not explained on the assumption of a parasitical origin of the disease. These studies suggest that the drying vegetation on the river-banks may be a favorable nidus for the growth of the parasite, but this would not explain the increase of cancer, which seems everywhere apparent. f It has been pointed out in this connection, in the Journal of the American Medical Association, March 25, 1905, commenting upon recent contributions to the literature of cancer parasites by Robertson and Wade, following Behla and Gay lord, that "The fallacy of the cancer house theory, however, has been proved by the careful work of Lyon, who has shown that house collections of cases are far better explained by the influence of heredity and an in-and-in breeding than by infec- tion." Referring to the investigations of Dr. Munch Soegaard of Norway, the British Medical Journal of December 24, 1910, remarks that Since the total number of cases with which he deals is so small, and the possibilities of error are so large, it is unnecessary to follow up his cases any further in respect to inheri- tance. We may, therefore, register the verdict with regard to this account as "not proven." He calls the cottages in which some of the patients lived and died "Krebshofen," or cancer cottages. His observations lead him to summarize that in 18 out of 68 cases the cancer patient had lived in intimate contact with another cancer patient. The cottages or "Hofe" are described in vivid colors, and certainly appear to be veritable insanitary nests, in which infection might readily occur. But where overcrowding and other evils are found, it must be assumed that other factors of a deteriorating type must also prevail, and the mere occurrence of cancer in several persons living in these hovels does not prove infection. In the same way, when he tries to prove infection by citing the experience that those persons who left the neighborhood to live elsewhere escaped from the ravages of the terrible malady, while those who remained at home were more or less attacked, it must be emphasized that other factors have to be taken into consideration, of which the mode of feeding, the habits with regard to irritation and local stimulation, may be in- stanced. Again, it is inconceivable that one infection should at times produce carcinoma, and at other times sarcoma, and at still others rodent ulcer. Dr. Soegaard records cases of all three arising in one and the same environment. The cancer census of Baden is briefly referred to in the Journal of the American Medical Association for October 12, 1911, as follows: Werner's exhaustive study of conditions in the state of Baden in regard to the occur- rence of cancer, seems to show that external factors, physical, chemical or parasitic, com- pletely overshadow in importance the biologic-hereditary factors. In the cases of con- jugal cancer, the organs involved excluded direct contact as the growths were generally in the stomach, and never on the skin, lip or genital organs. Contact infection is ren- dered improbable further by his figures showing that cancer is least prevalent in the predominantly industrial communities. It seems to occur according to laws which have been seen to prevail in the occurrence of the non-contagious infectious diseases connected with local conditions. This fact affords new evidence as to a possible parasitic origin of * Journal of the American Medical Association, March 26, 1904. ] Journal of the American Medical Association, April 30, 1904. 203 THE MORTALITY FROM CANCER cancer. An inherited predisposition is not the prominent factor previously assumed or the influence of heredity would have been more apparent in the data he has collected. In some of the districts the number of cases is steadily decreasing, in others increasing; twelve communities were entirely free and 1,001 had much less than the general average, while 575 had much above the average, but no common geologic, hydrographic, climatic or architectural factors could be detected as responsible for this frequency or scarcity of cancer, nor age, sex, social standing, race, occupation or diet, nor distribution of the fauna and flora of the district. Werner's recent more detailed study of twenty-seven of the places where cancer is most prevalent and forty-six where it is least so has demon- strated anew that the difference in prevalence of cancer cannot be explained by the differ- ence in the proportion of elderly persons, but seems to be connected in some way with the place. In the same discussion the conclusion is advanced with reference to cancer frequency among blood relations and cancer-houses that These data completely disprove the assumption of cancer families, but add new sup- port to the assumption of cancer houses and neighborhoods. Sir George Beatson in a discussion of the cancer statistics of Scotland for the period 1861-1900, read before the Royal Society of Edinburgh, brought forward some rather interesting views on the cancer problem, briefly summarized in the statement that: Cancer as a disease occurs not In the decline of life but on the cessation of reproduc- tive life. Climate and geological conditions do not affect the question. Whether so- called "cancer homes" are instances of coincidence or not is not settled. The only pre- ventive measure which suggests itself as of any value is notification which would give more accurate information as to where the disease arises.* Poppelmann is authority for the statement, based, however, upon only 85 cases of cancer in a town of 8,000 inhabitants, that "the results show that the houses which stood nearest to water courses, and especially to stagnant water, showed much the larger proportion of cancer cases. The principal focus proved to be the region from the backwater from a dam." He urges the compilation of statistics, with maps, of small towns, where conditions are better known than in cities, with a special regard, however, to the location of cancer deaths in houses near brooks, rivers and dams. From quite another point of view the subject has been approached by Wilfred Watkins-Pitchford, Government Pathologist of Natal, in a paper on Light, Pigmentation and New Growth,t who points out that "Cancer has been found to be slightly more prevalent among those who are the more exposed to actinic stimulation — seamen, dwellers beside lakes and rivers, agricultural laborers, etc., etc.," and "Cancer houses usually appear to be unwholesome dwellings, often affording special facilities in their immediate neighborhood for the irradiation of their anemic in- habitants." Commenting upon the local incidence of cancer in New Zealand, Hislop and Fen wick, J after referring to the investigations of D'Arcy Power conclude that "The neighborhood of the native bush and bush streams seems to have some distinct connection in the origin of the disease. Malaria may not be antagonistic to cancer, but it is significant that where malaria is common cancer appears to be rare. It may not be improbable that there is some malarial poison antagonistic to the growth of cancer *Medical Record, New York, July 6, 1912. ^British Medical Journal, August Zl, 1909, tBritish Medical Journal, October 23, 1909. OBSERVATIONS AND CONCLUSIONS cells. So many of the cases were rheumatic, and rheumatism is so prev- alent in subacute or chronic forms in bush districts, that we can hardly ascribe the coincidence of cancer and rheumatism to an accident. It is not impossible to imagine that the circulation of the blood in rheumatic cases may act as a direct irritant to the tissues." In the case of most of these investigations the facts relied upon are, as a rule, entirely inade- quate for the purpose of establishing a scientific theory of cancer correla- tion to local conditions more or less superficially described. The evi- dence regarding specific cancer-carriers has not been forthcoming, although at the second International Cancer Conference* Dr. Borrel gave an account of his views on "the possibility of cestodes and Demodex fulfilling the part of intermediate hosts or carriers of a hypothetical cancer virus." This view has been vigorously criticized and has not been generally accepted. Equally inconclusive were the results of a special study by Dr. George D. White of five cases of cancer with four deaths in a certain district of Jersey City, particularly for the purpose of proving the possibility of contagion or the parasitical or bacteriological factor in the propagation of malignant disease. It has seemed necessary to review at some length the salient points of a controversy of long standing in view of the practical importance of the question whether cancer frequency can be precisely correlated to specific determinable local factors or conditions. In view of the truly enormous frequency of cancer, it would seem a foregone conclusion that if such a correlation existed, it would not be difficult to provide the necessary indisputable evidence. The proof, as far as can be gathered from a care- ful reconsideration of the published evidence, is, therefore, opposed to the theory of the parasitical origin of malignant disease and its spread by personal contact or by transmission from person to person by some carrier at present unknown.f Cancer a Deux or Infection of Husband and Wife Closely allied, in fact interminably interwoven with the theory of cancer-houses, is the theory of cancer infection of husband and wife. There are, no doubt, cases of coincident cancer occurrence in husband and wife, and in a very few of these cases the form of cancer in both has been the same. Weinberg found that in Stuttgart, during the period 1873-1902, of the widowers and widows dying of cancer, the frequency *British Medical Journal, October 22, 1910. fThe following is a suggestive reference to the relation of cancer to locality, by W. S. Lazarus-Barlow, in his third lecture on Radio-Activity and Carcinoma (British Medical Journal, June 26, 1909): "On the other hand, it [the theory of the radio-activity of scotographic materials] would not be opposed to a belief in 'cancer houses and localities,' for there is no reason why the soils of districts or the materials of which houses are built should not differ in the degree to which they are radio-active, nor why the local radio-activity should not be in certain instances so considerable that cancer arises in successive inhabitants time after time. In a sense the electrical department of every hospital is a 'cancer house.' It would not be opposed either to an infective or non-infective, a contagious or non-contagious, an animal or vegetable parasitic, a parasitic or non-parasitic, a hereditary or non-hereditary view of cancer, for it would only be concerned with the question whether the in- culpated agent is radio-active or not. So far as certain bacteria possessed the properties we are considering, the carcinoma associated with them might be regarded as bacterial and infective, but the bacterial and infective properties would be accidental and non-essential. So far as the agent which leads to hereditary transmission was provided with 'radio-active' properties cancer would be hereditary, but the inheritance of cancer would be accidental and non-essential. Similarly it would not be opposed to Cohnheim's theory of embryonic rests, to Virchow's theory of mechanical irritation, to von Hansemann's theory of anaplasia, to Ribbert's theory of tissue tension, to Adami's theory of habit of growth — for it would constitute the underlying force required by each." 205 TEE MORTALITY FROM CANCER rate in proportion to the population was not above the average. Frief of Breslau determined the number of cancer cases among surviving husbands and wives, but the mortality was not abnormal. Smith of Santa Clara, California, in 1895 reported the case of a woman 68 years of age whose death from cancer of the breast was, six months later, followed by the occurrence of cancer of the stomach and liver in her husband. Such cases, however, are apparently merely a matter of coincidence or pure chance. If cancer were in any appreciable number of cases transmitted from husband to wife, or vice versa, the number of recorded cases should be very large, in view of the general frequency of the disease after forty. The precarious nature of the statistical data on the subject is best illustrated in the results of the Baden Cancer Census, according to which the suspicion of direct cancer transmission from person to person was indicated in the returns for 1904 in the proportion of 4.8 per cent, and in the returns for 1906 in the proportion of 10.7 per cent, of all the cancer cases under observation.* The same question was considered in the Hungarian cancer census from the point of %new of direct contact, of living together in the same house and of contact with cancerous animals, but the results were inconclusive. Only two cases were recorded in which there might possibly have been cancer infection as a result of marital relations, but such statistical evidence unsupported by additional details derived from medical sources can not be considered conclusive. It has been observed in this connection by W. Roger WiUiams that "If cancer could be proved to be an inoculable contagious maladyj the question as to its causation would be greatly simplified, in favor of extrinsic factors ; but, so far as we have hitherto examined this question, no reliable evidence of contagion has been forthcoming." Referring to his eight years' experience at the ISIiddlesex. Hospital, he adds that he had never noticed "a single fact that could possibly be construed as evidence of the communicabil- ity of malignant disease from one human being to another," but to the contrary, he noticed "many indications which seemed clearly to imply, that the disease was neither infectious nor contagious." He reviews the evidence published from time to time regarding the recorded cases of transmission of cancer from one human being to another, but he con- cludes that "the evidence adduced as to contagion in these cases is of such a flimsy and obviously unreliable nature as to absolve me from the necessity of detailed refutation." No Surgical Infection in Cancer Operations If cancer were contagious, infectious, or, in other words, transmissible from one person to another, it would naturally be expected that sur- geons employed in cancer operations would, at least occasionally, fall a victim to the malady in the course of their occupation. Cases of surgical infection are by no means uncommon in the case of many in- fectious or contagious diseases, but there is not a trustworthy recorded case of a surgeon having acquired the disease in the course of contact *The identical question is raised in discussions of the relative frequency of tuberculosis in husband and wife. The matter has been thoroughly considered by Longstaff in his "Studies in Statistics," in a chapter on a Calculation of the Probability of the Accidental and Fatal Incidence of Phthisis upon Both Husband and Wife, London, 1891, p. 384. The negative conclusions arrived at apply with equal force to the theoretical probability of cancer infection of husband and wife. 206 OBSERVATIONS AND CONCLUSIONS in consequence of surgical operations for cancer. Dr. George W. Crile, in his oration on Surgery at the Fifty-ninth Annual Session of the American Medical Association, after reviewing the few spontaneous cancers that have been successfully transplanted from one animal to another of the same species and after mentioning the fact that no cancer has as yet been successfully transplanted from one animal species to another species, points out that the surgeon's immunity from cancer infection during cancer operations is practically complete. Dr. Willy Meyer, in an address before the Cancer Research Institute,* in reply to the question as to whether cancer was infectious or con- tagious, or both, observes that, "One had never seen nor heard of a patient afflicted with the disease conveying it to his wife. Nor had they ever heard of a nurse caring for a patient with carcinoma for months ever becoming stricken with the disease. Nor had he ever heard of a surgeon who, for instance, had injured his finger during the perform- ance of some operation on a cancerous subject ever developing cancer. It did therefore not appear that cancer could be conveyed from one person to another in this way, and therefore the disease could not be considered infectious." Dr. J. W. Vaughan, in an address on "Some Modern Ideas of Can- cer,"! concludes, in regard to contact tumors and direct infection, that "Surgeons have been removing cancers since the time of Hippocrates, and as yet no case of infection from such a source has ever been observed." Rodman, in an address on cancer read in the section on Surgery and Anatomy of the American Medical Association, at the Fifty- sixth Annual Session, remarks that "The rarity of, if not unheard of, infec- tion of operating surgeons by cancerous patients is the strongest possible evidence against the parasitic nature of the disease."! It would serve no purpose to add to the foregoing the available additional evidence from other sources in support of the contention that in the light of our present knowledge cancer is not an infectious or contagious, or, in other words, a transmissible disease from person to person by contact, or by other means of germ conveyance. If future researches along the line of the admirable work of Roncali into the minute study of the blastomycetes should prove successful, and establish the parasitical origin of cancer, it will no doubt be found that the nature of the organism varies funda- mentally and essentially from the animal or vegetable parasites respon- sible for the transmission of the so-called contagious or infectious dis- eases best typified by typhoid, smallpox and diphtheria. Cancer Not Caused by Worry The public agitation of the cancer problem has aroused opposition on the part of those apprehensive that those predisposed to the disease or actually suffering therefrom may be unduly alarmed, and that those practically free therefrom may be mentally disturbed to the point of hysteria or cancerphobia. The evidence at present available and briefly restated in the preceding discussion should allay the reasonable anxiety *Medical Record, October 11, 1913. ^Journal of the American Medical Association, May 7, 1910. tJournal of the American Medical Association, September 30, 1905. 207 TEE MORTALITY FROM CANCER on the part of the public, first, in regard to the possible heredity of cancer, and second, in regard to the remotely possible but not probable trans- mission of the disease by personal contact or in some more subtle and less readily determinable way. To this may be added the assurance that cancer is not caused by worry, any more than smallpox or yellow fever. Worry has been defined as "the restless consciousness of all encumbrances which we accept under protest." "The fact, however, cannot be too strongly emphasized," in the words of Dr. E. D. Forrest, "that the primary mental condition is one of overactivity, and moreover, over- activity along lines of fijxed ideas." According to the same authority, the physical manifestations of worry in general are "depression of respira- tion, sighing, disturbances in rate and force of heart beat, vasomotor changes, disturbances in secretion, pallor, cold extremities, relaxation and decreased motility of the alimentary tract, dilatation of the pupil, loss of weight, insomnia and general physical exhaustion." Considered from this point of view, it is held that worry may sometimes be an im- portant contributory factor in the production of diabetes, gout, ex- ophthalmic goitre and chronic heart disease. It might seem a reason- able inference that under these conditions worry might also be a con- tributory factor in cancer, but this conclusion does not necessarily follow. Disturbances in secretion, no doubt, might lead to local irritation and thus further the development of precancerous conditions arising out of errors in nutrition; but there probably would have been cancer without worry, as it is conceivable that the disease would have been assisted in its development by mental overactivity along lines of fixed ideas. Cancer and Insanity This question has been quite fully discussed by Romer, of Stuttgart, in a contribution to the "Journal of the German Cancer Society" (1906). Groundless fear of cancer as a cause of insanity is referred to by Romer as having been observed in rare individual cases, but the same argument would apply against countless other factors of suggestion more or less conceivable as contributory causes of mental disease. Romer objects to the public agitation of the cancer problem, particularly on the ground of cancer increase, which, he maintains, has not been proved, nor even made evident as a question of abstract probability. He directs attention to the fear of inheritance in cancer as a predisposing cause of insanity, even though this apprehension is well known to be practically without trustworthy evidence. He also apprehends serious results from a spreading conviction that cancer is a contagious or transmissible dis- ease, but he fails to furnish the necessary statistical evidence that cancer fear or cancer apprehension is taken note of to an appreciable extent as a contributory condition in the admissions to asylums for the insane.* He concedes the great importance of cancer education as a first step towards the possible public control of the disease on the basis of a rational understanding regarding the supreme importance of qualified attention, *Cancer worry or cancer fear is not referred to as a predisposing cause of insanity by Bernard Hollander in hi3 treatise on "The First Signs of Insanity," nor by T. S. Clouston in his work on "Unsoundness of Mind." Other diseases, such as influenza, circulatory disturbances, even child-bearing, exhaustion and fatigue, are mentioned, but there is no reference to cancer or to tumors of the non-malignant type. Charles Mercier, in his treatise on "Sanity and Insanity," and Henry Maudsley, in his work on "Responsibility in Mental Disease," do not mention cancer as a contributory factor in insanity. 208 OBSERVATIONS AND CONCLUSIONS medical or surgical, on the recognition of the earliest symptoms. The danger of encouraging persons needlessly alarmed about cancer to seek the advice of alleged cancer specialists or to place faith in alleged cancer cures, with the increased certainty of fatal results, is well to the point, and deserving of serious thought. He argues that in the main the educational efforts should be through the medium of the family physician of the patient, but the difficulty in this respect is a practical one, in that the vast majority of cancer patients have not the least conception of the extreme seriousness of the earliest symptoms and therefore do not seek the advice of even the family physician until the cancerous growth has reached a stage where the disease has practically extended more or less to the adjoining glands or parts and thus reached a more or less inoperable stage. Romer concludes that the problem is largely one of increased cooperation between physicians and surgeons, on the one hand, and a more perfect mutual understanding and confidence between patient and physician, on the other. The enormous mortality from cancer throughout the world and the obvious increase in the rate of cancer frequency bear witness to the fact that no progress towards cancer mortality control is likely to be made along these very general and rather superficial lines of an understanding on the part of the profession and the public of the menace and the urgency of the earliest practicable removal of the offending cancerous growth. Radium and Radiotherapy A thoroughly qualified statistical inquiry into the results of cancer treatment would make an extremely valuable contribution to the cause of cancer research. A large amount of statistical information has been published on the results of surgical operations, but the methods of statistical analysis have, as a rule, been crude and often not free from serious technical objections. In the case of the non-surgical treatment of cancer the statistical considerations are even more involved, and the conclusions advanced are less to be relied upon as impartial and accurate. The underlying reason is to be found in the widely varying and statis- tically ill-defined principles of medical and surgical practice; in other words, it is extremely difficult, if not practically impossible, to reduce the cases considered to an absolutely comparable basis. For illustra- tion, one institution may treat largely inoperable cases, as a matter of charity or positive necessity; another institution may treat only such cases as upon thorough examination warrant an exceptionally favorable prognosis ; yet the first of the two might actually be better adminstered and yield relatively more favorable results than the second. It is therefore obvious that statistical conclusions regarding methods of treatment require to be accepted with extreme caution. These observations apply with special force to radiotherapy as a possible solution of the apparently hopeless problem of an effective cancer cure by other means than radical surgical interference The subject of radium, however, has attracted so much attention within the last few years that it has seemed advisable to include a brief discussion of it, regardless of the rather doubtful value of the statistical evidence available at the present time. The opinion has been expressed by 209 THE MORTALITY FROM CANCER Mr. A. E. Hay ward Pinch, the medical superintendent of the Radium Institute of London, that "No useful purpose would be served by a mi- nute analysis of the statistics," for, as observed by the British Medical Journal, "the stages and extent of the disease vary so much from case to case that only a very large number would warrant the use of the statistical method." Subsequently, however, some very interesting statistics have been published by the Institute, which will presently be discussed in some detail. It requires to be kept in mind that the modern surgical treatment of cancer is unquestionably much more effective than the surgical practice of the past and that the results ob- tained are in almost precise relation to the previous duration of the disease, or, in other words, to the attained size and degree of infiltration of the cancerous mass into the adjacent tissue through the regional lymphatic glands. The average surgical results, under normal con- ditions, have been summarized by Dr. Isaac Levin, in the following statement : Only in carcinoma of the lip the radical cure by the aid of the so-called block dissection of the tumor and the regional lymph glands is as high as 70 to 83 per cent. In carcinoma of the breast Halstead, who is one of the best operators of this condition, reports that 38.8 per cent, of the cases which were operated remained well for three years and over. Since not all the cases examined were operable, probably not more than 30 per cent, of the cases of carcinoma of the breast can be cured by surgery alone. In regard to carcinoma of the uterus Wertheim, the greatest authority on the surgical treatment of this condition, states that about one half of the cases which come to him are operable and of these about one-half are cured by the operation, consequently about 25 per cent, of the cases of car- cinoma of the uterus may be cured by operative treatment. Wm. J, Mayo, who is one of the most brilliant operators in the world, reported recently on 996 cases of carcinoma of the stomach. Of these 344 cases only were operable and of the latter 25 per cent, remained cured five years and over after the operation. In other words, about 9 per cent, of cases of carcinoma of the stomach can be cured by surgery alone in the hands of a Mayo and probably an even smaller percentage in the hands of most other surgeons. In all rather less than 30 per cent, of cancer patients can hope to be cured by the aid of surgery alone.* It must be admitted that these results are disappointing, considering the high degree of surgical efficiency on the part of those who are right- fully considered the master minds of the surgical profession, but Dr. Levin is far from being justified in his conclusion that "It is also safe to assume that there can hardly be expected any further progress in surgical treatment of malignant tumors," for the self-evident reason that in the past the large majority of the cancer patients obtained sur- gical treatment at a time when the cancerous growth had probably reached the inoperable stage. These observations seem called for in view of the reasons advanced in behalf of the radium treatment as a substitute for surgical interference, even though evidence is wanting to prove that radiotherapy would be applicable to the large majority of deep-seated cancers, which cause the major portion of the aggregate mortality from malignant disease. Radiotherapy is a branch of physiotherapy, which includes treatment by heat, light, electricity and radio-activity. A brief outline of the principles of physiotherapy in its relation to cancer is contained in the treatise on "The Cancer Problem," by William Seaman Bainbridge, who refers to the discovery of Roentgen rays in 1895, which were also 'Isaac Levin, "The Relation Between the Surgical Treatment and Radiotherapy of Cancer," Medical Record, October 10, 1014. 210 OBSERVATIONS AND CONCLUSIONS first employed in the treatment of malignant disease. Elsewhere in this work reference has been made to X-ray dermatitis, or skin cancer, due to the action of the rays, met with among Roentgen-ray workers. In moderate forms of cancer, however, the application of X-rays has been beneficial in treatment, but the statistical data are far from suflScient and conclusive. The discovery of radium and radio-activity by Mme. Curie dates from 1898-1900. The general principles of radiotherapy have been elaborately set forth in a work by Wickham and Degrais, translated by Dore, with an introduction by Sir Malcolm Morris. The therapeutic results discussed in the work are illustrated by a large number of colored photographs of cases before and after treatment. Most of these cases represent external or superficial cancers, and but a few are derived from gynecological experience. In a subsequent treatise on radium, as employed in the treatment of cancer, angiomata, keloids, etc., the same authors present much additional evidence, but again most of the illustrations are of superficial cutaneous cancers, which would naturally be most likely to yield satisfactory results. The statistical interpretation of the facts presented by these and other authors on radiotherapy is as yet far from convincing. The first annual report of the Radium Institute, published in the British Medical Journal, under date of January 25, 1913, includes 657 cases, but of these a large number were not malignant disease. Of the carcinomata and sarcom- ata not a single case was reported as cured ; but out of 447 cases treated, 44, or 9.8 per cent., were reported as apparently cured; 137, or 30.6 per cent., as improved; and 52, or 11.6 per cent., as having died. According to the annual report of the London Radium Institute for 1913, 972 cases were treated during the year, of which 548 were cases of malignant disease. Of this number 1 was reported as cured, but 50, or 9.1 per cent., were reported as apparently cured; 181, or 33 per cent., as improved; and 37, or 6.8 per cent., as having died. A review of the recorded observations on individual cases warrants the conclusion that radium is unquestionably an effective method of treatment in superficial cancers, particularly in the earlier stages of the disease. The results of the treatment, however, are largely dependent upon the quantity of radium used. Failures are more likely to be attributable to the insufficiency in the amount of radium available than to any other cause, at least in patients in a far-advanced stage of the disease. These conclusions, however, apply, as yet, almost exclusively to superficial cutaneous cancers, which cause but a small fraction of the aggregate annual loss of life. There has not been sufficient time to observe the after-effects of radium treatment in a large enough number of typical cases. The statistical experience data have also not as yet been subjected to an extended critical analysis, with a due regard to the organs and parts of the body affected or the specific types of the disease and the degree of cancerous involvement. Nor has the question of joint results in operative and radium treatment combined received adequate attention. There would seem to be much ground for accept- ing the conclusion that the best results, at least in internal cancers, are likely to be obtained, first, by surgical interference, and, second, by subsequent radiotherapy. 211 THE MORTALITY FROM CANCER The practical question remains, however, as to where, under present conditions the required amount of radium is to be obtained, and the out- look is far from encouraging that within a measurable period of time there will be sufficient radium for proper treatment, even in the principal centers of population. The hope for the future lies in the efforts now being made by the United States Bureau of Mines to develop the carnotite deposits of Colorado and Utah, which, it is to be hoped, may- yield a sufficient supply for general use.* Need of an Educational Propaganda Within the last few years the conviction has been gaining ground that the cancer problem is in a large measure a public question of increasing importance. As early as 1891, and possibly before. Dr. G. Winter of Konigsberg, initiated a pubhc campaign for the education of the general practitioner and the laity in the important question of the earhest pos- sible recognition of symptoms, diagnosis and qualified treatment of cancer of the uterus. The principles of a public campaign as laid down by Winter have become generally adopted in similar efforts inaugurated in other countries, not only in regard to cancer of the uterus, but in behalf of a movement for the control of cancer in any and all of its multitudinous varieties. The cardinal principles advanced by Winter are, in brief, (1) the ignorance or indifference of the average practitioner regarding the seriousness of the first symptoms of malignant disease, (2) the ignorance and even criminal carelessness of midwives, (3) the criminal practices of charlatans in advertising cancer cures ;t and (4) the ignorance of the laity. A full discussion of the development of the educational campaign would carry the present work far beyond the original plan and scope of a concise presentation and review of the available statistical data regarding cancer frequency throughout the world. The primary purpose being a collection of trustworthy statistical data essential to the further- ance of efforts to educate the general practitioner and the general pubhc in the fundamental facts of the cancer problem. It has, however, seemed appropriate to include the foUo^^dng brief outline of what has thus far been done in carrying out a program of far-reaching significance, not only to the medical profession, but, in fact, to the adult population of every civilized country in the world. Importance of Knowledge of Early Symptoms of Cancer Suggestions regarding the advantages of a better understanding on the part of the general public of the essential facts of the cancer problem *The statistics of the London Radium Institute for 19 14 are derived from the abstract printed in the Novem- ber 14, 1914, issue of the Scientific American Supplement. The abstract of the report itself is to be found in the British Medical Journal, February 27, 1914. The results of the Radium Investigations of the Bureau of Mines are contained in Bulletin No. 70 of the series of reports on Mineral Technology, published under the direction of Charles L. Parsons, Washington, 1913. The Hearings on Radium before the Committee on Mines and Mining, held on Joint Resolution 185-186, were published as a Congressional document, Washington, 1914. The report of the Committee was issued under date of February 3, 1914, and is published as Report No. 214, House of Representatives, 63d Congress, 2d Session. tMisleading advertbements of alleged cancer remedies and cancer cures are unquestionably the means of a vast amount of injury to the public. In Great Britain the subject of cancer advertisements was investigated by the House of Commons, through a Select Committee on Patent Medicines. The committee made its report under date of August 4, 1914, and recommended, with other instructions, "that the advertisement and sale (except the sale by a doctor's order) of medicines purporting to cure the following diseases be prohibited: cancer, consumption, deafness, diabetes, epilepsy, etc." 212 OBSERVATIONS AND CONCLUSIONS have been made from time to time, but the classical effort in this direc- tion is the work of Dr. Georg Winter, who, as early as 1891, initiated a public campaign against cancer of the uterus in East Prussia. In an address read before the Mississippi Valley Medical Association in 1895, Dr. Theodore A. McGraw, after pointing out that a society called "The League Against Cancer" had recently been formed in France with the object of instituting a crusade against malignant disease, concluded with the suggestion that "Physicians should be better instructed in the means of diagnosis and in the necessity of early operative treatment, and last, but not least, the laity should be induced to assist not only with liberal contributions of means, but also with that intelligent cooperation which would lessen our diflBculties in collecting evidence and making post- mortems and keeping the sufferers out of the hands of quacks." Five years later. Dr. Philander A. Harris, in a brief address before the New York Academy of Medicine, gave expression to the view that "The profession should be educated, and secondarily the- people should become educated, as to the importance of early operation." Dr. W. L. Rod- man of Philadelphia, in a paper read in the Section on Surgery and Anatomy of the American Medical Association, July, 1905, sug- gested that "the public be educated, as they will be in time, to believe that an early diagnosis and prompt operation are both necessary." Dr. Martin of New Orleans, in discussing the paper by Dr. Rodman, endorsed his view by suggesting that "Physicians and the public alike should be educated." At the second International Cancer Conference, held in Paris, October, 1910, Prof, von Czerny, president of the International Association for Cancer Research, laid emphasis on the belief that "the education of the medical profession was essential to the early diagnosis of cancer." Dr. J. C. Bloodgood in an address on "The Surgical Treatment of Cutaneous Malignant Growths," read in the Section on Dermatology of the American Medical Association, June, 1910, reemphasized this suggestion in the statement that it seemed well worth while "to educate the public, and to educate the physician," and that both "should be impressed with the importance of the immediate and complete removal of any congenital mole showing evidence of growth, superficial ulceration, or scab formation." Dr. J. H. Jacobson of Toledo, in an extended address on "The Results Obtained by the Radical Abdominal Operation for Carcinoma of the Uterus," concludes that "The real problems at the present time in the treatment of uterine cancer are not what particular operation gives the best results, but, rather, how such patients can be operated on earlier and how the primary mortality of the radical abdominal operation can be further reduced. The first problem can be solved only by a campaign of educa- tion in our medical schools and in our medical societies, together with some form of public instruction similar to that which has been inaug- urated in Germany by Diihrssen and Winter."* *A3 early as 1802 a Society for Investigating the Nature and Cure of Cancer, was organized in London. Under the auspices of some of the foremost physicians of the period a letter of inquiry was sent out to the principal physicians of England containing thirteen questions, in regard to the diagnostic indications of cancer, the pathological and anatomical nature of cancer, whether a primary disease or a transitional pathological condition, whether inherited, whether infectious, whether related to other diseases, chiefly scrofulous and syph- ilitic, whether affected by climate and topography, whether affected by temperamental predisposition, whether met with among animals, etc. (J. Wolff, Lehre von der Krebskrankheit, Vol. i, p. 81.) 213 THE MORTALITY FROM CANCER Dr. H. J. Boldt of New York, in a discussion of how we may reduce the mortahty from cancer of the uterus, with special reference to treatment and to pubhcity through the lay press,* gives the weight of his endorsement to the plan of public education, in the direction of the dissemination of knowledge regarding the early symptoms of cancer of the uterus through the medium of the newspapers and the periodical press. He remarks that in this publicity work, if undertaken in this country, we would be following "in the footsteps of Germany, where the dissemina- tion of knowledge by similar means was begun by Dtihrssen of Berlin many years ago, and later, on a more extensive scale, by Winter of Konigsberg." He, however, suggests that "more practical benefits would be gained by impressing upon physicians the grave risk of treating with internal or local medication, before having made sure that no malignant condition was present, a patient having even the slightest suspicious symptom," and he, no doubt, is entirely sound in his final conclusion, that "The promulgation of knowledge regarding cancer of the uterus through the lay press, as advised at the last meeting of a large national gathering, cannot bring about a lowering of mortality from uterine cancer to such an extent as would be the case if the medical profession — the family physician — did the teaching directly." Dr. Parker Syms of New York, in a public address on "The Pre- vention and Cure of Cancer,"t also remarks that "Most of our teaching must come through the physician in his practice. If that were well done it would be far better than anything that could be done otherwise in the way of spreading knowledge by literature," but, he observes, "there are some things it is well for the public to know. It is well for them to know that every lump and every swelling is more or less suspicious; they should know that cancer has no definite characteristic symptom which distinguishes it from other conditions. And they should know, also, that a physician can give intelligent advice only after he has made a most careful examination in any case." He draws attention to the possibili- ties of effective aid to be rendered by life insurance companies by the dissemination of knowledge among their policyholders as to how to prevent cancer. He concludes that a public campaign "should not only be nation wide, but world wide; and the more quickly it is started on a uniform basis with good organization the more quickly will it become effective." In an address before the New York Academy of Medicine, May 15, 1913, Dr. Willy Meyer of New York, suggested that "The public should be taught the early signs of cancer," and that "It is to be hoped that by publicity the same results which have been achieved with those afflicted with tuberculosis may be obtained in patients afflicted with cancer." In an address read before the American Gynecological Society, Washington, D. C, May, 1913, Dr. F. J. Taussig considers the best methods of educating American women concerning cancer, advising that physicians should be the prime movers in the organization of societies for the control of cancer, but that the educational work itself should be, as in the case of tuberculosis, left largely in the hands of the laity. He * Journal of the American Medical Association, March 29, 1913. ^Medical Record, May 17, 1913. 214 OBSERVATIONS AND CONCLUSIONS refers to the fact that in 1904, in the discussion of a paper by Dr. Samp- son, on the early recognition of uterine cancer, he had advocated that this work should be done by the American Medical Association; but he had come to the conclusion that "the organization should be under the control of the laity, and only the direction of the work should be in the hands of the medical profession." Dr. W. A. Bryan of Nashville, Tenn., in the chairman's address at the public session of the Southern Medical Association, Lexington, Ky., November, 1913, said that "There is a far greater necessity for instruction of the laity on the subject of cancer than of the medical profession, for in the vast majority of cases of hopeless cancer, hopeless because of delay, we are able to learn that the physician's patience had been exhausted trying to convince a wilful patient of the necessity for action." He adds the further convincing observation that "The consent [to a surgical operation] usually comes after the disease has fulfilled the necessarily very plain requisites to satisfy the dull diagnostic abilities of the patient himself. He [the patient] desired interference only as a last resort, and last-resort therapy terminates almost uniformly in death. The layman must learn certain things he does not know, and must unlearn much that he thinks he knows before his part in the cancer problem can be performed." Public Education in Methods of Cancer Control The first comprehensive statement regarding the salient facts of the cancer problem of interest and importance to the laity is a treatise on "The Control of a Scourge — How Cancer is Curable," by Charles P. Childe, F. R. C. S., Surgeon Royal Portsmouth Hospital, England, published in the New Library of Medicine, 1906. The work includes extended consideration of the conditions under which cancer is curable . or not, with observations on the dread of operation, the first danger- signals, the possibilities of prevention, the urgent need of public educa- tion, the serious menace of alleged cancer cures, the measurable evidence of a considerable degree of success in early operative treatment, etc. A similar work written primarily for the instruction of the public, but of value, also, to the medical profession, is a small treatise on "Preventable Cancer," by Rollo Russell, published in London, 1912. The work includes an extended statistical survey of cancer throughout the world, and some exceptionally valuable observations on the relation of diet to cancer frequency, the temperature of food, the increase of excessive alimentation, and a rough outline of certain supposed factors accountable for cancer occurrence.* Works of this character are unquestionably of great value in stimulat- ing the development of an intelligent but restrained public interest in *Aiiiong recent educational pamphlets on the cancer problem published in the furtherance of the efforts of the American Society for the Control of Cancer, mention requires to be made of the following, issued by the Council on Health and Public Instruction of the American Medical Association: "Control of Cancer," Joseph C. Bloodgood, "Cancer of the Skin," Henry H. Hazen, "Cancer of the Womb," Franklin H Martin, "Cancer of the Genito-Urinary Organs," Hugh H. Young. The American Society for the Control of Cancer has issued two suggestive pamphlets, "Cancer as a Social Problem" and "The Role of the Nurse in the Campaign Against Cancer," prepared by the Executive Secretary of the Society, Mr. Curtis E. Lakeman. An exceptionally valuable publication made available for nation-wide distribution has been issued by the Health Education League of Boston, prepared by Dr. Robert B. Greenough of the Medical School of Harvard University. 215 THE MORTALITY FROM CANCER the many practical questions which require consideration in the further- ance of a public campaign for the control of cancer : the arrest of the per- sistent increase ia the cancer death rate and the ultimate reduction of the appalling mortality from malignant disease. It is, therefore, of the utmost importance that a movement of this kind should be carried forward under the auspices of a National Society for the Control of Cancer, directed by laymen, physicians and surgeons of established reputation, and entitled to the confidence of the general public. Following the public discussion of the menace of cancer during the early part of 1912, the American Society for the Control of Cancer was formed in the City of New York, on May 22, 1913, with the object, as laid down in the constitution, "To disseminate knowledge concerning the symptoms, diagnosis, treatment and prevention of cancer, to in- vestigate the conditions under which cancer is found and to compile statistics in regard thereto." Under the auspices of this society many public meetings have been held throughout the United States, under the immediate direction of local committees appointed by the state or county medical societies, in cooperation with influential laymen and laywomen interested in the cancer cause. The Society has also been instrumental in bringing about a more active interest on the part of the public-health authorities in the dissemination of general knowledge regarding cancer symptoms, diagnosis and treatment, with the result that there has been a vast amount of publicity of salient facts concerning cancer frequency, diagnosis, treatment and cure, on the basis of approved principles in the practice of medicine, to the measurable benefit of the public. The movement has the hearty endorsement of the principal national medical and surgical associations, and the active support of many influential lay persons throughout the nation.* • It has therefore seemed appropriate to include in Appendix H a reprint of an educational circular published by the American Society for the Control of Cancer, and widely distributed throughout the country in the furtherance of its public campaign.! In this direction, then, would seem to lie the only hope of cancer cure and cancer control. To the extent that the public at large be- comes thoroughly cognizant of the true menace of malignant disease, the practical possibilities of effective control become self-evident. Understanding alone, not mere knowledge, is power; and a thorough understanding of fundamental principles, methods and results is nowhere likely to prove more useful and far-reaching than in the vast domain of preventive medicine and public health. The difficulties to be *TabIes 3 and 4, Appendix H. See in this connection the Report on the Health of Portsmouth for the Year 1913, issued during the early part of 1915, pp. 34-37, the Report on the Health of Rochdale for 1913, and the Report of the Metropolitan Borough of Paddington for 1913, pp. 64-68. According to the annual report of Dr. A. M. Fraser, the Medical OflScer of Health of Portsmouth for 1914, there were only 197 deaths from cancer in Portsmouth during that year, as compared with 230 in 1913. It is pointed out in this connection that "this decrease, which occurs in the face of an increase of population, is hailed with satisfaction by the Portsmouth sanitary authorities as justifying their efforts to reduce the cancer death rate by persuading persons who are attacked with this disease to avoid delay and to seek treatment before it is too late for more than palliative measures." Dr. Fraser also reports that from statements made to him by local medical men the publication of circulars and newspaper articles by the health department has been instrumental in inducing a number of persons suffering from early operable cancer to secure treatment, the result of which, it is hoped, will be permanent. fTables 1 and 2, Appendix H. 216 OBSERVATIONS AND CONCLUSIONS overcome are appalling; but the objects to be achieved are well worthy of the most strenuous effort and the not inconsiderable expense. Qualified cancer research into the underlying conditions or circum- stances accountable for the occurrence of the disease must needs rank as a problem of the first order of importance in medicine and surgery; but every branch of science related thereto should derive some benefit from the statistical evidence brought forward in this work for the sole purpose of facilitating the scientific study of what is, what ever has been and what is ever likely to remain one of the most complex problems of human life. The cause of cancer control also should derive some direct advantage from this concise and comprehensive presentation of the truly colossal loss of life throughout the entire civilized world in consequence of the unchecked ravages of malignant disease, and the additional and indisputable evidence that the disease is on the increase, in marked and significant contrast to the decline in the death rate from practically all the other principal causes of death. Aside from humanitarian motives, which in the furtherance of a policy of scientific welfare work on the part of life insurance companies suggests exhaustive inquiries of this kind, there are the strongest pos- sible reasons for believing that a nation-wide campaign for the control of cancer must, in the process of time, prove of direct benefit to life insurance policyholders, as well as to the public at large. In proportion as such efforts are successful, it is obvious that encouragement is given to similar research work into the comparative frequency and observed tendencies of other diseases more or less within the range of prevention and control. Future Statistical Research The future statistical study of cancer gives promise of far-reaching results of great practical usefulness. In no direction are such results more likely to be valuable than in the standardized tabulation and critical analysis of the experience data of large hospitals and private clinics. The mere publication of crude and superficially considered data is, on the other hand, a serious menace to the cancer cause. Entirely too much reliance is placed upon rates or percentages derived from a small number of cases, and, as a general rule, the fundamental law of large numbers, which underlies all qualified statistical analysis, is completely ignored. The value of many an important contribution to the etiology of cancer would be materially increased if the obser- vations were made to rest upon a larger number of critically considered individual facts. The vast amount of institutional experience obtain- able through the records of American and foreign hospitals is at present either unavailable or published in a form more or less useless for practical purposes. The correlation value of such data to the natur- ally much larger amount of mortality experience derived from general or life insurance sources can not easily be exaggerated. To a not inconsiderable extent the future of qualified cancer research depends upon an unimpeachable statistical basis. 217 TEE MORTALITY FROM CAXCER Restatement of Conclusions and Results Mucli if not most of the available statistical information regarding cancer mortality is tentative, and trustworthy only in an approximate sense. E:s;treme caution is always necessary in the use of the data; but in the main it is held that the information can be rehed upon to justify broad conclusions. These, in brief, as deducible from the statistical and other e\'idence presented in this work, are summarized or restated as follows: The first chapter presents in outhne the general principles of statistical inquiry and emphasizes the practical utiUty of the statistical method in medicine and its particular appHcation to the numerous and important general aspects of the cancer problem. Regardless of the inherent diffi- culties of cancer terminology^ exact diagnosis and precise classification, it is held that the statistical method is trustworthy and useful for the present purpose, and in the main at least approximately conclusive regarding local cancer frequency and the observed upward tendency of the cancer death rate throughout the civilized world. In the second chapter the statistical basis of cancer research is further considered, and the need of an even more exhaustive study than the present one is frankly conceded as an essential requirement for a full understanding of all the saHent facts of the cancer problem. The adoption of uniform methods of tabulation and analysis is suggested to registration officials, public hospitals and life insurance companies of at least the more important countries of the world; but even under existing statistical hmitations the official returns for some twenty-six per cent, of the world's population have been utihzed for the present purpose. It is maintained that this vast amount of general cancer mortality informa- tion is in sufficient agreement to warrant the far-reaching conclusion that the menace of cancer throughout the civilized world is much more serious than has generally been assumed to he the case. The problem of cancer increase is considered in some detail in the third chapter, v»-ith a due regard to the ascertained underlying conditioning factors determining local variations in the death rate and the more or less controversial arguments as to the apparent or actual increase in cancer frequency as affected to a variable degree by serious errors in diagnosis or ob\'ious mistakes in death certffication. The conclusion is advanced, and without hesitation, that the evidence of cancer increase throughout the world is an incontrovertible statistical fact, and absolutely conclusive; and it is maintained further that arguments to the contrary are largely in the nature of useless controversies, failing conspicuously in the required evidence of actual errors and defects in the original data sufficient in number to invahdate the utility of the returns as a whole. It is held in this connection that American ^dtal statistics are strictly comparable with the mortality statistics of European and other countries, upon the assumption that absolute accuracy is not necessarily essential to the present purpose, nor attainable under any conceivable existing conditions, also, that the approximate truth as revealed hy the present investigation, in strict conformity to the law of large nunibers, fully justifies the conclusion that the mortality from cancer is increasing at a more or less alarming rate throughout the entire civilized world and that 218 OBSERVATIONS AND CONCLUSIONS this increase implies most serious consequences, present and future, to the populations concerned. Preliminary to the discussion of the statistical evidence in general, the mortality from cancer in different occupations is presented in the fourth chapter, and amplified with numerous interesting and suggestive illus- trations of exceptional cancer frequency in particular employments. It is readily conceded that at the present time the available cancer statistics by occupations are of rather limited practical utility; but it is suggested that thoroughly qualified and highly specialized inquiries in this direction are quite certain to yield important results. Cancer as a problem of life insurance medicine is discussed at some length in the fifth chapter, with a brief historical survey of the mortality from malignant disease in the experience of life insurance companies throughout the world. The data presented fully sustain the general conclusion that cancer is a much more serious mortality problem than has generally been assumed to be tbe case, and that without question the disease is on the increase among life insurance policyholders, medically selected, as well as among the population at large. Of interest in this connection are the suggestive results of the Medico- Actuarial Investiga- tion, especially as regards the influence of overweight on the cancer death rate, the negative evidence regarding the influence of heredity or family history, and, finally, the important modifications in the cancer death rate resulting from marital or conjugal condition. The geographical incidence of cancer throughout the world is briefly reviewed in the sixth chapter, with some consideration of related diseases, such as biliary calculi and non-malignant tumors of the uterus and ovaries. The comparative statistics of cancer by specified organs and parts for selected countries, for which the returns are of approximately the same degree of intrinsic trustworthiness, leave no room for any other conclusion than that practically all forms of cancer are on the increase, but naturally to quite a variable degree. An international comparison of crude cancer death rates for the period 1908-12, based upon the oflicial returns of more than one and a half million deaths for the five continents combined, indicates with approximate accuracy that the highest cancer death rate prevails in Europe and that the lowest rate prevails on the continent of Africa. Cancer mortality is exceptionally high in Switzer- land, Bavaria and Holland, and extremely rare among North American Indians and the primitive races of Asia and Africa. The returns for American states and cities are presented in some detail in the seventh chapter, and the corresponding data for foreign countries are discussed in chapter eight. There is included in these two chapters a brief consideration of cancer frequency as modified by latitude, size of cities and climatic conditions, seemingly warranting the conclusion that cancer frequency decreases with diminishing distances from the equator, or, what is practically the equivalent thereof, a rise in cancer mortality is observed to occur with a diminishing mean annual temperature and rainfall. In the ninth and concluding chapter a variety of aspects of the cancer problem are briefly considered for the purpose of facilitating the practical use and correct interpretation of the numerous statistical tables and 219 THE MORTALITY FROM CANCER forms in the appendices. The primary object of this discussion is to illustrate the extremely complex nature of the cancer problem and the more or less determining influence of widely different and constantly varying special factors and local conditions. The extreme rarity of cancer among primitive races, such as the North American Indian, and the relative infrequency of special forms of cancer among certain types of mankind, such as the comparative freedom from cancer of the breast of Japanese women, are brought forward as proof that even a very low cancer death rate is not necessarily evidence of the intrinsic untrust- worthiness of the returns. These illustrations also throw much light upon the broader aspects of the problem of cancer causation, or, in a more limited sense, the con- ditioning circumstances which more or less determine the local degree of cancer frequency in different countries and locaHties of the civilized world. Precancerous conditions are considered at some length, and it is suggested that a more extended study should be made of the coincident occurrence of cancer and other diseases, chiefly gall-stones, syphilis, leprosy, rheumatism, gout, appendicitis, diabetes and tuberculosis. The surgical aspects are briefly discussed, and with special reference to the at present inadequate statistics of cancer hospitals, which are most urgently in need of standardization, so as to facilitate the comparative study of the results of institutional treatment. It is furthermore suggested that the subject of post-operative results should receive qualified statistical consideration, in that most of the available data are at present of doubtful intrinsic trustworthiness. The same considerations apply to the problem of recurrence, the average duration of the disease, the rela- tive degree of mahgnancy and the rapidity of growth. All of these are important practical aspects of the general cancer problem, whether medicaUy or surgically considered. With regard to heredity and family history, some additional observations reemphasize earlier conclusions that the available evidence in this respect is in the negative. The rela- tion of cancer frequency to overnutrition, metaboHc disorders, vege- tarianism and diet in general suggests the correlation of cancer frequency to overnutrition, as best iflustrated by the statistical evidence derived from the results of the Medico-Actuarial Investigation, that cancer is more common among overweights than among underweights. Chronic irritation as an immediate factor of cancer causation, first considered with reference to occupation, in another chapter, is here further discussed with regard to alcohol and smoking. The available statistical data would seem to indicate that both alcohol and smoking are directly contributory factors, to a variable degree, and particularly so as regards certain organs or parts of the body affected. The extremely important question as to whether cancer is of a parasitical origin, and therefore possibly an infectious disease, is considered at some length, with especial reference to alleged cancer houses, streets, viflages, etc. The available evidence as regards a possible parasitical origin of cancer is held to be in- conclusive. This point is sustained by the vast surgical experience which is without a single record of surgical infection in cancer operations. The available data are also negative on the alleged causation of cancer by worry or its correlation to insanity. Though partly outside of the 220 OBSERVATIONS AND CONCLUSIONS general study of the subject from the statistical point of view, the modem theories of radium and radiotherapy are briefly referred to, with special reference to the statistical experience data of the London Radium Insti- tute. The outlook is encouraging that as regards external cancers the radium treatment of the future will prove productive of much more satisfactory results than the treatment of the past. As regards the effective and exclusive use of radium in the treatment of internal can- cers the evidence at present is quite contradictory and inconclusive. Reviewing the aggregate results of the present investigation, it is shown that cancer is much more common than has generally been assumed to be the case; that the mortahty from the disease throughout the civilized world exceeds 500,000 per annum, and in the United States about 80,000 at the present time; that the disease is increasing in practi- cally all civilized countries and as a general rule in all its principal forms or varieties, and that it is therefore strictly within the hmits of scientific conjecture that a further rise in the death rate may be anticipated, unless the disease is made subject to more effective methods of treat- ment and control. The attainment of this purpose can be brought about only by arousing a world-wide interest in the problem of cancer control, rather than in the strictly scientific aspects of cancer causation, and the development of a sound public understanding of the imperative necessity of early surgical and possibly other interference in place of blind rehance upon more or less disappointing methods of treatment by other means. All of these and many other more or less controversial aspects of the cancer problem urgently suggest the broadening of the scope of statistical research and the perfection of methods of statistical inquiry, towards the end that the whole truth of the cancer problem may be revealed to the immeasurable advantage of the human race. 221 CHARTS 16 CHARTS 1 Q § - - - - M-B- 1 1 o OS _____ -^ ------- II. ;-^ 'A N. ^ Qo --. k:> J^ ^-^ Q>, N ^ p^ v^ g) \, ^ 1 ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ =^ hiiiiiiiiiiilli I 1 I ^ i ^ S"^ -S 1^ S^^g 224 CHARTS t0051>l>X-fiOi— I'Ob-OCOrHCO'OCOC) CO 05 «C 00 i> ooooo!>osoosooooooJ>i>t-»0'*eor-( ? P a t~ 1-1 r-l Ifl <*« 00 O 0» M 1> lO 0» « t~ -# 00 C5 CO « O 0» i-l 05 OS 0» ®» "fl O O t~ -fl 05 O O O O CO O «C_ -#_ 00^ CT_ •*" (sf i-T CO T?" ©f rT 1-H c3 <-l (-> on o o a t^ 1— 1 fU o Li r- on o 'O c Cf) -f< O r-H o CO f-H -* <>« c^ c '* r-< ■* ■* l-H f— ( CO ^ O CO f- f- I-H o t~ M 00 ■—1 o 0<_ C5 ri i-'5 Tfl CO_ « (*»_ O^ -# -* 0_ >0_ 0_ oo* o" o" co" CO •** co' co' o" CO -jl' cf ci" t-' 05COt~t-COrHC5'^t-C5000cOeO fS »r o' o' of of -*«' «5" ■*" c<5 of ^" CO ■* eo" 50 CO t- o « ifl eo M "o ^ r-l i-l S< o» o ^ c fl rv O s ^ -2^^ .2 a CO fl 0? S .- w o 3=5 3— Ci^ — ,g a. o a? 5f o -a ■ft 5n ^ c3 2 c J? 'S O CS -J »-5 a o ?1 u 12; H -i^ d o o rt u u Or-i(Nco^»ocot~oooiO^»teo-*>ocoi>coc5 •g w -ft o '^ s § s s "-^ § . CO «* o 50 CO CO 1-; <3< o -^ 5^<= g- Tji CO CO CO i> o i> i-< o co' ^OjS » S O "^ 1— 1 I— I I— ! ®t I- GO Oi CO a» CO CO 50 »0 CO l> CO CO LO TjH "# CO CO >o •#' so' oi »o "* o o o t-t-t-C0C0C0C0C0*0^^'#'^5'J oo»ffl05©®«^ooi-iOi-i.-ioos»oi>'S'o»>o-*»ci-<»»00»«.-He0t-«£5O5j2 5 o ©< CO CO •* CO ■* i> "^ 'H, *i *^« *- '^.. ^ '^^ - "^ ®i "^^ "^ - »« •^'" I-- i> t> oo" co" co" of co" :s ^^ **' d o a ... a;i 3 CO r-i ^ Q u ®» 00 ©< ^- . t- rH l-H 0» r-1 0< r-l i-( O rH 0< o iO I* ^ =3 CO o3 00 H a CO (2 oo o »« o 00 o t- CO 00 c» o o< CO o oo o i-Oi-HC5j>'«fi"#-fieooo?t-^o 0501051— IC50*000>— isOQOr-l eO>Ci>t~»0'00050C5_'#CO"* orcoi-H'oco'co»oofcjrcoi>co"co J>lO l>00CO00c»t-O«COi— ICOOOOCOOO® Tjl CO >0 05_ C5 00__ 05_ •^^^ 0_ C5^ 0»_ >«__ « '"''„ ^- oi" CO* «5" oo" i-T co" rH i-T t-" -** T-H* of w" io" i-h" oo" of t-" -*" o o«o< t~i-ir-(0«-*i>a tro* CO t~ o '* ^ '—' V 1-H CO Ol CO »0 CO o» ■* O O C5 -# l> O CO •* l-H O O l-H 05 * 'R, 1-1 i> c §" § -2 .S « sjs-s-a^ & a .. ^ fl o tu « 3 4J .3 rt > s =2 3 3 3-2 ^i-HO»eO'*»Qcoi>flOC50rHS»eO'*«ocot-oooso^gM^ o "3 -d -a 225 CHARTS ^ S § ^ ^ ^ ^ \ 1 — \ \, / \ 5j X \ \ k \ \ c^ \ ■ / \ / \ { \ 9? / v> ^- \ H \ - V\ \ :|lli -id III ^ill III III: K^ \ \ } \ ^ \ Iv \ ^ \ f^ \ i\ h \ ft^ \ t ^' ^ ^ 1 1 (*^ \ i 1 \ '^ / fe ^ \ Ol \ \ \ \ \ \ \ \ > V I l5^ \ \ \ \ \ \ \ \ ' >i \ "/ 1 •1 .o 1 \ i( •^ V l\ 1 \ 1 \ 1 1 H. or 1 \ 1 \ 1 1 \ \ A: V 1 / / Nv \ , \ ?? / f> \ \ / 1 I I ?^ ?> ^ ^ ^ ^ § § ^ § 5^ ^ ^ 226 CHARTS »- _r ° 05 OS oi -* i> d 03 o d r-I -*' ■^o^ OOOOOSOlOlOOJOOOO 0000050505O0JOOOO j=aj; oo50i-HrHossooo'00»co> ■g g g so ■* O W5 t- (« OT J> 05_ 0<^ 00 ^ iij^ of of of so" wT ■* •* »*<" TfT lo" »o OOTt»^».'5C5lWl>©*l>0« •*O«C0ai'0O'*<05GC00 ■^t-O5O<_'*i>00_0000O5O5 i--ofao»o«ot--^'-HOO>o"of t- « oi o ^ o* TjH^ o oo_ o^ o»_ g O O O O O O O O O 1-1 ^ i-ii-H r-i '^ 1— 11— (1— 11— (rHi— II— li— 11— II— li-HT— li— (i-H 0,0 j£^t-Ot-;050t3-*t--t-J>ClOO» ■2 o cS ?2 2? S S S£ 5S ZJ 2S S 52 ^' 2 _- ° (N05;DOC050-^0001COi-i» §Pi 000000O1Q0O1O5O5C5C5OO Safe a>^COO>-'5CO-*J>0««0< g2o i-lJ>05^0500r-iO_ Q""u of of of of of of of of of of 00 co" s o < «o«5-*eooO5i-Cl>O3i— lO*"* •^500«i-H^i-^0»OOt~l>0«0 eoof'— i00iooco>0"*coofi-r 0»CO»00'*'0>-*i55-*C5-* to 50 J> l> i> X_ (X 05^ S5_ O^ 0_ 1-1 of of of of of of of of of go' co' go" .-ioi5 o" to* d" d' d" i> t-' x" x" x" oj oT oT cT oT d' -ii l>» ^< Ci 00 00 ^^ GO 00 ^^^ i""* "^T' '^•' "^^ ^i^ ' — ' ' — ' "^J *^J ^^p* '-'^ ^-'^ "^•' •-'-' ' — ' *^^ ' — ' "^^ "^-J ^^^ n «550OXl>X05i— i»000505050500«OOt-J>GOO«©*OJOt-COOGOCO O Oi_ O r-H_ r-< ©*^ GO •<* O^ CC^ «" d" d~ d' d" d' t-" j> t~ i> t-" t-" o6' x o6 0O»OOSt>i— iiCt-iOOJiO-^XOt .- . .. _ _- .. -~ ~ o no I— I «5 Tfl ,-1^ •^ of c> ^ 1> o o» so ifl i-iOXOiOi— i©iO:Ot-XOSO^OJGO'*»0!Ol>X«50i-i©»SO'<«H «XXXXXXXX050S0505050S050505C5OOOOOOOOOOi-l^i-l'-l^ XXXXXXXXXXXXXXXXXXX050i05050505050S05050i0505050 p,o £_socooqso«qsoc5i>t-;©>ct-;io-*;oqooi050> a _- o ^-^QO<35l-^l-ncCQod(^■.*sOT^^d^-Idsoso _;.0 J>X05i-ii-iOJ»COXGOO<05SOiOXO'*>OXX«00»'#SOtPOJ>OSOSO©<0 2'-HiO«5»C«COfflO;CiCOt-t»Ot^t-t-XXXXXXOS05050i00500000 rH 1— I I— I rH i-l r-( «5lOO(0»C0050i-ll>05-^SJ'flO>COX005SO»o'0 05XOO'#^l> JOi-ii-ii*0©<»OXi>0»S»0«-^rtO0»CX05'CiOX^Mi-ii>»0 i-<^ l> ■* G0_^ e< 05^ t> 00 so GO X_ O^ i> •*__ ■^ 05 » CO_ 0<_ rH ^__ 05_ 05 1— I «o o^ »o ©*_ 8> d" cc >o" so" of 00 go" os" 00 so" d' d" »o" so »«" !> d' x" so" j> of xooo5-*oio?i>sox-*oosos;ooo(ic»cixoso i—ie<'*»OOOi-<^-^OJ_OlGOXOO-lSOBO'^>0«OJ>X05050500i— !!-<_,._,„,_ lo »o" »q" ifff »o d d" d" d' d' d' b^ t> t^ b^ t-^ b^ t^ t^ ^^ ^^ t-" b^ i> x" 00 00 x" x" x" x" x" »o «o o< X «0 X « 05 O^ X_ ®^ GO !> x" X" x" «o so »0 1— I o» 0( ® F-iO»SO-<3'«5«Ol>XOiOi-i®(SO-X050.-^0»«0'«JiiOCOJ>XOsOi-iO«00'* XXXXXXXXX05050505a50505050i05OOOOOOOOOOi-l^i-ii-l^ XXXXXXXXXXXXXXXXXXX030505050505050505050505050505 Cq0 05i-do»so'»oo5 •5o'^'*'*'*»C-<*i'*»C'*'*»0»0'J0»0>C«5«5'0«®«0«>t050i>t~r>t-i>XXXXX 2-hO<0!>J>0505»00»J>i-iSOrHi— it-i— iXiOOSt-'^'— i-*O5XiOSO-^«5'>#«50OSOi-l ■S=oi-i©<'*SOi— lOOJi— iCOOl— lt-G0'Si»Oi>O»-Ji-*iS0i>«O5i>i— li— it-lCGOOii-lOt^ s 2 a x_ x_^ x^ r^_^ i-<^ o«^ •* »c >c <-t^ o<^ so^ -* «5 a i-<^ go_^ co o_ go^ i> ro go_ t^ o(^ i> ©<_ go 05^ -* i> o)^ 05 Q ""y of of of go" go" so so" go" go" ■*"'#"*" ■*" •*" ■*" «o "i »c d d' d d~ t-" i> x" x" oT oT os ©■ d" i-<" rt" >CX'*0»X«i«5'fi050©»«005«il>Xi>^50«OSO««5»#l>i©Xi-i'#'«Jib-i-lSO . OC5X«0OXO0<05t-X®0*l>»0S<«>e^-^t-^t-^^^^®f^^sooo■*05lod' t-«0?0?0»C'0»C»C?0?00>#X©<00»CO»o05'0'— ii>SOC3i>'*©<05J>''*0»0 O X^ 0_ ©»_ ■»}<_ » X O^ O*^ ■># i> 05 ^^ ■* ®^ » 1-1 ■* 50 X_^ ^__ •* O^ Oi ^__ ■* i> o^ o»_ «o x^ ^ -^ »o" »o" d" d" d" d' d' i> J> i> i> j> x" x" x" x" os o>" os" 05" d" d' d" d' ^" i-<" rt" of of of of so" so i-iOtSO'*«5?Ot-X050rHO(50'*'»fl?Ot-X050'-iO»SO'3^«5501>X050r-is»sO'* XXXXXXXXX05050105050505050505OOOOOOOOOO^i- X! 1-1 U Q Z "s; « u > a o > < a a •z w a ■i: « of o" o" of -h" '-' r^ ^ 0« CO --l O -f CO » -f ■— I t^ CO CO 'O' -f' CO O O CO r-i C5 !S -f -fi t~ OO "C CO O i-i ^ CO 00 o< >-i (~ i-i CO ^ ^ i-H -rj D -o ^2 d -n 4J 01! c H 1^ « fs a 3 -5 N i 5 I o s ^ o rJl rxi < K rn ^ ._^ -2 5P a 3 2 ft 0» CO 'fi 'O O J> cc &p "2 -^ .t; CO ■-' _ ^ooco!>as i- X'r? O CO O 0 OO" oi J> ■55^ t-5O'*C0C0«0(V»« i.C0<3>i-Hl>OC0O»0 fl«jC0l>Oi-(00-f<^C0 g g CO^ O^ CO^ -p t» o_ co_^ ^ i,oi (sf co" ei" co" <-^ o* o" CO O r-( l-H so <0 CO O O 0> CO 10 O CO 00 00 »i oi ci CO '^ -#COCOO-*COTf(CO eoi-coocoo»-fi •tj*" of co" *f >n r^ co' 5 S r-lOi>CO cS '^ *i js 3 .-. ^ Cfi .s — _5 c3 N a^ t- ■trj so =: .ti .t: M g S O fe c 3 3 a so 3 qHK.:^P-^\ 1 1 1 1 ^ ^ ' ^ o<^ o 10 p 20 O in N ^ cv g jQ \ V ! 1 V •t t V 1 iV 1 \ T .^ 1 ^ N, \ 1 N \1 ^ ^ \ o in in CVf cu <.\j o o in ^ N ^ 230 CHARTS c^ u o § 1) *. ^ ^ O ti •d o 0) -(-> ■01) ^ •ou >> pes Xi CO ^ a; a 03 5 M O •O § ii Wi a s P u C 53 U o a ^ o" " COlOOlOilOO'Ol^ i-H ^S 1>0500«00<«>000 So (3»-*oe<5c<:ioOi-lOO Q-U GO ^ "^ i"^ CN CO 00-^»»050COlt5 o o isi 'o 'o -fi ^ -p rH CO «0 l> I-H 000500C000OC0O ■* i-H 00 O* -fi GO CO 05 'O 'O O O 03 •*' i> t-' 'o" co" V o C0»Oi-ll>i»C0C»'<*i _-ro ooGOiooQOi-iio 1aoPi 1-1 >o CO CO W5 (^rH l-H 0< ©J M t'#oi>5oa> s g fl 1-H o» sj_ o»^ i-H O^ a»^ lo i-H »o CO oT l> !> o ;o CO CO s< '# oq o? o o i> o* >-! i-H o" »»' CO l> 05 OS GO Q-o (DO r=i 59?i »ot~co-^e ijH p^ Q- ^ CO o S :::::: o „ t, -o q^ rtj ^^ ^< ^* "^ ^< ^t M •"l rj I I I I I I 1— I005000COCO eoi-oo©»oo«o of oT "* rH o of oocooJi-Hcdoio i-H CO CO CO «> r-t 0« 0< O5CD'*C000»O?Oi-l i-ll0Q0«O0lO05i-H i-l ©< •^^^ J> i> 00^ Tjl^ 05_ r-T lo" of J> i> oo" I— 'rHO«C0T}(«55Ol> . JH Cl Wl >. ■M ■M (/) ^^ or <\) Wi Pi O ^ 01 +j h !« <:> -l-i y y; a (Tt •o u 0^ ti »« P o ;? -i-i U( cs ^ U >H Oi-;>^i>«o- 05 0< l^ 0< 05 0< ©J T-H -f( 0« ■* O CO rH 00 Oi »» »C «5 CO -* CO o; 00 CO o o »» -"^ CS »o ,_l CO Ol 00 o no «5 Of) »« eo •* »o 1— I CO O Oi c> CO i-< >-< si -* r-; s< Th 00 to rH oi CO si o CO O 00 i-H CO l-l »< UO t- C0C0O5C5C0-^«OO00O00 eorHOr-Jeooi'sioeooo CO 05 O O SI S< CO «5 > «5 ::::::::: o t, -a -rt -i-Hi-HOlcOTfliOOl^S hi^ I o»noic»c«.o»c>o»o hJii;5f-ii-is*s 233 « (H f^ fl p ^^ c3 cj M ii TJ rf^ < O m CHARTS OOOO GO OOOOo' OOicON ^ IT) 'vfK^CVi^ / \ 1 1 1 \ \ \ \ / N \ 1 1 1 1 Q O C) O \, / / / / s v \ V s ^l \ 1 i\ \ \ sf \ \ 1 \ > / 1 \ \ -1 1 1^ 1 \ \ / \ V / / ►0 \ \ v > / 1 1 I 1 \ s \ / / / c c D o o p c :> O) CO ^- ^ 5 p o c ] i ^ 2 c 234 CHARTS ao ^0»e<5>ooq'^T-s»t>ooGiq«5 ©Jso j:aa''^05OT«<5J>t-i»»W5»Ot~i>OOCDS»05t~0»Ci-it-!OOl>CO lOO P 20 C01>«0»0«5»>!>«0}>00050CO>0«OCOCO«OCOl>XOJOSOO J>i-H B'5S®»0"*'— li— i05t~»0<«i— lOll>»CC0i— I05t> S O ^„ '''^ ""1 ''i, © ''^ ®. ''I ®„ *^„ ®„ *i '"*."* *^ ®, ®1 ''^« '^ '"'■* '^ ®^ 05 i-H M-i 3 00" >o '-<' c» Tjf r4' tT TjT o' b-" ®f b-" sf (» SO* 00' t}h' oT TjT 05' »o o" >c 0° in sf f^ a. >OCDi>i>00O5O5O'— li— ISlO^COCO-^'finiOCOCOt-OOOOOS (Nl^ ^■S x,05«»0'*5oeoooOr-i'flcoo-*^05D05i>i-l05S»00 ©»!-l Q g go-U ^"^"^-^-^" coo p & O H ^ W r a COOGOt-50«OCOi-H>eJ(l>000©»»OOt-'#i-IOOtOOOi-aO nT O (S«C«SO-#<0«OJ>050rHCO»C«OOOtOCOr^CX3«OeOrHa>l> 05«0 fci •J3 « rH S» 00 -^^^ »0 © i> 01_ O^ »0 i-<^ J> GO^ 00^ -# O^ CO^ I-H J> (» 05 ■<*< O^ r-l t- Q ^ 1-H t-" eo" 05" >c rH j> GO* oT i» t-* 05 o* o^" go* >o* t-* cc o* i-** go* ■** Ot-OOO^GO»Oi>0©<-*COOOOGO»Ot>05i— IGO GOO •" §■ GO a> 05 05 05 OJ 05 O^ O^ 0__ O O^ i-H__ I-H 1-H ^_^ ^ ©»_ C3< S<_ ©J S< GO GO GO ■# *i CL, pH* rH* rH* T-H* rH* r-T r-T ,-H r-T r-T r-T i-T rH r-T rH* r-T rH O* ®f ^ .-H .-I W W) ! ; « . ; : ^« 03 O : : -^ S • • 1^ Oi 05 ' ■ "^ O 03 t^ t^^ <.AJ ^.^^ \^^ '^U \^J VA^ I.^J V^-i W^ W^ Wi' WJ W*) W.< (h*^ WJ WJ W^ WW WW i>^^ WW - b OCiOiOiOiOiOiOJOiOOOOOOOOOOi— ii— ii-Hi-Hi— I OiO 235 o o *^' $3 CHARTS o O o O CO o o vO o o o o o o o o t I I I ! ^ «5 :::::::: o sj -73 d <55 I I 111 I I H~ I oooooooo I— 'ifJi-IG^WTjllOOt-OO a CO o -2 CO 00 Ji «q i-H 00 ^ »i oj CO «5 ui H O "a S -2 Q -I N o >— ( n. Q Ph o <53 °. Q = «2 « Q la Q l;^ CO C/^ « 00 1—1 CO cS 'O :5 ©» CO 00 > ■«? 05 00 s» 1-5 i> oi ^ PQ z u 2 S 2 o <" X o a° At- ^, D S- O CO O ■ggft, J> «5 lo 1— I .2 O 05 3 3 CS" t> H a =^, ®l o o t- Dh «0 •< « PS ** U 7 o w >H Z r3 O 0.0 j; to CO -^ -i; ■^ i; S- o -*' s< '« l> g •SoPi eo o 'o o " r-l »» CO *« § ^• (V CO t- O gr CO ■* 'Ji lO 2 ■^ eo^ o> eo_^ O^ co" lo" -^ co" to* ---2 00 CO I- ©» o of co" co' co' Pi >c CO o< i-H <>» O OJ -^ »» t> oi oi CO t- OO 0» CO ^ CM CO «» O OS Ci CO i-H i-l l> CO CJ i-H t- t- CO CO CO CO O CO CO t- l-H IC I-H -f. CO I— I -^ CO »o CO 1-H t^ i-T 13^ eo 00 C5 -rfl -f< lO CO o CI o C5 to V p «5 CO I I Its >c CO ■* lO CO Y f "f ^ uo «o o >o CO ■* >-o CO a§ . j> CO Pi" P3 o ' GO i-l (S« i-H '^ 00 l> ■>* CO «5 — a r-, -- *« *» O 00 CO O ■g g g CO^ S*^ OS^ 05_ GO^ l> ©<_ " ■ " ' o' -* o" co' of oo" ■^ rH CO r-l T-H ■^ a o ■3 o a > o-o ft ^ *? '^ So"a° "* CO 8> c3 o a ^ -J ci »o s» CO CO CO CO « cS a a <» cs .3 s 60 X! a; a> ■2 "i "I .- -^ Ph Ph psH cfi O c^ c5 O "^3 ^^3 g a C5 CO 1— I CO ©< ■* i-< OS »o CO aj oi O i-I CO CO CO i> t~ J> t- eo © PS O z -i 2 13 o i-li-IJ>«5»-0 00"* •g g g eo -I Q0_^ 00 i;^.'^ 05 o o s» Q u ^ o» s» s« >o s» 05 ■* i-H 00 CO CO CO 0 O O »0 05 CO ■v >-0 CO r- >o 05 CO 00 fO r- »^ CO f^ in 1— I CO CO 1—^ 1— 1 >— 1 05 f^ xrt^ I-H (V 05 00 CO ^ 05 05 >o 00 Oi (V» f^ 'f 01 T— ( 05 ■^ CO CO 05 CO «5 f- on 05 f^ <^ "* 05 00 1— t GO f- >* f^ (V OJ f^ CO (^ CO 05 <^ «) CO rn ■* tv r-H o< (V CO x* f— ) CO CO CO 01 eo CO SO 00 CO CO CO ■* •* -* •o lo «5 CO CO OrH»»cO'f<>-ocor>coo50'-H(s»eOTfi OOOOOOOOOOi-Hi-Hr-lrHrH OSOSOSOSOiOiOiOSOSOiOSOiOiOiOi 17 ie39 CHARTS % I I I i s^- tm ^ lO t^-io to 'O ^ w fo.^2 ^c^ - 'o, < ^ I I I I = - ' '^ Si \ , \ f> 1 \ S N \ 1^ ■x- ^ I ^ I ^ 1 !Si 51 ^ $! 1 5^ Q '^ -N S 'ti 5^ .s OS (5 A \ "^ u % §1 240 CHARTS go *Sd o -f ■z ^S'pi § < P3 PS- I— 1 ^ Bi p ^ (« I5» 'tl O) u ^ J> -f a, u s o z =: < iiJ t^ IN »^ CO - .'^ 03 o « H a I- crt 05 >* n o '1^ hS o '-' hj < < H OS O rt _• as ns s n^ C. o a OS CO * "^ *"! 'O '~'. OJ 55 Cd o O o -^ ,-H -f< o c; CO -H y—t ^H — "* 'O ;7s CT) '0 -* => -n « '"' CO CO -M -* I- >H P3 rr t^ CO as 'O 'O o 05 CO '^) >o „ — a ■■\ 50 (^ t^ t- f— 1 CO 1—4 o 1^ ■rs Ph o o a •«^ f^ f- CO 1— < I-H 'V 'O w S Q U lO GO «o on ^ ?^ cs CO r». 1^" o -- (V CO >f5 I-H CO "t< CO >^ -^ n^ H u ~ K i^ o f—i r^ -+< -1 o (^ ^H CO i^ s>^: < ffl CO o <- ■^ •o on -)< CO in PH CO CO on -s (^ r-H o CO O W OS X !l d a^ PX CO C35 fi-i o '-0 CO !^ >^ f2 o^ (V o PH O 'V CO o H P3 « § z - < 0.0 |£_COlC>OC0CO-fc ®< ca 5 a O 05 OO CO i-i ,- I- o 1-1 o »o S cS ^ -S TS cS — y a « P5 cfi +; p! cS jj 0^ 0,0 . 05 o a • "SoO- 00 PS- ii ^ § H - < PS a s< 00 1—1 05" CO CO CO ^ -* -# l> 06 06 00 00 X CO 00 »» 05 ®< 1-1 j> 00 00 ®« 00 O CO o< 15* 1— -* o 1— I IC 05 ^ CO 05 ©< CO ©*05G*»ocoi-ii>eos<>o X»Ol>C0i^<5*C0O5 CO'*li-lOOOOi>ocoa5coo5 O5COi><5»CnCOC0O5 O<»>-*l^Q0'^COC0 -# i> 00_^ CO__ s«^ co_^ ©<^ co^ ■•* r-T (^ tC co" »f i-T oT -JiOOS<05C0C0i-l 00i>O'*t^^'OC35 0000 05 C5 05 C5 •^lOCOi>C0050^0o ir -*' »-^ co' "a '^ Oh -* 'i* »» j> I- Oi -f o OS — '"' CO CO r-< CO CO >* en ^ Pi J a s ■* CO fi o •* p— 1 y^ CO o 00 ^ :: c c CX3 00 w -* o x> Oi o 00 oi o» u C8 »» >o ■* »J oo 30 Oi Oi >o 'O u Q u ^ »f co" 1-H sf co" u f-H z 00 •< o u o> m B y-* a a 1> 'p »« i-H t- ij "O a 1-H Oi CO f^ . ij .c >c 05 <0 I-H T? ■9* Oi ir ■«?< o b-i ^ S ^- o CO o T-H s» ^ w_ c- CO CO o o ia 1 3 oo" so" m" 1-" oT f^ >* t- oT co" of rt "" C/J a 1> «5 oo 00 I— 1 M i> o» cc fe Q (» OT 05 «o o^ l> c- Oi l> "-*„ >< Z o' I-' rl ^'' <- '-^ H «!: Ch u s J' V g m ^ > o o c^ 1 t^ 'O i^ -o o a> ■* •* ■<*l fl CD ■^ •* ■>* c s a M5 »0 1 1 1 no CO 1 GO "^ »o o or ^ »iO CO So d o a- •>* '^ d o &i rH d CO Oi 'C CO o ^§&H »> cc [B "So Ph SO l-< 1—1 I— 1 1—1 fri- rt ^ 3 rt-^ li ^ 5C c la rtl c CO ©» o OJ o S QC Q ^ o CO I— 1 s< 00 c^ o X q 5 cr Z: CS g (5) ^ 1—1 co_^ •c t"-„ C/2 o-^^ oc " a < Q"^ o co" '"' i-T '"' m >H 12; g C l§ »fl so Oi OJ o i> ® Oj 0) ° Oh j^ »C' d c d> la < 0* 35 O 3 cr a- c o < li i^ so 00 cc Oi o 00 o 05 u Z 00 o 05 ll a ca CO CO cc " co" 00 1—1 i-T 9i p^ »3 > u a3 60 cS § a 3 o < o H 1 O c« Oh u O a « O > _> ^ -a a CJ ^. ■4-i tn .s o > ■-3 ei ;h i> i> > £- 00 00 30 «2 5a S t - ei ^ .-1 OO •fl ^ ^ OC * ») -* ©» ■* • • Z; o ti 1 c 15 CO ■* lO 05 oo CO T -H C CO 00 « • • g 2 fl t - °„ °°- ® o s» ■^ CO c ■o «.o CO »c C-__ ^ O"" u Q * G * of CO CO CO co' CO ! ■0 GO CO ' co" ■o" S ■* o o: ca H m ^ 1-1 J> so 00 ^ * 1- 00 => • ; 1 _o C 5 "O «o o o l> »c ! o c s o o o 1- :> C 5^ «0 t- ^ oo "JO '^ ! o cc '*" CD ^s- 3 >H 05 S t - -"S*" t- ' 00 05 1> 00 * cc 40 co' * H •"^ "= ;. 5 'T P CO i-H o 05 OS oc C » oc 00 00 » O p -^ *!, '*„ ■* ># CO GO CO C ■0 GO GO CO •o_^ < 11^ fJ' T p ■* ■* •* •* ^'' Tj * ■* " -* tP *" H rt O S Si c 5 ■- H ©» CO •># «5 «o b- C » Oi c f-t < >» CO •«* k"" c 5 C 5 O O o O o o i =■ o 1— 1 >^ c > C D 05 ® H 1— 1 1— 1 03 a> Oi Oi < 3i Oi a Oi < » Oi Oi 243 CHARTS n I I I — 'S^ ^Tt* Nv'^ ' 'I & 5 '^ I ■ ■ - ■ — — C\i to ; ss cj "^ ^ t©'o- <> a ^ j5 B 9i <0 Aj 5 Si <& ^ ^1 244 CHARTS 1- Oi 03 '5J CO CO CO CO -* r-4 1 w ij°.ovi d> o '6 '^ Oi 05 CO 05 00 ■Sofc ^ 00 O i- 0< — < -* 05 i32 =« «* 1-* 00 t- ./^ t. O ^ Ol 00 "^ CO "* J> '-' JJ fl 4) lo CO Ol l- l^ 'O 00 00 CO --I rt 2 O* 'O t-_^ -* J> a OS ^^^3 ^' o oo r^ '6 1> 5§ T 9) a U '- H B!>C5000000 J CO t^ r-l 05 0< 2 cfl 3 0MO51-C0O5 £ |5 13-i o_ o_ io_ o_ -o g "o-3'0 00»0t^ pi, CO o» t- CO t- i-O •* CO^ >J\ "-"^ oi" t-' co" 0" co" O 00 00 -fi >o oo f^ OO" r-T r-T r-T IS* 00 CO l> CO 00 01 >o '-0 03 X" rH r-T i-T H«< S . t4 < i . ^" : : : ^ « : : : ° S fc- • • • "C M 5 05 o> ■* c « S ® S c s •< -O CO '# CD eg "2 7 T ? =* l-J 50 'Ji ifl CO K^ «0 P 00 >* >0 CO ^§ . CO s< ^=. §• CO CO 5^ c . 10 01 1— 1 >— 1 s* co_ g- ^ ^' ^' CO o' .-I ^' m ^ i^gp; «5 ^ ^ ^ PS d ~ , O if5 fC0S • ^ i> ®< _.2 en o Pi £0 »C G^ >-« ■ ^' 0" -1 1> 1— 1 '—1 ^ CO t- 1-1 • o« ^ 00 0-3 05 CO H a "^ c» fs 2 2 ai J = g s Pi -r ^ - 0^ 00 ■ ,-1 T? >o W 00 -w a g i> »o t- '^ °^„ 2 § 2° li ts 0' i-T sf « 2 Z S Q^- J ri f^ < to c t: ■ to a p s 3 &p ;?5 PJ ■^ s 13 O 1/ z > c ^: g « ;— 1 en cS "2 ^ S Sac ^ r M C

ji CO >o 00 >c 05 i> »o sj 06 eo co" 06 o> ■SgpH 05 OJ Oi «n 03 0000000 es w m t.eO'f'O^COOOCO CO t- o< 05 r;; t- ■ o -g g g i> « 0^ 00 <» co__ co^ ^i =* ■* -* »o 'O »0 "C "C 1-1 ■* i-H t~ CO '^ < oo_^ 05 o__ o«_ "O^ CO__ i> to «5 co" co" co" co" g -^ PC .-. B b-COt-T-^lOqiGO g ^^^io«5»OCO !> rt no CO i> CO 1^ 1> i> 00 GO ■B OT i^ S o_ -* 00^ o<_ — oT i>^ oT 00' CO 00" •^'~ •* 00^ o<^ CO_^ "O^ oT "o irT -H CO CO H " 2 lCf-<05C0rT.r-lO CO -# 0< C5 t- 'J' CO 3 g. rH S< 0<_ CO -# "C 10, Ph »0 40' "O "O "o" «5 »0 CO_^ J> C0__ X_ 05_ 0^ rH >o" «5 "O" »0 »o" 50 COC30r-<0*00'* S 0000000 OOO^rlr-Jr-lr-H f 010505050i050i OiOOiOClOiOTO Ph . — ' -1 '"' •"^ 1-H rH r-1 ""^ 245 CHARTS I I I I I r m. I 111 ill i — oi -: I O I Ci, o V5 < s:. 1 "11 H r II w^ is ^ ^ 1 ^ ^ ^ "o CO t^ Irihl 1 U f^^ - III p —i < IIT . 1\ § iru 1 ni 1 1 1 1 1 1 1 M 1 1 1 1 1 M 1 1 1 I i I ! I I I o o o o o o o o o ? \ ■^ Q \ ^ I I o" / i / 1 [ \ 1 1 L_ J J I I ^1 CHARTS to . » co t^ CO CO t- CO "O 'O 00 1 w ?§ o « o -# «6 «o CO C>< l-^ GO 00 < iioCL, ®» O ®« O 'O CO to •+< so"^ 1-1 CO i> i-l CO l- tf- >H PQ n ^ l- "O Oi O CO ^ O 05 'O .-1 n 0» ts g S >-i »» t~ ®, --^^ >0 a» CO C5 O tf >-< 'O CO O 00 2 ©""U rH ■^ l-H of >* 2; ^ «;; rH 05 U '-'3 a!«<30OC30©» J ><) kH -^-J i> -* 03 00 '^ 1 0» l> to !-i t- w-( >0 CO i-i i-< J> »f5 »0 oT -*<" O" QO" 1-h" 1> 05 -fl to -* 1-H 05 I- 'O to >H Si Pfl ■*" 'i*" H < [3 . ^^ . Sh •< ^ : : : ^ . 1-; l> to i-H 05 rH o 'fi •*' i-H oj d 05 "SSPh 03 0« c« m l^oO- ■O --H ®< p;^ r- <5 a m >- 00 .-I ^ ^ 1 a s Q ci o n c i-l O ^ l-H I- 05 ■a a i< Oi a ^ Ol i-H CO t- GO O X! w ■SI ®*., ®„ "*» °°„ r-T CO" ■* r-T I— 1 rH 05 go' a CO 1> ^•2 OS '*! ,°3 oj •* rf^ 5 s=> t- t- 00 • i-H to ©< ■" si si ■ o to rl d oi „ H & 00 lo Q< O •* " '-' PL, to i> 2 rl rH S 2 t^ u pq t 5 a s «: GO 03 -GO -* to o 1 GO J> 0» • I-H o< 00 00 g M »0 03 O fl n o f s oj CO CO "O co' p^ rH ;? '^ 1— 1 fe ^fj C >< w § • 1 o 13 o O << « ^J 73 o U U V 0) t^ in ° H^ a > _a en rt 03 TH ^ (/) rt o o tH o oo' o CO to »C >0 r^ OJ go' 0» «5 ■ggPL, 05000^0^0 c O r-H T— 1 1— 1 «2 ^.■HrH^^,-.^ ^^ T— * T— 1 r-H i-H 03 •^ o< o 00 lo 1> i> S« 0« 05 z « o >-<_ Tf «q^ 00^ r-i^ 0_ 0<^ --H »1 ■* GO 00 O d p°~o «o to to" «r i> j> i> i> J> t- t- i> 00 s 2 o 2 a i>oeotoo5S»»oo5 GO b- rH »0 0> . o «5®<00-*OJ>»000 ®i O 05 t- »C § •.;3 o t- crt o i-^ 50 Oi "o ^- i> »« 00 Tjl ^ OS ^ to lO nrf lO ■* "^ to" oT O) "# t- 03 ®« H '^ 3 l>-#i-l00lC®«O5tO g- rt S< CO c« »* »o_ »o to •* 1-H 00 "O CO S t> X 00 05 o l I- >- I- rH 1 247 CHARTS I { I I I < ■ III to cv igco to v> o^ G.ii ^\; I i^ I I II "Q IS ^ ^ ^ S^ qrr HI I t I I I I i o o o CO O o ^ o r- •v: "< J^ 5 1 -e ^^ •i; ^V fvl c2 i "^ I I 1 I =5 5 1^ 248 CHARTS a a :e per 1,000 op. 34 o oo 11 e per 1,000 op. 3.9 CO oo 00 l^ »« 'O 1-' OS CO CO 'O co' "q 00 Ol I-' -f< r-H i ^-- » •ggPLH (V ») I- r-H oo -f< ^ >o '"' PjS I-H CO Oi 1-H CO l- 2 „ ^ to a^ 2 t. i-H CO 00 1> I-H GO o 03 I-H O CER, 8-1912 Deaths from Cance 5 3'? o . 5 a o O Tjl o a 1-H "5 5.3 oo" -*" o" oo" oi" fc <» •* O GO OJ_ SI h1§ OJ o w Oh cC co" oo" o" o' 00 3,-<005a«01 ^ »o CO rH 0< 00 o; ^a H g. ®» -f< I- -if* -# (N fl o: CO l^ ». o >l Q (£ '^ CO >< z Ph o" of rn" r-H i-h" o" of I-H rH r-( r I-H hi 1 r-( : : : : &3 ii 00 • • • ^ I-H d oo : ■.■t . . o MO Urban. 1 i 60 j^ • • • -O t3 ep t *? § ^ i i i o (J oo ># lO CO u p oo 1 o GO • • -a 05 OS C T ? § o o o -* >0 CO e per ,000 op. 66 1-H ao J? CO o* 00 CO CO •* 0) 5 o O i> 0« O CO O) rtg^ 2J o- c« « lagf^ «5 rH 0« rH F-H p^ i-i '^ Ph 1 *" " ■. o OC Ph a a-Koioooiiflf^ 1-H 3EX Death from Cance; 11 .59 CO _ p:,'53Ho»<»»OOOOCOO< o< cc Q <1 goo OOrHOOO^ IX! ^ CER, B otal Illation < O (U o 0.§ 0, 00 I-H wo • I-H Tf Soi, CO •^ »i ■ d r- «pg2^ 00 ^ I-H Co' o (H CO ^ ^2 "^.SqSojiOOO .000 •aB«0OrHi-H .r-(OJ 1-H O 05 tf 'T' oo U 05 g 2 H c ^ ^ I- ©•"U t- rH oo_^ (»f rt '-' Z '^ P^ < >H u ! '. "i & g : a § E? ^^ o • =3 ?? o ^ tf • o o -o O PL. ^ ^ V cm r^ Id H O kI -H 03 03 s -s '2 -2^ S a 1 g .a g en a 3 ^ Ph IH i. o ^ o C a; jj o E s P ^ aj V !-> ^ PQ c/2 Ph Ph P3 c/: _l o a 00 J> CO «5 O »0 O t-; iq CO O t- •O 05 QO" Oi Oi <5» oo" Co" GO 00 d "«§f^ »> S) »« ®< o« 0«»*©<0*»«0«(X0< «S r- ■" I-H T-( 1— 1 BS Z c3 O (J ,_ 00 l> -* »ocoooo5cos»eooo . i> "O •^ o >0 05i-HCOi>i-Ht-05 »i 0« •<*< ■'Jl to »0 Tfl CO CO CO CO CD-*COO< a ^ i> io_ co__ i-H05CO'*0«0-*<®» >^ § ^ a " c TfT oo" of COOlCOt^I-HUOl-Hi-H H -' g a 'i oo *« t- i-HiOO"#05000000 « §• <5J C^ C0_ ># '^ i^ oo t-J J-' 3 pLH cr o<- " CO CO* eo" COGOCOCOGOCOOOGO ^ rt o S S c < O* CO 'JM lCCOt^00050i-H»« rj ■*' S c c > o o o OOOOOl-Hl-Hi-H r^ I-H ;>. a a ) 03 05 05 H I-H r-H T— 1 Oi a Oi 3^ O O C2 p-t r-H r-H I— 1 31 33 05 rH I— 1 249 CHARTS I I I I I.I.I •b I q "n — I I Hit _ o c3 Sg < = 10- ^ I I I < wo "^ ^ 01 CO to 1 1 ■ < 1 I ■ R B 1 1 1 MM I I f I 1 I o 2 o o o o CO o o ^ o !* o 5! / , a N Ji) . a S ^ I \ Si to ^" 1 >0> ,^ 250 CHARTS ^O -£^ C5 GO CO l> l> 1/5-°'* "-< 2^ "-^ •^ a-- »« CO O CO l^ lO 'f »0 Tfi «5 <5» rH 3< ^ CO O -fi >0 1— I -* -r a^u ja a a; c- ^» m — a o CO 00 O U § sf sT t-" O H o i-l CM CO a eo 5D o „.2 "* "\ ''^ 5 "3 oo" o Iff 0-5 0< O CO H D. ®, «^„ '-' i, -4 oi aS bo D Tf< < -a ^ CO Oi »C J 05 O 1-1 -< =^ --l «l I . . O O CO Cn "5 Oi O ifS S* CO CO »0 CO 00 co^ ®1 "* ^^ of "J*' "* ®» so *» CO --I «ra I— CO CO CO 05 CO «o »o o ^ T3 O 5 •* -f( tP r- CI -o If «p » J5 -a 00 lO CO So CO 00 «5 CO 00 t- 0^ ""^ CO T—i u=i.„o I— 1 fin r^ m >ri »> •j: UO t~ '/^ m ■s§^ »* rH i-< « < p-2 tfi t. »o r» tn kr on Oi 05 CO r^ 00 £ r' <- T-H Q ^ 5 9 8 "O a rx «:i CO r- f- c<: or »o CO c < in Z P3 of a I— 1 on CO < a S so o< 05 r-l '^ 03 CO CO ^Of2 ■* CO »C CO u 3 CO c 1 0) > t d 60 £ a ci 1 > "> to .s r eg 1 n c C J B '^ 1 1 1 as a tr CC 1 ^ Ph f^ cr 0.0 ci©ll:~03!-if-iCOOi>>C»»C0001> i.§-P ©i o< u z 1> 1> ©■"W i-H .-I rH i-l OCOCOCOOO1— l>0(iCO C0COCOCO0000»O'-iCO CO 1> O Oi ■<*O5C0»<00C0O5-*CO eoooo50oocoOi-ico o<&«ot-coococo-^ CO CO 01 OS CO CO >o '^ CO t- CO c 00 CO LO eo CO o< o* tx (V CO CO CO CO CO 'TtH 'f ^ »o CO CO CO eo CO CO CO 00 CO eo CO CO eo H H ;:;;::::;:;;;;; o OT-<0C0050r-l(XCO'* Z OOOOOOOOOOi—PHrHi-Cr-l OSOCSCSOSOOOOSOSOSOOSCSO 251 CHARTS I I I I §1 t^ u.^- In 0-$ C-^ B>, ,^t§, "Q tJS 1 5^ I t^)?. PI !o 10 ^jE; ;r- •^ 2 * ^ o !?i^ Eft cvi i8 5 }D ilLI i I I I I 5; c a: B ^ .5j c- .0 1 .-<; <:>, \ ' » N rS 1 ' Si ^^ [ \ k \ I i a ^ ^ Ml I I I II i252 CHARTS Ck o < m CS o u 2 ^ CO o 2 Sx Oh c>:i So r-< i^ l> 05 'O e<5 -ft lO *« so ^°.- rn » o 'O Tf< «5 »o -* I-H (v oo 'O -t »« h- so *^ o ■SgPH rH CO ■* I-H rM 00 «- m iV on f^ CO ■* on »^ en Ol :2 a s ci o a -ft o c« en GO O Cft) Ol o> 1- o o< CO f^ fV» f^ l>- Q-O I— 1 (« o 00 o >c hJ GO •^ >0 so 05 CO SO »0 •* 5 rft -# "* (- CO -* 'O SO n •Sg^ SO SO P°"u w o S so O « 2 2 Ph < Pi o 515 SJ »» H o. »« so_ Oi ■* ■* CO CO so 05 - = c2 « i22 3ol t^050-*S»CO^ a-ag?i®»G0C0®»i>O5 Q-U S ■>^ UO SO GO CO »» O^ i-H o" of PQ cfi &H pi* W ftO .SO>-lC0O»lOG0t-lt-rHSOa0O5 iooiGO>o>osdcocd©i>c''Oso ■^-^tOlO'O'O'C'OSOSOSOSO tn i.'iJiSROOOGOOOGO-H •gal'<«"*05'001SOSOlO ta g g <» 1-^ »c >o «» so_^ oo_ ■* Q'ilr'^ ?f ^" ^ ^ ^'' ?? ^ -f( •# 00 -# lO 1> 00 O of of 50 -'caOCN-JtWS'OSOC-QDOO^CXi" U »«O»O«CSH ^,_,_,_r-l,-lr-l,-(r-l,-lrtr-lr-lr-lrH 253 CHARTS I I 1 I I i i 111! 0> vjO) '<^ ^ 10 ^ IT) ©N; ra"*^ ■ I 1 .1 Bed ""> I'll 1 II 1 qco 'S O O — Oi ^ s I 1 Si ^ IH (O 'T CO K5 5J'^ vt9, rs iiTi r -' — 1 I I I U 5. ^ 6i 254. CHARTS S n l%a.^.^.^. q CO eo -# CO f-H S5 M «'o-= -*< 00 «c t-^ ■* »o 1— 1 CO -* j> O -SoO^ CO CO CO <*< t- O Tf< CO < tf" >"* eo 1> rt CO CO CER, BY 1912 Deaths from n . 3 00 .-1 OT l-O t- CO 00 00 O SO J ■^ t- •* Oi >o O -# 00 -# OC a eo »o o_ o t- eo 05 CO i> 00 i r-H sf CO" rn" r-: of Z 00 < g O 2 m w ^ ^ W Q J> '# ^ to -# J O CO •* ■* ■^ 3 i-H CO ^ o J> < 05 "Jl 50 CO CO i -:, -* =^ l-_ 1> 1 o_ >o O ■* X - -^ GO CO 1-^ -# fa i> t-' t^" J^-" ®f -* s» t> O i-O S f5 2 "* OS '-* ^ Q ^ §■ t- 'Ji o< >:; z (i< i," rH ph" s< o ffl »o -* C0_ 05 »-0 >* t-' 1-^ ^ o ^ : : : ^ '^ Si lu • • -c t, • • • -d 2 if S ■* ■* ^ ■< .^ .^ ifj ■«ji c flj ^ "^ ^ fi CO 1 03 "2 T ? f '^ ►5 »o »10 i— 1 oo ■* »o "O ^F «5 LO »0 W5 »o CO ^ 50 ■* W5 CO ao • eo oi 4) 5- = «5 «<■ C.O jiqcso>co-^>«i> Ojjo ,-H rH OO' wi d .-H »j ■Sge^ t- t- S m ■gOfc Q, ^ ^ >— ' Pi^ S g «-" ;?^ O! t- ■^ >s a .a a u CO CO CO >-0 I- -SoO^iOCOi- gS^i-iCOOJCO.- O'"0 S<" 1-*" r- I- O 1 SEX Death from Cance 8.R4, G<- Q < fa ir CO 9 co__ i-T CANCER, BY [913 Total Population 11.7.S9 575 C m So a§ d »o i> -^ • ^ C •o Ph ■2of2 05 ^ CO ■ c ^2"^ 50 5 a o O 00 50 • — O) 35 oc " c I— O m 2 < IT lO S « or lO w 00 cj fl ^ t- O v »» §1 • o Q'-O -H 50 of fa u ■ to a i c c8 H § s? ^J o s tlD o 1 O m fa < o oi PL, a > E? > O I c !l Si « a CI ■T3 eg ■y g a "a _ u d « ^ 3 1 s § £ pa (X! PL| fsH ffi _c o _d S J3 ^ T. O e per ,000 op. 00 l-H 110 ^^ >iO ®« 50 CO 00 CO O .-- C CO •^ l-i ^ CO ■^ .-i 05 ®» co" 'j! CO >0 «: w » CO CO CO t- CO t- l> t- i> i> 03 1 ^a| ^ f^ eg O P G<3 t- CO ^ 05 00 o 1-H s» >o 1-1 i> CO o 50 O} t- CO O -Ji (5« >-i O ©< CO c ■^ ■* G0_^ CO lO co__ 05 05^ i-c ©» eo_ I? CO < S fc- ca ^, (5) sT sf sf sT sf ®f ®f eo" eo" co" eo 50 s ^ FRO 10-191 tion o » 05 -, t- -* CO O t~ lO CO o« 31 0» GO ®< ©J rt ^ 00 CO »o CO t- ®l *'- i> 1-H CO i> ■^ o 1-1 eo 00 CO r" 2 "3 o Ho.'*' o t-" co" G< f«| o eo 'J' r* o o ■* CO o: ■^ 05 •* o CO S) Ol i> i> C5 Tfi o 3 s£ ^ t- . *i *i, Ol o O ^ rH Q< 50 ijl CO 00 1 ' 00 CO CO eo -* ^ rji ^ ^ ^ ^ ^ 'J H « O % ^ o si CO ■* i-O CO t- X 05 o -- s» V. ■* 33 ^ c o o o o O O O O rH -H ^ ■^ 2 cr 05 05 1— 1 1— 1 C5 05 0> 05 Ci 1—1 1—1 f* C5 35 C5 C5 c 35 18 255 CHARTS I I I I I i^v. -J < 1 1 1 ITl O^ i?i"l in ^o o Ki 0Q§ |>f! ^(i; 0,0 <^ < Sis- 1 1 o O O o o oo o O ^ "Sh \ 5i 1 1 s V 1 \ Si 1 / V v \ < c c c D 2 c 5 c 5 3 c 3 r ^ 5 ■i o .53 256 CHARTS &2 n O ^ CO S2 Tj. S; '» I- — ' rx • 1 O ?•§§*<« «5 ^ 05 t-^ ■ -fi 00 O -P '-0 c3 o o o ©» Tt< I- o; I- -H o» «5 O ^ CO OO ■< «s I-H >* m «■ n s o : CO o» «o a>03(5* ^•^oooscoisi l> 00 o 0< S» O 05 1— >o >« tf a I-l -* CO t~ 1— 1 I— 1 GO GO «5 i O""" o Z t^ < o -: 3 J CO 00 1> -*005 JlOlOl^COOJCO o CO o »o OOt- ^>O®«'-<'OG0©« >o co__ 00 oo" ci" -*" fe o" 00* co" 'O* t-" go" cfi fi a 6o i> o .-ICO »TjlC005C0 S Q ^ o ®» o« rH O^ »* "-I > Z si s< H -< »3 . t, . . . . . fc. . 1 ., GO : M ^ ■ ■ -o ^ 3) Tjl Tjl -— f *? «oS^ T3-f'-7»r!-:i! ^ 1 GO 1 .ocoP Pgotj-iocohJ oj ?■ S" CO CO c.o.»i505«0'#»ocqq 0) °- o d co' -^ i-H* GO d d ^§s2 ?: «5 cfi „3§^ e< ^ «^ g H PS'- . < J= - 5^ CO 1> Ph t! = i ®< ©< fi,5So®»i>a!'*ioo>ot- S5 = 5 o lO Q "■goOrHrH.-lOOS'-HCO >< w 1' fc- rt I— 1 j£^=i t- rH CO e< cc en >H pq a ^ o -^ GO -< o 0,0 . 00 00 GO • ■ CO GO •"^ 00 GO PS o oz-ocoin-* 1-100 ^2; p2 S "o CO d ;:; ph (N - ©( PS i'^^aSs»'*0 • -co^ 2 o o w 1 C- g O a S< rH lO ;^ «cl a ^ g ■ tn s i S 2 EP o o o «J PS ■^ o fe >< H 3 p^ 3 ^ ^' 2 « 4j f- > .£; J '-^s a -95 g S ^ O ^ U d 4J _J i 1 -g i i -J CQ lifi (Sh PiH P5 c/: o a. J S ■I-' o s-i ^ s' 1- OS q ®»OOl>>0<3 GO to t^ go' d GO dof^ 'J ir «o «5 jfjlfSOCOCOCOCOCOt-t- rt- tf td ■I a § cr d 2 a ©] »r I— 1 ,_, — iJ>t->.O»*-*l>®»Q0GO u CT oo O GooocooicooioeoGOO -« •* »o >O>OCOCOCOt-t~l>Q0O5 s •* 2 a t- t^ • 1> i> COCOCOOCOO'J'OOS^CO ^ 2 -^ »■ t o 00 CO-^OlOOOt^i-OOOS^O o \s 3 ®1 go" ,-1 o c» oo__ co_ o_ -* 00_^ ©»^ co__ d »o d" CO* ®»* d~ i>" 'J"* ®r d H C > ■* CO i>os^©<'J'oo^<-oc;'3< a J 05 C5 Oi C5 O^ O^ O^ q_ r- rH ^_^ ©1^ H^ P-i «!j H pj O S c > r- ■1 s< CO -#»-ooi:~ooc:50t-i©*go-* d C > c > o o oooooO'-ii-i'-i'r'T' r^ r- S O 5 CI S5 Ci O Oi C5 05 02 o o OS l-< r-c .1 1 257 CHARTS I I < O) tin •lr'5 1 3 •3j — - Z H 0 00 05 g g g «5 00 i> '-'. *1 ©•"CJ i-T of ai" »- o »o OJ (-) ID or »-l I— 1 (V ■* t- o GO in ^ 05 05 o <- J^ 00 00 o i-< »4 »» »l 1 1 00 eo 05 'J' «o 00 1-1 l-H ® l» © ■* o »* «o J o o «5 J> so — ooeot-^i^o fn a> (H r-i cc ^ •* 05 o »c o I— I J> I— I "O so CO t- so 1> l> 3» so o "O so ^ ^ '^ ^ f3 t??^ -^t?? o H 13 o Q.O . 00 >c lu S" o <>i I-' •ggpH to OS P5^ © lO 1—1 © ■* © H ft ft 05 03 O •. •« Ph i-i i-| §f^ . O ft c3 o g O) ws 1-; •* i> © © oi so so 1-1 © ■<*< i> © rH i-c 50 I— I <5» i-l So ftg Q. t- © so • 3^° ^ © d • 0) i3 O ^ GO '^ • 00 r-J « «^ S rt S o» -* i> •2 a u © 00 »4 g o CI «r5 © <5^ ©■"(J 00 rH ^ n cj 4J CIS O « J3 cS g _ M !/! Ph fl fl 45 ^ d) u a a ftO . J> © (M © «j 5 o © d © 00 soi-i©©i-j50oo©osi>eo o6di-5oosi>c«>ddr^^ p;;OCO©©©t~i>t-t-i>J>t~ U o ^ § f^ OS H -> < o 5as 00OSiO»Cl>G0C0©S0i— IG01> ©©J>©»»-<*QOi-it-t-X© ©t-oo©<»<_co_©_ 0» 1-1 1— I rH © 1-4 © I- © »0 SO © © © GO (V 1-1 © ^- ^. . . 00 >« (X © © © © 00 00 oo t- «o -3 i>©GO©©o*'Oi>©so©©»»'2oo 2 COt^©SO©©SO©©SO©©GO©© PM e0S0«080S0-*->*-*-^'*'*'*»O"5*'5 t. ©1— llVGO'*»O©t-00©©i— I'XGO'Jt * O©©©©©©©©©"— '1"''"''"''"' ^ O5©©©©©©©©©©05©©© 259 CHARTS ^ s § I i -J < Wo- mr lo CT) jaio ^ !r> I ^ h= 1 iifft 'a > SCO S^ 8j I It O «3 ^ rm I I I I irn in "• •' 0^ >3- ^^ ^ ^ ^^ 1 1 1 1^ ^ '<^ >* ■^ ill 1. II II I 11 Hill IL mil iiiiiiiii I I i I o o o o o OC o ^ o CV! c '^s 1 \ s 1 i / ' i « / !0 1 \ .'i ^ '^1 >4 ^ .0 ses 5) 1 Sk (y ^ a ^ o ?^ Ci •«. ^ t^ ^ 260 CHARTS a§d "C l^ 05 CO i^l C I- "O ^ -0 H o^. o t~ -f OJ ^ C X r;' (- '.I ^ O ^ga. lo IS* -f <>« C-. -f X I- < (ijS ex •« C-. o< -t i- > (Q m t-i^-fi^rsc loooMO'fs • jaSSrWOX*^ ^-fX^I;;- e£ o» t;oa»ooor5?;sii-o 05 ll'^j^ of « -J-" -' ^' K .0' Z S o 3 Q^-PoJfflffl B'^'^^SS ^ 00 -* '-'5 5^ i X i^ '--^ c; 00 o Pi •s X H S •^•■^ t- » 00 '3< -0 g U-; 0-5^ .- x^ o_ "^ -5— cc cT o" x' « fe 'ii 'S >^ t-" i-* en C-' g- c; •* c -0 -* » » '^ I- -0 ^ Q > ^; Ph to i-^ I-*" 1> f-"" '■^ H ■< 13 < . fc- . . . . u . aj . . . o< » "* ©< - §■ ^ s "* ^X ,;,=§*, 0« 0< ^ S< '-' " ^ P- -i m t, I— 1 1— 1 -a a S a :^ Ph as ^Xt-l-iOCO »-H ^ Ci,:£gJj>coi>i>x CO X G rtoc cooo^ci » ? C3 ^ ^ Z ^^^ ^' ^- ^ > T) Z t-o „ O^ X = X U D.§ ,£_ r-l »0 ^ • O^ «5 _.2 .-<^ i> 2i io'P -*' r-I i-H • CO = ■3 50 t- r- a C5 3S^ ^ 'i' ®« 9< -j; ©» ^2 ^' « O' < o O! ei-2^lsSgi§g :^ cs 2 , , ® CO ^ 00 Hri g£c»i>05 1— ' § o g 2 0"-*-d - '^ [>< < S c3 >* (J * « H . g s ^ 60 S 3 SXi ^1 C o i> " ^ 'ill 3 .s s to ■§ 0. 01 B 3 w _aj 2 ^ w s 4^ ^ g ee 3 c t: "^ It u •a a II i i • c a s « ^ &H fc, p: C.O ■ CO » X eo ©» C5 '-OX » • u •£So-*«>Clr^t-030ffl-*0<^>0 1> z = c eo o« 1-0 t> X 0^ i-H^^ ^__ x^ rH 5< ^ Q'-CJ '**' "* "* '*'" '* ^' "^^ ■* '^'' "^^ '-''^ "*" J-O ■-0 S ■* o C! a ».ocixt-co>-o-*cos«'^os5 s« »o •^ 2 [-01>-*<'-lOO»-0 0 -+ PH o • ■- CO o< X "-O Ol X "O ®« (» i-o^^ o<^ x_ LO ■3* o >- C5 ■3 >o -* co' sf 0' cs" x" 0" "O' •*'" 'Sj' 0. .-l-fiTfi^-*-+"C0COC0COCOCO f— < c H •"* CO CO «C 10 "O lO 10 "O 'O^ •0__ 10 'O^ '0_^ 'ro LO lO ^ ■*" ■*" ■*' •* -* -p •*" ■* '*<' •* "* •* •* ^'' s OOOOOOOOOOi-i^ l-H r-» »— * .- C5C50>C5CiC5ClCiCJOC5C5 C5 e: c: K-l r -< r -1 f-l I— 1 I— 1 I-l "— ' ri rH 261 CHARTS I I I l^r\l . J . m EH -- lo 05 ho o — CO 4,w ci . a —No 111' I « lit T <.. I < H II I LI I I iimi I • ^ !*^ ^ * ^ v^ xS (0 i i« «o i^j: en •* ic ■* ■* •* i^* w ^- »,- af O W O rf] o i> i> 05 «0 «0 50 "Jl OT i-T ■■* rH to CO »» — I t- * d r-5 d S fl 0) GO 00 05 03 O P CO ^ 00 ©""u eo" S 60 4J 1 > ^^ to CO *J ^ 4-3 n ■p S « S g ^ r M J; o fl 4J S 5 P "S 3 S ^ P3 cfi Ph c a J? a fi< m E« o ^^ o S I grtOOrHi-H-^eooooi-HCOift-^usOi-; 0«- 00 r-4 eo^ J> (N •*" ^ -"S? >o «i"»eo«o0!0i-i«50 •^"^■^O00Q0 !-H 00 i> t- o CO to lo CO t- 05 i—l I— I CO O ©»^ eo__ oi_ d" CO ^^■*«5»O»O«OCO«5«Di>t-00C0 o i-H o« eo ■* o o o o o t"OOOs©'-''»*cO'* OOOi— ii— ii-Hi— It— I SroO505OS0Sa5O505O50505®222 ^^pHi- U >n GO CO CO O a CO H fi <1 3 Ph o P^ a h- 1 CO ffl J3 ^ o ^ •-s H 1 ^ W § C< H ^ < ^ flH el Ci:i a Q (£< ►^ i-i <1 u u c HH « o O tf 5 S? S* 'f ^ -; CO d 5j rH s< o< fc^t OJ i^ CO o< CO (V «o si a <0 W C/2 P-l ™ d Si PQ CO O a (» o u Si •*f S o H ^ H g H tf *3 < S 00 00 Ph u 6 o« W S ■"* r-l Q PL, hJ < U hH O o h-? P4 o H ^ CJ S I5: ■0 ^ >H o o o 265 APPENDIX A Tumor Classifications Table Page 1 Walshe's Classification, 1844 268 2 Pembrey and Ritchie's Classification, 1913 269 3 Hatch's Classification, 1904 271 4 Charles Powell White's Classification, 1913 272 5 Gould and Pyle's Classification, 1914 273 6 Bertillon International Classification of Tumors 276 7 Bertillon International Classification of Diseases Allied to Tumors 281 8 Imperial Cancer Research Fund Classification, 1903 283 267 APPENDIX A w > c o fi Spongy or ossivorous tumor. Ruysch. Pal- letta. Struma fungosa (testis). Callisen. Spongoid inflammation. Burns. Milt-like tumor. Munro. Medullary sarcoma. Abernethy. Cerebriform disease or cancer. Laennec. Pulpy testicle. Baillie. Carcinus spongiosus. Good. Carcinoma spongiosum. Young. Fungoid disease. A. Cooper, Hodgkin. Medullary fungus. Maunoir, Chelius. Acute fungous tumor. C. Bell. Medullary cancer. Travers. Cephaloma. Hooper, Carswell. Carcinoma medullare. Mueller. Soft cancer. Auct. Var. Carcinomatous sarcoma. Abernethy. Carcinoma scirrhosum. Young. Scirrhous cancer. Travers. Scirrhoma. Carswell. Carcinoma simplex vel fibrosum. Mueller. Stone cancer. Auct. Var. Areolar gelatiniform cancer. Cruveilhier. Carcinoma alveolare. Mueller. Gum cancer. Hodgkin. Common vascular 1 sarcoma 1 Abernethy. Mammary sarco- ( ma? j Solanoid. Recamier, Zang. Nephroid. Idem. Napiform. Idem. Carcinoma fasciculatum vel hya- linum. Mueller. Fungus hsematodes. Hey. Hsematode Cancer. Auct. Gall. § ^ is si »^ S J^ [ Pultaceous cancer ] Colloid < Pearly alveolar [Cruveilhier [ ditto j a Encephaloid ■ 1 '0 m snu9Q 'BraoupjB;^ JO J99m?3 jgpjQ sgnssij^ SSB|3 suoi^j^rajoj sno§opj9:j9jj i^^iraB^ suol:^'BraJO^J snopi:^u9Apy 2()8 APPENDIX A Table 2 Pembrey and Ritchie's Classification, 1913 A. TUMOURS ORIGINATING IN POST-NATAL LIFE FROM NORMAL TISSUES OF INDIVIDUAL Innocent Tumours Intermediate Types Malignant Tumours 1. Epiblast: Skin epithelium Specialized epi- blastic structures (e. g., breast): Skin epithelium Pigmented epi- thelial structures Nerve tissue Germinal epithe- lium 2. Mesoblast: Connective tissue Primitive connec- tive tissue Fat Specialized meso- blastic structures: Pigmented cells Bone Cartilage Muscle Lymph spaces Lymphatic tissue and blood-form- ing organs Hypoblast: Intestinal mucosa Special hypoblas- tic organs {liver, pancreas, thyroid, etc.) Papilloma Adenoma Glioma Ovarian cyst Fibroma Myeloid sarcoma Myxoma Lipoma Certain pigmented tumours in animals Osteoma : ebumat- ed (adamanti- noma), cancel- lous; odontoma Chondroma Leiomyoma (fibro- myoma) Lymphoma Myeloma Hypoblastic papil- loma Adenoma Simple cystic epi- thelioma Rodent ulcer Basal-celled car- Adenoma Proliferating pap- illoma of ovary Keloid Recurrent fibroma Endothelioma ? Certain cutane- ous sarcomata EpitheUoma. Carcinoma. Melanotic carcinoma Gliosarcoma. Carcinoma of ovary. Sarcoma: Spindle-celled. Round-celled. Small round-celled. Large round-celled. Mixed-celled. Myeloid sarcoma. Myxosarcoma. Melanotic sarcoma. Osteosarcoma. Chondrosarcoma. Endothelioma. Lymphosarcoma. Chioroma. Leukaemia. Malignant adenoma, carcinoma. Carcinoma. 269 APPENDIX A Table 2 (concluded) Pembrey and Ritchie's Classification, 1913 B. TUMOURS ARISING FROM ERRORS OF DEVELOPMENT Group 1. — ^Tumours arising from junction of two embryos or from a process analogous to formation of monochorial twins — in either case from cells usually having the capacity of forming more than one embryonic layer. From, Somatoblast: Includes many varieties from (a) union of two more or less perfect individuals — e. g., Siamese twins — to (b) one complete individual plus elements of another (teratoid dermoid cysts, teratoma). From Trophoblast: Chorionepithelioma arising in an otherwise perfect maleorfemale. From, Combined Somatoblast and Trophoblast: Usual form — dermoid cyst plus chorionepithelioma. Group 2. — Tumours arising in later embryonic life from displacement of cells which usually are already so far differentiated as to be capable of forming only one type of adult tissue. Innocent Tumours Intermediate Types Malignant Tumours From epiblast Inclusion dermoid __ Malignant develop- cysts ments in dermoid cysts, branchial clefts or other epi- thelial embryonic remains. Special organs ? Suprarenal rests — ? Suprarenal rests. Neurocytoma — — Neurofibrilloma — — From mesoblast: Bone Osteoma — — Cartilage Chondroma (par- otid, testicle) — — Muscle Rhabdomyoma (heart, kidney) — — Bloodvessels . Angeioma — Angeiosarcoma. Lymphatic vessels Lymphangioma — Lymphangeiosar- coma. Mixed mesoblastic — Certain kidney — elements tumours From combined epi- Nsevi (moles) Mixed tumours of Epithelioma 1 devel- oping from blast and mesoblast parotid Melanotic sarcoma Melanotic nsevi. carcinoma C. PARASITIC TUMOURS ARISING FROM TISSUE OF EMBRYO BEING GRAFTED ON MATERNAL ORGANISM Innocent Tumour Intermediate Type Malignant Tumour Placental mole Chorionepithelioma Chorionepithelioma 270 APPENDIX A Table 3 Hatch's Classification, 1904 THE TUMORS AS DISTRIBUTED AMONG THE FIVE PATHOLOGICAL BLASTODERMIC REGIONS OF THE BODY I. Epiblast. — Epithelial hypertrophies, (corns, horns onychoma) dermoids, papil- loma adenoma, papillary adenoma, hy- groma, odontoma, lupus, squamous epithe- lioma; with exception of Cancer of Breast, all benign and non-metastatic. c« »■ -a l— 1 +-1 t« is •M S4-I id o n , 1 u o <4-i Ui >» •M o VI u O a; T-! bD fl .s 3 0) -d d O c3 ^ c3 -a a § o o 1=1 ^ Benign or non- metastatic. II. Parietalor Bodily Mesoblast. — All (benign) tumors of connective tissue substances, viz. : fibroma, lipoma, myxoma, osteoma, chondroma, osteoid chondroma, neuroma, and the non-metastatic sarcom- ata (myeloid and both forms of spindle- celled sarcoma and glioma) . (See foot-note.) III. Genito - Urinary Mesoblast. — Leiomyoma, rhabdomyoma, myofibroma, cysticadenoma, ovarian cysts, sarcomata of various kinds and tubercle, but all non- metastatics in this region. IV. Visceral Mesoblast. — Angioma, lymph-angiomaandlymphoma(suspicious); generalized sarcomata (melanotic) alveolar, lymph-adenoid, and round-celled, and tubercle; all malignant and metastatic, except the two congenital new-formations, viz. : angioma and lymph-angioma. V. Hypoblast. — Adenoma and cysts (suspicious) cancers, viz. : cylindrical epithe- lioma, soft and hard cancers, very malig- nant and metastatic unless they become colloid; (no papilloma in this region). Benign or non- metastatic. Benign or non- metastatic (even tubercle is so in this re- gion, viz. : usu- ally local). (Home of Tuber- cle) Malignant generalized and metastatic tumors. Malignant and metastatic. From the above it may be also fairly suggested that the visceral mesoblast originated from the hypoblast. (Foot-note). The round cells sarcomata apparently found in this region do not strictly belong to this region, but to portions of the visceral mesoblast, which are surrounded or covered by the parietal mesoblast, as in lymph-glands and vascular system. 271 APPENDIX A Table 4 Charles PoweU White's Classification, 1913 CLASSIFICATION OF TUMOURS A. Organomata, or Organ Tumours. 1. Teratoma. B. HiSTiOMATA, or Tissue Tmnours. a. Desmomata, or Supporting Tissue Tumours. 1. Myxoma. Mucous tissue. 2. Fibroma. Fibrous tissue. 3. Lipoma. Fat. 4. Chondroma. Cartilage. 5. Chordoma. Notochordal tissue. 6. Osteoma. Bone. 7. Odontoma. Dentine. 8. Glioma. Neuroglia. h. Neuromata, or Nerve Tumours. 1 . Neuroma. Nervous tissue. c. Myomata, or Muscle Tumours. 1. Rhabdomyoma. Striated muscle. 2. Leiomyoma. Smooth muscle. d. Lymphomata, or Lymphoid Tissue Tumours. 1. Lymphoma. Lymphoid tissue. 2. Myeloma. Bone marrow. e. Epithelial and Endothelial Histiomata. Papilloma, Adenoma, Angeioma. C. Cytomata, or Cell Tumours. a. Blastocytomata. Indifferent cells. h. Sarcomata (Desmocytomata). Supporting tissue cells. c. Neurocytomata. Nerve cells. d. Myocytomata. Muscle cells. e. Lymphocytomata. Lymphoid cells. /. Carcinomata. Epithelial and endo- thehal cells. 272 APPENDIX A Table 5 Gould and Pyle's Classification, 1914 TUMORS, TABLE OF Name Histologic Constituents Physicai. Manifestations Seats of Predilection Adenoma 1. Acinout 2. TuhuUiT Acini lined with spheroidal epithelium, with varying amount of connective tissue, as in a normal gland. Tubules lined with cylindrical epithelium. Firm, rather hard consistence; inelastic; lobulated; light- gray or slightly yellow color; movable; encapsulated; gen- erally single; rounded; when on mucous surfaces, flat and irregular. Soft; frequently pedunculat- ed; grayish- white or reddish color; translucent. Mamma, lip, ovary, testis, prostate, thyroid, parotid, lacrimal gland, sudoriferous and sebaceous glands. Rectum and other portions of intestines; uterus. Angioma 1. Telangiectatic 2. Cavernous Dilated blood-vessels. Spaces lined with endothelial cells and filled with blood, like corpora cavernosa of penis. Large epithelial cells contain- ing one or more nuclei, with- out visible intercellular ma- trix, grouped into acini (can- cer-nests). Vessels have walls of normal thickness and con- stitution, and ramify in the stroma, and not among the cells themselves. Three varieties are described histologically: (a) squamous, made up of squamous or flat epithelium; (6) cylindrical, containing columnar cells; (c) glandular, composed largely of polyhedral cells, like those of secreting glands. A form of round-celled sar- coma {which see). Surface often covered with small, granular elevations, resembling a strawberry; often well circumscribed. Soft, doughy; non-pulsating; leaden or blue color. Skin, mucous membrane, brain, bones and mamma. Liver, kidney, spleen, uterus, bones, muscle. Carcinoma 1. Scirrhous (hard, spheroidal-celled) 2. Encepkaloid (soft, spheroidal-celled) 3. Colloid (probably a degeneration of one of the preced- ing varieti!)( |> N 'ttO ' I. - .o 1-1 (N .i-l rHi-KNM '"H ++ + + ++++ + P :^ 5«s T-lrHCOtO •s-SbSSsilas-dgMgls o S s* o >>J=)P «s 1^5 S 1^ « o ^ § o S =« «5 uj^S 1 T . . . ! ; ! . -Tji .ON + + ++ on ._, . .-« TjH iHCOt>« MIMiOCOint- S ■ . • --ilM S^M I I I + + ++ ++ + 05C<|^r-l.-liMrH ■ -COi-l -i-li-lrJlTjl 0>05'^ APPENDIX B + + '+ '++ ' '++ ++ •Tf .M-<-H C^l -.-Ht^ CO • •«>!« d s* >MC ® C O •■•- C QJ-- 3 < !- ti 3 ; P30a2h Pa_6« SflSS a'? a fi 5 t- v;, ID t, e 113.5 170.5 57.0 Maltsters 109.1 101.6 - 7.5 Quarrymen 107.0 91.2 -15.8 Fishermen 101.0 111.9 10.9 Butchers 97.2 102.8 5.6 Glass-workers 96.7 100.9 4.2 Innkeepers 93.1 108.8 15.7 Physicians 91.4 101.1 9.7 Lawyers 89.7 111.8 22.1 Tobacconists 87.0 95.4 8.4 Metal-workers '... 85.3 101.1 15.8 Coal-merchants 84.8 85.7 0.9 Hatters 84.3 101.0 16.7 Shoemakers 83.1 103.2 20.1 Corn-millers 82.6 105.3 22.7 Domestic indoor servants 81.8 93.2 11.4 Carpenters and joiners 80.3 97.6 17.3 Bakers 78.9 99.3 20.4 Printers 77.3 92.9 15.6 Tailors 76.5 112.9 36.4 Textile-workers 75.3 112.6 37.3 Farmers and graziers 72.9 94.8 21.9 Railway engine drivers and stokers 72.6 85.3 12.7 Ironmongers 72.1 87.0 14.9 School-teachers 71.2 90.1 18.9 Gardeners and nurserymen 69.2 85.2 16.0 Clergymen 67.3 87.3 20.0 Farm laborers 66.6 79.7 13.1 Tanners 64.0 78.2 14.2 Potters 63.8 91.0 27.2 Coal-miners 61.4 82.4 21.0 Grocers 58.0 76^5 18.5 Source: Supplements to the Fifty-fifth and Sixty -fifth Reports of the Registrar- General of England and Wales. (1881-1890. Vol. II., and 1900-1902, Vol. II.) 812 APPENDIX C Table 6 Industrial Mortality Experience of The Prudential Insurance Company of America Mortality from Cancer by Occupation, Ages 35 and Over, Males, 1907-1912 Deaths from All Causes All males (35 years and over) 133,175 All occupied males (35 years and over).. 121,637 Unoccupied Males 7,107 Retired 4,197 Farmers and planters 5,589 Gardeners 1,210 Fishermen and oystermen 255 Coal-miners 2,171 Potters 216 Glass-workers 368 Marble and stone- workers 675 Clothing-workers (tailors) 1,748 Hatters 411 Bakers 901 Millers 173 Iron-moulders 1,004 All other iron and steel- workers 2,657 Ship and boat builders 227 Wagon-makers and wheelwrights 422 Harness-makers 322 Tanners 266 Brewers and maltsters 225 Upholsterers 237 Sawyers 183 Coopers 643 Jewelers 282 Tinsmiths 596 Papermakers 164 Bookbinders 143 Printers and lithographers 1,103 Textile-workers 1,651 Cigarmakers 838 Electrical workers 418 Rubber-workers 132 Blacksmiths 1,782 Builders and contractors 537 Carpenters 6,478 Masons 2,088 Painters 3,445 Paperhangers 191 Plasterers 507 Roofers 200 Shoemakers 2,073 Boxmakers 129 Engineers, not specified 1,797 Firemen, not specified 670 Foremen, not specified 655 Laborers, not specified 28,949 Machinists 2,367 Mill operatives, no'v specified 903 •eaths from Per Cent. Cancer of All Causes 7,295 6.48 6.756 5.55 320 4.50 211 6.03 388 6.94 102 8.43 17 6.67 81 3.73 5 2.31 21 5.71 36 6.33 131 7.49 16 3.89 57 6.33 6 3.47 54 5.38 134 5.04 17 7.49 30 7.11 19 5.90 16 6.02 13 6.78 20 8.44 14 7.65 39 ^1.07 23 L\LES Number Aggregate Average Number Aggregate Average Organ or Part of Years Age at of Years Age at Deaths of Life Death Deaths of Life Death Buccal ca\nty 89 4,493 50.5 Stomach and liver .... 860 44,280 51.5 179 9,064 50.6 Peritoneum, intestines and rectum 274 13,343 48.7 95 4,586 48.3 Female generative or- gans 264 12,214 46.3 Breast 3 lei 53.7 118 5,479 46.4 Skin 32 1,607 50.2 5 259 51.8 Other organs 354 17,049 48.2 70 3,180 45.4 Organs not specified . . . 51 2,490 48.8 .50.2 33 764 1,512 45.8 All organs 1,663 83,423 36,294 47.5 346 APPENDIX D Table 22 Ordinary Mortality Experience of The Prudential Insurance Company of America Mortality from Cancer, by Organs and Parts, according to Sex at Divisional Periods of Life 1886-1913 MALES AGES UNDER 35 No. of Per Organ or Part Deaths Cent. Buccal cavity 4 2.8 Stomach and liver 43 30.3 Peritoneum, intestines, rectum .. . 32 22.5 Female generative organs Breast Skin 2 1.4 Other or not specified organs 61 43.0 All organs 142 100.0 AGES 35-44 Buccal cavity 23 6.8 Stomach and liver 162 48.1 Peritoneum, intestines, rectum ... 62 18.4 Female generative organs Breast Skin 7 2.1 Other or not specified organs 83 24.6 All organs 337 100.0 AGES 45-64 Buccal cavity 57 5.6 Stomach and liver 571 55.7 Peritoneum, 'ntestines, rectum . . . 155 15.1 Female generative organs Breast 3 0.3 Skin 22 2.1 Other or not specified organs 218 21.2 All organs 1,026 100.0 FEMALES No. of Per Deaths Cent. ii 16.2 10 14.7 24 35.3 9 13.2 1 1.5 13 19.1 68 100.0 38 16.4 27 11.6 89 38.4 42 18.1 36 15.5 232 100.0 lis 26.6 53 12.3 148 34.3 62 14.3 3 0.7 51 11.8 432 100.0 347 APPENDIX D Table 22 (concluded) Ordinary Mortality Experience of The Prudential Insurance Company of America Mortality from Cancer, by Organs and Parts, according to Sex at Divisional Periods of Life 1886-1913 MALES AGES 65 AND OVER No. of Per Organ or Part Deaths Cent, Buccal ca\aty 5 3.2 Stomach and liver 84 53.2 Peritoneum, intestines, rectum .. . 25 15.8 Female generative organs Breast Skin 1 0.6 Other or not specified organs 43 27.0 Allorgans 158 100.0 ALL AGES Buccal cavity: 89 5.3 Stomach and liver 860 51.7 Peritoneum, intestines, rectum . . . 274 16.5 Female generative organs Breast 3 0.2 Skin 32 1.9 Other or not s|)ecified organs 405 24.4 All organs 1,663 100.0 FEMALES No. of Per Deaths Cent. 15 46.9 6 15.6 3 9.4 5 15.6 1 3.1 3 9.4 32 100.0 179 23.4 95 12.4 264 34.6 118 15.4 5 0.7 103 13.5 764 100.0 Table 23 Ordinary Mortality Experience of The Prudential Insurance Company of America Mortality from Cancer at Divisional Periods of Life, by Organs and Parts according to Sex 1886-1913 MALES BUCCAL CAVITY No. of Per Ages Deaths Cent. Under 35 4 4.5 35-44 23 25.8 45-64 57 64.1 65 and over 5 5.6 Total 89 100.0 STOMACH AND LIVER Under 35 43 5.0 35-44 162 18.8 45-64 571 66.4 65 and over 84 9.8 Total 860 100.0 FEMALES No. of Deaths Per Cent. 11 6.1 38 21.2 115 64.3 15 8.4 179 100.0 348 APPENDIX D Table 23 (concluded) Ordinary Mortality Experience of The Prudential Insurance Company of America Mortality from Cancer at Divisional Periods of Life, by Organs and Parts according to Sex 1886-1913 Ages Under 35... 35-44 45-64 65 and over. Total.. Under 35... 35-44 45-64 65 and over. Total.. MALES PERITONEUM, INTESTINES AND RECTUM No. of Deaths 32 62 155 25 Per Cent. 11.7 22.6 56.6 9.1 274 100.0 FEMALE GENERATIVE ORGANS FEMALES No. of Per Deaths Cent, 10 10.5 27 28.4 53 55.8 5 6.3 95 24 89 148 3 100.0 9.1 33.7 56.1 1.1 100.0 BREAST Under 35... 35-44 45-64 65 and over. Total. . Under 35... 35-44 45-64 65 and over. Total. . 3 100.0 3 100.0 SKIN 2 6.3 7 21.9 22 68.7 1 3.1 32 100.0 9 7.6 42 35.6 62 52.6 5 4.2 118 100.0 20.0 60.6 20.0 100.0 Under 35... 35-44 45-64 65 and over. Total.. OTHER OR NOT SPECIFIED ORGANS 61 15.1 83 20.5 218 53.8 43 10.6 405 100.0 13 12.6 36 35.0 51 49.5 3 2.9 103 100.0 ALL ORGANS AND PARTS Under 35 142 8.5 35-44 337 20.3 45-64 1,026 61.7 65 and over 158 9.5 Total 1,663 100.0 68 8.9 232 30.4 432 56.5 32 4.2 764 100.0 349 APPENDIX D Table 24 Ordinary Mortality Experience of The Prudential Insurance Company of America Mortality from Cancer, by Organs and Parts at Single Years of Life, Males 1886-1913 Age 19.. 20.. 21. . 22. . 23. . 24. . 25. . 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. Stomach Peritoneum Organs Buccal and Intestines Other not Ca\ aty Liver Rectum Breast Skin Organs Specified Total 1 4 2 4 i 4 5 3 4 4 4 i 2 3 3 1 5 3 2 2 7 1 4 3 9 1 2 1 2 7 1 2 3 3 11 4 4 6 14 2 5 4 4 16 9 1 5 16 5 5 7 18 9 2 6 17 1 10 3 5 20 2 11 11 8 32 16 7 8 32 2 17 6 11 37 1 16 2 6 26 3 18 13 1 8 43 16 6 1 7 31 7 16 1 3 8 38 2 21 6 1 6 38 5 21 7 3 40 3 33 7 1 1 5 51 3 24 11 2 11 52 4 27 16 18 66 1 26 7 2 18 54 4 36 6 11 58 2 28 13 1 . 14 59 3 38 4 10 56 2 34 6 2 13 59 43 10 2 14 72 3 30 7 1 8 50 3 26 9 2 6 46 5 30 •6 2 11 56 7 31 8 4 51 5 26 9 2 11 53 2 25 4 2 9 43 350 APPENDIX D Table 24 (concluded) Ordinary Mortality Experience of Tlie Prudential Insurance Company of America Mortality from Cancer, by Organs and Parts at Single Years of Life, Males 1886-191S Age Buccal Cav-ity Stomach Peritoneum and Intestines Liver Rectum Breast Skin Other Organs Organs not Specified Total 60 2 28 4 1 8 43 61 3 29 10 1 8 4 55 62 3 22 7 9 3 44 63 1 21 7 3 1 33 64 1 14 4 3 3 25 65 1 23 6 8 1 39 66 1 13 4 1 7 3 29 67 1 12 6 6 1 26 68 8 3 4 15 69 8 1 2 11 70 1 4 1 4 10 71 5 2 3 10 72 1 5 1 i 8 73 1 1 2 74 1 1 75 3 3 76 2 2 77 1 i 2 Total .... . . . . 89 860 274 3 32 354 51 1,663 351 APPENDIX D Table 25 Ordinary Mortality Experience of The Prudential Insurance Company of America Mortality from Cancer, by Organs and Parts at Single Years of Life, Females 1886-1913 Stomach Peritoneum Female Organs Buccal and Intest. Gener. Other not Age Cavity Li ver Rectum Organs Breast Skin Organs Specified Total 19 . 20 21 i 1 22 1 ! '.. 2 3 23 1 1 24 25 '. 2 2 26 27 1 1 28 2 "i 3 29 2 2 '. '.'. 2 6 30 1 1 3 3 8 31 1 1 3 1 .. 1 i 8 32 1 1 4 2 .. 1 9 33 3 4 4 1 12 34 2 3 4 2 3 14 35 2 1 8 1 3 1 16 36 3 2 5 3 .. 1 14 37 2 1 7 7 .. 1 '2 20 38 6 9 4 .. 3 22 39 4 7 5 1 3 i 21 40 2 1 13 5 .. 3 2 26 41 3 5 9 4 .. 2 23 42 4 3 16 7 .. 2 2 34 43 2 1 8 7.-3 1 22 44 10 6 9 3 .. 3 3 34 45 7 16 4 .. 1 2 30 46 6 2 15 7 .. 1 3 34 47 6 4 9 8 .. 7 1 35 48 7 4 12 7 5 1 36 49 7 2 6 3 1 1 20 50 2 7 7 5 .. 1 22 51 7 2 5 3 1 2 20 52 7 2 12 4 .. 3 28 53 7 7 10 6 .. 1 '2 33 54 9 1 3 2 .. 2 1 18 55 5 3 8 4 .. 1 1 22 56 4 2 9 4 1 20 57 10 3 5 1 2 21 58 9 3 8 1 .. 1 22 59 5 1 5 2 1 2 16 352 APPENDIX D Table 25 (concluded) Ordinary Mortality Experience of The Prudential Insurance Company of America Mortality from Cancer, by Organs and Parts at Single Years of Life, Females 1886-1913 Age Bu( Ca\ 'cal aty Stomach Peritoneum and Intest. Liver Rectum Female Gener. Organs Breast Skin Other Organs Organs not Specified Total 60 2 1 1 1 5 61.. 5 3 6 2 , , 1 17 62.. 4 1 8 2 15 63.. 2 1 2 1 , , "i i 8 64.. 4 4 1 1 10 65.. 1 3 1 i 6 66.. 5 , , 1 6 67.. 4 *i i 6 68.. 1 i i i 4 69.. 1 1 , , 2 70.. 2 . , "i 3 71.. . . . 1 i , , 2 72.. i , , i 2 73.. i .. 1 Total. 179 95 264 118 5 70 S3 764 353 APPENDIX D Table 26 Ordinary Mortality Experience of The Prudential Insurance Company of America Anthropometry in Mortality from Cancer, Males Weights and Age at Entry 1886-1912 DISTRIBUTION PER 10,000 DEATHS FROM CANCER —Ages at Entry- Weight 5 20 25 30 35 40 45 50 55 60 65 at to to to to to to to to to to and Entry ] 9 24 29 34 39 44 49 54 59 64 Over Total Under 110.. 7 7 110-119. .. 7 '7 14 21 '7 21 "7 "7 91 120-129. .. 14 57 21 50 57 29 29 29 286 130-139 . . 21 43 64 107 215 172 129 150 79 2i '7 1,008 140-149 . . 14 57 157 229 301 309 394 236 150 79 14 1,940 150-159. .. 57 143 186 215 323 215 352 215 72 7 1,785 160-169. . . 50 93 114 280 337 287 266 114 136 43 1,720 170-179 14 79 150 179 250 143 207 122 64 1,208 180-189 21 36 29 150 157 143 122 86 43 14 801 190-199 7 14 43 79 107 93 100 57 36 536 200-209 7 21 43 64 64 43 43 29 314 210-219 "7 14 14 29 64 14 36 178 220-229 7 14 14 14 7 7 63 230-239 7 7 14 7 14 '7 56 240-249 . . . 250-259 . . . 260 and over '7 "7 Total. . f )6 320 635 957 1,575 1,791 1,596 1,532 959 494 85 10,000 D ISTRIBUTION PER 10,000 DEATHS FROM ALL CAUSES Under 110.. .. ] 6 3 2 3 2 1 1 1 29 110-119 i J2 25 22 9 11 5 6 7 4 '2 i 124 120-129 , . rS 126 92 75 57 39 31 22 15 10 1 546 130-139 .. K )3 256 266 215 180 120 100 78 57 21 5 1,401 140-149 .. 1( )6 305 339 289 245 203 171 130 104 46 8 1,946 150-159 1 il 252 316 299 256 219 173 143 103 37 6 1,855 160-169 '.'. i >4 158 223 258 257 221 162 133 94 37 8' 1,575 170-179 6 71 137 160 160 135 115 94 75 24 6 983 180-189 4 33 82 81 107 106 93 76 70 21 6 679 190-199 14 30 57 68 62 58 48 36 15 3 391 200-209 5 15 31 29 41 34 25 21 9 2 212 210-219 2 6 19 23 19 27 21 13 6 1 137 220-229 1 4 7 10 16 15 13 5 2 73 230-239 2 5 6 5 5 3 5 2 33 240-249 2 2 2 1 2 1 1 11 250-259 i 2 1 4 260 and over "i 47 1 Total . . . . 4i JO 1,251 1,537 1,512 1,414 1,194 991 797 604 233 10,000 S54 APPENDIX D Table 27 Ordinary Mortality Experience of The Prudential Insurance Company of America Family History in Mortality, Cancer Compared with Tuberculosis, Males 1886-1912 DISTRIBUTION PER 10,000 DEATHS FROM CANCER \rrr of Insured at 50-59 Age of Father at His Death 20-i29 30-39 40-49 60-63 70-79 Total 20-29 10 39 29 39 10 10 137 30-39 19 58 155 155 107 19 513 40-49 58 136 214 408 291 29 1,136 50-59 29 204 495 505 320 21 1,574 60-69 39 262 932 1,097 544 87 2,961 70-79 10 165 553 1,039 689 87 2,543 80-89 49 214 427 301 19 1,010 90-99 10 58 39 19 291 126 Total 165 923 2,592 3,728 2,301 10,000 Age of Mother at Her Death 20-29 30-39 40-49 50-59 60-69 70-79 Total 20-29 68 113 34 11 226 30-39 ii 169 248 259 180 23 890 40-49 45 248 417 530 316 1,556 50-59 11 214 519 496 225 23 1,488 60-69 169 710 1,026 440 56 2,401 70-79 90 372 981 936 68 2,447 80-89 23 113 293 316 79 824 90-99 11 56 90 11 271 168 Total 67 913 2,458 3,754 2,537 10,000 DISTRIBUTION PER 10,000 DEATHS FROM TUBERCULOSIS OF THE LUNGS Age of Father at His Death 20-29 30-39 40-49 50-59 60-69 70-79 Total 20-29 66 69 21 17 . . .'. 173 30-39 345 324 204 72 17 . . 962 40-49 770 787 390 173 35 . . 2,155 50-59 614 1,022 639 207 52 3 2,537 60-69 293 808 680 352 97 17 2,247 70-79 93 352 452 345 76 14 1,332 80-89 17 86 173 173 55 7 511 90-99 17 35 21 10 . . 83 Total 2,198 3,465 2,594 1,360 342 41 10,000 Age of Mother at Her Death 20-29 30-39 40-49 50-59 60-69 70-79 Total 20-29 153 134 81 32 5 . . 405 30-39 599 604 396 167 27 9 1,802 40-49 676 887 450 189 59 5 2,266 50-59 387 910 568 234 50 13 2,162 60-69 90 604 725 410 85 5 1,919 70-79 18 126 432 423 153 23 1,175 80-89 14 54 108 54 . . 230 90-99 5 18 14 4 .. 41 Total 1,923 3,284 2,724 1,577 437 55 10,000 355 APPENDIX D Table 28 Mortality Experience of American Life Insurance Companies Medico-Actuarial Mortality Investigation, New York, 1913 Mortality from Cancer, according to Build, Males 1885-1908 Overweight 50 PouNoa AND More Standard Lives Underweight 25 Pounds and More Age at Entry Deaths from Cancer Rate per 10,000 Exposed to Risk Deaths from Cancer Rate per 10,000 Exposed to Risk Deaths from Cancer Rate per 10,000 Exposed to Risk 15-29 6 0.9 95 1.0 39 0.8 30-44...... 87 3.7 377 3.2 242 2.4 45 and over. 107 15.6 411 Cancer ' Per Cent, of All Causes 14.4 216 Cancer Per Cent, of All Causes 12.0 Cancer Per Cent, of All Causes 15-29 1.7 2.1 1.4 30-44 3.4 4.8 3.4 45 and over 6.0 7.7 7.3 Source: Medico-Actuarial Mortality Investigation, Vol. II, p. 34. New York, 1913. Table 29 Mortality Experience of American Life Insurance Companies Medico-Actuarial Mortality Investigation, New York, 1913 Mortality from Cancer and other Malignant Tumors, by Sex 1885-1908 MALES Policy Years 1 2 3-5 ... . 6-10. . . 11-24. . . Total. 1 2 3-5 ... 6-10. . . 11-24. . . Total. Number of Policies Terminated by Death . Ages at Entry 15-29 30-44 45-over 4 4 18 30 39 7 25 72 105 168 15 42 111 129 114 Percentage of All Deaths . Ages at Entry . 15-29 30-44 45-over 1.0 3.5 3.6 3.9 4.7 7.0 0.6 0.7 1.4 2.5 4.1 9.4 8.9 7.8 7.3 95 377 411 2.1 4.8 7.7 FEMALES Rate per 10,000 Exposed to Risk . Ages at Entry . 15-29 30-44 45-over 0.2 0.4 3.2 0.3 1.9 12.0 0.7 2.3 13.6 1.2 3.3 16.4 2.3 7.6 26.3 7 50 55 1.1 6.4 13.6 5 52 64 0.9 6.9 15.8 24 199 196 1.9 11.0 15.2 26 240 212 3.0 15.6 13.1 36 127 127 11.5 16.3 10.5 98 668 654 2.7 11.8 13.3 1.0 0.5 0.5 1.0 1.6 7.2 1.4 3.2 14.4 3.0 12.1 4.0 18.1 6.6 23.5 10.3 28.8 15.4 40.7 7.3 24.3 Source: Medico- Actuarial Mortality Investigation, Vol. II, p. 31, et seq. New York, 1913 356 APPENDIX D Table 30 Mortality Experience of Twenty-seven American Insurance Companies (Meech) from Organization to 1873 Mortality from Cancer, with Distinction of Age and Sex MALES AND FEMALES Ages 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80 and over Total 37,624 IVMLES 10-19 133 20-29 30-39 40-49 50-59 60-69 70-79 80 and over Total 35,442 FEMALES 10-19 18 20-29 360 30-39 698 40-49 563 50-59 317 60-69 164 70-79 51 80 and over 11 Total 2,182 Deaths Deaths from All from Cancer Causes Cancer Per Cent. 151 , , 3,836 9 0.2 10,019 77 0.8 11,403 210 1.8 7,893 255 3.2 3,521 111 3.2 698 22 3.2 103 •• 684 632 1.8 3,476 8 0.2 9,321 72 0.8 10,840 186 1.7 7,576 239 3.2 3,357 107 3.2 647 20 3.1 92 •• 1.8 1 0.3 5 0.7 24 4.3 16 6.0 4 2.4 2 3.9 52 2.4 357 APPENDIX D Table 31 Mortality Experience of The Aetna Life Insurance Company Mortality from Cancer 1870-1913 Year 1870 1871 1872 1873 1874 1875 1876 1877 1878 1879 1880 1881 1882 1883 1884 1885 1886 1887 1888 1889 1890 1891 1892 1893 1894 1895 1896 1897 1898 1899 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1870-1890. 1891-1913. Deaths Deaths from All from Cancer Causes Cancer Per Cent. 426 11 2.6 432 7 1.6 486 8 4.6 579 18 3.1 474 10 2.1 527 16 3.0 536 14 2.6 544 15 2.8 502 20 4.0 532 23 4.3 542 23 4.2 503 20 3.4 565 23 4.1 656 37 53 645 27 4.2 667 30 4.5 715 36 5.0 719 34 4.9 783 23 2.9 761 37 4.9 817 34 4.2 897 45 5.0 1,019 51 5.0 1,013 48 4.7 956 53 5.5 1,052 40 3.8 1,029 40 3.9 1,044 65 5.3 1,051 48 4.6 1,114 54 4.8 1,215 83 6.8 1,303 84 6.4 1,267 55 4.3 1,386 87 6.3 1,432 70 4.9 1,388 97 7.0 1,514 111 7.3 1,536 104 6.8 1,504 117 7.8 1,605 112 7.0 1,783 122 6.8 1,702 127 7.5 1,628 123 7.6 1,658 117 7.1 12,411 466 3.8 30,096 1,843 6.1 358 APPENDIX D Table 32 Mortality Experience of The Mutual Life Insurance Company of New York Mortality from Cancer, by Age and Sex 1843-1914 MALES Ages Undergo. 20-24.... 25-29.... 30-34. . . . 35-39. . . . 40-44 45-49. . . . 50-54.... 55-59.... 60-64.... 65-69. . . . 70-74.... 75-79.... 80-84.... 85 and over. Deaths Deaths from All from Cancer Causes Cancer Per Cent 252 3 1.19 1,874 15 0.80 4,693 48 1.02 7,258 106 1.46 10,058 269 2.67 11,750 469 3.99 13,103 690 5.27 14,001 1,005 7.18 14,300 1,112 7.78 13,668 1,086 7.95 12,625 875 6.93 10,152 628 6.19 7,382 386 5.23 4,071 130 3.19 1,870 52 2.78 FEMALES Deaths from All Causes Deaths from Cancer Cancer Per Cent 18 151 2 1.32 413 4 0.97 647 18 2.78 720 56 7.78 802 104 12.97 764 136 17.80 730 136 18.63 725 138 19.03 701 97 13.84 612 71 11.60 448 46 10.27 339 15 4.42 163 7 4.29 69 •• 830 11.37 Total 127,079* 6,874 5.41 7,303t Source: Report on the Mortality Records of The Mutual Life Insurance Company of New York from 1843 to 1898. New York, 1900. 1899-1914, courtesy of Brandreth Symonds, Chief Medical Director of The Mutual Life Insurance Company of New York. •Including 22 age not stated. tincluding 1 age not stated. Table 33 Mortality Experience of The Mutual Life Insurance Company of New York Mortality from Cancer, by Age and Sex 1843-1914 MALES All Ages Deaths Deaths Cancer from All from Per Causes Cancer Cenf. 1843-1873 5,223* 94 1.80 1874-1885 10,839 449 4.14 1886-1893 14,568 631 4.33 1894-1898 14,355 708 4.93 1899-1914 82,094 4,992 6.09 1843-1914 127,079* 6,874 5.41 35,885 910 2.54 Under 45 Deaths from All Causes 2,674 3,028 3,658 4,263 22,262 Deaths Cancer from Per Cancer Cent. 25 0.93 71 65 95 654 2.34 1.78 2.23 2.94 FEMALES 162t 247 456 675 1899-1914 5,763 1843-1873. 1874-1885. 1886-1893. 1894-1898. 8 4.94 24 9.72 45 9.87 50 7.41 703 12.23 76 5 6.58 85 3 74 4 5.41 173 20 147 10 6.80 309 35 265 6 2.26 410 44 2,189 159 7.26 3,574 544 Deaths from All Causes 2,527 7,811 10,910 10,092 59,832 Deaths from Cancer 45 AND Over Cancer Per Cent. 69 2.72 378 4.84 566 613 4,338 5.19 6.07 7.25 91,172 5,964 6.54 3.53 11.56 11.33 10.73 15.22 1843-1914 7,303t 830 11.37 2,751 184 6.69 4,551 646 14.19 Source: Report on the Mortality Records of The Mutual Life Insurance Company of New York from 1843 to 1898. New York, 1900. 1899-1914, courtesy of Brandreth Symonds, Chief Medical Director of The Mutual Life Insurance Company of New York. *Including 22 age not given. flncluding 1 age not stated. 359 APPENDIX D Table 34 Mortality Experience of The Mutual Life Insurance Company of New York Mortality from Other Tumors, by Age and Sex 1843-1898 . MALES FEMALES Deaths Deaths f-' Deaths Deaths from All from Tumor from AH from Tumor Ages Causes Tumor Per Cent. Causes Tumor Per Cent. Under 20 38 •• 2 30 20-24 569 25-29 1,775 4 0.23 78 30-34 2,900 5 0.17 136 1 0.73 35-39 4,034 18 0.45 141 40-44 4,307 12 0.28 175 2 1.14 45-49 4,621 17 0.37 156 50-54 4,944 13 0.26 159 55-59 5,283 9 0.17 185 60-64 5,016 12 0.24 160 2 1.25 65-69 4,593 16 0.35 122 2 1.64 70-74 3,406 10 0.29 71 1 1.41 75-79 2,212 1 0.05 92 80-84 956 1 0.10 25 85 and over 309 2 120 0.65 0.27 7 8 Total 44,985* l,540t 0.52 Source: Report on the Mortality Records of The Mutual Life Insurance Company of New York from 1843 to 1898. New York, 1900. •Including 22 age not stated. tlncluding 1 age not stated. Table 35 Mortality Experience of The New York Life Insurance Company Mortality from Cancer and Other Tumors 1901-1913 Deaths Deaths from from All Cancer and Per Year Causes Other Tumors Cent. 1901 4,593 206 4.5 1902 5,094 253 5.0 1903 5,573 289 5.2 1904 6,632 339 5.1 1905 7,701 370 4.8 1906 7,244 384 5.3 1907 7,593 401 5.3 1908 7,568 480 6.3 1909 7,719 575 7.4 1910 8,039 588 7.3 1911 8,314 606 7.3 1912 8,549 631 7.4 1913 8,793 660 7.5 Furnished by Mr. Arthur Hunter, Actu- ary of The New York Life Insurance Company. 360 APPENDIX D Table 36 Mortality Experience of The Northwestern Mutual Life Insurance Company Mortality from Cancer, by Age, Males 1857-1909 1857-1885 1886-1909 Deaths Deaths Deaths Deaths from All from Cancer from All from Cancer Ages Causes Cancer Per Cent. Causes Cancer Per Cent. Under 20 22 32 2,195 24 20-29 388 1.1 30-39 1,099 18 1.6 4,832 107 2.2 40-49 1,541 59 3.8 6,327 335 5.3 50-59 1,381 63 4.6 6,624 525 7.9 60-69 792 39 4.9 5,982 529 8.8 70-79 141 6 4.3 3,897 248 6.4 80 and over 3 185 3.4 1.172 32 2.7 Total 5,367 31,061 1,800 5.8 Table 37 Mortality Experience of The Washington Life Insurance Company Mortality from Cancer, by Age 1860- 1S86 Ages 19-29 30-39 40-49 50-59 60-69 70-81 Total Source: The Washington Life Insurance Medical Statistics. New York, 1889. Note — During this same period there were seven deaths from tumors, the deaths from this cause representing 0.35% of the total mortality. Deaths from All Causes Deaths from Cancer Cancer Per Cent 139 1 0.7 413 5 1.2 593 15 2.5 451 24 5.3 303 18 5.9 101 5 68 4.9 2,000 3.4 ipany: Historical, Actuarial anc Table 38 Mortality from Cancer in Foreign Life Insurance Companies Deaths Number of from All Companies Causes 16 German companies 137,609 1 Swiss company 1,253 1 Japanese company 7,473 13 Austrian companies 85,334 1 Dutch East Indian company 161 1 Hungarian company. 3,117 1 British Indian company 1,435 Source: Annual Reports of the several companies. from Cancer Cancer Per Cent 15,191 11.0 129 10.3 709 9.5 8,052 9.4 15 9.3 253 8.1 22 1.5 361 APPENDIX D Table 39 Mortality from Cancer in the Experience of Thirty-four Insurance Companies Deaths Deaths Cancer No Period Companies from All from Per Causes Cancer Cent. 1. 1903—1912 GothaerLebensversicherungsbank, Gotha, Ger- many 20,030 2,518 12.6 2. 1907-1912 Deutsche Lebensversicherung, Potsdam, Ger- many 4,092 510 12.5 3. 1893-1913 Leipziger Lebensversicherungs - Gesellschaft, Leipzig, Germany 22,456 2,770 12.3 4. 1905-1912 Teutonia Versicherungs - Actien - Gesellschaft, Leipzig, Germany '. 9,780 1,166 11.9 5. 1906-1913 Deutsche Lebensversicherungs - Gesellschaft, Lubeck, Germany 6,729 791 11.8 6. 1901-1906 Stuttgarter Lebensversicherungsbank, Stutt- gart, Germany 6,953 817 11.8 7. 1907-1913 "Concordia" Mutual Life Insurance Company, Reichenberg, Austria 1,018 118 11.6 8. 1900-1912 Erster Allgemeiner Beamten-Verein der Oster- reichisch-Ungarischen Monarchic, Vienna, Austria 17,507 2,000 11.4 9. 1896-1913 Friedrich Wilhelm, Berlin, Germany 10,332 1,113 10.8 10. 1900-1905 Karlsruher Lebensversicherung, Karlsruhe, Germany 6,790 723 10.6 11. 1908-1912 "Donau," Vienna, Austria 2,164 227 10.5 12. 1901-1913 "La Suisse" Societe d' Assurances sur la vie et con tre les accidents, Lausanne, Switzerland . . 1,253 129 10.3 13. 1901-1913 Magdeburger Lebensversicherungs - Gesell- schaft, Magdeburg, Germany 10,215 1,039 10.2 14 1907-1912 "Janus" Mutual Life Insurance Company, Vienna, Austria .8,678 370 10.1 15. 1896-1913 Lebens - und Pensions - Versicherungs - Gesell- schaft "Janus," Hamburg, Germany 9,172 921 10.0 16. 1907—1913 "Freia" Bremen-Hannoversche Lebensversich- erungs-Bank, Hanover, Germany 3,981 387 9.7 17. 1900-1907 "Praha" Mutual Life Insurance Company, Prague, Austria 1,424 138 9.7 18. 1908-1911 Lebensversicherungs-Anstalt und Sterbekasse des Deutschen Kriegerbundes, Berlin, Ger- many 6,513 625 9.6 19. 1903—1906 Sachsischer Militar Lebensversicherungs- Verein, Dresden, Germany 2,419 230 9.5 20. 1901-1912 Osterreichischer Phoenix, Life Insurance Com- pany, Vienna, Austria 10,624 1,008 9.5 21. 1899-1912 Assicurazioni Generali, Trieste, Austria 15,622 1,461 9.4 22. 1911-1913 Nederlandsch - Indische Lebensverzekeringen Lijf rente Maatschappij, Batavia, Dutch East Indies 161 15 9.3 23. 1905-1912 Mutual Insurance Company, Krakau, Austria 4,174 385 9.2 24. 1907-1912 "Universale" Industrial Insurance Company, Vienna, Austria 8,594 790 9.2 362 APPEXDIX D Table 39 (concluded) Mortality from Cancer in the Experience of Thirty-four Insurance Companies Deaths Deaths Cancer No. Period Companies from All from Per Causes Cancer Cent. 25. 1903-191.3 "Victoria" zii Berlin, Insurance Company, Berlin, Germany ." . 15,733 1,385 8.8 2G. 1904-1912 Niederosterreichische Landes - Lebens und Renten-Versicherimgs-Anstalt, Vienna, Aus- tria 1,451 126 8.7 27. 1899-1912 Riunione Adriatica di Sicurta, Trieste, Austria . 9,454 811 8.6 28. 1906—1913 "Deutschland" Life Insurance Company, Berlin, Germany 2,010 168 8.4 29. 1900-1912 "Fonciere" Pester Versichenings-Anstalt, Bu- dapest, Hungary 3,117 253 8.1 30. 1906-1912 Landes-Lebensversicherungs-Anstalt der Mark- grafschaft Maehren, Bruenn, Austria •. 1,466 104 7.1 31. 1904—1913 "Atlas" Life Insurance Company, Ludwigs- hafen, Germany 404 28 6.9 32. 1901-1913 Lebens-und Rentenversicherungs-Gesellschaft "Der Anker," Vienna, Austria 8,158 514 6.3 33. 1911-1912 Oriental Government Security Life Assurance Company, Ltd., Bombay, British India 1,435 22 1.5 34. 1899-1907 Meiji Life Assurance Company, Tokio, Japan . . 7,473 709 9.5 Source: Annual Reports of the several companies. Table 40 Mortality Experience of The British Empire Mutual Life Assurance Company Mortality from Cancer and Tumor, by Age 1847-1872 Cancer Tdmor Deaths Deaths Deaths Tumor from Ail from Cancer from Per Ages Causes Cancer Per Cent. Tumor Cent. Under 20 5 20-24 34 25-29 100 1 1.0 30-34 170 1 0.6 35-39 247 2 0.8 40-44 272 8 2.9 3 1.1 45-49 280 9 3.2 2 0.7 50-54 271 9 3.3 3 1.1 55-59 230 11 4.8 2 0.9 60-64 153 1 0.7 1 0.7 65-€9 112 3 2.7 70-74 73 1 1.4 75-79 35 80 and over 17 43 2.2 Total 1,999 14 0.7 Source: Tables of the Mortality Experience of The British Empire Mutual Life Assurance Company from 1847 to 1884. 363 APPENDIX D Table 41 Mortality Experience of Tlie Britisli Empire Mutual Life Assurance Company Mortality from Cancer and Tumor, by Age 1873-1878 Cancer TUMOH Ages Deaths from All Causes Deaths from Cancer Cancer Per Cent. Deaths from Tumor Tumor Per Cent. Under 25 3 25-29 24 30-34 49 i 2.6 35-39 80 1 1.3 i 1.3 40-44 87 2 2.3 45-49 109 2 1.8 i 0.9 60-54 154 4 2.6 1 0.6 65-59 185 9 4.9 1 0.5 60-64 183 6 3.3 1 0.5 65-69 147 6 4.1 70-74 94 3 3.2 75-79 38 1 2.6 i 2.6 80 and over 26 1 36 3.8 3.1 6 Total 1,179 0.5 Mortality Experience, Publicans Only, 1846-1876 1846-1876 123 2 1.6 | 1 Mortality Experience, 1879-1884 1879-1884 1,300 42 3.2 | 10 0.8 0.8 Source: Tables of the Mortality Experience of The British Empire Mutual Life As- surance Company from 1847 to 1884. Table 42 Mortality Experience of The Clergy Mutual Assurance Society Mortality from Cancer, by Age, 1829-1887 Deaths Deaths from All from Cancer Ages Causes Cancer Per Cent. Under 20 1 20-29 45 30-39 164 4 2.4 40-49 272 17 6.3 60-59 478 25 5.2 60-69 562 33 5.9 70-79 444 21 4.7 80-89 147 2 1.4 90 and over 6 Total 2,119 102 4.8 Source : Report on the Mortality Experience of The Clergy Mutual Assurance Society, from 1829 to 1887. London, 1891. Note: During this same period there were six deaths from tumor in the experience of The Clergy Mutual Assurance Society, 2, or 0.7, at ages 40-49; 1, or 0.2, at ages 50-59; 1, or 0.2, at ages 60-69; and 2, or 0.5, at ages 70-79. 364 APPENDIX D Table 43 Mortality Experience of The Clergy Mutual Assurance Society Mortality of Persons Assured as "Unhealthy Lives," 1829-1887 Ages Under 20. . . 20-29 30-39 40-49 50-59 60-«9 70-79 80-89 90 and over. Total. . . . Deaths Deaths from All from Cancer Causes Cancer Per Cent i 4 11 30 2 6.7 14 10 1 71 Source: Report on the Mortality Experience of The Clergy Mutual Assurance Society from 1829 to 1887. London, 1891. Table 44 Mortality Experience of The Equitable Society, London, Eng. Cancer Mortality, 1801-1832 Deaths Deaths from All from Cancer Ages Causes Cancer Per Cent. 10-19 12 20-29 67 30-39 266 2 0.8 40-49 544 5 0.9 50-59 883 14 1.6 60-69 1,173 15 1.3 70-79 856 4 0.5 80 and over. . 294 3 43 1.0 Total 4,095 1.1 Source: Tables showing the total num- ber of persons assured in The Equitable Society from its commencement in Septem- ber, 1762, to January 1, 1829, and a supple- ment showing the mortality of the Society for the years 1829 to 1832. London, 1834. 365 APPENDIX D Table 45 Mortality Experience of The Gresham Life Assurance Society Mortality from Cancer and Tumor, by Age Up to July 15, 1866 Ages Under 20 Deaths from All Causes 10 Cancer Deaths from Cancer i 3 .6 7 3 1 21 Cancer Per Cent. 1.4 1.1 2.3 3.1 2.8 1.9 2.1 Deaths from All Causes 10 73 268 263 225 107 54 TuMOK Deaths from Tumor i 1 1 1 4 Tumor Per Cent. 20-29 30-39 40-49 50-59 73 268 263 225 0.4 0.4 0.4 60-69 107 0.9 70-79 54 Total 1,000 1,000 0.4 Source: Gresham Life Assurance Society, Tl?e Causes of Death, tabulated by A. H. Smee, 1868. Table 46 Mortality Experience of The Metropolitan Life Assurance Society, England Mortality from Cancer and Tumor, by Age 1835-1864 Cancer Tumor Deaths Deaths Deaths from All from Cancer from Tumor Ages Causes Cancer Per Cent, Tumor Per Cent. Under 20 2 •• i 20-29 22 4.5 30-39 77 i 1.3 40-49 147 2 1.4 50-59 176 3 1.7 i 0.6 60-69 173 5 2.9 70-79 60 5 8.3 80 and over 14 Total 671 16 2.4 2 0.3 Source: Metropolitan Life Assurance Society, Mortality Experience from 1835 to 1864. 366 APPENDIX D Table 47 Mortality Experience of The Prudential Assurance Company, London, Eng. Mortality from Cancer, by Age and Sex 1867-1870 MALES FEMALES Deaths Deaths Deaths Deaths from All from Cancer from All from Cancer Ages Causes Cancer Per Cent. Causes Cancer Per Cent. Under 5 7,568 6 0.08 6,941 8 0.12 &-9 1,405 2 0.14 1,327 1 0.08 10-14 687 1 0.15 620 15-S24 1,392 2 0.14 1,445 4 0.28 25-34 760 6 0.79 981 6 0.61 35-54 2,290 39 1.70 2,312 166 7.18 55 and over 3,297 82 138 2.49 0.79 4,147 167 352 4.03 Total 17,399 17,773 1.98 Source: Mortality Experience of The Prudential Assurance Company in the Indus- trial Branch for the years 1867 to 1870. London, 1871. Table 48 Mortality Experience of The Prudential Assurance Company, London, Eng. Mortality from Tumor, by Age and Sex 1867-1870 IMALES FE^Ly^ES Deaths Deaths Deaths Deaths f 'om All from Tumor from All from Tumor Ages Causes Tumor Per Cent. Causes Tumor Per Cent. UnderS 7,568 , , 6,941 1 0.01 5-9 1,405 1,327 4 0.30 10-14 687 i 0.14 620 15-24 1,392 1 0.07 1,445 2 0.14 25-34 760 1 0.13 981 1 0.10 35-54 2,290 5 0.22 2,312 21 0.91 55 and over 3,297 8 16 0.24 0.09 4,147 18 47 0.43 Total 17,399 17,773 0.26 Source: Mortality Experience of The Prudential Assurance Company in the Indus- trial B ranch for the years 1867 to 1870. London, 1871 . 367 APPENDIX D Table 49 Mortality Experience of The Prudential Assurance Company, London, Eng. Mortality from Cancer, by Organs and Parts, according to Age 1867-1870 MALES Organ or Part Head, face, mouth, tongue, eyes and ears . Breast Stomach Liver Rectum Not defined All organs 138 Head, face, mouth, tongue, eyes and ears . Breast Stomach Liver Rectum Not defined All organs . Head, face, mouth, tongue, eyes and ears . Breast Stomach Liver Rectum Not defined All Ages Undeh is Deaths from Cancer Per Cent. Deaths from Cancer Per Cent 30 21.7 4 44.4 1 0.7 30 21.7 , , 24 17.4 8 5.8 45 32.6 5 55.Q 138 100.0 9 100.0 15-24 25- -34 1 16.7 i 16.7 2 33.3 k 100.6 '2 33.3 2 100.0 6 100.0 35-54 55 AND Over 7 17.9 18 22.0 1 1.2 6 15.4 23 28.0 10 25.6 12 14.6 3 7.7 5 6.1 13 33.3 23 28.0 39 100.0 82 100.0 All organs Source: Mortality Experience of The Prudential Assurance Company in the Indus- rial Branch for the years 1867 to 1870. London, 1871. APPENDIX D Table 50 Mortality Experience of The Prudential Assurance Company, London, Eng. Mortality from Cancer, by Organs and Parts, according to Age 1867-1870 FEMALES All Ages Organ or Part Deaths from Cancer Head, face, mouth, tongue, eyes and ears 24 Breast 55 Stomach 39 Liver 25 Rectum 5 Kidneys and bladder 2 Uterus 127 Heart 1 Leg 1 Notdefined 73 All organs 352 Head, face, mouth, tongue, eyes and ears . Breast Stomach Liver Rectum Kidneys and bladder Uterus Heart Leg Not defined All organs . Head, face, mouth, tongue, eyes and ears . Breast Stomach Liver Rectum Kidneys and bladder Uterus Heart Leg Not defined 20 9 11 3 1 84 32 Per Cent. 6.8 15.6 11.1 7.1 1.4 0.6 36.1 0.3 0.3 20.7 100.0 15-24 1 25.0 50.0 25.0 100.0 3.6 12.0 5.4 6.6 1.8 0.6 50.6 19.3 100.0 Undeb 15 Deaths from Cancer Per Cent. 1 11.1 9 100.0 25-34 2 33.3 1 16.7 1 16.7 2 33.3 6 100.0 55 AND OVEB 9 33 27 13 2 1 41 1 1 39 167 5.4 19.8 16.2 7.8 1.2 0.6 24.5 0.6 0.6 23.3 100.0 All Organs 166 Source: Mortality Experience of The Prudential Assurance Company in the Indus- trial Branch for the years 1867 to 1870. London, 1871. 369 APPENDIX D Table 51 Mortality Experience of The Scottish Amicable Life Assurance Society Mortality from Cancer, by Age 1826-1860 Deaths Rate per Lives at from 100,000 Ages Eisk Cancer Lives Under 25 . . . . 2,349 25-34 . 14,665 35-44 . 19,330 O 25.9 45-54 . 12,401 7 56.4 55-64 . 5,682 1 17.6 65 and over.. . 1,873 1 14 53.4 Total .... . 56,300 24.9 Source: Medical Statistics of Life As- surance: Being an inquiry into the causes of death among the members of The Scot- tish Amicable Life Assurance Society from 1826 till 1860. Glasgow, 1862. Table 52 Mortality Experience of The Scottish Amicable Life Assurance Society Mortality' from Cancer, by Age and Sex, Non-hazardous Occupations 1826-1860 MALES FEMALES Ages Deaths from AU Causes Deaths from Cancer Cancer Per Cent. Deaths from All Causes Deaths from Cancer Cancer Per Cent. Under 25 15 1 9 25-34 90 35-44 170 4 2.4 19 1 5.3 45—54 147 3.4 8 2 25.0 55-64 114 0.9 10 65-74 79 1.3 13 3 75 and over 17 Total 632 11 1.7 63 3 5.3 Source: Medical Statistics of Life Assurance: Being an inquiry into the causes of death among the members of The Scottish Amicable Life Assurance Society from 1826 till 1860. Glasgow, 1862. 370 APPENDIX D Table 53 Mortality Experience of The Scottish Amicable Life Assurance Society Mortality from Tumor, by Age and Sex, Non-Hazardous Occupations 1826-1860 MALES FEMALES Agea No. of Deaths Per Cent. No. of Per Deaths Cent, Under 25 0.7 0.9 55-34 35-44 45-54 55-64 65-74 75 and over ........ i 1 Total 2 0.3 Source: Medical Statistics of Life Assurance: Being an inquiry into the causes of death among the members of The Scottish Amicable Life Assurance Society from 1826 till 1860. Glasgow, 1862. Table 54 Mortality Experience of The Scottish Amicable Life Assurance Society Mortality from Cancer, by Age, Hazardous Occupations 1826-1860 Ages Under 25.. . 25-34 35-44 45-54 55-64 65-74 75 and over Total. . Exclusive op West Indies Deaths from All Causes 1 7 10 11 10 47 Deaths from Cancer Cancer Per Cent. West Indies Deaths Deaths from All from Cancer Causes Cancer Per Cent. 6 9 12 4 31 Source: Medical Statistics of Life Assurance: Being an inquiry into the causes of death among the members of The Scottish Amicable Life Assurance Society from 1826 till 1860. Glasgow, 1862. 371 APPENDIX D Table 55 Mortality Experience of The Scottish Union and National Insurance Com- pany, 1912 Mortality from Cancer, by Organs and Parts Deaths from Cancer Organ or Part Cancer Per Cent. Mouth and throat 1 0.2 Larynx 1 0.2 Lung 5 1.1 Mediastinum 5 1.1 Stomach 4 0.9 Pancreas 1 0.2 Liver 1 0.2 Intestines 16 3.5 Peritoneum 1 0.2 Bladder 2 0.4 Prostate Gland 3 0.7 Vesicula seminalis 1 0.2 Uterus 1 0.2 Bone 1 0.2 Not stated 1 0.2 All organs 44 9.5 Source: Analysis of Deaths in The Scottish Union and National Insurance Company, 1912. Note: All the above deaths are males except the one death from cancer of uterus. Table 56 Mortality Experience of The Scottish Widows' Fund and Life Assurance Society Mortality from Cancer and Tumor, by Age 1815-1845 Cancer TUMOB Deaths Deaths Deaths from All from Cancer from Tumor Ages Causes Cancer Per Cent. Tumor Per Cent. 20-30 28 30-40 109 2 1.8 40-50 143 2 1.4 50-60 143 2 1.4 2 1.4 60-70 123 2 1.6 70-80 57 1 1.8 AboveSO 12 Unknown 27 Total 642 6 0.9 5 0.8 Source: Observations on the Mortality of The Scottish Widows' Fund and Life Assurance Society from 1815 to 1845. Edinburgh, 1847. 372 APPENDIX D Table 57 Mortality Experience of The Scottish Widows' Fund and Life Assurance Society Mortality from Cancer and Tumor, by Age 1846-1852 Cancer Tumor Deaths Deaths Deaths from All from Cancer from Tumor Ages Causes Cancer Per Cent. Tumor Per Cent. 20-30 24 1 4.2 30-40 83 40-50 144 i 0.7 50-60 178 2 i.i 2 1.1 60-70 151 2 1.3 2 1.3 70-80 82 2 2.4 Above 80 28 Total 690 5 0.7 7 1.0 Source: Medical Statistics of Life Assurance, Observations on the Causes of Death among the Assured of The Scottish Widows' Fund and Life Assurance Society from 1846 to 1852. Edinburgh, 1853. Table 58 Mortality Experience of The Scottish Widovi's' Fund and Life Assurance Society Mortality from Cancer and Tumor, by Age 1853-1859 Cancer Tumor Deaths Deaths Deaths from All from Cancer from Tumor Ages Causes Cancer Per Cent. Tumor Per Cent. 20-30. 33 , , 30-40. 106 i 0.9 , , 40-50. 167 4 2.4 50-60. 245 5 2.0 2 0.8 60-70. 242 15 6.2 1 0.4 70-80. 150 2 1.3 Above 80 32 1 3.1 Total 975 28 2.9 3 0.3 Source: On the Causes of Death in The Scottish Widows' Fund and Life Assurance Society, 1853-1859. Edinburgh, 1860. 373 APPENDIX D Table 59 Mortality Experience of The Scottish Widows' Fund and Life Assurance Society Proportionate Mortality from Cancer, by Age 1874-1880 Compared with 1888-1894 Ages 25-35 35-45 45—55 55-65 1874-1880 Cancer Per Cent. 1.64 8.20 12.30 33.60 36.88 1888-1894 Cancer Per Cent 2.78 8.73 21.83 31.75 25.79 9.12 100.00 Variations + 1.14 +0.53 +9.53 -1.85 -11.09 75 and over 7.38 -1.74 Total 100.00 Source: The Causes of Death among the Assured in The Scottish Widows' Fund and Life Assurance Society from 1874 to 1894, inclusive. Edinburgh, 1902. Table 60 Mortality Experience of The Scottish Widows' Fund and Life Assurance Society Annual Mortality from Cancer among 100,000 Males Living at Each "Group of Ages," 1874-1894 Ages 1874-1880 Rate Per 100,000 Lives 1881-1887 Rate Per 100,000 Lives 1888-1894 Rate Per 100,000 Lives 25-34 35-44 45-54 55-64 65-74 5.1 21.9 47.2 207.8 469.8 4.2 23.7 73.4 258.9 336.7 422.2 14.9 29.5 90.2 245.3 451.8 75 and over 346.8 483.3 Total 78.6 81.9 104.2 Source: The Causes of Death among the Assured in The Scottish Widows' Fund and Life Assurance Society from 1874 to 1894, inclusive. Edinburgh, 1902. 374 APPENDIX D Table 61 Mortality Experience of The Scottish Widows' Fund and Life Assurance Society Mortality from Cancer of Internal and External Organs, Males 1874-1894 Intern AL CbGANS 1874-1880 1881-1887 1888-1894 1874-1894 Organ or Part No. % No. % No. % No. % Stomach 28 24.56 33 21.85 50 20.24 Ill 21.68 Liver 23 20.18 28 18.55 42 17.00 93 18.17 Bowel 5 4.39 15 9.93 23 9.31 43 8.40 Abdomen 7 6.14 13 8.60 14 5.67 34 6.64 Bladder 5 4.39 3 1.99 8 3.24 16 3.13 Mediastinum 1 0.88 8 5.30 4 1.62 13 2.54 Qilsophagus 2 1.75 2 1.33 8 3.24 12 2.34 Prostate 3 2.63 2 1.33 3 1.21 8 1.56 Kidneys 2 1.75 1 0.66 4 1.62 7 1.37 Pancreas 3 2.63 3 1.21 6 1.17 Lung 2 1.75 i 0.66 2 0.81 5 0.98 Brain 1 0.41 1 0.19 Spinal cord 1 0.66 1 0.19 All organs 81 71.05 EXTEB> 107 70.86 rAL Organs 162 65.58 350 68.36 Rectum 12 10.52 26 17.22 30 12.14 68 13.28 Tongue 8 7.02 2 1.33 13 5.26 23 4.49 Tissues 4 3.51 5 3.31 8 3.24 17 3.32 Throat 3 2.63 1 0.66 5 2.02 9 1.76 Larynx 1 0.88 1 0.66 6 2.43 8 1.56 Bones 1 0.66 6 2.43 7 1.37 Mouth 1 0.88 2 1.33 2 0.81 5 0.96 Parotid 3 2.63 1 0.66 1 0.41 5 0.98 Glands.... 1 0.66 4 1.62 5 0.98 Penis 1 0.88 2 1.33 1 0.41 4 0.78 Jaw 4 1.62 4 0.78 Testes 2 0.81 2 0.39 Eye 1 0.66 1 0.41 2 0.39 Lip 2 0.81 2 0.39 Skin i 0.66 1 0.19 All organs 33 28.95 44 29.14 85 34.42 162 31.64 Source: The Causes of Death among the Assured in The Scottish Widows' Fund and Life Assurance Society from 1874 to 1894, inclusive. Edinburgh, 1902. 375 APPENDIX D Table 62 Mortality Experience of The Scottish Widows' Fund and Life Assurance Society Annual Mortality from Cancer of Internal and External* Organs among 100,000 Males Living at All Ages, 1874-1894 External Organs Rate per 100,000 Lives Ratio 21.2 100.0 21.8 102.8 35.2 166.0 Internal Organs Rate per Period 100,000 Ratio Lives 1874-1880 52.2 100.0 1881-1887 53.1 101.7 1888-1894 67.0 128.4 Source: The Causes of Death among the Assured in The Scottish Widows' Fund and Life Assurance Society from 1874 to 1894, inclusive. Edinburgh, 1902. *Rectum is included in external organs. Table 63 Mortality Experience of British and German Life Insurance Companies Proportionate Mortality from Cancer Up to 1860 Cancer Per Cent. Gotha Life Insurance 2.83 Scottish Amicable 1.81 Scottish Widows' Fund 1.69 Standard 2.07 North British 1.91 London Equitable 1.05 England and Wales, 1848-1854 2.61 Source: Aus der Praxis der Gothaer Lebensversicherungs-Bank. Jena, 1902. Table 64 Mortality Experience of German Life Insurance Companies Mortality from Cancer, 1899-1912 Deaths Deaths Number of from All Year Companies Causes 1899 4 5,530 1900 '. 5 6,607 1901 7 8,532 1902 7 8,543 1903 6 5,627 1904 8 6,393 1905 9 7,844 1906 10 7,587 1907 11 7,765 1908 11 8,368 1909 11 8,473 1910 12 10,378 1911 12 10,892 1912 11 9.439 1899-1912 111,978 12,190 10.9 Source: Annual Reports of the several companies. 376 from Cancer Cancer Per Cent 645 11.7 735 11.1 933 10.9 1,006 11.8 608 10.8 696 10.9 837 10.7 883 11.6 865 11.1 815 9.7 897 10.6 1,106 10.7 1,165 10.7 999 10.6 APPENDIX D Table 65 Mortality Experience of the Life Insurance Company of the "Deutscher Kriegerbund" ( German Veteran Society), Berlin, Germany Mortality from Cancer 1908-1911 Deaths Deaths from All from Cancer Year Causes Cancer Per Cent. 1908 1,439 123 8.5 1909 1,579 156 9.9 1910 1,671 152 9.1 1911 1,824 194 10.6 1908-1911 6,513 625 9.6 Mortality from Cancer, by Organs and Parts 1908-1911 Deaths from Cancer Organ Cancer Per Cent. Stomach, liver and abdomen 333 5.1 Other organs 292 4.5 AU organs 625 9.6 Source: Annual Reports of Die Lebensversichenmgs-Anstalt und Sterbekasse des Deutschen Kriegerbundes, Berlin. Table 66 Mortality Experience of the German Life Insurance Company Potsdam, Germany Mortality from Cancer, by Age 1907-1912 Deaths Deaths from All from Cancer Ages Causes Cancer Per Cent. 30 and under. 80 3 3.8 31-40 354 17 4.8 41-50 633 74 11.7 51-60 914 125 13.7 61-70 1,181 199 16.9 71 and over... 930 92 9.9 Total 4,092 510 12.5 Source: Annual Reports of Die Deutsche Lebensversicherung, Potsdam. Table 67 Mortality Experience of the Bremen- Hanoveranian Life Insurance Com- pany' "Freia," Hanover, Germany Mortality from Cancer, by Age 1907-1913 Ages Deaths from All Causes Deaths from Cancer Cancer Per Cent 30 and under . 158 2 1.3 31-60 2,112 183 8.7 61-70 926 140 15.1 71 and over.. . 785 62 7.9 Total. 3,981 387 9.7 Source: Annual Reports of "Freia," Bremen-Hannoversche Lebensversicher- ungs-Bank, Hanover. 377 APPEXDIX D Table 68 Ordinary Mortality Experience of the "Friedrich Wilhelm" Life Insurance Company, Germany Mortality from Cancer, 1885-1913 Year Deaths from All Causes Deaths from Cancer Cancer Per Cent. 1885 426 36 8.5 1886 434 35 8.1 1887 497 59 11.9 1888 492 54 11.0 1889 508 73 14.4 1890 507 50 9.9 1891 329 33 10.0 1892 338 27 8.0 1893 385 31 8.1 1894 355 43 441 12.1 1885-1894 4,271 10.3 1895 382 41 10.7 1896 368 39 10.6 1897 410 48 11.7 1898 395 42 10.6 1899 463 54 11.7 1900 431 49 11.4 1901 508 60 11.8 1902 533 56 10.5 1903 556 72 12.9 1904 540 59 520 10.9 1895-1904 4,586 11.3 1905 516 55 10.7 1906 567 65 11.5 1907 604 69 11.4 1908 640 53 8.3 1909 666 69 10.4 1910 675 71 10.5 1911 750 71 9.5 1912 862 88 10.2 1913 848 93 634 11.0 1905-1913 6,128 10.3 Source: Zeitschrift fiir Kxebsforschung.Yol. III. Friedrich Wilhelm Lebensversicherungs-Actiengesellschaft in Berlin. Geschaftsbericht. 378 APPENDIX D Table 69 Ordinary Mortality Experience of the "Friedrich Wilhelm" Life Insurance Company, Germany Mortality from Cancer, by Organs and Parts, according to Sex 1885-1899 MALES Deaths from Per Organ or Part Cancer Cent. Lips Nose Tongue 10 2.1 (Esophagus 48 9.9 Stomach 216 44.6 Intestines 59 12.2 Liver 65 13.4 Larynx 16 3.3 Lungs 4 0.8 Breast 3 0.6 Bladder." 7 1.5 Prostate 3 0.6 Kidneys 3 0.6 Uterus Bones 10 2.1 Other organs 40 8.3 All organs 484 100.0 Source: Zeitschrift fiir Krebsforschung, Vol. III. FEMALES Deaths from Per Cancer Cent. 3 1.6 56 30.9 10 6.5 24 13.3 0.6 " * 4.4 0.6 '2 i.i 63 34.8 1 0.6 12 6.6 181 100.0 Life Insurance Table 70 Ordinary Mortality Experience of the "Friedrich Wilhelm' Company, Germany Mortality from Cancer, by Age and Sex 1885-1899 MALES FEMALES Ages Deaths from Cancer Per Cent. Deaths from Cancer Per Cent 20-29 4 0.8 1 0.6 30-39 24 5.0 11 6.1 40-49 104 21.5 46 25.4 50-59 170 35.1 69 38.1 60-69 143 29.5 38 21.0 70-79 38 7.9 16 8.8 80 and over 1 0.2 Total 484 100.0 181 100.0 379 APPENDIX D Table 71 Industrial Mortality Experience of the "Friedrich Wilhelm" Life Insurance Company, Germany Mortality from Cancer, by Sex 1885-1899 MALES Deaths Deaths from All from Cancer Year Causes Cancer Per Cent. 1885 326 12 3.7 1886 520 23 4.4 1887 553 22 4.0 1888 431 38 8.8 1889 833 55 6.6 1885-1889 2,663 150 5.6 1890 1,062 64 6.0 1891 1,309 100 7.6 1892 1,441 110 7.6 1893 1,826 113 6.2 1894 2,180 182 8.3 1890-1894 7,818 569 7.3 1895 2,721 229 8.4 1896 3,287 299 9.1 1897 3,930 349 8.9 1898 4,712 409 8.7 1899 5,952 475 8.0 1895-1899 20,602 1,761 8.5 Source: Zeitschrift fiir Krebsforschung, Vol. III. FEMALES Deaths Deaths from All from Cancer Causes Cancer Per Cent 325 37 11.4 400 38 9.5 491 58 11.8 438 50 11.4 802 98 12.2 2,456 281 11.4 980 111 11.3 1,307 174 13.3 1,603 207 12.9 1,864 210 11.3 2,192 289 13.2 7,946 991 12.5 2,644 344 13.0 3,285 434 13.2 3,770 543 14.4 4,634 624 13.5 5,827 719 12.3 20,160 2.664 13.2 380 APPENDIX D Table 72 Industrial Mortality Experience of the "Friedrich Wilhelm" Life Insurance Company, Germany Mortality from Cancer, by Organs and Parts, according to Sex 1885-1899 MALES Deaths from Per Organ or Part Cancer Cent. Lips 5 0.2 Nose ; 2 0.1 Tongue 23 0.9 (Esophagus 267 10.8 Stomach 1,580 63.7 Intestines 120 4.8 Liver 222 9.0 Larynx 27 1.1 Lungs 12 0.5 Breast 7 0.3 Bladder 36 1.4 Prostate 3 0.1 Kidneys 4 0.2 Uterus Bones 15 0.6 Other organs 157 6.3 Allorgans 2,480 100.0 Source: Zeitschrift fiir Krebsforschung, Vol. III. FEMALES Deaths from Per Cancer Cent. 1 0.0 2 0.1 2 0.1 68 1.7 1,503 38.2 161 4.1 413 10.5 17 0.4 9 0.2 205 5.2 24 0.6 9 0.2 1,287 32.7 20 0.5 215 5.5 3,936 100.0 Table 73 Industrial Mortality Experience of the "Friedrich Wilhelm" Life Insurance Company, Germany Mortality from Cancer, by Age and Sex 1885-1899 MALES Deaths from Per Ages Cancer Cent. 20-29 6 0.2 30-39 70 2.8 40-49 390 15.7 50-59 1,140 46.0 60-69 821 33.1 70-79 62 2.1 80 and over 1 0.1 Total 2,480 100.0 Source: Zeitschrift fiir Krebsforschung, Vol. III. FEMALES Deaths from Per Cancer Cent 15 0.4 166 4.2 746 18.9 1,755 44.6 1,154 29.3 98 2.5 2 0.1 3,936 100.0 38] APPENDIX D Table 74 Mortality Experience of the German Life Insurance Company, Liibeck Mortality from Cancer, by Sex 1906-1913 MALES FEMALES Deaths Deaths Deaths Deaths from All from Cancer from All from Cancer Year Causes Cancer Per Cent. Causes Cancer Per Cent. 1906 790 97 12.3 79 12 15.2 1907 770 84 10.9 88 7 8.0 1908 768 72 9.4 101 13- 12.9 1909 755 87 11.5 89 12 13.5 1910 726 93 12.8 82 10 12.2 1911 728 91 12.5 83 11 13.3 1912 768 79 10.3 91 16 17.6 1913 724 94 13.0 87 13 14.9 1906-1913 6,029 697 11.6 700 94 13.4 Table 75 Mortality Experience of the "Germania" Life Insurance Company, Germany Mortality from Cancer, by Age and Sex 1857-1894 MALES Ages Number of Lives Exposed to Risk One Year Under 26 41,661.5 26-30 178,126.0 31-35 315,234.5 36-40 361,870.5 41-45 340,411.0 46-50 284,106.5 51-55 213,976.5 56-60 141,419.5 61-65 79,587.5 66-70 37,493.5 71 and over 18,529.5 Total 2,012,416.5 FEMALES Under 26 29,502.5 26-30 74,549.5 31-35 109,396.0 36-40 119,658.0 41-45 115,751.5 46-50 102,250.5 51-55 56-60 Cl-65 66-70 71 and over. 81,023.5 55,916.0 33,335.0 17,138.5 10,638.0 Deaths from Cancer and Tumor 1 11 50 120 227 399 484 498 449 297 147 2,683 2 13 33 83 196 245 245 235 192 95 85 Rate per 100,000 Exposed 2.4 6.2 15.9 33.2 66.7 140.4 226.2 352.1 564.2 792.1 793.3 133.3 6.8 17.4 30.2 69.4 169.3 239.6 302.4 420.3 576.0 554.3 799.0 Total 749,159.0 1,424 190.1 Source: Untersuchimgen iiber die Sterblichkeit unter den Versicherten der "Ger- mania," Lebensversicherungs-Aktien-Gesellschaft zu Stettin. Berlin, 1897. 382 APPENDIX D Table 76 Mortality Experience of the Gotha Life Insurance Company, Germany Mortality from Cancer by Age, Males 1829-1878 Number of Ages Lives Exposed to Risk 15-20 714.5 21-25 7,174.0 26-30 40,574.0 31-35 97,948.5 36-40 141,078.5 41-45 156,854.0 46-50 148,165.0 51-55 128,034.5 56-60 99,884.0 61-65 69,231.0 66-70 42,108.5 71-75 21,253.5 76-80 8,288.0 81-85 2,339.5 86-90 325.5 Total 963,973.0 Deaths from Cancer Rate per 100,000 Exposed k 4.9 11 11.2 40 28.4 80 51.0 141 95.2 168 131.2 226 226.3 271 391.4 207 491.6 122 574.0 41 494.7 13 555.7 1,322 137.1 Source: Aus der Praxis der Gothaer Lebensversicherungsbank. Jena, 1902. Table 77 Mortality Experience of the Gotha Life Insurance Company, Germany Mortality from Cancer, by Age and Duration of Insurance, Males 1829-1896 15-25 26-30 31-35 36-40 41-45 46-50 51-55 56-60 61-65 66-70 71-75 76-80 81-85 86-90 Total Source: Aus der Praxis der Gothaer Lebensversicherungsbank. Jena, 1902. 1st to 5th 6th and Insurance Years Si ibsequent Years Deaths Deaths Deaths Deaths from All from Cancer from All from Cancer Causes Cancer Per Cent. Causes Cancer Per Cent 127 19 403 1 0.2 88 , , , , 767 9 1.2 506 8 1.6 867 22 2.5 1,350 58 4.3 755 44 5.8 2,429 135 5.6 599 31 5.2 3,422 274 8.0 495 29 5.9 4,452 397 8.9 382 35 9.2 5,361 537 10.0 157 15 9.6 5,836 634 10.9 29 3 10.3 5,750 541 9.6 1 4,679 385 8.2 3,082 150 4.9 1,442 53 3.7 189 4.1 382 7 1.8 4,582 38,798 3,179 8.2 383 26 APPENDIX D Table 78 Mortality Experience of the Gotha Life Insurance Company, Germany Mortality from Cancer, by Age 1903-1912 1903-1907 1908-1912 Deaths Deaths Deaths Deaths from All from Cancer from All from Cancer Ages Causes Cancer Per Cent. Causes Cancer Per Cent. 15-30 142 6 4.2 165 6 3.6 31-35 209 6 2.9 247 10 4.0 36-40 344 26 7.6 361 22 6.1 41-45 523 51 9.8 525 56 10.7 46-50 741 92 12.4 773 92 11.9 51-55 895 143 16.0 1,031 168 16.3 56-60 1,175 182 15.5 1,153 190 16.5 61-65 1,321 206 15.6 1,330 216 16.2 66-70 1,445 230 15.9 1,439 236 16.4 71-75 1,175 145 12.3 1,359 172 12.7 76-80 967 98 10.1 1,074 94 8.8 81-85 565 28 5.0 635 29 4.6 86-90 201 5 2.5 12.6 235 9 3.8 Total 9,703 1,218 10,327 1,300 12.6 Ages 15-30. 31-35. 36-40. 41-45. 46-50. 51-55. 56-60. 61-65. 66-70. 71-75. 76-80. 81-85. 86-90. Deaths from All Causes 307 456 705 1,048 1,514 1,926 2,328 2,651 2,884 2,534 2,041 1,200 436 1903-1912 Deaths from Cancer 12 16 48 107 184 311 372 422 466 317 192 57 14 Cancer Per Cent, 3.9 3.5 6.8 10.2 12.2 16.1 16.0 15.9 16.2 12.5 9.4 4.8 3.2 Total 20,030 2,518 12.6 Source: Original data furnished by the Gothaer Lebensversicherungsbank, Gotha. 384 APPENDIX D Table 79 Mortality Experience of the Gotha Life Insurance Company, Germany Mortality from Cancer among Teachers 1829-1890 Number of Deaths Lives Exposed from to Risk Cancer School-teachers Ages 21-45 82,213.0 22 46-60 54,770.5 93 61-90 22,885.0 112 All ages 159,868.5 227 High-school Teachers Ages 26-45 32,247.0 13 46-60 20,687.0 31 61-90 9,014.5 39 All ages 61,948.5 83 University Professors 7,814.5 10 Professors of Medicine 2,792.0 5 Source: Aus der Praxis der Gothaer Lebensversicherungsbank. Jena, 1902. Rate per 100,000 Exposed 26.8 169.8 489.4 142.0 40.3 149.9 432.6 134.0 128.0 179.1 Table 80 Mortality Experience of the Karlsruhe Life Insurance Company, Germany Mortality from Cancer 1910-1913 Year Deaths from All Causes Deaths from Cancer Cancer Per Cent. 1910 1911 1912 1913 . . . 1,436 . . . 1,554 . . . 1,535 . . . 1,564 169 195 230 256 11.8 12.5 15.0 16.4 1910-1913... 6.089 850 14.0 Source: Correspondence from Karls- ruher Lebensversicherung, Karlsruhe. 385 APPENDIX D Table 81 Mortality Experience of the Karlsruhe Life Insurance Company, Germany Mortality from Cancer, by Organs and Parts, according to Age 1910-1913 Per Cent. Under 71 and All of All Organ or Part 30 31-40 41-50 51-60 61-70 Over Ages Organs Tongue 3 2 .. 3 8 0.9 Larynx 3 6 5 2 16 1.9 (Esophagus and stomach 2 22 76 144 117 G8 399 46.9 Intestines 10 21 60 51 25 167 19.7 Liver .... 5 10 26 26 10 77 9.1 Breast 2 4 2 .. 8 0.9 Uterus 4 2 2 8 0.9 Other organs 1 8 25 54 49 30 167 19.7 All organs 3 45 140 300 252 110 850 Per cent, of all ages. 0.4 5.3 16.5 35.3 29.6 12.9 .. 100.0 Source: Original data furnished by the Karlsruher Lebensversicherung, Karlsruhe. Table 82 Mortality Experience of the Karlsruhe Life Insurance Company, Germany Mortality from Cancer, by Organs and Parts 1900-1905 Deaths Organ or Part from Per Cent. Cancer Tongue 12 1.7 Larynx 17 2.3 CEsophagus and stomach 347 48.0 Intestines 134 18.5 Liver 93 12.9 Breast 8 1.1 Uterus 20 2.8 Otherorgans 92 12.7 All organs 723 100.0 Source: Annual Reports of Karlsruher Lebensversicherung, Karlsruhe. 386 APPENDIX D Table 83 Mortality Experience of the Karlsruhe Life Insurance Company, Germany Mortality from Cancer, by Age, 1900-1905 Deaths Deaths from All from Cancer Ages Causes Cancer Per Cent. 20 and under. 5 21-25 67 2 3.0 26-30 223 2 0.9 31-35 368 10 2.7 36-40 569 26 4.6 41-45 784 59 7.5 46-50 915 109 11.9 51-55 1,040 146 14.0 56-60 1,008 155 15.4 61-65 776 109 14.0 66-70 537 60 11.2 71-75 329 31 9.4 76-80 127 12 9.4 Above 80 42 2 4.8 Total 6,790 723 10.6 Source: Annual Reports of the Karls- ruher Lebensversicherung, Karlsruhe. Table 84 Mortality Experience of the Leipzig Life Insurance Company, Germany Mortality from Cancer, by Sex, 1893-1913 MALES FEMALES Deaths Deaths Deaths Deaths from All from Cancer from All from Cancer Years Causes Cancer Per Cent. Causes Cancer Per Cent. 1893 752 86 11.4 46 5 10.9 1894 743 75 10.1 40 5 12.5 1895 785 83 10.6 60 7 11.7 1896 829 91 11.0 34 5 14.7 1897 797 96 12.0 38 4 10.5 1898 847 94 11.1 60 10 16.7 1899 869 100 11.5 42 5 11.9 1900 936 111 11.9 34 3 8.8 1901 927 126 13.6 43 6 14.0 1902 1,016 137 13.5 43 8 18.6 1903 1,062 132 12.4 55 14 25.5 1904 1,043 142 13.6 47 3 6.4 1905 1,115 117 10.5 52 8 15.4 1906 1,120 141 12.6 39 5 12.8 1907 1,196 169 14.1 36 5 13.9 1908 1,213 151 12.4 47 6 12.8 1909 1,189 148 12.4 43 6 14.0 1910 1,253 159 12.7 41 2 4.9 1911 1,277 158 12.4 41 4 9.8 1912 1,263 163 12.9 47 7 14.9 1913 1,302 168 12.9 11.8 34 495 5 72 14.7 1893-1903 9,563 1,131 14.6 1904-1913 11,971 1,516 12.7 427 51 11.9 Source: Annual Reports of the Leipziger Lebensversicherungs-Gesellschaft, Leipzig. 387 APPENDIX D Table 85 Mortality Experience of the Leipzig Life Insurance Company, Germany Mortality from Cancer, according to Age, Males 1893-1912 Ages 15-30. 31-40. 41-50. 51-60. 61-70. 71-85. 1893-1902 1903-1912 Deaths Deaths Deaths Deaths from All from Cancer from All from Cancer Causes Cancer Per Cent. Causes Cancer Per Cent 174 7 4.0 272 6 2.2 817 42 5.1 986 66 6.7 1,766 180 10.2 2,152 223 10.4 2,458 352 14.3 3,110 486 15.6 2,018 288 14.3 2,958 473 16.0 1,268 130 10.3 2,253 226 10.0 Total 8,501 999 11.8 11,731 1,480 12.6 Source: Annual Reports of the Leipziger Lebensversicherungs-Gesellschaft, Leipzig. Table 86 Mortality Experience of the Magde- burg Life Insurance Company Germany Mortality from Cancer 1901-1913 Year Deaths from All Causes Deaths from Cancer Cancer Per Cent 1901 736 57 7.7 1902 740 64 8.6 1903 807 78 9.7 1904 699 59 8.4 1905 750 76 10.1 1906 703 82 11.7 1907 762 91 11.9 1908 803 69 8.6 1909 742 72 9.7 1910 815 92 11.3 1911 890 93 10.4 1912 885 94 10.6 1913 883 112 12.7 1901-1913. 10,215 1,039 10.2 Source : Annual Reports of the Magde- burger Lebensversicherungs-Gesellschaft, Magdeburg. Table 87 Mortality Experience of the Magde- burg Life Insurance Company Germany Mortality from Cancer, by Age 1901-1913 Deaths from All Ages Causes Under 30 247 30-39 1,199 40-49 2,010 50-59 2,241 60-69 2,117 70 and over... 2,401 Total 10,215 Deaths from Cancer 160 323 211 1,039 Cancer Per Cent. 0.4 4.3 8.0 13.0 15.3 10.2 Source: Annual Reports of the Magde- Ijurger Lebensversicherungs-Gesellschaft, Magdeburg. APPEXDIX D Table 88 Mortality Experience of the Saxon Military Life Insurance Society Dresden, Germany Mortality from Cancer, by Organs and Parts, according to Sex 1903-1906 MALES Organ or Part Tongue Larynx (Esophagus Stomach Liver Intestines Kidney and bladder. Lungs Breast Uterus and ovary. . . Other organs Deaths from Cancer 4 2 8 64 13 16 5 Per Cent. 3.2 1.6 6.3 50.8 10.3 12.7 4.0 4.0 7.1 All organs 126 100.0 FEMALES Deaths from Cancer Per Cent. 2 1.9 47 45.2 7 6.7 4.8 i 1.6 4 3.8 28 26.9 10 9.7 104 100.0 Males. . . Females . MORTALITY FROM CANCER, BY SEX, 1903-1906 Deaths from All Causes Deaths from Cancer Cancer Per Cent. 1,545 126 8.2 874 104 11.9 Source: Total... 2,419 230 9.5 Annual Reports of Sachsischer Militar Lebensversichenmgs-Verein, Dresden. Table 89 Table 90 Mortality Experience of the Stutt- Mortality Experience of the "Teu- gart Life Insurance Comp any tonia" Life Insurance Company Germany Germany Mortality from Cancer, by Age Mortality from Cancer, by Age 1901-1906 )eaths 1905-191 2 Deaths Deaths r Deaths from All rom Cancer from AU from Cancer Ages Causes Cancer Per Cent. Ages Causes Cancer Per Cent. Under 30 . 215 4 1.9 20-30 165 1 0.6 30-34 259 11 4.2 31-40 681 39 5.7 35-39 432 28 6.5 41-50 1,234 126 10.2 40-44 560 43 7.7 51-60 1,760 245 13.9 45-49 715 90 12.6 61-70 2,602 428 16.4 50-54 833 99 11.9 71-80 2,503 298 11.9 55—59 .... 890 143 16.1 81 and over... 835 29 3.5 60-64 879 141 16.0 65-69 742 105 14.2 Total 9.780 1,166 11.9 70-74.... 675 96 14.2 75-79 426 32 7.5 Source: Annual Report s of the Teutonia 80-89 327 25 817 7.6 11.8 Versicherungs-Actien-Gesellschaft, Leipzig. Total . . . . . 6,953 Source: Annual Report s of the Stutt- garter Lebensversicherungsbank, Stuttgart. 389 APPENDIX D Table 91 Mortality Experience of the "Victoria" Life Insurance Company, Berlin Mortality from Cancer, 1903-1913 Deaths from All Year Causes 1903 861 1904 1,014 1905 1,103 1906 1,218 1907 1,247 1908 1,434 1909 1,522 1910 1,515 1911 1,783 1912 1,890 1913 2,146 Deaths from Cancer Cancer Per Cent. 73 8.5 87 8.6 91 8.3 104 8.5 101 8.1 121 8.4 127 8.3 142 9.4 153 8.6 180 9.5 206 9.6 1903-1913... 15,733 1,385 8.8 Source: Annual Reports of the "Vic- toria zu Berlin," Berlin. Table 92 Mortality Experience of Austrian Life Insurance Companies Mortality from Cancer, 1899-1912 Deaths Number of from All Year Companies Causes 1899 2 1,495 1900 , 4 3,048 1901 6 4,499 1902 6 4,401 1903 5 3,755 1904 7 4,553 1905 8 5,481 1906 9 5,467 1907 12 7,820 1908 12 8,362 1909 13 9,371 1910 13 9,294 1911 13 9,795 1912 13 9,979 1899-1912 87,320 8,234 9.4 Source: Annual Reports of the several companies. Deaths from Cancer Cancer Per Cent, 129 8.6 316 10.4 398 ' 8.8 396 9.0 413 11.0 455 10.0 479 8.7 550 10.1 736 9.4 767 9.2 827 8.8 871 9.4 920 9.4 977 9,8 390 APPENDIX D Table 93 Mortality Experience of Austrian Life Insurance Companies Mortality from Cancer, by Age 1899-1912 Deaths Deaths from All from Cancer • Ages Causes Cancer Per Cent. Under 31 4,498 67 1.5 31-35 4,802 156 3.2 36-40 6,933 348 5.0 41-45 8,703 582 6.7 46-50 9,875 1,015 10.3 51-55 ! . . 10,107 1,233 12.2 56-60 10,218 1,387 13.6 61-65 9,352 1,326 14.2 66-70 7,988 1,041 13.0 71-75 6,478 640 9.9 76-80 4,840 328 6.8 81-85 2,759 98 3.6 86 and over... 767 13 1.7 Total 87,320 8,234 9.4 Source: Annual Reports of the several companies. Table 94 Mortality Experience of Austrian Life Insurance Companies Mortality from Cancer, according to Age 1876-1890 Compared with 1891-1900 1876-1890 1891-1900 Deaths Deaths Deaths Deaths from Ail from Cancer from All from Cancer Ages Causes Cancer Per Cent. Causes Cancer Per Cent. 17-29 473 2 0.4 580 8 1.4 30-34 1,103 27 2.4 1,299 38 2.9 35-39 1,802 89 4.9 2,244 94 4.2 40-44 2,481 146 5.9 3,094 193 6.2 45-49 2,907 247 8.5 3,722 365 9.8 50-54 3,235 274 8.5 3,852 456 11.8 55-59 3,536 365 10.3 3,883 482 12.4 60-64 3,410 316 9.3 3,255 417 12.8 65-69 3,009 258 8.6 3,132 395 12.6 70-74 1,669 164 9.8 2,006 215 10.7 75-79 1,070 45 4.2 1,684 112 6.7 80-84 425 6 1.4 789 33 4.2 85-98 75 2 2.7 7.7 150 2 1.3 Total 25,195 1,941 29,690 2,810 9.5 Source: Versichenmgswissenschaftliche Mitteilungen, IX. Band, l.Heft. Vienna, 1914. 391 APPENDIX D Table 95 Mortality Experience of Austrian Life Insurance Companies, 1876-1900 Probability of Death from Cancer Multiplied by 100,000 Ages 1876-1880 17-29 30-34 20.37 35-39 56.28 40-44 78.70 45-49 152.27 50-54 243.81 55-59 298.82 60-64 346.91 65-69 553.88 70-74 999.48 75-79 64.02 80-84 85-98 1881-1885 1886-1890 1891-1895 1896-1900 5.33 12.18 2.04 24.15 14.36 19.92 11.39 50.09 38.56 39.84 21.25 95.47 55.95 69.86 50.03 166.03 126.86 160.97 107.22 171.47 206.42 262.79 189.57 334.19 362.41 368.29 327.43 395.76 455.04 519.90 446.88 503.06 576.39 804.91 668.88 940.54 824.59 818.44 886.88 654.35 623.06 608.54 934.40 511.04 169.96 807.13 694.01 1284.16* 435.96 Source: YersicherungswissenschaftlicheMitteilungen, IX. Band, 1. Heft. Vienna, 1914. *Based on only two deaths. Table 96 Mortality Experience of "Der Anker" Life Insurance Company Vienna, Austria Mortality from Cancer, by Age 1901-1913 Ages Deaths from All Causes Deaths from Cancer Cancer Per Cent 30 and under . 1,034 22 2.1 31-35 415 13 3.1 36-40 581 17 2.9 41-45 782 40 5.1 46-50 871 65 7.5 51-55 914 89 9.7 56-60 775 80 10.3 61-65 690 78 11.3 66-70 603 70 11.6 71-75 612 24 3.9 76-80 428 12 2.8 81-85 302 4 1.3 86 and over. . . 151 514 Total 8,158 6.3 Source: Annual Reports of the Life In- surance Company "Der Aaker," Vienna. Note: 1903 is missing. Table 97 Mortality Experience of the" Assicur- azioni Generali," Trieste, Austria Mortality from Cancer 1899-1912 Deaths from All Year Causes 1899 943 1900 895 1901 947 1902 1,035 1903 1,063 1904 1,016 1905 1,145 1906 1,075 1907 1,192 1908 1,209 1909 1,292 1910 1,238 1911 1,295 1912 1,277 Total 15,622 Deaths from Cancer Cancer Per Cent 77 8.2 90 10.1 92 9.7 97 9.4 93 8.7 94 9.3 107 9.3 101 9.4 137 11.5 120 9.9 114 8.8 123 9.9 102 7.9 114 8.9 1,461 9.4 Source : Annual Reports of the " Assicura- zioni Generali," Trieste. 392 APPENDIX D Table 98 Table 99 Mortality Experience of the "Assi- Mortality Experience of th e Life curazioni Generali," Trieste, Austria Insurance Company "Donau," Mortality from Cancer, by Age Vienna, Austria 1899-1912 Mortality from Cancer, by Age 1908-1912 Deaths from All Deaths from Cancer Dfeaths Deaths Ages Causes Cancer Per Cent. from All rom Cancer 30 and under . 579 13 2.2 Ages Causes Cancer Per Cent. 31-35 836 36 4.3 30 and under . 72 1 1.4 36-40 1,270 63 5.0 31-35 117 6 5.1 41-45 1,660 115 6.9 36-40 156 7 4.5 46-50 1,850 194 10.5 41-45 175 10 5.7 51-55 1,782 213 12.0 46-50 250 22 8.8 56-60 1,672 233 13.9 51-55 248 34 13.7 61-65 1,408 192 13.6 56-60 272 40 14.7 66-70 1,337 159 11.9 61-65 261 45 17.2 71-75 1,303 121 9.3 66-70 214 27 12.6 76-80 1,150 86 7.5 71-75 172 25 14.5 81-85 692 32 4.6 76-80 136 10 7.4 86 and over. . . 83 4 4.8 9.4 81 and over.. . Total 91 227 Total 15,622 1,461 2,164 10.5 Source: Annual Reports of the " Assicura- Source: Annual Reports > of the Life In- zioni Generali, ' Trieste. surance Company "Donau, ' Vienna. Table 100 Table 101 Mortality Experience of the First Mortality Experience of the General Association of Mutual Life Insurance Company Austro-Hungarian Ofificials "Janus ," Vienna, Austria Vienna, Austria Mortality from Cancer, by Age Mortality from Cancer, by Age 1907-1912 1900-191^ Deaths Deaths from AU from Cancer from All from Cancer Ages Causes ^ancer Per Cent. Age3 Causes Cancer Per Cent. 30 and under . 125 4 3.2 30 and under . 279 3 1.1 31-35 216 9 4.2 31-35 581 12 2.1 36-40 255 17 6.7 36-40 939 37 3.9 41-45 331 30 9.1 41-45 1,283 86 6.7 46-50 364 46 12.6 46-50 1,649 182 11.0 51-55 387 51 14.7 51-55 2,104 267 12.7 56-60 388 59 15.2 56-60 2,559 380 14.8 61-65 346 44 12.7 61-65 2,569 391 15.2 66-70 350 45 12.9 66-70 2,259 328 14.5 71-75 330 25 7.6 71-75 1,668 203 12.2 76-80 284 22 7.7 76-80 1,085 85 7.8 81-85 162 8 4.9 81-85 86 and over. . . 532 26 4.9 86 and over. . . 140 4 2.9 Total 3,678 370 10.1 Total 17,507 2,000 11.4 Soiu-ce: Annual ReDorts of the Mutual Source : Annual Reports of Erster Allge- Life Insurance Company ".Janus." Vienna. meiner Beamten-Verein der Osterreichisch- Ungarischen Monarchic Wien. 393 APPENDIX D Table 102 Mortality Experience of the Life Insurance Company of the "Mar- graviate Moravia," Briinn, Austria Mortality from Cancer, by Age 1906-1912 Deaths Deaths from All from Cancer Ages Causes Cancer Per Cent. 30 and under . 195 2 1.0 31-35 183 2 1.1 36-40 269 12 4.5 41-45 238 19 8.0 46-50 228 20 8.8 51-55 159 25 15.7 56-60 117 12 10.3 61-65 54 8 14.8 66-70 21 4 19.0 71 and over.. . 2 104 Total 1,466 7.1 Source: Annual Reports of the Landes- Lebensversicherung.s-Anstalt der Mark- grafschaft Mahren, Briinn. Table 103 Mortality Experience of the Mutual Life Insurance Company of Krakau, Austria Mortality from Cancer, by Age 1905-1912 Deaths Deaths from All from Cancer Ages Causes Cancer Per Cent. 30 and under. 82 3 3.7 31-35 197 6 3.0 36-40 420 20 4.8 41-45 570 40 7.0 46-50 597 46 7.7 51-55 604 52 8.6 56-60 524 68 13.0 61-65 507 76 15.0 66-70 324 40 12.4 71-75 184 26 14.1 76-80 118 8 6.8 81 and over.. . 47 Total 4,174 385 9.2 Source: Annual Reports of the Krakau Mutual Life Insurance Company, Krakau. Table 104 Mortality Experience of the 'Phoenix" Life insurance Company Vienna, Austria Mortality from Cancer 1901-1913 Deaths Deaths from All from Cancer Year Causes Cancer Per Cent. 1901 729 38 5.2 1902 785 5Q 7.1 1903 774 87 11.2 1904 790 73 9.2 1905 915 73 8.0 1906 873 85 9.7 1907 929 100 10.8 1908 963 110 11.4 1909 1,016 102 10.0 1910 1,001 84 8.4 1911 954 93 9.7 1912 895 107 12.0 1913 847 80 9.4 Total 11,471 1,088 9.5 Source: Annual Reports of the Oster- reichischer Phoenix, Vienna. 394 APPENDIX D Table 105 Mortality Experience of the "Phoenix" Life Insurance Company Vienna, Austria Mortality from Cancer, by Age 1901-1912 1901-1906 1907-1912 Ages Deaths from All Causes Deaths from Cancer Cancer Per Cent. Deaths from All Causes Deaths from Cancer Cancer Per Cent. 30 and under 142 2 2 1.4 0.8 160 262 2 9 1.3 31-35 237 3.4 36-40 312 14 4.5 402 30 7.5 41-45 408 22 5.4 462 24 5.2 46-50 517 51 9.9 581 57 9.8 51-55 538 57 10.6 555 76 13.7 56-60 604 67 11.1 659 82 12.4 61-65 625 81 13.0 714 105 14.7 66-70 552 52 9.4 718 111 15.5 71-75 428 45 10.5 570 65 11.4 76-80 312 16 5.1 382 26 6.8 81-85 141 3 2.1 217 8 3.7 86 and over 50 412 8.5 76 1 596 1.3 Total 4,866 5,758 10.4 Source: Annual Reports of the Osterreichischer Phoenix, Vienna. Table 106 Mortality Experience of the "Praha" Mutual Life Insurance Company Prague, Austria Mortality from Cancer, by Age 1900-1907 Deaths Deaths from All from Cancer Ages Causes Cancer Per Cent. 30 and under. 97 1 1.0 31-35 123 5 4.1 36-40 140 7 5.0 41-45 170 9 5.3 46-50 185 26 14.1 51-55 156 26 16.7 56-60 145 20 13.8 61-65 157 21 13.4 66-70 135 16 11.9 71-75 79 3 3.8 76-80 30 4 13.3 81-85 7 86 and over.. . Total 1,424 138 9.7 Source: Annual Reports of the Mutual Life Insurance Company "Praha," Prague, Bohemia. Table 107 Mortality Experience of the" Riunione Adriatica Sicurta" Life Insurance Company, Trieste, Austria Mortality from Cancer, by Age 1899-1912 Deaths Deaths from All from Cancer Ages Causes Cancer Per Cent 30 and under . 305 6 2.0 31-35 495 15 3.0 36-40 721 42 5.8 41-45 1,040 73 7.0 46-50 1,142 120 10.5 51-55 1,165 123 10.6 56-60 1,113 130 11.7 61-65 904 100 11.1 66-70 786 94 12.0 71-75 694 59 8.5 76-80 586 36 6.1 81-85 372 11 3.0 86 and over.. . 131 2 1.5 Total 9,454 811 8.6 Source: Annual Reports of the "Riunione Adriatica Sicurta," Trieste. 395 APPENDIX D Table 108 Mortality Experience of the Industrial Insurance Company "Universale," Vienna, Austria Mortality from Cancer, by Age 1907-1912 Deaths from All Ages Causes 30 and under. 1,084 31-35 680 36-40 819 41-45 902 46-50 949 51-55 947 56-60 914 61-65 820 66-70 520 71-75 345 76-80 290 81-85 216 86 and over... 108 Total 8,594 Deaths from Cancer 6 23 45 60 102 140 146 134 73 37 16 6 2 790 Cancer Per Cent, 0.6 3.4 5.5 6.7 10.7 14.8 16.0 16.3 14.0 10.7 5.5 2.8 1.9 9.2 Source: Annual Reports of the Indus- trial Life Insurance Company "Univer- sale," Vienna. Table 109 Mortality Experience of the "Fonciere" Life Insurance Company Budapest, Hungary Mortality from Cancer, by Age 1900-1912 Deaths from All Ages Causes 30 and under . 134 31-35 159 36-40 311 41-45 397 46-50 476 51-55 419 56-60 420 61-65 303 66-70 246 71-75 147 76-80 69 81-85 30 86 and over... 6 Total 3,117 Deaths from Cancer 2 7 12 32 34 46 48 42 17 10 253 Cancer Per Cent. 1.5 4.4 3.9 8.1 7.1 11.0 11.4 13.9 6.9 6.8 4.3 8.1 Source: Annual Reports of the "Fon- ciere," Pester Versicherungs-Anstalt, Buda- pest, Hungary. Table 110 Mortality Experience of the 'Basle" Life Insurance Company Switzerland, 1865-1897 MORTALITY FROM CANCER Years 1865-1877. 1878-1887. 1888-1897. Deaths from All Causes 1,482 2,332 3,252 Deaths from Cancer 103 190 347 Cancer Per Cent. 6.95 8.15 10.67 1865-1897... 7,066 640 9.06 MORTALITY FROM CANCER, BY SEX Males 5,755 500 8.69 Females . 927 140 15.10 Source: 7066 Todesfalle der Easier Lebensversicherungs-Gesellschaft medi- zinish und statistisch bearbeitet von Dr. Arthur Hesse. Leipzig, 1899. Table 111 Mortality Experience of 'La Suisse" Life Insurance Company Lausanne, Switzerland Mortality from Cancer, by Age 1901-1913 Deaths from All Ages Causes 21-30 41 31-40 162 41-50 225 51-60 269 61-70 274 71-80 225 81-90 57 Total 1,253 Deaths from Cancer 2 7 20 30 36 22 3 129 Cancer Per Cent. 4.9 4.3 8.9 14.5 13.1 9.8 5.3 10.3 Source: Annual Reports of "La Suisse" Societe d'Assurances sur la vie et contre les accidents, Lausanne. 396 APPENDIX D Table 112 Mortality Experience of the Life Insurance Company "Thule" Stockholm, Sweden Mortality from Cancer and Other Tumors 1873-1902 Deaths Deaths from All from Cancer Year Causes Cancer Per Cent. 1873 1 1874 4 i 25.0 1875 12 1876 6 1877 12 1878 14 1879 11 3 27.3 1880 10 1881 18 i 5.6 1882 21 1 4.8 1873-1882 109 6 5.5 1883 24 2 8.3 1884 23 3 13.0 1885 42 3 7.1 1886 32 2 6.3 1887 33 1 3.0 1888 35 4 11.4 1889 40 4 10.0 1890 58 4 6.9 1891 70 3 4.3 1892 86 3 3.5 1883-1892 443 29 6.5 1893 103 9 8.7 1894 97 9 9.3 1895 92 10 10.9 1896 123 15 12.2 1897 152 17 11.2 1898 133 11 8.3 1899 151 15 9.9 1900 . 181 19 10.5 1901 236 25 10.6 1902 201 21 151 10.4 1893-1902 1,469 10.3 Source: Lifsforsakringsaktiebolaget Thule, Trettio Ars Verksamhet, 1873-1902. Stockholm, 397 APPENDIX D Table 113 Mortality Experience of The Australian Mutual Provident Society Mortality from Cancer, by Age and Sex 1849-1888 MALES FEMALES Ages Deaths from All Causes Deaths from Cancer Cancer Per Cent. Deaths from AU Causes Deaths from Cancer Cancer Per Cent. 19-24 204 2 1.0 7 25-29 358 2 0.6 10 80-34 493 7 1.4 23 35-39 628 13 2.1 40 40-44 776 27 3.5 25 4 16.6 45-49 804 42 5.2 20 3 15.0 50-54 705 49 7.0 28 7 25.0 55-59 543 33 6.1 22 5 22.7 60-64 379 30 7.9 17 4 23.5 65-69 269 14 10 5.2 9.5 12 9 2 70-74 105 22.2 75-79 45 3 6.7 6 80 and over 16 2 Total 5,325 232 4.4 221 25 11.3 Source: Report on the Mortality Experience of The Australian Mutual Pro\adent Society for the forty years 1849 to 1888. Table 114 Mortality Experience of The Australian Mutual Provident Society Mortality from Tumor, by Age and Sex 1849-1888 MALES FEMALES Deaths Deaths Deaths Deaths from AU from Tumor from All from Tumor Ages Causes Tumor Per Cent. Causes Tumor Per Cent. 19-24 204 7 25-29 358 10 30-34 493 1 0.2 23 35-39 628 1 0.2 40 40-44 776 2 0.3 25 45-49 804 2 0.2 20 1 5.0 50-54 705 1 0.1 28 55-59 543 1 0.2 22 60-64 379 1- 0.3 17 65-69 269 12 70-74 105 1 1.0 9 75-79 45 6 80 and over 16 2 Total 5,325 10 0.2 221 1 0.5 Source: Report on the Mortality Experience of The Australian Mutual Provident Society for the forty years 1849 to 1888. 398 APPENDIX D Table 115 Mortality Experience of The Oriental Government Security Life Assurance Company Bombay, British India Mortality from Cancer, by Race 1897-1913 Deaths Deaths Deaths Deaths from AU from Cancer from All from Cancer Causes Cancer Per Cent. Ages Causes Cancer Per Cent Hindoos 7,281 70 0.96 Under 40. . . 43 1 2.3 Europeans. . . 840 33 3.93 40-49 43 2 4.7 Parsees 637 12 1.88 50-64 51 11 21.6 Mahomedans 259 1 116 0.39 1.29 65 and over. . Total .... 24 161 1 15 4.2 Total 9,017 9.3 Source: Annual Reports of The Oriental Government Security Life Assurance Com- pany, Limited. Table 116 Mortality Experience of The Dutch East Indian Life Insurance Company Batavia, Dutch East Indies Mortality from Cancer, by Age 1911-1913 Source: Annual Reports of the Neder- landsch-Indische LelDensverzekeringen Li jf rente Maatschappij, Batavia, Dutch East Indies. Table 117 Mortality Experience of the Meiji Life Assurance Company, Japan Mortality from Cancer, by Sex 1899-1907 . Year 1899 1900 1901 1902 1903 1904 1905 1906 1907 1899-1907. 1899-1907. 5,919 IMALES 529 TOTAL 8.9 FEiLALES Deaths from All Causes Deaths from Cancer Cancer Per Cent. Deaths from All Causes Deaths from Cancer Cancer Per Cent 417 33 7.9 91 9 9.9 443 32 7.2 95 11 11.6 505 39 7.7 104 13 12.5 618 62 10.0 180 18 10.0 615 64 10.4 160 24 15.0 787 56 7.1 180 31 17.2 851 90 10.6 210 20 9.5 743 70 9.4 238 27 11.3 940 83 8.8 296 27 9.1 1,554 180 Deaths Deaths from All from Cancer Causes Cancer Per Cent 7,473 709 9.5 11.6 Source: Mortality Experience in the Meiji Life Assurance Company, 1899 to 1907. 399 APPENDIX D Table 118 Mortality Experience of the Meiji Life Assurance Company, Japan Mortality from Carcinoma, by Age and Sex 1899-1907 Total Males Females Number of Number of Number of Ages Deaths Per Cent. Deaths Per Cent. Deaths Per Cent, 25-29 3 0.4 2 0.4 1 0.6 30-34 11 1.6 4 0.8 7 4.0 35-39 36 5.2 18 3.5 18 10.2 40-44 72 10.4 49 9.5 23 13.0 45-49 114 16.4 85 16.4 29 16.4 50-54 153 22.0 125 24.1 28 15.8 55—59 149 21.4 115 22.2 34 19.2 60-64 106 15.3 83 16.0 23 13.0 65-69 36 5.2 28 5.4 8 4.5 70-74 15 2.2 9 1.7 6 3.4 Total 695 100.0 518 100.0 177 100.0 Source: Mortality Experience in the Meiji Life Assurance Company, 1899 to 1907. Table 119 Mortality Experience of the Meiji Life Assurance Company, Japan Mortality from Cancer, by Organs and Parts, according to Sex 1899-1907 Total Number of Carcinoma of Deaths Per Cent. Buccal ca\nty 16 2.3 Larj'nx 16 2.3 (Esophagus 88 12.4 Stomach 371 52.3 Liver 52 7.3 Intestines and peritoneum .. . 44 6.2 Kidneys and urethra 7 1.0 Lungs and pleura 5 0.7 Uterus 79 11.1 Breast 4 0.6 Neck 6 0.8 Other organs 7 1.0 Sarcoma 14 2.0 Allorgans 709 100.0 Males Number of Deaths Per Cent. 16 14 85 306 42 33 6 4 6 6 11 529 3.0 2.6 16.1 57.8 7.9 6.2 1.1 0.8 1.1 1.1 2.1 100.0 Females Number of Deaths 3 65 10 11 1 1 79 4 180 Per Cent. i.i 1.7 36.1 5.6 6.1 0.6 0.6 43.9 0.6 1.7 100.0 Source: Mortality Experience in the Meiji Life Assurance Company, 1899 to 1907. 400 APPENDIX D Table 120 Mortality Experience of Domestic Life Insurance Companies of Japan Mortality from Cancer, by Organs and Parts according to Age and Sex, 1910-1912 Ages Deaths from All Causes 20 and under 799 21-30 3,600 31-40 5,863 41-50 7,407 51-60 7,381 61-70 4,543 71-80 800 81-90 9 Total 30,402 MALES Cancer of Stomach Per Cent, of All Causes Deaths 105 376 688 411 49 1 1,638 0.0 0.2 1.8 5.1 9.3 9.0 6.1 11.1 5.4 Cancer of Other Organs Per Cent, of All Causes Deaths 6 40 205 372 217 868 0.0 0.2 0.7 2.8 5.0 4.8 3.5 0.0 Deaths Cancer of All Organs Per Cent, of All Causes 0.0 0.4 2.5 7.9 14.3 13.8 9.6 11.1 14 145 581 1,060 628 77 1 2,506 8.2 20 and under 400 21-30 1,788 31-40 2,605 41-50 2,155 51-60 2,250 61-70 1,800 71-80 477 81-90 7 Total 11,482 5 27 75 160 122 21 FEMALES 0.0 0.3 1.0 3.5 7.1 6.8 4.4 410 3.6 7 61 113 121 84 18 404 0.0 0.4 2.3 5.2 5.4 4.7 3.8 3.5 12 88 188 206 39 814 0.0 0.7 3.3 8.7 12.5 11.5 8.2 0.0 7.1 Source: The Insurance Year Book, 1910-1912, Department of Agriculture and Com- merce, Japan. Table 121 Mortality Experience of Foreign Life Insurance Companies of Japan Mortality from Cancer by Organs and Parts according to Age, Males, 1912 Ages 20 and under . 21-30 31-40... 41-50 51-60 61-70 Total . Deaths from All Causes 5 13 62 103 79 28 290 MALES Cancer of Stomach Per Cent. Deaths of All Causes 1.9 10.1 10.7 4.5 13 Cancer of Other Organs Per Cent. Deaths of All Causes 4 11 5 20 3.9 13.9 17.9 6.9 Cancer of All Organs Per Cent, of All Causes Deaths 6 19 33 5.8 24.0 28.6 11.4 Source: The Insurance Year Book, 1912, Department of Agriculture and Commerce, Japan. Note : There were no cases of cancer in the female experience. 401 APPENDIX E Cancer Mortality According to Latitude, Size or Cities, and Specified Organs and Parts Throughout the World Table Page 1 Mortality from Cancer in Large Cities, according to Latitude, 1908-1912 403 2 Mortality from Cancer in Large Cities of the Eastern and Western Hemi- spheres, according to Latitude, 1908-1912 407 3 Mortality from Cancer in Cities, according to Size, 1908-1912 410 4 Comparative Mortality from Cancer, by Organs and Parts, in Thirteen Princi- pal Countries of the World 413 402 APPENDIX E Table 1 Mortality from Cancer in Large Cities, according to Latitude 1908-1912 MORE NORTHERLY THAN 50° N. LATITUDE City Bergen Petrograd Kristiania Stockholm Goteborg Aberdeen Edinburgh .... Glasgow Moscow Copenhagen. . . Kbnigsberg. . . . Belfast Leeds Sheffield Hamburg Liverpool Manchester Dublin Bremen Berlin Birmingham. . . Amsterdam The Hague. . . . Rotterdam .... London Bristol Essen Leipzig Antwerp Dresden Cologne Brussels Liege Lille Frankfurt a/M. Total Deaths Rate per Latitude Population Total from 100,000 North 1912 Population Cancer Population 60°24' 77,404 383,100 376 98.1 59°57' 1.990,874 9,815,760 8,400 85.6 59°55' 243,967 1,205,625 1,229 101.9 59°21' 346,848 1,712,593 2,047 119.5 57°41' 172,006 821,817 759 91.2 57° 8' 164,932 814,268 941 115.6 55°57' 321,119 1,602,543 1,918 119.7 55°53' 785,600 3,918,239 4,190 106.9 55°45' 1,617,733 7,050,000 5,805 82.3 55°41' 570,000 2,744,628 4,427 161.3 54°43' 255,684 1,226,145 1,487 121.3 54°36' 390,724 1,915,845 1,612 84.1 53°46' 447,746 2,221,718 2,308 103.9 53°37' 466,408 2,261,241 1.894 83.8 53°24' 1,063,201 5,006,244 5,276 105.4 53°24' 752,021 3,716,551 3,592 96.6 53°23' 724,168 3,460,469 3,321 96.0 53°23' 306,218 1,516,918 1,701 112.1 53° 5' 316,000 1,484,152 1,546 104.2 52°30' 2,100,000 10,361,160 13,831 133.5 52°30' 850,947 2,951,231 2,592 87.8 52°22' 588,000 2,874,663 3,355 116.7 52° 4' 294,540 1,375,718 1,490 108.3 51°55' 445,137 2,137,458 1,980 92.6 51°31' 4,531,572 22,671,154 25,322 111.7 51°27' 359,400 1,784,270 1,792 100.4 51°27' 305,024 1,414,452 856 60.5 51°20' 605,755 2,848,078 2,817 98.9 51°13' 322,275 1,554,689 1,376 88.5 51° 2' 557,400 2,727,750 3,594 131.8 50°52' 544,329 2,546,035 2.404 94.4 50°51' 646,400 891.295 939 105.4 50°38' 167,851 837,517 878 104.8 50°37' 220,243 1,076,849 1,469 136.4 50° 6' 428,500 1,982,500 1,850 93.3 23,980,086 112,912,675 119,374 105.7 403 APPENDIX E Table 1 (continued) Mortality from Cancer in Large Cities, according to Latitude 1908-1912 LATITUDE 50° N.-40° N. Deaths Rate per Latitude Population Total from 100,000 City North 1912 Population Cancer Population 49°56' 49°29' 49°27' 159,256 136,905 345,416 715,250 677,065 1,649,630 362 917 1,721 50.6 Le Havre 135.4 Nuremberg 104.3 Paris 48°50' 2,872,400 14,111,481 15,638 110.8 Nancy 48°40' 121,688 591,050 705 119.3 Vienna 48°14' 2,077,295 10,064,070 12,971 128.9 Munich 48° 9' 615,000 2,951,000 4,936 • 167.3 Seattle 47°36' 268,500 1,185,970 662 55.8 Basel 47°34' 135,632 657,827 752 114.3 Budapest 47°29' 905,244 4,337,060 4,450 102.6 Zurich 47°23' 199,000 945,026 1,053 111.4 Beme 46°57' 86,900 417,323 446 106.9 Quebec 46°48' 79,300 379,013 209 55.1 Geneva 46°12' 130,000 621,646 766 123.2 Lyon 45°42' 534,132 2,618,980 3,908 149.2 Montreal. 45°30' 484,400 2,185,680 1,429 65.4 Milan 45°28' 609,974 2,942,130 3,562 121.1 St. John 45°14' 42,691 436,251 211,655 2,089,805 173 2,341 81.7 Turin 45° 4' 112.0 Minneapolis 44°58' 321,146 1,507,040 1,052 69.8 St. Paul 44°52' 221,832 263,624 1,073,718 1,042,820 802 1,184 74.7 Bordeaux 44°50' 113.5 44°24' 275,972 1,342,350 1,393 103.8 Florence 43°45' 235,587 1,150,665 1,861 161.7 43°43' 144,682 710,345 710 99.8 Toronto 43°40' 414,000 1,819,052 1,313 72.2 43° 8' 232,741 1,090,742 996 91.3 Milwaukee 43° 3' 398,219 1,869,282 1,292 69.1 Buffalo 42°53' 442,567 2,118,575 1,879 88.7 Boston 42°22' 715,711 3,352,926 3,545 105.7 42°20' 515,156 2,328,827 1,528 65.6 Springfield, Mass 42° 6' 94,300 444,630 407 91.5 41°54' 550,057 2,670,945 2,679 100.3 Chicago 41°53' 2,282,623 10,926,412 8,618 78.9 Providence 41°50' 234,602 1,121,628 1,098 97.9 Hartford 41°46' 102,727 494,572 492 99.5 41°30' 596,443 2,803,315 1,960 69.9 New Haven 41°19' 138,721 128,404 668,025 620,478 616 538 92.2 41°16' 86.7 Constantinople 41° 0' 1,200,000 5,750,000 2,001 34.8 40°51' 689,480 3,332,910 2,168 65.0 Newark 40°45' 373,141 1,737,345 1,313 75.6 40°44' 72,268 351,621 283 80.5 Jersey City 40°43' 281,811 5,032,821 1,338,895 23,834,415 833 18,385 62.2 40°43' 77.1 Pittsburgh 40°26' 550,385 2,669,525 1,773 66.4 Madrid 40°24' 578,000 2,825,985 2,673 94.6 Columbus 40° 0' 192,701 907,553 823 121,216 90.7 Total 27,519,705 131,256,257 92.4 404 APPENDIX E Table 1 (continued) Mortality from Cancer in Large Cities, according to Latitude 1908-1912 LATITUDE 40° N.-30° N. Latitude Population Total City North 1912 Population Philadelphia 39°57' 1,600,072 7,745,040 Dayton 39°44' 122,825 582,882 Denver 39°41' 229,287 1,066,905 Indianapolis 39°40' 246,546 1,168,247 Baltimore 39°17' 568,391 2,792,425 Kansas City, Mo 39° 8' 265,306 1,241,903 Washington 38°53' 341,541 1,655,346 St Louis 38°38' 709,387 3,435,143 Lo'uis\dlle 38°12' 227,766 1,119,637 Cincinnati 38° 8' 371,129 1,817,955 Palermo 38° 7' 344,227 1,689,745 Athens 37°58' 188,130 816,750 San Francisco 37°48' 431,738 2,084,560 Richmond 37°32' 136,144 638,140 Nash\'ille 36° 9' 116,264 551,820 Gibraltar 36° 7' 19,017 97,823 Tokio ... 35°39' 1,860,000 8,132,879 Memphis 35° 8' 136,861 655,522 Kyoto 35° 1' 490,000 2,216,496 Osaka .... 34°44' 1,260,000 6,014,365 Los Angeles 34° 5' 362,541 1,595,988 Augusta 33°33' 41,360 205,200 Charleston 32°46' 59,437 294,162 Savannah, Ga 32° 5' 67,228 325,320 Total 10,195,197 47,944,253 LATITUDE 30° N.-10° N. New Orleans 29°58' 349,471 1,695,376 Havana 23° 9' 353,509 1,644,513 Calcutta 22°34' 900,894 4,456,200 Hongkong 22°18' 368,420 1,777,706 Mexico City 19°26' 491,500 2,355,330 Manila 14°35' 241,653 1,172,043 Caracas 10°31' 75,000 375,000 Total 2,780,447 13,476,168 LATITUDE 10° N.-10° S. Paramaribo 5°49' 35,000 Bogota 4°35' 121,257 Singapore 1°17' 323,373 Guayaquil S. 2°11' 80,000 Total 559,630 2,583,495 Deaths from Cancer Rate per 100,000 Population 6,610 525 85.3 90.1 887 83.1 947 81.1 2,500 981 89.5 79.0 1,455 2,815 764 87.9 81.9 68.2 1,680 892 92.4 52.8 543 66.5 2,287 518 109.7 81.2 377 68.3 81 82.8 5,918 333 72.8 50.8 1,968 3,281 1,610 124 88.8 54.6 100.9 60.4 173 58.8 182 55.9 37,451 5,696 78.1 1,440 84.9 1,689 102.7 522 11.7 157 8.8 1,165 49.5 330 28.2 393 104.8 42.3 174,775 167 95.6 607,465 545 89.7 1,521,255 177 11.6 280,000 167 59.6 1,056 40.9 405 APPENDIX E Table 1 (concluded) Mortality from Cancer in Large Cities, according to Latitude 1908-1912 LATITUDE, 10°S.-30°S. Latitude Population City South 1912 Bahia 13° 0' 300,000 La Paz 16°30' 86,926 Bello Horizonte 20° 0' 39,845 Rio de Janeiro 22°54' 710,600 Sao Paulo 23°38' 400,000 Johannesburg 26°26' 249,000 Santiago del Estero 27°48' 20,580 Total 1,806,951 LATITUDE, 30°S.-40°S. Pelotas 31°50' 38,207 Rosario de Santa Fe 33° 0' 225,600 Sydney 33°52' 675,800 Buenos Aires 34°36' 1,383,663 Montevideo 34°54' 355,017 Total 2,678,287 12,297,218 Deaths Rale per Total from 100,000 Population Cancer Population 1,413,800 328 23.2 316,090 69 21.8 112,280 41 36.5 3,357,032 1,427 42.5 1,694,000 769 45.4 1,076,862 370 34.4 96,080 36 37.5 8,066,144 3,040 37.7 181,201 147 81.1 937,604 684 73.0 3,114,640 2,805 90.1 6,406,275 5,475 85.5 1,657,498 1,937 116.9 11,048 406 APPENDIX E Table 2 Mortality from Cancer in Large Cities of the Eastern and Western Hemispheres, according to Latitude 1908-1912 LATITUDE, 50°N.-40°N., EASTERN HEMISPHERE Latitude City North Le Havre 49°29' Nuremberg 49°27' Paris 48°50' Nancy 48°40' Vienna 48°14' Munich 48° 9' Basel 47°34' Budapest 47°29' Zurich 47°23' Berne 46°57' Geneva 46°12' Lyon 45°42' Milan 45°28' Turin 45° 4' Bordeaux 44°50' Genoa 44°24' Florence 43°45' Nice 43°43' Rome 41°54' Constantinople 41° 0' Naples 40°51' Madrid 40°24' Total LATITUDE, 50° N.-40° Winnipeg 49°56' Seattle 47°36' Quebec 46°48' Montreal 4o°30' St. John 45°14| Minneapolis 44°o8 St. Paul 44°52' Toronto 43W Rochester 43 8 Milwaukee 43° 3' Buffalo 42°53' Boston 42°22' Detroit 42°20' SpringBeld, Mass 42° 6' Chicago 41°53'^ Providence 41°50' Hartford 41°46' Cleveland 41°30' New Haven 41°19' Omaha 41°16' Newark 40°45' Hoboken 40°44^ Jersey City 40 43 Greater New York 40°43' Pittsburgh 40°26' Columbus 40° 0' Total Population 191^2 136,905 345,416 2,872,400 121,688 2,077,295 615,000 135,632 905,244 199,000 86,900 130,000 534,132 609,974 436,251 263,624 275,972 235,587 144,682 550,057 1,200,000 689,480 578,000 13.143,239 N., WESTERN 159,256 268,500 79,300 484,400 42,691 321,146 221,832 414,000 232,741 398,219 442,567 715,711 515,156 94,300 2,282,623 234,602 102,727 596,443 138,721 128,404 373,141 72,268 281,811 5,032,821 550,385 192,701 Total Population 677,065 1,649,630 14,111,481 591,050 10,064,070 2,951,000 657,827 4,337,060 945,026 417,323 621,646 2,618,980 2,942,130 2,089,805 1,042,820 1,342,350 1,150,665 710,345 2,670,945 5,750,000 3,332,910 2,825,985 63,500,113 HEMISPHERE 715,250 1,185,970 379,013 2,185,680 211,655 1,507,040 1,073,718 1,819,052 1,090,742 1,869,282 2,118,575 3,352,926 2,328,827 444,630 10,926,412 1,121,628 494,572 2,803,315 668,025 620,478 1,737,345 351,621 1,338,895 23,834,415 2,669,525 907,553 Deaths from Cancer 917 1,721 15,638 705 12,971 4,936 752 4,450 1,053 446 766 3,908 3,562 2,341 1,184 1,393 1,861 710 2,679 2,001 2,168 2,673 68,835 362 662 209 1,429 173 1,052 802 1,313 996 1,292 1,879 3,545 1,528 407 8,618 1,098 492 1,960 616 538 1,313 283 833 18,385 1,773 823 Rate per 100,000 Population 135.4 104.3 110.8 119.3 128.9 167.3 114.3 102.6 111.4 106.9 123.2 149.2 121.1 112.0 113.5 103.8 161.7 99.8 100.3 34.8 65.0 94.6 108.4 50.6 55.8 55.1 65.4 81.7 69.8 74.7 72.2 91.3 69.1 88.7 105.7 65.6 91.5 78.9 97.9 99.5 69.9 92.2 86.7 75.6 80.5 62.2 77.1 66.4 90.7 14,376,466 67,756,144 52,381 77.3 407 APPENDIX E Table 2 (continued) Mortality from Cancer in Large Cities of the Eastern and Western Hemispheres, according to Latitude 1908-1912 LATITUDE, 40°N.-30°N., EASTERN HEMISPHERE City Palermo. . Athens Gibraltar. . Tokio Kyoto .... Osaka. . . . Deaths Rate per Latitude Population Total from 100,000 North 1912 Population Cancer Population 38° 7' 344,227 1,689,745 892 52.8 37°58' 188,130 816,750 543 66.5 36° 7' 19,017 97,823 81 82.8 35°39' 1,860,000 8,132,879 5,918 72.8 35° 1' 490,000 2,216,496 1,968 88.8 34°44' 1,260,000 6,014,365 3,281 54.6 Total. 4,161,374 18,968,058 12,683 LATITUDE, 40'='N,-30°N., WESTERN HEMISPHERE Philadelphia Dayton Denver Indianapolis Baltimore Kansas City, Mo. Washington St. Louis Louisville Cincinnati San Francisco . . . . Richmond Nashville Memphis Los Angeles Augusta Charleston Savannah, Ga Total. Calcutta. . Hongkong. Manila Total. New Orleans. Havana Mexico City. Caracas 6,033,823 28,976,195 LATITUDE, 30°N.-10°N., EASTERN HEMISPHERE 22°34' 22°18' 14°35' 900,894 368,420 241,653 4,456,200 1,777,706 1,172,043 LATITUDE, 30°N.-10° 29°58' 23° 9' 19°26' 10°31' 1,510,967 7,405,949 WESTERN HEMISPHERE 349,471 353,509 491,500 75,000 1,695,376 1,644,513 2,355,330 375,000 Total. 1,269,480 6,070,219 24,768 157 330 1,009 1,440 1,689 1,165 393 4,087 66.9 39°57' 1,600,072 7,745,040 6,610 85.3 39°44 122,825 582,882 525 90.1 39°41' 229,287 1,066,905 887 83.1 39°40' 246,546 1,168,247 947 81.1 39°17 568,391 2,792,425 2,500 89.5 39° 8 265,306 1,241,903 981 79.0 38°53 341,541 1,655,346 1,455 87.9 38°38 709,387 3,435,143 2,815 81.9 38°12' 227,766 1,119,637 764 68.2 38° 8' 371,129 1,817,955 1,680 92.4 37°48' 431,738 2,084,560 2,287 109.7 37^32' 136,144 638,140 518 81.2 36° 9' 116,264 551,820 377 68.3 35° 8' 136,861 655,522 333 50.8 34° 5 362,541 1,595,988 1,610 100.9 33°33' 41,360 205,200 124 60.4 32°46' 59,437 294,162 173 58.8 32° 5' 67,228 325,320 182 55.9 85.5 11.7 8.8 28.2 13.6 84.9 102.7 49.5 104.8 77.2 408 APPENDIX E Table 2 (concluded) Mortality from Cancer in Large Cities of the Eastern and Western Hemispheres, according to Latitude 1908-1912 Deaths Rate per from 100,000 Cancer Population 177 11.6 167 545 167 879 370 2,670 2,805 95.6 89.7 59.6 82.7 34.4 LATITUDE, lO-N.-lO-S., EASTERN HEMISPHERE Latitude Population Total City North 1912 Population Singapore 1°17' 323,373 1,521,255 LATITUDE, 10°N.-10°S., WESTERN HEMISPHERE Paramaribo 5°49' 35,000 174,775 Bogota 4°35' 121,257 607,465 Guayaquil S. 2°11' 80,000 280,000 Total 236,257 1,062,240 LATITUDE, 10° 8.-30° S., EASTERN HEMISPHERE Johannesburg 26°26' 249,000 1,076,862 LATITUDE, 10°S.-30°S., WESTERN HEMISPHERE Bahia 13° 0' 300,000 1,413,800 La Paz 16°30' 86,926 316,090 Bello Horizonte 20° 0' 39,845 112,280 Rio de Janeiro 22°54' 710,600 3,357,032 Sao Paulo 23°38' 400,000 1,694,000 Santiago del Estero 27°48' 20,580 96,080 Total 1,557,951 6,989,282 LATITUDE, 30°S.-40°S., EASTERN HEMISPHERE Sydney 33°52' 675,800 3,114,640 LATITUDE, 30°S.-40°S., WESTERN HEMISPHERE Pelotas 31°50' 38,207 181,201 Rosario de Santa Fe 33° 0' 225,600 937,604 Buenos Aires 34°36' 1,383,663 6,406,275 Montevideo 34°54' 355,017 1,657,498 Total 2,002,487 9,182,578 328 23.2 69 21.8 41 36.5 1,427 42.5 769 45.4 36 37.5 38.2 90.1 147 81.1 684 73.0 5,475 85.5 1,937 116.9 8,243 89.8 409 APPENDIX E Table 3 Mortality from Cancer in Cities, according to Size, 1908-1912 Rate per No. of Population Total Deaths from 100,000 Cities 1912 Population Cancer Population 14 1,000,000 and over 30,872,254 147,889,255 137,531 93.0 26 500,000- 1,000,000 17,049,274 78,667,982 74,482 94.7 41 250,000- 500,000 14,858,442 70,138,157 58,804 83.8 27 125,000- 250,000 5,140,049 24,367,754 21,946 90.1 22 Less than 125,000 1,600,284 7,473,062 6,118 81.9 130 69,520,303 328,536,210 298,881 91.0 Cities with 1,000,000 Population and Over 1 Greater New York 5,032,821 23,834,415 18,385 77.1 2 London 4,531,572 22,671,154 25,322 111.7 3 Paris 2,872,400 14,111,481 15,638 110.8 4 Chicago 2,282,623 10,926,412 8,618 78.9 5 BerUn 2,100,000 10,361,160 13,831 133.5 6 Vienna 2,077,295 10,064,070 12,971 128.9 7 Petrograd 1,990,874 9,815,760 8,400 85.6 8 Tokio 1,860,000 8,132,879 5,918 72.8 9 Moscow 1,617,733 7,050,000 5,805 82.3 10 Philadelphia 1,600,072 7,745,040 6,610 85.3 11 Buenos Aires 1,383,663 6,406,275 5,475 85.5 12 Osaka 1,260,000 6,014,365 3,281 54.6 13 Constantinople 1,200,000 5,750,000 2,001 34.8 14 Hamburg 1,063,201 5,006,244 5,276 105.4 Total 30,872,254 147,889,255 137,531 93.0 Cities with 500,000 to 1,000,000 Population 1 Budapest 905,244 4,337,060 4,450 102.6 2 Calcutta 900,894 4,456,200 522 11.7 3 Glasgow 785,600 3,918,239 4,190 106.9 4 Birmingham 850,947 2,951,231 2,592 87.8 5 Liverpool 752,021 3,716,551 3,592 96.6 6 Manchester 724,168 3,460,469 3,321 96.0 7 Boston 715,711 3,352,926 3,545 105.7 8 Rio de Janeiro 710,600 3,357,032 1,427 42.5 9 St. Louis 709,387 3,435,143 2,815 81.9 10 Naples 689,480 3,332,910 2,168 65.0 11 Sydney 675,800 3,114,640 2,805 90.1 12 Brussels 646,400 891,295 939 105.4 13 Munich 615,000 2,951,000 4,936 167.3 14 Milan 609,974 2.942,130 3,562 121.1 15 Leipzig 605,755 2,848,078 2,817 98.9 16 Cleveland 596,443 2,803,315 1,960 69.9 17 Amsterdam 588,000 2,874,663 3,355 116.7 18 Madrid 578,000 2,825,985 2,673 94.6 19 Copenhagen 570,000 2,744,628 4,427 161.3 20 Baltimore 568,391 2,792,425 2,500 89.5 21 Dresden 557,400 2,727,750 3,594 131.8 22 Pittsburgh 550,385 2,669,525 1,773 66.4 23 Rome 550,057 2,670,945 2,679 100.3 24 Cologne 544,329 2,546,035 2,404 94.4 25 Lyon 534,132 2,618,980 3,908 149.2 20 Detroit 515,156 2,328,827 1,528 65.6 Total 17,049,274 78,667,982 74,482 94.7 410 APPENDIX E Table 3 (continued) Mortality from Cancer in Cities, according to Size, 1908-1912 Cities with 250,000 to 500,000 Population Population Total City 1912 Population 1 Mexico City 491,500 2,355,330 2 Kyoto 490,000 2,216,496 3 Montreal 484,400 2,185,680 4 Sheffield 466,408 2,261,241 5 Leeds 447,746 2,221,718 Rotterdam 445,137 2,137,458 7 Buffalo 442,567 2,118,575 8 Turin 436,251 2,089,805 9 San Francisco 431,738 2,084,560 10 Frankfurt a/M 428,500 1,982,500 11 Toronto 414,000 1,819,052 12 Sao Paulo 400,000 1,694,000 13 Milwaukee 398,219 1,869,282 14 Belfast 390,724 1,915,845 15 Newark 373,141 1,737,345 16 Cincinnati 371,129 1,817,955 17 Hongkong 368,420 1,777,706 18 Los Angeles 362,541 1,595,988 19 Bristol 359,400 1,784,270 20 Monte\adeo 355,017 1,657,498 21 Havana 353,509 1,644,513 22 New Orleans 349,471 1,695,376 23 Stockholm 346,848 1,712,593 24 Nuremberg 345,416 1,649,630 25 Palermo 344,227 1,689,745 26 Washington 341,541 1,655,346 27 Singapore 323,373 1,521,255 28 Antwerp 322,275 1,554,689 29 Minneapolis 321,146 1,507,040 30 Edinburgh 321,119 1,602,543 31 Bremen 316,000 1,484,152 32 Dublin 306,218 1,516,918 33 Essen 305,024 1,414,452 34 Bahia 300,000 1,413,800 35 The Hague 294,540 1,375,718 36 Jersey City 281,811 1,338,895 37 Genoa 275,972 1,342,350 38 Seattle 268,500 1,185,970 39 Kansas City, Mo 265,306 1,241,903 40 Bordeaux 263,624 1,042,820 41 Konigsberg 255,684 1,226,145 Total 14,858,442 70,138,157 Rate per Deaths from 100,000 Cancer Population 1,165 49.5 1,968 88.8 1,429 65.4 1,894 83.8 2,308 103.9 1,980 92.6 1,879 88.7 2,341 112.0 2,287 109.7 1,850 93.3 1,313 72.2 769 45.4 1,292 69.1 1,612 84.1 1,313 75.6 1,680 92.4 157 8.8 1,610 100.9 1,792 100.4 1,937 116.9 1,689 102.7 1,440 84.9 2,047 119.5 1,721 104.3 892 52.8 1,455 87.9 177 11.6 1,376 88.5 1,052 69.8 1,918 119.7 1,546 104.2 1,701 112.1 856 60.5 328 23.2 1,490 108.3 833 62.2 1,393 103.8 662 55.8 981 79.0 1,184 113.5 1,487 121.3 58,804 83.8 411 APPENDIX E Table 3 (concluded) Mortality from Cancer in Cities, according to Size, 1908-1912 Cities with 125,000 to 250,000 Population Population Total Deaths from City 1912 Population Cancer 1 Johannesburg 249,000 1,076,862 370 2 Indianapolis 246,546 1,168,247 947 3 Kristiania 243,967 1,205,625 1,229 4 Manila 241,653 1,172,043 330 5 Florence 235,587 1,150,665 1,861 6 Pro^-idence 234,602 1,121,628 1,098 7 Rochester 232,741 1,090,742 996 8 Denver 229,287 1,066,905 887 9 Loms\alle 227,766 1,119,637 764 10 Rosario de Santa Fe 225,600 937,604 684 11 St. Paul 221,832 1,073,718 802 12 LQle 220,243 1,076,849 1,469 13 Zurich 199,000 945,026 1,053 14 Columbus 192,701 907,553 823 15 Athens 188,130 816,750 543 16 Goteborg 172,006 821,817 759 17 Liege 167,851 837,517 878 18 Aberdeen 164,932 814,268 941 19 Winnipeg 159,256. 715,250 362 20 Nice 144,682 710,345 710 21 New Haven 138,721 668,025 616 22 Le Ha\Te 136,905 677,065 917 23 Memphis 136,861 655,522 333 24 Richmond 136,144 638,140 518 25 Basel 135,632 657,827 752 26 Geneva 130,000 621,646 766 27 Omaha 128,404 620,478 538 Total 5,140,049 24,367,754 21,946 Cities with Less Than 125,000 Population 1 Dayton 122,825 582,882 525 2 Nancy 121,688 591,050 705 3 Bogota 121,257 607,465 545 4 Nash\alle 116,264 551,820 377 5 Hartford 102,727 494,572 492 6 Springfield, Mass 94,300 444,630 407 7 La Paz 86,926 316,090 69 8 Bern 86,900 417,323 446 9 Guayaquil 80,000 280,000 167 10 Quebec 79,300 379,013 209 11 Bergen 77,464 383,100 376 12 Caracas 75,000 375,000 393 13 Hoboken 72,268 351,621 283 14 Savannah 67,228 325,320 182 15 Charleston 59,437 294,162 173 16 St. John 42,691 211,655 173 17 Augusta, Ga 41,360 205,200 124 18 BelloHorizonte 39,845 112,280 41 19 Pelotas 38,207 181,201 147 20 Paramaribo 35,000 174,775 167 21 Santiago del Estero 20,580 96,080 36 22 Gibraltar 19,017 97.823 81 Total 1,600,284 7,473,062 6,118 Rate per 100,000 Population 34.4 81.1 101.9 28.2 161.7 97.9 91.3 83.1 68.2 73.0 74.7 136.4 111.4 90.7 66.5 91.2 104.8 115.6 50.6 99.8 92.2 135.4 50.8 81.2 114.3 123.2 86.7 90.1 90.1 119.3 89.7 68.3 99.5 91.5 21.8 106.9 59.6 55.1 98.1 104.8 80.5 55.9 58.8 81.7 60.4 36.5 81.1 95.6 37.5 82.8 81.9 412 APPENDIX E Table 4 Comparative Mortality from Cancer, by Organs and Parts in Thirteen Principal Countries of the World Australian Commonwealth, 1908-1912 Deaths Rate per from 100,000 Cancer Population Stomach and Liver 6,024 27.4 Skin 503 2.3 Rate per 100,000 Female Population Female generative organs 1,635 15.6 Female breast 1.117 10.6 Total population 21,997,568 Female population 10,573,554 General cancer death rate 73.2 Bavaria, 1905-1910 Deaths Rate per from 100,000 Cancer Population Stomach and liver 23,911 59.4 Skin 311 0.8 Rate per 100,000 Female Population Female generative organs 4,434 21.6 Female breast l,S1\ 9.1 Total population 40,234,987 Female population 20,507,907 General cancer death rate 109.4 Cuba, 1908-1912 Deaths Rate per from 100,000 Cancer Population Stomach and liver 1,383 12.7 Skin 215 2.0 Rate per 100,000 Female Population Female generative organs 973 18.9 Female breast 232 4.5 Total population 10,892,077 Female population 5,157,276 General cancer death rate 44.6 413 APPENDIX E Table 4 (continued) Comparative Mortality from Cancer, by Organs and Parts in Thirteen Principal Countries of the World England and Wales, 1906-1910 Deaths Rate per from 100,000 Cancer Population Stomach and liver 55,105 31.4 Skin 3,731 2.1 Rate per 100,000 Female Population Female generative organs 21,908 24.2 Female breast 16,185 17.9 Total population 175,333,013 Female population 90,535,741 General cancer death rate 94.0 Holland, 1906-1910 Deaths Rate per from 100,000 Cancer Population Stomach and liver 17,878 62.2 Skin . 411 1.4 Rate per 100,000 Female Population Female generative organs 1,919 13.2 Female breast 1,390 9.6 Total population 28,725,355 Female population 14,506,305 General cancer death rate 103.5 Ireland, 1906-1910 Deaths Rate per from 100,000 Cancer Population Stomach and liver 6,795 31.0 Skin 589 2.7 Rate per 100,000 Female Population Female generative organs 1,415 12.8 Female breast 1,545 14.0 Total population 21,942,708 Female population 11,012,089 General cancer death rate 78.8 414 APPENDIX E Table 4 (continued) Comparative Mortality from Cancer, by Organs and Parts in Thirteen Principal Countries of the World Italy, 1906-1910 Deaths Rate per from 100,000 Cancer Population Stomach and liver 44,330 26.2 Skin Rate per 100,000 Female Population Female generative organs 13,741 16.0 Female breast 5,019 5.8 Total population 169,081,524 Female population 85,896,061 General cancer death rate 63.6 Japan, 1909-1910 Deaths Rate per from 100,000 Cancer Population Stomach and liver 39,861 40.0 Skin 734 0.7 Rate per 100,000 Female Population Female generative organs 10,322 20.9 Female breast 878 1.8 Total population 99,728,840 Female population 49,505,396 General cancer death rate 65.5 Norway, 1906-1910 Deaths Rate per from 100,000 Cancer Population Stomach and liver 7,130 61.4 Skin Rate per 100,000 Female Population Female generative organs 692 11.5 Female breast 440 7.3 Total population 11,606,600 Female population 5,993,116 General cancer death rate 96.6 415 APPENDIX E Table 4 (continued) Comparative Mortality from Cancer, by Organs and Parts in Thirteen Principal Countries of the World Scotland, 1906-1910 Deaths Rate per from 100,000 Cancer Population Stomach and liver 8,417 36.0 Skin 396 1.7 Rate per 100,000 Female Population Female generative organs 2,479 20.6 Female breast 1,856 15.4 Total population 23,394,061 Female population 12,047,942 General cancer death rate 99.7 Switzerland, 1906-1910 Deaths Rate per from 100,000 Cancer Population Stomach and liver 12,838 70.4 Skin 344 1.9 Rate per 100,000 Female Population Female generative organs 1,995 21.4 Female breast 1,264 13.6 Total population 18,237,395 Female population 9,301,072 General cancer death rate 125.9 Uruguay, 1906-1910 Deaths Rate per from 100,000 Cancer Population Stomach and liver 1,880 35.6 Skin 57 1.1 Rate per 100,000 Female Population Female generative organs ■. . . . 317 12.2 Female breast 96 3.7 Total population 5,277,942 Female population 2,592,524 General cancer death rate 66.0 416 APPENDIX K Table 4 (concluded) Comparative Mortality from Cancer, by Organs and Parts in Thirteen Principal Countries of the World United States Registration Area, 1906-1910 Deaths Rate per from 100,000 Cancer Population Stomach and liver 66,976 28.3 Skin 6,338 2.7 Rate per 100,000 Female Population Female generative organs 25,589 22.1 Female breast 15.349 13.3 Total population 236,504,736 Female population 115,779,973 General cancer death rate 72.6 417 APPENDIX F PART I Cancer Mortality Statistics of the United States Registration Area Table Page 1 Estimated Mortality from Cancer, Continental United States, 1900-1913 422 2 Mortality from Cancer, United States Registration Area, 1900-1913 422 3 Mortality from Cancer, United States Registration States, 1900-1913. . . 422 4 Mortality from Cancer, United States Registration Cities, 1900-1913 422 5 Mortality from Cancer, California, 1906-1913 422 6 Mortality from Cancer, Colorado, 1906-1913 422 7 Mortality from Cancer, Connecticut, 1900-1913 423 8 Mortality from Cancer, Indiana, 1900-1913 423 9 Mortality from Cancer, Kentucky, 1911-1913 423 10 Mortality from Cancer, Maine, 1900-1913 423 11 Mortality from Cancer, Maryland, 1906-1913 423 12 Mortality from Cancer, Massachusetts, 1900-1913 423 13 Mortality frotai Cancer, Michigan, 1900-1913 424 14 Mortality from Cancer, Minnesota, 1910-1913 424 15 Mortality from Cancer, Missouri, 1911-1913 424 16 Mortality from Cancer, Montana, 1910-1913 424 17 Mortality from Cancer, New Hampshire, 1900-1913 424 18 Mortality from Cancer, New Jersey, 1900-1913 425 19 Mortality from Cancer, New York, 1900-1913 425 20 Mortality from Cancer, North Carolina, 1910-1913 425 21 Mortality from Cancer, Ohio, 1909-1913 425 22 Mortality from Cancer, Pennsylvania, 1906-1913 425 23 Mortality from Cancer, Rhode Island, 1900-1913 426 24 Mortality from Cancer, South Dakota, 1906-1909 426 418 APPENDIX F {PART I) Table Page 25 Mortality from Cancer, Utah, 1910-1913 426 26 Mortality from Cancer, Vermont, 1900-1913 426 27 Mortality from Cancer, Washington, 1908-1913 426 28 Mortality from Cancer, Wisconsin, 1908-1913 426 29 Estimated Mortality from Malignant and Benign Tumors, Continental United States, 1900-1913 427 30 Estimated Mortality from Benign Tumors, Continental United States, 1900- 1913 427 31 Mortality from Cancer, United States Registration Area, Males, 1900-1913 427 32 Mortality from Cancer, United States Registration Area, Females, 1900-1913 . . . 427 33 Mortality from Benign Tumors, United States Registration Area, 1900-1913 .... 428 34 Mortality from Benign Tumors, United States Registration Area, Males, 1900- 1913 428 35 Mortality from Benign Tumors, United States Registration Area, Females, 1900-1913 429 36 Mortality from Ulcer of Stomach, by Sex, United States Registration Area, 1900-1913 429 37 Mortality from Biliary Calculi, by Sex, United States Registration Area, 1900- 1913 430 38 Mortality from Calculi of the Urinary Tract, by Sex, United States Registra- tion Area, 1900-1913 430 39 Mortality from Cancer, by Race, United States Registration Area, 1910-1912. . . 431 40 Mortality from Cancer, Urban and Rural, United States Registration States, 1900-1913 431 41 Mortality from Cancer of the Buccal Cavity, by Sex, United States Registra- tion Area, 1900-1913 432 42 Mortality from Cancer of the Stomach and Liver, by Sex, United States Registration Area, 1900-1913 432 43 Mortality from Cancer of the Peritoneum, Intestines and Rectum, by Sex, United States Registration Area, 1900-1913 433 44 Mortality from Cancer of the Female Generative Organs and Female Breast, United States Registration Area, 1900-1913 433 45 Mortality from Cancer of the Skin, by Sex, United States Registration Area, 1900-1913 434 46 Mortality from Cancer of Other or Not Specified Organs and Parts, by Sex, United States Registration Area, 1900-1913 434 47 Estimated Mortality from Cancer, by Organs and Parts, Continental United States, 1900-1913 435 48 Population Statistics, by Age and Sex, United States Registration Area, 1903- 1912 435 419 APPENDIX F {PART I) Table Page 49 Mortality from Cancer, by Age and Sex, United States Registration Area, 1903- •1912 436 50 Mortality from Cancer of the Buccal Cavity, by Age and Sex, United States Registration Area, 1903-1912 436 51 Mortality from Cancer of the Stomach and Liver, by Age and Sex, United States Registration Area, 1903-1912 437 52 Mortality from Cancer of the Peritoneum, Intestines and Rectum, by Age and Sex, United States Registration Area, 1903-1912 437 53 Mortality from Cancer of the Female Generative Organs and Female Breast, by Age, United States Registration Area, 1903-1912 438 54 Mortality from Cancer of the Skin, by Age and Sex, United States Registration Area, 1903-1912 438 55 Mortality from Cancer of Other or Not Specified Organs and Parts, by Age and Sex, United States Registration Area, 1903-1912 439 56 Mortality from Cancer, Urban and Rural, by Organs and Parts, United States Registration States, 1908-1912 439 57 Proportion of Mortality from Cancer to All Causes, by Age and Sex, United States Registration Area, 1908-1912 440 58 Mortality from Cancer and Other Important Causes of Death, by Age and Sex, United States Registration Area, 1908-1912 440 59 Mortality from Cancer, by Months, New York, Massachusetts, New Hampshire and Connecticut, 1902-1911 441 60 Comparative Cancer Death Rate, by Age and Sex, United States Registration Area, 1901-1911 442 61 Mortality from Cancer, by Age, Males, United States Registration Area, 1903- 1907 Compared with 1908-1912 443 62 Mortality from Cancer, by Age, Females, United States Registration Area, 1903-1907 Compared with 1908-1912 443 63 Mortality from Cancer of the Buccal Cavity, by Age, Males, United States Registration Area, 1903-1907 Compared with 1908-1912 444 64 Mortality from Cancer of the Buccal Cavity, by Age, Females, United States Registration Area, 1903-1907 Compared with 1908-1912 444 65 Mortality from Cancer of the Stomach and Liver, by Age, Males, United States Registration Area, 1903-1907 Compared with 1908-1912 445 66 Mortality from Cancer of the Stomach and Liver, by Age, Females, United States Registration Area, 1903-1907 Compared with 1908-1912 445 67 Mortality from Cancer of the Peritoneum, Intestines and Rectum, by Age, Males, United States Registration Area, 1903-1907 Compared with 1908-1912 446 68 Mortality from Cancer of the Peritoneum, Intestines and Rectum, by Age, Fe- males, United States Registration Area, 1903-1907 Compared with 1908-1912 44C 420 APPENDIX F (PART I) Table Page (59 Mortality from Cancer of the Female Generative Organs, by Age, United States Registration Area, 1903-1907 Compared with 1908-1912 447 70 Mortality from Cancer of the Female Breast, by Age, United States Registra- tion Area, 1903-1907 Compared with 1908-1912 447 71 Mortality from Cancer of the Skin, by Age, Males, United States Registration Area, 1903-1907 Compared with 1908-1912 448 72 Mortality from Cancer of the Skin, by Age, Females, United States Registration Area, 1903-1907 Compared with 1908-1912 448 73 Mortality from Cancer of Other or Not Specified Organs and Parts, by Age, Males, United States Registration Area, 1903-1907 Compared with 1908-1912 449 74 Mortality from Cancer of Other or Not Specified Organs and Parts, by Age, Females, United States Registration Area, 1903-1907 Compared with 1908- 1912 449 421 APPENDIX F (PART I) Table 1 Table 2 Estimated Mortality from Cancer Mortality from Cancer Continental United States United States Registration Area 1900 ■1913 1900-1913 Population Cancer Death Estimated Deaths Rate per Year Continental (.ate per 1 OOjOOO U. S. Regis- No. of Deaths Year Population from 100,000 United States tration Area from Cancer Cancer Population 1900 75,994,575 62.9 47,829 1900 30,794,273 19,381 62.9 1901 77,592,344 64.3 49,890 1901 31,370,952 20,171 64.3 1902 79,190,113 65.1 51,542 1902 32,029,815 20,847 65.1 1903 80,787,882 68.3 55,153 1903 32,701,083 22,325 68.3 1904 82,385,651 70.2 57,794 1904 33,349,137 23,395 70.2 1905 83,983,420 71.4 59,931 1905 34,094,605 24,330 71.4 1906 85,581,189 69.1 59,155 1906 41,983,419 29,020 69.1 1907 87,178,958 70.9 61,840 1907 43,016,990 30,514 70.9 1908 88,776,727 71.5 63,494 1908 46,789,913 33,465 71.5 1909 90,374,496 73.8 66,731 1909 50,870,518 37,562 73.8 1910 91,972,266 76.2 70,099 1910 53,843,896 41,039 76.2 1911 93,570,036 74.3 69,494 1911 59,275,977 44,024 74.3 1912 95,167,806 77.0 73,282 1912 60,427,247 46,531 77.0 1913 96,765,576 78.9 76,319 1913 63,298,718 49,928 78.9 Table 3 Table 4 Mortality from Cancer Mortality from Cancer United States Registration States* United States Reg istration Cities 1900 -1913 Rate per 1900-1 J13 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1900 19,965,149 12,769 63.5 1900 21,504,735 13,672 63.6 1901 20,307,043 13,438 66.2 1901 22,252,010 14,450 64.9 1902 20.648,941 13,653 66.1 1902 22,858,803 15,038 65.8 1903 20,990,841 14,650 69.8 1903 23,465,153 16,173 68.9 1904 21,336,715 15,247 71.5 1904 21,041,724 17,040 70.9 1905 21,736,908 15,983 73.5 1905 24,729,925 17,670 71.5 1906 33,836,029 23,399 69.2 1906 26,342,431 19,492 74.0 1907 34,608,896 24,666 71.3 1907 27,145,619 20,384 75.1 1908 38.705,861 27,617 71.4 1908 28,501,322 21,602 75.8 1909 44,281,685 32,723 73.9 1909 29,655,238 23,325 78.7 1910 47,807,766 36,364 76.1 1910 31,223,935 25,180 80.6 1911 54,385,234 40,229 74.0 1911 32,376i200 26,310 81.3 1912 55,252,123 42,464 76.9 1912 33,304,948 27,949 83.9 1913 58,312,595 45,833 78.6 1913 34,230,283 29,767 87.0 'Includes District of Columbia Table 5 Table 6 Mortality from Cancer, California Mortality from Cancer, Colorado 1906- 1913 Rate per 1906-1913 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1906 2,034,859 1,517 74.6 1906 699,451 316 45.2 1907 2,125,238 1,606 75.6 1907 725,712 346 47.7 1908 2,215,618 1,774 80.1 1908 751,973 402 53.5 1909 2,305,998 1,983 86.0 1909 778,234 419 53.8 1910 2,396,378 2,013 84.0 1910 804,495 468 58.2 1911 2,480,757 2,053 82.6 1911 830,755 459 55.3 1912 2,577,137 2,338 90.7 1912 857,016 497 58.0 1913 2,067,516 2,003 97.6 1913 883,276 448 50.7 422 APPENDIX F {PART I) Table 7 Mortality from Cancer, Connecticut 1900-1913 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 Population 910,161 931,055 951,949 972,844 993,739 1,014,634 1,035,529 1,056,424 1,077,319 1,098,214 1,119,109 1,140,003 1,160,898 1,181,793 Deaths from Cancer 624 650 643 731 670 751 811 819 790 882 893 895 945 1,006 Rate per 100,000 Population 68.6 69.8 67.5 75.1 67.4 74.0 78.3 77.5 73.3 80.3 79.8 78.5 81.4 85.1 Table 9 Mortality from Cancer, Kentucky 1911-1913 Table 8 Mortality from Cancer, Indiana 1900-1913 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 Population 2,518,018 2,536,692 2,555,307 2,574,042 2,592,717 2,611,392 2,630,067 2,648,742 2,667,417 2,686,092 2,704,767 2,723,441 2,742,117 2,760,792 Deaths from Cancer 1,077 1,125 1,237 1,289 1,334 1,482 1,456 1,567 1,795 1,856 1,898 1,943 2,030 2,239 Rate per 100,000 Population 42.8 44.3 48.4 50.1 51.5 56.8 55.4 59.2 67.3 69.1 70.2 71.3 74.0 81.1 Table 10 Mortality from Cancer, Maine 1900-1913 Year 1911 1912 1913 Population 2,307,369 2,321,823 2,336,277 Deaths from Cancer 986 1,043 1,122 Rate per 100,000 Population 42.7 44.9 48.0 Year 1906 1907 1908 1909 1910 1911 1912 1913 Table 11 Mortality from Cancer Maryl and, 190 6-1913 Deaths Rate per Population 1,254,146 1,265,012 1,275,878 1,286,744 1,297,610 1,308,476 1.319,343 1,330,209 from Cancer 767 785 821 800 942 955 1,042 1.102 100,000 Population 61.2 62.1 64.3 62.2 72.6 73.0 79.0 82.8 Deaths Year Population from Cancer 1900 694,870 518 1901 699,721 575 1902 704,572 608 1903 709,423 599 1904 714,274 611 1905 719,125 661 1906 723,976 616 1907 728,827 727 1908 733,678 695 1909 738,530 727 1910 743,382 754 1911 748,233 738 1912 753,085 829 1913 757,936 815 Rate per 100,000 Population 74.5 82.2 86.3 84.4 85.5 91.9 85.1 99.7 94.7 98.4 101.4 98.6 110.1 107.5 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 Table 12 Mortality from Cancer Massach usetts, 1900-1913 Deaths Population 2,805,346 2,845,012 2,884,679 2,924,346 2,964,013 3,015,?73 3,089,029 3,162,186 3,235,343 3,308,500 3,381,657 3,454,813 3,491,888 3,548,705 from Cancer 2,092 2,183 2,233 2,367 2,607 2,682 2,748 2,883 2,927 2,972 3,159 3,262 3,407 3,597 Rate per 100,000 Population 74.6 76.7 77.4 80.9 88.0 88.9 89.0 91.2 90.5 89.8 93.4 94.4 97.6 101.4 APPENDIX F {PART I) Table 13 Table 14 Mortality from Cancer, Michigan Mortality from Cancer, Minnesota 1900-1913 Rate per 1910-1913 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer PopulatioE 1900 2,420,982 1,482 61.2 1910 2,079,801 1,400 67.3 1901 2,448,240 1,468 60.0 1911 2,099,451 1,423 67.8 1902 2,475,498 1,476 59.6 1912 2,148,235 1,498 69.7 1903 2,502,757 1,689 67.5 1913 2,181,077 1,638 75.1 1904 2,533,990 1,706 67.3 1905 2,581.676 1,643 63.6 1906 2,629,362 1,748 66.5 1907 2,677,048 1,741 65.0 1908 2,724,734 1,924 70.6 1909 2,772,421 1,953 70.4 1910 2,820,108 2,112 74.9 1911 2,867,794 2,137 74.5 1912 2,897,207 2,276 78.6 1913 2,936,618 2,392 81.5 Table 15 Table 16 Mortality from Cancer, Missouri Mortality from Cancer, Montana 1911- ■1913 Rate per 1910-1913 Deaths Deaths Rate per Year Population from Cancer 100,000 Population Year Population from 100,000 Cancer Populatioi 1911 3,321,094 1,974 59.4 1910 378,853 157 41.4 1912 3,335,080 2,142 64.2 1911 392,293 157 40.0 1913 3,353,983 2,250 67.1 1912 1913 405,734 419,174 164 40.4 207 49.4 Table 17 Mortality from Cancer New Hampshire 1900-1913 Deaths Rate per Year Population from 100,000 Cancer Population 1900 411,748 296 71.9 1901 413,670 364 88.0 1902 415,592 340 81.8 1903 417,514 327 78.3 1904 419,436 342 81.5 1905 421,358 359 85.2 1906 423,280 386 91.2 1907 425,203 418 98.3 1908 427,126 384 89.9 1909 429,049 401 93.5 1910 430,972 424 98.4 1911 432,894 419 96.8 1912 434,818 467 107.4 1913 436,740 456 104.4 424f APPENDIX F {PART I) Table 18 Table 19 Mortality from Cancer Mortality from Cancer New J ersey New York 1900- 1913 Rate per 1900-1913 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1900 1,883,669 1,016 53.9 1900 7,268,894 4,847 66.7 1901 1,935,763 1,126 58.2 1901 7,428,576 5,186 69.8 190^ 1,987,858 1,064 53.5 1902 7,588,259 5,227 68.9 1903 2,039,953 1,189 58.3 1903 7,747,942 5,558 71.7 1904 2,092,048 1,205 57.6 1904 7,907,625 5,834 73.8 1905 2,150,861 1,356 63.0 1905 8,085,194 6,139 75.9 1906 2,231,481 1,451 65.0 1906 8,299,820 6,273 75.6 1907 2,312,101 1,470 63.6 1907 8,514,447 6,614 77.7 1908 2,392,721 1,553 64.9 1908 8,729,074 6,797 77.9 1909 2,473,342 1,681 68.0 1909 8,943,701 7,262 81.2 1910 2,553,963 1,891 74.0 1910 9,158,328 7,726 84.4 1911 2,634,583 1,966 74.6 1911 9,372,954 8,091 86.3 1912 2,683,309 2,054 76.5 1912 9,526,146 8,209 86.2 1913 2,749,486 2,156 78.4 1913 9,712,954 8,531 87.8 Table 20 Table 21 Mortality from Cancer, N. Carolina * Mortality from Cancer, Ohio 1910- 1913 Rate per 1909-1913 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1910 361,941 171 47.2 1909 4,718,251 3,470 73.5 1911 374,314 205 54.8 1910 4,779,981 3,599 75.3 1912 385,790 219 56.8 1911 4,841,710 3,699 76.4 1913 396,927 190 47.9 1912 4,903,439 3,936 80.3 • Includes only municipalities having a population 1913 4,965,169 4,061 81.8 of 1,000 or over in 1900. Table 22 Mortality from Cancer,Pennsylvania 1906-1913 Deaths Rate per Year Population from 100,000 Cancer Population 1906 7.141,766 4,208 58.9 1907 7,279,791 4,420 60 7 1908 7,417,816 4,520 60 9 1909 7,555,841 4,845 64 1 1910 7,693,866 5,100 66.3 1911 7,831,890 5,197 66.4 1912 7,969,916 5,426 68.1 1913 8,107,942 5,854 72.2 425 APPENDIX F {PART I) Table 23 Table 24 Mortality from Cancer Mortality from Cancer Rhode Island South Dakota 1900 -1913 Rate per 1906-1909 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1900 428,556 302 70.5 1906 487,094 165 33.9 1901 438,861 319 72.7 1907 512,622 185 36.1 1902 449,166 370 82.4 1908 538,150 225 41.8 1903 459,471 355 77.3 1909 563,678 172 30.5 1904 4.69,776 407 86.6 1905 481,150 386 80.2 1906 493,976 384 77.7 1907 506,802 456 90.0 1908 519,628 427 82.2 1909 532,455 466 87.5 1910 545,282 474 86.9 1911 558,108 491 88.0 1912 568,114 510 89.8 1913 579,665 541 93.3 Table 25 Table 26 Mortality from Cancer, Utah Mortality from Cancer, Vermont 1910- 1913 Rate per 1900-1913 Deaths Deaths Rate per Year Population from 100.000 Year Population from 100,000 Cancer Population Cancer Population 1910 375,389 134 35.7 1900 343,745 302 87.9 1911 385,171 200 51.9 1901 344,992 243 70.4 1912 394,953 188 47.6 1902 346,239 239 69.0 1913 404,735 211 52.1 1903 347,486 325 93.5 1904 348,733 303 86.9 1905 349,980 294 84.0 1906 351,227 299 85.1 1907 352,474 348 98.7 1908 353,721 325 91.9 1909 354,968 345 97.2 1910 356,216 393 110.3 1911 357,463 361 101.0 1912 358,710 396 110.4 1913 359,957 402 111.7 Table 27 Table 28 Mortality from Cancer, Washington Mortality from Cancer, Wisconsin 1908- 1913 Rate per 1908-1913 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1908 1,028,794 466 45.3 1908 2,295,302 1,513 65.9 1909 1,091,973 559 51.2 1909 2,310,822 1,645 71.0 1910 1,155,152 593 51.3 1910 2,338,343 1,763 75.4 1911 1,218,330 562 46.1 1911 2,359,863 1,763 74.7 1912 1,281,508 679 53.0 1912 2,393,081 1,841 76.9 1913 1,344,086 720 53.5 1913 2,419,898 1.899 78.5 426 APPENDIX F {PART 1) Table 29 Estimated Mortality from Malig- nant and Benign Tumors in Continental United States 1900-1913 Table 30 Estimated Mortality from Benign Tumors in Continental United States 1900-1913 Death Rate Estimated Death Rate Population per 100,000 Deaths from iralignant and Benign Population per 100,000 Estimated Deaths from Year Continental Population Year Continental Population Benign United States U.S.Reg. Area Tumors United States U.S. Reg. Area Tumors 1900 75,994,575 67.3 51,173 1900 75,994,575 4.4 3,344 1901 77,592,344 68.9 5.3,459 1901 77,592,344 4.6 3,569 1902 79,190,113 69.6 55,106 1902 79,190,113 4.5 3,564 1903 80,787,882 73.2 59,112 1903 80,787,882 4.9 3,959 1904 82,385,651 74.7 61,501 1904 82,385,651 4.5 3,707 1905 83,983,420 76.0 63,794 1905 83,983,420 4.6 3,863 1906 85,581,189 73.0 62,493 1906 85,581,189 3.9 3,338 1907 87,178,958 75.1 65,502 1907 87,178,958 4.2 3,662 1908 88,776,727 75.3 66,868 1908 88,776,727 3.8 3,374 1909 90,374,496 77.5 70,075 1909 90,374,496 3.7 3,344 1910 91,972,266 79.9 73,502 1910 91,972,266 3.7 3,403 1911 93,570,036 77.7 72,675 1911 93,570,036 3.4 3,181 1912 95,167,806 80.3 76,423 1912 95,167,806 3.3 3,141 1913 96,765,576 82.2 79,567 1913 96,765,576 3.4 3,248 Table 31 Table 32 Mortality from Cancer, United Mortality from Cancer, United States Registration Area States Registration Area Males Females 1900-1913 Rate per 1900-] 1913 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1900 15,415,757 7,294 47.3 1900 15,378,516 12,087 78.6 1901 15,742,434 7,706 49.0 1901 15,628,518 12,465 79.8 1902 16,111,848 7,798 48.4 1902 15,917,967 13,049 82.0 1903 16,489,113 8,422 51.1 1903 16,211,970 13,903 85.8 1904 16,856,270 8,881 52.7 1904 16,492,867 14,514 88.0 1905 17,274,352 9,189 53.2 1905 16,820,253 15,141 90.0 1906 21,322,133 11,166 52.4 1906 20,661,286 17,854 86.4 1907 21,899,144 11,800 53.9 1907 21,117,846 18,714 88.6 1908 23,876,529 13,046 54.6 1908 22,913,384 20,410 89.1 1909 26,020,431 14,918 57.3 1909 24,850,087 22,644 91.1 1910 27,606,526 16,373 59.3 1910 26,237,370 24,666 94.0 1911 30,463,411 17,525 57.5 1911 28,812,566 26,499 92.0 1912 31,128,193 18,464 59.3 1912 29,298,940 28,067 95.8 1913 32,681,358 20,045 61.3 1913 30,617,806 29,883 97.6 427 APPENDIX F (PART I) Table 33 Mortality from Benign Tumors United States Registration Area 1900-1913 Ali. Htdatid Tumor Tumor Tumor of Specified Fobus Tumor of Liveb OF Uterus OF Ovaries Other Obqans Rate per Rate per Rate per Rate per Rate per Year Deaths 100,000 Deaths 100,000 Deaths 100,000 Deaths 100,000 Deaths 100,000 ?opulatioii Population Population Population Population 1900 1,343 4.4 10 0.03 403 1.3 349 1.1 581 1.9 1901 1,453 4.6 8 0.03 529 1.7 411 1.3 505 1.6 1902 1,437 4.5 14 0.04 536 1.7 428 1.3 459 1.4 1903 1,587 4.9 9 0.03 608 1.9 439 1.3 531 1.6 1904 1,509 4.5 12 0.04 620 1.9 433 1.3 444 1.3 1905 1,566 4.6 14 0.04 611 1.8 440 1.3 501 1.5 1906 1,645 3.9 13 0.03 731 1.7 431 1.0 470 1.1 1907 1,786 4.2 9 0.02 813 1.9 456 1.1 508 1.2 1908 1,770 3.8 13 0.03 845 1.8 454 1.0 458 1.0 1909 1,857 3.7 19 0.04 862 1.7 518 1.0 458 0.9 1910 2,010 3.7 24 0.04 933 1.7 500 0.9 553 1.0 1911 1,999 3.4 24 0.04 892 1.5 628 1.1 455 0.8 1912 2,001 3.3 25 0.04 1,053 1.7 546 0.9 377 0.6 1913 2,125 3.4 15 0.02 1,173 1.9 640 1.0 297 0.5 Table 34 Mortality from Benign Tumors, Males United States Registration Area 1900-1913 All Specified Forms Hydatid Tumor of Liver TuMOB OF Other Organs Rate per Rate per Rate per Year Deaths 100,000 Population Deaths 100,000 Population Deaths 100,000 Population 1900 165 1.1 8 0.05 157 1.0 1901 154 1.0 3 0.02 151 1.0 1902 129 0.8 6 0.04 123 0.8 1903 158 1.0 6 0.04 152 0.9 1904 120 0.7 7 0.04 113 0.7 1905 148 0.9 11 0.06 137 0.8 1906 124 0.6 9 0.04 115 0.5 1907 146 0.7 6 0.03 140 0.6 1908 122 0.5 5 0.02 117 0.5 1909 136 0.5 8 0.03 128 0.5 1910 162 0.6 20 0.07 142 0.5 1911 127 0.4 11 0.04 116 0.4 1912 109 0.4 13 0.04 96 0.3 1913 97 0.3 9 0.03 88 0.3 428 APPENDIX F (PART I) Table 35 Mortality from Benign Tumors, Females United States Registration Area 1900-1913 All Specified Forms Hydatid Tumor of Liver Tumor of Uterus Tumor OF Ovaries Tumor of Other Organs Year Deaths Rate per 100,000 Population Rate per Deaths 100,000 Population Deaths Rate per 100,000 Population Deaths Rate per 100,000 Population Deaths Rate per 100,000 Population 1900 1,178 7.7 2 0.01 403 2.6 349 2.3 424 2.8 1901 1,299 8.3 5 0.03 529 3.4 411 2.6 354 2.3 1902 1,308 8.2 8 0.05 536 3.4 428 2.7 336 2.1 1903 1,429 8.8 3 0.02 608 3.8 439 2.7 379 2.3 1904 1,389 8.4 5 0.03 620 3.8 433 2.6 331 2.0 1905 1,418 8.4 3 0.02 611 3.6 440 2.6 364 2.2 1906 1,521 7.4 4 0.02 731 3.5 431 2.1 355 1.7 1907 1,640 7.8 3 0.01 813 3.8 456 2.2 368 1.7 1908 1,648 7.2 8 0.03 845 3.7 454 2.0 341 1.5 re09 1,721 6.9 11 0.04 862 3.5 518 2.1 330 1.3 1910 1,848 7.0 4 0.02 933 3.6 500 1.9 411 1.6 1911 1,872 6.5 13 0.05 892 3.1 628 2.2 339 1.2 1912 1,892 6.5 12 0.04 1,053 3.6 546 1.9 281 1.0 1913 2,028 6.6 6 0.02 1,173 3.8 640 2.1 209 0.7 Table 36 Mortality from Ulcer of the Stomach, by Sex United States Registration Area 1900-1913 Total Males Females Year Deaths Rate per 100,000 Population Deaths Rate per 100,000 Population Deaths Rate per 100,000 Population 1900 804 2.6 419 2.7 385 2.5 1901 871 2.8 439 2.8 432 2.8 1902 905 2.8 465 2.9 440 2.8 1903 905 2.8 465 2.8 440 2.7 1904 1,044 3.1 524 3.1 520 3.2 1905 1,094 3.2 615 3.6 479 2.8 1906 1,423 3.4 731 3.4 692 3.3 1907 1,481 3.4 802 3.7 679 3.2 1908 1,523 3.3 866 3.6 657 2.9 1909 1,770 3.5 1,009 3.9 761 3.1 1910 2,203 4.1 1,273 4.6 930 3.5 1911 2,143 3.6 1,222 4.0 921 3.2 1912 2,316 3.8 1,398 4.5 918 3.1 1913 2,536 4.0 1,483 4.5 1,053 3.4 429 APPENDIX F (PART I) Table 37 Mortality from Biliary Calculi, by Sex United States Registration Area 1900-1913 To PAL Males Females Year Deaths Rate per 100,000 Population Deaths Rate per 100,000 Population Deaths Rate per 100,000 Population 1900 459 1.5 149 1.0 310 2.0 1901 500 1.6 145 0.9 355 2.3 1902 668 2.1 219 1.4 449 2.8 1903 795 2.4 235 1.4 560 3.5 1904 832 2.5 264 1.6 568 3.4 1905 883 2.6 263 1.5 620 3.7 1906 1,134 2.7 338 1.6 796 3.9 1907 1,110 2.6 343 1.6 767 3.6 1908 1,275 2.7 377 1.6 898 3.9 1909 1,486 2.9 447 1.7 1,039 4.2 1910 1,501 2.8 461 1.7 1,040 4.0' 1911 1,749 3.0 510 1.7 1,239 4.3 1912 1,793 3.0 529 1.7 1,264 4.3 1913 1,999 3.2 595 1.8 1,404 4.6 Table 38 Mortality from Calculi of the Urinary Tract, by Sex United States Registration Area 1900-1913 Total Males Females Year Deaths Rate per 100,000 Population Deaths Rate per 100,000 Population Deaths Rate per 100,000 Population 1900 116 0.4 82 0.5 34 0.2 1901 126 0.4 95 0.6 31 0.2 1902 150 0.5 118 0.7 32 0.2 1903 151 0.5 113 0.7 38 0.2 1904 154 0.5 121 0.7 33 0.2 1905 193 0.6 141 0.8 52 0.3 1906 227 0.5 170 0.8 57 0.3 1907 229 0.5 163 0.7 66 0.3 1908 250 0.5 175 0.7 75 0.3 1909 292 0.6 218 0.8 74 0.3 1910 329 0.6 241 0.9 88 0.3 1911 361 0.6 260 0.9 101 0.4 1912 358 0.6 247 0.8 111 0.4 1913 403 0.6 291 0.9 112 0.4 430 APPENDIX F {PART 1) Table 39 Comparative Mortality from Cancer, by Race, United States Registration Area, 1910-1912 WHITE Year Population 1910. 51,690,975 1911 56,763,765 1912 57,874,275 Deaths Rate per from 100,000 Cancer Population 39,875 77.1 42,593 75.0 45,076 77.9 1910-1912 166,329,015 127,544 76.7 COLORED 1910 2,152,921 1,164 54.1 1911 2,512,212 1,431 57.0 1912 2,552,858 1,455 57.0 1910-1912 7,217,991 4,050 56.1 Table 40 Comparative Urban and Rural Mortality from Cancer, United States Regis- tration States, 1900-1913 URBAN Year Population 1900 10,675,611 1901 11,188,101 1902 11,477,929 1903 11,754,911 1904 12,029,302 1905 12,372,228 1906 18,195,041 1907 18,737,525 1908 20,417,270 1909 23,066,405 1910 25,187,805 1911 27,485,457 1912 28,129,824 1913 29,244,160 25,672 87.8 RURAL 1900 9,289,538 1901 9,118,942 1902 9,171,012 1903 9,235,930 1904 9,307,413 1905 9,364,680 1906 15,640,988 1907 15,871,371 1908 18,288,591 1909 21,215,280 1910 22,619,961 1911 26,899,777 1912 27,122,299 1913 29,068,435 431 Deaths Rate per from 100,000 Cancer Population 7,060 66.1 7,717 69.0 7,844 68.3 8,498 72.3 8,892 73.9 9,323 75.4 13,871 76.2 14,536 77.6 15,754 77.2 18,486 80.1 20,505 81.4 22,515 81.9 23,882 84.9 5,709 61.5 5,721 62.7 5,809 63.3 6,152 66.6 6,355 68.3 6,660 71.1 9,528 60.9 10,130 63.8 11,863 64.9 14,237 67.1 15,859 70.1 17,714 65.9 18,582 68.5 20,161 69.4 APPENDIX F {PART I) Table 41 Mortality from Cancer of the Buccal Cavity, by Sex United States Registration Area 1900-1913 Total Males Females Deaths Rate per Deaths Rate per Deaths Rate per Year from 100,000 from 100,000 from 100,000 Cancer Population Cancer Population Cancer Population 1900 495 1.6 377 2.4 118 0.8 1901 612 2.0 496 3.2 116 0.7- 1902 583 1.8 461 2.9 122 0.8 1903 661 2.0 527 3.2 134 0.8 1904 737 2.2 591 3.5 146 0.9 1905 792 2.3 643 3.7 149 0.9 1906 941 2.2 762 3.6 179 0.9 1907 968 2.3 788 3.6 180 0.9 1908 1,148 2.5 950 4.0 198 0.9 1909 1,427 2.8 1,195 4.6 232 0.9 1910 1,576 2.9 1,329 4.8 247 0.9 1911 1,727 2.9 1,402 4.6 325 1.1 1912 1,838 3.0 1,465 4.7 373 1.3 1913 1.966 3.1 1,628 5.0 338 1.1 Table 42 Mortality from Cancer of the Stomach and Liver, by Sex United States Registration Area 1900-1913 Total Males Females Deaths Rate per Deaths Rate per Deaths Rate per Year from 100,000 from 100,000 from 100,000 Cancer Population Cancer Population Cancer Population 1900 6,918 22.5 3,418 22.2 3,500 22.8 1901 7,095 22.6 3,594 22.8 3,501 22.4 1902 7.483 23.4 3,681 22.8 3,802 23.9 1903 8,193 25.1 4,037 24.5 4,156 25.6 1904 8,744 26.2 4,340 25.7 4,404 26.7 1905 8,939 26.2 4,388 25.4 4,551 27.1 1906 10,946 26.1 5,443 25.5 5,503 26.6 1907 11,596 27.0 5,779 26.4 5,817 27.5 1908 13,044 27.9 6,537 27.4 6,507 28.4 1909 14,915 29.3 7,477 28.7 7,438 29.9 1910 16,475 30.6 8,135 29.5 8,340 31.8 1911 17,365 29.3 8,698 28.6 8,667 30.1 1912 18,517 30.6 9,215 29.6 9,302 31.7 1913 19,767 31.2 9,749 29.8 10,018 32.7 432 APPENDIX F {PART I) Table 43 Mortality from Cancer of the Peritoneum, Intestines and Rectum, by Sex United States Registration Area 1900-1913 ToTAi Males Fem-u, E3 Deaths Rate per Deaths Rate per Deaths Rate per Year from 100,000 from 100,000- from 100,000 Cancer Population Cancer Population Cancer Population 1900 1,7G0 5.7 792 5.1 968 6.3 1901 2.157 6.9 935 5.9 1,222 7.8 1902 2.239 7.0 1,014 6.3 1,225 7.7 1903 2,134 6.5 899 5.5 1,235 7.6 1904 2,399 7.2 1,054 6.3 1,345 8.2 1905 2,732 8.0 1,129 6.5 1,603 9.5 1906 3,273 7.8 1,320 6.2 1,953 9.5 1907 3,570 8.3 1,497 6.8 2,073 9.8 1908 3,963 8.5 1,649 6.9 2,314 10.1 1909 4,676 9.2 1,961 7.5 2,715 10.9 1910 5,258 9.8 2,183 7.9 3,075 11.7 1911 5,824 9.8 2,464 8.1 3,360 11.7 1912 5,923 9.8 2,459 7.9 3,464 11.8 1913 6,625 10.5 2,811 8.6 3,814 12.5 Table 44 Mortality from Cancer of the Female Generative Organs and Female Breast United States Registration Area 1900-1913 Female Generative Organs Female Breast Year Deaths from Cancer Rate per 100,000 Total Population Rate per 100,000 Female Population Deaths from Cancer Rate per 100,000 Total Population Rate per 100,000 Female Population 1900 2,696 8.8 17.5 1,400 4.5 9.1 1901 2,919 9.3 18.7 1,621 5.2 10.4 1902 3,033 9.5 19.1 1,734 5.4 10.9 1903 3,289 10.1 20.3 1,777 5.4 11.0 1904 3,436 10.3 20.8 2,019 6.1 12.2 1905 3,637 10.7 21.6 1,994 5.8 11.9 1906 4,090 9.7 19.8 2,421 5.8 11.7 1907 4,388 10.2 20.8 2,590 6.0 12.3 1908 5,250 11.2 22.9 3,023 6.5 13.2 1909 5,714 11.2 23.0 3,585 7.0 14.4 1910 6,147 11.4 23.4 3,730 6.9 14.2 1911 6,707 11.3 23.3 4,190 7.1 14.5 1912 7,089 11.7 24.2 4,356 7.2 14.9 1913 7,706 12.2 25.2 4.514 7.1 14.7 433 APPENDIX F {PART I) Table 45 Mortality from Cancer of the Skin, by Sex United States Registration Area 1900-1913 Total Males Females Deaths Rate per Deaths Rate per Deaths Rate per Year from 100,000 from 100,000 from 100,000 Cancer Population Cancer Population Cancer Population 1900 602 2.0 392 2.5 210 1.4 1901 683 2.2 456 2.9 227 1.5 1902 688 2.1 454 2.8 234 1.5 1903 752 2.3 484 2.9 268 1.7 1904 758 2.3 462 2.7 296 1.8 1905 818 2.4 539 3.1 279 1.7 1906 984 2.3 656 3.1 328 1.6 1907 1,121 2.6 724 3.3 397 1.9 1908 1,282 2.7 827 3.5 455 2.0 1909 1,492 2.9 988 3.8 504 2.0 1910 1,459 2.7 952 3.4 507 1.9 1911 1,619 2.7 1,011 3.3 608 2.1 1912 1,743 2.9 1,079 3.5 664 2.3 1913 1,725 2.7 1,128 3.5 597 1.9 Table 46 Mortality from Cancer of Other or Not Specified Organs and Parts, by Sex United States Registration Area 1900-1913 Total Males Females Deaths Rate per Deaths Rate per Deaths Rate per Year from 100,000 from 100,000 from 100,000 Cancer Population Cancer Population Cancer Population 1900 5,510 17.9 2,315 15.0 3,195 20.8 1901 5,084 16.2 2,225 14.1 2,859 18.3 1902 5,087 15.9 2,188 13.6 2,899 18.2 1903 5,519 16.9 2,475 15.0 3,044 18.8 1904 5,302 15.9 2,434 14.4 2,868 17.4 1905 5,418 15.9 2,490 14.4 2,928 17.4 1906 6,365 15.2 2,985 14.0 3,380 16.4 1907 6,281 14.6 3,012 13.8 3,269 15.5 1908 5,755 12.3 3,083 12.9 2,672 11.7 1909 5,753 11.3 3,297 12.7 2,456 9.9 1910 6,394 11.9 3,774 13.7 2,620 10.0 1911 6,592 11.1 3,950 13.0 2,642 9.2 1912 7,065 11.7 4,246 13.6 2,819 9.6 1913 7,625 12.0 4.729 14.5 2.896 9.5 434 APPENDIX F {PART 1) Table 47 Estimated Total Mortality from Cancer, by Organs and Parts Continental United States 1900- 1913 Peritoneum Female Other Buccal Stomach Intestines Generative Female Organs Year Cuvity and Liver and Rectum Organs Breast Skin or Parts 1000 1,224 17,072 4,343 6,653 3,455 1,485 13,697 1901 1,513 17,548 5,334 7,219 4,009 1,689 12,578 iyo2 1,444 18,500 5,535 7.499 4,287 1,700 12,577 11)03 1,632 20,241 5,271 8,125 4,391 1,857 13,636 1904 1,820 21,001 6,926 8,488 4,988 1,872 13,099 1905 1,950 22,019 6,730 8,959 4,911 2,015 13,347 1906 1,918 22,313 6,671 8,336 4,935 2,005 12,977 1907 1,962 23,500 7,235 8,892 5,248 2,271 12,732 1908 2,178 24,748 7,519 9,961 6,735 2,432 10,921 1909 2,535 26,497 8,306 10,151 6,369 2,650 10,223 1910 2,691 28,141 8,981 10,500 6,371 2,492 10,923 1911 2,726 27,411 9,193 10,587 6,614 2,565 10,408 1912 2,894 29,162 9,327 11,164 6,860 2,745 11,130 1913 3,007 30,215 10,128 11,776 7,021 2,633 11,539 Table 48 Population Statistics,* by Age and Sex, United States Registration Area 1903-1912 1903-1912 1903 ■1907 1908-1912 Ages Males Females Males Females Males Females Under 10 46,012,661 45,163,577 18,792,745 18,479,974 27,219,916 26,683,603 10-24 64,768,033 64,826,435 25,939,027 26,470,106 38,819,006 38,356,330 25-34 41,612,738 38,391,104 16,873,725 16,923,152 24,739,013 22,407,962 35-44 33,236,346 30,097,460 13,479,733 12,267,433 19,755,613 17,830,017 45-54 23,174,947 20,941,618 9,164,393 8,424,322 14,010,554 12,517,296 55-64 13,726,350 13,042,648 5,478,304 5,341,009 8,248,040 7,701,539 65-74 7,452,085 7,602,607 2,946,685 3,061,414 4,506,400 4,641,193 75 and over 2,963,942 3,351,230 1,167,400 1,336,813 1,796,542 2,014,417 All ages 232,936,102 223,416,569 93,841,012 91,304,222 139,096,090 132,112,347 45 and over 47,317,324 44,938,003 18,765,782 18,163,658 28,561,642 26,774,445 •Midyear estimates. 435 APPENDIX F {PART I) Table 49 Mortality from Cancer of All Organs and Parts, by Age and Sex United States Registration Area 1903-1912 Ages at Death Males Deaths from Cancer Rate per 100,000 Population Females Deaths Rate per from 100,000 Cancer Population Comp of Rate fi Actual arison ifferences Per Cent. Under 10 1,170 2.5 984 2.2 - 0.3 12.0 10-24 2,028 3.1 1,844 2.8 - 0.3 9.7 25-34 3,757 9.0 7,891 20.6 + 11.6 128.9 35-44 10,750 32.3 26,779 89.0 + 56.7 175.5 45-54 24,431 105.4 46,669 222.9 + 117.5 111.5 ■ 55-64 35,327 257.4 50,393 386.4 + 129.0 50.1 65-74 33,745 452.8 43,010 565.7 + 112.9 24.9 75 and over 18,381 620.2 24,601 734.1 +113.9 18.4 All ages* 129,784 55.7 202,421 90.6 + 34.9 62.7 45 and over 111,884 236.5 164,673 366.4 + 129.9 54.9 'Including unknown ages. Table 50 Mortality from Cancer of the Buccal Cavity, by Age and Sex United States Registration Area 1903-1912 Ages at Death Males Deaths from Cancer Rate per 100,000 Population Females Deaths Rate per from 100,000 Cancer Population Comparison of Rate Differences Actual Per Cent. Under 10 58 0.1 45 0.1 ^ , 10-24 79 0.1 49 0.1 , , , , 25-34 131 0.3 58 0.2 - 0.1 33.3 35-44 640 1.9 135 0.4 - 1.5 78.9 45-54 1,829 7.9 303 1.4 - 6.5 82.3 55-64 2,605 19.0 467 3.6 -15.4 81.1 65-74 2,565 34.4 565 7.4 -27.0 78.5 75 and over 1,732 58.4 538 16.1 -42.3 72.4 All ages* 9,652 4.2 2,163 1.0 - 3.2 76.2 45 and over 8,731 18.5 1,873 4.1 -14.4 77.8 *Including unknown ages. 436 APPENDIX F {PART I) Table 51 Mortality from Cancer of the Stomach and Liver, by Age and Sex United States Registration Area 1903-1912 Ages at Death Males Deaths from Cancer Rate per 100,000 Population Females Deaths Rate per from 100,000 Cancer Population Com of Rate Actual jarison Differences Per Cent. Under 10 163 0.3 119 0.2 - 0.1 33.3 10-24 299 0.5 256 0.4 - 0.1 20.0 25-34 1,267 3.1 1,484 3.9 + 0.8 25.8 35-44 5,224 15.7 5,753 19.1 + 3.4 21.7 45-54 13,110 56.6 12,798 61.1 + 4.5 8.0 55-64 19,057 138.8 17,805 136.5 - 2.3 1.7 65-74 17,273 231.8 17,496 230.1 - 1.7 0.7 75 and over 7.569 255.4 8,911 265.9 + 10.5 4.1 All ages* 64,049 27.5 64,685 29.0 + 1.5 5.5 45 and over 57.009 120.5 57,010 126.9 + 6.4 5.3 *lncluding unknown ages. Table 52 Mortality from Cancer of the Peritoneum, Intestines and Rectum by Age and Sex, United States Registration Area 1903-1912 Ages at Death Males Deaths from Cancer Rate per 100,000 Population Females Deaths Rate per from 100,000 Cancer Population Comparison of Rate Differences Actual Per Cent. Under 10 127 0.3 79 0.2 - 0.1 33.3 10-24 349 0.5 246 0.4 - 0.1 20.0 25-34 808 1.9 929 2.4 + 0.5 26.3 35-44 1,636 4.9 2,632 8.8 + 3.9 79.6 45-54 3,130 13.5 4,684 22.4 + 8.9 65.9 55-64 4,523 33.0 5,851 44.9 +11.9 36.1 65-74 4,135 55.5 5,606 73.7 +18.2 32.8 75 and over 1,888 63.7 3,081 91.9 +28.2 44.3 All ages* 16,615 7.1 23,137 10.3 + 3.2 45.1 45 and over 13,676 28.9 19,222 42.8 + 13.9 48.1 'Including unknown ages. 437 APPENDIX F {PART I) Table 53 Mortality from Cancer of the Female Generative Organs and Female Breast, by Age, United States Registration Area 1903-1912 Female Gemerative Organs Ages at Death Under 10 10-24 25-34 35-44 45-54 55-64 65-74 75 and over All ages* 45 and over Deaths from Cancer 31 370 2,989 9,820 14,900 11,920 6,903 .2,756 49,747 36,479 Rate per 100,000 Female Population 0.1 0.6 7.8 32.6 71.2 91.4 90.8 82.2 22.3 81.2 Female Breast Rate per Deaths 100,000 from Female Cancer Population 8 0.0 49 0.1 918 2.4 4,583 15.2 7,528 35.9 7,046 54.0 5,683 74.8 3,836 114.5 29,685 13.3 24,093 53.6 •Including unknown ages. Table 54 Mortality from Cancer of the Skin, by Age and Sex United Spates Registration Area 1903-1912 Ages at Death Males Deaths from Cancer Rate per 100,000 Population Females Deaths Rate per from 100,000 Cancer Population Comparison of Rate Differences Actual Per Cent Under 10 42 0.1 39 0.1 . , . , 10-24 63 0.1 41 0.1 , , . , 25-34 88 0.2 55 0.1 - 0.1 50.0 35-44 359 1.1 169 0.6 - 0.5 45.5 45-54 913 3.9 391 1.9 - 2.0 51.3 55-64 1,559 11.4 657 5.0 - 6.4 56.1 65-74 2,138 28.7 1,064 14.0 -14.7 51.2 75. and over 2,544 85.9 1,880 56.1 -29.8 34.7 All ages* 7,722 3.3 4,306 1.9 - 1.4 42.4 45 and over 7,1.54 15.1 3,992 8.9 - 6.2 41.1 •Including unknown ages. 438 APPENDIX F (PART I) Table 55 Mortality from Cancer of Other or Not Specified Organs and Parts,* by Age and Sex, United States Registration Area 1903-1912 Ages at Death M.U.E3 Deaths from Cancer Rate per 100,000 Population Fem. Deaths from Cancer ILES Rate per • 100,000 Population Comparison of Rate Differences Actual Per Cent Under 10 780 1.7 663 1.5 - 0.2 11.8 10-^4 1,238 1.9 833 1.3 - 0.6 31.6 25-3-i 1,463 3.5 1,458 3.8 + 0.3 8.6 35-44. 2,891 8.7 3,687 12.3 + 3.6 41.4 45-54 5,449 23.5 6,065 29.0 + 5.5 23.4 55-64 7,583 55.2 6,647 51.0 - 4.2 7.6 65-74 7,634 102.4 5,693 74.9 -27.5 26.9 75 and over 4.648 156.8 3,599 107.4 -49.4 31.5 All agesf 31,746 13.6 28,698 12.8 - 0.8 5.9 45 and over 25,314 53.5 22,004 48.9 - 4.6 8.6 'Including cancer of the male breast, tincluding unknown ages. Table 56 Mortality from Cancer, Urban and Rural, by Organs and Parts United States Registration States 1908-1912 Rate per 100,000 Population Cancer Per Cent. 2.9 3.6 31.3 38.4 11.2 13.7 13.2 16.2 7.6 9.4 2.1 2.6 13.0 16.1 URBAN Deaths from Organ or Part Cancer Buccal cavity 3,627 Stomach and liver 38,869 Peritoneum, intestines and rectum 13,888 Female generative organs 16,377 Breast 9,499 Skin 2,659 Other or not specified organs 16,223 All organs 101,142 RURAL Buccal ca\-ity 3,226 Stomach and liver 32,518 Peritoneum, intestines and rectum 9,165 Female generative organs 10,158 Breast 7,689 Skin 4,205 Other or not specified organs 11,294 All organs 78,255 81.3 67.3 100.0 4.1 41.6 11.7 13.0 9.8 5.4 14.4 100.0 439 APPENDIX F {PART I) Table 57 Proportionate Mortality from Cancer, by Age and Sex United States Registration Area 1908-1912 JIALES FEMALES Deaths from Deaths from Cancer Deaths from Deaths from Cancer Ages at Death All Causes Cancer Per Cent. All Causes Cancer Per Cent. Under 5 559,943 489 0.1 457,896 436 0.1 6- 9 44,712 226 0.5 40,581 167 0.4 10-14 29,619 195 0.7 27,239 176 0.6 15-19 50,540 361 0.7 47,012 334 0.7 20-24 79,135 632 0.8 68,824 581 0.8 25-29 86,620 928 1.1 72,500 1,451 2.0 30-34 89,576 1,302 1.5 70,275 3,138 4.5 35-39 101,203 2,409 2.4 75,101 6,151 8.2 40-44 102,469 3,844 3.8 71,142 9,560 13.4 45-49 109,083 6,198 5.7 74,773 12,841 17.2 50-54 118,046 8,724 7.4 83,094 15,040 18.1 55-59 116,007 10,237 8.8 86,075 14,990 17.4 60-64 127,186 11,627 9.1 101,475 15,207 15.0 65-69 133,478 11,546 8.7 115,105 14.513 12.6 70-74 129,176 9,611 7.4 118,788 11,938 10.0 75-79 114,101 6,878 6.0 110.598 8,700 7.9 80-84 78,996 3,381 4.3 84,061 4,496 6.3 85-89 40,663 1,305 3.2 47,809 1.888 3.9 90-94 12,801 299 2.3 17,635 497 2.8 95 and over 3,362 62 1.8 5,458 104 1.9 Unknown 3.555 72 •• 1,347 . 87 All ages 2,130,271 80,326 3.8 1,776,788 122,295 6.9 Under 15 634,274 910 0.1 525,716 779 0.1 15-44 509,543 9,476 1.9 404,854 21,215 5.2 45-64 470,322 36,786 7.8 345,417 58,078 16.8 65 and over 512,577 33,082 6.5 499,454 42,136 8.4 Table 58 Relative Mortality from Cancer and Other Important Causes of Death by Age and Sex, United States Registration Area 1908-1912 All Causes Typhoid fever Pul. tuberculosis Cancer Apoplexy Heart diseases Pneumonia Digestive diseases .... Nephritis Suicides Accidents •Including unknown ages. TOTAL All Ages* Under 45 45 AND Over Per Cent, of AH PerCent. of All Deaths Deaths Known Ages Deaths Known Ages ,907.059 2,074,387 53.2 1,827,770 46.8 57,208 47,611 83.4 9,497 16.6 366,075 267,167 73.1 98,521 26.9 202,621 32,380 16.0 170,082 84.0 198,657 17,752 8.9 180,698 91.1 421,580 87,093 20.7 334,073 79.3 369,966 222,493 60.2 147,213 39.8 480,614 352,730 73.4 127,696 26.6 265,665 63,852 24.1 201,590 75.9 44,602 24,507 55.2 19,911 44.8 224,061 145,328 65.3 77,392 34.7 440 APPENDIX F {PART I) Table 58 (concluded) Relative Mortality from Cancer and Other Important Causes of Death by Age and Sex, United States Registration Area 1908-1912 All Ages* Deaths All causes 2.130,271 Typhoid fever 34,206 Pul. tuberculosis 207,603 Cancer 80,326 Apoplexy 101,751 Heart diseases 223,934 Pneumonia 203,946 Digestive diseases .... 257,919 Nephritis 149,535 Suicides 34,348 Accidents 173,457 All causes 1,776,788 Typhoid fever 23,002 Pul. tuberculosis 158,472 Cancer 122,295 Apoplexy 96,906 Heart diseases 197,646 Pneumonia 166,020 Digestive diseases .... 222,695 Nephritis 116,130 Suicides 10,254 Accidents 50,604 MALES Under 45 Per Cent, of All Deaths Known Ages 1,143,817 53.8 28,444 143,593 10,386 9,771 44,023 127,156 191,583 33,251 17,512 117,604 FEMALES 930,570 19,167 123,574 21,994 7,981 43,070 95,337 161,147 30,601 6,995 27,724 83.3 69.2 12.9 9.6 19.7 62.4 74.3 22.3 51.2 68.3 52.4 83.4 78.1 18.0 8.2 21.8 57.5 72.4 26.4 68.3 54.9 45 AND Over Per Cent, of All Deaths Known Ages 982.899 46.2 5,694 63,791 69,868 91,846 179,656 76,637 66,221 116,142 16,666 64,588 844,871 16.7 30.8 87.1 90.4 80.3 37.6 25.7 77.7 48.8 31.7 47.6 3,803 16.6 34,730 21.9 100,214 82.0 88,852 91.8 154,417 78.2 70,576 42.5 61,475 27.6 85,448 73.6 3,245 31.7 22,804 45.1 *Including unknown ages. Table 59 Mortality from Cancer in the States of New York, Massachusetts, New Hampshire and Connecticut, by Months 1902-1911 Mean Months Population* January 131,540,322 February.. .. 120,069,048 March 132,048,497 April 128,030,367 May 132,571,692 June 128,540,835 July 133,094,888 Deaths Rate per Deaths Rate per from 100,000 Mean from 100,000 Cancer Population Months Population* Cancer Population 8,300 6.3 August 133,360,781 8,941 6.7 7,721 6.4 September. 129,300,297 8,543 6.6 8,600 6.5 October . . . 133,883,987 9,017 6.7 8,315 6.5 November. . 129,806,603 8,477 6.5 8,576 6.5 December. . 134,407,183 8,804 6.6 8,123 6.3 Monthly 8,613 6.5 Average . . . 130,554,542 8,503 6.5 *Population has been standardized for variation in length of month. 441 APPENDIX F (PART I) Table 60 Comparative Death Rate from Cancer, 1901 and 1911, according to Age and Sex, in the States Included in the Registration Area in 1900* Rate per 100,000 Population Total Per Cent. Which Rate in 1911 Age Period 1901 1911 Represents of That in 1901 All ages : Crude rate 65.8 62.2 83.9 77.6 128 Standardized ratef 125 Under 5 years .... 3.4 3.0 88 5- 9 years . 1.0 1.2 120 10-14 " . 0.9 1.3 144 15-19 " . 2.1 2.3 110 20-24 " . 3.9 4.8 123 25-34 " . 13.4 13.9 104 35-44 " . 60.2 61.0 101 45-54 " . 146.5 166.3 114 55-64 " . 268.3 352.4 131 65-74 " . 418.8 566.7 135 75 and over. . . 557.6 794.7 143 25 years and over: Crude rate. ... 124.5 127.2 155.7 159.0 125 Standardized n itef 125 Males Per Cent. Which Rate in 1911 Females Per Cent. Which Rate in 1911 Age Period 1901 1911 Represents of That b 1901 Age Period 1901 1911 Represents of That in 1901 All ages: All ages: Crude rate. . . 48.7 64.2 132 Crude rate . . . 83.0 104.0 125 Stand'r'zedratef 43.6 56.7 130 Stand'r'zedratef 79.7 97.2 122 Under 5 years 3.8 3.1 82 Under 5 years 3.1 3.0 97 5- 9 years 1.3 1.3 100 5- 9 years 0.8 1.1 138 10-14 " 0.9 1.0 111 10-14 " 0.9 1.5 167 15-19 " 1.9 2.9 153 15-19 " . 2.2 1.7 77 20-24 " 3.3 4.9 148 20-24 " 4.5 4.6 102 25-34 " 9.4 8.7 93 25-34 " 17.5 19.4 111 35-44 " 32.5 31.1 96 35-44 " 89.6 92.5 103 45-54 " . 90.0 109.2 121 45-54 " . 205.4 227.0 111 55-64 " . 203.8 283.4 139 55-64 " . 331.8 422.3 127 65-74 " . 366.0 512.8 140 65-74 " . 468.9 617.8 132 75 and over. . . 520.8 730.5 140 75 and over. . . 589.8 848.7 144 25 years and o-^ •er: 25 years and o ver: Crude rate.. . 90.9 117.7 129 Crude rate. . . . 158.7 195.0 123 Stand'r'zedrat et 90.4 117.9 130 Stand'r'zedrat ef 160.3 195.9 122 •Includes Connecticut, the District of Columbia, Indiana, Maine, Massachusetts, Michigan, New Hamp- shire, New Jersey, New York, Rhode Island and Vermont. fStandardized on basis of standard million of England and Wales, 1901. 442 APPENDIX F (PART I) Table 61 Mortality from Cancer of All Organs and Parts, according to Age United States Registration Area 1903-1907 Compared with 1908-1912 Males 1903-1907 1908 1912 Increase ob Decrease Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 455 2.4 715 2.6 + 0.2 8.3 10-24 840 3.2 1,188 3.1 - 0.1 3.1 25-34 1,527 9.0 2,230 9.0 35-44 4,497 33.4 6,253 31.7 - 1.7 5.1 45-54 9,509 103.8 14,922 106.5 + 2.7 2.6 55-64 13,463 245.7 21,864 265.1 + 19.4 7.9 65-74 12,588 427.4 21,157 469.5 + 42.1 9.9 75 and over 6,466 553.9 11,915 663.2 +109.3 19.7 All ages* 49.458 52.7 80,326 57.7 + 5.0 9.5 45 and over 42,026 224.1 69,858 244.6 + 20.5 9.1 'Including unknown ages. Table 62 Mortality from Cancer of All Organs and Parts, according to Age United States Registration Area 1903-1907 Compared with 1908-1912 Females 1903-1907 1908-1912 Increase or Decreasb Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 381 2.1 603 2.3 + 0.2 9.5 10-24 753 2.8 1,091 2.9 + 0.1 3.6 25-34 3,302 20.7 4,589 20.4 - 0.3 1.4 35-44 11,068 90.2 15,711 88.1 - 2.1 2.3 45-54 18,788 223.0 27.881 222.7 - 0.3 0.1 55-64 20,196 378.1 30,197 392.1 + 14.0 3.7 65-74 16,559 540.9 26,451 582.5 + 41.6 7.7 75 and over 8,916 667.0 15.685 778.6 -i-111.6 16.7 All ages* 80,126 87.8 122,295 92.6 + 4.8 5.5 45 and over 64,459 354.9 100,214 374.3 + 19.4 5.5 •Including unknown ages. 443 APPENDIX F {PART I) Table 63 Mortality from Cancer of the Buccal Cavity, according to Age United States Registration Area 1903-1907 Compared with 1908-1912 Males 1903-1907 1908-1912 InCEEASE OB Decbease Deaths Rate oer Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 18 0.1 40 0.1 + 0.05 50.0 10-24 33 0.1 46 0.1 - 0.01 7.7 25-34 54 0.3 77 0.3 - 0.01 3.1 35-44 261 1.9 379 1.9 - 0.02 1.0 45-54 649 7.1 1,180 8.4 + 1.34 18.9 55-64 908 16.6 1,697 20.6 + 4.00 24.1 65-74 865 29.4 1,700 37.7 + 8.36 28.5 75 and over 516 44.2 1,216 67.7 -f 23.49 53.1 All ages* 3,311 3.5 6,341 4.6 + 1.03 29.2 45 and over 2,938 15.7 5,793 20.3 + 4.62 29.5 •Including unknown ages. Table 64 Mortality from Cancer of the Buccal Cavity, according to Age United States Registration Area 1903-1907 Compared with 1908-1912 Females 1903-1907 1908-191'2 InCBEASE OB Decbease Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 19 0.1 26 0.1 , , , , 10-24 11 0.0 38 0.1 -fO.06 150.0 2.5-34 25 0.1 33 0.1 -0.01 6,3 35-44 54 0.4 81 0.4 -j-0.01 2.3 45-54 121 1.4 182 1.4 -j-0.01 0.7 55-64 195 3.6 272 3.5 -0.12 3.3 65-74 207 6.8 358 7.9 -fl.l2 16.6 75 and over 156 11.7 382 19.0 +7.29 62.5 All ages* 788 0.9 1,375 1.0 +0.18 20.9 45 and over 679 3.7 1,194 4.5 +0.72 19.3 'Including unknown ages. 444 APPENDIX F {PART I) Table 65 Mortality from Cancer of the Stomach and Liver, according to Age United States Registration Area 1903-1907 Compared with 1908-1912 Males 1903-1907 1908-1912 Increase ob Decrease Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 65 0.3 98 0.4 + 0.1 33.3 10-24 120 0.5 179 0.5 25-34 509 3.0 758 3.1 + 0.1 3.3 35-44 2,185 16.2 3,039 15.4 - 0.8 4.9 45-54 5,046 55.1 8,064 57.6 + 2.5 4.5 55-64 7,096 129.5 11,961 145.0 + 15.5 12.0 65-74 6,350 215.6 10,923 242.4 +26.8 12.4 75 and over 2,558 219.1 5,011 278.9 +59.8 27.3 All ages* 23,987 25.6 40,062 28.8 + 3.2 12.5 45 and over 21,050 112.2 35,959 125.9 + 13.7 12.2 *Including unknown ages. Table 66 Mortality from Cancer of the Stomach and Liver, according to Age United States Registration Area 1903-1907 Compared with 1908-1912 Females 1903-1907 1908-1912 Increase or Decrease Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 46 0.3 73 0.3 10-24 107 0.4 149 0.4 25-34 619 3.9 865 3.8 - o.i 2.6 35-44 2,346 19.1 3,407 19.1 45-54 4,989 59.2 7,809 62.4 + 3.2 5.4 55-64 6,727 125.9 11,078 143.9 + 18.0 14.3 65-74 6,488 211.9 11,008 242.4 +30.5 14.4 75 and over 3,069 229.6 5,842 290.0 +60.4 26.3 All ages* 24,431 26.8 40,254 30.5 + 3.7 13.8 45 and over 21,273 117.1 35,737 133.5 +16.4 14.0 'Including unknown ages. 445 APPENDIX F (PART I) Table 67 Mortality from Cancer of the Peritoneum, Intestines and Rectum according to Age, United States Registration Area 1903-1907 Compared with 1908-1912 Males 1903-1907 1908-1912 Increase or Decrease Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 47 0.3 80 0.3 . . 10-24 141 0.5 208 0.6 + 0.1 20.6 25-34 308 1.8 500 2.0 -1- 0.2 11.1 35-44 615 4.6 1,021 5.2 + 0.6 13.0 45-54 1,149 12.5 1,981 14.1 + 1.6 12.8 55-64 1,617 29.5 2,906 35.2 -1- 5.7 19.3 65-74 1,408 47.8 2,727 60.5 -fl2.7 26.6 75 and over 613 52.5 1,275 71.0 +18.5 35.2 All ages* 5,899 6.3 10,716 7.7 + 1.4 22.2 45 and over 4,787 25.5 8,889 31.1 + 5.6 22.0 *Including unknown ages. Table 68 Mortality from Cancer of the Peritoneum, Intestines and Rectum according to Age, United States Registration Area 1903-1907 Compared with 1908-1912 Females 1903-1907 1908-1912 Increase or Decrease Deaths Plate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 28 0.2 51 0.2 . , 10-24 95 0.3 151 0.4 + 0.1 33.3 25-34 357 2.2 572 2.5 + 0.3 13.6 35-44 1,039 8.5 1,593 8.9 + 0.4 4.7 45-54 1,690 20.1 2,994 23.9 + 3.8 18.9 55-64 2,115 39.6 3,736 48.5 -f 8.9 22.5 65-74 1,890 61.7 3,716 81.8 +20.1 32.6 75 and over 975 72.9 2,106 104.5 +31.6 43.3 All ages* 8,209 9.0 14,928 11.3 + 2.3 25.6 45 and over 6,670 36.7 12,552 46.9 +10.2 27.8 'Including unknown ages. 446 APPENDIX F {PART J) Table 69 Mortality frK)in Cancer of the Female Generative Organs according to Age, United States Registration Area 1903-1907 Compared with 1908-1912 1903-1907 1908- 1912 Increase ob Decbease Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 8 0.0 23 0.1 + 0.1 125.0 10-24 134 0.5 236 0.6 + 0.1 20.0 25-34 1,158 7.3 1,831 8.2 + 0.9 12.3 35-44 3,836 31.3 5,984 33.6 + 2.3 7.3 45-54 5,810 69.0 9,090 72.6 + 3.6 5.2 55-64 4,529 84.8 7,391 96.0 + 11.2 13.2 65-74 2,440 79.7 4,463 98.3 + 18.6 23.3 75 and over 886 66.3 1,870 92.8 +26.5 40.0 All ages* 18,840 20.6 30,907 23.4 + 2.8 13.6 45 and over 13,665 75.3 22,814 85.2 + 9.9 13.1 •Including unknown ages. Table 70 Mortality from Cancer of the Female Breast, according to Age United States Registration Area 1903-1907 Compared with 1908-1912 1903-1907 1908-1912 Increase ob Decrease Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 8 0.0 , , , , 10-24 is o.i 34 0.1 , , , , 25-34 343 2.2 575 2.6 + 0.4 18.2 35-44 1,683 13.7 2,900 16.3 + 2.6 19.0 45-54 2,667 31.6 4,861 38.8 + 7.2 22.8 55-64 2,684 50.3 4,362 56.6 + 6.3 12.5 65-74 2,061 67.3 3,622 79.8 + 12.5 18.6 75 and over 1,330 99.5 2,506 124.4 +24.9 25.0 All ages* 10,801 11.8 18,884 14.3 + 2.5 21.2 45 and over 8,742 48.1 15,351 57.3 + 9.2 19.1 •Including unknown ages. 30 447 APPENDIX F (PART I) Table 71 Mortality from Cancer of the Skin, according to Age United States Registration Area, 1903-1907 Compared with 1908-1912 Males 1903-1907 1908-1912 Increase or Decrease Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 8 0.0 34 0.1 + 0.08 200.0 10-24 13 0.1 50 0.1 + 0.08 160.0 25-34 33 0.2 55 0.2 + 0.02 100.0 35-44 143 1.1 216 1.1 + 0.03 2.8 45-54 353 3.9 560 4.0 + 0.15 3.9 55-64 610 11.1 949 11.5 + 0.38 3.4 65-74 795 27.0 1,343 29.8 + 2.81 ■ 10.4 75 and over 903 77.4 1,641 91.3 +13.99 18.1 All ages* 2,865 3.0 4,857 3.5 + 0.44 14.4 45 and over 2,661 14.2 4,493 15.7 + 1.54 10.9 'Including unknown ages. Table 72 Mortality from Cancer of the Skin, according to Age United States Registration Area, 1903-1907 Compared with 1908-1912 Females 1903-1907 1908-1912 Increase or Decrease Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 9 0.0 30 0.1 + 0.06 120.0 10-24 18 0.1 23 0.1 - 0.01 14.3 25-34 28 0.2 27 0.1 - 0.06 33.3 35-44 66 0.5 103 0.6 + 0.04 7.4 45-54 158 1.9 233 1.9 - 0.02 1.1 55-64 272 5.1 385 5.0 - 0.09 1.8 65-74 387 12.7 677 14.9 + 2.27 18.0 75 and over 626 46.8 1,254 62.3 +15.42 32.9 All ages* 1,568 1.7 2,738 2.1 + 0.35 20.3 45 and over 1,443 8.0 2.549 9.5 + 1.58 19.9 •Including unknown ages. 448 APPENDIX F (PART 1) Table 73 Mortality from Cancer of Other or Not Specified Organs and Parts* according to Age United States Registration Area, 1903-1907 Compared with 1908-1912 Males 1903-1907 1908-1912 Increase or Dechease Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 317 1.7 463 1.7 10-24 533 2.0 705 1.8 -0.2 10.6 25-34 623 3.7 840 3.4 -0.3 8.1 35^4 1,293 9.6 1,598 8.1 -1.5 15.6 45-54 2,312 25.2 3,137 22.4 -2.8 11.1 55-64 3,232 59.0 4,351 52.8 -6.2 10.5 65-74 3,170 107.6 4,464 99.1 -8.5 7.9 75 and over 1,876 160.7 2,772 154.3 -6.4 4.0 All agesf 13,396 14.3 18.350 13.2 -1.1 7.7 45 and over 10,590 56.5 14,724 51.6 -4.9 8.7 •Including cancer of the male breast, tincluding unknown ages. Table 74 Mortality from Cancer of Other or Not Specified Organs and Parts* according to Age United States Registration Area, 1903-1907 Compared with 1908-1912 Females 1903-1907 1908-1912 Increase or Decrease Deaths Rate per Deaths Rate per Ages at Death from 100,000 from 100,000 Actual Per Cent. Cancer Population Cancer Population Under 10 271 1.5 392 1.5 10-24 373 1.4 460 1.2 - 6.2 14.3 25-34 772 4.8 686 3.1 - 1.7 35.4 . 35-44 2,044 16.7 1,643 9.2 - 7.5 44.9 45-54 3,353 39.8 2,712 21.7 -18.1 45.5 55-64 3,674 68.8 2,973 38.6 -30.2 43.9 65-74 3,086 100.8 2,607 57.4 -43.4 43.1 75 and over 1,874 140.2 1,725 85.6 -54.6 38.9 All agesf 15,489 17.0 13,209 10.0 - 7.0 41.2 45 and over 11,987 66.0 10,017 37.4 -28.6 43.3 •Including cancer of the male breast, tincluding unknown ages. 449 APPENDIX F {PART II) PART II Cancer Mortality Statistics of States and Cities of THE United States Table State Period Title Page 1 Connecticut 1875-1913 Persons 455 2 Connecticut 1879-1913 Males 456 3 Connecticut 1879-1913 Females 457 4 Maine 1892-1913 Persons 458 5 Maine 1892-1913 Males 458 6 Maine 1892-1913 Females 459 7 Massachusetts 1856-1913 Persons 460 8 Massachusetts 1856-1913 Males 461 9 Massachusetts 1856-1913 Females 462 10 New Hampshire 1884-1913 Persons 463 11 New Hampshire 1887-1913 Males 463 12 New Hampshire 1887-1913 Females 464 13 New Jersey 1879-1913 Persons 465 14 New York 1885-1914 Persons 466 15 Rhodelsland 1871-1913 Persons 467 16 Rhode Island 1871-1913 Males 468 17 Rhode Island 1871-1913 Females 469 18 Vermont 1871-1913 Persons 470 19 Vermont 1871-1896 Males 471 20 Vermont 1871-1896 Females 471 21 New England States, New York and New Jersey 1886-1913 Persons 472 City 22 Twenty Large American Cities . . 1881-1913 Persons 473 23 Southern Cities 1891-1914 White 474 24 Southern Cities 1891-1914 Colored 474 25 Augusta, Ga 1891-1913 Persons 475 26 Augusta, Ga 1891-1912 Males 475 27 Augusta, Ga 1891-1912 Females 476 28 Baltimore, Md 1871-1914 Persons 477 29 Baltimore, Md 1891-1914 White 478 30 Baltimore, Md 1891-1914 Colored 478 31 Baltimore, Md 1893-1902—1903-1912 By Organs and Parts 479 32 Boston, Mass 1881-1914 Persons 479 33 Boston, Mass 1881-1913 Males 480 34 Boston, Mass 1881-1913 Females 481 35 Boston,Mass 1903-1912 ByAgeandSex 482 36 Boston, Mass 1903-1912 By Organs and Parts, according to Sex 482 37 ]{oston. Mass 1903-1912 By Organs and Parts, according to Age, Males 483 450 APPENDIX F {PART II) Table City Period Title Page 38 Boston, Mass 1903-1912 By Organs and Parts, according to Age, Females 483 39 Brooklyn, N. Y 1871-1913 Persons 484 40 Brooklyn, N. Y 1872-1878—1903-1913 Males 485 41 Brooklyn, N. Y 1872-1878—1903-1913 Females 485 42 Buffalo, N. Y 1886-1913 Persons 486 43 Buffalo, N. Y 1904-1905—1908-1913 By Sex 486 44 Charleston, S. C 1881-1914 Persons 487 45 Charleston, S. C 1881-1914 White 488 46 Charleston, S. C 1881-1914 Colored 489 47 Chicago, 111 1871-1913 Persons 490 48 Chicago, 111 1895-1913 Males 491 49 Chicago, 111 1895-1913 Females 491 60 Chicago, 111 1903-1912. .• By Organs and Parts, according to Sex 492 51 Cincinnati, Ohio 1871-1913 Persons 492 52 Cincinnati, Ohio 1891-1913 Males 493 53 Cincinnati, Ohio 1891-1913 Females 493 54 Cleveland, Ohio 1884-1913 Persons 494 55 Cleveland, Ohio 1885-1913 Males 495 56 Cleveland, Ohio 1885-1913 Females 495 57 Cleveland, Ohio 1903-1912 By Organs and Parts, according to Sex 496 58 Columbus, Ohio 1900-1913 Persons 496 59 Dayton, Ohio 1871-1913 Persons 497 60 Dayton, Ohio 1876-1908 Males 498 61 Dayton, Ohio 1876-1908 Females 499 62 Denver, Colo 1892-1913 Persons 500 63 Denver, Colo 1905-1913 By Sex 500 64 Denver, Colo 1905-1912 By Organs and Parts, according to Sex 501 65 Detroit, Mich 1883-1913 Persons 501 66 Hartford, Conn 1881-1913 Persons 502 67 Hartford, Conn 1886-1913 Males 503 68 Hartford, Conn 1886-1913 Females 503 69 Hoboken, N. J 1880-1913 Persons 504 70 Hoboken, N. J 1902-1913 By Sex 504 71 Indianapohs, Ind 1900-1913 Persons 505 72 Indianapohs, Ind 1906-1913 By Sex 505 73 Jersey City, N. J 1879-1913 Persons 506 74 Jersey City, N. J 1902-1913 By Sex 507 75 Kansas City, Mo 1900-1913 Persons 507 76 Los Angeles, Cal 1900-1913 Persons 508 77 Louisville, Ky 1890-1913 Persons 508 78 Memphis, Tenn 1891-1914 Persons 509 79 Memphis, Tenn 1891-1914 White 509 80 Memphis, Tenn 1891-1914 Colored 510 81 Milwaukee, Wis 1894-1913 Persons 510 82 Milwaukee, Wis 1898-1913 Males 511 451 APPENDIX F {PART II) Table City Period Title Page 83 Milwaukee, Wis 1898-1913 Females 511 84 Minneapolis, Minn 1889-1913 Persons 512 85 Minneapolis, Minn 1908-1912 By Organs and Parts, according to Sex 512 86 Minneapolis, Minn 1908-1912 By Organs and Parts, according to Age 513 87 Nashville, Tenn 1879-1914 Persons 513 88 Nashville, Tenn 1885-1913 Males 514 89 Nashville, Tenn 1885-1913 Females 514 90 Nashville, Tenn 1885-1914 Wliite 515 91 Nashville, Tenn 1885-1914 Colored 516 92 Nashville, Tenn 1903-1912 By Organs and Parts, according to Sex ..... 516 93 Newark,N.J 1859-1913 Persons 517 94 Newark, N. J 1902-1913 By Sex 518 95 New Haven, Conn 1880-1913 Persons 518 96 New Haven, Conn 1880-1913 Males 519 97 New Haven, Conn 1880-1913 Females 520 98 New Orleans, La 1871-1914 Persons 521 99 New Orleans, La 1877-1914 ^Vhite 522 100 New Orleans, La 1877-1914 Colored 523 101 New Orleans, La 1901-1913 By Sex 524 102 New Orleans, La 1904-1913 By Organs and Parts, according to Race. ... 525 103 New Orleans, La 1904-1913 By Organs and Parts, according to Sex and Race 525 104 New Orleans, La., Charity Hospi- tal 1908-1912 By Organs and Parts, White 526 105 New Orleans, La., Charity Hospi- tal 1908-1912 By Organs and Parts, Colored 529 106 Greater New York, N. Y 1891-1914 Persons 532 107 Greater New York, N. Y 1891-1913 Males 532 108 Greater New York, N. Y 1891-1913 Females 533 109 Greater New York, N. Y 1893-1912 By Age 533 110 Greater New York, N. Y 1893-1912 By Age, Males 534 111 Greater New York, N. Y 1893-1912 By Age, Females 534 112 Greater New York, N. Y 1903-1912 Buccal Cavity, ac- cording to Sex 535 113 Greater New York, N. Y 1903-1912 Stomach and Liver, according to Sex 535 114 Greater New York, N. Y 1903-1912 Peritoneum,Intestines and Rectum, accord- ing to Sex 536 115 Greater New York, N. Y 1903-1912 Female Generative Organs 536 116 Greater New York, N. Y 1903-1912 Female Breast 536 117 Greater New York, N. Y 1903-1912 Skin, according to Sex 537 118 Greater New York, N. Y 1903-1912 Other or Not Specified Organs, according to Sex 537 452 APPENDIX F {PART II) Table City Period Title Page 119 Greater New York, N. Y 1903-1907—1908-1912 By Organs and Parts 538 120 Greater New York, N. Y 1903-1907—1908-1912 By Organs and Parts, according to Sex. . . . 538 121 Greater New York, N. Y 1903-1912 By Boroughs, accord- ing to Sex 539 122 Manhattan and Bronx, N. Y. C . . 1871-1913 Persons 540 123 Manhattan and Bronx, N. Y. C . . 1871-1913 Males 541 124 Manhattan and Bronx, N. Y, C . . 1871-1913 Females 542 125 Omaha, Neb 1900-1913 Persons 542 126 Philadelphia, Pa 1861-1914 Persons 543 127 Philadelphia, Pa 1861-1914 Males 544 128 Philadelphia, Pa 1861-1914 Females 545 129 Philadelphia, Pa 1878-1903* By Organs and Parts, according to Sex 546 130 Philadelphia, Pa 1891-1902—1903-1912 By Organs and Parts 546 131 Philadelphia, Pa 1881-1912 Buccal Cavity, ac- cording to Age 547 132 Philadelphia, Pa 1881-1912 Stomach and Liver, according to Age 547 133 Philadelphia, Pa 1881-1912 Peritoneum,Intestines and Rectum, accord- ing to Age 548 134 Philadelphia, Pa 1881-1912 Generative Organs, according to Age 548 135 Philadelphia, Pa 1881-1912 Breast, according to Age 549 136 Philadelphia, Pa 1881-1912 Skin, according to Age 549 137 Philadelphia, Pa 1881-1912 Other or Not Specified Organs, according to Age 550 138 Philadelphia, Pa 1881-1912 According to Age 550 139 Pittsburgh, Pa 1888-1913 Persons 551 140 Pittsburgh, Pa 1888-1899—1910-1913 Males 551 141 Pittsburgh, Pa 1888-1899—1910-1913 Females. 552 142 Pittsburgh, Pa 1893-1902—1903-1912 According to Age 552 143 Pittsburgh, Pa 1888-1899 By Organs and Parts, according to Age 553 144 Pittsburgh, Pa 1888-1899 By Organs and Parts, according to Sex 553 145 Pittsburgh, Pa 1910-1913 By Organs and Parts, according to Sex 554 146 Pittsburgh, Pa 1888-1899—1910-1913 By Organs and Parts, according to Sex .... 554 147 Providence, R. 1 1881-1914 Persons 555 148 Providence, R. 1 1881-1914 Males 556 149 Providence, R. 1 1881-1914 Females 557 150 Providence, R. 1 1903-1912 By Organs and Parts, according to Sex 557 151 Richmond, Va 1879-1914 Persons 558 152 Richmond, Va 1882-1913 Males 559 153 Richmond, Va 1882-1913 Females 559 154 Richmond, Va 1879-1914 White 560 •Excluding 1897-1898. 453 APPENDIX F {PART II) Table City Period Title Page 155 Richmond, Va 1879-1914 Colored 560 156 Richmond, Va 1903-1912 By Organs and Parts, according to Sex 561 157 Rochester, N. Y 1891-1913 Persons 561 158 Rochester, N. Y 1900-1913 BySex 562 159 San Francisco, Cal 1884-1913 Persons 562 160 San Francisco, Cal 1884-1913 Males 563 161 San Francisco, Cal 1884-1913 Females 564 162 San Francisco, Cal 1906-1913 By Organs and Parts, according to Sex 564 163 San Francisco, Cal 1906-1911 By Age, according to Sex 565 164 Savannah, Ga 1881-1914 Persons 565 165 Savannah, Ga 1881-1914 White 566 166 Savannah, Ga 1881-1914 Colored 567 167 Seattle, Wash 1899-1914 Persons 567 168 Seattle, Wash 1901-1912 By Organs and Parts. 568 169 Springfield, Mass 1890-1913 Persons 568 170 Springfield, Mass 1891-1913 Males 569 171 Springfield, Mass 1891-1913 Females 569 172 Springfield, Mass 1908-1912 By Organs and Parts, according to Sex 570 173 St. Louis, Mo. 1881-1913 Persons 570 174 St. Louis, Mo 1887-1913 Males 571 175 St. Louis, Mo 1887-1913 Females 571 176 St. Paul, Minn 1885-1913 Persons 572 177 District of Columbia 1879-1914 Persons 573 178 District of Columbia 1879-1913 Males 574 179 District of Columbia 1879-1913 Females 575 180 District of Columbia 1882-1914 White 576 181 District of Columbia 1882-1914 Colored 577 182 District of Columbia 1901-1910 By Organs and Parts, according to Age, White Males 578 183 District of Columbia 1901-1910 By Organs and Parts, according to Age, White Females 579 184 District of Columbia 1901-1910 By Organs and Parts, according to Age, Colored Males 580 185 District of Columbia 1901-1910 By Organs and Parts, according to Age, Colored Females ... . 581 454 APPENDIX F {PART II) Table 1 Mortality from Cancer in the State of Connecticut 1875-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1875 580,075 204 35.2 1901 931,055 635 68.2 1902 951,949 624 65.5 1876 588,600 175 29.7 1903 972,844 721 74.1 1877 597,125 219 36.7 1904 993,739 669 67.3 1878 605,650 245 40.5 1905 1,014,634 747 73.6 1879 614,175 209 34.0 1880 622,700 226 36.3 35.5 1901-1905 1906 4,864,221 1,035,529 3,396 809 69.8 1876-1880 3,028,250 1,074 78.1 1907 1,056,424 809 76.6 1881 635,055 269 42.4 1908 1,077,319 791 73.4 1882 647,410 248 38.3 1909 1,098,214 876 79.8 1883 659,766 305 46.2 1910 1,119,109 896 80.1 1884 672,122 312 46.4 1885 684,478 288 42.1 43.1 1906-1910 1911 5,386,595 1,140,003 4,181 890 77.6 1881-1885 3,298,831 1,422 78.1 1912 1,160,898 937 80,7 1886 696,834 280 40.2 1913 1,181,793 1,000 84,6 1887 709,190 316 44.6 1888 721,546 348 48.2 Source: Bureau of Vital Statistics of 1889 733,902 324 44.1 the State of Connecticul ., Annual Registra- 1890 746,258 361 48.4 45.2 tion Reports. 1886-1890 3,607,730 1,629 1891 762,474 417 54.7 1892 778,690 366 47.0 1893 794,906 405 50.9 1894 811,122 416 51.3 1895 827,338 471 56.9 52.2 1891-1895 3,974,530 2,075 1896 843,554 459 54.4 1897 859,770 514 59.8 1898 . 875,986 517 59.0 1899 892,203 569 63.8 1900 910,161 608 66.8 60.9 1896-1900 4,381,674 2,667 455 APPENDIX F {PART II) Table 2 Mortality from Cancer in the State of Connecticut, Males 1879-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1879 301,437 60 19.9 1906 521,078 314 60.3 1880 • 305,808 68 22.2 1907 532,226 1908 543,400 299 56.2 292 53.7 1881 312,130 91 29.2 1909 554,598 316 57.0 1882 318,461 66 20.7 1910 565,822 328 58.0 1883 1884 324,803 331,155 95 101 29.2 30.5 27.4 1906-1910 2,717,124 1911 577,070 1,549 57.0 1881-1884 1,286,549 353 294 50.9 1912 588,343 357 60.7 1886 343,888 83 24.1 1913 599,639 377 62.9 1887 350,269 108 30.8 1888 356,660 106 29.7 Source: Bureau of Vital Statistics of 1889 363,061 112 30.8 the State of Connecticut, Annual Registra- 1890 369,547 116 31.4 " 29.4 tion Reports. 1886-1890 1,783,425 525 1891 377.882 142 37.6 1892 386,308 102 26.4 1893 394,750 131 33.2 1894 403,209 137 34.0 1895 411,683 134 32.5 32.7 1891-1895 1,973,832 646 1896 420,174 159 37.8 1897 428,681 172 40.1 1898 437,205 169 38.7 1899 445,745 169 37.9 1900 455,172 217 47.7 40.5 1896-1900 2,186.977 886 1901 466,086 243 52.1 1902 477,022 207 43.4 1903 487,979 226 46.3 1904 498,956 219 43.9 1905 509,955 270 52.9 47.7 1901-1905 2,439,998 1,165 456 APPENDIX F {PART II) Table 3 Mortality from Cancer in the State of Connecticut, Females 1879-1913 Year 1879 1880 1881 1882 1883 188J. Population 312,738 316,892 322,925 328,949 334,963 340,967 1881-1884 1,327,804 1886 1887 1888 1889 1890 352,946 358,921 364,886 370,841 376,711 Deaths from Cancer 149 158 178 182 210 211 781 197 208 242 212 245 Rate per 100,000 Population 47.6 49.9 55.1 55.3 62.7 61.9 58.8 55.8 58.0 66.3 57.2 65.0 1886-1890 1,824,305 1,104 60.5 1891 384,592 275 71.5 1892 392,382 264 67.3 1893 400,156 274 68.5 1894 407,913 279 68.4 1895 415,655 337 81.1 1891-1895 2,000,698 1,429 71.4 1896 423,380 300 70.9 1897 431,089 342 79.3 1898 438,781 348 79.3 1899 446,458 400 89.6 1900 454,989 391 85.9 1896-1900 2,194,697 1,781 81.2 1901 464,969 392 84.3 1902 474,927 417 87.8 1903 484,865 495 102.1 1904 494,783 450 90.9 1905 504,679 477 94.5 1901-1905 2,424,223 2,231 92.0 Year 1906 1907 1908 1909 1910 Population 514,451 524,198 533,919 543,616 553,287 Deaths from Cancer 495 510 499 560 568 1906-1910 2,669,471 2,632 1911 1912 1913 562,933 572,555 582,154 596 580 623 Rate per 100,000 Population 96.2 97.3 93.5 103.0 102.7 98.6 105.9 101.3 107.0 Source: Bureau of Vital Statistics of the State of Connecticut, Annual Registra- tion Reports. 457 APPENDIX F (PART II) Table 4 Mortality from Cancer in the State of Maine 1892-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1892 667,762 404 60.5 1906 723,976 617 85.2 1893 671,100 433 64.5 1907 728,827 737 101.1 1894 674,438 474 70.3 1908 733,678 710 96.8 1895 677,776 480 70.8 1909 738,530 727 98.4 1910 743,382 762 102.5 1892-1895 2,691,076 1,791 66.6 1906-1910 3,668,393 3,553 96.9 1896 681,114 518 76.1 1897 684,452 463 67.6 1911 748,233 738 98.6 1898 687,790 531 77.2 1912 753,085 828 109.9 1899 691,128 541 78.3 1913 757,936 838 110.6 1900 694,870 526 75.7 Source: Annual Reports upon the 1896-1900 3,439.354 2,579 75.0 Births, Marriages, Divorces and Deaths in the State of Maine. 1901 699,721 570 81.5 1902 704,572 615 87.3 1903 709,423 598 84.3 1904 714,274 611 85.5 1905 719,125 662 92.1 86.2 1901-1905 3,547,115 3,056 Table 5 Mortality from Cancer in the State of Maine, Males 1892-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1892 336,085 150 44.6 1906 366.911 238 64.9 1893 337,899 170 50.3 1907 369,588 C66 72.0 1894 339,714 177 52.1 1908 372,268 243 65.3 1895 341,531 173 50.7 1909 374,952 271 72.3 1910 377,564 260 68 9 1892-1895 1,355,229 670 49.4 1906-1910 1,861,283 1.278 68.7 1896 343,350 185 53.9 1897 345,169 188 54.5 1911 380,177 254 66.8 1898 347,059 197 56.8 1912 382.868 261 68.2 1899 348,951 179 51.3 1913 385,637 290 75.2 1900 351,187 188 53.5 Source: Annual Reports upon the 1896-1900 1,735,716 937 54.0 Births, Marriages, Divorces and Deaths in the State of Maine. 1901 353,779 199 56.2 1902 356,373 224 62.9 1903 358,968 210 58.5 1904 361,565 245 67.8 1905 364,237 238 65.3 62.2 1901-1905 1,794,922 1,116 458 APPENDIX F {PART II) Table 6 Mortality from Cancer in the State of Maine, Females 1892-1913 Deaths Rate per Year Population from 100,000 Cancer Population 1892 331,677 254 76.6 1893 333,201 263 78.9 1894 334,724 297 88.7 1895 336,245 1,335,847 307 91.3 1892-1895 1,121 83.9 1896 337,764 333 98.6 1897 339,283 275 81.1 1898 340,731 334 98.0 1899 342,177 362 105.8 1900 343,683 338 98.3 1896-1900 1,703,638 1,642 96.4 1901 345,942 371 107.2 1902 348,199 391 112.3 1903 350,455 388 110.7 1904 352,709 366 103.8 1905 354,888 424 119.5 1901-1905 1,752,193 1,940 110.7 1906 357,065 379 106.1 1907 359,239 471 131.1 1908 361,410 467 129.2 1909 363,578 456 125.4" 1910 365,818 502 2,275 137.2 1906-1910 1,807,110 125.9 1911 368,056 484 131.5 1912 370,217 567 153.2 1913 372,299 548 147.2 Source: Annual Reports upon the Births, Marriages, Divorces and Deaths in the State of Maine. 459 APPENDIX F (PART 11) Table 7 Mortality from Cancer in the State of Massachusetts 1856-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1856 1,151,461 217 18.8 1886 1,998,174 1,104 55.3 1857 1,170,864 242 20.7 1887 2,055,821 1,174 57.1 1858 1,190,584 289 24.3 1888 2,115,131 1,275 60.3 1859 1,210,657 306 25.3 1889 2,176,153 1,325 60.9 1860 1,231,066 535* 27.2 23.3 1890 1886-1890 2,238,943 1,387 61.9 1856-1860 5,954,632 1,389 10,584,222 6,265 59.2 1861 1,238,177 336 27.1 1891 2,288,911 1,395 60.9 1862 1,245,328 319 25.6 1892 2,339,994 1,402 59.9 1863 1,252,521 324 25.9 1893 2,392,217 1,533 64.1 1864 1,259,756 3^0 26.2 1894 2,445,605 1,568 64.1 1865 1,267,031 375 29.6 26.9 1895 1891-1895 2,500,183 1,749 70.0 1861-1865 6,262,813 1,684 11,966,910 7,647 63.9 1866 1,302,992 416 31.9 1896 2,558,437 1,798 70.3 1867 1,339,976 395 29.5 1897 2,618,048 1,739 66.4 1868 1,378,010 445 32.3 1898 2,679,048 1,907 71.2 1869 1,417,125 492 34.7 1899 2,741,470 1,838 67.0 1870 1,457,351 516 35.4 32.8 1900 1896-1900 2,805,346 1,998 71.2 1866-1870 6,895,454 2,264 13,402,349 9,280 69.2 1871 1,494,337 551 36.9 1901 2,845,012 2,080 73.1 1872 1,532,260 542 35.4 1902 2,884,679 2,141 74.2 1873 1,571,142 611 38.9 1903 2,924,346 2,243 76.7 1874 1,611,016 585 36.3 1904 2,964,013 2,351 79.3 1875 1,651,912 593 35.9 36.7 1905 1901-1905 3,015,873 2,501 82.9 1871-1875 7,860,667 2,882 14,633,923 11,316 77.3 1876 1,677,351 657 39.2 1906 3,089,029 2,603 84.3 1877 1,703,182 646 37.9 1907 3,162,186 2,744 86.8 1878 1,729,412 807 46.7 1908 3,235,343 2,814 87.0 1879 1,756,043 862 49.1 1909 3,308,500 2,871 86.8 1880 1,783,085 928 52.0 45.1 1910 1906-1910 3,381,657 3,028 89.5 1876-1880 8,649,073 3,900 16,176,715 14,060 86.9 1881 1,813,818 949 52.3 1911 3,454,813 3,199 92.6 1882 1,845,086 987 53.5 1912 3,491,888 3,282 94.0 1883 1,876,895 1,026 54.7 1913 3,548,705 3,526 99.4 1884 1,909,810 1,060 55.5 1885 1,942,141 1,087 56.0 Source: Annual Reports of Births, 54.4 Marriages and Deaths in Massa *Vital Statistics of Massachusetts, 185 chusetts. 1881-1885 9,387.750 5,109 6-1895. 460 APPENDIX F {PART II) Table 8 Mortality from Cancer in the State of Massachusetts, Males 1856-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1856 559,034 72 12.9 1886 961,921 334 34.7 1857 568,220 78 13.7 1887 991,934 358 36.1 1858 577,552 98 17.0 1888 1,022,877 411 40.2 1859 587,048 99 16.9 1889 1,054,781 413 39.2 1890 1,087,679 414 38.1 1856-1859 2,291,854 347 15.1 1886-1890 5,119,192 1,930 37.7 1861 597,792 100 16.7 1862 598,878 103 17.2 1891 1,111,953 436 39.2 1863 599,958 107 17.8 1892 1,136,769 466 41.0 1864 601,030 112 18.6 1893 1,162,139 502 43.2 1865 602,010 124 20.6 1894 1,188,075 519 43.7 1895 1,214,589 535 44.0 1861-1865 2,999,668 546 18.2 1891-1895 5,813,525 2,458 42.3 1866 621,006 109 17.6 1867 640,643 136 21.2 1896 1,243,656 594 47.8 1868 661,031 146 22.1 1897 1,273,419 565 44.4 1869 682,062 146 21.4 1898 1,303,893 598 45.9 1870 703,779 184 26.1 1899 1,335,370 598 44.8 1900 1,367,606 684 50.0 1866-1870 3,308,521 721 21.8 1896-1900 6,523,944 3,039 46.6 1871 721,615 166 23.0 1872 739,162 182 24.6 1901 1,386,659 704 50.8 1873 757,133 198 26.2 1902 1,405,416 686 48.8 1874 775,643 190 24.5 1903 1,424,157 741 52.0 1875 794,404 173 21.8 1904 1,442,882 808 56.0 1905 1,467,524 843 57.4 1871-1875 3,787,857 909 24.0 1901-1905 7,126,638 3,782 53.1 1876 806,974 202 25.0 1877 819,571 176 21.5 1906 1,506,519 977 64.9 1878 832,366 260 31.2 1907 1,545,360 ■ 932 60.3 1879 1908 1,584,347 966 61.0 1880 858,565 306 35.6 1909 1,623,481 991 61.0 1910 1,662,761 1,065 64.1 1876-1880 3,317,466 944 28.5 1906-1910 7,922,468 4,931 62.2 1881 872,991 338 38.7 1882 887,671 303 34.1 1911 1,702,180 1,177 69.1 1883 902,599 325 36.0 1912 1,723,946 1,115 64.7 1884 917,855 351 38.2 1913 1,755,544 1,282 73.0 1885 932,810 332 35.6 Source: Annual Reports of Births, 1881-1885 4,513,926 1,649 36.5 Marriages and Deaths in Massachusetts. 461 APPENDIX F {PART II) Table 9 Mortality from Cancer in the State of Massachusetts, Females 1856-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1856 592,427 145 24.5 1886 1,036,253 770 74.3 1857 602,644 164 27.2 1887 1,063,887 816 76.7 1858 613,032 191 31.2 1888 1,092,254 864 79.1 1859 623,609 207 33.2 1889 1,121,372 912 81.3 1890 1,151,264 973 84.5 1856-1859 2,431,712 707 29.1 1886-1890 5,465,030 4,335 79.3 1861 640,385 236 36.9 1862 646,450 216 33.4 1891 1,176,958 959 81.5 1863 652,563 217 33.3 1892 1,203,225 936 77.8 1864 658,726 218 33.1 1893 1,230,078 1,031 83.8 1865 665,021 251 37.7 1894 1,257,530 1,049 83.4 1895 1,285,594 1,214 94.4 1861-1865 3,263,145 1,138 34.9 1891-1895 6,153,385 5,189 84.3 1866 681,986 307 45.0 1867 699,333 259 37.0 1896 1,314,781 1,204 91.6 1868 716,979 299 41.7 1897 1,344,629 1,174 87.3 1869 735,063 346 47.1 1898 1,375,155 1,309 95.2 1870 753,572 332 44.1 1899 1,406,100 1,240 88.2 1900 1,437,740 1,314 91.4 1866-1870 3,586,933 1,543 43.0 1896-1900 6,878,405 6,241 90.7 1871 772,722 385 49.8 1872 793,098 360 45.4 1901 1,458,353 1,376 94.4 1873 814,009 413 50.7 1902 1,479,263 1,455 93.4 1874 835,473 395 47.3 1903 1,500,189 1,502 100.1 1875 857,508 420 49.0 1904 1,521,131 1,543 101.4 1905 1,548,349 1,658 107.1 1871-1875 4,072,810 1,973 48.4 1901-1905 7,507,285 7,534 100.4 1876 870,377 455 52.3 1877 883,611 470 53.2 1906 1,582,510 1,626 102.7 1878 897,04.6 547 61.0 1907 1,616,826 1,812 112.1 1879 1908 1,650,996 1,848 111.9 1880 924,530 622 67.3 1909 1,685,019 1,880 111.6 1910 1,718,896 1,963 114.2 1876-1880 3,575,564 2,094 58.6 1906-1910 8,254,247 9,129 110.6 1881 940,827 611 64.9 1882 957,415 684 71.4 1911 1,752,627 2,022 115.4 1883 974,296 701 71.9 1912 1,767,942 2,167 122.6 1884 991,955 709 71.5 1913 1,793,161 2,244 125.1 1885 1,009,331 755 74.8 fimirpp* AtitiuqI ■Rf.r.nrta nf Rlrtlna 1881-1885 4,873,824 3,460 71.0 Marriages and Deaths in Massachusetts. 462 APPENDIX F {PART 11) Table 10 Table 11 Mortality from Cancer in the State Mortality from Cancer in the State of New Hampshire of New Hamps hire, Males 1884-1913 Rate per 1887-1913 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1884 358,806 213 59.4 1887 181,738 70 38.5 1885 361,760 213 58.9 1888 183,347 66 36.0 1889 184,957 70 37.8 1886 364,714 206 56.5 1890 186,571 86 46.1 1887 367,668 218 59.3 1888 370,622 203 54.8 1887-1890 736,613 292 39.6 1889 373,576 213 57.0 1890 376,530 276 73.3 1891 188,459 74 39.3 1892 1893 190,351 192,246 69 106 36.2 55.1 1886-1890 1,853,110 1,116 60.2 1894 194,143 80 41.2 1891 380,035 222 58.4 1895 196,044 100 51.0 1892 383,540 235 61.3 1893 387,046 283 73.1 1891-1895 961,243 429 44.6 1894 390,552 230 58.9 1895 394,058 266 67.5 1896 197,907 84 42.4 1897 1898 199,773 201,641 87 102 43.5 50.6 1891-1895 1,935,231 1,236 63.9 1899 203,510 89 43.7 1896 397,564 275 69.2 1900 205,382 88 42.8 1897 401,070 265 66.1 1898 404,576 305 75.4 1896-1900 1,008,213 450 44.6 1899 408,082 279 68.4 1900 411,588 292 70.9 1901 206,587 114 55.2 1902 207,713 120 57.8 1896-1900 2,022,880 1,416 70.0 1903 208,841 110 52.7 1904 209,928 111 52.9 1901 413,670 364 88.0 1905 211,016 126 59.7 1902 415,592 341 82.1 1903 417,514 314 75.2 1901-1905 1,044,085 581 55.6 1904 419,436 326 77.7 1905 421,358 344 81.6 1906 212,106 109 51.4 1907 213,197 123 57.7 1901-1905 2,087,570 1,689 80.9 1908 214,289 126 58.8 1909 215,383 131 60.8 1906 423,280 354 83.6 1910 216,477 155 71.6 1907 425,203 386 90.8 1908 427,126 373 87.3 1906-1910 1,071,452 644 60.1 1909 429,049 383 89.3 1910 430,972 406 94.2 1911 217,573 138 63.4 1912 218,670 176 80.5 1906-1910 2,135,630 1,902 89.1 1913 219,767 164 74.6 1911 432,894 408 94.2 Source : Reports relating to the Regis- 1912 434,818 453 104.2 tration and Return o1 Births, Marriages, 1913 436,742 453 103.7 Divorces and Deaths i n New Hampshire. Source: Reports relating to the Regis- tration and Return of Births, Marriages, Divorces and Deaths in New Hampshire. 463 APPENDIX V {PART II) Table 12 Mortality from Cancer in the State of New Hampshire, Females 1887-1913 Deaths Rate per Year Population from 100,000 Cancer Population 1887 185,930 148 79.6 1888 187,275 137 73.2 1889 188,619 143 75.8 1890 189,959 190 100.0 1887-1890 751,783 618 82.2 1891 191,576 148 77.3 1892 193,189 166 85.9 1893 194,800 177 90.9 1894 , 196,409 150 76.4 1895 198,014 166 83.8 1891-1895 973,988 807 82.9 1896 199,657 191 95.7 1897 201,297 178 88.4 1898 202,935 203 100.0 1899 204,572 190 92.9 1900 206,206 204 98.9 1896-1900 1.014,667 966 95.2 1901 207,083 250 120.7 1902 207,879 221 106.3 1903 208.673 204 97.8 1904 209,508 215 102.6 1905 210,342 218 103.6 1901-1905 1,043,485 1,108 106.2 1906 211,174 245 116.0 1907 212,006 263 124.1 1908 212,837 247 116.1 1909 213,666 252 117.9 1910 214,495 251 117.0 1906-1910 1,064,178 1,258 118.2 1911 215,321 270 125.4 1912 216,148 277 128.2 1913 216,975 289 133.2 Source: Reports relating to the Registration and Return of Births, Marriages, Divorces and Deaths in New Hamp- shire. 464 APPENDIX F (PART 11) Table 13 Mortality from Cancer in the State of New Jersey 1879-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1879 1,109,009 378 34.1 1901 1,935,763 1,042 53.8 1880 1,131,116 425 37.6 1902 1,987,858 1,031 51.9 1903 2,039,953 1,132 55.5 1881 1,160,499 451 38.9 1904 2,092,048 1,125 53.8 1882 1883 1,189,882 1,219,265 402 461 33.8 37.8 1905 2,150,861 1,282 59.6 1884 1,248,649 484 38.8 1901-1905 10,206,483 5,612 55.0 1885 1,278,033 498 39.0 1906 2,231,481 2,312,101 1,389 1,466 62.2 1881-1885 6,096.328 2,296 37.7 1907 63!4 1908 2,392,721 1,535 64.2 1886 1,311,413 546 41.6 1909 2,473,342 1,663 67.2 1887 1888 1,344,793 1,378,173 574 612 42.7 44.4 1910 2,553,963 1,838 72.0 1889 1,411,553 579 41.0 1906-1910 11,963,608 7,891 66.0 1890 1,444,933 640 44.3 1911 2,634,583 2,683,309 1,942 1,984 73.7 1886-1890 6,890,865 2,951 42.8 1912 73.9 1913 2,749,486 2,120 77.1 1891 1,490,567 642 43.1 1892 1,536,201 688 44.8 Source: Annual Reports of the Board 1893 1,581,836 723 45.7 of Health of the State of New Jersey. 1894 1,627,471 731 44.9 1895 1,673,106 770 46.0 44.9 1891-1895 7,909,181 3,554 1896 1,715,218 811 47.3 1897 1,757,330 857 48.8 1898 1,799,443 852 47.3 1899 1,841,556 946 51.4 1900 1,883,669 921 48.9 48.8 1896-1900 8,997,216 4,387 465 APPENDIX F {PART II) Table 14 Mortality from Cancer in the State of New York 1885-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1885 6,543,021 1,887 34.0 1906 8,299,820 6,169 74.3 1907 8,514,447 6,420 75.4 1886 5,635,051 2,050 36.4 1908 8,729,074 6,554 75.1 1887 5,723,356 2,363 41.3 1909 8,943,701 7,060 78.9 1888 5,814,855 2,497 42.9 1910 9,158,328 7,522 82.1 1889 5,906,354 2,638 44.7 1890 5,997,853 2,868 47.8 42.7 1906-1910 1911 43,645,370 9,372,954 33,725 7,970 77.3 1886-1890 29,077,469 12,416 85.0 1912 9,526,146 8,250 86.6 1891 6,258,259 3,028 48.4 1913 9,712,954 8,536 87.9 1892 6,513,343 3,152 48.4 1914 9,838,328 8,830 89.8 1893 6,607,787 3,232 48.9 1894 6,702,230 3,305 49.3 Source: Annual Reports of the State 1895 6,796,674 3,554 52.3 49.5 Department of Health of New ^ ifork. 1891-1895 32,878,293 16,271 1896 6,891,118 3,789 55.0 1897 6,985,562 4,131 59.1 1898 7,080,006 4,375 61.8 1899 7,174,450 4,535 63.2 1900 7,268,894 4,871 67.0 61.3 1896-1900 35,400,030 21,701 1901 7,428,576 5,033 67.8 1902 7,588,259 4,989 65.7 1903 7,747,942 5,456 70.4 1904 7,907,625 5,697 72.0 1905 8,085,194 6,055 74.9 70.3 1901-1905 38,757,596 27,230 406 APPENDIX F (PART II) Table 15 Mortality from Cancer in the State of Rhode Island 1871-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1871 225,530 66 29.3 1901 438,861 319 72.7 1872 233,707 95 40.6 1902 449,166 359 79.9 1873 241,884 ■ 106 43.8 1903 459,471 350 76.2 1874 250,061 87 34.8 1904 469,776 401 85.4 1875 258,239 95 36.8 37.1 1905 1901-1905 481,150 383 79.6 1871-1875 1,209,421 449 2,298,424 1,812 78.8 1876 261,897 106 40.5 1906 493,976 377 76.3 1877 265,555 135 50.8 1907 506,802 451 89.0 1878 269,213 119 44.2 1908 519,628 418 80.4 1879 272,872 125 45.8 1909 532,455 461 86.6 1880 276,531 125 45.2 45.3 1910 1906-1910 545,282 474 86.9 1876-1880 1,346,068 610 2,598,143 2,181 83.9 1881 282,081 145 51.4 1911 558,108 486 87.1 1882 287,631 132 45.9 1912 568,114 506 89.1 1883 293,182 169 57.6 1913 579,665 534 92.1 1884 298,733 156 52.2 1885 304,284 193 63.4 Source: Annual Reports relating to Registry and Return of Births, Marriages, 1881-1885 1,465,911 795 54.2 and Deaths , and of Divorce, in the State of Rhode Island. 1912-1913, United States 1886 312,528 162 51.8 Mortality Statistics. 1887 320,772 159 49.6 1888 329,016 193 58.7 1889 337,261 189 56.0 1890 345,506 165 47.8 52.8 1886-1890 1,645,083 868 1891 353,356 177 50.1 1892 361,206 181 50.1 1893 369,056 205 55.5 1894 376,907 216 57.3 1895 384,758 240 62.4 55.2 1891-1895 1,845,283 1,019 1896 393,517 238 60.5 1897 402,276 271 67.4 1898 411,036 293 71.3 1899 419,796 300 71.5 1900 428,556 303 70.7 68.4 1896-1900 2,055,181 1,405 467 APPENDIX F (PART II) Table 16 Mortality from Cancer in the State of Rhode Island, Males 1871-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1871 108,705 25 23.0 1901 215,876 101 46.8 1872 112,623 26 23.1 1902 221,259 129 58.3 1873 116,540 45 38.6 1903 226,657 121 63.4 1874 120,454 23 19.1 1904 232,069 130 66.0 1875 124,368 24 19.3 24.5 1905 1901-1905 238,025 128 609 63.8 1871-1875 582,690 143 1,133,886 53.7 1876 126,103 27 21.4 1906 244,716 126 61.6 1877 127,838 29 22.7 1907 251,424 143 66.9 1878 129,572 38 29.3 1908 258,151 144 55.8 1879 131,306 39 29.7 1909 264,896 158 69.6 1880 133,039 45 33.8 27.5 1910 1906-1910 271,659 163 60.0 1876-1880 647,858 178 1,290,846 734 66.9 1881 135,850 40 29.4 1911 ■ 278.440 173 62.1 1882 138,667 40 28.8 1912 283,830 173 61.0 1883 141,490 51 36.0 1913 289,671 185 63.9 1884 144,169 39 27.1 1885 147,152 52 35.3 Source: Annual Reports relating to Registry and Return of Births, ] l/Tq ■PT'I a (TPC VXcll 1 id^ ca. 1881-1885 707,328 222 31.4 and Deaths, and of Divorce, in the State of Rhode Island. 1912-1913, United States 1886 151,295 42 27.8 Mortality Statistics. 1887 155,446 49 31.5 1888 159,639 67 42.0 1889 163,841 65 39.7 1890 168,020 56 33.3 35.0 1886-1890 798,241 279 1891 171,978 48 27.9 1892 175,980 53 30.1 1893 179,989 54 30.0 1894 184,006 68 37.0 1895 188,031 77 41.0 1891-1895 1896 1897 1898 1899 1900 899,984 192,509 196,995 201,490 205,994 210,507 300 69 86 88 98 102 33.3 35.8 43.7 43.7 47.6 48.5 44.0 1896-1900 1,007,495 443 408 APPENDIX F (PART II) Table 17 Mortality from Cancer in the State of Rhode Island, Females 1871-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1871 116,825 41 35.1 1901 222,985 218 97.8 1872 121,084 69 57.0 1902 227,907 230 100.9 1873 125,344 61 48.7 1903 232,814 229 98.4 1874 129,607 64 49.4 1904 237,707 271 114.0 1875 133,871 71 53.0 48.8 1905 1901-1905 243,125 255 104.9 1871-1875 626,731 306 1,164,538 1,203 103.3 1876 135,794 79 58.2 1906 249,260 251 100.7 1877 137,717 106 77.0 1907 255,378 308 120.6 1878 139,641 81 58.0 1908 261,477 274 104.8 1879 141,566 86 60.7 1909 267,559 303 113.2 1880 143,492 80 55.8 61.9 1910 1906-1910 273,623 311 113.7 1876-1880 698,210 432 1,307,297 1,447 110.7 1881 146,231 105 71.8 1911 279,668 313 111.9 1882 148,964 92 61.8 1912 284,284 333 117.1 1883 151,692 118 77.8 1913 289,994 349 120.3 1884 154,564 117 75.7 1885 157,132 141 89.7 Source: Annual Reports relating to Registry and Return of Births, Marriages, 1881-1885 758,583 573 75.5 and Deaths , and of Divorce, in the State of Rhode Island. 1912-1913, United States 1886 161,233 120 74.4 Mortality Statistics. 1887 165,326 110 66.5 1888 169,377 126 74.4 1889 173,420 124 71.5 1890 177,486 109 61.4 69.6 1886-1890 846,842 589 1891 181,378 129 71.1 1892 185,226 128 69.1 1893 189,067 151 79.9 1894 192,901 148 76.7 1895 196,727 163 719 82.9 76.1 1891-1895 945,299 1896 201,008 169 84.1 1897 205,281 185 90.1 1898 209,546 205 97.8 1899 213,802 202 94.5 1900 218,049 201 962 92.2 91.8 1896-1900 1,047,686 469 APPENDIX F {PART II) Table 18 Mortality from Cancer in the State of Vermont 1871-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1871 330,724 149 45.1 1901 344,992 242 70.1 1872 330,897 108 32.6 1902 346,239 245 70.8 1873 331,070 117 35.3 1903 347,486 313 90.1 1874 331,243 117 35.3 1904 348,733 299 85.7 1875 331,416 125 37.7 37.2 1905 349,980 291 83.1 1871-1875 1,655,350 616 1901-1905 1,737,430 1,390 80.0 1876 331,590 174 52.5 1906 351,227 287 81.7 1877 331,764 158 47.6 1907 352,474 337 95.6 1878 331,938 177 53.3 1908 353,721 319 90.2 1879 332,112 155 46.7 1909 354,968 335 94.4 1880 332,286 177 53.3 50.7 1910 356,216 369 103.6 1876-1880 1,659,690 841 1906-1910 1,768,606 1,647 93.1 1881 332,299 147 44.2 1911 357,463 347 97.1 1882 332,312 175 52.7 1912 358,710 396 110.4 1883 332,325 187 56.3 1913 359,957 378 105.0 1884 332,338 174 52.4 1885 332,352 192 57.8 Source: Report to the Legislature of Vermont relating to the Registry and Re- 1881-1885 1,661.626 875 52.7 turns of Births, Marriages, Deaths and Divorces in the State. 1886 332,366 188 56.6 1887 332,380 205 61.7 1888 332,394 188 56.6 1889 332,408 198 59.6 1890 332,422 191 57.5 58.4 1886-1890 1,661,970 970 1891 333,543 181 54.3 1892 334,665 178 53.2 1893 335,787 193 57.5 1894 336,909 192 57.0 1895 338,031 199 58.9 56.2 1891-1895 1,678,935 943 1896 339,153 200 59.0 1897 340,275 207 60.8 ' 1898 341,397 242 70.9 1899 342,519 270 78.8 1900 343,641 291 84.7 70.9 1896-1900 1,706,985 1,210 470 APPENDIX F {PART II) Table 19 Mortality from Cancer in the State of Vermont, Males 1871-1896 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1871 165,792 45 27.1 1886 168,377 80 47.5 1872 165,912 32 19.3 1887 168,616 67 39.7 1873 166.032 48 28.9 1888 168,856 78 46.2 1874 166,151 47 28.3 1889 169,096 68 40.2 1875 166.271 36 21.7 25.1 1890 1886-1890 169,336 77 45.5 1871-1875 830,158 208 844,281 370 43.8 1876 166,392 65 '39.1 1891 169,940 60 35.3 1877 166,512 62 37.2 1892 170,545 52 30.5 1878 166,333 65 39.0 1893 171.151 62 36.2 1879 166,753 66 39.6 1894 171,723 64 37.3 1880 166.874 68 40.7 39.1 1895 1891-1895 172,294 69 40.0 1876-1880 833,164 326 855.653 307 35.9 1881 167,113 50 29.9 1896 172.866 74 42.8 1882 167,352 58 34.7 1883 167,591 62 37.0 Source : Report to the Legislature of 1884 167,831 61 36.3 Vermont relating to the Registry and Re- 1885 168,104 88 52.3 turns of Births. Marriages, Deaths and Divorces in the State. 1881-1885 837,991 319 38.1 Table 20 Mortality from Cancer in the State of Vermont, Females 1871-1896 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1871 164.932 104 63.1 1886 163.989 108 65.9 1872 164,985 76 46.1 1887 163,764 138 84.3 1873 165,038 69 41.8 1888 163,538 110 67.3 1874 165,092 70 42.4 1889 163,312 130 79.6 1875 165,145 89 53.9 49.4 1890 1886-1890 163,086 114 69.9 1871-1875 825,192 408 817,689 600 73.4 1876 165,198 109 66.0 1891 163,603 121 74.0 1877 165,252 96 58.1 1892 164,120 126 76.8 1878 165,305 112 67.8 1893 164,636 131 79.6 1879 165,359 89 53.8 1894 165,186 128 77.5 1880 165,412 109 65.9 62.3 1895 1891-1895 165.737 130 78.4 1876-1880 826,526 515 823,282 636 77.3 1881 165,186 97 58.7 1896 166,287 126 75.8 1882 164,960 117 70.9 1883 164,734 125 75.9 Source: Report to the Legislature of 1884 164,507 113 68.7 Vermont relating to the Registry and Re- 1885 164,248 104 63.3 turns of Births. Marriages. Deaths and Divorces in L the State. 1881-1885 823,635 556 67.5 471 APPENDIX F (PART II) Table 21 Mortality from Cancer in the New England States New York and New Jersey 1886-1913 Deaths Rate per Year Population from 100,000 Cancer Population 1886 10,651,080 4,536 42.6 1887 10,853,980 5,009 46.1 1888 11,061,737 5,316 48.1 1889 11,271,207 5,466 48.5 1890 11,482,445 5,888 51.3 1886-1890 55,320,449 26,215 47.4 1891 11,867,145 6,062 51.1 1892 12,915,401 6,606 51.1 1893 13,139,735 7,007 53.3 1894 13,365,234 7,132 53.4 1895 13,591,924 7,729 56.9 1891-1895 64,879,439 34,536 53.2 1896 13,819,675 8,088 58.5 1897 14,048,783 8,447 60.1 1898 14,279,282 9,022 63.2 1899 14,511,204 9,278 63.9 1900 14,746,725 9,810 66.5 1896-1900 71,405,669 44,645 62.5 1901 15,037,650 10,285 68.4 1902 15,328,314 10,345 67.5 1903 16,618,979 11,127 71.2 1904 15,909,644 11,479 72.2 1905 16,238,175 12,265 75.5 1901-1905 78,132,762 55,501 71.0 1906 16,648,318 12,605 75.7 1907 17,058,464 13,350 78.3 1908 17,468,610 13,514 77.4 1909 17,878,759 14,376 80.4 1910 18,288,909 15,295 83.6 1906-1910 87,343,060 69,140 79.2 1911 18,699,051 15,980 85.5 1912 18,976,968 16,640 87.7 1913 19,327,238 17,385 90.0 Note: Maine ! not included 1886-1891. 472 APPENDIX F {PART II) Table 22 Mortality from Cancer in Twenty Large American Cities 1881-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 5,673,905 2,812 49.6 1906 11,472,516 8,713 75.9 1882 5,869,498 2,820 48.0 1907 11,747,948 9,274 78.9 1883 6,065,384 2,847 46.9 1908 12,023,381 9,355 77.8 1884 6,261,552 3,137 50.1 1909 12,298,814 9,934 80.8 1885 6,458,008 30,328,347 3,119 48.3 48.6 1910 12,574,254 10,425 82.9 1881-1885 14,735 1906-1910 60,116,913 47,701 79.3 1886 6,658,686 3,209 48.2 1911 12,849,687 10,713 83.4 1887 6,859,665 3,495 51.0 1912 13,125,121 11,203 85.4 1888 7,059,924 3,512 49.7 1913 13,400,553 11,971 89.3 1889 7,261,499 3,567 49.1 1890 7,463,170 4,101 54.9 Note: Includes Baltimore, Md., Bos- ton, Mass., Brooklyn, IN . 1 ., v^narieston. 1886-1890 35,302,944 17,884 60.7 S. C., Chicago, 111., Cincinnati, < 3hio, Day- ton, Ohio, Hartford, C onn.. He boken. N. 1891 1892 1893 7,702,582 7,942,266 8,182,229 4,213 4,371 4,431 54.7 55.0 54.2 J., Jersey City, N. J., NashWUe, Tenn., Newark, N. J., New Haven, Conn., New Orleans, La., New York, N. Y.. Philadel- 1894 1895 8,422,476 8,662,957 4,547 4,951 54.0 57.2 55.0 phia, Pa., Pro\-idence, R. I., Sava St. Louis, Mo., Washington, D nnah, Ga., C. 1891-1895 40,912,510 22,513 1896 8,909,328 5,178 58.1 1897 9,155,967 5,325 58.2 1898 9,402,921 5,649 60.1 1899 9,650,196 6,047 62.7 1900 9,897,855 6,334 64.0 60.7 1896-1900 47.016,267 28,533 1901 10,157,693 6,771 66.7 1902 10,417,536 6,964 66.8 1903 10,677,385 7,399 69.3 1904 10,937,234 7,778 71.1 1905 11,197,087 8,215 73.4 1901-1905 53,386,935 37,127 69.C 473 APPENDIX F {PART II) Table 23 Mortality from Cancer in Southern Cities, White 1891-1914 Deaths Rate per Deaths Rate per Year Population from Cancer 100,000 Population Year Population from Cancer 100,000 Population 1891 891,023 480 53.9 1906 1.165,457 887 76.1 1892 907,130 438 48.3 1907 1,187,034 956 80.5 1893 923,238 512 55.5 1908 1,208,611 976 80.8 1894 939,347 464 49.4 1909 1,230,188 979 79.6 1895 955,456 541 56.6 52.7 1910 1906-1910 1,251,766 1,107 88.4 1891-1895 4,616,194 2,435 6.043,056 4,905 81.2 1896 971,566 576 59.3 1911 1,273,338 1,071 84.1 1897 987,678 563 57.0 1912 1,294,911 1,159 89.5 1898 1,003,791 570 56.8 1913 1,316,492 1,272 96.6 1899 1,019,904 613 60.1 1914 1,338,076 1,248 93.3 1900 1,036,017 615 59.4 Note: ington. Tr"1"'l'^=' T«„U;^/^,-a TiHr Wash- 1896-1900 5,018,956 2,937 58.5 D. C, New Orleans, La., Charles- ton, S. C , Memphis Tenn., Nashville, 1901 1,057,588 664 62.8 Tenn., Richmond, Va., Savannah Ga. 1902 1,079,160 713 66.1 1903 1,100,732 753 68.4 1904 1,122,305 824 73.4 1905 1,143,880 846 74.0 69.0 1901-1905 5,503,665 3,800 Table 24 Mortality from Cancer in Southern Cities, Colored 1891-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 358,638 144 40.2 1906 448,736 247 55.0 1892 365,127 129 35.3 1907 454,016 280 61.7 1893 371,576 143 38.5 1908 459.296 265 67.7 1894 378,105 143 37.8 1909 464,576 261 66.2 1895 384,595 167 43.4 39.1 1910 1906-1910 469,857 257 64.7 1891-1895 1.858,041 726 2.296,481 1,310 57.0 1896 391,087 141 36.1 1911 475,138 296 62.3 1897 397,577 152 38.2 1912 480,419 340 70.8 1898 404,066 165 40.8 1913 485,699 357 73.5 1899 410,.557 195 47.5 1914 490,978 368 75.0 1900 417,048 197 47.2 Note: ington, D. [ncludes Ba C, New Oi 1896-1900 2,020,335 850 42.1 leans. La.. Charles- ton. S. C ., Memphis Tenn., Nashville, 1901 422,319 217 51.4 Tenn., Richmond, Va., Savannah Ga. 1902 427,610 193 45.1 1903 432,893 206 47.6 1904 438,175 232 52.9 1905 443,456 239 53.9 50.2 1901-1905 2,164,453 1,087 474 APPENDIX F {PART II) Table 25 Mortality from Cancer in Augusta, Ga. 1891-1913 Year Deaths Rate per Deaths Rate per (Ending Population from 100,000 Year Population from 100,000 Nov. 30) Cancer Population Cancer Population 1891 33,914 8 23.6 1906 40,400 19 47.0 1892 34,528 11 31.9 1907 40,560 13 32.1 1893 35,142 11 31.3 1908 40,720 24 58.9 1894 35,756 14 39.2 1909 40,880 20 48.9 1895 36,370 19 52.2 35.9 1910 1906-1910 41,040 • 24 58.5 1891-1895 175,710 63 203,600 100 49.1 1896 36,984 11 29.7 1911 41,200 33 80.1 1897 37,598 17 45.2 1912 41,360 23 55.6 1898 38,212 19 49.7 1913 41,520 32 77.1 1899 38,826 17 43.8 1900 39,441 16 40.6 Source: Annual Reports of the Board of Health ot Augusta, bra. 1896-1900 191,061 80 41.9 1901 39,600 17 42.9 1902 39,760 14 35.2 1903 39,920 19 47.6 1904 40,080 16 39.9 1905 40,240 24 59.6 45.1 1901-1905 199,600 90 Tab le26 Mortality from Cancer in Augusta , Ga., Males 1891- ■1912 Year Deaths Rate per Deaths Rate per (En.iinfj Population from 100,000 Year Population from 100,000 Nov. 30) Cancer Population Cancer Population 1891 15,606 3 19.2 1906 18,831 6 31.9 1892 15,897 4 25.2 1907 18,932 1 5.3 1893 16,188 4 24.7 1908 19,033 6 31.5 1894 16,479 1909 19,135 3 15.7 1895 16,770 2 11.9 16.1 1910 1906-1910 19,237 7 36.4 1891-1895 80,940 13 95,168 23 24.2 1896 17,061 1 5.9 1911 19,339 6 31.0 1897 17,352 3 17.3 1912 19,441 6 30.9 1898 17,643 8 45.3 1899 17,934 3 16.7 Source: Annual Reports of the Board 1900 18,225 88,215 2 11.0 19.3 of Health of Augusta, Ga. 1896-1900 17 1901 18,326 4 21.8 1902 18,427 2 10.9 1903 18,528 3 16.2 4904 18,629 7 37.6 1905 18,730 9 48.1 27.0 1901-1905 92,640 25 475 APPENDIX F (PART II) Table 27 Mortality from Cancer in Augusta, Ga., Females 1891-1912 Year Deaths Rate per (Ending Population from 100,000 Nov. 30) Cancer Population 1891 18,308 5 27.3 1892 18,631 7 37.6 1893 18,954 7 36.9 1894 19,277 14 72.6 1895 19,600 17 50 86.7 1891-1895 94,770 52.8 1896 19,923 10 50.2 1897 20,246 14 69.1 1898 20,569 11 53.5 1899 20,892 14 67.0 1900 21,216 14 63 66.0 1896-1900 102,846 61.3 1901 21,274 13 61.1 1902 21,333 12 56.3 1903 21,392 16 74.8 1904 21,451 9 42.0 1905 21,510 15 69.7 1901-1905 106,960 65 60.8 1906 21,569 13 60.3 1907 21,628 12 55.5 1908 21,687 18 83.0 1909 21,745 17 78.2 1910 21,803 17 77 78.0 1906-1910 108,432 71.0 1911 21,861 27 123.5 1912 21,919 17 77.6 Source: Annual Reports of the Board of Health of Augusta, Ga. 476 APPENDIX F {PART II) Table 28 Mortality from Cancer in Baltimore, Md. 1871-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1871 273,849 53 19.4 1896 479,149 344 71.8 1872 280,345 48 17.1 1897 486,601 316 64.9 1873 286,841 78 27.2 1898 494,053 331 67.0 1874 293,337 92 31.4 1899 501,505 329 65.6 1875 299,833 127 42.4 27.8 1900 1896-1900 508,957 318 62.5 1871-1875 1,434,205 398 2,470,265 1,638 66.3 1876 306,329 126 41.1 1901 513,909 358 69.7 1877 312,825 149 47.6 1902 518.861 384 74.0 1878 319,321 149 46.7 1903 523,814 370 70.6 1879 325,817 152 46.7 1904 528,767 450 85.1 1880 332,313 168 50.6 46.6 1905 1901-1905 533,720 437 81.9 1876-1880 1,596,605 744 2,619,071 1,999 76.3 1881 342,525 175 51.1 1906 538,673 450 83.5 1882 352,737 164 46.5 1907 543,626 473 87.0 1883 362,949 164 45.2 1908 548,579 449 81.8 1884 373,161 183 49.0 1909 553,532 450 81.3 1885 383,374 185 48.3 48.0 1910 1906-1910 558,485 529 94.7 1881-1885 1,814,746 871 2.742,895 2,351 85.8 1886 393,587 207 52.6 1911 563.438 526 93.4 1887 403,800 230 57.0 1912 568,391 546 96.1 1888 414,013 225 54.3' 1913 573,343 602 105.0 1889 424,226 226 53.3 1914 578,299 518 89.6 1890 434,439 276 63.5 Source: Annual Reports of th Y\n n »■ e j-zeparL- 1886-1890 2,070,065 1.164 56.2 ment of Public Safety of the City of Balti- more, Md. 1891 441,890 267 60.4 1892 449,341 233 51.9 1893 456,793 251 54.9 1894 464,245 266 57.3 1895 471,697 302 64.0 57.8 1891-1895 2,283,966 1,319 477 APPENDIX F {PART II) Table 29 Mortality from Cancer in Baltimore, Md., White 1891-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 373,350 200 53.6 1906 455,719 341 74.8 1892 379,557 160 42.2 1907 460,136 347 75.4 1893 385.764 190 49.3 1908 464,553 355 76.4 1894 391,971 174 44.4 1909 468,970 351 74.8 1895 398,178 215 54.0 48.7 1910 1906-1910 473,387 420 88.7 1891-1895 1,928,820 939 2,322,765 1,814 78.1 1896 404,386 250 61.8 1911 477,803 410 85.8 1897 410,594 229 55.8 1912 482.220 425 88.1 1898 416,802 222 53.3 1913 486,637 514 105.6 1899 423,010 245 57.9 1914 491,057 438 89.2 1900 429,218 221 51.5 Source: Annual Reports of the Uepart- 1896-1900 2,084,010 1,167 56.0 ment of Public Safety of the City of Balti- 1901 433,634 270 62.3 more, Md. 1902 438,051 275 62.8 Note: This table excludes non- residents. 1903 442,468 285 64.4 1904 446,885 331 74.1 1905 451,302 323 71.6 67.1 1901-1905 2,212,340 1.484 Table 36 Mortality from Cancer in Baltimore, Md. 1891-1914 Colored Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1891 68,540 24 35.0 1906 82,954 51 61.6 1892 69,784 23 33.0 1907 83,490 53 63.6 1893 71.029 17 23.9 1908 84,026 59 70.2 1894 72,274 22 30.4 1909 84,562 52 61.6 1895 73.519 31 42.2 32.9 1910 1906-1910 85,098 62 61.1 1891-1895 355,146 117 420,130 267 63.6 1896 74,763 26 34.8 • 1897 76,007 30 39.5 1911 85,634 55 64.2 1898 77,251 34 44.0 1912 86,169 69 68.5 1899 78,495 35 44.6 1913 86,706 88 101.5 1900 79,739 32 40.1 40.6 1914 Source: 87,242 80 Annual Reports of tl 91.7 1896-1900 386,255 157 le Depart- ment of P Liblic Safety of the City of Bal- 4901 80,275 29 36.1 timore, Md. 1902 80,810 36 44.5 Note: This table excludes non -residents. 1903 81,346 26 32.0 1904 81,882 44 53.7 1905 82,418 57 69.2 47.2 1901-1905 406,731 192 478 APPENDIX F {PART It) Table 31 Mortality from Cancer in Baltimore, Md., by Organs and Parts 1893-1902 Compared with 1903-1912 Deaths from Organ or Part Cancer Buccal cavity 142 Stomach and liver 1,230 Peritoneum, intestines and rectum. . 199 Female generative organs 710 Breast 381 Skin 78 Other or not specified organs 459 Allorgans 3,199 Rate per 100,000 Population 2.9 25.1 4.1 14.5 7.8 1.6 9.3 65.3 Deaths from Cancer 190 1,890 463 806 460 137 734 Rate per 100,000 Population 3.5 34.6 8.5 14.8 8.4 2.5 13.4 4,680 85.7 Percentage of Increase 20.7 37.8 107.3 2.1 7.7 56.3 44.1 31.2 Source: Annual Reports of the Health Department of the City of Baltimore, Md. Table 32 Mortality from Cancer in Boston, Mass. 1881-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 368,349 241 65.4 1901 567,789 455 80.1 1882 373,860 253 67.7 1902 574,686 482 83.9 1883 379,371 293 77.2 1903 581,583 511 87.9 1884 384,882 282 73.3 1904 588,481 565 96.0 1885 390,393 274 70.2 70.8 1905 1901-1905 595,380 628 105.5 1881-1885 1,896,855 1,343 2,907,919 2,641 90.8 1886 402,009 299 74.4 1906 610,420 580 95.0 1887 413,626 324 78.3 1907 625,461 611 97.7 1888 425,243 279 65.6 1908 640,502 628 98.0 1889 436,860 306 70.0 1909 655,543 670 102.2 1890 448,477 326 72.7 72.1 1910 1906-1910 670,585 693 103.3 1886-1890 2,126,215 1,534 3,202,511 3.182 99.4 1891 458,165 317 69.2 1911 685,627 769 112.2 1892 467,853 328 70.1 1912 700,669 785 112.0 1893 477,542 307 64.3 1913 715,711 841 117.5 1894 487,231 354 72.7 1914 730,753 876 119.9 1895 496,920 391 78.7 Source: Annual Reports of the Board 1891-1895 2,387.711 1,697 71.1 of Health of the City of Boston , Mass., Annual Reports of the Registry Depart- 1896 609,714 389 76.3 ment of the City of Boston, Mass. 1897 522,508 400 76.6 1898 535,302 412 77.0 1899 548,097 402 73.3 1900 560,892 452 80.6 76.8 1896-1900 2,676,513 2,055 32 479 APPENDIX F {PART II) Table 33 Mortality from Cancer in Boston, Mass., Males 1881-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 175,371 89 50.7 1906 298,187 217 72.8 1882 177,995 72 40.5 1907 306,066 219 71.6 1883 180.616 98 54.3 1908 313,945 236 75.2 1884 183,399 94 51.3 1909 321,824 259 80.5 1885 186,182 75 428 40.3 47.4 1910 329,703 257 77.9 1881-1885 903,563 1906-1910 1,569,725 1,188 75.7 1886 192,496 82 42.6 1911 337,582 271 80.3 1887 198,810 87 43.8 1912 345,461 270 78.2 1888 205,124 85 41.4 1913 353,340 345 97.6 1889 211,439 90 42.6 1890 217,754 105 48.2 Source: Annual Reports of the Board 1886-1890 1,025,623 449 43.8 Annual Reports of the Registry Depart- ment of the City of Boston, Mass. 1891 222,136 93 41.9 1892 226,518 99 43.7 1893 230,900 97 42.0 1894 235,283 116 49.3 1895 239,666 120 525 50.1 45.5 1891-1895 1,154,503 1896 246,717 137 55.5 1897 253,768 135 53.2 1898 260,819 122 46.8 1899 267,870 125 46.7 1900 274,922 168 687 61.1 52.7 ' 1896-1900 1,304,096 1901 277,999 147 62.9 1902 281,076 146 51.9 1903 284,153 188 66.2 1904 287,231 199 69.3 1905 290,309 226 906 77.8 63.8 1901-1905 1,420,768 480 AFFEXDIX F (FART II) Table 34 Mortality from Cancer in Boston, Mass., Females 1881-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 192,978 152 78.8 1906 312,233 363 116.3 1882 195,865 181 92.4 1907 319,395 392 122.7 1883 198,755 195 98.1 1908 326,557 392 120.0 1884 201,483 188 93.3 1909 333,719 411 123.2 1885 204,211 199 97.4 92.1 1910 340,882 436 127.9 1881-1885 993,292 915 1906-1910 1,632,786 1.994 122.1 1886 209,513 217 103.6 1911 348,045 498 143.1 1887 214,816 237 110.3 1912 355,208 515 145.0 1888 220,119 194 88.1 1913 362,371 496 136.9 1889 225,421 216 95.8 1890 230,723 221 95.8 Source: Annual Reports of the Board of Health of the City of Boston Annual Reports of the Registry , Mass., Depart- 1886-1890 1,100,592 1.085 98.6 ment of the City of Bos ton, Mass. 1891 236,029 224 94.9 1892 241,335 229 94.9 1893 246,642 210 85.1 1894 251,948 238 94.5 1895 257,254 271 105.3 95.0 1891-1895 1,233.208 1,172 1896 262,997 252 95.8 1897 268,740 265 98.6 1898 274,483 290 105.7 1899 280,227 277 98.8 1900 285,970 284 99.3 99.7 1896-1900 1,372,417 1,368 1901 289,790 308 106.3 1902 293,610 336 114.4 1903 297,430 323 108.6 1904 301,250 366 121.5 / 1905 305,071 402 131.8 116.7 1901-1905 1,487,151 1,735 481 APPENDIX F {PART II) Table 35 Mortality from Cancer in Boston, Mass., by Age and Sex 1903-1912 MALES Ages Under 20. 20-29. . . . 30-39.... 40-49. . . . 50-59.... 60 and over 1,121 Deaths from Cancer Rate per 100,000 Population 50 4.6 51 8.2 137 23.9 362 88.1 621 262.7 1,121 628.6 Deaths Rate per from 100,000 Cancer Population 54 4.9 62 9.3 356 61.6 801 198.1 1,068 428.1 1,757 745.5 All ages 2,342 75.2 4,098 126.5 Source: Annual Reports of the Registry Department of the City of Boston, Mass. Table 36 Mortality from Cancer in Boston, Mass., by Organs and Parts according to Sex, 1903-1912 Organ or Part from Cancer Buccal cavity 308 Stomach and liver 2,027 Peritoneum, intestines, rectum 1,127 Female generative organs 921 Breast 657 Skin 82 Other or not specified organs. . 1,318 TOTAL Deaths Rate per 100,000 Population 4.9 31.9 17.7 14.5 10.3 1.3 20.7 MALES Deaths Rate per from 100,000 Cancer Population 248 8.0 918 29.5 446 14.3 7 44 679 0.2 1.4 21.8 FEMALES Deaths Rate per from 100,000 Cancer Population 60 1,109 681 921 650 38 1.9 34.2 21.0 28.4 20.1 1.2 19.7 All organs 6,440 101.3 2,342 75.2 4,098 126.5 Source: Annual Reports of the Registry Department of the City of Boston, Mass. 482 APPENDIX F {PART II) Table 37 Mortality from Cancer in Boston, Mass., by Organs and Parts according to Age, Males, 1903-1912 Number of Deaths 60 Organ or Part Under 20 20-29 30-39 40-49 50-59 and over Buccal cavity 1 1 3 39 75 129 Stomach and liver 3 7 60 144 264 450 Peritoneum, intestines and rectum 11 13 33 70 113 206 Breast .. 1 2 4 Skin 5 6 6 27 Other or not specified organs 35 30 46 102 161 305 Morgans 50 51 137 362 621 1,121 Rate per 100,000 Population Buccalcavity 0.1 0.2 0.5 9.5 31.7 72.3 Stomach and liver 0.3 1.1 8.7 35.1 111.7 252.3 Peritoneum, intestines and rectum ... . 1.0 2.1 5.8 17.0 47.8 115.5 Breast. .. 0.2 0.8 2.2 Skin 0.9 1.5 2.5 15.1 Other or not specified organs 3.2 4.8 8.0 24.8 68.2 171.2 All Organs 4.6 8.2 23.9 88.1 262.7 628.6 Source : Annual Reports of the Registry Department of the City of Boston, Mass. Table 38 Mortality from Cancer in Boston, Mass., by Organs and Parts according to Age, Females, 1903-1912 NoMBER OF Deaths 60 Organ or Part Under 20 20-29 30-39 40-49 50-59 and over Buccal cavity 4 1 4 10 13 28 Stomach and liver 4 6 Q5 170 291 573 Peritoneum, intestines and rectum ... . 13 15 38 115 157 343 Generative organs 1 19 124 235 293 249 Breast 3 62 146 170 269 Skin 1 .. 2 3 4 28 Other or not specified organs 31 18 61 122 140 267 All organs 54 62 356 801 1,068 1,757 Rate per 100,000 Population Buccalcavity 0.4 0.2 0.7 2.5 5.2 11.9 Stomach and liver 0.4 0.9 11.3 42.0 116.7 243.1 Peritoneum, intestines and rectum ... . 1.2 2.3 Q.Q 28.4 62.9 145.5 Generative organs 0.1 2.9 21.5 58.1 117.5 105.7 Breast 0.5 10.7 36.1 68.1 114.1 Skin 0.1 .. 0.3 0.7 1.6 11.9 Other or not specified organs 2.7 2.5 10.5 30.3 56.1 113.3 Allorgans 4.9 9.3 61.6 198.1 428.1 745.5 Source: Annual Reports of the Registry Department of the City of Boston, Mass. 483 APPENDIX F {PART II) Table 39 Mortality from Cancer in Brooklyn, N. Y. 1871-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1871 413,155 155 37.5 1901 1,213,358 760 62.6 1872 430,211 147 34.2 1902 1,260,135 791 62.8 1873 447,267 170 38.0 1903 1,306,912 778 59.5 1874 464,323 197 42.4 1904 1,353,688 817 60.4 1875' 481,379 201 41.8 38.9 1905 1901-1905 1,400,465 899 64.2 1871-1875 2.236,335 870 6,534,558 4,045 61.9 1876 498,435 195 39.1 1906 1,447,242 975 67.4 1877 515,492 200 38.8 1907 1,494,019 993 66.5 1878 532,549 233 43.8 1908 1,540,796 1,016 65.9 1879 549,606 231 42.0 1909 1,587,573 1,110 69.9 1880 566,663 221 39.0 40.6 1910 1906-1910 1,634,351 1,212 74.2 1876-1880 2,662,745 1,080 7,703,981 5,306 68.9 1881 590,631 254 43.0 1911 1,681,129 1,221 72.6 1882 614,599 285 46.4 1912 1,727,907 1,252 72.5 1883 638,567 262 41.0 > 1913 1,774,685 1,346 75.9 1884 662,535 823 48.8 1885 686,503 301 43.8 Source: 1871-1897, Annual Reports of the Board of Health of the City oi Brooklyn 1881-1885 3,192,835 1,425 44.6 N. Y., 1898-1912, Annual Reports of the Board of Health of the City of New York, 1886 710,471 293 41.2 N. Y., 1913, Report of New York State 1887 734,439 349 47.5 Department of Health 1888 758,407 345 45.5 1889 782,375 320 40.9 1890 806,343 414 61.3 45.4 1886-1890 3.792,035 1,721 1891 842,366 416 49.4 1892 878,390 538 61.2 1893 914,414 441 48.2 1894 950,438 457 48.1 1895 986,462 572 58.0 63.0 1891-1895 4,572,070 2,424 1896 1,022,486 534 62.2 1897 1,058,510 561 53.0 1898 1.094,534 632 67.7 1899 1,130,558 701 62.0 1900 1,166,582 695 69.6 67.1 1896-1900 5,472,670 3,123 484 APPENDIX F {PART J I) Table 40 Mortality from Cancer in Brooklyn, N. Y., Males 1872-1878 and 1903-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1872 206,682 31 15.0 1906 715,367 343 47.9 1873 215,009 50 23.3 1907 738,973 403 54.5 1874 223,336 64 28.7 1908 762,579 335 43.9 1875 231,663 63 27.2 1909 786,185 414 52.7 1876 239,990 60 25.0 1910 809,791 438 54.1 1877 1878 248,318 256,646 57 72 23.0 28.1 24.5 1906-1910 1911 3,812,895 833,397 1,933 479 50.7 1872-1878 1,621,644 397 57.5 1912 857,003 492 57.4 1903 644,549 293 45.5 1913 880,609 534 60.6 1904 1905 668,155 691,761 297 313 44.5 45.2 Source: 1872-1878, Annual Reports of the Board of Health of the City of Brooklyn, N. Y., 1903-1913, Annual Reports of the Board of Health of the City of New York. N.Y. Table 41 Mortality from Cancer in Brooklyn, N, Y. 1872-1878 and 1903-1913 Females Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1872 223,529 116 51.9 1906 731,875 632 86.4 1873 232,258 120 51.7 1907 755,046 590 78.1 1874 240,987 133 55.2 1908 778,217 681 87.5 1875 249,716 138 55.3 1909 801,388 696 86.8 1876 258,445 135 52.2 1910 824,560 774 93.9 1877 1878 267,174 275,903 143 161 53.5 58.4 54.1 1906-1910 1911 3,891,086 847,732 3,373 742 86.7 1872-1878 1,748,012 946 87.5 1912 870,904 760 87.3 1903 662,363 485 73.2 1913 894,076 812 90.8 1904 685,533 520 75.9 1905 708,704 586 82.7 Source: 1872-1878, Annual Reports of the Board of Health of the City of Brooklyn, N. Y., 1903-1913, Annual Reports of the Board of Health of the City of New York, N. Y. 485 APPENDIX F (PART II) Table 42 Mortality from Cancer in Buffalo, N. Y. 1886-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1886 209,329 78 37.3 1901 357,227 264 73.9 1887 220,041 102 46.4 1902 362,067 230 63.5 1888 231,307 110 47.6 1903 366,907 271 73.9 1889 232,491 104 44.7 1904 371,747 271 72.9 1890 255,664 132 51.6 45.8 1905 1901-1905 376,587 329 87.4 1886-1890 1,148,832 526 1,834,535 1,365 74.4 1891 263,981 119 45.1 1906 386,012 328 85.0 1892 278,727 114 40.9 1907 395,437 323 81.7 1893 281,435 138 49.0 1908 404,863 326 80.5 1894 290,590 156 53.7 1909 414,289 327 78.9 1895 300,043 133 44.3 46.7 1910 1906-1910 423,715 396 93.5 1891-1895 1,414.776 660 2,024,316 1,700 84.0 1896 309,803 166 53.6 . 1911 433,141 420 97.0 1897 319,881 188 58.8 1912 442,567 410 92.6 1898 330,287 214 64.8 1913 451,993 451 99.8 1899 341,031 207 60.7 1900 352,387 234 66.4 Source: Annual Reports of the Depart- ment of I N.Y. [paUVi of the City of Buffalo 1896-1900 1,653,389 1,009 61.0 Table 43 Mortality from Cancer in Buffalo, N. Y., by Sex 1904-1905 and 1908-1913 MALES FEMALES Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1904 1905 185,289 187,879 107 141 57.7 75.0 1904 1905 186,458 188,708 164 188 88.0 99.6 1908 1909 1910 202,652 207,577 212,502 146 121 155 72.0 58.3 72.9 1908 1909 1910 202,211 206,712 211,213 180 206 241 89.0 99.7 114.1 1911 1912 1913 217,427 222,352 227,277 170 170 189 78.2 76.5 83.2 1911 1912 1913 215,714 220,215 224,716 250 240 262 115.9 109.0 116.6 Source ment of Annual Reports of the Depart- HeaUh of the City of Buffalo, N.Y. 486 APPENDIX F (PART II) Table 44 Mortality from Cancer in Charleston, S. C. 1881-1914 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1881 50,481 18 35.7 1906 57,621 24 41.7 1882 50,978 22 43.2 1907 57,924 40 69.1 1883 51,475 22 42.7 1908 58,227 24 41.2 1884 51,972 27 52.0 1909 58,530 32 54.7 1885 52,469 28 53.4 45.5 1910 1906-1910 58,833 36 61.2 1881-1885 257,375 117 291,135 156 53.6 1886 52,966 33 62.3 1911 59,135 46 77.8 1887 53,463 15 28.1 1912 59,437 35 58.9 1888 53,960 23 42.6 1913 59,739 41 68.6 1889 54,457 26 47.7 1914 60,041 34 56.6 1890 54,955 26 47.3 Source: Charleston Year Books S. C. of the City of 1886-1890 269,801 123 45.6 1891 55,040 30 54.5 1892 55,125 26 47.2 1893 55,210 30 54.3 - 1894 55,295 26 47.0 1895 55,380 34 61.4 52.9 1891-1895 276,050 146 1896 55,465 34 61.3 1897 55,550 26 46.8 1898 55,635 19 34.2 1899 55,721 54 96.9 1900 55,807 35 62.7 60.4 1896-1900 278,178 168 1901 56,109 33 58.8 1902 56,411 30 53.2 1903 56,713 29 51.1 1904 57,015 27 47.4 1905 57,318 30 52.3 52.5 1901-1905 283,566 149 487 APPENDIX F {PART II) Table 45 Mortality from Cancer in Charleston, S. C, White 1881-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 22,821 11 48.2 1906 26,352 20 75.9 1882 22,943 12 52.3 1907 26,705 18 67.4 1883 23,065 9 39.0 1908 27,058 20 73.9 1884 23,187 11 47.4 1909 27,411 18 65.7 1885 23,309 13 55.8 48.6 1910 1906-1910 27,764 23 82.8 1881-1885 115,325 56 135,290 99 73.2 1886 23,431 18 76.8 1911 28,116 24 85.4 1887 23,553 6 25.5 1912 28,468 24 84.3 1888 23,675 15 63.4 1913 28,820 25 86.7 1889 23,797 18 75.6 1914 29,172 22 75.4 1890 23,919 14 58.5 Source: Charleston Year Books S. C. of the City of 1886-1890 118,375 71 60.0 1891 23,950 16 66.8 1892 23,982 13 54.2 1893 24,014 16 66.6 1894 24,046 13 54.1 1895 24,078 15 62.3 60.8 1891-1895 120,070 73 1896 24,110 21 87.1 1897 24,142 15 62.1 1898 24,174 10 41.4 1899 24,206 34 140.5 1900 24,238 20 82.5 82.7 1896-1900 120,870 100 1901 24,590 18 73.2 1902 24,942 13 52.1 1903 25,294 17 67.2 1904 25,646 13 50.7 1905 25,999 18 69.2 62.5 1901-1905 126,471 79 488 APPENDIX F {PART II) Table 46 Mortality from Cancer in Charleston, S. C, Colored 1881-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 27,660 7 25.3 1906 31,269 4 12.8 1882 28,035 10 35.7 1907 31,219 22 70.5 1883 28,410 13 45.8 1908 31,169 4 12.8 1884 28,785 16 55.6 1909 31,119 14 45.0 1885 29,160 15 51.4 42.9 1910 1906-1910 31,069 13 41.8 1881-1885 142,050 61 155,845 57 36.6 1886 29,535 15 50.8 1911 31,019 22 70.9 1887 29,910 9 30.1 1912 30,969 11 35.5 1888 30,285 8 26.4 1913 30,919 16 51.7 1889 30,660 8 26.1 1914 30,869 12 38.9 1890 31,036 12 38.7 Source: Year Books of the City of 1886-1890 151,426 52 34.3 Charleston, S. C. 1891 31,090 14 45.0 1892 31,143 13 41.7 1893 31,196 14 44.9 1894 31,249 13 41.6 1895 31,302 19 60.7 46.8 1891-1895 155,980 73 1896 31,355 13 41.5 1897 31,408 11 35.0 1898 31,461 9 28.6 1899 31,515 20 63.5 1900 31,569 15 47.5 43.2 1896-1900 157,308 68 1'901 31,519 15 47.6 1902 31,469 17 54.0 1903 31,419 12 38.2 1904 31,369 14 44.6 1905 31,319 12 38.3 44.6 1901-1905 157,095 70 489 APPENDIX F {PART II) Table 47 Mortality from Cancer in Chicago, 111. 1871-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1871 319,397 68 21.3 1901 1,747,245 1,097 62.8 1872 339,817 75 22.1 1902 1,795,915 1,169 65.1 1873 360,238 107 29.7 1903 1,844,586 1,172 63.5 1874 380,659 110 28.9 1904 1,893,257 1,203 63.5 1875 401,080 123 30.7 26.8 1905 1901-1905 1,941,928 1,280 65.9 1871-1875 1,801,191 483 9,222,931 5,921 64.2 1876 421,501 122 28.9 1906 1,990,599 1,430 71.8 1877 441,922 130 29.4 1907 2,039,270 1,538 75.4 1878 462,343 177 38.3 1908 2,087,941 1,571 75.2 1879 482,764 177 36.7 1909 2,136,612 1,646 77.0 1880 503,185 163 32.4 33.3 1910 1906-1910 2,185,283 1,804 82.6 1876-1880 2,311,715 769 10,439,705 7,989 76.5 1881 562,851 217 38.6 1911 2,233,953 1,799 80.5 1882 622,517 220 35.3 1912 2,282,623 1,798 78.8 1883 682,183 232 34.0 1913 2,331,293 2,004 86.0 1884 741,849 265 35.7 1885 801,515 249 31.1 Source: Annual Reports of th 3 Depart- ment of Health of Chicago, 111. 1910-1913, 1881-1885 3,410,915 1,183 34.7 United States Mortality Statistics. 1886 861,182 230 26.7 1887 920,849 301 32.7 1888 980,516 361 36.8 1889 1,040,183 379 36.4 1890 1,099,850 461 41.9 35.3 1886-1890 4,902,580 1,732 1891 1,159,722 546 47.1 1892 1,219,594 546 44.8 1893 1,279,466 617 48.2 1894 1,339,338 640 47.8 1895 1,399,210 682 48.7 47.4 1891-1895 6,397,330 3,031 1896 1,459,083 734 50.3 1897 1,518,956 773 50.9 1898 1,578,829 893 56.6 1899 1^638,702 985 60.1 1900 1,698,575 986 58.0 55.4 1896-1900 7,894,145 4,371 490 APPENDIX F (PART IP) Table 48 Mortality from Cancer in Chicago, III. 1895-1913 Males Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1895 715,903 288 40.2 1906 1,020,820 660 64.7 1907 1,047,056 663 63.3 1896 745,404 335 44.9 1908 1,073,292 685 63.8 1897 774,905 323 41.7 1909 1,099,528 726 66.0 1898 804,406 369 45.9 1910 1,125,764 768 68.2 1899 833,907 428 51.3 1900 863,408 423 49.0 46.7 1906-1910 1911 5,366,460 1,152,000 3,502 757 65.3 1896-1900 4,022,030 1.878 65.7 1912 1,178,236 777 65.9 WOl 889,643 463 52.0 1913 1,204,472 851 70.7 1902 915,878 482 52.6 1903 942,113 542 57.5 Source: Annual Reports of the Depart- 1904 968,348 504 52.0 ment of Health of Chicago, 111. 1910-1913, 1905 994,584 576 57.9 54.5 United States Mortality Statist ics. 1901-1905 4,710,566 2,567 Table 49 Mortality from Cancer in Chicago, 111. 1895-1913 Females Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1895 683,307 394 57.7 1906 969,779 770 79.4 1907 992,214 875 88.2 1896 713,679 399 55.9 1908 1,014,649 886 87.3 1897 744,051 450 60.5 1909 1,037,084 920 88.7 1898 774,423 524 67.7 1910 1,059,519 1,036 97.8 1899 804,795 557 69.2 1900 835,167 663 67.4 64.4 1906-1910 1911 5,073,245 1,081,953 4,487 1,042 88.4 1896-1900 3,872,115 2,493 96.3 1912 1,104,387 1,021 92.4 1901 857,602 634 73.9 1913 1,126,821 1,153 102.3 1902 880,037 687 78.1 1903 902,473 630 69.8 Source : Annual Reports of the Depart- 1904 924,909 699 75.6 ment of Health of Chicag 3. 111. 1910-1913, 1905 947,344 704 74.3 74.3 United States Mortality Statist ,1CS. 1901-1905 4,512,365 3,354 491 APPENDIX F {PART II) Table 50 Mortality from Cancer in Chicago, 111., by Organs and Parts according to Sex, 1903-1912 Organ or Part Buccal cavity Stomach and liver Peritoneum, intestines, rectum Female generative organs Breast Skin Other or not specified organs. . . Deaths from Cancer 388 6,542 1,611 2,440 1,128 212 2,920 TOTAL Rate per 100,000 Population 1.9 31.7 7.8 11.8 5.5 1.0 14.2 MALES Deaths Rate per from 100,000 Cancer Population 334 3.2 3,617 34.1 725 6.8 5 122 1,855 0.0 1.2 17.5 FEMALES Deaths Rate per from Cancer 54 2,925 886 2,440 1,123 90 1,065 100,000 Population 0.5 24.3 11.2 0.9 10.6 AUorgans 15,241 73.9 6,658 62.8 8,583 85.5 Source: Annual Reports of the Department of Health of the City of Chicago, 111. Table 51 Mortality from Cancer in Cincinnati, Ohio 1871-1913 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1871 220,129 49 22.3 1896 314,302 209 66.5 1872 224,019 66 29.5 1897 317,202 189 59.6 1873 227,909 61 26.8 1898 320,102 195 60.9 1874 231,799 66 28.5 1899 323,002 205 63.5 1875 235,689 79 33.5 28.2 1900 1896-1900 325,902 198 60.8 1871-1875 1,139,545 321 1,600,510 996 62.2 1876 239,579 76 31.7 1901 329,670 223 67.6 1877 243,469 80 32.9 1902 333,439 227 68.1 1878 247,359 66 26.7 1903 337,208 267 79.2 1879 251,249 88 35.0 1904 340,977 250 73.3 1880 255,139 105 41.2 33.6 1905 1901-1905 344,746 228 66.1 1876-1880 1,236,795 415 1,686,040 1.195 70.9 1881 259,315 103 39.7 1906 348,515 376 107.9 1882 263,492 111 42.1 1907 352,284 305 86.6 1883 267,669 115 43.0 1908 356,053 328 92.1 1884 271,846 98 36.1 1909 359,822 344 95.6 1885 276,023 93 33.7 38.9 1910 1906-1910 363,591 302 83.1 1881-1885 1,338,345 520 1,780,265 1,655 93,0 1886 1887 1888 1889 280,200 284,377 288,554 292,731 124 137 154 124 44.3 48.2 53.4 42.4 1911 1912 1913 367,360 371,129 374,898 354 352 394 96.4 94.8 105.1 1890 296,908 129 43.4 Source: Annual Reports of the Board 1886-1890 1,442,770 608 46.3 of Health ot the Uity ot l^mcinnati, Uliio. 1891 299,807 159 53.0 1892 302,706 148 48.9 1893 305,605 160 52.4 1894 308,504 184 59.6 1895 311,403 152 48.8 52.6 1891-1895 1,528,025 803 492 APPENDIX F {PART II) Table 52 Table 53 Mortality from Cancer in Cincinnati Mortality from Cancer in Cincinnati Ohio, Males Ohio, Females 1891-191 13 Deaths Rate per 1891-1913 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 146,223 53 36.2 1891 153,584 106 69.0 1892 147,436 61 41.4 1892 155,270 87 56.0 1893 148;649 60 40.4 1893 156,956 100 63.7 1894 149,862 77 51.4 1894 158,642 107 67.4 1895 151,075 49 32.4 40.4 1895 1891-1895 160,328 103 64.2 1891-1895 743,245 300 784,780 503 64.1 1896 152,288 75 49.2 1896 162,014 134 82.7 1897 153,501 74 48.2 1897 163,701 115 70.3 1898 154,714 88 56.9 1898 165,388 107 64.7 1899 155,927 84 53.9 1899 167,075 121 72.4 1900 157.140 83 52.8 52.2 1900 1896-1900 168,762 115 68.1 1896-1900 773,570 404 826,940 592 71.6 1901 159,177 77 48.4 1901 170,493 146 85.6 1902 161,214 77 47.8 1902 172,225 150 87.1 1903 163,251 97 59.4 1903 173,957 170 97.7 1904 165,288 88 53.2 1904 175,689 162 92.2 1905 167,325 83 49.6 51.7 1905 1901-1905 177,421 145 81.7 1901-1905 816,255 422 869,785 773 88.9 1906 169,362 108 63.8 1906 179,153 268 149.6 1907 171,399 101 58.9 1907 180,885 204 112.8 1908 173,436 129 74.4 1908 182,617 199 109.0 1909 175,473 125 71.2 1909 184,349 219 118.8 1910 177,511 126 71.0 67.9 1910 1906-1910 186,080 176 94.6 1906-1910 867,181 589 913.084 1.066 116.7 1911 179,549 130 72.4 1911 187,811 224 119.3 1912 181,587 134 73.8 1912 189,542 218 115.0 1913 183,625 141 76.8 1913 191,273 253 132.3 Source: Annual Reports of the Board Source: Annual Reports of the Board of Health of the City of Cincinnati, Ohio. of Health of the City of Cincinnati, Ohio. APPENDIX F {PART II) Table 54 Mortality from Cancer in Cleveland, Ohio 1884-1913 Deaths Rate per Year Population from 100,000 Cancer Population 1884 200,627 78 38.9 1885 210,748 73 34.6 1886 220,869 76 34.4 1887 230,990 100 43.3 1888 241,111 100 41.5 1889 251,232 102 40.6 1890 261,353 111 42.5 1886-1890 1,205,555 489 40.6 1891 273,394 111 40.6 1892 285,435 102 35.7 1893 297,476 150 50.4 1894 309,517 138 44.6 1895 321,558 192 59.7 1891-1895 1,487,380 693 46.6 1896 333,600 165 49.5 1897 345,642 183 52.9 1898 357,684 171 47.8 1899 369,726 184 49.8 1900 381,768 187 49.0 1896-1900 1,788,420 890 49.8 1901 399,657 211 52.8 1902 417,546 196 46.9 1903 435,435 228 52.4 1904 453,324 233 51.4 1905 471,213 269 57.1 1901-1905 2,177,175 1,137 52.2 1906 489,103 290 59.3 1907 506,993 295 58.2 1908 524,883 328 62.5 1909 542,773 333 61.4 1910 560,663 405 72.2 1906-1910 2,624,415 1,651 62.9 1911 578,553 422 72.9 1912 596,443 472 79.1 1913 614,333 489 79.6 Source: Annual Reports of the Public Health Depart- ment of the City of Cleveland, Ohio. 494 APPENDIX F {PART II) Table 55 Table 56 Mortalit y from Cancer in Ohio, Males Cleveland Mortality from Cancer in Ohio, Females Cleveland 1885- 1913 Rate per 100,000 Population Year 1885- 1913 Year Population Deaths from Cancer Population Deaths from Cancer Rate per 100,000 Population 1885 107,121 30 28.0 1885 103,627 43 41.5 1886 112,210 39 34.8 1886 108,659 37 34.1 1887 1888 1889 1890 122,373 127,447 132,517 36 42 44 1886-1890 494,547 1891 1892 1893 1894 1895 138,527 144,537 150,546 156,556 162,566 161 40 40 56 5Q 29.4 33.0 33.2 32.6 28.9 27.7 37.2 35.8 50.4 1887 1888 1889 1890 118,738 123,785 128,836 1886-1890 480,018 1891 1892 1893 1894 1895 134,867 140,898 146,930 152,961 158,992 64 60 67 71 62 110 53.9 48.5 52.0 47.5 52.6 44.0 64.0 53.6 69.2 1891-1895 752,732 274 36.4 1891-1895 734,648 419 57.0 1896 168,576 80 47.5 1896 165,024 85 51.5 1897 174,586 67 38.4 1897 171,056 116 67.8 1898 180,596 76 42.1 1898 177,088 95 53.6 1899 186,606 85 45.6 1899 183,120 99 54.1 1900 192,616 81 42.1 43.1 1900 1896-1900 189,152 106 56.0 1896-1900 902.980 389 885,440 501 56.6 1901 202,280 76 37.6 1901 197,377 135 68.4 1902 211,944 86 40.6 1902 205,602 110 53.5 1903 221,608 91 41.1 1903 213,827 137 64.1 1904 231,272 106 45.8 1904 222,052 127 57.2 1905 240,937 120 49.8 43.2 1905 1901-1905 230,276 149 64.7 1901-1905 1,108,041 479 1,069,134 658 61.5 1906 250,602 111 44.3 1906 238,501 179 75.1 1907 260,267 114 43.8 1907 246,726 181 73.4 1908 269,932 141 52.2 1908 254,951 187 73.3 1909 279,597 135 48.3 1909 263,176 198 75.2 1910 289,262 160 55.3 49.0 1910 1906-1910 271,401 245 90.3 1906-1910 1,349,660 661 1,274,755 990 77.7 1911 298,927 173 57.9 1911 279,626 249 89.0 1912 308,592 204 66.1 1912 287,851 268 93.1 1913 318,257 227 71.3 1913 296,076 262 88.5 Source: Annual Report s of the Public Source: Annual Reports of the Public Health Department of the City of Cleve- Health Department of the City of Cleve- land, Ohio. land, Ohio. 495 APPENDIX F (PART II) Table 57 Mortality from Cancer in Cleveland, Ohio, by Organs and Parts according to Sex, 1903-1912 TOTAL MALES FEMALES Deaths Rate per Deaths Rate per Deaths Rate per Organ or Part from 100,000 from 100,000 from 100,000 Cancer Population Cancer Population Cancer Population Buccal cavity 47 0.9 36 1.4 11 0.4 Stomach and liver 1,299 278 25.2 5.4 664 105 25.0 4.0 635 173 25.3 Peritoneum, intestines, rectum 6.9 Female generative organs 408 7.9 6 0.2 402 16.0 Breast 173 3.4 5 0.2 168 6.7 Skin 63 1.2 38 1.4 25 1.0 Other or not specified organs. . . 1,007 3,275 19.5 63.5 501 18.9 51.1 506 20.2 All organs 1.355 1,920 76.5 Source : Annual Reports of the Public Health Department of the City of Cleveland, Ohio. Table 58 Mortality from Cancer in Columbus, Ohio 1900-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1900 125,560 85 67.7 1906 159,130 101 63.5 1907 164,725 102 61.9 1901 131,155 66 50.3 1908 170,320 135 79.3 1902 136,750 86 62.9 1909 175,915 173 98.3 1903 142,345 91 63.9 1910 181,511 166 91.5 1904 147,940 101 68.3 1905 153,535 104 67.7 62.9 1906-1910 1911 851,601 187,106 677 163 79.5 1901-1905 711,725 448 87.1 1912 192,701 186 96.5 1913 198,296 181 91.3 Source: United States Mortality Sta- tistics. 496 APPENDIX F {PART II) Table 59 Mortality from Cancer in Dayton, Ohio 1871-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1871 31,293 11 35.2 1896 75,686 46 60.8 1872 32.113 11 34.3 1897 78,097 54 69.1 1873 32,933 12 36.4 1898 80,509 43 53.4 1874 33,753 9 26.7 1899 82,921 . 55 66.3 1875 34,573 9 26.0 31.6 1900 1896-1900 85,333 56 65.6 1871-1875 164,665 52 402,546 254 63.1 1876 35,394 17 48.0 1901 88,457 66 74.6 1877 36,215 8 22.1 1902 91,581 54 59.0 1878 37,036 11 29.7 1903 94,705 66 69.7 1879 37,857 17 44.9 1904 97,829 66 67.5 1880 38,678 19 49.1 38.9 1905 1901-1905 100,953 70 69.3 1876-1880 185,180 72 473,525 322 68.0 1881 40,932 18 44.0 1906 104,077 95 91.3 1882 43,186 19 44.0 1907 107,202 91 84.9 1883 45,440 9 19.8 1908 110,327 77 69.8 1884 47,694 15 31.5 1909 113,452 119 104.9 1885 49,948 18 36.0 34.8 1910 1906-1910 116,577 106 90.9 1881-1885 227,200 79 551,635 488 88.5 1886 52,202 22 42.1 1911 119,701 111 92.7 1887 54,456 25 45.9 1912 122,825 112 91.2 1888 56,710 28 49.4 1913 125,949 109 86.5 1889 58,965 26 44.1 1890 61,220 28 45.7 Source: Annual Reports of th 3 Board of Health of the City of Dayton, Ohio. 1886-1890 283,553 129 45.5 United States Mortality Statistics, 1909- 1913. 1891 63,631 52 81.7 1892 66,042 SI 46.9 1893 68,453 33 48.2 1894 70,864 53 74.8 1895 73,275 41 56.0 61.4 1891-1895 342,265 210 497 APPENDIX F (PART II) Table 60 Mortality from Cancer in Dayton, Ohio, Males 1876-1908 Deaths Rate per Deaths Rate per Year Population from : 00,000 Year Population from 100,000 Cancer Population Cancer Population 1876 17,521 8 45.7 1901 43,812 30 68.5 1877 17,935 2 11.2 1902 45,482 24 52.8 1878 18,349 8 43.6 1903 47,152 27 57.3 1879 18,763 7 37.3 1904 48,822 23 47.1 1880 19,177 8 33 41.7 36.0 1905 . 1901-1905 50,493 23 45.6 1876-1880 91,745 235,761 127 53.9 1881 20,308 8 39.4 1906 52,164 42 80.5 1882 21,439 5 23.3 1907 53,835 41 76.2 1883 22,570 1 4.4 1908 55,5QQ 27 48.6 1884 23,701 1 4.2 1885 24,832 7 28.2 Source: Annual Reports of the Board nf Health of the City of Dayt )n Ohio 1881-1885 112,850 22 19.5 Ul ±±CtlILli 1886 25,963 12 46.2 1887 27,094 10 36.9 1888 28,225 8 28.3 1889 29,357 11 37.5 1890 30,489 8 26.2 34.7 I 1886-1890 141,128 49 1891 31,654 18 56.9 1892 32,819 14 42.7 1893 33,984 13 38.3 1894 35,149 19 54.1 1895 36,314 14 38.6 45.9 1891-1895 169,920 78 1896 37,479 20 53.4 1897 38,644 22 56.9 1898 39,810 20 50.2 1899 40,976 18 43.9 1900 42,142 15 35.6 47.7 1896-1900 199,051 95 498 APPENDIX F {PART II) Table 61 Mortality from Cancer in Dayton, Ohio, Females 1876-1908 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1876 17,873 9 50.4 1901 44,645 36 80.6 1877 18,280 6 32.8 1902 46,099 30 65.1 1878 18,687 3 16.1 1903 47,553 39 82.0 1879 19,094 10 52.4 1904 49,007 43 87.7 1880 19,501 11 56.4 41.7 1905 50,460 47 93.1 1876-1880 93,435 39 1901-1905 237,764 195 82.0 1881 20,624 10 48.5 1906 51,913 53 102.1 1882 21,747 14 64.4 1907 53,367 50 93.7 1883 22,870 8 35.0 1908 54,821 50 91.2 1884 23,993 14 58.4 1885 25,116 11 43.8 Source: Annual Reports of the Board of Health of the City of Dayton, Ohio. 1881-1885 114,350 57 49.8 1886 26,239 10 38.1 1887 27,362 15 54.8 1888 28,485 20 70.2 1889 29,608 15 50.7 1890 30,731 20 65.1 56.2 1886-1890 142,425 80 1891 31,977 34 106.3 1892 33,223 17 51.2 1893 34,469 20 58.0 1894 35,715 34 95.2 1895 36,961 27 73.0 76.6 1891-1895 172,345 132 1896 38,207 26 68.1 « 1897 39,453 32 81.1 1898 40,699 23 56.5 1899 41,945 37 88.2 1900 43,191 41 94.9 78.1 1896-1900 203,495 159 499 APPENDIX F {PART II) Table 62 Mortality from Cancer in Denver, Colo. 1892-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1892 112,141 25 22.3 1906 181,570 133 73.2 1893 114,855 48 41.8 1907 189,522 115 60.7 1894 117,569 43 36.6 1908 197,475 159 80.5 1895 120,284 52 43.2 1909 205,428 171 83.2 1910 213,381 191 89.5 1892-1895 464,849 168 36.1 1906-1910 987,376 769 77.9 1896 122,999 62 50.4 1897 125,714 77 61.3 1911 221,334 166 75.0 1898 128,429 71 55.3 1912 229,287 200 87.2 1899 131,144 86 65.6 1913 237,240 181 76.3 1900 133,859 68 50.8 Source : of Health Annual "Rpn""*" <->* t^'^ ■R.-.qt.,4 1896-1900 642,145 364 56.7 of the City of Denver, Colo., 1899-1903, Monthly Reports of the Board 1901 141,811 101 71.2 of Health of the City of Denver, Colo. 1902 149,763 85 56.8 1903 157,715 88 . 55.8 1904 1905 173,618 119 68.5 63.1 1901-1905 622,907 393 Table 63 Mortality from Cancer in Denver, Colo., by Sex 1905-1913 MALES FEMALES Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1905 86,992 39 44.8 1905 86,626 80 92.4 1906 91,072 50 54.9 1906 90,498 83 91.7 1907 95,152 53 55.7 1907 94,370 62 65.7 1908 99,233 68 68.5 1908 98,242 91 92.6 1909 103.314 68 65.8 1909 102,114 103 100.9 1910 107,395 74 68.9 1910 105,986 117 110.4 1906-1910 496,166 313 63.1 1906-1910 491,210 456 92.8 1911 1912 1913 111,476 115,557 119,638 73 84 68 65.5 72.7 56.8 1911 1912 1913 109,858 113,730 117,602 93 84.7 116 102.0 113 96.1 Source: Annual Reports of the Board of Health of the City of Denver, Colo. 500 APPENDIX F {PART II) Table 64 Mortality from Cancer in Denver, Colo., by Organs and Parts according to Sex, 1905-1912 TOTAL MALES FEMALES Deaths Rate per Deaths Rate per Deaths Rate per Organ or Part from 100,000 from 100,000 from 100,000 Cancer Population Cancer Population Cancer Population Buccal cavity 38 2.4 33 4.1 5 0.6 Stomach and liver 458 28.4 253 31.2 205 25.6 Peritoneum, intestines, rectum 157 9.7 80 9.9 77 9.6 Female generative organs 229 14.2 229 28.6 Breast 98 6.1 i o.i 97 12.1 Skin 25 1.6 14 1.7 11 1.4 Other ornot specified organs. . 249 15.4 77.8 128 509 15.8 62.8 121 745 15.1 All organs 1,254 93.0 Source: Annual Reports of the Health Department of the City of Denver, Colo. Table 65 Mortality from Cancer in Detroit, Mich. 1883-1913 Year Deaths Rate per Year Deaths Rate per (Ending Population from 100,000 (Ending Population from 100,000 June 30) Cancer Population June 30) Cancer Population 1883 128,596 50 38.9 1901 293,675 180 61.3 1884 132,956 52 39.1 1902 301,647 194 64.3 1903 309,619 224 72.3 1886 153,818 83 54.0 1904 317,591 237 74.6 1887 165,447 89 53.8 1905 342,286 200 58.4 1888 177,955 90 50.6 1889 1901-1905 1,564,818 1,035 66.1 1890 205,876 88 42.7 1906 366,982 272 74.1 1886-1890 703,096 350 49.8 1907 391,678 240 61.3 1908 416,374 251 60.3 1891 213,432 109 51.1 1909 441,070 266 60.3 1892 221,265 94 42.5 1910 465,766 314 67.4 1893 1894 237,798 103 43.3 45.5 1906-1910 1911 2,081,870 490,461 1,343 313 64.5 1891-1894 672,495 306 63.8 1912 515,156 332 64.4 1896 252,796 162 64.1 1913 539,851 327 60.6 1897 260,645 163 62.5 1898 268,738 158 58.8 Source: Annual Reports of the Board of 1899 277,082 158 57.0 Health of the City of Detroit, Mich., United 1900 285,704 179 62.7 States MortaUty Statistics, 1908. Note: years. 1894 and 1908 are calendar 1896-1900 1,344,965 820 61.0 501 APPENDIX F (PART II) Table 66 Mortality from Cancer in Hartford, Conn. 1881-1913 Year (Fiscal) Population Deaths from Cancer Rate per 100,000 Population Year (Fiscal) Population Deaths from Cancer Rate per 100,000 Population 1881 43,136 28 64.9 1906 91,287 70 76.7 1882 44,257 20 45.2 1907 93,194 98 105.2 1883 45.378 24 52.9 1908 95,101 77 81.0 1884 46,499 31 66.7 1909 97,008 98 101.0 1885 47,620 26 54.6 56.9 1910 1906-1910 98,915 94 437 95.0 1881-1885 226,890 129 475,505 91.9 1886 1887 1888 1889 48,742 49,864 50,986 52,108 20 30 29 21 41.0 60.2 56.9 40.3 (Calendar) 1911 1912 1913 100,821 102,727 104,633 95 118 133 94.2 114.9 127.1 1890 53,230 39 73.3 54.5 Source: Annual reports of the Health of the City of Hartford, C Note: Data for 1881-1910 art Board of 1886-1890 254,930 139 onn. ; for fiscal 1891 55,892 29 51.9 years ending February 28th of following 1892 58,554 31 52.9 year. 1893 61,216 28 45.7 1894 63,878 24 37.6 1895 66,540 40 60.1 49.7 1891-1895 306,080 152 1896 69,202 39 56.4 1897 71,864 42 58.4 1898 74,526 41 55.0 1899 77,188 43 55.7 1900 79,850 50 62.6 57.7 1896-1900 372,630 215 1901 81,756 67 82.0 1902 83,662 38 45.4 1903 85,568 70 81.8 1904 87,474 73 83.5 1905 89,380 82 91.7 77.1 1901-1905 427,840 330 502 APPENDIX F {PART II) Table 67 Table 68 Mortality from Cancer in Hartford, Conn., Males Mortality from Cancer in Hartford, Conn., Females 1886-19 13 Deaths from Cancer Rate per 100,000 Population Year (Fiscal) 1886-19 13 Deaths from Cancer Year (Fiscal) Population Population Rate per 100,000 Population 1886 23,835 7 29.4 1886 24,907 13 52.2 1887 24,381 10 41.0 1887 25,483 20 78.5 1888 24,927 6 24.1 1888 26,059 23 88.3 1889 25,473 9 35.3 1889 26,635 12 45.1 1890 26,019 6 23.1 30.5 1890 1886-1890 27,211 33 121.3 1886-1890 124,635 38 130,295 101 77.5 1891 27,486 7 25.5 1891 28,406 22 77.4 1892 28,953 11 38.0 1892 29,601 20 67.6 1893 30,420 8 26.3 1893 30,796 20 64.9 1894 31,887 7 22.0 1894 31,991 17 53.1 1895 33,355 14 42.0 30.9 1895 1891-1895 33,185 26 78.3 1891-1895 152,101 47 153,979 105 68.2 1896 34,823 15 43.1 1896 34,379 24 69.8 1897 36,291 16 44.1 1897 35,573 26 73.1 1898 37,759 11 29.1 1898 36,767 30 81.6 1899 39,227 14 35.7 1899 37,961 29 76.4 1900 40,695 14 34.4 37.1 1900 1896-1900 39,155 36 91.9 1896-1900 188,795 70 183,835 145 78.9 1901 41,546 25 60.2 1901 40,210 42 104.5 1902 42,397 15 35.4 1902 41,265 23 55.7 1903 43,248 28 64.7 1903 42,320 42 99.2 1904 44,099 30 68.0 1904 43,375 43 99.1 1905 44,951 28 62.3 58.3 1905 1901-1905 44,429 54 121.5 1901-1905 216,241 126 211,599 204 96.4 1906 45,803 37 80.8 1906 45,484 33 72.6 1907 46,655 34 72.9 1907 46,539 64 137.5 1908 47,507 35 73.7 1908 47,594 42 88.2 1909 48,359 38 78.6 1909 48,649 60 123.3 1910 49,211 26 52.8 71.6 1910 1906-1910 49,704 68 136.8 1906-1910 237,535 170 237,970 267 112.2 (Calendar) (Calendar) 1911 50,063 35 69.9 1911 50,758 60 118.2 1912 50,915 51 100.2 1912 51,812 67 129.3 1913 51,767 59 114.0 1913 52,866 74 140.0 Source : Annual Reports of the Board of Health of the City of Hartford, Conn. Note: Data for 1886-1910 are for. fiscal Source : Annual Reports of the Board of Health of the City of Hartford, Conn. Note: Data for 1886-1910 are for fiscal years ending February 28th of following years ending February 28th of following year. year. 503 APPENDIX F {PART II) Table 69 Table 70 Mortality from Cancer in Mortality from Cancer in Hoboken, N, J. 1880-1913 Hoboken, N. J., by Sex - 1902-1913 Year (Ending Population Deaths from Rate per 100,000 June 30} Cancer Population MALES 1880 30,999 12 38.7 D eaths Rate per Year Population f rom 100,000 1881 32,343 14 43.3 C ancer Population 1882 33,687 10 29.7 1902 31,300 22 70.3 1883 35,031 17 48.5 1903 31,946 8 25.0 1884 36,376 10 27.5 1904 32,592 18 55.2 1885 37,721 19 50.4 40.0 1905 1902-1905 33,238 21 63.2 1881-1885 175,158 70 129,076 69 53.5 1886 1887 1888 1889 1890 38,906 40,091 41,276 42,462 43,648 17 • 22 20 28 19 43.7 54.9 48.5 65.9 43.5 51.4 1906 1907 1908 1909 1910 1906-1910 33,925 34,612 35,300 35,988 36,675 27 30 16 27 19 79.6 86.7 45.3 75.0 51.8 206,383 106 1886-1890 176,500 119 67.4 1891 45,735 20 43.7 1892 47,822 22 46.0 1911 37,363 20 53.5 1893 49,909 29 58.1 1912 38,051 21 55.2 1894 51,996 22 42.3 1913 38,739 21 54.2 1895 54,083 23 42.5 46.5 1902 FEMALES 30,505 17 1891-1895 249,545 116 55.7 1903 31,080 24 77.2 1896 55,139 25 45.3 1904 31,655 37 116.9 1897 56,195 45 80.1 1905 32,230 33 102.4 1898 57,251 28 48.9 1899 58,307 27 46.3 1902-1905 125,470 111 88.5 1900 59,364 30 50.5 54.1 1906 1907 32,514 32,798 43 22 132.3 1896-1900 286,256 155 67.1 (Calendar^ 1908 33,081 28 84.6 1901 60,584 32 52.8 1909 33,364 27 80.9 1902 61,805 39 63.1 1910 33,649 37 110.0 1903 63,026 32 50.8 1904 64,247 55 85.6 1906-1910 165,406 157 94.9 1905 65,468 54 82.5 1911 1912 33,933 34,217 38 37 112.0 108.1 1901-1905 315,130 212 67.3 1913 34,501 27 78.3 1906 66,439 70 105.4 1907 67,410 52 77.1 Source : Annual Reports of the Board of 1908 68,381 44 64.3 Health of the State of New Jersey. 1909 69,352 54 77.9 1910 70,324 56 79.6 80.7 1906-1910 341,906 276 1911 71,296 58 81.4 1912 72,268 58 80.3 1913 73,240 48 65.5 Source : Annual Reports of the Board of Health of the State of New Jersey. 504 APPENDIX F {PART II) Table 71 Mortality from Cancer in Indianapolis, Ind. 1900-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1900 169,164 108 63.8 1911 240,098 193 80.4 1912 246,546 216 87.6 1901 175,612 85 48.4 1913 252,994 222 87.7 1902 182,060 97 53.3 1903 188,508 106 56.2 Source: 1913 Annual Report of Depart- 1904 194,956 122 62.6 ment of Public Health and Charities of 1905 201,405 102 50.6 54.3 Indianapolis, Ind. 1901-1905 942,541 512 1906 207,854 110 52.9 1907 214,303 132 61.6 1908 220,752 156 70.7 1909 227,201 198 87.1 1910 233,650 181 77.5 70.4 1906-1910 1,103,760 777 Table 72 Mortality from Cancer in Indianapolis, Ind., by Sex 1906-1913 MALES FEMALES Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1906 103,049 33 32.0 1906 104,805 77 73.5 1907 106,304 41 38.6 1907 107,999 91 84.3 1908 109,559 49 44.7 1908 111,193 107 96.2 1909 112,814 62 55.0 1909 114,387 136 118.9 1910 116,069 50 43.1 42.9 1910 1906-1910 117,581 131 111.4 1906-1910 547,795 235 555,965 542 97.5 1911 1912 1913 119,323 122,577 125,831 76 67 72 63.7 54.7 57.2 1911 1912 1913 120,775 123,969 127,163 117 149 150 96.9 120.2 118.0 Source: Annual Reports of Department of Public Health and Charities of Indian- apolis, Inc 505 APPENDIX F (PART II) Table 73 Mortality from Cancer in Jersey City, N. J. 1879-1913 Year Deaths Rate per Deaths Rate per (Ending Population from 100,000 Year Population from 100,000 June 30) Cancer Population Cancer Population 1879 118,423 39 32.9 1906 239,715 138 57.6 1880 120,722 35 29.0 1907 246,731 159 64.4 1908 253,747 141 55.6 1881 127,280 56 44.0 1909 260,763 153 58.7 1882 133,838 37 27.6 1910 267,779 176 65.7 1883 140,396 48 34.2 1884 146,954 61 41.5 1906-1910 1,268,735 767 60.5 1885 153,513 52 33.9 1911 274,795 181 65.9 1«81-1885 701,981 254 36.2 1912 281,811 187 66.4 1913 288,827 195 67.5 1886 155,411 67 43.1 1887 157,309 59 37.5 Source : Annual Reports of the Board of 1888 159,207 69 43.3 Health of the State of New Jersey. 1912- 1889 161,105 60 37.2 1913 Reports of Vital Statistics— Board of 1890 163,003 80 49.1 42.1 Health — Hudson County; N. J. 1886-1890 796,035 335 1891 166,945 82 49.1 1892 170,887 92 53.8 1893 174,829 68 38.9 1894 178,771 77 43.1 1895 182,713 67 36.7 44.2 1891-1895 874,145 386 1896 187,457 94 50.1 . 1897 192,201 77 40.1 1898 196,945 89 45.2 1899 201,689 89 44.1 1900 206,433 85 41.2 44.1 1896-1900 984,725 434 (Calendar) 1901 211,686 105 49.6 1902 216,939 104 47.9 1903 222,192 126 56.7 1904 227.445 114 50.1 1905 232,699 142 61.0 53.2 1901-1905 1,110,961 591 506 APPENDIX F {PART II) Table 74 Mortality from Cancer in Jersey City, N. J. 1902-1913 by Sex MALES FEMALES Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1902 109,004 41 37.6 1902 107,935 63 58.4 1903 111,493 43 38.6 1903 110,699 83 75.0 1904 113,982 44 38.6 1904 113,463 70 61.7 1905 116,471 44 37.8 38.1 1905 1902-1905 116,228 98 84.3 1902-1905 450,950 172 448,325 314 70.0 1906 120,668 49 40.6 1906 119,047 89 74.8 1907 124,865 63 50.5 1907 121,866 96 78.8 1908 129,062 60 46.5 1908 124,685 81 65.0 1909 133,259 56 42.0 1909 127,504 97 76.1 1910 137,457 55 40.0 43.9 1910 1906-1910 130,322 121 92.8 1906-1910 645,311 283 623,424 484 77.6 1911 141,655 78 55.1 1911 133,140 103 77.4 1912 145,853 66 45.3 1912 135,958 121 89.0 1913 150,051 71 47.3 1913 138,768 124 89.4 Source: Annual Reports of the Board of Health of the State of New Jersey. Table 75 Mortality from Cancer in Kansas City, Mo. 1900-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1900 163,752 65 39.7 1906 214,529 148 69.0 1907 222,992 153 68.6 1901 172,214 78 45.3 1908 231,455 141 60.9 1902 180,677 101 55.9 ^ 1909 239,918 179 74.6 1903 189,140 96 50.8 1910 248,381 202 81.3 1904 197,603 206,066 128 110 64.8 53.4 54.2 1905 1906-1910 1911 1,157,275 256,843 823 236 71.1 1901-1905 945,700 513 91.9 1912 265,306 223 84.1 1913 27^,768 237 86.6 Source: United Stat 38 Mortality Sta- tistics. 507 APPENDIX F {PART II) Table 76 Mortality from Cancer in Los Angeles, Cal. 1900-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Caacer Population Cancer Population 1900 102,479 92 89.8 1906 232,510 217 93.3 1907 254,182 223 87.7 1901 124,150 111 89.4 1908 275,854 245 88.8 1902 145,822 119 81.6 1909 297,526 286 96.1 1903 167,494 146 87.2 1910 319,198 338 105.9 1904 189,166 117 61.9 1905 210,838 175 83.0 79.8 1906-1910 1911 1,379,270 340,869 1,309 328 94.9 1901-1905 837,470 668 96.2 1912 362,541 413 113.9 1913 384,212 425 110.6 Source: United States Mortality Sta- tistics. Table 77 Mortality from Cancer in Louisville, Ky. 1890-1913 Year Deaths Rate per Year Deaths Rate per (Endintf Population from 100,000 Population from 100,000 August 'jl) Cancer Population August 31) Cancer Population 1890 161,129 82 50.9 1906 216,248 129 59.7 1907 218,168 110 50.4 1891 165,489 84 50.8 1908 220,088 155 70.4 .1892 169,849 85 50.0 1909 222,008 126 56.8 1893 174,209 93 53.4 1910 223,928 153 68.3 1894 178,569 99 55.4 1895 182,929 95 51.9 52.4 1906-1910 1911 1,100,440 225,847 673 163 61.1 1891-1895 871,045 456 72.2 1912 227,766 152 66.7 1896 187,289 92 49.1 1913 229,685 165 71.8 1897 191,649 84 43.8 1898 196.009 124 63.3 Source: Annual Reports of the Health 1899 200,370 105 52.4 OfBcer of the City of Louisville, Ky. 1900 204,731 121 59.1 53.7 1896-1900 980,048 526 1901 206,650 109 52.7 1902 208,569 127 60.9 1903 210,488 114 54.2 1904 212,408 125 58.8 1905 214,328 127 59.3 57.2 1901-1905 1,052,443 602 508 APPENDIX F {PART II) Table 78 Mortality from Cancer in Memphis, Tenn. 1891-1914 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1891 68,277 16 23.4 1901 105,198 36 34.2 1892 72,059 21 29.1 1902 108,076 38 35.2 1893 75,841 12 15.8 1903 110,954 51 46.0 1894 79,623 15 18.8 1904 113,832 35 30.7 1895 83,405 19 22.8 21.9 1905 1901-1905 116,710 43 36.8 1891-1895 379,205 83 554,770 203 36.6 1896 87,188 16 18.4 1906 119,589 55 46.0 1897 90,971 21 23.1 1907 122,468 57 46.5 1898 94,754 29 30.6 1908 125,347 67 53.5 1899 1909 128,226 53 41.3 1900 102,320 47 45.9 30.1 1910 1906-1910 131,105 73 55.7 1896-1900 375,233 113 626,735 305 48.7 1911 133,983 64 47.8 1912 136,861 76 65.5 1913 139,739 61 43.7 1914 142,617 110 77.1 Source: Annual Reports of the Board of Health of the City of Memphis, Tenn. Table 79 Mortality from Cancer in Memphis, Tenn., White 1891-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 37,427 7 18.7 1901 55,001 16 29.1 1892 39,088 14 35.8 1902 57,622 22 38.2 1893 40,749 9 22.1 1903 60,243 41 68.1 1894 42,410 10 23.6 1904 62,864 29 46.1 1895 44,071 13 29.5 26.0 1905 1901-1905 65,485 30 45.8 1891-1895 203,745 53 301,215 138 45.8 1896 45,732 9 19.7 1906 68,106 43 63.1 1897 47,394 17 35.9 1907 70,727 • 38 53.7 1898 49,056 23 46.9 1908 73,348 47 64.1 1899 1909 75,969 38 50.0 1900 52,380 32 61.1 41.6 1910 1906-1910 78,590 51 64.9 1896-1900 194,562 81 366,740 217 59.2 1911 81,211 40 49.3 1912 8.3,832 45 53.7 1913 86,453 35 40.5 1914 89,074 85 95.4 Source: Annual Reports of the Board of Health of the City of Memphi.s, Tenn. 509 APPENDIX F {PART II) Table 80 Mortality from Cancer in Memphis, Tenn., Colored 1891-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 30,850 9 29.2 1901 50,197 20 39.8 1892 32,971 7 21.2 1902 50,454 16 31.7 1893 35,092 3 8.5 1903 50,711 10 19.7 1804 37,213 5 13.4 1904 50,968 6 11.8 1895 39,334 6 30 15.3 17.1 1905 1901-1905 51,225 13 65 25.4 1891-1895 175,460 253,555 25.6 1896 41,456 7 16.9 1906 51,483 12 23.3 1897 43,577 4 9.2 1907 51,741 19 36.7 1898 45,698 6 13.1 1908 51,999 20 38.5 1899 1909 52,257 15 28.7 1900 49,940 15 32 30.6 17.7 1910 1906-1910 52,515 22 88 41.9 1896-1900 180,671 259,995 33.8 1911 52,772 24 45.5 1912 53,029 31 58.5 1913 53,286 26 48.8 1914 53,543 25 46.7 Source: Annual Reports of the Board of Health of the City of Memphis , Tenn. Table 81 Mortality from Cancer in Milwaukee, Wis. 1894-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1894 240,325 107 44.5 1906 325,129 234 72.0 1895 249,290 149 59.8 1907 337,311 230 68.2 1908 349,493 218 62.4 1896 256,495 160 62.4 1909 361,675 259 71.6 1897 263,700 164 62.2 1910 373,857 254 67.9 1898 270,905 166 61.3 1899 278,110 194 69.8 1906-1910 1,747,465 1,195 68.4 1900 285,315 196 68.7 1911 386,038 278 72.0 1896-1900 1,354,525 880 65.0 1912 398,219 283 71.1 1913 410,400 287 G9.9 1901 290,841 206 70.8 1902 296,367 208 70.2 Source: Annual Reports of the Com- 1903 301,894 212 70.2 missioner of Health of the City of Milwau- 1904 307,421 224 72.9 kee. Wis. 1905 312,948 206 65.8 70.0 1901-1905 1,509,471 1,056 510 APPENDIX F (PART II) Table 82 Mortality from Cancer in Milwaukee, Wis., Males 1898 -1913 Deaths Rate per Deaths Rate per Year Population from 100,000 lear Population from 100,000 Cancer Population Cancer Population 1898 133,460 74 55.4 1906 162,939 106 65.1 1899 136,998 95 69.3 1907 169,576 93 54.8 1900 140,536 72 51.2 1908 176,213 99 56.2 1909 182,850 107 58.5 1898-1900 410,994 143,689 241 92 58.6 64.0 1910 1906-1910 189,488 120 525 63.3 1901 881,066 59.6 1902 146,842 87 59.2 1903 149,995 91 60.7 1911 196,125 124 63.2 1904 153,148 103 67.3 1912 202,762 118 58.2 1905 156,302 95 468 60.8 62.4 1913 Source: 209,399 120 Annual Reports of 57.3 1901-1905 749,976 the Com- missioner of Health of the City of Milwau- kee, Wis. Table 83 Mortality from Cancer in Milwaukee, Wis., Females 1898-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1898 137,445 92 66.9 1906 162,190 128 78.9 1899 141,112 99 70.2 1907 167,735 137 81.7 1900 144,779 124 85.6 1908 173,280 119 68.7 1909 178,825 152 85.0 1898-1900 423,336 147,152 315 114 74.4 77.5 1910 1906-1910 184,369 134 670 72.7 1901 866,399 77.3 1902 149,525 121 80.9 1903 151,899 121 79.7 1911 189,913 154 81.1 1904 154,273 121 78.4 1912 195,457 165 84.4 1905 156,646 111 588 70.9 77.4 1913 Source: 201,001 167 Annual Reports of 83.1 1901-1905 759,495 the Com- missioner Df Health of th e City Df Milwau- kee. Wis. 511 APPENDIX F {PART II) Table 84 Mortality from Cancer in Minneapolis, Minn. 1889-1913 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1889 152,952 76 49.7 1901 212,587 133 62.6 1890 164,738 68 41.3 1902 222,456 117 52.6 1903 232,325 154 66.3 1891 168,536 61 36.2 1904 242,194 140 57.8 1892 172,334 79 45.8 1905 252,063 162 64.3 1893 176.132 84 47.7 1894 179,930 91 50.6 1901-1905 1,161,625 706 60.8 1895 183,728 82 44.6 1906 261,932 171 65.3 1891-1895 880,660 397 45.1 1907 271,801 189 69.5 1908 281,670 179 63.5 1896 187,526 103 54.9 1909 291,539 186 63.8 1897 191,324 91 47.6 1910 301,408 195 64.7 1898 195,122 106 54.3 1899 198,920 95 47.8 1906-1910 1,408,350 920 65.3 1900 202,718 120 59.2 1911 311,277 234 75.2 1896-1900 975,610 515 52.8 1912 321,146 258 80.3 J913 331,015 276 83.4 Source: Annual Reports of the Depart- ment of Health of the City of Minneapolis, Minn. Table 85 Mortality from Cancer in Minneapolis, Minn., by Organs and Parts according to Sex, 1908-1912 TOTAL MALES FEMALES Deaths Rate per Deaths Rate per Deaths Rate per Organ or Part from 100,000 from 100,000 from 100,000 Cancer Population Cancer Population Cancer Population Buccal cavity 40 2.7 34 4.3 6 0.8 Stomach and liver 421 27.9 244 31.0 177 24.6 Peritoneum, intestines, rectum 121 8.0 58 7.4 63 8.7 Female generative organs 144 9.6 144 20.0 Breast 102 6.8 i o.i 101 14.0 Skin 32 2.1 20 2.5 12 1.7 Other or not specified organs. . 192 12.7 69.8 116 473 14.8 60.1 76 579 10.6 All organs 1,052 80.4 Source: Minn. Annual Reports of the Department of Health of the City of Minneapolis, 512 APPENDIX F {PART II) Table 86 Mortality from Cancer in Minneapolis, Minn., by Organs and Parts according to Age, 1908-1912 Organ or Part Buccal cavity Stomach and liver Peritoneum, intestines, rectum Female generative organs Breast Skin Other or not specified organs. . All organs UNDER 40 Deaths Rate per 100,000 Population 0.2 from Cancer 2 27 17 16 10 5 36 113 2.4 1.5 1.4 0.9 0.5 3.2 10.1 40-59 Deaths Rate per from 100,000 Cancer Population 16 189 40 88 56 5 78 472 5.4 64.2 13.6 29.9 19.0 1.7 26.5 160.3 60 AND OVER Deaths from Cancer 205 40 36 78 467 Rate per 100,000 Population 25.3 235.4 73.5 45.9 41.3 25.3 89.4 536.1 Source: Annual Reports of the Department of Health of the City of Minneapolis, Minn. Table 87 Mortality from Cancer in Nashville, Tenn. 1879-1914 Year Deaths Rate per Deaths Rate per (Ending Population from 100,000 Year Population from 100,000 Sept. 30) Cancer Population (C:llendar) Cancer Population 1879 41,601 6 14.4 1896 78',985 42 53.2 1880 43,350 9 20.8 1897 79,455 29 36.5 1898 79,925 40 50.0 1881 46,631 9 19.3 1899 80,395 53 65.9 1882 49,912 15 30.1 1900 80,865 27 33.4 1883 53,194 8 15.0 1884 56,476 16 28.3 1896-1900 399,625 191 47.8 1885 59,758 12 20.1 1901 83,814 49 58.5 1881-1885 265,971 60 22.6 1902 86,764 36 41.5 1903 89,714 44 49.0 1886 63,040 11 17.4 1904 92,664 51 55.0 1887 66,322 9 13.6 1905 95,614 55 57.5 1888 69,604 14 20.1 1889 72,886 14 19.2 1901-1905 448,570 235 52.4 1890 76,168 19 24.9 1906 98,564 61 61.9 1886-1890 348,020 67 19.3 1907 101,514 74 72.9 (Calendar) 1908 104,464 78 74.7 1891 76,637 23 30.0 1909 107,414 69 64.2 1892 77,106 23 29.8 1910 110,364 73 66.1 1893 77,575 28 36.1 1894 78,045 27 34.6 1906-1910 522,320 355 68.0 1895 78,515 38 48.4 1911 113,314 81 71.5 1891-1895 387,878 139 35.8 1912 116,264 76 65.4 1913 119,214 86 72.1 1914 122,165 94 76.9 Source: Annual Reports of the Health Officer of the City of Nashville, Tenn. 513 APPENDIX F (PART II) Table 88 Table 89 Mortality from Cancer in Nashville, Mortality from Cancer in Nashville, Tenn., Males, 1885-1< >13 Rate per Teni Year ti., Females , 1885-1 Deaths 913 Year Deaths Rate per (Ending Population from 100,000 (Ending Population from 100,000 Sept. 30) Cancer Population Sept. 30) Cancer Population 1885 29,171 3 10.3 1885 30,587 9 29.4 1886 30,716 3 9.8 1886 32,324 8 24.7 1887 , , 1887 1888 33,786 2 5'.9 1888 35,8i8 ik 33.5 1889 35,312 2 5.7 1889 37,574 12 31.9 1890 36,832 7 19.0 10.2 1890 1886-1890 39,336 12 30.5 1886-1890 136,646 14 145,052 44 30.3 (Calendar) (Calendar) 1891 36,984 6 16.2 1891 39,653 17 42.9 1892 37,136 5 13.5 1892 39,970 18 45.0 1893 37,288 8 21.5 1893 40,287 20 49.6 1894 37,440 6 16.0 1894 40,605 21 51.7 1895 37,592 8 33 21.3 17.7 1895 1891-1895 40,923 30 73.3 1891-1895 186,440 201,438 106 52.6 1896 37,744 8 21.2 1896 41,241 34 82.4 1897 37,897 7 18.5 1897 41,558 22 52.9 1898 38,050 8 21.0 1898 41,875 32 76.4 1899 38,203 . 11 28.8 1899 42,192 42 99.5 1900 38,356 9 23.5 22.6 1900 1896-1900 42,509 18 42.3 1896-1900 190,250 43 209,375 148 70.7 1901 39,735 15 37.8 1901 44,079 34 77.1 1902 41,115 11 26.8 1902 45,649 25 54.8 1903 42,495 12 28.2 1903 47,219 32 67.8 1904 43,875 19 43.3 1904 48,789 32 65.6 1905 45,255 18 39.8 35.3 1905 1901-1905 50,359 37 73.5 1901-1905 212,475 75 236,095 160 67.8 1906 46,635 14 30.0 1906 51,929 47 90.5 1907 48,015 27 56.2 1907 53,499 47 87.9 1908 49,395 20 40.5 1908 55,069 58 105.3 1909 50,775 13 25.6 1909 56,639 5Q 98.9 1910 52,155 20 38.3 38.1 1910 1906-1910 58,209 53 91.1 1906-1910 246,975 94 275,345 261 94.8 1911 53,535 25 46.7 1911 59,779 56 93.7 1912 54,915 14 25.5 1912 61,349 62 101.1 1913 56,295 30 63.3 1913 62,919 56 89.0 Source: Annual Reports of the Health OfBcer of the City of Nashville, Tenn. Source: Annual Reports of the Health Officer of the City of Nashville, Tenn. 514 APPENDIX F {PART II) Table 90 Mortality from Cancer in Nashville, Tenn., White 1885-1914 Year (Ending SeiH. 30) Population Deaths from Cancer Rate per 100,000 Population 1885 36,888 6 16.3 1886 38,865 8 20.6 1887 1888 42,819 io 23.4 1889 44,796 9 20.1 1890 46,773 13 27.8 1886-1890 173,253 40 23.1 (Calendar) 1891 47,175 20 42.4 1892 47,577 20 42.0 1893 47,979 19 39.6 1894 48,381 14 28.9 1895 48,783 25 51.2 1891-1895 239,895 98 40.9 1896 49.185 29 59.0 1897 49,587 17 34.3 1898 49,990 26 52.0 1899 50,393 28 55.6 1900 50,796 17 33.5 1896-1900 249,951 117 46.8 1901 53,099 33 62.1 1902 55,402 21 37.9 1903 57,705 27 46.8 1904 60,008 39 65.0 1905 62,311 46 73.8 1901-1905 £88,525 166 57.5 1906 64,615 38 58.8 1907 66.919 57 85.2 1908 69,223 5Q 80.9 1909 71,527 49 68.5 1910 73,831 58 78.6 1906-1910 346,115 258 74.5 1911 76,135 65 85.4 1912 78,438 56 71.4 1913 80,742 73 90.4 1914 83,047 66 79.5 Source: Annual Reports of the Health Officer of the City of Nashville, Tenn. 515 APPENDIX F (PART II) Table 91 Mortality from Cancer in Nashville, Tenn., Colored 1885-1914 Year Deaths Rate per Deaths Rate per (Ending Population from 100,000 Year Population from 100,000 Sept. 30) Cancer Population (Calendar) Cancer Population 1885 22,870 6 26.2 1901 30,715 16 52.1 1902 31,362 15 47.8 1886 24,175 3 12.4 1903 32,009 17 53.1 1887 1904 32,656 12 36.7 1888 26,785 '4 14.9 1905 33,303 9 27.0 1889 28,090 5 17.8 1890 29,395 6 18 20.4 16.6 1901-1905 1906 160,045 33,949 69 23 43.1 1886-1890 108,445 67.7 (Calendar) 1907 34,595 17 49.1 1891 29,462 3 10.2 1908 35,241 22 62.4 1892 29,529 3 10.2 1909 35,887 20 55.7 1893 29,596 9 30.4 1910 36,533 15 41.1 1894 29,664 13 43.8 1895 29,782 13 41 43.7 27.7 1906-1910 1911 176,205 37,179 97 16 55.0 1891-1895 147,983 43.0 1912 37,826 20 52.9 1896 29,800 13 43.6 1913 38,472 13 33.8 1897 29,868 12 40.2 1914 39,118 28 71.6 1898 29,935 14 46.8 1899 30,002 25 83.3 Source: Annual Reports of the Health 1900 30,069 10 74 33.3 49.4 Officer of the City of Nashville, Tenn. 1896-1900 149,674 Table 92 Mortality from Cancer in Nashville, Tenn., by Organs and Parts according to Sex, 1903-1912 TOTAL Organ or Part Buccal cavity -. Stomach and liver Peritoneum, intestines, rectum Female generative organs Breast Skin Other or not specified organs. . Deaths from Cancer 29 180 71 184 74 19 105 Rate per 100,000 Population 2.8 17.5 6.9 17.9 7.2 1.8 10.2 MALES Deaths Rate per from 100,000 Cancer Popiilation 20 4.1 67 13.8 24 4.9 10 61 2.1 12.5 FEMALES Deaths Rate per from 100,000 Cancer Population 9 113 47 184 74 9 44 1.7 20.8 8.7 33.9 13.6 1.7 8.0 All organs 662 64.3 182 37.4 480 88.4 Source: Annual Reports of the Health Officer of the City of Nashville, Tenn. 516 APPENDIX F {PART II) Table 93 Mortality from Cancer in Newark, N. J. 1859-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population (Calendar) Cancer Population 1859 67,895 17 25.0 1891 188,625 98 52.0 1860 71,941 9 12.5 1892 195,420 117 59.9 1861 75,035 11 14.7 1893 202,215 101 49.9 1862 1894 209,010 134 64.1 1863 81,223 12 14.8 1895 215,806 126 58.4 1864 1865 84,318 11 13.0 15.8 1891-1895 1896 1,011,076 221,858 576 140 57.0 1859-1865 380,412 60 63.1 1897 227,911 122 53.5 1866 90,942 15 16.5 1898 233,964 130 55.6 1867 94,471 21 22.2 1899 240,017 135 56.2 1868 1900 246,070 159 64.6 1869 1870 101,529 105,059 22 20 21.7 19.0 19.9 1896-1900 1901 1,169,820 253,513 686 171 58.6 1866-1870 392,001 78 67.5 1902 260,957 150 57.5 1871 108,709 23 21.2 1903 268,401 178 66.3 1872 112,359 31 27.6 1904 275,845 174 63.1 1873 116,009 42 36.2 1905 283,289 189 66.7 1874. 119,659 123,310 46 25 38.4 20.3 28.8 XO 1 T! 1875 1901-1905 1906 1,342,005 296,125 862 209 64.2 1871-1875 580,046 167 70.6 1907 308,961 249 80.6 1876 125,949 48 38.1 1908 321,797 229 71.2 1877 128,588 50 38.9 1909 334,633 264 78.9 1878 131,228 70 53.3 1910 347,469 286 82.3 (Ending June 30) 1879 133,868 57 42.6 1906-1910 1,608,985 1,237 76.9 1880 136,508 62 45.4 1911 360,305 373,141 275 76.3 1876-1880 656,141 287 43.7 1912 299 80.1 1913 385,977 303 78.5 1881 139,804 61 43.6 1882 143,100 58 40.5 Source: Annual Reports of the Board of 1883 146,396 60 41.0 Health of the State of New Jersey. 1884 149,692 82 54.8 1885 152,988 80 62.3 46.6 1881-1885 731,980 341 1886 158,756 91 57.3 • 1887 164,524 91 55.3 1888 170,292 94 55.2 . 1889 176,061 91 51.7 1890 181,830 85 46.7 53.1 1886-1890 851,463 452 517 APPENDIX F {PART II) Table 94 Table 95 Mortality from Cancer in Mortality from Cancer in Newark, N, J., by Sex Vew Haven, Conn. 1902-1913 1884)- 19 13 Deaths MALES Rate per Year Population from 100,000 Deaths Rate per Cancer Population Year Population from 100,000 Cancer Population 1880 62,882 37 58.8 1902 128,647 43 33.4 • 1881 64,723 43 66.4 1903 132,458 67 50.6 1882 66,564 31 46.6 1904 136,269 63 46.2 1883 68,405 40 58.5 1905 140,080 68 48.5 1884 1885 70,246 72,088 40 30 56.9 41.6 1902-1905 537.454 241 44.8 1881-1885 342,026 184 53.8 1906 146,741 64 43.6 1907 153,403 92 60.0 1886 73,930 48 64.9 1908 160,065 83 51.9 1887 75,772 48 63.3 1909 166,727 100 60.0 1888 77,614 40 51.5 1910 173,389 98 56.5 1889 79,456 39 49.1 1890 81,298 39 48.0 1906-1910 800,325 437 54.6 1886-1890 388,070 214 55.1 1911 180,051 98 54.4 1912 186,713 114 61.1 1891 83,970 35 41.7 1913 193,375 129 66.7 1892 86,643 53 61.2 1893 89,316 47 52.6 FE1L\LES 1894 91,989 54 58.7 1895 94,662 60 63.4 1902 1903 132,310 135,943 107 80.9 111 81.7 1891-1895 446,580 249 55.8 1904 139,576 111 79.5 1905 143,209 121 84.5 1896 97,335 60 61.6 1897 100,008 64 64.0 1902-1905 551,038 450 81.7 1898 102,681 71 69.1 1899 105,354 74 70.2 1906 149,384 145 97.1 1900 108,027 71 65.7 1907 155,558 157 100.9 1908 161,732 146 90.3 1896-1900 513,405 340 66.2 1909 167,906 164 97.7 1901 110,584 98 88.6 1910 174,080 188 108.0 ■ 1902 113,141 87 76.9 1903 115,699 90 77.8 1906-1910 808,060 800 98.9 1904 118,257 81 68.5 1905 120,815 110 91.0 1911 180,254 177 98.2 1912 186,428 185 99.2 1901-1905 578,496 466 80.6 1913 192,602 174 90.3 1906 123,373 98 79.4 Source: Annual Renort 5 of the Board of 1907 125,931 109 86.6 Health of the State of New Jersey. 1908 128,489 129 100.4 1909 131,047 119 90.8 1910 1906-1910 133,605 122 91.3 642,445 577 89.8 1911 136,163 112 82.3 1912 138,721 134 96.6 1913 141,279 127 89.9 Source : Annual Reports of the Board of Health of the City of New Haven, Conn. 518 APPENDIX F {PART II) Table 96 Mortality from Cancer in New Haven, Conn., Males 1880-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1880 31,213 8 25.6 1906 61,552 1907 62,837 35 44 56.9 70.0 1881 32,135 14 43.6 1908 64,123 61 95.1 1882 33,057 10 30.3 1909 65,409 49 74.9 1883 33,979 10 29.4 1910 66,695 49 73.5 1884 34,901 11 31.5 1885 35,823 14 39.1 34.7 1906-1910 320,616 1911 67,981 238 37 74.2 1881-1885 169,895 59 54.4 1912 69,267 62 89.5 1886 36,745 16 43.5 1913 70,553 47 66.6 1887 37,668 15 39.8 1888 38,591 13 33.7 Source: Annual Reports of the Board of 1889 39,514 11 27.8 Health of the City of New Haven Conn. 1890 40,437 11 27.2 34.2 1886-1890 192,955 66 1891 41,777 11 26.3 1892 43,117 17 39.4 1893 44,457 18 40.5 1894 45,797 22 48.0 1895 47,137 16 33.9 37.8 ,;t 1891-1895 222,285 84 1896 48,478 23 47.4 1897 49,819 22 44.2 1898 51,160 23 45.0 1899 52,501 23 43.8 1900 53,842 32 59.4 48.1 1896-1900 255,800 123 1901 55,127 37 67.1 1902 56,412 27 47.9 1903 57,697 29 50.3 1904 58,982 24 40.7 1905 60,267 46 76.3 56.5 1901-1905 288,485 163 519 APPENDIX F (PART II) Table 97 Mortality from Cancer in New Haven, Conn. 1880-1913 Females Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1880 31.669 29 91.6 1906 61,821 63 101.9 1907 63,094 65 103.0 1881 32,588 29 89.0 1908 64,366 68 105.6 1882 33,507 21 62.7 1909 65,638 70 106.6 1883 34,426 30 87.1 1910 66,910 73 109.1 1884 35,345 29 82.0 1885 36,265 16 44.1 72.6 1906-1910 1911 321,829 68,182 339 75 105.3 1881-1885 172,131 125 110.0 1912 69,454 72 103.7 1886 37,185 32 86.1 1913 70,726 80 113.1 1887 38,104 33 86.6 1888 39,023 27 69.2 Source: Annual Reports of the Board of 1889 39,942 28 70.1 Health of the City of New Haven, Conn. 1890 40,861 28 68.5 75.9 1886-1890 195,115 148 1891 42,193 24 56.9 1892 43,526 36 82.7 . 1893 44,859 29 64.6 1894 46,192 32 69.3 18^5 47,525 44 92.6 73.6 1891-1895 224,295 165 1896 48,857 37 75.7 1897 50,189 42 83.7 1898 51,521 48 93.2 1899 52,853 51 96.5 1900 54,185 39 72.0 84.2 1896-1900 257,605 217 1901 55,457 61 110.0 1902 56,729 60 105.8 1903 58,002 61 105.2 1904 59,275 57 96.2 1905 60,548 64 105.6 104.5 1901-1905 290,011 303 520 APPENDIX F (PART II) Table 98 Mortality from Cancer in New Orleans, La. 1871-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1871 193,753 90 46.5 1901 292,301 206 70.5 1872 196,117 90 45.9 1902 297,498 214 71.9 1873 198,509 94 47.4 1903 302,695 235 77.6 1874 200,931 87 43.3 1904 307,892 252 81.8 1875 203,382 89 43.8 45.3 1905 1901-1905 313,089 261 83.4 1871-1875 992,692 450 1,513,475 1,168 77.2 1876 205,863 91 44.2 1906 318,286 247 77.6 1877 208,375 114 54.7 1907 323,483 269 83.2 1878 210,917 115 54.5 1908 328,680 270 82.1 1879 214,490 105 49.0 1909 333,877 280 83.9 1880 216,090 129 59.7 52.5 1910 1906-1910 339,075 285 84.1 1876-1880 1,055,735 554 1,643,401 1,351 82.2 1881 218,571 127 58.1 1911 344,273 277 80.5 1882 221,045 143 64.7 1912 349,471 328 93.9 1883 223,565 122 54.6 1913 354,669 330 93.0 1884 226,114 151 66.8 1914 359,867 349 97.0 1885 228,692 138 60.3 Source: 1871-1899, Vital Statistics of 1881-1885 1,117,987 681 60.9 New Orleans, La., Annual Reports of the Board of Health of New Orleans, La. 1886 231,299 158 68.3 1887 233,936 147 62.8 1888 236,603 143 60.4 1889 239,300 132 55.2 1890 242,039 190 78.5 65.1 1886-1890 1,183,177 770 1891 246,545 158 64.1 1892 251,051 168 66.9 1893 255,557 172 67.3 1894 260,063 174 66.9 1895 264,569 188 71.1 67.3 1891-1895 1,277,785 860 1896 269,076 139 51.7 1897 273,583 183 66.9 1898 278,090 185 66.5 1899 282,597 171 60.5 1900 287,104 185 64.4 62.1 1896-1900 1,390,450 863 521 APPENDIX F (PART II) Table 99 Mortality from Cancer in New Orleans, La., White 1877-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1877 153,132 87 56.8 1901 212,991 146 68.5 1878 154,877 89 57.5 1902 217,036 166 76.5 1879 156,622 75 47.9 1903 221,081 174 78.7 1880 158,367 102 64.4 1904 225,127 186 82.6 56.7 1905 229,173 196 85.5 1877-1880 622,998 353 1901-1905 1,105,408 868 78.5 1881 160,267 88 54.9 1882 162,168 113 69.7 1906 233,219 183 78.5 1883 1907 237,265 201 84.7 1884 165,970 113 68.1 1908 241,311 210 87.0 1885 167,871 102 60.8 1909 245,357 223 90.9 1910 249,403 216 86.6 1881-1885 656,276 416 63.4 1906-1910 1,206,555 1,033 85.6 1886 169,772 110 64.8 1887 171,673 104 60.6 1911 253,449 208 82.1 1888 173,574 109 62.8 1912 257,495 242 94.0 1889 175,475 111 63.3 1913 261,541 242 92.5 1890 177,376 142 80.1 66.4 1914 Source: 265,587 1877-1899, 257 Vital Sta 96.8 1886-1890 867,870 576 tistics of New Orleans, La., Annual Reports of the 1891 180,533 118 65.4 Board of Health of New Orleans La. 1892 183,690 123 67.0 1893 186,847 128 68.5 1894 190,004 132 69.5 1895 193,161 134 69.4 68.0 1891-1895 934,235 635 1896 196,318 110 56.0 1897 199,475 145 72.7 1898 202,632 140 69.1 1899 205,789 131 63.7 1900 208,946 139 66.5 65.6 1896-1900 1,013,100 665 522 APPENDIX F {PART II) Table 100 Mortality from Cancer in New Orleans, La., Colored 1877-1914 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1877 55,243 27 48.9 1901 79,310 60 75.7 1878 56,040 26 46.4 1902 80,462 48 59.7 1879 57,868 30 51.8 1903 81,614 61 74.7 1880 57,723 27 46.8 1904 1905 82,765 83,916 66 65 79.7 77.5 1877-1880 226,874 110 48.5 1901-1905 408,067 300 73.5 1881 58,304 39 66.9 1882 58,877 30 51.0 1906 85,067 64 75.2 1883 1907 86,218 68 78.9 1884 60,144 38 63.2 1908 87,369 60 68.7 1885 60,821 36 59.2 1909 1910 88,520 89,672 57 69 64.4 76.9 1881-1885 238,146 143 fiO \J\J.\J 1906-1910 436,846 318 72.8 1886 61,527 48 78.0 1887 62,263 43 69.1 1911 90,824 69 76.0 1888 63,029 34 53.9 1912 91,976 86 93.5 1889 63,825 21 32.9 1913 93,128 88 94.5 1890 64,663 48 74.2 61.5 1914 Source: 94,280 1877-1899, 92 Vital Sta 97.6 1886-1890 315,307 194 tistics of New Orleans, La., Annual Reports of the 1891 66,012 40 60.6 Board of Health of New Orleans La. 1892 67,361 45 66.8 1893 68,710 44 64.0 1894 70,059 42 59.9 1895 71,408 54 225 75.6 65.5 1891-1895 343,550 1896 72,758 29 39.9 1897 74,108 38 51.3 1898 75,458 45 59.6 1899 76,808 40 52.1 1900 78,158 46 58.9 52.5 1896-1900 377,290 198 523 APPENDIX F {PART II) Table 101 Mortality from Cancer in New Orleans, La., by Sex 1901-1913 MALES Year Population Deaths from Cancer Rate per 100,000 Population 1901 1902 1903 1904 1905 138,785 141,502 144,219 146,936 149,653 89 72 79 90 93 64.1 50.9 54.8 61.3 62.1 1901-1905 721,095 423 58.7 1906 1907 1908 1909 1910 152,370 155,087 157,804 160,521 163,239 105 100 97 114 110 68.9 64.5 61.5 71.0 67.4 1906-1910 789,021 526 66.7 1911 1912 1913 165,957 168,675 171,393 FEMALES 101 158 139 60.9 93.7 81.1 1901 1902 1903 1904 1905 153,516 155,996 158,476 160,956 163,436 117 142 156 162 168 76.2 91.0 98.4 100.6 102.8 1901-1905 792,380 745 94.0 1906 1907 1908 1909 1910 165,916 168,396 170,876 173,356 175,836 142 169 173 166 175 85.6 100.4 101.2 95.8 99.5 1906-1910 854,380 825 96.6 1911 1912 1913 178,316 180,796 183,276 176 170 191 98.7 94.0 104.2 Source: Annual Reports of the Board of Health of New Orleans, La. 524 APPENDIX F {PART II) Table 102 Mortality from Cancer in New Orleans, La., by Organs and Parts according to Race, 1904-1913 TOTAL Deaths Rate per Organ or Part from 100,000 Cancer Population Buccal cavity 144 4.3 Stomach and liver 802 24.2 Peritoneum, intestines, rectum 214 6.5 Female generative organs 690 20.8 Breast 207 6.2 Skin 30 0.9 Other or not specified organs. . 712 21.6 Allorgans 2,799 84.5 2,107 86.6 WHITE COLORED Deaths Rate per Deaths Rate per from 100,000 from 100,000 Cancer Population Cancer Population 120 4.9 24 2.7 616 25.3 186 21.1 161 6.6 53 6.0 444 18.2 246 28.0 149 6.1 58 6.6 26 1.1 4 0.5 591 24.4 121 13.8 692 78.7 Source: Annual Reports of the Board of Health of the City of New Orleans, La. Table 103 Mortality from Cancer in New Orleans, La., by Organs and Parts according to Sex and Race, 1904-1913 Organ or Part Buccal cavity Stomach and liver Peritoneum, intestines, rectum Skin Other or not specified organs. . All organs Buccal cavity Stomach and liver Peritoneum, intestines, rectum Female generative organs Breast Skin Other or not specified organs. . MALES TOTAL Deaths Rate per from Cancer 111 427 100 21 448 100,000 Population 7.0 26.8 6.3 1.3 28.2 1,107 69.6 FEMALES 33 375 114 690 207 9 264 All organs 1,692 1.9 21.8 6.6 40.1 12.0 0.5 15.4 98.3 WHITE Deaths Rate per 100,000 Population 7.8 from Cancer 93 327 76 18 380 894 27.5 6.4 1.5 32.1 75.3 COLORED Deaths Rate per 100,000 Population 4.4 24.7 6.9 0.7 16.9 from Cancer 18 100 24 3 68 213 52.6 1,213 97.3 27 2.2 6 1.3 289 23.2 86 18.1 85 6.8 29 6.1 444 35.6 246 61.8 149 12.0 58 12.2 8 0.6 1 0.2 211 16.9 53 11.2 479 100.9 Source: Annual Reports of the Board of Health of the City of New Orleans, La. 525 APPENDIX F (PART II) a) 2 H o ya ,_i^<5<,— II— (I— It— I J3 t>'*l-«J'05'35t-^ a ,_ ^ i-H (J« i-H ^ SI ■># l-H O jj ^ (W t~ O ©* Ol »0 «3 g.-S r-<' si ^' 05 eo >c -^ • oiO'S'OOOoo dsisioodaJd 0-*'*»OOir5C£>0 •®(t--*<>Oi-li-iCCS< . o t- o >c • '3' 1— I S<5 05 o a si i> -^ ■* »c CO CO l-H I-H I-l ©< S* S< S* rjl t- S» • • i-i o i-i t~ • -* rH SI 1-1 ■ >0 SO i-i o "o -# U S SI l« i-H O • O O i> SI o CO r-l ,-1 ■ d CO »0 i-l <0 I— iGOCOSIlOt-CO I? ojodcoioi^oico CO O 1> 05 CO I-l SI !— I I-l i# CO «0 SI CO r-l 1-1 rH rH SI • sisicocor-^siajsi 'ocosidddi-HO ©I St »C CO o d si d © «5 SI 00 CO •* o 05 M « = o w 3 !s 9 0-2 5 ^-° J 526 APPENDIX F {PART II) c « o 2 o 3 ^ (3 XJ <« i-a I ^•^COOOcqO -t^OOSt-; i-H -t^-'Ol^ ■■-fi-'S50 S .ti CO o d d d ■ d d -p d d " i-^ ' ■* d " ' 'rj • • rx" d 0a<«»»«'5<>0 i-l»Or-lr-c >-( rH rl rt ^O Q T-'« '"' a ol "■ '~' u ^ '^ Or> 7-1 to <-^ ._i,_iOr-l Ol .^.pHS« ••'^••CO^I a o< • f-H 3 Z; "o-a *: ^ i> o O 05 Ot-;qO»l^ 05 05'5»--f;t-; OCO-O- u* £.ti d d d »o d d d rt' d d o< -li ■ d ^ d ' d ' ' o< ' K O a «o 'J" "o '«< Oi-HtO'O'-i C« rflCOOO'*" 0»0 Tf< < u'O r-< a a/< o Ch^ H hi J3 00 0< l-H I-l 1— 1 l-H 1— 1 Ol >— o eo-t~--co-l a -1 CO o< • 1 "o-o ^ o . . . O C . i> • -^ C c i-H p ■ eo CO o ■ >* o CO '^ -1 S.ti • • -tec ■ d ■ o< c ir i> d ■ i> c o «o o CO -^ o o a 1^ «^ «3 ©< jfl ®) «5 * •^ i-H • O •* i-C . »» rl rl r-l -1 a • • • • CO o< ■ 3 Z «*-! OT3 5^ .u- ij • • • C • 'O O 00 c p • T^ ■ 1> • ■ H g.^ • • -00 * ■ ■ 1-1 «: IT • ,_<■ d r-n' CC d ■ lo ■ d ■ ^ u a I— 1 1— S) o« o so IX r-1 CO H i-"^ I-H H s< H Bi Pi -t; P PL| o b .| . . .<« . . -o — ■ l-l l> >- rH • c s» ■* a^ r-( ?0 S< -fl «c «c t- OS i-H 0» -i) «5 • CO rH 50 t~ rH a r-( »< t- . "5 t- o< — 3 rH z ^ K o o H O & > '9 03 g 1 V <1 . Z « 4J o dH si <; w H 4-) a « o Pi ^ 1 o SS tn O 02 a o ^. i S is to i S ^S H §3 gflS ERITONEi Intestine Mesente Omentu Rectum Retrone EMALE G Broad li Ovarv. . Pelvic o Uterus. Vulva. . U2 a, c- c: 1 a. a c c C rHER Or Abdonie Antrum Arm < >-> 11 mm Ah f^ PC O 1 527 APPENDIX F (PART II) ^ 1 ^•'u oe<5 <» -0000 WW •i>©so •'»o ■*•<=> S -"S © eo so ' o o< o GO CO ■ CO o CO ' >c o ' »o ■ d ya»ci-i CO osi-ioeoco rHOco »c I-H O ^< C J2 r-l Ot • ®» . Oi Vi i-< i-li-l • t- S» 1-1 • rH (N a ' oS'''®*'^ o<«ceooi— '■^ oeooco oo cosiio O »C O l-H Tj4 < i.'O '-' '"' rH i-H z S^ o fL,^ H ->1 Pi m J3rHeO(»< • •S .t-lr-HrH- o Pi ^ £ • 00 »« 1-1 --1 •* • ©» • ■ 05 • • rl -00 • 1-1 ■»«.-( rH a • 3 . rH -I-H • -Jl 1-1 . ^ V .GOCOl> -OO • • •«5 -SO • -O • • -O • ■* o • S.-S "cocoo 'joo ■ ■ "o 'eo ■ 'i-! ■ ■ 'o 00 d • oa'-c©»i-io©»iocooor-ii-c© 'S o 1 3 n S < ^(XLOoeo^oooicO'^oosi-teoooi-ioJsiso •oo-*©! • 1-H i-H a c Hi ■J X c is 0. 2: c 1 bfi ^ fH « e n^ r!" r?' "bb si ii a; c: c c/: c ■0 ■§ >> H O 1 528 APPENDIX F (PART II) o-o *:_2 05i-iO<»t-;i-^'J'. u a tp ^ i-H .-H o< JD s(5-^f-lt^>O'--i t- o< <« 4JI' ?Cl»COO500 00O S.ti OJ CO 06 06 GO c^ •*' (jar-li-( (5*0O0O©» 0-0 o CO CO ■*! pi ,-1 1-1 BO i-i 0 t~ "O CO lO o^ o< 1> O i> 00 »< o o o i> d 1-! o r-H i-l CO -# CO 00 i-l ,-< ®» CO CO d 00 e< s» 00 ■<* ■* »q d d i-< d d 131 00 S« 0< i-i c o g ej « 0) 6^ g *" —I ^ =!_« w g E c D .S equ2tiHfe«u30 1) o c3 be 03 C S .0 O Q < 5 tH r^ ^ 4) -- > S P H o Q < in iz; S =s I— I • ©( -2 o» -* ®« o CO crt o CO 0< i-H (3< ■^ £ l-H O S-- »> CO u a «5 CO o • • GO O CO CO CO d ■ so "O ■ GO d OO' GO 00 O so GO • O* I-H l-H l-H CO »C O i-i GO si •o t~ Oi t- e* i> "* (6 <6 <6 ci ©» }> GO I- c: J> d d i-H d d d co:i O x t^ .o ^-iJ eS oi nrtmpnt nf .^t T.niiis Mn 1891-1895 2,429,981 1,258 51.8 1896 522,209 268 51.3 1897 534,977 266 49.7 1898 548,057 304 55.5 1899 561,4.56 297 52.9 1900 575,238 345 60.0 54.0 1896-1900 2,741,937 1,480 570 APPENDIX F {PART II) Table 174 Mortality from Cancer in St. Louis, Mo., Males 1887-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1887 212,691 71 33.4 1901 293,912 151 51.4 1888 217,400 74 34.0 1902 299,635 150 50.1 1889 222,744 77 34.6 1903 305,362 182 59.6 1890 228,099 127 55.7 1904 311,155 161 51.7 1905 316,955 162 51.1 1887-1890 880,934 349 39.6 1901-1905 1,527,019 806 52.8 1891 233,491 115 49.3 1892 239,010 106 44.3 1906 322,762 218 66.0 1893 244,660 86 35.2 1907 328,575 202 61.5 1894 250,443 100 39.9 1908 334,395 229 68.5 1895 256,332 111 43.3 1909 340,222 246 72.3 1910 346,057 248 71.7 1891-1895 1,223,936 518 42.3 1906-1910 1,672,011 1,138 68.1 1896 262,410 116 44.2 1897 268,612 108 40.2 1911 351,897 213 60.5 1898 274,960 137 49.8 1912 357,744 260 72.7 1899 281,458 127 45.1 1913 363,588 325 89.4 1900 288,194 117 40.6 Source: Annual and Monthly Reports 1896-1900 1,375,634 605 44.0 of the Health Department of St. Louis, Mo. Table 175 Mortality from Cancer in St, Louis Mo., Females 1887-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1887 206,818 93 45.0 1901 292,505 194 66.3 1888 211,990 96 45.3 1902 297,961 206 69.1 1889 217,810 112 51.4 1903 303,413 210 69.2 1890 223,671 136 60.8 1904 308,799 213 69.0 1905 314,178 257 81.8 1887-1890 860,289 437 50.8 1901-1905 1,516,856 1,080 71.2 1891 229,325 160 69.8 1892 235,122 142 60.4 1906 319,550 230 72.0 1893 241,065 157 65.1 1907 324,916 277 85.3 1894 247,158 124 50.2 1908 330,275 319 96.6 1895 253,375 157 62.0 1909 335,627 323 96.2 1910 340,972 320 93.8 1891-1895 1,206,045 740 61.4 1906-1910 1,651,340 1,469 89.0 1896 259,799 152 58.5 1897 266,365 158 59.3 1911 346,311 313 90.4 1898 273,097 167 61.2 1912 351,643 344 97.8 1899 279,998 170 60.7 1913 356,978 357 100.0 1900 287,044 228 79.4 Source: Annual and Monthly Reports 1896-1900 1,366,303 875 64.0 of the Health Department of St. Louis, Mo. 571 APPENDIX F {PART II) Table 176 Mortality from Cancer in St. Paul, Minn. 1885-1913 Year Deaths Rate per (Ending Population from 100,000 October 31) Cancer Population 1885 74,305 36 48.4 1886 83,497 29 34.7 (Calendar) 1887 93,826 23 24.5 1888 1889 118,474 39 32.9 1890 133,156 45 33.8 1886-1890 428,953 136 31.7 1891 134,583 62 46.1 1892 136,010 62 45.6 1893 137,437 58 42.2 1894 138,864 51 36.7 1895 140,292 67 47.8 1891-1895 687,186 300- 43.7 1896 144,846 67 46.3 1897 149,400 52 34.8 1898 153,955 74 48.1 1899 158,510 66 41.6 1900 163,065 92 56.4 1896-1900 769,776 351 45.^ 1901 169,856 60 35.3 1902 176,647 83 47.0 1903 183,439 107 58.3 1904 190,231 115 60.5 1905 197,023 115 58.4 1901-1905 917,196 480 52.3 1906 200,567 121 60.3 1907 204,111 135 66.1 1908 207,655 159 76.6 1909 211,199 143 67.7 1910 214,744 180 83.8 1906-1910 1,038,276 738 71.1 1911 218,288 160 73.3 1912 221,832 160 72.1 1913 225,376 187 83.0 Source: Annual Reports of the Board of Health of the City of St. Paul, Minn. 672 APPENDIX F (PART II) Table 177 Mortality from Cancer in District of Columbia 1879-1914 Year Deaths Rate per Deaths Rate per (Ending Population from 100,000 Year Population from 100,000 June 30) Cancer PopulatioQ Cancer Population 1879 171,919 94 54.7 1901 283,953 194 68.3 1880 177,624 78 43.9 1902 289,188 218 75.4 1903 294,423 220 74.7 1881 182,900 87 47.6 1904 299,658 228 76.1 1882 188,176 80 42.5 1905 304,893 231 75.8 1883 193,453 77 39.8 1884 198,730 88 44.3 1901-1905 1,472,115 1,091 74.1 1885 204,007 119 58.3 1906 310,128 253 81.6 1881-1885 967,266 451 46.6 1907 315,363 280 88.8 1908 320,598 275 85.8 1886 209,284 101 48.3 1909 325,833 278 85.3 1887 214,561 112 52.2 1910 331,069 293 88.5 1888 219,838 103 46.9 1889 225,115 118 52.4 1906-1910 1,602,991 1,379 86.0 1890 230,392 121 52.5 1911 336,305 286 85.0 1886-1890 1,099,190 555 50.5 1912 341,541 323 94.6 1913 346,777 351 101.2 1891 235,224 131 55.7 1914 352,015 344 97.7 1892 240,056 111 46.2 1893 244,888 152 62.1 Source: Annual Reports of the Health 1894 249,720 130 52.1 Officer of the District of Columbia 1895 254,553 140 55.0 54.2 Note: 1902-1914, Calendar Ye ars. 1891-1895 1,224,441 664 1896 259,386 155 59.8 1897 264,219 144 54.5 1898 269,052 160 59.5 1899 273,885 177 64.6 1900 278,718 204 73.2 62.4 1896-1900 1,345,260 840 573 APPENDIX F {PART II) Table 178 Mortality from Cancer in District of Columbia, Males 1879-1913 Year Deaths Rate per Deaths Rate per (En.Iin? Population from 100,000 Year Population from 100,000 June3U) Cancer Population Cancer Population 1879 80,842 18 22.3 1901 134,608 65 48.3 1880 83,578 28 33.5 1902 137,212 77 56.1 1903 139,816 70 50.1 1882 88,778 29 32.7 1904 142,420 79 55.5 1883 91,378 24 26.3 1905 145,025 82 56.5 1884 93,978 26 27.7 1885 96,579 35 36.2 30.8 1901-1905 1906 699,081 147,630 373 105 53.4 1882-1885 370,713 114 71.1 1907 150,235 94 62.6 1886 99,180 30 30.2 1908 152,840 100 65.4 1887 101,781 33 32.4 1909 155,445 111 71.4 1888 104,382 32 30.7 1910 158,050 116 73.4 1889 106,983 28 26.2 1890 109,584 32 155 29.2 29.7 1906-1910 1911 764,200 160,655 526 108 68.8 1886-1890 521,910 67.2 1912 163,260 127 77.8 1891 111,826 41 36.7 1913 165,865 137 82.6 1892 114,068 41 35.9 1893 116,310 50 43.0 Source: Annual Reports of the Health 1894 118,552 59 49.8 Officer of the District of Columbia. 1895 120,794 45 37.3 40.6 Note: 1902-1913, Calendar Y ears. 1891-1895 581,550 236 1896 123,036 41 33.3 1897 125,278 51 40.7 1898 127,520 51 40.0 1899 129,762 58 44.7 1900 132,004 70 53.0 42.5 1896-1900 637,600 271 574 APPENDIX F (PART 11) Table 179 Mortality from Cancer in District of Columbia, Females 1879-1913 Year Deaths Rate per Deaths Rate per (Ending Population from 100,000 Year Population from 100,000 June 30) Cancer Population Cancer Population 1879 91,077 76 83.4 1901 149,345 129 86.4 1880 94,046 50 53.2 1902 151,976 141 92.8 1903 154,607 150 97.0 1882 99,398 51 51.3 1904 157,238 149 94.8 1883 102,075 53 51.9 1905 159,868 149 93.2 1884 104,752 62 59.2 1885 107,428 84 78.2 60.4 1901-1905 1906 773,034 162,498 718 148 92.9 1882-1885 413,653 250 91.1 1907 165,128 186 112.6 1886 110,104 71 64.5 1908 167,758 175 104.3 1887 112,780 79 70.0 1909 170,388 167 98.0 1888 115,456 71 61.5 1910 173,019 177 102.3 1889 118,132 90 76.2 1890 120,808 89 73.7 69.3 1906-1910 1911 838,791 175,650 853 178 101.7 1886-1890 577,280 400 101.3 1912 178,281 196 109.9 1891 123,398 90 72.9 1913 180,912 214 118.3 1892 125,988 70 55.6 1893 128,578 102 79.3 Source: Annual Reports of tl e Health 1894 131,168 71 54.1 Oflacer of the District of Columbia. 1895 133,759 95 71.0 66.6 Note: 1902-1913, Calendar Y ears. 1891-1895 642,891 428 1896 136,350 114 83.6 1897 138,941 93 66.9 1898 141,532 109 77.0 1899 144,123 119 82.6 1900 146,714 134 91.3 80.4 1896-1900 707,660 569 38 575 APPENDIX F {PART II) Table 180 Mortality from Cancer in District of Columbia, White 1882-1914 Year Deaths Rate per Deaths Rate per (Ending Population from 100,000 Year Population from 100,000 June 30) Cancer Population Cancer Population 1882 125,343 55 43.9 1901 195,991 137 69.9 1883 129,012 51 39.5 1902 200,450 173 86.3 1884 132,681 64 48.2 1903 204,909 162 79.1 1885 136,350 86 63.1 1904 209,368 173 82.6 1905 213,828 179 83.7 1882-1885 523,386 256 48.9 1901-1905 1,024,546 824 80.4 1886 140,019 78 55.7 1887 143,688 78 54.3 1906 218,288 188 86.1 1888 147,357 77 52.3 1907 222,748 219 98.3 1889 151,026 98 64.9 1908 227,208 206 90.7 1890 154,695 92 59.5 1909 231,668 209 90.2 1910 236,128 239 iOl.2 1886-1890 736,785 423 57.4 1906-1910 1,136,040 1,061 93.4 1891 158,378 90 56.8 1892 162,061 87 53.7 1911 240,587 215 89.4 1893 165,744 116 70.0 1912 245,046 245 100.0 1894 169,428 98 57.8 1913 249,508 278 111.4 1895 173,112 111 64.1 60.6 1914 Source: 253,970 259 Annual Reports of th 102.0 1891-1895 828,723 502 e Health Officer of the District of Columbia 1896 176,796 115 65.0 Note: 1902-1914, Calendar Years. 1897 180,480 98 54.3 1898 184,164 118 64.1 ' 1899 187,848 126 67.1 1900 191,532 145 75.7 65.4 1896-1900 920,820 602 576 APPENDIX F {PART II) Table 181 Mortality from Cancer in District of Columbia, Colored 1882-1914 Year Deaths Rate per Deaths Rate per (Ending Population from 100,000 Year Population from 100,000 June 30) Cancer Population Cancer Population 1882 62,833 25 39.8 1901 87,962 57 64.8 1883 64,441 26 40.3 1902 88,738 45 50.7 1884 66,049 24 36.3 1903 89,514 58 64.8 1885 67,657 33 48.8 1904 90,290 55 60.9 1905 91,065 52 67.1 1882-1885 260,980 108 41.4 1901-1905 447,569 267 59.7 1886 69,265 23 33.2 1887 70,873 34 48.0 1906 91,840 65 70.8 1888 72,481 26 35.9 1907 92,615 61 65.9 1889 74,089 20 27.0 1908 93,390 69 73.9 1890 75,697 29 38.3 1909 94,165 69 73.3 1910 94,941 54 56.9 1886-1890 362,405 132 36.4 1906-1910 466,951 318 68.1 1891 76,846 41 53.4 1892 77,995 24 30.8 1911 95,718 71 74.2 1893 79,144 36 45.5 1912 96,494 78 80.8 1894 80,292 32 39.9 1913 97,269 73 75.0 1895 81,441 29 35.6 40.9 1914 Source: 98,045 85 Annual Reports of the 86.7 1891-1895 395,718 162 Health Officer of the District of Columbia 1896 82,590 40 48.4 Note: 1902-1914, Calendar Years. 1897 83,739 46 54.9 1898 84,888 42 49.5 1899 86,037 61 59.3 1900 87,186 59 67.7 56.1 1896-1900 424,440 238 577 APPENDIX F {PART II) Table 182 Mortality from Cancer, by Organs and Parts, in the District of Columbia according to Age, White Males, 1901-1910 Bdccal Cavity Stomach AND Liver Deaths from Cancer Rate per 100,000 Population Deaths from Cancer Rate per 100,000 Population JnderlO 0.6 1 10-19 1 0.6 20-29 3 1.4 30-39 2 1.1 18 9.7 40-49 4 3.0 38 28.3 50-59 17 19.0 80 89.5 60-69 13 23.0 125 221.0 70 and over 12 37.0 87 268.3 All ages 49 4.6 352 33.4 40 and over 46 14.7 330 105.5 Peritoneum Intestines and Rectum Skin Under 10 1 0.6 1.8 10-19 3 20-29 3 1.4 6.5 1 0.5 30-39 12 40-49 15 11.2 3 2.2 50-59 21 23.5 11 12.3 60-69 32 56.6 15 26.5 70 and over 21 64.8 18 55.5 All ages 108 10.2 48 4.6 89 28.5 r Specified NS 47 All Orga 15.0 Other or No Orga vs AND Parts Under 10 2 1.1 1.2 3 7 1.7 10-19 :. 2 4.2 20-29 5 2.4 12 5.8 30-39 11 5.9 17.9 43 84 23.2 40-49 24 62.5 50-59 34 38.1 163 182.4 60-69 49 86.6 234 413.7 70 and over 60 185.0 17.7 198 744 610.6 All ages 187 70.6 40 and over 167 53.4 679 217.1 578 APPENDIX F {PART II) Table 183 Mortality from Cancer, by Organs and Parts, in the District of Columbia according to Age, White Females, 1901-1910 Under 10. 10-19.... 20-29.... 30-39.... 40-49.... 50-59.... 60-69.... 70 and over. All ages. . . . 40 and over. Under 10. 10-19.... 20-29.... 30-39. . . . 40-49.... 50-59. . . . 60-69. . . . 70 and over. Aliases 331 40 and over Buccal Cavity Stomach and Liveb Peritoneum Intestines and Rectum Deaths from Cancer Rate per 100,000 Population Deaths from Cancer Rate per 100,000 Population Deaths from Cancer Rate per 100,000 Population i 0.4 2 0.9 i 0.4 17 8.7 11 5.6 2 1.4 44 31.3 24 17.1 83 87.6 45 47.5 6 9.5 96 151.6 33 52.1 3 8.6 59 168.5 23 65.7 12 1.1 301 27.1 137 12.4 11 3.3 282 84.5 125 37.5 Fem.ale Genebative Organs Breast & KLN Deaths from Cancer Rate per 100,000 Population Deaths from Cancer Rate per 100,000 Population Deaths from Cancer Rate per 100,000 Population 1 0.6 i 0.6 49 24.9 16 8.i 1 0.5 88 62.6 48 34.1 2 1.4 101 106.6 63 66.5 3 3.2 59 93.2 55 86.9 6 9.5 33 94.2 43 122.8 12 34.3 331 29.9 225 20.3 25 2.3 281 84.2 209 62.6 23 6.9 Other or Not Specified Organs Deaths Rate per from 100,000 Cancer Population Under 10 1 0.6 10-19 1 0.6 20-29 3 1.3 30-39 16 8.1 40-49 20 14.2 50-59 34 35.9 60-69 34 53.7 70 and over 22 62.8 Allages 131 11.8 40 and over 110 33.0 All Organs and Parts Deaths Rate per from Cancer 1 3 7 110 228 329 289 195 1,162 1,041 100,000 Population 0.6 1.7 3.1 56.0 162.2 347.3 456.4 556.9 104.8 312.0 579 APPENDIX F {PART II) Table 184 Mortality from Cancer, by Organs and Parts, in the District of Columbia according to Age, Colored Males, 1901-1910 Under 10.... 10-19 20-29 30-39 40-49 50-59 60-69 70 and over . All ages . . . . . 40 and over. . Under 10 10-19 20-29 30-39 40-49 50-59 60-69 70 and over . All ages 40 and over. . 3.2 0.2 1.0 Buccal Cavity Stomach AND Liver Deaths from Cancer Rate per 100,000 Population Deaths from Cancer Rate per 100,000 Population 3 3.2 1 1.4 11 15.2 2 4.1 15 30.5 2 6.5 26 • 84.4 3 22.7 22 166.4 5 76.2 10 152.3 13 3.2 87 21.3 12 12.0 73 73.1 Breast Skin Deaths from Cancer Rate per 100,000 Population Deaths from Cancer Rate per 100,000 Population 2.2 2.8 2.0 6.5 15.1 5.0 All Organs Deaths Rate per from 100,000 Cancer Population Under 10 10-19 20-29 .... 9 9.7 30-39 .... 19 26.3 40-49 .... 24 48.7 50-59 . . . . 43 139.6 60-69 . . . . 41 310.1 70 and over .... . . . . 22 335.1 All ages 158 38.6 40 and over .... 130 130.2 Peritoneum Intestines and Rectum Deaths Rate per from 100,000 Cancer Population 1 2.0 5 16.2 5 37.8 3 45.7 16 3.9 14 14.0 Other Organs Deaths Rate per from 100,000 Cancer Population 25 2.2 6.9 10.2 22.7 68.1 60.9 7.8 25.0 580 APPENDIX F {PART II) Table 185 Mortality from Cancer, by Organs and Parts, in the District of Columbia according to Age, Colored Females, 1901-1910 1 Pehitoneum BuccAii Cavity Stomach and Liver | Intestines and Rectom Deaths Rate per Deaths Rate per Deaths Rate per from 100,000 from 100,000 from 100,000 Cancer Population Cancer Population Cancer Population Under 10 i 0.8 4 3.i i 2 10-19 1.1 20-29 1.5 30-39 2 2.3 10 11.3 5 5.6 40-49 2 3.4 16 27.4 7 12.0 50-59 2 5.9 31 91.0 12 35.2 60-69 3 17.6 14 82.0 3 17.6 70 and over. 3 30.1 16 160.6 4 40.2 All ages 13 2.6 91 18.1 34 6.8 40 and over . . 10 8.4 Female 77 64.5 26 21.8 Generative Ohgans Breast Skin Deaths Rata per Deaths Rate per Deaths Rate per from 100,000 from 100,000 from 100,000 Cancer Population Cancer Population Cancer Population Under 10 1 1.3 10-19 20-29 6 4.6 3 2.3 30-39 34 38.4 9 10.2 i i.i 40-49 65 111.4 21 36.0 50-59 42 123.3 15 44.1 60-69 25 146.5 15 87.9 70 and over 15 150.6 10 100.4 All ages 188 37.4 73 14.5 1 0.2 40 and over. 147 123.1 Othe 61 B Organs 51.1 Ai ji Organs Deaths Rate per Death 3 Rate per from 100,000 from 100,000 Cancer Population Cance r Population Under 1 10-19.. 1 1.3 2 1 2.7 1.1 ' 20-29.. 1 0.8 17 13.1 30-39.. 3 3.4 64 72.3 40-49. . 10 17.1 121 207.3 50-59.. 10 29.4 112 328.9 60-69.. 6 35.1 66 386.6 70 and over. . . 4 40.2 52 522.1 All ages 35 7.0 435 86.5 40 and over. . . . 30 25.1 351 293.9 Note: Tables 182-185 are from the same source as Tables 177-181, but data are for Calendar Years. 581 APPE>"DIX G Cancer Mortality Statistics of Foreign Countries Table Country Period Title Page 1 CmLizED World 1908-1912 Persons 593 2 Peixctpal Countries 1901-1905—1906-1910 Persons 593 3 Selected Coxtn-tries 1908-1912 Crude and Standard- ized Rates 593 i Europe By Countries 594 5 Countries of Europe 1896-1910 Comparative State- ment 595 6 England and Wales 1881-1913 Persons 596 7 " " 1881-1913 Males 596 8 " " 1881-1913 Females 597 9 " " 1901-1910 By Age and Sex 597 10 " " 1908-1912 By Organs and Parts. according to Sex 598 11 " " 1897-1900— 1901-1910 Bv Organs and Parts, Males 599 12 " " 1897-1900—1901-1910 By Organs and Parts, Females 600 13 " " 1901-1910 Relative Mortality, by Organs and Parts, ac- cording to Sex 601 14 " " 1903-1912 FemaleBreast 601 15 " " 1911-1912 Urban and Rural, by Organs and Parts, ac- cording to Sex 602 15a " " 1911-1913 Cancer of the Ovarj', by Age and Conjugal Condition 603 15b " " 1911-1913 Cancer of the Uterus, by Age and Conjugal Condition 603 15c " " 1911-1913 Cancer of the Breast, by Age and Conjugal Condition 60-1 15d London 1649-1758 Cancer, Fistula and Gangrene 604 16 " 1881-1913 Persons 605 17 " 1881-1913 Males 605 18 " 1881-1913 Females 606 19 SheflBeld 1887-1913 Persons 607 582 APPENDIX G Table Country Period Title Page England and Wales {coiilinued) 20 Sheffield 1887-1913 Males 607 21 " 1887-1913 Females 608 22 Liverpool 1889-1913 Persons 608 23 " 1889-1913 Males 609 24 " 1889-1913 Females 609 25 Birmingham 1891-1912 Persons 610 26 " 1904-1912 By Sex 610 27 Leeds 1893-1913 Persons 611 28 Bristol 1894-1913 Persons 611 29 Manchester 1891-1912 Persons 612 30 " 1891-1912 Males 612 31 " 1891-1912 Females 613 32 Scotland 1881-1912 Persons 613 33 " 1906-1912 By Sex 614 34 " 1906-1910 By Organs and Parts, according to Sex. ..... 614 35 " 1906-1910 Relative Mortality, by Organs and Parts, ac- cording to Sex 615 36 Aberdeen 1899-1913 Persons 615 37 Edinburgh 1898-1913 Persons 616 38 " 1898-1913 Males 616 39 " 1898-1913 Females 617 40 Glasgow 1881-1913 Persons 617 41 Ireland 1881-1912 Persons 618 42 " 1893-1912 Males 619 43 " 1893-1912 Females 619 44 " 1901-1910 By Provinces and Counties 620 45 " 1901-1910 By Organs and Parts, according to Sex 621 46 " 1901-1910 By Age and Sex 622 47 " , 1901 By Organs and Parts and Duration of Ill- ness, Males 623 48 " 1901 By Organs and Parts and Duration of Ill- ness, Females 624 49 Dubhn 1901-1912 Persons 625 50 Belfast 1901-1912 Persons 625 51 Isle of Man 1902-1913 Persons 626 52 " 1902-1913 Males 626 53 " 1902-1913 Females 627 54 Guernsey, Channel Islands 1900-1913 Persons 627 55 Gibraltar 1900-1913 Persons 628 56 Malta and Gozo 1896-1912 Persons 628 57 " " 1911-1913 By Organs and Parts, according to Sex 629 58 Norway 1881-1912 Persons 629 59 " 1896-1912 Males 630 583 APPENDIX G Table Country Period Title Page 60 Norway 1896-1912 Females 630 61 " 1896-1910 By Organs and Parts, according to Sex 631 62 " 1896-1910 Relative Mortality, by Organs and Parts, ac- cording to Sex 631 63 " 1896-1910 By Age and Sex 631 64 " 1896-1910 By Organs and Parts, according to Age, Males 632 65 " 1896-1910 By Organs and Parts, according to Age, Fe- males 632 66 " 1896-1901 Urban and Rural, by Organs and Parts, ac- cording to Sex 633 67 " 1896-1907 By Organs and Parts, and Geographical Di- visions 633 68 Kristiania 1896-1912 Persons 633 69 Bergen 1896-1912. .......... Persons 634 70 Hammerfest 1896-1911 Persons 634 71 Sweden 1901-1912 By Cities 634 72 " 1911 Urban and Rural, by Sex 634 73 " 1905 By Provinces and Sex 635 74 " 1905 Urban and Rural, by Organs and Parts, Males 636 75 " 1905 Urban and Rural, by Organs and Parts, Females 636 76 Stockholm 1908-1913 Persons 637 77 Goteborg 1908-1913 Persons 637 78 Denmark 1881-1912 By Cities 637 79 " 1894-1912 By Cities, Males ... . 638 80 " 1894-1912 By Cities, Females. . . 638 81 " 1908-1912 Cities, by Organs and Parts, according to Sex 638 82 Copenhagen 1894-1912 Persons 639 83 " 1894-1912 By Sex 639 84 Iceland 1908 By Organs and Parts, according to Sex 640 85 Finland 1909 By Organs and Parts, according to Sex 640 86 " 1890-1907 By Organs and Parts 641 87 " and Sweden 1890-1907 By Organs and Parts 641 87a " 1910 By Cities 641 88 German Empire 1891-1912 Persons 642 89 " " 1905-1912 BySex 642 90 Bavaria 1886-1912 Persons 643 91 " 1886-1912 Males 643 92 " 1886-1912 Females 644 584 APPENDIX G Table Country Period Title Page German Empire {contiiiucJ) 93 Bavaria 1905-1907 By Geographical Di- visions, Males 644 94 " 1905-1907 By Geographical Di- visions, Females 645 95 " 1905-1910 By Organs and Parts, according to Sex 645 95a " 1901-1912 By Age 646 96 Prussia 1881-1912 Persons 646 97 " 1898-1912 Males 647 98 " 1898-1912 Females 647 98a " 1903-1913 By Age and Sex 647 99 Wiirttemberg 1904-1912 By Sex 648 100 Baden 1881-1912 Persons 648 101 " 1905-1912 By Sex 649 102 Saxony 1904-1912 By Sex 649 103 Alsace-Lorraine 1905-1912 Persons 650 103a Grand-Duchy of Hesse. . . .1901-1912 By Religion, accord- ing to Age and Sex . . 650 104 Hehgoland 1840-1903 Persons 650 105 " 1840-1903 By Organs and Parts, according to Sex 651 106 Hamburg 1900-1912 By Sex 651 107 Bremen 1896-1913 Persons 652 108 " 1896-1911 BySex 652 109 Berlin 1881-1912 Persons 653 110 " 1881-1912 Males 653 111 " 1881-1912 Females 654 112 Frankfurt a/M 1891-1913 Persons 654 113 " 1892-1913 Males 655 114 " 1892-1913 Females 655 115 " 1906-1912 By Organs and Parts, according to Sex 656 116 Cologne 1891-1912 Persons 656 117 Essen a/R 1906-1912 By Sex 657 118 Munich 1896-1912 Persons 657 119 " 1896-1911 By Sex 658 120 " 1907-1909 By Religious Confes- sion, according to Organs and Parts, Females 658 121 Dresden 1886-1912 Persons 659 122 Leipzig 1881-1912 Persons 659 123 Konigsberg 1881-1912 Persons 660 124 Nuremberg 1881-1912 Persons 660 125 Holland 1881-1913 Persons 661 126 " 1901-1913 BySex 661 127 " 1906-1912 By Organs and Parts, according to Sex 662 128 Amsterdam 1881-1913 Persons 662 129 " 1901-1912 BySex 663 585 APPENDIX G Table Country Period Title Page Holland (continued) 130 Amsterdam 1862-1902 By Organs and Parts, Males 663 131 " 1862-1902 By Organs and Parts, Females 664 132 " 1897-1902 By Organs and Parts, according to Age, Males 664 133 " 1897-1902 By Organs and Parts, according to Age, Fe- males 665 134 The Hague 1901-1913 Persons 665 135 " 1901-1912 By Sex 666 136 Rotterdam 1901-1913 Persons 666 137 " 1901-1912 By Sex 667 138 Belgium 1903-1912 Persons 667 139 " 1903-1912 Males 667 140 " 1903-1912 Females 668 141 Liege 1903-1912 Persons 668 142 " 1905-1912 BySex 668 143 Antwerp 1896-1912 Persons 669 144 Brussels 1901-1912 Persons 669 145 France 1892-1911 Persons 670 146 " 1906-1910 By Cities, according to Size 670 147 Paris 1881-1913 Persons 671 148 " 1893-1913 Males 671 149 " 1893-1913 Females 672 150 Lyons 1910-1912 Persons 672 151 Bordeaux 1909-1912 Persons 672 152 Nice 1909-1912 Persons 672 153 Lille 1891-1912 Persons 673 154 Nancy 1901-1912 Persons 673 155 Le Havre 1901-1912 Persons 673 156 Switzerland 1881-1912 Persons 674 157 " 1881-1885— 1901-1912 Males 674 158 " 1881-1885— 1901-1912 Females 675 159 " 1901-1910 By Organs and Parts, according to Sex .... 675 160 " 1901-1910 Relative Mortality, by Organs and Parts, according to Sex 676 161 " ,1906-1910 By Organs and Parts, according to Sex 676 162 " 1906-1910 By Cantons and Race 677 163 " 1901-1910 ByAgeandSex 677 164 Bern 1901-1912 Persons 678 165 Basel 1901-1912 Persons 678 166 Geneva 1901-1912 Persons 678 167 Zurich 1901-1912 Persons 678 586 APPENDIX G Table Country Period Title Page 168 Austria 1895-1912 Persons 679 169 " 1901-1912 BySex 679 170 " 1907-1911 By Provinces and Race 680 171 " 1909-1910 By Principal Cities... 681 172 Vienna 1900-1912 Persons 681 173 " 1900-1912 By Sex 682 174 " 1898-1912 Jewish Population .. . 682 175 " 1898-1912 Jewish Population, by Sex 683 176 Hungary 1897-1912 Persons 683 177 " 1897-1908 By Sex 684 178 " 1901-1904 By Organs and Parts, according to Sex 685 179 " 1904 Percentage of Distri- bution, by Organs and Parts, according to Sex 685 180 " 1901-1904 By Race 686 181 Budapest 1881-1912 Persons 686 182 " 1881-1912 Males 687 183 " 1881-1912 Females 687 184 " 1902-1906 By Religious Confes- sion 688 185 Italy 1887-1912 Persons 688 186 " 1896-1912 Males 689 187 " 1896-1912 Females 689 '88 " 1906-1910 By Provinces 690 189 " 1891-1910 By Organs and Parts. 690 190 Rome 1898-1912 Persons 691 191 Naples 1898-1912 Persons 691 192 Genoa 1898-1912 Persons 691 193 Turin 1898-1912 Persons 692 194 Milan 1898-1912 Persons 692 195 Florence 1898-1912 Persons 692 196 Palermo 1898-1912 Persons 693 197 Spain 1900-1912 Persons 693 198 " 1900 Urban and Rural, by Organs and Parts .... 693 198a " 1901-1905 By Organs and Parts, according to Sex .... 694 199 Madrid 1901-1910 Persons 694 200 Portugal 1902-1910 Persons 694 201 " 1902-1910 By Sex 695 202 " 1906-1910 By Provinces 695 203 " 1904 By Organs and Parts, according to Sex (Can- cer Census) 696 204 Porto 1893-1910 Persons 696 205 Lisbon 1902-1910 Persons 697 587 APPENDIX G Table Country Period Title Page Russia 206 Moscow 1892-1910 By Sex 697 207 " 1910-1912 Persons 697 208 Petrograd 1911-1912 Persons 697 208a Warsaw 1881-1912 Persons 698 209 Serbia 1892-1912 Persons 698 210 " 1907-1912 Cities 699 211 Greece 1900-1908 , . . . Twelve Cities 699 212. " 1905-1908 Twelve Cities, by Or- gans and Parts, ac- cording to Sex 699 213 Athens 1900-1908 By Sex 700 214 Roumania 1901-1912 By Cities 701 Turkey 215 Constantinople 1908-1912 Persons 701 216 " 1908-1912 By Religion 701 217 Africa By Countries 702 218 Algeria 1904-1912 European Population 702 219 Mauritius 1898-1912 Persons 703 220 " 1898-1908 Public Hospital Cases 703 221 Union of South Africa 1912 By Organs and Parts, according to Sex, White 703 222 " " " 1912 By Provinces, White 704 223 Cape Colony 1900-1908 Tw«nty-five Cities and Towns 704 224 Johannesburg 1909-1911 By Race 704 225 Natal 1902-1912 European Population. 705 226 " 1903-1912 East Indians 705 227 Sierra Leone 1870-1909 Cases in the Colonial Hospital 705 228 " " 1900-1909 Cases in the Colonial Hospital, by Organs and Parts 706 229 Freetown 1910-1911 Persons 706 Portuguese Colonies 230 Cape Verde Islands 1892-1904 Cases of Tumor, Hos- pital da Praia, by Race 706 231 " " " 1892-1904 Cases of Cancer, Hos- pital da Praia, by Or- gans and Parts, accord- ing to Race and Sex. . . 707 232 Asia By Countries 708 India 233 Calcutta 1881-1913 Persons 708 234 Province of Bengal 1911-1912 Morbidity and Mor- tality in Hospitals . . . 709 235 Ceylon 1881-1913 Persons 709 236 " 1911-1913 By Organs and Parts 710 237 " 1911-1913 By Organs and Parts, according to Race. . . 710 238 " 1911-1913 By Administrative Di- visions 711 588 APPENDIX G Table Country Period Title Page 239 Straits Settlements 1904-1912 Cases of Cancer in the Hospitals 711 240 Singapore 1904-1913 Persons 712 241 Province of Penang 1909-1913 Persons 712 242 Singapore 1907-1912 Cases in Tan Toch Seng's Hospital, by Organs and Parts. . . . 712 243 Seychelles. 1900-1902—1907-1911 Victoria Hospital Ex- perience 713 244 " 1907-1911 Victoria Hospital Ex- perience, by Organs and Parts 713 245 Dutch East Indies 1911-1912 Europeans 713 China 246 Hongkong 1901-1912 By Race 714 247 " 1895-1904 By Organs and Parts, Chinese Population . . 714 248 Shanghai 1898-1914 Resident Foreign Pop- ulation 715 248a Fukien 1911-1914 Yunghun Hospital Ex- perience, by Organs and Parts 715 249 Japan 1899-1911 Persons 715 250 " 1899-1910 By Sex 716 251 " 1909-1910 By Organs and Parts, according to Sex 716 252 " 1908-1910 By Age and Sex 717 253 Tokyo 1904-1910 Persons 717 254 " 1904-1910 By Sex 718 255 Osaka 1906-1910 By Sex 718 256 Kyoto 1906-1910 By Sex 719 Philippine Islands 257 Manila 1903-1913 Persons 719 258 " 1908-1913 By Organs and Parts, according to Race . . . 719 259 Australasia By Countries 720 260 Commonwealth of AustraHa 1881-1913 Persons 720 261 " " .... 1908-1912 By Organs and Parts, according to Sex 721 262 " " ....1908-1912.. By Age and Sex 722 263 New South Wales 1881-1913 Persons 723 264 " " " 1881-1913 Males 724 265 " " " 1881-1913 Females 724 266 " " " 1881-1911 By Age and Sex 725 267 Sydney 1891-1913 Persons 726 268 " 1891-1913 Males 726 269 " 1891-1913 Females 727 270 Victoria 1881-1913 Persons 727 271 " 1881-1913 Males 728 272 " 1881-1913 Females 728 273 " 1880-82, 1890-92, 1900-02, 1909-11 By Age and Sex 729 589 APPENDIX G Table Country Period Title Page Commonwealth of Australia {continued) 274 South Austraha 1881-1913 Persons 730 275 " " 1882-1913 Males 730 276 " " 1882-1913 Females 731 277 Queensland 1881-1913 Persons 731 278 " 1893-1913 Males 732 279 " 1893-1913 Females 732 280 Tasmania 1884-1913 Persons 733 281 " 1892-1913 Males 733 282 " 1892-1913 Females 734 283 Western Australia 1881-1913 Persons 734 284 " " 1897-1913 Males 735 285 " " 1897-1913 Females 735 286 Northern Territory 1911-1913 Persons 735 287 New Zealand 1881-1913 Persons 736 288 " " 1889-1913 Males 736 289 " " 1889-1913 Females 737 290 Fiji 1898-1911 Colonial Hospital Ex- perience 737 291 " 1905-1911 Colonial Hospital Ex- perience, by Organs and Parts 738 292 " 1906-1911 Colonial Hospital Ex- perience, by Race. . . 738 293 Hawaii 1902-1913 Persons 739 294 " 1911-1913 By Race 739 295 " 1911-1913 By Organs and Parts, according to Race. . . 739 296 America By Countries 740 Canada 297 Pro\nnce of Ontario 1881-1913 Persons 741 298 Toronto 1881-1913 Persons 741 299 " 1881-1913 Males 742 300 " 1881-1913 Females 742 301 Montreal 1881-1913 Persons 743 302 City of Quebec 1894-1912 Persons 744 303 Winnipeg 1910-1913 By Sex 744 304 British Columbia 1901-1913 Persons 745 305 Nova Scotia 1910-1913 By Sex 745 306 Prince Edward Island 1913-1914 Persons 745 New Brunswick 307 St. John 1891-1913 Persons 746 308 Newfoundland and Labrador. . . 1906-1913 Persons 746 309 Bermuda Islands 1891-1913 Persons 747 310 " " 1891-1913 Males 747 311 " " 1891-1913 Females 748 312 Jamaica 1881-1913 Persons 748 313 " 1881-1913 Males 749 314 " 1881-1913 Females 749 315 Windward and Leeward Islands . 1901-1912 Persons 750 590 APPENDIX G Table Country Period Title Page 316 Trinidad 1890-1913 Persons 750 317 Barbados 1899-1903 Hospital Experience. . 751 Danish West Indies 318 St. Thomas 1901-1914 Persons 751 319 British Honduras ." . . . 1894-1913 Persons 751 320 British Guiana 1896-1913 Persons 752 321 " " 1896-1913 Males 752 322 " " 1896-1913 Females 753 Dutch Guiana 323 Paramaribo 1903-1912 Persons 753 324 " 1903-1912 By Sex 754 325 Cuba 1901-1913 Persons 754 326 " 1902-1913 By Sex 755 327 " 1908-1912 By Organs and Parts, according to Sex 755 328 " 1908-1912 By Organs and Parts, according to Race . . . 756 329 Havana 1899-1912 Persons 756 330 Porto Rico 1910-1913 Persons 757 331 " " 1910-1913 By Organs and Parts 757 Mexico 332 City of Mexico 1905-1913 By Sex 758 333 " " 1908-1912 By Organs and Parts, according to Sex 759 334 Costa Rica 1901-1912 Persons 759 335 Nicaragua 1908-1911 Persons 759 Salvador 336 San Salvador 1912 By Organs and Parts 760 337 Venezuela 1905-1912 Persons 760 Colombia 338 Bogota 1912-1913 Persons 760 Ecuador 339 Guayaquil 1910-1912 Persons 760 Bolivia 340 La Paz 1900-1909 Persons 760 Peru 341 Lima 1904 By Organs and Parts, according to Sex 761 342 Trujillo 1903-1913 Persons 761 Brazil 343 City of Rio de Janeiro 1891-1913 Persons 762 344 Fed. Dist. of Rio de Janeiro 1903-1913 Persons 762 345 " " " 1906-1910 By Organs and Parts, Males 763 346 " " " 1906-1910 By Organs and Parts, Females 763 347 City of Bahia 1897-1912 Persons 764 348 " " 1900-1911 Males 764 349 " " 1900-1911 Females 765 350 " " 1904-1908 By Organs and Parts, according to Sex 765 591 APPENDIX G Table Country ' Period Title Page Brazil {continued) 351 City of Sao Paulo 1896-1913 Persons 766 352 " " " 1901-1913 Males 766 353 " " " 1901-1913 Females 766 354 State of Parana 1906-1910 • Persons 767 355 Pelotas 1906-1913 Persons 767 356 Bello Horizonte 1910-1912 Persons 767 Argentine Republic 357 Province of Buenos Aires. . . 1895-1912 Persons 767 358 " " " ...1895-1912 Males 768 359 " " " . . .1895-1912 Females 768 360 City of Buenos Aires 1882-1913 Persons 769 361 " " " 1896-1913 Males 769 362 " " " 1896-1913 Females 770 363 " " " 1907-1911 By Organs and Parts, according to Sex 770 364 Rosario de Santa Fe 1904-1913 Persons 771 365 " " 1904-1911 Males 771 366 " " 1904-1911 Females 771 367 Province of Tucuman 1901-1912 Persons 771 368 Santiago del Estero 1891-1913 Persons 772 369 Chile 1892-1912 Persons 772 370 Prov. of Santiago de Chile . . 1904-1912 Persons 773 371 City of Santiago de Chile . . 1898-1909 Persons 773 372 " " " . . 1898-1902 By Organs and Parts 773 373 Uruguay 1891-1913 Persons 774 374 " 1905-1912 Males 774 375 " 1905-1912 Females 774 376 " 1906-1910 By Organs and Parts, according to Sex .... 775 377 Montevideo 1903-1913 Persons 775 378 " 1907-1911 By Organs and Parts 775 592 APPENDIX G Deaths Rate per from 100,000 Cancer Population 3,018 33.4 148,447 54.4 251,438 65.7 20,345 73.0 1,096,716 76.6 1,519,964 71.6 Table 1 Mortality from Cancer in the Civilized World, 1908-1912 Population Africa 9,041,866 Asia 272,814,962 America 382,549,311 Australasia 27,886,740 Europe 1,431,996,861 Total 2,124,289,740 Population, 1911: 439,699,139. Table 2 Mortality from Cancer, by Countries, 1901-1905 Compared with 1906-1910 Rate per 100, 1901-1905 Cuba 33.7 Uruguay 53.9 Scotland 84.8 Ontario 51.3 Brazil* 33.4 Italy 55.2 Ireland 68.5 Japan 54.0 Australian Commonwealth 62.5 Spain 44.4 Hungary 39.1 France* 92.1 British Columbia 30.3 German Empire 77.7 England and Wales 86.7 Jamaica 16.8 New Zealand 67.4 United States 67.9 Denmark* 129.1 Holland 97.8 Austria 74.7 Sweden* 102.2 Norway 94.9 Argentine Republicf 70.1 Switzeriand 128.3 Total 67.7 *Cities only. fProvince and city of Buenos Aires only. Table 3 Crude and Standardized Cancer Mortality Rates per 100,000 of Population Selected Countries, 1908-1912 000 Population Percentage of 1906-1910 Increase 43.3 28.5 66.5 23.4 99.7 17.6 60.1 17.2 39.0 16.8 63.6 15.2 78.8 15.0 62.0 14.8 70.3 12.5 49.8 12.2 43.6 11.5 102.7 11.5 33.4 10.2 84.2 8.5 94.0 8.4 18.1 7.7 72.1 7.0 72.6 6.9 137.3 6.4 103.5 5.8 78.3 4.8 104.5 2.2 96.6 1.8 71.3 1.7 125.9 -1.1 74.3 9.7 Crude Standardized Rate Rate* Switzeriand 127.1 107.8 Bavaria 113.8 104.9 Holland 106.4 92.6 England and Wales. 97.6 89.5 Norway 97.4 75.5 Ireland 81.2 61.9 Crude Standardized Rate Rate* U. S. Reg. Area 74.7 73.9 Australia 74.3 76.2 Uruguay Q5.5 98.8 Italy 65.2 63.5 Japan 64.3 58.5 Cuba 44.4 60.3 *Standardized on the basis of the standard million of England and Wales, 1901. 593 APPENDIX G Table 4 Mortality from Cancer in Countries of Europe Deaths Rate per Population from 100,000 Cancer Population Austria 141,462,903 113,221 80.0 Belgium 36,936,410 24,712 66.9 Channel Islands 208,900 227 108.7 Denmark 5,453,322 7,747 142.1 England and Wales 178,980,717 174,602 97.6 France 196,878,000 148,662 75.5 German Empire 318,876,524 277,710 87.1 Gibraltar 97,823 81 82.8 Greece 2,117,670 1,100 51.9 Holland 29,479,395 31,375 106.4 Hungary 104,006,496 47,347 45.5 Ireland 21,925,004 17,796 81.2 Isleof Man 261,530 339 129.6 Italy 171,995,665 112,087 65.2 Malta 1,056,196 512 48.5 Norway 11,774,100 11,461 97.4 Portugal 29,060,580 6,504 22.4 Roumania 6,410,450 3,940 61.5 Russia 8,624,796 7,812 90.6 Scotland 23,686,521 24,399 103.0 Serbia 13,876,836 1,669 12.0 Spain 97,705,000 51,135 52.3 Sweden 6,685,581 7,022 105.0 Switzerland 18,686,442 23,228 124.3 Turkey. , 5,750,000 2,001 34.8 Total 1,431,996,861 1,096,716 76.6 Population, 1911: 291,384,190. NOTES TO TABLE 4 Austria 1908-1912 Belgium 1908-1912 Channel Islands Guernsey, 1909-1913 Denmark All cities, 1908-1912 England and Wales 1908-1912 France 1906-1910 German Empire 1908-1912 Gibraltar 1908-1912 Greece 12 cities, 1904-1908 Holland 1908-1912 Hungary 1908-1912 Ireland 1908-1912 Isleof Man 1908-1912 Italy 1908-1912 Malta 1908-1912 Norway 1908-1912 Portugal 1906-1910 Roumania All cities, 1907-1911 Russia Moscow, 1910-1912, Petrograd, with suburbs, 1911-1912 Scotland 1908-1912 Serbia 1905-1909 Spain 1908-1912 Sweden. All cities, 1907-1911 Swdtzerland 1908-1912 Turkey Constantinople, 1908-1912 594 APPENDIX G Table 5 Mortality from Cancer in Countries of Europe 1896-1910 1896-1900 Deaths Rate per Population from 100,000 Cancer Population England and Wales 157,609,380 126,206 80.1 Scotland 21,725,362 16,753 77.1 Ireland 22,561,358 13,100 58.1 Norway 10,769,800 9,234 85.7 Denmark* ' 4,477,360 5,325 118.9 German Empire. .. 254,148,664 179,863 70.8 Holland 25,166,349 23,134 91.9 Switzerland 16,127,599 20,544 127.4 Austria 127,026,960 87,570 68.9 Hungary 75,364,810t 23,134t 30.7 Italy 159,631,670 81,332 50.9 France* 65,951,116 64,185 97.3 Total 940,560,428 650,380 69.1 1901-1905 Deaths Population from Cancer 166,489,397 144,351 22,676,880 19,223 22,106,804 15,148 11,314,400 10,732 4,923,381 6,357 280,410,950 217,866 26,840,255 26,239 17,142,770 21,995 133,280,624 99,542 98,225,662 38,366 164,281,879 90,757 70,461,200 64,865 Rate per 100,000 Population 86.7 84.8 68.5 94.9 129.1 77.7 97.8 128.3 74.7 39.1 55.2 92.1 1,018,154,202 755,441 74.2 1900-1910 Deaths Rate per Population from 100,000 Cancer Population England and Wales. 175,333,013 164,790 94.0 Scotland 23,394,061 23,316 99.7 Ireland 21,942,708 17,299 78.8 Norway 11,606,600 11,213 96.6 Denmark* 5,288,066 7,259 137.3 German Empire .. . 310,481,457 261,311 84.2 Holland 28,725,355 29,727 103.5 Switzerland 18,237,395 22,963 125.9 Austria 139,193,082 108,947 78.3 Hungary 102,167,372 44,550 43.6 Italy 169,120,165 107,575 63.6 France* 71,714,000 73,643 102.7 Total 1,077,203,274 872,593 81.0 Note: From 1896-1900 to 1901-1905 the cancer mortality increased 5.05 per 100,000 of population, or 7.3 per cent. From 1901-1905 to 1906-1910 it increased 6.81 per 100,000 of population, or 9.2 per cent. ♦Cities only. fFour years only (1897-1900). 595 APPENDIX G Table 6 Table 7 Mortality from Cancer in England Mortality from Cancer in England and Wales and Wales, Males 1881-19 13 Deaths Rate per 1881-19 13 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 26.046,142 13,542 52.0 1881 12,673,435 4,611 36.4 1882 26,334,942 14,057 53.4 1882 12,808,460 4,685 36.6 1883 26,626,949 14,614 54.9 1883 12,944,923 4,967 38.4 1884 26,922,192 15,198 56.5 1884 13,082,837 5,346 40.9 1885 27,220,706 15,560 57.2 54.8 1885 1881-1885 13,222,216 5,495 41.6 1881-1885 133,150,931 72,971 64,731,871 25,104 38.8 1886 27,522,532 16,243 59.0 1886 13,363,079 5,754 43.1 1887 27,827,706 17,113 61.5 1887 13,505,441 6,262 46.4 1888 28,136,258 17,506 62.2 1888 13,649,314 6,284 46.0 1889 28,448,239 18,654 65.6 1889 13,794,721 6.891 50.0 1890 28,763,673 19,433 67.6 63.2 1890 1886-1890 13,941,671 7,137 51.2 1886-1890 140,698,408 88,949 68,254,226 32,328 47.4 1891 29,085,819 20,117 69.2 1891 14,092,535 7,294 51.8 1892 29,421,392 20,353 69.2 1892 14,252,190 7,547 53.0 1893 29,760,842 21,135 71.0 1893 14,413,657 7,908 54.9 1894 30,104,201 21,422 71.2 1894 14,576,948 8,077 55.4 1895 30,451,528 22,945 75.3 71.2 1895 1891-1895 14,742,091 8,628 58.5 1891-1895 148,823,782 105,972 72,077,421 39,454 54.7 1896 30,802,858 23,521 76.4 1896 14,909,104 9,216 61.8 1897 31,158,245 24,443 78.4 1897 15,078,010 9,573 63.5 1898 31,517,725 25,196 79.9 1898 15,248,823 9,932 65.1 1899 31,881,365 26,325 82.6 1899 15,421,578 10,337 67.0 1900 32,249,187 26,721 82.9 80.1 1900 1896-1900 15,596,283 10,475 67.2 1896-1900 157,609,380 126,206 76,253,798 49,533 65.0 1901 32,612,134 27,487 84.3 1901 15,769,478 10,891 69.1 1902 32,951,455 27,872 84.6 1902 15,933,989 11,098 69.6 1903 33,294,308 29,089 87.4 1903 16,100,211 11,799 73.3 1904 33,640,736 29,682 88.2 1904 16,268,166 12,086 74.3 1905 33,990,764 30,221 144,351 88.9 86.7 1905 1901-1905 16,437,866 12,470 75.9 1901-1905 166,489,397 80,509,710 58,344 72.5 1906 34,344,429 31,668 92.2 1906 16,609,330 13,257 79.8 1907 34,701,776 31,745 91.5 1907 16,782,579 13,199 78.6 1908 35,062,847 32,717 93.3 1908 16,957,634 13,901 82.0 1909 35,427,072 34,053 96.1 1909 17,134,508 14,263 83.2 1910 35,796,289 34,607 96.7 94.0 1910 1906-1910 17,313,221 14,843 85.7 1906-1910 175,333,013 164,790 84,797,272 69,463 81.9 1911 36,162,046 35,902 99.3 1911 17,490,286 15,589 89.1 1912 36,531,203 37,323 102.2 1912 17,668,999 16,188 91.6 1913 36,919,339 38,939 105.5 1913 17,857,014 16,918 94.7 Source : Annual Reports of th e Regis- Source: Annual Reports of th e Regis- trar-General of Births, Deaths and Mar- trar-General of Births, Deaths and ]\lar- riages in England and Wales. riages in England and Wales. 596 APPENDIX G Table f Mortality from Cane and Wales, F 1881-191 5 :er in Er emales 3 Deaths from Cancer '. 8,931 9,372 9,647 9,852 10,065 Igland Rate per 100,000 ■Population 66.8 69.3 70.5 71.2 71.9 70.0 74.1 75.8 77.5 80.3 83.0 78.2 85.5 84.4 86.2 85.9 91.1 86.7 90.0 92.5 93.8 97.1 97.6 94.2 98.5 98.6 100.6 101.3 101.1 .100.0 103.8 103.5 103.9 108.2 106.9 105.3 108.8 112.0 115.5 e Regis- id Mar- Mortali an Ages Under 35 35-44 45-54 55-64 65-74 75-84 85 and ov€ All ages Under 35 35-44 45-54 55-64 65-74 75-84 85 and ove All ages Under 35 35-44 45-54 55-64 65-74 75-84 85 and ovc All ages Source: trar-Genei riages in I Table ty from Can( d Wales, ace Age and 1901-191 9 ;er in Er ording t Sex 10 Deaths from Cancer 12,595 27,992 62,287 87,997 80,605 33,557 4,108 Igland o Population 13,372,707 13,526,482 13,682,026 13,839,355 13,998,490 Year 1881 1882 1883 1884 1885 TOTAL Population 227,920,310 43,957,297 31,966,672 21,101,120 12,099,817 4,217,306 >r 559,888 Rate per 100,000 'opulation 5.5 63.7 194.8 1881-1885 1886 1887 68,419,060 14,159,453 14,322,265 14,486,944 14,653,518 14,822,002 47,867 10,489 10,851 11,222 11,763 12,296 417.0 666.2 795.7 733.7 1888 1889 1890 341,822,410 MALES 111,499,560 21,222,110 15,363,631 9,911,807 5,367,518 1,739,029 r 203,327 309,141 5,465 8,773 23,779 38,675 35,831 13,810 1,474 90.4 1886-1890 1891 1892 1893 1894 1895 72,444,182 14,993,284 15,169,202 15,347,185 15,527,253 15,709,437 56,621 12,823 12,806 13,227 13,345 14,317 4.9 41.3 154.8 390.2 667.6 794.1 724.9 1891-1895 1896 1897 1898 1899 1900 76,746,361 15,893,754 16,080,235 16,268,902 16,459,787 16,652,904 66,518 14,305 14,870 15,264 15,988 16,246 165,306,982 127,807 FEMALES 116,420,750 7,130 22,735,187 19,219 16,603,041 38,508 11,189,313 49,322 6,732,299 44,774 2,478,277 19,747 ;r 356,561 2,634 77.3 6.1 84.5 231.9 440.8 1896-1900 1901 81,355,582 16,842,656 17,017,466 17,194,097 17,372,570 17,552,898 76,673 16,596 16,774 17,290 17,596 17,751 665.1 796.8 738.7 1902 1903 1904 1905 176,515,428 181,334 Annual Reports of th al of Births, Deaths a England and Wales. 102.7 e Regis- ad Mar- 1901-1905 1906 1907 1908 1909 1910 85,979,687 17,735,099 17,919,197 18,105,213 18,293,164 18,483,068 86,007 18,411 18,546 18,816 19,790 19,764 1906-1910 90,535,741 95,327 1911 18,672,360 20,313 1912 18,862,264 21,135 1913 19,062,325 22,021 Source: Annual Reports of th trar-General of Births, Deaths ai riages in England and Wales. 597 APPENDIX G Table 10 Mortality from Cancer in England and Wales, by Organs and Parts according to Sex, 1908-1912 Organ or Part Deaths from Cancer Lips 1,134 Tongue 4,278 Mouth 1,493 Jaw 2,149 Pharynx 1,438 CEsophagus 5,298 Stomach 15,780 Liver and gall-bladder 8,406 Peritoneum and mesentery 676 Intestines 6,985 Rectum 7,452 Pancreas 1,486 Ovaries and fallopian tube Uterus Breast 118 Skin 2,076 Larynx 1,662 Lungs and pleura 1,193 Kidneys and suprarenal glands . . . 774 Bladder 2,245 Prostate 1,665 Brain 546 Other organs 6,696 Not specified 1,234 All organs 74,784 MALES Rate per 100,000 Population 1.3 4.9 1.7 2.5 1.7 6.1 18.2 9.7 0.8 8.1 8.6 1.7 0.1 2.4 1.9 1.4 0.9 2.6 1.9 0.6 7.7 1.4 86.4 Deaths Rate per from 100,000 Cancer Population 105 0.1 400 0.4 221 0.2 726 0.8 406 0.4 1,707 1.8 14,437 15.6 12,571 13.6 1,452 1.6 9,581 10.4 6,018 6.5 1,462 1.6 2,221 2.4 19,673 21.3 17,189 18.6 1,332 1.4 486 0.5 855 0.9 766 0.8 978 1.1 420 0.5 6,770 6.2 1,042 1.1 99,818 108.0 Males, 45 years and over, 20.57 per cent, of population. Females, 45 years and over, 22.10 per cent, of population. Source: Annual Reports of the Registrar-General of Births, Deaths and Marriages, in England and Wales. 598 APPENDIX G Table 11 Mortality from Cancer in England and Wales, by Organs and Parts, Males 1897-1900 Compared with 1901-1910 Organ or Part 1897 Deaths from Cancer 997 647 508 Skin Lips Mouth Tongue 2,124 Jaw 1,071 Lymphatic glands of neck 1,084 Pharynx and throat 891 Larynx 740 Lungs 536 (Esophagus 2,358 Stomach 8,369 Pancreas 550 Liver and gall-bladder 5,532 Rectum 3,672 Other intestines. .' 2,734 Peritoneum 395 Kidney 405 Bladder and urethra 1,189 Breast 79 Male generative organs 1,015 Other organs 3,566 Not specified 1,855 All organs ■1900 Rate per 100,000 Popuhilioii 1.63 1.05 0.83 3.46 1.75 1.77 1.45 1.21 0.87 3.84 13.64 0.90 9.02 5.99 4.46 0.64 0.66 1.94 0.13 1.65 5.81 3.02 40,317 65.72 1901- Deaths from Cancer 2,945 2,001 2,241 7,092 3,697 3,585 2,967 2,518 1,688 8,406 27,324 2,391 15,823 12,963 10,583 1,076 1,381 3,960 236 3,815 9,930 1,185 1910 Rate per 100,000 Population 1.78 1.21 1.36 4.29 2.24 2.17 1.79 1.52 1.02 5.09 16.53 1.45 9.57 7.84 6.40 0.65 0.84 2.40 0.14 2.31 5.99 0.72 127,807 77.31 Percentage of Increase 9.2 15.2 63.9 24.0 28.0 22.6 23.4 25.6 17.2 32.6 21.2 61.1 6.1 30.9 43.5 1.6 27.3 23.7 7.7 40.0 3.1 —76.2 17.6 Source: Annual Reports of the Registrar-General of Births, Deaths and Marriages in England and Wales. 599 APPENDIX G Table 12 Mortality from Cancer in England and Wales, by Organs and Parts, Females 1897-1900 Compared with 1901-1910 Organ or Part 1897- Deaths from Cancer 608 74 115 271 397 405 334 Skin Lips Mouth Tongue Jaw Lymphatic glands of neck Pharynx and throat Larynx 282 Lungs 363 Oesophagus 852 Stomach 8,355 Pancreas 529 Liver and gall-bladder 8,654 Rectum.... 3,240 Other intestines 3,597 Peritoneum 1,050 Kidney 446 Bladder and urethra 539 Breast 9,790 Uterus 14,309 Ovary 1,053 Other organs 4,248 Not specified 2,857 All organs 62,368 1900 Rate per 100,000 Population 0.93 0.11 0.18 0.41 0.61 0.62 0.51 0.43 0.55 1.30 12.76 0.81 13.22 4.95 5.50 1.60 0.68 0.82 14.96 21.86 1.61 6.49 4.36 95.27 1901-1910 Deaths from Cancer 2,053 169 370 854 1,335 1,102 831 834 1,317 2,804 25,814 2,268 24,021 10,819 14,342 2,634 1,411 1,688 30,493 39,562 3,617 11,378 1,628 Rate per 100,000 Population 1.16 0.10 0.21 0.48 0.76 0.62 0.47 0.47 0.75 1.59 14.62 1.28 13.61 6.13 8.13 1.49 0.80 0.96 17.27 22.41 2.05 6.45 0.92 181,334 102.73 Percentage of Increase 24.7 -9.1 16.7 17.1 24.6 0.0 -7.8 ■ 9.3 36.4 22.3 14.6 58.0 3.0 23.8 47.8 -6.9 17.6 17.1 15.4 2.5 27.3 -0.6 -78.9 7.8 Source: Annual Reports of the Registrar-General of Births, Deaths and Marriages in England and Wales. 600 APPENDIX G Table 13 Mortality from Cancer in England and Wales Relative Cancer Mortality of Females, by Organs and Parts 1901-1910 Rate per 100,000 Population Organ or Part Males Females Breast.. 0.14 17.27 Generative organs 2.31 24.46 Peritoneum 0.65 1.49 Liver and gall-bladder 9.57 13.61 Other intestines 6.40 8.13 Kidney 0.84 0.80 Stomach 16.53 14.62 Pancreas 1.45 1.28 Rectmn 7.84 6.13 Lungs 1.02 0.75 Skin 1.78 1.16 Bladder and urethra 2.40 0.96 Jaw 2.24 0.76 (Esophagus 5.09 1.59 Larynx 1.52 0.47 Lymphatic glands of neck 2.17 0.62 Pharynx and throat 1.79 0.47 Mouth 1.36 0.21 Tongue 4.29 0.48 Lips 1.21 0.10 All organs 77.31 102.73 Relative Mortality of Females 12,336 1,059 229 142 127 95 78 74 65 40 34 31 31 29 26 15 11 133 Note: In this table the mortality of males from cancer of any organ or part is taken as 100 and the corresponding mortality of females is given accordingly. Table 14 Mortality from Cancer of the Female Breast in England and Wales 1903-1912 Deaths from Rate per Female Cancer of 100,000 Year Population the Breast Population 1903 17,194,097 2,948 17.1 1904 17,372,570 2,997 17.3 1905 17,552,898 2,944 16.8 1906 17,735,099 2,997 16.9 1907 17,919,197 3,162 17.6 1903-1907 87,773,861 15,048 17.1 1908 18,105,213 3,221 17.8 1909 18,293,164 3,377 18.5 1910 18,483,068 3,428 18.5 1911 18,672,360 3,427 18.4 1912 18,862,264 3,736 19.8 1908-1912 92,416,069 17,189 18.6 Source: Annual Reports of the Registrar-General of Births, Deaths and Marriages, in England and Wales. 601 APPENDIX G Table 15 Comparative Mortality from Cancer in England and Wales, Urban and Rural, by Organs and Parts, according to Sex, 1911-1912 TOTAL Urban Organ or Part Deaths from Cancer Buccal cavity 3,677 Stomach and liver 18,831 Peritoneum, intestines, rectum. . . 10,733 Female generative organs 7,527 Breast 5,647 Skin 1,345 Other or not specified 8,983 Rate per 100,000 Population 6.5 33.2 18.9 13.3 9.9 2.4 15.8 All organs 56,743 Buccal ca\'ity 3,186 Stomach and liver 9,784 Peritoneum, intestines, rectum . . . 4,934 Breast 32 Skin 850 Other or not specified 5,594 100.0 MALES All organs 24,380 11.7 36.0 18.1 0.1 3.1 20.6 89.6 FEMALES Buccal cavity 491 Stomach and liver 9,047 Peritoneum, intestines, rectum.. . 5,799 Generative organs 7,527 Breast 5,615 Skin 495 Other or not specified 3,389 All organs 32,363 1.7 30.6 19.6 25.5 19.0 1.7 11.4 109.5 POPULATION, 1911-1912 Urban Males 27,195,707 Females 29,562,270 Total 56,757,977 Rural Deaths Rate per from 100,000 Cancer Population 971 6.1 5,981 37.5 3,401 21.3 1,667 10.5 1,558 9.8 507 3.2 2,397 15.0 16,482 3,070 1,692 10 313 1,486 7,397 145 2,911 1,709 1,667 1,548 194 911 9.085 Rural 7,963,578 7,972,354 15,935,932 103.4 10.4 38.6 21.2 0.1 3.9 18.7 92.9 1.8 36.5 21.4 20.9 19.4 2.4 11.4 113.9 Source: Annual Reports of the Registrar-General of Births, Deaths and Marriages in England and Wales. Note: If standardized, the urban cancer death rates are somewhat higher than the rural rates. 602 APPENDIX G Table 15a Cancer of the Ovary, according to Age and Conjugal Condition England and Wales, 1911-1913 Ages Unmarried 25-29 0.9 30-34 1.4 35-39 3.7 40-44 7.6 45-49 14.2 50-54 15.0 55-59 21.8 60-64 13.7 65-69 17.4 70-74 17.8 75-79 21.1 80-84 3.1 85 and over. . 6.3 15 and over . 6.0* ER 100,000 Relative Rates TION Ages 25-29 Taken as 100 Married or Married or Married or Widowed Unmarried Widowed Unmarried Widowed 0.7 0.2 100 100 1.0 0.4 156 143 2.1 1.6 411 300 3.5 4.1 844 500 5.9 8.3 1,578 843 8.3 6.7 1,667 1,186 8.6 13.2 2,422 1,229 9.7 4.0 1,522 1,386 10.5 6.9 1,933 1,500 9.4 8.4 1,978 1,343 9.0 12.1 2,344 1,286 6.0 2.9 344 857 4.6 1.7 700 657 3.1* 2.9 667 443 Source: Seventy-sixth Annual Report of the Registrar-General of Births, Deaths and Marriages in England and Wales. *Standardized to a million of persons aged 15 years and upwards, 1901. Table 15b Cancer of the Uterus, according to Age and Conjugal Condition England and Wales, 1911-1913 Death Rate per 100,000 OF Population Married or Ages Unmarried Widowed 25-29 0.7 2.0 30-34 3.1 6.8 35-39 5.0 18.7 40-44 17.2 37.4 45-49 25.0 58.1 50-54 39.7 77.3 55-59 61.3 87.3 60-64 61.1 96.7 65-69 64.6 97.0 70-74 62.7 91.7 75-79 84.4 92.8 80-84 102.0 73.0 85 and over.. 50.4 58.4 15 and over.. 16.9* 29.3* Excess in Rates Unmarried 29.0 Married or Widowed 1.3 3.7 13.7 20.2 33.1 37.6 26.0 35.6 32.4 29.0 8.4 8.6 12.4 Relative Rates Ages 25-29 Taken as 100 Married or Widowed Unmarried 100 443 714 2,457 3,571 5,671 8,757 8,729 9,229 8,957 12,057 14,571 7,200 2,414 100 340 935 1,870 2,905 3,865 4,365 4,835 4,850 4,585 4,640 3,650 2,920 1,465 Source: Seventy-sixth Annual Report of the Registrar-General of Births, Deaths and Marriages in England and Wales. *Standardized to a million of persons aged 15 years and upwards, 1901. 603 APPENDIX G Table 15c Cancer of the Breast, according to Age and Conjugal Condition England and Wales, 1911-1913 Death Rate PER 100,000 Excess IN Rates Relative Rates OF Population Ages 25-29 Taken as 100 Married or Married or Married or Ages Unmarried Widowed Unmarried Widowed Unmarried Widowed 25-29 . 0.4 0.7 0.3 100 100 30-34 3.2 4.1 0.9 800 586 35-39 . 12.9 12.6 0.3 3,225 1,800 40-44 . 29.9 26.8 3.1 7,475 3,829 45-49 . 55.0 41.8 13.2 13,750 5,971 50-54 . 75.5 51.7 23.8 18,875 7,386 55-59 . 102.3 65.7 36.6 25,575 9,386 60-64 . 118.9 73.7 45.2 29,725 10,529 65-69 . 142.3 81.2 61.1. 35,575 11,600 70-74 . 180.6 111.7 68.9 45,150 15,957 75-79 . 200.5 134.6 65.9 50,125 19,229 80-84 . 225.6 156.2 69.4 56,400 22,314 85 and over . . 308.8 191.6 117.2 77,200 27,371 15 and over . . 34.6* 23.8* 10.8 8,650 3,400 Source: Seventy-sixth Annual Report of the Registrar-General of Births, Deaths and Marriages in England and Wales. *Staiidardized to a million of persons aged 15 years and upwards, 1901. Table 15d Mortality from Cancer, Fistula and Gangrene in the City of London 1649-1758 Deaths from Deaths from Cancer, Fistula Per Cent, of All Causes and Gangrene All Causes 1649-1658 117,344 370 0.32 1659-1668* 132,972 466 0.35 1669-1678 188,015 478 0.25 1679-1688 221,446 597 0.27 1701-1708 168,191 549 0.33 1709-1718 231,714 702 0.30 1719-1728 272,240 710 0.26 1729-1738 265,165 564 0.21 1739-1748 260,517 498 0.19 1749-1758 214,406 460 0.21 Source : A Collection of the Yearly Bills of Mortality from 1657 to 1758, London, 1759. Note: No data available for 1689-1700. *Data for 1665 and 1666 excluded. Plague years. 604 APPENDIX G Table 16 Table 17 Mortality from Cancer in London Mortality from Cancer in London 1881-1913 Males - 1881-1913 Year Population Deaths from Cancer Rate per 100,000 'opulation Year Population Deaths from Cancer Rate per 100,000 j'opulation 1881 3,840,239 2,332 60.7 1881 1,808,753 755 41.7 1882 3,880,005 2,461 63.4 1882 1,828,258 779 42.6 1883 3,919,771 2,561 65.3 1883 1,847,388 804 43.5 1884 3,959,537 2,604 65.8 1884 1,866,922 915 49.0 1885 3,999,303 19,598,855 2,622 65.6 64.2 1885 1,886,072 909 48.2 12,580 1881-1885 1881-1885 9,237,393 4,162 45.1 1886 4,039,069 2,688 66.5 1887 4,078,835 2,909 71.3 1886 1,905,633 967 50.7 1888 4,118,601 2,932 71.2 1887 1,925,618 1,089 56.6 1889 4,158,367 3,029 72.8 1888 1,945,215 1,058 54.4 1890 4,198,133 3,286 78.3 1889 1890 1,964,828 1,984,038 1.078 1,194 54.9 60.2 1886-1890 20,593,005 14,844 72.1 1886-1890 9,725,332 5,386 55.4 1891 4,237,896 3.342 78.9 1892 4,268,727 3,246 76.0 1891 2,003,253 1,233 61.5 1893 4,299,558 3,462 80.5 1892 2,017,400 1,242 61.6 1894 4,330,389 3,523 81.4 1893 2,031,541 1,280 63.0 1895 4,361,220 3,705 85.0 1894 2,046,109 1,354 66.2 1895 2,060,240 1,423 69.1 1891-1895 21,497,790 17,278 80.4 1891-1895 10,158,543 6,532 64.3 1896 4,392,051 3,856 87.8 1897 4,422,882 3,963 89.6 1896 2,074,366 1,523 73.4 1898 4,453,713 4,133 92.8 1897 2,088,485 1,617 77.4 1899 4,484,544 4,293 95.7 1898 2,102,598 1,658 78.9 1900 4,515,375 4,348 96.3 1899 2,116,705 1,741 82.3 1900 2,130,805 1,790 84.0 1896-1900 22,268,565 20,593 92.5 1896-1900 10,512,959 8,329 79.2 1901 4,546,209 4,260 93.7 1902 4,544,878 4,591 101.0 1901 2,145,356 1,704 79.4 1903 4,543,547 4,716 103.8 1902 2,144,274 1,932 90.1 1904 4,542,216 4,677 103.0 1903 2,142,737 2,000 93.3 1905 4,540,885 4,691 103.3 1904 2,141,201 1,988 92.8 1905 2,139,665 1,986 92.8 1901-1905 22,717,735 22,935 101.0 1901-1905 10,713,233 9,610 89,7 1906 4,539,554 5,001 110.2 1907 4,538,223 4,899 107.9 1906 2,138,130 2,196 102.7 1908 4,536,892 5,045 111.2 1907 2,137,049 2,184 102.2 1909 4,535,561 5,128 113.1 1908 2,135,515 2,253 105.5 1910 4,534,230 5,115 112.8 1909 2,134,435 2,261 105.9 1910 2,132,902 2,340 109.7 1906-1910 22,684,460 25,188 111.0 1906-1910 10,678,031 11,234 105.2 1911 4,532,899 4,858 107.2 1912 4,531,572 5,176 114.2 1911 2,131,822 2,265 106.2 1913 4,530,245 5,260 114.9 1912 2,130,745 2,272 106.6 c^„^„^. ^^^,,c^T> ^^ „„4?4^T,„-D «™C^4-««« 1913 2,129,668 2,318 108.8 General of Births, Deaths and Marriages in England and Wales. Annual Report of the London County Counsel, 1913. Source : Annual Reports of the Registrar- General of Births, Deaths and Marriages in England and Wales. 605 APPENDIX G Table 18 Mortality from Cancer in London, Females 1881-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 2,031,486 1,577 77.6 1906 2,401,424 2,805 116.8 1882 2,051,747 1,682 82.0 1907 2,401,174 2,715 113.1 1883 2,072,383 1,757 84.8 1908 2,401,377 2,792 116.3 1884 2,092,615 1,689 80.7 1909 2,401,126 2,867 119.4 1885 2,113,231 1,713 81.1 81.2 1910 1906-1910 2,401,328 2,775 115.6 1881-1885 10,361,462 8,418 12,006,429 13,954 116.2 1886 2,133,436 1,721 80.7 1911 2,401,077 2,593 108.0 1887 2,153,217 1,820 84.5 1912 2,400,827 2,904 121.0 1888 2,173,386 1,874 86.2 1913 2,400,577 2,942 122.6 1889 2,193,539 1,951 88.9 1890 2,214,095 2,092 94.5 Source: Annual Reports of the Registrar- General of Births, Deaths and IV larriages 1886-1890 10,867,673 9,458 87.0 in England and Wales. 1891 2,234,643 2,109 94.4 1892 2,251,327 2,004 89.0 1893 2,268,017 2,182 96.2 1894 2,284,280 2,169 95.0 1895 2,300,980 2,282 99.2 94.8 1891-1895 11,339,247 10,746 1896 2,317,685 2,333 100.7 1897 2,334,397 2,346 100.5 1898 2,351,115 2,475 105.3 1899 2,367,839 2,552 107.8 1900 2,384,570 2,558 107.3 104.3 • 1896-1900 11,755,606 12,264 1901 2,400,853 2,556 106.5 1902 2,400,604 2,659 110.8 1903 2,400,810 2,716 113.1 1904 2,401,015 2,689 112.0 1905 2,401,220 2,705 112.7 111.0 1901-1905 12,004,502 13,325 606 APPENDIX G Table 19 Mortality from Cancer in Sheffield 1887-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1887 308,730 146 47.3 1901 410,151 255 62.2 1888 312,793 135 43.2 1902 414,506 300 72.4 1889 316,901 163 51.4 1903 418,906 303 72.3 1890 321,079 156 48.6 1904 423,355 317 74.9 1905 427,850 290 67.8 1887-1890 1,259,503 600 47.6 1901-1905 2,094,768 1,465 69.9 1891 325,547 150 46.1 1892 330,816 154 46.6 1906 432,395 346 80.0 1893 336,171 184 54.7 1907 436,986 363 83.1 1894 341,612 207 60.6 1908 441,630 347 78.6 1895 347,141 208 59.9 1909 446,321 403 90.3 1910 451,065 394 87.3 1891-1895 1,681,287 903 53.7 1906-1910 2,208,397 1,853 83.9 1896 352,760 225 63.8 1897 358,470 233 65.0 1911 455,817 379 83.1 1898 364,272 244 67.0 1912 466,408 371 79.5 1899 370,168 228 61.6 1913 471,662 419 88.8 1900 376,160 284 75.5 Source: Annual Reports of the Health 1896-1900 1,821,830 1,214 66.6 of the City of Sheffield. Table 20 Mortality from Cancer in Sheffield, Males 1887-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1887 153,871 43 27.9 1901 204,419 121 59.2 1888 155,896 42 26.9 1902 206,590 115 55.7 1889 157,943 56 35.5 1903 208,573 127 60.9 1890 160,026 52 32.5 1904 1905 210,577 212,599 137 108 65.1 50.8 1887-1890 627,736 193 30.7 1901-1905 1,042,758 608 58.3 1891 162,253 58 35.7 1892 164,879 64 38.8 1906 214,641 155 72.2 1893 167,548 57 34.0 1907 216,701 151 69.7 1894 170,259 79 46.4 1908 218,784 162 74.0 1895 173,015 76 43.9 1909 1910 220,884 223,007 167 172 75.6 leqi.iQQs 837,954 334 39.9 1906-1910 1,094,017 807 73.8 1896 175,816 84 47.8 1897 178,661 96 53.7 1911 225,037 179 79.5 1898 181,553 81 44.6 1912 230,266 177 76.9 1899 184,492 96 52.0 1913 232,860 172 73.9 1900 187,478 114 60.8 Source: Annual Reports of t 1896-1900 908,000 471 51.9 of the City of Sheffield. 40 607 APPENDIX G Table 21 Mortality from Cancer in Sheffield, Females 1887-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1887 154,859 103 66.5 1901 205,732 134 65.1 1888 156,897 93 59.3 1902 207,916 185 89.0 1889 158,958 107 67.3 1903 210,333 176 83.7 1890 161,053 104 64.6 1904 212,778 180 84.6 1905 215,251 182 84.6 1887-1890 631,767 407 64.4 1901-1905 1,052,010 857 81.5 1891 163,294 92 56.3 1892 165,937 90 54.2 1906 217,754 191 87.7 1893 168,623 127 75.3 1907 220,285 212 96.2 1894 171,353 128 74.7 1908 222,846 185 83.0 1895 174,126 132 75.8 1909 225,437 236 104.7 1910 228,058 222 97.3 1891-1895 843,333 569 67.5 1906-1910 1,114,380 1,046 93.9 1896 176,944 141 79.7 1897 179,809 137 76.2 1911 230,780 200 86.7 1898 182,719 163 89.2 1912 236,142 194 82.2 1899 185,676 132 71.1 1913 238,802 247 103.4 1900 188,682 170 90.1 Source: Annual Reports of the Health 1896-1900 913,830 743 81.3 of the City of Sheffield. Table 22 Mortality from Cancer in Liverpool 1889-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Catocer Population 1889 523,838 291 55.6 1901 686,332 593 86.4 1890 520,466 334 64.2 1902 707,027 613 86.7 1903 710,874 661 93.0 1891 518,302 346 66.8 1904 714,743 546 76.4 1892 1893 519,590 520,882 303 341 58.3 65.5 1905 721,864 620 85.9 1894 522,178 345 66.1 1901-1905 3,540,840 3,033 •85.7 1895 652,523 502 76.9 1906 1907 726,100 730,361 678 93 4 1891-1895 2,733,475 1,837 67.2 684 93.7 1908 734,648 658 89.6 1896 658,050 495 75.2 1909 738,960 694 93.9 1897 663,633 514 77.5 1910 743,295 745 100.2 1898 669,243 495 74.0 1899 674,912 530 78.5 1906-1910 3,673,364 3,459 94.2 1900 680,628 526 77.3 1911 1912 747,627 752,021 726 769 97 1 1896-1900 3,340,466 2,500 76.5 102.3 1913 756,553 717 94.8 Source: Annual Reports on the Health of the City of Liverpool. 608 APPENDIX G Table 23 Mortality from Cancer in Liverpool, Males 1889-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1889 254,166 121 47.6 1901 331,361 246 74.2 1890 252,478 122 48.3 1902 341,070 258 75.6 1903 342,712 269 78.5 1891 251,376 135 53.7 1904 344,363 235 68.2 1892 251,897 122 48.4 1905 347,578 278 80.0 1893 252,419 124 49.1 1894 252,943 136 53.8 1901-1905 1,707,084 1,286 75.3 1895 315,886 215 68.1 1906 349,399 282 80.7 1891-1895 1,324,521 732 55.3 1907 351,231 280 79.7 1908 353,072 298 84.4 1896 318,430 203 63.8 1909 354,922 287 80.9 1897 320,999 190 59.2 1910 356,782 342 95.9 1898 1899 323,579 326,185 210 222 64.9 68.1 1906-1910 1,765,406 1,489 84.3 1900 328,811 187 56.9 1911 358,637 329 91.7 1896-1900 1,618.004 1,012 62.5 1912 360,519 371 102.9 1913 362,470 347 95.7 Source: , Annual Reports on the Health of the City of Liverpool. Table 24 Mortality from Cancer in Liverpool, Females 1889-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Caincer Population Cancer Population 1889 269,672 170 63.0 1901 354,971 347 97.8 1890 267,988 212 79.1 1902 365,957 355 97.0 1903 368,162 392 106.5 1891 266,926 211 79.0 1904 370,380 311 84.0 1892 267,693 181 67.6 1905 374,286 342 91.4 1893 1894 268,463 269,235 217 209 80.8 77.6 1901-1905 1,833,756 1,747 95.3 1895 336,637 287 85.3 1906 376,701 396 105.1 1891-1895 1,408,954 1,105 78.4 1907 379,130 404 106.6 1908 381,576 360 94.3 1896 339,620 292 86.0 1909 384,038 407 106.0 1897 342,634 324 94.6 1910 386,513 403 104.3 1898 1899 345,664 348,727 285 308 82.5 88.3 1906-1910 1,907,958 1,970 103.3 1900 351,817 339 96.4 1911 388,990 397 102.1 1896-1900 1,728,462 1,548 89.6 1912 391,502 398 101.7 1913 394,083 370 93.9 Source: A.nnual Reports on the Health of the City of Liverpool. 609 APPENDIX G Table 25 Mortality from Cancer in Birmingham 1891-1912 Deaths Rate per ' Deaths Eate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 479,193 324 67.6 1906 523,586 460 87.9 1892 483,526 293 60.6 1907 523,850 419 80.0 1893 487,897 313 64.2 1908 524,114 441 84.1 1894 492,301 303 61.5 1909 524,378 424 80.9 1895 496,751 332 66.8 64.1 1910 1906-1910 525,762 469 89.2 1891-1895 2,439,668 1,565 2,621,690 2,213 84.4 1896 501,241 346 69.0 1911 526,030 467 88.8 1897 505,772 376 74.3 1912 850,947 792 93.1 1898 510,343 342 67.0 1899 514,956 386 75.0 Source: Annual Reports of the Medical 1900 519,610 368 70.8 71.2 Officer of Health for Birmingha 01. 1896-1900 2,551,922 1,818 1901 522,270 395 75.6 1902 522,533 383 73.3 1903 522,796 413 79.0 1904 523,059 400 76.5 1905 523,323 437 83.5 77.6 1901-1905 2,613,981 2,028 Table 26 Mortality from Cancer in Birmingham, by Sex 1904-1912 MALES FEMALES Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1904 252,481 172 68.1 1904 270,578 228 84.3 1905 252,608 186 73.6 1905 270,715 251 92.7 1906 252,735 210 83.1 1906 270,851 250 92.3 1907 252,862 168 66.4 1907 270,988 251 92.6 1908 252,990 193 76.3 1908 271,124 248 91.5 1909 253,117 170 67.2 1909 271,261 254 93.6 1910 253,785 236 93.0 77.2 1910 1906-1910 271,977 233 85.7 1906-1910 1,265,489 977 1,356,201 1,236 91.1 1911 253,915 184 72.5 1911 272,115 283 104.0 1912 405,646 349 86.0 1912 445,301 443 99.3 Source: Annual Reports of the Medical Officer of Health for Birmingham 610 APPENDIX G Table 27 Mortality from Cancer in Leeds 1893-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1893 381,157 229 60.1 1906 437,683 432 98.7 1894 387,259 265 68.4 1907 439,343 415 94.5 1895 393,387 299 76.0 1908 441,003 463 105.0 1909 442,663 449 101.4 1896 1897 399,535 405,716 308 308 77.1 75.9 1910 444,323 447 100.6 1898 411,895 292 70.9 1906-1910 2,205,015 2,206 100.0 1899 418,101 317 75.8 1900 424,322 369 87.0 1911 445,983 476 106.7 1912 1913 447,746 457,295 473 105 6 1896-1900 2,059,569 1,594 77.4 509 111.3 1901 429,383 348 81.0 Source: Annual Reports made to the 1902 431,043 353 81.9 Urban Sanitary Authority of the City of 1903 432,703 406 93.8 Leeds. 1904 434,363 379 87.3 1905 436,023 444 101.8 89.2 1901-1905 2,163,515 1,930 Table 28 Mortality from Cancer in Bristol 1894-1913 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1894 228,027 183 80.3 1906 354,329 307 86.6 1895 231,026 208 90.0 1907 354,965 317 89.3 1896 1897 1898 234,025 237,024 323,824 201 212 243 85.9 89.4 75.0 1908 1909 1910 355,601 356,237 356,873 306 357 340 86.1 100.2 95.3 1899 1900 327,825 332,076 289 266 88.2 80.1 1906-1910 1,778,005 1,627 91.5 1896-1900 1,454,774 1,211 83.2 1911 1912 357,509 359,400 387 402 108.2 111.9 1901 339,042 259 76.4 1913 361,362 396 109.6 1902 1903 1904 339,344 339,646 339,948 291 281 285 85.8 82.7 83.8 Source: Annual Reports of the Medical Officer of Health of Bristol. 1905 353,693 313 88.5 83.5 1901-1905 1,711,673 1,429 611 APPENDIX G Table 29 Table 30 Mortality from Cancer in Man- Mortality from Cancer in Man- Chester, 1891-1912 Chester, Males 1891-1912 Population Deaths from Rate per 100,000 Year Cancer Population Deaths Rate per Year Population from 100,000 1891 508,673 321 63.1 Cancer Population 1892 513,196 312 60.8 1891 245,486 119 48.5 1893 517,760 303 58.5 1892 247,514 105 42.4 1894 522,365 344 65.9 1893 249,612 121 48.5 1895 527,010 334 63.4 1894 251,728 124 49.3 1895 253,861 116 45.7 1891-1895 2,589,004 1,614 62.3 1891-1895 1,248,201 585 46.9 1896 531,697 358 67.3 1897 536,426 396 73.8 1896 256,012 125 48.8 1898 541,296 394 72.8 1897 258,081 152 58.9 1899 546,010 408 74.7 1898 260,418 164 63.0 1900 542,566 412 75.9 1899 262,576 144 54.8 1900 260,811 156 59.8 1896-1900 2,697,995 1,968 72.9 1896-1900 1,297,898 741 57.1 1901 546,408 425 77.8 1902 550,355 435 79.0 1901 262,549 180 68.6 1903 554,331 424 76.5 1902 264,336 185 70.0 1904 558,335 452 81.0 1903 268,352 185 68.9 1905 631,933 546 86.4 1904 270,275 192 71.0 1905 303,067 238 78.5 1901-1905 2,841,362 2,282 80.3 1901-1905 1,368,579 980 71.6 1906 646,066 562 87.0 1907 660,199 498 75.4 1906 309,853 242 78.1 1908 674,332 584 86.6 1907 316,631 206 65.1 1909 688,466 606 88.0 1908 323,410 267 82.6 1910 702,600 660 93.9 1909 330,188 266 80.6 1910 336,967 307 91,1 1906-1910 3,371,663 2,910 86.3 1906-1910 1,617.049 1,288 79.7 1911 716,734 750 104.6 1912 730,868 721 98.6 1911 344,490 332 96.4 1912 350,524 309 88.2 Source: Annual Reports on the Health of the City of Manchester. Source: Annual Reports on the Health of the City of Manchester. 612 APPENDIX G Table 31 Mortality from Cancer in Man- chester, Females 1891-1912 Year 1891 1892 1893 1894 1895 Population 263,187 265,682 268,148 270,637 273.149 1891-1895 1,340,803 1896 1897 1898 1899 1900 275,685 278,345 280,878 283,434 281,755 Deaths from Cancer 202 207 182 220 218 1,029 233 244 230 264 256 1896-1900 1,400,097 1,227 1901 1902 1903 1904 1905 283,859 286,019 285,979 288,060 328,866 245 250 239 260 308 1901-1905 1,472,783 1906 336,213 1907 343,568 1908 350,922 1909 358,278 1910 365,633 1,302 320 292 317 340 353 1906-1910 1,754,614 1,622 1911 1912 372,244 380,344 418 412 Rate per 100,000 Population 76.8 77.9 67.9 81.3 79.8 76.7 84.5 87.7 81.9 93.1 90.9 87.6 86.3 87.4 83.6 90.3 93.7 95.2 85.0 90.3 94.9 96.5 92.4 112.3 108.3 Source: Annual Reports on the Health of the City of Manchester. Table 32 Mortality from Cancer in Scotland 1881-1912 Year 1881 1883 1884 1885 Population 3,742,564 3,770,657 3,798,961 3,827,478 3,856,207 1886 1887 1888 1889 1890 3,885,155 3,914,318 3,943,701 3,973,305 4,003,132 1891 1892 1893 1894 1895 4,036,245 4,078,910 4,122,029 4,165,606 4,209,645 1896 1897 1898 1899 1900 4,254,153 4,299,132 4,344,589 4,390,530 4,436,958 1901 1902 1903 1904 1905 4,479,065 4,507,048 4,535,201 4,563,530 4,592,036 1906 1907 1908 1909 1910 4,620,720 4,649,586 4,678,629 4,707,858 4,737,268 1911 1912 4,766,678 4,796,088 Deaths from Cancer 1,914 2,056 2,037 2,110 2,173 1881-1885 18,995,867 10,290 2,313 2,373 2,450 2,643 2,428 1886-1890 19,719,611 12,207 2,703 2,715 2,816 2,928 2,993 1891-1895 20,612,435 14,155 3,013 3,212 3,453 3,572 3,503 1896-1900 21,725,362 16,753 3,662 3,711 3,798 3,920 4,132 1901-1905 22,676,880 19,223 4,509 4,551 4,611 4,782 4,863 1906-1910 23,394,061 23,316 4,948 5,195 Rate per 100,000 Population 51.1 54.5 53.6 55.1 56.4 54.2 59.5 60.6 62.1 66.5 60.7 61.9 67.0 66.6 68.3 70.3 • 71.1 68.7 70.8 74.7 79.5 81.4 79.0 77.1 81.8 82.3 83.7 85.9 90.0 84.8 97.6 97.9 98.6 101.6 102.7 99.7 103.8 108.3 Source: Annual Reports of the Registrar- General on the Births, Deaths and Mar- riages registered in Scotland. 613 APPENDIX G Table 33 Mortality from Cancer in Scotland, by Sex 1906-1912 MALES FEMALES Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1906 1907 1908 1909 1910 2,241,049 2,255,049 2,269,135 2,283,311 2,297,575 1,785 1,786 1,816 1,887 1,953 79.7 79.2 80.0 82.6 85.0 81.3 1906 1907 1908 1909 1910 1906-1910 2,379,671 2,394,537 2,409,494 2,424,547 2,439,693 2,724 2,765 2,795 2,895 2,910 114.5 115.5 116.0 119.4 119.3 1906-1910 11,346,119 9,227 12,047,942 14,089 116.9 1911 1912 2,311,839 2,326,103 2.046 2,075 88.5 89.2 1911 1912 2,454,839 2,469,985 2,902 3,120 118.2 126.3 Source: Annual Reports of the Registrar- General on the Births, Deaths and Mar- riages registered in Scotland. Table 34 Mortality from Cancer in Scotland, by Organs and Parts, according to Sex • 1906-1910 Organ or Part from Cancer Lips 125 Mouth 97 Tongue 457 Jaw 278 Pharynx and throat 200 Larynx 154 Lungs 151 (Esophagus 354 Stomach 2,471 Pancreas 131 Liver 985 Rectiun 651 Other intestines 1,102 Peritoneum 82 Kidney 86 Bladder and urethra 227 Breast 18 Male generative organs 234 Uterus Ovary Other organs 1,138 Not specified 286 MALES Deaths Rate per 100,000 Population 1.10 0.85 4.03 2.45 1.76 1.36 1.33 3.12 21.78 1.15 8.68 5.74 9.71 0.72 0.76 2.00 0.16 2.06 10.03 2..52 81.32 FEMALES Deaths Rate per from 100,000 Cancer Population 16 0.13 26 0.22 63 0.52 88 0.73 73 0.61 58 0.48 121 1.00 183 1.52 2,769 22.98 165 1.37 1,655 13.74 630 5.23 ],708 14.18 176 1.46 88 0.73 124 1.03 1,856 15.41 2,262 18.77 217 1.80 1,388 11.52 423 3.51 14,089 116.94 All organs 9,227 Source: Detailed Annual Reports of the Registrar-General of Births, Deaths and Mar- riages in Scotland. 614 APPENDIX G Table 35 Mortality from Cancer in Scotland Relative Mortality of Females, by Organs and Parts 1906-1910 Rate per 100,000 Population Organ or Part Males Females Breast 0.16 15.41 Generative organs 2.06 20.57 Peritoneum 0.72 1.46 Liver 8.68 13.74 Other intestines 9.71 14.18 Pancreas 1.15 1.37 Stomach 21.78 22.98 Kidney 0.76 0.73 Rectum 5.74 5.23 Lungs 1.33 1.00 Bladder and urethra 2.00 1.03 (Esophagus 3.12 1.52 Pharynx and throat 1.76 0.61 Larynx 1.36 0.48 Jaw 2.45 0.73 Mouth 0.85 0.22 Tongue 4.03 0.52 Lips 1.10 0.13 All organs 81.32 116.94 Relative Mortality of Females 9,631 999 158 146 119 106 96 91 75 52 49 35 35 30 26 13 12 144 Note: In this table the mortality of males from cancer of any organ or part is taken as 100 and the corresponding mortality of females is given accordingly. Table 36 Mortality from Cancer in Aberdeen 1899-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1899 151,425 145 95.8 1906 158,698 141 88.8 1900 152,464 132 86.6 1907 159,737 181 113.3 1908 160,776 178 110.7 1901 153,503 146 95.1 1909 161,815 182 112.5 1902 154,542 138 89.3 1910 162,854 161 98.9 IQO^ 155,581 156,620 133 163 85.5 104.1 1904 1906-1910 803,880 843 104.9 1905 157,659 145 92.0 1911 163,891 201 122.6 1901-1905 777,905 725 93.2 1912 164,932 219 132.8 1913 165,073 237 143.6 Source: Annual Reports by the Medical OflBcer of Health for Aberdeen. 615 APPENDIX G Table 37 Mortality from Cancer in the City of Edinburgh 1898-1913 Deaths Rate per Deaths Rate per "iear Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1898 301,305 267 88.6 1906 319,120 330 103.4 1899 305,468 276 90.4 1907 319,464 344 107.7 1900 309,688 297 95.9 1908 319,809 353 110.4 1909 320,282 373 116.5 1901 316,921 293 92.5 1910 320,504 387 120.7 1902 1903 317,880 318,219 312 316 98.2 99.3 1906-1910 1,599,179 1,787 111.7 1904 318,560 331 103.9 1905 318,777 344 107.9 1911 320,829 405 126.2 1912 321,119 400 124.6 1901-1905 1,590,357 1,596 100.4 1913 321,645 401 124.7 Source: Annual Reports of the Public Health Department of the City of Edin- burgh. Table 38 Mortality from Cancer in the City of Edinburgh, Males 1898-1913 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1898 137,696 104 75.5 1906 144,210 132 91.5 1899 139,477 112 80.3 1907 144,110 120 83.3 1900 141,280 116 82.1 1908 144,010 123 85.4 1909 143,967 130 90.3 1901 144,421 110 76.2 1910 143,810 167 116.1 1902 1903 144,635 144,567 127 130 87.8 89.9 1906-1910 720,107 672 93.3 1904 144,499 125 86.5 1905 144,374 124 85.9 1911 143,667 154 107.2 1912 144,118 139 96.4 1901-1905 722,496 616 85.3 1913 144,354 146 101.1 Source: Annual Reports of the Public Health Department of the City of Edin- burgh. 616 APPENDIX G Table 39 Mortality from Cancer in the City of Edinburgh, Females 1898-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1898 163,609 163 99.6 1906 174,910 198 113.2 1899 165,991 164 98.8 1907 175,354 224 127.7 1900 168,408 181 107.5 1908 175,799 230 130.8 1909 176,315 243 137.8 1901 172,500 183 106.1 1910 176,694 220 124.5 1902 173,245 185 106.8 1903 173,652 186 107.1 1906-1910 879,072 1,115 126.8 1904 174,061 206 118.3 1905 174,403 220 126.1 1911 177,162 251 141.7 1912 177,001 261 147.5 1901-1905 867,861 980 112.9 1913 177,291 255 143.8 Source: Annual Reports of the Public Health Department of the City of Edin- burgh. Table 40 Mortality from Cancer in Glasgow 1881-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 511,914 239 46.7 1901 775,594 571 73.6 1882 513,915 252 49.0 1902 776,484 649 83.6 1883 515,924 236 45.7 1903 777,374 624 80.3 1884 517,941 274 52.9 1904 778,264 650 83.5 1885 519,965 266 51.2 49.1 1905 1901-1905 779,154 693 86.9 1881-1885 2,579,659 1,267 3,886,870 3,187 82.0 1886 521,999 270 51.7 1906 780,044 803* 102.9 1887 524,039 275 52.5 1907 780,934 818* 104.7 1888 526,088 287 54.6 1908 781,824 801* 102.5 1889 555,811 337 60.6 1909 782,714 840* 107.3 1890 561,561 314 55.9 55.1 1910 1906-1910 783,605 896* 114.3 1886-1890 2,689,498 1,483 3,909,121 4,158* 106.4 1891 567,272 339 59.8 1911 784,496 809 103.1 1892 669,059 410 61.3 1912 785,600 844 107.4 1893 677,883 437 64.5 1913 1,029,478 971 94.3 1894 686,820 472 68.7 1895 695,876 462 66.4 Source: Annual Reports of the Registrar- General on rifntVio anrl Mar- 1891-1895 3,296,910 2,120 64.3 riages registered in Scotland. 1881-1908, Communications Statistiques 1896 705,052 470 66.7 pubUees par le Bureau Municipal de Statis- 1897 714,919 521 72.9 tique d'Amsterdam, No 33. 1898 724,349 525 72.5 *Deaths of non-residjnts included, 1906-1910. 1899 742,194 612 82.5 1900 753,494 565 75.0 74.0 1896-1900 3,640,008 2,693 617 APPENDIX G Table 41 Mortality from Cancer in Ireland 1881-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 5,145,770 1,909 37.1 1906 4,397,571 3,481 79.2 1882 5,101,018 1,882 36.9 1907 4,388,451 3,338 76.1 1883 5,023,811 1,995 39.7 1908 4,384,664 3,314 75.6 1884 4,974,561 1,947 39.1 1909 4,386,601 3,502 79.8 1885 4,938,588 1,925 39.0 38.4 1910 4,385,421 3,664 83.5 1881-1885 25,183,748 9,658 1906-1910 21,942,708 17,299 78.8 1886 4,905,895 2,029 41.4 1911 4,383,608 3,582 81.7 1887 4,857,119 2,067 42.6 1912 4,384,710 3,734 85.2 1888 4,801,312 2,003 41.7 1889 4,757,385 2,134 44.9 Source : Detailed Annual Reports of the 1890 4,717,959 2,145 45.5 Registrar-General for Ireland on Mar- riages. Births and Deaths. 1886-1890 24,039,670 10,378 43.2 1891 4,680,376 2,163 46.2 1892 4,633,808 2,221 47.9 1893 4,607,462 2,280 49.5 1894 4,589,260 2,375 51.8 1895 4,559,936 2,296 50.4 49.1 1891-1895 23,070,842 11,335 1896 4,542,061 2,437 53.7 1897 4,529,917 2,635 58.2 1898 4,518,478 2,657 58.8 1899 4,502,401 2,654 58.9 1900 4,468,501 2,717 13,100 60.8 58.1 1896-1900 22,561,358 1901 4,447,085 2,893 65.1 1902 4,434,551 2,861 64.5 1903 4,417,757 3,048 69.0 1904 4,408,103 3,055 69.3 1905 4,399,308 3,291 74.8 68.5 1901-1905 22,106,804 15,148 618 APPENDIX G Table 42 Mortality from Cancer in Ireland, Males 1893-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1893 2,268,440 1,052 46.4 1906 2,186,778 1,566 71.6 1894 2,259,919 1,066 47.2 1907 2,183,051 1,530 70.1 1895 2,247,303 995 44.3 1908 2,184,127 1,527 69.9 1909 2,187,792 1,631 74.6 1896 2,239,138 1,100 49.1 1910 2,188,271 1,712 78.2 1897 2,234,205 2,229,701 1,214 1,238 54.3 55.5 1898 1906-1910 10,930,019 7,966 72.9 1899 2,221,965 1,193 53.7 1900 2,204,921 1,212 55.0 1911 1912 2,188,155 2,189,429 1,778 1,768 81.3 1896-1900 11,129,930 5,957 53.5 Source : Detailed Annual Reports of the 1901 2,196,182 1,296 59.0 Registrar-General for Ireland on Mar- 1902 2,193,561 1,286 58.6 riages. Births and Deaths. 1903 2,189,440 1,350 61.7 1904 2,188,276 1,376 62.9 1905 2,186,577 1,443 66.0 61.6 1901-1905 10,954,036 6,751 Table 43 Mortality from Cancer in Ireland, Females 1893-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1893 2,339,022 1,228 52.5 1906 2,210,793 1,915 86.6 1894 2,329,341 1,309 56.2 1907 2,205,400 1,808 82.0 1895 2,312,633 1,301 56.3 1908 2,200,537 1,787 81.2 1909 2,198,809 1,871 85.1 1896 2,302,923 1,337 58.1 1910 2,197,150 1,952 88.8 1897 . 1898 2,295,712 2,288,777 1,421 1,419 61.9 62.0 1906-1910 11,012,689 9,333 84.7 1899 2,280,436 1,461 64.1 1900 2,263,580 1,505 66.5 1911 1912 2,195,453 2,195,281 1,804 1,966 82.2 89.6 1896-1900 11,431,428 7,143 62.5 Source : Detailed Annual Reports of the 1901 2,250,903 1,597 70.9 Registrar- General for Ireland on Mar- 1902 2,240,990 1,575 70.3 riages. Births and Deaths. 1903 2,228,317 1,698 76.2 1904 2,219,827 1,679 75.6 1905 2,212,731 1,848 83.5 75.3 1901-1905 11,152,768 8,397 619 APPENDIX G Table 44 Mortality from Cancer in Ireland, by Provinces and Counties 1901-1910 Deaths Rate per County Population from 100,000 Cancer Population Antrim 1,949,770 1,753 89.9 Belfast Coimty Borough 3,680,630 2,713 73.7 Down 2,050,960 1,912 93.2 Armagh 1,228,420 1,332 108.4 Londonderry 1,425,150 1,382 97.0 Tyrone 1,466,160 1,326 90.4 Monaghan 730,330 603 82.6 Donegal 1,711,290 1,205 70.4 Fermanagh 636,330 456 71.7 Cavan 943,570 584 61.9 Total for Ulster 15,822,610 13,266 83.8 Louth 647,420 598 92.4 Meath 662,940 573 86.4 Dublin 1,649,810 1,576 95.5 Dublin County Borough 2,977,200 3,002 100.8 Kildare 650,970 501 77.0 Wicklow 607,680 497 81.8 Carlow 370,000 296 80.0 Wexford 1,031,880 720 69.8 Kilkenny 770,610 432 56.1 Queens 560,230 375 66.9 Kings 585,090 413 70.6 Westmeath 608,070 446 73.3 Longford 452,470 231 51.1 Total for Leinster 11,574,370 9,660 83.5 Leitrim 664,620 388 58.4 Sligo 815,640 426 52.2 Roscommon 978,730 475 48.5 Mayo 1,956,720 828 42.3 Galway 1,873,870 953 50.9 Total for Connaught 6,289,580 3,070 48.8. Waterford 855,760 645 75.4 Cork 3,983,580 2,743 68.9 Tipperary, S. R 909,850 680 74.7 Tipperary, N. R 653,480 369 56.5 Limerick 1,445,830 861 59.6 Clare 1,082,830 557 51.4 Kerry 1,627,080 596 36.6 Total for Munster 10,558,410 6,451 61.1 Total for Ireland 44,244,970 32.447 73.3 ■ Source: Supplement to the Forty-seventh Report of the Registrar-General of Mar- riages, Births and Deaths in Ireland for the years 1901-1910. 620 APPENDIX G Table 45 Mortality from Cancer in Ireland, by Organs and Parts according to Sex, 1901-1910 Organ or Part Larynx Lungs Mouth Tongue. . . . Pharynx. . . . (Esophagus. Stomach. . . Intestines. . Rectum. . . . Liver and gall-bladder 1,682 Pancreas Glands of neck Kidney and bladder Prostate Male generative organs Ovary Uterus Breast Arm, leg Jaw Face Lips Other organs Ill-defined Not specified MALES Deaths Rate per from 100,000 Cancer Population 158 0.7 70 0.3 156 0.7 733 3.3 494 2.3 456 2.1 4,271 19.5 878 4.0 986 4.5 1,682 7.7 119 0.5 606 2.8 255 1.2 117 0.5 178 0.8 65 0.3 403 1.8 573 2.6 588 2.7 672 3.1 750 3.4 372 1.8 135 0.6 All organs 14,717 67.2 FEIVIALES Deaths Rate per from 100,000 Cancer Population 86 0.4 76 0.3 44 0.2 127 0.6 144 0.6 235 1.1 3,771 17.0 1,026 4.6 744 3.4 2,336 10.5 137 0.6 289 1.3 145 0.7 260 1.2 2,319 10.5 2,957 13.3 545 2.5 204 0.9 482 2.2 122 0.6 833 3.8 708 3.1 140 0.6 17,730 80.0 Source: Supplement to the Forty-seventh Report of the Registrar-General of Mar- riages, Births and Deaths in Ireland, containing Decennial Summaries for the years 1901- 1910. 621 APPENDIX G Table 46 Mortality from Cancer in Ireland, by Age and Sex 1901-1910 MALES Deaths Rate per Ages Population from 100,000 Cancer Population Under 25 10,992,361 237 2.2 25-34 3,153,492 328 10.4 35-44 2,525,420 1,014 40.2 45-54 1,956,435 2,519 128.8 55-64 1,529,695 4,269 279.1 65-74 1,197,058 4,357 364.0 75 and over 529,594 1,993 376.3 All ages 21,884,055 14,717 67.2 FE3*L\LES Under 25 10,761,329 205 1.9 25-34 3,280,488 566 17.3 35-44 : 2,549,028 1,939 76.1 45-54 2,063,604 3,868 187.4 55-64 1,624,728 5,177 318.6 65-74 1,316,628 4,137 314.2 75 and over 569,652 1,838 322.7 All ages 22,165,457 17,730 80.0 Source: Supplement to the Forty-seventh Report of the Registrar-General of Mar- riages, Births and Deaths in Ireland, containing Decennial Summaries for the years 1901-1910. 622 APPENDIX G Table 47 Mortality from Cancer in Ireland, by Organs and Parts and Duration of Illness, Males 1901 Number of Deaths by Duration op Illness 6 Mos. 6 Mos. 1 Year 2 Years Over Total Cases Duration and to to to 3 of Known Not Grand Organ or Part Under 1 Year 2 Years 3 Years Years Duration Given Total Face and nose 10 12 19 5 12 58 9 67 Jaw 9 24 7 2 1 43 5 48 Lips 3 17 20 9 9 58 5 63 Tongue 11 24 8 2 . . 45 3 48 Pharynx and throat . . 13 15 8 . . 2 38 6 44 (Esophagus 9 18 1 .. .. 28 1 29 Stomach 136 120 64 4 3 327 63 390 Rectum 14 28 28 4 2 76 13 89 Other intestines 19 14 11 1 2 47 21 68 Liver and gall-bladder 72 37 16 4 1 130 25 155 Glands of the neck.... 15 29 3 2 . . 49 12 61 Other or not specified organs 58 63 44 12 8 185 49 234 All organs 369 401 229 45 40 1,084 212 1,296 Percentage op Distribution of Cases with Known Duration Face and nose 17.2 20.7 32.8 8.6 20.7 100.0 Jaw 20.9 55.8 16.3 4.7 2.3 100.0 Lips 5.2 29.3 34.5 15.5 15.5 100.0 Tongue 24.5 53.3 17.8 4.4 . . 100.0 Pharynx and throat .. 34.2 39.5 21.0 .. 5.3 100.0 (Esophagus 32.1 64.3 3.6 .. .. 100.0 Stomach 41.6 36.7 19.6 1.2 0.9 100.0 Rectum 18.4 36.8 36.8 5.3 2.7 100.0 Other intestines 40.4 29.8 23.4 2.1 4.3 100.0 Liver and gall-bladder 55.4 28.4 12.3 3.1 0.8 100.0 Glands of the neck.... 30.6 59.2 6.1 4.1 .. 100.0 Other or not specified organs 31.3 34.1 23.8 6.5 4.3 100.0 All organs 34.0 37.0 21.1 4.2 3.7 100.0 Source: Supplement to the Thirty-eighth Detailed Annual Rpenhagen , by Sex, 1894-1912 ' MALES FEMALES Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1894 181,110 185 102.1 1894 213,121 302 141.7 1895 184,821 204 110.4 1895 218,015 309 141.7 1896 188,522 206 109.3 1896 222,919 358 160.6 1897 192,213 226 117.6 1897 227,833 336 147.5 1898 195,894 273 139.4 1898 232,757 353 151.7 1899 199,564 253 126.8 1899 237,692 345 145.1 1900 203,223 262 128.9 124.6 1900 1896-1900 242,638 347 143.0 1896-1900 979,416 1,220 1,163,839 1,739 149.4 1901 206,873 279 134.9 1901 247,593 389 157.1 1902 211,370 285 134.8 1902 253,589 422 166.4 1903 215,855 279 129.3 1903 259,597 421 162.2 1904 220,327 294 133.4 1904 265,618 419 157.7 1905 224,737 321 142.8 135.1 1905 1901-1905 271,701 449 165.3 1901-1905 1,079,162 1,458 1,298,098 2,100 161.8 1906 229,133 347 151.4 1906 277,798 435 156.6 1907 233,513 356 152.5 1907 283,911 497 175.1 1908 237,879 358 150.5 1908 290,038 444 153.1 1909 242,231 360 148.6 1909 296,179 479 161.7 1910 246,567 410 166.3 154.0 1910 1906-1910 302,336 1,450,262 518 171.3 1906-1910 1,189,323 1,831 2,373 163.6 1911 250,870 369 147.1 1911 308,528 514 166.6 1912 255,645 428 167.4 1912 314,355 547 174.0 Source : Dodsaarsag erne i Kongeriget Danmarks Byer. Note: Deaths of rural patients in hos- pitals are excluded. 639 APPENDIX G Table 84 Cancer Census of Iceland, by Organs and Parts according to Sex, 1908 Organ or Part Lips, jaw and tongue. Stomach Intestines Breast Generative organs. . . . Sarcoma MALES Cases of Cancer Rate per 100,000 Population 1 2.5 2 5.0 1 2.5 5.0 15.0 FEMALES Cases of Cancer Rate per 100,000 Population 2 4.7 4 9.3 1 2.3 5 11.7 5 11.7 17 39.7 All organs 6 Source: Zahlung der Krebskranken auf Island. In: Zeitschrif t fiir Krebsforschung, 13. Band. Table 85 Cancer Census of Finland, by Organs and Parts according to Sex, 1909 MALES Cases of Per Organ or Part Cancer Cent. Lips 60 24.6 Tongue and mouth 15 6.1 Oesophagus 10 4.1 Stomach 101 41.4 Liver and gall-bladder 6 2.5 Intestines 10 4.1 Rectum 4 1.6 Kidney...... 3 1.2 Vesica urinaria 4 1.6 Prostata and penis 6 2.5 Breast Uterus Ovaries and generative organs Cancer cutis 16 6.6 Other or not specified organs 9 3.7 All organs 244 100.0 Source: Zeitschrift fiir Krebsforschung, 12. Band. FEMALES Cases of Per Cancer Cent. 10 3.2 5 1.6 5 1.6 116 37.2 4 1.3 6 1.9 8 2.6 2 0.6 1 0.3 60 19.2 56 18.0 10 3.2 15 4.8 14 4.5 312 100.0 640 APPENDIX G Table 86 Cases of Cancer in Finland, by Organs and Parts 1890-1907 All Malignant Carcinoma Tumors Organ or Part Per Cent. Per Cent. Lips 18.9 15.8 Jaw 2.8 3.9 Mouth 3.5 3.3 Bre£^st 10.4 9.0 (Esophagus 2.2 1.8 Stomach 24.2 20.3 Intestines 1.9 1.6 Rectum 3.9 3.3 Liver and pancreas 2.2 1.9 Female generative organs 11.1 10.0 Other or not specified organs 18.9 29.1 All organs 100.0 100.0 All malignant tumors 9,119 cases Carcinoma 7,613 cases Table 87 Comparative Distribution of Carcinoma, by Organs and Parts Sweden and Finland, 1890-1907 Organ or Part Sweden Finland Lips 4.2 18.9 Tongue 1.5 1.6 Breast 12.3 10.4 CEsophagus 3.4 2.2 Stomach 45.3 24.2 Intestines and rectum 8.6 5.8 Liver and pancreas 2.6 2.2 Female generative organs 10.7 11.1 Otheror not specified organs 11.4 23.6 Source: tjber maligne Tumoren in Finland, 1890-1907. G. Renwall, In: Zeitschrift f lir Krebsforschung, 9 Band. 1910. Table 87a Mortality from Cancer in Cities of Finland 1910 Deaths Rate per Population from 100,000 Cancer Population Helsingfors 144,483 95 65.8 Abo 50,215 46 91.6 Tammerfors 45,078 18 39.9 Viborg 27,101 16 59.0 Nikolaistad 20,167 17 .84.3 Uleaborg 19,501 10 51.3 Bjorneborg 16,707 19 113.7 Thirty-one other cities 125,926 88 69.9 All cities 449,178 309 68.8 Source: Lisita Snomen Viralliseen Tilastoon: XI. Laakintolaitos, 1910. Helsinski, 1912. 641 APPENDIX G Table 88 Mortality from Cancer in the German Empire 1891-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 37,483,234 20,043 53.5 1906 60,407,847 49,127 81.3 1892 47,125,446 28,745 61.0 1907 61,259,086 50,930 83.1 1893 47,625,932 30,013 63.0 1908 62,110.325 51,948 63.6 1894 48,259,077 31,137 64.5 1909 62,953,056 53,214 84.5 1895 48,818,672 32,071 65.7 61.9 1910 63,751,143 56,092 88.0 1891-1895 229,312,361 142,009 1906-1910 310,481,457 261,311 84.2 1896 49,356,136 33,620 68.1 1911 64,612,000 57,519 89.0 1897 49,893,600 34,584 69.3 1912 65,450,000 58,937 90.0 1898 50.431,064 35,504 70.4 1899 51,843,158 38,209 73.7 Source: Statistisches Jahrbuch fiir das 1900 52,624,706 37,946 72.1 Deutsche Reich, 1913 Medizinal-sta- tistische Mitteilungen lichen Gesundheitsamte. 1896-1900 254,148,664 179,863 70.8 Annual Report of the Registrar-General of Births Deaths 1901 53,406,252 39,917 74.7 and Marriages in England and Wales, 1910. 1902 54,187,799 40,613 74.9 Note: Includes all kinds of tumors. 1903 54,969,346 42,535 77.4 1891, only for Prussia, B avaria and Baden. 1904 58,433,571 46,723 80.0 1892-1903, only for ten of the states. 1904- 1905 59,413,982 48,078 80.9 1912, for all the Empire , except Mecklen- burg-Schwerin and Mecklenburg-S 1901-1905 280,410,950 217,866 77.7 Table 89 Mortality from Cancer in the German Empire, by Sex 1905-1912 MALES FEMALES Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1905 29,279,210 21,556 73.6 1905 30,134,772 26,522 88.0 1906 29,781,068 21,936 73.7 1906 30,626,779 27,191 88.8 1907 30,212,981 22,806 75.5 1907 31,046,105 28,124 90.6 1908 30,651,445 23,225 75.8 1908 31,458,880 28,723 91.3 1909 31,061,038 23,885 76.9 1909 31,892,018 29,329 92.0 1910 31,461,189 25,001 79.5 76.3 1910 1906-1910 32,289,954 31,091 96.3 1906-1910 153,167,721 116,853 157,313,736 144,458 91.8 1911 31,886,022 25,769 80.8 1911 32,725,978 31,750 97.0 1912 32,312,665 26,442 81.8 1912 33,137,335 32,495 98.1 Source: Medizinal-statistische Mitteil- ungen aus > dem kaiserlichen Gesundheit- samte. Note: [ncludes all kinds of tumors. Does not include Mecklenburg-Schwerin and Mecklenburg-Strelitz. 642 APPENDIX G Table 90 Table 91 Mortality from Cancer and Other Tumors in Bavaria Mortality from Cancer and Other Tumors in Bavaria, Males 1886-1912 Rate per 100,000 Population Year 1886-1912 Year Population Deaths from Cancer Population Deaths from Cancer Rate per 100,000 Population 1886 1887 1888 1889 1890 5,455,155 5,490,111 5,525,068 5,560,025 5,594,982 3,534 3,516 4,375 4,527 4,520 64.8 64.0 79.2 81.4 80.8 74.1 1886 1887 1888 1889 1890 1886-1890 2,656,115 2,674,782 2,693,471 2,712,736 2,731,120 1,492 1,490 1,802 1,877 1,867 56.2 55.7 66.9 69.2 68.4 1886-1890 27,625,341 20,472 13,468,224 8,528 63.3 1891 1892 1893 1894 1895 5,639,694 5,684,406 5,729,118 5,773,831 5,818,544 4,984 4,806 5,126 5,318 5,499 88.4 84.5 89.5 92.1 94.5 89.8 1891 1892 1893 1894 1895 1891-1895 2,754,427 2,777,401 2,800,393 2,823,403 2,846,687 2,049 2,074 2,208 2,340 2,331 74.4 74.7 78.8 82.9 81.9 1891-1895 28,645,593 25,733 14,002,311 11,002 78.6 1896 1897 1898 1899 1900 5,890,046 5,961,548 6,033,051 6,104,554 6,176,057 5,588 5,750 5,845 6,192 6,104 94.9 96.5 96.9 101.4 98.8 97.7 1896 1897 1898 1899 1900 1896-1900 2,883,178 2,919,370 2,955,592 2,991,842 3,028,100 2,426 2,528 2,552 2,625 2,668 84.1 86.6 86.3 87.7 88.1 1896-1900 30,165,256 29,479 14,778,082 12,799 86.6 1901 1902 1903 1904 1905 6,245,720 6,315,383 6,385,046 6,454,709 6,524,372 6,407 6,524 6,859 7,122 7,074 102.6 103.3 107.4 110.3 108.4 106.5 1901 1902 1903 1904 1905 1901-1905 3,062,277 3,095,801 3,129,311 3,162,807 3,196,647 2,692 2,777 2,917 3,068 3,114 87.9 89.7 93.2 97.0 97.4 1901-1905 31,925,230 33,986 15,646,843 14,568 93.1 1906 1907 1908 1909 1910 6,596,955 6,669,539 6,742,123 6,814,707 6,887,291 7,258 7,104 7,274 7,472 7,820 110.0 106.5 107.9 109.6 113.5 109.5 1906 1907 1908 1909 1910 1906-1910 3,233,168 3,269,408 3,305,663 3,342,614 3,379,580 3,137 3,075 3,149 3,253 3,432 16,046 97.0 94.1 95.3 97.3 101.6 1906-1910 33,710,615 36,928 16,530,433 97.1 1911 1912 6,959,875 7,032,459 7,828 8,095 112.5 115.1 1911 1912 3,415,907 3,452,234 3,426 3,538 100.3 102.5 Source: Statistisches Jahrbuch fiir das Konigreich Bayern. Source: Statistisches Jahrbuch fiir das Konigreich Bayern. APPENDIX G Table 92 Mortality from Cancer and Other Tumors in Bavaria, Females 1886-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1886 2,799,040 2,042 73.0 1901 3,183,443 3,715 116.7 1887 2,815,329 2,026 72.0 1902 3,219,582 3,747 116.4 1888 2,831,597 2,573 90.9 1903 3,255,735 3,942 121.1 1889 2,847,289 2,650 93.1 1904 3,291,902 4,054 123.2 1890 .2,863,862 2,653 92.6 84.4 1905 1901-1905 3,327,725 3,960 119.0 1886-1890 14,157,117 11,944 16,278,387 19,418 119.3 1891 2,885,267 2,935 101.7 1906 3,363,787 4,121 122.5 1892 2,907,005 2,732 94.0 1907 3,400,131 4,029 118.5 1893 2,928,725 2,918 99.6 1908 3,436,460 4,125 120.0 189-t 2,950,428 2,978 100.9 1909 3,472,093 4,219 121.5 1895 2,971,857 3,168 106.6 100.6 1910 1906-1910 3,507,711 4,388 125.1 1891-1895 14,643,282 14,731 17,180,182 20,882 121.5 1896 3,006,868 3,162 105.2 1911 3,543,968 4,402 124.2 1897 3,042,178 3,222 105.9 1912 3,580,225 4,557 127.3 1898 3,077,459 3,293 107.0 1899 3,112,712 3,567 114.6 Source: Statistisches Jahrbuch fiir das 1900 3,147,957 3,436 109.2 108.4 Konigreich Bayern. 1896-1900 15,387,174 16,680 Table 93 Mortality from Cancer in Bavaria, by Geographical Divisions Rate per 100,000 of Population, Males 1905-1907 Stomach Liver and Pancreas Oberbayern 63.6 Niederbayern 55.0 Schwaben 90.0 Oberpfalz 68.2 Mittelf ranken 56.2 Pfalz 47.2 Oberf ranken 59.7 Unterf ranken 56.7 All Bavaria 61.8 ntestines and All Organ Rectum 15.4 104.4 7.6 82.9 15.1 135.1 9.8 96.0 12.2 94.4 6.0 76.6 7.4 82.6 9.3 93.5 10.9 96.6 Source: K. Kolb: Die Lokalisation des Krebses in den Organen in Bayern. In: Zeitschrift fiir Krebsforschung, 8. Band. 644 APPENDIX G Table 94 Mortality from Cancer in Bavaria, by Geographical Divisions Rate per 100,000 of Population, Females 1905-1907 Stomach Liver and Pancreas Oberbayern 59.2 Niederbayern 48.2 Schwaben 76.0 Oberpfalz 50.0 Mittelfranken 53.1 Pfalz 56.3 Oberfranken 48.6 Unterfranken 58.1 AllBavaria 56.7 Intestines and Rectum Uterus Breast All Organ 11.3 34.4 11.9 138.5 6.8 26.3 9.9 112.5 12.7 28.5 13.0 155.2 8.5 15.7 9.0 101.6 9.3 24.8 9.0 119.4 6.5 12.2 4.9 101.8 8.1 13.6 7.3 . 91.9 7.9 15.1 8.7 110.8 9.1 22.7 9.4 119.3 Source: K. Kolb: Die Lokalisation des Krebses in den Organen in Bayern. In: Zeitschrift fiir Krebsforschung, 8. Band. Table 95 , Mortality from Cancer in Bavaria, by Organs and Parts, according to Sex 1905-1910 Organ or Part Lips and mouth CEsophagus, stomach and liver 12,373 Intestines Rectum Gall-bladder Pancreas - Peritoneum Larynx Lungs and pleura Kidneys Bladder Prostata Uterus Ovaries Vagina Breast Brain Skin Head and extremities Other organs Not specified M. i.LES FEIHALES Deaths Rate per Deaths Rate per from 100,000 from 100,000 Cancer Population Cancer Population 335 1.7 140 0.7 12,373 62.9 11,291 55.0 1,090 5.5 1,222 6.0 1,068 5.4 709 3.5 66 0.3 181 0.9 108 0.5 98 0.5 371 1.9 1,079 5.3 183 0.9 45 0.2 163 0.8 140 0.7 162 0.8 109 0.5 605 3.1 187 0.9 204 1.0 o • 3,933 19.2 396 1.9 105 0.5 13 0.1 1,871 9.1 158 0.8 168 0.8 124 0.6 187 0.9 659 3.3 716 3.5 223 1.1 319 1.6 347 1.8 502 2.4 All organs 18,252 92.5 23,398 114.1 Source: Bericht tiber das Bayerlsche Gesundheitswesen. Miinchen, 1912. 64c APPENDIX G Table 95a Mortality from Cancer in Bavaria, by Age 1901-1912 Rate peb 100,000 of Population Age 1901-1910 1910 1911 1912 Under 1 6.0 3.9 3.9 2.2 1-4 3.3 4.1 3.3 3.0 5-14 2.0 1.8 1.8 1.4 15-19 3.6 2.5 2.6 2.8 20-29 8.1 6.9 7.4 8.7 a}-39 39.9 39.9 37.0 42.3 40-49 139.5 136.7 142.0 153.1 50-59 334.1 360.5 349.4 351.4 60-69 647.4 681.6 670.5 683.5 70-79 808.5 917.8 948.8 936.2 80 and over 663.9 745.2 724.3 777.6 All ages 108.0 113.5 112.5 115.1 Source: Bericht iiber das Bayerische Gesundheitswesen, 39. Band, die Jahre, 1911 und 1912, umfassend. Table 96 Mortality from Cancer in Prussia 1881-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 27,400,370 8,525 31.1 1901 34,801,604 21,488 61.7 1882 27,608,242 8,778 31.8 1902 35,365,767 21,876 61.9 1883 27,816,114 9,383 33.7 1903 35,929,930 23,420 65.2 1884 28,023,986 9,865 35.2 1904 36,494,093 25,050 68.6 1885 28,231,858 10,108 35.8 33.5 1905 1901-1905 37,058,256 25,704 694 1881-1885 139,080,570 46,659 179,649,650 117,538 654 1886 28,509,431 10,919 38.3 1906 37,628,378 26,498 70.4 1887 28,836,793 10,981 38.1 1907 38,202,757 28,034 73.4 1888 29,164,155 11,906 40.8 1908 38,777,136 28,531 73.6 1889 29,491,517 12,819 43.5 1909 39,351,515 29,429 74.8 1890 29,818,879 12,904 43.3 40.8 1910 1906-1910 39,925,894 31,340 78.5 1886-1890 145,820,775 59,529 193,885,680 143,832 74.2 1891 30,176,929 13,487 44.7 1911 40,500,273 32,660 80.6 1892 30,556,897 15,122 49.5 1912 41,074,652 33,463 81.5 1893 30,936,865 15,740 50.8 1894 31,316,833 16,480 52.6 Source: Tables 96-98 Annual Reports of 1895 31,696,801 16,850 53.2 the Regist rar-General of Births, Deaths and 50.2 Marriages in England and W ales Statistisches Jahrbuch fiir den 1891-1895 154,084,325 77,679 Preussi- schen Staat. 1896 32,160,485 17,643 54.9 Das Gesundheitswesen des Preussischen 1897 32,GS3,!}G2 18,315 56.0 Staat. 1898 33,207,439 18,695 56.3 Note: Includes all tumors. 1899 33,730,916 20,011 59.3 1900 34,254,393 20,430 59.6 57.3 1896-1900 166,037,195 95,094 646 APPENDIX G Table 97 Table 98 Mortality from Cancer in Prussia Mortality from Cancer in Prussia Males, 1898 -1912 Deaths Rate per Females, 1898-1912 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1898 16,334,739 8,595 52.6 1898 16,872,700 10,100 59.9 1899 16,598,984 9,055 54.6 1899 17,131,932 10,956 64.0 1900 16,863,438 9,418 55.8 1900 17,390,955 11,012 63.3 1901 17,143,270 9,776 57.0 1901 17,658,334 11,712 66.3 1902 17,428,250 10,011 57.4 1902 17,937,517 11,865 66.1 1903 17,713,455 10,627 60.0 1903 18,216,475 12,793 70.2 1904 17,998,887 11,454 63.6 1904 18,495,206 13,596 73.5 1905 18,284,544 11,609 63.5 60.4 1905 1901-1905 18,773,712 14,095 75.1 1901-1905 88,568,406 53,477 91,081,244 64,061 70.3 1906 18,573,367 11,972 64.5 1906 19,055,011 14,526 76.2 1907 18,864,521 12,726 67.5 1907 19,338,236 15,308 79.2 1908 19,155,905 12,874 67.2 1908 19,621,231 15,657 79.8 1909 19,443,584 13,386 68.8 1909 19,907,931 16,043 80.6 1910 19,731,377 14,155 71.7 68.0 1910 1906-191C 20,194,517 17,185 85.1 1906-1910 95,768,754 65,113 98,116,926 78,719 80.2 1911 20,023,335 14,754 73.7 1911 20,476,938 17,906 87.4 1912 20,315,293 15,142 74.5 1912 20,759,359 18,321 88.3 Table 98a Mortality from Cancer in Prussia, by Age and Sex Rate per 100,000 of Population 1903-1913 TOTAL MALES FEMALES Year Ages Under 30 Ages 30-59 Ages 60 and Over Ages Under 30 Ages 30-59 Ages 60 and Over Ages Under 30 Ages 30-59 Ages 60 and Over 1903... . 1.4 92.0 404.7 1.1 81.7 431.9 1.8 101.8 328.6 1904... . 1.6 95.4 427.2 1.3 86.1 458.5 2.0 104.2 401.7 1905 . . . . 1.5 93.6 439.5 1.2 82.8 464.0 1.7 103.9 419.6 1906... . 1.6 94.5 446.6 1.2 82.9 474.1 1.9 105.7 424.5 1907... . 1.5 97.4 464.6 1.3 85.6 493.6 1.6 108.7 441.3 1908... . 1.4 98.5 464.9 1.0 87.0 491.0 1.8 109.6 444.0 1909... . 1.6 99.1 476.6 1.4 87.8 507.0 1.7 109.8 452.3 1910... . 1.5 103.7 502.8 1.2 90.7 534.1 1.8 116.2 477.8 1911... . 1.5 101.6 524.9 1.4 89.5 552.6 1.7 113.2 503.0 1912... . 1.5 100.0 535.9 1.3 86.6 574.0 1.6 112.8 505.7 1913... . 1.6 101.3 541.6 1.4 86.6 576.9 1.7 115.5 513.8 Source: Statistisches Jahrbuch fiir den Preussischen Staat, 1914. Note: Includes only carcinoma. 647 APPENDIX G Table 99 Table 100 Mortality from Cancer in Wiirttem- Mortality from Cancer in Baden berg, by Sex 1904-1912 1881-1912 Deaths Rate per Year Population from 100,000 TOTAL Cancer Population Year Population Deaths from Rate per 100,000 1881 1882 1,573,873 1,580,073 1,189 1,263 75.5 79.9 Cancer Population 1883 1,586,273 1,238 78.0 1904 2,275,100 1,967 86.5 1884 1,592,473 1,240 77.9 1905 2,302,179 2,329,258 2,124 2,053 92.3 88.1 1885 1881-1885 1,598,673 1,322 82.7 1906 7,931,365 6,252 78.8 1907 1908 1909 1910 2,356,337 2,383,416 2,410,495 2,437,574 2,162 2,215 2,307 2,344 91.8 92.9 95.7 96.2 93.0 92.9 1886 1887 1888 1889 1890 1886-1890 1,607,863 1,619,108 1,630,421 1,641,825 1,653,307 1,454 1,363 1,412 1,480 1,532 90.4 84.2 86.6 90.1 1906-1910 11,917,080 2,464,700 11,081 2,289 92.7 1911 8,152,524 7,241 88.8 1912 2,491,826 2,511 100.8 1891 1,666,611 1,572 94.3 1892 1,680,022 1,504 89.5 MALES 1893 1,693,540 1,643 97.0 1904 1,109,339 853 76.9 1894 1,707,158 1,636 95.8 1905 1,122,914 1,136,911 958 924 85.3 81.3 1895 1891-1895 1,720,904 1,719 99.9 1906 8,468,235 8,074 95.3 1907 1908 1,150,835 1,164,775 961 963 83.5 82.7 1896 1,748,500 1,824 104.3 1909 1,178,732 1,005 85.3 1897 1,776,539 1,750 98.5 1910 1,192,392 1,013 85.0 1898 1,805,026 1,841 102.0 83.6 86.1 1899 1900 1896-1900 1,833,988 1,863,384 1,858 1,882 101.3 1906-1910 5,823,645 1,205,731 4,866 1,038 101.0 1911 9,027,437 9,155 101.4 1912 1,219,070 1,105 90.6 1901 1,890,934 2,055 108.7 T?T?A T A T "L ^ 1902 1,918,890 2,097 109.3 1 tMALbo 1903 1,947,258 2,088 107.2 1904 1,165,761 1,114 95.6 1904 1,976,044 2,235 113.1 1905 1,179,265 1,192,347 1,166 1,129 98.9 94.7 1905 1901-1905 2,006,168 2,205 109.9 1906 9,739,294 10,680 109.7 1907 1,205,502 1,201 99.6 1908 1,218,641 1,252 102.7 1906 2,031,921 2,125 104.6 1909 1,231,763 1,302 105.7 1907 2,058,004 2,101 102.1 1910 1,245,182 1,331 106.9 1908 2,084,421 2,225 106.7 102.0 99.4 1909 1910 1906-1910 2,111,176 2,138,273 2,343 2,428 111.0 1906-1910 6,093,435 1,258,969 6,215 1,251 113.5 1911 10,423,795 11,222 107.7 1912 1,272,756 1,406 110.5 1911 2,164,694 2,419 111.7 1912 2,191,115 2,452 111.9 Source: Statistisch es Handbuch fur das Konigreich Wurttemberg. Source: Die Statistik des Bewegung der Note: ] ncludes only carcinoma. Bevolkerung sowie die medizinische und ge- burtshiifliche Statistik. Statistische Mit- teilungen liber das Groszherzogtum Baden. Note: The data for 1905 and later years include only carcinoma 648 APPENDIX G Table 101 Mortality from Cancer in Baden, by Sex 1905-1912 MALES FEMALES Year 1905 Population 993,454 Deaths from Cancer 979 Rate per 100,000 Population 98.5 Year 1905 Population 1,012,714 Deaths from Cancer 1,226 Rate per 100,000 Population 121.1 1906 1907 1908 1909 1910 1,006,004 1,018,506 1,031,372 1,044,399 1,057,376 947 989 986 1,049 1,121 94.1 97.1 95.6 100.4 106.0 98.7 1906 1907 1908 1909 1910 1906-1910 1,025,917 1,039,498 1,053,049 1,066,777 1,080,897 1,178 1,112 1,239 1,294 1,307 114.8 107.0 117.7 121.3 120.9 1906-1910 5,157,657 5,092 5,266,138 6,130 116.4 1911 1912 1,070,225 1,083,074 1,167 1,083 109.0 100.0 1911 1912 1,094,469 1,108,041 1,252 1,369 114.4 123.6 Source: Die Statistik des Bewegung der Bevolkerung sowie die medizinische und gebiirtshilfliche Statistik. Statistische Mitteilungen iiber das Groszherzogtum Baden. Note: Includes only carcinoma. Table 102 Mortality from Cancer in the Kingdom of Saxony, by Sex 1904-1912 TOTAL FEMALES Year 1904 1905 Population 4,416,686 4,478,963 Deaths from Cancer 3,533 3,701 Rate per 100,000 Population 80.0 82.6 Year 1904 1905 Population 2,279,893 2,314,280 Deaths from Cancer 1,961 2,013 Rate per 100,000 Population 86.0 87.0 1906 1907 1908 1909 1910 4,551,500 4,622,400 4,690,700 4,749,900 4,778,000 3,843 4,012 3,916 3,948 3,994 84.4 86.8 83.5 83.1 83.6 84.3 1906 1907 1908 1909 1910 1906-1910 2,351,760 2,387,932 2,423,216 2,453,323 2,467,837 2,125 2,261 2,171 2,167 2,227 90.4 94.7 89.6 88.3 90.2 1906-1910 23,392,500 19,713 12,084,068 10,951 90.6 1911 1912 4,810,000 4,840,000 4,172 4,200 86.7 86.8 1911 1912 2,484,365 2,499,860 2,303 2,280 92.7 91.2 1904 1905 MALES 2,136,793 2,164,683 1,572 1,688 73.6 78.0 Source: Statistisches Jahrbuch fiir das Konigreich Sachsen. Note: Includes only carcinoma. 1906 1907 1908 1909 1910 2,199,740 2,234,468 2,267,484 2,296,577 2,310,163 1,718 1,751 1,745 1,781 1,767 78.1 78.4 77.0 77.6 76.5 77.5 1906-1910 11,308,432 8,762 1911 1912 2,325,635 2,340,140 1,869 1,920 80.4 82.0 649 APPENDIX G Table 103 Table 104 Mortality from Cancer in Alsace- Mortality from Cancer in Heligoland Lorraine, 19 05-1912 Deaths Rate per 1840-1903 D Year Population from Cancer 100,000 Population Years Population from Cancer 100,000 Population 1905 1,807,200 1,498 82.9 1840-1850 18,000 6 33.3 1851-1860 17,400 2 11.5 1906 1,822,000 1,414 77.6 1861-1870 18,500 1 5.4 1907 1,834,100 1,477 80.5 1871-1880 19,700 14 71.1 1908 1,845,500 1,543 83.6 1881-1890 21,000 U 71.4 1909 1,856,600 1,496 80.6 1891-1900 22,300 13 58.3 1910 1,868,900 1,516 81.1 80.7 1901-1903 1840-1903 7,100 10 61 140.8 1906-1910 9,227,100 7,446 124,000 49.2 1911 1,875,900 1,546 82.4 Source : I/indemann: tJber Krebs- 1912 1,883,000 1,551 82.4 statistik auf Helgoland. In : Zeitschrift f iir Krebsforschune. 1. Band. Source: Statistisches Jakrbuch ftir Elsass-Lothringen . Note: Includes only carcinoma. Table 103a Mortality from Cancer and Other Tumors, by Age and Sex, according to Religious Confession, in the Grand-Duchy of Hesse, 1901-1912 NuMBEB OP Deaths from Cancer Christians (1906-1910) Ages Under 1 1-14 15-29 30-59 60-69 70 and over . Males Females All ages 2,689 Ages Under 1 .... , 1-14 15-29 30-59 60-69 70 and over . 35 31 47 60 962 1,471 975 1,189 668 796 2,689 3,553 Rate per 10 Christians (1906-1910) Males Females 2 7 4 3 6 8 101 149 651 686 877 893 Jews (1901-1912) Males i 1 43 63 60 168 Females 6 102 74 85 267 All ages. 116 Jews (1901-1912) Males 611 1,044 119 Females 16 177 634 1,342 177 Source: Die gegenwartige Sterblichkeit der jiidischen und christlichen Bevol- kerung des Groszherzogtums Hessen nach Geschlecht, Alter und Todesursachen. Von Regierungsrat Knopfel, Darmstadt. 050 APPENDIX G Table 105 Mortality from Cancer in Heligoland, by Organs and Parts according to Sex, 1840-1903 Absolute Figdres Per Cent. OF Total Organ or Part Males Females Males Females Lips 3 15.7 Tongue 2 4.8 Throat 1 5.3 Stomach 13 18 68.4 42.8 Liver 1 2 2 5.3 4.8 Peritoneum 4.8 Intestines 1 5.3 Breast 8 19.6 Uterus 5 11.9 Not specified 19 5 42 11.9 All organs 100.0 100.0 Source: Lindemann: tJber Krebsstatistik auf Helgoland. In: Zeitschrift fiir Krebsforschung, 1. Band. Table 106 Mortality from Cancer in Hamburg, by Sex 1900-1912 TOTAL MALES Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1900 761,130 769 101.0 1907 456,745 442 96.8 1908 469,165 488 104.0 1901 780,190 773 99.1 1909 481,421 462 96.0 1902 797,850 805 100.9 1910 497,799 475 95.4 1903 814,290 878 107.8 1904 834,996 908 108.7 1911 512,942 443 86.4 1905 862,443 945 109.6 105.4 1912 529,899 470 FEMALES 88.7 1901-1905 4,089.769 4,309 1907 463,369 528 113.9 1906 889,951 898 100.9 1908 475,209 550 115.7 1907 920,114 970 105.4 1909 486,844 546 112.2 1908 944,374 1,038 109.9 1910 502,601 607 120.8 1909 968,265 1,008 104.1 1910 1,000,400 1,082 108.2 1911 517,062 604 116.8 1912 533,302 631 118.3 1906-1910 4,723,104 4,996 105.8 Source: Bericht iiber die Medizinische 1911 1,030,004 1,047 101.7 Statistik des Hamburgischen Staates. 1912 1,063,201 1,101 103.6 651 APPENDIX G Table 107 Mortality from Cancer in Bremen 1896-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1896 195,042 196 100.5 1906 263,323 249 94.6 1897 200,609 190 94.7 1907 271,374 300 110.5 1898 206,176 176 85.4 1908 279,425 302 108.1 1899 211,723 197 93.0 1909 287,476 300 104.4 1900 217,315 199 91.6 92.9 1910 1906-1910 295,527 311 105.2 1896-1900 1,030,865 958 1,397,125 1,462 104.6 1901 225,240 191 84.8 1911 305,724 298 97.5 1902 231,427 214 92.5 1912 316,000 335 106.0 1903 238,896 268 112.2 1913 326,000 320 98.2 1904 244,733 227 92.8 1905 255,272 258 101.1 Source : Jahrbuch fur Bremische Sta- tistik. Note: 1901-1905 1,195,568 1,158 96.9 Includes all kinds of t umors Table 108 Mortality from Cancer in Bremen, by Sex 1896-1911 MALES FEiLAXES Deaths Rate per Deaths Rate per Year Population from 100,000 Year . Population from 100,000 Cancer Population Cancer Population 1896 97,404 81 83.2 1896 97,638 115 117.8 1897 100,184 81 80.9 1897 100,425 109 108.5 1898 102,964 64 62.2 1898 103,212 112 108.5 1899 105,734 87 82.3 1899 105,989 110 103.8 1900 108,527 83 76.5 76.9 1900 1896-1900 108,788 116 106.6 1896-1900 514,813 396 516,052 562 108.9 1901 112,485 81 72.0 1901 112,755 110 97.6 1902 115,575 103 89.1 1902 115,852 111 95.8 1903 119,305 107 89.7 1903 119,591 161 134.6 1904 122,220 111 90.8 1904 122,513 116 94.7 1905 127,483 118 92.6 87.1 1905 1901-1905 127,789 140 109.6 1901-1905 597,068 520 598,500 638 106.0 1906 131,504 103 78.3 1906 131,819 146 110.8 1907 135,307 125 92.4 1907 136,067 175 128.6 1908 139,070 125 89.9 1908 140,355 177 126.1 1909 142,818 135 94.5 1909 144,658 165 114.1 1910 146,552 129 88.0 88.7 1910 1906-1910 148,975 182 122.2 1906-1910 695,251 617 701,874 845 120.4 1911 150,756 121 80.3 1911 154,968 177 114.2 Source: Jahrbuch flir Bremische Sta- tistik. Note: Includes all kinds of tumors. 652 APPENDIX G Table 109 Table 110 Mortality from Cancer in Berlin Mortality from Cancer in Berlin 1881-19 12 Deaths from Cancer Rate per 100,000 Population Year Males, 1881 Population -1912 Deaths from Cancer Year Population Rate per 100,000 Population 1881 1882 1883 1884 1885 1,158,559 1,196,205 1,232,716 1,271,677 1,315,665 749 811 845 965 915 64.6 67.8 68.5 75.9 69.5 69.4 1881 1882 1883 1884 1885 1881-1885 557,810 574,735 591,792 609,774 630,859 304 274 290 375 338 54.5 47.7 49.0 61 5 53.6 1881-1885 6,174,822 4,285 2,964,970 1,.581 53.3 188G 1887 1888 1889 1890 1,363,220 1,414,969 1,471,972 1,528,681 1,578,516 1,034 1,059 1,160 1,279 1,222 75.8 74.8 78.8 83.7 77.4 78.2 1886 1887 1888 1889 1890 1886-1890 6.54,598 680,269 707,164 734,925 757,963 367 367 443 485 467 56.1 53.9 62.6 66.0 61.6 1886-1890 7,357,358 5,754 3,534,919 2,129 60.2 1891 1892 1893 1894 1895 1,606,617 1,622,477 1,640,994 1,656,074 1,678,924 1,303 1,335 1,411 1,526 1,622 81.1 82.3 86.0 92.1 96.6 87.7 1891 1892 1893 1894 1895 1891-1895 768,643 772,777 781,069 786,093 797,868 521 534 548 599 671 67.8 69.1 70.2 76.2 84.1 1891-1895 8,205,086 7,197 3,906,450 2,873 73.5 1896 1897 1898 1899 1900 1,721,855 1,756,398 1,803,211 1,846,217 1,888,313 1,765 1,704 1,822 1,971 2,119 102.5 97.0 101.0 106.8 112.2 104.0 1896 1897 1898 1899 1900 1896-1900 817,980 831,768 855,572 878,389 901,847 716 690 761 806 891 87.5 83.0 88.9 91.8 98.8 1896-1900 9,015,994 9,381 4,285,556 3,864 90.2 1901 1902 1903 1904 1905 1,893,941 1,911,628 1,946,076 1,988,742 2,042,402 2,180 2,170 2,271 2,4Y9 2,557 115.1 113.5 116.7 124.7 125.2 119.2 1901 1902 1903 1904 1905 1901-1905 899,710 907,477 927,687 953,119 985,093 943 887 935 1,001 1,066 104.8 97.7 100.8 105.0 108.2 1901-1905 9,782,789 11,657 4,673,086 4,832 103.4 1906 1907 1908 1909 1910 2,073,521 2,076,437 2,057,274 2,057,610 2,071,907 2,648 2,693 2,639 2,782 2,751 127.7 129.7 128.3 135.2 132.8 130.7 1906 1907 1908 1909 1910 1906-1910 1,002,518 999,919 985,355 985,615 994,297 1,081 1,110 1,085 1,174 1,154 107.8 111.0 110.1 119.1 116.1 1906-1910 10,336,749 13,513 4,967,704 5,604 112.8 1911 1912 2,084,045 2,100,000 2,870 2,789 137.7 132.8 1911 1912 1,001,229 1,005,000 1,165 1,148 116.4 114.2 Source: Statistisch Stadt Berlin. Tabellen 2S Jahrbuch der uber die Bevol- Source: Statistisches Jahrbuch der Stadt Berlin. Tabellen iiber die Bevol- kerungsvorgange Berlins. Note: Includes all kinds of tumors. kerungsvorgange Berlins. Note: Includes all kinds of tumors. 653 APPENDIX G Table 111 Table 112 Mortality from Cancer in Berlin Mortality from Cancer in Females, 1881-1912 Frankfurt a/M. 1891-19i.^ Deaths Rate per Year Population from 100,000 Cancer Population Deaths Rate per 1881 1882 600,749 621,470 445 537 74.1 86.4 Year Population from Cancer 100,000 Population 1883 640,924 555 86.6 1891 185,000 193 104.3 1884 661,903 590 89.1 1892 189,000 180 95.2 1885 684,806 577 84.3 1893 193,300 190 98.3 84.2 94.1 1894 1895 1891-1895 199,600 226,400 182 193 91.2 1881-1885 3,209,852 708,622 2,704 667 85.2 1886 993,300 938 94.4 1887 734,700 692 94.2 1888 764,808 717 93.7 1896 233,500 211 90.4 1889 793,756 794 100.0 1897 240,500 209 86.9 1890 820,553 755 92.0 1898 247,400 249 100.6 1899 257,400 256 99.5 1886-1890 3,822,439 837,974 3,625 782 94.8 93.3 1900 1896-1900 285,000 228 80.0 1891 - 1,263,800 1,153 91.2 1892 849,700 801 94.3 1893 859,925 863 100.4 1901 294,000 254 86.4 1894 869,981 927 106.6 1902 302,000 270 89.4 1895 881,056 951 107.9 1903 310,000 334 107.7 1904 320,000 330,000 307 95.9 1891-1895 4,298,636 903,875 4,324 1,049 100.6 116.1 1905 1901-1905 316 95!8 1896 1,556,000 1,481 95.2 1897 924,630 1,014 109.7 1898 947,639 1,061 112.0 1906 340,000 322 94.7 1899 967,828 1,165 120.4 1907 349,000 337 96.6 1900 986,466 1,228 124.5 1908 358,000 357 99.7 1909 367,000 350 95.4 1896-1900 4,730,438 994,231 5,517 1,237 116.6 124.4 1910 1906-1910 410,000 388 94.6 1901 1,824,000 1,754 96.2 1902 1,004,151 1,283 127.8 1903 1,018,389 1,336 131.2 1911 419,000 403 96.2 1904 1,035,623 1,478 142.7 1912 428,500 352 82.1 1905 1,057,309 1,491 141.0 133.6 1913 Source: 438,000 Tabellarische 403 tJbersic 92.0 1901-1905 5,109,703 6,825 hten be- treffend den Zivilstand der Stadt Frank- 1906 1,071,003 1,567 146.3 furt am "M ain. 1907 1,076,518 1,583 147.0 Note: ncludes only carcinoma. 1908 1,071,919 1,554 145.0 1909 1,071,995 1,608 150.0 1910 1,077,610 1,597 148.2 147.3 1906-1910 5,369,045 7,909 1911 1,082,816 1,705 157.4 1912 1.095,000 1,641 149.9 Source: Statistisches Jahrbuch der Stadt Berl in. Tabellen liber die Bevbl- kerungsvorgange Berlins. Note: Includes all kinds of tumors. 654 APPENDIX G Table 113 Mortality from Cancer in Frankfurt a/M. 1892-1913 Males Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1892 89,643 50 55.8 1906 165,138 131 79.3 1893 91,663 68 74.2 1907 169,474 133 78.5 1894 94,630 75 79.3 1908 173,809 159 91.5 1895 107,314 84 78.3 1909 178,142 134 75.2 1910 198,932 158 79.4 1892-1895 383,250 277 72.3 1906-1910 885,495 715 80.7 1896 111,123 78 70.2 1897 114,911 84 73.1 1911 203,257 161 79.2 1898 118,678 100 84.3 1912 207,823 153 73.6 1899 123,938 99 79.9 1913 212,000 161 75.9 1900 137,741 98 71.1 Source: Tabellarische treffend den Zivilstand TT1 " 1,^4. r 1896-1900 606,391 459 75.7 der Sta dt Frank- flirt am Main. 1901 142,237 93 65.4 Note: Includes only carcinoma. 1902 146,259 126 86.1 1903 150,288 145 96.5 1904 155,296 122 78.6 1905 160,314 117 73.0 79.9 1901-1905 754,394 603 Table 114 Mortality from Cancer in Frankfurt a/M., Females 1892-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1892 99,357 130 130.8 1906 174,862 191 109.2 1893 101,637 122 120.0 1907 179,526 204 113.6 1894 104,970 107 101.9 1908 184,191 198 107.5 1895 119,086 109 91.5 1909 188,858 216 114.4 1910 211,068 230 109.0 1892-1895 425,050 468 110.1 1906-1910 938,505 1,039 110.7 1896 122,377 133 108.7 1897 125,589 125 99.5 1911 215,743 242 112.2 1898 128,-722 149 115.8 1912 220,677 199 90.2 1899 133,462 157 117.6 1913 226,000 242 107.1 1900 147,259 130 88.3 Source: Tabellarische treffend den Zivilstand TTl • "1 4. 1 1896-1900 657,409 694 105.6 der Sta dt Frank- furt am Main. 1901 151,763 161 106.1 Note: Includes only carcinoma. 1902 155,741 144 92.5 1903 159,712 189 118.3 1904 164,704 185 112.3 1905 169,686 199 117.3 109.5 1901-1905 801,606 878 655 APPENDIX G Table 115 Mortality from Cancer in Frankfurt a/M., by Organs and Parts according to Sex, 1906-1912 MALES Organ or Part Skin Digestive organs . . . Respiratory organs. Urinary organs . . . . Generative organs. . Other organs Sarcoma Other organs Deaths Rate per from 100,000 Cancer Population 7 0.5 869 67.0 50 3.9 41 3.2 14 1.1 48 3.7 52 4.0 55 4.2 FEMALES Deaths Rate per from 100,000 Cancer Population 18 1.3 817 59.4 38 2.8 18 1.3 456 33.2 133 9.7 51 3.7 61 4.4 Allorgans 1,136 87.6 1.592 Source: Jahresbericht des Aerztlichen Vereins zu Frankfurt am Main. 115.8 Table 116 Mortality from Cancer in Colonge 1891-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 286,336 237 82.8 1906 438,963 410 93.4 1892 294,313 256 87.0 1907 456,524 426 93.3 1893 302,290 255 84.4 1908 474,085 411 86.7 1894 310,267 261 84.1 1909 491,646 441 89.7 1895 318,244 301 94.6 86.7 1910 1906-1910 509,207 474 93.1 1891-1895 1,511,450 1,310 2,370,425 2,162 91.2 1896 327,507 310 94.7 1911 526,768 525 99.7 1897 337,700 298 88.2 1912 544,329 553 101.6 1898 347,893 282 81.1 1899 358,086 340 94.9 Source : Naturwissenschaft und Gesund- 1900 368,279 312 84.7 heitswesen in Coin. 'Festschrift) 1908. 1909-1912, original data furnished by the Statistical Office of Coin. 1896-1900 1,739,465 1,542 88.6 1901 379,081 356 93.9 1902 390,320 344 88.1 1903 401,559 370 92.1 1904 412,798 379 91.8 1905 424,037 394 92.9 91.8 1901-1905 2,007,795 1,843 656 APPENDIX G Table 117 Mortality from Cancer in Essen a/R., by Sex 1906-1912 TOTAL Year Population Deaths from Cancer Rate per 100,000 Population 1906 1907 1908 1909 1910 238,590 242,137 255,423 266,617 289,309 141 158 162 168 161 60.4 65.3 63.4 63.0 55.6 06-1910 1,287,076 790 61.4 1911 1912 298,079 305,024 185 180 62.1 59.0 MALES FEMALES Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1908 131,926 59 44.7 1908 123,497 103 83.4 1909 137,654 63 45.8 1909 128,963 105 81.4 1910 149,341 68 45.5 1910 139,968 93 66.4 1911 153,839 81 52.7 1911 144,240 104 72.1 1912 157,392 84 53.4 48.6 1912 1908-1912 147,632 96 501 65.0 1908-1912 730,152 355 684,300 73.2 Source: Statistisches Jahrbuch der Stadt Essen. Table 118 Mortality from Cancer in Munich 1896-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1896 415,500 542 130.4 1906 544,000 888 163.2 1897 430,000 632 147.0 1907 554,000 905 163.4 1898 446,000 604 135.4 1908 565,000 977 172.9 1899 466,000 669 143.6 1909 577,000 890 154.2 1900 490,000 598 122.0 135.5 1910 1906-1910 590,000 1,009 171.0 1896-1900 2,247,500 3,045 2,830,000 4,669 165.0 1901 503,000 707 140.6 1911 604,000 979 162.1 1902 509,000 715 140.5 1912 615,000 1,081 175.8 1903 515,000 749 145.4 1904 524,000 798 152.3 Source: Munchener Jahresiibersichten. 1905 534,000 812 152.1 146.3 Note. Includes all kinds of tu mors. 1901-1905 2,585,000 3,781 657 APPENDIX G Table 119 Mortality from Cancer in Munich, by Sex 1896-1911 MALES FEMALES Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1896 1897 1898 1899 1900 201,767 209,023 217,024 226,989 238,924 184 252 221 255 238 91.2 120.6 101.8 112.3 99.6 105.1 1896 1897 1898 1899 1900 1896-1900 213,733 220,977 228,976 239,011 251,076 358 380 383 414 360 1,895 167.5 172.0 167.3 173.2 143.4 1896-1900 1,093,727 1,150 1,153,773 164.2 1901 1902 1903 1904 1905 243,653 244,880 246,067 248,638 251,621 249 261 264 293 303 102.2 106.6 107.3 117.8 120.4 110.9 1901 1902 1903 1904 1905 1901-1905 259,347 264,120 268,933 275,362 282,379 458 454 485 505 509 176.6 171.9 180.3 183.4 180.3 1901-1905 1,234,859 1,370 1,350,141 2,411 178.6 1906 1907 1908 1909 1910 256,877 262,153 267,923 274,190 280,899 356 340 382 353 395 138.6 129.7 142.6 128.7 140.6 136.1 1906 1907 1908 1909 1910 1906-1910 287,123 291,847 297,077 302,810 309,101 532 565 595 537 614 185.3 193.6 200.3 177.3 198.6 1906-1910 1,342,042 1,826 1,487,958 2,843 191.1 1911 288,108 376 130.5 1911 315,892 603 190.9 Source: Note: MUnchener Jahresiibersichten. [ncludes all kinds of tumors. Table 120 Mortality from Cancer in Munich, by Religious Confession according to Organs and Parts, Females 1907-1909 All Cases of Carcinoma Carcinoma Mammae Number Per Cent. Carcinoma Uteri Number Per Cent. Christians Jews 1,326 102 120 9.0 17 16.7 381 28.7 7 6.8 Population, 1905: 10,056 Jews, 528,927 others. Source: A. Theilhaber and S. Greischer. Zur Aethiologie des Carcinoms. schrift fiir Krebsforschung, 9. Band. In: Zeit- 658 APPENDIX G Table 121 Table 122 Mortality from Cancer in ] Dresden Mortality from Cancer in Leipzig 1886-19 12 Deaths Rate per 1881-1912 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1886 249,150 247 99.1 1881 151,562 157 103.6 1887 254,950 257 100.8 1882 155,812 159 102.0 1888 261,300 288 110.2 1883 160,064 159 99.3 1889 267,750 281 104.9 1884 164,315 164 99.8 1890 273,900 329 120.1 107.3 1885 1881-1885 168,567 141 83.6 1886-1890 1,307,050 1,402 800,320 780 97.5 1891 280,550 344 122.6 1886 172,819 159 92.0 1892 304,050 352 115.8 1887 177,071 177 100.0 1893 312,900 380 121.4 1888 181,323 184 101.5 1894 322,050 377 117.1 1889 211,598 204 96.4 1895 332,100 386 116.2 118.5 1890 1886-1890 291,374 268 92.0 1891-1895 1,551,650 1,839 1,034,185 992 95.9 1896 341,400 382 111.9 1891 362,118 291 80.4 1897 369,800 476 128.7 1892 370,683 335 90.4 1898 380,500 402 105.7 1893 379,247 341 89.9 1899 388,400 468 120.5 1894 387,812 327 84.3 1900 393,550 492 125.0 118.5 1895 1891-1895 396,377 362 91.3 1896-1900 1,873,650 2,220 1,896,237 1,656 87.3 1901 400,900 506 126.2 1896 405,580 348 85.8 1902 405,600 537 132.4 1897 416,812 414 99.3 1903 491,500 588 119.6 1898 428,044 388 90.6 1904 501,800 617 123.0 1899 439,276 434 98.8 1905 511,050 606 118.6 123.5 1900 1896-1900 450,508 409 90.8 1901-1905 2,310,850 2,854 2,140,220 1,993 93.1 1906 519,700 626 120.5 1901 460,880 437 94.8 1907 527,600 672 127.4 1902 470,390 462 98.2 ■ 1908 535,550 693 129.4 1903 479,900 510 106.3 1909 539,850 692 128.2 1904 489,410 507 103.6 1910 543,800 700 128.7 126.9 1905 1901-1905 498,920 499 100.0 1906-1910 2,666,500 3,383 2,399,500 2,415 100.6 1911 551,150 763 139.2 1906 509,180 593 116.5 191?- 558,500 746 134.9 1907 518,682 591 113.9 1908 528,184 559 105.8 Source: Statistisches Jahrbuch flir die 1909 537,686 502 93.4 Stadt Dres >den. 1910 1906-1910 580,743 552 95.1 2,674,475 2,797 104.6 1911 595,710 582 97.7 1912 605,755 622 102.7 Source: Statistische Monatsberichte der Stadt Leipzig. Communications statistiques publiees par le Bu reau Municipal de Statistique d' Amsterdam, No. 33. 659 APPENDIX G Table 123 Table 124 Mortality from Cancer in Koenigs- Mortality from Cancer in ] Vurem- berg, 1881 -1912 Deaths Rate per berg, 1881 -1912 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 142,067 77 54.2 1881 101,500 77 75.9 1882 144,075 100 69.4 1882 104,510 95 90.9 1883 146,111 84 57.5 1883 106,310 101 95.0 1884 148,176 102 68.8 1884 108,810 102 93.7 1885 150,270 104 69.2 63.9 1885 1881-1885 112,760 120 106.4 1881-1885 730,699 467 533,890 495 92.7 1886 152,342 125 82.1 1886 116,550 160 137.3 1887 154,405 108 69.9 1887 120,360 122 101.4 1888 157,317 115 73.1 1888 125,990 141 111.9 1889 159,832 104 65.1 1889 133,010 128 96.2 1890 161,130 144 89.4 75.9 1890 1886-1890 139,640 144 103.1 1886-1890 785,026 596 635,550 695 109.4 1891 161,473 129 79.9 1891 145,550 146 100.3 1892 161,750 156 96.4 1892 148,370 141 95.0 1893 163,120 180 110.3 1893 149,850 133 88.8 1894 166,326 199 119.6 1894 153,960 138 89.6 1895 171,053 187 109.3 103.3 1895 1891-1895 159,530 193 121.0 1891-1895 823,722 851 757,260 751 99.2 1896 173,510 194 111.8 1896 166,310 189 113.6 1897 177,189 171 96.5 1897 175,580 176 100.2 1898 181,249 194 107.0 1898 192,120 193 100.5 1899 185,014 208 112.4 1899 240,640 256 106.4 1900 187,743 175 93.2 104.1 1900 1896-1900 254,180 232 91.3 1896-1900 904,705 942 1,028,830 1,046 101.7 1901 189,818 208 109.6 1901 265,180 245 92.4 1902 191,642 198 103.3 1902 267,730 261 97.5 1903 193,511 213 110.1 1903 272,170 270 99.2 1904 195,834 271 138.4 1904 280,000 290 103.6 1905 198,874 270 135.8 119.6 1905 1901-1905 291,200 299 102.7 1901-1905 969,679 1,160 1,370,280 1,365 99.2 1906 226,265 311 137.4 1906 298,946 300 100.4 1907 231,787 322 138.9 1907 306,691 308 100.4 1908 236,292 288 121.9 1908 314,436 315 100.2 1909 241,120 284 117.8 1909 322,181 322 99.9 1910 243,982 313 128.3 128.7 1910 1906-1910 329,926 346 104.9 1906-1910 1,179,446 1,518 1,572,180 1,591 101.2 1911 249,067 300 120.4 1911 337,671 356 105.4 1912 255,684 302 118.1 1912 345,416 382 110.6 Source: Communications statistiques publiees par le Bureau Municipal de Statis- tique d' Amsterdam, No. 33. Statistisches Jahrbuch fiir Kiinigsberg, 1908-1912. Source: Communications statistiques publiees par le Bureau Municipal de Statis- tique d' Amsterdam, No. 33. Bericht uber die Gesundtheitsverhalt- nisse und Gesundheitsanstalten in Niirn- berg. 660 APPENDIX G Table 125 Table 126 Mortality from Cancer in Holland Mortality from Cancer in Holland 1881-1913 Rate per by Sex, 1901-1913 Deaths MALES Year Population from 100,000 Cancer Population Deaths Rate per 1881 4,087,334 2,353 57.6 Year Population from Cancer 100,000 Population 1882 4,143,524 2,421 58.4 1901 2,577,318 2,367 91.8 1883 4,199,018 2,436 58.0 1902 2,614,568 2,573 98.4 1884 4,251,669 2,621 61.6 1903 2,651,817 2,668 100.6 1885 4,307,142 2,841 66.0 1904 2,689,067 2,642 98.2 1905 2,726,316 2,816 103.3 1881-1885 20,988,687 12,672 60.4 1886 4,363,434 2,925 67.0 1901-1905 13,259,086 13,066 98.6 1887 1888 1889 1890 4,420,864 4,478,401 4,527,264 4,537,990 2,887 3,111 3,411 3,332 65.3 69.5 75.3 73.4 70.2 79.4 1906 1907 1908 1909 1910 1906-1910 2,769,160 2,806,485 2,843,810 2,881,135 2,918,460 2,880 2,830 2,940 2,997 3,117 104.0 100.8 103.4 104.0 1886-1890 22,327,953 4,593,155 15,666 3,648 106.8 1891 14,219,050 14,764 103.8 1892 4,645,660 3,712 79.9 1893 4,701,243 3,798 80.8 1911 2,955,785 3,276 110.8 1894 4,764,279 3,859 81.0 1912 2,993,110 3,230 107.9 1895 4,827,549 4,122 85.4 1913 3,050,933 3,324 FEMALES 109.0 1891-1895 23,531,886 19,139 81.3 1901 2,639,925 2,527 95.7 1896 4,894,055 4,329 88.5 1902 2,678,079 2,467 92.1 1897 4,966,431 4,487 90.3 1903 2,716,234 2,663 98.0 1898 5,039,418 4,685 93.0 1904 2,754,388 2,714 98.5 1899 5,107,098 4,900 95.9 1905 2,792,543 2,802 100.3 1900 5,159,347 4,733 91.7 1901-1905 13,581,169 13,173 97.0 1896-1900 25,166,349 23,134 91.9 1901 1902 1903 1904 1905 5,217,243 5,292,647 5,368,051 5,443,455 5,518,859 4,894 5,040 5,331 5,356 5,618 93.8 95.2 99.3 98.4 101.8 97.8 1906 1907 1908 1909 1910 1906-1910 2,825,103 2,863,182 2,901,261 2,939,340 2,977,419 2,793 2,986 3,007 3,015 3,162 98.9 104.3 103.6 102.6 106.2 14,506,305 14,963 1901-1905 26,840,255 26,239 103.1 1906 5,594,263 5,673 101.4 1911 3,015,498 3,225 106.9 1907 5,669,667 5,816 102.6 1912 3,053,577 3,406 111.5 1908 5,745,071 5,947 103.5 1913 3,112,567 3,423 110.0 1909 5,820,475 6,012 103.3 1910 5,895,879 6,279 106.5 Source: Jaarcijfers voor het Koninkrijk der Nederlanden, 1906-1910 28,725,355 29,727 103.5 Bijdragen tot de Statistiek van Neder- land: Statistiek van de Sterfte naar den 1911 1912 5,971,283 6,046,687 6,501 6,636 108.9 109.7 Leeftijd e Dood. n naar de Oorzaken van den 1913 6,163,500 6,747 109.5 Source : Jaarcijfers voor het Koninkrijk der Nederlanden. Bijdrag en tot de Statistiek van Neder- land: Statistiek van de Sterfte naar den Leeftijd en naar de Oorzaken van den Dood. 661 APPENDIX G Table 127 Mortality from Cancer in Holland, by Organs and Parts, according to Sex 1906-1912 MALES Deaths Rate per Organ or Part from 100,000 Cancer Population Buccal cavity 761 5.26 Stomach and liver : 10,424 71.99 Peritoneum, intestines and rectum 1,680 11.60 Female generative organs Breast 11 0.08 Skin 250 1.73 Other or not specified organs 2,317 16.00 All organs 15,443 Source: Bijdragen tot de Statistiek vanNederland den Leeftijd en naar de Oorzaken van den Dood. Note: Includes only carcinoma. FEMALES Deaths Rate per from 100,000 Cancer Population 206 1.39 8,067 54.61 2,035 13.78 1,929 13.06 1,470 9.95 186 1.26 1,700 11.51 106.65 15,593 105.55 Statistiek van de Sterf te naar Table 128 Mortality from Cancer in Amsterdam 1881-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 338,047 244 72.2 1901 530,718 512 96.5 1882 350,201 254 72.5 1902 538,815 543 100.8 1883 361,326 246 68.1 1903 546,534 578 105.8 1884 366,660 276 75.3 1904 551,415 599 108.6 1885 372,325 284 76.3 72.9 1905 1901-1905 557,614 623 111.7 1881-1885 1,788,559 1,304 2,725,096 2,855 104.8 1886 378,686 290 76.6 1906 564,186 626 111.0 1887 390,016 282 72.3 1907 565,654 596 105.4 1888 399,424 300 75.1 1908 565,589 662 117.0 1889 408,061 385 94.3 1909 566,131 637 112.5 1890 417,539 343 82.1 80.3 1910 1906-1910 573,983 690 120.2 1886-1890 1,993,726 1,600 2,835,543 3,211 113.2 1891 426,914 372 87.1 1911 580,960 664 114.3 1892 437,892 399 91.1 1912 588,000 702 119.4 1893 446,657 390 87.3 1913 595,000 683 114.8 1894 450,189 394 87.5 1895 456,324 389 85.2 Source: Statistisch Jaarboek der Gemeente Amsterdam. Jaarcijfers voor het 1891-1895 2,217,976 1,944 87.6 Koninkrijk der Nederlanden. 1913. 1896 494,189 425 86.0 1897 503,285 472 93.8 1898 512,953 510 99.4 1899 510,853 540 105.7 1900 520,602 507 97.4 96.5 1896-1900 2,541,882 2,454 662 APPENDIX G Table 129 Mortality from Cancer in Amsterdam, by Sex 1901-1912 MALES FEMALES Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1901 251,820 219 87.0 1901 278,898 293 105.1 1902 256,160 284 110.9 1902 282,655 259 91.6 1903 260,590 263 100.9 1903 285,944 315 110.2 1904 263,151 285 108.3 1904 288,264 314 108.9 1905 266,381 312 117.1 105.0 1905 1901-1905 291,233 311 106.8 1901-1905 1,298,102 1,363 1,426,994 1,492 104.6 1906 269,850 310 114.9 1906 294,336 316 107.4 1907 270,344 284 105.1 1907 295,310 312 105.7 1908 270,230 317 117.3 1908 295,359 345 116.8 1909 269,723 301 111.6 1909 296,408 336 113.4 1910 273,976 316 115.3 112.8 1910 1906-1910 300,007 374 124.7 1906-1910 1,354,123 1,528 1,481,420 1,683 113.6 1911 1912 277,863 281,240 311 350 111.9 124.4 1911 1912 303,097 306,760 353 352 116.5 114.7 Source: Statistisch Jaarboek der Gemeente Amsterdam. Table 130 Mortality from Cancer in Amsterdam, by Organs and Parts, Males 1862-1902 Number or Deaths Percentage of All Deaths FROM CaHCINOMA FROM Carcinoma 186^2- 1872- 1886- 1897- 1862- 1872- 1886- 1897- Organ or Part 1867 1877 1891 1902 1867 1877 1891 1902 Tongue 10 20 24 37 2.9 4.4 2.9 2.8 Pharynx 2 1 7 16 0.6 0.2 0.8 1.2 Larynx 1 4 13 35 0.3 0.9 1.6 2.7 (Esophagus 16 24 92 159 4.6 5.3 11.2 12.2 Stomach 212 246 416 613 61.3 53.8 50.7 46.9 Intestines 9 11 26 71 2.6 2.4 3.2 5.4 Rectum 6 9 25 66 1.7 2.0 3.0 5.0 Liver 39 69 91 133 11.3 15.1 11.1 10.2 Peritoneum 3 2 4 8 0.9 0.4 0.5 0.6 Vesica urinaria 2 9 22 28 0.6 2.0 2.7 2.1 Breast 1 2 0.0 0.0 0.1 0.2 Bones 4 12 5 17 1.2 2.6 0.6 1.3 Skin 4 5 12 19 1.2 1.1 1.5 1.5 Other organs 9 19 59 68 2.6 4.2 7.2 5.2 Not specified 29 26 23 36 8.2 5.6 2.9 2.7 All carcinoma 346 457 820 1,308 100.0 100.0 100.0 100.0 Source: Communications Statistiques publiees par le Bureau Municipal de Statis- tique d' Amsterdam, No. 26. Amsterdam, 1911. 663 APPENDIX G Table 131 Mortality from Cancer in Amsterdam, by Organs and Parts, Females 1862-1902 Number of Deaths Pebcentage of All Deaths FBOII CaBCLN'OMA ' FBOM CaBCISOMA 1862- 1872- 1886- 1897- 186-2- 1872- 1886- 1897- OrganorPart 1867 1877 1891 1902 1867 1877 1891 1902 Tongue 3 3 0.0 0.0 0.3 0.2 Pharj-nx 1 .. 1 2 0.2 0.0 0.1 0.1 LarjTix 3 1 1 0.0 0.5 0.1 0.1 (Esophagus 2 3 12 31 0.4 0.5 1.1 2.0 Stomach 133 197 305 464 25.7 30.4 33.8 29.2 Intestines 9 15 19 93 1.7 2.3 1.8 5.9 Rectum 6 6 23 54 1.2 0.9 2.1 3.4 Liver 65 98 156 242 12.6 15.1 14.5 15.2 Peritoneum 4 4 11 28 0.8 0.6 1.0 1.8 Vesica urinaria 2 16 24 0.0 0.3 1.5 1.5 Breast 77 83 123 158 14.9 12.8 11.4 9.9 Ovaries 1 3 10 28 0.2 0.5 0.9 1.8 Uterus 156 174 240 317 30.2 26.8 22.2 20.0 Vagina 7 3 5 7 1.4 0.5 0.5 0.4 Vulvae 1 2 9 0.0 0.2 0.2 0.6 Bones 2 5 4 11 0.4 0.8 0.4 0.7 Skin 7 7 6 10 1.4 1.1 0.6 0.6 Other organs 9 14 33 44 1.7 2.1 3.1 2.8 Not specified 38 31 49 62 ' 7.2 4.6 4.4 3.8 All carcmoma 517 649 1,079 1,588 ; 100.0 100.0 100.0 100.0 Source: Comnnmications Statistiques publiees par le Bureau Municipal de Statis- tique d'Amsterdam, No. 26. Amsterdam, 1911. Table 132 Mortality from Cancer in Amsterdam, by Organs and Parts according to Age, Males 1897-1902 Number of Deaths fbou Carcinoma 34 and 75 and Organ or Part Under 35-44 45-54 55-64 65-74 Over Total Buccal ca\nty and pharnj-x .... 1 13 21 15 10 60 (Esophagus 1 9 34 46 54 15 159 Stomach 5 27 98 224 187 72 613 Intestines and rectum 5 10 20 43 45 14 137 Liver 3 3 26 48 35 18 133 Otherorgans 6 15 43 60 56 26 206 -\11 carcinoma 20 65 234 442 392 155 1,308 Pehcentage of Aix Ages Buccal ca^•ity and pharjmx . . 0.0 1.7 21.7 35.0 25.0 16.6 100.0 (Esophagus 0.6 5.7 21.4 28.9 34.0 9.4 100.0 Stomach 0.8 4.4 16.0 36.5 30.5 11.8 100.0 Intestines and rectum 3.6 7.3 14. G 31.5 32.8 10.2 100.0 Liver 2.3 2.3 19.5 36.1 26.3 13.5 100.0 Otherorgans 2.9 7.3 20.9 29.1 27.2 12.6 100.0 All carcinoma 1.5 5.0 17.9 33.8 30.0 11.8 100.0 Source: Communicatirns Statistiques publiees par le Bureau Municipal de Statis- tique d'Amsterdam, No. 26. Amsterdam, 1911. 6G4 APPENDIX G Table 133 Mortality from Cancer in Amsterdam, by Organs and Parts according to Age, Females 1897-1902 Number of Deaths from Carcinoma 34 and 75 and Organ or Part Under 35-44 45-54 55-04 e5-74 Over Total Buccal cavity and pharynx . . 1 2 1 1 1 1 7 (Esophagus 2 .. 8 12 9 31 Stomach 3 24 57 128 152 100 464 Intestines and rectum 4 7 26 48 43 20 148 Liver 2 13 21 71 83 52 242 Breast 4 17 42 41 38 16 158 Uterus 21 45 95 90 51 15 317 Other organs 4 20 45 63 49 40 221 All carcinoma 39 130 287 450 429 253 1,588 Percentage of All Ages Buccal cavity and pharynx. . 14.3 28.5 14.3 14.3 14.3 14.3 100.0 (Esophagus 0.0 6.5 0.0 25.8 38.7 29.0 100.0 Stomach 0.6 5.2 12.3 27.6 32.8 21.5 100.0 Intestines and rectum 2.7 4.7 17.6 32.4 29.1 13.5 100.0 Liver 0.8 5.4 8.7 29.3 34.3 21.5 100.0 Breast 2.5 10.8 26.6 25.9 24.1 10.1 100.0 Uterus 6.6 14.2 30.0 28.4 16.1 4.7 100.0 Otherorgans 1.8 9.0 20.4 28.5 22.2 18.1 100.0 All carcinoma 2.5 8.2 18.1 28.3 27.0 15.9 100.0 Source: Communications Statistiques publiees par le Bureau Municipal de Statis- tique d'Amsterdam, No. 26. Amsterdam, 1911. Table 134 Mortality from Cancer in The Hague 1901-1913 Deaths Rate per Year Population from 100,000 Cancer Population 1901 215,120 209 97.2 1902 220,253 229 104.0 1903 226,140 255 112.8 1904 232,132 244 105.1 1905 238,257 239 100.3 1901-1905 1,131,902 1,176 103.9 1906 245,525 263 107.1 1907 251,749 278 110.4 1908 256,758 272 105.9 1909 264,561 271 102.4 1910 275,312 318 115.5 1906-1910 1,293,905 1,402 108.4 1911 284,547 305 107.2 1912 294,540 324 110.0 1913 298,272 373 125.1 Source: Statistiek van de Sterfte naar den Leeftijd en naar de Oorzaken van den Dood (Statistiek van Nederland). 665 APPENDIX G Table 135 Mortality from Cancer in The Hague, by Sex, 1901-1912 MALES FEMALES Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1901 97,243 81 83.3 1901 117,877 128 108.6 1902 99,596 95 95.4 1902 120,657 134 111.1 1903 102,384 118 115.3 1903 123,756 137 110.7 1904 105,257 115 109.3 1904 126,875 129 101.7 1905 108,381 104 96.0 100.0 19,05 1901-1905 129,876 135 103.9 1901-1905 512,861 613 619,041 663 107.1 1906 112,065 118 105.3 1906 133,460 145 108.6 1907 114,912 126 109.6 1907 136,837 152 111.1 1908 117,095 116 99.1 1908 139,663 156 111.7 1909 120,619 115 95.3 1909 143,942 156 108.4 1910 125,398 133 106.1 103.1 1910 1906-1910 149,914 185 123.4 1906-1910 590,089 608 703,816 794 112.8 1911 129,505 152 117.4 1911 155,042 153 98.7 1912 133,948 139 103.8 1912 160,592 185 115.2 Source: Statistiek van de Sterfte naar den Leeftijd en naar de Oorzaken Dood (Statistiek van Nederland). van den Table 136 Mortality from Cancer in Rotterdam 1901- 1913 Year Population Deaths from Cancer Rate per 100,000 Population 1901 1902 1903 1904 1905 341,051 348,474 357,474 370,390 379,017 272 275 336 304 323 79.8 78.9 94.0 82.1 85.2 1901-1905 1,796,406 1,510 84.1 1906 1907 1908 1909 1910 390,364 403,355 411,635 417,780 426,888 370 382 348 344 394 94.8 94.7 84.5 82.3 92.3 1906-1910 2,050,022 1,838 89.7 1911 1912 1913 436,018 445,137 453,128 462 432 433 106.0 97.0 95.6 Source: Statistiek van de Sterfte naar den Leeftijd en naar de Oorzaken van den Dood (Statistiek van Nederland). 666 APPENDIX G Table 137 Mortality from Cancer in Rotterdam, by Sex 1901-1912 MALES FEMALES Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1901 163,650 115 70.3 1901 177,401 157 88.5 1902 167,542 129 77.0 1902 180,932 146 80.7 1903 172,244 . 151 87.7 1903 185,230 185 99.9 1904 178,680 131 73.3 1904 191,710 173 90.2 1905 183,045 152 83.0 78.4 1905 1901-1905 195,972 171 87.3 1901-1905 865,161 678 931,245 832 89.3 1906 189,036 181 95.7 1906 201,328 189 93.9 1907 195,678 173 88.4 1907 207,677 209 100.6 1908 199,754 172 86.1 1908 211,881 176 83.1 1909 202,627 152 75.0 1909 215,153 192 89.2 1910 207,716 185 89.1 86.8 1910 1906-1910 219,172 209 95.4 1906-1910 994,811 863 1,055,211 975 92.4 1911 212,561 203 95.5 1911 223,457 259 115.9 1912 217,528 195 89.6 1912 227,609 237 104.1 Source : Statistiek van de Sterfte naar den Leeftijd en naar de Oorzaken Dood (Statistiek van Nederland). van den Table 138 Table 139 Mortality from Cancer in Belgium Mortality from Cancer in Belgium 1903- 1912 Rate per Mai 1903- es 1912 Deaths Year Population from 100,000 Deaths Rate per Cancer Population Year Population from 100,000 1903 6,876,303 4,084 59.4 Cancer Population 1904 6,949,300' 3,969 57.1 1903 3,417,523 1,849 54.1 1905 7,022,297 4,203 59.9 1904 3,453,802 1,771 51.3 1905 3,490,082 1,825 52.3 1906 7,095,294 4,232 59.6 1907 7,168,291 4,396 61.3 1906 3,519,266 1,892 53.8 1908 7,241,288 4,713 65.1 1907 3,555,472 1,970 55.4 1909 7,314,285 4,786 65.4 1908 3,591,679 2,068 57.6 1910 7,387,282 4,699 63.6 1909 1910 3,627,885 3,664,092 2,189 2,083 60.3 56.8 1906-1910 36,206,440 22,826 63.0 1906-1910 17,958,394 10,202 56.8 1911 7,460,279 5,140 68.9 1912 7,533,276 5,374 71.3 1911 3,700,298 2,309 62.4 1912 3,736,505 2,476 66.3 Source : Annuaire Statistique de la Bel- gique. Source: Annuaire Statistique de la Bel- gique. 667 APPENDIX G Table 140 Table 141 Mortality from Cancer in Belgium Mortality from Cancer in Liege Females 1903- 1912 1903- 912 Ti^iatVic Deaths Rate per Year Population from iv3.tc per 100,000 Year Population from 100,000 Cancer Population Cancer Population 1903 166,280 131 78.8 1903 3,458,780 2,235 64.6 1904 166,455 143 85.9 1904 3,495,498 2,198 62.9 1905 166,630 163 97.8 1905 3,532,215 2,378 67.3 1906 166,805 120 71.9 1906 3,576,028 2,340 65.4 1907 166,980 160 95.8 1907 3,612,819 2,426 67.1 1908 167,155 187 111.9 1908 3,649,609 2,645 72.5 1909 167,330 153 91.4 1909 3,686,400 2,597 70.4 1910 167,505 174 103.9 1910 3,723,190 2,616 70.3 1906-1910 835,775 794 95.0 1906-1910 18,248,046 12,624 69.2 1911 167,676 187 111.5 1911 3,759,981 2,831 75.3 1912 167,851 177 105.5 1912 3,796,771 2,898 76.3 Source: Rapport Annuel des Servnces Source: Annuaire Statistique de la Bel- de L'Etat Civil et de la Population. gique. Table 142 Mortality from Cancer in Liege, by Sex 1905-1912 MALES FEjNIALES Year 1905 Population 79,566 Deaths from Cancer 67 Rate per 100,000 Population 84.2 Year 1905 Population 87,064 Deaths from Cancer 96 Rate per 100,000 Population 110.3 1906 1907 1908 1909 1910 79,499 79,432 79,365 79,298 79,230 54 69 72 72 79 67.9 86.9 90.7 90.8 99.7 87.2 1906 1907 1908 1909 1910 1906-1910 87,306 87,548 87,790 88,032 88,275 66 91 115 81 95 75.6 103.9 131.0 92.0 107.6 1906-1910 396,824 346 438,951 448 102.1 1911 1912 79,177 79,108 81 77 102.3 97.3 1911 1912 88,499 88,743 106 100 119.8 112.7 Source: Rapport Annuel des Services de L'Etat Civil et de la Population. 668 APPENDIX G Table 143 Mortality from Cancer in Antwerp 1896-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1896 260,568 124 47.6 1906 295,941 205 69.3 1897 264,198 149 56.4 1907 299,416 218 72.8 1898 267,829 150 56.0 1908 302,891 262 86.5 1899 271.460 155 57.1 1909 306,366 300 97.9 1900 275,091 156 56.7 54.8 1910 1906-1910 309,841 261 84.2 1896-1900 1,339,146 734 1,514,455 1,246 82.3 1901 278,566 173 62.1 1911 313,316 260 83.0 1902 282,041 180 63.8 1912 322,275 293 90.9 1903 285,516 202 70.7 1904 288,991 203 70.2 Source : Stad Antwerpen. Gezond- 1905 292,466 213 72.8 68.0 heidsbureel : Volksbeschrijvende Statistiek. 1901-1905 1,427,580 971 Table 144 Mortality from Cancer in Brussels 1901-1912 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1901 187,145 165 88.2 1906 182,110 168 92.3 1902 186,138 151 81.1 1907 181,103 205 113.2 1903 185,131 160 86.4 1908 180,096 187 103.8 1904 184,124 183 99.4 1909 179,090 185 103.3 1905 183,117 172 93.9 89.8 1910 1906-1910 178,084 181 101.6 1901-1905 925,655 831 900,483 926 102.8 1911 177,078 198 111.8 1912 176,947 188 106.2 Source: Annual. Note: Villa de Bruxelles. Rapport Demographie Statistique. Without suburbs. 669 APPENDIX G Table 145 Mortality from Cancer in France 1892-1911 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1892 12,223,548 10,761 88.0 1906 39,282,000 27,306 69.5 1893 12,223,548 11,442 93.6 1907 39,279,000 29,284 74.6 1894 12,223,548 11,607 95.0 1908 39,368,000 30,124 76.5 1895 12,223,548 11,955 97.8 1909 39,421,000 1910 39,528,000 30,645 31,303 77.7 79.2 1892-1895 48,894,192 45,765 93.6 1906-1910 196,878,000 148,662 75.5 1896 12,869,412 12,212 94.9 1897 12,869,412 12,631 98.1 1911 39,602,000 31,768 80.2 1898 12,869,412 12,789 99.4 1899 12,869,412 13,161 102.3 Source : Annual Report of the Registrar- 1900 12,869,412 13,392 104.1 General of Births, Deaths and Marriages in England and Wales, 1911. 1896-1900 64,347,060 64,185 99.7 Note: Previous to 1906 the data are for 1901 13,771,440 12,385 89.9 cities with more than only. 5,000 inhabitants 1902 13,771,440 12,463 90.5 1903 13,771,440 12,912 93.8 1904 13,771,440 13,312 96.7 1905 13,771,440 13,793 100.2 94.2 1901-1905 68,857,200 64,865 Table 146 Mortality from Cancer in Cities of France, according to Size 1906-1910 Size of Cities Population Paris 13,862,165 100,000-518,000 population 13,713,307 30,000-100,000 population 14,265,701 20,000-30,000 population 7,090,747 10,000-20,000 population 10,666,695 5,000-10,000 population 12,376,876 Under 5,000 population 124,902,507 Total, all France 196,877,998 Source: Annuaire Statistique de la France. Deaths Rate per from 100,000 Cancer Population 15,385 111.0 16,313 119.0 16,319 114.4 7,066 99.7 9,591 89.9 8,969 72.5 75,019 60.1 148,662 75.5 670 APPENDIX G Table 147 Mortality from Cancer in 1881-1913 Paris Rate per 100,000 Population 97.2 97.7 94.0 94.9 98.2 96.4 100.4 97.7 98.9 98.8 97.1 98.6 99.5 94.9 99.2 102.4 102.6 99.8 105.2 107.0 107.1 105.2 104.2 105.7 108.9 105.9 109.3 107.1 114.1 109.1 114.9 111.1 111.1 109.0 108.9 111.0 112.6 112.4 110.9 le de la Mortal Year 1893 1894 1895 1896 1897 1898 1899 1900 1896-1900 1901 1902 1903 1904 1905 1901-1905 1906 1907 1908 1909 1910 1906-1910 1911 1912 1913 Source: Yille de Pa Table 1 ity from d Males, 189 48 mcer in 3-1913 Deaths from Cancer 851 892 963 982 1,044 1,059 1,066 1,066 Paris Year 1881 1882 1883 1884 1885 Population 2,239,928 2,244,131 2,248,334 2,252,537 2,256,741 Deaths from Cancer 2,178 2,193 2,114 2,137 2,215 Population 1,184,483 1,189,883 1,195,491 1,200,810 1,212,255 1,223,377 1,234,689 1,245,671 Rate per 100,000 Population 71.8 75.0 80.6 81.8 86 1 1881-1885 1886 1887 1888 1889 1890 11,241,671 2,260,945 2,293,697 2,326,449 2,359,201 2,391,953 10,837 2,269 2,240 2,301 2,332 2,323 86.6 86.3 85.6 6,116,802 1,256,848 1,260,316 1,263,762 1,267,185 1,270,857 5,217 1,081 1,054 1,132 1,093 1,184 85.3 86.0 83 6 1886-1890 1891 1892 1893 1894 1895 11,632,245 2,424,705 2,442,089 2,459,474 2,476,859 2,494,244 11,465 2,413 2,318 2,440 2,537 2,560 89.6 86.3 93.2 6,318,968 1,274,510 1,286,967 1,299,439 1,311,926 1,324,428 5,544 1,189 1,110 1,177 1,199 1,189 87.7 93.3 86 2 1891-1895 1896 1897 1898 1899 1900 12,297,371 2,511,629 2,541,415 2,571,201 2,600,987 2,630,773 12,268 2,642 2,719 2,753 2,735 2,740 90.6 91.4 89.8 6,497,270 1,337,121 1,348,879 1,360,666 Annuaire ris. 5,864 1,297 1,270 1,327 Statistic 90.3 97.0 94 2 1896-1900 1901 1902 1903 1904 1905 12,856,005 2,660,559 2,672,993 2,685,427 2,697,861 2,710,295 13,589 2,898 2,832 2,936 2,890 3,093 97.5 jue de la 1901-1905 1906 1907 1908 1909 1910 13,427,135 2,722,731 2,747,582 2,772,433 2,797,284 2,822,135 14,649 3,129 3,053 3,080 3,050 3,073 1906-1910 13,862,165 1911 2,847,229 1912 2,872,400 1913 2,897,500 Source : Annuaire Ville de Paris. 15,385 3,205 3,230 3,212 Statistiqi. 44 671 APPENDIX G Table 149 Mortality from Cancer in Paris, Females 1893-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1893 1,274,991 1,589 124.6 1906 1,448,221 1,940 134.0 ■ 1894 1,286,976 1,645 127.8 1907 1,460,615 1,943 133.0 1895 1,298,753 1,597 123.0 1908 1,472,994 1,903 129.2 1909 1,485,358 1,851 124.6 1896 1897 1,310,819 1,329,160 1,660 1,675 126.6 126.0 1910 1,497,707 l,88t 125.8 1898 1,347,824 1,694 125.7 1906-1910 7,364,895 9,521 129.3 1899 1,366,298 1,669 122.2 1900 1,385,102 1,674 120.9 1911 1,510,108 1,908 126.3 1912 1913 1,523,521 1,536,834 1,960 1,885 1 28 fi 1896-1900 6,739,203 8,372 124.2 122.7 1901 1,403,711 1,817 129.4 Source : Annuaire Statistique de la 1902 1,412,677 1,778 125.9 Ville de Paris. 1903 1,421,665 1,804 126.9 1904 1,430,676 1,797 125.6 1905 1,439,438 1,909 1.S2.6 128.1 1901-1905 7,108,167 9,105 Table 150 Mortality from Cancer in Lyons, 1910-1912 Deaths Rate per Year Population from 100,000 Cancer Population 1910 513,460 783 152.5 1911 523,798 805 153.7 1912 534,132 757 141.7 1910-1912 1,571,388 2,345 149.2 Source: Yille de Lyon, Bureau Municipal d'Hygiene et de statistique. Table 151 Table 152 Mortality from Cancer in Bordeaux Mortality from Cancer in Nice 1909-1912 Rate per 100,000 Population Year 1909-19] 12 Deaths from Cancer Year Population Deaths from Cancer Population Rate per 100,000 Population 1909 1910 1911 1912 257,786 259,732 261,678 263,624 262 291 309 322 101.6 112.0 118.1 122.1 113.5 1909 1910 1911 1912 1909-1912 139,456 141,198 142,940 144,682 134 141 155 137 96.1 99.9 108.4 94.7 1909-1912 1,042,820 1,184 568,276 567 99.8 Source: Original data furnished by the Mayor of the City of Bordeaux. Source: Original data furnished by the Bureau d'Hygiene, Nice. 672 APPENDIX G Table 153 Mortality from Cancer in Lille 1891-1912 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1891 201,211 241 119.8 1906 205,625 261 126.9 1892 204,224 234 114.6 1907 208,061 248 119.2 1893 207,237 254 122.6 1908 210,497 246 116.9 1894 210,250 239 113.7 1909 212,933 305 143.2 1895 213,263 1,036,185 252 118.2 ■ 117.7 1910 1906-1910 215,369 311 144.4 1891-1895 1,220 1,052,485 1,371 130.3 1896 1897 1898 216,276 216,107 215,938 235 216 254 108.7 100.0 117.6 1911 1912 217,807 220.243 316 291 145.1 132.1 1899 1900 215,769 215,600 235 267 108.9 123.8 111.8 Source: pal d'Hygi Ville de Lille. Burea ene. Travaux statisi u Munici- iques. 1896-1900 1,079,690 1,207 1901 215,431 248 115.1 1902 213,470 243 113.8 1903 211,509 246 116.3 1904 209,548 239 114.1 1905 207,587 265 1,241 127.7 117.3 1901-1905 1,057,545 Table 154 Table 155 Mortality from Cancer in Nancy Mortality from Cancer in Le H^vre 1901-1912 eaths rom ancer Rate per 100,000 Population Year 1901-1912 Year D Population i C Population Deaths from Cancer Rate per 100,000 Population 1901 1902 1903 1904 1905 102,559 104,298 106,037 107,776 109,515 116 118 132 119 141 113.1 113.1 124.5 110.4 128.7 118.1 1901 1902 1903 1904 1905 1901-1905 130,196 130,642 131.089 131,536 131,983 154 142 138 167 153 118.3 108.7 105.3 127.0 115.9 1901-1905 530,185 626 655,446 754 115.0 1906 1907 1908 1909 1910 111,254 112,993 114,732 116,471 118,210 145 144 172 129 136 130.3 127.4 149.9 110.8 115.0 126.6 1906 1907 1908 1909 1910 1906-1910 132,430 133,175 133,921 134,667 135,413 177 144 195 204 160 133.7 108.1 145.6 151.5 118.2 1906-1910 573,660 726 669,606 880 131.4 1911 1912 119,949 121.688 128 140 106.7 115.0 1911 1912 136,159 136,905 166 192 121.9 140.2 Source: Yille de Nancy, tistique et Demographique Annuaire Sta- Source: Rapport de la commission con- sultative du Bureau Municipal d'Hygiene. Ville du Havre. 673 APPENDIX G Table 156 Mortality from Cancer in Switzer- land, 1881-1912 Year 1881 1882 1883 1884 1885 Population 1,115,193 1,673,700 1,851,993 1,865,861 2,896,079 Deaths from Cancer 1,398 1,817 1,928 2,086 3,089 1881-1885 9,402,826 10,318 Rate per 100,000 Population 125.4 108.6 104.1 lll.S 106.7 109.7 1886-1890 14,643,955 16,718 1891-1895 15,197,361 18,612 1896-1900 16,127,599 20,544 1901-1905 17,142,770 21,995 1906-1910 18,237,395 22,903 1886 2,906.983 3,294 113.3 1887 2,917,887 3,276 112.3 1888 2,928,791 3,389 115.7 1889 2,939,695 3,354 114.1 1890 2,950,599 3,405 115.4 114.2 1891 2,965,053 3,528 119.0 1892 3,002,263 3,706 123.4 1893 3,039,472 3,653 120.2 1894 3,076,682 3,802 123.6 1895 3,113,891 3,923 126.0 12-2.5 1896 3,151,101 3,916 124.3 1S97 3,188,310 4,088 128.2 1898 3,225,520 4,125 127.9 1899 3,262,729 4,1.30 126.6 1900 3,299,939 4,285 129.9 127.4 1901 3,340,984 4,271 127.8 1902 3,384,769 4,258 125.8 1903 3,428,554 4,447 129.7 1904 3,472,339 4,464 128.6 1905 3,516,124 4,555 129.5 128.3 1906 3,559,909 4,593 129.0 1907 3,603,694 4,413 122.5 1908 3,647,479 4,669 128.0 1909 3,691,264 4.676 126.7 1910 3,735,049 4,612 123.5 125.9 1911 3,781,430 4,673 123.6 1912 3,831,220 4,-598 120.0 Source: Die Bewegung der Bevolker- ung in der Schweiz im Jahre 1881-1885. Ehe, Geburt und Tod in der Schweizeri- sciien Bevolkerung wahrend der zwanzig Jahre 1871-1890. Statistiches Jahrbuch der Schweiz 1912. Note: Does not include all the can- tons, 1881-1884. Table 157 Mortality from Cancer in Switzer- land, Males 1881-1885, 1901-1912 Year 1881 1882 1883 1884 1885 Population 546.445 820,113 907,477 914,272 1,419,079 Deaths Rate per from Cancer 662 874 875 950 1,456 1881-1885 4,607,386 4,817 1901 1902 1903 1904 1905 1,637,082 1,658,537 1,679,991 1,701,446 1,722,901 2,128 2,102 2,202 2,250 2,252 1901-1905 8,399,957 10,934 1906 1907 1908 1909 1910 1,744.355 1,765,810 1,787,265 1,808,719 1,830,174 2.342 2,190 2,318 2,271 2,310 100,000 Population 121.1 106.6 96.4 103.9 102.6 104.5 130.0 126.7 131.1 132.2 130.7 130.2 134.3 124.0 129.7 125.6 126.2 1906-1910 8,936,323 11,431 127.9 1911 1912 1,852,901 1,877,298 2,342 2,349 126.4 125.1 Source: Die Bewegtmg der Bevolker- ung in der Schweiz im Jahre 1881-1885. Ehe, Geburt und Tod in der Schweizeri- schen Bevolkerung wahrend der zwanzig Jahre 1871-1890. Statistisches Jahrbuch der Schweiz 1912. Note: Does not include aU the can- tons, 1881-1884. 674 APPENDIX G Table 158 Mortality from Cancer in Switzerland, Females, 1881-1885, 1901-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 568,748 736 129.4 1906 1,815,554 2,251 124.0 1882 853,587 943 110.5 1907 1,837,884 2,223 121.0 1883 944,516 1,053 111.5 1908 1,860,214 2,351 126.4 1884 951,589 1,136 119.4 1909 1,882,545 2,405 127.8 1885 1,477,000 1,633 5,501 110.6 114.7 1910 1906-1910 1,904,875 2,302 120.8 1881-1885 4,795,440 9,301,072 11,532 124.0 1901 1,703,902 2,143 125.8 1911 1,928,529 2,331 120.9 1902 1,726,232 2,156 124.9 1912 1,953,922 2,249 115.1 1903 1,748,563 2,245 128.4 Source: Die Bewegune der Bevblker- 1904 1,770,893 2,214 125.0 ling in der Schwciz im Jahre 1881-1885. 1905 1,793,223 2,303 128.4 Ehe, Geburt und Tod in der Schweizeri- schen Bevolkerung wahrend der zwanzig 1901-1905 8,742,813 11,061 126.5 Jahre 1871-1890. Statistisches Jahrbuch der Schweiz 1912. Note: Does not include all the can- tons, 1881-1884. Table 159 Mortality from Cancer in Switzerland, by Organs and Parts according to Sex, 1901-1910 Deaths from Cancek Organ or Part Total Males Females Tongue 516 478 38 (Esophagus 4,067 3,447 620 Larynx 1,093 946 147 Stomach 18,235 10,256 7,979 Intestines 2,220 937 1,283 Rectum 1,683 981 702 Bladder 604 434 170 Prostate 311 311 Breast 2,394 14 2,380 Uterus 3,299 . . 3,299 Vagina, testicle, etc 304 97 207 Ovaries 508 . . 508 Lips 153 129 24 Skin, face and nose 666 269 397 Thyroid gland 680 339 341 Liver and gall-bladder. 3,277 1,270 2,007 Spleen 17 8 9 Pancreas '. 545 294 251 Peritoneum 368 111 257 Lungs and pleura 236 138 98 Kidneys 254 144 110 Bones and jaw 427 246 181 Other organs 784 376 408 Sarcoma 2,317 1,140 1,177 All organs 44,958 22,365 22,593 Source: Statistisches Jahrbuch der Schweiz, 1912. Rate per 100,000 Population Total Males Females 1.46 2.76 0.21 11.50 19.88 3.44 3.09 5.46 0.81 51.54 59.16 44.22 6.27 5.40 7.11 4.76 5.66 3.89 1.71 2.50 0.94 0.86' 1.79 6.77 0.08 13.19 9.32 18.28 0.86 0.56 1.15 1.44 2.82 0.43 0.74 0.13 1.88 1.55 2.20 1.92 1.96 1.89 9.26 7.33 11.12 0.05 0.05 0.05 1.54 1.70 1.39 1.04 0.64 1.42 0.67 0.80 0.54 0.72 0.83 0.61 1.21 1.42 1.00 2.22 2.17 2.26 6.55 6.58 6.52 127.07 129.01 125.21 675 APPENDIX G Table 160 Mortality from Cancer in Switzerland, 1901-1910 Relative Mortality of Females, by Organs and Parts Rate per 100,000 Population Organ or Part Males Females Breast 0.08 13.19 Generative organs 0.56 22.25 Peritoneum 0.64 1.42 Liver and gall-bladder 7.33 11.12 Skin, face and nose 1.55 2.20 Other or not specified organs 2.17 2.26 Sarcoma 6.58 6.52 Intestines, rectum and pancreas 12.81 12.44 Thyroidgland 1.96 1.89 Stomach 59.16 44.22 Bonesandjaw 1.42 1.00 Lungs and pleura 0.80 0.54 Kidneys and bladder 3.33 1.55 Lips 0.74 0.13 (Esophagus 19.88 3.44 Larynx 5.46 0.81 Tongue 2.76 0.21 Relative Mortality of Females 16,488 3,973 222 152 142 104 99 97 96 75 70 68 47 18 17 15 97 All organs 129.01 125.21 Note: In this table the mortality of males from cancer of any organ or part is taken as 100 and the corresponding mortality of females is given accordingly. Table 161 Mortality from Cancer in Switzerland, by Organs and Parts according to Sex, 1906-1910 MALES Deaths Rate per Organ or Part from 100,000 Cancer Population Lips 74 0.8 Tongue 265 3.0 (Esophagus *.'. 1,763 19.7 Stomach 5,045 56.5 Liver and gall-bladder 707 7.9 Peritoneum and mesentery 54 0.6 Intestines 515 5.8 Rectum 544 6.1 Pancreas 168 1.9 Ovaries Uterus Breast 10 0.1 Skin 123 1.4 Larynx 520 5.8 Lungs and pleura 72 0.8 Kidneys . 67 0.7 Bladder 204 2.3 Prostate 194 2.2 Other or not specified 478 5.3 Sarcoma 628 7.0 All organs 11,431 127.9 Males, 45 years and over, 21.51 percent, of population. 23.66 per cent, of population. (Census of 1900.) FEMALES Deaths Rate per from 100,000 Cancer Population 9 0.1 20 0.2 304 3.3 3,987 42.9 1,032 11.1 124 1.3 695 7.5 370 4.0 138 1.5 276 3.0 1,609 17.3 1,264 13.6 221 2.4 78 0.8 60 0.6 60 0.6 84 0.9 56 i 6.6 640 6.9 11,532 124.0 Females, 45 years and over. 676 APPENDIX G Table 162 Mortality from Cancer in Switzerland, by Cantons and Race 1906-1910 Canton Population Zurich 2,370,861 Bern 3,242,609 Luzern 806,093 Uri 107,601 Schwyz 304,565 Obwalden 83,892 Niedwalden 71,126 Glarus 178,726 Zug 138,604 Soluthorn 554,417 Basel-Stadt 616,424 Basel-Land 377,514 Schaffhausen. . .- 227,967 Appenzell A.-Rh 304,565 Appenzell I.-Rh 74,773 St. GaUen 1,376,923 Aargau 1,136,190 Thurgau 621,895 Total German 12,594,745 Fribourg 703,963 Vaud 1,548,355 Valais 629,190 Neuchatel 694,845 Geneve 729,496 Total French, 4,305,849 Ticino 762,323 Grisons 574,478 Italian and Romanish 1,336,801 Deaths Rate per from 100,000 Cancer Population 3,255 137.3 3,224 99.4 1,342 166.5 123 114.3 453 148.7 131 156.2 119 167.3 308 172.3 208 150.1 672 121.2 704 114.2 401 106.2 258 113.2 412 135.3 136 181.9 2,040 148.2 1,497 131.8 876 140.9 16,159 128.3 825 117.2 1,538 99.3 280 44.5 686 98.7 931 127.6 4,260 98.9 684 89.7 578 100.6 l,s 94.4 Table 163 Mortality from Cancer in Switzerland, by Age and Sex 1901-1910 MALES FEMALES Deaths Rate per Deaths Rate per Summary from 100,000 Summary from 100,000 Ages Population Cancer Population Ages Population Cancer Population Under 20 7,182,421 196 2.7 Under 20 7,159,813 166 2.3 20-29 3,035,583 205 6.8 20-29 3,096,331 207 6.7 30-39 2,404,542 543 22.6 30-39 2,468,403 900 36.5 40-49 1,790,838 2,253 125:8 40-49 1,918,065 2,829 147.5 50-59 1,423,308 5,377 377.8 50-59 1,620,341 5,101 314.8 60-69 970,832 8,000 824.0 60-69 1,151,200 7,319 635.8 70-79 447,276 4,971 1,111.4 70-79 528,686 4,972 940.4 80 and over 81,480 820 1,006.4 129.0 80 and ov All Ages er 101,046 1,099 1,087.6 All Ages 17,336,280 22,365 18,043,885 22,593 125.2 Source : Statistisches Jahrbuch der Schweiz 1912. 677 APPENDIX G Table 164 Table 165 Mortality from Cancer in^Bern Mortality from Cancer in Basel 1901- 1912 Rate per 100,000 Population Year 1901- 1912 Year Population Deaths from Cancer Population Deaths from Cancer Rate per 100,000 Population 1901 65,295 76 116.4 1901 110,310 90 81.6 1902 67,071 73 108.8 1902 112,672 103 91.4 1903 69,035 72 104.3 1903 115,351 101 87.6 1901. 71,037 66 92.9 1904 118,060 114 96.6 1905 72,671 80 110.1 106.3 1905 1901-1905 120,738 135 111.8 1901-1905 345,109 367 577,131 543 94.1 1906 74,499 89 119.5 1906 123,637 134 108.4 1907 76,174 77 101.1 1907 126,575 114 90.1 1908 77,604 87 112.1 1908 128,726 124 96.3 1909 82,284 83 100.9 1909 128,691 155 120.4 1910 84,755 96 113.3 109.3 1910 1906-1910 131,308 157 119.6 1906-1910 395,316 432 638,937 684 107.1 1911 85,780 75 87.4 1911 133,470 158 118.4 1912 86,900 105 120.8 1912 135,632 158 116.5 Source: Die Bewegung der ung in der Schweiz. Bevblker- Source: Die Bewegung der ung in der Schweiz. Bevolker- Table 166 Table 167 Mortality from Cancer in Geneva Mortality from Cancer in Zurich 1901- 1912 Rate per 100,000 Population Year 1901- 1912 Year Population Deaths from Cancer Population Deaths from Cancer Rate per 100,000 Population 1901 105,517 132 125.1 1901 150,377 160 106.4 1902 108,336 128 118.2 1902 151,797 168 110.7 1903 111,244 145 130.3 1903 155,964 175 112.2 1904 115,587 116 100.4 1904 161,100 179 111.1 1905 113,144 144 127.3 120.1 1905 1901-1905 166,126 190 114.4 1901-1905 553,828 665 785,364 872 111.0 1906 116,445 143 122.8 1906 170,683 188 110.1 1907 118,594 142 119.7 1907 175,149 196 111.9 1908 121,192 133 109.7 1908 178,831 186 104.0 1909 120,063 149 124.1 1909 183,650 221 120.3 1910 122,391 150 122.6 119.8 1910 1906-1910 189,065 197 104.2 1906-1910 598,685 717 897,378 988 110.1 1911 128,000 149 116.4 1911 194,480 203 104.4 1912 130,000 185 142.3 1912 199,000 246 123.6 Source: Die Bewegung der Bevcilkerung in der Schweiz. Source : Die Bewegung der Bevolkerung in der Schweiz. 678 APPENDIX G Table 168 Mortality from Cancer in Austria 1895-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1895 24,650,770 15,757 63.9 1906 27,355,419 21,391 78.2 1907 27,598,480 21,431 77.7 1896 24,898,222 16,410 65.9 1908 27,843,525 21,788 78.3 1897 25,153,390 17,109 68.0 1909 28,070,718 22,180 79.0 1898 25,397,725 17,667 69.6 1910 28,324,940 22,157 78.2 1899 25,655,952 17,961 70.0 1900 25,921,671 18,423 71.1 68.9 1906-1910 1911 139,193,082 28,516,220 108,947 23,585 78.3 1896-1900 127,026,960 87,570 82.7 1912 28,707,500 23,511 81.9 1901 26,178,756 19,154 73.2 1902 26,434,201 19,685 74.5 Source: Bewegung der Bevolkerung der 1903 26,668,312 19,728 74.0 im Reichsrate vertretenea Konicreiche 1904 26,916,299 20,231 75.2 und Laader. 1905 27,083,056 20,744 76.6 74.7 1901-1905 133,280,624 99,542 Table 169 Mortality from Cancer in Austria, by Sex 1901-1912 MALES FEMALES Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1901 12,749,054 8,722 68.4 1901 13,429,702 10,432 77.7 1902 12,873,456 8,974 69.7 1902 13,560,745 10,711 79.0 1903 12,984,801 8,932 68.8 1903 13,683,511 10,796 78.9 1904 13,105,546 9,099 69.4 1904 13,810,753 11,132 80.6 1905 13,186,740 9,446 71.6 69.6 1905 1901-190. 13,896,316 11,298 81.3 1901-1905 64,899,597 45,173 5 68,381,027 54,369 79.5 1906 13,316,618 9,834 73.8 1906 14,038,801 11,557 82.3 1907 13,434,940 9,846 73.3 1907 14,163,540 11,585 81.8 1908 13,554,228 10,139 74.8 1908 14,289,297 11,649 81.5 1909 13,662,018 10,340 75.7 1909 14,408,700 11,840 82.2 1910 13,787,028 10,242 50.401 74.3 74.4 1910 1906-191( 14,537,912 11,915 82.0 1906-1910 67,754,832 ) 71,438,250 58,546 82.0 1911 13,878,844 11,090 79.9 1911 14,637,376 12,495 85.4 1912 13,970,660 11,131 79.7 1912 14,736,840 12,380 84.0 Source Bewegung der Bevolkerung der im Reichsrate vertretenen K onigreiche und Lander. 679 APPENDIX G Table 170 Mortality from Cancer in Austria, by Provinces and Race 1907-1911 Province Population Lower Austria 17,272,023 Upper Austria 4,201,966 Salzburg 1,052,264 Styria 7,210,591 Carinthia 1,947,234 Tyrol 4,640,064 V'orarlberg 711,880 Silesia 3,709,688 Total German 40,745,710 Trieste Italian 1,110,874 Carniola 2,594,840 Goritz and Gradiska 1,276,793 Total Slovenic 3,871,633 Istria 1,968,684 Dalmatia 3,170,366 Total Serbo-Croatic 5,139,050 Bohemia 33,293,281 Moravia 12,891,685 Total Bohemian 46,184,966 Galicia 39,375,765 Bukowina 3,925,885 Total Polish-Ruthenian. . 43,301,650 Total for Austria 140,353,883 Source: Osterreichische Statistik: tenen Konigreiche und Lander. Deaths Rate per from 100,000 Cancer Population 20,632 119.5 Race Constitution, 1910 5,708 1,474 6,918 1,622 5,081 890 2,482 1,267 587 34,642 12,484 111,141 135.8 140.1 95.9 83.3 109.5 125.0 66.9 95.9% German 99.7% German 99.7% German 44,807 110.0 99.7% German 70.5% German, 29.4% Slovenic 78.6% German, 21.2% Slovenic 57.3% German, 42.1% Italian 95.4% German 43.9% German, 31.7% Polish, 24.3% Bohemian 1,103 99.3 62.3% Italian, 29.8% Slovenic 48.8 94.4% Slovenic 46.0 61.9% Slovenic, 36.1% Italian 47.9 42.6 43.5% Serbo-Croatic, 38.1% Ital- ian, 14.3% Slovenic 24.4 96.2% Serbo-Croatic 31.S 104.1 63.2% Bohemian, 36.8% German 71.8% Bohemian, 27.6% German 47,126 103.0 12,844 32.6 58.6% Polish, 40.2% Ruthenian 1,796 45.7 38.4% Ruthenian, 34.4% Ruma- 14,640 33.8 79.2 35.58% German, 60.65% Slavic, 3.73% Latin, 0.4% Magyar. Bewegung der Bevolkerung der im Reichsrate vertre- 680 APPENDIX G Table 171 Mortality from Malignant Tumors in Austrian Cities 1909-1910 City Population 1909 Vienna 3,993,125 2,220 Prague 443,051 202 Lemberg 402,978 188 Trieste 439,947 199 Krakau 291,760 128 Graz 300,822 248 Briinn 248,195 153 Source: Osterreichisches Stadtebuch. 14. Note: Non-residents are excluded. Deaths from Cancer Rate per 100,000 1910 1909-1910 Population 2,319 4,539 113.7 281 483 109.0 194 382 94.8 184 383 87.1 129 257 88.1 215 463 153.9 109 262 105.6 Band. Table 172 Mortality from Cancer in Vienna 1900-1912 Year Population Deaths from Cancer Rate per 100,000 Population 1900 1,662,124 1,915 115.2 1901 1902 1903 1904 1905 1,687,790 1,714,007 1,740,638 1,767,690 1,856,408 1,951 1,884 2,137 2,099 2,135 10,206 115.6 109.9 122.8 118.7 115.0 901-1905 8,766,533 116.4 1906 1907 1908 1909 1910 1,886,652 1,917,396 1,948,648 1,980,416 2,012,709 2,080 2,406 2,505 2,469 2,558 110.2 125.5 128.6 124.7 127.1 906-1910 9,745,821 12,018 123.3 1911 1912 2,045,002 2,077,295 2,680 2,759 131.1 132.8 Source : Bericht des Wiener Stadtphysi- kates. Bewegung der Bevolkerung der im Reichsrate vertretenen Konigreiche und Lander. Statistisches Jahrbuch der Stadt Wien. 681 APPENDIX G Table 173 Mortality from Cancer in Vienna, by Sex 1900-1912 MALES FEMALES Year 1900 Population 796,562 Deaths from Cancer 782 Rate per 100,000 Population 98.2 Year 1900 Population 865,562 Deaths from Cancer 1,133 Rate per 100,000 Population 130.9 1901 1902 1903 1904 1905 808,924 821,489 834,253 847,218 889,739 773 837 956 886 934 95.6 101.9 114.6 104.6 105.0 104.4 1901 1902 1903 1904 1905 1901-1905 878,866 892,518 906,385 920,472 966,669 1,178 1,047 1,181 1,213 1,201 134.0 117.3 130.3 131.8 124.2 1901-1905 4,201,623 4,386 4,564,910 5,820 127.5 1906 1907 1908 1909 1910 904,235 918,970 933,948 949,174 964,651 881 1,079 1,094 1,102 1,159 97.4 117.4 117.1 116.1 120.1 113.8 1906 1907 1908 1909 1910 1906-1910 982,417 998,426 1,014,700 1,031,242 1,048,058 1,199 1,327 1,411 1,367 1,399 122.0 132.9 139.1 132.6 133.5 1906-1910 4,670,978 5,315 5,074,843 6,703 132.1 1911 1912 980,128 995,605 1,194 1,301 121.8 130.7 1911 1912 1,064,874 1,081,690 1,486 1,458 139.5 134.8 Source: Bericht des Wiener Stadtphysi- kates. Statistisches Jahrbucli der Stadt Wien. Table 174 Mortality from Cancer among the Jewish Population of Vienna 1898-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1898 140,718 125 88.8 1906 163,962 196 119.5 1899 142,825 113 79.1 1907 166,801 341 204.4 1900 146,926 122 83.0 1908 169,640 311 183.3 1909 172,479 364 211.0 1901 1902 149,766 152,606 134 139 89.5 91.1 1910 175,318 250 142.6 1903 155,445 95 61.1 1906-1910 848,200 1,462 172.4 1904 158,284 156 98.6 1905 161,123 180 111.7 1911 178,157 240 134.7 1912 180,996 226 124 9 1901-1905 777,224 704 90.6 Source: Bericht des Vorstandes der Israelitischen Kultusgemeinde in Wien iiber seine Tatigkeit. (Biennial reports.) 682 APPENDIX G Table 175 Proportionate Mortality from Cancer among the Jewish Population of Vienna, by Sex, 1898-1912 MALES FEMALES Year Deaths from All Causes Deaths from Cancer Cancer in Per Cent, of All Causes , Year Deaths from All Causes Deaths from Cancer Cancer in Per Cent of All Causes 1898 996 69 6.9 1898 768 56 7.3 1899 1,058 66 6.2 1899 858 47 5.5 1900 1,027 63 6.1 1900 853 59 6.9 1901 1,053 63 6.0 1901 893 71 8.0 1902 1,111 72 6.5 1902 897 67 7.5 1903 1,011 42 4.2 1903 846 53 6.3 1904 1,065 83 7.8 1904 917 73 8.0 1905 1,131 92 352 8.1 6.6 1905 1901-1905 971 88 352 9.1 1901-1905 5,371 4,524 7.8 1906 1,136 101 8.9 1906 841 95 11.3 1907 1,089 174 16.0 1907 911 167 18.3 1908 1,148 150 13.1 1908 986 161 16.3 1909 1,248 197 15.8 1909 1,000 167 16.7 1910 1,195 119 741 10.0 12.7 1910 1906-1910 991 131 721 13.2 1906-1910 5,816 4,729 15.2 1911 1,249 112 9.0 1911 1,059 128 12.1 1912 1,264 124 9.8 1912 987 102 10.3 Source: Bericht des Vorstandes der Israelitischen Kultusgemeinde in Wien iiber seine Tatigkeit. (Biennial reports.) Table 176 Mortality from Cancer in Hungary 1897-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1897 18,554,494 5,388 29.0 1906 20,099,028 8,229 40.9 1898 18,738,579 5,458 29.1 1907 20,210,113 8,635 42.7 1899 18,927,595 5,267 27.8 1908 20,458,762 9,022 44.1 1900 19,144,142 7,021 36.7 1909 20,606,760 9,175 .44.5 1910 20,792,709 9,489 45.6 1897-1900 75,364,810 23,134 30.7 • 1906-1910 102,167,372 44,550 43.6 1901 19,342,190 6,941 35.9 1902 19,513,336 7,461 38.2 1911 20,980,265 9,718 46.3 1903 19,669,177 7,742 39.4 1912 21,168,000 9,970 47.1 1904 1905 19,831,663 19,869,296 8,112 8,110 40.9 40 8 Source: Ungarisches statistisches Jahr- 39.1 buch, 1897-1899. A Magyar szei orszagainak, 1900-1908 evi., Nepn Budapest. Ungarisches statistisches Jahrbi it korona 1901-1905 98,225,662 38,366 lozgalma. ich, 1909. Annuaire statistique Hongrois., 1910- 1912. 683 APPENDIX G Table 177 Mortality from Cancer in Hungary, by Sex 1897-1908 MALES Deaths Rate per Year Population from 100,000 Cancer Population 1897 9,232,716 2,276 24.7 1898 9,324,317 2,301 24.7 1899 1900 9,526,125 3,080 32.3 1901 9,620,805 3,135 32.6 1902 9,702,031 3,396 35.0 1903 9,775,581 3,428 35.1 1904 9,852,370 3,627 36.8 1905 9,867,092 3,521 35.7 1901-1905 48,817,879 17,107 35.0 1906 9,977,157 3,593 36.0 1907 10,028,258 3,803 37.9 1908 10,145,500 4,011 39.5 1906-1908 30,150,915 FEMALES 11,407 37.8 1897 9,321,778 3,112 33.4 1898 9,414,262 3,157 33.5 1899 1900 9,618,017 3,941 41.6 1901 9,721,385 3,806 39.2 1902 9,811,305 4,065 41.4 1903 9,893,596 4,314 43.6 1904 9,979,293 4,485 44.9 1905 10,002,204 4,589 45.9 1901-1905 49,407,783 21,259 43.0 1906 10,121,871 4,636 45.8 1907 10,181,855 4,832 47.5 1908 10,313,262 5,011 48.6 1906-1908 30,616,988 14,479 47.3 Source: Ungarisches statistisches Jahrbuch, 1897-1899. A Magj'ar szent korona orszagainak, 1900-1908 evi, Nepmoz- galma, Budapest. 684 APPENDIX G Table 178 Mortality from Cancer in Hungary, by Organs and Parts, aceording to Sex 1901-1904 MALES Organ or Pait Lips Tongue Mouth (Esophagus Stomach 6,098 Liver Pancreas Rectum Other intestines Peritoneum Larynx Kidney Bladder Thyroid gland Male generative organs Uterus Other female generative organs Breast Bones Skin Other organs Not specified Deaths Rate per from 100,000 Cancer Population 179 0.5 359 0.9 218 0.6 329 0.8 6,098 15.7 1,245 3.2 28 0.1 243 0.6 755 1.9 11 0.0 390 1.0 61 0.2 435 1.1 78 0.2 66 0.2 8 0.0 115 0.3 524 1.3 114 0.3 720 1.8 All organs 11,976 30.7 Source: Ungarische statistische Mitteilungen. Neue Serie, 19. Band Krebskranken in den Landern der Ungarischen heiligen Krone. FEMALES Deaths Rate per from 100,000 Cancer Population 28 0.1 37 0.1 46 0.1 57 0.1 5,116 13.0 1,318 3.3 13 0.0 209 0.5 912 2.3 49 0.1 75 0.2 68 0.2 108 0.3 16 0.0 4,596 11.7 96 0.2 934 2.4 42 0.1 343 0.9 128 0.3 745 2.0 14,936 37.9 and. Statistik der Table 179 Percentage Distribution of Cancer Cases in Hungary by Organs and Parts, according to Sex, 1904 MALES Organ or Part Lips Digestive system Urinary system Breast Generative system. . . Respiratory system. . . Nervous system Other glands Bones Skin of head and face. Skin of other parts . . . Cases Per Cent 415 30.12 542 39.33 14 1.02 6 0.44 35 2.54 27 1.96 1 0.07 13 0.94 44 3.19 243 17.63 38 2.76 All organs 1,378 100.00 Source: Ungarische statistische Mitteilungen. Neue Serie, 19. Band Krebskranken in den Landern der Ungarischen heiligen Krone. FEMALES Case" Per Cent. 39 1.79 333 15.28 11 0.50 496 22.76 972 44.61 6 0.28 0.00 10 0.46 21 0.96 245 11.24 46 2.11 2,179 100.00 nd. Statistik der 685 APPENDIX G Table 180 Mortality from Cancer in Hungary, by Race 1901-1904 Race Population Magyar 36,141,954 German 8,411,451 Rumanian 11,305,074 Slovak 7,996,899 Croatian 6,843,219 Serbian ; 4,247,087 Ruthenian 1,754,347 Others 1,656,335 Total 78,356,366 Source: Ungarische statistische Mitteilungen. Neue Serie, 19 Krebskranken in den Landern der Ungarischen heiligen Krone. Deaths Rate per from 100,000 Cancer Population 15,950 44.1 4,741 56.4 1,280 11.3 2,278 28.5 1,226 17.9 819 19.3 80 4.6 538 32.5 26,912 34.3 . Band. Statistik der Table 181 Mortality from Cancer in Budapest 1881-1912 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1881 377,393 221 58.6 1901 738,602 598 81.0 1882 390,646 253 64.8 1902 749,092 720 96.1 1883 403,899 294 72.8 1903 759,579 737 97.0 1884 417,152 277 66.4 1904 770,067 779 101.2 1885 430,405 248 57.6 64.0 1905 1901-1905 780,560 716 91.7 1881-1885 2,019,495 1,293 3,797,900 3,550 93.5 1886 443,658 303 68.3 1906 791,748 732 92.5 1887 456,911 332 72.7 1907 810,664 834 102.9 1888 470,164 314 66.8 1908 829,580 819 98.7 1889 483,417 313 64.7 1909 848,496 858 101.1 1890 496,670 327 65.8 67.6 1910 1906-1910 867,412 936 107.9 1886-1890 2,350,820 1,589 4,147,900 4,179 100.7 1891 517,616 449 86.7 1911 886,328 843 95.1 1892 540,079 477 88.3 1912 905,244 994 109.8 1893 1894 562,543 585,008 391 • 434 69.5 74.2 Source : Die Sterblichkeit der Stadt Bu- 1895 607,471 493 81.2 dapest. 1891-1895 2,812,717 2,244 79.8 Stadt Budapest. 1896 629,934 415 65.9 1897 652,397 483 74.0 1898 674,862 506 75.0 1899 697,325 533 76.4 1900 719,788 554 77.0 73.8 1896-1900 3,374,306 2,491 686 APPENDIX G Table 182 Mortality from Cancer in Budapest Males, 1881-1912 Table 183 Mortality from Cancer in Budapest Females, 1881-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 189,866 62 32.7 1881 187,527 159 84.8 1882 196,456 75 38.2 1882 194,190 178 91.7 1883 203,040 94 46.3 1883 200,859 200 99.6 1884 209,619 88 42.0 1884 207,533 189 91.1 1885 216,192 96 44.4 40.9 1885 1881-1885 214,213 152 71.0 1881-1885 1,015,173 415 1,004,322 878 87.4 1886 222,761 111 49.8 1886 220,897 192 86.9 1887 229,324 121 52.8 1887 227,587 211 92.7 1888 235,881 121 51.3 1888 234,283 193 82.4 1889 242,434 101 41.7 1889 240,983 212 88.0 1890 248,931 113 45.4 48.1 1890 1886-1890 247,739 214 86.4 1886-1890 1,179,331 567 1,171,489 1,022 87.2 1891 259,119 164' 63.3 1891 258,497 285 110.3 1892 269,985 181 67.0 1892 270,094 296 109.6 1893 280,878 127 45.2 1893 281,665 264 93.7 1894 291,685 139 47.7 1894 293,323 295 100.6 1895 302,460 190 62.8 57.0 1895 1891-1895 305,011 303 99.3 1891-1895 1,404,127 801 1,408,590 1,443 102.4 1896 313,266 150 47.9 1896 316,668 265 83.7 1897 323,980 172 53.1 1897 328,417 311 94.7 1898 334,664 199 59.5 1898 340,198 307 90.2 1899 345,385 194 56.2 1899 351,940 339 96.3 1900 356,079 201 56.4 54.7 1900 1896-1900 363,709 353 97.1 1896-1900 1,673,374 916 1,700,932 1,575 92.6 1901 365,165 256 70.1 1901 373,437 342 91.6 1902 370,126 275 74.3 1902 378,966 445 117.4 1903 375,156 308 82.1 1903 384,423 429 111.6 1904 380,182 327 86.0 1904 389,885 452 115.9 1905 385,206 302 78.4 78.3 1905 1901-1905 395,354 414 104.7 1901-1905 1,875,835 1,468 1,922,065 2,082 108.3 1906 390,569 301 77.1 1906 401,179 431 107.4 1907 399,738 319 79.8 1907 410,926 515 125.3 1908 408,900 338 82.7 1908 420,680 481 114.3 1909 418,054 337 80.6 1909 430,442 521 121.0 1910 427,200 442 103.5 85.0 1910 1906-1910 440,212 494 112.2 1906-1910 2,044,461 1,737 2,103,439 2,442 116.1 1911 436,346 .344 78.8 1911 449,982 499 110.9 1912 445,492 428 96.1 1912 459,752 566 123.1 Source: Die Sterblichkeit der Stadt Bu- Source: Die SterbUchkeit der Stadt Bu- dapest. dapest. Statistisch-Administratives Jahrbuch der Statistisch-Administratives Jahrbuch der Stadt Budapest. Stadt Budapest. 687 APPENDIX G Table 184 Mortality from Cancer in Budapest, by Religious Confession 1902-1906 NON-JEWISH MORTALITY Carcinoma Carcinoma Uteri Deaths Per Cent. Per Cent. Year from All Deaths of All Deaths of All Causes Causes Carcinoma 1902 12,332 702 5.69 162 23.1 1903 12,591 708 5.62 132 18.6 1904 12,821 817 6.37 157 19.2 1905 13,471 714 5.30 127 17.8 1906 13,880 602 4.34 137 22.8 1902-1906 65,095 3,543 5.44 715 20.2 JEWISH MORTALITY 1902 2,400 167 6.96 10 6.0 1903 2,468 188 7.62 18 9.6 1904 2,614 192 7.35 13 6.8 1905 2,623 153 5.83 15 9.8 1906 2,500 183 7.32 12 6.6 1902-1906 12,605 883 7.01 68 7.7 Source: F. Theilhaber: Sociale Stellung und Rasse bei Uteruscarcinom. In: Zeit- schrift fiir Krebsforschung, 8. Band. Table 185 Mortality from Cancer in Italy 1887-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1887 29,614,430 12,631 42.7 1901 32,533,337 17,141 52.7 1888 29,825,022 12,625 42.3 1902 32,699,510 17,634 53.9 1889 30,035,038 12,923 43.0 1903 32,839,509 17,774 54.1 1890 30,245,054 12,917 42.7 1904 33,016,234 18,860 57.1 1905 33,193,289 19,348 58.3 1887-1890 119,719,544 51,096 42.7 1901-1905 164,281,879 90,757 55.2 1891 30,455,070 13,094 43.0 1892 30,665,662 13,069 42.6 1906 33,325,098 20,653 62.0 1893 30,875,678 13,234 42.9 1907 33,514,702 20,668 61.7 1894 31,085,694 13,841 44.5 1908 33,826,688 21,828 64.5 1895 31,295,710 15,089 48.2 1909 34,077,068 34,376,609 21,871 22,555 64.2 65.6 1910 18Q1-189'i 154,377,814 31,506,302 68,327 15,482 44 3 1896 49.1 1906-1910 169,120,165 107,575 63.6 1897 31,716,318 15,967 50.3 1911 34,688,814 23,172 66.8 1898 31,926,334 16,330 51.1 1912 35,026,486 22,661 64.7 1899 32,136,350 16,680 51.9 1900 32,340,366 16,873 52.2 50.9 Source: Statistica dalle Cause di Morte. 1896-1900 159,631,670 81,332 688 APPENDIX G Table 186 Mortality from Cancer in Italy, Males 1896-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1896 15,674,385 6,598 42.1 1906 16,462,598 8,929 54.2 1897 15,778,868 6,634 42.0 1907 16,522,748 9,085 55.0 1898 15,883,351 6,843 43.1 1908 16,606,874 9,747 58.7 1899 15,987,834 6,980 43.7 1909 16,731,840 9,603 57.4 1900 16,092,317 7,190 44.7 43.1 1910 1906-1910 16,844,538 9,818 58.3 1896-1900 79,416,755 34,245 83,168,598 47,182 56.7 1901 16,185,335 7,399 45.7 1911 17,030,126 10,137 59.5 1902 16,251,656 7,571 46.6 1912 17,195,903 10,070 58.6 1903 16,304,816 7,673 47.1 1904 16,376,052 8,271 50.5 Source: Statistica delle Cause di Morte. 1905 16,430,678 8.417 51.2 48.2 1901-1905 81,548,537 39,331 Table 187 Mortality from Cancer in Italy, Females 1896-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1896 15,831,917 8,884 56.1 1906 16,862,500 11,724 69.5 1897 15,937,450 9,333 58.6 1907 16,991,954 11,583 68.2 1898 16,042,983 9,487 59.1 1908 17,219,814 12,081 70.2 1899 16,148,516 9,700 60.1 1909 17,345,228 12,268 70.7 1900 16,254,049 9,683 59.6 58.7 1910 1906-1910 17,532,071 12,737 72.6 1896-1900 80,214,915 47,087 85,951,567 60,393 70.3 1901 16,348,002 9,742 59.6 1911 17,658,688 13,035 73.8 1902 16,447,854 10,063 61.2 1912 17,830,583 12,591 70.6 1903 16,534,693 10,101 61.1 1904 16,640,182 10,589 63.6 Source: Statistica delle Cause di Morte. 1905 16,762,611 10,931 65.2 62.2 1901-1905 82,733,342 51,426 689 APPENDIX G Table 188 Mortality from Cancer in Italy, by Provinces 1906-1910 Province Population Piemonte 16,700,015 Liguria 5,838,536 Lombardia 23,400,341 Veneto 17,201,497 Northern Italy 63,140,389 Emilia 13,075,413 Toscana 13,141,273 Marche 5,331,467 Umbria 3,348,323 Roma 6,351,526 Central Italy 41,248,002 Abruzzi 6,977,124 Campania 16,151,582 Puglie 10,388,107 Bassilicata 2,311,658 Calabrie 6,837,870 Sicilia 17,908,500 Sardegna 4,156,933 Southern Italy 64,731,774 All Italy 169,120,165 Source: Statistica delle Cause di Morte neU'amio 1906-1910. Deaths Rate per from 100,000 Cancer Population 11,775 70.5 4,396 75.3 18,987 81.1 11,116 64.6 46,274 73.3 12,118 92.7 12,557 95.6 3,729 69.9 1,973 58.9 4,100 64.6 34,477 83.6 3,244 46.5 7,363 45.6 4,031 38.8 946 40.9 2,541 37.2 7,354 41.1 1,345 32.4 26,824 41.4 107,575 63.6 Table 189 Mortality from Cancer in Italy, by Organs and Parts 1891-1910 Deaths fbom Cancer 1891- 1896- 1901- 1906- Organ or Part 1895 1900 1905 1910 Bones and joints 306 982 1,998 1,375 Mouth, lips, tongue, palate, thyroid, larynx, trachea. 2,491 4,777 5,587 4,820 Stomach and oesophagus. . 19,577 22,756 26,237 33,089 Liver, spleen, pancreas, in- testines and peritoneum 11,569 15,545 18,256 21,700 Ner^-ous system 309 587 448 2,071 Bladder, urethra, prostate, penis and testicle 1,320 1,502 1,800 2,239 Breast 4,372 4,590 4,592 5,103 Uterus, vagina and ovary.. 11,654 12,548 12,700 13,741 Not specified 16,729 18,045 19,139 23,437 All organs 68.327 81,332 90,757 107,575 Source: Statistica delle Cause di Morte, 1891-1910. Rate peb 100,000 Popui^atiojj 1891- 1896- 1901- 1906- 1895 1900 1905 1910 0.20 0.62 1.22 0.81 1.61 2.99 3.40 2.85 12.68 14.26 15.97 19.57 7.49 9.74 11.11 12.83 0.20 0.37 0.27 1.22 0.86 0.94 1.10 1.32 2.83 2.88 2.79 3.02 7.55 7.86 7.73 8.13 10.84 11.30 11.65 13.86 44.26 50.95 55.24 63.62 690 APPENDIX G Table 190 Mortality from Cancer in Rome, 1898-1912 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1898 438,417 347 79.1 1906 502,453 429 85.4 1899 446,539 350 78.4 1907 510,387 494 96.8 1900 454,661 380 83.6 1908 518,321 493 95.1 1909 526,255 534 101.5 1901 462,783 355 76.7 1910 534,189 530 99.2 1902 470,717 425 90.3 1903 478,651 429 89.6 1906-1910 2,591,605 2,480 95.7 1904 1905 486,585 494,519 456 455 93.7 92.0 1911 1912 542,123 550,057 574 .548 105.9 99.6 1901-1905 2,393,255 2,120 88.6 Source : Statistica delle Cause di Morte, Roma. Table 191 Mortality from Cancer in Naples 1898-1912 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1898 554,154 342 61.7 1906 620,786 464 74.7 1899 557,616 318 57.0 1907 632,235 417 66.0 1900 560,078 364 65.0 1908 643,684 453 70.4 1909 655,133 418 63.8 1901 563,540 351 62.3 1910 666,582 411 61.7 1902 574,990 375 65.2 1903 586,439 369 62.9 1906-1910 3,218,420 2,163 67.2 1904 1905 597,888 609,337 401 336 67.1 55.1 1911 1912 678,031 689,480 463 423 68.3 61.4 1901-1905 2,932,194 1,832 62.5 Source: Statistica delle Cause di Morte, Roma. Table 192 •• Mortality from Cancer in Genoa 1898- 1912 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1898 226,430 229 101.1 1906 253,466 293 115.6 1899 229,190 200 87.3 1907 257,217 281 109.2 1900 231,950 218 94.0 1908 260,968 273 104.6 1909 264,719 286 108.0 1901 234,710 227 96.7 1910 268,470 271 100.9 1902 238,462 216 90.6 1903 242,213 255 105.3 1906-1910 1,304,840 1.404 107.6 1904 1905 245,964 249.715 240 220 97.6 88.1 1911 1912 272,221 275,972 285 278 104.7 100.7 1901-1905 1,211,064 1,158 95.6 Source: Statistica delle Cause di Morte, Roma. 691 APPENDIX G Table 193 Mortality from Cancer in Turin, 1898-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1898 323,356 334 103.3 1906 381,381 398 104.4 1899 327,456 312 95.3 1907 390,526 425 108.8 1900 331,556 343 103.5 1908 399,671 489 122.4 1909 408,816 471 115.2 1901 335,656 364 108.4 1910 417,961 432 103.4 1902 344,801 365 105.9 1903 353,946 347 98.0 1906-1910 1,998,355 2,215 110.8 1904 363,091 397 109.3 1905 372,236 378 101.5 1911 427,106 462 108.2 1912 436,251 487 111.6 1901-1905 1,769,730 1,851 104.6 Source: Statistica delle Cause di Morte, Roma. Table 194 Mortality from Cancer in Milan 1898-1912 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1898 466,027 459 98.5 1906 545,330 658 120.7 1899 474,508 486 102.4 1907 556,104 635 114.2 1900 482,989 483 100.0 1908 566,878 640 112.9 1909 577,652 688 119.1 1901 491,460 466 94.8 1910 588,426 686 116.6 1902 502,234 520 103.5 1903 513,008 513 100.0 1906-1910 2,834,390 3,307 116.7 1904 1905 523,782 534,556 588 606 112.3 113.4 1911 1912 599,200 609,974 812 736 135.5 120.7 1901-1905 2,565,040 2,693 105.0 Source: Statistica delle Cause di Morte, Roma. Table 195 Mortality from Cancer in Florence 1898-1912 Year 1898 1899 1900 1901 1902 1903 1904 1905 Population 201,677 202,981 204,285 205,589 208,317 211,044 213,771 216,498 Deaths from Cancer 301 278 313 287 327 292 293 340 Rate per 100,000 Population 149.2 137.0 153.2 139.6 157.0 138.4 137.1 157.0 145.8 Year 1906 1907 1908 1909 1910 1906-1910 1911 1912 Source: Roma. Population 219,225 221,952 224,679 227,406 230,133 Deaths from Cancer 345 343 393 393 351 Rate per 100,000 Population 157.4 154.5 174.9 172.8 152.5 1,123,395 1,825 232,860 335 235,587 389 Statistica delle Cause 162.5 143.9 165.1 1901-1905 1,055,219 1,539 di Morte, APPENDIX G Table 196 Mortality from Cancer in Palermo, 1898-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1898 299,989 128 42.7 1906 325,393 159 48.9 1899 303,224 125 41.2 1907 328,532 149 45.4 1900 306,459 140 45.7 1908 331,671 166 50.0 1909 334,810 196 58.5 1901 309,694 129 41.7 1910 337,949 177 52.4 1902 312,837 133 42.5 1903 315,976 138 43.7 1906-1910 1,658,355 847 51.1 1904 319,115 125 39.2 1905 322,254 150 46.5 1911 341,088 192 56.3 1912 344,227 161 46.8 1901-1905 1,579,876 675 42.7 Source: Statistica dell e Cause di Morte, Roma. Table 197 Mortality from Cancer in Spain, 1900-1912 Year Population Death from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1900 1901 1902 1903 1904 1905 18,566,200 18,657,000 18,755,000 18,853,000 18,951,000 19,049,000 7,294 7,912 8,117 8,315 8,825 8,719 39.3 42.4 43.3 44.1 46.6 45.8 44.4 1906 1907 1908 1909 1910 1906-1910 1911 1912 19,147,000 19,245,000 19,343,000 19,442,000 19,540,000 9,113 9,141 9,947 9,914 10,093 47.6 47.5 51.4 51.0 51.7 96,717,000 19,640,000 19,740,000 48,208 10,282 10,899 49.8 1901-1905 94,265,000 41,888 52.4 55.5 Source : Annual Report of the Registrar- General of Births, Deaths and Marriages in England and Wales, 1912. Table 198 Mortality from Cancer in Spain, by Organs and Parts Urban and Rural Districts, 1900 ClTIE3 Organ or Part Buccal cavity Stomach and liver Peritoneum, intestines and rectum. Female generative organs Breast Other or not specified organs Deaths from Cancer 158 413 111 436 49 738 Rate per 100,000 Population 5.2 13.6 3.7 14.3 1.6 24.3 Rural Distbicts Deaths Rate per from 100,000 Cancer Population 548 3.5 1,797 11.5 359 2.3 654 4.2 183 1.2 1,848 11.9 5,389 34.0 All organs 1,905 62.7 Population: Cities, 3,039,055, Rural Districts, 15,568,619. Source: Dr. Hans Leyden. Bericht iiber die am 1. September 1902 in Spanien veranstaltete Krebssammelforschung. In: Zeitschrif t f iir Krebsforschung, 1. Band, 1904. 693 APPENDIX G Table 198a Mortality from Cancer in Spain, by Organs and Parts, according to Sex 1901-1905 Organ or Part Buccal cavity Stomach and liver Peritoneum, intestines, rectum. Female generative organs Breast Skin Other or not specified organs . . AH organs. 18,480 40. Males Females Deaths Rate per Deaths Rate per from 100,000 from 100,000 Cancer Population Cancer Population 1,189 2.6 286 0.6 7,719 16.9 5,809 12.0 974 2.1 1,221 2.5 6,100 12.6 1,548 3.2 1,053 2.3 817 1.7 7,545 16.5 7,633 15.7 23,414 48.2 Source: La Geografia Medica de la Peninsula Iberica por el Dr. Ph. Hauser. Madrid, 1913. Table 199 Table 200 Mortality from Cancer in the City Mortality from Cancer in Portugal of Madrid, 19 01-1910 Deaths Rate per 1902-1910 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1901 543,005 425 78.3 1902 5,520,378 1,252 22.7 1902 546,175 474 86.8 1903 5,569,001 1,306 23.5 1903 549,345 500 91.0 1904 5,617,624 1,320 23.5 1904 552,515 491 88.9 1905 5,666,247 1,261 22.3 1905 555,685 505 90.9 1902-1905 22,373,250 5,139 23.0 1901-1905 2,746,725 2,395 87.2 1906 5,714,870 1,284 22.5 1906 558,855 500 89.5 1907 5,763,493 1,246 21.6 1907 562,026 524 93.2 1908 5,812,116 1,304 22.4 1908 565,197 555 98.2 1909 5,860,739 1,324 22.6 1909 568,368 559 98.4 1910 5,909,362 1,346 22.8 1910 571,539 535 93.6 6,504 22.4 1906-1910 2,825,985 2,673 94.6 Source: Annuario Estatistico de Portu- Source: Ayuntamiento de Madrid. gal, 1902-1905. Estadistica Demografica 1901-1910. Letter from Institute Central de Higiene, Lisboa. Note: Includes Madeira and the Azores. 694 APPENDIX G Table 201 Mortality from Cancer in Portugal, by Sex 1902-1910 MALES FEMALES Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1902 2,619,971 547 20.9 1902 2,900,407 705 24.3 1903 2,643,048 527 19.9 1903 2,925,953 779 26.6 1904 2,666,124 553 20.7 1904 2,951,500 767 26.0 1905 2,689,201 525 19.5 20.3 1905 1902-1905 2,977,046 736 24.7 1902-1905 10,618,344 2,152 11,754,906 2,987 25.4 1906 2,711,706 493 18.2 1906 3,003,164 791 26.3 1907 2,734,777 526 19.2 1907 3,028,716 720 23.8 1908 2,757,849 573 20.8 1908 3,054,267 731 23.9 1909 2,780,921 548 19.7 1909 3,079,818 776 25.2 1910 2,803,992 575 20.5 19.7 1910 1906-1910 3,105,370 771 24.8 1906-1910 13,789,245 2,715 15,271,335 3,789 24.8 Source: Annuario Estatistico de Portu- gal, 1902-1905. Letter from Institute Central de Higiene, Lisboa. Note : Includes Madeira and the Azores. Table 202 Mortality from Cancer in Portugal by Provinces, 1906-1910 Province Population Entre Minho-e-Douro 6,286,343 Tras-os-Montes 2,174,830 Beira 7,981,530 Estremadura 6,910,930 Alemtejo 2,307,725 Algarve 1,344,795 Azores 1,231,717 Madeira '. 822,710 Total 29,060,580 Source: Letter from Instituto Central de Higiene, Lisboa. Deaths Rate per from 100,000 Cancer Population 1,222 19.4 164 7.5 890 11.2 2,666 38.6 489 21.2 236 17.5 427 34.7 410 49.8 6,504 22.4 695 APPENDIX Q Table 203 Cancer Census of Portugal, by Organs and Parts 1904 Number op Cases Percentage Organ or Fart Total Males Females Total Males Females Skin 224 100 124 18.9 22.4 16.7 Lips 149 129 20 12.5 28.9 2.7 Tongue Stomach 29 104 23 70 6 34 2.4 8.8 5.1 15.7 0.8 4.6 Other digestive organs Male generative organs Breast 68 43 305 42 43 26 305 5.7 3.6 25.7 9.4 9.6 3.5 41.2 Uterus 159 159 13.4 21.5 Other female generative organs Other organs Not specified 26 74 7 38 2 447 26 36 5 741 2.2 6.2 0.6 8.5 0.4 100.0 3.5 4.8 0.7 1,188 100.0 100.0 Source: Dr. Azevedo Neves: Bericht iiber die Zahlung der im Mai und Juni 1904 in Portugal in arztlicher Behandlung gewesenen Krebskranken. In: Zeitschrift fiir Krebsforschung, 7. Band. Note: Of 1,739 physicians, 1,307 made reply to the circular of inquiry. Table 204 Mortality from Cancer in Porto 1893-1910 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1893 147,590 88 59.6 1906 180,938 104 57.4 1894 150,500 88 58.5 1907 183,352 119 64.9 1895 153,410 119 77.6 1908 185,766 101 54.4 1909 188,180 118 62.7 1896 1897 156,319 159,228 96 77 61.4 48.4 1910 190,594 141 74.0 1898 162,137 119 73.4 1906-1910 928,830 583 62.8 1899 164,040 97 59.1 1900 166,454 96 57.7 Source: Annuario Estatistico de Portu- gal, -1902-1905. Zeitschrift fiir Krebs 1896-1900 808,178 485 60.0 forschung 7. Band. Letter from Institute Central de Higiene, 1901 168,868 100 59.2 Lisboa. 1902 171,282 97 56.6 1903 173,696 106 61.0 1904 176,110 109 61.9 1905 178,524 126 ' 538 70.6 61.9 1901-1905 868,480 APPENDIX G Table 205 Table 206 Mortality from Cancer in Lisbon Mortality from Cancer in Moscow 1902-19 10 Deaths Rate per by Sex, 1892-1910 TOTAL Year Population from Cancer 100,000 Population Average No. Averai?e of Deaths Rate per 100,000 1902 367,430 294 80.0 Years Population from Cancer Population 1903 374,644 277 73.9 1892-1896 960,000 763 79.5 1904 381,858 312 81.7 1897-1901 1,098,000 861 78.4 1905 389,072 268 68.9 1902-1905 1906-1910 1,251,000 1,410,000 994 1,161 79.5 82.3 1902-1905 1,513,004 1,151 76.1 RLVLES 1906 396,286 308 77.7 1892-1896 550,000 3ie 57.5 1907 403,500 309 76.6 1897-1901 624,000 361 57.9 1908 410,714 350 85.2 1902-1905 702,000 453 64.5 1909 417,928 365 87.3 1906-1910 785,000 530 67.5 1910 425,142 350 82.3 81.9 1892-1896 FEMALES 410,000 447 1900-1910 2,053,570 1,682 109.0 1897-1901 474,000 500 105.5 Source: Annuario Estatistico de Por- 1902-1905 549,000 541 98.5 tugal. 1906-1910 625,000 631 101.0 Letter from Institute Central de Higiene, Lisboa. Source : Annuaire Statistique de la ville de Moscou Deuxieme Annee, 1907-1908. Table 207 Table 208 Mortality from Cancer in Moscow Mortality from Cancer in Petrograd 1910-19 12 Deaths Rate per 1911-19] 12 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1910 1,514,595 1,415 93.4 1911 1,935,430 1,607 83.0 1911 1,566,164 1,478 94.4 1912 1,990,874 1,753 88.1 1912 1,617,733 1,559 96.4 1911-1912 3,926,304 3,360 85.6 1910-1912 4,698,492 4,452 94.8 Source: Releve succint des donnees Source: Bulletin recapitulatif de la \'ille statistiques sur la ville de Petrograd pour de Moscou public par le Bureau de la les annees 1911 et 1912. Statistique Municipale. Annee, 1912. Note: With suburbs ; includes only carcinoma. 697 APPENDIX G Table 208a Mortality from Cancer in the City of Warsaw, 1881-1912 Year 1881 1882 1883 1884 1885 Population 379,763 382,964 391,491 404,889 406,965 1886 1887 1888 1889 1890 431,864 439,174 444,814 445,770 455,852 1886-1890 2,217,474 1891 1892 1893 1894 1895 465,272 490,417 501,021 515,654 535,968 1896 1897 1898 1899 1900 553,643 638,209 654,942 671,675 688,408 1901 1902 1903 1904 1905 705,141 721,874 736,607 755,340 772,074 1906 1907 1908 1909 1910 783,808 805,542 822,276 839,010 855,744 1911 872,478 1912 889,222 Deaths from Cancer 153 232 221 276 268 1881-1885 1,966,072 1,150 260 308 247 292 281 1,388 313 370 318 332 366 1891-1895 2,508,332 1,699 407 424 443 417 466 1896-1900 3,206,877 2,157 464 523 560 483 532 1901-1905 3,691,036 2,562 500 548 571 575 547 1906-1910 4,106,380 2,741 649 643 Rate per 100,000 Population 40.3 60.6 56.5 68.2 65.9 58.5 60.2 70.1 55.5 65.5 61.6 62.6 67.3 75.4 63.5 64.4 68.3 67.7 73.5 66.4 67.6 62.1 67.7 67.3 65.8 72.5 76.0 63.9 68.9 69.4 63.8 68.0 69.4 68.5 63.9 66.7 74.4 72.3 Source: Statistique Demographique des Grandes Villes du Monde pendant les annees 1880-1909. Amsterdam, 1911. 1910- 1912, Reports of the Highest Medical In- spector for Russia. Table 209 Mortality from Cancer in Serbia 1892-1912 Year 1892 1893 1894 1895 Population 2,211,606 2,240,270 2,272,992 2,312,484 1892-1895 9,037,352 1896 1897 1898 1899 1900 2,345,837 2,384,205 2,413,694 2,450,392 2,492,882 1896-1900 12,087,010 1901 1902 1903 1904 1905 2,535,956 2,576,517 2,621,576 2,671,505 2,688,747 Deaths from Cancer 121 140 156 128 545 154 167 178 233 235 967 230 248 238 275 279 1901-1905 13,094,301 1,270 1906 1907 1908 1909 1910 2,735,147 2,784,036 2,821,015 2,847,891 2,911,701 371 355 374 373 1906-1910 14,099,790 1,763 1911 1912 2,960,000 3,002,000 394 375 Rate per 100,000 Population 5.5 6.2 6.9 5.5 6.0 6.6 7.0 7.4 9.5 9.4 8.0 9.1 9.6 9.1 10.3 10.4 9.7 10.6 13.3 12.6 13.1 12.8 12.5 13.3 12.5 Source: Annuaire statistique du roy- aume de Serbie, 1896-1906. Original data furnished by the Statistical OflSce of Serbia. 698 APPENDIX G Table 210 Table 211 Mortalit y from Cancer in the Cities Mortality from Cancer in Twelve of Serbia, 1907 -1912 eaths Rate per Citii 2S of Greece, 1900- Deaths 1908 D Rate per Year Population f rom 100,000 Year Population from 100,000 c ancer Population Cancer Population 1907 426,300 159 37.3 1900 391,158 143 36.6 1908 437,000 149 34.1 1909 447,700 173 38.6 1901 396,554 179 45.1 1910 458,400 172 37.5 1902 401,950 176 43.8 1911 469,100 168 35.8 1903 407,346 210 51.6 1912 479,800 156 32.5 1904 412,742 185 44.8 1905 418,138 207 49.5 1907-1912 2,718,300 977 35.9 1901-1905 2,036,730 957 47.0 Source: Letter from the Statistical Office of Serbia. 1906 423,534 228 53.8 1907 428,930 228 53.2 1908 434,326 252 58.0 Source: Bulletin annuel des deces de 12 villesde Grece, 1900-1908 Table 212 Cases of Cancer in Twelve Cities of Greece, by Organs and Parts according to Sex, 1905-1908 NtTMBER OP Cases Percentage Organ or Part Total Males Females Total Males Females Skin 65 49 16 9.8 14.3 5.0 Lips 53 39 14 8.0 11.4 4.4 Tongue 41 31 10 6.2 9.1 3.2 Thyroid gland Brain 1 1 1 1 0.2 0.2 0.3 0.3 Larynx Branchiae 9 1 9 1 1.4 0.2 2.6 0.3 Lungs (Esophagus Stomach 1 8 159 1 8 117 42 0.2 1.2 24.1 0.3 2.3 34.2 13.2 Intestines 33 28 5 5.0 8.2 1.6 Pancreas 22 18 4 3.3 5.3 1.3 Liver 14 13 1 2.1 3.8 0.3 Peritoneum 1 1 0.2 0.3 Kidney Bladder 7 18 6 18 1 1.1 2.7 1.7 5.3 0.3 Breast 79 79 12.0 24.8 Penis 1 i 0.2 0.3 Uterus 112 112 17.0 35.2 Ovaries 9 9 1.4 2.8 Vagina 25 25 3.8 7.9 660 342 318 100.0 100.0 100.0 All specified organs. . . . Source: Dr. S. A. Gavales: Die Verbreitung der Krebskrankheit in Griechenland. In: Zeitschrift fiir Krebsforschung, 7. Band. 699 APPENDIX G Table 213 Mortality from Cancer in Athens, by Sex 1900-1908 TOTAL JIALES Year 1900 Population 138,570 Deaths from Cancer 68 Rate per 100,000 Population 49.1 Year 1900 Population 74,232 Deaths from Cancer 32 Rate per 100,000 Population 43.1 1901 1902 1903 1904 1905 142,700 146,830 150,960 155,090 159,220 76 75 88 103 108 450 53.3 51.1 58.3 66.4 67.8 59.6 1901 1902 1903 1904 1905 1901-1905 76,444 78,657 80,869 83,082 85,294 35 46 48 53 57 239 45.8 58.5 59.4 63.8 66.8 1901-1905 754,800 404,346 59.1 1906 1907 1908 163,350 167,480 171,610 109 107 116 66.7 63.9 67.6 1906 1907 1908 87,507 89,719 91,931 58 48 55 66.3 53.5 69.8 FEMALES Year 1900 Population 64,338 Deaths from Cancer 36 Rate per 100,000 Population 56.0 1901 1902 1903 1904 1905 66,256 68,173 70,091 72,008 73,926 41 29 40 50 51 211 61.9 42.5 57.1 69.4 69.0 1901-1905 350,454 60.2 1906 1907 1908 75,843 77,761 79,679 51 59 61 67.2 75.9 76.6 Source: Bulletin annuel des deces de 12 villes de Grece. 700 APPENDIX G Table 214 Mortality from Cancer in the Cities of Roumania 1901-1912 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1901 1902 1903 1,156,636 1,172,318 1,188,000 749 748 833 64.8 63.8 70.1 66.3 1906 1907 1908 1909 1910 1906-1910 1,235,046 1,250,728 1,266,409 1,282,090 1,297,771 788 709 818 765 835 63.8 56.7 64.6 59.7 64.3 1901-1903 3,516,954 2,330 6,332,044 3,915 61.8 1911 1912 1,313,452 1,329,133 813 938 61.9 70.6 Source: Anuarul Statistic al Romaniei, 1912. Annual Report of the Registrar-Gen- eral of Births, Marriages and Deaths in England and Wales, 1912. Table 215 Mortality from Cancer in Constantinople 1908-1912 Deaths Rate per Year Population from 100,000 Cancer Population 1908 1,100,000 370 33.6 1909 1,125,000 391 34.8 1910 1,150,000 437 38.0 1911 1,175,000 429. 36.5 1912 1,200,000 374 31.2 1908-1912 5,750,000 2,001 34.8 Source: Statistique Sanitaire de la ville de Constantinople. Annees 1324 a 1328. Table 216 Mortality from Cancer in Constantinople, by Religion 1908-1912 Deaths Rate per Total from 100,000 Population Cancer Population Mohammedans 3,460,000 782 22.6 Greeks 1,174,000 659 56.1 Armenians 532,000 294 65.3 Jews 278,000 123 44.2 Others 306,000 143 46.7 Total 5,750,000 2.001 S4.8 Source: Statistique Sanitaire de la ville de Constantinople. Annees 1324 a 1328. 701 APPENDIX G Table 217 Mortality from Cancer in Countries of Africa Deaths Rate per Population from 100,000 Cancer Population Algeria 3,688,433 1,257 34.1 Cape Colony 1,898,895 1,067 56.2 Mauritius 1,843,819 171 9.3 Natal 1,111,756 366 32.9 Sierra Leone 68,218 9 13.2 Transvaal 430,745 148 34.4 Total 9,041,866 3,018 33.4 Population, 1911: 1,959,645. Note: The data are given for Algeria, 1908-1912, Europeans only; for Cape Colony, 1904-1908, twenty-five cities and towns; for Mauritius, 1906-1910; for Natal, 1908-1912, Europeans and East Indians; for Sierra Leone, 1910-1911, City of Freetown only; for Transvaal, 1909-1911, Johannesburg only. Table 218 Mortality from Cancer in Algeria European Population, 1904-1912 Year Population Deaths from Cancer Rate per 100,000 Population 1904 1905 664,674 672,467 196 247 29.5 36.7 1906 1907 1908 1909 1910 680,259 694,616 708,973 723,330 737,687 227 170 196 188 239 33.4 24.5 27.6 26.0 32.4 06-1910 3,544,865 1,020 28.8 1911 1912 752,043 766,400 279 355 37.1 46.3 Source: Statistique generale de I'Algerie. 702 APPENDIX G Table 219 Mortality from Cancer in Mauritius, 1898-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1898 368,665 29 7.9 1906 368,745 35 9.5 1899 368,675 50 13.6 1907 368,755 29 7.9 1900 368,685 44 11.9 1908 368,764 36 9.8 1909 368,773 44 11.9 1901 368,695 62 16.8 1910 368,782 27 7.3 1902 368,705 59 16.0 1903 368,715 50 13.6 1906-1910 1,843,819 171 9.3 1904 368,725 42 11.4 1905 368,735 52 14.1 1911 368,791 50 13.6 1912 368,800 Colony of 36 9 8 1901-1905 1,843,575 265 14.4 Source: Mauritius , Annual Reports of the Registrar-General < an Births, Deaths and Marriages. Table 220 Mortality from Cancer in Mauritius Cases Treated in Public Hospitals 1898-1908 Fatality Fatality Year Cases Deaths Per Cent. Year Cases Deaths Per Cent. 1898 22 5 22.7 1906 68 9 13.2 1899 46 8 17.4 1907 57 10 17.5 1900 41 11 26.8 1908 57 11 19.3 1901 60 18 30.0 1902 47 5 10.6 Source: Colony of Mauritius, Annual 1903 64 20 31.3 Reports on the Medical and Health Depart- 1904 50 11 22.0 ment. 1905 83 11 13.3 Table 221 Mortality from Cancer in the Union of South Africa, by Organs and Parts according to Sex, White 1912 Males Organ or Part Buccal cavity Stomach and liver Peritoneum, intestines, rectum. , Female generative organs Breast Skin Other or not specified organs . . . All organs 188 Deaths from Cancer Rate per 100,000 Population 19 90 18 4.8 22.7 4.6 2 59 0.5 14.9 47.5 Females Deaths Rate per from 100,000 Cancer Population 1 0.3 32 9.8 14 4..S 28 8.6 19 5.8 4 1.2 26 8.0 124 38.0 Source: Statistical Year-Book of the Union of South Africa, 1913. Note: The data include Natal, Transvaal and Orange Free State only. 703 APPENDIX G Table 222 Mortality from Cancer in the Union of South Africa by Provinces, White 1912 Deaths Rate per White from 100,000 Population Cancer Population NataJ 98,294 61 62.1 Transvaal 442,577 175 39.5 Orange Free State 180,994 76 42.0 Total 721,865 312 43.2 Source: Statistical Year-Book of the Union of South Africa, 1913. Table 223 Mortality from Cancer in Cape Colony, South Africa Twenty-five Cities and Towns 1900-1908 Deaths Rate per Deaths Rate per Year Population from Cancer 100,000 Population Year Population from 100,000 Cancer Population 1900 334,441 200 59.8 1906 1907 379,779 376,532 236 62.1 186 49.4 1901 347,399 190 54.7 1908 373,285 228 61.1 1902 360,357 218 60.5 1903 373,315 185 49.6 Source: Vital Statistics of South Africa, 1904 386,273 193 50.0 1900-1905. Health Reports of South Africa, 1905 383,026 224 58.5 54.6 1906-1908. 1901-1905 1,850,370 1,010 Table 224 Mortality from Cancer in Johannesburg, South Africa, by Race 1909-1911 Race Population European 219,530 Asiatic 10,754 Native Black 200,461 Total 430,745 Deaths from Cancer 114 5 148 Rate per 100,000 Population 51.9 46.5 14.5 34.4 Source: Report of the Medical Officer of Health on the Public Health and Sanitary Circumstances of Johannesburg during the two years 1st July, 1909, to 30th June, 1911. Note: According to the returns of the Transvaal Chamber of Mines, out of 3,082 deaths from all causes among the native laborers on the Rand, only five deaths, or 0. 2 per cent., were attributed to malignant disease. Practically all of the deaths were medically certified. 704 APPENDIX G Table 225 Mortality from. Cancer in Natal, South Africa European Population, 1902-1912 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1902 74,600 40 53.6 1906 101,314 45 44.4 1903 92,000 30 32.6 1907 99,150 57 57.5 190i 101,183 49 48.4 1908 99,745 53 53.1 1905 101,170 34 33.6 1909 98,934 64 64.7 1910 98,758 58 58.7 1902-1905 368,953 153 41.5 1906-1910 497,901 277 55.6 1911 98,582 63 63.9 1912 98,406 61 62.0 Source: Colony of the Health Officer. Natal, Reports of Table 226 Mortality from Cancer in Natal, South Africa East Indians, 1903-1912 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1903 86,000 10 11.6 1906 98,049 5 5.1 1904 84,500 8 9.5 1907 101,078 14 13.9 1905 91,239 5 5.5 1908 104,120 13 12.5 — 1909 103,906 15 14.4 1903-1905 261,739 23 8.8 1910 1906-1910 122,737 13 60 10.6 529,890 11.3 1911 141,568 11 7.8 1912 145,000 15 10.3 Source: Colony of Natal, the Health Officer. [leports of Table 227 Cases of Cancer in the Colonial Hospital, Sierra Leone, 1870-1909 Years Total Admissions Cases of Cancer Rate per 1,000 Admissions 1870-1879 6,509 4 0.6 1880-1889 5,334 6 1.1 1890-1899 10,610 10 0.9 1900-1909 10,163 26 2.6 Source: Sierra Leone, Annual Reports on the Medical Department. 705 APPENDIX G Table 228 Cases of Cancer in the Colonial Hospital, Sierra Leone, by Organs and Parts 1900-1909 Organ or Part No. of Cases Carcinoma of oesophagus 1 Carcinoma of rectum 3 Carcinoma of uterus 3 Carcinoma of breast 10 Adenosarcoma of breast 1 Adenosarcoma of groin 1 Mellanotic sarcoma of foot 1 Sarcoma of shovdder joint 1 Sarcoma of arm 1 Sarcoma of eye 1 Chondrosarcoma of upper jaw 1 Epithelioma of tongue 1 Papilloma of bladder 1 All organs 26 Source: Sierra Leone, Annual Reports on the Medical Department. Per Cent. 3.8 11.5 11.5 38.5 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 100.0 Table 229 Mortality from Cancer in the City of Freetown, Sierra Leone, 1910-1911 Year 1910 1911 Population 34,128 34,090 Deaths from Cancer 3 6 9 Rate per 100,000 Population 8.8 17.6 1910-1911 68,218 13.2 Soiu'ce: Sierra Leone, Annual Reports on the Medical Department. Table 230 Cases of Tumor Treated in Hospital Da Praia Cape Verde Islands, by Race 1892-1904 White Black Mulatto Total Males Females Males Females Males Females Males Females Cancer Sarcoma Other tumors . . . ... 2 i 7 5 4 4 17 11 3 4 3 11 24 16 5 9 3 15 All tmnors ... 2 1 7 13 23 26 32 40 3 20 49 72 In 1904, seven persons were under treatment for cancer in the hospital of St. Vincente, Cape Verde Islands, two males and five females: Males Females 1 Cancer of pleura 2 Cancer of lips 1 Cancer of intestines 2 Cancer of breast 1 Cancer of uterus 706 APPENDIX G Table 231 Cases of Cancer Treated in Hospital da Praia, Cape Verde Islands, by Organs and Parts, according to Race and Sex, 1892-1904 Organ or Part Males Black Fem lies i 3 1 5 Mulatto Males Fer 1 3 1 i ii 17 nales 1 Eye 1 Extremities 1 1 Lips Tongue 1 9. Rectum Anus ... 1 Breast 3 Ovaries 1 Uterus 9, Vagina Penis 4 All organs 7 11 12 28 Note: In the colony of the Cape Verde Islands and Guinea cancer is believed to be quite common among the colored population. In the colony of St. Thomas and Principe there has been found only one case of cancer among the colored population (cancer uteri, black woman, 40 years of age). In Angola cancer is very rare, only one case is known (cancer mammae, black woman, 28 years of age). In Mosambique cancer has never been found among the colored population. In Portuguese India cancer seems to be quite common, especially in Goa, but the sta- tistical data are very incomplete. Macao (Portuguese China). Cancer is rare. No cases in 1904. One man died from cancer of pharynx in 1900; one woman died, 1895, from cancer uteri spreading to rectum and vesica urinaria; one woman died (year unknown) from cancer uteri spreading to vesica urinaria. 707 APPENDIX G Table 232 Mortality from Cancer in the Countries of Asia Deaths Rate per Population from 100,000 Cancer Population Ceylon 20,076,320 1,133 5.6 Hongkong 1,737,310 140 8.1 India 4,456,200 522 11.7 Japan 242,460,425 145,965 60.2 Penang 1,391,089 143 10.3 Philippine Islands 1,190,154 325 27.3 Shanghai 68,684 38 55.3 Singapore 1,434,780 181 12.6 Total 272,814,962 148,447 54.4 Population, 1911: 57,820,460. Note: The data are given for Ceylon, 1907-1911; for Hongkong, 1907-1911; for India, City of Calcutta, 1908-1912; ior Japan, 1905-1909; for Penang, 1909-1913; for Philippine Islands, City of Manila, 1909-1913; for Shanghai, 1909-1913, Europeans only; for Singapore, 1906-1910. Table 233 Mortality from Cancer in the City of Calcutta, India 1881-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 433,219 54 12.5 1901 847,796 82 9.7 1882 458,053 44 9.6 1902 852,624 91 10.7 1883 482,887 43 8.9 1903 857,451 90 10.5 1884 507,721 31 6.1 1904 862,278 99 11.5 1885 532,555 55 10.3 9.4 1905 1901-1905 867,105 78 440 9.0 1881-1885 2,414,435 4,287,254 10.3 1886 557,389 54 9.7 1906 871,932 94 10.8 1887 582,223 45 7.7 1907 876,759 96 10.9 1888 607,057 63 10.4 1908 881,586 114 12.9 1889 631,891 60 9.5 1909 886,413 80 9.0 1890 656,725 64 286 9.7 9.4 1910 1906-1910 891,240 105 489 11.8 1886-1890 3,035,285 4,407,930 11.1 1891 681,560 65 9.5 1911 896,067 98 10.9 1892 698,184 68 9.7 1912 900,894 125 13.9 1893 714,808 73 10.2 1913 905,721 110 12.1 1894 731,432 71 9.7 1895 748,056 69 9.2 Source: Report of the Health Officer of Calcutta. 1891-1895 3,574,040 346 9.7 Note: Without suburbs. 1896 764,680 57 7.5 1897 781,304 51 6.5 1898 797,927 64 8.0 1899 814,550 79 9.7 -' 1900 831,173 72 323 8.7 8.1 1896-1900 3,989,634 708 APPENDIX G Table 234 Mortality from Cancer in the Hospitals in the Province of Bengal, India 1911-1912 HOSPITALS IN CALCUTTA Cancer in Cancer _^,,. ^ Malignant Tumors Percentage ,Case Total Number of All Mortality- Year of Cases Cases Deaths Causes per 100 1911 25,905 268 34 1.03 12.7 1912 28,246 310 49 1.10 15.8 1911-1912 54,151 578 83 1.07 14.4 HOSPITALS IN BENGAL, EXCLUSIVE OF CALCUTTA 1911 46,012 381 21 0.83 5.5 1912 35,130 215 16 0.61 7.4 1911-1912 81,142 596 37 0.73 6.2 ALL HOSPITALS IN BENGAL 1911 71,917 649 55 0.90 8.5 1912 63,376 525 65 0.83 12.4 1911-1912 135,293 1,174 120 0.87 10.2 Source: Annual Returns of the Hospitals and Dispensaries in Bengal, 1911-1912. Table 235 Mortality from Cancer in Ceylon, 1881-1913 Deaths Rate per Deaths Rate per Year .Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 2,755,558 69 2.5 1901 3,582,697 213 5.9 1882 2,773,389 84 3.0 1902 3,636,736 219 6.0 1883 2,781,711 97 3.5 1903 3,690,775 212 5.7 1884 2,793,689 99 3.5 1904 3,744,814 190 5.1 1885 2,815,166 83 2.9 3.1 1905 1901-1905 3,798,853 207 5.4 1881-1885 13,919,513 432 18,453,875 1,041 5.6 1886 2,830,359 85 3.0 1906 3,852,892 182 4.7 1887 2,855,216 92 3.2 1907 3,906,931 148 3.8 1888 2,901,262 117 4.0 1908 3,960,970 169 4.3 1889 2,938,977 141 4.8 1909 4,015,009 158 3.9 1890 2,980,245 171 5.7 4.2 1910 1906-1910 4,069,048 264 6.5 1886-1890 14,506,059 606 19,804,850 921 4.7 1891 3,021,579 139 4.6 1911 4,124,362 394 9.6 1892 3,088,405 187 6.1 1912 4,179,676 406 9.7 1893 3,121,093 235 7.5 1913 4,234,990 523 12.3 1894 3,144,561 196 6.2 1895 3,193,821 207 6.5 Source: Ceylon, Administration Re- ports. Vita il Statistics. 1891-1895 15,569,459 964 6.2 1896 3,240,501 128 4.0 1897 3,315,768 177 5.3 1898 3,395,519 175 5.2 1899 3,429,745 191 5.6 1900 3,520,574 233 6.6 1896-1900 16,902,107 904 5.3 709 APPENDIX G Table 236 Mortality from Cancer in Ceylon, by Organs and Parts 1911-1913 Deaths Rate per Organ or Part from 100,000 Cancer Population Buccal cavity 422 3.42 Stomach and liver 334 2.71 Peritoneum, intestines and rectum 13 0.11 Female generative organs 50 0.41 Female breast 52 0.42 Skin 29 0.23 Other or not specified organs 423 3.43 All organs 1,323 10.72 Source: Ceylon: Administrative Reports, Vital Statistics. Table 237 Mortality from Cancer in Ceylon, by Organs and Parts, according to Race 1911-1913 Europeans . Burghers. . Sinhalese. . Tamils Moors .... Malays. . . Others. . . . Total. from Cancer Europeans Burghers 5 Sinhalese 32 Tamils 11 Moors 2 Malays Others Population 22,832 79,604 8,033,188 3,328,546 787,398 38,259 51,835 12,341,662 Female Genebative Organs Deaths Rate per 100,000 Population Total. 50 0.40 0.33 0.25 0.41 Buccal Cavity Deaths Rate per from 100,000 Cancer Population 5 6.28 !32 4.13 52 1.56 30 3.81 1 2.61 2 3.86 422 3.42 Breast Deaths from Cancer 1 34 11 5 1 52 Rate per 100,000 Population 4.38 0.42 0.33 0.64 2.61 0.42 Stomach and Liver Deaths from Cancer 3 5 298 16 11 1 334 Rate per 100,000 Population 13.14 6.28 3.71 0.48 1.40 1.93 2.71 Skin Deaths Rate per from 100,000 Cancer Population 20 6 3 29 0.25 0.18 0.38 0.23 Source: Ceylon: Administrative Reports, Vital Statistics. 710 APPENDIX G Table 238 Mortality from Cancer in Ceylon, by Administrative Divisions 1911-1913 District Population Colombo 1,982,286 Negombo 509,029 Kalutara 850,752 Kandy 1,232,085 Matale 321,912 Nuwara Eliya 472,698 Galle 886,442 Matara 688,166 Hambantota 323,133 Jaffna 987,486 Mannar 75,519 Mullaittivu 50,861 Batticaloa 468,686 Trimcomalee 89,243 Kurunegala 911,771 Puttalam 117,924 Chilaw 263,532 Anuradhapura 256,459 Badulla 651,463 Ratnapura 492,131 Kegalla 710,484 All Ceylon 12,342,662 Source: Ceylon: Administrative Reports, Vital Statistics. Deaths Rate per from 100,000 CanctT Population 343 17.3 52 10.2 111 13.0 134 10.9 44 13.7 44 9.3 104 11.7 78 11.3 40 12.4 68 6.9 18 23.8 5 9.8 8 1.7 13 14.6 31 3.4 13 11.0 26 9.9 4 1.6 89 13.7 58 11.8 40 5.6 1,323 10.7 Table 239 Cases of Cancer in the Hospitals of Straits Settlements 1904-1912 Admissions Year All Causes Cancer Per Cent. 1904 23,717 47 0.20 1905 23,990 61 0.25 1906 24,966 1907 26,393 1908 27,913 1909 27,763 1910 32,875 1906-1910 139,910 1911 43,970 1912 38,060 Source: Straits Settlements, Annual Reports on the Medical Department. Deaths All Causes Cancer Per Cent. 3,833 25 0.65 3,685 30 0.81 55 0.22 3,832 27 0.70 84 0.32 3,686 36 0.98 71 0.25 4,031 38 0.94 76 0.27 3,635 35 0.96 93 0.28 0.27 4,500 41 177 0.91 79 19,684 0.90 67 0.15 6,101 26 0.43 85 0.22 4,581 50 1.09 711 APPENDIX G Table 240 Table 241 Mortality from Cancer in Singapore Mortality from Cancer in the Prov- 1904-1913 ince of Penang, Straits Settlements 1909- 1913 Population Deaths from Rate per 100,000 Year Cancer Population Deaths Rate per 1904 253,584 30 11.8 Year Population from Cancer 100,000 Population 1905 261,927 56 21.4 1909 272,043 19 7.0 1906 270,270 48 17.8 1910 275,023 25 9.1 1907 278,613 21 7.5 1911 278,003 29 10.4 1908 286,956 26 9.1 1912 282,176 29 10.3 1909 295,299 57 19.3 1913 284,565 38 13.4 1910 303,642 29 9.6 1909-1913 1,391,810 140 10.1 1906-1910 1,434,780 181 12.6 Source: Straits Settlements, Annual 1911 1912 320,328 328,671 26 39 8.1 11.9 Reports on Deaths the Registration of Births and 1913 337,014 11 3.3 Note : Includes the Provinces of Welles- Source: Straits Settlements Annual ley and Dindings. Reports on the Registration of Births and Deaths. Table 242 Cases of Cancer in Tan Tock Seng's Hospital, Singapore, by Organs and Parts 1907-1912 Carcinoma of Glands of neck . . . Lungs (Esophagus Stomach Liver Intestines Pancreas Kidney Suprarenal glands All carcinoma Sarcoma of Mediastinum . Heart No. of Cases Kidney. Bones . . All sarcoma . . . Epithelioma of Jaw Tongue Pharynx Scalp Penis Arising from scars . All epithelioma . Glioma of brain . 7 3 21 31 1 1 1 2 95 5 1 1 3 10 2 1 4 4 14 All organs 121 Source: Straits Settlements, Annual Reports on the Medical Department. Per Cent. 23.1 5.8 2.5 17.4 25.6 0.8 0.8 0.8 1.7 78.5 4.1 0.8 0.8 2.5 0.8 1.7 1.7 0.8 3.3 3.3 11.6 1.7 100.0 712 APPENDIX G Table 243 Admissions and Mortality from Cancer, Victoria Hospital, Seychelles 1900-1902 and 1907-1911 Admissions Deaths Per Cent. Per Cent Year All Causes Cancer of AH Causes All Causes Cancer of All Causes 1900 219 2 0.9 10 2 20.0 1901 249 2 0.8 17 1902 26G 6 2.3 14 1 7.1 1900-1902 734 10 1.4 2 0.8 41 14 3 7 3 1907 266 1908 369 2 0.5 14 1909 369 4 1.1 26 1 3.8 1910 460 13 2.8 30 2 6.7 1911 579 7 1.2 28 1.4 26 110 2 5 7.7 1907-1911 2,043 4.5 Source: Selections from Colonial Medical Reports for 1900-1902. Colony of Seychelles, Blue Book. Table 244 Admissions and Mortality from Cancer, by Organs and Parts Victoria Hospital, Seychelles, 1907-1911 Organ or Part Stomach Pylorus Rectum Bladder Uterus Ovary Other or not specified Adenocarcinoma Epithelioma Sarcoma Admissions Number Per Cent 4 14.3 1 3.6 1 3.6 1 3.6 9 32.1 2 7.1 2 7.1 1 3.6 5 17.9 2 7.1 All organs 28 Source: Colony of Seychelles, Blue Book. 100.0 Deaths Number Per Cent. 1 20.0 1 20.0 40.0 20.6 100.0 Table 245 Mortality from Cancer among Europeans in Dutch East Indies 1911-1912 Year 1911 1912 Population 63,000 63,000 Deaths from Cancer 54 51 Rate per 100,000 Population 85.7 81.0 1911-1912 126,000 105 83.3 Source: Handelingen der Staaten-Gen- eraal. Bijlagen 1912-1913, 1913-1914. Ned- erlandsch-Indie . 713 APPENDIX G Table 246 Mortality from Cancer in Hongkong, China, by Race 1901-1912 Civil Eukopeans Chinese Deaths Rate per Deaths Rate per Year Population from 100,000 Population from 100,000 Cancer Population Cancer Population 1901 9,560 6 62.8 280,564 21 7.5 1902 10,082 7 69.4 285,677 11 3.9 1903 10,605 2 18.9 290,790 13 4.5 1904 11.128 3 27.0 295,903 14 4.7 1905 11,651 8 26 7 68.7 49.0 57.5 301,016 20 79 15 6.6 1901-1905 53,026 1,453,950 306,130 5.4 1906 12,174 4.9 1907 12,162 7 57.6 315,862 19 6.0 1908 12,149 7 57.6 325,594 10 3.1 1909 12,136 6 49.4 335,326 24 7.2 1910 12,123 5 32 5 41.2 52.7 41.3 345,058 21 89 36 6.1 1906-1910 60,744 1,627,970 354,790 5.5 1911 12,110 10.1 1912 12,400 6 48.4 356,020 37 10.4 Source: Reports on the Health and Sanitary Condition of the Colony of Hongkong. Table 247 Mortality from Cancer, by Organs and Parts, among the Chinese Population of Hongkong 1895-1904 Deaths Rate per from 100,000 Carcinoma of Cancer Population Mouth and jaw 7 0.26 CEsophagus 3 0.11 Stomach 19 0.72 Rectum 4 0.15 Peritoneum 3 0.11 Liver 14 0.53 Skin 3 0.11 Neck 1 0.04 Breast 6 0.23 Uterus 14 0.53 Vagina 1 0.04 Bladder 1 0.04 Penis 3 0.11 Other or not specified 24 0.90 Sarcoma 16 0.60 All organs 119 4.48 Source: Correspondence relating to the Cancer Research Scheme, London, 1906. 714 APPENDIX a Table 248 Table 249 Mortality from Cancer in Shanghai Mortality from Cancer in Japan China, among Resident Foreign 1899-1911 Pomi1ci<-n 1898-1Q14 D th T> Resident Deaths Rate per Year Population from 100,000 Year Foreign from 100,000 Cancer Population Population Cancer Population 1899 44,003,530 19,382 44.0 1898 5,938 1 16.8 1900 44,577,790 20,334 45.6 1899 6,356 4 62.9 1900 6,774 5 73.8 1901 45,152,050 22,149 49.1 1902 45,726,310 24,598 53.8 1901 7,718 4 51.8 1903 46,300,570 25,550 55.2 1902 8,662 2 23.1 1904 46,846,690 25,993 55.5 1903 9,607 3 31.2 1905 47,392,810 26,668 56.3 1904 10,552 3 28.4 1905 11,497 5 43.5 35.4 1901-1905 1906 231,418,430 47,938,930 124,958 27,863 54.0 1901-1905 48,036 17 58.1 1907 48,492,085 28,451 58.7 1906 11,904 6 50.4 1908 49,045,240 30,440 62.1 1907 12,312 6 48.7 1909 49,591,360 32,543 65.6 1908 12,720 8 62.9 1910 50,137,480 32,741 65.3 1909 13,128 8 60.9 1910 13,536 5 36.9 51.9 1906-1910 245,205,095 1911 50,683,600 152,038 33,888 62.0 1906-1910 63,600 33 66.9 1911 13,770 8 58.1 Source: Mouvement de la Population 1912 14,000 8 57.1 de L'Emp re du Japon. 1913 14,250 9 63.2 1914 14,300 .14 97.9 Source: Shanghai Municipal Council, Health Department, Annual Reports. Table 248a Surgical Cases of Malignant Tumor in the Yunghun Hospital Fukien, China, by Organs and Parts 1911-1914* Organ or Part Carcinoma of breast Carcinoma of glands in neck, recurrent from breast. Carcinoma of ovaries Sarcoma of abdominal wall Sarcoma of neck glands Sarcoma of testicle Sarcoma of finger Myeloid sarcoma of tibia Epithelioma of cheek Cases 4 Per Cent. 30.8 7.7 7.7 15.4 7.7 7.7 7.7 7.7 7.7 100.0 All organs 13 General surgical and gynecological operations performed, exclu- sive of operations on eyes and teeth 1,079 Operations for malignant tumors in per cent, of total 1.2 Source: Annual Reports of the Yunghun Hospital, Fukien (English Presbyterian Mission). *Three fiscal years. 715 APPENDIX G Table 250 Mortality from Cancer in Japan, by Sex 1899-1910 MALES FEMALES Year 1899 1900 Population 22,199,781 22,493,953 Deaths from Cancer 9,780 10,250 Rate per 100,000 Population 44.1 45.6 Year 1899 1900 Population 21,803,749 22,083,837 Deaths from Cancer 9,602 10,084 Rate per 100,000 Population 44.0 45.7 1901 1902 1903 1904 1905 22,788,240 23,082,641 23,381,788 23,666,948 23.923,890 11,050 12,304 12,972 13,177 13,564 48.5 53.3 55.5 55.7 56.7 54.0 1901 1902 1903 1904 1905 1901-1905 22,363,810 22,643,669 22,918,782 23.179,742 23,468,920 11,099 12,294 12,578 12,816 13,104 49.6 54.3 54.9 55.3 55.8 1901-1905 116,843,507 63,067 114,574,923 61,891 54.0 1906 1907 1908 1909 1910 24,180,396 24,440,011 24,708,992 24,974,209 25.249,235 14,261 14,411 15,352 16,602 16,604 59.0 59.0 62.1 66.5 65.8 62.5 1906 1907 1908 1909 1910 1906-1910 23,758,534 24,052,074 24,336,248 24,617,151 24,888,245 13,602 14,040 15,088 15,941 16,137 57.3 58.4 62.0 64.8 64.8 1906-1910 123,552,843 77,230 121,652,252 74,808 61.5 Source: Mouvement de L'Empire du Japon. de la Population Table 251 Mortality from Cancer in Japan, by Organs and Parts, according to Sex 1909-1910 MALES Deaths from Carcinoma of Cancer Buccal cavity 1,098 Stomach and liver 24,331 Peritoneum, intestines rectum. . . 1,777 Female generative organs Breast Skin 444 Other organs 4,328 Not specified 329 Other malignant tumors 899 Rate per 100,000 Population 2.2 48.4 3.5 0.9 8.6 0.7 1.8 FEMALES Deaths Rate per from 100,000 Cancer Population 429 0.9 15,530 31.4 1,684 3.4 10,322 20.8 878 1.8 290 0.6 1,888 3.8 307 0.6 750 1.5 All organs 33,206 66.1 32,078 Source : Statistlque des causes de deces de L'Empire du Japon. 64.8 716 APPENDIX G Table 252 Mortality from Cancer in Japan, by Age and Sex 1908-1910 MALES Deaths Ages Population from Cancer Under 25 38,732,576 378 25-34 11,607,034 670 35-44 8,729,629 3,202 45-54 6,856,318 10,333 55-64 5,417,615 18,737 65-74 2,577,676 12,107 75 and over 1,011,588 . 3,131 All ages 74,932,436 48,558 FEMALES Under 25 37,873,379 450 25-34 11,423,302 2,154 35-44 8,336,722 6,288 45-54 6,564,522 10,797 55-64 5,419,977 14,698 65-74 2,894,592 9,436 75 and over 1,329,150 3,343 All ages 73,841,644 47,166 Source: Statistique des causes de deces de L'Empire du Japon. Rate per 100,000 Population 1.0 5.8 36.7 150.7 345.9 469.7 309.5 64.8 1.2 18.9 75.4 164.5 271.2 326.0 251.5 63.9 Table 253 Mortality from Cancer in Tokyo 1904-1910 Year Population Deaths from Cancer Rate per 100,000 Population 1904 1905 1,400,000 1,459,000 1,074 1,071 76.7 73.4 1906 1907 1908 1909 1910 1,523,000 1,580,000 1,601,000 1,623,079 1,805,800 1,107 1,111 1,191 1,225 1,284 72.7 70.3 74.4 75.5 71.1 1906-1910 8,132,879 5,918 72.8 Source: Tenth Annual Statistics of the City of Tokyo, 1913. 717 APPENDIX G Table 254 Mortality from Cancer in Tokyo, by Sex 1904-1910 MALES FEMALES Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1904 1905 778,000 811,000 555 549 71.3 67.7 1904 1905 622,000 648,000 519 522 83.4 80.6 1906 1907 1908 1909 1910 846,000 878,000 890,000 902,433 1,004,025 576 602 604 627 646 68.1 68.6 67.9 69.5 64.3 67.6 1906 1907 1908 1909 1910 1906-1910 677,000 702,000 711,000 720,646 801,775 531 509 • 587 598 638 78.4 72.5 82.6 83.0 79.6 1906-1910 4,520,458 3,055 3,612,421 2,863 79.3 Source: Tenth Annual Statistics of the City of Tokyo, 1913. Table 255 Mortality from Cancer in Osaka, by Sex 1906-1910 TOTAL MALES Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1906 1907 1908 1909 1910 1,134,332 1,180,461 1,226,590 1,232,982 1,250,000 625 587 655 698 739 55.1 49.7 53.4 56.6 59.1 54.8 1906 1907 1908 1909 1910 1906-1910 621,047 646,302 671,558 675,058 685,000 309 292 312 361 379 49.8 45.2 46.5 53.5 55.3 1906-1910 6,024,365 3,304 3,298,965 1.653 50.1 Year 1906 1907 1908 1909 1910 FEMALES Deaths Population 513,285 534,159 555,032 557,924 565,000 from Cancer 316 295 343 337 360 Rate per 100,000 Population 61.6 55.2 61.8 60.4 63.7 1906-1910 2,725,400 1,651 60.6 Source: Mouvement de la Population de L'Empire du Japon, 1906-1910. 718 APPENDIX G Table 256 Table 257 Mortality from Cancer in Kyoto Mortality from Cancer in Manila by Sex Philippine Islands 1906-191 Year 1903-1^ H3 Deaths TOTAL Rate per Deaths Rate per (Ending Population from 100,000 Year Population from 100,000 June 30) Cancer, Population Cancer Population 1903 219,941 29 13.2 1906 417,704 381 91.2 1904 220,841 28 12.7 1907 430,083 412 95.8 1905 221,741 35 15.8 1908 442,462 381 86.1 1909 456,247 436 95.6 1906 222,641 38 17.1 1910 470,000 376 80.8 1907 223,542 62 23.3 1908 227,164 63 27.7 1906-1910 2,216,496 1,986 89.6 ■ 1909 230,786 64 27.7 MALES 1910 234,409 72 30.7 1906 215,285 218 101.3 1907 221,665 224 101.1 1906-1910 1,138,542 289 25.4 1908 228,045 203 89.0 1909 235,150 226 96.1 1911 238,031 68 28.6 1910 242,050 201 83.0 1912 241,653 63 26.1 1913 245,275 58 23.6 1906-1910 1,142,195 1,072 93.9 Source: Annual Reports of the Bureau of FEMALEb Health for the Philippin e Islands 1906 202,419 163 80.5 1907 208,418 188 90.2 1908 214,417 178 83.0 1909 221,097 210 95.0 1910 227,950 175 76.8 85.1 1906-1910 1,074,301 914 Source: Mouvement de la Population de L'Empire du Japon, 1906-1910 Table 258 Mortality from Cancer in Manila, by Organs and Parts according to Race 1908-1913 White Race Organ or Part Buccal cavity Stomach and liver Peritoneum, intestines, rectum Female generative organs Breast Skin Other or not specified AU organs Deaths from Cancer Rate per 100,000 Population 5.1 10.1 20 12.6 50.6 Filipinos Deaths from Cancer 43 59 25 9 82 293 Rate per 100,000 Population 4.0 5.4 2.0 4.9 2.3 0.8 7.6 27.0 Chinese Deaths Rate per from 100,000 Cancer Population 3 4.7 5 7.8 12 6.3 18.8 Source: Annual Reports of the Bureau of Health for the Philippine Islands. 719 APPENDIX G Table 259 Mortality from Cancer in the Countries of Australasia Deaths Rate per Population from 100,000 Cancer Population Hawaii 962,860 392 40.7 New South Wales 8,142,200 5,948 73.1 New Zealand 4,963,912 3,731 75.2 Northern Territory 6,678 3 44.9 Queensland 2,961,089 1,870 63.2 South Austraha 1,996,995 1,525 76.4 Tasmania 950,717 621 65.3 Victoria 6,521,936 5,441 83.4 Western Austraha 1,380,353 814 59.0 Total , 27,886,740 20,345 73.0 Population, 1911: 5,703,425. Note: The data are given for Hawaii, 1908-1912, for New South Wales, 1908-1912, for New Zealand, 1908-1912, for Northern Territory, 1911-1912, for Queensland, 1908- 1912, for South Australia, 1908-1912, for Tasmania, 1908-1912, for Victoria, 1908-1912, for Western Australia, 1908-1912. Table 260 Mortality from Cancer in the Commonwealth of Australia 1881-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 2,269,135 784 34.6 1901 3,790,710 2,401 63.3 1882 2,347,410 800 34.1 1902 3,847,998 2,467 64.1 1883 2,446,910 896 36.6 1903 3,893,329 2,396 61.5 1884 2,555,731 956 37.4 1904 3,942,730 2,371 60.1 • 1885 2,650,123 942 35.5 35.7 1905 1901-1905 4,001,117 2,539 63.5 1881-1885 12,269,309 4,378 19,475,884 12,174 62.5 1886 2,741,286 1,097 40.0 1906 4,060,324 2,608 64.2 1887 2,834,708 1,156 40.8 1907 4,123,729 2,940 71.3 1888 2,931,521 1,215 41.4 1908 4,194,410 2,921 69.6 1889 3,022,077 1,375 45.5 1909 4,274,617 3,112 72.8 1890 3,106,917 1,358 43.7 42.4 1910 1906-1910 4,370,185 3,205 73.3 1886-1890 14,636,509 6,201 21,023,265 14,786 70.3 1891 3,196,172 1,593 49.8 1911 4,490,366 3,321 74.0 1892 3,273,371 1,557 47.6 1912 4,644,852 3,537 76.1 1893 3,333,825 1,613 48.4 1913 4,803,661 3,603 75.0 1894 3,394,328 1,681 49.5 1895 3,459,192 1,771 51.2 Source: Annual Reports of the Regis- trar-General of Rirths DpatVis anr\ Mnr- 1891-1895 16,656,888 8,215 49.3 riages in England and Wales Official Statistics, Commonwealth of 1896 3,522,362 1,904 54.1 Australia. Annual Bulletins of Common- 1897 3,585,442 1,971 55.0 wealth Demography. 1898 3,641,251 2,145 58.9 1899 3,690,353 2,200 59.6 1900 3,740,665 2,341 62.6 58.1 1896-1900 18,180,073 10,561 720 APPENDIX G Table 261 Mortality from Cancer in the Commonwealth of Australia by Organs and Parts, according to Sex 1908-1912 MALES Organ or Part Deaths from Cancer Lips 153 Tongue 452 Mouth 117 Jaw 380 Pharynx 248 Esophagus 242 Stomach 2,254 Liver and gall-bladder 1,045 Peritoneum and mesentery 36 Intestines 605 Rectum 292 Pancreas 172 Ovary and fallopian tube Uterus Breast 11 Skin 335 Larynx 121 Lungs and pleura 99 Kidneys and suprarenal glands ... 98 Bladder 172 Prostate 170 Brain 17 Other organs 889 Not specified 517 All organs 8,425 Rate per 100,000 Population 1.3 4.0 1.0 3.3 2.2 2.1 19.7 9.2 0.3 5.3 2.5 1.5 0.1 2.9 1.1 0.9 0.9 1.5 1.5 0.1 7.9 4.5 73.8 FEMALES Deaths Rate per from 100,000 Cancer Population 11 0.1 21 0.2 10 0.1 61 0.6 25 0.2 51 0.5 1,246 11.8 1,024 9.7 45 0.4 640 6.1 268 2.5 101 0.9 118 1.0 1,456 13.8 1,117 10.6 157 1.5 15 0.1 58 0.5 54 0.5 60 0.6 20 0.2 600 5.7 513 4.8 rt R'71 na et 7,671 Males, 45 years and over, 20.11 per cent, of population. Females, 45 years and over, 17.95 per cent, of population. Source: Ofl5cial Statistics, Commonwealth of Australia. Annual Bulletins of Com- monwealth Demography. 721 APPENDIX G Table 262 Mortality from Cancer in the Commonwealth of Australia, by Age and Sex 1908-1912 MALES Population Under 25 5,791,262 25-34 1,840,288 35-44 1,471,775 45-54 1,195,675 55-64 612,669 65-74 343,414 75 and over 154,023 Not stated All ages 11,409,106 FEMALES Under 25 5,622,866 25-34 1,726,374 35-44 1,310,100 45-54 958,275 55-64 500,796 65-74 309,564 75 and over 137,349 Not stated All ages 10,565,324 Source: Official Statistics, Commonwealth of Australia, mon wealth Demography. Deaths Rate per from 100,000 Cancer Population 191 3.3 157 8.5 571 38.8 1,643 137.4 2,095 341.9 2,401 699.2 1,356 880.4 11 8,425 73.8 149 2.6 249 14.4 948 72.4 1,688 176.1 1,746 348.6 1,763 569.5 1,126 819.8 2 7,671 72.6 Annual Bulletins of Com- APPENDIX G Table 263 Mortality from Cancer in New South Wales 1881-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 765,015 216 28.2 1906 1,484,600 1,027 69.2 1882 798,540 215 26.9 1907 1,517,900 1,085 71.5 1883 838,155 215 25.7 1908 1,545,700 1,058 68.4 1884 883,145 233 26.4 1909 1,577,200 1,166 73.9 1885 927,275 267 28.8 27.2 1910 1906-1910 1,616,200 1,179 72.9 1881-1885 4,212,130 1,146 7,741,600 5,515 71.2 1886 969,455 333 34.3 1911 1,664,500 1,233 74.1 1887 1,004,835 354 35.2 1912 1,738,600 1,312 75.5 1888 1,035,705 404 39.0 1913 1,809,400 1,332 73.6 1889 1,066,450 393 36.9 1890 1,101,840 392 35.6 Source: Vital Statistics of Pn 'ew South Wales, 1881-1 01 f? 1886-1890 5,178,285 1,876 36.2 1891 1,142,025 516 45.2 1892 1,176,990 510 43.3 1893 1,203,170 489 40.6 1894 1,226,900 516 42.1 1895 1,250,760 556 44.5 43.1 1891-1895 5,999,845 2,587 1896 1,270,620 627 49.3 1897 1,290,375 693 53.7 1898 1,312,455 714 54.4 1899 1,333,605 761 57.1 1900 1,354,335 765 56.5 54.3 1896-1900 6,561,390 3,560 1901 1,366,900 847 62.0 1902 1,388,400 869 62.6 1903 1,407,400 930 66.1 1904 1,428,700 954 66.8 1905 1,454,800 965 . 66.3 64.8 1901-1905 7,046,200 4,565 723 APPENDIX G Table 264 Table 265 Mortality from Cancer in New South Mortality from Cancer in New South Wales, Males, 1881-19 13 Rate per Wal es, Females 1881-] Deaths 1913 Deaths Rate per Year Population from lOO.Ouo Year Population from 100,000 Cancer Population Cancer Population 1881 419,025 120 28.6 1881 345,990 96 27.7 1882 438,060 118 26.9 1882 360,480 97 26.9 1883 460,540 124 26.9 1883 377,615 91 24.1 1884 486,145 123 25.3 1884 397,000 110 27.7 1885 510,670 148 29.0 27.4 1885 1881-1885 416,605 119 28.6 1881-1885 2,314,440 633 1,897,690 513 27.0 1886 533,145 171 32.1 1886 436,310 162 37.1 1887 550,805 209 37.9 1887 454,030 145 31.9 1888 565,770 208 36.8 1888 469,935 196 41.7 1889 581,100 217 37.3 1889 485,350 176 36.3 1890 599,330 229 38.2 36.5 1890 1886-1890 502,510 163 32.4 1886-1890 2,830,150 1,034 2,348,135 842 35.9 1891 618,847 297 48.0 1891 523,178 219 41.9 1892 634,790 269 42.4 1892 542,200 241 44.4 1893 646,650 250 38.7 1893 556,520 239 42.9 1894 657,420 308 46.8 1894 569,480 208 36.5 1895 667,800 311 46.6 44.5 1895 1891-1895 582,960 245 42.0 1891-1895 3,225,507 1,435 2,774,338 1,152 41,5 1896 676,350 333 49.2 1896 594,270 294 49.5 1897 686,137 369 53.8 1897 604,238 324 53.6 1898 696,952 398 57.1 1898 615,503 316 51.3 1899 706,167 410 58.1 1899 627,438 351 55.9 1900 714,757 409 57.2 55.1 1900 1896-1900 639,578 356 55.7 1896-1900 3,480,363 1,919 3,081,027 1,641 53.3 1901 716,300 484 67.6 1901 650,600 363 55.8 1902 725,700 500 68.9 1902 662,700 369 55.7 1903 733,800 492 67.0 1903 673,600 438 65.0 1904 744,300 457 61.4 1904 684,400 497 72.6 1905 757,900 525 69.3 66.8 1905 1901-1905 696,900 440 63.1 1901-1905 3,678,000 2.458 3,368,200 2.107 62.6 1906 772,800 520 67.3 1906 711,800 507 71.2 1907 789,400 632 80.1 1907 728,500 453 62.2 1908 801,900 537 67.0 1908 743,800 521 70.0 1909 818,200 608 74.3 1909 759,000 558 73.5 1910 840,100 623 74.2 72.6 1910 1906-1910 776,100 556 71.6 1906-1910 4,022,400 2,920 3,719,200 2,595 69.8 1911 868,300 666 76.7 1911 796,200 567 71.2 1912 913,100 726 79.5 1912 825,500 586 71.0 1913 951,200 739 77.7 1913 858,200 593 69.1 Source: Vital Statistics for 1913 and Source: Vital Statistics for 1913 and previous years, New South Wales. previous years. New South -Wales. 724 901-1910 1911 11.2 13.0 53.9 54.6 154.1 167.5 356.5 345.9 677.1 672.7 834.9 945.2 APPENDIX G Table 266 Mortality from Cancer in New South Wales, by Age and Sex 1881-1911 TOTAL Rate per 100,000 Popdlation Ages 1881-1890 1891-1900 25-34 10.1 10.7 35-44 38.2 49.6 45-54 113.7 145.2 55-64 210.9 315.2 65-74 336.3 471.8 75 and over 392.4 634.3 All ages 32.2 48.8 67.7 74.2 MALES 25-34 7.5 9.4 35-44 28.8 36.3 45-54 93.6 121.3 55-64 119.5 303.6 65-74 347.8 513.2 75 and over 412.4 637.8 All ages 32.4 49.9 69.0 76.8 FEMALES 25-34 13.6 12.4 35-44 52.5 67.9 45-54 146.3 179.3 55-64 228.8 332.0 65-74 318.5 430.0 75 and over 359.7 629.5 All ages 31.9 47.7 66.2 71.3 Source: The Official Year Book of New South Wales, 1913. 8.9 11.9 39.3 45.5 125.3 141.9 349.6 355.6 720.0 741.4 863.6 888.9 13.7 14.2 71.6 65.0 192.1 20U.3 365.4 333.5 620.6 589.8 799.8 1,015.1 725 APPENDIX G Table 267 Mortality from Cancer in Sydney New South Wales 1891-1913 Year 1891 1892 1893 1894 1895 Population 389,655 406,540 418,865 429,410 440,020 1896 1897 1898 1899 1900 448,850 457,630 467,445 476,850 486,070 1896-1900 2,336,845 1901 1902 1903 1904 1905 493,810 506,765 518,960 524,695 530,655 1906 1907 1908 1909 1910 545,065 567,005 584,640 599,000 613,500 1911 1912 1913 639,515 675,800 710,100 Deaths from Cancer 210 189 199 185 1891-1895 2,084,490 1,027 1901-1905 2,574,885 1,944 481 493 493 571 548 1906-1910 2,909,210 2,586 572 621 677 Rate per 100,000 Population 53.9 60.0 45.1 46.3 42.0 49.3 269 59.9 303 66.2 326 69.7 353 74.0 326 67.1 1,577 67.5 358 72.5 392 77.4 377 72.6 382 72.8 435 82.0 75.5 86.9 84.3 95.3 89.3 88.9 89.4 91.9 95.3 Source: New South Wales, Vital Sta- tistics, Annual Reports, 1891-1913. Government Statistician's Reports on the Vital Statistics of Sydney and Suburbs, 1911-1912. Table 268 Mortality from Cancer in Sydney Males, 1891-1913 Year Population 1891 196,932 1892 205,059 1893 210,857 1894 215,736 1895 220,626 1891-1895 1,049,210 1896 1897 1898 1899 1900 224,605 228,540 232,975 237,185 241,285 1896-1900 1,164,590 1901 1902 1903 1904 1905 244,633 250,798 256,574 259,147 261,825 1901-1905 1,272,977 1906 1907 1908 1909 1910 268,663 279,193 287,584 294,349 301,167 Deaths from Cancer 113 110 86 100 497 125 157 149 177 148 756 172 193 170 155 902 215 280 231 280 271 1906-1910 1,430,956 1,277 1911 310,593 265 1912 328,216 301 1913 344,874 328 Rate per 100,000 Population 57.4 53.6 40.8 46.4 39.9 47.4 55.7 68.7 64.0 74.6 61.3 64.9 70.3 77.0 66.3 59.8 81.0 70.9 80.0 100.3 80.3 95.1 90.0 89.2 85.3 91.7 95.1 Source: New South Wales, Vital Sta- tistics, Annual Reports, 1891-1913. Government Statistician's Reports on the Vital Statistics of Sydney and Suburbs, 1911-1912. 726 APPENDIX G Table 269 Mortality from Cancer in Sydney Females, 1891-1913 Year 1891 1892 1893 1894 1895 Population 192,723 201,481 208,008 213,674 219,394 1891-1895 1,035,^ 1896 1897 1898 1899 1900 224,245 229,090 234,470 239,665 244,785 1896-1900 1,172,255 1901 1902 1903 1904 1905 249,177 255,967 262,386 265,548 268,830 Deaths from Cancer 97 134 103 99 97 530 144 146 177 176 178 821 186 199 207 227 223 Rate per 100,000 Population 50.3 66.5 49.5 46.3 44.2 1901-1905 1,301,908 1,042 1906 1907 1908 1909 1910 276,402 287,812 297,056 304,651 312,333 213 262 291 277 1906-1910 1,478,254 1,309 1911 1912 1913 328,922 347,584 365,226 307 320 349 64.2 63.7 75.5 73.4 72.7 70.0 74.6 77.7 78.9 85.5 83.0 80.0 96.2 74.0 88.2 95.5 88.7 88.6 93.3 92.1 95.6 Source: New South Wales, Vital Sta- tistics, Annual Reports, 1891-1913. Government Statistician's Reports on the Vital Statistics of Sydney and Suburbs, 1911-1912. Table 270 Mortality from Cancer in Victoria 1881-1913 Year 1881 1882 1883 1884 1885 Population 866,285 883,365- 902,609 924,115 947,808 1886 1887 1888 1889 1890 976,778 1,009,597 1,052,277 1,092,008 1,119,333 1891 1892 1893 1894 1895 1,146,050 1,163,560 1,172,459 1,179,163 1,183,916 1896 1897 1898 1899 1900 1,182,763 1,180,978 1,182,194 1,185,411 1,192,377 1901 1902 1903 1904 1905 1,204,909 1,214,226 1,215,521 1,216,905 1,223,796 1906 1907 1908 1909 1910 1,236,729 1,252,471, 1,265,782 1,281,058 1,299,565 1911 1912 1913 1,321,212 1,354,319 1,393,180 Deaths from Cancer 351 373 450 446 445 51.2 i 1881-1885 4,524,182 2,065 496 527 521 629 626 1886-1890 5,249,993 2,799 699 684 734 744 760 1891-1895 5,845,148 3,621 789 774 864 842 817 1896-1900 5,923,723 4,086 852 920 893 953 1901-1905 6,075,357 4,500 926 992 1,005 1,030 1,081 1906-1910 6,335,605 5,034 1,100 1,225 1,164 Rate per 100,000 Population 40.5 42.2 49.9 48.3 47.0 45.6 50.8 52.2 49.5 57.6 55.9 53.3 61.0 58.8 62.6 63.1 64.2 61.9 66.7 65.5 73.1 71.0 68.5 69.0 73.2 70.2 75.7 73.4 77.9 74.1 74.9 79.2 79.4 80.4 83.2 79.5 83.3 90.3 83.5 Vic- Source: Statistical Register of toria for 1912. OflBcial Statistics, Commonwealth of Aus tralia. Commonwealth Demography, 1913. 727 APPENDIX G Table 271 Table 272 Mortality from Cancer in Victoria Mortality from Cancer in Victoria Males, 1881 -1913 Deaths Rate per F emales, 1881-1913 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Populatioi 1881 454,170 172 37.9 1881 412,115 179 43.4 1882 462,285 208 45.0 1882 421,080 165 39.2 1883 472,230 234 49.6 1883 430,379 216 50.2 1884 483,968 221 45.7 1884 440,147 225 51.1 1885 497,182 234 47.1 45.1 1885 1881-1885 450,626 211 46.8 1881-1885 2,369,835 1,069 2,154,347 996 46.2 1886 513,981 247 48.1 1886 462,797 249 53.8 1887 532,540 275 51.6 1887 477,057 252 52.8 1888 556,321 276 49.6 1888 495,956 245 49.4 1889 577,049 324 56.1 1889 514,959 305 59.2 1890 589,096 338 57.4 52.7 1890 1886-1890 530,237 288 54.3 1886-1890 2,768,987 1,460 2,481,006 1,339 54.0 1891 600,957 407 67.7 1891 545,093 292 53.6 1892 607,531 359 59.1 1892 556,029 325 58.5 1893 609,083 406 66.7 1893 563,376 328 58.2 1894 609,440 375 61.5 1894 569,723 369 64.8 1895 608,656 418 68.7 1895 575,260 342 59.5 1891-1895 3,035,667 1,965 64.7 1891-1895 2,809,481 1,656 58.9 1896 603,715 422 69.9 1896 579,048 367 63.4 1897 599,559 396 66.0 1897 581,419 378 65.0 1898 598,977 445 74.3 1898 583,217 419 71.8 1899 599,048 444 74.1 1899 586,363 398 67.9 1900 600,769 435 72.4 71.4 1900 1896-1900 591,608 382 64.6 1896-1900 3,002,068 2,142 2,921,655 1,944 66.5 1901 606,129 483 79.7 1901 598,780 399 66.6 1902 608,437 444 73.0 1902 605,789 408 67.4 1903 607,250 487 80.2 1903 608,271 433 71.2 1904 606,432 453 74.7 1904 610,473 440 72.1 1905 609,903 498 81.7 77.8 1905 1901-1905 613,893 455 74.1 1901-1905 3,038,151 2,365 3,037,206 2,135 70.3 1906 616,262 466 75.6 1906 620,467 460 74.1 1907 623,643 499 80.0 1907 628,828 493 78.4 1908 630,461 497 78.8 1908 635,321 508 80.0 1909 638,671 530 83.0 1909 642,387 500 77.8 1910 648,028 564 87.0 81.0 1910 1906-1910 651,537 517 79.4 1906-1910 3,157,065 2,556 3,178,540 2,478 78.0 1911 660,038 535 81.1 1911 661,174 565 85.5 1912 675,534 572 84.7 1912 678,785 653 96.2 1913 695,638 574 82.5 1913 697,542 590 84.6 Source: Statistical Register of Vic- toria for 1912. Official Statistics, Commonwealth of Aus- tralia, Commonwealth Demography, 1913. Source: Statistical Register of Vic- toria for 1912. Official Statistics, Commonwealth of Aus- tralia, Commonwealth Demography, 1913. 728 APPENDIX G Table 273 Mortality from Cancer in Victoria, by Age and Sex 1880-1882, 1890-1892, 1900-1902, 1909-1911 Rate per 100,000 of Population MALES Ages 1880-1882 1890-1892 Under 5 2.9 1.8 5-9 2.4 1.0 lO-U 1.8 1.1 15-19 0.7 1.7 20-24 2.5 3.2 25-34 8.0 8.1 35-44 41.2 42.9 45-54 101.6 148.3 55-64 220.1 319.2 65-74 345.5 527.5 75 and over 451.2 585.5 All ages 42.9 61.6 FEMALES Under 5 1.2 0.9 5-9 1.2 1.0 10-14 0.6 0.6 15-19 2.6 1.2 20-24 3.9 2.2 25-34 26.5 16.8 35-44 73.2 74.3 45-54 150.7 180.0 55-64 293.5 317.9 65-74 326.8 539.6 75 and over 275.6 495.5 All ages 42.7 55.7 Source: Victorian Year-book, 1911-1912. 900-1902 1909-1911 3.0 6.4 4.2 2.0 2.0 1.6 2.2 2.4 3.3 4.3 12.6 8.6 36.9 35.8 141.4 158.5 360.0 355.6 590.4 733.6 740.4 852.5 75.2- 66.4 83.6 2.6 1.4 0.4 0.5 2.1 2.8 4.4 2.3 3.5 16.1 13.7 60.5 72.9 181.3 162.3 330.5 330.1 500.8 574.1 627.0 774.9 80.7 729 APPENDIX G Table 274 Table 275 Mortality from Cancer in South Mortality from Cancer in South Australia, 1881-1913 Rate per Aust ralia, Males , 1882- Deaths 1913 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 277,695 91 32.8 1882 150,325 52 34.6 1882 285,400 89 31.2 1883 153,767 47 30.6 1883 293,223 86 29.3 1884 157,812 58 36.8 1884 301,505 109 36.2 1885 159,106 52 32.7 1885 305,063 100 32.8 1882-1885 621,010 209 33.7 1881-1885 1,462,886 475 32.5 1886 157,758 46 29.2 1886 303,800 104 34.2 1887 157,606 59 37.4 1887 304,017 110 36.2 1888 157,303 49 31.2 1888 305,244 116 38.0 1889 158,025 67 42.4 1889 1890 307,374 311,976 133 129 43.3 41.3 1890 160,695 68 42.3 1886-1890 791,387 289 36.5 1886-1890 1,532,411 592 38.6 1891 162,950 86 52.8 1891 316,897 156 49.2 1892 167,385 87 52.0 1892 325,128 148 45.5 1893 172,925 88 50.9 1893 335,233 171 51.0 1894 175,642 83 47.3 1894 • 1895 341,932 345,466 162 166 47.4 48.1 1895 175,901 86 48.9 1891-1895 854,803 430 50.3 1891-1895 1,664,656 803 48.2 1896 173,578 98 56.5 1896 344,810 186 53.9 1897 172,545 107 62.0 1897 344,313 185 53.7 1898 173,897 95 54.6 1898 346,854 184 53.0 1899 177,145 104 58.7 1899 1900 351,658 354,268 203 210 57.7 59.3 1900 178,729 103 57.6 1896-1900 875,894 507 57.9 1896-1900 1,741,903 968 55.Q 1901 180,003 105 58.3 1901 357,556 216 60.4 1902 177,529 126 71.0 1902 355,934 267 75.0 1903 176,254 133 75.5 1903 355,437 261 73.4 1904 176,586 112 63.4 1904 1905 356,968 359,940 226 249 63.3 69.2 1905 179,182 118 65.9 1901-1905 889,554 594 66.8 1901-1905 1,785,835 1,219 68.3 1906 182,334 139 76.2 1906 363,110 279 76.8 1907 184,864 134 72.5 1907 367,710 270 73.4 1908 190,524 139 73.0 1908 377,994 270 71.4 1909 196,553 154 78.4 1909 388,439 310 79.8 1910 201,344 158 78.5 1910 397,700 317 79.7 1906-1910 955,619 724 75.8 1906-1910 1,894,953 1,446 76.3 1911 208,923 148 70.8 1911 411,218 303 73.7 1912 214,416 173 80.7 1912 421,644 325 77.1 1913 219,605 181 82.4 1913 433,588 362 83.5 Source: Vital Statistics of South Aus- Source: Vital Statistics of South Aus- tralia. tralia. J 730 APPENDIX G Table 276 Table 277 Mortality from Cancer in South Mortality from Cancer in Qu eensland Australia, Females, 1882 -1913 Rate per 1881-] 1913 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1882 135,075 37 27.4 1881 216,445 65 30.0 1883 139,456 39 28.0 1882 232,089 54 23.3 1884 143,693 51 35.5 1883 261,472 70 26.8 1885 145,957 48 32.9 1884 291,101 94 32.3 1885 309,134 53 17.1 1882-1885 564,181 175 31.0 1881-1885 1,310,241 336 25.6 1886 146,042 58 39.7 1887 146,411 51 34.8 1886 324,496 92 28.4 1888 147,941 67 45.3 1887 342,096 81 23.7 1889 149,349 66 44.2 1888 359,523 88 24.5 1890 151,281 61 40.3 1889 374,327 130 34.7 1890 386,803 117 30.2 1 88fi-l 8Q0 741,024 303 40.9 ±OOw XOi/v* 1886-1890 1,787,245 508 28.4 1891 153,947 70 45.5 1892 157,743 61 38.7 1891 396,256 134 33.8 1893 162,308 83 51.1 1892 405,036 130 32.1 1894 166,290 79 47.5 1893 414,335 121 29.2 1895 169,565 80 47.2 • 1894 424,492 436,528 157 189 37.0 43.3 1895 18Q1-18Q5 809,853 373 46.1 x(Ji7 X X(Ji7*J 1891-1895 2,076,647 731 35.2 1896 171,232 88 51.4 1897 171,768 78 45.4 1896 447,885 183 40.9 1898 172,957 89 51.5 1897 458,000 187 40.8 1899 174,513 99 56.7 1898 469,078 229 48.8 1900 175,539 107 61.0 1899 1900 480,588 490,081 243 229 50.6 46.7 18Qfi-1QnO 866,009 461 53.2 XiJij\J l.iy\J\J 1896-1900 2,345,632 1,071 45.7 1901 177,553 111 62.5 1902 178,405 141 79.0 1901 501,432 278 55.4 1903 179,183 128 71.4 1902 510,450 285 55.8 1904 180,382 114 63.2 1903 514,483 252 49.0 1905 180,758 131 72.5 1904 1905 521,815 528,928 297 351 56.9 66.4 1901-1905 896,281 625 69.7 1901-1905 2,577,108 1,463 56.8 1906 180,776 140 77.4 1907 182,846 136 74.4 1906 536,200 292 54.5 1908 187,470 131 69.9 1907 542,730 353 65.0 1909 191,886 156 81.3 1908 553,619 337 60.9 1910 196,356 159 81.0 1909 1910 569,950 591,591 341 395 59.8 66.8 1906-1910 939,334 722 76.9 1906-1910 2,794,090 1,718 61.5 1911 202,295 155 76.6 1912 207,228 152 73.3 1911 614,352 398 64.8 1913 213,983 181 84.6 1912 631,577 399 63.2 1913 652,555 426 65.3 Source : Vital Statistics of South Aus- tralia. Source : Vital Statistics of Queensland. 731 APPENDIX G Table 278 Mortality from Cancer in Queensland, Males 1893-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 \esiT Population from 100,000 Cancer Population Cancer Population 1893 233,571 85 36.4 1906 293,645 167 56.9 1894 238.940 88 36.8 1907 295,349 204 69.1 1895 245,385 114 46.5 1908 301,323 189 62.7 1909 310,400 193 62.2 1896 250,989 107 42.6 1910 322,268 233 72.3 1897 255,887 102 39.9 1898 262,153 138 52.6 1906-1910 1,522,985 986 64.7 1899 268,767 151 56.2 1900 273,288 130 47.6 1911 334,542 242 72.3 1912 342,663 224 65.4 1896-1900 1,311,084 628 47.9 1913 353,625 252 71.3 1901 279,075 163 58.4 Source: Vital Statistics of Queensland. 1902 283,934 170 59.9 1903 285,176 156 54.7 1904 288,715 169 58.5 1905 291,149 196 67.3 59.8 1901-1905 1,428,049 854 Table 279 Mortality from Cancer in Queensland, Females 1893-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 \ear Population from 100,000 Cancer Population Cancer Population 1893 180,764 36 19.9 1906 242,555 125 51.5 1894 185,552 69 37.2 1907 247,381 149 60.2 1895 191,143 75 39.2 1908 252,296 148 58.7 1909 259,550 148 57.0 1896 196,896 76 38.6 1910 269,323 162 60.2 1897 202,113 85 42.1 1898 206,925 91 44.0 1906-1910 1,271,105 732 57.6 1899 211,821 92 43.4 1900 216,793 99 45.7 1911 279,810 156 55.8 1912 288,914 175 60.6 1896-1900 1,034,548 443 42.8 1913 298,930 174 58.2 1901 222,357 115 51.7 Source: Vital Statistics of Queensland. 1902 226,516 115 50.8 1903 229,307 96 41.9 1904 233,100 128 54.9 1905 237,779 155 65.2 53.0 1901-1905 1,149,059 609 732 APPENDIX G Table 280 Mortality from Cancer in Tasmania, 1884-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1884 124,971 65 52.0 1901 172,525 95 55.1 1885 127,763 60 47.0 1902 175,173 109 62.2 1903 180,375 100 55.4 1886 130,025 57 43.8 1904 183,007 93 50.8 1887 133,366 67 50.2 1905 184,478 97 52.6 1888 136,709 68 49.7 1889 139,769 70 50.1 1901-1905 895,558 494 55.2 1890 143,224 79 55.2 1906 184,272 94 51.0 1886-1890 683,093 341 49.9 1907 184,791 112 60.6 1908 187,485 123 65.6 1891 147,969 68 46.0 1909 190,227 124 65.2 1892 150,681 69 45.8 1910 191,005 123 64.4 1893 150,304 151,451 79 80 52.6 52.8 1894 1906-1910 937,780 576 61.4 1895 153,701 75 48.8 1911 190,316 119 62.5 1891-1895 754,106 371 49.2 1912 191,684 132 68.9 1913 195,986 144 73.5 1896 157,096 95 60.5 1897 161,629 81 50.1 Source: Statistics of Tasmania. 1898 166,200 99 59.6 Official Statistics, Commonwealth of 1899 170,400 91 53.4 Australia, Commoawealth Demography, 1900 172,631 93 459 53.9 55.4 1913. 1896-1900 827,956 Table 281 Mortality from Cancer in Tasmania, Males, 1892-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1892 79,846 34 42.6 1906 94,697 48 50.7 1893 79,267 40 50.5 1907 94,719 52 54.9 1894 79,032 46 58.2 1908 95,852 60 62.6 1895 79,885 3*2 40.1 1909 1910 97,362 97,552 55 61 56.5 62.5 18Q2-1895 318,030 152 47.8 XKl%fM~l.lJi3%J 1906-1910 480,182 276 57.5 1896 81,585 49 60.1 1897 83,919 38 45.3 1911 97,088 67 69.0 1898 86,669 52 60.0 1912 98,288 62 63.1 1899 89,262 41 45.9 1913 101,469 69 68.0 1900 90,050 51 56.6 Source: Statistics of Tasmania 1896-1900 431,485 231 53.5 Official Statistics, Commonwealth of 1901 89,719 ^8 53.5 Australia, 1913. Commonwealth Demography, 1902 91,145 58 63.6 1903 94,135 55 58.4 1904 95,303 41 43.0 1905 95,438 45 247 47.2 53.0 1901-1905 465,740 733 APPENDIX G Table 282 Table 283 Mortality from Cancer in Tasmania Mortality from Cancer in Western Females, 1892-1913 Rate per } Australia, 1881-1913 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1892 70,835 35 49.4 1881 29,859 6 20.1 1893 71,037 39 54.9 1882 30,586 9 29.4 1894 72,419 34 46.9 1883 31,551 10 31.7 1895 73,816 43 58.3 1884 32,816 10 30.5 151 52.4 1885 34,753 17 48.9 288,107 1892-1895 1881-1885. 159,565 52 32.6 1896 75,511 46 60.9 1897 77,710 43 55.3 1886 38,282 15 39.2 1898 79,531 47 59.1 1887 42,212 17 40.3 1899 81,138 50 61.6 1888 43,817 18 41.1 1900 82,581 42 50.9 1889 44,737 20 44.7 228 57.5 1890 1886-1890 47,081 15 85 31.9 396,471 1896-1900 216,129 39.3 1901 1902 1903 1904 1905 82,806 84,028 86,240 87,704 89,040 47 51 45 52 52 247 56.8 60.7 52.2 59.3 58.4 57.5 1891 1892 1893 1894 1895 1891-1895 50,840 55,873 61,746 73,251 91,047 20 16 19 22 25 102 39.3 28.6 30.8 30.0 27.5 429,818 1901-1905 332,757 30.7 1906 89,575 46 51.4 1896 118,666 30 25.3 1907 90,072 60 66.6 1897 148,656 51 34.3 1908 91,633 63 68.8 1898 163,687 55 33.6 1909 92,865 69 74.3 1899 168,568 60 35.6 1910 93,453 62 300 66.3 65.6 1900 1896-1900 175,113 52 248 29.7 1906-1910 457,598 774,690 32.0 1911 93,228 52 55.8 1901 188,135 83 44.1 1912 93,396 70 74.9 1902 204,705 85 41.5 1913 94,517 75 79.4 1903 219,643 92 41.9 1904 233,963 105 44.9 Source: Statistics of Tasmania 1905 246,681 127 51.5 Official Statistics r"r,mmrvnwealt>i r.f Australia, Commonwealth Demography, 1901-1905 1,093,127 492 45.0 1913. 1906 254,362 154 60.5 1907 255,510 131 51.3 1808 257,822 140 54.3 1909 263,279 182 69.1 1910 1906-1910 271,019 135 742 49.8 1,301,992 57.0 1911 286,807 177 61.7 1912 301,426 180 59.7 1913 314,178 178 56.7 Source: Statistical Register of Western Australia. 734 APPENDIX G Table 284 Mortality from Cancer in Western Australia, Males, 1897-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1897 102,327 37 36.2 1906 148,501 91 61.3 1898 107,62-i 39 36.2 1907 147,641 79 53.5 1899 107,204 41 38.2 1908 147,918 77 52.1 1900 108,452 33 30.4 1909 150,400 97 64.5 1910 154,467 74 47.9 1897-1900 425,607 150 35.2 1906-1910 748,927 418 55.8 1901 115,080 53 46.1 1902 124,839 46 36.8 1911 164,136 109 66.4 1903 132,272 44 33.3 1912 172,098 106 61.6 1904 139,338 61 43.8 1913 178,265 92 51.6 1905 145,471 74 50.9 Source: Statistical Register of Westera 1901-1905 657,000 278 42.3 Australia. Table 285 Mortality from Cancer in Western Australia, Females, 1897-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1897 46,329 14 30.2 1906 105,861 63 59.5 1898 56,063 16 28.5 1907 107,869 52 48.2 1899 61,364 19 31.0 1908 109,904 63 57.3 1900 66,661 19 28.5 1909 112,879 85 75.3 1910 116,552 61 52.3 1897-1900 230,417 68 29.5 1906-1910 553,065 324 58.6 1901 73,055 30 41.1 1902 79,866 39 48.8 1911 122,671 68 55.4 1903 87,371 48 54.9 1912 129,328 74 57.2 1904 f 94,625 44 46.5 1913 135,913 86 63.3 1905 101,210 53 52.4 Source: Statistical Register of Western 1901-1905 436,127 214 49.1 Australia. Table 286 Mortality from Cancer, Northern Territory, Commonwealth of Australia 1911-1913 Year Population Deaths from Cancer Rate per 100,000 Population 1911 3,319 1 30.1 1912 3,359 2 59.5 1913 3,360 2 5 54.6 11-1913 10,038 49.8 Source: Official Statistics, Common- wealth of Australia, Commonwealth De- mography, 1911-1913. 735 APPENDIX G Table 287 Table 288 Mortality from Cancer in New Zea- Mortality from Cancer in New Zea- land, 1881 -1913 Deaths Rate per la Qd, Males, 1889-1913 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 493,482 134 27.2 1889 325,249 144 44.3 1882 509,309 147 28.9 1890 330,069 156 47.3 1883 529,292 158 29.9 1884 552,590 191 34.6 1891 334,366 154 46.1 1885 573,362 177 30.9 1892 340,660 173 50.8 1893 1894 351,391 360,699 188 240 53.5 66.5 1881-1885 2,658,035 807 30.4 1886 582,117 214 36.8 1895 366,744 208 56.7 1887 596,374 238 39.9 1891-1895 1,753,860 963 54.9 1888 605,371 263 43.4 1889 611,716 260 42.5 1896 373,238 205 54.9 1890 620,780 295 47.5 1897 380,845 210 55.1 1898 1899 388,414 395,402 263 271 67.7 68.5 1886-1890 3,016,358 1,270 42.1 1900 402,118 246 61.2 1891 629,783 642,245 295 46.8 1892 307 47.8 1896-1900 1,940,017 1,195 61.6 1893 661,349 332 50.2 1894 679,196 408 60.1 1901 408,926 265 64.8 1895 692,417 383 55.3 1902 420,065 296 70.5 1903 432,791 325 75.1 1891-1895 3,304,990 1,725 52.2 1904 446,833 323 72.3 1905 460,679 313 67.9 1896 706,846 721,609 389 55.0 1897 395 54.7 1901-1905 2,169,294 1,522 70.2 1898 736,260 471 64.0 1899 749,984 468 62.4 1906 474,509 337 71.0 1900 763,594 430 56.3 1907 487,150 361 74.1 1908 501,489 363 72.4 1896-1900 3,678,293 2,153 58.5 1909 515,368 389 74.3 1901 777,968 797,793 820,217 515 536 582 66.2 67.2 71.0 1910 1906-1910 525,167 399 76.0 1902 1903 2,503,683 1,843 73.6 1904 845,022 571 67.6 1911 534,863 448 83.8 1905 870,000 566 65.1 67.4 1912 1913 546,873 561,160 418 446 76.4 1901-1905 4,111,000 2,770 79.5 1906 895,594 623 69.6 Source: Statistics of the Colony of New 1907 919,105 674 73.3 Zealand. 1908 945,063 657 69.5 1909 971,784 711 73.2 1910 992,802 742 74.7 72.1 1906-1910 4,724,348 3,407 1911 1,014,896 809 79.7 1912 1,039,017 812 78.2 1913 1,068,644 854 79.9 Source: Statistics of the Colony of New Zealand. 736 APPENDIX G Table 289 Mortality from Cancer in New Zealand, Females 1889-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1889 286,467 116 40.5 1906 421,085 286 67.9 1890 290,711 139 47.8 1907 431,955 313 72.5 1908 443,574 294 66.3 1891 295,417 141 47.7 1909 456,416 328 71.9 1892 301,585 134 44.4 1910 467,635 343 73.3 1893 309,958 144 46.5 1894 318,497 168 52.7 1906-1910 2,220,665 1,564 70.4 1895 325,673 175 53.7 1911 480,033 361 75.2 1891-1895 1,551,130 762 49.1 1912 492,144 394 80.1 1913 507,484 408 80.4 1896 333,608 184 55.2 1897 340,764 185 54.3 Source : Statistics of the Colony of 1898 347,846 208 59.8 New Zealand. 1899 354,582 197 55.6 1900 361,476 184 50.9 55.1 1896-1900 1,738,276 958 1901 369,042 250 67.7 1902 377,728 240 63.5 1903 387,426 257 66.3 1904 398,189 248 62.3 1905 409,321 253 61.8 64.3 1901-1905 1,941,706 1,248 Table 290 Cases of Cancer in the Colonial Hospital, Fiji 1898-1911 Rate per Rate per Total Cases of 1,000 Total Cases of 1,000 Year Admissions Cancer Admissions Year Admissions Cancer Admissions 1898 1,147 2 1.7 1906 1,356 8 5.9 1899 1,407 5 3.6 1907 1,731 4 2.3 1900 1,427 8 5.6 1908 1,627 9 5.5 1909 1,810 8 4.4 1898-1900 3,981 1,222 15 2 3.8 1.6 1911 1906-1911* 2,120 7 3.3 1901 8,644 36 4.2 1902 1,272 4 3.1 1903 1,773 13 7.3 Source: Fiji, Annual Medical Reports. 1904 1,485 19 12.8 *Data for 1910 unobtainable 1905 1,398 8 46 5.7 6.4 1901-1905 7,150 737 APPENDIX G Table 291 Cases of Cancer in the Colonial Hospital, Fiji, by Organs and Parts 1905-1911* Carcinoma of Cases ffisophagus 1 Stomach 3 Pylorus 5 Pancreas 1 Liver 8 Gall-bladder 2 Intestines 1 Rectum 2 Prostate 1 Breast 1 Uterus 8 Other or not specified 2 Epithelioma 4 Sarcoma 5 AH organs 44 Source: Fiji, Annual Medical Reports. *Data for 1910 unobtainable. Per Cent. 2.3 6.8 11.4 2.3 18.2 4.5 2.3 4.5 2.3 2.3 18.2 4.5 9.0 11.4 100.0 Table 292 Cases of Cancer in thie Colonial Hospital, Fiji, by Race 1906-1911* Rate per Total Cases of 1,900 Admissions Cancer Admissions Europeans 845 8 9.5 Fijians 2,991 4 1.3 Polynesians 825 1 1.2 East Indians 3,838 20 5.2 Miscellaneous 313 3 9.6 Total 8,812 36 4.1 Source: Fiji, Annual Medical Reports. Note: The number of admissions given above includes 168 admissions from previous years. *Data for 1910 unobtainable. 738 APPENDIX G Table 293 Mortality from Cancer in Hawaii 1902-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1902 161,581 22 13.6 1906 176,745 44 24.9 1903 165,372 38 23.0 1907 180,536 47 26.0 1904 169,163 41 24.2 1908 184,327 58 31.5 1905 172,954 44 25.4 1909 188,118 69 36.7 1910 193,014 95 49 2 1902-1905 669,070 145 21.7 1906-1910 922,740 313 33.9 1911 196,805 99 50.3 1912 200,596 71 35.4 1913 217,744 100 45.9 Source: Report of the President of the Board of Health of the Territory of Hawaii. Table 294 Mortality from Cancer in the Territory of Hawaii, by Race July 1, 1911, to June 30, 1913 Race Population Hawaiian 54,386 Part Hawaiian 26,131 Portuguese 46,571 Chinese 45,268 Japanese 166,404 All others 62,020 Total 400,780 Source: Annual Reports of the Registrar-General of Hawaii. Deaths from Cancer 51 7 27 12 33 23 153 Rate per 100,000 Population 93.8 26.8 58.0 26.5 19.8 37.1 38.2 Table 295 Proportionate Mortality from Cancer in the Territory of Hawaii according to Race, by Organs and Parts July 1, 1911, to June 30, 1913 Haw AIIANS Portuguese Chinese Japanese Organ or Part Deaths Per Cent. Deaths Per Cent. Deaths Per Cent. Deaths Per Cent. Breast 7 13.7 1 3.7 0.0 0.0 Face 0.0 0.0 1 8.3 0.0 Intestines ... 1 2.0 0.0 0.0 4 12.1 Liver 5 9.8 4 14.8 1 8.3 1 3.0 Stomach ... 14 27.5 11 40.8 6 50.0 19 57.6 Uterus ... 15 29.4 2 7.4 2 16.7 6 18.2 Other organs .... 9 ... 51 17.6 9 33.3 2 12 16.7 3 9.1 All organs 100.0 27 100.0 100.0 33 100.0 Source: Annual Reports of the Registrar-General of Hawaii. 739 APPENDIX G Table 296 Mortality from Cancer in Countries of America Deaths Rate per Population from 100,000 Cancer Population Argentina 17,807,056 11,392 64.0 Bermuda 92,780 52 56.0 Bolivia 316,090 69 21.8 Brazil 9,384,279 3,145 33.5 British Guiana 1,487,922 271 18.2 British Honduras 197,820 29 14.7 British West Indies 6,897,104 1,439 20.9 Canada 19,689,825 12,208 62.0 Chile 17,047,786 6,077 35.6 Colombia 242,986 218 89.7 Costa Rica 1,849,534 751 40.6 Cuba 10,892,077 4,855 44.6 Danish West Indies 53,393 63 118.0 Dutch Guiana 174,775 167 95.6 Ecuador 200,000 122 61.0 Mexico 2,355,330 1,165 49.5 Newfoundland 1,192,843 616 51.6 Nicaragua 2,180,000 231 10.6 Peru 170,000 202 118.8 Salvador 357,240 208 58.2 United States 271,207,437 202,621 74.7 Uruguay 5,421,854 3,577 66.0 Venezuela 13,331,180 1,960 14.7 Total 382,549,311 251,438 65.7 Population, 1911: 82,835,662. Note: Argentina Province of Buenos Aires, 1908-1912, City of Buenos Aires, 1907, 1911, City of Rosario de Santa Fe, 1907-1911, Province of Tucu- man, 1906-1910, City of Santiago del Estero, 1904-1908 Bermuda 1906-1910 Bohvia City of La Paz, 1901-1905 Brazil Federal District of Rio de Janeiro, 1906-1910, State of Parana, 1906 1910, City of Bahia, 1907-1911, City of Sao Paulo, 1908- 1912, City of Pelotas, 1906-1907, 1909-1911, City of Belle Horizonte, 1910-1912 British Guiana 1908-1912 British Honduras 1906-1910 British West Indies .. Jamaica, 1908-1912, Trinidad, 1907-1911, British Windward and Leeward Islands, 1907-1911 Canada Province of Ontario, 1908-1912, Province of Nova Scotia, 1910- 1913, Province of Prince Edward Island, 1913, Province of British Columbia, 1909-1913, City of Montreal, 1908-1912, City of Quebec, 1908-1912, City of Wimiipeg, 1910-1912, City of St. John, N. B., 1908-1912 Chile 1908-1912 Colombia City of Bogota, 1912-1913 Costa Rica 1908-1912 Cuba 1908-1912 Danish West Indies. .Island of St. Thomas, 1909-1913 Dutch Guiana City of Paramaribo, 1908-1912 Ecuador City of Guayaquil, 1910-1912 Mexico City of Mexico, 1908-1912 Newfoundland 1907-1911 Nicaragua 1908-1911 Salvador City of San Salvador, 1908-1913 Peru City of Lima, 1904, City of Trujillo, 1909-1913 United States Registration Area, 1908-1912 Uruguay 1907-1911 Venezuela 1906-1910 740 APPENDIX G Table 297 Table 298 Mortality from Cancer in the Prov- Mortality from Cancer in Toronto ince of Ontario, Canada Province of Ontario 1881-1913 Rate per 1881-1913 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 1,923,228 313 16.3 1881 86,415 23 26.6 1882 1,942,337 397 20.4 1882 92,175 25 27.1 1883 1,961,446 403 20.5 1883 97,935 24 24.5 1884 1,980,555 422 21.3 1884 103,696 37 35.7 1885 1,999,664 463 23.2 20.4 1885 1881-1885 109,457 49 44.8 1881-1885 9,807,230 1,998 489,678 158 32.3 1886 2,018,773 440 21.8 1886 115,218 55 47.7 1887 2,037,882 614 30.1 1887 120,979 59 48.8 1888 2,056,991 635 30.9 1888 126,740 76 60.0 1889 2,076,100 714 34.4 1889 132,501 93 70.2 1890 2,095,209 685 32.7 30.0 1890 1886-1890 138,262 78 56.4 1886-1890 10,284,955 3,088 633,700 361 57.0 1891 2,114,321 579 27.4 1891 144,023 74 51.4 1892 2,121,183 676 31.9 1892 150,424 87 57.8 1893 2,128,045 678 31.9 1893 156,825 106 67.6 1894 2,134,907 621 29.1 1894 163,226 85 52.1 1895 2,141,769 620 28.9 29.8 1895 1891-1895 169,628 112 66.0 1891-1895 10,640,225 3,174 784,126 464 59.2 1896 2,148,632 731 34.0 1896 176,030 116 65.9 1897 2,155,495 927 43.0 1897 182,432 114 62.5 1898 2,162,358 975 45.1 1898 188,834 129 68.3 1899 2,169,221 1,041 48.0 1899 195,236 134 68.6 1900 2,176,084 1,055 48.5 43.7 1900 1896-1900 201,638 171 84.8 1896-1900 10,811,790 4,729 944,170 664 70.3 1901 2,182,947 1,094 50.1 1901 208,040 163 78.4 1902 2,216,979 1,048 47.3 1902 224,889 133 59.1 1903 2,251,011 1,156 51.4 1903 241,738 157 64.9 1904 2,285,043 1,253 54.8 1904 258,588 187 72.3 1905 2,319,076 1,224 52.8 51.3 1905 1901-1905 275,438 191 69.3 1901-1905 11,255,056 5,775 1,208,693 831 68.8 1906 2,353,109 1,411 60.0 1906 292,288 187 64.0 1907 2,387,142 1,329 55.7 1907 309,138 204 66.0 1908 2,421,175 1,348 55.7 1908 325,988 203 62.3 1909 2,455,208 1,597 65.0 1909 342,838 259 75.5 1910 2,489,241 1,587 63.8 60.1 1910 1906-1910 359,688 270 75.1 1906-1910 12,105,875 7,272 1,629,940 1,123 68.9 1911 2,523,274 1,602 63.5 1911 376,538 255 67.7 1912 2,560,000 1,778 69.5 1912 393,388 326 82.9 1913 2,600,960 1,806 69.4 1913 410,238 336 81.9 Source: Reports Relating to the Regis- Source: Reports Relating to the Regis- tration of Births, Marriages and Deaths tration of Births, Marriages and Deaths in the Province of Ontario, 1881-1913. in the Province of Ontario, 1881-1913. 741 APPENDIX G Table 299 Table 300 Mortality from Cancer in Toronto Mortality from Cancer in Toronto ] Males, 1881- -1913 Deaths Rate per I "emales, 1881-1913 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 41,917 8 19.1 1881 44,498 15 33.7 1882 44,696 14 31.3 1882 47,479 11 23.2 1883 47,469 15 31.6 1883 50,466 9 17.8 1884 50,241 14 27.9 1884 53,455 23 43.0 1885 53,010 22 73 41.5 30.8 1885 1881-1885 56,447 27 85 47.8 1881-1885 237,333 252,345 33.7 1886 55,777 22 39.4 1886 59,441 33 55.5 1887 58,542 25 42.7 1887 62,437 34 54.5 1888 61,291 35 57.1 1888 65,449 41 62.6 1889 64,038 34 53.1 1889 68,463 59 86.2 1890 66,781 29 145 43.4 47.3 1890 1886-1890 71,481 49 216 68.5 1886-1890 306,429 327,271 66.0 1891 69,520 33 47.5 1891 74,503 41 55.0 1892 72,384 28 38.7 1892 78,040 59 75.6 1893 75,213 45 59.8 1893 81,612 61 74.7 1894 78,022 26 33.3 1894 85,204 59 69.2 1895 80,811 49 181 60.6 48.1 1895 1891-1895 88,817 63 283 70.9 1891-1895 375,950 408,176 69.3 1896 83,579 55 65.8 1896 92,451 61 66.0 1897 86,327 44 51.0 1897 96,105 70 72.8 1898 89,054 62 69.6 1898 99,780 67 67.1 1899 91,761 53 57.8 1899 103,475 81 78.3 1900 94,447 65 279 68.8 62.7 1900 1896-1900 107,191 106 385 98.9 1896-1900 445,168 499,002 77.2 1901 97,113 60 61.8 1901 110,927 103 92.9 1902 105,585 52 49.2 1902 119,304 81 67.9 1903 114,149 68 59.6 1903 127,589 89 69.8 1904 122,803 71 57.8 1904 135,785 116 85.4 1905 131,549 84 335 63.9 58.6 1905 1901-1905 143,889 107 496 74.4 1901-1905 571,199 637,494 77.8 1906 140,386 76 54.1 1906 151,902 111 73.1 1907 149,314 80 53.6 1907 159,824 124 77.6 1908 158,332 78 49.3 1908 167,656 125 74.6 1909 167,442 123 73.5 1909 175,396 136 77.5 1910 176,643 119 476 67.4 60.1 1910 1906-1910 183,045 151 647 82.5 1906-1910 792,117 837,823 77.2 1911 185,934 99 53.2 1911 190,604 156 81.8 1912 194,257 130 66.9 1912 199,131 196 98.4 1913 202,575 129 63.7 1913 207,663 207 99.7 Source: Reports Relating to the Regis- Source: Reports Relating to the Regis- tration of Births, Marriages and Deaths tration of Births, Marriages and Deaths in the Province of Ontario, 1881 -1913. in the Province of Ontario, 1881- 1913. 742 APPENDIX G Table 301 Mortality from Cancer in the City of Montreal 1881-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 115,238 46 • 39.9 1906 369,105 213 57.7 1882 125,675 65 51.7 1907 389,380 234 60.1 1883 136,112 63 46.3 1908 409,655 230 56.1 1884 146,550 59 40.3 1909 429,930 267 62.1 1885 156,988 79 50.3 45.8 1910 1906-1910 450,205 292 64.9 1881-1885 680,563 312 2,048,275 1.236 60.3 1886 167,426 85 50.8 1911 470,480 309 65.7 1887 177,864 75 42.2 1912 488,400 331 67.8 1888 188,302 87 46.2 1913 515,700 283 54.9 1889 198,740 97 48.8 1890 209,178 74 35.4 Source: 1881-1890, Statistique Demo- graphique des Grandes Villes d i\/f" J \i Monde, 1886-1890 941,510 418 44.4 No. 40. Amsterdam, 1912. Reports on the Sanitary State of the 1891 219,616 99 45.1 City of Montreal, 1891-1913. 1892 224,427 109 48.6 1893 229,238 100 43.6 1894 234,049 114 48.7 1895 238,860 117 49.0 47.0 1891-1895 1,146,190 539 1896 243,672 133 54.6 1897 1898 253,296 182 71.9 1899 258,108 190 73.6 1900 262,920 146 55.5 63.9 1896-1900 1,017,996 651 1901 267,730 196 73.2 1902 288,005 158 54.9 ^ 1903 308,280 206 66.8 1904 328,555 180 54.8 1905 348,830 167 47.9 58.8 1901-1905 1,541,400 907 743 APPENDIX G Table 302 Mortality from Cancer in the City of Quebec 1894-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1894 64,815 28 43.2 1906 72,034 25 34.7 1895 65,390 16 24.5 1907 74,390 39 52.4 1908 73,333 33 45.0 1896 65,965 20 30.3 1909 76,000 42 55.3 1897 66,540 23 34.6 1910 77,100 44 57.1 1898 67,115 32 47.7 1899 67,690 27 39.9 1906-1910 372,857 183 49.1 1900 68,265 34 49.8 IQIl 78,190 79,280 'l^ 65.2 56.8 1896-1900 335,575 136 40 5 li7 JL L 1912 \j ± 45 1901 68,840 38 55.2 Source: Annual Reports of the Board of 1902 69,595 44 63.2 Health of the Province of Quebec. 1903 70,204 38 54.1 1904 70,819 31 43.8 1905 71,439 30 181 42.0 51.6 1901-1905 350,897 Table 303 Mortality from Cancer in the City of Winnipeg, by Sex 1910-1913 TOTAL ]MALES Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1910 127,555 64 50.2 1910 69,773 36 51.6 1911 142.339 71 49.9 1911 77,859 31 39.8 1912 159,256 82 51.5 1912 87,113 39 44.8 1913 177,433 95 312 53.5 51.4 1913 1910-1913 97,056 46 152 47.4 1910-1913 606,583 331,801 45.8 FEMi ^ES Year Population Deaths from Cancer Ratetper 100,000 Population 1910 57,782 28 48.5 1911 64,480 40 62.0 1912 72,143 43 59.6 1913 1910-1913 80,377 49 160 61.0 58.2 274,782 Source: City of Winnipeg, Report of the Department of Pubhc Health, 1910- 1913. 744 APPENDIX G Table 304 Mortality from Cancer in British Columbia, 1901-1913 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1901 1902 1903 1904 1905 175,657 197,340 219,023 240,706 262,388 49 81 73 66 63 332 27.9 41.0 33.3 27.4 24.0 30.3 1906 1907 1908 1909 1910 1906-1910 284,070 305,752 327,434 349,116 370,798 71 101 99 123 152 546 25.0 33.0 30.2 35.2 41.0 1901-1905 1,095,114 1,637,170 33.4 1911 1912 1913 392,480 414,162 435,844 148 180 159 37.7 43.5 36.5 Source: Annual Reports of the Regis- trar of Births, Deaths and Marriages for the Province of British Columbia. Table 305 Mortality from Cancer in the Prov- ince of Nova Scotia, by Sex 1910-1913 TOTAL Deaths Rate per Year Population from 100,000 Cancer Population 1910 486,870 349 71.7 1911 492,338 371 75.4 1912 496,423 378 76.1 1913 501,751 348 69.4 10-1913 1,977,382 MALES 1,446 73.1 1910 248,304 170 68.5 1911 251,019 179 71.3 1912 253,176 171 67.5 1913 255,893 159 62.1 1910-1913 1,008,392 679 FEMALES 1910 1911 1912 1913 238,566 241,319 243,247 245,858 179 192 207 189 1910-1913 968,990 767 67.3 75.0 79.6 85.1 76.9 79.2 Source: Reports of the Deputy Regis- trar-General Relating to the Registration of Births, Marriages and Deaths in Nova Scotia, 1910-1913. Table 306 Mortality from Cancer in the Province of Prince Edward Island 1913-1914 Year Population Deaths from Cancer Rate per 100,000 Population 1913 92,000 54 58.7 1914 90,631 46 100 50.8 1913-1914 182,631 54.7 Source: Report of the Registrar- General of Births, Marriages and Deaths of the Province of Prince Edward Island. 745 APPENDIX G Table 307 Mortality from Cancer in the City of St. John, Province of New Brunswick 1891- 1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 39,179 9 23.0 1906 41,611 37 88.9 1892 39,332 18 45.8 1907 41,791 34 81.4 1893 39,485 15 38.0 1908 41,971 29 69.1 1894 39,638 26 65.6 1909 42,151 32 75.9 1895 39,791 32 100 80.4 50.7 1910 1906-1910 4.2,331 36 168 85.0 1891-1895 197,425 209,855 80.1 1896 39,944 32 80.1 1911 42,511 36 84.7 1897 40,097 29 72.3 1912 42,691 40 93.7 1898 40,250 35 87.0 1913 42,871 38 88.6 1899 40,403 24 59.4 1900 40,556 38 93.7 Source: Annual Reports of the Provincial Board of Health of New Brunswick. 1896-1900 201,250 158 78.5 1901 40,711 44 108.1 1902 40,891 37 90.5 1903 41,071 37 90.1 1904 41,251 39 94.5 1905 41,431 43 200 103.8 97.4 1901-1905 205,355 Table 308 Mortality from Cancer in the Colony of Newfoundland and Labrador 1906-1913 Year 1906 1907 1908 1909 1910 Population 231,974 234,172 236,370 238,568 240,767 1906-1910 1,181,851 595 1911 242,966 137 1912 243,928 118 1913 246,397 111 Rate per 100,000 Population 50.0 47.0 55.8 51.6 47.3 50.3 56.4 48.4 45.0 Source: Annual Reports of the Regis- trar-General of Births, Marriages and Deaths of Newfoundland for 1906-1913. 746 APPENDIX G Table 309 Mortality from Cancer in the Bermuda Islands, 1891-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 15,013 6 40.0 1906 18,264 11 60.2 1892 15,265 14 91.7 1907 18,410 8 43.5 1893 15,517 8 51.6 1908 18,556 10 53.9 1894 15,769 10 63.4 1909 18,702 16 85.6 1895 16,021 5 43 31.2 55.4 1910 1906-1910 18,848 7 52 37.1 1891-1895 77.585 92,780 56.0 1896 16,273 9 55.3 1911 18,994 6 31.6 1897 16,525 4 24.2 1912 19,392 12 61.9 1898 16,777 13 77.5 1913 19,790 13 65.7 1899 17,029 12 70.5 1900 17,281 13 75.2 Source: Bermuda, Reports of the Regis- froT- noncTol 1C01 lOia 1896-1900 83,885 51 60.8 Lrar-vieiier a.1, njn i.-i~a i.%j. 1901 17,535 9 51.3 1902 17,680 9 50.9 1903 17,826 11 61.7 1904 17,972 15 83.5 1905 18,118 12 56 66.2 62.8 1901-1905 89,131 Table 310 Mortality from Cancer in the Bermuda Islands, Males, 1891-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 7,036 2 28.4 1906 8,840 4 45.2 1892 7,193 3 41.7 1907 8,886 4 45.0 1893 7,350 3 40.8 1908 8,932 3 33.6 1894 7,507 3 40.0 1909 8,978 7 78.0 1895 7,664 1 12 13.0 32.7 1910 1906-1910 9,024 3 21 33.2 1891-1895 36,750 44,660 47.0 1896 7,821 3 38.4 1911 9,070 4 44.1 1897 7,978 1 12.5 1912 9,283 6 64.6 1898 8,135 4 49.2 1913 9,497 6 63.2 1899 8,292 4 48.2 1900 8,449 3 35.5 Source: Bermuda, Reports of the Regis- trar-General, 1891-1913. 1896-1900 40,675 15 36.9 1901 8,606 3 34.9 1902 8,656 4 46.2 1903 8,702 3 34.5 1904 8,748 7 80.0 1905 8,794 5 22 56.9 50.6 1901-1905 43,506 747 APPENDIX G Table 311 Table 312 Mortality from Cancer in the Ber- Mortality from Cancer in Jamaica muda Islands, Females 1881-1913 l»Vl-lVliJ X^eatns Rate per 100,000 Population Year Population Deaths from Rate per 100,000 Year Population from Cancer Cancer Population 1881 580,804 57 9.8 1891 7,977 4 50.1 1882 688,718 43 7.3 1892 8,072 11 136.3 1883 594,023 65 10.9 1893 8,167 5 61.2 1884 591,819 66 11.2 1894 8,262 8,357 7 4 84.7 47.9 1885 596,383 64 10.7 1895 1881-188') 2,951,747 295 10.0 1891-1895 40,835 31 75.9 XOOAXOOi^ 1886 603,354 65 10.8 1896 8,452 6 71.0 1887 603,500 61 10.1 1897 8,547 3 35.1 1888 613,376 73 11.9 1898 8,642 9 104.1 1889 624,105 70 11.2 1899 8,737 8,832 8 10 91.6 113.2 1890 634,930 80 12.6 1900 1886-1890 3,079,265 349 11.3 1896-1900 43,210 36 83.3 iOOUAtJCV 1891 636,559 91 14.3 1901 8,929 6 67.2 1892 643,407 88 13.7 1902 9,024 5 55.4 1893 651,615 96 14.7 1903 9,124 8 87.7 1894 661,046 102 15.4 1904 9,224 9,324 8 7 86.7 75.1 1895 670,383 115 17.2 1905 18Q1-18Q5 3,263,010 492 15.1 1901-1905 45,625 34 74.5 j.O(7x xijiytj 1896 679,198 113 16.6 1906 9,424 7 74.3 1897 688,534 97 14.1 1907 9,524 4 42.0 1898 698,133 109 15.6 1908 9,624 7 72.7 1899 708,106 129 18.2 1909 9,724 9,824 9 4 92.6 40.7 1900 718,783 124 17.3 1910 18Q6-1900 3,492,754 572 16.4 1906-1910 48,120 31 64.4 ±Oi7\M ±i7\J\I 1901 729,093 118 16.2 1911 9,924 2 20.2 1902 739,970 109 14.7 1912 10,109 6 59.4 1903 752,630 125 16.6 1913 10,293 7 68.0 1904 1905 764,081 773,517 128 153 16.8 19.8 Source: Bermuda, Reports of the Regis- trar-General, 1891-1913. 1901-1905 3,759,291 633 16.8 1906 781,779 141 18.0 1907 791,373 126 15.9 1908 796,862 136 17.1 1909 803,867 149 18.5 1910 • 814,987 169 721 20.1 1906-1910 3,988,868 18.1 1911 826,078 142 17.2 1912 888,575 153 18.2 1913 851,072 157 18.4 Source: Jamaica, Annual Reports of the Registrar-General. 748 APPENDIX G Table 313 Table 314 Mortality from Cancer in Jamaica Mortality from Cancer in Jamaica Males, 1881 -1913 Deaths Rate per Females, 1881-1913 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1881 277,857 21 7.6 1881 302,947 36 11.9 1882 281,643 17 6.0 1882 307,075 26 8.5 1883 284,181 21 7.4 1883 309,842 44 14.2 1884 283,126 28 9.9 1884 308,693 38 12.3 1885 285,310 21 108 7.4 7.6 1885 1881-1885 311,073 43 187 13.8 1881-1885 1,412,117 1,539.630 12.1 1886 288,645 24 8.3 1886 314,709 41 13.0 1887 288,714 17 5.9 1887 314,786 44 14.0 1888 293,439 26 8.9 1888 319,937 47 14.7 1889 298,572 22 7.4 1889 325,533 48 14.7 1890 89 7.6 1890 1886-1889 180 1886-1889 1,169,370 1,274,965 14.1 1891 304,530 26 8.5 1891 332,029 65 19.6 1892 307,806 27 8.8 1892 335,601 61 18.2 1893 311,733 33 10.6 1893 339,882 63 18.5 1894 316,244 32 10.1 1894 344,802 70 20.3 1895 320,711 40 158 12.5 10.1 1895 1891-1895 349,672 75 334 21.4 1891-1895 1,561,024 1,701,986 19.6 1896 324,928 42 12.9 1896 354,270 71 20.0 1897 329,395 37 11.2 1897 359,139 60 16.7 1898 333,987 45 13.5 1898 364,146 64 17.6 1899 338,758 33 9.7 1899 369,348 96 26.0 1900 343,866 50 207 14.5 12.4 1900 1896-1900 374,917 74 365 19.7 1896-1900 1,670,934 1,821,820 20.0 1901 348,798 31 8.9 1901 380,295 87 22.9 1902 354,002 35 9.9 1902 385,968 74 19.2 1903 359,983 37 10.3 1903 392,647 88 22.4 1904 365,460 46 12.6 1904 398,621 82 20.6 1905 369,896 47 196 12.7 10.9 1905 1901-1905 403,621 106 437 26.3 1901-1905 1,798,139 1,961,152 22.3 1906 373,847 48 12.8 1906 407,932 93 22.8 1907 378,435 40 10.6 1907 412,938 86 20.8 1908 380,980 39 10.2 1908 415,882 97 23.3 1909 384,329 45 11.7 1909 419,538 104 24.8 1910 389,645 55 227 14.1 11.9 1910 1906-1910 425,342 114 494 26.8 1906-1910 1,907,236 2,081,632 23.7 1911 394,865 5Q 14.2 1911 431,213 86 19.9 1912 400,839 55 13.7 1912 437,736 98 22.4 1913 406,813 58 14.3 1913 444,259 99 22.3 Source: Jamaica, Ann ual Reports of the Source: Jamaica, Annual Reports of the Registrar-General. Registrar-General. 749 APPENDIX G Table 315 Table 316 Mortality from Cancer in the Mortality from Cancer in Trinidad Windward and Leeward Islands 1890-1913 British West Indies 1901-1912 Deaths Rate per Year Population from 100,000 Deaths Rate per Cancer Population Year Population from Cancer 100,000 Population 1890 196,510 25 12.7 1901 110,214 .26 23.6 1891 201,200 7 3.5 1902 110,350 25 22.7 1892 206,220 25 12.1 1903 110,448 23 20.8 1893 211,301 30 14.2 1901, 200,420 49 24.4 1894 216,508 38 17.6 1905 237,254 83 206 35.0 26.8 1895 1891-1895 221,842 20 120 9.0 1901-1905 768,686 1,057,071 11.4 1906 237,896 70 29.4 1896 227,309 23 10.1 1907 238,344 57 23.9 1897 232,909 23 9.9 1908 238,865 64 26.8 1898 238,648 18 7.5 1909 239,239 61 25.0 1899 264,630* 33 12.5 1910 239,930 54 306 22.5 25.6 1900 1896-1900 269,893 42 139 15.6 1906-191C 1,194,274 1,233,389 11.3 1911 240,586 64 26.6 1901 275,261 32 11.6 1912 237,041 80 33.7 1902 282,125 47 16.7 1903 287,737 47 16.3 Source : The Registrar-General's Re- 1904 293,460 38 12.9 ports of the several above-mentioned Includes St. Kitts-Ne^^s, 1901- 1905 1901-1905 299,296 79 243 26.4 islcincls. Note: 1,437,879 16.9 1912, Grenada, 1901-1912, St. Lucia, 1904- 1912, St. Vincent, 1904-1912, Antigua and 1906 305,249 68 22.3 Barbuda, 1905-1912. 1907 311,321 81 26.0 1908 317,513 50 15.7 1909 323,828 61 18.8 1910 1906-1910 330,270 71 331 21.5 1,588,181 20.8 1911 336,839 88 26.1 1912 343,408 101 29.4 1913 348,958 120 34.4 Source: Annual Reports of the Regis- trar-General on the Vital Statistics, Trinidad. Tobago is not included previously to 1899. 750 APPENDIX G Table 317 Mortality from Cancer in the Hospitals of Barbados 1899-1903 Deaths Deaths from All from Cancer Year Causes Cancer Per Cent. 1899 860 24 2.8 1900 782 27 3.5 1901 985 29 2.9 1902 857 19 2.2 1903 712 21 2.9 1899-1903 4,196 120 2.9 Source: Correspondence relating to the Cancer Research Scheme, London, 1906. Table 318 Table 319 Mortality from Cancer in St.Thomas Mortality from Cancer in British Danish West Indies Honduras, 1894- ■1913 1901- 1914 Deaths Rate per Year Population from 100,000 Year Population Deaths from Rate per 100,000 Cancer Population Cancer Population 1894 33,272 3 9.0 1901 11,012 6 54.5 1895 33,873 3 8.9 1902 10,978 6 54.7 1903 10,944 6 54.8 1896 34,474 6 17.4 1904 10,910 18 165.0 1897 35,075 1 2.9 1905 10,876 7 64.4 1898 1899 35,676 36,277 6 4 16.8 11.0 1901-1905 54,720 10,843 43 1 78.6 9.2 1900 1896-1900 36,878 7 24 19.0 1906 178,380 13.5 1907 10,810 12 111.0 1908 10,777 4 37.1 1901 37,479 10 26.7 1909 10,744 13 121.0 1902 37,776 8 21.2 1910 10,711 9 84.0 1903 1904 38,074 38,372 3 8 7.9 20.8 1906-1910 53,885 10,678 39 15 72.4 140.5 1905 1901-1905 38,670 7 36 18.1 1911 190,371 18.9 1912 10,646 9 84.5 1913 10,614 17 160.2 1906 38,968 6 15.4 1914 10,572 5 47.3 1907 1908 39,266 39,564 7 8 17.8 20.2 Source: Sanitary Reports for St. 1909 39,862 4 10.0 Thomas, D W.I. 1910 1906-19.10 40,160 4 29 10.0 197,820 14.7 1911 40,458 8 19.8 1912 40,814 11 27.0 1913 41,170 5 12.1 Source: Letter from the Acting Regis- trar-General of British Honduras 49 751 APPENDIX G Table 320 Mortality from Cancer in British Guiana 1896-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1896 287,528 60 20.9 1906 299,573 72 24.0 1897 289,368 57 19.7 1907 299,791 55 18.3 1898 291,208 48 16.5 1908 297,997 75 25.2 1899 293,048 49 16.7 1909 297,905 49 16.4 1900 294,888 70 284 23.7 19.5 1910 1906-1910 297,097 38 289 12.8 1896-1900 1,456,040 1,492,363 19.4 1901 296,728 78 26.3 1911 295,879 49 16.6 1902 297,306 54 18.2 1912 299,044 60 20.1 1903 297,884 75 25.2 1913 301,596 88 29.2 1904 297,398 59 19.8 1905 297,416 59 19.8 Source: British Guiana, Report of the Registrar-General . 1901-1905 1,486,732 325 21.9 Table 321 Mortality from Cancer in British Guiana, Males 1896-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1896 153,080 21 13.7 1906 157,554 31 19.7 1897 154,060 30 19.5 1907 157,158 14 8.9 1898 155,039 20 12.9 1908 155,746 33 21.2 1899 156,019 18 11.5 1909 155,380 19 12.2 1900 156,998 20 109 12.7 14.1 1910 1906-1910 154,616 21 118 13.6 1896-1900 775,196 780,454 15.1 1901 157,978 26 16.5 1911 153,602 21 13.7 1902 158,273 21 13.3 1912 155,154 32 20.6 1903 158,041 38 24.0 1913 156,563 31 19.8 1904 157,288 18 11.4 1905 156,846 13 8.3 Source: British Guiana, Report of the Registrar- General. 1901-1905 788,426 116 14.7 752 APPENDIX G Table 322 Mortality from Cancer in British Guiana, Females 1896-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1896 134,448 39 29.0 1906 142,019 41 28.9 1897 135,308 27 20.0 1907 142,633 41 28.7 1898 136,169 28 20.6 1908 142,251 42 29.5 1899 137,029 31 22.6 1909 142,525 30 21.0 1900 137,890 50 175 36.3 25.7 1910 1906-1910 142,481 17 171 11.9 1896-1900 680,844 711,909 24.0 1901 138,750 52 37.5 1911 142,277 28 19.7 1902 139,033 33 23.7 1912 143,890 28 19.5 1903 139,843 37 26.5 1913 145,033 57 39.3 1904 140,110 41 29.3 1905 140,570 46 32.7 Source : British Guiana, Report of the Registrar-General. 1901-1905 698,306 209 29.9 Table 323 Mortality from Cancer in the City of Paramaribo, Dutch Guiana 1903-1912 Year Population Deaths from Cancer Rate per 100,000 Population 1903 33,100 28 84.6 1904 33,535 31 92.4 1905 34,085 30 88.0 1906 34,870 27 77.4 1907 34,962 36 103.0 1908 34,795 54 155.2 1909 35,082 34 96.9 1910 35,000 32 183 91.4 06-1910 174,709 104.7 1911 34,898 28 80.2 1912 35,000 19 54.3 Source: Original data furnished by the Secretary to the Governor of Suriname. 753 APPENDIX G Table 324 Mortality from Cancer in the City of Paramaribo, Dutch Guiana, by Sex 1903-1912 MALES FEMALES Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1903 15,100 9 59.6 1903 18,000 19 105.6 1904 15,392 7 45.5 1904 18,143 24 132.3 1905 15,726 8 50.9 1905 18,359 22 119.8 1906 15,973 10 62.6 1906 18,897 17 90.0 1907 16,168 17 105.1 1907 18,794 19 101.1 1908 16,162 24 148.5 1908 18,633 30 161.0 1909 16,176 11 68.0 1909 18,906 23 121.7 1910 16,200 10 72 61.7 89.2 1910 1906-1910 18,800 22 111 117.0 1906-1910 80,679 94,030 118.0 1911 16,259 12 73.8 1911 18,639 16 85.8 1912 16,300 7 42.9 1912 18,700 12 64.2 Source: Original data furnished by the Secretary to the Governor of Sirriname. Table 325 Mortality from Cancer in Cuba 1901-1913 Year Population Deaths from Cancer Rate per 100,000 Populatioi 1901 1902 1903 1904 1905 1,691,843 1,751,366 1,810,889 1,870,412 1,929,935 503 539 601 661 746 29.7 30.8 33.2 35.3 38.7 1901-1905 9,054,445 3,050 33.7 1906 1907 1908 1909 1910 1,989,458 2,048,980 2,082,691 2,116,402 2,150,112 808 813 901 981 991 40.6 39.7 43.3 46.4 46.1 1906-1910 10,387,643 4,494 43.3 1911 1912 1913 2,229,257 2,313,615 2,391,134 977 1,005 1,145 43.8 43.4 47.9 Source: Informe bi-anual Sanitario y Demografico de la Republica de Cuba, 1902-1905. Sanidad y Beneficencia. Boletin oficial de la Secretaria, 1906-1912. 754 APPENDIX G Table 326 Mortality from Cancer in Cuba, by Sex 1902-1913 MALES FEMALES Deaths Rale per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1902 912,585 245 26.8 1902 838,781 294 35.1 1903 945,045 293 31.0 1903 865,844 308 35.6 1904 977,505 310 31.7 1904 892,907 351 39.3 1905 1,009,965 358 35.4 31.4 1905 1902-1905 919,970 388 42.2 1902-1905 3,845,100 1,206 3,517,502 1,341 38.1 1906 1,042,425 360 34.5 1906 947,033 448 47.3 1907 1,074,882 393 36.6 1907 974,098 420 43.1 1908 1,093,880 453 41.4 1908 988,811 448 45.3 1909 1,112,878 501 45.0 1909 1,003,524 480 47.8 1910 1,131,876 516 45.6 40.7 1910 1906-1910 1,018,236 475 46.6 1906-1910 5,455,941 2,223 4,931,702 2,271 46.0 1911 1,175,041 500 42.6 1911 1,054,216 477 45.2 1912 1,221,126 516 42.3 1912 1,092,489 489 44.8 1913 1,262,041 605 47.9 1913 1,129,093 540 47.8 Source: Informe bi-anual Sanitario v Demografico de la Republica de Cuba, 1902-1905. Sanidad y Beneficencia. Boletin oficial de la Secretaria, 1906-1913. Table 327 Mortality from Cancer in Cuba, by Organs and Parts, according to Sex 1908-1912 MALES Organ or Part Buccal cavity Stomach and liver Peritoneum, intestines, rectum. Female generative organs Breast Skin Other or not specified organs. . Deaths from Cancer 455 870 143 7 140 871 All organs 2,486 Rate per 100,000 Population 7.9 15.2 2.5 o.i 2.4 15.2 43.3 FEMALES Deaths Rate per from 100,000 Cancer Population 138 2.7 513 9.9 160 3.1 973 18.9 232 4.5 75 1.5 278 5.4 2,369 45.9 Source: Sanidad y Beneficencia. Boletin oficial de la Secretaria. Habana. 755 APPENDIX G Table 328 Mortality from Cancer in Cuba, by Organs and Parts, according to Race 1908-1912 WHITE Organ or Part Deaths from Cancer Buccal cavity 485 Stomach and liver 1,014 Peritoneum, intestines, rectum . Breast Female generative organs Skin Other or not specified organs . . 232 148 626 171 956 Rate per 100,000 Population 6.4 13.5 3.1 2.0 8.3 23 12.7 COLORED Deaths Rate per from 100.000 Cancer Population 108 3.4 369 11.5 71 2.2 91 2.8 347 10.8 44 1.4 193 6.0 All organs 3,632 48.2 1,223 38.0 Source: Sanidad y Beneficencia. Boletin oficial de la Secretaria. Habana. Table 329 Mortality from Cancer in Havana, Cuba 1899-1912 Deaths Rate per Year Population from 100,000 Cancer Population 1899 242,055 142 58.7 1900 249,613 140 56.1 1901 257,172 171 66.5 1902 264,731 176 66.5 1903 272,290 213 78.2 1904 279,849 210 75.0 1905 287,408 232 80.7 01-1905 1,361,450 1,002 73.6 1906 294,967 268 90.9 1907 302,526 269 88.9 1908 310,616 318 102.4 1909 318,706 344 107.9 1910 326,796 338 103.4 06-1910 1,553,611 1,537 98.9 1911 334,886 340 101.5 1912 353,509 329 93.1 Source: Informe bi-anual Sanitario y Demografico de la RepubHca de Cuba, 1902-1905. Sanidad y Beneficencia. Boletin oficial de la Secretaria, 1906-1912. 756 APPENDIX G Table 330 Mortality from Cancer in Porto Rico 1910-1913 ■y Deaths Rate per (Endfilg Population from 100,000 June 30) Cancer Population 1910 1,113,406 207 18.6 1911 1,129,198 195 17.3 1912 1,144,990 223 19.5 1913 1,160,782 285 24.6 1910-1913 4,548,376 910 20.0 Source: Informe Anual del Director de Sanidad al Hon. Gobernador de Puerto Rico. Table 331 Mortality from Cancer in Porto Rico, by Organs and Parts July 1, 1910, to June 30, 1913 Deaths Rate per Organ or Part from 100,000 Cancer Population Buccal cavity 37 1.1 Stomach and liver 174 5.1 Peritoneum, intestines and rectum 56 1.6 Generative organs 229 6.7 Breast 20 0.6 Skin : 25 0.7 Other or not specified organs 162 4.7 All organs 703 20.5 Source: Informe Anual del Director de Sanidad al Hon. Gobernador de Puerto Rico. 757 APPENDIX G Table 332 Mortality from Cancer in the City of Mexico, by Sex 1905-1913 TOTAL 3MALES Year 1905 Population 419,981 Deaths from Cancer 249 Rate per 100,000 Population 59.3 Year 1905 Population 196,209 Deaths from Cancer 61 Rate per 100,000 Population 31.1 1906 1907 1908 1909 1910 430,198 440,415 450,632 460,849 471,066 251 243 252 221 229 58.3 55.2 55.9 48.0 48.6 53.1 1906 1907 1908 1909 1910 1906-1910 200,722 205,235 209,748 214,261 218,774 61 77 77 61 51 30.4 37.5 36.7 28.5 23.3 1906-1910 2,253,160 1,196 1,048,740 327 31.2 1911 1912 1913 481,283 491,500 501,717 208 255 242 43.2 51.9 48.2 1911 1912 1913 223,287 227,800 232,313 49 61 55 21.9 26.8 23.7 FEMALES Year 1905 Population 223,772 Deaths from Cancer 188 Rate per 100,000 Population 84.0 1906 1907 1908 1909 1910 229,476 235,180 240,884 246,588 252,292 190 166 175 160 178 82.8 70.6 72.6 64.9 70.6 1906-1910 1.204,420 869 72.2 1911 1912 1913 257,996 263,700 269,404 159 194 187 61.6 73.6 69.4 Source: Boletin del Consejo Superior de Salubridad. Publicacion Mensual. Mexico, 1905-1913. 758 APPENDIX G Table 333 Mortality from Cancer in the City of Mexico, by Organs and Parts according to Sex, 1908-1912 Organ or Part Buccal cavity Stomach and liver Peritoneum, intestines, rectum . Female generative organs Breast Skin Other or not specified organs . . Deaths from Cancer 30 80 26 20 143 299 MALES Rate per 100,000 Population 2.7 7.3 2.4 1.8 13.1 27.3 FEMALES Deaths Rate per from 100,000 Cancer Population 17 1.3 119 9.4 50 4.0 458 36.3 44 3.5 10 0.8 1G8 13.3 866 68.6 All organs Source: Boletin del Consejo Superior de Salubridad. Publicacion Mensual. Mex- ico, 1908-1912. Table 334 Table 335 Mortality from Cancer in the Re- Mortality from Cancer in Nicaragua public of Costa Rica 1908-1911 1901-1912 M.7\Jt. i.7 i.*i Deaths Population from Rate per 100,000 Deaths Rate per Year Year Population from 100,000 Cancer Population Cancer Population 1908 530,000 80 15.1 1901 307,499 68 22.1 1909 540,000 62 11.5 1902 312,819 84 26.9 1910 550,000 42 7.6 1903 316,738 102 32.2 1911 560,000 47 8.4 1904 322,618 111 34.4 1905 331,340 119 35.9 30.4 1908-1911 Source: 2,180,000 231 Boletin de Estadis 10.6 1901-1905 1,591,014 484 tica de la RepubHca de Nicaragua. 1906 334,297 122 36.5 1907 341,590 133 38.9 1908 351,176 154 43.9 1909 361,779 142 39.3 1910 368,780 140 38.0 39.3 1906-1910 1,757,622 691 1911 379,533 144 37.9 1912 388,266 171 44.0 Source: Resumenes Estadisticos. Anos 1883-1910, San Jose, 1912. Republica de Costa Rica Anuario Esta- distico, 1911-1912. 759 APPENDIX G Table 336 Mortality from Cancer in the City of San Salvador, by Organs and Parts 1912 Deaths Organ or Part from Cancer Tongue 1 Throat 3 Stomach 11 Uterus 1 Not specified 17 Sarcoma 1 All organs 34 Source: Memoria de la Municipalidad de San Salvador, 1912. Rate per 100,000 Population 1.7 5.0 18.5 1.7 28.6 1.7 57.1 Table 337 Mortality from Cancer in the Re- public of Venezuela, 1905-1912 Year Population 1905 2,608,033 Deaths Rate per from 100,000 Cancer Population 407 15.6 1906 1907 1908 1909 1910 2,627,434 2,646,835 2,666,236 2,685,637 2,705,038 429 396 386 346 403 1906-1910 13,331,180 1.960 1911 1912 Source: zuela. 2,724,439 2,743,841 437 430 16.3 15.0 14.5 12.9 14.9 14.7 16.0 15.7 Anuario Estadistico de Vene- Table 338 Mortality from Cancer in the City of Bogota, Colombia, 1912-1913 Year 1912 1913 Population 121,257 121,729 Deaths Rate per from 100,000 Cancer Population 112 92.4 106 87.1 1912-1913 242,986 218 89.7 Source: Registro Municipal de Higiene, Table 339 Mortality from Cancer in Guayaquil Ecuador, 1910-1912 Year Population 1910* 1911 1912 40,000 80,000 80,000 Deaths Rate per from 100,000 Cancer Population 23 57.5 57 71.3 42 52.5 1910-1912 200,000 122 61.0 Source: Original data furnished by Mr. Charles S. Hartman, envoy extraordinary and minister plenipotentiary, Quito, Ecua- dor. *January to June. Table 340 Mortality from Cancer in the City of La Paz, Bolivia, 1900-1909 Deaths Rate per Year Population from 100,000 Cancer Population 1900 59,633 i 3.4 1901 59,832 13 21.7 1902 60,031 18 30.0 1903 62,720 12 19.1 1904 65,409 10 15.3 1905 68,098 16 69 23.5 1901-1905 316,090 21.8 1906 70,787 18 25.4 1907 73,476 2 2.7 1908 76,166 6 7.9 1909 78.856 4 5.1 Source: Censo Municipal de la Ciudad de La Paz 15 de Junio de 1909. 760 APPENDIX G Table 341 Mortality from Cancer in the City of Lima, Peru, by Organs and Parts according to Sex, 1904 Deaths Rate per from 100,000 Cancer Population 4 3.1 53 40.8 9 6.9 35 26.9 2 1.5 1 . 0.8 31 23.8 Organ or Part Buccal cavity Stomach and liver Peritoneum, intestines, rectum. Female generative organs Breast Skin Other or not specified organs. . All organs 135 103.8 50 85 Source: Datos Demograficos de la Ciudad de Lima en el Ano de 1904. Deaths fbo&i Canceb Males Females 2 2 27 26 2 7 35 2 1 18 13 Table 342 Mortality from Cancer in the City of Trujillo 1903-1913 Year Population Deaths from Cancer Rate per 100,000 Population 1903 8,000 6 75.0 1904 8,000 8 100.0 1905 8,000 9 23 112.5 1903-1905 24,000 95.8 1906 8,000 7 87.5 1907 8,000 13 62.5 1908 8,000 16 200.0 1909 8,000 9 112.5 1910 8,000 12 67 150.0 1906-1910 40,000 142.5 1911 8,000 18 225.0 1912 8,000 14 175.0 1913 8,000 14 175.0 Source: Original data furnished by the Director of Registro Civil y Estadistica, Trujillo, Peru. 761 APPENDIX G Table 343 Mortality from Cancer in the City of Rio de Janeiro, Brazil 1891-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 440,118 151 34.3 1906 625,756 291 46.5 1892 450,636 153 34.0 1907 636,018 271 42.6 1893 461,411 149 32.3 1908 637,089 290 45.5 1894 472,454 152 32.2 1909 649,362 285 43.9 1895 483,773 164 33.9 33.3 1910 1906-1910 669,781 295 44.0 1891-1895 2,308,392 769 3,218,006 1,432 44.5 1896 405,380 167 33.7 1911 690,200 282 40.9 1897 507,286 168 33.1 1912 710,600 275 38.7 1898 519,503 189 36.4 1913 731,000 304 41.6 1899 532,042 179 33.6 1900 544,917 199 36.5 Source: Annuario Estatistico Demo- rr^ 1 Cr.Tii4-n-»,^n "O i ^ A^ T n n ^i 1896-1900 2,599,128 902 34.7 ffr£ipiio-o3.r "'^ IXUaXlCky A.\jl\J VJ ns uaL±s:^XL\j 1901 558,140 189 33.9 1902 571,728 197 34.5 1903 585,695 235 40.1 1904 600,057 240 40.0 1905 614,831 237 38.5 37.5 1901-1905 2,930,451 1,098 Table 344 Mortality from Cancer in the Federal District of Rio de Janeiro 1903-1913 Year Population Deaths from Cancer Rate per 100,000 Population 1903 1904 1905 749,180 771,276 794,266 254 260 257 33.9 33.7 32.4 1906 1907 1908 1909 1910 811,443 824,040 825,812 842,822 870,475 318 293 313 306 334 39.2 35.6 37.9 36.3 38.4 06-1910 4,174,592 1,564 37.5 1911 1912 1913 912,169 965,766 980,094 328 312 356 36.0 32.3 36.3 Source: Annuario Estatistico Demo- grapho-Sanitaria, Rio de Janeiro. 762 APPENDIX G Table 345 Mortality from Cancer in the Federal District of Rio de Janeiro by Organs and Parts, Males, 1906-1910 Organ or Part 1906 1907 1908 1909 1910 1908-10 Buccal cavity 29 13 17 20 14 93 Stomach 34 36 42 37 36 185 Liver 6 6 17 13 11 63 Peritoneum, intestines, rectum . . 6 5 11 9 10 41 Skin 9 16 9 9 5 48 Other or not specified organs ... 50 69 66 65 75 325 All organs 134 145 162 153 15 745 Source: Annuario Estatistico Demographo-Sanitaria, Rio de Janeiro. Per Cent, of All Organs 12.5 24.8 7.1 5.5 6.5 43.6 100.0 Table 346 Mortality from Cancer in the Federal District of Rio de Janeiro by Organs and Parts, Females, 1906-1910 Organ or Part 1906 1907 1908 1909 1910 Buccal cavity 6 4 2 2 7 Stomach 12 9 11 9 12 Liver 6 1 4 4 4 Peritoneuna, intestines, rectum . . 5 8 5 5 9 Breast 13 11 9 15 16 Generative organs 66 50 58 52 50 Skin 4 2 7 3 1 Other organs 72 63 55 63 84 All organs 184 148 151 153 183 Source: Annuario Estatistico Demographo-Sanitaria, Rio de Janeiro. Per Cent. 906-10 of All Organs 21 2.6 53 6.5 19 2.3 32 3.9 64 7.8 276 33.7 17 2.1 337 41.1 819 100.0 763 APPENDIX G Table 347 Mortality from Cancer in the City of Bahia 1897-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1897 196,394 32 16.3 1906 251,500 59 23.5 1898 199,534 24 12.0 1907 259,200 54 20.8 1899 202,673 38 18.7 1908 266,900 72 27.0 1900 205,813 32 15.5 1909 274,600 71 25.9 1910 282,300 68 20.5 1897-1900 804,414 126 15.7 1906-1910 1,334,500 314 23.5 1901 213,400 47 22.0 1902 221,000 58 26.2 1911 290,000 68 23.4 1903 228,600 72 31.5 1912 300,000 59 19.7 1904 236,200 69 29.2 1905 243,800 53 21.7 Source: Annuario de Estatistica Demo- grapho-Sanitaria da Cidade do Salvador 1901-1905 1,143.000 299 26.2 (Bahia), 1900-1908. Boletin Mensal de Estatistica Demo- grapho-Sanitaria da Cidade do Salvador, 1909-1912. Table 348 Mortality from Cancer in the City of Bahia, Males 1900-1911 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1900 97,642 6 6.1 1906 119,300 13 10.9 1907 123,000 15 12.2 1901 101,200 12 11.9 1908 126,700 19 15.0 1902 104,800 13- 12.4 1909 130,400 22 16.9 1903 108,400 18 16.6 1910 134,100 21 15.7 1904 112,000 21 18.8 1905 115,600 17 81 14.7 14.9 1906-1910 1911 633,500 137,800 90 21 14.2 1901-1905 542,000 15.2 Source: Annuario de Estatistica Demo- grapho-Sanitaria da Cidade do Salvador (Bahia), 1900-1908. Boletin Mensal de Estatistica Demo- grapho-Sanitaria da Cidade do Salvador, 1909-1911. 764 APPENDIX G Table 349 Mortality from Cancer in the City of Bahia, Females 1900-1911 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1900 108.171 26 24.0 1906 132,200 46 34.8 1907 136,200 39 28.6 1901 112.200 35 31.2 1908 140,200 53 37.8 1902 116,200 45 38.7 1909 144,200 49 34.0 1903 120,200 54 44.9 1910 148,200 37 25.0 1904 124,200 48 38.6 1905 128,200 36 218 28.1 36.3 1906-1910 1911 701,000 152,200 224 47 32.0 1901-1905 601,000 30.9 Source: Annuario de Estatistica Demo- grapho-Sanitaria da Cidade do Salvador (Bahia), 1900-1908. Boletin Mensal de Estatistica Demo- grapho-Sanitaria da Cidade do Salvador, 1909-1911. Table 350 Mortality from Cancer in the City of Bahia, by Organs and Parts according to Sex, 1904-1908 MALES Organ or Part Buccal cavity Stomach Liver Peritoneum, intestines, rectum . Femal© generative organs Breast Skin Other or not specified organs All organs Deaths from Cancer Rate per 100,000 Population 15 13 6 9 2.5 2.2 1.0 1.5 8 34 1.3 5.7 85 14.2 FEMALES Deaths Rate per from 100,000 Cancer Population 3 0.5 9 1.4 9 1.4 10 1.5 94 14.2 20 3.0 6 0.9 71 10.7 33.6 Source: Annuario de Estatistica Demographo-Sanitaria da Cidade do Salvador (Bahia) . 765 APPENDIX G Table 351 Mortality from Cancer in the City of Sao Paulo 1896-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1896 169,864 61 35.9 1906 288,000 80 27.8 1897 187,353 51 27.2 1907 296,000 128 43.2 1898 204,842 57 27.8 1908 304,000 143 47.0 1899 222,331 48 21.6 1909 312,000 117 37.5 1900 239,820 52 269 21.7 26.3 1910 1906-1910 320,000 153 621 47.8 1896-1900 1,024,210 1,520,000 40.9 1901 248,000 66 26.6 1911 358,000 156 43.6 1902 256,000 68 26.6 1912 400,000 200 50.0 1903 264,000 84 31.8 1913 450,000 201 44.7 1904 272,000 100 36.8 1905 280,000 89 31.8 Source: Estado de Sao Paulo. Direc- toria do Servigo S Demographico, 1901-1 Annuario 1901-1905 1,320.000 407 30.8 912. Table 352 Mortality from Cancer in the City of Sao Paulo, Males 1901-1913 Year Population Deaths Rate per 1901 1902 1903 1904 1905 129,000 133,000 137,000 141,000 146,000 1901-1905 686,000 1906 1907 1908 1909 1910 150,000 155,000 160,000 164,000 168,000 1906-1910 797,000 1911 1912 1913 188,000 210,000 235,000 from Cancer 26 32 42 55 42 197 36 72 72 59 77 316 84 102 107 100,000 Population 20.2 24.1 30.7 39.0 28.8 28.7 24.0 46.5 45.0 36.0 45.8 39.6 44.7 48.6 45.5 Source: Estado de Sao Paulo. Direc- toria do Servigo Sanitario. Annuario Demographico, 1901-1912. Table 353 Mortality from Cancer in the City of Sao Paulo, Females 1901-1913 Year 1901 1902 1903 1904 1905 Population 119,000 123,000 127,000 131,000 134,000 1901-1905 634,000 1906 1907 1908 1909 1910 138,000 141,000 144,000 148,000 152,000 1906-1910 723,000 1911 1912 1913 170,000 190,000 215,000 Deaths from Cancer 40 36 42 45 47 210 44 56 71 58 76 305 72 98 94 Rate per 100,000 Population 33.6 29.3 33.1 34.4 35.1 33.1 31.9 39.7 49.3 39.2 50.0 42.2 42.4 51.6 43.7 Soiu"ce: Estado de Sao Paulo. Direc- toria do Ser\dQO Sanitario. Annuario Demographico, 1901-1912. 766 APPENDIX G Table 354 Table 357 Mortality from Cancer i n the Mortality from Cancer in th e Prov- State of Parana ince of Buenos Aires, Argentina 1906- 1910 Rate per 1895-19 12 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1906 351,341 37 10.5 1895 910,664 370 40.6 1907 355,761. 32 9.0 1908 368,985 45 12.2 1896 955,258 438 45.9 1909 380,000 38 10.0 1897 1,025,012 496 48.4 1910 400,000 40 10.0 1898 1,074,119 511 47.6 1899 1,122,549 1,177,381 525 46.8 1906-1910 1,856,087 Relatorie 192 10.3 pelo el Director de 1900 1896-1900 627 53.3 Source: 5,354,319 2,597 48.5 Service Sanitario do Parana; accempan- hado da Estatistica Demographo -Sanitaria. 1901 1,231,453 021 50.4 1902 1,269,452 056 51.7 Table 355 1903 1904 1,295,810 1,331,959 715 759 55.2 57.0 Mortality from Cancer in the 1905 1,379,191 882 64.0 City of ] 1906- *elotas 1913 Rate per 100,000 Population 1901-1905 1906 1907 6,507,865 1,462,287 1,527,897 3,633 896 921 55.8 Year Population Deaths from Cancer 61.3 60.3 1906 32,308 27 83.6 1908 1,600,465 994 62.1 1907 33,290 38 114.1 1909 1,684,642 1,053 62.5 1908 34,272 35,254 29 37 84.6 105.0 1910 1,865,192 1,084 58.1 1909 1910 36,243 26 157 71.7 91.6 1906-1910 1911 8,140,483 1,950,785 4,948 1,015 60.8 1906-1910 171,367 52.0 1912 2,069,610 1,100 53.2 1911 1912 37,225 38,207 28 27 75.2 70.7 Source: Direccion General de Estadis- 1913 39,189 25 63.8 tica de la Provincia de Buenos Aires: Memoria Demographics , 1895. Source: Municipio de Pelotas. Re- Anuario Estadistico, 1896-1897. latorio apresentado ao Censelhe Municipal, Demographia, 1898-1905. 1906-1913. Boletin Mensual de la Direccion de Estadistica , 1906-1912. Table 356 Mortality from Cancer in the City of Belle Horizonte 1910- 1912 Rate per Deaths Year Population from Cancer 100,000 Population 1910 35,000 8 22.9 1911 37,435 17 45.4 1912 39,845 16 41 40.2 36.5 1910-1912 112,280 Source: Annuario de Estatis tica Deme- grapho-Sanitaria de Belle Horizente. 767 APPENDIX G . Table 358 Mortality from Cancer in the Province of Buenos Aires, Males 1895-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1895 512,431 209 40.8 1906 823,268 543 66.0 1907 860,206 554 64.4 1896 537,524 247 46.0 1908 901,061 588 65.3 1897 576,774 279 48.4 1999 950,138 653 68.7 1898 1899 604,407 631,658 305 286 50.5 45.3 1910 1,051,968 634 60.3 1900 662,865 397 59.9 50.2 1906-1910 1911 4,586,641 1,100,243 2,972 589 64.8 1896-1900 3,013,228 1,514 53.5 1912 1,167,260 647 55.4 1901 693,308 342 49.3 1902 714,701 379 53.0 Source: Direccion General de Estadis- 1903 729,541 426 58.4 tica de la Provincia de Buencs Aires : 1904 749,893 462 61.6 Memoria Demographica, 1895. 1905 776,484 533 68.6 Anuario Estadistico, 1896-1897. DpmnoTai->V.;Q ISOS-IOOt 1901-1905 3,663,927 2,142 58.5 Boletin Mensual de la Direccion de Estadistica , 1906-1912. Table 359 Mortality from Cancer in the Province of Buenos Aires, Females 1895-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1895 398,233 161 40.4 1906 639,019 353 55.2 1907 667,691 367 55.0 1896 417,734 191 45.7 1908 699,404 406 58.0 1897 448,238 217 48.4 1909 734,504 400 54.5 1898 469,712 206 43.9 1910 813,224 450 55.3 1899 490,891 239 48.7 1900 514,516 230 44.7 46.3 1906-1910 1911 3,553,842 850,542 1,976 426 55.6 1896-1900 2,341,091 1,083 50.1 1912 902,350 453 50.2 1901 538,145 279 51.8 1902 554,751 277 49.9 Source: Direccion General de Estadis- 1903 566,269 289 51.0 tica de la Provincia de Buenos Aires : 1904 582,066 297 51.0 Memoria Demographica, 1895. 1905 602,707 349 57.9 Anuario Estadistico, 1896-1897 Demographia, 1898-1905. 1901-1905 2,843,938 1,491 52.4 Boletin Mensual de la Direccion de Estadistica , 1906-1912. 768 APPENDIX G Table 360 Mortality from Cancer in the City of Buenos Aires 1882-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1882 362,373 192 53.0 1901 854,988 723 84.6 1883 376,573 177 47.0 1902 886,986 763 86.0 1884 390,773 170 43.5 1903 918,984 864 94.0 1885 404,973 218 53.8 1904 950,981 890 93.6 1886 419,173 213 50.8 49.6 1905 1901-1905 1,007,124 950 94.3 1882-188G 1,953,865 970 4,619,063 4,190 90.7 1889 490,779 352 71.7 1906 1,063,267 982 92.4 1890 519,482 308 59.3 1907 1,119,410 983 87.8 1908 1,175,553 1,030 87.6 1891 548,185 324 59.1 1909 1,231,698 1,026 83.3 1892 576,888 370 64.1 1910 1,282,353 1,034 80.6 1893 605,591 427 70.5 1894 634,293 442 69.7 1906-1910 5,872,281 5,055 86.1 1895 663,000 461 69.5 1911 1,333,008 1,175 88.1 1891-1895 3,027,957 2,024 66.8 1912 1,383,663 1,210 87.4 1913 1,434,318 1,266 88.3 1896 694,998 514 74.0 1897 726,996 629 86.5 Source: Year-Book of the City of 1898 758,994 554 73.0 Buenos Aires. 1899 790,992 614 77.6 1900 822,990 748 90.9 80.6 k 1896-1900 3,794,970 3,059 Table 361 Mortality from Cancer in the City of Buenos Aires, Males 1896-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1896 372,102 301 80.9 1906 558,640 607 108.7 1897 388,070 359 92.5 1907 589,593 584 99.1 1898 403,937 314 77.7 1908 620,692 632 101.8 1899 419,700 351 83.6 1909 651,938 617 94.6 1900 435,362 439 100.8 87.4 1910 1906-1910 680,416 622 91.4 1896-1900 2,019,171 1,764 3,101,279 3,062 98.7 1901 451,006 441 97.8 1911 708,361 733 103.5 1902 466,555 485 104.0 1912 736,109 720 97.8 1903 482,007 503 104.4 1913 763,660 742 97.2 1904 497,363 548 110.2 1905 527,934 562 106.5 Source : Year-Book of the City of Tiny-i»-»/-.C7 Ai-M/^o 1901-1905 2,424,865 2,539 104.7 769 APPENDIX G Table 362 Mortality from Cancer in the City of Buenos Aires, Females 1896-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1896 322,896 213 66.0 1906 504,627 375 74.3 1897 338,926 270 79.7 1907 529,817 399 75.3 1898 355,057 240 67.6 1908 554,861 398 71.7 1899 371,292 263 70.8 1909 579,760 409 70.5 1900 387,628 309 79.7 72.9 1910 1906-1910 601,937 412 68.4 1896-1900 1,775,799 1,295 2,771,002 1,993 71.9 1901 403,982 282 69.8 1911 624,647 442 70.8 1902 420,431 278 66.1 1912 647,554 490 75.7 1903 436,977 361 82.6 1913 670,658 524 78.1 1904 453,618 342 75.4 1905 479,190 388 81.0 Source : Year-Book of the City of 1901-1905 2,194,198 1,651 75.2 Table 363 Mortality from Cancer in the City of Buenos Aires, by Organs and Parts according to Sex, 1907-1911 MALES • Deaths Rate per Organ or Part from 100,000 Cancer Population Buccal cavity 210 6.46 Stomach and liver 1,740 53.52 Peritoneum, intestines, rectum . . 147 4.52 Female generative organs Breast Skin 66 2.03 Other or not specified organs 1,025 31.53 All organs 3,188 98.06 Source : Year-Book of the City of Buenos Aires. FEMALES Deaths Rate per from 100,000 Cancer Population 33 1.14 677 23.42 131 4.53 532 18.40 137 4.74 24 0.83 526 18.19 2,060 71.25 770 APPENDIX G Table 364 Table 366 Mortality from Cancer in the City of Mortality from Cancer in th e City of Rosario de Santa Fe Rosario de Santa Fe, Females 1904- 1913 Rate per 1904-1911 Deaths Deaths Rate per Year Population from 100,000 Year Population from 100,000 Caacer Population Cancer Population 1904 128,078 83 64.8 1904 59,479 38 63.9 1905 130,565 91 69.7 1905 60,595 41 67.7 1906 141,127 123 87.2 1906 65,455 47 71.8 1907 151,887 91 59.9 1907 70,400 39 55.4 1908 160,225 112 69.9 1908 74,216 50 67.4 1909 171,796 121 70.4 1909 79,507 51 64.1 1910 187,428 156 603 83.2 74.2 1910 1906-1910 86,667 72 259 83.1 1906-1910 812,463 376,245 68.8 1911 203,886 145 71.1 1911 94,195 57 60.5 1912 214,269 150 70.0 1913 225,600 138 61.2 Source: Anuario Estadistico de la Ciudad del Rosario de Santa Fe. Source : Anuario Estadisticc Rosario de Santa Fe. ) de la Ciudad del Boletin Mensual de Estadistica Munici- Table 367 pal de la Ciudad del Rosario de Santa Fe. Mortality from Cancer in the Prov- ince of Tucuman 1901-1912 Table 365 from Cancer in the Cityof Mortality Deaths Rate per Rosario de Santa Fe, Males Year Population from 100,000 1904-] 1911 Cancer Population Rate per 1901 1902 252,098 254,762 46 44 18.2 Deaths 17.3 Year Population from 100,000 1903 257,427 47 18.3 Cancer 'opulation 1904 263,079 40 15.2 1904 68,599 45 65.6 1905 269,617 39 14.4 1905 69,970 50 71.5 1901-1905 1,296,983 216 16.7 1906 75,672 76 100.4 1907 81,487 52 63.8 1906 291,230 39 13.4 1908 86,009 62 72.1 1907 299,241 36 12.0 1909 92,289 70 75.8 1908 311,600 48 15.4 1910 100,761 84 83.4 1909 312,519 55 17.6 1910 320,933 57 17.8 1906-1910 436,218 344 79.0 1906-1910 1,535,523 235 15.3 1911 109,691 88 80.2 1911 325,209 62 19.1 Source : Anuario Estadisticc de la 1912 329,485 75 22.8 Ciudad del Rosario de Santa Fe. Source : Anuario de Estadistica de la Provincia de Tucuman correspondiente al Ano de 1910. 771 APPENDIX G Table 368 Mortality from Cancer in the City of Santiago del Estero 1891-1913 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1891 11,805 2 16.9 1906 16,578 4 24.1 1892 12,036 3 24.9 1907 17,170 16 93.2 1893 12,272 5 40.7 1908 17,852 11 61.6 1894 12,512 6 48.0 1909 18,534 3 16.2 1895 12,892 6 22 46.5 35.8 1910 1906-1910 19,216 8 42 41.6 1891-1895 61.517 89,350 47.0 1896 13,324 12 90.1 1911 19,898 3 15.1 1897 13,657 9 65.9 1912 20,580 11 53.4 1898 13,989 6 42.9 1913 21,262 8 37.6 1899 14,290 2 14.0 1900 14,698 1 6.8 Source: Direccion General de Estadis- 1896-1900 69,958 30 42.9 Santiago del Estero. Mortalidad General, 1890-1908. 1901 15,066 7 46.5 1909-1913 by correspondence with Di- 1902 15,339 6 39.1 reccion General de Estadistica j ' Registro 1903 15,556 Civil, Santiago del Estero. 1904 15,827 6 31.6 1905. 16,168 7 25 43.3 32.1 1901-1905 77,956 Table 369 Mortality from Cancer in the Republic of Chile 1892-1912 Deaths Rate per Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1892 2,645,408 457 17.3 1906 3,202,510 1,209 37.8 1893 2,664,190 455 17.1 1907 3,249,279 1,251 38.5 1894 2,683,105 546 20.3 1908 3,297,585 1,434 43.5 1895 2,712,145 426 15.7 1909 3,347,124 1,369 40.9 1896 2,753,369 554 20.1 18.1 1910 1906-1910 3,415,060 1,089 31.9 1892-1896 13,458,217 2,438 16.511,558 6,352 38.5 1903 3,060,807 894 29.2 1911 3,483,000 1,031 29.6 1904 3,107,331 1,194 38.4 1912 3,505,017 1,154 32.9 1905 3,154,561 954 30.2 Source: publica d PnV.lar>TnTl On\mt\nAn Aa lo TJo- 1903-1905 9,322,699 3,042 32.6 5 Chile en 1910 i Resena del Movimiento de Poblacion del mismo ano. Santiago del Chile, 1912. * Report of the Regist rar-General for Eng- land and Wales, 1912. 772 APPENDIX G Table 370 Table 371 Mortality from Cancer in the Prov- Mortality from Cancer in th le City ince of Santiago de Chile of Santiago de Chile 1904-19 12 Deaths Rate per 1898-1909 Deaths Rate per Year Population from 100,000 Year Population from 100,000 Cancer Population Cancer Population 1904 487,021 266 54.6 1898 270,704 250 92.4 1905 496,904 321 64.6 1899 275,638 272 98.7 1900 281,886 296 105.0 1906 506,887 406 80.1 1901 288,645 222 76.9 1907 616,870 301 58.2 1902 295,059 230 78.0 1908 526,853 536,836 301 399 57.1 74.3 1909 1898-1902 1,411,932 1,270 89.9 1910 546,819 373 68.2 1903 302,538 251 83.0 1906-1910 2,634,265 1,780 67.6 1904 309,510 223 72.0 1905 317,420 233 73.4 1911 556,803 270 48.5 1906 324,057 204 63.0 1912 566,787 328 57.9 Correspondence from Direc- 1907 1903-1907 332,724 218 65.5 Source: 1,586,249 1,129 71.2 cioQ General de Estadistica de Chile. 1908 340,210 234 68.8 1909 347,864 293 84.2 Source: Correspond ence from Direc- cion General de Estadistica de Chile. Table 372 Mortality from Cancer in the City of Santiago de Chile, by Organs and Parts 1898-1902 Organ or Part No. of Deaths Per Cent. Head 2 0.26 Face 10 1.31 Lips 1 0.13 Mouth and tongue 17 2.22 Jaw 2 0.26 Larynx and throat 12 1.57 Spine 2 0.26 Lungs 6 0.78 CEsophagus 7 0.91 Stomach 367 47.91 Rectum 20 2.61 Other intestines 40 5.22 Liver 117 15.29 Kidney, spleen and pancreas 8 1.04 Bladder 14 1.83 Uterus and ovaries 89 11.62 Breast 9 1.17 Not specified 43 5.61 All organs 766 100.00 Source: Zeltschrift f iir Krebsforschung. 3. Band. Note: Includes carcinoma only. 773 APPENDIX G Table 373 Mortality from Cancer in the Republic of Uruguay 1891-1913 Year Population Deaths from Cancer Rate per 100,000 Population Year Population Deaths from Cancer Rate per 100,000 Population 1891 708,168 277 39.1 1901 931,527 495 53.1 1892 728,447 335 46.0 1902 947,407 481 50.8 1893 748,130 346 46.2 1903 963,287 501 52.0 1894 776,314 340 43.8 1904 979,166 531 54.2 1895 792,800 350 44.1 43.9 1905 1901-1905 995,046 587 59.0 1891-1895 3,753,859 1,648 4,816,433 2,595 53.9 1896 818,843 411 50.2 1906 1,010,926 667 66.0 1897 827,485 401 48.5 1907 1,026,806 695 67.7 1898 840,725 481 57.2 1908 1,042,686 662 63.5 1899 878,186 468 53.3 1909 1,080,070 704 65.2 1900 915,647 423 46.2 51.0 1910 1906-1910 1,117,454 757 67.7 1896-1900 4,280,886 2,184 5,277,942 3,485 66.0 1911 1,154,838 732 63.4 1912 1,192,222 838 70.3 1913 1,229,606 903 73.4 Source: Anuario Estadistico de la Re- publica Oriental del Uruguay. Table 374 Table 375 Mortality from Cancer in the Repub- lic of Uruguay, Males Mortality from Cancer in the Repub- lic of Uruguay, Females 1905-1912 Rate per 100,000 Population Year 1905-19 12 Deaths from Cancer Year Population Deaths from Cancer Population Rate per 100,000 Population 1905 506,279 340 67.2 1905 488,767 247 50.5 1906 514,359 375 72.9 1906 496,567 292 58.8 1907 522,439 395 75.6 1907 504,367 300 59.5 1908 530,519 389 73.3 1908 512,167 273 53.3 1909 549,540 396 72.1 1909 530,530 308 58.1 1910 568,561 429 75.5 73.9 1910 1906-1910 548,893 355 64.7 1906-1910 2,685,418 1,984 2,592,524 1,528 58.9 1911 587,582 431 73.4 1911 567,256 301 53.1 1912 606,603 477 78.6 1912 585,619 361 61.6 Source : Anuario Estadistico de la Re- Source: Anuario Estadistico de la Re- publica Oriental del Uruguay. publica Oriental del Uruguay. W4 APPENDIX G Table 376 Mortality from Cancer in the Republic of Uruguay, by Organs and Parts according to Sex. Rate per 100,000 of Population 1906-1910 Organ or Part Persons Males Females Buccal cavity 2.0 3.6 0.4 Stomach and liver 35.6 44.4 26.5 Peritoneum, intestines and rectum 4.6 4.2 4.9 Female generative organs , 6.0 . . 12.2 Breast 1.8 . . 3.7 Skin 1.1 1.6 0.5 Other or not specified organs 14.9 19.4 10.4 All organs 66.0 73.2 58.6 Source: Anuario Estadistico de la Republica Oriental del Uruguay. Table 377 Mortality from Cancer in the City of Montevideo 1903-1913 Year Population Deaths from Cancer Rate per 100,000 Population 1903 1904 1905 282,689 289,018 298,533 295 260 320 104.4 90.0 107.2 1906 1907 1908 1909 1910 307,482 309,904 313,016 321,224 329,888 347 385 364 403 406 112.9 124.2 116.3 125.5 123.1 1906-1910 1,581,514 1,905 120.5 1911 1912 1913 338,353 355,017 370,000 364 400 450 107.6 126.7 121.6 Source: Resumen Anual de Estadistica Municipal, Montevideo. Table 378 Mortality from Cancer in the City of Montevideo, by Organs and Parts 1907-1911 Deaths Rate per Organ or Part from 100,000 Cancer Population Buccal cavity 57 3.5 Stomach and liver 1,030 63.9 Peritoneum, intestines and rectum 128 7.9 Female generative organs 172 10.7 Breast 53 3.3 Skin 20 1.2 Other or not specified organs 462 28.7 All organs 1,922 119.2 Source: Resimien Anual de Estadistica Municipal, Montevideo. 775 APPENDIX H Recommendations and Instructions ON THE Control of Cancer Table Page 1 Recommendations to The American Gynecological Society for the National Control of Cancer, by Frederick L. Hoffman 777 2 Purpose and Methods of Work of The American Society for the Control of Cancer 779 3 Instructions on Prevention of Cancer Issued by the Borough of Portsmouth, England 781 i Report on the Prevention of Cancer of the Medical. Officer of Health of the Borough of Shelf, England 783 776 APPENDIX H Table 1 Recommendations to The American Gynecological Society, May 7, 1913, for the National Control of Cancer, by Frederick L. Hoffman RECOMMENDATIONS 1. The organization of an American society* for the study and pre- vention of cancer, primarily for the purpose of educating the pubUc at large in the absolute necessity of operative treatment at the earliest indications of cancerous growths. 2. A thorough investigation into the geographical distribution of cancer throughout the western hemisphere, but with special reference to localities and sections which persistently show a very high or a very low rate of cancer mortality. 3. A thoroughly qualified medical and statistical investigation into the cancer experience data of general and cancer hospitals for a period of sufficient length to determine the precise results of medical and surgi- cal treatment, with a due regard to the after-lifetime, possible recur- rence, or subsequent death of patients discharged as cured or materially improved. 4. A nation-wide agitation for a material improvement and required completeness of the official returns of deaths from cancer, with a due regard to the organs or parts affected, for the purpose of reducing the number and proportion of unclassified or ill-defined cancers to the lowest possible minimum. 5. The Division of Vital Statistics of the Census, as well as all state and municipal boards of health in charge of the registration, tabulation, and analysis of vital statistics should be urged to redistribute the deaths occurring in institutions, according to the permanent or regular resi- dence of the deceased. Only by means of such a correction can the true local incidence of cancer be established, as has been shown with admirable clearness by the investigations of Green, of Edinburgh. 6. A thoroughly scientific investigation, through the cooperation of the Census Office, the Bureau of Labor, the Bureau of Mines, life insurance companies, etc., should be made into the occupational inci- dence of cancer, with regard to which there are strong reasons for believing that a wealth of useful information can be brought to light which is at present unavailable. 7. Since an erroneous diet is a probable causative factor in cancer occurrence, the nutrition of cancerous patients should be investigated in conformity to the strictly scientific and conclusive methods of Pro- fessors Atwater and Chittenden. *"The American Society for the Control of Cancer" was formed in the city of New York on May 22, 1913. 777 APPENDIX H Table 1 (concluded) Recommendations to The American Gynecological Society, May 7, 1913, for the National Control of Cancer, by Frederick L. Hoffman 8. As an aid in the scientific study of cancer, and as a possible means of bringing about a more intelligent public understanding of the accepted facts of cancer occurrence, its nature and probable cure, the disease should be made reportable to the local Board of Health in the same manner as other diseases which are a recognized menace to public health and welfare. 9. As a further aid, the Department of Agriculture should be re- quested to make a thorough study of the occurrence of cancer among domestic animals and plants known, or suspected, to be subject thereto, and such an investigation should, as far as practicable, be coordinated to the work of the Bureau of Soils. 10. The immediate preparation and widest possible distribution of a concise outline of accepted cancer facts, showing the disease in all eases to be of local origin, that the chief danger to the patient Kes in the tendency toward a rapid extension of cancerous growths, that the only certain remedy known to science i's the complete surgical removal of the affected parts at the earliest possible indication of the disease, and that when this is done the outlook for a cure in the accepted sense of the term is decidedly hopeful, but that to the contrary delay and neglect, or refusal to submit to operative treatment, are practically certain to result fatally within a comparatively short period of time. 778 APPENDIX H Table 2 Purpose and Methods of Work of The AmericarL Society for the Control of Cancer The American Society for the Control of Cancer PURPOSE "To disseminate knowledge concerning the symptoms, diagnosis, treatment and prevention of cancer, to investigate the conditions under which cancer is found and to compile statistics in regard thereto." ITS PROBLEM Cancer is one of the chief causes of death. It claims about 75,000 lives every year in the United States. At ages over forty the disease causes one death in eight among women, and one death in fourteen among men. It is preeminently a disease of adult life, and at ages over forty is a greater menace than tuberculosis or pneumonia. Its insidious onset often occurs at the most useful period of life, when the father and mother are of the greatest service to society. ITS OPPORTUNITY Much is known about cancer, but the present knowledge is not suf- ficiently utilized. Cancer is not a constitutional or blood disease, but is at first a local growth, which can at that time be easily removed by prompt surgical operation. This is the only known cure, and the chief hope of controlling the disease lies in a careful campaign of public education in regard to the many well-known conditions under which cancer develops, the first signs, and the vital importance of its early recognition and prompt removal. ITS ORGANIZATION AND AIMS The American Society for the Control of Cancer was established by a group of prominent men and women who were deeply impressed by these facts and saw the need of a national agency to conduct statistical investigations, organize local campaigns and promote educational work in this field similar to that of the National Association for the Study and Prevention of Tuberculosis. Biological research, the treatment of individual cases and the main- tenance of hospitals or clinics are not comprehended in the design of the Society. Educational publicity is the first and the chief object. ' ITS ENDORSEMENTS The Society has received the official approval of the American Medical Association, the American Surgical Association, the American Gynecolog- ical Society, the Clinical Congress of Surgeons, the Western and South- ern Surgical Associations and the various special medical societies of national scope which together constitute the American Congress of Physicians and Surgeons. Numerous state and local medical societies have also given their endorsement and their active assistance in the work. 779 APPENDIX H Table 2 (concluded) Purpose and Methods of Work of The American Society for the Control of Cancer* Methods of Work PUBLICITY AND EDUCATION A press bureau, carefully supervised by distinguished medical experts, causes the regular publication of instructive articles in a large number of newspapers all over the country. Special articles are prepared for medical journals, health department bulletins and popular magazines. Leaflets and circulars are printed and distributed by mail, at meetings and through local agencies. The cooperation of boards of health, insurance companies, womens' clubs, industrial and welfare organizations and similar agencies is obtained and much additional educational work is thus stimulated. MEETINGS AND LECTURES Large public meetings have been organized in Chicago, St. Louis, Pittsburgh, Boston, Portland, New York and other cities. A lecture bureau has been established, and well-qualified speakers are supplied without expense for these and smaller meetings under the auspices of appropriate organizations. Special effort is made to instruct nurses and social workers as to the elementary facts about cancer, in order that they may spread this necessary and life-saving knowledge among the people, especially women, with whom they come in contact in the course of their duties. LOCAL WORK Branch committees of the National Society are set up in every city where the interest warrants such action. In organizing local campaigns the cooperation of state and city boards of health is particularly sought and health officials are furnished with facts, statistics and articles for educational work of their own in this field. STATISTICAL RESEARCH A series of special record forms has been prepared for use In various hospitals. A careful study of facts about the disease and the results of treatment is thus being made, and all new knowledge developed thereby will be given to the public. The cooperation of the United States Census Bureau, state boards of health and individual physicians has been obtained in improving the reporting and publication of cancer statistics. ♦Executive office, 105 East 22d St., New York, N. Y. 780 APPENDIX H Table 3 Instructions on Prevention of Cancer, Issued by the Borough of Portsmouth, England NOTICE IN REGARD TO CANCER Borough of Portsmouth It has been brought to the notice of the health committee that of the number of persons who die each year from cancer many could have been cured if they had applied earlier for medical advice. On questioning patients as to why they did not apply to a doctor earlier, the reason almost invariably given is that as the early symptoms were unaccom- panied by pain, it was not thought that anything serious was the matter. In order, therefore, to call the attention of the public to the signifi- cance of certain symptoms and conditions, and to the vital importance of acting promptly on the occurrence of these, it has been decided to make the following facts public : The only cure for cancer, at present known, is its early and com- plete removal. Cancer, if removed early, has been proved conclusively to be a curable disease. If neglected, and not removed in its earliest stage, it is practically invariably fatal. The paramount importance of its early recognition and early removal is, therefore, evident. For this purpose the assistance both of the public and the medical profession is requisite, and a grave responsibility rests on both. It is only by their mutual co-operation that the ravages of this terrible disease can be lessened. The following information should be of vital assistance to the public. It is no exaggeration to say that, if acted upon, the result would be the saving annually of many hundreds of lives, which at present are inevitably lost. 1. Cancer, in its early and curable stage, gives rise to no pain or symptom of ill-health whatever. 2. Nevertheless, in its commonest situations, the signs of it in its early stage are conspicuously manifest. To witness: 3. In case of any swelling occurring in the breast of a woman after 40 years of age, a medical man should at once be consulted. A large proportion of such swellings are cancer. 4. Any bleeding, however trivial, occurring after the change of life means almost invariably cancer, and cancer which is then curable. If neglected till pain occurs, it means cancer which is almost always incurable. 5. Any irregular bleeding occurring at the change of life should inva- riably be submitted to a doctor's investigation. It is not the natural method of the onset of the change of life, and in a large number of cases means commencing cancer. 781 APPENDIX H Table 3 (concluded) Instructions on Prevention of Cancer, Issued by the Borough of Portsmouth, England 6. Any wart or sore occurring spontaneously on the lower lip in a man over 45 years of age is almost certainly cancer. If removed at once the cure is certain, if neglected the result is inevitably fatal. 7. Any sore or swelling occurring on the tongue or inside of the mouth in a man after 45 years of age should be submitted to investigation without a moment's delay, and the decision at once arrived at by an expert microscopical examination whether it is cancer or not. A very large proportion of such sores or swellings occurring at this time of life are cancer, and if neglected for only a few weeks the result is almost inevitably fatal. If removed at once the prospect of cure is good. 8. Any bleeding occurring from the bowel after 45 years of age, commonly supposed by the public to be "piles," should be submitted to investigation at once. A large proportion of such cases are cancer, which at this stage is perfectly curable. 9. "^^Tien warts, moles, or other growths on the skin are exposed to constant irritation they should be immediately removed. A large number of them, if neglected, terminate in cancer. 10. Avoid irritation of the tongue and cheeks by broken jagged teeth, and of the lower lip by clay pipes. Many of these irritations, if neglected, terminate in cancer. 11. Although there is no evidence that cancer is communicable under ordinary circumstances, it is desirable that rooms occupied by a person suffering from cancer should be cleaned and disinfected from time to time. A. Mearns Feaser, M.D., Medical Officer of Health. Health Department, Town Hall, Portsmouth. January, 1914. 782 APPENDIX H Table 4 Report on the Prevention of Cancer of the Medical Officer of Health of the Borough of Shelf, England URBAN DISTRICT COUNCIL OF SHELF Report of the Medical Officer of Health on the Prevention of Cancer Very successful efforts are now being made to reduce the general death rate of this country by informing the public as to the methods of prevention of the most fatal forms of disease, and thereby obtaining their assistance. Until quite recently the lay public were kept in ignorance— except through occasional and not too accurate articles in the public press — of the vital subject of tuberculosis, but it is now realized that little harm and very much good has been done by teaching people how to prevent consumption. So, too, the prevention of cancer must not be delayed because of a few nervous persons, for it is perfectly possible to state some very important facts regarding cancer without provoking morbid self-examination or fear. The object of this report, therefore, is to give such facts in regard to this disease, which, if generally known and acted upon, would save very many lives annually. No cancer "parasite" has been found, and there seems much evi- dence to support the view that it is a natural response to injury. An overwhelming testimony of facts proves that the chief causative influence in its production is chronic irritation, i.e., it begins in a sore place, perhaps a mere crack, which does not quite heal up because, from its position, it cannot be kept clean or obtain perfect rest. Prevent this chronic irritation and you will prevent cancer ! Keeping in mind this all-important fact, the causation and prevention of the more common forms of cancer are here considered : The three more common situations are the breast, the stomach and the uterus. 1. Breast. — The evidence is very strongly in favour of the cause be- ing chronic irritation, the result of repeated "nursing" (lactation) and attacks of chronic inflammation due to "cracked nipples" which do not heal. Prevention. — Corsets which press the nipples inwards should be avoided, "cracked nipples" completely cured, and a doctor consulted early about any "lump" in the breast, whether this be painful or not. It may not be by any means necessarily a "growth," but it should receive treatment.' 2. Stomach. — About half the cases of cancer of the stomach de- velop at the seat of a neglected unhealed ulcer. Prevention. — Very persistent chronic indigestion should not be neg- lected too long. Continued "chronic irritation" anywhere is unde- sirable and should be avoided. Ulcers of the stomach, which are 783 APPENDIX H Table 4 (continued) Report on the Prevention of Cancer of the Medical OflBcer of Health of the Borough of Shelf, England often due to bad teeth and anaemia, must be permanently cured and not neglected, as is often the case, for years. 3. Uterus. — Cancer of this organ is almost exclusively confined to mothers and due to injuries at childbirth, which very simple remedies would heal. Prevention. — Irregular hemorrhage at the "change of life," and especially — though slight and unassociated with pain — occurring after the "change," renders it wise to consult a doctor. Such symptoms by no means necessarily imply cancer, but this disease can often be prevented if a medical man be consulted early under these circumstances. 4. Lip. — Its victims are nearly all smokers, its position on the lower lip and practically never on the upper one. It was very common when sticky clay pipes, which readily became hot, were used, and its cause is chronic irritation. Prevention. — It is a simple matter to see that little cracks about the lip, nose and ears are healed up. 5. Chimney-Sweep's Cancer. — This, which may occur in various parts of the body, is due to constant irritation of soot and dust. Em- ployees who work at gas and tar works, and who get their clothes saturated with irritating substances, are also liable to this disease. Prevention. — This form of cancer is not nearly so common now that sweeps are cleaner in their habits and work. It is wise to have warts, moles and papillary growths occurring on any part of the body removed. 6. Tongue and Mouth. — Warty and papillary growths and simple ulcers about the mouth are frequently due to chronic irritation from smoking, bad teeth, etc. Prevention. — When these are present, sources of irritation, e.g., hot liquids, alcohol, smoking, should be avoided. All broken or jagged teeth should be extracted, and any troublesome sore investigated. 7. Larynx. — The decrease in cancer of the "voice box" is due to the fact that those conditions which contribute to their development are now recognised early and reheved by treatment. Prevention. — The conditions here mentioned are the improper use of the voice, the abuse of alcohol and tobacco, and the presence of "innocent" warts. 8. Gullet. — Cancer of the "food pipe" usually follows upon chroiiic irritation of simple ulcers caused by indigestion or swallowing corrosive suh)stances or hot liquids. Prevention. — Simple ulcers should be healed and hot liquids should not be swallowed. 784 APPENDIX H Table 4 (concluded) Report on the Prevention of Cancer of the Medical Officer of Health of the Borough of Shelf, England 9. Intestine. — Most of these cancers are of the lower bowel, and no doubt due to the chronic irritation of constipation. Prevention. — It is wise to consult a doctor as to any bleeding from the bowel occurring in persons over 45 years of age. Of course this may be due to haemorrhoids ("piles"). Chronic constipation, as well as chronic diarrhoea, should be cured. 10. Gall- Bladder. — The chief danger of the long-continued presence of gallstones is the occurrence of cancer as an expression of continued irritation. Prevention. — Persons who have had gallstone colic should have the gallstones removed. This is not at all a serious operation. Cancer, if removed early, has been proved to be a curable disease, and the reason almost invariably given for not having seen a doctor earlier was that the early symptoms were unaccompanied by pain. Although cancer is probably not communicable under ordinary cir- cumstances, it is desirable that rooms occupied by a person suffering from cancer should be cleaned and disinfected from time to time. J. AspiNALL Marsden, M.O.H., Diploma in Pvblic Health. Urban District Council Offices, Shelf. July 1, 1914. 785 BIBLIOGRAPHY A complete list of the literature available in connection with the subjects specified in the table of contents has not been attempted. The present bibliography is limited to the more important works and articles consulted and made use of, most of which are in the library of The Prudential. The references relating particularly to life insurance and cancer have been separately listed, all being arranged alphabetically by authors or titles. Treatises published in book form are indicated by an asterisk placed before the author's name. Abbe, R. T., Cancer of the breast; Med. Rec, Mar. 31, 1900. Radium and surgery; Med. Rec, Aug. 15, 1914. Radium and surgery; Scientific American (supplement), Oct. 31, 1914. Abramowski, H., Tiber die Biologie des Krebses (On the biology of cancer); Ztschr.f. Krebsf., 1913, xiii, 345. Endemic incidence; Ztschr. f. Krebsf., 1907-08, vi, 394. Irritation and predisposition; Ztschr. f. Krebsf., 1910-11, x, 235. Adami, J. G., Cancer Research Institute; Jour. Am. Med. Assn., June 14, 1913. *Althaus, Julius, Electrolytic treatment of tumors and other surgical diseases; London, 1867. *Andrew, J. G., Age incidence, sex and com- parative frequency in disease; London, 1909. Andrews, Edmund, Supposed increase of cancer; Jour. Am. Med. Ass7i., June 24, 1899. Animal parasites in tumor formation; editorial. Jour. Am. Med. Assn., Apr. 5, 1913. *Arlidge, J. T., The hygiene, diseases and mortality of occupations; London, 1892. Arnold, H. S., Hemolysis in the diagnosis of malignant neoplasms; New Haven, 1913. Arnstein, Alfred, Ueber den sogenannten "Schneeberger Lungenkrebs" ; Wiener klin. Wochschr., Wien, May 8, 1913. Aronsohn, E., Tuberculosis and cancer; Deutsche Med. Wochschr., 1902, No. 47. Astro, P. v.. Cancer statistics of Utrecht; Ztschr.f. Krebsf., 1903-04, i, 268-270. Atlee, E., A suggested method for the early diagnosis of uterine cancer; Phila- delphia, 1912. Additional observations on the early diagnosis of uterine cancer; Phila- delphia, 1912. Austin, Annette, Public stupidity and can- cer increase; reprinted from De- lineator, Oct., 1912, by Kentucky State Board of Health. *Bainbridge, Wm. Seaman, The cancer problem; New York, 1914. Fulguration and thermo-radio therapy; New York, 1912. Possible errors in the diagnosis of ab- dominal cancer; address. Annual meet- ing, Med. Soc. of the State of New York, Rochester, Apr. 29, 1913. Transmissibility and curability; address, Rochester Academy of Medicine, Rochester, May 15, 1907. Trypsin treatment in cancer; N. V. Med. Jour., Mar. 2, 1907. Ball, C. F., Aberhalden's test in the diag- nosis of cancer; Jour. Am. Med. Assn., Oct. 3, 1914. Barabas, Jozsef, Contributions to the statistics of cancer localities; Ztschr.f. Krebsf., 1905, iii, 158. *Barnesby, Norman, Medical chaos and crime; London and New York, 1910. Bashford, E. F., The Bradshaw lecture on cancer; Brit. Med. Jour., Jan. 14, 1911. Cancer in animals and man; Berliner klin. Wochschr., 1909, Nos. 36, 37; also Med. Rec, Sept. 4. 1909. The cancer problem; Deutsche Med. Wochschr., 1913, Nos. 1, 2. *Comparative study of cancer; Trans, of San. Inst., 190i,v, 25. *Fifth scientific report of Imp. Can. Res. Fund; London, 1912. *Heredity and disease; Proc of Roy. Soc. of Med., London, November, 1908. Letter on fresh alarms on increase of cancer; Lancet, Feb. 7, 1914. 787 BIBLIOGRAPHY Local irritants and cancer; 3d scientific report of Imp. Can. Res. Fund, Lon- don, 1908; also Brit. Med. Jour., Sept. 3, 1910. *Real and apparent differences in inci- dence of cancer; Trans, of Epidemio- logical Soc, London, 1906-07, v, 25. Report as delegate to Second Interna- tional Conference on Cancer Research; Paris, 1910. Report of interview, with observations on American vital statistics; N. Y. Sun, Oct. 3, 1912. *Bashford and Cramer, Growth of cancer under natural and experimental con- ditions; 2d scientific report of Imp. Can. Res. Fund, London, 1905, part 2. and Murray, Zoological distribu- tion of cancer, etc.; 1st scientific report of Imp. Can. Res. Fund, London, 1904. *Statistical investigation of cancer; 2d scientific report of Imp. Can. Res. Fund, London, 1905, part 1. *Beale, O. C, Racial decay; London, 1911. Beatson, Sir George T., Cancer in Scotland; Brit. Med. Jour., June 15, 1912. *Beebe, S. P., Chemistry of cancer; Report of Collis P. Huntington Fund for Can. Res., New York, 1912, v, 3. Beitler, Frederic V., A discussion of cancer mortality; Jour. Am. Med. Assn., Oct. 16, 1915. *Bell, Benjamin, Treatise on the theory and management of ulcers : with a disserta- tion on white swellings of the joints; Edinburgh, 1789. *Bell, Robert, Cancer — its cause and treat- ment without operation; London, 1913, 2d edit., rev. Approaching conquest of cancer; Med. Rec, Feb. 16, 1907. Benedict, A. L., Cancer statistics; Med. Rec, Apr. 18, 1914. v. Bergmann, Ernst., Diseases which pre- cede cancer; Berliner klin. Wochschr., 1905, No. 30. Berkeley, W. N., Results of three years' clinical work with a new anti-serum for cancer; Med. Rec, Apr. 25, 1914. Bird, F. D., Conditions simulating cancer of the stomach; Brit. Med. Jour., Oct. 1, 1910. *Blaiklock, George, Alcohol factor in social conditions; London, 1914, p. 37. Bland-Sutton, Sir John, On cancer of the duodenum and small intestine; Brit. Med. Jour., Oct. 17, 1914. *Gall-stones and diseases of the bile- ducts; New York, 1908. Bloodgood, Joseph C, Control of cancer; Jour. Am. Med. Assn., Dec. 27, 1913. Observations on cancer of the tongue; Southern Med. Jour., July, 1914. Surgery, gynecology, obstetrics and gen- ito-urinary diseases; Southern Med. Jour., July, 1915. Surgical treatment of cutaneous malig- nant growths; Jour. Am. Med. Assn., Nov. 5, 1910. What every one should know about can- cer. No. 1; The cancer problem. No. 6; Control of cancer. No. 7; Prevention of cancer series. Council on Health and Public Instruction, Am. Med. Assn., Chicago, 1914-15. Boggs, R. H., Modern trend in the treat- ment of malignancy; A^. Y. Med. Jour., June 13, 1914. Boldt, H. J., Observations on the possible reduction of the mortality from cancer of the uterus, with special reference to treatment and publicity through the lay press; Jour. Am. Med. Assn., Mar. 29, 1913. Borrmann, Robert, Statistics concerning histologically investigated skin can- cers; Deutsche Ztschr. f. Chir., v, 76, parts 4-6. *Boudin, J. C. M., Treatise on geography, medical statistics and endemic dis- eases; Paris, 1857, 2 vols. Bovee, J. W., Status of the fight against cancer of the uterus; Jour. Am. Med. Assn., Sept. 21, 1907. Bowen, John T., Precancerous dermatosis; Jour. Cutaneous Diseases, Dec. 1915. Brand, A. T., Problem of causation; Practitioner, 1903, v, 72, No. 4, p. 579. Branthwaite, R. W., Report of inspector under inebriates act, for year 1909; London, 1911. Bristol, L. D., Problem of cancer etiology; Med. Rec, May 3, 1913. Bristow, A. I., Hypothesis of Cohnheim concerning carcinoma; Brooklyn Med. Jour., October, 1903, xvii, 444. 788 BIBLIOGRAPHY Buday, K., Statistics of cancer and malig- nant tumors — Pathological and Ana- tomical Institute of the University in Kolozsvar; Ztsckr. f. Krebsf., 1907-08, vi, 1. Bulkley, L. D., Relation of diet to cancer; Med. Rec, Oct. 24, 1914. *Cancer — its cause and treatment; New York, 1915. Medical aspects of cancer; Med. Rec, May 15, 1915. Bull, W. T., On the cure of carcinoma of the breast by radical operation; Med. Rec, Aug. 25, 1894. *Bullock, F. D., Notes on the growth of tissues under experimental conditions; Report of George Crocker Spec. Res. Fund, 1913, iii, 59. *Spontaneous tumors; Report of George Crocker Spec. Res. Fund, 1913, iii, 66. -, Rohdenburg and Johnson, Re- lation of internal secretions to malig- nant tumors; Report of George Crocker Spec. Res. Fund, iii, 87. Burn, Joseph, Vital statistics explained; London, 1914. Burrus, J. T., On operable and inoperable cancer of the uterus; Charlotte (N. C.) Med. Jour. *Butler, G. R., Diagnostics of internal medi- cine; New York and London, 1905. Butlin, H. T., Results of operations for carcinoma of the tongue; Brit. Med. Jowr., Jan. 2, 1909. Two lectures on unicellula cancri: the parasite of cancer; Brit. Med. Jour., Nov. 25 and Dec. 2, 1911. *Cabot, R. C, Differential diagnosis; Phila- delphia and London, 1912, 2d edit. *Physical diagnosis; New York, 1910, 4th edit. Cameron, Sir Hector C, Some clinical facts regarding mammary cancer; Brit. Med. Jour., Mar. 6, 1909. *Campbell, Harry, The causation of dis- ease; London, 1889. Cancer; Monthly review of the Inter- national Assn. for Can. Res., Berlin, 1912-14. of the appendix; editorial. Jour. Am. Med. Assn., Jan. 14, 1911. cell; editorial, Med. Rec, Dec, 16, — census of German Empire; Klin. Jahrbuch, 1 Ergzsbd., .lena., 1902. census of Greece (Larissa); Ztschr. f. Krebsf.. 1903-04, i, 292. census of Sweden; Ztschr. f. Krebsf., 1908-09, vii, 3. cure fraud; reprinted with modifi- cations and additions from Jour. Am. Med. Assn., Chicago. , early treatment of, and cure; Metropolitan Life Ins. Co., New York, 1914. houses ; Lancet, Apr. 18 and May 30, 1914. — houses; Jour. Am. Med. Assn., Jan. 9, 1915. in Index-catalogue of the Surgeon- General's Library, U. S. A., Washing- ton, 1898, vol. iii. and precancerous conditions; edi- torial, Med. Rec, Mar. 7, 1914. — in Reference Handbook of the Medical Sciences, ii, 595, et seq. — research in Australia; Empire Re- view, Mar., 1904, vol. vii. statistics of Amsterdam; published by Municipal Bureau of Statistics, Amsterdam, 1911. statistics in Michigan; 35th annual 1911. report on registration of births and deaths, for year 1901, pp. 72-89. symposium; Michigan State Board of Health, Nov., 1915. and what you should know about the disease of middle life and old age; North Carolina State Board of Health, Special Bull. No. 37, Raleigh, N. C, February, 1915. *Catalogue of cancer exhibit; Interna- tional Hygiene Exposition, Dresden, 1911. *Cathcart, C. W., Essential similarity of innocent and malignant tumors; New York, 1913. Chalmers, A. J., and Christopherson, J. B., Article on peculiar form of spreading cutaneous wart (murkekiasmosis am- philaphes); Jour. Trop. Med. and Hyg., May 1914, vol.xvii. No. 9. Cheyne, Sir W. Watson, Diagnosis and treatment of malignant disease of the breast; Med. Rec, Aug. 22, 1908. *Childe, Charles P., The control of a scourge, or how cancer is curable; London, 1906. 789 BIBLIOGRAPHY Cancer, public authorities and the public; Brit. Med. Jour., Mar. 21, 1914, p. 643. *Chittenden, Russell H., Physiological economy in nutrition; New York, 1904. Chute, A. L., Operation in cancer of the bladder; Jour. Am. Med. Assn., Dec. 26, 1914. Clark, A. Schuyler, Radium treatment of cutaneous epitheliomas; Jour. Am. Med. Assn., May 9, 1914. Clark, J. G., Treatment of cancer of the uterus by Roentgen rays; Med. Bull., University of Pennsylvania, Nov., 1903. *Clark, J. J., Rhizopod Protozoa: the cause of cancer and other diseases. New York, 1915. Clark, W. L., Desiccation treatment of congenital and new growths of the skin and mucous membranes; Jour. Am. Med. Assn., Sept. 12, 1914. *Clemow, F. G., The geography of disease; London, 1903, pp. 59-72. Clevenger, J. F., Effect of soot in smoke on vegetation; Bull. No. 7, Smoke in- vestigations, Mellon Institute of In- dustrial Research, Pittsburgh, 1913. Coe, Henry C, Cancer of the uterus; Med. Rec, Mar. 31, 1900. * Cohen and Ruston, Smoke — a study of town air; London, 1912. Cohnheim, Paul, Constitution of the body in cancer of the digestive organs; Ztsehr.f. Krebsf., 1910-11, x, 317. Cole, L. G., Positive and negative diagnosis of gastric cancer; A'^. Y. Med. Jour., Feb. 14, 1914. Coley, Wm. B., Observations on the in- crease of cancer; address. Southern Surg, and Gyn. Assn., Dec. 14, 1909. Injury as a causative factor in cancer; Report of CoUis P. Huntington Fund for Can. Res. New York, 1912. *Collie, Sir John, Malingering and feigned sickness; London, 1913, pp. 127, 217, 241, 271, et seq. Couch, L. B., Traumatism as a cause of cancerous growths; A''. Y. Med. Times, Nov., 1911. Coughlin, W. T., Sarcoma of the tongue; Jour. Am. Med. Assn., Jan. 23, 1915, p. 291. *Councilman, W. T., Disease and its causes; New York and London, 1913. Couzis, Observations on cancer by the doctors of Greek antiquity; Athens, 1903; also Ztsehr.f. Krebsf., 1903-04, i, 264. Cresswell, Lionel, Oxygen and cancer, a biological and chemical study; Nine- teenth Century and After, May, 1914. Crile, G. W., The cancer problem; Jour. Am. Med. Assn., June 6, 1908. Crow, D. A., Chimney-sweeps' cancer; Brit. Med. Jour., Feb. 21, 1914. Cullen, T. S., Surgical pathology of cancer; Med. Rec., Apr. 26, 1913. *Cancer of the uterus. New York, 1900. Early diagnosis of cancer of the uterus; Pennsylvania Med. Jour., Nov., 1909. Cunningham, J. H., Operative treatment of carcinoma of the penis; Surg., Gyn. and Obst., Dec, 1914, pp. 693-699. Cunningham, W. P., Epithelioma varium; A^. Y. Med. Jour., Nov. 28, 1914, p. 1057. Czerwenka, K., Primary cancer of both breast and uterus; Wiener Med. Wochschr., May 2, 1914. Dagonet, G., Transferableness of cancer; Arch, de Med. Experimentale, 1904, No. 3. Davis, Benj. Franklin, Paraffin cancer; Jour. Am. Med. Assn., May 30, 1914. Davis, G. G., Etiology of Buyo cheek cancer; Jour. Am. Med. Assn., Feb. 27, 1915, p. 711. Delafield, Francis, On cancer and cancer cells; Med. Rec, 1871. * and Prudden, Text-book of Pathology; New York, 1912, 9th edit. Delano, Samuel, Radium therapy; Boston Med. and Surg. Jour., Jan. 29 and Feb. 5, 1914. Dennis, F. S., Report on end-results follow- ing operations for cancer of the breast; Surg., Gyn. and Obst., July, 1907. Treatment of malignant disease; Trans. of Connecticut State Med. Soc, Hart- ford, May 25, 1905. *Diagnosis of cancer; articles. Report of George Crocker Spec. Res. Fund; 1913, iii, ICO. Dispensary treatment for cancer patients in Germany; Ztschr. f. Krebsf., 1904., ii, 192. *Dollinger, Julius, Observations on Hun- garian cancer census; Budapest, 1908; also Ztsehr.f. Krebsf, 1908-09, vii, 276. Some striking results of the cancer census of Hungary; Ztsehr.f. Krebsf., 1907, v, 127. 790 BIBLIOGRAPHY Douglas, Archibald, National Radium In- stitute; Mining and Scientific Press, Jan. 3, 1914. *Drysdale, C. V., Observations on preven- tion of conception and cancer {in The sniall family system. New York, 1914, V, 72). Dupuich, M., Cancer of the tongue in young people; Rev. de Chir., Mar., 1913. Education of the public regarding cancer menace; editorial, Med. Rec, June 21, 1913. Edwards, Roy F., General death rate from malignant growths in principal Ameri- can cities; N. Y. Med. Jour., Dec. 18, 1909. *Emerson, C. P., Clinical diagnosis; Phila- delphia, 1913, 4th edit. *Encyclopedia Britannica, Article on can- cer, 9th edit., iv, 800. Etiology of cancer; editorial, Med. Rec, May 6, 1905. *Evans, Willmott, Medical science of to- day; Philadelphia, 1912. Ewing, James, Animal experimentation and cancer; Jour. Am. Med. Assn., Jan. 22, 1910. Cancer Research Hospital; A'^. Y. Med. Jour., Dec. 27, 1913. Precancerous diseases and lesions; Med. Rec, Dec. 5, 1914. Fakers (cancer). Report on eight concerns against which the U. S. Post-office has issued fraud orders; Am. Med. Assn., Chicago, 1913. Reports reprinted with modifications and additions from Jour. Am. Med. Assn., Chicago, 1913. Falk, Edmund, Statistics of cancer of the uterus; Ztschr. f. Krebsf., 1910-11, x, 267. *Falta, Wilhelm, Ductless glandular dis- eases (translation by Milton K. Mey- ers), Philadelphia, 1915, p. 54. *Farr, William, Vital statistics; London, 1885. Fischer-Defoy, Dr., Early clinical diagnosis of cancer; Ztschr. f. Krebsf., 1911, xi, 65. *Fishberg, Maurice, Observations on cancer among the Jews (in his The Jews; New York, 1911, p. 311, et seq.). Fishes, occurrence of cancer among; House of Representatives Document No. 848, Washington, 1910, Foote, E. M., Partial resection of the lower jaw for cancer; .4 m . Jour. Med. Sciences, July, 1915. Fordyce, J. A., Pathology of malignant epithelial growths of skin; Jour. Am. Med. Assn., Nov. 5, 1910, Forrest, Erie D., The physiology of worry; Scientific American (supplement), Jan. 9, 1915. Francis, C. D. D'A., A biological treatment for cancer; May 9, 1914. Frazier, C. H., Sarcoma of the stomach; Am. Jour. Med. Sciences, June, 1914. Free Cancer Hospital of Brompton; Annual reports, 1909-13, London. *French, Herbert, Carcinoma of left kidney; Guys Hosp. Rpts., London, 1912, series iii, vol. li. *An index of differential diagnosis of main symptoms (by various writers, edited by French); New York, 1913. *French, James M., A text-book of the practice of medicine (revised by Charles Spencer Williamson); New York, 1910, 4th edit. Frequency of cancer in Brazil; Ztschr. f. Krebsf., 1904, ii, 407. Freund, Wilh. Alex., Natural history of cancer; Ztschr. f. Krebsf., 1905, iii, 1. Friedenwald, Julius, Clinical study of one thousand cases of cancer of the stomach; Am. Jour. Med. Sciences, Nov., 1914. Galli, G., On the increase in weight in cancer of stomach; La Clinica Medica Italiana, 1904, No. 5; also Ztschr. f. Krebsf., 1905, iii, 600. *Gardner, Faxton E., Iconograms, or a collection of colored plates illustrating interesting surgical cases, with ex- planatory text; New York, 1913. *Gaucher, Ernest, Diseases of the skin; London, 1910, pp. 186, 267, 440. Gavalas, S. A., Spread of cancer in Greece; Ztschr. f. Krebsf., 1908-09, vii, 605. Gaylord, Harvey R., Etiology of cancer; Jour. Am. Med. Assn., Mar. 20, 1915. Laboratory experiments on causation of cancer; Jour. Am. Med. Assn., July 18, 1908. Observations in support of parasitic theory of cancer; 6th annual report of Cancer Laboratory of the New York State Dept. of Health, Albany, 1907. 791 BIBLIOGRAPHY *Gaylord and Marsh, Carcinoma of the thyroid in salmonoid fishes; Bull. U. S. Bureau of Fisheries, Washington, 1914. General Memorial Hospital, New York; Annual reports, 1885-1913. German Central Cancer Committee's rules and regulations for study of and campaign against cancer. Giles, A. E., A plea for early operation in cases of uterine fibroids; Brit. Med. Jour., Oct. 18, 1913. Gilford, Hastings, On the nature of old age and cancer; Brit. Med. Jour., Dec. 27, 1913. *The disorders of post-natal growth and development; London, 1911. Glosser, H. H., and Frisbie, W. S., Studies in metabolism of cancer patients as compared with normal individuals; Jour. Am. Med. Assn., Feb. 24, 1906. Gold, J. D., Syphilis and cancer; Yale Med. Jour., Oct., 1911. *Golebiewski, Ed., Atlas and epitome of diseases caused by accidents; Phila- delphia, 1900. Goodbody, F. W., Electrical forces of mitosis and the origin of cancer; Mar. 21, 1909. Gordon, William, The factor of common- ness in the diagnosis of cancer; Brit. Med. Jour., Nov. 11, 1911. and Thompson, W. F., Distribu- tion of cancer cases in two registration districts of northeast Cornwall; Brit, Med. Jour., Aug. 30, 1913. Gorse and Dupuich, Cancer of the tongue in early life; Rev. de Chir., Mar. 1913. Gould, Sir Alfred Pearce, Bradshaw lecture on cancer; Brit. Med. Jour., Dec. 10, 1910. Radium and cancer; Brit. Med. Jour., Jan. 3, 1914. and others. Discussion on radium and radiotherapeutics, chiefly in ma- lignant growths; Brit. Med. Jour., Oct. 11, 1913. *Gould, George M., An illustrated diction- ary of medicine, biology and allied sciences; Philadelphia, 1907. *Green, C. E., Local incidence of cancer; Edinburgh, 1912. *The cancer problem, a statistical study; Edinburgh, 1911; also 3d edit., 1914. A study of the local incidence of cancer in Nairnshire; Edinburgh Med. Jour., Oct., 1912. Greenough, Robert B., Cancer; Am. Soc. for Cont. of Can., New York, 1915. *Greer, W. J., Industrial diseases and acci- dents; Bristol and London, 1909. Gross, S. W., Treatise on tumors of the mammary gland; New York, 1880. Griinbaum, Albert S., Germ-cell theory of cancer; Brit. Med. Jour., 1904, ii, 1634. Giissow, H. T., Potato canker transmitted by use of unsound seed potatoes; Bull., Dominion Botanist, Ottawa, Canada, Apr., 1914. Guthrie, Donald, Rodman operation for breast cancer; Jour. Am. Med. Assn., Oct. 10, 1914. *Haaland, M., Spontaneous tumors in mice; 4th scientific report of Imp. Can. Res. Fund, London, 1911. Haberfeld, Walther, Statistics and etiology of cancer of stomach, gall-ducts and bronchi; Ztschr.f. Krebsf., 1908-09, vii, 190. *Hanes, F. M., and Lambert, R. A., Prob- lem of spread of malignant growths of the body; Report of George Crocker Spec. Res. Fund, 1912, ii, 159. V. Hansemann, D., Cancer terminology; Ztschr.f. Krebsf., 1913, xiii, 1. Harnsberger, Stephen, Cancer in Virginia; Virginia Med. Semi-Monthly, Rich- mond, Sept. 23, 1910. Harris, Philander A., Cancer education of the public; Med. Rec., Mar. 31, 1900. *Harvard Cancer Commission, 2d, 3d, 4th and 5th reports; Boston, 1905, 1907, 1909, 1913-14. Hatch, J. LeflSngwell, Cancer: its origin and successful treatment; Med. Exam., July, 1914. *Haviland, A., Geography of heart disease, cancer and phthisis; London, 1875, pp. 63-90. *0n the ill effects of floods on health; Trans, of San. Inst., London, 1890, xi, 248-249. *Thc geographical distribution of disease in Great Britain; London, 1892, 2d edit. 792 BIBLIOGRAPHY Hazen, Henry H., Cancer of the skin; No. 4, Prevention of cancer series, Council on Health and Public Instruc- tion, Am. Med. Assn., Chicago, 1914- 15. *Diseases of the skin; St. Louis, 1915, pp. 463-509. *Heim, Gustav, Analysis of causes and conditions of pathological processes; Virchows Arch., 1914, ccxvi, 1, et seq. Hemic cause of carcinoma; editorial, Med. Rec. Feb. 6, 1909. *Hendriks, Frederick, Pamphlets on vital statistics, 1860-65; London (Prudential Library) . Heredity and trauma as factors in cancer occurrence; editorial. Jour. Am. Med. Assn., Oct. 24, 1903. and trauma in intestinal carci- noma; Therajp. Wochschr., July 4, 1897. Heron, David, Second study of extreme alcoholism in adults; Eugenics Labora- tory Memoirs, London, 1912, pp. 23, 24. Herzfeld, Dr., Tumor and trauma; Ztschr. f. Krebsf., 1905, iii, 73. Hill, Bertram, Vital statistics of Ceylon; Civil Administration Reports, 1913, parti, p. 12. *Hirsch, August, Handbook of geographical and historical pathology (translation by Chas. Creighton); London, vol. i, 1883; ii, 1885; iii, 1886. Hislop, P. W., and Fenwick, P. C, Cancer in New Zealand; Brit. Med. Jour., Oct. 23, 1909. Hoeber, W. R., Relation of soil to tumor growth; Ztschr. f. Krebsf., 1903-04, i, 173. Hoffman, Frederick L., The cancer death rate; The Spectator (life insurance sup- plement). New York, May 22, 1913. The accuracy of American cancer mortal- ity statistics; reprinted from .4m. Jowr. Pub. Health, vol. v. No. 6. Address on the menace of cancer; re- printed from Trans, of Am. Gyn. Soc, 1913. American public health problems; Panama-Pacific Exposition Memorial Publication No. 4, The Prudential Ins. Co., Newark, N. J., 1915. Cancer death rate in selected occupa- tions; Bull. Am. Acad, of Med., Oct., 1914; also Eastern Undenvriter, June 25, 1914. The chances of death and the ministry of health; address, Yale Divinity School, New Haven, Conn., Mar. 30, 1914, p. 10. Industrial accidents and trade diseases in the United States; Trans, of 15th International Congress on Hygiene and Demography, Washington, Sept. 23- 28, 1912. The menace of cancer and American vital statistics; letter. Lancet, Apr. 11, 1914. Mortality of the western hemisphere; Panama-Pacific Exposition Memorial Publication, No. 3, The Prudential Ins. Co., Newark, N. J., 1915. The present position of municipal and vital statistics in the United States; Trans, of 15th International Congress on Hygiene and Demography, Washing- ton, Sept. 23-28, 1912, p. 6. *Race traits and tendencies of the Amer- ican negro; Am. Economic Assn. Pub- Ucations, New York, 1896, p. 116, et seq. Rural death rate of the state of New York; State Dept. of Health, Albanj', N. Y., 1913, pp. 12, 26, 40, 49. Rural health and welfare, with observa- tions on cancer; special publication. The Prudential Ins. Co., Newark, N. J., 1912, pp. 9, 15. Significance of a declining death rate; The Prudential Ins. Co., Newark, N. J., 1914, p. 32, Some elements of vital statistics, with observations on cancer; Bull. No. 1, Vermont State Board of Health, Sept. 1, 1911, vol. xii, p. 16. *Some essential statistics of cancer mor- tality throughout the world; Com- memoration Volume, Am. Med. Assn., Chicago, 1915, pp. 317-332, reprinted by Am. Soc. for the Cont. of Can. The statistical experience data of the Johns Hopkins Hospital, Baltimore, Md.; monograph, Baltimore, 1913, new series. No. 4. Vital statistics of the Census of 1900; address. Am. Stat. Assn., Boston, Jan. 16, 1903, pp. 165-167. Holding, Arthur F., Treatment of cancer by electrical methods; N. Y. Med. Jour., Sept. 19, 1914. *Horsley, Sir Victor, and Sturge, Mary D., with chapter by Arthur Newsholme, Alcohol and the human body; London, 1907, p. 349. 793 BIBLIOGRAPHY Hubbard, J. C, Remote metastases follow- ing cancer of the breast; Boston Med. and Surg. Jour., July 4, 1912. Himiiston, W. H., Importance of early recognition of cancer of the uterus; Jour. Am. Med. Assn., Sept. 29, 1900. Hurty, J. N., Cancer in Indiana; Jour. Indiana State Med. Assn., July, 1915. *Hutchinson, Woods, Preventable diseases; Boston and New York, 1909, 3d edit., p. 350, et seq. Hvoslef, A., Cancer in the rural districts of Norway; Ztschr.f. Krebsf., 1908-09, vii, 184. Imperial Cancer Research Fund, Annual report; Brit. Med. Jour., Aug. 2, 1913; also Lancet, Aug. 9, 1913. Twelfth annual report; July, 1914. *Imperial Cancer Research Fund, Scientific reports on the investigations of — 1st to 5th; London, 1904-12. *Index of joint causes of death; Bureau of the Census, Washington, 1914. *Intemational statistics of cancer {in Statistique Internationale du Mouve- ment de la I^spulation d' apres les Registres de L'fitat Civil, 2 vols., Paris, 1907, 1913; Statistique Demographique des grandes Ville du Monde, 1880-1909, Bureau Municipal de Statistique d' Amsterdam; annual reports of Registrar-General of Births, Deaths and Marriages in England and Wales; also vol. iii, Wolff, J., Lehre von der Krebskrankheit, Jena, 1913). Janeway, H. H., Results of radimn in cancer; Jour. Am, Med. Assn., May 30, 1914. *Jeffreys, W. Hamilton, and Maxwell, J. L., Diseases of China, containing obsen^a- tions on cancer in China; London, 1910. Joseph, Eugene, Inherited malignant growths; Deutsche Med. Wochschr., 1903, No. 35. Joslin, E. P., End-results in cases of gastric and- duodenal ulcer; Jour. Am. Med. Assn., Nov. 21, 1914. Judd, E. S., End-results in operations for cancer of the breast; Med. Rec, Feb. 21, 1914. Kansas State Medical Society, Bull, on cancer; Kansas City, 1914. *KeUy, H. A., Appendicitis and other dis- eases of the vermiform appendix; Philadelphia and Ix)ndon, 1909. The present status of operations for cancer of the uterus; Jour. Am. Med. Assn., May 19, 1900. *Kenwood, H. R., Observations on the action which may be taken by medical officers of health in investigating the origin of cancer; Trans, of San. Inst., London, 1902, voL xxiii. *King, George, and Newsholme, Arthur, On the alleged increase of cancer; Proc. of Roy. Soc. of Med., London, 1893, liv, 209. Kirbey-Smith, J. L., Observations on skin cancers; Southern Med. Jour., Oct., 1914. Kirchner, Dr., Aim and object of German Central Committee for Cancer Re- search; Ztschr. f. Krebsf, 1910-11, X, 3. Klug, O., Mould as a pathological parasite and a cause of cancerous growths; Ztschr. f Krebsf, 1903-04, i, 132. Knibbs, G. H., Secular progress of tuber- culosis and cancer in Australia; Sydney, 1913. Krasting, Karl, Contribution to the sta- tistical study of cancer causation, with special reference to metastases in the central nervous system; Ztschr. f. Krebsf, 1906, iv, 315. Kudo, T., Primary cancer of the appendix; Ztschr. f. Krebsf, 1907-08, vi, 402. Lakeman, Curtis E., Cancer as a public health problem; published by Am. Soc. for the Cont. of Can., June, 1914. Cancer a social problem; reprinted by Am. Soc. for the Cont. of Can., New York, 1915. Laspeyres, R., Contribution to cancer statistics; Centralblatt f. a. Gesund- heitspflege, 1901, xx, 342. *Lathrop, A. E. C, and Loeb, Leo, Inci- dence of cancer in various strains of mice; Proc. of Soc. for Expert. Biol, and Med., 1913. ^Influence of pregnancies on incidence of cancer in mice; Proc. of Soc. for Experi. Biol, and Med., 1913, xi, 38-40. *Laurence, J. Z., Diagnosis of surgical cancer, Liston Prize Essay for 1854, London, 1855. *Lawes, E. T. H., Law of compensation for industrial diseases; London, 1909. 794 BIBLIOGRAPHY Lazarus-Barlow, W. S., Cause and cure of cancer in the liglit of radio-biological research; Brit. Med. Jour., May 9, 1914. Croonian lectures on radio-activity and carcinoma; Brit. Med. Jour., June 19 and 2G, 1909. Evidence yielded by statistics of Mid- dlesex Hospital on the question of increase of cancer; Med. Exam., Dec, 1905. *Reports from the cancer research laboratories, including statistics of post-mortem examinations and opera- tions in cases of malignant disease; Arch, of Middlesex Hasp., London, 1910, xix, 1. Leaf, Cecil IL, Causes of cancer of the breast; Ztschr. f. Krebsf., 1907, v, 129. Le Conte, John, Statistical researches on cancer; Southern Med. and Surg. Jour., May, 1846. Vital statistics as illustrated by laws of mortality from cancer; Western Lancet, 1872. Ledoux-Lebard, Control of cancer in the past, present and future; Ztschr. f. Krebsf., 1907, v, 247. Legge, T. M., Special report on ulceration of skin and epitheliomatous cancer in the manufacture of patent fuel; Lon- don, 1910. Leitch, Archibald, Serum diagnosis of pregnancy and cancer; Brit. Med. Jour., July 25 and Aug. 15, 1914. Leuenberger, S. G., Tumors developing in urinary apparatus of workers on synthetic dyes; Klin. Chir., Tubingen, XXX, No. 2. *Levin, Isaac, Cancer among the American Indians and its bearing upon the ethnological distribution of the disease; Report of George Crocker Spec. Res. Fund, 1912, ii, 57. *Etiology of cancer of the uterus; Report of George Crocker Spec. Res. Fund, 1912, ii, 15. *Influence of heredity on cancer; Report of George Crocker Spec. Res. Fund, 1912, ii, 129. Relation between surgical treatment and radiotherapy of cancer; Med. Rec, Oct. 10, 1914. *Study of cancer etiology based on clinical statistics; Report of George Crocker Spec. Res. Fund, 1912, ii, 29. V. Leyden, E., Investigations regarding can- cer parasites; Ztschr. f. Krebsf., 1903-04, i, 293. Leyden, Hans, Observations on cancer census of Spain; Ztschr. f. Krebsf., 1903-04, i, 41. Observations on the supplementary can- cer census of Germany; Ztschr. f. Krebsf., 1907, v, 494. Liek, — ., Statistics of. inoperable cancer of the uterus; Monatschriftf. Geburtsh. u. Gyndkol., vol. xx, part 2. Lindemann E., Cancer statistics of Heligo- land; Ztschr. f. Krebsf., 1903-04, i, 225. Lilienthal, Howard, Suspicion of malig- nancy; Boston Med. and Surg. Jour., Jan. 22, 1914. Ljunggren, A., Cancer of the gall-bladder; Nordisk. Tidshrift. for Terapi., Jan., 1904, part 4; also Ztschr. f. Krebsf., 1903-04, i, 378. *Lockwood, C. B., Cancer of the breast; London, 1913. Objections to incomplete operations for cancer of the breast; Brit. Med. Jour., May 23, 1914. Loeb, Leo., Etiology of cancer of the skin; Jour. Am. Med. Assn., Nov. 5, 1910. Present status of cancer research; Popular Science Monthly, Jan., 1914. Recent progress and present status of experimental research in cancer; Jour. Am. Med. Assn., Oct. 29, 1910. Summary of investigations in tumor growth; Interstate Med. Jour. 1913, vol. XX, No. 5. and Fleisher, M. S., Investigations into the inheritance of determining factors in tumor growth; Centralblatt f. Bakteriol, 1912, v, 67. *Longstaff, G. B., Studies in statistics, social, political and medical; London, 1891. Lush, A. H., Official reports on draft regu- lations proposed to be made for the manufacture of patent fuel with ad- dition of pitch; 1st and 2d reports, London, 1911, 1913. *MacCallum, Wm. C, Cancer pathology; Report of George Crocker Spec. Res. Fund, 1912, ii, 1. Mackenzie, K. A. J., Personal experience with radium in treatment of cancer; Northwest Med., Seattle, Sept., 1914. *Magruder, E. W., Claims arising from re- sults of personal injuries; New York, 1910. 795 BIBLIOGRAPHY Mallorj', F. B., Contribution to classifica- tion of tumors; Jour. Med. Res., Jan., 1905. Manges, Morris, The general practitioner's responsibility in the early diagnosis of cancer; Am. Soc. for the Cont. of Can., New York, Oct., 1915. Manson, J. S., Hereditary transmission of sarcoma; Brit. Med. Jour., Nov. 1, 1913. *Manual of the International List of Causes of Death; Paris, 1909, 2d rev. Marino, Eduardo, Observations on cancer mortality of Buenos Aires; Ztschr. f. Krebsf., 1910-11, x, 277. Martin, F. A., Early diagnosis and treat- ment of cancer; Bull. 16, University of Missouri, Columbia, 1915, vol. xxi. Martin, Franklin H., Cancer of the womb; No. 2, Prevention of cancer series. Council on Health and Public Instruc- tion, Am. Med. Assn., Chicago, 1914- 15. Massey, G. B., Some aspects of the cancer problem; Med. Rec, July 1, 1905. Matas, Rudolph, Surgical peculiarities of the American negro. Trans, of Am. Surg. Assn., 1896. Matthes, M., Statistical examination of the sequelae of syphilis; Med. Rec, Mar. 15, 1902. Maynard, G. D., Statistical study in cancer death rates; Biometrika, Apr., 1910, p. 277. Mayo, C. H., Prophylaxis of cancer; Jour. Am. Med. Ass7i., Nov. 5, 1910. Mayo, W. J., Operative treatment of cancer of the stomach; Jour. Am. Med. Assn., Aug. 23, 1913. The cancer problem; Journal-Lancet, July 1, 1915. Prophylaxis of cancer; Report of annual meeting of Am. Surg. Assn., Apr. 9-11, Med. Rec, 1914, p. 1142. McConnell, G., Cancer in the United States of North America; Ztschr. f. Krebsf., 1908-09, vii, 238. McDowell, W., Origin of cancer and its control; N. Y. Med. Jour., Feb. 18, 1911. McGraw, T. A., Our present knowledge of tumors and cancers; Jour. Am. Med. Assn., Sept. 7, 1895. Menace of cancer and American vital statistics; Lancet, May 9, 1914. *MetchnikofiF, Elie, Nature of man; New York and London, 1903, pp. 73, 74, 213, 214. *Prolongation of life; New York and London, 1908, p. 144. Meyer, George, Report on ten years' work of German Central Committee for Cancer Research; Ztschr. f. Krebsf., 1910-11, X, 8. Report of German Central Committee for cancer research, 1910-11; Berlin, 1912. Meyer, Willy, Public cancer education; Med. Rec, Oct. 11, 1913. Michigan State Board of Health Bull, on cancer and how it can be cured; Lansing, July-Sept., 1909. *Miller, James, Practical pathology, in- cluding morbid anatomy and post- mortem technique; New York, 1914, p. 297. *Minot, C. S., The problem of age, growth and death; New York and London, 1908. Montaigne, A., Cancer and its cause; New .York, 1915. Montgomery, E. E., How can we lessen the mortality from cancer of the uterus; Jour. Am. Med. Assn., Sept. 21, 1907. Moore, John T., Pessimism concerning the treatment of cancer; Houston, 1914. Morison Rutherford, Tuberculosis, syphilis and malignant disease; Brit. Med. Jour., Nov. 19, 1910, p. 1573, Morris, Henry, Cancer and its origin; Brit. Med. Jour., Dec. 12, 1903, p. 1505. Moullin, C. Mansell, Biology of tumors; Brit. Med. Jour., Dec. 7, 1912. Biology of tumors; Lancet, Mar. 21, 1914. *Murray, J. A., Ancestry and incidence of cancer in mice; 4th scientific report of Imp. Can. Res. Fund, London, 1911. *Mussey, W. H., On treatment of cancer by electrolysis; Trans, of Am. Med. Assn., 1872, vol. xxiii. Nagle, — ., Concerning causes of cancer spread; Med. Korrespondenzblatt des u'urttember-drtzl. Landesvereins, Oct. 22, 1904; also Ztschr. f. Krebsf., 1905, iii, 603. Nagle, J. D., Tuberculosis and cancer; Med. Exam, and Prac, Oct., 1900. 796 BIBLIOGRAPHY Nash, W. G., Cancer houses; Lancet, Apr. 18, 1914. Neve, Ernest F., Cancer causation as illus- trated by epithelioma in Kashmir; Brit. Med. Jour., Sept. 3, 1910. Neves, Azevedo, Report of Portuguese Commission for Cancer Research; Ztschr.f. Krebsf., 1908-09, vii, 180. Results of cancer census in Portugal; Ztschr.f. Krebsf., 1908-09, vii, 297. *Newsholme, Arthur, Observations on can- cer {in The elements of vital statistics, London, 1899, 3d edit., pp. 179, 241, 248). *New York State Pathological Laboratory; Annual reports, 1st to 11th, 1899-1911. State Institute for Study of Malignant Disease; 2d and 3d annual reports, Albany, 1913. 1914. *NichoIson, G. W., Observations on kidney tumors; Guy's Hosp. Rpts., London, 1909, series iii, vol. xlviii. *NichoIson, Percival, Blood pressure in general practice; Philadelphia and London, 1913. Nobiling, Herman, Statistics of post- mortem studies of cancer in City Hospital of Munich; Ztschr.f. Krebsf., 1910-11, X, 286. *v. Noorden, Carl, Metabolism and practi- cal medicine, London, 1907, 3 vols. Norris, C. C, Primary carcinoma of vermi- form appendix; Med. Bull., University of Pennsylvania, 1903, xvi, 334. Oertel, Horst, Letter on "menace of can- cer" and American vital statistics; Lancet, Apr. 18, 1914. Oestreicher, Karl, Diabetes and cancer; Prager Med. Wochschr., 1903, No. 24. Ohls, Henry G., Cancer death rate increase in Chicago, 111.; iV/ed. Jowr., Julv, 1915. Oliver, Sir Thomas, Some industrial ac- cidents and diseases; Lancet, June 7, 1913. Radium and its efficacy in cancer; Lancet, Feb. 6, 1915, Tar and asphalt workers' epithelioma and chimney-sweeps' ca.ncer; Brit. Aled. Jour., Aug. 22, 1908. Ordway, Thomas, on the use of radium in cancer and allied conditions, as ob- served at the Huntington Hospital; Symposium on cancer of certain pelvic organs, Proc. of Mass. Med. Soc, Bos- ton, 1914. Orth, Prof., Autopsy statistics of cancer; Berliner klin. Wochschr., Mar. 29, 1909. Paine, A., and Nicholson, G. W., Surgical interference in cancer; Brit. Med. Jour., July 22, 1911. *Palmer, F. W. M., Carcinoma and gastric hydrochloric acid; Guy's Hosp. Rpts., London, 1906, series iii, xlv, 181. Park, Roswell, Nature of the cancerous process; Jotir. Am. Med. Assn., Sept. 14, 1901. Campaign against cancer; Am. Review of Reviews, Dec, 1912. *Parkes, Louis C, Observations on the in- crease in cancer mortality in England and Wales; Jour. Roy. San. Inst., Aug., 1912 (in Transactions, London, 1913, vol. xxxiii). Patent medicines, with observations on cancer in report from select committee of House of Commons; London, 1914. Paterson, Herbert J., Early diagnosis and treatment of cancer of the stomach; Brit. Med. Jour., Oct. 1, 1910. *Payne, J. F., Address on the increase of cancer, with observations on the results of investigation by King and News- holme^ Hunterian Soc. Trans., session 1898-99, London, 1899. *Pearson, John, Practical observations on cancerous complaints: with an ac- count of some diseases which have been confounded with the cancer; London, 1793. *Pembrey, M. S., and Ritchie, James, Text-book of general pathology; New York, 1913. Percy, J. F., A study of heat in cancer; Jour. Am. Med. Assn., May 23, 1914. *Perry, Sir Cooper, and Lauriston, E. Shaw, Statistics of mahgnant disease of the stomach; Guy's Hosp. Rpts., London, 1904, series iii, Iviii, 121. Phelps, Edward Bunnell, Essay on the mortality from alcohol, with observa- tions on cancer; Am. Undenvriter, Sept., 1911, New York. Philipp, Paul Wolfgang, Cancer in child- hood; Ztschr.f. Krebsf., 1907, v. 326. Pinch, A. E. Hay ward. Report of work carried out at Radium Institute, Lon- don, in 1912; Brit. Med. Jour., Jan. 25, 1913. Report of work carried out at Radium Institute, London, in 1913; Lancet, May 23, 1914. 797 BIBLIOGRAPHY Report of work carried out at Radium Institute, London, in 1914; Brit. Med. Jour., Feb. 27, 1915, pp. 367-372. Poppelmann, T^"althe^, Cancer and water; Ztschr.f. Krehsf., 1906, iv. 39. Powers, Chas. A., Early diagnosis in carcinoma; Jour. Am. Med. Assn., Sept. 14, 1901. Power, D'Arcy, Contribution to the dis- tribution of cancer; Practitioner, May, 1903. Prevention of cancer; Jour. Trop. Med. and Hyg., Aug. 1, 1912. Prevention of cancer series; special publi- cations, 1st to 7th; Council on Health and Public Instruction, Am. Med. Assn., Chicago, 1914-15. *Prinzing, F., Article on cancer statistics (in Grotjahn-Kaup Handworterbuch der Sozialen Hvgiene, Leipzig, 1912, i, 678). Mortality from cancer in Wiirttemberg; Wiirt. Med. Korrespondenzhlatt, 1903; also Ztschr.f. Krebsf., 1903-04, i, 146. Obser^'ations on a region of high cancer mortaUty; Ztschr. f. Krehsf., 1907, v, 224. Problem of the gasworks pitch industries and cancer; Report of John Howard McFadden Researches, London, 1913. Pryor, W. R., Operative treatment of can- cer of the uterus; Jour. Am. Med. Assn., Sept. 29, 1900. *Purdy, C. W., Practical urinalysis and urinary diagnosis; Philadelphia, 1905, 6th edit. *Rabagliati, A., Obser^-ations on cancer (in his Air, food and exercise, Xew York, 1904, 3d edit., xi, 381-434). Radestock, George, Statistics of cancer in Saxony; Ztschr. K. Sachs., Statistis-chen Landesamtes, Dresden, 51 Jahrg, 1905. Radium, hearing on, before Committee on Mines and Mining, House of Repre- sentatives, 63d Congress, 2d session, Jan., 1914; ^Yashington, 1914. , report on, before Committee on Mines and Mining, House of Rep- resentatives, 63d Congress, 2d session, Feb. 3, 1914; Washington, 1914. and cancer. Scientific American, and radio-therapeutics, discus- sion. Eighty-first annual meeting Brit. Med. Assn.; Brit. Med, J our., Oct. 11, 1913. therapy; editorial, Brit. Med. Jour., Feb. 27, 1915, p. 381. treatment and cancer; editorial. Lancet, May 23, 1914. in treatment of cancer; editorial. Aug. 1. 1914. Med. Rec., July 11, 1914. Rahts, — ., Observations on cancer in German mortahty statistics; Ztschr. f. Krebsf., 1903-04, i, 145. *Ramazzini, Bern., Treatise on diseases of tradesmen; London, 1705. Randle, John, Cancer among African Creoles; Brit. Med. Jour., Oct. 15, 1910. Renner, W., Obser^'ations on spread of cancer among descendants of the liberated Africans of Sierra Leone; Brit. Med. Jour., Sept. 3, 1910. Observations on cancer among the Creoles of Sierra Leone; Brit. Med. Jour., Jan. 14, 1911. Report on cancer in Iceland and Faroe Islands; Ztschr.f. Krebsf., 1913, xiii, 63. Results of cancer research in Japan; Gann., Jahrgang i. Heft ii, Tokio, 1907. Reutter, — ., Some rare cases of cancer; Inaug. Diss., Lausanne, 1902, Ztschr. f. Krebsf., 1903-04, i, 270. *Richards, Owen, Growths of the kidney and adrenals; Guys Hosp. Rpts., Lon- don, 1905, series iii, vol. xhv. Rodman, W. L., Article on cancer; Jour. Am. Med. Assn., Sept. 30, 1905. Cancer and precancerous conditions; Annals of Surgery, Jan., 1914, Cancer of the breast; Xo. 5, Prevention of cancer series, Council on Health and Public Instruction, Am. Med. Assn., Chicago, 1915. Obser\-ations on cancer of the breast; Jour. Am. Med. Assn., Feb. 27, 1915. Pylorectomy and partial gastrectomy or excision of the ulcer bearing area in the treatment of gastric ulcer; Surg. Gyn. and Obst., Jan. 1915. Roffo, A. H., Experimental cancer; Buenos Aires, 1914, Lancet, Oct. 31, 1914. Rohde, — ., Cancer in youth; Inaug. Diss., Greifswald, 1904, Ztschr. f. Krebsf., 1905, iii, 158. 798 BIBLIOGRAPHY Rohdenburg, George L., Effects of chronic irritation on tissues; Report of George Crocker Spec. Res. Fund, 1913, iii, 75. Romer, Dr., Cancer fear or worry; Ztschr.f. Krebsf., 1906, iv, 75. *Roncali, D. B., Significance of pathogenic blastomycetes in the etiology of carcinoma; Virchow's Arch., 1914, ccxvi. 141, etseq. *Ross, F. W. F., Cancer — the problem of its genesis and treatment; London, 1912. Rous, Peyton, Rate of tumor growth in underfed hosts; Proc. of Soc.for Experi. Biol, and Med., May 17, 1911. Influence of diet on transplanted and spontaneous mouse tumors; Jour. Experi. Med., 1914, vol. xx. No. 5. Rovighi, — ., Malaria and cancer; Ztschr.f. Krebsf., 1903-04, i, 165. Concerning cancer and malaria; Ztschr. f. Krebsf., 1905, iii, 604. Rovsing, T., Dangers from radium treat- ment of cancer; Hospitalstidende, Copenhagen, July 8, 1914, vol. Ixii, No. 27. Rugh, J. T., A case of concurrent sarcoma and hip-joint disease; Am. Jour. Med. Sciences, July, 1895. Russell, Rollo, Observations on cancer prevalence. *Preventable cancer, a statistical re- search; London, 1912. Ryall, Charles, Lecture on cancer of the uterus; Lancet, Aug. 8, 1914. Saalfeld, Edmund, Diabetes and skin disease; Deutsche Med. Wochschr. Sachs, E., Die Wintersche "Bekampfung des Gebarmutterkrebses"; reprinted from Ztschr.f. Krebsf., Berlin, 1910, ix. *SaIeeby, C. W., The conquest of cancer; New York, 1907. Sanes, K. I., Statistics of cancer in the female; Med. Rec, Oct. 22, 1910. *Sargant, W. L., On the vital statistics of Birmingham and seven other large towns; Jour. Roy. Stat. Soc, London, 1866, part 1, xxix. *Savidge, Eugene Coleman, The problem of cancer (preliminary author's proof) ; New York, 1915. *Saundby, Robert, Old age — its care and treatment in health and disease; Lon- don, 1913. *SaviIl, Thomas Dixon, A system of clinical medicine; New York, 1912, 3d edit. Scherk, K., Suggestion for the study of cancer etiology; Ztschr. f. Krebsf., 1903-04, i, 239. *Schmidt, Rudolph, Diagnosis of malignant tumors of the abdominal viscera; New York, 1913. *Schmiegelow, E., Results of operation for intrinsic cancer of the larynx; Lancet, Aug. 1, 1914. Senn, N., Present status of the carcinoma question; Jour. Am. Med. Assn., Sept. 28, 1901. A plea for the international study of carcinoma; Jour. Am. Med. Assn., Apr. 28, 1906. Sequeira, J. H., Treatment of malignant disease of the skin; Brit. Med. Jour., Feb. 27, 1915, pp. 365-366. *Sharp, Samuel, A treatise on the oper- ations of surgery, and an introduction on the nature and treatment of wounds, abscesses and ulcers; London, 1758, 7th edit. Shaw, John, Cancer: some of its problems and their solution; Neuchatel, 1913. *Shaw-Mackenzie, J. A., The nature and treatment of cancer; New York, 1906, 4th edit. Shrady, G. F., Some observations on cancer of the breast; Med. Rec, Nov. 12, 1892. Sierra Leone, Annual report of medical department, with observations on cancer at Lagos; 1910. Simmonds, M., Primary causes of death of cancer patients; Ztschr. f. Krebsf., 1903-04, i, 315. Sittenfield, M. J., Recent advances in the study of the pathogenesis of cancer; Med. Rec, Apr. 25, 1914. Skerrett, F. B., and others, On the nature and origin of cancer; Brit. Med. Jour., Dec. 16, 1911. Slye, Maud, Incidence and inheritability of spontaneous cancer in mice; Ztschr. f. Krebsf., 1913, xiii, 500. *Incidence and inheritability of spontane- ous tumors in mice; 2d report. Jour. Med. Res., July, 1914, vol. xxx. No. 3. *Primary spontaneous tumors of the lungs in mice; 4th report. Jour. Med. Res., July, 1914. 799 BIBLIOGRAPHY Smith, In'in F., Cancer in plants; Proc. of 17th International Congress of Medi- cine, London, 1913. Smithies, Frank, Significance of gastric nicer with reference to gastric cancer; Jour. Am. Med. Assn., Nov. 15, 1913. Cancer of the stomach; Philadelphia, 1915. Diagnostic worth of laboratory data in gastric cancer; Illinois Med. Jour., Feb., 1915, vol. xxvii. No. 2. Observations on gastric cancer in the young; Jour. Am. Med. Assn., Nov. 21, 1914. Symptom.s and signs of gastric cancer; Jour. Am. Med. Assn., Feb. 20, 1915, p. 643. Smoke Investigation, Report on the in- fluence of smoke on health; Bull. No. 9, Mellon Institute of Industrial Research and School of Specific In- dustries, University of Pittsburgh, Pittsburgh, 1914. Soegaard, Munch., Die Krebsformen Nor- wegen (Forms of cancer frequency in Norway); Ztschr.f. Krebsf., 1913, xiii, 89. Spencer, W. G., Discussion on the etiology and treatment of carcinoma of the tongue; Brit. Med. Jour., Sept. 12, 1914. Spiritual healing and cancer; editorial, Brit. Med. Jour., May 22, 1909. Statistics of cancer in INIontevideo (Uru- guay); Ztschr.f. Krebsf., 1905, iii, 308. of cancer in Netherlands, 1901-09; The Hague, 1911, of cancer in Santiago de Chile; Ztschr.f. Krebsf., 1905, iii, 311. *Stevens, T. G., Statistics of radical opera- tions for uterine cancer; Guy's Hosp. Rpts., London, 1901, series iii, vol. xl. Stewart, M. J., Observations on myeloid sarcoma; Lancet, Nov. 28, 1914. Sticker, Anton, Endemic cancer; Ztschr. f. Krebsf., 1907, v, 215. Storck, Dr., Essay on the medicinal nature of hemlock, used in the cure of cancers, schirrous and oedematous tumors, malignant and fistulous ulcers, etc.; London, 1760. Strandgaard, — ., Erj^sipelas and cancer; Ugeskriftfor Laeger, Copenhagen, Sept. 24, 1914, vol. Ixxvi, No. 39. Stratz, C. H., Early recognition of cancer of the uterus; Ztschr. f. Krebsf., 1905, iii, 192. Stuart, C. A. V., Observations on cancer in the Netherlands; Nederlandsch Tijd- schrift voor Geneeskunde, Amsterdam, May 2, 1914, No. 18. Sweet, J. E., Corson-White, Ellen P., and Saxon, G. J., Relation of diets to the transmissible tumors of rats and mice; Jour. Biol. Chem., July, 1913. Symposium on cancer. Abstract of papers presented at Clinical Congress of Surgeons of North America, Nov. 13, 1913 (includes papers by Thos, J. Cullen, Samuel Hopkins Adams, Edward Reynolds, F. R. Green, Frederick L. Hoffman, C. J. Gauss, Joseph C. Bloodgood); Chicago Med. Rec., Nov., 1913. on cancer of certain pelvic organs; Annual meeting of Massachu- setts Med. Soc, Section of Surgery, Boston, June 9, 1914. on end-results of operations for cancer of breast; Annual meeting of Am. Surg. Assn., Washington, 1907; Jour. Am. Med. Assn., June 22, 1907. Syms, Parker, The prevention and cure of cancer; Med. Rec, May 17, 1913. Syphilis and cancer; Jour. Am. Med. Assn., Aug. 29, 1905. Taussig, F. J., Best methods of educating American women concerning cancer; Sur., Gyn. and Obst., Nov., 1913. Cancer of the uterus; Am, Jour. Nurs- ing, Mar., 1915. *Taylor, Frederick, Some cases of malig- nant disease of the chest and abdomen ; Guy's Hosp. Rpts., London, 1893, series iii, xxxiv, 123. *Taylor, Howard Canning, Cancer, its study and prevention; Philadelphia and New York, 1915. *Teece, Richard, Observations on the in- crease of cancer; Quarterly publica- tions of Am. Stat. Assn., Jour. Inst, of Actuaries, July, 1901. *Review of paper on the increase of cancer; Quarterly publications of Am. Stat. Assn., Dec, 1901. Templeman, Chas., Observations on cancer mortality; Brit. Med. Jour., Feb. 14, 1903. 800 BIBLIOGRAPHY ♦Thackrah, C. T., Effects of arts, trades and professions, etc., on health and longevity; London, 1832, p. 122. Theilhaber, A., Necessity for modifying the blood in treatment of cancer; Wiener klin. Wochschr., Mar. 5, 1914, vol. XXX vii. No. 9. *Thompson, W. G., Occupational diseases, their causation, symptoms, treatment and prevention; New York and Lon- don, 1914. Thomson, Alexis, Conditions liable to be mistaken for cancer of the stomach; Brit. Med. Jour., Oct. 1, 1910. Thomson, Sir St. Clair, Intrinsic cancer of the larynx; Jour. Am. Med. Assn., Sept. 19, 1914. Treatment of cancer; editorial, Brit. Med. Jour., Mar. 6, 1909. Trotter, Wilfred, Prognosis in cancer of the tongue; Lancet, Oct. 24, 1914. Turnbull, Arthur, On the genesis of cancer; Brit. Med. Jour., Oct. 11, 1913. Turner, Dawson, Radium treatment at Royal Infirmary, Edinburgh; Brit. Med. Jour., Feb. 27, 1915, pp. 373-375. Tyzzer, E. E., Relation of heredity to can- cer; Jour. Am. Med. Assn., Oct. 29, 1910. Unglert, Dr., Geographical distribution of cancer; Ztschr. f. Krebsf., 1908-09, vii, 215. Vaughan, J. W., Some modem ideas of cancer; Jour. Am. Med. Assn., May 7, 1910. *Verworn, Max, Irritability; New Haven, 1913, p. 21. Virchow, Rudolf, Lecture on sarcoma (translation by James Tyson); Med. Rec, 1869. Wainwright, Jonathan M., The reduction of cancer mortality; N. V. Med. Jour., Dec. 9, 1911. *Walshe, Walter Hayle, The anatomy, physiology, pathology and treatment of cancer, with additions by J. Mason Warren; Boston, 1844. Watkins-Pitchford, Wilfred, Light, pig- mentation and new growth; Brit. Med. Jour., Aug. 21, 1909. *Weil, Richard, Biochemical investigation of malignant tumors; Report of Collis P. Huntington Fund for Can. Res., New York, 1912, vol. iii. The autolysin treatment of cancer; Jour. Am. Med. Assn., Nov. 6, 1915. Weinberg, W., Critical remarks on marital cancer occurrence; Ztschr. /. Krebsf., 1906, iv, 83. The problems of cancer statistics; Ztschr. f. Krebsf., 1910-11, x, 280. Statistics of cancer a deux; Ztschr. f. Krebsf., 1913, xiii, 441. and Caspar, Statistics of malig- nant growths in Stuttgart; Ztschr f. Krebsf. (two articles), 1904, ii, 195, and 1906, iv, 18. *Weinstein, J. W., and others. Methods for the diagnosis of cancer; Report of George Crocker Spec. Res. Fund, 1915, iii, 160, et seq. Wells, H. G., Resistance of the human body to cancer; Jour. Am. Med. Assn., May 29, 1909. *Wemer, R., Results and problems of cancer census of Baden; in Institute f. Krebsf., in Heidelberg, Tubingen, 1910. *Statistical investigations into the oc- currence of cancer in Baden and their value in etiological studies; Tubingen, 1910. *Westergaard, Harald, Die Lehre von der Mortalitat und Morbilitat; Jena, 1901. *What to observe at the bedside and after death in medical cases; published mider the authority of the London Med.Soc. of Obser., Philadelphia, 1853. *WheeIer, F. J., Observations on primary carcinoma of the liver; Guy's Hosp. R-pts., London, 1909, series iii, vol. xlviai. *White, Charles Powell, The pathology of growth — tumors; New York, 1913. White, Geo. D., Is cancer contagious.' Med.Rec.,¥e^.V"^ V ■