■REM W (Eolumbta Hmopratty \^o*i in % (Hug of Neut fork k.L,„u Digitized by the Internet Archive in 2010 with funding from Open Knowledge Commons (for the Medical Heritage Library project) http://www.archive.org/details/manualofsurgeryfOOrose A MANUAL OF SURGERY jfor StuDcnts ant) fcractitionets MANUAL OF SURGERY jfor Stufccnts anfc practitioners BY WILLIAM ROSE, M.B., B.S., Lond., F.R.C.S., Professor of Clinical Surgery in King's Collf.ge, London, and Senior Surgeon to King's College Hospital, etc. ALBERT CARLESS, M.S. Lond., F.R.C.S., Surgeon to King's College Hospital, and Teacher of Operative Surgery in King's College, London; Examiner in Surgery to Glasgow University, etc. FIFTH EDITION NEW YORK WILLIAM WOOD & COMPANY MDCCCCH, TO LORD LISTER, ll.d., f.r.s., President of the Royal Society, THE FATHER OF ANTISEPTIC SURGERY, THIS WORK IS, WITH PERMISSION, gefoicatei) bn the Jluthors, IN GRATEFUL ACKNOWLEDGMENT OF THE MANY ADVANTAGES THEY HAVE DERIVED WHILST ASSOCIATED WITH HIM IN HIS WORK AT KING'S COLLEGE HOSPITAL. PREFACE TO FIFTH EDITION. In issuing a fifth edition of this work within twelve months of the fourth we would note that considerable modifications have been made in order to bring it up to date and to fit it more satisfac- torily to modern requirements. It seemed undesirable to per- petuate any longer the idea that the first and most important element in surgical practice is a knowledge of inflammation and its treatment, and hence this subject has been removed from its original position and has been located to one secondary to that occupied by Bacteriology and the principles of Antiseptic and Aseptic Surgery. Sundry other changes will be found which will lead to a more harmonious pathological and clinical picture than was previously presented. In conclusion we must acknowledge our indebtedness to many friends who have made valuable and useful suggestions ; to Professor R. T. Hewlett, who has run over the sheets of the first chapter and indicated various modifications to us which make it more authoritative ; and to Mr. T. P. Legg, our Surgical Registrar at King's College Hospital, who has undertaken at very short notice the arduous task of revising the Index. August, 1902. PREFACE TO FIRST EDITION. In preparing this Manual of Surgery for the profession, we have endeavoured to meet what we think is at the present time a genuine need. The many large and valuable text-books and works of reference already in existence are almost more than the ordinary student can master during the time at his disposal. It has therefore been our aim to present the facts of surgical science in a concise and succinct form, so as to satisfy the needs of the student, even of those who are preparing for the higher examina- tions. At the same time, the requirements of the general prac- titioner have not been overlooked, for we have taken care to discuss in detail those conditions which are most likely to be met with in ordinary practice. The main difficulty has been to com- press into a small space the ever-increasing amount of material available, so that we have only been able to sketch in out- line much that could have been elaborately described did the size of the book permit. For the same reason, historical and bibliographical references have to a large extent been omitted, whilst diseases of special regions — such as the eye, ear, and female genital organs — are also practically excluded, except in so far as they encroach on the domains of general surgery. The progress of bacteriology and the influence of antisepsis have so transformed the characters and extended the scope of surgical work that many of the traditions and theories of the past have had to be discarded, PREFACE TO FIRST EDITION although at the same time we have endeavoured to preserve and respect that which has been shown to be good and useful in the laborious researches and accumulated experiences of bygone generations. In conclusion, our best thanks are due to Dr. St. Clair Thom- son, who has kindly looked through the proofs of the sections devoted to the nose and ear ; to Dr. Silk, who has fulfilled a similar office in reference to the chapter on anaesthetics ; to Mr. William Turner for preparing the index ; and to Dr. Arthur Griffiths, late of the Bristol General Hospital, who has drawn several of the pictures, and given other valuable assistance. Many of the illustrations have been specially prepared for this work, but we have also to acknowledge the loan of blocks from Messrs. Veit and Co., of Leipzig ; from Messrs. Cassell and Co., J. and A. Churchill, Longmans and Co. ; and from the editors of the Lancet for the loan of Fig. 287 [296]. The various sources from which these are derived are acknowledged throughout the book. Illustrations of instruments are mainly derived from Messrs. Down Brothers, who have kindly placed them at our disposal. W. ROSE, 17, Harley Street, W. A. CARLESS, 10, Welbeck Street, W. London, May 1, 1898. CONTENTS CHAPTER PAGE I. SURGICAL BACTERIOLOGY SEPSIS AND INFECTION ANTISEPSIS AND ASEPSIS - - - - I II. INFLAMMATION - - - - ' 2 3 III. SUPPURATION AND ABSCESS - - - " 4 1 IV. ULCERATION - - - - - 58 V. GANGRENE - - - - - 67 VI. INFECTIVE DISEASES - - - - 90 VII. TUMOURS AND CYSTS - - 150 VIII. WOUNDS ...--- igo IX. HEMORRHAGE - - - - -...." 222 X. INJURIES AND DISEASES OF ARTERIES ANEURISM LIGATURE OF ARTERIES ... - 246 XI. SURGERY OF THE VEINS .... 298 XII. DISEASES OF THE LYMPHATICS - - 312 XIII. AFFECTIONS OF NERVES .... 326 XIV. SURGICAL DISEASES OF THE SKIN AND OF THE CUTANEOUS APPENDAGES - - - " 35 1 XV. AFFECTIONS OF MUSCLES, TENDONS, AND BURSE - 363 XVI. DEFORMITIES ------ 378 XVII. INJURIES OF BONES FRACTURES - - - 417 XVIII. DISEASES OF BONE ----- 495 XIX. INJURIES OF JOINTS DISLOCATIONS - - - 539 XX. DISEASES OF JOINTS ----- 573 XXI. INJURIES OF THE SPINE ... - 628 CONTENTS CHAPTER XXII. DISEASES OF THE SPINE - 646 XXIII. HEAD INJURIES ..... 667 XXIV. DISEASES OF THE SCALP, CRANIUM, AND CRANIAL CONTENTS ..... 705 XXV. AFFECTIONS OF THE LIPS AND JAWS - - 723 XXVI, AFFECTIONS OF THE NOSE AND NASO-PHARYNX - 753 XXVII. AFFECTIONS OF THE MOUTH, THROAT, AND OESO- PHAGUS --..-. 772 XXVIII. AFFECTIONS OF THE EAR .... 813 XXIX. SURGERY OF THE NECK .... 822 XXX. SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST 838 XXXI. DISEASES OF THE BREAST - - - - 866 XXXII. ABDOMINAL SURGERY .... 89I XXXIII. HERNIA ...... 970 XXXIV. INTESTINAL OBSTRUCTION - - - - IOOg XXXV. AFFECTIONS OF THE RECTUM AND ANUS - * - IO25 XXXVI. SURGICAL AFFECTIONS OF THE KIDNEYS - - IO5O XXXVII. SURGERY OF THE BLADDER AND PROSTATE - IO72 XXXVIII. AFFECTIONS OF THE URETHRA AND PENIS - - III7 XXXIX. AFFECTIONS OF THE TESTIS, CORD, SCROTUM, AND SEMINAL VESICLES - - II43 XL. AMPUTATIONS - - - II65 XLI. ANAESTHESIA - - - I184 INDEX - - I 192 LIST OF PLATES. PLATE PAGE I. Various Types of Bacteria - - To face i II. Fig. i. — Early Stage of Abscess Formation - 44 Fig. 2. — Section of Abscess Wall Eight Days Old ,, 44 III. Fig. 1. — Military Tubercle with Giant Cell (Highly Magnified) - - To face 142 Fig. 2. — Tuberculous Abscess from a Suppurating Lym- phatic Gland (Low Power) - - - To face 142 IV. Exostosis of the Radius - - - ,, 165 V. Fig. 1. — Hard Glandular Carcinoma, with abundance of firm Fibro-Cicatricial Stroma (Scirrhous Mamm.e) To face 180 Fig. 2. — Granulation Tissue from a Healing Wound ,, 180 VI. Skiagram of Hand, with Needle embedded in the Palm, close to the Carpus - - - - To face 200 VII. Splinter of Glass in Hand, close to Metacarpal Bone, of the Index Finger - - To follow Plate VI. VIII. Fig. 1. — Section of a Wound Healed by First Intention Ten Days after its Infliction - - To face 214 Fig. 2. — Scar from a Recently Healed Superficial Wound (Low Power) - - To face 214 IX. Skiagram of Double Coxa Vara - - - 394 X. Oblique Fracture of Tibia, showing the Ends of the Fragments shaped en bee de flute - To face 420 XL Impacted Fracture of Anatomical Neck of Humerus ,, 450 XII. Fracture of Surgical Neck of Humerus To follow Plate XI. XIII. Separation of the Lower Epiphysis of the Humerus, with Displacement Outwards, in a Young Person, a little over the Age of Puberty - - To face 458 XIV. Fracture of Olecranon before Operation - ,, 460 XV. Fracture of Olecranon Two Weeks after Operation To follow Plate XIV. LIST OF PLATES PLATE I'AGE XVI. Fracture of Olecranon Six Weeks after Operation To follow Plate XV. XVII. Fracture of Shaft of the Radius — Antero-posterior View - - To face 462 XVIII. The same Fracture seen from the Side To follow Plate XVII. XIX. Colles's Fracture : a Simple Case, without much Lateral Displacement of Hand - - To face 462 XX. Colles's Fracture : a Bad Case, with the Styloid Process of the Ulna torn off' and much Outward Displacement of Hand - - To follow Plate XIX. XXI. Fracture of both Bones of the Forearm, with Dis- placement Outwards - To face 466 XXII. Fracture of both Bones of the Leg, seen from in Front - - - -To face 488 XXIII. The same Fracture as in Plate XXII., seen from the Inner Side - - To follow Plate XXII. XXIV. Bad Pott's Fracture, with well-marked Displacement Outwards of the Foot, as well as of the Lower Fragment of the Fibula and the Internal Malleolus. (Skiagram taken from in Front) - - To face 490 XXV. Tuberculous Disease of Radius - - ,, 514 XXVI. Double Congenital Dislocation of the Hip - ,, 542 XXVII. Dislocation of Radius Forwards, and Fracture of Upper Third of Ulna - - To face 558 XXVIII. Tuberculous Disease of Knee-joint, showing Invasion of Patella - - - - To face 588 XXIX. Skiagram of Pelvis, showing Tuberculous Disease of Right Hip-joint - - To face 616 N.B. — All the X-ray pictures in this work have been taken by Messrs. Allen and Hanbury, 48, Wigmore Street, W., who have kindly placed the negatives at our disposal. ERRATUM. On page 160, line 7, for ' p. 145,' read ' p. 181. PLATE I. ., ^ t««, -*• Fig. i. Fig. 2. Fig. 3. Fig. 4. Jo face ./. 1. ] Fig. 5. Fig. 6. A MANUAL OF SURGERY. CHAPTER I. SURGICAL BACTERIOLOGY — SEPSIS AND INFECTION — ANTISEPSIS AND ASEPSIS. Bacteriology, or the science devoted to the study of bacteria, must necessarily be the basis of all scientific surgery, which apart from such knowledge degenerates into little more than a technical art. It is the surgeon's duty to understand the life-history and methods of activity of bacteria, so that he may be able to prevent their access to wounds, or, if they have gained a foothold in the system, be able to combat them. To this latter end he must call to his aid all the powers of resistance latent in the economy, and should be able to add to these by the introduction of suitable protective substances developed artificially. Of course, it is not altogether desirable that an active operating surgeon should be constantly working in the laboratory with virulent germs, but he must have acquired a sound knowledge of bacteriological technique, and be fully capable of appreciating the researches and investigations made by others. Bacteria, or schizomycetes, form a very important and numerous class of minute vegetable organisms, which are in the present day looked upon as the essential cause of putrefaction and of most of the inflammatory diseases. They consist of minute masses of protoplasm enclosed in a cell wall, and with sometimes a gelatinous capsule or envelope, which may suffice to hold together two or four elements or even larger colonies. They vary in shape, size, and arrangement, and from a mor- phological standpoint have been classified under the following headings : i. Micrococci, or Cocci, are roundish or oval cells, multiplying rapidly by a process of fission (i.e., division into equal parts). They may remain isolated, but, as a rule, are collected into certain definite formations, and in consequence are termed staphy- i A MANUAL OF SURGERY lococci, or cluster-cocci (Fig. 3), when they are grouped like a bunch of grapes, usually occurring thus in localized inflamma- tions ; streptococci, or chain-cocci (Plate I., Fig. 1), when they develop in chains or strings, the characteristic of spreading inflammations ; diplococci, when they occur in pairs — e.g., the gonococcus or pneumococcus, met with in gonorrhoea and pneu- monia respectively. When they are grouped into packets of four or eight individuals, they are usually termed sarcina (Plate I., Fig. 2). Occasionally any of the above may occur in masses or colonies, slimy or gelatinous in character (zooglcea). 2. Bacilli, or rod-shaped bacteria, are found in the form either of long or short filaments, made up of an aggregation of individual rods united end to end; or they may become curved, and so form spiral rods, which may break up into the so-called comma-shaped bacilli ; or they may persist in the body of their host as isolated rods, free in the blood or lymph, or within the substance of the cells invaded. They multiply by fission, or by the formation of spores in their interior. These latter are much more resistant and less easily destroyed than the parent rods. The spore may develop in the centre of the bacillus, as in Bac. anthracis, or at one end, as in the so-called drumstick-shaped Bac. tctani. 3. Spirilla (Plate I., Fig. 4) form corkscrew - like threads, possessing active power of movement. They are of no surgical interest, and in human pathology only occur in a few conditions, such as remittent fever. It will here only be possible to sketch in outline a few general facts as to the life-history and mode of activity of these organisms. Methods of Examination. — These are in the main threefold : 1. Microscopic Examination. — High powers of the microscope (e.g., -,V in- oil immersion) are needed for this work, and even with them it is often difficult to determine the characters of any particular form of microbe under examination. Minute differences in the size and shape may assist, and the relative arrange- ment in chains, clusters, etc. ; whilst the effect of different staining reagents is also important. Into the various methods of demonstrating and staining bacteria it is impossible to enter. 2. Cultivation in or on various nutrient media is of the greatest assistance in determining the exact nature of any special organism under examination. For this purpose the cut surface of a raw potato after sterilization of the exterior suits excellently in many cases. Fluids, such as meat infusion, milk, or fresh blood serum, are not very satisfactory, but similar materials, solidified by the addition of gelatine or agar-agar, and either placed in test-tubes or on plates, or meat infusion mixed with peptone, are the most suitable nutrient bases. In testing the life-history of any microbe, it is important to note whether or not it will develop in contact with the air. This may be accomplished by the use of nutrient gelatine poured into test-tubes, some of which are allowed to cool in the vertical position, and others on the slant. The former are inoculated by puncturing the horizontal surface with an infected platinum wire (stab culture), the latter by streaking it along the oblique surface (streak culture). 3. Inoculation experiments are really the most reliable means of examining into the relations of micro-organisms to any particular affection ; but it must be clearly recognised that animals are not necessarily affected in the same way SURGICAL BACTERIOLOGY as man. Koch has insisted that the four following essentials must be fulfilled in order to prove the infective character of any particular disease : (i.) The organism must be present in every case, either in the tissues or in the blood, (ii.) It must be possible to cultivate it for many generations apart from the body, (iii.) Its inoculation into a suitable animal must be followed by the appear- ance of the specific disease ; and (iv.) The organism must be found in the tissues or blood of the animal infected in this manner. Habitat. — Bacteria are almost universal in their distribution. Earth, air, and water are full of them, and especially so in populous neighbourhoods. The greater the number of the inhabitants, the larger the number of organisms in the air. In isolated, and especially mountainous, districts there are com- paratively few, whilst in the air of a crowded hospital ward swarms of them are present, and these often of a most dangerous type. Food-stuffs and fluids, such as water and milk, are fre-. quently contaminated, and by these means disease is often intro- duced into the system. The surface of the body is impregnated with bacteria, which extend to a depth greater than can be affected by mere domestic cleanliness, whilst the intestinal tract teems with them from mouth to anus. It appears that whilst the external auditory meatus and inferior meatus of the nose are occupied by bacteria, the upper meati of the nose are sterile, as also the upper part of the virgin vagina and the deeper portion of the (uncontaminated) male urethra. The gall-bladder, as well as the biliary and pancreatic ducts, is also normally free from germs, whilst in a healthy individual the solid organs, the blood, and lymph are also practically sterile. Any condition of general weakness facilitates the entrance of germs into the system, or, perhaps one should say, diminishes the resistance of the body to their presence and activity, and hence lays the individual open to the occurrence of diverse infective diseases. Mobility. — The cocci are as a group incapable of active locomo- tion, although they manifest, in common with all minute non- living particles, ' Brownian ' movements. Most bacilli and spirilla have in addition the power of moving from place to place, accomplished by means of flagella, which develop at one or both ends as single filaments or in bunches all over the organism. These can be readily demonstrated in the Bac. typhosus (Plate I., Fig- 3). Multiplication. — The power of multiplying possessed by bacteria is enormous, though not unlimited. Two methods have been mentioned above — viz., fission and the formation of endospores. Spore formation is not known to occur in the. cocci or sarcinae, and, although common among the bacilli, is not invariable ; thus the Bac. typhosus and the Bac. diphtheria are asporogenous. Only one spore forms in each bacillus, and, as already stated, its i — 2 A MANUAL OF SURGERY position varies in different species. The conditions favourable to the development of spores have not yet been fully ascertained, but in most varieties a free supply of oxygen is required ; it is also a fact that spores rarely form amongst the living tissues of the body. Conditions of Growth. — The activity and development of bacteria are physiological phenomena, carried out in accordance with the general laws governing animal and vegetable life, and requiring certain definite conditions to be present. The pabulum, or food- stuff, differs somewhat with the particular species, but they all require water, oxygen, hydrogen, nitrogen, carbon, and certain inorganic salts ; they usually grow better on highly complicated substances than on more simple materials. Desiccation arrests bacterial growth, although the organisms are not killed thereby. Temperature has also considerable influence upon their develop- ment. Few germs grow well under 20 C, and pathogenic organisms develop best at about 37 to 38 C. Cold checks all growth, but does not kill the germs. Any degree of heat above 57 C, if allowed to act long enough, will suffice to kill most bacteria, but spores require a much higher temperature for their destruction. Light, especially direct sunlight, has a retarding influence on the development of most micro-organisms. The necessity or not for atmospheric air in their development constitutes the basis of the division of microbes into aerobic and anaerobic. When they can grow in, and, indeed, require for their development, the actual presence of free air, they are termed obligate aerobes. If, however, they have the power of acquiring the oxygen they need from the tissues surrounding them, they are then known as facultative anaerobes ; their development is then rather less rapid than when aerobic conditions are present. Obligate anaerobic organisms are those which require an atmosphere around them, from which oxygen is rigidly excluded, and these usually flourish best in nitrogen or hydrogen — e.g., the bacillus of tetanus. It must be remembered, however, that although their power of development is arrested by the presence of oxygen, it is not destroyed ; the restoration of anaerobic conditions will at once restore their vital activities. Results of Growth. — Many different substances result from bacterial growth, both in culture media and in the body, and upon the characters of these depend to a large extent the symptoms of the special diseases. Chief amongst them are the Toxins, which are perhaps more intensely poisonous than anything else known. Many of them are albuminous bodies (possibly albumoses) ; most of them have a ferment-like action ; and not a few are capable of liquefying gelatine or peptonizing proteids. The toxins formed by putrefactive organisms {the ptomaines) are more or less peculiar in that they are alkaloidal in nature — i.e., built up in the like- ness of ammonium hydrate (NH 4 HO) — they unite with acids, SURGICAL BACTERIOLOGY— SEPSIS and can be crystallized. The development of toxins in the body is the all-important cause of the symptoms of disease ; locally, they give rise to various inflammatory phenomena, and by their general absorption produce either pyrexia alone, or peculiar and characteristic manifestations, as in tetanus and diphtheria. Other results of bacterial activity are less important, though some are very obvious, i. Acid substances may be formed ; e.g., the Bac. acidi lactici is the constant cause of the souring of milk. 2. Alkaline products may develop; e.g., the Diplococcus urea trans- forms the urea of urine into carbonate of ammonia. 3. Gases, often of a very penetrating odour, may be produced by others ; e.g., Bac. coli communis, or Bac. cedematis maligni. 4. Various colouring bodies are generated, but this property is mainly limited to the non-pathogenic group. 5. Phosphorescence is also caused by certain bacteria. From their environment in pathological conditions, bacteria are divided into two great classes, according to whether or not they can develop in the living tissues. The pathogenic or parasitic bacteria can do so, producing what are known as infective diseases ; but when an organism can only develop in dead tissues, such as masses of slough, or in exudations of blood, serum, or pus, or in some non-living nutrient material, it is called a non- pathogenic; saprophytic, or carrion microbe, and any inflammatory reaction, local or general, thereby induced is due to the irritating effect of the toxic bodies produced in this way, and not directly to the action of the bacteria. Some of the pathogenic organisms are capable of continuing their development in dead tissues as facultative saprophytes, and this property is one of great danger, in that it permits of extensive diffusion of the virus ; the tetanus, anthrax, and malignant oedema bacilli, as also the pyogenic cocci, are characterized by this property. It is now possible to define the terms ' sepsis ' and ' infection ' as employed in surgical practice. Sepsis. Sepsis is a term, somewhat loosely applied, to indicate that a wound or sore has become infected w 7 ith micro-organisms in such a way as to interfere with healthy reparative action. When it involves an operation wound, it is due to contamination from a dirty state of the skin, impure instruments, ligatures or sutures, unsterilized hands of the surgeon or assistant, a faulty dressing, etc. Sepsis may also develop in connection with any unprotected sore or abrasion, and the offensive odour which accompanies neglected syphilitic or cancerous sores is simply due to this, and is no essential part of the causative affection. The organisms present in septic affections vary considerably, but are of two main types : (a) Various non-pathogenic microbes, A MANUAL OF SURGERY especially the Proteus vulgaris, P. Hausevi, sundry forms of Sarcince, and, under certain circumstances, the Bac. coli communis, and (b) the ordinary pyogenic bacteria, especially the staphylococci and streptococci, which are, of course, pathogenic. The method of action of these organisms is somewhat diverse. (a) The former, or non-pathogenic group, can only develop in dead tissues or fluids, or in passive material such as blood-clot, pus, or serum ; they may occasionally gain an entrance to the general circulation, but are rapidly destroyed, and do no harm. It is obvious, therefore, that a dry wound is less likely to become septic than one in which there is much exudation of blood or serum, so that absolute haemostasis and good drainage are two most important preventive measures. When once admitted to the part, the organisms rapidly multiply, causing putrefaction or other changes in any suitable pabulum present, and thus produce irritating or poisonous chemical substances, upon the action of which the symptoms of sepsis, whether local or general, depend. If a large quantity of putrescible material is present, the wound or part may become very offensive, and a sloughing process may ensue as a result of the irritating local action of the toxins, whilst at the same time general toxic symptoms are manifested, varying in severity with the dose absorbed. (b) The latter group of true pyogenic bacteria are capable of growth in a similar manner, but in addition are able to invade and develop in the tissues of the body (infection), and so may give rise to spreading inflammation, such as erysipelas or cellulitis, and to general infective diseases, such as pyaemia or septicaemia. Into the question of local appearances and treatment it is unnecessary to enter here,' but it is desirable to add a few words as to the general conditions which are associated with a septic wound. They are entirely due to the absorption of the toxins produced in the inflammatory focus, and hence vary considerably in severity with the dose. Thus three varieties have been described : i. When the dose is small, but if it is absorbed regularly and for a long time, a definite diurnal range of temperature follows, known as hectic fever (p. 52). It is always associated with per- sistent and prolonged suppuration. 2. Septic Traumatic Fever is due to the absorption of a some- what larger amount of the poison after an operation or injury, which is followed by septic inflammation. A burn or compound fracture which is not rendered aseptic is always accompanied by fever, ranging from 102 to io4°F. for some days, until the wound is securely sealed off by the development of granulation tissue. When once this has occurred, the fever usually disappears, unless septic material is retained under pressure. The actual phenomena connected with such an attack are in no way peculiar. 3. Acute Saprsemia, or Septic Intoxication, results from the SEPSIS AND INFECTION absorption of a large dose of toxic material. This condition was for long confounded with true infective septicaemia, and even now, though clearly distinguished pathologically, a clinical dis- tinction between the two is not always possible, except by await- ing the result. Sapraemia is essentially a toxaemia, or condition due to chemical poisoning ; the blood is not infective, and the symptoms are directly proportionate to the dose. Any condition in which there is a large mass of putrefying tissue or fluid from which absorption can occur may lead to sapraemia — e.g., a portion of decomposing placenta in the puerperal uterus, the existence of septic pus under pressure in the peritoneal cavity, a joint, or else- where ; or a mass of putrefying blood-clot, say, in the pleural cavity after a penetrating wound. The Symptoms usually commence, two or three days after the cause has come into operation, with a severe rigor, followed by a maintained high temperature, although sometimes it is subnormal in the more serious cases. This is associated with loss of appetite, a dry tongue, a quick pulse, rapidly becoming weak, severe headache, and nocturnal delirium of some intensity. The patient is at first constipated, but vomiting and diarrhoea may ensue from gastro-intestinal irritation, followed by fatal exhaus- tion and collapse, or he may become comatose and unconscious for some time before death, according to whether the toxins act chiefly upon the alimentary system or upon the cerebral centres. Dyspnoea, from pulmonary congestion, and albuminuria, also occur. Should, however, the putrefying mass be removed in time, the fever will cease as by magic, the tongue cleans, the appetite returns, the headache vanishes, and in twenty-four hours the patient feels a different individual. Post-mortem Appearances. — Decomposition is early, rigor mortis feeble, and cadaveric lividity well marked, especially along the lines of the superficial veins and posteriorly. The blood coagulates imperfectly, and is dark and tarry in colour ; if allowed to stand, the serum which separates from the corpuscles is much stained from the breaking up of the red blood-cells which occurs in all septic and infective cases. This condition explains the amount of cadaveric lividity, and also the post-mortem staining of the endocardium and tunica intima of the larger vessels, which is such a marked feature in these cases, and which was formerly supposed to result from a diffuse arteritis. Most of the serous cavities contain a certain amount of blood-stained fluid, and under almost all the serous membranes are well-marked petechia?, especially under the pericardium and pleura. The lungs are deeply congested, particularly at the back, and very cedematous ; the liver, spleen, and kidneys are enlarged, pulpy, soft, and congested, notably the spleen. The epithelium of most of the secreting glands, if examined microscopically, gives evidence of cloudy swelling. A MANUAL OF SURGERY The Treatment of acute sapraemia must be chiefly directed to the local cause, which is dealt with by suitable surgical means. General treatment is merely symptomatic. Possibly a good purge may be advisable in the early stages, but in the later a supporting and stimulating plan of treatment must be adopted. Recently it has been proposed to deal with the acute toxaemia of peritonitis and similar conditions by the repeated injection into the veins of large quantities of saline solution (7)i. ad Oi.), and excellent results have been obtained by this means, the injections being followed by diuresis and diarrhoea, which presumably assist in the elimina- tion of the poison. (See also on Septicaemia, p. 102.) Infection. An infective process is one due to the activity of micro- organisms, which are capable of developing in living tissues — the true pathogenic bacteria or parasites. Such find an entrance into the body in many ways, as through the healthy skin, or by the mucous membranes of the alimentary canal, respiratory tract, or genito-urinary apparatus, or through wounds and abrasions ; and very often the manifestations of disease differ widely with the channel of entrance. Occasionally they are absorbed into the blood through some comparatively insignificant local lesion, and although insufficient in numbers to produce general symp- toms, yet they may find elsewhere some suitable spot for their development, and there settle, giving rise to an acute outbreak of mischief, which may attain grave proportions. Such a condition is said to be due to auto-infection. (See Acute Osteomyelitis, Chapter XVIII.) It must not be imagined that mere exposure to infection inevitably results in an outbreak of disease. Nature has pro- vided us with very efficient protective agents, and many factors enter into the question as to whether or not bacteria are able to develop in the body. 1. The dose of the organisms is an all-important element, especially in connection with the pyogenic bacteria, which are those most commonly met with, and against the activity of which we are fairly well protected. Much experimental work has been undertaken to establish this point, and it is now well-known that usually an enormous number of cocci have to be injected into the blood-stream in order to establish general infection ; a smaller number has but little, or, at any rate, a very temporary effect. 2. The vivulcnce of the organisms varies very considerably under different circumstances, and bacteria which under one set of conditions are comparatively harmless may under others become intensely noxious. It is only necessary to mention the frightful severity of some diffuse inflammatory attacks after, say, the SEPSIS AND INFECTION prick of an infected pin to emphasize the potentialities for mischief latent in some germs. 3. The resistance of the tissues is another factor in the case, the nature of which we shall allude to anon. Here we would only call attention to the fact that anything that diminishes this resist- ing power favours the chances of infection. Thus exposure to wet and cold, especially if prolonged, unquestionably leads to a decided, if temporary, lowering of the vitality of the tissues, which may then more easily fall a prey to the organisms which are so constantly present and ever ready to take advantage of any weak spot in our defensive armour. The effect of such exposure varies with the individual, but in most cases his own particular ' weak spot ' will be found out. In one a mere cold in the head — i.e., a congestion of and hypersecretion from the Schneiderian mucous membrane — will result ; in another the mischief will extend more deeply, leading to pleurisy or pneu- monia ; in a third some weak organ, such as the stomach or bladder, may be involved ; whilst in another an attack of rheumatism may be induced. A localized injury to the tissues, whether in the nature of a burn, bruise, or crush, etc., will render them more liable to microbic invasion ; whilst general con- ditions of the blood, such as occur in chronic alcoholism, Bright's disease, diabetes, etc., are always associated with a diminished power of resistance. Want of fresh air, living in unsanitary surroundings, overloading of the system with rich food, especially if the excretory apparatus of the body is not effective — all such conditions favour the activity of organisms, and render the subject more prone to be attacked. 4. The amount of suitable and available pabulum has a distinct influence, particularly in the case of the pyogenic organisms, which are facultative saprophytes, and so may readily develop in non-living material, such as blood-clot, etc., allowed to collect in or on a wound. This is followed by a local development of toxins, which, acting on the immediately contiguous living tissues, cause them to become inflamed ; local diminution of resistance follows, and may lead to actual infection, which otherwise the patient could easily have resisted. Hence the importance of draining all wounds where effective haemostasis has not been attained, and of giving an exit to all collections of blood, etc., which might become septic. In the healthy individual a wound will often heal perfectly, in spite of the presence of organisms, granting that it is dry and free from bruising. The existence of blood-clot or exudation in which the cocci can develop would be likely to favour suppuration. A good deal of confusion has existed between the terms ' contagion ' and ' infection '; and it is well to explain that by ' contagious ' is meant a disease which can only be transmitted to a healthy person by direct contact with the infected individual, or by the direct transmission of the virus through an A MANUAL OF SURGERY intermediate individual or object, provided that the organism has not multiplied outside the body. Syphilis is eminently contagious, either directly, from one person to another, or indirectly, as by smoking an infected pipe. Thus, con- tagion is merely a limited type of infection. On the other hand, many infective diseases are due to organisms which can readily develop outside the body, i.e., to the facultative saprophytes, but to these the term ' contagious ' should not be applied. Local Infective Processes are those caused at the spot of inocula- tion by the growth and development of the microbes. After a period of incubation — which varies with different organisms, and during which we may imagine that they are struggling with the germicidal action of the tissues, and establishing their foothold in the body — the bacteria begin to grow and multiply, and by the deleterious products of their activity cause irritation of the tissues and various degrees of inflammation. These inflammatory foci may remain limited, or diffusion may occur by the bacteria spreading with more or less rapidity by continuity of tissue or along lymph channels ; or the organisms may be widely disseminated through the body by the blood- vessels in the shape of emboli. A certain amount of constitutional disturbance may accompany these manifestations, due to the absorption of the toxins produced locally, whilst in some diseases the general toxic symptoms (or toxaemia) associated with some local mischief may be extremely severe, as in tetanus and diphtheria. Hence local infective processes may be classified in two divisions : (a) those in which there is but little or no general toxaemia, such as a soft chancre, a tuberculous abscess, or a mild attack of gonorrhoea ; and (b) those in which the toxsemic condition is well marked, as in erysipelas, tetanus, diph- theria, etc., the character of the symptoms varying necessarily with the different toxins. Many of the organisms which are the causes of local infection may also develop generally in the system, and produce grave constitutional affections. General Infective Processes are those in which the organisms develop and multiply in the blood-stream, so that inoculation of a sound person with the blood would almost certainly transmit the disease if a sufficient dose were introduced. Many of the bacteria producing local infection give rise to these general diseases, and, indeed, in surgery we rarely see the latter without some local condition being present to explain its origin. Septi- caemia, pyaemia, acute tuberculosis, the second stage of syphilis, anthracaemia, and probably the exanthemata, are illustrations of general infection (see Chapter VI.). Resisting or Antiseptic Power of the Tissues — Immunity. — If we are surrounded with, and if even our bodies are invaded by, so great a swarm of enemies, many of which could under suitable circumstances produce grave diseases, there must necessarily be SEPSIS AND INFECTION present within us some potent natural means of resisting their activity and development. If bacteriologists can only determine how organisms are naturally kept at bay, we may hope to elaborate along the same lines defensive measures which will be available when the enemy has broken through the first line of defence, and is actively attacking the body. That a Natural Immunity to certain diseases is present in various individuals is only hi accord with the observation that various animals are capable of resisting the action of microbes which can develop in others ; thus, rats are unharmed by anthrax bacilli, whilst the dog, the goat, and the ass are practically immune to tubercle. Again, negroes are relatively insusceptible to yellow fever, whereas white people are extremely susceptible. That this natural immunity is not absolute is also a fact, since organisms which will have no effect on a healthy animal will sometimes attack one which has been brought into an asthenic condition. It is also a well-known fact that immunity to certain diseases may be acquired in various ways : (i) Thus, one attack of many specific diseases frees the individual from the risk of contracting it again — e.g., the exanthemata and syphilis — but this freedom is not absolute, and second attacks, even of such an affection as syphilis, are not unknown. In some infective diseases — e.g., erysipelas — it seems probable that any immunity which develops subsequently is of extremely short duration and quickly passes away, leaving the patient, if anything, more prone to infection than formerly. (2) Inoculation with the actual virus of an infective disease has been utilized in the case of small-pox, choosing such a time as suits the individual, and when he is in good health. This practice has ceased since the introduction of vaccination, but the method is still utilized in the case of certain animals. Thus, an animal can be immunized by inoculating it with minute doses of a specific organism, which are gradually increased, until no more effect is produced, whatever the dose given. (3) After Pasteur had made his brilliant and most valuable discovery that the virulence of germs could be easily mitigated, and that exposure to heat for a short time sufficed to attenuate the virus in the majority of cases, much experimental work on animals became possible, and considerable success has attended the use of an attenuated virus in order to protect cattle from anthrax. (4) Going one step further, it has been found that one need not use the living organism at all, but that inoculation with the sterilized products of bacterial activity (i.e., the dead bacteria, together with their toxins) is in many diseases quite sufficient to determine immunization. A minute dose is at first administered, but as the degree of immunity increases the dose is gradually augmented, until finally the animal can receive with impunity an injection of many hundred times the dose which would have A MANUAL OF SURGERY killed it at first. The typhoid and plague vaccines are of this nature. (5) Lastly, it is now known that the blood serum of an immunized animal has considerable protective powers, and what has been termed passive immunity may be developed in this way. Most of the serotherapy of the present day depends on this property, and the serums known as antitetanic, antidiphtheritic, and antistreptococcic are all of this najture. The immunity conferred by this means is rapidly acquired, but does not generally last long. Much discussion has arisen as to the way in which the invasion of infective organisms is repelled in the body, and two chief schools of thought have arisen : (1) The French school, led by Metchnikoff, maintains that the leucocytes, and also the larger round cells derived from the connective-tissue corpuscles, described elsewhere as ' fibroblasts,' have the power of taking into their substance the microbes, and destroying them by a process of digestion. This idea of Phagocytosis is based on the results of microscopic examination, it being tolerably easy to demonstrate the presence of bacteria within the living leucocyte (Fig. 1), Fig. 1. — Phagocytosis. (Tillmanns.) In the first figure the rod-shaped organism is being absorbed or swallowed by the phagocyte ; in the second it is incorporated in its body ; and in the third it is being disintegrated. although opponents to this theory suggest that it is only dead or dying organisms which are dealt with in this way ; whilst it is also a well-known fact that the presence of organisms within cells is no absolute evidence of phagocytosis, since the latter may be invaded and finally destroyed by the bacteria, as in leprosy and gonorrhoea. As an important outcome of this doctrine has arisen the idea of Chemiotaxis, a term introduced to indicate an attractive or repulsive power exercised upon the leucocytes by foreign bodies or various chemical substances, particularly those dependent on bacterial activity. By positive chemiotaxis is meant the attrac- tion whereby leucocytes are gathered towards any tissues in which bacteria have commenced to develop ; the organisms or their products seem to have a power of causing active diapedesis and exudation of plasma, as a result of which the spread of the microbic invasion is more likely to be limited, and the inflamma- tion thus caused is protective rather than destructive. Positive SEPSIS AND INFECTION 13 chemiotaxis is to be looked on, then, as one of Nature's defences against an active and vigorous microbic attack. That it occurs cannot be questioned, though no explanation as to its origin or nature is at present forthcoming. It must be noted, however, that its existence is no absolute evidence in favour of Metchnikoff's theory, since where leucocytes are collected, there is also certain to be an increased effusion of plasma or serum. Negative chemio- taxis, on the other hand, is the term applied to a condition in which the leucocytes are apparently repelled by the organisms, probably on account of their virulent nature, though it is impossible to prove that any active repulsion exists. Both phenomena can be seen very well by inoculating the cornea of an animal with the Aspergillus nigev, as was done by Leber ; the spot of inoculation looks opaque and dull, owing to the development therein of the mycelium of the fungus, and the necrosis caused thereby ; around this is an area of clear corneal tissue which is necrotic, but free from leucocytes owing to negative chemiotaxis. Outside this, again, is a circle of infiltrated tissue, at first of a whitish-yellow colour, and finally breaking down into pus, the result of positive chemiotaxis. (2) More recently the theory of phagocytosis has been very vigorously attacked by the German school of patho- logists, and it has been maintained that the chief germicidal powers of the body reside in the blood serum and its constituents. This idea is certainly supported by the well-known fact that fresh blood serum is a bad medium for the cultivation of bacteria. Its inhibitory or germicidal properties can, however, be removed by keeping it, or by exposing it to a process of dialysis, or by heating it for about half an hour to a temperature of 55 C. Moreover, as mentioned above, the blood serum of immunized animals evidently contains certain substances of an antibacterial or pro- tective nature, and may be used as a curative agent. Certain special albuminous substances, more or less of the nature of ferments, have been isolated, to which the name of Protective Albumens or Alexines has been given. Probably there is truth in both these theories, the two different powers being called into play under varying circumstances and in different stages of the disease, the phagocytes only coming in to complete the work which has been already mainly effected by the blood plasma ; or possibly the protective albumens are developed by the leucocytes and set free into the serum. The inflammatory phenomena which supervene upon a localized infection are to be looked on as Nature's means of repelling the bacterial invasion. The irritation induced by the toxins calls forth an increased supply of blood (hyperaemia), and that involves an increased flow of blood serum, whilst leucocytes are gathered together from all parts by a process of chemiotaxis ; indeed, so marked is this latter detail that sometimes leucocytosis is induced, and a blood count will often indicate whether or not an infective 14 A MANUAL OF SURGERY process is being satisfactorily resisted (p. 47). Even should an abscess form, that is merely to be looked on as one of the means of eliminating bacteria from the system. Occasionally, however, the virulence of the organisms may be so great, or the protective powers of the individual so slight, that all opposition is borne down, and the bacteria invade the system generally, perhaps causing the patient's death. An important outcome of modern ideas as to infection and immunity is the development of means of treating infective diseases or of securing protection against them by artificial sera, containing suitable antitoxins (serotherapy). It may be antici- pated that in the near future a considerable advance will be made in this direction, but at present the chief sera in use are those directed against diphtheria, tetanus, and streptococcal affections (as preventive and curative agents). In the production of these sera some suitable animal (frequently a horse) is gradually immunized by increasing doses of the virus, and then the blood serum, which presumably contains the antitoxin, is withdrawn and utilized, after the addition of a small quantity of thymol as a preservative. Sometimes the blood serum is dried, and needs to be dissolved in sterilized water before use. The antitoxins act, as already indicated, in one of two ways — either by preventing the further development of organisms in the body — i.e., by im- munizing the individual (inhibitory action) — or by counteracting the effect of the toxins already produced (antitoxic action). Suit- able reference as to the use of these agents will be found in the sections on Tetanus, Erysipelas, etc. Having now indicated in outline how Nature repels from within a bacterial invasion of the body, and what assistance may be given to her by means of serotherapy, it only remains in this chapter to point out the methods adopted by surgeons in protect- ing their operation wounds from external contamination with micro-organisms. In this connection the name of Lord Lister will ever stand pre-eminent as that of the man who applied to surgery the principles which were being taught by Pasteur as to the microbic origin of disease. It is no exaggeration to say that Lister by the introduction of antiseptic surgery completed the revolution of surgery which had already commenced twenty or thirty years earlier owing to the discovery of anaesthesia. Antisepsis and Asepsis. The Antiseptic plan of treating wounds, originally introduced by Lord Lister, is an outcome of the germ theory of putrefaction. It has for its object the prevention of bacterial development in the wound by the use of chemical agents, some of which are true germicides, capable of destroying the bacteria, whilst others merely prevent or inhibit their growth. Innumerable methods of apply- ANTISEPSIS AND ASEPSIS 15 ing this treatment have been adopted, and multifarious antiseptic agents have been used, promiment among them being carbolic acid, corrosive sublimate, iodine, iodoform, salicylic acid, boric acid, etc. Carbolic Acid, the first antiseptic introduced by Lister, has a direct germi- cidal action in strong solutions, and an inhibitory effect in weaker ones. The crystals, when heated with 10 per cent, of water, constitute an oily fluid known as pure or liquefied carbolic acid, which is a powerful though superficial caustic, and may be employed without much fear to infected lesions, in order, if possible, to sterilize them. Thus, it is always well to treat tuberculous wounds with this fluid after scraping them, in order to destroy any portions of tuberculous material which may have escaped the spoon. The liquid carbolic dissolves in water on the application of a little warmth, and the 1 in 20- and 1 in 40 solutions are those mainly employed ; the former is an efficient and potent antiseptic, but must be used carefully on delicate skins. Carbolic acid is frequently somewhat crude and impure, and many of the irritative and toxic phenomena are due to cresylic acid and other substances which should not be present. General absorption of this reagent leads to darkening of the urine, which may become olive-green or even black in colour, and this carboluria is often associated with a rise in temperature and some intestinal irritation, whilst diseased kidneys may be seriously affected. It is more likely to occur when weaker solutions are employed than when the liquefied or pure acid is applied. The latter is seldom absorbed. Corrosive Sublimate is a valuable though very poisonous remedy, which is usually employed in solutions of 1 in 2,000, 1 in 1,000, or 1 in 500. Occa- sionally the last of these three solutions has 5 per cent, of carbolic acid added to it, constituting what is known as Lister's strong mixture. Sublimate solutions are inhibitory in action rather than germicidal, but are potent and reliable. They have less power of penetration than carbolic acid, but have no hardening or roughening influence on the skin. If, however, a dressing soaked in a sublimate solution (1 in 2,000) is kept for long in contact with the skin, it acts as. a direct irritant, and may lead to an abundant formation of pustules, owing to the activity of the germs in the deeper parts of the cutis which have not been destroyed by the antiseptic. Instruments should not be placed in sublimate solutions, as, even if plated, they soon lose their bright appearance. It must be remembered that individuals very sensitive to the action of mercury may be salivated by this agent. Biniodide of Mercury is a potent antiseptic, which has been chiefly employed in the form of a 1 in 500 solution in 70 per cent, methylated spirit for the puri- fication of the hands or of the skin of the patient. It is, of course, extremely toxic. Boric or Boracic Acid is a mild and weak antiseptic, which may be utilized when stronger remedies might prove harmful — e.g., in plastic operations and for infants. It is also useful when antiseptic fomentations are required in treating inflammatory phenomena. Iodoform is a yellow powder of characteristic and unpleasant odour, which probably acts by being decomposed in the tissues and slowly giving off iodine. Commercial iodoform is usually contaminated with a variety of germs, as may be shown by dusting it over a film of nutrient gelatine and allowing them to develop. It is therefore wise to wash the iodoform before use in 1 in 20 carbolic lotion or some such antiseptic. Its chief value is in septic or tuber- culous wounds, and, indeed, it seems to have a specific inhibitory action upon the development of the Bat. tuberculosis. It may be suspended in glycerine (10 per cent.), and after sterilization by heat injected into tuberculous tissues, joints, or abscesses; or if open wounds exist, gauze soaked in this emulsion, as it is incorrectly termed, may be packed into them with advantage. Toxic effects of very variable type may follow from undue absorption of the drug. Gastro-intestinal disturbances, vomiting, diarrhoea, colic, etc., may be the 16 A MANUAL OF SURGERY chief symptoms, but delirium and collapse often supervene. There is always an abundance of iodine in the urine. Various substitutes have been proposed in order to avoid the unpleasant smell — e.g., aristol, orthoform, etc. — but they are of doubtful value. Perhaps the best means of obviating the odour is to mix it with Jj part of Coumarin, the active principle of the Tonquin bean, which has a powerful aroma. Chinosol is a yellow substance, harmless and free from toxic qualities ; it is freely soluble in water, and possesses powerful antiseptic properties. Lysol is another useful antiseptic derivative of coal-tar. It is freely soluble in water, and as a 2 per cent, solution may be used in syringing out cavities, such as the vagina, external ear, etc. One of its great advantages is that the solution is somewhat sticky, and tends to cling to the tissues and prolong its action. Permanganate of Potash, Sanitas, and Peroxide of Hydrogen all act in the same way as oxidizing agents ; they are necessarily unstable and cannot be utilized for dressings, and are therefore chiefly employed in the disinfection of cavities or wounds already contaminated. The most potent of these is peroxide of hydrogen, which is sold as a fluid capable of setting free 10 or 20 times its volume of nascent oxygen. It is quite unirritating, and may be poured directly into a septic wound, or even into the peritoneal cavity ; forthwith it commences to effervesce, liberating its oxygen, and forming a frothy foam, which is likely to bring to the surface any loose foreign bodies. Its use is particularly indicated in the treatment of septic ulcers, carbuncles, sloughy abscess cavities, and the like. Sanitas and permanganate of potash are used in solutions of varying strength, and act more slowly ; the latter has the dis- advantage of staining the tissues with which it is brought in contact. Whilst the practice differs in various surgical schools as to the antiseptics employed and the details of their application, yet the principle in some form or other is now generally adopted. We shall here merely sketch out the routine usually practised in undertaking an operation or in the treatment of a wound. 1. The hands of the surgeon are rendered pure by scrubbing them thoroughly with soap and hot water (preferably sterilized) ; the nails are cut, if need be, and cleansed, special attention being directed to the semi-lunar folds of skin at the base, where septic material is so apt to collect. For this purpose a purified nail-brush is employed with advantage. The hands are then immersed in an efficient antiseptic lotion, such as 1 in 40 carbolic, or 1 in 2,000 sublimate solution, preceded, perhaps, for a few moments by a 1 in 500 solution of biniodide of mercury in 70 per cent, methylated spirit. The hands, once purified, should not be dried except on a sterilized towel ; but, indeed, it is better to keep them moist and redip them from time to time during the operation either in the 1 in 40 carbolic or 1 in 2,000 sublimate solution, or in intraperitoneal work in sterilized salt solution (~)\. to 1 pint). Another plan which has been used successfully and gives good results consists in immersing the hands and forearms in a saturated solution of permanganate of potash, after thorough washing with soft soap and water until they become a deep mahogany-red colour. They are then placed in a warm saturated solution of oxalic acid until completely decolorized, and are finally washed over with sublimate solution. This method causes a certain ANTISEPSIS AND ASEPSIS 17 amount of irritation of the skin of the forearms. It is possible that in many instances complete sterilization of the hands is not effected, but the surgeon must always keep complete asepsis of his hands before him as an ideal to be attained. On several occasions when our hands and those of our assistants were tested bacteriologically after the use of the biniodide of mercury and sublimate solutions they were found to be sterile, even scrapings from beneath the nails giving no reaction. Some authorities have been so concerned at the imperfection of their results that they are in the habit of operating in sterilized gloves ; it has, however, been demonstrated that such is no real protection. Careful attention to the skin after operations— e.g., the application of glycerine at night, so as to prevent it becoming rough and harsh — is a most important element in success. 2. All instruments are sterilized in a bath of carbolic lotion (1 in 20), which, it must be remembered, takes an appreciable time to destroy microbes, and therefore if during an operation a fresh instrument is suddenly called for, which has not been previously purified, it is not enough just to momentarily immerse it in the solution, but it is first placed in liquefied carbolic acid for a few seconds, and then rinsed through the 1 in 20 solution. Special care is directed towards the forceps, to see that the teeth and serrations are free from dried blood-clot and other dirt. Should an instrument fall on the floor during an operation it is, of course, not used again until thoroughly repurified. Boiling the in- struments either in carbolic lotion or, better, in a weak solution of bicarbonate of soda (1 per cent.) for five or ten minutes, is even a more certain means of rendering them aseptic, and although the surgeon may ordinarily trust to immersion in carbolic lotion, he should always boil his instruments after using them for a septic case. The water should be boiling before they are immersed, and thus discoloration will be avoided. 3. Sponges, unless very carefully treated, are a fertile source of mischief. They should be thoroughly purified in 1 in 20 carbolic lotion before use, and wrung out of a 1 in 40 solution or a 1 in 2,000 solution of sublimate during the operation. Unless the surgeon can be absolutely certain of the nurse it is better to use only a limited number of sponges — say two — and for the assistant to cleanse them in a bowl of lotion placed in a suitable position. Portions of wool, Gamgee tissue or gauze, soaked in a carbolic or sublimate lotion, or thoroughly sterilized, are often advantageously employed instead of sponges. It is never advisable to use sponges for tubercular disease or rectal operations, or for any conditions where pus is present. In cleansing sponges after an operation the following procedure is adopted : They are first thoroughly wrung out of cold water, and then placed to soak for an hour or so in a fairly strong solution of washing soda. They are then again well rinsed in 2 A MANUAL OF SURGERY cold or hot water, so as to remove all the soda, and finally immersed in a solution of carbolic acid (i in 20), in which they are kept till required. 4. The ligatures and sutures of catgut or silk are soaked for some hours in 1 in 20 carbolic lotion before use. Silk requires very thorough purification ; in order to prevent stitch suppuration, it is advisable to boil it thoroughly for at least half an hour before placing it in carbolic lotion ; it should be in loose coils, and not wound on a reel, as then only the outside strands are sterilized. Catgut, on the other hand, must not be boiled or immersed in carbolic lotion for too long, as it is apt to become rotten and break when used. It may, however, be boiled in cumol at a temperature of 165 C. for an hour without harming it ; it is then dried at a temperature of ioo° C. in a hot-air oven for two hours, and is transferred to sterilized test-tubes. Mayo Robson has advised the sterilization of catgut in xylol, which is kept at the temperature of boiling water for half an hour. A special metal cylinder with a screw top is required. The catgut is loosely wound on a reel or slide, and sufficient xylol is placed in the cylinder to cover the catgut ; the top is then screwed down, and the cylinder is placed in a saucepan of cold water, which is gradually brought to the boil, and allowed to remain boiling for half an hour. The catgut is then removed, and kept in a 5 per cent, carbolic solution in alcohol. Another simple and effective method is to place the catgut wound loosely on a glass reel in a 5 per cent, solution of formalin for twenty-four hours ; it is then immersed in boiling water for five. minutes, and subsequently kept in a solution of corrosive sublimate, 1 part, glycerine, 250 parts, and methy- lated spirit, 1,000 parts. 5. The skin of the patient is shaved prior to operation if the part is hairy, and then thoroughly washed with soap and water, and covered with an antiseptic compress for some hours. When the patient is on the table and anesthetized, a final cleansing is undertaken. The part is first well rubbed with turpentine or ether, to remove all fat and grease, and then with soft soap ; finally, it is flushed over with strong carbolic lotion, or even scrubbed, but not too energetically, with a nail-brush. Corrosive sublimate (1 in 1,000) or biniodide of mercury in rectified spirit (1 in 500) is sometimes used instead of carbolic acid. It must not be forgotten that a very vigorous use of carbolic acid will be followed by local irritation, as well as by its absorption into the blood-stream, especially in protracted operations. Again, not only does the quality of the skin vary in different individuals (as may be illustrated by contrasting that of a coal-heaver, who probably bathes once a year, with that of a child or of a lady, which is soft, clean, and delicate), but it also differs in various regions of the body, and hence the process of purification must be modified according to the thickness of the integument. Any part ANTISEPSIS AND ASEPSIS 19 where dirt may accumulate demands scrupulous attention — e.g., the umbilicus, external ear, toes, or corona glandis in persons with long foreskins. When the operation has been completed, the skin around is again cleansed with warm carbolic (1 in 40) or sublimate (1 in 2,000) lotion, after a piece of dressing has been placed as a protection over the wound. This cleansing should always be accomplished by wiping peripherally away from the centre, and any sponge or swab which has been utilized for this purpose should not be allowed to touch the wound until repurified. 6. The area of the operation or wound is surrounded with mackintoshes, and these are covered by towels wrung out of hot carbolic lotion. The latter are first soaked in a solution of 1 in 20, and then wrung out of the hot 1 in 40 solution, and kept warm until required ; the skin may be burnt if a stronger solution is used. During the operation the wound may be occa- sionally irrigated with a 1 in 40 carbolic solution, or with corrosive sublimate (1 in 2,000) ; but such is not always advisable, as it increases the amount of subsequent oozing, and is really un- necessary if one is certain as to the aseptic condition of every- thing employed. When dealing with the peritoneal cavity or the interior of a joint, the less one employs antiseptics the better, since they are always more or less irritating, and lead to desqua- mation of the endothelial lining, which it is so important to maintain intact. In fact, the rule of practice which we are endeavouring now to establish is the strictest antisepsis for the external parts, but asepsis for the interior of the wound ; one cannot always be certain, however, that this ideal has been attained, and then anti- septic irrigation may be resorted to. 7. Before closing the wound, the surgeon must use every endeavour to secure absolute haemostasis. It must be well cleansed with a sponge wrung out of hot carbolic lotion, or, if necessary, irrigated with sterilized salt solution ; it may be advisable, especially in large wounds of vascular parts, to insert a suitable drainage-tube and stitch it flush with the surface, but in many cases this is unnecessary. The incision is then closed. Wounds communicating with septic cavities, such as the mouth or rectum, should be purified with a solution of chloride of zinc (40 grains to 1 ouncej, and then powdered with iodoform, and either left open or lightly plugged ; septic contamination is by this means delayed, and even when it does occur, it may be kept under control by frequent dressing and irrigation. 8. Finally, a carefully arranged antiseptic Dressing is applied, and the part bandaged and put on a splint or in a sling, as may best suit the requirements of the case, absolute rest and quiet being essential if rapid healing is to be obtained. As to the different forms of dressing, we must content ourselves with a few words as to those ordinarily employed. Lord Lister 2 — 2 A MANUAL OF SURGERY pointed out some years back that the main essentials of a good dressing consisted in its containing some trustworthy antiseptic ingredient ; in this agent being so stored up that it cannot be dissipated before the next dressing ; in its being entirely un- irritating ; and in the capacity of the fabric to readily absorb blood or serum that may ooze from the wound. The original antiseptic dressings, viz., the carbolic and eucalyptus gauzes, and even the alembroth gauze and wool, failed to fulfil these require- ments ; but in the double cyanide of mercury and zinc gauze we have a material which is to all intents and purposes perfect. It should be moistened with carbolic lotion (i in 40,), and may then be applied to the wound without fear. Over this fresh portions are placed, taken from the stock supply, which is always kept in a mackintosh covering after being damped with carbolic lotion (1 in 20), and finally over all a liberal covering of sterilized or antiseptic wool, so as to diffuse the pressure, which is applied by means of careful bandaging. The best material for bandages is butter-cloth, since it is light and adapts itself easily to the outlines of the part. Other dressings, such as boric lint, iodoform gauze, etc., are occasionally employed, but they are not so satisfactory for general use as the cyanide gauze. 9. After-treatment.- — If no drainage-tube has been employed, and the dressing is not soaked through, it may be left untouched for seven or eight days, at the conclusion of which period it is removed, the stitches are taken out, and in all probability the wound will be completely healed. When a drainage-tube has been inserted, it is usual to take it out at the end of twenty-four or forty-eight hours ; there is no advantage in keeping it in longer, since it is only required for the removal of the sero-sanguineous fluid which exudes immediately after the operation. Should the discharge be very abundant and soak through the dressings, there is no need to remove them and redress during the first twenty- four hours ; all that should be done is to damp the stained external bandages with 1 in 20 carbolic lotion, and then pack on some more gauze or wool. This may even, if necessary, be repeated a second time. Of late years many Continental and American surgeons have been attempting to eliminate the irritating properties of chemical antiseptics by the adoption of what is called Aseptic Surgery. In this, asepsis is obtained by means of heat, the most powerful germicide in our possession ; the instruments are boiled, and dressings are sterilized by placing them for an hour or more in a hot-air chamber, raised to such a temperature as to destroy all germs, or by boiling them. Antiseptics are, however, generally used in order to purify the skin of the patient and the hands of the surgeon and his assistants, as also the ligatures and sutures. Elaborate precautions are also taken as to the dress both of ANTISEPSIS AND ASEPSIS the surgeon and his assistants, and even of onlookers ; whilst operating theatres, tables, etc., are disinfected in a careful manner. This plan has been employed with much success, but requires more attention to details than does the antiseptic method. Where our assistants are constantly changing, as in a large teaching hospital, and where many hands are engaged in the work, there is much greater risk of failure. It is only natural that we, who have had the privilege of working with Lord Lister, and have seen the excellent results following the intelligent use of antiseptics, should still to a large extent cling to that line of practice, which certainly can be carried out with more precision under .all circumstances, both in private and hospital, than the other plan, the objects of which may at any moment be defeated by some slight inadvertence or oversight. At the same time, we are free to admit that aseptic methods have much to commend them ; all antiseptics are more or less irritating, and there can be no question that the less we use them the better. Moreover, boiling the instruments is more certain to disinfect them than immersion in antiseptics ; they are subsequently laid in a bath of sterilized salt solution, or even water. Sponges are replaced by swabs of sterilized tissue or gauze ; aseptic wounds are washed out with salt solution, if any irrigation is required ; and the towels around the area of operation are merely sterilized by placing them in a hot-air chamber or are boiled. To sterilize towels or textile fabrics generally, it must be remembered that they must be placed loosely in the sterilizer, as otherwise the heat cannot reach between their various folds and layers. Dressings may be merely sterilized, but when one's work lies in a large city hospital, with impure and often contaminated air around, we believe that the welfare of our patients is best consulted by employing antiseptic dressings, and the results we have obtained with the double cyanide gauze are such that we can wish for nothing better. A few other micro-organisms exist besides the bacteria, but as they play a comparatively insignificant part in surgery, no lengthy notice of them is required. i. Some of the Fungi, especially the Hyphomycetes, are characterized by the growth of a mycelium or mass of interlacing fibres or threads, arising from which are the spore-bearing conidia, whence multiplication of the growth ensues. A great variety of fungi is found in Nature, but the more important pathological conditions due to their development in the body are as follows . Thrush, due to the Oidium albicans. Ringworm, due either to the Microsporon Audoini (the common type), or to the Tricophyton megalosporon endothrix or ectothrix. Favus, arising from the Achorion Schonleinii. Pityriasis versicolor, due to the Microsporon furfur. Keratomycosis, or parasitic ulcer of the cornea, is due to fungi of the aspergillus or mucor type (common moulds), which mav also be found developing in the bronchi (pneumomycosis), or in the external auditory meatus (otomycosis). A MANUAL OF SURGERY Actinomycosis (p. 148) is dependent on the growth in the tissues of the ray fungus, or Actinomyces, although there is some question as to whether these organisms should not be classed as bacteria. 2. The Yeasts or Blastomycetes multiply by a process of gemmation or budding. They are responsible for many forms of fermentation, e.g., the alcoholic or acetous, and are found in certain peculiar forms of dermatitis. The hypothetical parasite of cancer is now regarded as belonging to this class. 3. The Protozoa constitute a group which can be classed either as animal or vegetable, and consist in their earlier stages of masses of naked nucleated protoplasm, which may later on become covered with membranous envelopes, through openings in which pseudopodia are protruded. They form a large and varied class, the simplest type being the amct'ba ; but their influence in pathology is not yet fully worked out. It is supposed that the following varieties are of pathological importance : Amoeba are known to occur in certain forms of colitis, and also in some varieties of hepatic abscess. Malaria is due to the development of a protozoon, the Plasmodium malaria. The Psorospermia, which occur not unfrequently in animals, are members of this group, and it is still a moot question whether the coccidia-like bodies found in Paget's disease of the nipple are really living parasites, and if so, whether they have any causative effect on the origin of the disease (p. 174). Molluscum contagiosum is another condition which has been attributed, probably on very insufficient grounds, to these organisms. CHAPTER II. INFLAMMATION. ' Inflammation is the succession of changes which occur in a living tissue when it is injured, providing the injury is not of such a degree as to at once destroy its structure and vitality.' Such was the definition given in 1870 by Burdon Sanderson, and it is sufficiently accurate if one amplifies the term ' injury ' to include bacterial invasion, and excludes the final processes of repair. Formerly inflammation was looked on by pathologists as always of a destructive and harmful nature, but at the present time bacteriological research has demonstrated that it is often rather of a protective or conservative character, being Nature's means of limiting the advance of noxious micro-organisms, and of finally eliminating them from the system. Occasionally, how- ever, the tissue reaction called into existence by bacterial invasion is so severe as to increase, rather than diminish, the risks of the patient. The actual phenomena of inflammation are perhaps best studied in the web of a frog's foot. If this is spread out and examined under the microscope, the following evidences of normal physio- logical activity may be seen : (a) the flow of blood through the vessels, as indicated by the movement of the corpuscles, the red ones, each separate from the other, flowing in the central or axial current, the leucocytes occasionally seen amongst the red, or here and there one may be noticed rolling lazily along in the inert corpuscle-free peripheral portion of the tube ; (b) the constant rhythmical changes in calibre of the arterioles independent of the heart's action, and influencing in a marked degree the flow through the capillaries ; and (c) the changes which occur in the pigment-cells, which represent the connective tissues of the part, and which are mainly due to the influence of light, the cells con- tracting or expanding as the light is increased or diminished. If now a crystal of common salt, or some such irritant, is applied to the web, the early vascular phenomena contributing to inflammation may be readily observed. 24 A MANUAL OF SURGERY I. — The Vascular Changes in Acute Inflammation. A momentary contraction may perhaps be noticed in the arterioles of the part, but this is only apparent in inflammations produced artificially, and is of no known significance. It is followed by a condition of Hyperemia of the inflamed area, as manifested by a rapid and lasting dilatation of the vessels, accom- panied by an increase in the rapidity of the blood-flow (accelera- tion). This is a peculiarly vital phenomenon, and opposed to the hydrostatic law that when fluid is flowing through a tube or channel at a fixed pressure, if the lumen is suddenly widened, the rate of the blood-flow is diminished. It is probably brought about by some change in the local vasomotor mechanism present in the smaller arterioles. This increased rapidity of the flow lasts for a while, and then the current gradually becomes slower and slower (retardation), as if an ever-growing obstruction existed to the passage of the blood ; then a period of oscillation will be noticed, the blood-current swaying forwards and backwards, and finally a condition of stasis or still-stand is arrived at, which may or may not end in actual thrombosis or intravascular coagulation. During this period changes have occurred in the behaviour of the blood contained in the vessel, due in all probability to certain invisible changes in the vessel walls and not to any alteration in the blood. Thus, almost as soon as dilatation occurs, the leucocytes collect along the walls in the peri-axial inert layer, seeming, as it were, to fall out of rank ; this process first commences in the veins, but can be observed in all the vessels. The red corpuscles also, which formerly had flowed along separately, now tend to adhere to the vessel walls and to each other, running into rouleaux. The second factor in the vascular changes must now be con- sidered, viz., Exudation, a proceeding which becomes evident at a very early stage. Every element in the constitution of the blood participates in this process. It has been already mentioned that the leucocytes collect in the peri-axial layer, a phenomenon due partly to the retardation of the blood-stream, whereby the relatively heavier bodies separate from' the lighter, and in part due to positive chemiotaxis (p. 12). The next change consists in the passage of the leucocytes through the vessel walls, especially those of the smaller veins and less often of the capillaries. The process is a strictly vital one, brought about by amoeboid move- ment ; a small arm or outgrowth of the leucocyte (pseudopodium) is inserted between the endothelial cells lining the vessel, whose cohesion has been probably interfered with by the inflammatory process. Into this arm the protoplasm of the leucocyte flows, still further separating the endothelial elements, and thus the cell passes through the wall into the surrounding connective tissues (Fig. 2). The migration of the leucocytes only lasts as long as the blood in the vessel is actually circulating ; as soon as throm- INFLAMMATION 25 bosis occurs, migration ceases. When the white corpuscle has escaped into the peri-vascular tissues, it may undergo various changes. In the first place, it may die and be at once dis- integrated, setting free fibrin ferment, and thus assist in the production of the inflammatory coagulum to be shortly described ; or, again, it may serve as pabulum for the larger fibroblastic cells which soon make their appearance, arising apparently from the multiplication of the connective-tissue corpuscles in the neighbour- hood ; or, once more, it may find its way back into the circulation Fig. 2. — Diagrammatic Representation of the Vascular Phenomena of Inflammation. (After Keen and White.) Two thin-walled venules are seen, and several capillaries. The red corpuscles are still occupying the axial portion of the tubes, whilst the periphery is crowded with leucocytes, which in several places are in process of migra- tion into the surrounding cellular tissue. through the lymphatics, or be transformed into a pus corpuscle ; moreover, prior either to disintegration or transformation into a pus corpuscle, it may attack and assist to remove any dead tissue which exists in the neighbourhood of the inflammatory focus, whilst a phagocytic or microbe-destroying function is also sub- served. In fact, the leucocytes may be looked on as the scavengers of the body, or as advanced guards, which, at the onset of mis- chief, are thrown out from the vessels as Nature's first line of defence against the invading forces, their chief duty being to 26 A MANUAL OF SURGERY remove all damaged and noxious material, and then, having limited the spread of the destructive process, they in turn give place to the larger and more useful fibroblastic cells which are the active agents in the process of repair. The red corpuscles pass through the walls of the capillaries by a process of diapedesis, the result of simple mechanical pressure ; this usually occurs only in very acute attacks. When once external to the vessels they are broken up and their colouring matter diffused through the tissues. The liquor sanguinis is also extravasated. This is merely an exaggeration of a normal process, although in health the lym- phatics are capable of removing all the fluid exuded. In patho- logical conditions the amount of plasma which passes through the walls is excessive, and although for a time the lymphatics of an inflamed region do increased work, yet the transudation is soon greater than they can deal with. If the fluid escapes into the tissues, it undergoes coagulation by meeting the necessary coagulating media developed from the breaking-down leucocytes ; inflammatory lymph forms locally, whilst the serum collects in the meshes of the tissues, constituting an inflammatory form of oedema ; if there is a sufficient breach of surface, the serum drains away. If the exudation takes place from a serous surface — e.g., pleura, peritoneum, synovial membrane, etc. — the fluid distends the cavity ; it is at first spontaneously coagulable (i.e., consists of plasma) ; if coagulation occurs, the clot or lymph either forms an adherent plastic mass on the surface or floats free in the fluid. Looked at, therefore, simply from a vascular point of view, Inflammation = Hyperemia + Exudation. In addition, however, to these vascular phenomena, which can be readily seen in a frog's web, there are others which cannot be so easily observed, and which may be described as II.- -The Tissue Changes in Inflammation. Great differences of opinion have been in existence as to the part played by the tissues in inflammation ; but although there may still be points to be elucidated, yet the general opinion of pathologists is at the present day tolerably well defined. Formerly, in accord with Virchow's cellular pathology, it was held that the tissues were the all-important element, and that the immense number of cells which collect in an inflamed area was entirely due to the proliferation of the connective-tissue corpuscles. Lister, as far back as 1858, maintained the passive condition of the tissues ; and when Cohnheim, in 1867, described the migration of the leucocytes, everything in the process of imflammation was attributed to them. Since that date Senftleben and many others IN FLA MM A TION 25 have worked at the same problem, and a considerable amount of fresh light has been thrown on the subject by experiments con- sisting in the insertion of foreign bodies into the peritoneal cavity, and by others directed towards demonstrating the phagocytic functions of leucocytes and the influence of chemiotaxis. Much of the difficulty which has enshrouded the question has arisen from a confusion between the processes of inflammation and repair. At one time repair was always looked on as of an inflam- matory nature ; but it is now admitted that although no lesion in the body can occur without a certain amount of local inflammatory reaction, yet the true process of repair is not of that nature. Again, it is important to differentiate between the changes which occur in acute and chronic forms of inflammation, and between those met with in superficial and deep parts, whilst the bacterial origin or not of the process must also be taken into account. In acute parenchymatous inflammation there is now no question that the primary effect on the tissues, at any rate in inflammations due to bacterial activity, is to paralyze them ; as they become infiltrated with the products of microbic multiplication, the proto- plasm within the cells coagulates and refuses to take up the ordinary stains, constituting a condition known as Coagulation Necrosis. This necrotic tissue is in time entirely absorbed by the leucocytes, or is liquefied by the activity of bacterial toxins, so that it is replaced by a mass of small round cells, sometimes known as Embryonic Tissue. According to the relative vitality and vigour of the individual and the bacteria, this mass may in turn either be replaced by larger round cells derived from the connective tissues (fibroblasts), by means of which most of the leucocytes are absorbed, and repair is brought about ; or the whole mass may be liquefied and break down into pus. In non- bacterial inflammations of superficial parts the amount of effusion between the individual cells may be so excessive as to separate and disintegrate them, and thus Colliquative Necrosis may be induced, as occurs in the formation of blisters after a burn. Once more, acute inflammation of mucous membranes may be associated with active proliferation of the surface epithelium, as in catarrhal and gonorrhoeal affections. In chronic inflammations, on the other hand, active cell pro- liferation is a most important element in the process, resulting in sclerosis and induration of the parts. This, however, mainly affects the interstitial tissues, and thereby the true structure of the organ may be impaired. Terminations of Acute Inflammation. These vary according to the cause of the mischief, the intensity of the process, and the powers of resistance possessed by .the individual attacked. The causes described at p. 33 naturally fall 28 A MANUAL OF SURGERY into two main classes, according to whether or not they are asso- ciated with bacterial activity. Speaking generally, lesions not caused by bacteria, such as those following a blow or a burn, are characterized by much exudation of fluid, which is of low specific gravity, does not contain much albumen, and does not coagulate in the tissues ; the amount of cellular infiltration is slight, no peptonizing ferment is present, and the results are usually localized. Bacterial irritants, on the other hand, produce more infiltration of the tissues, since the exudation, which is rich in albumen, coagulates in the tissues ; disintegration is likely to follow, as peptonizing ferments are often present, and the inflammation is more likely to be of a spreading nature. The intensity of the irritant also modifies the process, since, if slight, it has a somewhat stimulating effect on the tissues, whilst severe lesions may result in tissue destruction, even amounting to gan- grene. Then, too, the type of tissue affected is important, since the same cause may lead to very different results. The more highly organized and important parts are always more vulnerable than the simpler forms of connective tissue, and this in spite of the fact that the former are usually better supplied with blood. Thus, the growing end of the diaphysis in a child is a most deli- cately organized region, and hence is peculiarly liable to serious destructive inflammation from bacterial agents, which would do little harm if developing under similar circumstances in the sub- cutaneous connective tissues. The actual terminations of acute inflammation may be described under five distinct headings : i. Resolution, or the restoration of the part to its natural condi- tion and function. This can only occur when the injury has not been so severe as to destroy the vitality of the affected tissues, and when the vascular changes have not gone further than stasis. When once thrombosis has taken place in a vessel, the parts can never be restored to the status quo ante. The phenomena of reso- lution are merely those of inflammation in a retrograde order — viz., an oscillatory movement first manifests itself amongst the corpuscles, and then the blood-stream is gradually restored, slowly at first, and more and more rapidly afterwards. The adhesiveness cf the corpuscles disappears by degrees, but it will be some time before the peripheral inert layer can be seen. The exuded leuco- cytes find their way back into the circulation either through the vessel walls, or to a greater extent via the lymphatics, or else they are disintegrated in the tissues and absorbed. The fluid exuda- tion is removed by the lymphatics. For some time after an acute attack the vessels of the part are dilated from simple loss of tone, but this also gradually disappears. 2. Organization, or Fibroid Thickening, occurs when the in- flammatory process is not arrested until after the supervention of thrombosis, but has stopped short of suppuration. The parts INFLAMMATION 29 are then not restored to their original condition, but changes take place in the cellulo-plastic exudation and in the connective tissue around, which result in its transformation into cicatricial tissue, and hence the details of the process will be similar to those described under the heading of ' Repair of Wounds ' (Chapter VIII.). Very similar conditions follow when the in- flammatory process becomes chronic, as is not uncommonly the case. 3. Suppuration is always due to invasion of the affected region by pyogenic organisms, which disintegrate and liquefy not only the tissues involved, but also in part the exudation (Chapter III.). 4. Ulceration is produced on the surface of either skin or mucous membrane by the action of an irritant of such nature and intensity as to destroy its vitality, though without evident sloughing (Chapter IV.). 5. Gangrene is a less common result of inflammation, and is due either to the intensity of the virus or to the weakness of the tissues attacked (Chapter V.). It occurs not unfrequently in bone, constituting the condition known as necrosis, and is then due mainly to the strangulation of vessels within the narrow lumen of the Haversian canals by an exudation which is often relatively small in amount. Clinical Signs of Inflammation. These may for practical purposes be described under the four headings given by Celsus, viz., heat, redness, swelling, and pain, with the addition of a fifth, viz., impairment of function. Heat. — An inflamed part feels hot to the touch, and the tem- perature, if taken by a surface thermometer, is definitely raised above that of the surrounding skin. The cause of this is the increased amount of blood flowing through it, for the temperature of an inflamed area is never higher than that of the blood at the centre of the circulation, i.e., in the heart. Necessarily, where active chemical and pathological changes are occurring, as in an inflamed tissue, a certain amount of heat is produced ; but it is relatively so infinitesimal in quantity that it may be neglected. The cause of the increased temperature of the blood is noted elsewhere (p. 32). Redness is due to the hyperaemic condition of the inflamed part, and its intensity and characters vary considerably. In the early active hyperemia the colour is a bright rosy-red, fading quickly on pressure, and returning with equal rapidity. In the stage of retardation the redness is more dusky, since the blood is longer in passing through the capillaries, and so loses more of its oxygen ; the colour does not disappear or return so rapidly, and a slight yellowish tinge often remains from extravasated haemoglobin. When stasis is reached, and a fortiori when thrombosis, pressure A MANUAL OF SURGERY does not remove the red colour, and, should such a state persist for long, permanent pigmentation may remain. The redness is not always most marked at the focus of the disturbance, since the portion inflamed may be non-vascular, e.g., the cornea or articular cartilage ; in the former of these, the redness is most marked in the ciliary region as a zone of deep pink injection. The same absence of redness is observed in an inflamed iris, owing to the excess of pigment hiding the dilated vessels ; but in both cornea and iris, the inflammation may in rare cases be so prolonged or acute as to cause these structures to become evidently vascular — in the one case from the formation of new vessels, and in the latter by the total removal and absorption of the pigment. Swelling arises from the same two causes, viz., hyperaemia of, and exudation into, the part. Necessarily the amount of tumefaction depends upon the acuteness of the disturbance and the distensibility of the tissue, and -in measure varies inversely with the amount of pain. In some cases where the inflamed area is covered by a thick and firm fascia, not only is the tensive pain very considerable, but swelling may occur away from the inflamed area, e.g., over the back of the hand in palmar abscess ; where the inflammatory products escape into lax tissues, the subjective phenomena are minimized. Similar illustrations of the occurrence of cedema at a distance are to be seen in inflammations of the sole of the foot, in the swelling of the eyelids when the scalp is inflamed, and of the cheek in inflammation of the dental periosteum. Swelling due to inflammation, though diminishing post-mortem, does not entirely disappear. Pain. — This results from the mechanical irritation of the peri- pheral nerve terminals, both by the increased arterial tension and by the pressure of the exudation, so that it is much greater if, from the density of fascial or fibrous investments, swelling cannot readily occur, e.g., in the palm of the hand, or in the eye or testicle. Possibly the exudation may also have some direct chemical action on the nerve terminals. A marked feature of inflammatory pain is that it is always aggravated by pressure, whether intrinsic — i.e., by increasing the blood-pressure — or extrinsic, from outside agencies. Thus, if an inflamed finger or hand is allowed to hang down, the pain is much increased, whereas elevation causes speedy relief. The pain of suppuration is throbbing in character ; of an inflamed mucous membrane, scalding, burning, or gritty ; of an inflamed serous membrane, stabbing ; of inflamed bone, aching or boring, and often worse at night ; of an inflamed testicle, sickening. When the organs of special sense are inflamed, there may be little real pain, but much exaggeration of the special sense, e.g., flashes of light in retinitis and noises in the ears in otitis interna. The pain is not limited only to the inflamed part, but is some- INFLAMMATION 3i times experienced in distant regions, either through a similarity of nerve-supply or from the fact that a sensory stimulus is always referred by a patient to the end of the affected nerve. For example, in hip disease the chief pain is often felt in the knee, because the two joints have a similar nervous supply. In renal calculus or colic, pain is referred along the course of the genito-crural nerve into the groin and front of the thigh, and is often accompanied in the male by retraction of the testicle on the side affected. In spinal caries pain is frequently experienced in the terminal branches of the nerves issuing from the part affected, e.g., the so-called ' belly-ache ' of dorsi-lumbar disease. Impairment or Loss of Function is due sometimes to the mechanical difficulty of using a swollen organ, sometimes to the pain elicited by such attempts, but often to the paralyzing effect of the inflammatory process, and this in infective lesions results from the direct influence of the toxins on the protoplasm of the cells affected. Thus, an inflamed eye can see but little; a muscle, when inflamed, is naturally kept at rest; glandular organs, e.g., the liver and kidneys, have their functions, if not lost, at least much diminished ; and many similar illustrations might be added. General or Constitutional Symptoms. These vary considerably according to the part involved and the cause of the inflammation, (a) If an important organ, such as the heart or kidney, becomes inflamed, grave mechanical and physio- logical trouble may result, (b) Inflammations due to traumatism, in which bacteria play no part, are not uncommonly associated with a temporary pyrexia, probably due to some such substance as fibrin ferment, (c) When of septic or pyogenic origin, inflam- mation is almost always associated with well marked fever, and it is sometimes astonishing to note how much disturbance a small bead of pus under tension will produce, (d) In certain infective inflammations a characteristic toxaemia is produced, due to a specific action of the toxin — e.g., in tetanus, convulsions are caused ; whilst in diphtheria, fever and perhaps paralytic pheno- mena are alike produced. It is only necessary at this place to deal very briefly with the subject of Fever or pyrexia. The general characteristics of the febrile state consist in a greater or less elevation of temperature, accompanied with a corresponding acceleration of the rate of the heart-beat and of the respirations. If it continues for any length of time, the patient becomes thin and emaciated, and loses muscular power. The mouth is dry and the tongue furred ; and in the later stages, where a fatal issue is apprehended, the lips and teeth are usually covered with sordes (or accumulations consisting of inspissated mucus and food debris). The appetite is impaired, digestion is imperfect, and the bowels constipated ; any motion 32 A MANUAL OF SURGERY passed is very offensive. The urine is scanty and high-coloured, and owing to the excessive tissue change contains an unusual amount of urea and urates. The excess of urea is demonstrated clinically by adding an equal part of cold nitric acid in a test-tube to some urine, when crystals of nitrate of urea will form on the top of the fluid, giving rise to a mass somewhat resembling sugar- candy in appearance. The skin of a febrile patient is often dry. Causes of Fever. — The temperature of the body, it is well known, is controlled by a principal heat-governing centre in the medulla, assisted possibly by accessory centres in the cord, and is maintained by the establishment of equilibrium between the amount of heat lost from the skin, by the breath, and in other directions, and the amount of heat produced by the tissue metabolism occurring in the viscera generally, and especially in the voluntary muscles. Pyrexia is necessarily due to one of two causes, viz., a decreased loss of heat, or an increased production. The former is a scarcely tenable proposition when we look at the patient's condition, and hence we are driven to conclude that fever is due to increased activity in the heat-forming tissues, especially the muscles, a fact which explains the rapid emaciation and loss of strength under such circumstances, and the presence of a large amount of extractives in th-3 urine. In all probability this increased activity is due to the excitement of the heat-producing centre by some pyrogenous body developed in connection with the local inflammatory process. Experiments have shown that the fibrin ferment, as well as many of the toxins produced by the action of micro- organisms, if injected into the circulation in a pure state, possesses such a power. In regard to the symptoms of fever, it may be stated briefly that they are in large part due to the effect produced by the increased temperature or the toxic products circulating in the blood upon the constituent cells of glandular and other organs. The phenomena in question are termed by different path- ologists 'acute or cloudy swelling,' 'granular degeneration,' 'albuminous infiltration,' etc., and are characterized by the organs becoming soft, friable, and more or less swollen. The secreting cells of glands are increased in size, and the protoplasm becomes markedly granular, so that the nucleus can only be distinguished with difficulty. The granules are albuminous in character, clearing up completely on the addition of acetic acid. A similar change is also evident in the fibres of the cardiac muscle, which lose their striation and become granular, a condition which must considerably interfere with their contractility. The effect produced upon the glands of the digestive system explains many of the febrile manifestations, inasmuch as their function is largely impaired. The salivary and buccal glands are unable to excrete the normal amount of saliva, and hence the mouth becomes dry. Gastric diges- tion is interfered with in the same way. The bile is not efficiently produced, and hence its fat-emulsifying properties are diminished, as also its cathartic powers, whilst the patient cannot properly digest fats, and is constipated. Various terms have been applied to different types of surgical fever, e.g., sthenic and asthenic, which sometimes depend as much upon the constitution of the patient as upon the nature or cause of the affection. By Sthenic inflammatory fever (Greek, a-devos, strength) is meant that condition in which pyrexia and all its accompanying symptoms are well marked. It occurs mainly in young healthy adults of sound constitution, as, for example, when a young man is suddenly attacked by acute pneumonia, or when an acute abscess is forming. Asthenic inflammatory fever (Greek, do-Oevos, without strength) is characterized by the tendency to INFLAMMATION exhaustion and collapse associated therewith. It is met with in debilitated subjects and those exhausted by vicious habits, but may also occur at the close of a long period of pyrexia, e.g., in the third week of typhoid fever ( = the typhoid state). The absorp- tion of products of putrefaction and the occurrence of acute infective blood-poisoning also induce fever of this type. Causes of Inflammation. Predisposing Causes. — The conditions which predispose to in- flammation may be conveniently divided into the local and the constitutional. The local causes include the following more important conditions : i. Defective circulation whether due to chronic anaemia, as in a limb with rigid calcareous arteries, or to passive congestion, as in a leg with varicose veins. 2. Loss or impairment of the nervous supply to a part, render- ing it less resistant to external irritation either from loss of sensation, diminished trophic control of the nervous centres, or circulatory changes. 3. One attack of inflammation often leaves a part weaker and more liable to recurrence. The general or constitutional predisposing causes are those which tend to depress the general vitality, e.g. : 1. Old age, when the body as a whole suffers in its nutrition. 2. Weak action of the heart, disturbing the vascular supply of the' organs and members of the body. 3. An unhealthy condition of the blood, as from (a) the addition of some abnormal constituent, as in alcoholism, plethora, lead, mercury, or phosphorus poisoning, septic diseases, diabetes, etc. ; (b) the insufficient elimination of excreta, as in Bright's disease or gout ; (c) the absence of some normal constituents, as in albu- minuria or anaemia. 4. The presence of some constitutional disease, dyscrasia or diathesis, as syphilis, tubercle, rheumatism, etc. Exciting Causes. — The active agent in the production of any inflammation is the existence of some irritant which acts for a shorter or longer period upon the tissues. The different forms of irritants are infinite in number, but may be grouped under the following four headings : 1. Mechanical or traumatic causes, such as direct violence, friction, tension, pressure, etc. 2. Causes which act through changes of temperature, either heat or cold. 3. Electricity, either as applied by the surgeon in the form of the faradic or galvanic current, or through the agency of lightning or the strong currents used for lighting purposes. 4. Toxic irritants, under which may be included : (a) Chemical agents, such as strong acids or alkalies. 3 34 A MANUAL OF SURGERY (b) Vegetable irritants, e.g., croton-oil, oil of mustard, etc. (c) Animal irritants, such as cantharides, and insect or reptile bites. ((/) The development of micro-organisms within or without the body (see Chapter I.). Varieties of Inflammation. Many different terms are used to indicate the manifestations of the inflammatory process in the body, and to some of these we must now direct attention. A Catarrhal inflammation is one affecting mucous membranes, which in the early stages become dry, vividly red, and the seat of a burning or scalding pain, whilst in the later stages there is free secretion of mucus, muco-pus, or pus. Pathologically, this pro- cess is accompanied, as are all active inflammatory changes, by hyperaemia and exudation. At first the mucigenous function of the membrane is abrogated, and any extravascular exuda- tion passes into its substance, causing it to become swollen. Proliferation of the epithelium soon follows, resulting in an increased formation of mucus ; as the membrane becomes more and more infiltrated with leucocytes, these are added to the dis- charge, which is thus transformed into muco-pus, or even pus. Small ulcers may develop from the loss of superficial epithelium, but this is an exception rather than the rule. Microscopic examination of the discharge reveals pus cells, leucocytes, and epithelial elements in various conditions, some containing globules of mucin, and some of the normal type. This form of inflamma- tion is caused by bacteria, or by the action of local irritants, or to what is known as ' taking cold.' A Croupous (or plastic) inflammation is one characterized by the formation of a firm, false membrane, due to the coagulation of the plasma exuded from the vessels, the resulting fibrin being deposited on the surface. When involving a serous membrane, such as the pleura, peritoneum, or synovial membrane, it gives rise to a layer of plastic lymph, which may organize into adhe- sions ; it is also seen in the alveoli of the lungs in lobar pneumonia. On mucous membranes, such as the conjunctiva or that of the pharynx, it occasionally forms white, flaky masses, which can readily be detached, leaving an injected surface below, with merely one or more oozing points, and no loss of substance. A Diphtheritic inflammation is due to a special organism — the Bacillus diphtheria — and is characterized by the formation of a membranous exudation with which are incorporated the superficial layers of the epithelium, so that it cannot be removed without leaving a raw surface. The bacilli develop in this false membrane and produce toxins, which by their absorption give rise to the constitutional symptoms of the disease. IN FLA MM A TION 35 The term Phlegmonous is now but rarely employed. It was formerly applied to any superficial inflammation where the local phenomena were well marked. Parenchymatous and Interstitial are terms which indicate that in an inflamed organ or gland the process is mainly limited, either to the actual and active substance of the organ, or to the support- ing fibrous tissue. The term Metastasis was formerly employed to indicate a sudden transference of an inflammatory attack from one place to another without apparent cause. Increased knowledge of pathology has explained away almost all the formerly-described illustrations of metastasis, and, indeed, the use of this term is now almost limited to the inflammation of testis, ovary, or breast which follows mumps. Treatment of Acute Inflammation. It is only possible to deal here with the general principles which guide us in the treatment of inflammatory affections. The method of application of these to different parts of the body will be described hereafter. The Local Treatment may be indicated under four headings : i. Remove the exciting cause, if evident, and any contributory causes when feasible. This is not a difficult matter when the lesion is a gross one, and the exciting cause tangible — e.g., a foreign body embedded in the conjunctiva or cornea, or a piece of dead bone lying at the bottom of a sinus. Inflammatory tension from pent-up effusion is readily relieved by an incision, or an abscess opened. In some cases, due to bacterial invasion, it may be practicable to totally excise a local focus — e.g., a malignant pustule — whilst in others, such as a carbuncle, one has to trust to scraping away the sloughy and infiltrated tissue with a Volkmann's spoon, and then, after purification with liquefied carbolic acid or peroxide of hydrogen, the wound is carefully stuffed with gauze. In bacterial inflammation of a more diffuse type, it is usually impossible to remove the cause, and one has then to trust to other measures. 2. Keep the inflamed part at vest. Wherever inflammation exists, both physical and physiological rest should be obtained as far as possible. Thus, an inflamed joint is immobilized by a splint ; an inflamed mamma needs both support and the fixation of the arm, whilst if in a condition of physiological activity this must be checked by suitable treatment ; an inflamed cornea requires the application of a pad and bandage to prevent the friction of the eyelid ; an inflamed retina must be given physiological rest by exclusion of the light. 3. Reduce the local blood -pressure and hyperaemia, and thus diminish both exudation and pain. Elevation of an inflamed 36 A MANUAL OF SURGERY limb may secure this end, and is a most essential element in the treatment of all inflammatory conditions of the leg, for it is a well-known fact that emptying the veins by gravity in an elevated limb leads to reflex contraction of the arteries. Local blood-letting by leeches, punctures, scarification, and wet or dry cupping, is useful in suitable cases, and sometimes gives imme- diate relief. It may be as well to mention that a leech can withdraw about 2 to 4 drachms of blood, and that it should not be applied over a large subcutaneous vein, or to parts, like the scrotum or eyelids, where there is much subcutaneous tissue of a loose texture, in which extravasation readily occurs. The bleeding from a leech-bite usually ceases spontaneously, but may require the application of slight pressure. In diffuse inflammation of the cellulitic type free incisions are beneficial, partly on account of the relief of tension and pain which follows the escape of blood and retained discharges from the tissues, but also because it determines a free flow of blood serum, and as this possesses antitoxic and germicidal properties, it assists in bringing the inflammatory process to an end. Cold wisely utilized is of the greatest service in combating inflammation, causing contraction of the arterioles, and so re- ducing the hyperaemia. It should only be used in the early stages, and never when suppuration is threatening, as, although it may cause local depletion of the bloodvessels, it at the same time depresses the vitality of the part, and so may do more harm than good. Again, it should be used with the greatest care in old people, from fear of causing sloughing of the skin. There are various methods of applying it, as by means of an ice-bag ; or by irrigation from a vessel, suspended over the part, containing iced water or lotion, from which strips of lint descend to envelop the inflamed area ; or a piece of lint wrung out of evaporating lotion may be placed directly on the part ; or, better still, the iced water may be run through a coil of leaden pipes (known as Leiter's tubes), fitted carefully to the inflamed region. Under any circum- stances the cold must be continuous, and not intermittent, as otherwise the alternating periods of anaemia and hyperaemia will have a baneful rather than a beneficial influence. Heat, especially when combined with moisture, is very largely used in treating inflammatory affections, and acts in a diametri- cally opposite way to cold by relaxing the vessels and tissues, thus reducing the tension and pain ; it also favours the activity and vitality of the part by increasing the vascular supply and facilitating lymphatic absorption. When suppuration is threaten- ing, the application of warmth and moisture hastens the process. For subcutaneous lesions, fomentations, medicated or not with opium or belladonna, or spongiopiline wrung out of hot water, or simply dry heated cotton-wool, may be employed. When an abscess is forming, nothing can be more soothing and satisfactory INFLAMMATION 37 than a linseed-meal poultice, provided that the abscess is not allowed to burst into it. Poultices should never be applied to an open wound or abscess, unless the latter is in a very septic con- dition, and then they can be rendered more or less aseptic by making them with hot carbolic lotion (1 in 30). The boracic poultice or fomentation is most useful in many superficial inflam- matory affections due to sepsis, dirt, and want of attention. It consists in the application to the part of a portion of boracic lint wrung out of a hot boric acid solution (1 in 20), and covered with oiled silk or guttapercha tissue. 4. Prevent the access of fresh sources of irritation or infection, such as those due to putrefactive changes in an open discharging wound. The General Treatment of inflammation varies considerably with the condition of the patient, and as to whether he is strong and healthy, or weakly. Those who are depressed in health, or who may be expected readily to become so from the continuance of the febrile state, need to be carefully supported by a tonic plan of treatment, whilst at the same time attention must be directed to the elimination of toxic bodies by suitable purgatives, dia- phoretics, and diuretics. Quinine may be given with great benefit, as also diffusible stimulants, such as ether or carbonate of ammonia, whilst the recovery of patients lying in a typhoid state of exhaustion will absolutely depend on the administration at short intervals of nourishing fluids, combined with stimulants. In the sthenic type of inflammatory fever, ' antiphlogistic ' means may be freely employed so as to reduce the general blood-pressure and remove irritating matters from the system, e.g., a smart purge, followed by low diet and abstinence from alcohol for a few days ; but in other instances where the blood-tension is high, as indicated by a large and full pulse, and the local signs (pain, etc.) are well marked, it may be also necessary to administer such drugs as antimony, aconite, full doses of acetate of ammonia, colchicum or ipecacuanha, to reduce the general blood-pressure, as also to obtain diaphoretic action. In a few cases, e.g., acute meningitis, venesection may be needed, and it is possible that this is an agent too little employed in the present day. In some forms of inflam- mation due to the specific diatheses, suitable drugs must be employed to combat such tendencies — e.g., salicylate of soda or salicin in acute rheumatism. In inflammation of infective origin serotherapy (p. 14) may be found of use, but at present the only diseases that are much affected by this means are diphtheria, tetanus, and erysipelas. (See on Erysipelas and Tetanus.) Chronic Inflammation. The phenomena of chronic inflammation are essentially the same as those of the acute process, though the manifestations are 38 A MANUAL OF SURGERY somewhat different. Hyperemia and exudation occur, but the tissue reaction is much more prominent. The main differences between the two are as follows : i. The hyperaemia is less in amount, but longer in duration, owing to the fact that the causative irritant is less intense in action, although often applied for a longer time. The local manifesta- tions therefore are less obvious ; pain is not so great and mainly of an aching character, whilst there is less heat, the redness is more dusky, and the tissues often become pigmented. Consider- able loss of tone in the vessels, especially the veins, results from the prolonged distension, and thus there is a greater difficulty in restoring them to a normal state. 2. The corpuscles do not adhere together or run into rouleaux to the same extent as in acute inflammation, and migration, though it exists, is on a limited scale. The exudation is more fluid in character, containing comparatively little albumen or fibrin ; in fact, in some chronic inflammations of serous mem- branes the cavities are distended with fluid of a much lower specific gravity than that of blood serum. 3. The greatest difference in the acute and chronic processes lies in the reaction of the tissues. In the former they are in a depressed or paralysed condition, but in the latter they become infiltrated with round cells, derived rather from the connective- tissue elements than from the leucocytes, and hence organization is much more marked than in the acute form. Tissue destruc- tion, consequently, is less prominent in the early stage of chronic inflammations, although as a secondary change, especially in tuberculous and syphilitic diseases, it is often seen. The Causes are similar in character to those producing the acute mischief, but slighter and more prolonged in their action. The most striking point in the aetiology is the large part played by diathetic conditions or constitutional predispositions. Most of the manifestations met with in surgical practice are due to syphilis, tubercle, gout or rheumatism, and one should never treat cases of this nature without carefully inquiring as to the possible existence of some such taint. The Results vary according to the part of the body affected, and also with the predisposing diathetic state, and we can here only indicate a few points worthy of notice. In Simple chronic inflammation the part becomes infiltrated and enlarged, mainly from proliferation of the connective tissues, and if allowed to persist, this will result in fibrosis or sclerosis. Thus, a bone is thickened and condensed in chronic osteitis {osteosclerosis), whilst in chronic periostitis a new subperiosteal formation of bone may occur. Glands become enlarged and indurated, mainly by hyperplasia of the connective tissue, whilst if the skin is involved it may either become hypertrophied and thickened, or entiiely loses its characteristic structure, being converted into granulation INFLAMMATION 39 or fibro-cicatricial tissue, with or without an intervening ulcera- tive stage. True suppuration rarely occurs, although certain organisms of low virulence occasionally lead to its development. In chronic Tuberculous inflammation the affected part is occu- pied by pulpy oedematous granulation tissue, scattered through which are definite tubercles, which may run together and lead to the formation of caseating foci ; these in turn may either result in suppuration or ulceration, or may undergo calcification, and their extension be limited by a sclerosing process around them. A diffuse overgrowth forms the earliest stage, and this is often followed by destruction of the involved tissues, and possibly dis- organization of the parts, with or without suppuration. In chronic Syphilitic inflammation (tertiary) the most marked feature is an invasion of any of the connective tissues by a fibro- cellular exudation and hyperplasia, which may be diffuse or localized ; if the former, general sclerosis of the part results, e.g., in the stony-hard tertiary testicle ; in the latter, a gumma is developed, which, owing to its want of blood vessels, usually undergoes central degeneration and bursts, giving exit to a gummy fluid, and perhaps leaving a leathery-looking slough be- hind. In all these varieties of chronic inflammation a marked pro- liferation is always found in the tunica intima of the arteries of the inflamed area, the result of an associated chronic endarteritis. Constitutional symptoms are but little evident, beyond those dependent on the diathetic condition to which the local phenomena are due, or to septic changes developed secondarily. The Treatment of chronic inflammation is usually more pro- longed and difficult tha.n that of acute cases, because of the con- stitutional dyscrasia which exists so frequently behind it. i . The cause must be removed whenever possible. Dead or diseased bone must be removed, and tuberculous material got rid of, by the knife or sharp spoon, whilst it is often desirable to supplement this by subsequently swabbing the parts over with liquefied car- bolic acid. A chronic abscess increases the action of the original irritant through the tension engendered by its presence, and hence it should be dealt with as early as possible (p. 54). 2. Keep the part at rest. This is just as much an essential as in the treatment of acute inflammation. Joints should be immo- bilized ; the spine must have the weight taken from it by suitable appliances, or, better still, by maintaining the recumbent position ; secretory glands are not actively exercised, and the organs of sense are protected from irritation. 3. Counter-irritation is one of the most useful forms of treatment for chronic inflammatory conditions. It is applied in many different ways, according to the character of the disease and the part involved. Thus, friction with the hand, or with stimulating embrocations, produces a hyperaemic condition of the skin, and promotes local activity in the superficial parts which may react 4 o A MANUAL OF SURGERY beneficially on deeper structures. Scoffs dressing may be similarly employed ; it consists in wrapping up the part (e.g., a joint) in strips of lint covered with ung. hydrarg. co. (containing over 10 per cent, of camphor), and then encircling it firmly with soap plaster, spread preferably on chamois leather. Iodine paint is another useful application, whilst blisters are most valuable in suitable cases. The moxa, a wound produced by burning a spirituous solution of saltpetre on the skin ; the issue, the mainte- nance of a raw surface, however produced, by the constant presence of some irritant, such as the insertion of a bead, or the use of savin ointment as a dressing ; and the seton, a double thread knotted at each end, passed for some distance under the skin, and drawn from end to end daily— all these are but little used now, although they might be occasionally employed with advantage. The actual cautery is the most severe form of counter-irritant, and is especially useful in some varieties of chronic inflammation of bones and joints. 4. Pressure is a most important element in the treatment of chronic inflammatory disorders, and probably acts by artificially bracing up vessels which have become relaxed and atonic from the prolonged distension to which they have been subjected. It also favours the absorption of inflammatory exudations. Firm bandaging, and especially the use of an elastic support, are the most satisfactory methods of application. 5. A most valuable means of treating chronic inflammations, and indeed many other affections, consists in Massage. It is impossible in a text-book of this size to give a full account of the methods employed, but we may state that the chief of them are known as effleurage, petrissage, and tapotement. Effleurage con- sists in plain up and down rubbing of the limb with the flat of the hand, the up stroke being always firmer than the down, so as to assist in the return of the blood and lymph from the part. In this way the circulation is quickened, and the vital activities of the tissues are increased. The skin should be lubricated with oil, vaseline, or some stimulating embrocation, and the rubbing, at first light, so as only to affect the skin and subcutaneous tissues, should gradually become firmer so as to influence the deep structures. Petrissage consists in kneading the muscles or other tissues between the finger-tips and the palm of the hand ; this necessarily should be done across the muscle fibres, working from below upwards, and is especially valuable in hastening the absorption of exuda- tions. In Tapotement a series of blows perpendicular to the surface is rapidly delivered by the ulnar side of the open or clenched hand; the circulation in the parts thus struck is much quickened, and when skilfully done no pain should be caused. 6. General or constitutional treatment must be adopted to meet the specific diatheses which are commonly associated with chronic inflammation, e.g., mercury or iodide of potash in syphilis. CHAPTER III. SUPPURATION AND ABSCESS. When the inflammatory process results from the action of certain micro-organisms, known as pyogenic, liquefaction of the inflamed tissue and of the exudation follows, the liquefied material being known as pus, and the process which leads to its formation as suppuration. Any localized collection of pus is known as an abscess, and of such two chief varieties are described — the acute and the chronic. Sometimes the pyogenic infection involves the cellular tissue to a considerable extent, and the pus is widely diffused through the substance of the limb or part ; such a con- dition is usually known as cellulitis (p. 90). Acute Abscess. Etiology. — A large amount of experimental work has been undertaken to ascertain the relations of bacteria to acute sup- puration, and from the mass of evidence — mainly concordant, but occasionally conflicting — the following conclusions may be drawn : (a) That bacteria are present in all acute abscesses, either in the pus, or in the abscess wall, or in both. Ogston of Aberdeen was the first to proclaim this fact, and it is now generally accepted. In some chronic abscesses, notably in the liver, the pus is occasionally found to be sterile ; this is probably due partly to the organisms having died, owing to their low vitality, and partly to the activity of the surrounding tissues, which has led to the encapsulation of the focus. (b) That such bacteria can reach the inflamed area either from without the body or from within. The former method is the more common, and is illustrated by the observations of Garre and Bockhardt, who rubbed cultures of Staphylococcus pyogenes aureus into the skin of their arms, and produced acute suppuration commencing in superficial pustules, and finishing as boils or carbuncles. Suppuration in wounds is most commonly due to infection from without, but there can be no question that auto- 42 A MANUAL OF SURGERY infection occurs, by means of which an abscess can be produced by infection from within the body. This can only happen when the vitality of the patient is considerably depressed, and some local condition exists favourable to bacterial development. Thus, given a blood-clot or inflammatory serous exudation in an unhealthy indi- vidual, whose germicidal power is low, suppuration can ensue from auto-infection, the organisms being carried by the blood to the affected area ; an abscess thus produced is termed an idiopathic infective abscess. Occasionally the microbes are carried either en masse (zooglcca condition), or in the substance of a small portion of blood-clot, as an embolus, from one part of the body where an infected wound or injury exists to some other part, thus originating an embolic infective abscess. Pyaemic abscesses are of this type, and similar results occur after gonorrhoea, and after typhoid and other fevers. (c) That ordinary irritating c/iemical products or sterilized foreign bodies (e.g., silver- wire or glass splinters) do not produce suppuration, except in the rarest of cases, by auto-infection. Thus, a ragged splinter of glass, an inch and a quarter long, and an inch and a half wide, the result of the bursting of a soda-water bottle, was cut out of the neck of a hotel porter ten months after it had entered ; it had caused no suppuration. Experiments, moreover, have been made with sterilized croton-oil and other irritants, in which the substance securely sealed up in a thin glass capsule is implanted amongst the spinal muscles of an animal, and after a delay to allow the thorough healing of the wound is set free by a blow. A collection of putty-like fibrinous material is found at the site of operation, and much discussion has arisen as to whether or not this is to be looked on as true pus. On the other hand, injections of metallic mercury, or of the ptomaines produced by bacteria (e.g., cadaverin, putrescin, etc.) certainly result in suppuration. In conclusion, therefore, although we have to admit that suppuration may be experimentally induced in animals in the absence of micro-organisms, in man for all ordinary conditions sup- puration does not occur apart from the presence and vital activity of specific bacteria. The causes of an acute abscess may for practical purposes be grouped under the three following headings: (i) The individual affected is possibly in a depressed and unhealthy state, and the germicidal properties of his tissues may be defective. (2) A local nidus must exist, which is in a condition of lowered vitality, from injury, cold or otherwise ; and (3) this spot must become infected with pyogenic organisms brought to it either from within or without the body. Bacteriology. — As already stated, the pus of all acute abscesses contains living organisms, the nature of which, however, varies with circumstances. When suppuration occurs in wounds in which there is but little putrescible material, or arises idiopathically, it almost always results from direct in- SUPPURATION AND ABSCESS 43 fection with one or more of the pus-producing pathogenic bacteria. In many so-called septic wounds, however, non-pathogenic bacteria are also present, leading to putrefaction of the discharge. The most important Pyogenic Organisms are as follows : i. Staphylococcus pyogenes aureus is that commonly found in all foci of localized suppuration (Fig. 3). It can readily be cultivated on nutrient gelatine, agar-agar, or blood serum. On plate cultures it forms in two days golden-yellow colonies, as also in tube preparations. It is very resistant to chemical and thermal reagents, requiring several minutes' boiling to ensure its destruction. It produces no gas and no stinking odour in its growth, and is capable both of peptonizing albumen and of liquefying gelatine. It is a facultative anaerobe (p. 4 ). 2. Staphylococcus pyogenes albus. 3. Staphylococcus pyogenes citreus. These two forms are mainly distinguished from the former by the colour of the colonies formed in their growth ; all their other properties are the same except that perhaps the citreus is a little slower in rendering gelatine fluid. t*SP B . i ■: V,t ' 1:1 2* t Tig. 3. — Staphylococci in Pus. (From Crookshank's ' Textbook of Bacteriology.') Fig. 4. — Streptococci in Pus. (Re- duced from Crookshank's ' Text- book of Bacteriology.') whilst the albus is apparently not so virulent. The latter organism is very similar to, if not identical with, the Staph, epidermidis albus, which is widely scattered over the skin, and is usually found in the small abscesses developing in connection with tense stitches. The staphylococci are mainly associated with the formation of localized abscesses. Thus, if a culture is rubbed into the skin of the forearm, a plentiful crop of boils, or perhaps a carbuncle, will result ; if injected beneath the skin, a subcutaneous abscess may be formed, or even a typical carbuncle, if a sufficient number has been introduced, and if they are unfiltered so as to retain their toxins; if the peritoneal cavity is infected, suppurative peritonitis follows, provided that a sufficient quantity of the organisms is present ; if a joint, suppurative arthritis. When injected into the blood-stream, there is but little effect if only a few are introduced ; but when many, multiple abscesses in any and every part of the body may occur, as in pyaemia, or more frequently true septicaemia ; if, soon after the injection of an amount not large enough to produce general infection, a bone or joint is injured, acute infective osteomyelitis or arthritis will follow ; whilst if the cardiac valves are arti- ficially damaged, a typical ulcerative endocarditis ensues. All these con- ditions can be produced artificially in animals, and, from the similarity of the symptoms and the microscopical appearance of the parts, we conclude that similar affections in man are due to exactly the same causes, except that the 44 A MANUAL OF SURGERY infection is not artificial, but comes either from without, as a result of local injury, or from the blood-stream. 4. Streptococcus pyogenes (Fig. 4 ) is an organism of great importance in path- ology, and it is the main exciting cause of many inflammatory conditions. It is probable that there are several distinct species included under this title- indeed, it is claimed that six different forms have been isolated; further researches are, however, needed to make certain of this fact. It can be readily cultivated on most nutrient media, but grows slowly at the ordinary tempera- ture of the air, and not very rapidly even at blood heat. It does not liquefy gelatine nor produce any colouring reagent, and does not form any proteolytic ferment. It occurs in chains of varying length, which may occasionally bifurcate. The Streptococcus pyogenes is mainly associated with spreading inflammations of the cellulitic type, whilst it is a common cause of pyaemia, and even of acute septicaemia. It has also been found in many acute localized abscesses, in empyema, and in some forms of suppurative arthritis. It is probable that the streptococcus of erysipelas should be included in this group. 5. The Bacillus coli communis is an organism to which much attention has been directed of recent years. It is identical with the microbes formerly known as the Bac. pyog. fcetidus and the Bac. lactis aerogenes. It exists normally in the intestinal canal, extending from mouth to anus, but most frequently in the duodenum and colon, and probably plays a considerable part in the normal process of disintegration of food-stuffs. So long as it remains within the bowel, it is perfectly innocent; but as soon as it is able to pass into or through the intestinal wall, as a result of any loss or diminution in its vitality or abrasion of its surface, it is liable to become intensely virulent, producing suppurative inflammation of the most acute type, or even necrosis. Hence it is the most common cause of acute suppurative peritonitis in all cases where the infection arises from within the bowel, whilst it is mainly responsible for the formation of abscesses in the neighbourhood of the tube, as in appendi- citis, acute ischio-rectal suppuration, etc. One of its most characteristic features is that — even when cultivated in a test-tube — it produces a most offensive and penetrating odour, somewhat similar to that of decomposing fasces; such is also noticed in the pus produced by the organism. It is also the most constant organism found in the bladder in cases of cystitis, but has no power of rendering the urine alkaline. 6. The Bacillus pyocyaneus is occasionally met with in wounds, producing what is described as blue or green pus. It is of little clinical importance, except that in a few cases it has been known to give rise to general infection. 7. The Pneumococcus and Bacillus typhosus may also give rise to suppuration after pneumonia and typhoid fever respectively, but they are not specially virulent, and the abscesses are usually of a subacute type. 8. The Gonococcus must also be included in this category. Pathological Anatomy of an Abscess. — The phenomena associ- ated with the formation of an acute abscess are merely a further stage of those detailed previously as characteristic of inflamma- tion. The vessels of the affected area become distended, and the various elements of the blood pass through the walls. As the organisms develop, the vascular phenomena of retardation and stasis followed by thrombosis occur successively, whilst the exuda- tion of cells becomes so great that the original tissue of the part disappears, after passing through a stage of coagulation-necrosis (Plate II., Fig. 1). This removal of the infiltrated tissues, though due in part to the defective blood-supply resulting from the pressure of the exudation and the vascular thrombosis, is largely ^3 H be be u t CD 3 C c II) .3 .3 be CD C* be c ^S J£ x 1 S 2 en T3 P H ./ ■" bo^ 3 j; <** c M '§*•£ •x "C 3 C d CD 1 .Sf 5 — E "O fe •S ^ J-3 d m U Cd 2* CD en 3 u *H si- E-S = M fce^ c a. a ^ > rt 1-1 '-> ■3 s^ E be ' u be -3 ^ ~ -p ,3 6 •„ (U-S m — x J-< '7} fa d Oh 0) ,3 u s = x o»6 X ~ o - Cfl ^ O -71 ^ tn O d f) 4) ° ^ be it > c - c u - -- N 8 ° 5 a; bo/" o.S'g d d en .2 .5 '53 55 53 O O _; ■- .- s d ~ n - • X — — — 1. - x C £ ~ w- X — d E CD X - J ' JZ - '£? CD C y CD X CD c 3 -= B E 4h U x 1) ." 3 X d CD j-, jD c r _ I d g d E 53 > d 53 be d ~z d ,3 c - c/l "" _o °T3 |H be 7 C d I SUPPURATION AND ABSCESS 45 caused by their liquefaction owing to the peptonizing power of the bacteria present. In streptococcal infections where a proteo- lytic ferment is absent, the solution of the tissues is probably brought about by the direct action of the many phagocytes present in the effusion, a process favoured by the damaged and degenerative condition of the cells of the part ; this absence of a ferment may explain why the onset of suppuration is sometimes slow. The inflamed focus, therefore, consists merely of an irregularly shaped mass of round cells, the central portion of which liquefies and breaks down into pus. When once this has commenced to form, it depends entirely upon the character of the irritant, and the nature and behaviour of the surrounding tissues, as to what will subsequently supervene ; but there is usually a tendency for the pus to increase steadily in amount. It may then find its way to the surface and point ; it may burrow along fascial or muscular planes ; or it may, somewhat less frequently, become circum- scribed, and more or less chronic. As soon as the acute or extending process comes to an end, repair begins to manifest itself in the vascularization of the embryonic tissue, and its trans- formation into granulation tissue. Should the abscess point, the normal tissues in the line it travels along are in their turn trans- formed into embryonic tissue, which becomes liquefied as soon as it is formed, whilst granulations spring up from the floor and sides of the cavity, endeavouring, as it were, to obliterate the track the abscess has followed. Thus, a definite distinction must be drawn between the structure of its wall in the early and late stages, which, however, we often see co-existing in the same abscess. In the former or early stage of tissue destruction (Plate II., Fig. 1), the following zones are met with in passing from the centre to the periphery : (1) The central collection of pus ; (2) a layer of breaking-down embryonic tissue infiltrated with bacteria ; (3) em- bryonic tissue showing a trace of the original structure of the part in a state of coagulation-necrosis, with the vessels thrombosed and many bacteria present ; (4) tissue of the part infiltrated with leuco- cytes and organisms, and with the blood-stream either stopped completely or retarded ; (5) hyperaemic and slightly infiltrated tissue of the part, gradually shelving off into normal tissue. It must be clearly remembered, however, that the inflammatory focus is at first diffuse, and that the zones indicated here are quite artificial. The early abscess cavity is extremely irregular in outline, and the lining wall very variable in character, one part being possibly thick, and another quite thin and yielding readily to the extension of the proces. In the later stages (Plate II., Fig. 2), where the inflammation is not spreading, the structure of the abscess may be thus described: (1) The central focus of pus ; (2) a layer of granulation tissue to a large extent free from bacteria ; (3) a layer of fibro-cicatricial tissue gradually merging into (4) the normal tissue, somewhat infiltrated and hyperaemic. 46 A MANUAL OF SURGERY The Clinical Signs and Symptoms of an acute subcutaneous abscess may be arranged under three headings : i. The local signs consist of a patch of inflamed tissue, indicated by heat, pain, redness and swelling, which latter is at first hard and brawny, but when pus forms the centre becomes soft, elastic, and fluctuating, whilst superficial oedema is more marked, and the pain throbbing in character. Naturally, the amount of this pain depends entirely upon the density of the tissue affected and the supply of sensory nerves to the part, suppuration beneath a resisting membrane, such as the palmar fascia, being always intensely painful. If left to itself, an abscess sooner or later points and bursts. As it increases in size, it exerts pressure in all directions, and naturally seeks to find an exit in the line of least resistance, and so may either find its way to the surface, or may burrow along muscular and fascial planes, or into adjacent cavities. This is not merely a mechanical, but also a vital process, as already described. The actual bursting of an abscess is often due to some injury — it may be a slight one — but is usually pre- ceded by ulceration of the integument, or perhaps, if the abscess is a large one, by necrosis. 2. Pressure effects are mainly due to the mechanical influence of the swelling upon surrounding structures. The most evident are those due to the irritation of nerves, as a result of which neuralgic pain may be present, or the patient may refer the pain to some distant unaffected region. In some cases, where bloodvessels are involved, the tissue around them disappears, and they are left in the abscess cavity as bands, surrounded by granulation tissue. Thrombosis and the subsequent obliteration of the vessel may result, or occasionally ulceration and haemorrhage (ulcerative periarteritis), preceded perhaps by an aneurismal dilatation of the vessel, owing to its loss of external support. Such effects are more common in chronic than in acute abscesses. 3. The general effects of the formation of an acute abscess are those of increased fever, sometimes amounting to a rigor, and leucocytosis. A rigor consists of a definite series of phenomena, the result of some stimulating influence reaching the thermogenic centres of the medulla, and determining a sudden increase of activity. It is very similar in nature to an attack of ague, being ushered in by a feeling of intense cold and discomfort ; the features are pinched, and the teeth chatter. The skin, however, feels dry and hot, and the temperature of the body rapidly rises. The sensation of cold is partly due to the contact of air at a main- tained normal temperature with the hot, dry, unperspiring skin, and also possibly to the condition of superficial anaemia which is present. After this stage has lasted a variable period, the patient gradually begins to feel warmer, the face becoming flushed, the thermometer ceasing to rise, and the skin com- mencing to act. Finally there is a rapid fall of temperature SUPPURATION AND ABSCESS 47 accompanied by profuse perspiration, which leaves the patient more or less exhausted. Leucocytosis is the term employed to indicate an increase in the number of white corpuscles in the blood. Normally about 8,000 leucocytes are found in each c.mm., although the number is some- what increased immediately after meals. When suppuration is occurring, the proportion may be enormously increased, even up to 100,000 per c.mm. It is best seen in cases of severe infection, well resisted, and is not a very obvious feature when the infec- tion is so acute as to break down all resistance, or so slight as to cause little constitutional disturbance. A blood-count may be advisably undertaken in some cases of doubtful diagnosis. Pus and its Constituents. — Normal, or as it was formerly called healthy, or laudable pus is a thick, creamy fluid, having a specific gravity of about 1030, an alkaline reaction, no smell (unless putre- fying or under special circumstances), and containing 85 to go per cent, of water. If allowed to settle, it separates into two layers, the upper or fluid part, liquor puris, consisting of liquefied tissue and serum, and containing about 6-7 per cent, of proteid material (i.e., rather less than in normal blood serum) ; whilst the lower layer includes the solid elements present, viz., dead and living pus corpuscles, fatty and granular debris, perhaps micro-organisms, and possibly a few red blood cells. All the pus cells look alike when examined under the microscope on a cold slide ; but if placed on a warm slide, a difference is soon noticed. Dead pus cells are rounded in outline, about 0500 inch in diameter, coarsely granular in texture, and show two or three nuclei, which become more evident on the addition of dilute acetic acid. The living pus corpuscles are fewer in number, and, though spherical at first, soon manifest amoeboid movements ; their protoplasm is finely granular, and the single nucleus is not readily observed ; the proliferation of the nucleus is always an evidence of degenera- tion and approaching death. It must be clearly understood that both the living and dead cells are derived from the same sources, viz., principally from the extravasated leucocytes, but also possibly from proliferation of the fixed connective-tissue corpuscles of the part. As already stated, the pus in an acute abscess contains bacteria, which are best demonstrated in the following way : A drop of pus is placed between two cover-slips, which are each evenly coated by a thin layer of the fluid by sliding one over the other. These are dried by passing them through the flame of a spii it-lamp, only sufficient heat being employed to set the albumen without destroying the corpuscles. A drop of methyl-violet solution is now placed over the pus film, and allowed to remain for about a minute, being then washed away by a stream of distilled water. The slip should be again dried slowly, and mounted in Cana.da balsam. The cocci will be found stained deeply, whilst albuminous and fatty granules are not coloured at all, or but slightly (Figs. 4 and 5). When pus is mixed with blood, it is termed saDious (short for 4 8 A MANUAL OF SURGERY sanguineous) ; when thin and acrid, it is ichorous ; curdy, when mixed with curdy shreds, as is more usually seen in chronic suppuration of a tuberculous nature ; muco-pus, when mixed with mucous, arising from inflammatory conditions of mucous mem- branes. The occurrence of stinking pus apart from putrefaction has been already explained as generally due to the activity of the Bacillus coli communis. Occasionally an abscess is found to contain not only pus, but also gas. This may be due to the existence of a direct com- munication with some hollow viscus — e.g., the stomach or intestine — and hence is met with in subphrenic abscess and in some of the many types of abscess associated with appendicitis ; but it is sometimes the result of infection with a gas-producing organism — e.g., the Bacillus arogenes capsulatus or Bacillus cedematis maligni. This latter type is rare apart from spreading gangrene ; but we recently opened a perineal abscess in a diabetic patient from out of which the gas literally whistled, whilst in a few days emphysema had spread over the whole trunk, in spite of incisions to limit its progress. Very extensive sloughing followed, and the patient died. The Bacillus adematis maligni was isolated in this case. The Diagnosis of an acute superficial abscess usually presents no difficulties, the sense of fluctuation supervening in the midst of an area previously inflamed and brawny being quite charac- teristic ; sometimes, however, all that can be detected is a feeling of elastic resistance in the centre of the hyperaemic indurated focus, but this, to the practised finger, is quite as conclusive of the presence of fluid as fluctuation. When the pus is placed deeply under muscular and fascial planes, very careful examina- tion may be needed in order to determine its presence ; the surgeon must not be misled by the sense of fluctuation obtained across the fibres of a muscle ; none is noticed, however, by pal- pating along the course of its fibres. Treatment of Acute Abscess. — When an inflamed area is threatening to suppurate, the formation of pus can be but rarely prevented. In the early stages, elevation and rest of the part, together with the application of cold and evaporating lotions, may sometimes succeed in accomplishing this, together with the administration of quinine and iron. The hypodermic injection of powerful antiseptics — e.g., pure carbolic acid — has also been employed to destroy the pyogenic organisms in situ, whilst in some cases (e.g., in acute periostitis) a free incision through the inflamed tissues is permissible. In a few regions of the body, pus may be absorbed after its formation, but only when situated in a cavity of highly-absorbing powers, such as the anterior chamber of the eye (hypopyon), or perhaps some of the serous cavities, e.g., the peritoneal. In the former the process of absorption may certainly be observed under the influence of local and general treatment. SUPPURATION AND ABSCESS 49 As a rule, however, one encourages suppuration by applying fomentations or poultices to the part, and then as soon as pus is evident, an incision is made to evacuate the abscess cavity. The opening must be large enough to prevent re-accumulation ; it should be placed at a spot suitable for drainage, but as far as possible from sources of septic contamination, and in such a direction that movements of the part do not close it. In dealing with deep abscesses in dangerous regions, Hilton s method may be advantageously employed. It consists in merely dividing the skin and superficial structures, and then thrusting a director into the abscess cavity ; a pair of sinus or dressing forceps is now passed along the groove, and on forcibly separating the blades a sufficient opening is made to insert the finger, and subsequently a drainage-tube. Methods of Opening Various Abscesses. — Axillary Abscess. — Cut in the median line of the axilla towards the chest from above downwards, and use Hilton's method, thus escaping the three main sources of danger, viz., the axillary vessels above, the long thoracic in front, and the subscapular vessels behind. Inguinal Bubo. — Make a vertical incision from below upwards, the patient standing erect against a wall or lying down. When he sits the incision gapes, and so accumulation is prevented. Intramammary Abscess. — Cut in a direction radiating from the nipple to prevent injury to the galactophorous ducts, and pass a finger in so as to open up all the dilated lobules. Submammary Abscess. — Open along the lower margin of the breast, and, if possible, towards the outer side, carefully avoiding the glandular tissue. Retropharyngeal Abscess. — Incise along the posterior border of the sterno- mastoid for about an inch ; draw that muscle and the carotid sheath forwards ; open by Hilton's method, pushing a director inwards to the middle line immediately in front of the transverse processes Ischio-rectal Abscess. — Place the patient leaning over the back of a chair, or in the lithotomy position if an anaesthetic is employed, and incise vertically and very freely, as far from the anus as possible ; healing may ensue without opening the rectum. In some cases where the skin is undermined, a crucial incision should be made, the resulting corners of skin being removed. In opening a Palmar Abscess, care must be taken not to wound the super- ficial palmar arch or its digital branches. It is best accomplished by entering the knife immediately in a line with the centre of the metacarpal bones, cutting forwards to the base of the finger ; the upper limit of this incision should not transgress the centre of the palm. A Whitlow should be opened in the middle line of the finger by a knife held with its back towards the wrist, and it often happens that the patient, if conscious, unwittingly assists at his own operation by withdrawing his hand, thus effectually completing the incision ; care must, of course, be taken hot to let the knife travel too far or too deeply. It is advisable to gently squeeze an abscess after opening it, especially if sloughs are present, or when it has burrowed ; if the cavity is large, it should be explored with the finger. All that is subsequently needed, if there is no complication, such as the presence of dead or diseased bone, is to arrange for drainage, as by inserting a drainage-tube or a slip of protective, and to exclude sepsis by a carefully applied antiseptic dressing ; in other cases 4 50 A MANUAL OF SURGERY it may be desirable to pack the cavity with gauze soaked in an iodoform emulsion (10 per cent.). There is often a considerable loss of blood during the first twenty-four hours from the yielding of the capillaries in the abscess wall, owing to the sudden relief of tension ; but this usually ceases of itself, or yields to moderate pressure. When once the abscess has been evacuated, no move pus is formed if the cavity is kept aseptic, the discharge being merely serous, and the wound rapidly closing and healing. Our colleague, Mr. G. L. Cheatle, has pointed out that, although no more pus is formed, the cavity and its lining wall still contain bacteria, and perhaps in a state of virulence, but they are evidently unable to develop or do any harm, possibly from the tissues being immunized or protected against them. Pus which stinks on its escape loses all smell in a day or two, the wound pursuing a normal course, unless the abscess communicates directly with the bowel. In some cases the original opening at the spot where the abscess pointed may not give efficient drainage ; a counter-opening should then be made by pushing the finger, or a probe, through the abscess wall amongst the tissues, making it protrude beneath the skin at some dependent spot, and cutting down upon the finger or probe in this direction. Chronic Abscess (syn. : Cold or Congestive Abscess). A chronic abscess may be defined as a collection of pus which forms slowly without any signs of active inflammation. Although a few cases are due to infection with pyogenic microbes or to chronic pyaemia, yet the vast majority are tuberculous in origin ; and, indeed, when a chronic abscess is spoken of, it may be taken for granted that it is tuberculous, unless otherwise stated. It must be clearly understood that, although we speak clinically of a chronic tuberculous abscess, it is a question whether the term is correct, and whether the fluid contained therein is pus ; certainly its method of origin and characters are very different to those of an acute abscess. For the present, however, it is convenient to retain the terms ' pus ' and ' abscess ' in this con- nection. Wherever tubercle can be deposited, a chronic abscess may form ; but it occurs most commonly in connection with bones, joints, and lymphatic glands. Into the details of these causative affections it is unnecessary to enter here ; suffice it to state that the abscess arises from the degeneration and liquefaction of a tuberculous focus ; that it forms a soft fluctuating swelling, gradually increasing in size, and possibly by its pressure effects becoming painful ; that it may come directly to the surface if there is no dense fascia to prevent it, but that, being often placed deeply, there is a great tendency to burrow along fascial planes, and hence to become superficial at a spot far removed from its original source. Thus, an abscess arising in connection with tuberculous disease of the dorsi-lumbar region of the spine may SUPPURATION AND ABSCESS 51 travel in many directions : it may pass backwards, and be opened at the side of the spine as a lumbar abscess ; it may infiltrate the superficial fibres of the psoas muscle, and travel down the sheath to the groin, pointing either above or below Poupart's ligament (Fig. 5) ; or it may find its way into the pelvis and escape by the side of the rectum. The far-reaching extent of these abscesses, the impossibility of dealing adequately with the lining membrane, together with the infective nature of the disease and the often inaccessible position of the original focus of the mischief, render them most difficult to treat, and fully account for the dread of opening them experienced by surgeons in pre-antiseptic days ; for should the cavity of the abscess once become septic, there is but little hope of again purifying it, and the result is an increased discharge of pus, absorption of the chemical products of putrefac- tion, aggravation of the original disease, and only too frequently death from exhaustion or blood-poisoning. The pus contained in a chronic abscess may be of the ordinary type, consisting of cells and bacteria ; but if of tuberculous origin, there are only a few cells, and those in a condition of fatty degeneration, whilst masses of curdy debris of variable size and consistency are often present, if the abscess is of long standing, an abundance of cholesterine crystals is often seen, a fact re- cognised by the naked eye by the glistening sheen or greasy appear- ance imparted to the pus ; micro- scopically, they appear in the shape of rhomboidal plates, with one corner notched out. It is unusual to find either cocci or bacilli in the pus of a chronic tuberculous abscess, and this in spite of the fact that inoculation of animals with the pus results in tuberculosis. Probably the bacilli have been broken up by the sup- purative process, but the more resistant spores are still present. The microscopic appearance of a tuberculous abscess wall is quite characteristic (Plate III., Fig. 2). The method of extension along the The Cavit y I s lined b Y a la y er of psoas tendon and into the thigh g ra y» yellowish-gray, or pinkish, is well seen. pulpy granulation tissue, contain- ing miliary tubercles perhaps undergoing caseation. Its colour and vitality are dependent upon the chronicity or not of the process ; the longer the abscess is in DUE TO Fig. 5. — Psoas Abscess Disease of the Upper Lumbar Vertebrae. (After Albert.) 52 A MANUAL OF SURGERY forming, the less vascular the membrane, owing to the associated sclerosis of the surrounding structures leading to compression of the bloodvessels, whilst it has been already mentioned that endar- teritis always accompanies a chronic inflammation, and helps to render the parts non-vascular. This lining membrane, when necrotic, is but loosely connected with a layer of fibro-cicatricial material, which forms the outer part of the wall, and from which it can often be readily detached by the finger or a sharp spoon. This, in turn, gradually shelves off into the normal tissue which surrounds the abscess. In non-tuberculous cases the lining wall consists of granulation tissue passing over into the normal structure of the part, which is more or less sclerosed, according to the duration of the mischief. Natural Cure. — A tuberculous abscess, if left to itself, does not necessarily come to the surface and burst. Occasionally in the dead-house one meets with a mass of putty-like consistency lying in front of the spine in the body of a patient who has been cured of spinal disease. This is evidently the desiccated remains of a chronic abscess, the fluid portion having been absorbed, and the solid elements left behind, encapsuled and perhaps infiltrated with lime salts. Such debris can become the seat of recurrent inflam- matory mischief when the original disease has been quiescent for years ; suppuration may suddenly occur, giving rise to what is known as a residual abscess. Probably a large amount of choles- terine will be found amongst its contents. The prognosis of such an abscess is good ; in more than one instance we have cured them entirely by one tapping and free lavage. Results of Long- continued Suppuration. — When a chronic abscess is emptied antiseptically, and maintained in an aseptic condition, the formation of pus ceases ; the wound may remain open for months, but the discharge is merely serous, and no constitutional results will be manifested. The temperature is normal, and the general health unimpaired, if no other disease is present. Should such an abscess become septic, the condition of affairs is at once changed ; the discharge becomes profuse and purulent, fever supervenes, and grave visceral changes occur, which sooner or later may lead to the patient's death from exhaustion. Long-con- tinued suppuration, then, is always an evidence of sepsis, and from it two conditions may arise, viz., hectic fever and lardaceous disease. Hectic Fever may be defined as a chronic toxaemia or condition of blood-poisoning, due to the continual absorption of small doses of toxins, and is met with not only after opening chronic abscesses, but also in any condition of chronic sepsis, e.g., after acute or chronic suppurative affections of bones or joints, in tuberculous disease of the lungs, and in septic syphilitic or cancerous disease. It is characterized by a regular diurnal elevation of temperature, which runs a tolerably typical course. It commences to rise during the afternoon, the face becoming flushed (hectic flush of the cheeks), the eyes bright and sparkling, the pupils dilated, SUPPURATION AND ABSCESS 53 and the patient feeling better and stronger. The pulse, how ever, is small, compressible, and ten or twenty beats quicker than it should be ; the tongue becomes red at the edges and tip. This condition continues till late in the night, by which time the temperature may have risen four or five degrees. It then com- mences to fall as rapidly as it had formerly risen, and usually drops to the normal, or even below it, and in the early morning a profuse perspiration breaks out which soaks the patient's clothes, and leaves him in a much-exhausted condition. Day by day this ^ %':'%fm^-y c- Fig. 6. — Amyloid Kidney in Early Stage. (Ziegler.) (Treated with Miiller's fluid and perosmic acid, x 300.) a, Normal capillary loop; b, amyloid capillary loop; c, fatty epithelium of glomerulus; Cy fatty epithelium of capsule ; d, oil-drops on the capillary wall ; e, fatty epithelial cells in situ ; /, loosened fatty epithelial cells ; g, hyaline coagula (forming ' casts ') ; h, fatty cast in section ; i, amyloid artery; k, amyloid capillary ; I, infiltration of connective tissue with leucocytes ; m, round cells (leuco- cytes) within a uriniferous tubule. continues, the fever and sweating together causing a marked diminution in the patient's strength. Amyloid, Albumenoid, or Lardaceous Disease of various organs is also present in cases of long-standing suppuration. As to the cause of this curious condition, but little is known ; either from the deleterious effects of toxic compounds circulating in the blood, or from the loss of some special substance in the discharge, e.g., alkaline phosphates, the walls of the smaller arteries and 54 A MANUAL OF SURGERY the protoplasm of certain of the viscera are converted into or infiltrated with a waxy substance, from which lardacein, an extremely insoluble proteid body, may be obtained. The name ' amyloid ' is an entire misnomer, as this material is in no way akin to starch. It occurs as a waxy homogenous material, becoming a dirty brown on the application of tincture of iodine, and an inky blue when sulphuric acid is subsequently added. With methyl-violet the amyloid substance is coloured ruby-red, whilst normal tissues are stained blue or indigo. The organs mainly affected are the liver, spleen, kidneys, and villi of the intestines, and the capillaries and muscular coats of the arterioles (Fig. 6, b and i) are the parts first attacked, the change gradually spreading to the parenchyma of the organ. The liver becomes evenly enlarged to a considerable degree, often reaching from the fifth rib to the umbilicus, or lower ; it is firm in consistency, like indiarubber, painless, and waxy-looking on section. The arterioles and capillaries in the intermediate zone of the lobules are those first affected, but the cells soon participate in the change. The glycogenic and bile-producing functions are naturally interfered with, so that the digestive process, and especially the power of absorbing fats, is impeded. The kidneys become similarly enlarged, the change commencing in the arterioles leading to the glomeruli (Fig. 6), but the capillaries and the tubal epithelium are also early affected. In this stage the urine is very abundant (from the increased filtration through the degenerated walls), pale, limpid, and containing a few hyaline casts and fatty cells; later on, when the tubules are more largely involved, there is less urine, with a higher specific gravity, and a considerable amount of albumen. The spleen increases in size, but not always to so great an extent as the other viscera ; the Malpighian bodies are the chief seat of the mischief. The capillaries in the villi of the intestines become lardaceous, and allow of an increased transudation of the fluid parts of the blood, resulting in diarrhoea ; the absorption of nutriment is thereby much lessened, and thus both by increased excretion and diminished absorption of food the strength of the patient is steadily undermined. Amyloid changes in the viscera, far from being a contra-indica- tion to operation, are rather to be considered as a sign that radical treatment is urgently necessary, unless the general condition of a patient is such that he cannot stand the strain of it. If by an operation, e.g., excision or amputation, the local disease can be eradicated, the amyloid changes in the viscera may totally dis- appear. Treatment of Chronic Abscess. — In former days the rule always given was to leave a chronic abscess alone as long as possible, and never to interfere unless forced to do so ; sepsis, followed by hectic and increased rapidity of the disease, almost always resulted from such interference. But when asepsis can be maintained, SUPPURATION AND ABSCESS there is no reason to depart from the ordinary rule of surgery, that the abscess should be evacuated as soon as possible after its formation. It is, however, most important to recognise the fact that one slip in the technique may lead to a fatal issue, and therefore none should interfere with these cases unless they are prepared to take the time and trouble needed to keep them aseptic. Again, from the risk of sepsis being admitted during the dressing of the case, those methods should be preferred which admit of the immediate total closure of the wound. Many plans of treatment of chronic abscess have been suggested and practised ; we can here only allude to the more important. 1. Simple aspiration has been known to effect a cure, but only in excep- tional circumstances, viz., where the causative lesion is absolutely passive, and when the patient's health and constitution are vigorous. It often fails from the blocking of the aspirator needle by curdy debris, and there is always a fear that much of this material will be left behind, forming a possible source of future re-infection. The rapid emptying of the sac, moreover, often leads to haemorrhage, and the blood thus collecting will form a favourable soil for the development of the spores remaining in the curdy masses, or of the bacilli within the pyogenic membrane. 2. Tapping the abscess with thorough irrigation is another plan of treatment which under favourable circumstances is occasionally successful. We have seen a large psoas abscess cured by one thorough washing out. The modus operandi is as follows : The skin is incised, and through the opening a large trocar and cannula is inserted into the abscess cavity, which is emptied as completely as possible. It is now distended with a warm solution of carbolic acid (i in 80), or with a sublimate lotion (1 in 5,000), or simply with sterilized water or salt solution (5i. ad Oi.), at a temperature of 105 to 110° F. The abscess is then well kneaded with the fingers, and the fluid with the curdy- masses and broken-down pyogenic membrane is allowed to escape. The process is repeated again and again until the escaping fluid is nearly clear, or only slightly opalescent. The cannula is now withdrawn, the wound firmly stitched up, and an antiseptic dressing applied, using sufficient pressure to obliterate, if possible, the abscess cavity. The patient must be kept quiet, and carefully watched for a time, to ascertain if there is any reaccumulation, when the same process may be repeated. 3. Opening the abscess and scraping out the interior with Barker's flushing gouge combines the irrigation of the previous method with the more or less complete removal of the tubercle-containing pyogenic membrane. The instrument employed consists of a gouge or sharp spoon with a long hollow handle, which communicates by a tube with a reservoir of fluid placed at some height above the patient. During its application the constant rush of water or lotion through the handle clears the gouge, and removes the debris. It is admirably adapted for certain cases, but its use needs considerable care, as the sharp edge can readily scrape through an abscess wall, and do much mischief. It is a convenient means of dealing with abscesses of bones and joints in the more superficial parts of the body. The wounds should be subsequently closed, and an attempt made to gain immediate healing of the denuded cavity. 4. Injection of an antiseptic into the sac after tapping is a method introduced by Professor Velpeau in France, and has been received with much favour. Various reagents have been employed, but the majority contain iodine either in the form of the tincture, or as iodoform, which latter may be suspended in glycerine or olive-oil (10 per cent.), or dissolved in ether (5 per cent.). The method of introducing these compounds is quite simple, the amount varying, but as a rule not more than a drachm of iodoform should be used. When 56 A MANUAL OF SURGERY the ethereal solution is injected, the ether immediately volatilizes and hilly distends the abscess cavity, which becomes tense and tympanitic ; it must therefore never be used for abscesses communicating with the interior of the thorax, death having in one or two recorded cases resulted from heart failure, due to such distension. There is some danger, too, that serious toxic symptoms may arise from absorption of the iodoform. This treatment is most likely to be efficacious when all active bone or joint disease has dis- appeared, and is frequently employed as an adjunct to one of the above- described plans. 5. If the above methods fail, or are for any reason inapplicable, the original antiseptic method of simple incision with drainage can always be adopted. This is perfectly safe, so long as asepsis is maintained ; but the great objections to it are the length of time (months, or even years) often required to bring about healing, especially in cases where, although a free incision is made, the actual seat of the disease is not reached, and the risk of contamination during one of the repeated dressings that are required. 6. In certain cases of external chronic abscess, especially when connected with lymphatic glands, it may be possible to dissect out the whole cavity en masse, and if such is feasible, it is the most satisfactory plan to adopt. Should the posterior wall of the cavity be adherent to important deep structures, it should be thoroughly scraped so as to remove all pyogenic material, and disinfected, e.g., with liquefied carbolic acid or solution of zinc chloride (40 grains to 1 ounce). An attempt may then be made to gain healing by first intention, or the cavity may be stuffed and allowed to granulate. 7. Laying the cavity freely open, scraping away the pyogenic tissue, perhaps purifying with carbolic acid, plugging the wound firmly with gauze infiltrated with purified iodoform, and allowing it to granulate from the bottom, or the open method, may be used advantageously in cases where abscesses have burrowed between muscles, and along fascial planes. Sulphur has also been used instead of iodoform, but has no special advantage, whilst it causes a good deal of sloughing of the surrounding tissues owing to its transformation into sulphurous, and finally into sulphuric acid. Friar's balsam (1 part in 8 of castor oil or glycerine) may be employed in the same way, and is innocuous and useful. Sinus and Fistula. When an abscess has been opened, and does not completely heal, a communication often persists between the original seat of the disease and the exterior, which is known as a sinus or fistula. A Sinus is a narrow track lined with granulations, penetrating into the tissues, open at one end and closed at the other ; the dis- charge is purulent or merely serous according to whether or not sepsis is present. A Fistula is an abnormal communication be- tween two cavities, or between a cavity and the external surface. When such conditions result from the non-closure of a chronic abscess, the walls consist of exactly the same structures as those of the original abscess, viz., an external fibro-cicatricial vascular layer, merging into healthy tissues, and an internal lining of pyogenic membrane containing tubercles, if the origi- nating disease was tuberculous. If the fistulous track is short, there is a tendency for the granulating wall to become covered with epithelium, and under such circumstances it cannot be ex- pected to close until the epithelium has been removed, and a raw surface again exposed. SUPPURATION AND ABSCESS 57 It is often a matter of the greatest difficulty to secure the heal- ing of a sinus or fistula, and the following are the main causes of their non-closure : (1) The presence of some chronic irritant in the depths of the wound, such as a piece of the clothing, a catgut ligature, a piece of silver-wire used in an operation, or of some diseased tissue, such as a fragment of dead or carious bone : (2) the irritation of discharges finding an exit through the abnormal opening, such as urine, faeces, or foetid pus ; (3) in- sufficient drainage of a deep cavity, so that there is always a certain amount of tension in the wound ; (4) want of rest to the part, due either to voluntary movements, as in the limbs, or to involuntary muscular action in the immediate neighbourhood, as in fistula-in-ano ; (5) tuberculous infection of the wall, or a tuberculous deposit at the bottom of the sinus ; (6) the growth of epithelium down the sinus or round the margin of the fistula ; or (7) constitutional debility. The orifice of a sinus is often depressed from the amount of infiltration around, but in cases where foreign bodies are lodged within, or where diseased bone exists, it is usually surrounded by prominent fungating granulations. Treatment. — The removal of the cause is the first thing to accomplish in dealing with a sinus or fistula. The passage must be dilated or slit up to allow of access to the deeper parts of the wound, to remove any foreign body which may be present, or to allow of the satisfactory drainage of a deep cavity. The making of a dependent counter-opening often suffices to cure a sinus. A thorough purification of the part by pure carbolic acid or chloride of zinc must also be undertaken, and the wound dressed by plugging with suitable material and kept at rest, whilst the general health of the patient is improved by tonics. Occasionally, the pressure of a roller bandage to immobilize the part is all that is required, or the application of a suitable splint. The most complete and certain method is to lay the sinus open and thoroughly destroy the lining granulation tissue by scraping or cauterising, and then to plug the wound, allowing it to heal from the bottom by granulations. Should a fistula have become lined with epithelium, the edges will require paring, and some form of plastic operation must be undertaken to close the opening. The term ' fistula ' is also applied to conditions other than those tracks remaining from the non-closure of an abscess. Three classes may be described : 1. Congenital fistula, e.g., branchial, umbilical urinary or faecal, etc. 2. Traumatic fistula, e.g., aerial, pharyngeal, salivary, recto- vesical, recto-vaginal, etc. 3. Pathological fistula, or those secondary to abscess or disease, e.g., biliary, faecal, perineal urinary, fistula-in-ano, etc. Each of these will be referred to later on under its appropriate heading. CHAPTER IV. ULCERATION. Ulceration has been denned as the ' molecular or particulate death of a part,' by which is meant the disintegration of the super- ficial tissues, which liquefy and disappear, and usually without any obvious slough. It differs from gangrene in that the latter term is used to denote the simultaneous loss of vitality of a considerable portion of tissue. The two processes are, however, often closely associated — in fact, both signify tissue necrosis ; in the former the dead particles are not always visible to the naked eye, whereas in the latter the necrotic portions, if superficial, can always be seen. Three main classes of ulcers are met with in surgical practice : I. Ulcers due to traumatism or to the ordinary pyogenic bacteria, e.g., the spreading, healing, chronic, etc. II. Ulcers due to specific* bacteria, e.g., soft chancre, lupoid, tuberculous, syphilitic, etc. III. Malignant ulcers, e.g., rodent, epitheliomatous, scirrhous, and fungating. Causation. — Ulceration is due to the application of an irritant to the surface of such an intensity, and for such a period, as to lead to local inflammation resulting in the destruction of the tissue affected. Any form of irritant, whether chemical, thermal, mechanical, or infective, may accomplish this end, and all the factors predisposing to inflammation will hasten its occurrence. Thus, faulty nutrition, whether from anaemia or from long-standing congestion, is particularly liable to further the ulcerative process. Moreover, when any part becomes anaesthetic, or is cut off from its trophic centres, the continued presence of an irritant may not be appreciated, and hence destructive inflammation occurs, e.g. * It may be well to note that whilst the term infective is applied to any condition due to an invasion with bacteria, the word specific denotes that the lesion is due to one special or specific organism. Nearly all inflammatory ulcers are infective in nature, but only those in Group II. are specific; many different types of organisms may give rise to the ulcers in Group I. ULCER A TION 59 corneal ulcer following section of the fifth nerve, or perforating ulcer of the foot in tabes. In malignant disease the projection of the mass of the growth may expose it unduly to irritation ; but the chief cause of ulceration is the replacement of the deeper layers of the skin or mucous membrane by the cells of the neoplasm, so that when the superficial epithelium wears off or is lost, it cannot be reproduced. I. Ulcers due to Traumatism or to the ordinary Pyogenic Bacteria. Clinical History. — Every ulcer of this class tends sooner or later to recovery, and so may be said to pass through three stages, viz., (i) that of ulceration proper, or extension ; (2) a stage of transi- tion, or preparation for healing, which may be short or long, according to whether the ulcer is running a rapid or a slow course, and persists until the surface is covered with granulations; and (3) the stage of healing or repair. It must be clearly understood that the first stage alone represents the true ulcerative process ; when this ceases, the ulcer proper disappears, and merely a superficial loss of substance, the result of the preceding ulceration, remains. If every simple ulcer passes through these three stages, then every variety of simple ulcer must necessarily be in one of the three stages, and hence may be described as a modification of a typical condition representing the stage to which it belongs. Naturally, in a large ulcer the three stages may co-exist, or a healing ulcer may from intrinsic or extrinsic causes relapse again to the stage of tissue destruction. Stage I. : Ulceration proper or Extension. — The special charac- teristic of this stage is that destructive changes are progressing with greater or less rapidity, and hence the ulcers may be described as inflamed, spreading, or sloughing. Naked-eye Appearances. — Surface, covered with ashy gray or dirty yellow material, partly slough, partly lymph, partly breaking- down tissue ; no granulations are present ; the tendency to slough is most marked when the organisms are particularly virulent, or if the resistance of the tissues is much diminished ; discharge, considerable in amount, thin, sanious, and often irritating and offensive, rarely purulent ; margins, thickened and inflamed, and the surrounding tissues often cedematous and infiltrated ; edge, sharply cut and well defined ; the base of the ulcer is thickened and fixed to the underlying structures. Microscopically, all the phenomena of inflammation may be observed progressing to thrombosis and tissue necrosis, so that in approaching the surface from the healthy tissues one would pass through zones of active hypersemia, of retarded blood-flow with infiltration of leucocytes and plasma, of stasis and throm- bosis, whilst the tissues are in a state of coagulation-necrosis. 6o A MANUAL OF SURGE NY Treatment of First Stage. — This resolves itself into removing the cause, protecting the surface from all sources of mechanical irritation, and purifying it from all septic contamination. The inflamed part must be kept at rest, and if necessary raised from a dependent position (i.e., the leg must not be allowed to hang down), whilst the sore is dressed with moist and warm antiseptic applications, such as a boracic poultice. When the parts are very offensive, a charcoal and linseed-meal poultice may be first employed. The state of the bowels and constitution must be attended to, and probably a mild purgative will be needed. Stage II. : The Transition Period comprises all the changes which occur from the termination of the ulcerative process proper to the time w r hen healing is fully established by the wound becoming covered with granulations. In short, it may be described as the stage of preparation for healing. Naked-eye Appearances. — When the destructive process has ceased, and the septic element has been eliminated, the surface of the ulcer begins to clean, and becomes, as it were, glazed over ; sloughs and portions of dead tissue are either removed in the dressing or absorbed by the activity of the leucocytes and fibroblasts. The discharge becomes less abundant and more serous in character, and the angry red blush is replaced by a rosy hyperaemia. The infiltration of the base also diminishes, so that the tissues around are less fixed and more supple. The film on the surface becomes more and more defined, and in the course of time, shorter or longer, according to circumstances, little red spots make their appearance here and there ; these gradually increase in number and size, and coalesce, until the whole surface is covered by what has now become granulation tissue. The processes occurring in this stage are : (a) the removal of the sloughs ; (b) the covering of the surface with a cellulo-plastic exudation ; and (c) the vascularization of this newly-formed material, and its conversion into granulation tissue. Microscopic Appearances. — When the action of the irritant has ceased, the migration of the leucocytes lessens, and the destruction of tissue comes to an end. The surface of the ulcer is now covered with a layer of round cells, mainly derived from the pro- liferation of the neighbouring connective-tissue elements, and intermixed with fibrin in such a way that the cells lie in the interstices of the fibrillae ; this constitutes the film mentioned above. The vessels in the area, where merely stasis has occurred, become patent, and the circulation in the neighbourhood of the ulcer is thus restored. The vascularization of this superficial film is next undertaken, according to the process described in Chapter VIII. The wound thus becomes covered with granula- tion tissue, and with its formation the processes included in the second stage come to an end. All the forms of chronic ulcer which are neither spreading nor actively ULCERATION 61 healing may be included in this transitional stage, viz., the indolent or callous ulcer, the irritable, the varicose, etc. The Indolent or Callous Ulcer occurs most frequently on the legs of women about the middle period of life. The size varies greatly, but they are sometimes so extensive as to involve the whole circumference of the limb. It may also follow large burns on any part of the body ; healing proceeds to a certain extent, and then stops from the fact that the contraction of the cicatricial tissue already formed interferes with the vitality of the part still unhealed by compressing the vessels, and so cutting off the granulations from their source of nutriment. The surface is usually smooth and glistening, and of a dirty yellow colour, with perhaps a few badly-formed granulations ; the edges are hard and sharply cut, and elevated considerably above the surface, whilst the skin around may be heaped up over the edge, and either covered with sodden cuticle or congested. The skin of the limb is often deeply pigmented from chronic congestion, the pig- mentation starting in the separate papillae as maculae, which gradually coalesce. The discharge is purulent or serous, and may be so abundant and irritating as to cause eczema of the parts around, and thus give rise to one form of eczematous ulcer. The base is adherent to the underlying tissues, fasciae, etc. ; and this constitutes one of the main difficulties in healing, as contraction of the sore is thus prevented. If the ulcer extends to the periosteum, as happens not unfrequently when placed over the shin, chronic periostitis, or even osteitis, results, and a sub- periosteal node is formed, corresponding exactly to the size and situation of the ulcer, forming a mushroom-shaped projection, and possibly going on to necrosis, or to enlargement of the whole bone. In some very chronic cases the superficial lymphatics and veins are so much compressed as to cause chronic oedema of the foot, often of a very solid, brawny type, and the limb may even pass into a condition of pseud-elephantiasis. The so-called Irritable Ulcer is usually met with in this stage. Its chief peculiarities are the position, generally in the neigh- bourhood of the ankle, and the pain which accompanies it. The surface of a healing or chronic ulcer can usually be touched with- out the patient complaining ; but in this variety the pain is ex- cessive, especially at night. It was pointed out by the late Mr. Hilton that, if a probe is run lightly over the surface of such a sore, one or more spots will be indicated as the chief seats of the pain, the rest being insensitive. In all probability, nerve fila- ments are there exposed, as the pain has a very marked burning or shooting character. The Varicose Ulcer occurs in the leg of a patient who is the subject of aggravated varicose veins. The skin becomes passively congested, and its nutrition is consequently impaired ; any injury or abrasion, which would readily heal in a sound limb, is likely 62 A MANUAL OF SURGERY under such circumstances to give rise to a chronic sore. Again, it may be preceded by eczema resulting from the irritation of dirt or the friction of hard trousers, whilst occasionally it may be due to the yielding of the thinned skin which forms the only covering of a much dilated vein, an accident often leading to severe haemor- rhage. The characters of a varicose ulcer vary considerably, but in the main they correspond to those of the second or transitional period, and are usually found on the inner and lower portions of the leg, whilst syphilitic sores are more often placed nearer the knee and on the outer side. The Treatment of ulcers in this stage differs according to the conditions present. If it is merely a passing phase in the progress of an ulcer tending rapidly to repair, all that is needed is to con- tinue the same course of treatment as was adopted at an earlier period of the case, viz., rest and protection from irritation. It may be advisable to shield the surface from contact with dressings by the intervention of a small portion of purified ' protective '• — i.e., oiled silk coated with dextrin — so that the reparative material may not be damaged during their removal. The Chronic Ulcer needs much care in its treatment, and some cases require operative interference. Rest in a more or less elevated position is absolutely essential in order to relieve the congested condition of the limb ; whilst if the surface is foul, a charcoal poultice may be beneficial, or the sore may be dusted over with iodoform, and boracic poultices applied. This may be preceded in some cases by touching the surface with nitrate of silver, or with a solution of chloride of zinc (40 grains to 1 ounce). Pressure has been found of considerable service in the treatment of these ulcers ; an ordinary bandage, reaching from the toes to the knee, will suffice in some cases, a suitable dressing of boric acid ointment, with perhaps some resin ointment added to make it more stimulating, being applied beneath it. Martin's india- rubber bandage is more useful when the veins are much enlarged. The method of dealing with chronic ulcers suggested by Pro- fessor Unna, of Hamburg, has given excellent results. It con- sists in the use of an adhesive plaster, made up as follows : Gelatine, 5 parts ; oxide of zinc, 5 parts ; boric acid, 1 part ; glycerine, 8 parts ; water, 6 parts ; to this ichthyol (5 per cent.) may be added with advantage. The limb is first thoroughly washed with soap and water, and purified with carbolic lotion (1 in 20). It is then wrapped round with a single layer of anti- septic gauze, and the paste, liquefied by placing it in a gallipot in a saucepan of boiling-water, is applied over it with a paint or paste brush. Another layer of gauze is placed over the paste and a thin bandage over all, and the whole allowed to dry. Where there is much varicosity of the veins, the paste should extend from the ankle to the knee, the foot being also included in some cases. If there is much discharge, the ulcer should not ULCER A TION 63 be covered, or the dressing should be reapplied in a day or two ; but after it has diminished in amount, the paste may be carried right over the sore, and the whole application left in position for a week, or even longer. When the edges are very indurated and thickened, and all action is at a standstill, Syme's suggestion may be followed, viz., the whole surface, as well as the surrounding skin, is blistered, and then a suitable dressing applied. A more satisfactory method, but requiring an anaesthetic, is to thoroughly scrape the surface with a sharp spoon, and then to rub in a strong solution of chloride of zinc. As soon as healthy action is established, skin- grafting may be undertaken, if necessary, but it is useless to undertake this unless the patient can promise to rest up for a prolonged period, and even then elastic support will be sub- sequently required. In very bad cases where a considerable portion of the circumference of the limb is involved, when the ulcer is very callous and its base attached to the tibia, causing severe pain at night from chronic periostitis, and especially when the patient is unable to indulge in much rest, amputation may be the best treatment. It will often be found that Faraboeuf s amputa- tion at the site of election can be undertaken with advantage. Where varicose veins exist, treatment is of little avail unless these are efficiently dealt with either by operation or by some suitable support. Unna's paste often answers this purpose most admirably. The Irritable Ulcer may be treated by discovering the painful spots, and incising the tissues just above them with a knife, so as to divide the exposed nerves ; but thorough scraping under an anaesthetic is preferable. The Eczematous Ulcer must be dealt with differently from the others, or the eczema will be aggravated. Soothing applications are needed, such as lead lotion, and when once the acute stage has passed, tarry preparations (liq. carbonis detergens, 1 ounce to 1 pint of lotio plumbi), or an ichthyol ointment (5-10 per cent.), may be beneficially employed. A mixture of benzoate of zinc and boric acid ointments is a very useful application, or Unna's paste with ichthyol may be utilized. Stage III. : Repair having now been fully established, we have merely to deal with, not a healthy ulcer, for such a condition cannot exist, but a healthy granulating wound, the result of ulceration, or, as we call it, to avoid confusion, a ' healing ulcer.' A Healing Ulcer is characterized by the following conditions : Surface, smooth and even, shelving gradually from the skin, and covered with healthy granulations ; these present a florid red appearance, are painless, and bleed, but not readily, on being touched. The discharge varies according to the plan of treatment adopted : if the surface is kept at rest and free from all irritants, either septic or antiseptic, the discharge is merely serous ; but 64 A MANUAL OF SURGERY 0/ should the wound become septic, or be dressed with irritating antiseptics, ordinary pus is formed. The surrounding skin is soft, flexible, and free from inflammatory congestion ; the base is similarly free from fixity : whilst the margins present a healing edge, which has been described as manifesting three coloured zones : within is a red area consisting of granulation tissue, covered by a single layer of epithelial cells which cannot be seen except in a good light ; next comes a thin dusky purple or blue line, where the granulations are covered by a few layers of epithelium, and the circulation is becoming retarded owing to cicatricial development ; whilst outside is a white zone due to the heaping up of sodden cuticle upon the healthy or healed part. The method of repair in such a wound consists in a change of the deeper layer of granulations into fibro-cicatricial tissue, which gradually contracts and is finally covered with epithelium. For full description see Chapter VIII. Occasionally if emollient applications are used too freely and too long, the granulations become pale, protuberant and cedema- tous, and the healing process is temporarily checked. A depressed general condition of the patient, or a varicose condition of the veins, may also account for this, and the term a weak ulcer is applied to it, whilst the prominent flabby granulations are popu- larly known as proud flesh. The Treatment of a healing ulcer is simple in the extreme. All that is needed is to guard the surface from irritation, and Nature will rapidly bring about a cure. The part must be kept at rest, and if the leg is the seat of the trouble, it should not be allowed to hang down. The wound is dressed with any simple unirritating antiseptic, and perhaps boric acid lint is as good as any ; a piece of protective, the exact size of the sore, may with advantage be interposed between the lint and the wound, or boric acid ointment may be spread on the lint. If the granulations become too promi- nent, they may be lightly touched with nitrate of silver, and a more stimulating lotion applied, such as that known as lotio rubra (R. Zinci sulphatis, gr. ii. ; tinct. lavandulae co., spir. rosmarini, aa TT1_ xx. ; acidi borici, gr. x. ; aquam. destill. ad 5 i.). Large ulcers require some assistance in order to obtain expe- ditious healing, otherwise a time comes when the contraction of the cicatricial tissue interferes with the nutrition of the granulations, and retards the healing process. Various plastic operations have been adopted to obviate this difficulty, and also the different methods of skin-grafting. Skin-grafting, or the transplantation of more or less of the thickness of the skin from a healthy to a healing part, was intro- duced by Reverdin in 1869, and has since been much elaborated. The following are the chief methods employed : 1. Transplantation of small pieces of the cuticle and cutis, Reverdin's original plan. A small portion of the cutaneous ULCERATION 65 tissue is pinched up with or without forceps, and removed by a pair of sharp curved scissors. In thickness it should include the cuticle and a portion of the cutis vera, so that a drop or two of blood will slowly ooze from the denuded surface. The graft is placed cutis downwards on the surface of the granulations and covered with protective, purified in boric acid. Many of these may be applied at the same time, and the whole w r ound carefully dressed and protected. If there is much discharge, the grafts will not 'take'; but if the wound is merely discharging serum, there should be no difficulty in getting them to grow. Usually they disappear for a day or two, from the cuticle becoming softened or disintegrated ; but soon the epithelium of the cutis spreads, and makes itself visible as a distinct centre of repair. The greatest gentleness is needed in handling the graft, as it readily perishes. 2. Transplantation of large portions of cuticle as suggested by Thiersch. This method consists in removing wide strips of cuticle with a razor, and implanting them on a fresh wound or on a raw surface previously denuded of all granulations. The ulcerated surface is first scraped, and the resulting haemorrhage stayed by pressure with a sponge, a layer of protective being, however, interposed, so that when the sponge is subsequently removed the bleeding shall not recur. The strips of cuticle are then cut, care being taken to make them as thin as possible ; the papillae are always encroached on, however, and hence some amount of blood escapes, in which the grafts are allowed to remain soaking until required for use. When it is thought that sufficient material has been obtained, the sponge and protective are removed, and the grafts gently transferred, being applied in such a way that they overlap each other and also the margins of the defect. There is always some tendency for the edges of the graft to turn in, and this must be prevented. They are then covered with protective, or thin silver-foil, and the whole dressed antiseptically. There is usually no need to look at the wound for some days. The outer sides of the thigh or arm are the best places from which to take the grafts. By this method subsequent contraction is to a large extent prevented. 3. The whole thickness of the skin is used in some instances. Thus, the preputial tissue removed in circumcision is most valuable for this purpose, being soft and flexible. All redundant and fatty tissue must be removed, and only the skin applied. The granulations should always be previously scraped away, and the graft stitched down to the underlying cicatricial tissue with fine catgut. It may also be applied to the raw surface of an operation wound. II. Ulcers due to Specific Bacteria. The different forms of infective ulcers met with in surgical practice will be described under the appropriate headings in 5 66 A MANUAL OF SURGERY different parts of the book. It will suffice here to mention them : Soft Chancre (Chapter XXXVIII.).— This may be taken as a type of all infective ulcers, clearly showing the stages of infection, incubation, ulceration, and repair. Ulcers due to Syphilis (Chapter VI.) : (a) The primary sore. (b) Secondary ulcers, mainly of mucous membranes, but sometimes involving the skin, and due to the breaking down of so-called tubercular syphilides. (c) Intermediate, rupial, or ecthymatous sores. (d) Tertiary ulcers from the disintegration of gummata, either superficial and multiple, or deep and single. In inherited syphilis, any or all of the above varieties may be seen, except the primary sore. Phagedenic ulceration (p. 125) is usually associated with syphilis, but whether the phagedena is itself due to a specific organism is a little doubtful. Ulcers due to Tubercle : (a) The lupoid ulcer, due to a cutaneous tuberculosis (Chapter XIV.), or (b) The tuberculous ulcer, arising as a rule from the bursting of a subcutaneous or submucous tuberculous abscess (Chapter XIV.). (c) Various other tuberculous ulcerative lesions of the skin are described by dermatologists under the title 'scrofulodermia,' whilst Bazin's disease (or erythema induratum) is possibly tuberculous in origin. Malignant Pustule, due to the Bacillus anthracis (p. 1 13). III. Malignant Ulcers. These are due, as has already been pointed out, not to any inflammatory process, but to the actual replacement of the skin by the growth, so that loss of substance necessarily ensues. It is only requisite to mention the varieties here ; a fuller description will be appended later (Chapter VII.) : (a) Rodent ulcer, a chronic cancer starting in the sebaceous glands or hair follicles, and accompanied with very little over- growth. (b) Epitheliomatous ulcer, arising from cancer of the skin or mucous membranes. (c) Scirrhous ulcer, resulting from destruction of the skin over a scirrhous tumour. (d) Fungating ulcer, where a neoplastic growth protrudes from the skin. It may be caused by a soft encephaloid cancer, or a sarcoma, whilst a cysto-adenoma mammae gives rise to a similar appearance. It constitutes the condition formerly known as a ' fungus haematodes.' CHAPTER V. GANGRENE. By gangrene is meant the simultaneous loss of vitality of a con- siderable area of tissue. If the process is limited to the soft parts of the body, it is often termed sloughing or sphacelation, and the dead mass a slough or sphacelus ; if a tangible portion of bone dies, necrosis is said to have occurred, and the necrosed mass is called a sequestrum ; while the term gangrene is more especially applied to a necrotic process affecting simultaneously the hard and soft tissues of a limb. General History of a Case of Gangrene. Signs of Death. — Death of a limited portion of the body can be recognised prior to the supervention of evident post-mortem changes within it by five characteristic signs : i . Loss of pulsation in the vessels. 2. Loss of heat, since no warm blood is brought to it. 3. Loss of sensation, although much pain may be experienced whilst death is occurring, and such may be referred to the dead part through irritation of the nerves above. 4. Loss of function of the gangrenous mass, which, if it is a limb, lies flaccid and motionless. 5. Change of colour, the character of which depends on the amount of blood in the part at the time of death ; if the limb is full of blood, it becomes purple and mottled ; if anaemic, a waxy or cream colour results. These five signs may be in measure present when the vitality of a limb is seriously depressed, as by ligature of the main vessel or by its embolic obstruction ; but if they continue for any length of time, death is practically certain to ensue, and they will then be rendered more obvious by the phenomena about to be described. Changes occurring in the Dead Tissues.— The character of these changes depends mainly on the condition of affairs at the time of death, and whether or not putrefaction supervenes. The following conditions are described : 68 A MANUAL OF SURGERY i. Dry Gangrene ( = death + mummification). — Such can only occur when the tissue involved is, previous to its death, more or less drained of its fluids, so that it readily shrivels up and loses its moisture. The usual cause is chronic arterial obstruction, as brought about by atheroma or calcification of the terminal arteries, to which a sudden or gradual complete occlusion of the main trunk is often superadded. The dead part becomes hard, dry and wrinkled, and is of a dark-brown or black colour from the diffu- sion of the disintegrated haemoglobin (Fig. 7). The more fleshy parts (for instance, the tissues above the ankle) rarely undergo complete mummification, and the surrounding living tissues are often considerably inflamed. If sepsis be admitted, the parts may become horribly offensive. 2. Moist Gangrene arises when a part of the body full of fluid Fig. 7. — Senile Dry Gangrene, affecting both Feet. dies, and is especially associated with any obstruction on the side of the veins, or with acute arterial thrombosis in a previously sound limb, e.g., in traumatic gangrene due to pressure upon, or rupture of, the main trunk. The loss of the vis-a-tergo derived from the heart's impulse causes a negative pressure in the capil- laries, which become filled by regurgitation from the veins. Obviously, such a condition is well suited for the development of the organisms, which always exist in numbers on the skin, and unless the most vigorous efforts are made to render it aseptic before or immediately after death, moist gangrene is certain to be associated with putrefaction. Unhappily, this precaution is but seldom adopted, or even available, and hence in the majority of cases putrefaction occurs ; it must be clearly understood, however, that it is no essential part of the gangrenous process. Aseptic Moist Gangrene is characterized by the dead tissues becoming more or less discoloured, either purple or any shade from black to yellow, green or white. It remains of much the same size and consistency as at the time of death so long as it is GANGRENE 69 kept from contamination, and is then simply and quietly cast off from the surrounding tissues without any obvious inflammatory disturbance, although a certain amount of toxaemia may result from the absorption of various products from the dead tissues. Septic or Putrid Moist Gangrene (Fig. 8) is necessarily asso- ciated with a rapid breaking-up and disintegration of the mass, which becomes black, green, or yellow. The cuticle is raised from the cutis vera by blebs containing stinking serum, or even bubbles of gas, and these can be readily pressed along under the epidermis for some distance. The tissues of the limb are soft and lacerable, and on grasping it emphysematous crackling is usually noted. The Later History of a gangrenous mass depends entirely on its asepticity or not, and on its bulk. (a) If the necrotic area is small in size and aseptic, it may, under favourable circumstances, be entirely absorbed in the same f C Fig. 8. — Septic Moist Gangrene of Leg. way as is a catgut ligature. Such is often observed after slough- ing of small portions of amputation flaps ; if the part is kept dry and aseptic, it is gradually removed, and when the process is completed, a small dark scab will fall or be picked off, and a cicatrix found beneath it. In a similar way dead bone may be absorbed, if the sequestrum is not too large or too dense, and if it is in close proximity to healthy vascular tissue. Thus, a child came to the hospital with a portion of the outer table of the skull, as large as the palm of a man's hand, quite bare and dead, as the result of sloughing cellulitis ; it was treated antiseptically, and granulations gradually sprang up through the bone in all direc- tions, until finally the whole was absorbed, with the exception of merely a small flake, the size of one's little finger nail, which separated. The dead portion is first invaded by leucocytes from the lymphatic spaces or vessels of the immediately contiguous living tissues, and infiltrated by them and the accompanying blood plasma. By a process of auto-digestion this infiltrated portion disappears, and is replaced by granulation tissue (for the origin of which, see Chapter VIII.), which in turn is converted into a cicatrix, and covered with cuticle in the usual way. 7 o A MANUAL OF SURGERY (b) If the mass, though aseptic, is of such a size, or consists of such tissues, as to prevent its total absorption, or if the vital activity of the patient is lowered, a modification of the same pro- cess results in partial absorption of the dead material, whilst the re- mainder is cast off and separated by a simple process of anaemic ulceration. The dead part immediately contiguous to the living is removed and replaced by granulation tissue, and this change continues advancing into the mass until the layer of granulations which has penetrated furthest is at such a distance from its nutritive basis as to be unable to derive from it sufficient pabulum, owing to the contrac- tion of the cicatricial tissue which is forming behind ; and then a simple ulcerative process from defective nutrition causes a line of cleavage to form between the living and dead, by means of which the latter is separated from the body. The size of the portion thus cast off is distinctly less than that of the original necrotic mass. Whilst this is occurring, there is no local inflammatory reaction, and but little resulting constitutional disturbance. It is slow in progress, but there are none of the risks attaching to the more rapid septic proceeding. Of course, the denser and harder the tissues, the longer they take in separating, and hence it is possible for the soft tissues of a limb to have separated, and the wound caused thereby to have cicatrized before much impression has been made on the bones. Considerable retraction ensues, giving rise to a conical stump from the apex of which the bones protrude. (c) If the gangrenous portion is septic, its separation is accom- plished by a distinctly inflammatory act taking place in, and at the expense of, the surrounding living tissues. The extent of the gangrene is primarily indicated by a line of demarcation, due to the change in colour occurring in the dead part, the living tissues retaining their normal hue. The irritation of the chemical products formed in the necrosed mass causes in a few days inflammation in the surrounding structures, resulting in hyperemia and subsequent exudation of plasma and leucocytes ; the tissue of the part dis- appears, and is replaced by a cell infiltration, which in turn breaks down into pus, whilst a layer of granulation tissue forms at the limit of the living portion, and thus the final line of separation is produced. Clinically, one notices in this latter stage a bright red line of hyperaemia at the extremity of the living tissues, which gradually spreads and deepens until about the eighth or tenth day, when, if the cuticle is intact, the living and dead parts are separated by a narrow white or yellow line, which is proved, on pricking the epidermis, to be due to the presence of a layer of pus ; as the pus escapes, a shallow groove is seen, running between a granulating surface on the side of the living tissues and the gangrenous mass. This process, gradually extending through the whole thickness of the limb, is attended by the local signs of inflammation and by fever, the degree of the latter depending on the GANGRENE 71 amount of putrid material absorbed. The inflammatory process, moreover, is not always limited to the line of separation, but may spread upwards along the lymphatics or veins, or in the fascial and muscular planes, until, perhaps, the whole limb is involved in an extensive suppurative process. The Constitutional Symptoms of gangrene may be described under two distinct headings : (a) Those general conditions which predispose to the occurrence of gangrene, and which are mainly of a debilitating character, affecting either the composition of the blood or the vitality of the limbs. Thus, the patient may be suffering from general asthenia, such as results from preceding fevers ; or his circulation may lack vigour either from weakness of the heart muscles or from some valvular lesion ; or, again, his arteries may be so diseased, or rendered so rigid by atheromatous or calcareous changes, that, although a sufficient supply of blood may reach the extremities for all ordinary circumstances of life, yet any unusual demand upon the circulation cannot be met. Many evidences of mal- nutrition usually manifest themselves before the onset of gangrene. General diseases, such as diabetes and albuminuria, may be present, as also the constitutional results of a vicious life. (b) Those conditions depending on the presence and connection with the body of the dead tissue. Various forms of septic or ptomaine poisoning result, usually causing fever, asthenic in type and variable in amount. Pain, moreover, is frequently a prominent feature in some forms of gangrene, and the patient is sometimes liable to become exhausted from this cause, even though he is protected by the surgeon's care from the dangers of sepsis. The Treatment of gangrene naturally divides itself into the local and general. We shall not discuss the question of Local treatment at this place, leaving it to be dealt with under the appropriate headings hereafter. As to General treatment, but little need be said beyond that the strength of the patient must be maintained by plenty of easily assimilable food, sufficient stimulant, and tonics. Pain and sleeplessness must be combated by the administration of a suitable amount of opium or morphia, if the kidneys are healthy. Diabetes and albuminuria need dietetic and therapeutic measures in order to limit, if possible, the excre- tion of sugar and albumen. Varieties of Gangrene. Having thus traced in outline the general history of a case of gangrene — the signs of death in the part, the various post-mortem changes which may occur in it, the means whereby Nature rids the body of such an encumbrance, and the various dangers, local and general, the patient runs — we now turn to the different forms 72 A MANUAL OF SURGERY of the disease which are met with, and propose to discuss them seriatim. The following classification is one which, though admittedly imperfect, does in a measure group together allied types of the affection, and will serve as a useful one for practical purposes. I. Symptomatic Gangrene, or that predisposed to by preceding vascular or general conditions, where a trauma, if present at all, is of very slight significance. (a) Gangrene from embolus. (b) Senile gangrene. (c) Gangrene from arterial thrombosis (non-senile). (d) Diabetic gangrene. (e) Raynaud's disease. (/) Gangrene due to ergot. II. Traumatic Gangrene, which may be due to direct or indirect injury, and where the damage done to the vessels or tissues by the trauma is the immediate cause of the loss of vitality. Two varieties of this may be met with, viz. : (a) The indirect, where the lesion involves the vessels of the limb perhaps some distance above the spot where the gangrene occurs. (b) The direct, where the gangrenous process is limited to the part injured. III. Infective Gangrene, which arises from the activity and influence of micro-organisms. (a) Acute inflammatory or spreading traumatic gangrene. (b) Wound phagedena and hospital gangrene. (c) Necrosis of bone (most cases). (d) Noma and cancrum oris. (e) Carbuncle and boil. IV. Gangrene from Thermal Causes — frost-bite and burns. Each of these varieties must now claim separate and individual attention. I. Symptomatic Gangrene. (a) Embolic Gangrene. (For general details as to emboli, see Chapter XI.) When the main artery of a limb becomes blocked by a simple embolus, the condition is exactly similar to that which obtains after ligature — i.e., the vitality of the part is diminished until such a time as the collateral circulation is established. Under ordinary circumstances it should not lead to gangrene ; but if either the general or local vitality is much reduced, the obstruction of the main trunk may be sufficient to determine the death of more or less of the limb. There are two chief conditions under which gangrene is likely to follow an embolus : (i.) Where the embolus consists of a fibrinous vegetation detached from one of the cardiac valves in a case of endocarditis following rheumatic or other fevers. The general nutrition has been depressed by the preceding fever, the heart's GANGRENE 73 action- 'is weak, and the circulation possibly impeded by the valvular lesion, so that the block of a main trunk, even in a young person, is often sufficient to determine gangrene, (ii.) It also follows when a detached atheromatous plate blocks the main vessel of a limb previously rendered anaemic by arterial degenera- tion, an occurrence not unusual in elderly people. Emboli are most commonly arrested at the sites of division of the main trunks (Fig. 9, A), or where the calibre is suddenly diminished by the origin of a large branch, the embolus often saddling over the bifurcation, and thus, as it increases in size by the subsequent deposit thereon of fibrin, effectually closing both branches (Fig. 9, B). In the lower limb it occurs at the division of the femoral or popliteal ; in the upper, at the origin of the superior profunda, or where the brachial divides. Fig. 9. — Diagrams of Embolus saddling the Bifurcation of an Artery. In A the embolus is seen, and the commencement of a thrombus on it, but not yet obstructing the vessel ; in B both branches of the trunk are blocked by the growth of the clot. The chief early Symptom is pain experienced both at the point of impaction and also down the limb along the course of the vessel. Pulsation below the block ceases, sensation and tempera- ture diminish, and the part feels heavy and useless. If the vessels are healthy, stagnation of blood in the veins is an early result, the terminal portion of the limb becoming congested and cedematous, and finally passing into a condition of moist gangrene. If, however, the terminal arteries are calcified or atheromatous, so that the limb is in a state of chronic anaemia, dry gangrene is likely to follow. The process starts peripherally, and spreads gradually upwards until it reaches a level where there is sufficient circulation to maintain the life of the part. Such usually obtains in the neighbourhood of a joint, since there is always a more free anastomosis here than in the inter-articular portions of the limb ; 74 A MANUAL OF SURGERY thus, in the leg the gangrene is arrested either immediately above the ankle or below the knee. The subsequent history depends upon whether or not the dead tissue is allowed to become septic, and requires no special notice. Treatment. — The all-important requisite in dealing with a case of this nature is to prevent the advent of sepsis, since it may transform what would otherwise be a. condition associated with but little danger into one of the gravest moment. As soon as possible after the obstruction has taken place, and before any absolute signs of death are manifest, scrupulous care must be taken to purify the part. The nails should be cut, and the whole limb thoroughly but gently scrubbed With carbolic lotion (i in 20), special attention being directed to the intervals between the toes and the semilunar folds of the nails. It should then be wrapped in a layer or two of moist and purified gauze, swathed round with salicylic, iodoform, or sterilized wool, and lightly, though firmly, bandaged. The limb is kept slightly raised, so as to prevent venous regurgitation without interfering with the arterial supply, and by this means gangrene may be prevented. If, however, these precautions are not successful, and the part dies, the same measures as to the maintenance of asepsis must be continued until a natural line of separation forms. In old people with dry gangrene similar rules are followed as for the senile type ; but in the moist form, occurring in young people, the natural process of separation may be hastened by severing the dead from the living and sawing through the bone, or possibly amputation through the living tissues a little above may be considered advisable, a more shapely stump being thus obtained. Where sepsis has occurred, it is wise to amputate through healthy tissue as soon as the gangrenous process has finally ceased to extend. If, however, spreading septic inflam- mation exists, one may be driven much higher up the limb than would be otherwise necessary, whilst very acute septic symptoms may determine amputation before any line of separa- tion has formed. (b) Senile Gangrene is a condition which, as the name implies, occurs in elderly people, and is the result of imperfect nutrition of the tissues. The toes are most frequently affected, but it is also seen in the hand, and may attack the nose, ears, or even the tongue. Causes. — These are to be found mainly in the condition of the circulatory organs. (a) Calcareous degeneration (Chapter X.) of the smaller vessels of the limb or part is always present, as also possibly atheroma of the larger arteries. The vessels in con- sequence become pipe -like and inelastic, and incapable of accom- modating themselves to the requisite variations in the blood- supply. Hence a fixed minimal amount of blood enters the limb, which passes into a chronic state of anaemia and malnutrition, GANGRENE 75 whilst the tunica intima is often so rough as to predispose to thrombosis with or without injury, (b) A iveak heart is generally present, leading to low pulse tension, and increased difficulty in propelling the blood through the rigid and narrowed vessels ; and (c) the condition of the blood may be impoverished by albuminuria. When such predisposing factors are present, anything that results in (d) thrombosis either in the main trunks or in the peripheral arterioles or capillaries is likely to determine the onset of gangrene. Throm- bosis of the main vessels may be due to some injury to the limb which often passes unnoticed, or more frequently arises from a gradual deposit of fibrin on the already roughened walls. If the obstruction originates in the smaller trunks or capillaries, it is generally brought about by some slight injury, such as striking the ball of the great toe against the table, or even cutting a corn. Exposure to cold may also act as an exciting agent. In either case the clotting extends for some distance, and the height to which the gangrene spreads will vary accordingly. Symptoms. — Preliminary evidences of malnutrition of the limb will probably have been noticed for some time in the form of cramp and pain in the muscles, which become fatigued rapidly, whilst sensations of pins and needles or numbness are also complained of. The circulation in the tibials may be so slight as to be scarcely perceptible, and the whole limb feels cold and heavy. The skin is frequently more or less congested, and extremely prone to low forms of ulceration or eczema. When the gangrene commences as a result of some peripheral lesion, an area of painful redness is first noticed, perhaps running on to ulceration, and in the centre of this patch a slough is formed, which becomes dry and black. The process gradually spreads from this focus with more or less inflammation, so that it is sometimes known as inflammatory senile gangrene. If, however, it results from throm- bosis of the main vessels, death occurs without the supervention of local inflammatory phenomena, the toes merely shrivelling up and dying {non-inflammatory senile gangrene). The inner side of the great toe is perhaps the commonest situation for the com- mencement of the mischief, and thence it spreads from one toe to another, and also along the instep and up the ankle to the leg. Pain is always a marked feature, whilst the extent of the gan- grene is dependent partly on the amount of general and local vitality, and partly on the asepticity or not of the surrounding tissues. As the disease spreads, the patient becomes exhausted by the long-continued pain and want of sleep ; and septic fever, bedsores, or the intervention of some cardiac, pulmonary, or renal complication, may also hasten a fatal termination. The Treatment adopted until within the last few years was governed by the observation that any attempt to remove the dead tissues by amputating through neighbouring living parts is doomed to failure, since the gangrenous process is certain to 76 A MANUAL OF SURGERY commence again in the flaps ; if merely cutting a corn suffices to originate the malady, much more does so severe an injury as an amputation. The parts were dusted with iodoform or some similar antiseptic, and wrapped in cotton-wool to keep them warm ; the surgeon then waited for a line of separation, and even then did not amputate, but merely assisted Nature by dividing tendons or bones. At the same time, the general health was maintained by the judicious administration of suitable nourishment, stimulants and tonics, whilst pain was alleviated by the use of opium in such doses as the condition of the kidneys allowed. In spite of every care, however, the enfeebled constitu- tion of the patients often proved unequal to the task of ridding the body of the dead mass, so that death from exhaustion or blood-poisoning was the rule rather than the exception, and even if the patient did recover, the prolonged and enforced stay in bed considerably diminished his vital powers. It has now, however, been clearly demonstrated that early amputation performed under careful antisepsis, and well away from the dead mass at a point where the surgeon considers the blood- supply sufficient to nourish the flaps, and yet not so near the trunk as to seriously threaten life through shock, holds out the best prospects of relief. In order to determine the most favour- able site for the amputation, the pulsation in the main artery should be felt for, and if feasible no operation performed at a spot where it appears to be occluded. The condition of the limb will also influence the surgeon's decision ; if thin, attenuated, and shrivelled, it will be wise to amputate high ; but if the limb is fairly well nourished and with plenty of adipose tissue, the operation may be performed somewhat lower. In operating, as little damage as possible should be inflicted on the parts, the flaps being nearly equal in length and not too flimsy, a circular amputation, or some slight modification of it, being perhaps the best. In cases where the mischief is limited to the foot, it is usually advisable to amputate through the lower third of the thigh, or at any rate in the neighbourhood of the knee-joint, though not through the joint itself, as the flaps in that operation are always rather flimsy. We have followed this line of practice for some years, and have no reason to be dissatisfied with our results. Dissection of the portions removed has always shown that the vascular trouble was fully as advanced as we had anticipated, and that no minor measures would have sufficed. (c) Gangrene from Arterial Thrombosis (non-senile) is not a common occurrence. It arises as a result of that curious affection endarteritis obliterans, and also develops in some young people in scattered patches about the skin without any of the characteristic phenomena of Raynaud's disease. It sometimes occurs in connec- tion with typhoid fever and other conditions of severe toxaemia as an outcome partly of the increased coagulability of the blood, partly GANGRENE 77 of a localized endarteritis, due to the toxins present in it. The femoral artery is most usually blocked, but occasionally the trouble will spread up to the aorta and involve both legs in the gangrenous process. Unless the vein is also involved, the gan- grene is usually of the dry type. It is wise to wait until a line of demarcation has formed, and then amputate well above. (d) Diabetic Gangrene is mainly due to the abnormal condition of the blood in diabetes, thereby reducing the power of the tissues to resist bacterial invasion ; but it is also in measure the result of a sclerosing endarteritis and peripheral neuritis. It is not commonly met with in the subjects of acute diabetes, nor, as a rule, in people below forty years of age. It results usually from some slight traumatic or infective injury, and often commences on the under side or at the extremity of one of the toes as a bleb, surrounded by a dusky purple areola. When the bleb is opened or bursts, the central portion of the underlying tissue is found to be necrotic, and from this focus the gangrene spreads, taking on a moist or a dry type according to the amount of vascular disease. Not uncommonly extensive suppurative infiltration of the soft parts of a limb may be associated with a limited gangrene of a peripheral segment. In the Treatment an attempt should be made to reduce the excretion of sugar by administering codeia and regulating the diet, but too much time must not be lost. A careful investiga- tion of the condition of the vessels is necessary. If they are tolerably healthy, removal of the dead tissue by an amputation not very much above the upper limit of the disease is justifiable ; but should there be evidence that the main trunks are affected, then either the separation of the necrosed mass must be left to Nature, the surgeon merely assisting by the division of bones, or preferably, if the patient's general state is good, a high amputation may be undertaken. Under the latter circumstances, however, there is some risk of the supervention of diabetic coma. The same practice would be required if extensive inflammatory mis- chief were present. (e) Raynaud's Disease, or Spontaneous Symmetrical Gangrene, is a condition usually met with in anaemic or neurotic young women between the ages of fifteen and thirty. It is due to vaso-motor spasm, dependent either on some deep unrecognised lesion of the spinal cord, or in some cases to a peripheral neuritis. It occurs in conditions of nervous exhaustion, and has been started by a sudden fright. Three stages are usually described : (i.) local syncope or anaemia, arising as the direct result of arterial spasm, and characterized by pallor and painfulness of the part ; (ii.) local asphyxia or congestion, in which the affected tissues are blue and cyanosed from venous regurgitation ; and (iii.) necrosis, the part becoming dry and black, though it is unusual for the gangrene to extend at all deeply. The onset is often sudden, and the disease 7 8 A MANUAL OF SURGERY may last for a variable time, from days to months. If gangrene supervenes, the latter is the limit more often reached, but it by no means necessarily follows that tissue necrosis occurs in every case. The disease is usually symmetrical, and affects the fingers rather than the toes, but patches may occur on any part of the body ; the process is non-febrile, but often very painful. Paroxysmal haemoglobinuria has been observed, and is supposed to be due to vaso-motor disturbance of the kidneys. Ankylosis of the smaller joints, especially of the terminal phalanges, and localized patches of anaesthesia, associated with pain of a neuralgic type, are sometimes present, resulting from peripheral neuritis. The condition somewhat resembles the later stages of a chilblain, but is distinguished by its more dusky colour, the greater pain, the absence of itching, and the fact that the process is not limited to exposed or terminal parts, or to cold weather. The Treatment must in the early stages be directed to the pre- vention of gangrene. The constitution should be built up by iron, quinine, and if need be by stimulants, whilst menstrual irregularities must be attended to. Frictions with stimulating embrocations, warm douches, and protection from cold and injury, may be employed locally, but probably the best results will follow the use of electricity. The constant current is employed, and preferably in the shape of the electric bath, local or general as required, and repeated either once or several times a day. When actual gangrene is present, the dead tissue should be kept aseptic, when sooner or later it will be absorbed or separated. (/) Gangrene from Ergot is a rare phenomenon, but it has been known to occur when diseased rye has been used in the manu- facture of bread. The resulting gangrene may vary in extent from the loss of one or two fingers or toes to the sacrifice of the greater portion of one or more limbs. II. Traumatic Gangrene. By traumatic gangrene is meant the loss of vitality of some part of the body as the consequence of an injury, whether applied to the main bloodvessels (indirect traumatic gangrene), or directly to the tissues (direct traumatic gangrene). (a) Indirect Traumatic Gangrene arises from a considerable variety of lesions, and the course and clinical history are similarly variable. (i.) Ligature of the main artery does not produce gangrene in a healthy limb ; but should it be in a state of chronic malnutrition and anaemia from preceding arterial disease, death of a certain portion may ensue, the case running a similar course to one of gangrene due to embolus. It is usually of the dry type, and limited to one or two toes ; but if it reaches the more fleshy portions, the moist variety supervenes. GANGRENE 79 Where the gangrene is confined to the toes, Treatment consists in waiting for a definite line of separation to form under an anti- septic dressing, and then in assisting the natural processes at this spot by dividing tendons and bones. Where, however, a con- siderable area of the limb loses its vitality, and especially if the dead tissue is moist and septic, an early high amputation is required. (ii.) Arterial thrombosis from injury only causes gangrene under special circumstances, the course and treatment being similar to that resulting from an embolus. (iii.) Obstruction to both main artery and vein is an almost certain precursor of gangrene. A few cases are on record in which both vessels have been ligatured, or even portions of them removed without leading to gangrene, as in dealing with cancerous deposits in the axilla, or in the extirpation of aneurisms ; but in both these instances obstruction to the circulation must have previously existed, necessitating the opening up of collateral anastomotic branches. In a normal limb the occlusion of both afferent and efferent trunks is practically sure to determine tissue necrosis. It may therefore be caused by the inclusion of both vessels in a ligature, or by the strangulation of organs, either within the body, as in a strangulated hernia, or outside of it, as when a ligature is tied round the base of the penis, or a bandage applied too tightly round a fractured limb. It may even occur from the swelling up of a limb under a bandage which has been originally applied with no undue tension. A very similar result may be produced by the excessive hyperaemia and exudation following the sudden relief of a tight constriction around a part, which has thus been deprived of fresh arterial blood for some time ; the vessel walls are thereby so damaged that they are unable to resist the blood-pressure, and the amount of exudation that follows is so abundant as to rapidly bring the circulation to a standstill. Such an occurrence is met with after frost-bite, and also in a loop of bowel, which has been strangulated, after removing the obstruction to the circulation. Gangrene may also result from the rupture of a main artery and compression of the accompanying vein by the extravasated blood, an occurrence perhaps most frequently seen after fractures and dis- locations ; it is then always of the moist type. (See Chapter XVII.) Treatment varies considerably in these cases. If the parts are hopelessly injured amputation should be performed at once, so as to prevent the risk of sepsis. In some fractures and dislocations with vascular lesions, it may be possible to save the limb by cutting down, turning out clots, and securing the injured vessels, whilst the bony lesion is dealt with in a suitable manner. The limb should afterwards be elevated slightly, and the peripheral segment kept warm and aseptic. Should gangrene supervene, amputation will be required, its situation depending on the So A MANUAL OF SURGERY character of the local lesion ; if it is not of a serious nature — e.g., a clean fracture or simple dislocation — it is wise to wait for a line of demarcation ; but if comminution of bone or other grave local trouble is present, one would amputate above the injury. (b) Direct Traumatic Gangrene, or that resulting from the imme- diate effect of injury to the parts, is similarly due to a variety of lesions. (i.) Severe crushes or blows are a common cause of this type of gangrene ; thus a limb may become mangled between the wheels of machinery, or by heavy weights falling on it, or by the passage of vehicles over it. Not only are the parts crushed, severely con- tused, or even ' pulped,' but the bloodvessels may be torn, and the resulting extravasation contributes to the result. The gan- grene is of the moist type, and is more likely to supervene in patients whose vitality is diminished. Thus, a crush of the foot in an elderly person is often followed by it, when in a young and healthy adult it could be prevented. Treatment. — If the part is hopelessly damaged, there is not the slightest use in delaying operation, since the patient may run con- siderable risk from the onset of sepsis ; and therefore immediate amputation should be undertaken. The question of shock and its influence in determining operation is discussed elsewhere. When there seems a reasonable chance of saving the limb, it is cleansed and purified under the strictest antiseptic precautions ; should gangrene supervene, it may be removed later. (ii.) Prolonged pressure is also capable of producing gangrene, such as that which arises from injudicious splint pressure or in the form of bedsores. Splint pressure as a cause of gangrene can only be regarded as an accidental circumstance or the result of carelessness. Where there is a marked tendency to displace- ment of fragments after a fracture, it may be necessary to use some considerable degree of pressure to counteract it, and then in spite of every precaution necrosis of the superficial parts may ensue. Pain of a neuralgic type is usually complained of for a few days, but even that is not necessarily severe enough to attract much attention ; when the limb is freed later on, the dead portion of the skin is white, anaemic, and insensitive. The necrotic process may extend to some depth, and hence the greatest care must be taken to keep the dead tissues aseptic, as otherwise diffuse suppuration may spread along the muscular and fascial planes, and lead to considerable local and constitutional disturbance. Bedsores are likely to occur in patients who are kept for a long time in the recumbent posture, or in any one particular position. The parts most exposed to pressure first become red and con- gested, and finally ulceration or actual gangrene supervenes. As a general rule, bedsores are not very extensive or deep ; but occasionally when the patient is debilitated, and especially if a condition of lowered sensation is present, due to impairment of GANGRENE 81 the nerve-supply, as in paraplegia, the process may extend widely and deeply, destroying fasciae, laying open muscular sheaths, and even leading to necrosis or caries of bones. The spinal canal itself has been opened in this way, and death from septic menin- gitis has resulted. To prevent the occurrence of such sores, the most scrupulous attention must be given to the parts exposed to pressure. The nurse should see that the draw-sheet and bed- linen are placed smoothly and without creases, and that no con- tamination by urine or faeces is allowed ; if the patient is per- spiring freely, the sheet should be frequently changed, so as to prevent decomposition of the sweat. The skin of the back is daily examined, washed with some unirritating soap, and rubbed with a soothing, strengthening, and hardening application, such as spirit of wine, methylated spirit, or perhaps, better still, a mixture of brandy and white of egg. It is then dusted over with a mild antiseptic powder, such as boric acid. If the skin becomes red, it should be painted with collodion, or with a mixture of equal parts of tincture of catechu and liquor plumbi subacetatis, which when dry leaves a powdery film on the surface, and protected from pressure by means of a circular hollow water-pillow. Paraplegic patients or old people should at once be placed on a water-bed, which must be sufficiently, but not excessively, distended. If there is too little water, the weight of the body displaces it to one side, and no good results ; whilst if there is too much, the bed becomes hard and resistant, and fails in the object for which it was employed. When an open sore forms, it must be kept aseptic, and dressed either with boric acid ointment, or in the more sluggish cases with resin and boric acid ointments mixed. Friar's balsam, mixed with castor-oil (i part of the balsam in 8 of the oil), is useful in this condition. (hi.) The action of corrosive or caustic chemicals is followed by a localized traumatic gangrene, the degree of which varies with the amount and character of the irritant present, and the duration of its action. All that is needed is to keep the parts aseptic, and allow them to be absorbed or separated by natural processes. III. Specific or Infective Gangrene. All the forms of gangrene included in this group are charac- terized by their origin in the development of micro-organisms, which by the virulence of their products determine the death of the affected tissues. (a) Acute Spreading, Acute Emphysematous, or Spreading Trau- matic Gangrene. — This disease is one of the most rapidly fatal and serious met with in surgery. Causes. — (i.) The individual attacked is often predisposed to septic inflammatory conditions, as a result of vicious or careless living, or from simple malnutrition. Those who are in the habit 6 S 2 A MANUAL OF SURGERY of consuming large quantities of alcohol, even if not actual drunkards, are especially liable to this affection ; but some forms of virus, which are particularly active, may lead to its development even in a healthy person. It is sometimes seen in diabetics, but an apparent glycosuria occasionally develops in the course of the disease. (ii.) The lesion from which it originates is usually severe, such as a compound fracture or dislocation, especially if the soft parts are much contused or very dirty. Less frequently it originates from small and insignificant pricks, scratches, or abrasions, if thereby a virulent organism gains access to the tissues. In this way post-mortem porters, nurses, or pathological demonstrators may become infected, and the gravest consequences ensue. (iii.) An organism frequently present is the Bacillus of malignant ccdema, first isolated by Koch. It is a rod-shaped microbe, somewhat longer and more slender than that of anthrax. It is anaerobic, and in its growth liquefies gelatine, and produces an unpleasant penetrating odour. On injection into the subcutaneous tissues of a mouse, the animal dies in eight to fifteen hours ; locally, a spreading oedema is produced, the connective-tissue spaces being filled with fluid containing bacilli, and perhaps gas- bubbles. Bacilli are also found in the exudations which occur in the serous cavities, in the connective-tissues of important organs, and in the blood for some time after death. The Bac. pyogenes capsulatus and the Bac. osdematis cevobius are also responsible for this affection. The former is anaerobic, the latter aerobic. Careful investigation of fifty-eight cases* of spreading gangrene resulted in the discovery of the facts that in only fourteen cases was the infection pure, and that with an anaerobic organism ; in forty- four cases the infection was mixed, various septic organisms being present in addition to the gas-producing microbe, which, according to latest researches, is more frequently the Bac. cewgenes capsulatus than the Bac. cedematis maligni. A special feature of infection with the former is the large amount of gas produced, which is found not only in the tissues, but also po3t-mortem in the vessels, and notably in the liver, from which it can easily be squeezed, con- stituting the ' foaming liver ' of some writers. The Symptoms are those of a hyperacute cellulitis, accompanied by general septicaemia. The wound early takes on an unhealthy action, the surface becoming covered with sloughs, and a thin serous or sero-sanguineous discharge escaping. The inflamma- tory process rapidly spreads along the connective-tissue planes of the limb, which becomes swollen, painful, and brawny. At first it is of a dusky purplish colour, but soon the signs of actual gangrene supervene, and the necrotic tissues become crepitant * See Corner and Singer on ' Emphysematous Gangrene,' Trans. Path. Soc. Lond., vol. Iii., 1901, p. 42; Welch's ' Shattuck Lecture,' Philadelphia Med. Journ., August 4, 1900. GANGRENE S3 and emphysematous, partly from simple putrefaction, partly from the gaseous developments associated with the growth of the specific organism. Occasionally the emphysema spreads widely and rapidly, with at first no other local evidence of mischief; sloughing will, however, follow if the patient lives long enough. Evidences of profound toxic disturbance soon manifest themselves, the patient perhaps having a high temperature and being delirious; but not uncommonly fever may be entirely absent, the tempera- ture being subnormal and coma present. The outlook is exceed- ingly grave, death usually ensuing in from five to seven days after the onset. The only Treatment which holds out any hope in dealing with a limb where the disease is rapidly extending is a high amputation, even through the shoulder or hip-joint. Any delay is dangerous, although, in spite of the greatest promptitude, the infection may have progressed so rapidly that death follows from septicaemia, even after the limb has been removed. Perhaps it may be wise to leave the wound widely open for a day or two so as to permit the free discharge of secretions. In a few cases, where the patient is seen early, it has been possible to save both life and limb by freely incising the affected tissues, and immersing them in a continuous warm antiseptic bath. At the same time the general health must be attended to by giving plenty of fluid nourishment, together with diffusible stimulants, such as ether and ammonia. (b) Wound Phagedena and Hospital Gangrene are conditions affecting wounds which were seen often enough in the pre-anti- septic era, but are now practically unknown, thanks not only to antisepsis, but to the increased care directed to ventilation and hospital hygiene. They consisted in a rapidly spreading ulcera- tion or gangrene, which attacked operation wounds a few days after their infliction, and as a rule led to rapid death. It is fortunately unnecessary to describe or discuss them nowadays. (c) Necrosis of Bone is practically always due to the develop- ment of organisms, and may be either acute or chronic. In the former, the inflammatory reaction is so severe that the vessels are strangled within the bony alveoli ; in the latter, it is largely due to an obliterative endarteritis, which accompanies the various specific processes. (See Chapter XVIII.) (d) Cancrum Oris and Noma. — Cancrum oris is an infective gangrenous stomatitis, affecting young children living in squalid surroundings in over-populated districts of large cities. The patients are always in a low state of health, and frequently con- valescing from one of the exanthemata, particularly measles. Various special organisms have been described from time to time as responsible for cancrum oris ; but it appears that any of the many forms found in the mouth may be present, and probably the Streptococcus pyogenes acting in conjunction with various 84 A MANUAL OF SURGERY saprophytic bacilli is the most important. The process starts in an abrasion of the mucous membrane, which, being infected from a diseased or dirty tooth, becomes inflamed and gangrenous. A foul ashy-grey pultaceous slough forms on the inside of one of the cheeks, and from this the most offensive discharge is poured into the mouth and swallowed, the breath in consequence being intensely fcetid. The gangrenous process gradually spreads both superficially and deeply ; the cheek becomes swollen, shiny, and tense, and, should the process extend through its whole substance, a black slough appears on its outer aspect, and gradually increases in size. In the worst cases, the adjacent bones of the face may be affected and die, and the tongue, palate, and even the fauces, may also be involved. The general phenomena are those of a severe sapraemia, since not only are the toxic products swallowed, but they are also absorbed by the lymphatics, and may be inhaled, in the latter case giving rise to septic pneumonia. Moreover, the patient runs a considerable risk of developing pyaemia, from implication of the facial or other veins in the necrotic process, whilst infective septicaemia may also supervene. Rigors and high fever often occur early in the case, but death is usually preceded by symptoms of collapse and coma with a subnormal temperature. The Treatment must be prompt and energetic if the child's life is to be saved. The patient should be at once anaesthetized, and all the pultaceous slough scraped from the interior of the mouth by means of Volkmann's spoon, until healthy bleeding tissue is reached. The denuded surface is then freely rubbed over with pure carbolic or strong nitric acid. If the bones of the face are involved, they must be removed, as also any offending teeth. Afterwards the child should be well fed up, and of course for a time with fluids ; the mouth is to be frequently washed out with antiseptic lotions, such as a solution of sanitas (i in 10), boro- glyceride (i in 20), or permanganate of potash, or with a gargle of chlorate of potash (10 grains to 1 ounce). A mixture containing chlorate of potash, dilute hydrochloric acid, and infusion of cin- chona, may be administered for a few days, and then iron and quinine. In the most severe cases the same treatment should be adopted, even if the whole thickness of the cheek has been en- croached on ; loss of substance must be made good by subsequent plastic work. Necessarily, the cicatrization following this de- structive process results in a good deal of permanent impairment to the movements of the jaw. Noma is the name given to a similar process occurring about the genital organs of children, especially the vulva. The Treat- ment is practically the same, except that here it may be possible to immerse the patient in an antiseptic bath, thereby diluting the toxic products, and possibly preventing the necessity for having recourse to more serious surgical procedures. (e) For Carbuncle and Boil, see Chapter XIV. GANGRENE 85 IV. Gangrene from Thermal Causes. 1. Frost-bite. — This condition is not very frequently seen in this country, but is by no means uncommon in regions where the winter is more severe. It occurs in those who are exposed to the cold, and the symptoms are induced more readily if a high wind is blowing, the heat of the body being thereby more quickly dis- persed. It may originate in one of two ways : (a) From the direct effect of cold on the tissues, which become shrunken, hard, and of a dull, waxy appearance. No pain is experienced in the freezing process, so that onlookers are more likely to recognise the condition than the individual himself. The extremities of the body, where the circulation is a little sluggish, and exposed parts, are chiefly liable to be attacked, and thus the nose, ears, fingers, and toes are most often involved. It is more likely to occur in the young and in old people, whose vita! powers are not very great. Gradually the part shrivels up, turns black, and is either absorbed or separated by a process of ulceration with or without suppuration. The most marked feature of gangrene from frost-bite is the more extensive implication of the superficial parts on account of their greater exposure. (b) From the subsequent inflammation that arises in parts which, though frozen, are not immediately killed. The thawing of such structures is accompanied by the severest pain, and the prolonged anaemia causes such a lowering of the vitality of the vessel walls that the re-admission of the circulation is only too likely to be followed by an acute inflammation, which terminates in necrosis from compression of the vessels by the rapidly-formed exudation. If it escapes actual death, the part remains red, congested, and painful for some time, and superficial ulcers may even develop ; eventually, however, it recovers. Treatment. — The frozen parts must be thawed very gradually, and the blood admitted into the tissues slowly, if inflammatory gangrene is to be avoided. They should be gently rubbed with snow or cold water, and warmed by being held in the hands of the manipulator, whilst the patient should be placed in a cool room, the temperature of which is slowly raised. As reaction comes on, a small amount of warm drink may be cautiously given. Excessive pain or congestive oedema may be limited by elevation of the part. If actual gangrene occurs, the dead tissue must be rendered and kept aseptic, and the case carefully watched until a definite line of separation has formed. 2. Burns and Scalds. — These may be considered as a special variety of wound, not necessarily ending in gangrene, brought about by the action of heat ; burns, either by the close proximity to, or direct contact with, flame or heated solid bodies ; scalds, by the action of boiling water, superheated steam, or other hot fluids 86 A MANUAL OF SURGERY or gases, the difference in the effects being comparable to the dis- tinction between roasting and boiling. Naturally, fluids such as oil, which boil at a higher temperature than water, produce increasingly severe results. The Effects of burns and scalds vary with the source of heat, its intensity, and the duration of its application. Six different degrees of burn were described by Dupuytren, and his classification may still be retained with advantage. The first degree consists merely in a scorch or superficial congestion of the skin, without destruc- tion of tissue ; the part may, however, remain red, painful, and prone to ulceration for a time. Should the scorch be often repeated, as by people constantly warming their legs before the fire, the skin becomes chronically pigmented and indurated (erythema ah igne). In the second degree the cuticle is raised from the cutis, and a bleb or blister results. When this bursts, and the cuticle is removed, the cutis vera, red and painful, is exposed below. In the third degree the cuticle is destroyed, as is also part of the cutis vera, but the tips of the interpapillary processes, including the exquisitely sensitive nerve terminals, are laid bare and left intact ; consequently this is a most painful form of burn. The deeper structures of the skin — viz., the sweat and sebaceous glands, and the hair follicles — remain untouched, so that, although the surface during the healing process becomes covered with granulations, the integument is very rapidly replaced, since there are so many epithelial elements from which it can grow. The cuticle is able to form not from the edge only, as must occur wherever the whole of the cutaneous envelope is destroyed, but also from innumer- able foci scattered over the wound surface. The resulting scar, though often white and visible, undergoes no contraction ; it is supple and elastic from containing all the elements of the true skin. In the fourth degree the whole thickness of the integument is destroyed, as well as part of the subcutaneous tissues. In the fifth the muscles are also encroached upon, whilst in the sixth the whole limb is charred and disorganized. In the last three forms healing can only occur by removal of sloughs and the formation of a cicatrix, which by its contraction may lead to subsequent deformity. The Local History of a burn may be described in three stages, corresponding to the three stages through which an ulcer or a lacerated wound passes : (i) The stage of destruction or burning, the various degrees of which have been just alluded to; (2) the stage of inflammation and sloughing, whereby the dead tissue is removed, and the wound converted into a healthy granulating sore; (3) the stage of repair, which follows the course described elsewhere (p. 209). There are no special characteristics of these processes which call for particular note, except that they are usually of a septic nature, unless the burn is a small one. The skin is usually dirty (from a surgical standpoint) at the time of GANGRENE 87 the accident ; it may be infected from the clothes which are being worn, and immediate attention may be impossible. Moreover, the extent of the lesion and the terrible pain associated with it often render complete sterilization impracticable. The General or Constitutional Conditions which correspond to these three stages require a little fuller notice. 1. As an immediate result of the burning and destruction of tissue, the patient lies for a time in a state of shock, the intensity of which depends not so much on the depth of the burn as on its extent, so that total charring of a limb will probably cause less depression of the system than an extensive superficial scorch, especially if the latter involves the abdomen. It frequently passes into a condition of collapse, due in measure to the absorption of toxic products from the burnt tissues. During this stage the internal viscera, especially those connected with the portal system, become intensely congested. 2. Whilst the separation of the sloughs is being effected, a period of inflammatory fever follows, usually of an asthenic type. Any and every form of internal complication due to sepsis may arise during this stage, which usually lasts from four to fourteen days. Congestion of the brain or lungs is not uncommonly seen, but the gastro-intestinal tract is that, perhaps, most generally and seriously affected. The mucous membrane of the stomach and intestines becomes engorged with blood, leading to vomiting and diarrhoea, whilst ulceration, or even peritonitis, may super- vene. During the later days of this stage a peculiar form of Duodenal Ulcer is liable to occur, although it is admittedly not at all common. Its presence is suggested by pain in the epigastrium after food, perhaps some vomiting, which may be blood-stained, and possibly the passage of a motion containing a good deal of altered blood ; but occasionally the first sign of such mischief is the sudden collapse of the patient, followed by death, with or without peritonitis, owing to perforation or excessive haemorrhage (Chapter XXXII.). The bleeding generally arises from erosion of the superior pancreatico-duodenal artery. The ulcers usually occur in the second part of the duodenum, close to the entrance of the common bile-duct. In appearance they present a cleanly punched-out loss of substance with little or no surrounding inflammation, and their distinct limitation suggests that they are due to the auto-digestion of a distinct arterial area, the vitality of which has been diminished by a preceding thrombosis of the vessel. They probably result from the elimination by the liver of some irritating substance derived from septic or other changes in the burnt tissues which is capable of inducing thrombosis in the structures in close contiguity to the entrance of the bile-duct, or at any rate of producing ulceration. Thus, in a fatal case recently under observation, the post-mortem examination revealed A MANUAL OF SURGERY a patch of well-marked ecchymosis in the duodenal mucosa exactly opposite the orifice of the bile-duct. Obviously, it was the early stage of this condition, and would have gone on to ulceration had the patient lived. 3. When healthy repair is occurring locally, and the parts are kept aseptic, no abnormal constitutional condition should be present, although there may be a certain amount of asthenia or anaemia. Where, however, the wounds are septic and suppurating freely, this tendency will be much more marked, and the patient may develop hectic fever and amyloid changes in the viscera, and finally die of exhaustion. Causes of Death from Burns. — If an individual is burnt to death, the fatal event is usually occasioned by asphyxia from the smoke and noxious fumes of the fire ; shock and syncope from fright may perhaps be adjuvants, especially if the heart is weak or diseased. Within the first few days death results from shock or collapse from toxaemia; in the second stage, from sepsis, internal complications, ulceration of the duodenum, etc. ; in the third stage, from exhaustion or intercurrent maladies. The prognosis in children is always more unfavourable than in adults. Treatment. — In the superficial scorches without vesication, all that is required is the protection of the affected parts, e.g., by dusting them over with boric acid powder mixed with starch. Where blisters have formed, the cuticle should be washed antiseptically and then punctured, so as to allow the contained serum to escape, and then the area should be dusted with boric acid powder, and covered with aseptic wool. Carron-oil (i.e., a mixture of equal parts of linseed-oil and lime-water) is also much used, applied on lint ; it is, however, not an antiseptic, although by adding a small proportion of eucalyptus oil (1 to 10) this can be corrected. Latterly some French authorities have commended the use of picric acid as a dressing in cases of burns where the cutis vera has not been entirely destroyed ; the vesicles are punctured, and then a piece of lint, soaked in a solution of picric acid (20 grains to 1 ounce of sterilized water), is applied to the burnt surface, and over this, in turn, a pad of salicylic or sterilized wool is bandaged. Thus a dry dressing is produced, which may be left in situ for some days, when it is reapplied. We have used this plan, and have been much pleased with the results. Where the burn includes deeper structures, the clothes must be removed with as little dragging as possible, being cut away if necessary ; the damaged tissues are then well bathed with some antiseptic, such as carbolic lotion (1 in 40), and covered up as rapidly as possible with lint soaked in eucalyptus oil or weak carbolised oil (1 in 40). In some cases, where the skin and surface are exceedingly dirty, it is well to anaesthetize the patient, and then to cut away parts which must obviously slough and thoroughly purify the wound, which is covered with protective, and dressed with cyanide gauze, or some such material. GANGRENE At the same time, the general condition of the patient must not be overlooked ; he is possibly in a state of considerable shock, and therefore should be put to bed and covered with warm blankets or rugs, whilst perhaps a little warm stimulating fluid is ad- ministered ; in bad cases an intravenous injection of hot saline solution is advisable, and it may often be repeated with advantage more than once. In the case of children with very extensive burns, it is sometimes useful to put them into a hot bath, to which some eucalyptus oil, if obtainable, has been added ; the clothes are then removed or cut away, and the patient allowed to remain for some time, or until the shock has subsided, in the warm water, which should, if necessary, be replenished. The wounds are then dressed, and the little patient removed to bed. It may be desirable to repeat the immersion at every dressing. When a limb has been hopelessly charred or burnt to the bone, it is useless to retain it, and amputation through the nearest healthy tissues should be undertaken at the first favourable opportunity. When the next stage, viz., that of inflammation and sloughing, has been reached, the only requisite is to keep the parts as free from sepsis as possible, assisting the natural processes of repair by warm moist applications, and snipping away sloughs as they loosen. Generally, attention to the ordinary rules of personal hygiene, and a simple diet, are all the precautions that need be taken. When the stage of cicatrisation is reached, the granulating wounds are treated on general principles. The granulations often become prominent, and stimulating applications, such as touching them with lunar caustic, may be necessary. In large wounds, healing should be assisted by skin-grafting, according to Thiersch's method ; unless some such proceeding is instituted, the wound is likely to become chronic, and healing may be delayed perhaps indefinitely. CHAPTER VI. INFECTIVE DISEASES. Cellulitis. Cellulitis (or, as it used to be termed, diffuse phlegmon) is a disease characterized by the existence of a spreading inflammation of the subcutaneous or cellular tissues, due to the activity of micro-organisms, and running on to suppuration, sloughing, or even to extensive gangrene. Causation. — The one essential is the infection of the cellular tissues with some organism capable of multiplying locally, and of developing toxic compounds, which not only act at the site of inoculation, but are also carried along the lymphatics, and by their absorption into the general circulation give rise to toxaemic phenomena. The entrance of the organisms may result from an operation wound which has been allowed to become septic, or from an accidental breach of surface which has not been rendered aseptic, or even from the slightest graze, prick, or scratch. Deep septic wounds which are not properly drained are amongst the most favourable for the development of this condition, especially if the general health of the individual is bad, if he is suffering from albuminuria or diabetes, or if his surroundings are of an insanitary nature. Wherever much loose cellular tissue is present, inflam- matory phenomena readily supervene owing to the absorption of septic material from neighbouring contaminated structures, e.g., pelvic cellulitis arising from a septic uterus. Bacteriology. — The less severe types are generally due to the Staphylococcus pyogenes aureus or alius, whilst the more severe are caused by the Streptococcus pyogenes, which, as will be stated hereafter, is probably identical with the organism of erysipelas, and in these cases the cellulitis has more of an erysipelatous character. In many instances various forms of non-pathogenic organisms may accompany the above. The most acute manifestation of the disease is usually described as acute emphysematous gangrene (see p. 81). Clinical History. — The symptoms in any particular case necessarily differ somewhat according to the site of inoculation and the virulence of the causative microbes, and hence anything from a localized suppuration to the acutest form of spreading gangrene may result. In a case of moderate severity, due to a INFECTIVE DISEASES 01 prick or abrasion which has become infected, there is often a period of quiescence for a day or two, during which the virus is incubating and the site of inoculation shows but slight signs of inflammation, beyond being a little tender. The patient, though feeling somewhat seedy, is able to continue his work, but is finally obliged to give up, owing partly to the increased pain, partly to his general condition. Fever will almost always be present to a greater or less degree, and in the more severe types one or more rigors occur. Occasionally, however, the tempera- ture is subnormal, owing to the depressing effects of the toxic substances absorbed. The affected part is found to be hot, tender, and infiltrated ; if superficial, it looks red and angry, and feels brawny. The course of the case depends to a very large extent upon the treatment adopted ; if freely incised, the process becomes limited, and although suppuration may occur, there is but little sloughing, and hence repair is readily effected. If, how- ever, it is left, or is merely poulticed, the process rapidly spreads, and may even involve the whole limb, which becomes greatly swollen, cedematous, red, and brawny. Intense pam and sleep- lessness, accompanied perhaps with delirium, form the most prominent symptoms, and these, together with the toxic fever, rapidly exhaust the patient's strength. Finally, suppuration occurs beneath the skin, whilst the cellular tissue sloughs, perhaps the whole of the subcutaneous areolar tissue being thereby destroyed, although the skin only gives way in places. Hence it is often possible to pass a probe between the skin and the deep fascia over a considerable area. Sometimes the inflammation skips a part of the limb, the chief focus of mischief being found at a distance from the original site of inoculation, whilst the intervening portion is but little affected. Occasionally the trouble spreads along the deeper areolar planes, involving muscular bellies, which may be infiltrated with pus or may actually slough. This is most likely to occur when the disease is due to septic inflammation fol- lowing a penetrating wound, such as a gunshot injury or a bad compound fracture. In all these more severe forms the patient runs a considerable risk of developing general septicaemia, or even pyaemia. Treatment. — With the exception of cases of emphysematous gangrene, cellulitis results from the activity of organisms which are readily destroyed, and over which the germicidal properties of the body have considerable control. Hence careful attention to the dicta of antiseptic surgery can prevent its occurrence to a very large extent. Abrasions and small punctured wounds should always be carefully protected, and all penetrating injuries dis- infected, especially if the patient runs exceptional risk of infection owing to his occupation or surroundings. Should inflammatory phenomena supervene, the application of antiseptic fomentations, such as the boracic poultice, may prevent their extension, whilst 92 A MANUAL OF SURGERY the bowels should be freely acted upon and the general health attended to. Failing this, and if there is any tendency for the inflammation to spread, incisions should be made into the brawny tissues, so as to give exit to the serous and irritating discharges ; the wounds thus made are dusted with iodoform and lightly packed with gauze, over which the usual dressings are applied. The object of this is to drain the fluids from the parts by capillary action, and hence an effective junction must be maintained be- tween the gauze drain and the surrounding dressing. It is often wise to incorporate a piece of mackintosh in the outer folds of the dressing, so as to keep the parts moist and encourage a free dis- charge. Under such a regime sloughing may be entirely pre- vented, or, at any rate, limited. At the same time the patient's health and strength must be maintained by the administration of suitable food and stimulants, whilst quinine is very useful internally. Another excellent plan of treatment is to immerse the wounds, after freely incising the infiltrated parts, in a continuous warm bath, by this means diluting the toxins to such an extent as to render them innocuous. Warm water does perfectly well, although it may be boiled before use with advantage. Antiseptics are practically useless in checking the disease when once started ; the surgeon has to depend mainly on relief of tension, the removal of toxic discharges, and the antiseptic power of the tissues. At the same time the utmost care must be taken to prevent fresh infection of wounds or decomposition of discharges. Antistreptococcic serum (p. 99) has also been employed as a curative agent with a view to destroy the streptococci and immunize the system to their further development, but the results hitherto obtained have not been very encouraging. The dose varies from 5 to 10 c.c. (1 c.c. = fl\_ i£), injected two or three times a day beneath the skin of the back or abdominal wall. Special Varieties of Cellulitis. Cellulitis of the Axilla not unfrequently follows an infected wound of the hand, such as occurs in the post-mortem room, and hence is not uncommon in medical practitioners, students or nurses. It may also be caused by extension from a primary axillary lymphadenitis. The tissues of the armpit become hard and brawny, the pain is severe, and the disease is liable to spread towards the chest walls under or between the pectoral muscles ; it may also travel upwards, and lay open the shoulder joint from sloughing of the capsule, and so give rise to an acute arthritis. Extensive incisions are required in order to prevent such complications, but respect must be paid to the important vessels and nerves contained in the cavity. Submammary Cellulitis is usually due to an extension of inflammation from the deeper parts of the breast, or perhaps from the cartilages or bones of the chest wall. The areolar tissue beneath the breast becomes infiltrated and ' brawny, and the gland itself is lifted up, and somewhat swollen and tender. (See Submammary Abscess.) Free incisions must be made into the infected area along the lower portion of the circumference of the organ. INFECTIVE DISEASES 93 Cellulitis of the Scalp results from a septic wound which has traversed the occipito-frontalis aponeurosis, and opened up the subjacent layer of loose areolar tissue. Suppuration extends to the limits of attachment of this structure, and hence abscesses are likely to point in the forehead just above the eyebrows, over the zygoma, or along the superior curved line of the occipital bone ; in addition to the severe general disturbance, the patient runs a risk of necrosis of the skull and of various intracranial complications. Cellulitis of the Orbit is not an uncommon sequela of penetrating wounds in this region, owing to the difficulty of rendering them aseptic and of draining them. The whole of the orbital tissues become infiltrated and swollen, the lids are cedematous, and the eyeball is thrust forwards. There is a considerable likelihood of the inflammation spreading to the meninges, owing to the dura mater being continuous with the orbital periosteum through the foramina by which the nerves and vessels enter. Necrosis of the orbital walls may also occur, whilst the eye itself may suffer either from an infective panophthalmitis due to lymphatic infection, or from optic neuritis secondary to retro-ocular inflammation and pressure, or at a later date from optic nerve atrophy secondary to cicatricial contraction around the nerve. If the cellular tissue of the orbit sloughs, the subsequent movements of the globe may be much hampered, or indeed lost, whilst the lids may be drawn back to such an extent as to prevent their complete closure. Treatment. — No penetrating wound of the orbit ought to be closed if there is any question of its infection ; indeed, it is often wise to slightly increase its size, so as to enable the deeper parts to be cleansed. Drainage must always be provided for, and in many cases this is best accomplished by stuffing it lightly with gauze. If cellulitis follows, the original wound must be opened up, and possibly fresh incisions made either through the lids or through the fornix conjunctivas. Antiseptic fomentations or poultices are then applied. If panophthalmitis supervenes, the eyeball must be incised crucially ; this is a safer proceeding than enucleation, which is more liable to be followed by meningitis. Submaxillary Cellulitis, or, as it is sometimes termed, Ludwig's Angina, from the name of the surgeon who first called attention to it, is an infective inflammation of the cellular tissue beneath the deep cervical fascia which occurs in elderly and weakly individuals or in children, without, as a rule, any apparent reason, although probably it spreads from some buccal focus. It occasionally results from inflammation extending beyond the capsule of glands, and may originate in disease of the middle ear, the mischief travelling downwards along the digastric muscle. It commences as a brawny induration in the submaxillary 'region, which is tender, painful, and hot; there is a certain amount of fever, and this increases pari passu with the extent of the area inflamed ; it tends to spread to the front of the neck and base of the tongue, even causing the latter to protrude from the mouth. Dangerous symptoms arise from pressure on important vessels and nerves, from extension of the inflammation to the glottis, causing cedema and consequent dyspnoea, or from the supervention of pyaemia owing to venous thrombosis. The process usually ends in sloughing of the cellular tissue and suppuration, the pus burrowing widely if a free exit by incisions through the deep fascia is not provided ; occasionally a large sublingual abscess may form, causing the gravest constitutional and respiratory disturbance, whilst in rare instances the mass may remain stationary and indurated for a considerable time. The Treatment must be prompt and energetic; a free incision is made through the median line into the midst of the brawny tissue, or along any line of safety where pus is threatening to form. A sublingual abscess may be opened from the mouth ; but it is better, if possible, to do so from below, so as to exclude sepsis. Prior to suppuration, fomentations may be used, whilst tonics, stimulants, quinine, and plenty of good food are needed. Pelvic Cellulitis arises from extension of inflammation from the pelvic viscera to the loose cellular tissue ensheathing them. It may be due to lymphatic absorption from septic material contained in the uterus, or it may 94 A MANUAL OF SURGERY spread from the ovary, Fallopian tube, or prostate. Injuries to the bladder or rectum may also light up the trouble. It is associated with all the "local and general signs of deep inflammation, and often, indeed, with peritonitis, giving rise to a tense, firm, painful swelling to be felt per vaginam or per rectum, and sometimes to an indurated mass of inflammatory effusion, dull on percussion, above the pubic arch. Abscesses may form in this effusion, bursting either externally or into some of the viscera, or possibly in both directions, producing very intractable forms of urinary or faecal fistulae, whilst venous obstruction and pyaemia are very likely to develop. The surgeon may be called on to deal with such cases either in the early pre-suppurative stage, when rest, limitation of diet, small doses of opium, and fomentations to the hypogastrium, conjoined perhaps with hot antiseptic vaginal or rectal douches, should be adopted ; or at a later date, when pus has formed and the abscesses need to be opened. An incision is generally made just above Poupart's ligament and close to the pubic spine; the abdominal muscles are divided to a sufficient extent to enable the surgeon to work down- wards between the transversalis fascia and the peritoneum, which must be pushed aside in order to reach the broad ligament, where pus is frequently found. As soon as the subperitoneal tissue is opened, the knife should be dis- carded, and only blunt instruments or the fingers employed. The cavity of the abscess should be well washed out and efficiently drained, and possibly a counter-opening through the vagina may be required. Intestinal obstruction may develop as a remote sequela from the contraction of cicatrices, and hydronephrosis may arise in the same way from pressure on the ureter. Erysipelas. Erysipelas is a specific and contagious infective disease due to the development of the Streptococcus erysipeloids (Fehleisen) in the smaller lymphatics of the skin and occasionally of mucous mem- branes, with a decided tendency to spread and to recovery without loss of tissue, the constitutional symptoms being due to the absorption of toxins developed locally. Occasionally the sub- cutaneous connective tissue is also involved, constituting the variety known as cellulo -cutaneous erysipelas. There has been considerable discussion as to whether there is any difference between the erysipelas microbe and the ordinary Streptococcus pyogenes found in spreading suppuration. The microscopical characters are indistinguishable, and the growth in various reagents is very similar. Inoculation experiments, "moreover, certainly seem to indicate that they are closely allied species, and the majority of bacteriologists consider them to be identical, the differing effects depending merely on the methods of inoculation and the virulence of the particular organism. The chief objection to this theory is the great difference which exists between the ' infectiousness ' of erysipelas and cellulitis. No surgeon can complain of the presence of the latter in his wards , none permit the presence of the former, except on compulsion. The Causes of erysipelas may be briefly stated as follows : (i.) The existence of an abrasion or wound in most cases, and particularly of an unprotected septic wound. Thus, it is not uncommon to find it associated with neglected scalp wounds or INFECTIVE DISEASES 95 with those communicating with the mouth. (ii.) A weak, depressed state of the constitution, as from alcoholism, vicious living, diabetes, albuminuria, etc. Some people, moreover, seem naturally predisposed to the disease, particularly plethoric and gouty individuals, and one attack renders the subject more liable to recurrence after a short period of immunity, (iii.) Bad hygienic surroundings are a most important additional factor in its produc- tion, especially overcrowding in hospitals and bad ventilation. But these are all merely predisposing conditions ; the only ex- citing and absolute cause is (iv.), the infection with the specific micro-organism, which is very widely diffused in Nature. An idiopathic form used to be described, in which the disease starts without any apparent local origin; but when one considers that infection may occur through the slightest abrasion, and even through sound skin or mucous membrane, and that the cocci do not exist, as a rule, in the blood, it is evident that the theory of local infection is in all cases the more probable. When once an entrance has been effected, the cocci develop in the superficial lymph channels, producing a transient inflammatory condition of the skin, and a concurrent pyrexial state of the individual from the absorption of specific toxins. The Symptoms of the disease are usually ushered in by a slight chill, scarcely amounting to a rigor, and by a period of headache and malaise for about twenty-four hours, with some degree of pyrexia. These symptoms are followed by the development of a bright, rosy-red rash, spreading either from the margin of the wound, or showing itself in apparently unbroken skin in the so-called idiopathic variety. If there is a wound, it usually presents a yellowish, unhealthy-looking surface, with very little evidence of repair. If the erysipelatous virus is unmixed with other organisms, the healing process may continue until the rash appears, about the fourth or fifth day, when the young cicatrix will break open again, exposing a dry and sluggish surface, with a thickened margin ; it may occur, however, at an earlier date. The rash is generally of a characteristic vivid red colour, always disappearing on pressure, and is accompanied by a sensation of stiffness or burning, scarcely amounting to pain, except when dense structures, such as the scalp, are involved, and then the pain may be very severe. Swelling is not very marked, except in lax areolar tissues, such as in the scrotum or eyelids ; the oedema may then attain considerable proportions. The rash continues to advance more or less rapidly, with a continuous margin, and as it spreads to new regions it fades away from those already involved, leaving a slight brownish stain and a fine branny desquamation. In some cases it does not spread evenly, but appears to leap over an interval, and then the intervening lymphatics are found to be thickened. Vesicles and bullae form superficially, containing serum, which speedily becomes turbid, but suppuration is un- 96 A MANUAL OF SURGERY common, except in lax oedematous tissues, such as the eyelids, Occasionally, from the severity of the inflammation or the low state of vitality of the tissues, the skin may become gangrenous and slough, especially about the umbilicus and genitals of young children. Neighbouring lymphatic glands are always enlarged and painful, and this may even be noted at a period when the rash has not appeared. Periphlebitis may also be caused, leading to pyaemic complications. Fever is present as long as the rash persists, and merely shows slight diurnal variations. It is not uncommon for the temperature to rise to 104 F., but anything above that is of grave significance. At first the fever is of a sthenic type, the pulse full, and the delirium noisy and active ; but later on the pulse becomes quick and weak, accompanied by low, muttering delirium and great prostration of the vital powers. Delirium is usually a well-marked feature in erysipelas of the scalp, but this is due to the general rather than to any local condition, unless meningitis supervenes. The duration of the attack is most variable, lasting, as a rule, from one to three weeks, but relapses are not uncommon. The so-called Idiopathic Erysipelas mainly affects the head, and occurs in predisposed individuals ; it is characterized by the great oedema of the subcutaneous tissues of the face, which causes the features to become almost unrecognisable. Large blebs form, and even abscesses about the eyelids. There is a great tendency to recurrence about the same time of the year in these cases, and pain and delirium are prominent symptoms. Cellulo-cutaneous Erysipelas is due to an infection of the skin and subcutaneous tissues with the specific virus, and results in suppuration and sloughing both of the skin and subjacent cellular tissue. The signs are those of a diffuse spreading inflammation, e.g., heat, pain, redness, and swelling of a brawny type at first, but which soon softens and becomes boggy, the skin giving way, and allowing exit to the pus and sloughs. The general symptoms are correspondingly severe, and pyaemia may also be present. As distinguishing features from ordinary erysipelas, it is stated that the margin of the redness is less defined, that the lymphatic glands are less enlarged, and that it is doubtful whether or not the disease is contagious ; the whole nature of this affection is still more or less sub judice. Erysipelas of the Fauces causes a diffuse inflammation of the mucous membrane of the fauces, often spreading to the glottis and larynx, and arising either by extension from without, or in association with some external manifestation of the disease else- where. The fauces and soft palate become of a dusky scarlet colour, and are much swollen. The voice is either husky or absolutely disappears, whilst severe spasmodic dyspnoea may arise from the oedema extending to the glottis. The parts are very prone to ulcerate or slough, and the glands at the angle of INFECTIVE DISEASES 97 the jaw are enlarged. Fever is usually, though not invariably, present, and great depression of the vital powers. Erysipelas of the Scrotum, or, as it is sometimes termed, acute inflammatory oedema, is characterized by the part becoming greatly distended by serum, but without any marked redness. Suppuration and sloughing are not unlikely to follow. It thus somewhat simulates the appearance produced by extravasation of urine, but is distinguished from it by the facts that micturition is usually not interfered with, and that the swelling is not limited in the same way as in the latter affection. Diagnosis. — There is not much difficulty in recognising a case of erysipelas if we remember the distinguishing features of the rash, viz., its method of extension by a broad, sharply-defined, slightly raised and infiltrated red margin. Thus, the exanthemata are never limited to one part of the body, and rarely form one continuous red patch. Lymphangitis is characterized by streaks or lines of redness, not by an area of uniform hyperaemia. In phlebitis the skin is seldom red over the inflamed vein, which can be felt as a hard knotted cord below. A septic wound with pent-up discharge closely simulates erysipelas ; but the margin of the redness is not so accurately defined, and lymphatic enlargement does not so constantly occur. Diffuse erythema nodosum is recog- nised from it by the slight degree of the febrile disturbance, and the presence of outlying patches of redness, which, moreover, are not so clearly limited. There is always considerable pain in this affection, which often involves both legs, and usually occurs in young women of a rheumatic temperament. The so-called erythema solare follows exposure to the sun's rays, especially when reflected from water, of parts of the body which are, as a rule, protected ; though usually of slight importance, it may some- times give rise to so much pain, cedema, and constitutional disturbance as to simulate erysipelas. It is readily distinguished by the facts that it is limited to the parts exposed and has no tendency to spread. In acute eczema ruhum the presence of a honey-like exudation is quite characteristic. Pathological Anatomy. — If a person dies of erysipelas, one merely finds the general signs common to all septic cases detailed elsewhere (p. 7). The rash will have faded, but on microscopic section of the skin colonies of cocci arranged in chains will be found invading the lymphatics just beyond the spreading margin (Fig. 10), whilst in the parts which the inflammation has recently attacked there will be a considerable excess of leucocytes, pre- sumably connected with the destruction and removal of the cocci. The lymph glands will also be found enlarged and congested. Prognosis. — Erysipelas is not peculiarly dangerous in itself (Osier gives the death-rate as 7 per cent, in hospital patients), but may become so from the complications which attend it. The most important of these are inflammatory conditions of the brain, 7 A MANUAL OF SURGERY lungs, and other viscera, especially of the kidneys. Pyaemia and general septic intoxication are also met with. Erysipelas is usually attended with danger to life in old people, drunkards, and infants, whose vital powers become rapidly exhausted. As a local complication, erysipelas is not always an unfavourable occurrence, since wounds which have become chronic and sluggish will sometimes manifest marvellous reparative power after an attack. Chronic lupoid and syphilitic ulcers may rapidly cicatrize, and even malignant sores, especially sarcomata, have been known to be cured. The Treatment of erysipelas is mainly conducted on general principles. Prophylaxis must be strictly attended to by observing every antiseptic detail in the treatment of wounds, especially if any erysipelas cases are under treatment at the time. When the disease is prevalent, all operations that can be delayed should be Fig. ii. — Section of the Spreading Edge of a Patch of Erysipelas, showing the lymphatics occupied by chains of cocci, which as yet have produced but little effect on the tissues. postponed. Single cases should be isolated, and kept out of surgical wards if practicable. If, unfortunately, a case develops in the wards, and cannot be completely isolated, the bed should be placed as far away from others as possible, and especially from those with open wounds which from their position (e.g., the mouth) cannot be properly protected from sepsis. It is usual to surround the bed with sheets kept moist with carbolic lotion, and the floor around should be sprinkled with the same. Special nurses must be told off to attend to the case, and house-surgeons and dressers must take extra precautions to prevent the spread of the disease. Local Treatment. — When one considers the bacterial origin of the affection, it is evident that, except in the mildest cases, the old-fashioned plan of merely protecting the part from the air, as by painting it with collodion, or covering it with a thick layer of starch or flour, mixed perhaps with boric acid, was very inefficient, whilst it is equally obvious that the local application of cold is INFECTIVE DISEASES 99 absolutely harmful, as tending still further to depress the vitality of the part. Where tension and pain are severe, fomentations containing opium or belladonna (e.g., 1 ounce of laudanum to 1 pint of lotio plumbi) may be applied, or the parts should be scarified and antiseptic compresses applied, e.g., gauze soaked in carbolic acid (1 in 30) or in sublimate solution (1 in 1,000). Perhaps the best local applications are ichthyol or thiol, the latter being an artificial sulphur compound much resembling ichthyol, but without the objectionable smell. A 20 to 40 per cent, aqueous solution is painted over the affected area, possibly after scarification, as well as over the neighbouring healthy skin several times a day until the fever disappears; such treatment is stated to be usually successful in checking the disease in two or three days, whilst the stickiness of the preparation hinders the diffusion of the virus. Pressure may be of some value in limiting the spread of the mischief, probably by compressing the lymphatics. A wide band of adhesive plaster wound around a limb beyond the margin of the rash is often effectual, and it may be possible in this way to check its advance from the scalp to the face or neck. Anything that tends to produce a local accumulation of leuco- cytes in the skin beyond the spreading edge should be beneficial in checking its advance, and therefore good may be derived by painting around the rash with strong solutions of nitrate of silver or with lin. iodi, granting that it is done sufficiently far off to be on healthy skin. The most efficient plan based on this idea is Kraske's, in which the skin is scarified all round at a distance of an inch or two, the knife going just deeply enough to draw blood ; antiseptic compresses are then applied. An antistreptococcic serum,* prepared by immunizing a horse with the Streptococcus pyogenes, and then withdrawing its blood serum, has been used a good deal, especially in France, where Marmorek and others have elaborated this plan of treatment. Ten or fifteen c.c. of this serum are given subcutaneously as a dose, and repeated once or twice a day. In favourable cases the pain rapidly diminishes, the rash ceases to spread, the temperature falls, and in twenty-four to forty-eight hours the disease may be at an end ; but this result is not always obtained, possibly owing to some defect in the preparation of the serum. Constitutional Treatment must be of a tonic and supporting character. Good food, easy of assimilation, stimulants and quinine should be freely administered, whilst the tincture of the perchloride of iron in -^-drachm doses, repeated three or four times a day, is still looked on by many as a specific. In cellulo -cutaneous erysipelas early and free incisions must be made to relieve tension, and, if possible, anticipate suppuration. * Obtainable at a few hours' notice by telegraph from the Jenner Institute of Preventive Medicine, and many large chemists. A MANUAL OF SURGERY The tissues, when incised, look gelatinous from the oedema present, and much fluid of a seropurulent type will escape. If this is not undertaken, considerable portions of skin and sub- cutaneous tissue may slough. Antiseptic poultices should be employed after the incisions have been made, until granulations have developed. In erysipelas of the fauces the parts must be painted or freely sprayed over several times a day with antiseptic lotions, such as liquor argenti nitratis (10 grains to i ounce), liq. hydrarg. perchlor. (i in 2,000), or liq. soda? chlorinatae (1 part to 15 parts of water), whilst tracheotomy may be needed if the glottis is involved. Diffusible stimulants and plenty of nourishment are urgently necessary to combat the depressing effects of this disease. Septicaemia. Septicaemia is an acute general infective disorder, arising from the development of some variety of pyogenic organism in the blood. It differs from pyaemia in the absence of secondary abscesses (although, as explained later, it may be associated with it), and from sapraemia or septic intoxication by the fact that the latter is merely a chemical toxaemia. In septicaemia, if a comparatively minute trace of the blood taken at a distance from the local focus of mischief is inoculated into another animal or individual, the disease is almost certainly transmitted, and often with increased virulence ; in sapraemia, injection of the blood, except in large quantities, does no harm. As to the ultimate cause of septicaemia in man, much discussion has arisen owing to the divergence of the results obtained by experimental research. Koch and Davaine succeeded in isolating bacilli which produce fatal septi- caemia in rabbits and mice respectively ; but neither of these is necessarily pathogenic to other animals, and neither is the same as the organisms usually found in human septicaemia, although the symptoms are practically identical. In man various bacteria seem capable of producing this disease under suit- able conditions — viz., the ordinary Streptococcus pyogenes of acute spreading suppuration ; the Streptococcus septicus of Fliigge, which is probably identical with the above, though more active ; the Streptococcus septopy 'amicus, which is more nearly allied to the erysipelas organism ; or even the Bacillus of malignant oedema (Koch). If a mouse is infected with its specific bacillus, it remains apparently un- affected for a period of twenty-four hours (incubation stage), but then becomes languid, its eye loses lustre, it refuses to eat or run about, the respirations become slower, and in about another twenty-four hours it dies, all its functions appearing to be more or less paralyzed. Anatomically, one discovers but few naked-eye changes, except a little local inflammatory exudation at the point of inoculation, and slight swelling of the spleen. Microscopically, many of the red corpuscles are found to be invaded and broken up by bacilli which may even be seen within them, and the capillaries, especially in the lungs, are more or less blocked by aggregated masses of organisms. The pathological processes in human septicaemia are inferred to be of a INFECTIVE DISEASES similar character — viz., development of organisms in the blood, with dis- integration of corpuscles, especially of the red ; obstruction to capillaries, particularly in the lungs ; formation of toxins as a result of this development ; and paralysis of the functions of the nerve centres thereby. Clinical History. — Septicaemia occurs most commonly from direct inoculation with suitable organisms through small lesions, such as post-mortem wounds, or from scratches or punctures with infected pins or instruments ; it also in rarer cases follows operation wounds and severe lacerated injuries. It is the usual accompaniment of acute spreading gangrene, and may be met with in cellulitis and cancrum oris. As a rule, the individual attacked is in a depressed and debilitated condition, often deterio- rated by alcoholic or other excesses, so that the inherent germi- cidal activity of the tissues is markedly insufficient to cope with the inroads of the disease. The point of inoculation may be the seat of any of the forms of local trouble which we have already described under the title of cellulitis, and this may vary from a mere slight inflammatory blush to the acutest form of spreading gangrene. The General Symptoms are those of fever, often ushered in by a distinct and severe rigor ; the temperature reaches 104 or 105 F., and usually remains high, with but slight remissions and no intermissions. Malaise is present, with loss of appetite ; the tongue is brown and parched, the pulse quick and feeble, whilst the skin has often a slight icteric tinge. Diarrhoea usually ensues, and may be blood-stained, whilst the urine is albuminous, and contains blood. Petechias appear under the skin, and the patient, after a period of delirium, becomes comatose, and dies. Dyspnoea sometimes precedes the fatal issue, whilst the temperature may be exceedingly high, or occasionally subnormal ; the association of a low temperature with a very rapid pulse is always of grave import. Illustrative Cases. — A servant-girl, aged about twenty-two, complained one hot summer's day that she had been stung near the inner canthus by a fly ; possibly the insect had come from some infected material, and thus poisoned the wound. In twenty-four hours she was feeling ill and feverish, and had some chills and flushes; a painful swelling developed at the inner canthus, which rapidly increased in size and spread downwards. At the end of four days, when we saw her, the eye was protruding and much congested, and a definite band of inflammatory thickening could be felt reaching from the roof of the nose across the face to the neck and jugular region, probably the throm- bosed facial vein, the clot doubtless extending to the cavernous sinus. The temperature was high, and the girl was delirious. An incision was made into the orbit with the view of relieving tension and giving exit to any pus that might be present, but with no result. She rapidly became unconscious, and died within a week. An elderly man, addicted to drink, fell in the street, and grazed the inner side of his hand. Within twenty-four hours the whole arm was puffy and swollen, and in two days gangrene had manifested itself, the infiltration reaching beyond the shoulder. The patient was dead from acute septicaemia in five days. A MANUAL OF SURGERY The Post-mortem Signs are those found in all cases of acute septic poisoning, described above (p. 7), with the addition that on microscopical examination bacteria can be demonstrated in the blood and internal organs. The Diagnosis has to be made from the more virulent forms of the acute exanthemata, in which the patient is destroyed before the characteristic appearances are manifested ; in such cases a definite opinion as to the nature of the affection is often impossible, if there is no clue as to the origin of the infection. Saprcemia is always associated with some very obvious focus of putrefaction, whilst septicaemia may occur with but slight local manifestations. Septic traumatic fever, due to wound infection, may be so severe as to cause grave anxiety for a time as to whether or not septicaemia is present ; but if the wound is freely opened up and drained, the rapid disappearance of the fever proves that the mischief was merely a local, and not the more serious general, affection. From pycemia it is known by the absence of repeated rigors and secondary abscesses. The Prognosis of septicaemia is always very grave, but it is to be hoped that the modern plans of treatment mentioned below, especially serotherapy, may prove beneficial in diminishing the mortality. The Treatment consists in dealing actively with any local focus of inflammation, either by amputation, or by free incisions, purifi- cation, and drainage ; but unfortunately this is seldom likely to be successful, as blood infection has probably already occurred. In addition to such means, tonics and stimulants, with plenty of suitable nourishment, must be administered. It is possible that even this grave disease may become amen- able to some of the therapeutic measures which have been sug- gested of recent years. Thus, the antistreptococcic serum (p. 89) may be utilized, and cases have been already reported as cured by its agency. Another plan which has been adopted is that of the intravenous injection of considerable quantities of normal saline solution, repeated two or three times a day ; by this means diuresis and diarrhoea are induced, and it is hoped that thereby the organisms and their products may be eliminated. This treatment has, however, been introduced so lately that no dogmatic state- ments can be made about it ; it will probably be of greater value in cases of sapraemia than in those of true infective septicaemia. INFECTIVE DISEASES >03 Fig. ii. — Disinte- grating Clot lying in a Vein in Pyeemia. Pyaemia (Greek ttvov, pus, and aifxa, blood) is a disease charac- terized by fever of an intermittent type, associated with the formation of multiple abscesses in different parts of the body, arising from the diffusion of pyogenic materials from some spot of local infection. It was supposed not long ago that pyaemia was due to some specific micro-organism, but it has now been definitely proved by Rosenbach that any of the pyo- genic organisms can give rise to it ; in fact, theoretically, pyaemia may arise as a complication following any acute abscess, which, as we have already seen, is always due to bacterial activity. As a rule, however, there is a sufficiently rapid development of granula- tion tissue to limit the spread of infection. The organism most commonly found is the Streptococcus pyogenes, but in a few cases the Staphylococcus pyogenes aureus has been observed. The mere injection of cocci into the circulation is not sufficient to give rise to pysemia; if they are few in number, a transient a'caskof'Pyamia Py rexia ma Y .supervene, and then the germicidal fTii manns \ " P ower£ latent in the blood destroy them ; but if the * ' dose is large, or the individual is not in a very re- The apex of the clot sistant condition, septicaemia, and not pyaemia, results, projects into a larger unless special conditions are present which determine trunk, in which cir- the formation of embolic abscesses. If the cocci to culating blood is be injected are mixed with such a material or aggre- present, and from it gated into such masses that the organisms are carried infected emboli on particles too large to pass through the terminal would be detached, arterioles and capillaries, wherever they lodge abscesses develop. In human pathology the infective emboli consist of zoogloea masses of organisms, or of infected particles of disinte- grating blood-clot (Fig. n). The Cause of pyaemia may be stated to be any condition which leads to the formation and detachment of infective emboli in the circulation, such conditions occurring mainly in the veins from infiltration and disintegration of a thrombus (infective phlebitis), but occasionally in the heart (malignant endocarditis). The venous contamination which was formerly so much dreaded after opera- tions by surgeons has now been practically banished from surgery by antisepsis ; but the disease is still occasionally met with in casualty work, where efficient asepsis is difficult. Acute infective inflammation of the cancellous tissue of bones, whether idiopathic or traumatic, is very commonly associated with pyaemia, owing to the veins being abundant and thin-walled, and considerable tension present from the unyielding condition of the surrounding bony structures. Inflammation of the cranial bones coming on in the course of middle-ear mischief, and causing thrombosis of the lateral sinus, also leads to its development. The presence of large open-mouthed veins in the puerperal uterus also explains io4 A MANUAL OF SURGERY the onset of the disease after parturition if septic material is allowed to collect or remain in their vicinity. When an infective embolus lodges in any region of the body, a thrombus forms upon it, and in this the micro-organisms rapidly develop, and thence pass through the vessel wall into the sur- rounding tissues, causing inflammation, which is at first of a plastic type, but later on becomes suppurative. In the lung many such foci may occur, distributed mainly along the posterior border and near the surface ; each is sharply limited to a wedge- shaped area of tissue, with the base directed towards the periphery. It is at first reddish in colour, from effusion of blood (a hemorrhagic infarct), but soon becomes greyish -yellow, from the formation of pus. These abscesses are small, and rarely give rise to any physical signs. Similar collections of pus, preceded or not by an infarct, may be found in any organ of the body. The lungs, acting as a filter to emboli derived from the systemic veins, are naturally the first organs to be affected, and from the abscesses formed therein, infection of the arterial system may take place, resulting in fresh suppurative foci in the liver, spleen, kidneys, brain, and in or around joints, etc. If, however, the causative phlebitis is situated in the portal area, the emboli are lodged primarily in the liver, giving rise to what is known as pylephlebitis. When the emboli are many in number, the symptoms are severe, constituting acute pyaemia; this is sometimes associated with a development of micro-organisms in the blood, producing pyosepticamia, the patient perhaps dying before the secondary abscesses have fully developed. In other cases the general symptoms are due rather to the absorp- tion of toxins from the local foci than to the development of organisms in the blood. If the emboli are few in number, and there is little or no development of -microbes in the blood, the disease is termed chronic pyaemia. Clinical History. — The most marked symptom indicating the onset of a case of Acute Pyaemia is the occurrence during a period of febrile disturbance of a severe rigor, which is repeated with a sort of irregular periodicity, most frequently at intervals of about twenty-four to forty-eight hours, somewhat simulating an attack of ague. The rigors do not differ from those occurring in other diseases, but they are very severe, and usually followed by profuse sweating. Between the rigors the temperature may fall to the normal, but more commonly remains above it. The skin is hot and soon develops an earthy or dull yellow tint, together with erythematous or petechial patches. A sweet, mawkish, hay-like smell of the breath is very characteristic. Symptoms of grave depression supervene, and the patient rapidly wastes. The pulse becomes soft and weak, the excretions are diminished, and a certain amount of nocturnal delirium is noticed, but no loss of consciousness. The presence of a bruit in the precordial region may suggest the existence of an infective endocarditis, which is Infective diseases 105 not very uncommon. The tongue varies, but is often red with very prominent papillae, and becomes dry and brownish. Towards the end of the first week secondary abscesses appear ; they are sometimes unaccompanied by local pain or tenderness, and form very rapidly ; thus, a knee-joint may fill with pus in the course of a night of quiet sleep. They are, as a rule, small and numerous ; if they occur in vital organs, death may result from their local development. When situated in the subcutaneous tissues, they are characterized by the almost total absence of a barrier of granulation tissue, and hence, even when opened early and aseptically, are likely to extend and continue secreting pus, instead of following the usual course of rapid contraction and repair which succeeds the aseptic opening of an ordinary acute abscess. Not uncommonly in these cases painful patches occur here and there in the subcutaneous tissues, accompanied by hyperaemia, which fades away after a few days ; such are probably due to the impaction of small infective emboli, which the patient has sufficient vitality to get rid of without suppuration. In Chronic Pyaemia the febrile symptoms are much less marked ; the abscesses are few in number, and not dangerous unless form- ing in important structures. Thus, a fatal result ensued from a single abscess which developed in the lateral ventricle of the brain of a patient who had no other symptom of pyaemia except an oscillating temperature : it followed an operation on a septic sinus leading to a kidney already disorganized. The condition of the wound at the onset of pyaemia is always very unsatisfactory. It gapes open and presents an inactive surface, and any newly-formed scar tissue readily breaks down. A layer of healthy granulations is an almost certain barrier against the occurrence of pyaemia, on account of the germicidal power of the cells constituting it. If the disease arises in connection with bone, the latter structure is usually seen lying bare at the bottom of the wound, denuded of its periosteum, and the cancelli filled with sloughy foetid medulla, or pus. The duration of a case of pyaemia is very variable. Acute cases usually last a little over a week, whilst the subacute forms may run on for three or four weeks, and chronic cases continue for months, and not unfrequently end in complete recovery. Post-mortem Appearances. — 1. The wound is unhealthy, the surface being grey, dry, or sloughy ; if bone is implicated, as in an amputation or excision, evidence of inflammatory mischief, either of the periosteum or medulla, is present. 2. The veins leading from the wound may be in a healthy condition, but are more commonly in a state of septic phlebitis ; the coats are thickened, and the lumen is filled with soft, disintegrating clot, which extends for a considerable distance; the tissues surrounding the vein are also involved in the suppurative process. 3. Secondary io6 A MANUAL OF SURGERY abscesses are found in various parts of the body, most frequently in the lungs, and their different stages can be clearly demonstrated from the embolic colonies of micrococci, through the stage of haemorrhagic infarction to the complete abscess. The contained pus may be of the normal type, or thin and oily ; it is always, however, swarming with cocci. 4. The general signs common to all cases of septic poisoning (p. 7) will also be manifest. The Diagnosis of pyaemia should not be difficult in the majority of cases ; but when it originates without any obvious external wound, as in a deep-seated abscess, or if the importance of some local lesion has not been appreciated, the initial symptoms may be mistaken for those of acute rheumatism or ague. The Prognosis depends upon the inherent vitality of the patient and the virulence of the disease. In acute cases it is extremely grave, whilst in the chronic type recovery is not only possible, but probable, if the local abscesses are favourably situated. In the Treatment of acute pyaemia the surgeon is acting at a considerable disadvantage, in that the disease is only recognisable when it has obtained some hold upon the patient, since the recur- rent rigors, by which it is known, are usually the evidence of a grave general infection of the blood. Local Treatment is most important, and since the disease is in the majority of cases due to the detachment of infected emboli from a vein, the ideal surgical practice consists in preventing, if possible, the further contamination of the general blood-stream. This can sometimes be accomplished, in the case of a limb, by amputation well above the local lesion ; or if the medullary cavity of a bone is the source of trouble, it may be possible to scrape out the gangrenous and offensive medullary tissue, and disinfect the cavity with pure carbolic acid ; or if it is due to a wound in the soft parts, it may be feasible to dissect out the implicated vein and surrounding tissues, or at any rate to remove the disintegrating clot after placing a ligature upon the vessel between the thrombus and the heart. A typical illustration of such treatment is that adopted for septic thrombosis of the lateral sinus complicating disease of the middle ear, where, after tying the internal jugular in the neck, the sinus is exposed by the trephine, opened, and all the septic clot removed, partly from above, partly from below. Ad- mirable results have been thereby obtained. The abscesses must be dealt with, where practicable, by opening them early and washing them out ; such wounds often heal well, and joints which have been distended with pus may recover with free mobility. Occa- sionally, however, although rigid asepsis has been maintained, the suppuration continues, and even sloughing of the abscess wall may follow. If the general condition can be improved, a barrier of granulation tissue will form in time, and repair be established. Constitutional Treatment consists in supporting the patient's strength by nourishing diet and stimulants, and in taking precau- INFECTIVE DISEASES io? tions to avoid bedsores or any local injury. Salicylate of quinine may be administered, though its value is doubtful. The antistrep- tococcic serum may also be utilized, and it may do good in cases which have not progressed too far. Tetanus. Tetanus is a local infective disease, due to the Bacillus tetani, and the characteristic symptoms are of a toxaemic nature. Predisposing Causes. — 1. Climatic Influences. — It is most com- monly seen in the tropics, where it may be almost epidemic, probably owing to the heat favouring the development and virulence of the organisms in the soil ; hot seasons assist its activity, and particularly when hot days are followed by cold nights. 2. Personal Proclivity. — It was formerly considered that negroes, horses, and stable attendants were specially liable to this disease, owing to some peculiar idiosyncrasy ; but with the recent addi- tions to our knowledge as to the habitat of the Bacillus tetani, it is extremely doubtful whether such an idea can be maintained. The organism is a facultative saprophyte — i.e., is capable of con- tinuing its development apart from the body — and is almost constantly found in garden soil, dust, or dirt of any kind. Those, therefore, who are likely to be much brought in contact with the ground, e.g., negroes, horses, and agricultural labourers, are liable to develop the disease, owing to their more constant exposure to infection. 3. Bad Hygiene is a most important predisposing condition. Every hygienic error favours its appearance, but especially the overcrowding of sick and wounded people into a limited space, and especially if full antisepsis is impossible. Exciting Causes. — 1. The existence of a wound. It may follow a lesion which causes no breach of surface, such as a blow with the fist, or a bruise, but in the great majority of cases there is a definite solution of continuity of the skin. Any region of the body may be thus affected, and it is rare for tetanus to occur in any but septic wounds ; where asepsis has been fully maintained the development of tetanus is almost unknown. Punctured or lacerated wounds of the sole of the foot, perhaps due to a dirty or rusty nail, are as likely to be associated with tetanus as any. 2. Infection with the Bacillus tetani. The first clue to the infective nature of this disease was obtained from the observation that, if portions of soil or garden mould were placed under the skin of animals, they died in a short time with tetanic symptoms, and in the pus and walls of the resulting abscess characteristic bacilli were observed. Experimenting in the same way, it has been found that the bacilli or their spores are very widely dis- seminated, and, indeed, are present in almost every sample of [o8 A MANUAL OF SURGERY garden or field soil ; they have been found in the grime on a working man's hand, and on dirty surgical instruments. Great difficulty was experienced in isolating and getting pure cultures of the bacillus, but at last Nicolaier and Kitasato succeeded, by heating the pus from an infected wound to a temperature of 80° C. for an hour, thereby destroying all the pyogenic and septic microbes. It develops in the body as long, delicate threads consist- ing of and breaking up into separate bacilli ; in artificial cultures spores form, but only at one end, causing such an appearance that the microbe is known as the 'drumstick' bacillus (Fig. 12). These organisms are anaerobic, i.e., flourish apart from oxygen, and, indeed, are best cultivated on nutrient gelatine at blood-heat in an atmosphere of hydrogen. They are not endowed with high vitality, and hence do not invade living tissues unless these have been previously bruised or damaged by the presence of septic inflammation. They grow in the neighbourhood and near the surface of septic wounds, the septic organisms absorbing all the oxygen present, and so originating the anaerobic conditions ta *4f* C\ Fig. 12. — Bacilli of Tetanus from Artificial Culture, showing the Spores located at the Ends of the Rods ('Drumstick' Bacilli). (TlLLMANNS.) necessary for their development. The mode of action of the bacillus consists in a local infection with general toxaemia ; that is to say, by its local development in a wound certain substances are produced which, when absorbed, act on the spinal marrow and brain, producing toxic effects very similar to those of strychnine. The actual tetano-toxin appears to have the nature of a ferment, its virulence being readily destroyed by exposure to a somewhat low temperature, e.g., one of 68° C., for about five minutes. It is not influenced by drying, and its activity is such that it is stated to be nearly 400 times as poisonous as strychnine. As to the post-mortem Anatomical Changes, but little need- be said, since they are not specially characteristic. The muscles are often pale, or show evidences of rupture and extravasation of blood. The peripheral nerves extending from the wound are red and congested for some distance, but this is probably only due to septic inflammation. The nerve centres frequently present INFECTIVE DISEASES ion areas of softening, and perivascular cellular exudation, with some hyperaemia. A few observations are on record in which the bacilli have been noticed on the pia mater and arachnoid of the human spinal cord, and others claim to have transmitted the disease experimentally by inoculation of the subdural space with an emulsion of the spinal cord or medulla. If these facts be true, they indicate that we have still much to learn as to the nature of the disease. Clinical History. — Acute Tetanus usually manifests itself in this country two or three weeks after infection (but sometimes abroad as early as a few hours or days) by a difficulty in opening the mouth, associated with a cramp-like pain in the muscles of mastication and of the neck. This soon becomes so marked that it may be difficult even to insert a paper-knife between the teeth {trismus, or lock-jaw), causing great difficulty in the administration of food ; to it is added a fixed and rigid condition of the muscles of the back of the neck and of the face, the latter producing a curious grin-like appearance (risus sardonicus), whilst dysphagia soon follows from spasm of the pharyngeal muscles. A considerable degree of fever is often manifested, but in some cases an apyrexial course is maintained until nearly the end. The spasms soon extend to the trunk and extremities, accompanied by cramp-like pains, and when fully established they may be excessively painful and violent, and the remissions between them but partial. Fortunately the disease usually involves the respiratory muscles late in the attack. The spasms can be excited by any form of stimulus, such as the slamming of a door, a draught of cold air, or some voluntary movement, and are always of a tonic {i.e., continuous) character. The body is contorted in various directions, and respiration much impeded by the fixation of the thorax. Occasionally the body is arched backwards {opisthotonos) by the contraction of the muscles of the back, the recti abdominis being firm and tense — ' as hard as boards ' ; sometimes it is doubled forwards {emprosthotonos), and in rare cases laterally {pleurosthotonos). The muscles may contract so violently as to be ruptured, whilst teeth have been broken and the tongue has ' been almost bitten off. The in- tellectual faculties usually remain clear to the end, which is generally due to exhaustion from a repetition of the convulsions, or more rarely to asphyxia induced by a prolonged fixation of the respiratory muscles. Before death the temperature sometimes runs up to 108 , or even, in one case, to 112 F., and it often continues to rise for a degree or two after death ; such hyper- pyrexia is mainly due to the continuous muscular contractions. The surface of the body is bathed in sweat, and the urine occasion- ally albuminous. Death may occur in twenty-four hours from the onset of the disease, or not for four or five days. Chronic Tetanus usually begins later after infection, is less severe in its symptoms, and more likely to be recovered from. A MANUAL OF SURGERY The course is usually afebrile, and the spasmodic contractions may be limited to the wounded part of the body whence the infection has arisen, or may be general. A special variety of this is known as cephalo -tetanus, or T. paralyticus (German, kopf -tetanus). It follows injuries within the area of distribution of the cranial nerves, and especially those about the supra-orbital margin, and is characterized by the association of trismus with facial paralysis, although spasms, both tonic and clonic, occur in other parts of the body. Spasm of the muscles of deglutition and attacks of maniacal frenzy are sometimes present, and hence the name T. hydrophobicus which has been applied to it. The paralysis is supposed to be due to an ascending neuritis of the facial nerve, which becomes compressed in the aqueductus Fallopii. The condition is uncommon, and the prognosis not quite so grave as in the acute cases. The Diagnosis of tetanus is rarely difficult. In the early stages it must be distinguished from simple trismus arising from dental irritation, or from inflammatory ankylosis of the temporo-maxillary joint. This may be readily accomplished by noting that there is also present in tetanus rigidity of the neck muscles. In the later stages strychnine poisoning leads to a very similar group of symptoms, but is recognised from it by the contractions being more sudden and violent, the relaxation of the muscles between the spasms complete, so that the mouth can readily be opened, whilst the hands are involved in the contractions, a rare sign in tetanus, and the muscles of mastication often escape. No difficulty should be experienced in distinguishing tetanus from hydrophobia, owing to the very different nature of the con- vulsions in the latter case — i.e., clonic and not tonic ; moreover, they affect the muscles of respiration and deglutition, whilst the history of the case, the early hallucinations, and the absence of tonic muscular contractions, are also characteristic features. The Prognosis is unfavourable in any case, but the so-called idiopathic variety is less fatal than the traumatic. The longer the case lasts, and the lower the temperature, the more likely is the patient to recover, whilst an acute onset, hyperpyrexia, sleep- lessness, delirium, and strabismus are bad signs. The length of the incubation period is also a most important factor, since it has been shown tha.t if it is under ten days, only 4 per cent, recover ; whilst if it lasts for eleven to fifteen days, 27 per cent, of cures may be expected, and if the outbreak is delayed for fifteen to twenty days, 45 per cent, of the patients live. Treatment. — Careful antisepsis applied to wounds is the surest means of preventing its occurrence, and the worse the sanitary conditions in which patients are found, and the more ragged the wound, the stricter should be the measures employed. If the originating sore is accessible, it should be freely excised and the wound cauterized, or the limb may be amputated ; but INFECTIVE DISEASES even then the tetanic convulsions may remain for a time, or even prove fatal, from the amount of poison already in the system. In addition to these local measures, the specific tetanus anti- toxin (prepared by drying the blood serum of an immunized animal) should be injected. At present the results of this treatment have proved disappointing, since few cases of acute tetanus have been saved by it, and the effect even in the more chronic cases is not at all certain. The explanation of this lies probably in the fact that the serum is in reality an immunizing agent (i.e., one which prevents the development of the organisms), and is not capable of dealing with the toxic bodies already acting on the nerve centres ; so that if a certain dose of the tetano-toxin has once been absorbed, it will produce its normal effects, even though the antitoxin prevents any further development of the organisms. The treatment should always commence with a large dose, and smaller amounts should then be administered once or twice a day, varying with the severity of the symptoms. If the fluid antitoxic serum is used, 20 to 30 c.c. may be given as the initial injection, followed by doses of 10 to 15 c.c. twice a day. This is introduced into the subcutaneous tissues of the abdomen and back, or in somewhat smaller doses into the veins, and causes but little inconvenience. If Tizzoni's dried antitoxic serum is employed, 2 to 4 grammes, dissolved in distilled water, may be given to start with, and 1 to 2 grammes for subsequent doses. During the last few years it has been shown by Roux and Borrel that the toxins are so closely attached to the nerve-cells that it is almost hopeless to expect even an intravenous injection of antitoxin to do much good, and hence it has been proposed to introduce it into the substance of the brain, enabling it thus to reach and act on the nerve centres more rapidly. The object to be gained is to immunize the medullary centres and prevent any further development of the toxin in the body ; what is there already must be allowed to work itself off. The injection is made through the dura mater into the posterior portion of the second frontal convolution on each side ; 2*5 c.c. of the dried serum dissolved in 5 c.c. of sterilized water are injected very slowly, and this may be repeated several times, if an interval of a few days be allowed to elapse between each injection. The point selected is placed midway between the external angular process of the frontal bone and the centre point of the line between the root of the nose and the external occipital protuberance. A small trephine may be applied here, or simply a hole drilled through the skull sufficient to allow of the introduction of a syringe, which is pushed about two inches deep into the brain. Of course, the strictest asepsis is essential. Probably it will be found wise to restrict this plan to the treatment of the worst cases, and it must be augmented by subcutaneous injections and the other subsidiary measures to be now noted, A MANUAL OF SURGERY The patient should be kept absolutely quiet in a darkened room, and free from all sources of irritation. Food should be nutritious, fluid, and unstimulating ; it has been suggested to feed the patient twice a day by a stomach-pump under chloroform. When the trismus is very marked, he may be fed through a soft rubber catheter passed into the pharynx through the^nose, unless there is a sufficient gap between the teeth to admit of its entrance. Opium, chloral hydrate, bromide of potash, physostigma, and curare, have been vaunted as beneficial drugs, but probably cases which have recovered after their exhibition would have done so without. Chloroform should be administered to control the spasms. Hydrophobia. Hydrophobia is an acute general infective disease, transmitted from animals to men, especially from rabid dogs, wolves, etc. It consists in an affection of the central nervous system, and one of its most marked features is the long and variable incubation period. It never originates idiopathically either in animals or man, and although the actual virus has not yet been isolated, there can be no doubt that it is a micro-organism. Infection usually follows a bite ; but if the teeth pass first through a garment, the virus may be wiped off, and the individual may escape. It has also been proved that if an infected animal merely licks an abraded surface the disease may be transmitted, even when the animal has not at the time shown any of the more typical signs of rabies. In the Dog, rabies manifests itself three to five weeks after infection, but the period varies considerably ; the original wound usually heals perfectly, or there may be some inflammatory thickening about it. Two chief varieties have been described — the raging or maniacal, and the quiet or dumb. Rabies with frenzy commences with a stage of depression, which is manifested by snappishness and irritability, especially towards other animals, by restlessness, and by the dog moping in dark corners, with a depraved appetite, eating any kind of rubbish or dirt, and even its own excreta. This period lasts for two or three days, and is perhaps the most dangerous, since there is nothing very suggestive about the symptoms. It is followed by a period of frenzy and maniacal fury, and this in turn is succeeded by a stage of paralysis, going on to death. During the whole attack the mouth is filled with ropy saliva, which the animal vainly tries to scratch away ; the bark loses its ring and becomes hoarse, and as the disease progresses the lower jaw becomes paralyzed ; finally, after partial or general convulsions, the animal dies five or six days from the onset. In the melancholic or dumb form the animal succumbs more rapidly, passing through the same stages as the above, with the exception of the maniacal period. The disease lasts then but two or three days. In Man the incubation period is most variable, lasting from days to months or years, but as a rule it does not exceed six weeks. During this interval the wound heals, although the scar may remain tender and neuralgic. The disease is ushered in by a vague sense of terror, with illusions of the senses and dis- turbance of the mind, lasting for about twenty-four hours. Restlessness, sleeplessness, loss of appetite, and a repugnance to fluids follow, with perhaps some slight febrile disturbance. The more characteristic symptoms are inaugurated by a convulsive stiffness of the tongue, neck, and especially of the muscles of deglutition and respiration, which becomes more marked if any attempt is made to swallow. These convulsions are clonic in character, and thus differ from those of tetanus; they become more and more generalized, being brought on after a time by almost any afferent impulse, however slight — such as a blast of cold air, a flash of light, a sudden noise, especially such as is caused by the movements of fluids ; swallowing is quite impracticable. The Infective diseases 113 mouth is usually filled with ropy mucus, which is very difficult to remove. The respirations became catchy, and a hiccoughing noise may be produced by the spasm of the diaphragm, which is sometimes thought to resemble the barking of a dog. Finally, the convulsions may entirely cease, and the patient dies, retaining his consciousness to the end, the fatal issue being due to the destructive changes taking place in the medulla, or to exhaustion ; it may, however, occur earlier, from spasm of the glottis. The disease lasts about a week, but may be more rapid, killing even in two days. The Post-mortem Changes are mainly negative. Evidences of acute inflam- mation of the lower part of the medulla, including the centres for the gth, 10th, and nth nerves, are observed on microscopic examination, the vessels being thrombosed, and the connective tissue infiltrated with leucocytes. The nerve fibres and ganglion cells may also be found degenerated. The salivary glands are always somewhat enlarged. Preventive Measures should be adopted immediately in all cases of bites from dogs which are either rabid or may possibly become so. The circulation in the limb should be arrested by a string or bandage, bleeding encouraged, and some powerful caustic, e.g., pure carbolic acid, applied as soon as possible. A free excision of the part is, however, preferable. Pasteur's Preventive Treatment. — A few years back M. Pasteur discovered the fact that the injection of an attenuated virus in increasing doses, and in gradually increasing strength, protects an animal or individual from the disease, and mirabile dictu ! will even catch up the poison already inoculated, and save the patient from its subsequent development, if too long a start has not been given. The method employed is as follows : A virus of constant and maximum intensity is first obtained by passing the poison from a dog through a series of rabbits, until the disease appears with regularity on the seventh day, all parts of the cord being then equally virulent. The material inoculated is obtained by mashing up a portion of the spinal cord or medulla of the diseased dog in sterilized broth, and injecting it with a hypodermic syringe beneath the arachnoid after trephining. All that is now needed is to take a series of these virulent cords, and dry them by hanging in a glass bell- jar with some caustic potash at the bottom for variable periods, the virus being thus weakened in its intensity, until at the end of fourteen days it is completely destroyed. Individuals are inoculated with portions of such cords, pounded up in sterilized broth, beginning with the weakest, and gradually increasing the strength of the injection, until a preparation of a cord which has merely hung one day is used. This method of treatment was introduced in 1885, and the results hitherto obtained have been such as to indicate that we have here a most potent preventive agent against hydrophobia, granted that the disease has not been allowed too long a start. When the disease has attacked an individual, only palliative treatment can be adopted. Every source of irritation and disturbance must be removed, and the patient kept absolutely quiet. With a view to diminish the spasms, chloral may be administered internally, or chloroform inhaled, or cocaine sprayed on the fauces. All the nourishment that the patient can possibly take should be administered, with the addition of stimulants. Anthrax. This disease results from infection with the Bacillus anthracis, which produces in sheep and cattle the so-called 'splenic fever.' In man, if the microbe is inoculated through the skin, it produces a form of carbuncle known as a ' malignant pustule,' although occasionally a more diffuse condition termed ' anthrax oedema ' arises from local infection ; whilst if the virus is absorbed by the lungs or intestinal canal, it originates a general inflammatory disorder, known as ' woolsorters' disease,' or anthracsemia The Bacillus anthracis (Fig. 13) is one of the largest of the pathogenic H4 A MANUAL OF SURGERY organisms, measuring 5 t0 20 /< in length, and 1 to 150^ in breadth. It is found in the blood of diseased animals in the form of rods or threads, composed of a variable number of individual elements (from two to ten). It is aerobic, immobile, grows best at about blood-heat, and liquefies gelatine. Well-marked spores are formed within the bacillus when cultivated artificially and in the presence of oxygen ; but spore formation has not been observed in the living tissues. The bacilli are readily killed by boiling for a few seconds, whilst the decomposition of the carcase in which they are present causes their death in about a week. The spores, however, are very resistant ; for whilst a 1 per cent, solution of carbolic acid kills the bacilli in two minutes, the spores remain alive after a week's immersion. Moreover, alcohol and even a 5 per cent, solution of carbolic acid have no effect on them. If a mouse is inoculated, say, at the root of the tail with a needle the point of which has been dipped in the blood of an animal which died of splenic fever, it succumbs in less than twenty-four hours, and bacilli are found in nearly every organ of the body Some animals are immune against the attacks of anthrax, especially the dog and rat ; and one of Pasteur's most useful discoveries was that of artificially providing immunity for cattle and sheep by inoculating them with an at- FlG 13. — Bacillus Anthracis, from Splenic Pulp of Infected Animal, x 1,200. (Crookshank's ' Textbook of Bacteriology.') Fig. 14. — l;acillus Anthracis in the Substance of the Kidney, to show how the Tissues become Infiltrated by it. x 600. (Crookshank's ' Text- book of Bacteriology.'} tenuated virus, obtained by exposing a cultivation for some time to a high temperature. Symptoms. — Infection with this organism usually occurs an;ongst graziers who tend the living animal, or butchers who deal with the carcase ; it is also met with amongst workers in hides or wool. Malignant Pustule commences as an angry red pimple at the site of inocula- tion, which rapidly spreads, with much infiltration of the base, whilst the centre becomes covered with vesicles, the serum within which contains the typical bacilli. _ This stage is associated with no pain, but only with great itching and irritation. As the pustule extends, the central part becomes grey, and finally black, constituting an eschar or slough, whilst around it upon an area of deep brawny congestion and oedema is a narrow ring of vesicles. The process gradually becomes more marked locally, whilst the lymphatic glands and vessels are also enlarged and involved in the disease. Generally, there is a certain amount of fever and malaise, which does not become pronounced until about the fourth or fifth day. The temperature then rises to 102 or 103 F., the pulse becomes rapid and irregular, and gastric irritability, vomit- ing, flatulence, more marked. Should the disease progress unchecked, the INFECTIVE DISEASES n 5 respirations become shallow and embarrassed, whilst signs of grave con- stitutional mischief, such as delirium or coma, manifest themselves, and the unfortunate individual rapidly succumbs, generally in less than a week from the onset, but sometimes in thirty to forty hours. More commonly the case runs a more favourable course, limiting itself to the local manifestations, which gradually clear up, the slough separating and the oedema disappearing. Of course, should there be more than one focus of mischief, the prognosis is much worse. Anthrax oedema runs a rapidly fatal course ; it is usually seen about the face and eyelids, the skin becoming red and brawny, as in erysipelas, and after a time covered with vesicles, whilst finally gangrenous patches appear. The lymphatic trunks and glands are also involved. Woolsorters' Disease (or anthracaemia) is the term applied to the general condition resulting from the development of these bacilli in the body without any external lesion. The virus gains access to the system either by swallowing or inhaling the dried spores. If they enter the respiratory tract, the patient complains of fever and malaise for a few days, followed by the development of a sero-fibrinous pleuro-pneumonia, the exudation containing large numbers of bacilli. This runs a rapid course, with high fever, great dyspnoea, impairment of the circulation, and finally collapse in the great majority of the cases. If the bacilli enter the stomach, they are usually destroyed by the acid chyme ; but should any of them or their spores reach the intestine, the alkaline contents form a suitable breeding-ground, and the walls of the gut are soon attacked and the disease becomes general. Colic, ciamps, vomiting, and blood-stained diarrhoea are the most marked features in such a case. The intestinal type appears to be not quite so virulent and fatal as the pulmonary, but is decidedly worse than the cutaneous. Treatment. — In the cutaneous affection, excision of the necrotic patch, and of all the infiltrated tissues around, and the application of the actual cautery or of pure carbolic acid, are usually recommended, though some who have had experience of the affection think such treatment of little value. Large doses of quinine may be given, but for the general disease merely symptomatic treatment can be adopted. De-emetised ipecacuanha has been much recom- mended, both as a local application after excision, and also internally in wool- /. sorters' disease. Gonorrhoea. Gonorrhoea is an infective process due to the action of a specific micro-organism, the Gonococcus (Plate I., Fig. 6), and charac- terized by a discharge of pus from the urethra. The organism was first isolated by Neisser in 1879, and is found with or without other pyogenic cocci in the discharge, most commonly in the epithelial cells or pus corpuscles, but sometimes apart from them. They are readily demonstrated by staining a film of pus, dried on a cover-slip, with methylene blue or gentian violet, and are almost always found in the diplococcus condition, i.e., they occur in pairs, held together possibly by some slight capsule; but often a con- siderable number, even up to twenty, are massed in a clump. The gonococcus is not easily cultivated, except in acid media ; the addition of an alkali checks the growth and renders the organisms less virulent. The disease has been transmitted both to animals and to the human subject by inoculation experiments with a pure and active culture. The organisms find their way into the male urethra, and invade the epithelial cells of the mucous membrane, within which they may often be seen ; they determine 8—2 n6 A MANUAL OF SURGERY an acute catarrhal inflammation, which quickly runs on to sup- puration. One great characteristic of gonorrhoea consists in the readiness with which it extends from one part to another, and the ease with which even a healthy urethral or vulval mucous mem- brane becomes affected by it, simple contact sufficing to determine an attack. Hence, although the symptoms are often very slight and insignificant, severe complications may arise, which may per- manently cripple the individual, or even destroy life, especially if other pyogenic organisms are present. The Symptoms of Acute Gonorrhoea usually commence within a few days of the infection, varying from two to eight. Most commonly the discharge appears about the third or fourth day, being preceded by itching of the meatus and a scalding pain on passing urine. The lips of the meatus are congested and swollen, and the discharge, which is at first thin and mucoid, soon becomes thick, abundant, and yellow in colour. This stage lasts for a variable time, and is sometimes associated with a good deal of dragging pain in the back and loins, together with some constitu- tional disturbance and fever. The bowels are usually constipated, and the appetite impaired. Occasionally the swelling and conges- tion of the mucous membrane are so great as to lead to retention of urine or haemorrhage from the urethra. The first attack is always more serious than subsequent ones, although it is more amenable to proper treatment. Gouty and rheumatic people are especially difficult to treat, and often suffer from relapses after the discharge has apparently ceased, and it is said that fair people suffer more than those who are dark. If suitable treatment is adopted, the discharge entirely ceases at the end of two or three weeks ; but if neglected, or sometimes in spite of treatment, the inflammation spreads backwards, giving rise to what is sometimes termed a Posterior Urethritis, since it involves that portion of the canal which lies behind the deep constrictor. It usually becomes evident about the end of the second week, and is characterized by frequent and painful mic- turition, a sense of pain and heaviness in the perineum, possibly a little blood in the urine, and a general feeling of depression. This extension backwards is always serious, since it is likely to precede complications involving the prostate, testis, or seminal vesicles, whilst it is an extremely common cause of Chronic Gonorrhoea or Gleet. A more or less abundant discharge continues for some time without any other troublesome symptom than occasional scalding on passing urine. The discharge varies in consistency, but is often thin and muco-purulent, whilst sometimes, if due to chronic prostatitis, it may be so clear and transparent that it resembles uncooked white of egg. The causes of gleet vary in different cases; it is sometimes due to an ulcerated or granular con- dition of the mucous membrane, the discharge then being yellow, whilst in others it arises from chronic prostatitis, a condition not INFECTIVE DISEASES 117 uncommonly associated with chronic enlargement of the vesiculae seminales. The latter condition may be recognised on rectal examination, whilst, when the prostrate is involved, flocculi of mucus in the shape of worm-like threads may be detected in the urine. A patch of granular urethritis should be suspected when one portion of the urethra is especially tender on the passage of a sound, but its presence can only be recognised with certainty by the use of the urethroscope. Every purulent discharge is not necessarily gonorrhceal, since a simple urethritis may follow connection with a woman who is simply suffering from leucorrhcea, or has scarcely recovered from her menstrual period, but with no suspicion of a venereal taint. In these cases infection may be due to ordinary pyogenic cocci, or possibly to the Bac. coli communis, which is known to be not an unfrequent cause of vulvo-vaginitis. A diagnosis of simple urethritis may be suggested by the history, but only a micro- scopical examination of the pus, and a demonstration of the absence of gonococci, can establish it with certainty. At the same time it must be remembered that gonococci are capable of remaining in a latent or passive state for a very long time in the folds or crypts of a mucous membrane, and hence it is quite possible for a person who has once suffered from it to be capable of transmitting the disease, although there may be no evidence of its existence at the time. In the Treatment of the early stages of acute gonorrhoea it is essential to keep the urine free from acidity by the use of alkalies, to maintain a free action of the bowels, and to allay the irritability of the parts by sedatives, such as tincture of henbane. The diet should be light and unstimulating, and all alcoholic drinks pro- hibited, as also strong tea and coffee, whilst the patient should be recommended to take plenty of bland fluids, such as barley water, or milk and soda-water. The scrotum should be supported in a suspender, and the patient advised against taking severe or pro- longed exercise. No local treatment is necessary, although the use of hot hip-baths may relieve the pain and irritation ; indeed, at this period injections are harmful. The same treatment must be adopted as long as the discharge is copious, and the scalding continues. As soon as these symptoms moderate, oleo-balsams in the shape of oil of sandal- wood (10 minims, in capsules, three to six times a day), copaiba (10 minims, in capsules or mixture, thrice daily), or cubebs (^ to 1 drachm doses, wrapped in wafer-paper), may be advantageously employed. Both cubebs and copaiba, especially the latter, are capable of producing a bright-red erythe- matous rash which causes much irritation, and may be extensively diffused over the body. The value of injections in the treatment of the disease has been much discussed, and is a point on which difference of opinion exists. Qn the whole, we are inclined fo think that many US A MANUAL OF SURGERY of the less severe cases of acute gonorrhoea can be successfully treated without them, and that they should never be employed when any local irritation or scalding is present ; but where the discharge tends to persist, or the urethra has been thickened by previous attacks, and especially in gleet, their use is imperative. To employ them with advantage, the following plan should be adopted : — The urethra is first washed out, so as to remove any discharge from it ; for this purpose the normal act of micturition answers admirably, so that the injection should be used immedi- ately after passing water. The rounded nozzle of a small glass syringe, containing about half an ounce, is inserted into the meatus, the lips of which are compressed over it. The fluid is thrown into the urethra, and held there for about twenty seconds by com- pressing the orifice with the finger and thumb, as the syringe is withdrawn ; then, on relaxing the pressure, the fluid escapes. Other forms of syringe, on the principle of the indiarubber bottle, etc., are recommended, but the glass is unquestionably the cleanest. Of the many different injections employed, perhaps the best consists of a mixture of tincture of catechu (10 minims to i ounce of water) and sulphate of zinc (2 grains to 1 ounce), or of permanganate of zinc (\ grain to 1 ounce), or nitrate of silver (\ grain to 1 ounce). The great secret consists in using the injec- tion four or five times a day at first, and afterwards night and morning, even after all visible signs of the discharge have ceased. The fluid should always be warmed prior to use, and care taken not to use too strong a solution. One is bound to admit, however, that many genito-urinary surgeons hold views very different to these, and, indeed, main- tain that gonorrhoea can be aborted, or, at any rate, rapidly brought under control at any stage by large injections of a weak solution of permanganate of potash, introduced with suffi- cient force to distend the urethra in all its parts and enter the bladder ; all the crypts and lacunae are thus reached by the anti- septic. The Treatment of Gleet is always a matter of difficulty. The general habits of the patient must be attended to, as in the acute stage, whilst the bowels must be opened, and absolute sexual continence enjoined to prevent the spread of the infection. Large doses of the liq. ferri perchlor., combined with a sufficient amount of Epsom salts to prevent constipation, may be given. Local treatment is generally necessary in the shape of injections as already described, and the passage of a cold solid metal bougie every three or four days has an excellent effect. Methodical dila- tation of the urethra is also advised, with the object of compressing all the crypts and lacunas, and removing pent-up secretion. If granular urethritis is present, the topical application of nitrate of silver may be undertaken through a urethroscope, but requires the greatest care, for fear of the subsequent formation of a stricture ; INFECTIVE DISEASES U g chronic prostatitis and vesiculitis are dealt with by counter-irrita- tion applied to the perineum, or possibly by sedatives, such as belladonna, administered in the form of suppositories. Complications of Gonorrhoea. — These may be conveniently arranged under the following headings : I. Complications due to Direct Extension. — In the male, the following may be described : Balanitis is of frequent occurrence in patients with long fore- skins. It is ordinarily due to pyogenic organisms, and not to gonococci. As a secondary result, inflammation of the lymphatics of the penis and inguinal bubo may follow. Lacunar Abscess arises from infection of one or more of the lacuna? with the gonococcus or accompanying pyogenic organisms. A tense painful swelling forms along the floor of the urethra, which may project into the passage and discharge either into the urethra, or externally, or both ; in the latter case a penile fistula will result. The abscess should be opened as early as possible from without, so as to prevent the latter occurrence, which is often very difficult to treat. If a fistula forms within a quarter of an inch or so of the meatus — a common situation — it seldom heals of itself, but may in some cases be closed by an application of the electric cautery or a weak solution of nitrate of silver. If, how- ever, it remains intractable, the fistula should be laid open into the meatus. When it occurs in the body of the penis, a plastic operation is usually required ; it consists in paring the edges and dissecting up the skin on either side so as to bring it together in the median line. Chordee results from inflammatory infiltration of the corpus spongiosum or one of the corpora cavernosa, so that when the penis becomes erect, it is bent downwards or to one side, owing to incomplete distension of the infiltrated tissue. This condition is exceedingly painful, and most marked at night when the patient becomes warm in bed. It is best dealt with by applying cold to the part, and by administering bromide of potassium or opium at bedtime. Inflammation of Cowper's Glands may in some cases give rise to deep suppuration in the perineum, with symptoms very similar to those of acute prostatitis. It is dealt with in the same way as the latter complaint. Acute and Chronic Prostatitis (Chapter XXXVII.). Acute and Chronic Vesiculitis (Chapter XXXIX.). Epididymitis arises by distension along the vas, and will be fully described at Chapter XXXIX. It rarely commences before the third week, and often not until the fifth or sixth, being perhaps caused by the injudicious use of injections, or by a blow or squeeze, especially if the scrotum is lax and pendulous. Acute Cystitis (Chapter XXXVII.). In the female many complications arise by direct extension of A MANUAL OF SURGERY the gonorrhoeal inflammation along the urinary and genital tracts. The primary affection is most commonly a vulvovaginitis, and this may spread to the lining membrane of the uterus, or even to that of the Fallopian tubes (salpingitis), whilst ovaritis and pelvic peritonitis also occur. II. Complications arising from Direct Transmission of the Virus. — Gonorrhoeal Proctitis sometimes results in the female from infec- tion by the discharge which escapes from the vulva, whilst in both sexes it may be due to unnatural practices. Considerable tenesmus is produced, accompanied by a thick muco-purulent discharge. It is treated by injecting lotions of acetate of lead and opium, or of boric acid. Gonorrhoeal Rhinitis has also been seen in a few cases. It leads to an abundant discharge of pus, and should be treated by warm, soothing injections, followed after a time by dilute astringents. Gonorrhoeal Conjunctivitis occurs either in adults, when it is unilateral to start with, or in infants when it is bilateral, and due to infection during transit through the maternal passages (ophthalmia neonatorum). It is a remarkable fact that, although gonorrhoea is so very prevalent, such a small proportion of the patients suffer from conjunctival infection ; it would appear, there- fore, that not only must there be direct contact with the gonorrhoeal poison, but in addition the mucous membrane must be in a recep- tive condition. In the adult variety it is ushered in by redness and irritability of the eye, followed quickly by a discharge which is at first mucous, but soon becomes purulent. The eyelids are red and swollen, the conjunctiva is thickened and spongy (chemosis), and the discharge liable to accumulate within the conjunctival sac. If allowed to progress unchecked, the cornea may be injured by the inflammatory process, ulceration, or even necrosis, ensuing, and possibly general panophthalmitis. The first detail in the Treatment consists in protecting the opposite eye by means of what is known as Buller's shield ; a watch-glass is fixed in a piece of mackintosh over the eye, and kept in position by plaster. The affected conjunctiva must be unremittingly attended to night and day, so as to prevent accumulation of discharge ; it is fre- quently irrigated with warm boric acid lotion, and every four hours the membrane is carefully washed, dried, and swabbed over with a solution of nitrate of silver (5 grains to 1 ounce). Between the applications lint wrung out of iced boric acid lotion is kept over the eye. This plan of treatment is continued until the sup- puration ceases, and then the silver salt is omitted, and simple astringents, such as chloride or sulphate of zinc, substituted. In infants the disease often runs a rapid and severe course, and is very likely to lead to ulceration or sloughing of the cornea, a complication not uncommonly followed by escape of the lens and blindness. Crede's preventive treatment should always be adopted for new-born children, viz., washing out the conjunctival INFECTIVE DISEASES sac with a weak solution of nitrate of silver or corrosive subli- mate soon after birth. When suppuration occurs, the treat- ment to be adopted is practically identical with that detailed above, except that it is useless to attempt to limit the trouble to one eye. III. Complications resulting from General Absorption. — Gonor- rhoea!. Sclerotitis, or inflammation of the deep subconjunctival fibrous tissue, is a rare affection, arising quite independently of the disease just described. It is characterized by marked sub- conjunctival redness, the globe of the eye becoming distinctly tender. Local applications of atropine are required, and, if need be, leeches to the temples. Gonorrheal Affections of Joints are not uncommon sequelae, arising usually in the subacute stage of the disease. They occur either in the form of a synovitis with effusion, or as an arthritis, which may or may not suppurate, but usually ends in ankylosis. The former is probably due to the embolic transmission of gono- cocci alone, whilst in the latter pyogenic organisms are also con- veyed to the articulation. For symptoms and treatment, see Chapter XX. Any muscular, tendinous, ligamentous, or aponeurotic tissues may become inflamed and painful during the course of an attack of gonorrhoea. Special mention must be made of the involvement of the ligaments supporting the arch of the foot, since, if the cause is not recognised and the patient is still allowed to walk, the arch of the foot may be lost, and a permanent flat foot result. Secondary abscesses, similar to those of pyaemia, are sometimes developed in cases of gonorrhoea, probably resulting from the diffusion of pyogenic organisms, and even general infection of a septicaemic nature has been described, leading to a fatal issue. YVe now come to a group of diseases which have been classified by Virchow under the term Infective Granulomata. They are all characterized by the formation of growths more or less resembling granulation tissue, which either persist or undergo various de- generative changes. They are all infective in nature, and most of them chronic in their progress, although acute manifestations are occasionally met with. Five conditions are included under this heading, viz. : Syphilis, Tuberculosis, Glanders, Leprosy, and Actinomycosis. Syphilis. Syphilis is an infective disease, resulting from inoculation with some specific virus, which has not yet been identified with certainty. Ltistgarten demonstrated an organism in the initial lesion which was supposed to be the bacillus of syphilis, but it A MANUAL OF SURGERY was probably nothing more than the bacillus always present in smegma. The inability to transmit the disease to animals is one of the great difficulties in the way of a complete bacteriological examination. Syphilis is characterized by the appearance of a primary sore, usually known as a hard chancre, which is followed in the course of a few weeks by evidences of general infection, referred mainly to the skin and mucous membranes, comprising the secondary stage. After a variable time, known as the intermediate period, during which symptoms may be absent, tertiary manifestations may show themselves in any and every part of the body. Mode of Infection. — Acquired syphilis is almost always due to infection of the genital organs arising from impure connection. Occasionally cases are met with in which the disease is transmitted by other means (syphilis insontium), and then the primary lesion is often located on some other part of the body (extragenital chancres) ; thus, a hard chancre may be found on the lips, as a result of drinking out of the same glass or smoking the same pipe as a syphilitic patient, or may even be acquired by kissing. The disease is not always equally infectious ; in the primary stage the discharge derived from the chancre will alone convey the con- tagion ; in the secondary period the virus is found in the blood of the individual, and hence all pathological exudations, as also the blood itself, may transmit the disease. Pure secretions, e.g., milk or urine, are free from infection, although if mixed with a serous exudation from abraded surfaces, as so frequently occurs in the case of the saliva, they at once become infective. The semen is probably an exception to the above rule, since, although the maternal passages may entirely escape, the ovum becomes diseased. It is usually held that in the tertiary stage the patient is no longer capable of transmitting the affection. The syphilitic virus is exceedingly resistant to the action of antiseptics, and hence the risk of infection is very great, even though prompt measures are taken to destroy it. Thus, many cases are on record in which an abraded surface was brought into contact with a syphilitic poison, and, although cauterized with fuming nitric acid within a few hours, the disease ran its ordinary course. In one case, however, under our observation, in which a student's finger was accidentally pricked with a bent broad needle, which a moment before had been inserted into the anterior chamber of a syphilitic patient suffering from a secondary sup- purative iritis, nitric acid was applied within a quarter of an hour, and although a suspicious indurated spot formed six weeks later at the site of injury, no other evidences of syphilis have been observed, in spite of the fact that the individual had not previously suffered from the disease, and took no mercury. One attack of syphilis usually confers immunity on the patient from further outbreaks of the disease, even if exposed to infection. INFECTIVE DISEASES This protection is, however, not always permanent, since well- authenticated cases have been observed of second attacks of syphilis, in which the primary lesion was followed by distinct signs of general infection. Course of the Case. — The stage of Incubation lasts for a variable period, extending from two to six weeks ; as a rule, however, evidences of induration of the sore can be detected about the third week. It is probable that long ere this the virus has entered the circulation, and hence removal or destruction of the local lesion has not the slightest influence upon the progress of the case, unless it can be undertaken immediately after infection. During this period nothing unusual is noted at the site of inocula- tion, if the infection is purely syphilitic, and the local sore merely a slight abrasion ; it may even heal completely in the course of a few days, and nothing further is noticed until the typical in- duration manifests itself. Not unfrequently, however, pyogenic infection occurs or a soft chancre is also present ; in the latter case the lesion does not heal in a typical manner, and the base of the ulcerated surface becomes indurated after a time. I. The Primary Stage of syphilis is characterized by the develop- ment of a typical primary sore, associated with enlargement of the neighbouring lymphatic glands. It is usually situated on the base of the prepuce, close to the corona glandis, or on the fraenum ; in the female the inner aspects of the labia majorae or nymphae are the most common sites. The primary sore does not invariably present the same appearance, although it is always characterized by a certain amount of infiltration and induration. Should the superficial abrasion have healed, a localized growth of almost cartilaginous hardness forms in the cicatrix, closely adherent to and invading the cutis ; but if a soft sore has first developed, the surface remains ulcerated more or less deeply, though the base becomes indurated. The following are the chief forms in which the chancre manifests itself, (a) The desquamating papule is a slightly elevated spot, which is extremely irritable, of a dusky colour, and free from ulceration. It is usually small, but hard, and its surface covered with epithelial scales. If exposed to friction, or to the irritation of retained discharges, ulceration is very likely to take place, and an ordinary Hunterian chancre will then form. Unless this occurs, it may run its course unobserved, and thus a patient becomes syphilitic without being able to trace the time or source of infection, (b) The indurated, hard, or Hunterian chancre is that most commonly seen ; it results from the irritation of a papule, or is developed in association with a soft sore. It consists of a distinctly localized infiltration and induration of the sub- mucous or subcutaneous tissues, giving rise to a lump which feels like a pellet of cartilage ; or the induration may be more exten- sively diffused through the surrounding structures. In some 124 A MANUAL OF SURGERY cases there may be but little elevation of the growth, and the sur- face is free from ulceration, constituting the variety known as the ' parchment induration ' of Ricord, and not unfrequently seen on the glans penis. Where, however, the prepuce or body of the penis is involved, greater induration takes place, owing to the laxity of the connective tissue. When affecting the base of the prepuce, the induration tends to spread transversely, producing a collar- like mass, which on retraction of the part rolls back en bloc in a very characteristic manner. Examined microscopically, the new formation consists merely of a mass of round and spindle cells packed closely together, with a certain amount of intercellular fibrous tissue ; giant cells are sometimes seen. The blood-supply of the part is scanty, a fact which explains the readiness with which ulceration occurs. Several chancres may be seen on the same individual if the infection occurs at one time, and it is possible that a patient could be infected at two different periods if only a short interval elapsed between the inoculations ; but the disease is not generally auto-inoculable, and when once a hard chancre has developed on the under surface of the prepuce, the glans does not become infected from contact. Multiple chancres are always of small size, and the induration is less marked than usual. A Urethral Chancre is usually situated just within the lips of the meatus, constituting a sore with an indurated base. It may be felt as a hard nodule on grasping the urethra between the fingers, and gives rise to a thin serous discharge, often blood- stained. The orifice itself is sometimes the site of a chancre, and the induration may completely encircle it. This condition is very apt to be followed by a stricture. Extragenital Chancres are often observed, perhaps most com- monly on the lips, finger, and nipple ; but, of course, any part of the body may become affected. They are usually characterized by a greater amount of infiltration and less distinct and definite induration than in the forms met with on the genital organs ; hence the swelling is more prominent and vascular, and if ulcera- tion occurs there is a greater amount of discharge, which forms a thick scab over the surface. The neighbouring lymphatic glands are enlarged, and sometimes surrounded by infiltrated tissue. This condition has often been mistaken for epithelioma, from which, however, it can be distinguished by the age of the patient, the character of the sore, its rapid development, and the simul- taneous enlargement of the glands. The course of the case is generally more severe than when the primary lesion is in the usual situation, a fact possibly explained by the disease remaining unrecognised till secondary symptoms appear. In surgeons or accoucheurs infection may occur on the fingers, usually starting by the side of the nail. It gives rise to an indolent sore, which becomes infiltrated and ulcerates, tending to INFECTIVE DISEASES spread under the matrix and along the semilunar fold. There is a good deal of discharge and pain, and the terminal phalanx becomes swollen and bulbous. The epicondyloid and axillary glands are enlarged as the case progresses, and the condition has more than once been mistaken for malignant disease. Phagedena is a form of spreading ulceration, rarely met with at the present time, except in connection with venereal disease, and, according to most authorities, seldom apart from syphilis. It always attacks unhealthy and debilitated individuals, especially men with phimosis. The discharge, which is abundant and sometimes offensive, is retained under the long foreskin, and this, together with the end of the organ, becomes red, swollen, and infiltrated. On dividing or retracting the foreskin, the affected surface is found to be sloughy, and the ulceration, unless checked by treatment, rapidly spreads, and may destroy glans and prepuce, and even attack the body of the penis. A similar condition is occasionally seen in connection with an inguinal bubo, and then the integrity of the femoral vessels is threatened. The Treatment consists in the relief of all tension by division of the foreskin if that structure has not been already destroyed, followed by prolonged im- mersion of the patient in a hot hip-bath, in order that the toxins may be so diluted as to prevent any extension of the ulceration, and thus facilitate the natural processes of repair. If the patient cannot be kept for twelve or twenty- four hours in a warm bath, it will suffice to immerse him in warm water for two or three hours every day. In the intervals the wound should be dressed with iodoform, and covered with lint dipped in lotio nigra. Under such circumstances, the surface of the sore quickly cleans, and becomes covered with healthy granulations. The later treatment is conducted as for primary syphilis, although the depressed condition of the general health may necessitate the administration of tonics and even a visit to the seaside. Should treatment by immersion in hot water be for any reason impracticable, the old-fashioned plan must be resorted to, viz., scraping the sore, and freely cauterizing the base with pure carbolic or fuming nitric acid. Possibly, where there is much slough, this may advantageously precede immersion in a bath. The Lymphatic Glands which receive lymph from the region in which the sore is situated become characteristically enlarged. They move freely under the skin and feel hard, like bullets, pellets of cartilage, or almonds (hence the term ' amygdaloid ' which has often been applied to them) ; they are usually quite painless, and there is no tendency for them to suppurate if the infection is purely syphilitic ; but if the original sore is septic, or also inoculated with the virus of a soft chancre, an abscess often follows, one or more of the inguinal glands breaking down, and causing a painful, red, and brawny infiltration of the superjacent integument. After a time the skin gives way, and is often found extensively undermined. Occasionally the lymphatic vessels extending from the sore to the glands become the seat of a chronic lymphangitis, and may be felt as hard cords beneath the skin. The dorsal lymphatic of the penis is frequently blocked in this way, and gives rise to solid or lymphatic oedema of the prepuce and glans. Should the chancre suppurate, an abscess may form in the course of the lymphatics. The Diagnosis of a syphilitic from a soft sore is not always easy. 12b A MANUAL OF SURGERY Of course, where there is no ulceration, .and the typical induration of the base can be felt, no doubt need arise. But when the primary sore is septic, and an excavated ulcer is present, sur- rounded by infiltrated and hyperaemic tissues, it is difficult to be certain as to the nature of the case. The inguinal glands are enlarged in both varieties, and the fact that suppuration occurs proves nothing. Even the existence of a ' satellite ' chancre from auto-inoculation only demonstrates the presence of a soft chancre; it does not prove the absence of syphilis. (See also on ' Soft Chancre,' Chapter XXXVIII. ). In such cases it is often neces- sary to wait for the development of secondary symptoms before a decided opinion can be given. The Duration of the primary sore varies in different cases, and depends in great measure on whether treatment is commenced early or late. If the case comes under observation during the first six weeks, and a mercurial course is at once started, the chancre heals, and the induration usually disappears in from six to eight weeks. The glands in the groin, however, remain enlarged for some time. The longer the case is left untreated, the more slowly does the hardness disappear. If no mercury is administered at all, the induration may last for twelve months or more, and then slowly passes off, although it may run a much shorter course. From an uncomplicated syphilitic sore but little scar results, although a well-marked cicatrix may follow a soft or septic chancre. Re-induration of the cicatrix sometimes occurs from too early a cessation of the mercurial course, or from some localized irrita- tion, or from a fresh exposure to infection. It is occasionally due to a tertiary or gummatous development, and will then be free from lymphatic complications. II. Secondary Syphilis. — In the secondary stage, the virus is diffused generally throughout the body by means of the blood, which is itself infective. A certain amount of constitutional disturbance may exist, the patient feeling ' seedy ' and out of sorts, whilst in some cases distinct febrile phenomena and head- ache have been noted. Well-marked anaemia is often present, and on examination the red corpuscles are found to be deficient in number, and defective in the amount of haemoglobin contained within them. The chief secondary manifestations consist in the appearance of various forms of rash on the skin and mucous membranes, associated with a general enlargement of the lym- phatic glands, sore throat, mucous tubercles and condylomata, loss of hair, and other less common phenomena, and these usually show themselves in from seven to nine weeks from the time of inoculation, although they may be delayed to a much later date. Their intensity also varies considerably, the phenomena being sometimes scarcely evident, and at others very marked. They are also influenced greatly by the period at which the administra- INFECTIVE DISEASES 127 tion of mercury commences ; the earlier the drug is given, the less obvious are the secondary phenomena. The Cutaneous Eruptions of secondary syphilis are chiefly characterized by the fact that, although any form of rash may be simulated, no specially distinctive variety is originated. More- over, in the same individual the eruption is not always of the same character throughout, several distinct types developing in separate parts of the body (polymorphism). The rash is usually more or less symmetrical, the colour in the early stages being a dusky red, resembling that of raw ham, whilst later on it becomes of a more coppery hue ; occasionally, however, it may be a bright rosy red. Syphilitic rashes do not completely fade on pressure, but leave a brown stain, and give rise to but little irritation or itching ; they always tend to progress from the simpler types, due to hyperaemia, to the more serious, in which infiltration and overgrowth are evident. In the simplest form, merely a hyperaemia is present, some- times appearing as a dusky mottling of the skin (roseolous syphilide), which quickly fades, or may persist whilst other types are developing. If distinct papillae become infiltrated and hyperaemic, a papular syphilide is said to be present ; such may become either vesicular or pustular, constituting the vesicular or pustular syphilides ; the latter change is uncommon, and only appears in bad cases or in debilitated patients. Another form of eruption is the squamous syphilide, characterized by patches of hyperaemia and infiltration, combined with superficial desquama- tion. It is usually bilateral, and, unlike simple psoriasis, affects the flexor rather than the extensor surfaces. In the later stages, distinct nodules or tubercles are produced in the skin, which may even run on to ulceration (tubercular syphilide). As to the situation of the rash, the roseola is usually limited to the abdomen, whilst the other forms are often widely scattered over the trunk and extremities, involving, however, the flexor more than the extensor surfaces of the limbs. A somewhat characteristic phenomenon is the appearance of a papular rash on the forehead, sometimes known as the corona Veneris. The Mucous Membranes may be affected in much the same way as the skin. The fauces become red and congested, the hyper- aemic area being abruptly limited, and semicircular in outline ; symmetrical ulceration usually follows, originating near the anterior pillars of the fauces, and spreading thence to the tonsils and along the soft palate to the uvula. These ulcers are shallow, have sharply-cut edges, and often present a characteristic greyish appearance, constituting what is known as a ' snail-track ' ulcer. The secondary sore throat rarely results in extensive loss of substance, and hence pharyngeal stenosis is not common at this period of the disease. Smoking undoubtedly aggravates these conditions. Concurrently with these manifestations in the fauces 128 A MANUAL OF SURGERY a number of bare patches from loss of epithelium may be seen on the dorsum of the tongue, or several small superficial, but very painful, ulcers may develop on the inside of the cheeks or lips. Mucous tubercles and condylomata are somewhat similar affec- tions, though more pronounced, arising in the secondary stage in connection with mucous membranes and those parts of the skin which are soft and moist. Mucous Tubercles consist of slightly- raised patches of enlarged and infiltrated papillae, white in appear- ance from the superficial epithelium becoming sodden, and often progressing to actual ulceration. Examined microscopically, the papillae are found to be definitely enlarged, and the epithelium heaped up over them. They are most commonly observed at the corners of the mouth, on the inner aspect of the cheeks, the side of the tongue (often due there to the irritation of rough teeth), or the margin of the anus ; in the last-named situation they are usually symmetrical, one side being infected from the other. They are also not at all uncommon between the toes, and the ulcers caused thereby become exceedingly offensive from septic con- tamination. Condylomata are similarly the result of overgrowth of the papillae, differing from mucous tubercles merely in the extent to which this has been carried. They consist of definite wart- like masses, which may attain a great size, constituting a cauli- flower-like growth. They are most commonly seen about the anus or vulva, in the former situation being often mistaken by the patient for piles ; they give rise to an abundant, highly infec- tive discharge. A similar condition is sometimes met with on the dorsum of the tongue, and is then known as ' Hutchinson's wart.' The Lymphatic Glands are usually enlarged throughout the body during this period of the disease, being felt as round, hard swellings beneath the skin. The extent of the glandular com- plication is possibly a measure of the degree of virulence of the affection. The condition of the nuchal and epicondyloid glands should always be ascertained in suspicious cases, since, if no obvious local cause exists for their enlargement, syphilis is very probably present. Syphilitic Alopecia. — The hair becomes dull and lustreless, and either comes out in patches from the scalp, eyebrows, beard, etc., or there is a general ' thinning.' The follicles, however, are not destroyed, and after a time the hair will grow again as before. Later secondary manifestations consist of flying pains in the bones (osteocopic), iritis, and various nervous lesions, whilst periosteal nodes may form on the tibiae and other bones, or a symmetrical chronic effusion develop within the synovial mem- brane of joints. Syphilitic Iritis is characterized by pain in the eye, generally referred to the supra-orbital nerve, together with some interference with vision, and possibly a little lachrymation and photophobia. INFECTIVE DISEASES 129 On examination a bright-red circular zone immediately surrounds the cornea, resulting from hyperaemia of the ciliary vessels. The iris is lustreless, and its definition somewhat blurred. Its colour is changed, a blue iris becoming greenish-yellow from the presence of lymph. The pupil is diminished in size, and perhaps irregular ; its movements are always considerably hampered, and sometimes entirely prevented by the formation of adhesions either to the back of the cornea (anterior synechiae) or to the lens capsule (posterior synechiae). Occasionally small yellowish nodules are seen on its surface, consisting of plastic lymph. The Duration of the secondary stage varies considerably in different cases, and is largely influenced by the character of the treatment and the period at which it is commenced. The sooner the patient is brought judiciously under the influence of mercury, the less severe the secondary phenomena, whilst cases in which treatment has been delayed are likely to be much more trouble- some. Hence the disease is often of an aggravated type when following extragenital chancres, as also in women, by whom the primary lesion often passes unnoticed and untreated. When treatment is commenced within- four or five weeks of infection, the secondary stage is slight, and all traces of its existence may pass off in two months or less ; if mercury is not administered until the cutaneous eruption has appeared, this stage is likely to last longer. The condition of the patient's health is an important factor, as also the previous habits, particularly as to temperance, since syphilis always follows a more aggravated course in the weakly and the dissipated. Even under the best circumstances, the patient is liable to outbreaks of the affection within the first twelve months. Relapses are by no means uncommon, being usually due to intermissions in the treatment. The rash which appears under these circumstances is often of a more charac- teristic type, the papules being grouped into rounded or corymbose figures. III. The Intermediate or late Secondary Stage comprises a group of symptoms which form a link between those already described and the tertiary phenomena; and indeed no distinct limits to this period can be defined, nor need it appear at all if the patient's general health is good, and the treatment has been carried out regularly. Some of the secondary manifestations, especially those of the bones and joints, may persist through this period, whilst even if they have disappeared, the patient is liable to suffer from ' reminders ' in the shape of various cutaneous affections, and perhaps epididymitis. Deep lesions of the eye (choroido-retinitis), and of the central nervous system (syphilitic monoplegia), are not uncommon, the latter usually arising from anaemia of the cerebral centres due to a syphilitic endarteritis (p. 254). The principal cutaneous affection is the so-called syphilitic psoriasis, most frequently seen on the palms and soles. 9 »3° A MANUAL OF SURGERY A squamous syphilide is often observed in the secondary stage, but is then symmetrical and readily influenced by mercury. In this intermediate period, the lesion may be bilateral or limited to one side, according to whether it appears early or late. In the former there is a considerable tendency to proliferation of the epithelium, together with deep cracks and fissures; in the latter there is less epithelial overgrowth, but the edges are often dis- tinctly serpiginous in outline, and there is an infiltrated border. Rupia and Ecthyma are both met with in this stage of the disease. They are characterized by an infiltration of the skin, which progresses to ulceration. In rupia the discharge forms a distinct scab on the surface, which increases in thickness by the Fig 15. -Rupia of Face. (From Wax Model in Museum of Royal College of Surgeons.) deposit of successive layers one under the other, each being somewhat larger than the one which precedes it ; hence a scab shaped like a limpet-shell is produced, resting on an inflamed and hyperaemic base (Fig. 15) ; any part of the body may be affected in this way. In ecthyma no scab forms over the ulcerated surface, or, if formed, it readily comes away, leaving exposed a hollow punched-out sore, surrounded by an area of vivid congestion. Under appropriate treatment these conditions disappear, but leave depressed, whitish cicatrices, often surrounded by pigmentation. A somewhat unusual intermediate manifestation is a subacute symmetrical epididymitis, in which the cord also becomes thickened, enlarged, and tender. INFECTIVE DISEASES 131 IV. Tertiary Syphilis. — -The phenomena occurring in this stage may appear within six months of infection, or not for twenty or thirty years. They are mainly characterized by infiltration and overgrowth of the connective tissues of the body. Such may occur in one or many places, and may be diffuse or localized. In the former case the organ or part affected becomes enlarged, hard, and sclerosed, and unless the condition is treated promptly, the normal tissue of the part may entirely disappear, being replaced by fibro-cicatricial tissue. If, however, the process is localized, a Gumma is formed. Any tissue in the body may be the seat of a gummatous deposit, which apparently arises without any definite cause, although occasionally its onset may be determined by an injury. The involved area becomes occupied by a round-celled infiltra- tion, the cells being derived partly from proliferation of the connective tissue, and partly from leucocytes. This gradually increases in amount, the normal tissue of the part disappear- ing before it. Very few vessels penetrate into the mass thus formed, which otherwise somewhat resembles granulation tissue. As the process extends peripherally, the older portion is trans- formed into cicatricial tissue, and, finally, owing mainly to the compression of the vessels by its contraction, and partly to a concurrent syphilitic affection of the tunica intima of the nutrient arteries (p. 254), the blood-supply of the centre of the gumma fails, and the tissue dies. In this stage a gumma consists of a central, whitish-yellow slough, devoid of vessels, formed by the oldest portions of the growth in a condition of fatty degenera- tion and necrosis ; surrounding this is a zone of loose vascular fibro-cicatricial tissue, whilst the periphery of the tumour is con- stituted by a round-celled hyperaemic infiltration of the normal tissues of the part. Under appropriate treatment, the whole of this new formation may disappear, being replaced by a fibrous cicatrix ; but not unfrequently the central portion breaks down into a gummy, semi-purulent fluid, which finds its way to the surface and is discharged. Where the necrotic mass is large, a portion of it may remain adherent to the surrounding tissues after ulceration has taken place, looking somewhat like a piece of wet wash-leather. Under exceptional circumstances the central slough may become encysted by the formation of a fibrous capsule, and calcification of the centre may even occur ; this is stated to be most frequently found in the brain, testis, and liver. Clinically, the appearances vary according to whether the gumma is cutaneous or subcutaneous. Cutaneous gummata (Fig. 16) are very frequently observed in tertiary syphilis, especially in the earlier stages. They occur as dusky-red nodules of firm consistency, and but slightly painful. Many such growths are often grouped together in one region, and when ulceration has occurred, they produce by their confluence 9—2 '32 A MANUAL OF SURGERY sores with a rounded or serpiginous outline. Considerable destruction of tissue follows, but they are readily cured, giving rise to depressed white cicatrices, surrounded by pigmentation. Any part of the body may be involved, but a very common site is about or just below the knee, on the outer, rather than the inner, aspect of the leg. Occasionally a diffuse infiltration of the skin is met with in this stage, appearing as a red hyperaemic area with a rounded or serpiginous border, and not at all unlike lupus in appearance. It is readily amenable to treatment, and runs a much more rapid course than lupus ; the edge is usually thickened to the same extent all round, and there is but little tendency to the formation of outlying nodules. The apple-jelly-like granulations, so typical ^ *»Mt~ - JjKM 1 ■ ■ .i^r- " ijLi-c^. v, S(*f d^ ^^B w Fig. 16. — Cutaneous Gummata. of lupus, are of course not present. A cicatrix is usually pro- duced, even if ulceration has not taken place. A subcutaneous gumma develops as a firm nodule, which gradually increases in size, and sooner or later travels towards the surface ; the centre of the tumour becomes elastic and fluctuating ; a certain amount of pain and tenderness is noticed, and when the skin is affected, it becomes dusky and even oedematous. Ulceration follows, and the contents of the gumma thus escape. The sore produced is deep, the edges being sharply cut, and perhaps undermined ; the base of the ulcer consists of granu- lation tissue, although it is sometimes covered by the charac- teristic slough. The peculiar features of tertiary syphilis, as it affects special regions, will be described under the appropriate headings : vide syphilitic diseases of arteries, of lymphatic glands, of muscles, INFECTIVE DISEASES of bones, of joints, of the lips, of the pharynx, of the tongue, of the larynx, of the rectum, of the testis. The symptoms arising from gumma of the brain will be alluded to at Chapter XXIV but the general relation of syphilis to the nervous system has been purposely omitted, since it belongs rather to the physician than to the surgeon. The Prognosis of syphilis is good if the patient comes under treatment at a sufficiently early stage, and if he has no idiosyn- crasy which prevents the administration of mercury or iodide of potassium. In persons suffering from extragenital chancres, which are not recognised till late, the disease often runs a more than usually severe course. The general health of the patient, and perhaps a peculiar predisposition, may influence the evolution of the case considerably, whilst the co-existence of tuberculous disease may render the prognosis peculiarly unfavourable, especially when the disease is inherited. The character of the rash, and the extent of the general glandular enlargement in the secondary stage, may perhaps give some indication of the gravity of the case ; where the eruption is but slightly marked, the other symptoms are usually mild, whilst a pustular eruption is almost always of grave import. Death is rarely produced by any of the secondary manifestations, but may occur in the tertiary stage, when important viscera, such as the brain, spinal cord, liver, etc., are involved. As to the Curability of syphilis, the general opinion held at present is that, if the disease is seen early, and treated satis- factorily, the patient will in all probability never suffer from any further manifestations after the secondary symptoms have dis- appeared. A cure can, however, never be definitely promised, since, should the general health of the patient become impaired, characteristic syphilitic phenomena may make themselves evident even thirty or forty years after the primary lesion. There is also no doubt that certain cases are to be looked on as absolutely incurable, owing probably to the fact that they were not brought under treatment until tertiary phenomena were present ; such are usually seen amongst females. The Treatment of syphilis consists in the administration of mercury during the primary and secondary stages, and of iodide of potassium, with or without mercury, in the late secondary and tertiary periods. Many different methods have been suggested for the administra- tion of mercury, in order that the patient may derive the greatest amount of benefit from the drug with the minimum of incon- venience, (a) It is usually given by the mouth, either in the form of pills composed of grey powder (grs. i. — iii., t.d.s.), or of the green iodide (gr. ^ — i, t.d.s.), or as a mixture containing a solution of corrosive sublimate. The last method is distinctly objectionable, inasmuch as its prolonged use in sufficient doses disturbs the digestion. Grey powder is perhaps the best means i 3 4 A MANUAL OF SURGERY of giving the drug ; the patient should commence with 2 grains, given three times a day, or in some cases ij grains four times a day, combined with a little extract of opium or pulv. ipecac, co. if there is any tendency to diarrhoea ; but this addition is not always needed. This should be cautiously continued until all prominent signs of the disease have disappeared, and then the dose is gradually reduced, (b) Inunction of the mercurial ointment is also frequently adopted, and with great success, inasmuch as it is less likely to cause digestive derangements. If the ordinary officinal ointment is employed, a portion as large as a hazel-nut is rubbed into the groin or axilla nightly, the part being washed the following morning, and not used again for this purpose for three or four days ; if the ointment is made up with lanoline, a some- what smaller amount is required. Possibly this is one of the best ways of bringing a patient rapidly under the influence of the drug. (c) Mercurial vapour baths may be advantageously employed where the cutaneous eruption is very extensive. The patient sits naked on a cane-seated chair, and covered with a blanket or specially constructed cloak reaching from the neck to the ground, and not touching the body ; 20 or 30 grains of calomel are placed on a metal plate surrounded by a trough containing about 1 ounce of water. The water is boiled, and the calomel sublimed, by means of a spirit-lamp placed under the chair. In about twenty minutes all the calomel will be volatilized, and deposited in part upon the skin of the patient, who perspires freely during the process. He then gets into bed between warm blankets, without wiping the skin. This treatment may be combined with medication by the mouth, (d) Mercury is sometimes administered by subcutaneous injections, in the form of the perchloride, | grain or less being injected once or twice a week into the substance of the gluteus maximus. A little thickening of the site of injection results, but quickly passes away, and suppuration scarcely ever follows. During the course of mercury, the patient's general health and habits must be carefully regulated, all excesses in drink and diet being forbidden, and strict instructions given as to keeping the teeth and gums clean. To minimize the risk of throat and mouth trouble, it is wise to stop all smoking for at least six months. The dose required varies in different individuals, being increased in robust people, and diminished in those who are weak or un- healthy. It should always be pushed until mild physiological effects are produced in the shape of slight tenderness of the gums, but salivation of the patient is undesirable. Full doses are usually required for four or five months, followed by a milder course, which should extend till the end of the first year. Although symptoms of excessive mercurialism are generally induced by overdoses of the drug, yet in some people a very small dose suffices to produce severe effects ; the existence of this idiosyncrasy must not be forgotten, and large doses should INFECTIVE DISEASES J 35 never be administered without first ascertaining whether or not the patient can tolerate them. When mercury is producing toxic effects, the gums become soft and spongy, and bleed readily on pressure. Salivation follows, and even acute glossitis may be produced, whilst the breath is always exceedingly offensive. In worse cases the teeth become loose, and even necrosis of the alveoli has been known. Derangements of the digestion, in the shape of colicky pain and diarrhoea, are also observed. The treatment of this condition consists in suspending the administra- tion of the drug, and giving a sharp saline purge, whilst the spongy state of the gums is remedied by the use of an alum or chlorate of potash mouth-wash. Iodide of potassium is essential in the treatment of the tertiary and intermediate stages. It appears probable that its chief action is the removal of gummatous tissue, but that it has no other influence upon the course of the disease ; in order to prevent recurrence of the trouble, mercury is still required. The dose of iodide should not exceed 5 grains to start with, and is gradually increased until in some cases 1 drachm four times a day has been reached. A feeling of depression and sinking at the epigastrium is often produced, but may be alleviated by the addition to the mixture of sal volatile (11\_. xv.) or carbonate of ammonia, as suggested by Sir James Paget. Symptoms of coryza may follow, and an acneiform eruption over the shoulders and face, which, however, often disappears on increasing the dose. Sometimes a vesicular, or even bullous, rash is caused by this drug. When large doses are given, bicarbonate of soda or potash must be combined with it, in order to prevent its decomposition by the gastric juice, and plenty of water should always be taken im- mediately afterwards to assist in its dilution and facilitate its absorption. The iodides of sodium and ammonium are some- times substituted for the potassium salt, on the plea that they give rise to less depression. Other drugs, such as sarsaparilla and iron, are often combined with iodide of potassium in the later stages of the disease, and may be useful. The Local Treatment of syphilitic sores consists mainly in the application of various preparations of mercury. The primary chancre is usually treated with lotio nigra on lint, iodoform being sometimes employed if septic ulceration is present. Mucous tubercles in the neighbourhood of the anus or vulva, or between the toes, are best dealt with by keeping them scrupulously clean and dusting them over with powdered calomel, or by the applica- tion of calomel ointment, a piece of lint being inserted between opposing surfaces to keep them from rubbing one against the other. Secondary ulceration of the throat does not usually require local treatment, as it soon disappears under the influence of mercury. A mercurial gargle may, however, be employed, or in l 3 G A MANUAL OF SURGERY bad cases calomel may be placed on a hot copper coin, and its vapour inhaled. Superficial gummatous ulcers are treated by re- moving the scabs, and applying some form of mercurial oint- ment. A determined attempt should be made to keep deep gum- matous ulcers in an aseptic condition, since the advent of sepsis to such sores, especially if they are connected with bones, makes a marked difference in their progress. In neglected cases the wound may become exceedingly foul, and in chronic cases a hectic temperature and even amyloid degeneration of the viscera have been observed. When gummata come to the surface and point, they should be opened with the same precautions as are adopted in the case of an abscess, and either dressed antisepti- cally, or their cavity stuffed with lint or gauze soaked in lotio nigra. Inherited or Congenital Syphilis. Syphilis may be conveyed to the ovum either by direct trans- mission from the father or mother alone, or both parents may be tainted with the disease. Occasionally the mother acquires syphilis during pregnancy, and in such cases the foetus also becomes affected. In those instances where the ovum is infected from the father, whilst the mother has escaped, the latter becomes in measure protected, so that, if the child is put to her breast, she does not contract the disease, even though there are ulcerating lesions on the child's gum and lips ; healthy wet-nurses are invariably infected {Colics' s Law). Whether the immunity is permanent or not is still a matter of uncertainty, and even the inviolability of this law has recently been called in question. The length of time during which the patients retain the power of transmitting the disease to the foetus is an exceedingly difficult point to determine, and one which is constantly coming before the practitioner, who is asked to decide at what period it is safe for a syphilitic patient to marry. The rule of practice generally followed is that no one suffering from syphilis should be allowed to marry until he or she has been free from all symptoms for at least twelve months, and even then it is advisable that a mild course of mercury should be given for about three months shortly before marriage. A syphilitic foetus often fails to arrive at maturity, the mother miscarrying at the end of six or seven months. This is probably due to a specific affection of the endometrium, especially involv- ing that portion of the decidua which enters into the formation of the placenta. The circulation and nutrition of the foetus are thereby impaired, so that it is usually born not only dead, but in many cases macerated, and partially decomposing. This may be repeated for several pregnancies, and then a living child is produced. In many cases, however, a living child is born at INFECTIVE DISEASES '37 full time at the end of the first pregnancy, in spite of the syphilitic infection of the parents. At birth the child often appears healthy and well nourished, but is sometimes small and imperfectly developed. The first definite symptoms of the disease manifest themselves at a variable period, extending from three weeks to three months, after birth ; the child becomes thin and emaciated ; the skin, which hangs in wrinkles over the body, changes to a dull earthy colour, whilst the features looked pinched and wizened, like those of an old man. Marked anaemia is always present, and tends to persist for a con- siderable time. Speaking generally, the symptoms of inherited syphilis are similar to those of the acquired disease, except that Fig. 17. — Child with Inherited Syphilis, showing Radiating Scars round the Mouth. (From a Photograph kindly lent by Dr. G. F. Still.) the primary lesion is absent. Thus, during the first year of life the child develops various cutaneous eruptions, mucous tubercles, and superficial ulcerations of the mucous membranes. A dusky red roseola, especially about the nates (napkin area), may first be noticed, but does not last long. This is usually followed by the appearance of mucous tubercles at the angles of the mouth, in the nose, and around the anus, as also in the moist folds of the groin, and between the scrotum and thigh. The sores on the lips are sometimes very marked, giving rise to ulcerated surfaces, which, by their subsequent cicatrization, leave radiating scars (or rhagades), especially about the angles of the mouth (Fig. 17). Other cutaneous affections, such as squamous syphilides of the 138 A MANUAL OF SURGERY soles of the feet, together with papular syphilides of the body, and a bullous eruption becoming pustular (pemphigus), are also observed, the last mentioned, however, only occurring in de- bilitated infants. A catarrhal rhinitis is a very early and constant manifestation, giving rise to obstructed nasal respiration, or snuffles. This affection is often protracted, going on to ulceration and destruction of the nasal bones and cartilages ; their subsequent development is thus prevented or impaired, and hence the bridge of the nose remains depressed and sunken, even when adult life is Fig. 18. — Head and Face of a Patient with Inherited Syphilis, showing Depressed Bridge of Nose and Frontal Bosses. (From a Photo- graph.) reached (Fig. 18). Enlargement of the spleen and liver is also common. Many infants during the first year of life die from malnutrition or marasmus ; but if properly treated a considerable proportion regain their health within six or eight months, all the manifesta- tions described above disappearing, although their scars may remain. The child's subsequent development is frequently im- paired, and it often retains an almost pathognomonic facies. After the first year, any of the tertiary phenomena which appear in acquired syphilis may develop, but, in addition to these, peculiar manifestations may be produced, especially affecting the teeth, bones, and cornea. INFECTIVE DISEASES »39 The Teeth in inherited syphilis are sometimes very char- acteristic. The temporary teeth usually appear early, are discoloured, and crumble away. The permanent teeth are often sound and healthy, but are sometimes deformed. The central incisors of the upper jaw are those most particularly affected, but the upper laterals and the incisors of the lower jaw may also be involved. Instead of being broader at the crown than at the root, they diminish in size from root to crown, being stunted, and separated from one another by interspaces. The angles of the crown are rounded off, and a distinct notch, forming a large segment of a small circle, occupies the centre. The enamel is often imperfectly developed, and hence they decay early. Occa- sionally they may be shaped like a screw-driver, narrowing from root to crown, and with a straight free border. The notched and stunted teeth described above are sometimes known as 1 Hutchinson's teeth,' but they are not very commonly seen at the present day. The Bone affections observed in inherited syphilis will be de- scribed at Chapter XVIII. Interstitial Keratitis, or diffuse inflammation of the cornea, usually occurs about the age of puberty, or earlier. It is limited at first to one eye, but the other is almost certain to be similarly affected at a later date. It commences as a diffuse haziness of the cornea, which looks something like ground glass, associated with hyperaemia of the ciliary region. Red areas, or ' salmon patches,' may be produced in the midst of the opacity, due to a new formation of minute vessels. There is no tendency to ulcera- tion, but in protracted cases the anterior part of the eye may bulge forwards, constituting a condition known as ' anterior staphyloma.' The inflammation may spread to the iris and ciliary body. With suitable precautions the cases usually do well, although treatment for several years may be necessary. The Treatment of inherited syphilis should commence as soon as definite manifestations of the disease are present. The general health must be attended to, and if the mother is unable to nurse the child, it must be brought up by hand ; on no account must it be given to a wet-nurse. Mercury is best administered by anointing the under surface of the flannel belly-band with mer- curial ointment, or the same preparation may be rubbed into the soles of the feet every night. This should be continued until all secondary phenomena have disappeared, and advisably until the child is a year old. Cod-liver oil may also be ordered with advantage in some cases. When tertiary symptoms appear, iodide of potassium and mercury may be given in a mixture, in suitable doses. The local treatment of external lesions is conducted according to the rules laid down for the acquired type of the disease. i 4 o A MANUAL OF SURGERY Tuberculosis. By tuberculosis is meant a condition resulting from the develop- ment within the tissues of the body of certain definite anatomical structures, known as tubercles, and caused by the growth and activity of the Bacillus tuberculosis. Before the fact was established that such lesions were due to a micro-organism, they were usually termed strumous or scrofulous, and even at the present day these two names are occasionally employed to indicate that condition of constitutional weakness which predisposes to the appearance of tuberculous disease. It is better, however, to avoid the use of such misleading terms. .^Etiology. — i. The individual is often predisposed to the develop- ment of this disease by some inherited weakness, as indicated by the fact that parents, relations, or ancestors have suffered from some similar affection, or that it has occurred in other branches of the same family. It is becoming doubtful, however, whether heredity plays such an important part as was formerly attributed to it, and whether the disease is not much more commonly due to direct infection. Considerable ingenuity has been exercised in describing various types of physiognomy supposed to be charac- teristic of a tuberculous inheritance, and although not always present, these appearances are not unfrequently observed. Two chief varieties are described, viz., the sanguine and the phlegmatic. In the former, the individual is slight and well proportioned, possessing a thin, delicate skin, often freckled, and so transparent that the subcutaneous veins are readily seen. The hair is fine and auburn-coloured, or even reddish, the conjunctivae are thin and pearly, the eyelashes well developed, and the fingers long and tapering. Such children are usually excitable and precocious in their habits, and possess taking manners. The phlegmatic type is characterized by a short, stunted stature, with somewhat coarse features, and strong though somewhat short limbs. The skin is coarse and muddy-looking, the lips thick, the hair rough and brown. In children of either type there is a considerable tendency to the development of eczema, inflammation of the mucous mem- branes, and a subacute enlargement of the lymphatic glands, all of which are simple in nature, but may constitute a suitable nidus for the development of tubercle, especially if the child is run down by some preceding illness, such as measles or scarlet fever. They also suffer frequently from cracked lips, and as a result of the irritation caused thereby considerable infiltration and thickening may follow. Although tuberculous disease is most frequently seen in young people or children, no age is exempt from its attacks, even elderly persons being affected by what is known as ' senile tuberculosis.' These senile manifestations differ in no way from those met with in the young. INFECTIVE DISEASES 141 2. Unhealthy surroundings and bad hygiene certainly predispose to its development ; hence it is seen, perhaps, in its severest forms amongst the poor, although it is only too common amongst the rich, arising usually from improper feeding and want of fresh air in the case of children, and not unfrequently from faulty hygiene or carelessness, especially as to judicious clothing, in adults. 3. A local nidus suitable for the development of the micro- organism usually exists, although tuberculous infection occasion- ally follows wounds and punctures in previously healthy parts. Thus, as already mentioned, lymphatic glands in a condition of chronic enlargement and hyperemia form a suitable breeding- ground for the bacillus, as also bones and joints which are in a state of congestion as a result of slight and often overlooked injuries. 4. The ultimate exciting cause of tuberculosis is the develop- Fig. 19. -Bacillus Tuberculosis in and around Giant Cell. shank's 'Textbook of Bacteriology.') (Crook- ment within the tissues of the Bacillus tuberculosis (Fig. 19). This organism, which was originally isolated by Koch, is always present, though not always recognisable, in the products of the disease. It exists in the form of fine straight rods, the individual bacilli being 2 [x to 5 \i in length, and "i /x to 3 //. in breadth. They are always cultivated artificially with difficulty, growing best on glycerine agar-agar, and only slowly on coagulated blood serum at the temperature of the body. The colonies produced consist of yellowish -white or greyish scales, more or less cheesy in appearance. The organism gains admission to the system either through some abrasion of the skin, or by the digestive tract with some article of food, especially milk, or by inhalation, its presence in the dust of rooms occupied by phthisical individuals having been frequently demonstrated, and being due to the dessication of the sputum. The infective nature of the disease has been abundantly i 4 2 A MANUAL OF SURGERY demonstrated by clinical and experimental work during the last few years. Thus, it can be readily transmitted by inoculation to animals, especially to rabbits and guinea-pigs, the anterior chamber of the eye of the rabbit being a very favourite spot, owing to the fact that the growth of the characteristic neoplasm can be readily watched, and that spontaneous tuberculosis never occurs in this region. Transmission of the disease to the human subject has frequently occurred from direct inoculation through a puncture or abrasion of the skin, as in the case of surgeons whose fingers have been wounded whilst operating on tuberculous cases. The risk of living with phthisical patients, or of occupying their rooms without previous thorough disinfection, is also fully admitted at the present day. Pathological Anatomy. — The tuberculous process consists in the development of the so-called grey or miliary tubercles, which run together, and produce larger masses, and these undergo secondary changes, whilst the tissues invaded become inflamed and gradually disappear, being replaced by pulpy granulation tissue, in the midst of which the tuberculous foci can be seen. Miliary tubercles can be recognised by the naked eye as greyish, semi-translucent nodules, rarely exceeding a millet-seed in size. The process which leads to their formation almost always com- mences in or around the small vessels, and can perhaps be best studied in the pia mater. The bacilli are presumably brought to some area of lowered vitality, settling in the tunica intima. This leads to an overgrowth of the endothelial elements — i.e., to an endarteritis, which may spread for some distance — and this in turn is followed by a proliferation and infiltration of the surround- ing connective tissues, resulting in the obliteration of the affected vessel, and the formation of the characteristic tuberculous nodule. In the earlier stages all that is seen is an ill-defined mass of con- nective-tissue cells, distinctly nucleated, and aggregated around a bloodvessel, thus giving rise to no very characteristic appearances. The structure of a fully-developed tubercle (Plate III., Fig. i) is as follows : In the centre lies a giant cell, containing a large number of nuclei, which are often arranged around its periphery, or grouped together at one or other pole. Delicate processes extend from the giant cell, and form a fine network, in the meshes of which are situated the cells of the surrounding zone. These are rather larger than ordinary leucocytes, with a granular protoplasm and a clearly-defined oval nucleus. They are known as epithelioid cells, although they are derived from the neighbouring connective tissues, and are, in fact, identical with fibroblasts. Around them are collected a large number of smaller cells, probably leucocytes, and these merge into the surrounding structures, which are gradually changed into granulation or fibro-cicatricial tissue. • In many cases the giant cell is absent, and, indeed, it must in no way be looked upon as a characteristic feature of tubercle, since such *l T3 tuC >, tio-S -p o £•- 5 »2 g «♦"« ° r* O s g >, CO is 51 d ""* 1 a OJ oj^ to a num esse; hilst ocyt »_] o > o »-i , ® "* W - T3 <^ ^? < 5 c £ SJ 3 § the g arou into on tl to INFECTIVE DISEASES 143 cells are often met with in syphilis and other conditions where active tissue changes are taking place. Its origin is a little doubtful, but it is probably derived from an enlargement of one connective-tissue corpuscle, or by the union of several such cells. No vessels are present in the tuberculous neoplasm, and as a result degenerative changes are certain to follow. Not unfrequently a number of these tubercles develop close together, and under these circumstances the intervening structures disappear, being re- placed by granulation tissue, which may in part become further transformed into cicatricial tissue. By the use of appropriate staining reagents it can be demonstrated that bacilli are present in the giant cell, and sometimes in the zone of epithelioid cells surrounding it (Fig. 19), but as soon as degenerative changes commence, the organisms can no longer be recognised. If the disease progresses, caseation always ensues, owing partly to the defective nutrition of the neoplasm, partly to the specific action of the bacillus or its products. Not only does the centre of the miliary tubercle undergo this change, but also the granulation tissue around or between the separate nodules. A caseating focus of yellow or crude tubercle, as it used to be termed, consists of a degenerating centre surrounded by a zone of granulation or fibro-cicatricial tissue, in which are scattered miliary tubercles, and which in turn gradually runs into normal tissue (Plate III., Fig. 2). The ultimate result of this process depends to a large extent on the general health of the individual and the treatment which is adopted. 1. If the parts are kept at rest, and free from external irrita- tion, and if the constitutional weakness is combated by suitable measures, the destructive process may come to an end. In such a case the peripheral layer of granulations is converted into dense fibro-cicatricial tissue, which forms a sort of capsule, and checks the advance of the disease. The caseous material is either removed by an invasion of leucocytes, or becomes calcified, usually leaving a firm fibrous nodule, perhaps interspersed with calcareous particles. Possibly some of the tuberculous material persists in a latent state in this mass, like an ' extinct volcano,' ready to be lighted up into activity if the opportunity is given. In less advanced cases the diseased tissue may be so completely removed as to leave scarcely any trace of its existence behind. 2. The caseous material is often transformed into a yellowish fluid, usually known as pus, by a process of emulsification, due to the absorption of fluid from the hyperaemic tissues around, and resulting either from mechanical causes, or more probably from the activity of the tuberculous organisms, or possibly from infec- tion with ordinary pyogenic or septic bacteria. In such cases a chronic or subacute tuberculous abscess results, the structure and characters of which have been already described (p. 50). i 44 A MANUAL OF SURGERY One of the chief features of tuberculous disease is its great tendency to diffusion. This may occur (a) locally, by direct con- tinuity of tissue, or by extension along neighbouring lymphatics or bloodvessels ; or (b) distant viscera or organs may become infected, probably through dissemination by the bloodvessels. Thus phthisis is a not uncommon sequence of a similar affection of bones, joints, or lymphatic glands, whilst meningeal tuberculosis is more frequently associated with tuberculous affections of the genital organs, (c) Moreover, any tuberculous lesion may lead to acute general tuberculosis, in which the disease is scattered widely throughout the body, giving rise to rapid emaciation, high fever of an intermittent type, and usually severe diarrhoea, dyspnoea, and delirium or coma, death ensuing in a few weeks. Treatment. — It must be fully recognised that tuberculosis is an infectious, and therefore, to a large extent, a preventable disease, and it is the duty of all medical practitioners to do everything in their power to limit its ravages. We cannot here enter into this subject, but would merely mention the dangers to the general public arising from the distribution of milk obtained from tuber- culous cows, and from the indiscriminate expectoration of tuber- culous sputum. Curative treatment is based on the assumption that natural processes of repair have a considerable influence upon the course of the disease. When Koch first discovered the bacillus, a great impetus was given to surgical treatment, and some authorities went so far as to maintain that it was as necessary to extirpate every particle of diseased tissue as in a case of cancer. The pendulum has now slowly swung back, and we are more and more endeavouring to promote healthy repair of the lesions by constitutional measures. The value of an abundance of fresh air is fully admitted, and many sanatoria for the open-air treatment of phthisis and other tuberculous lesions are being built or planned. In this country residence by the seaside, especially in such bracing places as Margate, or, if that be too cold, Ramsgate, Bournemouth, or Ventnor, is usually recommended. At the same time, plenty of good food, such as milk and eggs, must be taken. Local foci should be kept at rest, and, if the disease is external, elevation and steady pressure (as by Scott's dressing) are desirable acces- sories. On the other hand, if a tuberculous lesion is sufficiently localized and suitably situated, as when it occurs in the lymphatic glands of the neck, total excision is the ideal treatment, although one has sometimes to be satisfied with scraping. In this process the possibility of disseminating the disease by too vigorous manipulations must not be overlooked. Any open tuberculous sores should be well scraped, and the surface then swabbed over with liquefied carbolic acid, and dressed with gauze soaked in an iodoform emulsion. INFECTIVE DISEASES 145 The manifestations of tubercle as it affects special organs are dealt with elsewhere under the appropriate headings (see diseases of skin, bones, joints, lymphatic glands, kidney, testis, etc.). Glanders. Glanders is primarily a disease of the horse, ass, or mule, which is trans- mitted to men by direct inoculation, and hence is usually seen only in stable attendants and those brought in contact with such animals. It is charac- terized by the development of inflammatory swellings under the mucous membrane of the respiratory tract, which break down and ulcerate, and by the formation of similar growths, embolic in origin, in the lungs and other viscera, which go on to abscess formation. There is now no doubt that the disease is due to a definite micro-organism, the Bacillus mallei, which was isolated about 1882 by Schutz and Loffler, and has since been cultivated outside the body ; the experimental evidence as to its being the cause of the malady is quite complete. In Horses and other animals, glanders manifests itself by a formation of larger or smaller rounded swellings in the mucous membrane of the nose, which break down and ulcerate, giving rise to a thin, sero-purulent discharge, and perhaps destruction of the bones and cartilages. The lymphatic glands, especially those under the jaw, early become enlarged, constituting the ' farcy buds' of farriers, and by their ulceration may leave ragged, foul sores. The lymphatic trunks to and from the glands are involved (' corded veins '), whilst the lungs and internal viscera may also be infected, and undergo destructive changes, usually ending in suppuration. The disease is often chronic, lasting perhaps for years ; any undue strain put upon the animal may lead to an acute outbreak, which is fatal in six to twelve days. In Man, glanders generally starts about the hands and face, but occasionally in the nasal mucous membrane. In acute cases the incubation period lasts from three to five days, and is succeeded by the occurrence of malaise and febrile disturbance, followed by severe pains in the bones and joints. The site of inoculation becomes swollen and angry, whilst the lymphatics leading from this to the nearest glands are enlarged and inflamed. An eruption of papules, which somewhat resemble those of small-pox, occurs around the primary lesion, on the face, and in other parts of the body ; but each papule, as also the primary lesion, breaks down and goes on to the formation of an ecthy- matous-looking ulcer. It is not an uncommon feature of these sores, when placed over a bony surface, to involve the periosteum and lay bare the sub- jacent bone. Similar changes occur in the viscera, muscles, and joints, and these being associated with high fever of an asthenic type, may suggest the existence of pyaemia. In such cases death may ensue in seven to ten days. In Chronic Glanders simikr symptoms are met with, but the course is slower ; there is little or no fever ; the disease is less extensive, and inter- missions are not uncommon. Total recovery is stated to occur in 50 per cent, of the cases. It may affect the nasal mucosa, leading to chronic ulceration, but more commonly it appears in the shape of chronic abscesses, which often extend deeply, even down to the bones and are very difficult to deal with. In one case the disease gradually spread down along the peronei muscles, and in spite of repeated scrapings and the application of pure carbolic acid, the process was only arrested at the point where the peroneus longus disappears into the foot. It is important to determine the Diagnosis as early as possible, in order to undertake energetic local treatment. The local lesions are distinguished from small-pox by the presence of the characteristic bacilli in the discharge, by the fact that they more extensively involve the subcutaneous tissues, and by the absence of umbilication. Chronic cases resemble syphilis and tuberculosis, but the history of exposure to infection from animals suffering from the disease is most important, as also the result of cultivations made from the discharge. 10 146 A MANUAL OF SURGERY When the bacilli are grown on potatoes, a colony of a yellowish, honey-like character forms in two or three days, which gradually turns to a chocolate- brown colour. Inoculation of the peritoneal cavity of a guinea-pig with some of the secretion leads to acute orchitis in two or three days, the testicles being enlarged and the skin over them reddened ; the affection usually runs on to suppuration. Mallein, a sterilized culture of the organisms, may also be used for diagnostic purposes, an injection of a minute dose causing a sharp febrile reaction if glanders is present. Treatment in acute cases can be of use only when undertaken early, and before general infection has ensued. The local foci should be thoroughly extirpated, either by the knife, or by scraping and applying some active cauterizing agent. The same treatment must be adopted in chronic cases, and may then need frequent repetition. Leprosy. Leprosy (syn. : lepra, or elephantiasis Gracomm) is a general infective disease due to the Bacillus lepra;, characterized by the formation of granulation-like neoplasms, which arise primarily in connection with the skin and nerves. The bacilli of leprosy closely resemble those of tubercle, being 4 to 6 /( long and 1 n broad (Fig. 20). They are stained by most of the ordinary methods of demonstrating bacteria, and are found in abund- ance in the tissues ; but the disease has not yet been transmitted to animals. Leprosy, though formerly common in this country, is now but rarely seen, and has then been imported. In Iceland, Norway, Russia, and the East it is still frequently met with, although the compulsory separation of lepers enforced in Norway is much diminishing the number in that country. It is apparently con- tagious, though with ordinary care infection may be avoided ; but in the exhalations and secretions bacilli are abundant, at any rate in the later stages. Opinions differ as to whether or not it is transmitted by heredity, but probably this is not the case. Symptoms. — Two cnief varieties of leprosy exist, viz., the tuberculated and the anaesthetic, or non-tuberculated ; but the two are often associated. Tuberculated or Cutaneous Leprosy is the form most commonly seen in Europe. Nothing may be noticed for months or years after exposure to the contagion, and then, after a period of malaise, associated with dyspepsia, diarrhoea, and drowsiness, a distinct febrile attack is noted, lasting for days or weeks ; it may be ushered in by a rigor, and the temperature is usually of a remittent type. This is followed by, or associated with, the appearance of shiny, red, hyperaemic spots, which are from the first infiltrated, slightly raised, and hyperaesthetic ; they are usually situated on the forehead or cheeks, on the outer side of the thighs, or on the front of the forearms. They may fade away and disappear entirely, and then again become evident, or fresh patches may be developed, and always with febrile symptoms. After a variable period, ' tuberculation ' ensues; numbers of little pink nodules form over the site of one or more of the erythematous patches, and these gradually Fig. 20. — Leprosy Bacilli contained within Epithelial Cells. INFECTIVE DISEASES 147 increase in size and coalesce, until possibly they become as large as a walnut or hen's egg, and are then of a brownish-yellow colour. _ Almost any part of the surface of the body may be invaded in this manner, but the face is especially prone to be involved, and the resulting disfigurement is very marked, a curious leonine appearance being imparted to the features. The nodules are more or less anaesthetic from the pressure of the infiltration on the nerves, and the ultimate result of the process may vary considerably ; resolution sometimes occurs, or the nodules may be transformed into de- pressed and pigmented cicatrices, or ulceration may ensue. Visceral com- plications and enlargement of the lymphatic glands follow, any fresh deposit being associated with febrile phenomena. The testes atrophy, and sexual power is lost in both sexes. Death is usually due to septic phenomena, laryngeal obstruction, or disease of the lungs or kidneys ; but the patient may live for many years. The nodules consist of masses of granulation tissue, and scattered through them are numbers of large cells, containing multitudes of bacilli (Fig. 20). Considerable difficulty exists in cultivating these organisms, but Ducrey has succeeded by using an alkaline medium, and excluding air Fig. 21 — Leprous Hand. (From Wax Model in Museum of Royal College of Surgeons.) Anaesthetic, or Non-tuberculated, Leprosy is the most common form met with in hot climates. The earliest phenomena consist in a certain amount of malaise without appreciable fever, together with sharp tingling or lancinating pains and tenderness along the course of certain peripheral nerves. The ulnar, median, peroneal, and saphenous nerves are those most often affected. This is followed by muscular weakness, running on finally to paralysis, various modifications of sensation, and trophic phenomena, involving at first only the skin, but later on attacking bones, joints and muscles. Circular yellowish- white patches are observed in the skin, spreading peripherally, and tending to run together, forming large irregular ovals; the border is often raised, and hypersensitive, but the central portions become atrophic, dry, white, and anaesthetic. The anaesthesia gradually spreads, and serious lesions, partly due to trauma, partly arising from trophic changes, result. The muscles atrophy and contract, and give rise to deformity, the hands sometimes becoming markedly ' clawed,' as in ulnar paralysis (Fig. 21). Interstitial absorption of the bones of the peripheral portions of the limbs may lead the fingers, toes, and other portions to shrivel and disappear, preceded by ankylosis of the joints. The affected nerves can usually be felt distinctly enlarged and tender. Visceral lesions are not so marked in this as in the other form of the disease, and the patient may retain a considerable degree of health and strength, whilst his sexual powers are not much interfered with. Finally he dies from general debility, or from various complications, but the case may last twenty or more years. IO — 2 148 A MANUAL OF SURGERY The Treatment is still very unsatisfactory. Chaulmoogra oil, administered both internally and externally, is the drug most frequently depended on, but latterly intra-muscular injections of corrosive sublimate have been employed with some success. Actinomycosis. Actinomycosis is a disease mainly of cattle, but occasionally seen in man, due to the growth of the ray fungus (streptothrix actinomyces) . The fungus is transmitted to animals with their food, having been found most often within the husk, or sheath, of barley. It usually attacks the tongue or jaw, turning these into hard infiltrated masses (the ' wooden tongue ' or ' big jaw ' of cattle), in which, after a time, suppuration appears at many foci, producing multiple abscesses, which discharge externally, and leave a diffuse inflammatory mass riddled with sinuses. The pus from such abscesses is of Fig. 22. — Actinomyces in Tissues. (From Crookshank's ' Textbook of Bacteriology.') the usual type, but in addition contains firm yellowish gritty bodies, which can be isolated by the fingers, and consist of masses of the fungus, perhaps undergoing calcareous changes. On microscopic examination of these collec- tions one finds in the interior an abundant mycelial development, in the centre of which are observed numerous small rounded bodies, probably conidia. The fibres, which are arranged more or less in a concentric fashion, terminate peripherally in a layer of radiating, club-shaped bulbous processes, arranged in a more or less symmetrical fashion ; these enlargements are not spores, as was originally taught, but are merely due to a hyaline degeneration of the sheaths of the filaments (Fig. 22). In Man the disease occurs much more commonly than was expected when attention was first drawn to it, and is probably due to direct inoculation with the fungus from chewing or eating fresh corn, or by inhaling the spores with dust during the process of grinding corn. It has been found in the tongue and maxilla, causing diffuse induration and suppuration ; in the lungs, giving rise to destructive lesions very similar to those of tuberculosis, and perhaps ending in localized empyemata; in various parts of the intestinal canal, INFECTIVE DISEASES 149 especially about the caecum ; in the liver, giving rise to a very characteristic reticulated swelling, in which diffuse suppuration occurs ; and in the skin. Wherever situated, the same pathological phenomena manifest themselves, viz., either the formation of a localized tumour, in the jaw possibly simulating an epulis, or of a diffuse infiltrating mass, in which abscesses form ; great destruction of tissue is likely to result. The bones are affected equally with the soft parts, and may become carious. In itself the process is not dangerous, but may become so by involving important organs, or by septic contamina- tion. The commonest site for it is close to the angle of the jaw (Fig. 23), constituting a cervico-facial tumour, the appearance of which is tolerably characteristic. At first the mass has a smooth, regular, and even surface, and merges gradually into the surrounding tissues ; the skin over it is usually hyperaemic. As time passes, little nodular excrescences, with a peculiar yel- lowish apex, form here and there on the surface of the tumour, and these finally soften, point, and burst, giving exit to a small amount of glutinous pus, in which the actinomy- cotic nodules can be demonstrated. "When all the fungus has been discharged, the abscess contracts, and the wound closes. The cicatrization in- duced by the constant repetition of this pro- cess makes the surface of the mass curiously nodular and puckered, and this condition, when present, is almost pathognomonic. Trismus is an exceedingly constant symptom in the cervico-facial form of the disease, coming on early, and being apparently independent of the size of the mass or its involvement of nerves. The Treatment most recently advised consists in the administration of large doses of iodide of potassium (grs. 20 or 30 three times a day), which seems to have almost as great an influence in this disease as in syphilis. This alone may suffice when there is no open wound ; but if open seres are present, surgical measures must also be employed. Extirpation of all the infiltrated tissue, either by the knife or by vigorous scraping, should be undertaken, and the part freely cauterized ; in fact, it must be treated in exactly the same way as a diffuse tubercular mass. This can, however, only be very partially carried out in the visceral affections. Fig. 23. — Cervico-Facial Actinomycosis. (By kind Permission of Mr. Malcolm Morris.) CHAPTER VII. TUMOURS AND CYSTS. Although the term 'tumour' is often used for any abnormal swelling which may be met with in the body, yet for scientific purposes its application is much more limited. A tumour may be defined as ' a mass of new formation that tends to grow or persist, without fulfilling any physiological function, and with no typical termination.' The fact that it has no typical termination dis- tinguishes it from inflammatory overgrowths, which always lead sooner or later to the formation of fibro-cicatricial tissue, or some modification of it ; inflammatory growths, moreover, may dis- appear completely, and often diminish in size temporarily. Pure hypertrophies are excluded by this definition, since they always depend more or less on some increased physiological function, and are composed of an increased development of normal tissues, as, for instance, the blacksmith's biceps. Congenital overgrowth of a limb or portion of a limb also occurs, and is known as 'gigantism'; it cannot be considered a tumour, being merely an exaggerated development of normal tissues. As to the Causes of tumours, but little is known. Probably they are all in the first instance local developments, and may be lighted up by some form of injury or irritation, which determines abnormal development of some of the tissues of the part. Thus, a blow on the breast is often responsible for an adenoma ; the irritation caused by smoking a clay pipe may produce epithelioma of the lip, and many other illustrations readily suggest themselves. Moreover, even if, as supposed by some pathologists, the carcino- mata and sarcomata result from infection, it is probable that some local irritation or breach of surface is needed to allow entrance to, or determine the activity of, the organisms. The hereditary nature of some malignant tumours is sometimes thought to be evidence of a constitutional origin ; but although it may indicate a predisposition of the patient to their development, some local condition is usually found to determine it. Cohnheim has sug- gested that tumours may be due to excessive growth in small portions of undeveloped and undifferentiated embryonic material, TUMOURS AND CYSTS 151 or, as he terms them, foetal residues, left among the normal tissues. These remain in a condition of suspended activity, until some local lesion excites their development. As an illustration may be mentioned the fact that many branchial cysts do not appear till adult life ; evidently the embryonic cells were present from birth, but required some special stimulus to call them into activity. It is also probable that the presence of cartilage in many tumours of the parotid and testis may be explained in a similar way ; in the former case it is due to the inclusion of a portion of Meckel's cartilage; in the latter, to the fact that the testis develops in the posterior abdominal wall not far from the notochord, and evidently cartilaginous cells from the protoyertebrse developed around this structure become included within it. Tumours may be divided into two great classes from a clinical standpoint, viz., the benign and the malignant. Benign or Simple Tumours are characterized by the develop- ment being strictly local, by their more or less exact limitation, being frequently encapsuled, and by their method of growth, which results from a proliferation of all the cells constituting their structure. There is no tendency to infiltrate or invade surround- ing tissues, which are merely pushed aside and compressed ; pain and atrophy are sometimes caused by this pressure. The capsule is formed by an ensheathing layer of fibro-cellular tissue, the outcome of the chronic irritation and inflammation engendered by the growth and development of the mass ; hence enucleation is easy, and recurrence uncommon. They are not unfrequently multiple, and may be hereditary : but these characters are no evidence of a constitutional taint. Malignant Tumours, unless removed by operation, are almost invariably fatal. The following are the chief characteristics of malignancy : (1) The primary growth is usually single, rarely multiple. (2) It progresses steadily and constantly, but with varying rapidity in different cases. (3) The local development is characterized by an infiltration of the surrounding tissues, which are gradually replaced by the tumour substance. A capsule is rarely formed, or, if at all, only in the early stages, and thus the limits of the growth are not clearly defined. Moreover, many varieties spread locally along the efferent lymphatics, and hence, although the growth may appear to have been completely removed, recurrences are very common, owing to the non-removal of these prolongations (or, as they are termed by the lay public, ' roots ') of the disease into apparently normal tissue. If a malignant tumour, with all its ramifications, is completely removed, it does not recur. The impossibility of knowing whether all the growth has been removed, or how far it has extended into the surrounding tissues, is responsible for the frequent recurrences. (4) When a malignant tumour invades the skin, it usually leads to ulceration, and then not uncommonly a i 5 2 A MANUAL OF SURGERY foul fungating mass results (the fungus hamatodes of the older pathologists). (5) Secondary deposits are often found in neigh- bouring lymphatic glands or distant viscera. (6) An apyrexial cachexia develops in the later stages, partly due to the pain, partly to the pressure of the growth on important structures, and in part to the absorption of toxic products from the tumour. The patient is thin and emaciated, the face drawn and with an expression of pain on it ; the appetite is impaired, and the skin often sallow and earthy-looking. (7) Finally, death ends the scene, after a longer or shorter period of suffering. The degree of malignancy varies with different tumours. In some the local phenomena predominate, whilst in others the constitutional symptoms are the more important. Thus, rodent ulcer is slow in its progress, and produces no visceral deposits ; it destroys life merely by implication of vital parts. Melanotic sarcoma, on the other hand, may produce only a small primary growth, but the most extensively diffused secondary deposits may form in the viscera. The sarcomata are very frequently dissemi- nated by the blood-stream, and hence secondary growths are not common in the lymphatic glands, whilst the carcinomata spread by means of the lymphatics. Even among the latter consider- able differences are met with ; thus, in glandular cancer secondary growths occur both in the lymphatics and the viscera ; whilst in squamous epithelioma neighbouring lymphatics are affected, but the viscera generally escape. The term semi-malignant is some- times applied to those growths which are on the borderland between the malignant and benign. The Classification of Tumours is conducted along lines partly anatomical, partly embryological, and on these grounds the following groups are described : I. Tumours derived from mesoblastic tissue, constituting what is known as the Connective Tissue Group : (1) Embryonic connective tissue tumours : (a) Myxoma (mucoid tumour). (b) Sarcoma. (2) Fully-developed connective tissue tumours : (a) Lipoma (fatty tumour). (b) Fibroma (fibrous tumour). (c) Chondroma (cartilaginous tumour). id) Osteoma (bony tumour). (e) Myoma (muscle tumour). (/ Neuroma (tumour in connection with nerves). (g) Angioma (tumour composed of bloodvessels). (h) Odontoma (tumour connected with the teeth). (i) Lymphadenoma, or lymphangioma (tumours of lymphatic origin). TUMOURS A±JD CYSTS 153 II. Tumours derived from epiblastic or hypobiastic structures, or Epithelial Tumours : (ij Innocent varieties : (a) Papilloma (wart-like growth). (b) Adenoma (glandular new formation). (2) Malignant growths, or the carcinomata : (a) Epithelioma (cancer of skin or mucous mem- brane). (b) Rodent ulcer (cancer of sebaceous glands). (c) Columnar carcinoma (cancer arising from tubular glands, e.g., Lieberkiihn's follicles, or from ducts lined with columnar epithelium). (d) Acinous carcinoma (cancer arising in glands with spheroidal epithelium). L The Connective Tissue Group of Tumours : (r) Tumours composed of Embryonic Connective Tissue. Myxoma. — A myxoma is a tumour consisting of connective tissue cells, surrounded and separated from each other by an Fig. 24. — Myxomatous Tissue, showing the Stellate Cells with their Branching Processes separated by Translucent Intercellular Substance. (Tillmanns.) intercellular substance of a mucoid character ; a similar type of material occurs normally in the substance of the umbilical cord. The cells are usually polygonal in shape, and present long branched processes which interlace with those from adjacent cells (Fig. 24). The intercellular substance is homogeneous and translucent, con- taining wandering connective tissue corpuscles, and traversed by bloodvessels ; the density of the tumour varies inversely with the amount of intercellular substance. It is not uncommon for this form of growth to be associated with sarcoma, and hence a thorough and early removal of the mass is always advisable. 154 A MANUAL OF SURGERY Myxomata occur as rounded tumours, perhaps tabulated, in the neighbourhood of mucous membranes — e.g., the face, intestine, and bladder ; they also grow in the sheaths of nerves, and are the commonest form of simple tumour of the spinal cord. Mucous polypi of the nose were formerly considered of this nature, but at the present time rhinologists look on them as merely consisting of cedematous granulation tissue. Sarcoma (Greek, U \ type, and the term 'myeloma' -^ S^.-.i'V'V/-- ;V "l>> ■ % J/ has been suggested for them, <§> * ».^ J*^ ^vC*? -* .1 -«% ? -** as indicating in measure their '; % ! -."V ^\^ '- jf 1'i f nature and structure. &^i i. •, ., " AA (d) Alveolar Sarcoma (Fig. 28) , * i ";-- & | ' i; /^^%^ y %^'"^\ » is a variety in which the cells % . %s ••'?/•> ' .-s'.VjVJ^"}* are grouped together in alveoli, separated by a distinct fibrous stroma. On microscopic ex- •<-,'»'?; * ^Z"~k^*3^'S® amination they closely resemble ^ f ® < &"%f'f(" ! &*'' K cancer ; but on carefully pen- " ? cilling a section with a camel's- Fig. 28. — Alveolar Sarcoma. hair brush, it will be found (Tillmanns.) that the stroma sends delicate The individual cells in the alveoli are prolongations between each of here apparently lying in close con- fY 11 t-u- <- tact, but in reality there is a certain the cells. I his variety of amount of intercellular substance tumour is most commonly found placed between each of them. growing from the skin, and is occasionally of a melanotic nature, and always very malignant. (e) Melanotic Sarcoma is perhaps the most virulent of all this TUMOURS AND CYSTS 159 group of tumours. It almost invariably originates from pigmented structures, e.g., the deeper layers of the skin or the retina. It is, however, sometimes met with growing from the mucous mem- brane of the lips and gums. It consists of round or spindle cells, often arranged in alveoli, whilst in other cases club-shaped pro- cesses of epithelium may penetrate into the subjacent tissues, thus causing it to resemble epithelioma. The most prominent feature is the brown colour, owing to a deposit within the cells of granules of melanin. The amount of this pigmentation varies consider- ably, some tumours being of a deep brown or brownish-black colour, and then consisting of flattened plaques, whilst others are of a papillomatous nature, and show but slight discoloration, especially if growing rapidly. The tumour soon spreads to the nearest lymphatic glands, and secondary deposits in the viscera follow. So great is the malignancy, that, according to Erichsen, if the primary growth has attained the size of a filbert, local treatment is of but little value. The original tumour is often not very large, and the secondary deposits are similarly characterized by their number rather than by their size, scarcely an organ in the body being free. Of late years a more benign type of melanosis has been described, and is now well recognised by dermatologists. It usually spreads from a congenital mole as a deeply pigmented patch, which may extend over an area of several square inches, and presents at first no sign of induration or infiltration ; in this stage microscopic examination reveals no change in texture except pigmenta- tion of the deeper layers of the cutis vera. Sooner or later, a tumour develops in the centre of this patch, and may be either a sarcoma or a cancer, but more frequently the former. It is not very rapid in its course, but if left alone will finally become disseminated. In treating this type of melanosis, it is essential to remove every portion of pigmented tissue as well as the tumour. Some degree of uncertainty exists as to the position which should be assigned to the tumour known as an endothelioma ; it originates in mesoblastic tissues, but is somewhat similar in nature to the cancers, for which, indeed, it has often been mistaken. It arises from the endothelial cells of serous membranes, lymphatics or bloodvessels, and usually consists of columns of cells supported by a fibro-cellular stroma. It sometimes originates from the pleura or cerebral membranes, but may also be observed in glandular organs, such as the breast, parotid, testis, or ovary. On serous membranes it may give rise to large tumours, from which secondary deposits in glands or viscera are after a time developed, but the rate of dissemination is not great. In glands the tumour often starts as a more or less cylindrical proliferation of the endothelial cells of the arterioles or lymphatics ; this gradually extends along the vessel and usually leads to its obliteration, whilst either the cells or the surrounding tissues undergo a mucoid or hyaline change; this arrange- ment in cylinders or columns led to the name cylindroma, which was often applied to it. The tumour runs a slowly malignant course, comparable to that of some of the less virulent sarcomata, and its nearest homologue is probably an angio-sarcoma. The Treatment of sarcoma consists in its removal as early and completely as possible. This may be a simple matter in cases where the tumour is encapsuled, but even then recurrence is very i6o A MANUAL OF SURGERY likely to follow unless the capsule is also taken away, and a considerable margin of tissue beyond it. Where, however, the growth is more diffuse, the only hope lies in cutting widely, so as to get beyond its furthest limits ; the prognosis of such cases is very bad. In hopelessly inoperable cases somewhat similar measures have been employed as for the similar stage of cancer (vide p. 145). Several cures have now been recorded from the use of Coley's fluid, which consists of a sterilized culture of the Streptococcus erysipelatis and Micrococcus prodigiosus in bouillon. This fluid is intensely toxic, and the injections, commencing with doses of half a minim, are gradually increased up to 7 or 8 minims ; severe reaction usually follows, and the surgeon should aim at obtaining two or three such effects each week. The fluid is introduced partly into the abdominal wall, and partly into, or around, the tumour. In favourable cases the growth gradually dwindles. The spindle- celled sarcomata are apparently the most suitable for this treat- ment, whilst ossifying and melano- sarcomata are but little, if at all, affected. (2) Tumours consisting of Fully-developed Connective Tissue. Lipoma. — A fatty tumour is an overgrowth of fibro-cellular On microscopical examination it -- tissue, infiltrated with fat. differs in no respect from ordinary adipose tissue, and is not very freely sup- plied with bloodvessels. When localized (Fig. 29) it forms a tumour, soft and semi-fluctuating in consistence, rounded and lobulated in outline, and if occurring in the subcutaneous tissues, the skin becomes dimpled on moving it from side to side, owing to the fact that fibrous trabeculae pass from the capsule to the skin. The growth is usually encapsuled and freely movable ; but if exposed to pressure or friction, as when situated on a man's shoulder and rubbed by the braces, it becomes firmly adherent to surrounding structures. Such growths are either single or multiple, in the Fig. 29. — Lipoma, showing Characteristic Lobulated Outline. (From King's College Museum.) TUMOURS AND CYSTS 161 latter case perhaps occurring in hundreds, and are most com- monly found about the trunk or the upper extremities. It has been stated that lipomata travel from one point of the body to another by the action of gravity, but it is somewhat doubtful whether this ever occurs. Occasionally subcutaneous tumours become pedunculated and pendulous. Deep inter-muscular lipomata are sometimes met with, and the diagnosis may then be uncertain, since their mobility and lobulated outline are masked by the superjacent tissues ; they have even been mistaken for sarcomatous growths. Still more difficult of recognition are those known as parosteal lipo- mata, growing from the outer surface of the peri- osteum. They are often congenital, and appear as soft swellings, lying beneath the muscles in close proximity to a bone and suggesting the presence of a chronic abscess. We observed one a little time back- growing just above the angle of the jaw beneath the masseter. Pericranial lipoma is of a somewhat similar nature. It is usually congenital in origin, and often the cranium is per- forated and a connec- tion established with the meninges. An angioma- tous element is some- times present in these growths. By the term Diffuse Lipoma (Fig. 30) is meant a fatty infiltra- tion of the subcutaneous tissues of some region of the body, particularly beneath the chin and at the back of the neck, and more rarely in the pubic region. These growths are often multiple and almost always symmetrical. They usually occur in individuals who drink freely and take but little exercise. Their size diminishes on limiting the amount of alcohol and making the patient do physical work. Occasionally the connective-tissue basis of a lipoma undergoes modifications ; e.g., it may become increased in amount, con- stituting a Fibro-lipoma, or be transformed into mucoid tissue, 11 Fig. 30. — Diffuse Lipoma. 162 A MANUAL OF SURGERY giving rise to a Myxo-lipoma ; or, again, the vessels may become dilated, originating a Nsevo-lipoma ; and even a Sarco-lipoma may develop. Localized or diffuse overgrowths are often met with in the sub -peritoneal fatty tissue, constituting Subserous Lipomata. They occur not unfrequently in the lower part of the abdomen, and may extend into the inguinal and crural canals, forming the so-called fatty tumour in these parts. By their traction a process of peritoneum may eventually be drawn down, and a true hernia produced. A similar condition occurs in the anterior abdominal wall, small pedunculated masses of fat projecting through congenital or acquired openings in the linea alba or linea semilunaris ; these are sometimes known as Fatty Hernia of the Linea Alba, and are often painful. Lipoma Arborescens is the term applied to a villous outgrowth of fatty tissue, met with in the interior of joints, and usually associated with osteo-arthritis. There is often a considerable increase in the amount of intra-articular fluid, and the condition has then been designated ' synovitis lipomatosus.' The Treatment of lipomata consists in their removal. When they are loosely encapsuled, this is a very simple matter, all that is required in many cases being to squeeze the mass forwards between the thumb and finger, making the skin tense over it, and then to incise the capsule freely, when the tumour almost jumps out ; but if there are many adhesions it may not be so easy. In the diffuse forms dietetic and hygienic measures should first be tried. Should an operation be required, it is well to cut through the whole thickness of the tumour at once, and deal with each half separately, dissecting it away from its deep attachments. Fibromata consist of overgrowths of fibrous tissue ; they were formerly divided into two groups, the hard and the soft, and although there is no essential difference between them, it is a useful clinical distinction. The Hard Fibroma is composed of firm dense tissue, which creaks on section with the knife, the exposed surface showing numerous trabecular of glistening fibres, similar in character to those met with in a tendon (Fig. 31). Microscopically, interlacing fibrillae are seen, which are sometimes arranged concentrically around the bloodvessels ; there are but few nucleated cells in the more slowly growing tumours. The vascular supply is somewhat defective, although dilated veins are often present, especially in the capsule, and sometimes in the substance of the mass ; these, if opened by ulceration, may lead to profuse haemorrhage. Hard fibromata are met with in the form of epulis, fibrous polypus of the nose, keloid, and not uncommonly in connection with the sheaths of nerves. Soft Fibromata develop as localized overgrowths of the sub- TUMOURS AND CYSTS 163 cutaneous fibro-cellular tissue, or as the so-called Molluscum fibrosum of the skin. In the latter case many different forms of the growth are met with ; sometimes a development of small nodules occurs, scattered widely over the surface, usually pinkish, and with the skin over them somewhat corrugated ; these may be associated with changes in the underlying nerves (p. 168). It also exists in the form of pendulous folds, perhaps involving a large area of the trunk ; the so-called pachydermatocele of the scalp is of this nature. Chondroma. — Cartilaginous tumours are met with growing either in connection with bones or in certain soft tissues. They Fig. 31. — Section of Hard Fibroma. (Royal College of Surgeons' Museum.) consist of hyaline cartilage, which, instead of being uniform in texture and devoid of vessels as at the articular ends of bones, occurs in the form of pellets or nodules of varying size, held together by vascular connective tissue, which may even penetrate into the substance of the cartilage. The cells are also less regular in shape than is the case with normal cartilage, and are not arranged according to any definite plan. Chondromata are liable to become calcified, and even ossified. When large, the central parts may undergo a mucoid change, giving rise to a cavity which, if sepsis is admitted, becomes 11 — 2 164 A MANUAL OF SURGERY exceedingly foul. They are not uncommonly accompanied in their growth by sarcomatous and other elements. When growing from the long bones, chondromata usually start from beneath the periosteum, and are independent of the epiphy- seal cartilage, although it has been suggested by Virchow that they may originate from a nodule of cartilage which has been dis- placed from its usual situation during an attack of rickets. They constitute firm lobulated encapsuled tumours, and give rise to no pain, except when they encroach on neighbouring nerves. They often attain a great size. The growth may extend secondarily into the medullary canal, and thus cause expansion of the bone ; or it may erode the compact tissue, and lead to spontaneous fracture. Amputation of the limb will probably be necessary, unless the case comes under observation in the early stages, when the tumour can be gouged or scraped away. Chondromata also originate from the smaller bones, usually from those of the hand (Fig. 32). In such cases the growth commences in the interior, close to the epiphyseal cartilage ; several tumours may be present in the same indi- vidual. The bone is expanded by the growth, and the parts become much de- formed. Treatment consists in incising the capsule, and scooping out the carti- laginous tissue, a proceeding which may result in defective growth and subsequent deformity. In the later stages, however, amputation is inevitable. Chondromata are also found in the soft parts, especially affecting the parotid and submaxillary glands, and the testes. In the parotid gland they are usually asso- ciated with mucous and fibrous tissue, a few glandular elements being also embedded in the mass. They develop from the capsule of the gland, or immediately beneath it, and are usually simple in nature, though occasionally they become sarcomatous. Submaxillary chondroma is frequently an almost unmixed cartilaginous tumour. Overgrowths of cartilage, known as Ecchondroses, occur around the articular cartilages in connection with osteo-arthritis ; they also arise from the cartilages and septum of the nose, and from the laryngeal cartilages. Some of the loose bodies which form in joints are of a similar nature. Osteoma. — Bony tumours are of two chief forms : the cancellous and the ivory. Cancellous Osteomata are usually met with growing near the articular end of a bone, being derived originally from some iso- lated portion of the epiphyseal cartilage, which has perhaps been Fig. 32. — Multim-e Chondromata of the Fingers. PLATE IV Exostosis of the Radius. This growth occurred in a young man aged twenty-three years. It will be noticed that it has caused great deformity of the ulna, and, indeed, apart from the skia- gram, one might have supposed that it had originated from that bone. To face •/>. 165.] TUMOURS AND CYSTS 165 separated from its original connection after an attack of rickets. It is well known that in this affection irregular outgrowths from the epiphyseal cartilage occur, and if one of these near the peri- phery of the bone becomes shut off from its epiphyseal attachment, it is easy to understand its development into a tumour, which consists of cancellous bone, capped by a layer of hyaline cartilage, from which it grows (Fig. 33). It is pedunculated or sessile, and may attain to a large size, leading to considerable deformity (Plate IV.). It necessarily develops in young people, and may be congenital. As the individual grows, the basis of attachment may become separated from the epiphysis to an extent corre- sponding to the amount of growth which has taken place at that spot, or it may still remain attached to the epiphyseal line. As a Fig. 33. — Diagrammatic Represen- tation of Cancellous Exostosis growing from the lower end of the Femur. Fig. 34. — Subungual Exostosis. _. . .,', '. . , . (Bland Sutton.) Its proximity to the epiphyseal car- tilage is indicated, as also its carti- laginous covering and the bursa which occasionally lies over its summit. rule its growth and development cease at maturity, when the cartilage covering it, as well as the epiphyseal cartilage, ossifies. A bursa occasionally forms over the most prominent part of these tumours as a result of friction or pressure, giving rise to the con- dition known as Exostosis Bursata ; this cavity may communicate with the joint. An effusion of blood or serum into the bursa may be the first evidence of the existence of such a growth. Multiple exostoses are not unfrequently met with, and are then often hereditary. The most common situation for such a tumour is the inner condyle of the femur, close to the adductor tubercle, but they are not rare on the inner aspect of the mandible. The Subungual Exostosis (Fig. 34) develops as a rounded, cherry-like swelling under the nail of the great toe. It is very painful, and should be treated by removing the nail, incising the tissues over 1 66 A MANUAL OF SURGERY it down to the bone, and clipping it away with cutting pliers. Fig. 35 represents a skiagram of an exostosis growing from the proximal phalanx of the thumb. Ivory Exostoses develop most frequently on the inner or outer aspect of the cranial bones, especially affecting the orbit, external auditory meatus, antrum, and frontal sinus (Fig. 36). They consist of masses of very dense compact tissue, covered by periosteum, from which they grow. They are usually lobulated, and when situated in the frontal sinus, or growing from the under surface of the skull, may give rise to serious symptoms from irritation or compression of the brain or its membranes. In a few cases necrosis has resulted, and they have sloughed out, thus bringing about a spontaneous cure. Occasionally diffuse overgrowth of the bones of the skull (Hyperostoses) are met with, affecting either the calvarium alone, being then probably syphilitic in nature, or the facial and cranial bones, as in leontiasis ossea. New formation of bone sometimes occurs in the substance of tendons which are exposed to irritation or excessive action, e.g., the tendon of the adductor longus in riders, producing what is known as ' the rider's bone,' but this is inflam- matory in origin. The Treatment of osteomata consists in their removal where possible. This may be tolerably simple in the case of the cancellous osteomata of the limbs, but is sometimes a most formidable proceeding when dealing with sessile compact exostoses of the calvarium. Myoma.— Myomata almost always consist of unstriped muscle fibres (Leiomyoma or fibromyoma), forming rounded and often en- capsuled tumours, the cells of which are long and fusiform, and contain a rod-like nucleus. Bundles of these cells are grouped together into fasciculi, which are arranged more or less regularly. The tumours themselves are not very vascular, but vessels of considerable size are found in the capsule. It is often difficult to distinguish these tumours microscopically from fibromata on the one hand, and from fibro-sarcomata on the other. From the former they are known by the fact that individual cells can be recognised, and by the absence of wavy tendinous fibrillae ; from the latter the distinction depends on the facts that other types of tissue may occur in the sarcoma, and that the growing edge is Fig. 35. — Skiagram of Exostosis growing from the Base of Proximal Phalanx of Thumb, showing Open Cancellous Texture and Origin near the Epiphy- seal Cartilage. TUMOURS AND CYSTS 167 usually more or less embryonic in character, whilst a myoma is of the same structure throughout. Again, in a myoma the bloodvessels have distinct and definite walls, and in a sarcoma they are simply clefts or passages in the tumour substance. Myomata are met with in the uterus and prostate, and occasion- ally in the walls of the alimentary canal and in the ovary. Secondary changes sometimes occur, e.g., mucoid softening, as in fibro-cystic disease of the uterus, calcification, ulceration with Fig. 36 — Ivory Exostosis growing from Frontal Sinus, and encroach- ing both on the Orbit and the Cranial Cavity. (Bland Sutton.) (From specimen in the College of Surgeons' Museum.) profuse haemorrhage, and possibly consequent septic inflammation, whilst malignant disease may supervene. For the characters of the prostatic myomata, see Chapter XXXVII. Tumours consisting of striped muscle fibres (Rhabdomyoma) have been described, but are exceedingly rare. Neuroma. — True Neuroma is seldom met with, only five un- doubted cases being on record. It is formed by a mass of newly- formed ganglion cells and nerve fibres, which may be medullated or not. In all but one case it involved the sympathetic system, and occurred in children or young people. The tumours may attain considerable dimensions, are often multiple, and may be quite soft, like a lipoma, or firm. They are insensitive and inno- cent, and may be freely removed. False Neuromata, or those developing in connection with the sheaths of nerves, are more common, and may be described under three headings : 1. Solitary Pseudo-Neuroma, which may be innocent or malig- nant, the former being a fibroma or myxoma, the latter usually a 1 68 A MANUAL OF SURGERY Fig. 37. — Pseudo - Neuroma : Fibrous Tumour growing from Nerve Sheath, and causing the Fibres to be widely stretched over it. sarcoma. It may project from one side of the nerve, or more frequently causes the nerve fibres to be separated and spread out over it (Fig. 37). It moves more freely in a direction at right angles to the axis of the nerve than along its course. When de- veloping from a small nameless subcutaneous twig, it is termed a painful subcutaneous nodule, and then gives rise to intense pain of a neuralgic type, especially when compressed or irritated, or when exposed to cold. A false neuroma growing from a larger mixed nerve (trunk neuroma) is less painful, because there are relatively fewer nerve fibrillae, and the mass is less exposed. A growth on a pure motor nerve, though sensitive, is not associated with radiation of pain. It is uncommon for tumours of this nature to lead to complete paralysis or anaesthesia, unless they are of a malignant nature. They occur most frequently in healthy adults, and in women a little more commonly than in men. Treatment. — A neuroma, if painful, should be removed, care being taken, if possible, not to interfere with the continuity of the nerve fibrillae. If this cannot be accomplished, the nerve must be divided, and the ends united by immediate suture. 2. Diffuse or Generalized Neuro- fibromatosis [Recklinghausen 's disease). — This consists of a diffuse thickening of the nerve sheaths, causing multiple elliptic or spherical tumours, or a generalized enlargement. The growths may be encapsuled and limited or not ; they may be few in number, or hundreds may be present, and they are usually whitish and firm in texture. They originate from the endoneurium of the primary nerve bundles. Any part of the peri- pheral nervous system may be affected, including the sympathetics, but it is most common in connection with the cranial nerves and the large plexuses of the trunk. The actual symptoms are some- times very slight, but the tumours may be sensitive to pressure, and some one of them, more exposed than the others, may be ex- quisitely tender. Motor phenomena are rare, and paralysis is usually due to involvement of the nerve roots in the spinal canal, or to the supervention of sarcoma, which is a not uncommon ter- mination. The disease may start at any time during life, and although progressing slowly, sooner or later terminates fatally. No known treatment is of any avail, but should any particular tumour become large and tender, it may be removed. TUMOURS AND CYSTS 169 In connection with this disease one frequently finds a large development of fibrous growths of the skin, similar to what we have already described as molluscum fibrosum. On careful microscopical examination of specimens stained by Weigert's method, the presence of nerve fibrillae can be demonstrated in these growths, showing that they are really neuro-fibromatous in origin. So excessive does this overgrowth occasionally become that a form of elephantiasis is produced, e.g., the irregular hyper- plasia of the scalp tissues known as a pachydermatocele. A Plexiform Neuroma is a special modification of this process, occurring congenitally or in young people, and usually involving the trigeminal or superficial cervical nerves ; it may be associated with the former condition. The overgrowth is of a softer, more gelatinous type (myxo-fibromatous), and the resulting tumour consists of a plexus of thickened, tortuous, vermiform strands, of soft consistence, held together by loose connective tissue, but easily separable into their constituent elements, which are of a nodulated character, so that the dissected mass looks " not unlike grains of boiled tapioca on a string" (Alexis Thomson). The plexiform neuroma is almost always subcutaneous, but often dips deeply between and into the substance of muscles. When limited in extent, the growth may be dissected out, and this is usually required for cosmetic purposes. The final prognosis is rather better than in the former condition, as secondary sarcomatous changes are rare. 3. The bulb formed upon the proximal end of a nerve after its division is sometimes described as a neuroma (Traumatic Neuroma). It consists of a mass of fibro-cicatricial tissue containing spaces, coiled up within which are numbers of newly-formed axis cylinders (p. 328). They are almost always present in amputation stumps, but are not painful unless adherent to the periosteum of the neighbouring bone, or to the cicatrix, when every movement of the nearest joint causes traction upon them, and induces severe neuralgia. Angioma. — Several distinct varieties of tumour consisting of dilated arteries or veins exist, but the term angioma is applied only to those in which a new formation of bloodvessels occurs ; hence aneurisms and varicose veins are not included in this catagory. Three main types of angioma may be described: (1) The simple naevus ; (2) the cavernous naevus ; and (3) the plexiform angioma. The Simple Naevus is exceedingly common, and consists of a mass of dilated capillaries, bound together by a small amount of connective tissue. It is usually congenital, and may increase rapidly in size during the first few months of life. It is located in the skin, or may also involve the subcutaneous tissues, but the tubular form of the constituent vessels always remains. It may 170 A MANUAL OF SURGERY be of a bright red colour or of a dusky tint. For a fuller account, see Chapter XI. If untreated, simple naevi may persist unchanged, or may disappear ; in a few instances they increase rapidly in size, either early or late in life, sometimes giving rise to a considerable vascular growth, purplish in colour, and occasionally becoming prominent and pendulous. Such a tumour is soft and easily compressible, being in reality a cavernous ulcerate, and profuse haemorrhage may result, in electrolysis, if excision is impracticable. The Cavernous Nsevus consists of dilated spaces, where the tubular form of the constituent vessels is lost, the arteries usually opening directly into thin-walled cavities lined with endothelium without the intervention of capillaries (Fig. 38). The tumours are thus more or less erectile in nature, somewhat resembling the corpus cavernosum. They are angioma ; it may Treatment consists met with in the skin and sub- cutaneous tissues, constituting diffuse or circumscribed tumours of a reddish-blue colour, which can be emptied on pressure, but rapidly refill when such is re- moved, and in which pulsation is occasionally present. A similar condition arises in the viscera, especially the liver, and then is always acquired, and it is not difficult in suitable cases to demonstrate that it has been formed by a dilatation of the capillaries between the lobules, the liver substance meanwhile disappearing by a process of simple atrophy. Occasionally a cavernous angioma undergoes a process of spontaneous cure as the result of some inflammatory affection similar in nature to phlebitis, a non-vascular fibro-cystic mass remaining. Under the term Plexiform Angioma may be included the cirsoid aneurism, or aneurism by anastomosis, the former term being applied by some authors to tumours consisting of large vessels, and then most commonly seen about the scalp and face, and the latter to a congeries of small vessels. The treatment is always a matter of considerable difficulty (see Chapters XVIII. and XXIV.). Odontoma. — Tumours originating from some abnormal condi- tion of the teeth or teeth-germs are known as ' odontomes.' Bland Sutton, in his work on tumours,* has described seven different varieties, several of which are, however, rarely met with * Bland Sutton, 'Tumours and Cysts.' Cassell and Co. Fig. 38. -Section of Cavernous Angioma. TUMOURS AND CYSTS 171 in man. We can only deal here with the more important of these, and must refer our readers to Chapter XXV. and to Sutton's book for a fuller description. (1) Epithelial Odontome. In this condition, formerly known as ' fibro-cystic disease of the jaw,' the mandible is most commonly affected. A tumour forms, consisting of spaces lined by epithelium, which are developed as irregular outgrowths from the enamel organ. It occurs most frequently in young people, and may give rise to a growth of enormous size. (2) Follicular Odontomes, or, as they are often termed, ' dentigerous cysts,' are produced by the development of a cavity around a misplaced or ill-developed tooth of the permanent set, which often lies horizontally, so that its eruption is impossible. (3) Fibrous Odontomes are the result of a thickening and condensation of the connective tissue around a tooth sac. They are most frequently observed in the lower animals, but are also said to occur in rickety children. (4) Radicular Odontome is the term applied to a tumour composed of cement, developing at the root of a tooth. It gives rise to severe pain, and may result in septic inflammation of the surrounding bone. (5) Composite Odontomata consist of a con- glomeration of the various forms of tissue entering into the formation of a tooth, and developing in the neighbourhood of the jaw. They may be very large, and probably some of the bony tumours described as osteomata of the antrum are of this nature. Lymphadenoma and Lymphangioma. — The primary tumours developing in lymphatic glands are described in Chapter XII., as also the conditions arising from the dilatation of lymphatics. II. Tumours derived from Epiblastic or Hypoblastic Structures. These are either innocent or malignant in nature, the innocent tumours being the papillomata and adenomata, and the malignant the carcinomata. Papillomata consist in an outgrowth of the papillae of the skin or mucous membrane, which may be simple in nature, or compo- site from the development of lateral offshoots, giving rise to a cauliflower-like mass ; they may be sessile or pedunculated. The connective tissue of the papillae, with its vessels, also extends into the growth, which is sometimes exceedingly vascular. The epithelium never dips down into the subcutaneous or submucous tissue, the growth being only centrifugal in development, and not centripetal, as in the case of the epitheliomata. Not unfrequently, however, a papilloma which has become irritated may take on malignant action. Clinically, a papilloma is distinguished from an epithelioma by the base being free from infiltration. Papillomata of the skin are met with in the form of hard excrescences, such as warts or corns ; but if growing from 172 A MANUAL OF SURGERY moist parts, as from the prepuce, they may be soft and vascular. Occasionally warts may grow to such an extent as to constitute horn-like projections or cauliflower-like growths. Papillomata of the mucous membranes are usually villous in character, constituting long, fimbriated tufts, covered with a thin layer of epithelium, and containing delicate bloodvessels, which readily give way, and may lead to considerable haemorrhage. They are most commonly observed in the bladder, but occasion- ally in the pelvis of the kidney, and on the intestinal mucous membrane, especially in the rectum. They also occur on the true vocal cords, and are then wart-like, and hard in consistency. Growths of a very similar nature, but somewhat more solid in texture, are found within the ducts or acini of glandular viscera, such as the breast. Condylomata and mucous tubercles, develop- ing in the course of syphilis, are also of a papillomatous nature. Adenomata consist of new growths arising in connection with secreting glands, and in structure simulating somewhat closely the organs from which they rise. They differ from them, however, in that they are incapable of producing the characteristic secretion, that they are devoid of ducts, and that the mimicry is incomplete, since the alveoli are less perfectly developed, and may be entirely occupied by several layers of epithelial cells. The epithelium, however, does not pass beyond the basement membrane into the connective tissue, and hence they also are distinguished from can- cerous tumours by the new formation being centrifugal, and not centripetal, in its growth. A variable amount of connective tissue is always present, and may be normal in texture, or may mani- fest various modifications. Adenomata are usually encapsuled, being merely connected with the original gland by a pedicle, through which the vessels enter. When growing from mucous membranes, they are sometimes pedunculated, as in the so-called polypus recti. The alveoli in some cases become distended with effusion, giving rise to a cysto-adenoma or adenocele. They are absolutely free from malignancy, except when, as occasionally happens, the connective tissue undergoes a sarcomatous change, whilst sometimes carcinoma supervenes. When of large size, they may cause trouble by compression of important structures. Any glandular organ may become affected with adenoma, and several varieties will be described hereafter in the chapters on the breast, thyroid body, prostate, testis, etc. They are also found as congenital tumours in connection with the thyroid body, post-anal gut, and possibly the kidney. The growth is usually slow, but occasionally becomes rapid. Carcinoma. — The malignant forms of epithelial new growth are known as cancers or carcinomata, of which the following varieties are described, viz., epithelioma, rodent ulcer, columnar carcinoma, and glandular or acinous cancer. The term 'colloid cancer' is TUMOURS AND CYSTS 173 also used to indicate a degenerative change occurring in some forms. The essential character of a cancerous growth consists in an unlimited multiplication of the epithelial elements of the organ attacked. In some cases this may result in the formation of a superficial outgrowth of a papillomatous type, while deep pro- cesses or columns of cells advance into the tissues along the lymphatic channels, and even burst through the basement mem- brane of glandular alveoli. The irritation of this development leads to an infiltration of the surrounding structures with round cells, which are presumably inflammatory in origin, by the agency of which the normal tissues are disintegrated and removed, and a stroma of variable density develops around the epithelial outgrowths. Hence all cancerous tumours may be said to consist of a fibro-cellular or fibro-cicatricial stroma (Plate V., Fig. 1), within the alveoli of which are collections of epithelial cells, sometimes arranged in a methodical manner, but more often packed irregularly together, and with no intercellular tissue between them. The alveolar spaces are in reality dilated lymphatics, and hence it is easy to understand that carcinomata are disseminated along these vessels ; the cancer cells are epithelial in origin, and of very variable size and shape ; but they always retain more or less the characters of the epithelium from which they are originally developed, so that, e.g., a squamous epithelioma is never derived from a part covered with columnar epithelium, or vice versa. Bloodvessels ramify through the stroma, and are more or less abundant according to its density. The tumours are not necessarily tender to the touch, but a consider- able degree of pain, usually of a neuralgic type, is often com- plained of, especially in the harder forms, where tissues get dragged upon by the contracting stroma. iEtiology. — Formerly cancer was considered to be of constitu- tional origin, resulting from some morbid condition of the blood, and in favour of this view the immense difficulty of eradicating it was educed, as also its hereditary nature in many cases. It is now, however, generally admitted to be primarily local in origin, and probably the result of the inoculation and development of some specific organism. The chief arguments in favour of its local origin are as follows : (1) That it often occurs in individuals who, up to the time of its onset, have been in perfect health ; (2) that cachectic symptoms only manifest themselves in the later stages of the disease, being then readily explicable by excessive pain, the absorption of septic discharges, loss of blood, or possibly the toxic effect of some material absorbed from the growth ; (3) that the original neoplasm is always single, multiple tumours being the result of infection from the primary growth ; (4) that some definite focus of local irritation may frequently be traced as the cause of the tumour — e.g., the irritation of the lip by a short 174 A MANUAL OF SURGERY clay pipe, the presence of ulceration or cicatrices of the tongue, resulting from ragged teeth, syphilitic affections, etc. It is also interesting to note that cancer usually involves the intestinal canal in situations where there is a sudden change of calibre, giving rise to increased friction from the passage of the contents — e.g., at the upper and lower ends of the oesophagus, at the pylorus, the ileo-caecal valve, either end of the sigmoid flexure, the lower part of the rectum, and the anus. (5) Moreover, if an early and thorough operation is undertaken, the growth can be completely eradicated from the system, whilst even if it recurs, it usually attacks the cicatrix or the neighbouring glands, indicating that the removal has been incomplete. The infective nature of cancer is still sub judice. Clinical evidence exists to indicate that cancer can be transmitted from one person to another, but it is somewhat scanty in amount. Thus, cancer of the cervix uteri has been known to be followed ■ by epithelioma of the penis in the husband. Again, it has been shown by Shattock that in certain houses (called by him ' cancer houses ') one set of indwellers after another has been attacked by this disease. Experimental research, as to the transmissibility of cancer from one individual to another, is necessarily unobtainable, although it has been proved that, in a person already suffering from cancer, a portion of the growth transplanted to a distant part of the body will grow, and lead to the formation of a similar tumour at the site of inoculation. Attempts have also been made to transmit the disease to animals, but with a very slight degree of success, even in cases where the point of inoculation has been previously irritated. Hence the view that cancer is due to infection depends rather on the analogy of the disease to other chronic infective dis- orders than on any well-ascertained facts. The relation of cancer to Psorospermiae has been much discussed of recent years, and by some authorities the disease is supposed to be due to these organisms. Their opinions, which are not generally accepted, are based on the following facts : (a) That in the majority of cancerous growths certain abnormal bodies resembling the coccidia of psorosperms have been demonstrated within the epithelial cells ; but even if these ' cancer bodies ' are of this nature, it has yet to be proved that they are causative, and not concurrent manifestations, whilst it is probable that they are merely foci of colloid degeneration, (b) In rabbits suffering from undoubted psorospermosis, outgrowths somewhat similar in nature to epithe- lioma have been detected in the biliary ducts and certain viscera, and these growths have even been produced by artificial inocula- tion with the organisms. Mention must be made here of Dr. Lack's interesting experiment in which he caused an extensive intraperitoneal development of cancer in a rabbit by scattering broadcast throughout the cavity the scrapings of an ovary which necessarily contained a vast number of living epithelial cells. His TUMOURS AND CYSTS 175 idea is that cancer is merely the outcome of the development of epithelium placed in unusually favourable nutritive conditions, e.g., in lymphatic spaces. Epithelioma {syn. : Squamous Epithelioma, Epithelial Cancer). — By this term is meant a cancerous tumour growing from skin or from those portions of the mucous membranes which are covered with squamous epithelium. The variety formerly known as columnar epithelioma is really of glandular origin, and will be described separately. Epithelioma is usually met with in middle-aged or elderly individuals, although occasion- ally it is seen in young adult life. Any portion of the skin may be the site of this tumour, as also the mucous membrane of the mouth, pharynx and oeso- phagus, and that lining the genito- urinary tract. It com- monly results from some long- continued irritation, as in the lip or tongue, whilst on the penis it is always associated with a long foreskin. Old scars, especially if they become ulcerated, are likely to be invaded, and the disease may supervene on intractable lupus. Clinically, epithelioma may be looked on as a malignant wart, which not only grows outwards from the surface, but also burrows deeply into adjacent tissues ; sooner or later ulcera- tion follows. Several character- istic forms are described : (a) It may occur as a nodular indurated mass, with hard everted edges and central ulceration, giving rise to a somewhat crateriform ulcer (Fig. 39). (b) The destruc- tive process may extend equally with the new formation, leading to the appearance of a depressed sore, with sharply-cut edges, closely resembling a rodent ulcer, (c) Occasionally the superficial outgrowth is excessive, and the destructive process limited, giving rise to a projecting cauliflower-like mass, which is soft and easily _ bleeds {malignant papilloma), (d) A chronic epithelioma is sometimes seen, in which the fibrous stroma contracts and com- \ A / A 1 7 Fig. 39. — Typical Epitheliomatous Ulcer, showing Heaped-up Mar- gins and Deep Central Crateri- form Excavation. (College of Surgeons' Museum.) I7 6 A MANUAL OF SURGERY presses the columns of epithelial cells; the surface is then indurated and wart-like, with but little ulceration, whilst the base is very hard, and the progress of the case much less rapid than in other forms. The disease, as a rule, early infects neighbouring lymphatic glands, which become the seat of a similar growth, and, if super- ficial, sooner or later involve the skin and give rise to charac- teristic ulceration. As the disease progresses, more distant groups of lymphatic glands are attacked ; it is unusual to find this form of cancer disseminated through the internal viscera. The glands sometimes become cystic, especially in the neck, and on cutting into them a thin, turbid fluid like sero-pus escapes, mixed, j* .■oaooo Fig. 40. — Section of Epithelioma. (Ziegler.) a, Epidermis ; b, corium ; c, subcutaneous areolar tissue ; d, sebaceous gland ; e, hair follicle ; /, cancerous ingrowths from the epidermis ; g, deeply-set cancerous cell groups ; h, proliferating fibrous tissue ; i (above), cell nesl or epidermic globe ; i (below), sweat gland. perhaps, with masses of epithelial debris ; from time to time similar material is discharged through the resulting sinuses. Ulceration into the main vessels of the neck may also follow, and cause death from haemorrhage ; otherwise the fatal event is due to cachexia and exhaustion. Microscopically, an epithelioma consists of club-shaped columns of epithelial cells, ramifying in the subcutaneous tissues, and interlacing freely with each other, so as to produce an irregular network, the meshes of which are occupied by a fibro-cellular growth (Fig. 40). The superficial cells in epithelioma are usually TUMOURS AND CYSTS 177 squamous in type, but in the deeper parts prickle cells are not unfrequently observed, whilst the processes are bounded by a tolerably definite layer of cuboidal epithelium, tending to become columnar. Within the processes, concentrically arranged collec- tions of squamous cells round one or more enlarged cells are often seen, known as 'epithelial nests ' (Fig. 40, i). The stroma in the neighbourhood of the advancing columns is always infiltrated with an abundant exudation of leucocytes. Rodent Ulcer is generally admitted to be a cancerous tumour of an epitheliomatous type, commencing probably in the sebaceous glands. It is usually met with in elderly patients, though occasionally observed in those under forty, and is seen with special frequency on the upper two-thirds of the face, the skin below the inner and outer canthi being the chief seats of election. It com- mences as a papule or flat-topped nodule in the skin, sur- rounded, perhaps, by an area of hyperemia. The infiltration ex- tends gradually in all directions, but the ulceration usually keeps pace with the new growth. The ulcer has a smooth but somewhat de- pressed surface, is perhaps covered with granulations, and bounded by a slightly-raised, indurated, rolled-over edge (Fig. 41). In the later stages one can often detect evidences of the new forma- tion beneath the skin beyond the edge. If kept aseptic, there is but little discharge, and imperfect attempts at cicatrization are often observed, the scar, however, readily breaking down; but when septic, the surface is covered with sloughs, and an abundant offensive discharge escapes. The condition is painless ; neigh- 12 -Rodent Ulcer. Photograph. 178 A MANUAL OF SURGERY bouring lymphatics are not enlarged, and the general health does not suffer, except in the later stages. The progress of the case is slow, but continuous, and although it spreads superficially rather than deeply, sooner or later underlying structures become in- volved, and nothing hinders the destructive process, even the bones of the skull being eroded, and the dura mater exposed. Microscopically, the growth is very similar to an epithelioma, consisting of interlacing columns of epithelial cells, interspersed with fibro-cellular tissue. The chief differences consist in the facts — (i.) that the constituent cells, although epithelial, are not epidermic in character, being smaller, more globular, never of the ' prickle-cell ' type, and rarely showing signs of keratinization ; hence, ' cell nests ' are uncommon, although they are sometimes observed, (ii.) The deep processes are not so distinctly columnar or club-shaped, spreading laterally beneath the unaffected skin rather than deeply ; their outline is also more clearly defined, and frequently angular on section, (iii.) There is less cell infiltration around the new formation. The Treatment of rodent ulcer consists in free excision when practicable, a margin of at least half an inch being allowed all round, and the defect made good by skin-grafting or by some plastic operation. Where such cannot be undertaken, the ulcer may be thoroughly scraped, and the surface treated with nitric acid, chloride of zinc paste, or some other caustic, the wound being allowed to heal by granulation. The X rays have also proved beneficial in these cases, the patient being submitted to their influence for about ten minutes daily. The surrounding parts are protected by plates of soft metal foil carefully fitted to them, and with a suitable hole in the centre exposing the sore. Sometimes a good deal of irritation results, but frequently the ulcer rapidly cleans up and commences to heal. Columnar Carcinoma. — This affection, which was formerly termed ' columnar epithelioma,' is in the majority of cases a true glandular cancer. It is met with most frequently in the alimentary canal, arising from any portion of it in which columnar epithelium occurs, and usually originating as an overgrowth of Lieberkiihn's follicles (Fig. 42). These form a projecting growth from the surface in the same way as a papilloma springs from the skin, but also penetrate deeply into the submucous and muscular coats. The deep processes retain an imperfect alveolar arrangement, and between them is found a certain amount of fibro-cellular stroma, upon the character of which the hardness of the tumour depends. In the firmer types the stroma is abundant, and fibro-cicatricial in quality, the growth of the tumour being slow ; in the softer and more rapidly-growing forms the stroma is less abundant, and more of a simple fibro-cellular nature. On section of a limited portion of the growth, it would often be impossible to distinguish it from a simple adenoma of Lieberkiihn's follicles ; but if a large section, TUMOURS AND CYSTS 179 including the whole thickness of the intestinal wall, is examined, the extension of the glandular tissue into and between the mus- cular fasciculi at once indicates the malignant nature of the case. Ulceration usually occurs, giving rise to a typical sore, bounded in the more chronic forms by indurated and everted edges. Neigh- bouring lymphatics are implicated, as in the case of all cancers, whilst later on the disease spreads to the viscera, and may be 02 i I 1 Fig. 42. — Section through Advancing Margin of Columnar Cancer of Stomach, x 25 (Ziegler.) a, Mucosa; b, submucosal c, muscularis; (/.serosa; e, neoplasm which, starting from the mucosa, has invaded the other layers. Small-celled infiltration has accompanied here and there the formation of the neoplastic tubules. generally disseminated. A similar type of growth occurs in the cervical portion of the uterus, and occasionally in the ducts of glands such as the liver and breast. It is also met with in the superior maxilla, originating in the tubular glands of the mucous membrane lining the antrum. Glandular or Acinous Cancer. — Glandular cancer may be looked on as a malignant form of adenoma, bearing the same relation to the latter as does an epithelioma to a benign papilloma. The epi- thelium of the glandular acini, from which it originates, is not retained by the basement membrane, but travels beyond it along 12 — 2 180 A MANUAL OF SURGERY the lymphatics into surrounding parts, which are transformed by a process already described into the tumour substance. The amount of stroma varies considerably, and according to whether it is abundant or small in quantity, the tumour is hard or soft in consistence, and slow or rapid in growth. To the former type the term Scirrhus is applied ; to the latter, Encephaloid. Scirrhus is met with most frequently in the breast, but also occurs in the prostate, pancreas, and pyloric end of the stomach. The clinical features of the disease as seen in the breast are described in Chapter XXXI. On naked-eye examination a scirrhous tumour appears as a hard nodular mass, the limits of which are imperfectly defined. When cut across, it creaks under the knife, and presents a yellowish-white surface, which rapidly becomes concave owing to the contraction of the fibrous stroma. It has often been compared to the section of an unripe pear or turnip, both on account of the grating sensation imparted to the knife, and from its appearance. On scraping the cut surface with the blade of a knife, a typical cancer juice is obtained, consisting of epithelial cells and debris. On microscopical examination, the tumour is found to consist of an abundant and well-marked stroma, the acini of which are filled with epithelial cells (Plate V., Fig. i). In the centre fatty degeneration is often present, small cysts being occasionally produced in this way. At the periphery the growth may be seen extending in all directions along the lymphatics, whilst a round- celled infiltration of the surrounding tissues is also evident. Where the stroma is very excessive, the cell elements, and, indeed, the whole tumour, may undergo atrophy, owing to the compression of the nutrient vessels, constituting the variety known as atvopliic scivrluis. Encephaloid, Medullary, or Acute Cancer, is the term given to a growth of a similar nature, in which the stroma is much less abundant than the cell elements. It constitutes a soft, rapidly growing tumour abundantly supplied with bloodvessels, and very early affecting neighbouring lymphatic glands. The skin over such a tumour is stretched, and dilated blue veins can be seen through it. Ulceration occurs early, and from this surface a foul, bleeding, fungating mass sprouts up, formerly known as a ' fungus haematodes.' Encephaloid cancer is met with in the breast, testis, kidney, and a few other glandular organs. On section it is found to be composed of a soft whitish mass, somewhat resembling brain substance. It is usually very vascular, perhaps pulsating, and haemorrhagic extravasation into its tissues is not uncommon. An abundant juice is obtained on scraping. Under the microscope large groups of spheroidal epithelial cells are seen, held together by a scanty stroma. Colloid Cancer results from a degeneration of the epithelial • ■* -, *••*"« *.*-« ^ r > W H < ■*-»•. «p - A <*i£i& < tki *** K s 2 < . s < c C H - < _ u 5C TUMOURS AND CYSTS cells of a glandular or columnar cancer. Its most frequent site is within the abdominal cavity, in connection with cancers arising from the stomach, intestine, or omentum. To the naked eye colloid cancer presents an alveolar structure, the spaces being filled Avith translucent gelatinous material of varying density. Microscopically, the epithelial cells are rarely distinguishable, being replaced by a structureless colloid sub- stance. Towards the growing margin, however, the cells may be seen in process of degeneration, globules of the material forming within them and pressing the nucleus to one side. The Treatment of Cancer consists in the removal of the tumour by operation, together with a wide margin of healthy tissue around it, or, in some cases, of the whole organ affected, as well as the lymphatic area concerned, and, if practicable, in one mass, so as not to cut across the lymphatic vessels passing from the growth to the glands. If such is conducted in a thorough manner and at a sufficiently early date, a good result may be anticipated ; but, owing to the tendency of all cancers to spread along lymphatics, its eradication is usually a matter of the greatest difficulty. Recurrence is therefore very liable to ensue. In cases where removal of the disease by the knife is im- practicable, owing to its extent, it may sometimes be possible to remove a portion of the disease, the remainder being dealt with by caustics. Of these the most satisfactory is chloride of zinc, which is usually applied as a paste, a little opium being added to allay pain. In other instances it has been proposed to starve the growth by tying the chief nutrient artery, and to diminish pain by division of sensory nerves ; such can, however, only give the most temporary relief. Of recent years other methods have been suggested for the treatment of inoperable malignant disease — e.g., the interstitial injection of pyoktanin or methyl violet, or of various bacterial products, such as Coley's fluid (p. 160). The evidence at present forthcoming suggests that the practical value of these proceedings is very small in the case of the cancers. Superficial cancers, such as epithelioma labii, can be cured by exposure to the X-rays, but it is doubtful whether deeply-seated foci can be influenced in this way. In hopeless cases, all that can be done is to keep any ulcerated surface free from irritation, and if possible aseptic, whilst the general health is maintained by suitable diet and drugs, and excessive pain is kept in check by the administration of opium or morphia. Cysts. By a cyst is usually meant a more or less rounded cavity, with a distinct lining membrane, distended with some fluid or semi- 182 A MANUAL OF SURGERY solid material. The term is used very loosely, being applied to a variety of manifestations which it is difficult to classify, owing to the fact that conditions which are pathologically similar in origin are sometimes termed cysts in one part of the body, and not so in another. For practical purposes, however, they may be grouped as follows : I. Cysts of embryonic origin, or arising in connection with embryonic remains. II. Cysts arising from the distension of pre-existing spaces (dis- tension cysts). III. Cysts of new formation. IV. Cysts of degeneration. I. Cysts of Embryonic Origin, or arising in connection with Embryonic Remains. i. The most important cysts to be considered under this head- ing are those known as Dermoids. These are characterized by the existence in abnormal situations of cavities lined with epithelium, from which may be developed any form of cutaneous appendage — e.g., hairs, nails, teeth, etc. — whilst the space is usually occupied by sebaceous or mucous contents. The struc- ture of the lining wall is very similar in nature to l||#^v! V skin or mucous membrane, % * ;1 ^ • P \^ 3 consisting of stratified epi- fflMi*^^^\V. .. iasaia*, » thelium, from which a con- siderable growth of sebaceous glands and hair follicles often takes place. Several varieties of dermoids are described : (a) Sequestration Dermoids are cysts arising from the incomplete disappearance of surface epithelium in situa- tions where, during embryonic life, fleshy segments coalesce. Thus, in almost any part of the middle line of the body such tumours may develop, owing to the fact that there is here a union of two lateral segments. Similarly, they are not uncommon about the face and neck, occurring along the lines of the facial and branchial clefts. Perhaps the most common position for them in this region is the upper portion of the Fig. 43. — Dermoid Cyst, growing at the Outer Angle of the Orbit. (Bland Sutton.) TUMOURS AND CYSTS 1S3 orbito-nasal cleft, behind and to the outer side of the eye Fig. 43). It is not unusual to find the skull defective beneath them, and a pedicle extending from the deep side, connecting them with the dura mater. Sequestration dermoids appear as rounded, definitely limited tumours, over which the skin glides freely, but are usually somewhat adherent to the deeper parts. They are firm and elastic to the touch, and filled with sebaceous material, containing fatty debris, flattened epithelial cells, perhaps hairs, and occasionally teeth. This form of dermoid may be removed without difficulty, but in those occurring about the scalp, with the bone hollowed out beneath them, it is perhaps advisable to delay operation till adult life, unless the tumours are rapidly increasing in size. The reason for this is that the bone gradually grows up around the pedicle, and thus closes the communication with the cranial cavity. In some cases it may be difficult to remove the whole of the lining membrane by dissection, and under these circumstances the portion left behind should be destroyed with cautery or caustics : otherwise, recurrence is almost certain to follow. (b) Dermoids may also arise in connection with embryonic canals and passages, and have then been called Tubulo-Dermoids. These are chiefly met with in connection with the thyro-glossal duct (Chapter XXIX.) and the post-anal gut (Chapter XXII.). (c) Ovarian Dermoids are usually unilocular, and of large size. They are lined with skin, from which an abundant development of cutaneous appendages is sometimes observed. Thus, the cavity may be more or less filled with hair, whilst large masses of teeth set in bony alveoli are also seen in this situation, and even nipples and mammae. 2. Cysts occasionally arise in connection with the formation of the teeth ; such have been already alluded to under the terms follicular and epithelial odontomes (p. 171), the former being also known as dentigerous cysts, the latter as fibro-cystic disease of the jaw. 3. Various cysts develop in connection with the remains of the Wolffian body, as also from its tubules and duct. It must be remembered that this body arises in the posterior abdominal wall near to the origin of the kidney and testis, and that part of it enters into the formation of the latter ; hence one is not surprised to find that its remains are closely associated with that organ in the scrotum. In the male (Fig. 44) the Wolffian body atrophies almost com- pletely, being represented by a few blind tubules, situated close to the epididymis, and known as the paradidymis, or organ of Giraldes. Fibro-cystic disease of the testis (adenoma testis) is said to arise from this structure. The majority of the ducts of the Wolffian body form the vasa efferentia testis ; a few of the upper ones, however, contract no attachment to the gland, and their free ends (known as Kobelt's tubes) may become dilated, 1 84 A MANUAL OF SURGERY and form small cysts, situated close to the hydatid of Morgagni, which structure represents the remains of the Miillerian body and duct. It is possible that an encysted hydrocele of the epididymis sometimes arises from one of these unobliterated tubules. The main duct of the Wolffian body forms the lower portions of the epididymis and vas deferens. In the female (Fig. 45) the remains of the Wolffian body are sometimes met with as a series of closed tubes in the neighbour- hood of the ovary (paroophoron). Cysts may arise in connection with this structure, and are chiefly characterized by their inner walls being the seat of proliferating papillomata. The Wolffian tubules can almost always be recognised in the broad ligament, Paradidymis or A i'jJ~$£ Mesonephros. Kobeh's tubes. Fig. 44. -Diagram of Adult Testicle, to show Relation of Mesonephros and its Ducts. (Bland Sutton.) constituting the parovarium, or organ of Rosenmuller. Parovarian Cysts formed from the distension of this structure are usually unilocular, and filled with a clear limpid serous fluid ; they have no definite pedicle, and strip up the layers of the broad ligament. Some of the terminal tubes may be converted into small cysts which project from the fimbriated ends of the Fallopian tube, and are known as cysts of Kobelt's tubes. The main Wolffian duct generally atrophies, but occasionally runs down between the layers of the broad ligament close to the uterus, to open in the vagina near the urethral orifice, being then known as Gartner's duct. Cysts may occasionally arise in connection with this structure, projecting into the lateral fornix of the vagina. 4. The processus vaginalis, or funicular process, is the term applied to the protrusion of peritoneum which precedes the testis TUMOURS AND CYSTS 185 to form the tunica vaginalis, and which in the female accompanies the round ligament (canal of Nuck). Normally it becomes obliterated, but sometimes portions of it remain patent, and are distended with a clear straw-coloured serous fluid, constituting in the male an encysted hydrocele of the cord, and in the female a hydrocele of the round ligament. II. Cysts due to the Distension of Pre-existing Spaces. (a) Exudation Cysts arise from the distension of cavities which are unprovided with excretory ducts, and are frequently of an inflammatory nature. Such spaces may be lined with epithelium or endothelium. As illustrations of epithelial cysts may be Fig. 45 — Diagram to represent the Cyst Regions of the Ovary. (Bland Sutton.) A, Oophoron, or ovarian tissue; B, paroophoron, or tissue of the hilus ; C, parovarium ; K, Kobelt's tubes ; G, Gartner's duct (= main Wolffian duct). mentioned those which arise in connection with the thyroid body, as also conditions due to the distension of the central canal of the nervous system (syringo-myelocele), and those forms of ovarian cysts which arise from distension of Graafian follicles. Exudation cysts lined by a serous or endothelial wall are much more numerous. Enlargements of bursas, hydroceles of the tunica vaginalis, funicular process, or canal of Nuck, and some forms of ganglia, are of this nature. Diverticula or hernial pro- trusions of the synovial membrane of joints also occur, and are known as Baker's cysts. A Serous Cyst is supposed to arise from the distension of lymph spaces, giving rise to uni- or multi-locular cavities, lined with endothelium, and containing a limpid straw-coloured fluid. They 186 A MANUAL OF SURGERY are seen most commonly in the neck, axilla, or breast, and in the latter structure may be surrounded by a dense, sclerosed, fibrous tissue. It is usually possible to dissect them out, but occasionally one has to rely on draining them or on stuffing them, so as to insure healing by granulation. Adventitious bursae are formed in a precisely similar manner. (b) When a collection of blood forms in a pre-existing cavity, a so-called Cyst of Extravasation is produced. Such is met with in the pelvis or tunica vaginalis (hematocele), and also occasionally on the surface of the brain, constituting what is known as an arachnoid cyst. (c) Retention Cysts always arise from obstruction to the escape of some natural secretion from a gland duct or tubule. The cavity thus formed is lined with epithelium, whilst, owing to the irritation produced by the tension, a fibro-cicatricial wall of variable thickness is developed outside. There is often a con- siderable formation of intracystic growths, especially in the breast, whilst the contents generally consist of the inspissated secretion, perhaps mixed with blood. Retention cysts may develop in connection with any glandular tissue. The majority are described under the appropriate headings, viz., Mammary cysts, Renal cysts, Pancreatic cyst, etc. III. Cysts of New Formation are such as occur apart from any embryonic condition or pre-existing cavity. The following varieties may be described : (a) An Implantation Cyst is one which arises from the accidental intrusion into the subcutaneous or submucous tissues of epithelial cells which retain their vitality, and are enabled to develop a cyst very similar in nature to a dermoid ; in fact, it may be looked on as an Acquired or Traumatic Dermoid. Such an occurrence is usually brought about as the result of an injury, especially from punctured wounds ; thus, cysts of this nature have been met with in the fingers or palm of the hand as a consequence of the penetration of some sharp instrument, whilst they are also occa- sionally seen in the anterior chamber of the eye, following an iridectomy. They are, moreover, observed in the axillae of cattle, as a result of goading them with a sharp implement. The clinical signs and treatment are similar to those of a dermoid cyst. (b) Cysts sometimes form around foreign bodies, which thus become encapsuled. They are lined by granulation tissue or endothelium, surrounded by a variable amount of fibro-cicatricial tissue. (c) Blood Cysts are sometimes of doubtful origin. Some of them certainly arise from extravasation of blood, and in such cases coagulated blood, or a thin serous fluid, is found within, the cavity being perhaps lined with laminated fibrin. In many cases a so- called blood cyst is really a soft sarcoma, into which haemorrhage TUMOURS AND CYSTS .87 has occurred ; but in addition to these, a few instances are on record in which a thin-walled cavity existed, occupied by blood, and readily refilling after it had been tapped. Such conditions have been most frequently observed in the neck (see Chapter XXIX.). (d) Parasitic Cysts are produced by the irritation caused by the growth within the tissues of certain living organisms. Thus, in the disease known as trichinosis, derived from eating unsound pork, the Trichina spiralis, a small round worm, develops in large numbers in the voluntary muscles, and becomes surrounded by a capsule which is subsequently calcified. The most important of these parasitic cysts is that caused by the development within the body of the scolex stage of the Tania echino- coccus, giving rise to what are known as Hydatid Cysts. This disease is much more common in Australia than in this country. The Tceuia ecliinococcus (Fig. 46) is a minute tapeworm, less than half an inch in length, which inhabits the intestinal canal of dogs ; it consists of four segments, the posterior one being larger than the rest of the body, and containing the genital organs. When mature, this last segment be- comes filled with ova, which are discharged, and these find their way into the human stomach by the media of water or uncooked vegetables, such as watercress, which have been contaminated with the dog's excreta. The pro- cess of digestion sets the embryo free, and by means of a crown of little hooks which it pos- sesses, as well as four suckers, it is enabled to bore its way through the walls of the stomach, and thence travels by the bloodvessels to the liver or some other part of the body. As a result of the irritation caused by its presence, a sac forms which originally consists of three layers ; externally, a fibro-cicatricial layer, then an inter- mediate lamellated layer of chitinous material (true ectocyst), and finally the cyst is lined by a protoplasmic germinal layer (endocyst), from which may be developed solitary taenia heads or scolices, also provided with four suckers and a circlet of hooks, whilst some- times groups of them, known as brood-capsules, may arise in the same way (Fig. 48). Daughter-cysts are not unfrequently formed from the scolices, and they in their turn may pass through the same changes, although as a rule they are barren. Occasionally even the main cyst may be sterile (acephalocyst), and in such cases &-, ViX^ Fig. 46. — T.3;nia Echinococcus. X ABOUT 20. A MANUAL OF SURGERY the walls become very definitely laminated. The fluid contained in the cyst varies much in amount, but is always of low specific Fig. 47. — Hydatid Cyst (Diagrammatic) showing Daughter-Cysts and Brood-Capsules growing from the Walls. (After Bland Sutton.) Fig. 48.— Diagrammatic Section of Wall of Cyst. a, Fibro-cellular capsule, here somewhat exaggerated ; b, lamellated chitinous layer, or ectocyst ; c, brood-capsules developing from the protoplasmic layer, or endocyst ; d, scolex, or separate head, enlarged. gravity, not more than 1007 ; it is colourless, but slightly opales- cent, limpid, and contains but a trace of albumen, although a considerable amount of chloride of sodium is present. On TUMOURS AND CYSTS examining the fluid microscopically, the characteristic hooklets are observed. The organs usually affected by hydatid disease are the liver, kidneys, and brain, but any part of the body may be attacked. Occasionally in the liver, and usually in bone, multiple cysts develop quite distinct from each other, and with no general cyst- wall (exogenous multiplication). This can only occur when the ectocyst is thin, allowing the scolices, which always have a retractile neck, to push through and ' swarm off ' into surrounding tissues. Hydatid cysts give rise to no special symptoms, except those caused by their size and situation, and they are likely to go on growing until operative treatment becomes imperative on account of some complication, or from the size of the mass. At any time the cyst may rupture, either spontaneously or as the result of some injury ; if into a serous cavity, such as the peritoneal or pleural, this becomes infected, and an abundant development of scolices and cysts ensues, giving rise to considerable localized inflam- matory reaction ; moreover, the escape of the cyst fluid may cause serious toxaemia, or, at any rate, urticaria, owing to the presence therein of some toxic substance. Occasionally the organism dies spontaneously, and then the cyst shrivels up, and the laminated walls and daughter-cysts form a firm leathery mass, perhaps infiltrated with lime salts and of the consistency of wet mortar ; a thick fibro-cicatricial capsule encloses the whole. At other times suppuration takes place within the cyst and an abscess results. If acute, it bursts either exter- nally, or may open into some serous cavity or hollow viscus ; in the last case, the cyst may evacuate itself, and a spontaneous cure result. Sometimes the abscess becomes chronic and encapsuled, and may then remain quiescent for years. For the diagnosis and treatment of hydatid cyst of the liver, see Chapter XXXII.). In other regions, if the tumour cannot be removed by dissection, reliance must be placed on drainage, where the situation of the growth renders this practicable, or aspiration, since it is usually found that removal of the fluid contents causes death of the organism, probably by altering the intra-cystic tension. IV. Cysts of Degeneration arise in connection with tumours, especially those where the blood-supply is not very abundant. Thus, mucoid degeneration is not uncommon in fibromata, fibro- myomata, chondromata, and even in the harder forms of cancer. Occasionally cysts form in the sarcomata from this cause, but more frequently as a result of haemorrhage. CHAPTER VIII. WOUNDS. A wound has been defined as the forcible solution of continuity of any of the tissues of the body ; but the term is more commonly limited to injuries of the soft parts, involving the skin or mucous membranes. Lesions in which the skin does not participate, and in which the deeper structures, such as bones, ligaments, etc., are not involved, are spoken of as contusions. A Contusion is any subcutaneous wound or injury due to the agency of external violence, causing laceration of the cellular tissue, without necessarily involving such deeper structures as muscles, tendons, nerves or bones. The signs are usually very obvious, viz., pain, bruising, or discoloration of the part, and swelling. These are readily explained by the injury inflicted on the subcutaneous tissues, which in the worst cases may be entirely disorganized and separated from the skin. The amount of bruising varies with the part injured and the severity of the lesion ; thus, in the eyelids, scrotum, and vulva, where the tissues are lax, the ecchymosis will be very extensive and of a black colour ; on the scalp there is, on the other hand, but little swelling, if the injury does not include bleeding beneath the aponeurosis of the occipito- frontalis. Again, the condition of the patient's general health influences the amount of blood effused ; in a strong man in good training, but little bruising is seen, whilst in those of a languid temperament and relaxed tissues, a slight injury often produces a very conspicuous ecchymosis. Blebs and bullae may form over the injured spot in bad cases. The changes that occur in a bruise are well known, the colour passing from a blackish-purple through various shades of brown and green to a yellow, which gradually fades and disappears ; this is due to the disintegration of the red corpuscles, and staining of the tissues by the haemoglobin thus set free, or by the products formed during its removal. When haemorrhage has taken place into the deeper parts or under dense fasciae, it is often some days before the bruise ' comes out,' and this may occur at some distant spot, e.g., in the eyelids after a blow on the scalp, whilst after a fracture of the neck of the WOUNDS 191 humerus the blood may travel along the muscular and fascial planes, and the bruise first appear about the elbow. In a bruise or ecchymosis, the tissues are, as a rule, merely infiltrated with blood, but occasionally the extravasation is more localized, collecting in a cavity formed by the laceration of the tissues, and remaining as a fluid swelling, or Haematoma. If somewhat resembles an abscess to the touch, but differs from it in its history, having supervened immediately after an injury, and having appeared without any heat or other sign of inflammation ; moreover, though at first fluid and soft, it soon becomes harder, whereas an abscess is preceded by a stage of brawny infiltration, and the softening occurs later. The subsequent history of a haematoma varies somewhat according to circumstances, (a) A deposit of fibrin may be formed peripherally, leaving for a time a fluid centre, which gradually disappears, and the whole is finally absorbed. This is well exemplified in a sub-pericranial cephal- hematoma, where the contrast between the fibrinous deposit with- out and the fluid centre is sometimes so accentuated as to give the impression of a depressed fracture, (b) The fluid portion of the blood may be absorbed almost entirely, and the solid fibrinous residuum may become organized into a firm fibroid tumour which persists indefinitely ; the mass is more or less laminated, and not unfrequently pigmented, (c) The fibrin may be entirely absorbed, and a slightly pigmented fibrous capsule formed containing serous fluid, and constituting a definite cyst ; such is best seen in con- nection with the cerebral tunics (arachnoid cyst), (d) Suppuration may ensue owing to infection from within the body, or from an invasion of organisms through abraded skin. In forming an opinion as to the gravity of a subcutaneous injury, one must be guided by the part injured, the extent of tissue involved, the amount of blood extravasated, and the age and vitality of the individual. In the less severe cases, though there may be a good deal of bruising, recovery will ensue, but under less favourable conditions sloughing and death of the injured tissues may result. The Treatment of a bruise usually consists in the application of cold or evaporating lotions and pressure in order to check the bleeding, but such must be used with care in old weakly individuals or where much laceration of the tissues has taken place, for fear of the injured parts dying. The skin should never be incised except under special circumstances, such as the rupture of a large artery, or when some definite advantage is to be gained by dealing at once with the injured structures; for though under careful anti- sepsis the dread of opening recent collections of blood no longer exists, yet it should not be lightly undertaken. At the same time, when a tense and painful haematoma exists, as under the fascia lata of the thigh, recovery can be hastened and pain relieved by an aseptic puncture, followed by careful compression. In general 192 A MANUAL OF SURGERY bruising of the body from a fall or extensive injury, pain can often be relieved by applying fomentations or by a hot bath. There is generally a certain amount of fever and constitutional disturbance for a few days, and these are dealt with by purgatives and a suit- able limitation of diet. Open Wounds. An open wound may be defined as a solution of continuity of any superficial part of the body, including skin or mucous mem- brane. Various kinds of wounds are described, such as the incised, lacerated, contused, punctured, poisoned, and gunshot ; but, of course, the most important distinction to draw is between the infected and the non-infected. 1. Incised Wounds. — An incised wound is one made by any sharp cutting instrument, but occasionally a wound not produced in this manner may be characterized by similar appearances ; e.g., the skin of the knee or elbow may be cleanly split open from falling on it with the limb flexed, and occasionally a policeman's truncheon will lay open the scalp almost as evenly as if a knife had been employed. The special features of an incised wound are as follows : i. The haemorrhage is free, from the fact that the vessels are cleanly divided. The amount necessarily depends on the size of the vessels involved, and the vascularity of the part ; its continu- ance, upon the density of the structures allowing or not of con- traction and retraction of the severed ends. 2. Separation of the lips of the wound also occurs, the amount depending upon the elasticity and character of the parts involved. 3. Bruising of the margins of the incision is absent, so that under ordinary circumstances rapid healing (by first intention) should obtain. The surfaces, to begin with, are lined by a microscopic layer of damaged tissue, some of which may be actually dead ; but if suitable precautions are taken, this is absorbed, and in no way interferes with satisfactory union. Treatment of Incised Wounds. — Seven essentials must be attended to if healing by first intention is to be obtained, viz. : (i.) The Arrest of all Bleeding. —If there is general oozing, exposure to the air is often quite sufficient ; or sometimes it may be supplemented by pressure for a few minutes with an aseptic sponge. Arteries and veins will need a ligature, but if situated close to the skin, they may often be secured by passing under the bleeding spot the needle used for the suture. (ii.) Sterilization of the Wound and its Surroundings. — When made by the surgeon through skin which has been previously purified, and if efficient precautions as to hands, instruments, etc., have been taken, there is no need to flush out the wound with any antiseptic. All such substances are more or less irritating, and when introduced into a fresh wound are likely to increase WOUNDS 193 exudation and render drainage necessary. In such cases it will suffice to cleanse the parts with sterilized salt solution. In casualty work, however, a wound, though cleanly cut, is made through dirty skin, and portions of clothing, dirt, and splinters of wood or glass may be carried in. Under these circumstances the wound and its surroundings must be thoroughly purified, according to the rules given on p. 18, and a free use of 1 in 20 carbolic lotion, or even of Lister's ' strong mixture ' (5 per cent, of carbolic acid with 'i per cent, of corrosive sub- limate), is advisable, whilst foreign bodies are removed. (iii.) The coaptation of the opposed surfaces by means of sutures may now be undertaken. Many substances have been, and are, employed for this purpose, but amongst the best are fine silver wire, silk, horsehair, silkworm gut and catgut. In casualty work, and for parts of the body where but little scar is subsequently desirable, as in the face, horsehair and silkworm gut, being non- absorbent, are perhaps the best materials to employ ; but in ordinary operative work, which will be more certainly aseptic, and where the after-treatment is more efficient, fine catgut or silk may be used. There are three chief varieties of sutures, viz., the buried, the deep, and the superficial. Buried sutures are now largely employed, since a foreign body may be safely inserted into the tissues, if both it and the wound are aseptic. Catgut and silk are the agents made use of, and nerves, tendons, muscles or fasciae are the structures mainly dealt with. In deep wounds it is always most desirable to effect union in this way of all the divided tissues (that is, to build the part up again), and not merely to unite the skin over them. Deep stitches, or sutures of relaxation, are required in cases where there is difficulty in bringing the edges of the wound together, in order to transfer the tension from the healing margin to tissues further away, the edges being thereby relaxed. For this purpose thick silver wire may be employed, inserted ior i| inches from the margins, and tied directly, or lead buttons may be interposed next to the skin, and the ends of the wire fastened round the projecting edges, thus diffusing the pressure over a greater space. They are generally removed at the end of two or three days. Superficial stitches, or sutures of coaptation, must be so inserted as to bring the edges of the wound into contact without undue pressure, and without any folding in of the skin. Various methods are employed, viz.: I. The interrupted suture (Fig. 49, A), in which each stitch is separately finished off, the knot lying well to one side of the incision. This is generally utilized for wounds which are of irregular shape or in which there is tension. 2. The glover s stitch (Fig. 49, B) is a continuous one, in which the thread is carried on from point to point, and only fastened at the ends ; it is not to be recommended. 3. The blanket or buttonhole stitch (Fig. 49, C) is the form of continuous suture which should be J 3 £94 A MANUAL OF SURGERY employed for extensive wounds or incisions. In it the needle, after traversing the lips of the wound, is carried under the slack of the thread, so that the loop of each stitch, as it is tightened, is maintained at right angles to the edge of the wound, whilst the intermediate portion lies parallel to it. To fasten it off, the needle is passed in the opposite direction through the edges of the incision, with the free end long enough to prevent it coming through, and so enable it to be tied to the double portion carried through by the needle. 4. The quilled suture is not often employed. Fig. 49. — Various Forms of Suture. A, interrupted suture ; B, continuous suture ; C, blanket stitch. At the lower end the needle has just been passed, and the way in which it catches up the loop :*s indicated. At the upper end the method of finishing off (originally suggested by the late Mr. Maunsell) is shown : viz., the needle is passed in the opposite direction to all the other stitches, the free end being left long, so as to enable it to be tied into a knot with the double thread which the needle has carried through. It consists in tying the stitches round a quill or portion of catheter on either side of the wound, so that the deep surfaces may be maintained in apposition, whilst the superficial portions are left clear for additional sutures. The only conditions under which it is now used are in the operations for ruptured perineum, or for extensive perineal or urethral fistulae. 5. The twisted or jigure-of-8 suture is still occasionally made use of for harelip or scalp wounds, WOUNDS 195 but has many disadvantages. A pin or needle is passed through the sides of the wound, which are brought into apposition with the fingers, and maintained by twisting silk around either end of the needle in a figure-of-8 fashion. Plasters are sometimes used instead of sutures, but the wounds must be very small and insignificant which only require such treatment. A fine aseptic suture is in most cases preferable. (iv.) Drainage must, if necessary, be provided, in order to guard against the irritation and tension caused by retained blood or exudations. In wounds where there is doubt as to the com- pleteness of the haemostasis, or where there has been much tearing or laceration of the tissues, it is wise to insert a tube for 24 or 48 hours, in order to allow effused blood to escape ; but if the wound is dry and aseptic, and efficient pressure can be exerted by the dressings, it may be dispensed with. When drainage is required, the indiarubber tube introduced by Chassaignac answers well ; the end should be cut flush with the surface, and stitched to the edges of the wound so as to prevent it slipping in or out. Decalcified bone tubes have been substituted, but w T ith no distinct advantage. For small wounds, a strand of horsehair or a strip of gauze or protective will usually suffice. (v.) All fresh sources of irritation and infection of the wound must be excluded by some form of antiseptic or aseptic dressing. (vi.) Rest to the injured part must be secured by such an arrangement of splints, slings, or bandages as may be necessary. (vii.) The general health of the patient is a most important item to attend to. In an operation case the bowels should, if possible, be previously opened, and the patient's diet carefully regulated ; in casualty work a good purge should be administered as soon as convenient, and the food and drink limited. Under ordinary circumstances an aseptic incised wound heals in about five to seven days, but the actual time when it is safe to remove the stitches varies with the age and vigour of the indi- vidual, the part of the body, and the amount of tension required to draw the lips of the wound together. In ordinary aseptic operation wounds one usually removes the stitches on the eighth day ; but in the face it is often possible and advisable to take them out earlier, partly because the healing process is quickly accomplished in such a vascular region, partly in order to mini- mize the amount of scarring. Many conditions may arise to prevent the healing of an incised wound by first intention, and they may be epitomized as essenti- ally the reverse of the seven conditions mentioned above — viz., (i.) Non-arrest of the bleeding, causing separation of the lips or deeper portions of the wound ; (ii.) the presence of impure foreign bodies or other septic material ; (iii.) the edges not being brought into contact ; (iv.) imperfect drainage, leading to tension on the stitches ; (v.) subsequent infection of the wound owing to a 196 A MANUAL OF SURGERY faulty dressing, etc. ; (vi.) lack of rest to the part ; and (vii.) constitutional conditions, such as deficient general vitality from disease or other causes, resulting in want of action in the wound. The most common cause of non-union is without question septic contamination of the part. The essential nature of this process and its dependence, either on pathogenic or non-pathogenic germs, have been already explained (p. 5). The inflammatory trouble is acute or subacute, according to the virulence of the organisms and the resisting powers of the patient ; it may mani- fest itself merely as a suppurative process within the wound, or as an active cellulitis spreading into the adjacent tissues. It may commence deeply around a buried stitch or superficially. In the latter case the lips of the wound look red and puffy, the tissues often swell up between the stitches, which look as if they were too tight ; the patient complains of pain, usually of a throbbing nature, and there is some rise of temperature, and in bad cases even a rigor. In the milder forms, the trouble is limited to the immediate neighbourhood of the wound ; but if neglected, or in an unhealthy subject, or if due to virulent germs, the phenomena of an acute cellulitis may supervene, whilst the general condition may constitute an attack of septic traumatic fever, or may even run over into a true septicaemia. When the process starts quietly in the deeper parts of the wound, nothing may be obvious on the surface for a few days, except perhaps some fulness and tenderness on pressure. It will usually be found, however, that the temperature is slightly raised, and that some tensive pain is present. Sooner or later an abscess develops and comes to the surface. The local treatment of a septic wound consists essentially in the relief of all tension, the removal, as far as possible, of all putrescible material, and the application of warmth and moisture to the part, if superficial, to encourage the local reparative activity of the tissues. Stitches must be immediately removed, and the wound widely opened up, care being taken to ascertain whether or not the pus has burrowed, as if so it must be followed up. Sloughs may be cut or scraped away under an anaesthetic, and all putrid or putrescible material removed, if possible. The parts are then thoroughly washed out with some antiseptic solution, and may advisably be treated with peroxide of hydrogen or liquefied carbolic acid ; but it must not be forgotten that where the organisms have invaded the living tissues, no antiseptic is likely to reach them, at any rate, not without also destroying the tissues. The wound is then lightly, though thoroughly, packed with gauze soaked in an emulsion of iodoform and glycerine, and if there is a deep cavity, it may be desirable to introduce a drainage-tube, especially when suppuration is present, since pus does not easily escape along a gauze drainage wick. It is not WOUNDS 197 advisable to pack the gauze into the wound too tightly, as there- by the escape of secretions may be prevented, and pain and tension may ensue, whilst possibly bacteria may be driven into the tissues and give rise to further trouble in the nature of erysipelas or cellulitis. Warm, moist dressings, such as an anti- septic fomentation, are then applied, or it may be desirable either to immerse the limb in a hot antiseptic bath for an hour or two daily, or to keep it in for some days. At the same time the bowels must be freely opened, and the general health of the patient care- fully watched. The more serious cases are dealt with in the same manner as an attack of cellulitis (q.v. on p. 91). When the union of the wound is interfered, with owing to an accumulation of blood or serum in the deeper parts whilst the integument is healing, it often suffices to partially open the incision, squeeze or press out the fluid, and insert a small tube or gauze drain. II. Lacerated or Contused Wounds. — Such injuries are caused by blunt instruments, by machinery, missiles, the wheels of a vehicle, etc. They are characterized by the following signs : 1. The Haemorrhage is, as a rule, but slight, since the vessels are torn across irregularly, and not cut cleanly ; the middle and inner coats, w r hich give way first, are curled up within the con- torted outer coat, forming a barrier sufficient to prevent loss of blood. The vessels, being elastic, may be pulled out of their sheaths, and are sometimes seen pulsating upon the surface. 2. The Lips gape less than in an incised wound, and are irregular, torn, and bruised. More or less extensive portions of dead tissue have to be disposed of before repair can take place, and hence this form of wound usually heals by granulation. When a limb is torn completely off, the tendons are often left long, and the muscular bellies project from their fascial sheaths, as flabby con- gested masses, since the skin gives way at a higher point than the subjacent structures. The Progress of the case depends largely upon the question whether the wound is or is not aseptic. In an Aseptic lacerated wound it may be possible to bring the edges together by suture or otherwise, and, even though they are a little bruised, healing by a slightly delayed first intention is possible, if drainage is provided. If the wound remains open, the dead tissue is absorbed or separated, and an aseptic granulating surface results. There may be some simple traumatic fever for a day or two, but it is of little consequence. If the wound is Septic, however, inflammatory phenomena supervene, resulting finally in a granulating surface. Three stages may be described in the course of the case, viz. : (a) The stage of injury, resulting in shock. (b) The stage of inflammation and sloughing, associated with septic traumatic fever. 198 A MANUAL OF SURGERY (c) The stage of repair by granulation, or prolonged suppura- tion, with exhaustion and hectic fever in the worst cases. The inflammatory period lasts a week, ten days, or more, accord- ing to circumstances, and during this period the patient is liable to various forms of septic trouble, including secondary haemor- rhage, toxaemia, pyaemia, and traumatic gangrene. The Treatment of contused and lacerated wounds varies with- their character, and no absolute rule of practice can be laid down to suit all cases. The following routine is that usually adopted : (a) Immediate Treatment. — The great desideratum in all these cases is to render the wound aseptic. To accomplish this in severe injuries, it is wise to anaesthetize the patient, and then, after shaving the skin, if necessary, the wound and its surround- ings are scrubbed with soap and carbolic lotion (i in 20) by means of a sterilized nail-brush. Foreign bodies are removed, and dead or doubtful tissues cut away, if unimportant, whilst bleeding vessels are secured by ligature. Ample provision must be made for drainage, since the carbolic irrigation of itself causes much exudation ; occasionally it is desirable to make a counter-opening for this purpose. The wound is closed by sutures, but it is advisable to remove ragged and torn fragments of skin with the scissors or knife, if there is sufficient tissue around ; an antiseptic dressing of the usual type is then applied. If, however, the skin is scanty and asepsis not assured, it is better to leave the wound open, or, at any rate, only to partially close it, packing it care- fully with gauze impregnated with iodoform. (b) Subsequent Treatment depends on whether or not the measures adopted to obtain asepsis have been successful. If the wound remains free from infection, nothing special is called for beyond careful dressing. If it becomes septic, and the surface is covered with sloughs, these must he removed by natural or artificial means before healing can occur ; the use of antiseptic poultices will considerably expedite matters, but it must be remembered that secondary haemorrhage may occur when the dead tissues are finally detached. During this period inflam- matory fever continues, and the patient's general health must be closely watched. When once a clean granulating surface is obtained, it is treated in the same way as any healing wound, skin-grafting possibly being needed in the more extensive cases. The question of Amputation will sometimes be raised in dealing with the graver forms of lacerated wounds, although many limbs are now saved which would inevitably in former days have been sacrificed. Hard-and-fast rules cannot be laid down as to when to amputate and when not to do so ; each case must be treated on its own merits. Apart from the local lesion, the following points must be carefully considered : (a) The age and vitality of the patient. An old person has less recuperative power than a young one, and hence a damaged limb may often be left in a youth WOUNDS 199 which one would certainly remove in an elderly person. The vitality of the individual is perhaps even more important than the age, for some men at sixty are in a much more healthy and resistant state than others at forty. The habits, as to temperance, etc., must also be taken into consideration, and the existence of general diseases, such as diabetes or albuminuria, might induce one to resort to radical rather than conservative measures. (b) The vitality of the extremity injured. A leg has to be sacrificed more frequently than an arm, since the vitality and reparative power of the latter are so much greater, (c) The septicity or not of the wound is of the greatest significance, since, if infection can be prevented, the chances of preserving the limb are greatly im- proved, and one would then often delay operation, whereas sepsis would turn the scale in favour of radical interference. The local conditions which suggest or determine the perform- ance of an amputation may be conveniently divided into two groups, viz., where amputation is essential, or where it is doubtful. A. Amputation is certainly called for — 1. To trim up the stump of a limb torn off by machinery, or cut off by a railway train, or carried away by a cannon-ball. 2. When the whole limb or one complete segment of it has been totally disorganized, or crushed to pulp, though still retain- ing its connection with the body. 3. In cases wdiere gangrene is imminent or has supervened, especially if it is of the spreading type. 4. When severe septic symptoms develop in a case where an attempt is being made to save a limb, the retention of which was from the first doubtful ; or when exhaustion supervenes from pro- longed suppuration. 5. In severe compound lacerations of the foot in old people, involving the bones and laying open the common synovial cavity. Septic arthritis and necrosis are then very apt to ensue, whilst the distance of the foot from the centre of the circulation increases the likelihood of gangrene. B. Amputation is doubtful in the following conditions : 1. Compound comminuted fractures in parts other than the foot do not pev se require amputation, even if neighbouring joints are implicated. By careful attention to antisepsis, free drainage, and the removal of detached fragments of bone and foreign bodies, which should usually be accomplished under an anaesthetic, limbs formerly condemned to amputation can not only be preserved, but also restored to a considerable degree of functional usefulness. The final decision will mainly depend on the age, condition, and previous habits of the individual. 2. When the soft parts have borne the brunt of the injury, and have been extensively stripped from the bones, amputation is by no means an essential, provided that they can be restored to their original position, that there is a reasonable probability of their A MANUAL OF SURGERY vitality being maintained, and that the utility of the limb will not be hopelessly impaired, as a result of lesions to the nerves, after the wound has healed. The surgeon has here to carefully balance the risk run if an attempt is made to save the limb, and the value that the limb if saved will subsequently be to the patient. For instance, when the muscles of the forearm have been extensively torn up in a machine accident, it is a question whether it is worth while exposing the patient to the risk of grave sepsis, when it is probable that under the best circumstances the limb will be of little practical use. 3. Laceration of the main artery of a limb need not in itself determine amputation ; but if in addition to this the bones, veins, or nerves are injured, and especially in the lower extremities of old people, amputation should be undertaken without delay. As to the Period when a limb should be removed after an acci- dent, there is no doubt that, as a general rule, the sooner amputa- tion is performed, the better ; the longer it is delayed, the greater the risk of septic infection and absorption. On the other hand, the shock in some cases may be so profound that it is better policy to delay interference until reaction is established ; this is especially the case in severe crushes close to the hip-joint, primary amputa- tion in this locality being frequently fatal. At the same time, if shock is being perpetuated by the presence of a crushed limb, it should be immediately removed. When sepsis is present, and it seems desirable to remove the limb, there is no need to wait until defervescence has occurred, as used to be taught ; as soon as the septic part is taken away, the fever and concurrent phenomena cease, provided that the amputation wound is maintained aseptic. III. Punctured Wounds and Stabs. — These may be brought about by any form of penetrating instrument, from a pin or needle to a sword or bayonet. The external opening may be in itself insignificant, the chief danger arising from the damage to deep structures — bloodvessels or nerves being divided, and serous cavities or viscera opened. The subsequent symptoms depend almost entirely upon the question of sepsis ; there is always con- siderable difficulty in efficiently draining the depths of a long and narrow wound, and therefore collections of pus readily form and burrow in all directions. Wounds resulting from the modern sword-bayonet, though very serious from their size and depth, are not so difficult to heal as those inflicted by the old triangular blade. They should be thoroughly syringed out with warm carbolic lotion (1 in 20), well drained, and the skin opening not allowed to close until all dis- charge has ceased ; if necessary, a counter-opening is made at a dependent spot. Serious haemorrhage or paralysis, indicating that important vessels or nerves have been divided, calls for PLATE VI. Skiagram of Hand, with Needle embedded in the Palm, close to the Carpus. To face p. 200.] PLATE VII. Splinter of Glass in Hand, close to Metacarpal Bone of the Index Finger. It will be noted that the glass casts quite as dense a shadow as the needle in Plate \ I. TofolUw Plate VI.] IVOUNDS immediate opening up of the wound, so as to expose and deal with the injured structures. The commonest punctured wounds met with in civil practice are those produced by needles, which are frequently broken off short in the body, especially in the hands, feet, knees, or nates. If seen soon after the injury, it is advisable to undertake their immediate removal, a proceeding sometimes very simple, but occasionally necessitating a deep and difficult dissection. Should the needle not be removed, it may travel about the body along the muscular and fascial planes, and there is no knowing where it may lodge or come to the surface, or how long it may remain in the body. It occasionally finds its ways into the pelvis of the kidney, and constitutes the nucleus of a renal calculus. One of the most troublesome and painful forms of penetrating wound is that caused by a fish-hook, since the barbed end catches in the tissues, and it is impossible to withdraw it without in- creasing the size of the wound considerably. The simplest plan of treatment is to push the hook on and make it protrude through the skin elsewhere to such an extent as to enable the barb to be cut away, when the remainder of the hook will be set free. For the detection of penetrating foreign bodies of a metallic nature, or of splinters of glass or stone, the so-called X rays of Rontgen are exceedingly valuable. They are produced by passing a powerful electric current through a modified Crookes tube, or, as it is now termed, a ' focus tube.' This consists of a thin glass bulb, into which are fixed two terminals— one, the negative, concave, and the other, or positive pole, a platinum plate set at an angle so as to reflect the rays generated at the negative end to the convexity of the bulb. A very high vacuum must be present in the tube. The rays thus generated, though invisible to the naked eye, have an actinic power, and are capable of affecting a photographic plate in the same way as ordinary sunlight. They are also able to penetrate many substances which are impermeable to ordinary light, although others resist their passage. Most of the soft tissues of the body are readily traversed, but bones and to a much less degree tendons are sufficiently resistant to cast a shadow on the plate, and it is the fixation of these shadows that constitutes the peculiarity of the so-called ' skiagram.' If a limb with a supposed foreign body within it is placed over a sensitive dry plate, held in a non-metalic dark slide or a black envelope, and the tube just above it, so that the convex portion on which the rays impinge is nearest the limb, a skiagram is produced which, on development, shows the osseous tissues, the outline of the limb, and the foreign body, if it exist (Plates VI. and VII.). A modification of this process has led to the production of the Cryptoscope. This consists of a cardboard screen coated with platino-cyanide of potassium or tungstate of soda, and if employed instead of a sensitive plate on the further side of the limb to the A MANUAL OF SURGERY tube, the appearances produced can be seen by the naked eye. Since it is possible in this case to move the limb from side to side, or to rotate it, a better idea can be obtained of the position of the foreign body ; by simple skiagraphy, it is often difficult to tell on which side of a bone the foreign substance lies. Still better results have been obtained by the application to this method of the principle of the stereoscope. Special methods of localizing foreign bodies have been introduced of late, but they are too complicated to be referred to here. IV. Gunshot Wounds. — It is impossible in a work such as this to go minutely into the subject of gunshot wounds, but it is essential to indicate their most important features, and in what respect they differ from other forms of injury already described. The character of a gunshot wound varies according to the nature of the projectile, the arm employed, the velocity of the missile, the distance from the body at which the firearm was discharged, the part of the body struck, and the direction of the shot. The wounds inflicted by the modern small-bore rifle (e.g., the Lee-Metford, Mauser, or Krag-Jorgenson) are very different to those produced in former days. The desiderata that have been considered in the evolution of the modern rifle have been to secure great muzzle velocity, a low trajectory, and clean and hard hitting. To this end the barrel has been rifled so as to cause the bullet to rotate on its own logitudinal axis (without such rifling the bullet would rotate on its short axis), and the bullet has been greatly modified, whilst the old form of gunpowder has given way to more highly explosive substances. The modern bullet is a long, thin, conical body, consisting of a core of lead hardened by the addition of 2 per cent, of antimony, enclosed in a cover, jacket or mantle of some smooth, hard metal, e g., 80 per cent, of copper and 20 per cent, of nickel (Lee-Metford and Mauser). The muzzle velocity is very high, amounting to 2,000 feet per second for a Lee-Metford rifle, and 2,300 feet per second for a Mauser The trajectory is nearly flat ; anything within 500 yards may be fired at point-blank, whilst in a range of 2,000 yards the bullet only rises 194 feet, as compared with 866 feet for a Snider bullet. The effect of these arms varies to some extent with the range, but not nearly so much so as was formerly maintained ; and although the worst wounds are usually produced at a short range, say 500 or 750 yards, yet quite simple wounds with no disruptive phenomena may also be caused at a similar distance. One of the best marked features of these wounds is that the bullet travels straight and direct, without lateral deviation or deflection, as was so commonly the case in the old days. Simple flesh wounds are of no great importance per se, granted that important vessels and nerves are not injured. The aperture of entry is small, and looks WOUNDS 20^5 somewhat ' like a bug- bite ' ; the aperture of exit is slightly larger, and tends to be a little more slit-like. A certain amount of extra- vasation occurs into the tissues around the track, but the external bleeding is often slight. There is but little tendency to carry in portions of clothing or septic material, and the wound heals by first intention if reasonable precautions are taken. The external cicatrices finally look very similar to those produced by bad acne pustules. Vessels and nerves are not likely to be injured unless they are actually in the line of the bullet ; the accurate limitation of the damage to this line is evident when one hears of a bullet passing between the abdominal aorta and the vena cava without either being injured. If a large artery is cleanly hit, the patient bleeds freely, and may die of haemorrhage, unless it can be con- trolled by a tourniquet. If the artery is button-holed, a traumatic aneurism may result, whilst arterio-venous wounds have been common in the recent South African campaign. There has been some difference of opinion as to the character of the injuries to bones ; that large masses of cancellous tissue (e.g., the lower end of the femur) can be drilled cleanly without fracture is certain ; but such wounds are sometimes associated with much splintering and involvement of neighbouring joints, possibly as a result of a short range, or of expansion of the bullet from the tearing down of the mantle. If a bullet hits cleanly the compact shaft of a long bone, it may smash the whole bone into small fragments, or the force may be more localized in its action, though always severe. Such comminuted wounds are very likely to become septic, if there is a long transport to the field hospital, and then fragments undergo necrosis and serious inflammatory phenomena may follow. Head wounds are much less fatal than might be imagined from the experimental work that has been undertaken. At close range frightful disruptive effects are produced which are almost certain to be fatal (see Chapter XXIII.) ; at a longer range comparatively little mischief is done, except along the line of the missile. The inner table is always more splintered than the outer, and of course a certain amount of brain substance may escape. Abdominal wounds are also much less serious than formerly, a mortality of 90 per cent. (American Civil War) being replaced by one of 40 per cent, in the recent campaign, and that without operation (Treves). The mere penetration of one or more coils of intestine is not sufficient to cause general peritonitis ; the wound is very small, and peristalsis seems to come to an end entirely as soon as the patient is struck, so that neighbouring coils of intestine or the omentum suffice to prevent faecal extravasa- tion ; indeed, many of the patients suffer but little constitutional or local disturbance. Of course, an empty intestinal canal is a favour- able condition, and this is not unfrequently present on the field of battle. Bloodvessels may be wounded in the mesentery, and death result from haemorrhage ; solid viscera, such as the liver 204 A MANUAL OF SURGERY or spleen, are often damaged but little, granting a fairly long range. On the whole, the effects of these modern bullets is to disable without killing, unless a vital part is struck. Soft-nosed Bullets {e.g., the Dum-Dum) are characterized by the mantle being absent at the top, whilst the lead core is usually free from antimony. The result of this is that as soon as the bullet strikes, the lead core mushrooms out, and terrible mutilation or destruction of surrounding tissues ensues, whilst bones are com- minuted and solid viscera pulped. A similar result follows from rubbing or cutting off the top of the Lee-Metford or Mauser bullet, or even from incising the cover in two or three places. Martini-Henry and Snider Bullets produce wounds which are intermediate in their severity between the preceding two. The aperture of entry is usually small, that of exit large and with everted edges. Portions of clothing are frequently carried in by these missiles, and add to the risks of sepsis. Shell Wounds have no special peculiarities beyond their severity and the ghastly nature of the injuries which may be inflicted by them, depending on the irregular shape of the fragments into which the shell bursts. Dangerous wounds may be inflicted by small shot, as, for instance, when one of the pellets enters the eye, whilst the wads or other portions of the cartridge may also be carried into the body. A blank cartridge, if discharged at a short distance, may produce a severe wound, and under such circumstances the skin around is likely to be burned and blackened, leaving a permanent bluish-black tattooing of the tissues. The Treatment of gunshot wounds is conducted in accordance with general surgical principles, although it may have to be somewhat modified by the patient's environment and by the fact that after a battle the pressure of work may be such that all lengthy operative procedures have to be discarded. The first essential is to protect the wound from infection, and for this purpose the small packet of antiseptic dressing carried by all our soldiers is admirable. Bleeding is, if possible, controlled by a tourniquet ; and splints must be improvised for broken limbs, if practicable. As soon as the wounded man reaches the field hospital, the wound is more thoroughly explored and cleansed ; foreign bodies are removed, bleeding points secured, and if the bullet has not escaped and can be readily detected, it should be extracted. When lodged deeply, various appliances have been introduced to locate the exact position of a bullet, e.g., Nelaton's porcelain-ended probe or more complicated electrical contrivances, such as the telephone probe. Skiagraphy has also a large field of usefulness before it in this direction. Comminuted fractures are carefully investigated, detached fragments of bone are removed, and if an attempt is made to save the limb, splints, etc., are carefully applied. Primary amputations for bullet wounds WOUNDS 205 are not very common at the present day, except when great com- minution of bone or hopeless involvement of vessels and nerves has occurred. Wounds of the skull always demand the most careful attention ; even when the bullet has penetrated cleanly and escaped, each opening must be trephined so as to allow of the removal of depressed splinters of the inner table. This rule holds good even when a bullet has merely ploughed a groove or track along the calvarium without penetration. The results of such treatment have been most admirable. The treatment of abdominal wounds produced by small-bore rifle fire is generally one of expectancy. It has now been abundantly proved that patients can recover in the m@st astonish- ing fashion from bullet wounds which have traversed the abdomen from side to side or from front to back, and therefore unless there is some very clear indication, operation is better avoided. Moreover, the practical difficulties connected with abdominal sections, the frequent lack of sterilized water, of towels, and the dirty condition in which the patient is, owing to the exigencies of the campaign, together with the length of time that such an operation takes — all these constitute reasons for not interfering unnecessarily. Abdominal distension from haemorrhage is one of the chief indications for laparotomy. In civil practice the ordinary rules of treatment are followed (Chapter XXXII.). V. Poisoned Wounds. — The great majority of poisoned wounds are due to some definite micro-organism, and we have discussed their nature and characteristics elsewhere. A few only remain to be dealt with here. Stings of Insects, such as bees and wasps, may be exceedingly irritating and painful, but are not dangerous, unless some local complication, such as erysipelas, supervenes, or the stings are very numerous, as when a swarm of angry bees settles on a person, or the part involved is such as to lead to serious swelling, as in the pharynx or tongue, cedema of the glottis possibly arising under such circumstances. All that is usually needed is the application of a weak alkaline lotion, whilst a common and efficient domestic remedy is a sliced fresh onion applied to the part. Care must also be exercised to ascertain that the sting and poison sac are not left in the body. Some varieties of flies and spiders are also extremely virulent, and it is possible that actual disease can be transmitted by the former. Thus, if a fly bites a person after feeding on putrid carrion, some form of septic inflammation may be originated ; anthrax may also be spread in this way. Mosquitoes, too, play an important role in the growth and development of filariae. Snake-bites require but little notice here, as they are exceedingly rare in this country, the common adder (Pelias herns) being the only venomous one likely to be met with, and even with this the 206 A MANUAL OF SURGERY poison is not sufficiently virulent to do much harm unless the individual attacked is a child or a person in a very bad state of health. The poison is conveyed to the wound from the glands and poison sac situated on either side of the upper jaw through fine canals in the specialized teeth, which open at their apices ; these teeth are so delicate in some snakes that it may be difficult to find the wounds produced by them. The effects of an adder's bite are not, as a rule, noticed immediately, but come on in the course of an hour or so ; extreme prostration supervenes, with a weak pulse, cold clammy perspiration, dilatation of the pupils, and perhaps delirium in bad cases, merging into coma. The Treatment consists in preventing the absorption of the virus by tying a ligature firmly above the wound, which should then be laid open so as to allow of free bleeding, and the surface excised or cauterized. The collapse resulting from absorption of the poison is best remedied by the administration of stimulants or the hypodermic injection of strychnine. In India and other countries many varieties of poisonous snakes are met with, and wounds are frequently fatal ; indeed, in India it is stated that 12,000 individuals are yearly destroyed in this way. The symptoms come on rapidly, and are extremely severe, although they are modified according to the variety of snake. The treatment must necessarily be more energetic ; probably the introduction of Fraser's antivenine will be the means of saving life. The Anatomical Tubercle, or Butcher's Wart ( Verruca necrogenica), consists in a papillomatous development usually on the knuckles or wrists, of those who are exposed to wounds either in the dead- house or slaughter-house. It is in all probability a manifestation of tuberculous infection, and, indeed, resembles somewhat closely the appearance of lupus when it develops on the hands. Treat- ment consists in the application of a powerful caustic, whilst in bad cases it is necessary to scrape the surface before cauterizing. Dissection or Post-mortem Wounds have obtained an unenviable notoriety as being fertile in the production of serious inflammatory disturbance, and although the graver forms are less common now than formerly, yet they are still met with occasionally. It is well known that bodies are most virulent within a few hours of death, and hence the post-mortem room is more frequently respon- sible for these affections than the dissecting room ; moreover, the care which is expended upon the preparation of subjects by in- jecting them with antiseptics reduces the dangers which might arise from the latter source. Inflammatory disturbances may arise under these conditions from several distinct causes : 1. The presence of strong antiseptics, such as arsenic, often irritates abrasions, and causes tenderness and congestion of the matrices of the nails. 2. The organisms occurring in actual putrid material have no WOUNDS 207 power of attacking living tissues, although some irritation may be caused by them if small sores or abrasions are present. 3. Pathogenic organisms are frequently found in bodies soon after death, and are especially virulent when developing in the exudations from serous membranes, such as the peritoneum, and hence both the surgeon who operates on the living subject, and the pathologist who examines the body after death, are alike exposed to serious risk either from an accidental puncture or from the infection of some abraded surface. It is even possible for infection to occur through the hair follicles of an unbroken skin. The lesions originated by any of these means vary in their nature with the method of inoculation, the virulence of the organisms, and the power of resistance of the individual. In the simpler cases all that ensues is a limited irritation of some abrasion or scratch, which rapidly disappears on the application of some sedative or antiseptic lotion. Suppurative folliculitis, or even boils, arise from infection of the hair follicles, and in worse cases the various forms of onychia, paronychia, or diffuse cellulitis, with or without suppuration in the nearest lymphatic glands. Severe toxaemic symptoms usually accompany the last-named conditions, and even acute septicaemia may develop. The immediate treatment indicated for a dissection wound is to tie a ligature or handkerchief around the base of the wounded finger, so as to encourage bleeding and prevent the absorption of toxic materials ; the part is then well washed under a tap of cold water, immersed in an antiseptic solution, and sucked for some minutes ; an antiseptic dressing must then be applied. Any inflammation which arises subsequently must be treated according to the general rules of surgery. A common result of poisoned wounds of the fingers, whatever their origin, is inflammation of the nail matrix (Chapter XIV.), or of the tissues of the fingers, constituting a whitlow ; and it will be convenient to describe the latter condition at this place. A Whitlow (Paronychia or Panaritium) occurs in four different forms, of which one is a true cellulitis, another a teno-synovitis, a third is a localized inflammation of the skin, and the fourth involves the terminal phalanx. (a) The Subcuticular whitlow consists merely in a development of pus beneath the cuticle which separates it from the cutis vera. It is very painful, but otherwise is of little importance A boracic poultice, preceded by the removal of the loose cuticle, is all that is needed in its treatment. (b) The Subcutaneous whitlow is a true cellulitis, commencing in the pulp of a finger, but often spreading upwards to involve the palm. The finger becomes swollen and painful, the pain being increased by pressure or by hanging down the arm. Gradually both these symptoms increase in amount, the back of the finger becoming cedematous, and the pulp more or less red. The swelling is at first hard and brawny, and even when pus is present it may be difficult to detect fluctuation unless the abscess is nearly pointing. Con- stitutional symptoms are not, as a rule, very severe, though the intensity of 208 A MANUAL OF SURGERY the pain may exhaust the patient. The hand should be elevated, and the finger poulticed. A free incision should be early adopted, but, though free, must not extend too deeply, or the tendon sheath may be opened and infected. Occasionally the pus forms at one or other side of the finger, and the incisions must then be suitably modified. Antiseptic fomentations may be continued after such an incision, the constant moisture adding greatly to the patient's comfort. (c) The Thecal form of whitlow is really a suppurative teno-synovitis of the flexor sheaths. The signs are much the same as in the former variety, only more severe, because the process is often more extensive. As special features may be mentioned the inability of the patient to bend the finger, and the extreme pain caused on attempting to do so, owing to the involvement of the tendon. The swelling also is more marked, and usually extends to the dorsum of the hand. It is important to remember that the flexor sheaths communi- cate with the common palmar sheath — always in the case of the thumb, usually in the little finger, but not in the index, middle, and ring fingers (Fig. 50). In the last case suppuration ceases at the level of the heads of the metacarpal bones ; but occasion- ally it oversteps this limit, and involves the palm in the same way as in the thumb and little finger. Free and early incision must be made to anticipate such extension, and also to limit as far as possible the adhesions which the tendons are liable to contract, or to prevent them from sloughing owing to the acuteness of the inflammation. In neglected cases the pus may burrow to the dorsum of the fingers, necessitating counter-openings ; or the peri- osteum may be affected, leading to disease or death of the phalanges ; the interphalangeal joints may also be disorganized. If the palm is involved, care must be taken in incising the abscess not to wound the superficial palmar arch or its branches. The incision should be made along the middle of the metacarpal bones involved, and not higher than the centre of the palm ; but an opening may also be necessary close to the level of the wrist-joint, and this can be made in the middle line without danger. (d) The Subperiosteal whitlow may be merely a complication of the thecal variety ; but it occasionally starts as an acute necrosis of the terminal phalanx, arising either idiopathically or as a result of infection from the nail matrix. The inflammation may be limited to the end of the finger, or may spread to the palm. Free incisions, and the removal of the bone, if dead, constitute the treatment required Repair of Wounds. In former days five different methods of repair were described, but increased knowledge and further research warrant us in making the statement that there is but one method of repair, which, however, is modified according to the conditions of the wound, and that this process is essentially the same whatever tissue of the body is involved, be it bone, muscle, tendon, or subcutaneous connective tissue. It must be noted that repair is not synonymous with regeneration. It is very unusual for any tissue which has suffered from a serious lesion to be regenerated ; Fig. 50. — Diagram of Syno- vial Sheaths of Flexor Tendons of Hand. (After Keen and White.) WOUNDS 209 fibro-cicatricial tissue, or some modification of it, forms the new- bond of union between the damaged parts. In a few tissues, how- ever, true regeneration has been noted — e.g., in striped muscle, bone, tendon, nerves, and glandular structures, provided the injured parts have been brought into close opposition. The general facts as to the process of repair may be stated as follows : The margins of the wound are always bounded by an area of tissue in a state of lowered vitality, even if no bruising or sloughing of the parts is present. The divided vessels are in a condition of thrombosis as far as the next patent branches, which in their turn are slightly dilated, partly as a result of this obstruc- tion and partly from the reflex irritation of the injury. The surface of the wound is generally covered with a film of lymph or blood- clot, whilst any spaces left in the interstices of the tissues are similarly occupied. (a) The first stage in the process consists in an abundant exudation of small round cells, presumably ieucocytes, whose function is to remove all dead or damaged tissue, as well as to break up, disintegrate, and finally absorb, any blood-clot which is present. These cells are derived from the surrounding vessels, and are accompanied by a certain amount of serous oozing, so that we have here the early manifestations of a slight inflamma- tory reaction, which, if it does not extend beyond certain limits, is a beneficial proceeding. Should it, however, become excessive, as when bacterial invasion is present, injurious results may follow. Much discussion has arisen among pathologists as to whether or not this stage of repair is to be considered inflammatory in origin ; the phenomena are, however, so exactly similar to those occurring in the earliest stages of inflammation that it is impossible to draw any line of distinction between them. (b) The exudation of leucocytes is soon followed by the appear- ance of a number of larger cells with more distinct nuclei, and in which cell division is always accompanied by karyokinesis ; these are termed fibroblasts, and are now considered the active agents in the reparative process. There is some difference of opinion as to the origin of these cells ; formerly they were supposed to be migrated leucocytes, but more recent researches indicate that they are derived from the multiplication of fixed or wandering connective tissue corpuscles or of the endothelial cells lining the neighbouring capillaries or lymphatics. Whatever their origin, they soon form a layer of cellular tissue which lies upon or between the surfaces or lips of the wound, whilst the previously effused leucocytes disappear, some finding their way back into the circulation, and others serving as pabulum for the nutrition of the fibroblasts. {c) The vascularization of this cellular layer forms the next stage in the process. This is brought about by the outgrowth from the walls of the nearest capillaries of solid rods of proto- J 4 A MANUAL OF SURGERY plasm (Fig. 51, (7), which appear first as minute buds, but rapidly increase in length, and may be single or double. They soon bend over to unite with similar threads growing out from other capillaries, or with the wall of another vessel (Fig. 51, b), or occasionally they unite with the vessel from which they started. The connective tissue cells may also become spindle-shaped, and send out branching processes to unite with the offshoots from the vessel walls. After a time these protoplasmic threads become canalized (Fig. 51, c), and a communication is estab- lished between them and the mother vessel, so that blood passes into them. The new capillary wall, at first homogeneous, soon Fig. 51. — New Vessel Formation. (After Tillmanns.) a, A small bud-like projection from the wall of a capillary; b, the union of such buds one with another, or with the branching processes of connec- tive tissue cells ; c, the canalization of these processes. becomes lined with definite endothelial cells, and strengthened by the connective tissue which forms around it. By this means a soft vascular tissue is produced, known as granulation tissue (Plate V., Fig. 2), consisting of loops of capillaries supported by large nucleated cells with a varying amount of intercellular substance, which soon becomes fibrillated in texture. (d) The transformation of this granulation tissue into ftbvo- cicatricial tissue is next proceeded with. Formerly it was sup- posed that the cells of the granulation tissue were themselves transformed into the fibres from which scar tissue is developed, WOUNDS but this idea is now abandoned in favour of one which maintains that the fibrillae are derived as an intercellular exudation. By the contraction of these fibres the cells become flattened out and compressed, and the newly-formed vessels constricted, so that as time passes the scar tissue becomes less and less vascular, and consequently firmer and denser, as well as smaller. (e) Whilst this last stage is in progress, the surface of the wound is covered over with cuticle, which spreads inwards from healthy epithelium in the neighbourhood of the wound, and especially from the deeper layers of the rete Malpighii. As already stated, the general process of repair sketched above Fig. 52. — Diagram of Healing by First Intention. (After Billroth.) The wound is occupied by a fibro-cellular growth, into which loops of capillaries extend, constituting granulation tissue, whilst the epithelium has united across the surface. is modified according to the character and condition of the wound. Four chief modifications are met with in surgery : 1. Healing by First Intention or Primary Union occurs in cleanly- cut aseptic wounds where the lips are unbruised and brought together, so that no extensive collection of blood or discharge between them is possible. A thin layer of blood-clot lies between the surfaces of the wound and penetrates into its meshes, and the contraction of this clot is at first the chief means of keeping the deeper parts in apposition. There is but a microscopic line of damaged tissue, which, together with the blood-clot, is easily absorbed, and the process runs a typical course, as sketched out above, union being effected in five to seven days. (See Fig. 52, and Plate VIII., Fig. 1.) 2. Healing by Granulation, or second intention, as it used to be termed, is met with (a) in cases where there has been definite loss 14 — 2 A MANUAL OF SURGERY of substance, so that the lips of the wound are not, or cannot be approximated ; as also (b) when the surface of the wound is bruised or damaged so that portions of tissue have to separate by sloughing ; or (c) when the advent of sepsis has prevented the occurrence of primary union. When a small amount of aseptic dead tissue is present, it is removed as previously described (p. 69) by an invasion of leuco- cytes from the surrounding vessels, which disintegrate and gradu- ally absorb it. These are followed by the fibroblasts, which form a layer of granulation tissue on the surface of the wound (Fig. 53). If there is much slough to be dealt with, the vitality of the granu- lation tissue cannot be maintained beyond a certain distance from its source of nutrition, and so by a process of simple anaemic Fig. 53. -Diagrammatic Representation of the Later Stages of Healing by Granulation. (After Billroth.) ulceration the unabsorbed dead portion is cast off and a granu- lating surface remains. If the slough is septic, ulcerative inflam- mation occurs in the adjacent living tissue, which brings about a similar result, though accompanied by suppuration and septic fever. When, however, there is a simple loss of substance, with no bruising or damage to the tissues, the course of events is as follows : The blood-stream in the superficial capillaries having been arrested, adjacent vessels become dilated, and from these an exudation of plasma and leucocytes results. The plasma coagulates on the surface and forms a layer of fibrin, entangled in the meshes of which are a number of white corpuscles, so that the wound becomes covered with a film of whitish-yellow material known as lymph. This gradually increases in amount and thickness, and is vascularized from below into granulation tissue, this process occupying from four to seven days (Plate V., Fig. 2). The healing of a granulating wound is brought about by the WOUNDS 213 conversion of the granulations into fibro-cicatricial tissue, and by the surface becoming covered with cuticle. The contractile tendency inherent in all cicatricial tissue produces two results from its presence in the base of the wound beneath the super- ficial layer of granulations : (i.) The surface area of the wound is diminished in all directions, a most important element in the healing process, since if the base is adherent to some dense resisting structure repair is slow and difficult, and the wound may remain open as a so-called chronic ulcer. When the granu- lating surface is very extensive, contraction may proceed to such an extent as to obliterate many of the vascular channels, and by thus depriving the superficial tissues of their adequate nutrition, the healing process may be indefinitely prolonged. (ii.) The depth of the wound is diminished, partly by the continuous growth of granulation tissue from below upwards, but also by the con- tractile base lifting the deeper structures to the surface. If the base of the wound cannot be raised, the cicatrix is usually depressed and adherent to the underlying parts. During the process of repair the wound takes on the appearances already described as characteristic of a healing ulcer (p. 63). 3. Healing under a Scab is a proceeding that can only take place in very small wounds, such as superficial grazes and abrasions, and is practically identical with the granulating process, except that, instead of an artificial dressing applied by the surgeon, the lesion is covered by a scab which consists of clotted blood or dried exudation. Should sepsis be present, pus is likely to accumulate beneath the scab and give trouble. 4. Healing by Organization of Blood-clot is only observed in strictly aseptic wounds where there is definite loss of substance, as in the deep channels made in the treatment of bones thickened by chronic osteitis. Blood is allowed to collect and coagulate so as to fill the cavity, and the surface is covered with protective to prevent irritation from the dressings. The dark coagulum shows no trace of change for some days, but gradually the peripheral portions become granular and yellowish-white in colour ; these are gradually vascularized and transformed into granulation tissue, which in time spreads over the whole surface from periphery to centre, and then healing occurs as described above. The clot is absolutely passive in this process, being infiltrated by leucocytes and removed by degrees, and thus merely serves as a basis of support or scaffolding for the building up of the granula- tion tissue which replaces it. A Scar is a mass of fibroid tissue covered by epithelium, which has been formed in the repair of a wound (Plate VIII., Fig. 2). It is at first vascular, and contains cells of the connective tissue type ; but after a time, as contraction continues, the cell elements become flattened out, fewer in number and less obvious, the intercellular 2i 4 A MANUAL OF SURGERY fibrous tissue more abundant, and the vessels constricted, so that finally a scar becomes well-nigh bloodless. Where superficial, its colour changes from red to white, and if of small size it may almost disappear, but never absolutely, unless the subcutaneous tissue has not been involved. When the parts around become injected by any cause, such as sharp friction, the anaemic scar tissue again becomes evident by contrast. Lymphatics, nerves, hairs, and cutaneous glands are all absent, except perhaps at the periphery, and the epithelial covering itself is merely a uniform layer without papilla?. The Pathological Phenomena connected with scars are as follows : i. Excessive Contraction, which may lead to great deformity, especially when the wound has occurred in the flexure of any of the joints. A web-like mass of fibroid tissue then forms, limiting movement, and requiring operative interference. A seriously burned hand may by cicatricial contraction be fused into an un- sightly mass, rendering the fingers of little use ; similarly, the chin may be drawn down and practically fixed to the sternum, and the lower lip everted, as the result of a burn on the front of the neck. The Treatment of such conditions consists in dividing the cicatrix, and thus freeing the parts, during which process it must be remembered that deeper structures of importance, such as the main vessels and nerves, may be adherent to the under surface, and thus be endangered. When once the scar has been divided, there is often no difficulty in restoring the parts to their normal positions, although when the contraction has existed for any length of time it may be advisable to do this slowly, even by gradual extension with a weight and pulley, so as to avoid any risk of lacerating the deeper parts, which are usually contracted secondarily. The raw surface formed by the opening out of the contraction has now to be covered with epithelium by some form of skin-grafting or by a plastic operation ; most of the cases can be dealt with by Thiersch's method, but the results, though promising for a time, are often ultimately disappointing. 2. Overgrowth of the scar tissue is sometimes met with, con- stituting what is known as the false or Alibert's Keloid. This most frequently occurs in the scars of burns or of wounds in tuberculous patients, but may arise from any cicatrix, presenting itself as a fibroid indurated mass of a dusky red colour, with perhaps a number of dilated vessels coursing over it, which occupies the region of the old scar, and may possibly send claw- like processes into neighbouring healthy structures. It consists merely of a hyperplasia of the scar tissue, but as to its aetiology nothing is known. With the exception of somewhat severe pruritus or itching, its presence entails no inconvenience, although if it occurs on exposed parts it may be very disfiguring. Removal is useless, since the keloid almost always recurs in the new ' . i u '■>* - o Cfi SfS ' — ' c « > —, re w w ide terec uld < o Pi 6 -a ° S re > ™ o ^ ^ i- S J i-i Ul O H 7. W hJ ^ < £ C O -rj o flS J Cfi The epit has ; very later > w < *li ,i'"*v * TO <-{ "7 ? > 0) - (/) re ,^i e "rt ^ re o ."S "J- 1 PLfl * ,0) ^ WOUNDS 215 cicatrix and in the stitch holes. After a longer or shorter interval it often disappears spontaneously. 3. Ulceration of Scars, the result of defective nutrition, is a troublesome condition to deal with, as repair is usually slow. 4. Painful Scars arise from either the implication of a nerve terminal in the cicatrix, or the pressure of a contracting scar upon the bulbous end of a divided nerve, as in amputation stumps. In each case further operation is necessary ; in the former the cicatrix, or at any rate the painful portion of it, is excised, whilst in the latter the stump must be opened up, and the enlarged end of the affected nerve removed. 5. Malignant Disease of Scars is of an epitheliomatous type, and appears as a hard tumour with everted edges, a thickened base, and usually a good deal of foetid discharge. The progress is very slow, since the vascularity of the tissue is slight. It is painless, from the absence of nerves, and as long as the disease is limited to the scar, no lymphatic implication will be noted. As soon, however, as the malignant growth invades healthy tissues, the usual phenomena show themselves. The diseased tissues may be freely dissected out, having regard to subjacent structures, and the wound closed by some plastic method. General Conditions connected with Wounds. I. Shock. — By the term 'shock' is meant a general depressed condition of the nervous system, resulting from some energetic stimulus, which is either transmitted to the vital centres in the medulla from the peripheral sensory or sympathetic nerves of an injured part, or may descend to them from a disturbance of the emotional centres through the nerves of special sense. Local Shock is a curious condition of insensibility to pain on handling, which is sometimes present after severe injuries, and is especially seen in gunshot wounds. Possibly it is due to some temporary paralysis of the sensory nerves. The term collapse is applied to a condition very similar in nature to shock, but differing from it mainly in its onset, which is gradual, and often preceded by some exhausting disease, and by the fact that muscular relaxation is more complete. The collapse of cholera is one of the most typical manifestations, but any condition associated with loss or derivation of fluids from the vessels may give rise to it, e.g., prolonged vomiting or serious haemorrhage. If at the same time septic absorption is taking place, the symptoms are still more marked ; thus in acute peritonitis the two factors, removal of fluid from the circulation and toxaemia, are proceeding concurrently. Shock usually tends to recovery, unless the lesion is of a serious nature, and then collapse may supervene and prove fatal ; thus, after rupture of the intestine the immediate symptoms are the result of shock, but they are quickly followed by the collapse due to acute peritonitis. The degree of shock experienced in any particular case is mainly influenced by the following factors : (fl) The severity and extent of the injury, w r hich may be calcu- 2i6 A MANUAL OF SURGERY lated either by the number of sensory nerve terminals affected, i.e., the superficial extent of the lesion, or by the depth to which the injury extends. Speaking generally, the amount of shock varies directly with the depth of the wound, since the deeper the wound, the greater the violence which has produced it ; but in some cases extensive superficial wounds produce a more severe effect than limited deep ones, owing to the larger number of nerves involved, along which stimuli can be carried to the centres ; thus, an extensive superficial burn is more likely to produce fatal shock than the complete incineration of an extremity. (b) The site of the injury. The more essential and sensitive the organ injured, and the more closely it is connected with the chief sympathetic or cerebral centres, the greater will be the shock ; thus, a small wound of the intestine, stomach, or any of the viscera, is much more serious than an extensive accident to one of the limbs. This fact is sometimes of practical value in the determina- tion of the exact nature of abdominal injuries. When severe shock with abdominal pain lasts for twenty-four hours after an accident, the surgeon may be almost certain that some internal viscus has been seriously damaged, and should at once consider the advisability of performing laparotomy. (c) The nervous susceptibility of the patient is a most important element, for the more highly organized the nervous system, the greater is the amount of shock experienced, and vice versa. Prison surgeons bear this out, for amongst the coarser and baser types of criminals operations may be performed without an anaesthetic in a surprising manner. (d) The expectation or not of the injury. When the whole nervous system is maintained in a state of tension, anxiously expecting the receipt of some painful impression, the effect produced will natu- rally be increased ; whilst if the attention is diverted, and interest actively aroused in other things, the shock at the time is much diminished, though its effects may be subsequently greater. Thus, in the keen excitement and nervous tension of a battle, soldiers have often been wounded severely, and yet not known it at the time ; whilst the pain of the most trifling cut may produce deep shock when the patient is in a state of dread and anticipation. The Symptoms vary with the injury inflicted, from a slight momentary giddiness and faintness (known ordinarily as an attack of syncope or a fainting fit) to immediate and complete prostration, insensibility, and even death. The pulse is at first small, slow, and weak, but soon becomes irregular, extremely rapid, and often imperceptible ; the countenance is pallid and shrunken, and the brow covered with cold sweat ; the respirations are slow and shallow, whilst the temperature is usually subnormal. After an interval, the length of which depends on the severity of the lesion and the treatment adopted, reaction occurs, being introduced by increased depth and frequency of the respirations ; WOUNDS 217 the pulse becomes slower and fuller, the surface warmer, whilst consciousness and muscular power are gradually restored. During this period it is not unusual for an attack of vomiting to supervene, probably due to hyperaemia of the brain following the anaemia which has been responsible for most of the preceding symptoms. When the accident or operation has resulted in serious loss of blood, the phenomena of haemorrhage are associated with those of shock ; the pulse is sometimes of the haemorrhagic type (p. 223) ; the blood is altered in its characters, and great restlessness may be present. Sometimes reaction is accompanied by great irritability, either of the mental or muscular systems ; in the one case leading to traumatic delirium, which is always of grave import, and in the other to intense restlessness, as in the shock which follows exten- sive burns. It is possible that in both these conditions a toxic element has been introduced. The term evethitic shock is some- times applied to these manifestations. Occasionally the evidences of shock are delayed in their ap- pearance for some time after the injury, and come on gradually. Especially is this the case after railway accidents when no great injury has been experienced ; for a time the anxiety and excite- ment are such that no depression is noticed, but as the mental perturbation passes off, the individual experiences symptoms very similar to the above, but probably rather of the nature of neuras- thenia than of real shock (see Chapter XXL). When an accident occurs to a person in a state of intoxication, it is not unusual for the phenomena of shock to be delayed for some time, only showing themselves when the effect of the alcohol has passed away. Pathology. — The post-mortem evidences are not very charac- teristic, but they all point to a loss of control of the nervous system over the vascular, resulting in anaemia of the brain and superficial parts of the body, and enormous engorgement of the abdominal viscera, lungs, and great venous trunks ; the heart contains practically no blood, although it is probable that the right side is much distended at the time of death, especially when due to sudden injury, and subsequently empties itself by post-mortem contraction. The explanation of the phenomena of shock is by no means simple, and several factors are probably needed to produce the complex result. 1. Reflex inhibition of the heart's action through the cardio-inhibitory centre in the medulla explains the early syncope with slow pulse. It is a well-known physiological fact that if a frog's abdomen is opened and the exposed intestine sharply struck, the heart stops in a condition of diastole, whilst if the vagi are previously divided, no effect is produced. Any severe peripheral injury may lead to such a result, especially those directed to the great sympathetic centres in the abdomen which are closely connected with the vital centres in the medulla. In this way sudden death may be produced by a severe blow in the 2i8 A MANUAL OF SURGERY epigastrium, or by drinking a glass of very cold water, when hot. Tins inhibition of the heart's action is never prolonged in mammals. 2. Inhibition of the vasomotor centre in the medulla is probably the cause of the maintained depression of the patient after an injury. This produces dilatation of the smaller arterioles, especially in the splanchnic area, and thus a marked lowering of the general blood-pressure follows. The supply of blood to the brain and surface is therefore diminished, the portal system being overfull. Most of the symptoms of shock can be explained in this way, although it is evident that a large haemorrhage ought to produce exactly the same effects. 3. A third factor has therefore been suggested in the production of shock, viz., exhaustion of the nerve centres, which thus lose their control over the muscular and circulatory systems. Diagnosis. — 1. From the general results of hemorrhage. Rest- lessness and thirst are then prominent signs, together with a sense of dyspnoea, causing rapid respiratory efforts ; the mental con- dition, moreover, is less affected, and the patient is generally sensible ; the surface is excessively blanched, and the pulse may have a marked haemorrhagic wave. 2. In concussion of the brain there are superadded to the symptoms of shock those more par- ticularly connected with the region affected, i.e., the intellectual centres, so that unconsciousness is the predominant feature, whilst loss of memory of the accident and of the events which followed is often noticed. 3. When vomiting is approaching under the influence of an anesthetic, the patient's pulse usually becomes weak and rapid, and the countenance pale. This condition closely simu- lates shock, and is often distinguished from it only by the progress of the case. Under such circumstances, if vomiting is plainly imminent, it is sometimes wise to increase the amount of anaes- thetic, as the patient is usually not fully under its influence. Treatment. — In slight cases very little is needed beyond resting quietly for a few minutes, or the exhibition of some aromatic stimulant to the nostrils, such as ammonia or smelling-salts. In the more severe cases the patient is laid recumbent, with the head low ; hot bottles, well protected, and blankets are applied to the trunk and extremities to maintain and increase the bodily tem- perature. If able to swallow, a little warm tea or stimulant may be administered ; but if unconscious, a hot coffee or brandy enema, small in bulk, or a hypodermic injection of ether or strychnine (11\_ ii.-vi. of the B.P. injection), is necessary. It must be borne in mind that the patient has, in most cases, only to be tided over a certain period of depression before reaction naturally follows, so that it is important to economize vital power, and not to waste it by over-stimulation. The injection of hot saline fluid (1 drachm of chloride of sodium to 1 pint of water) into a superficial vein, the rectum, or the subcu- taneous tissues (submammary or gluteal for choice), has been WOUNDS 219 employed with considerable success of recent years. The modus operandi of intravenous infusion is described at p. 224 ; the fluid should be introduced at a temperature between 105 and no° F. Several pints may be injected to begin with, the exact amount being governed by the reaction of the patient. If after a few hours symptoms of depression again supervene, the injection should be repeated. An important question is often raised as to the advisability of performing an operation during shock. As a general rule, it may be stated that operation should be deferred until reaction has come on, unless the presence of the injured organ, such as a badly crushed limb, is evidently prolonging the condition. Under these circumstances a hypodermic injection of morphia may improve the condition by relieving pain ; otherwise the condition should be at once dealt with, and it will be often found that, as the patient passes under the influence of the anaesthetic, the pulse improves, and the state of shock disappears, the anaesthetic shielding the medullary centres from the painful afferent stimuli. In urgent cases, especially when due to an intra-peritoneal lesion, where operation must be undertaken without delay, the use of a saline injection into the venous system prior to operation is often most advantageous. Shock may to a large extent be prevented during operation by a careful attention to such details as keeping the patient well covered up and as warm as possible, by perhaps operating on a hot-water table, by minimizing haemorrhage through bloodless methods of operating or the use of forci-pressure forceps, and by rapidity of execution. A hypodermic injection of strychnine, or a brandy and beef-tea enema, given just before the operation, is also useful ; and it must be remembered that incomplete anaesthesia tends to increase the shock rather than to prevent its occurrence. It is also advisable, in cases where the pulse is weak, to use ether rather than chloroform. II. Traumatic Fever. — Traumatic fever is that which follows the receipt of an injury, whether simple or compound, or after an operation. Two main varieties are described : (a) Simple Traumatic Fever occurs after subcutaneous injuries, such as sprains, contusions, fractures, etc., and after aseptic operation wounds or compound injuries. It is thus found in con- ditions where micro-organisms are absent, or, if present, are in such a state as to be practically impotent. The generally acknow- ledged cause is the absorption from the blood-clot or inflammatory exudation of some chemical substance (possibly the fibrin fer- ment), which has a pyrogenic effect upon the medullary centres. Probably the fever following aseptic operations is largely de- termined by the use of irritating antiseptics, which increase the exudation, and lead to considerable damage of the tissues ; if mild 220 A MANUAL OF SURGERY antiseptics or sterilized salt solution are alone used to irrigate open aseptic wounds, this so-called ' reactionary fever ' will be absent, unless other elements, such as retained serous discharge or accumulation of blood, are present. Occasionally fever is observed in cases where we have no grounds for supposing that absorption of fibrin ferment is taking place ; it may then be due to some peripheral irritation, e.g., a badly-fitting splint, and dis- appears immediately on the removal of the cause. The symptoms are those of slight pyrexia, reaching ioo° or ioi° F. within twenty-four or forty-eight hours of the injury, with coated tongue, loss of appetite, etc., gradually passing off in three or four days. If thus limited, it is of no prognostic importance. (b) Symptomatic Traumatic Fever is that caused by the absorp- tion either of the products of putrefaction, resulting from the vital activity of non-pathogenic organisms in discharges, blood-clot, or dead tissue ; or from the absorption of the toxins connected with a development of pathogenic organisms in the wound or its sur- roundings ; or from the supervention of some general infective disorder. All these different conditions have been dealt with else- where, and require no further notice. III. Traumatic Delirium. — -Although delirium is merely a symptom which is superadded to others in certain cases, it is occasionally of so pronounced a character as to demand special attention. Three forms are met with : (a) The Active Delirium, which accompanies severe injuries, particularly in plethoric, and often in previously healthy indi- viduals, whose environment has been suddenly changed from that of everyday life to a sick-bed in a hospital ward. Septic con- tamination of the wound is usually present, and the delirious state is associated and runs a parallel course with the traumatic fever. It is not usually of a violent type, although the patient may be irrational and restless ; he moves the injured part without any evident appreciation of the pain which, if conscious, he must suffer, but he is easily restrained by the exhibition of firmness and tact on the part of the attendant. The symptoms are most marked at night, and commence at the end of forty-eight hours, lasting, as a rule, for two or three days. There is a distaste for food, which, however, can be overcome by gentle persuasion. Treatment. — Patients in this condition must never be left ; the diet should be light, but nourishing ; the bowels are thoroughly opened, and an icebag to the head may be useful. The wound should be freed from any septic accumulation. (b) Delirium of a Low Muttering Type is met with in individuals of low vitality, exhausted by dissipation, drink, disease, or faulty hygienic surroundings. It is commonly associated with fever of an asthenic type, such as is seen towards the end of septic or infective diseases. The patient usually lies on his back, staring WOUNDS vacantly upwards, is incoherent, takes no notice of surrounding objects, and is observed to pick at the bedclothes and mutter to himself unintelligibly. There is often, in addition, an involuntary escape of urine or faeces. The mouth is generally open, the tongue dry, brown and cracked, and viscid mucus collects about the teeth (sordes). The Treatment should be directed to careful nursing and feeding, as by that means alone can the patient be saved. (c) Nervous Traumatic Delirium is observed in individuals who, previously of intemperate habits, have suffered some serious injury, such as a compound fracture. The violent symptoms do not set in till about the third day, but are usually preceded by some amount of sleeplessness and wandering at night, or the patient may have short snatches of sleep, from which he awakes semi-delirious. This gradually increases, and is followed by violent delirium of the worst type (delirium tremens), in which the patient is haunted by terrifying visions of reptiles, horrible insects, and the like, from which he tries in vain to escape. During this stage of excitement he is with difficulty restrained from jumping out of bed ; in many instances these patients are remarkably cunning, and, managing to elude the vigilance of their attendants, will succeed in escaping from the room by the door or window, and may inflict serious, and even fatal, injuries upon themselves or others. There is always a tremulous condition of the extremities and of the tongue, which is white and coated, whilst the bowels are obstinately confined. The pulse and temperature vary con- siderably, and the skin is often moist and clammy. The violent stage is always followed by profound exhaustion, in which the patient may gradually sink into a state of coma and die. In the case of a fractured leg, the struggles of the patient will cause con- siderable displacement of the limb, and necessitate constant attention to prevent further mischief. The limb should never be fixed to the bed, but slung in a Salter's swing or immobilized in plaster of Paris. Treatment. — In cases where an attack of delirium tremens is considered imminent, either from the previous history of the patient, the tremulous state of his hands and tongue, or his sleep- lessness, the best treatment to adopt is to support the strength by suitable food and a medium dose of stimulant, combined with free purging and, if need be, soporifics (chloral, bromide, paraldehyde, or morphia) ; under such a regimen the symptoms usually soon disappear. In the acute maniacal attacks the patient must be fully controlled and guarded, but with as little manifestation of restraint as possible. Nourishing food (possibly of a fluid type), w r ith a certain amount of stimulant, should be administered during the quiet intervals, and sleep obtained by drugs, especially morphia hypodermically ; a quarter of a grain should be given at first, and more if necessary. Free purging is of course essential. C H A P T E R IX. HEMORRHAGE. J >Y the term Jia inorr/iage is meant any loss of blood, whether in- significant anci immediately arrested by natural means, or more excessive and requiring treatment to prevent its continuance. Although most commonly due to some injury, whether sub- cutaneous or inflicted through the skin, it may be predisposed to by weakness of the vascular tissues, especially if associated with increased blood-pressure. Certain diseases, such as purpura and scurvy, are characterized by a tendency to bleeding, and there is one congenital condition, haemophilia, in which it is difficult to stop the flow of blood when once started. The character of the bleeding differs according to the vessel from which the blood escapes. Arterial Haemorrhage consists in a flow of bright scarlet blood, which escapes at first per saltum, i.e., in jets synchronous with the heart's beat, and may be derived, not only from the proximal, but also from the distal end of the divided vessel, if the collateral circulation is suffi- ciently abundant. If, however, it is derived from a deep artery, the blood may well up from the depths of the wound and not escape in gushes. In Venous Haemorrhage the flow is usually continuous, and the blood of a dark red or almost black colour. If, however, a large vein is wounded, such as the internal jugular, the blood may escape with a very definite spurt, owing to respira- tory or other influences. Capillary Haemorrhage is marked by general oozing from a raw surface, the blood trickling down into the wound, and filling it from below upwards. By Extravasation of Blood is meant the pouring out of blood from a wounded vessel or vessels into the lax areolar planes immediately adjacent, which become swollen and boggy. The usual constitutional signs will be manifested as a result of such extravasation, and, indeed, fatal haemorrhage may occur in this way without any escape upon the surface of the body. Subcutaneous or submucous haemorrhage is also met with in the form of small localized petechiae, arising from injuries, or from changes in the blood or vessel walls (as in purpura, scurvy, and septicaemia). Epistaxis is the term HEMORRHAGE given to bleeding from the nose. By Hseinatemesis is meant the vomiting of blood ; it may either have been swallowed, as in some cases of fractured base of the skull, where the pharyngeal mucous membrane has been torn, or it may have originated from the upper part of the intestinal tract. The blood is usually curdled and brownish in colour, somewhat resembling coffee-grounds, from the action of the gastric juice upon it. Haemoptysis is the title given to the escape of blood from the air-passages, whether it results from injury or disease. Hematuria is a condition in which blood is passed in the urine. By Melaena is meant the passage of dark tarry blood with the faeces. It is always an evidence of disease or injury to the intestine sufficiently far from the anus to allow the blood to become altered in character by the action of the intestinal juices. Blood derived from the rectal mucous membrane usually retains its bright red colour. Constitutional Effects. — If the haemorrhage is severe, as from division of a large artery, death results from syncope. The surface of the body becomes cold, clammy, and pale ; the lips, ears, and eyelids are livid ; the patient gasps, his respirations become quick and sighing, and death ensues after perhaps a few convulsive twitches of the limbs. If consciousness is retained at all, patients often complain of the sight failing, and a sense ot increasing darkness, immediately preceding the fatal termination. These effects depend as much on the rapidity of the bleeding as on the total amount of blood lost ; people can stand gradual loss of blood much better than when it escapes suddenly. If the haemorrhage is not so great as to kill immediately, the patient faints, and on recovering is in a condition of severe collapse and weakness, which continues for some time ; he is also liable to recurrent attacks of syncope, any one of which may be fatal. If the haemorrhage is more gradual, but continuous, as in cases of piles or uterine fibroids, the patient becomes profoundly anaemic, and the lips, ears, and conjunctivae are pearly white ; dyspnoea ensues, owing to the insufficient amount of blood present, and in consequence the patient is extremely restless, tossing about in bed. Any sudden exertion, or even sometimes the attempt to sit up, is followed by a sensation of faintness ; noises are heard in the ears, the sight becomes dim, or is even temporarily lost (amblyopia), and severe headache may be complained of, all arising from cerebral anaemia. The pulse often becomes what is known as hemorrhagic in character, i.e., frequent, large, and compressible, but collapsing entirely between each beat, and markedly dicrotic. These peculiar features are due to the sudden passage of a small amount of blood through a vessel which is practically empty and entirely collapsed. From the defective vis-a-tevgo, oedema of the extremities may result. During the continuance of haemorrhage the blood pressure necessarily falls ; but unless a volume equal to a third of the 22 4 A MANUAL OF SURGERY total bulk of blood in the body is lost, it quickly rises again to the normal after the bleeding has ceased. This rise in blood pressure is partly due to a diminution in the size of the vascular area, owing to vasomotor contraction of the peripheral arterioles and of the splanchnic area, but is also caused by an increased flow of lymph into the circulation. This lymph is accompanied by a large number of leucocytes, and hence well-marked leucocytosis, lasting for five or six days, always follows any severe haemorrhage. The number of red blood-cells is also reduced, whilst the amount of haemoglobin in each is diminished, and the specific gravity of the blood falls considerably. Children and elderly people alike bear the loss of blood badly : but whereas children rapidly recover from the immediate effects, elderly people do not. General Treatment. — When the loss of blood has been severe, the patient must be kept quiet with the head low, whether syncope is present or not. Stimulants may be necessary to maintain the heart's action, but should be given with discretion for fear of re- starting the bleeding. If death appears to be imminent, the arms and legs should be bandaged, or the abdominal aorta compressed in order to confine the blood as much as possible to the head and trunk. ' No patient should be allowed to die of haemorrhage.' Such was the dictum of the late Mr. Wooldridge, of Guy's Hospital, based on a knowledge of the value of transfusion and infusion. By Transfusion is meant the transference of blood from one individual to another ; it may be accomplished by two methods, the direct and indirect. Direct or immediate transfusion consists in injecting the blood of the donor directly into the vessels of the recipient. The objection to this method is that an individual can rarely spare sufficient blood to be of any real use, and hence the results are unsatisfactory. Indirect or mediate transfusion is carried out by whipping the blood from some healthy individual or individuals so as to remove the fibrin, and after straining through fine linen it is injected, either pure, or diluted with saline solution. During the last few years it has been recognised, however, that the success of this proceeding depends on the introduction of a sufficient quantity of fluid as a temporary substitute for the blood which has been lost, rather than on its quality ; for it has been proved that the transfused blood of another person is rapidly destroyed and eliminated. Hence transfusion has now been re- placed by what is known as Infusion, which consists in injecting large quantities of some bland fluid into the vessels, and by this means greatly improved results have been obtained. All the apparatus needed is a metal or glass cannula (Fig. 54), the end of which is bulbous, blunt, and bevelled, which can be tied into a vein, and connected by means of a rubber tube with a reservoir containing the fluid (Fig. 55). A vein, e.g., the median basilic or internal saphena, should be exposed, tied below and opened by a HEMORRHAGE 225 longitudinal or oblique incision ; the cannula, filled with lotion so as to exclude air, is then inserted, and a ligature placed round the vessel just below the bulb, so that on withdrawal it can be tightened. The amount injected varies with the circumstances and the effects produced, but, to be efficacious, some pints are usually needed ; 4 or 5 pints have not uncommonly been employed for the purpose. As a rule, one injection is all that is required in dealing with ha-morrhage, but where shock is present it may need to be repeated two or three times. Fir,. 54 — Cannula suitable for Infusion. Fig. 55. — Infusion into Vein of Forearm. As to the material, a warm saline solution is the best, consisting of a drachm of chloride of soda to a pint of sterilized water .(or (about -6 per cent.), at a temperature of 105 ° to no F. The dried crystals of salt should be dissolved in a small quantity of boiling water, so as to sterilize it, and this is then diluted to the required bulk. Of course, the apparatus is most scrupulously purified, either by boiling for some minutes or by effective immersion in carbolic lotion, and no air must be admitted. The injection is made slowly, so that the solution may be gradually mixed with the blood. It has been found by experiment that T 5 226 A MANUAL OF SURGERY after an infusion following haemorrhage the specific gravity of the blood is only lowered for a very short period, and rapidly rises to a normal level, or may even be raised above the normal. This suggests that the increased amount of fluid is sucked up by the tissues, and explains why it is sometimes necessary to repeat the injection more than once. Another plan sometimes used with success consists in the intro- duction of warm fluid into the rectum, or through an aspirator needle connected with a tube and funnel into the loose connective tissue of the buttock, abdomen, or submammary region. In the latter case the funnel must be held at some height in order to gain sufficient pressure, and by this means several pints may be injected. Natural Arrest of Haemorrhage. This can best be described under two headings, viz., (i) the temporary arrest, and (2) the permanent. The processes are much the same for arteries, veins, or capillaries ; but since the arrest of arterial haemorrhage has been more thoroughly investigated, and is the most important, we shall deal mainly with it. The Temporary arrest of arterial haemorrhage is brought about by three principal factors : (1) The coagulation of the blood, which occurs in and around the vessel, and without which death would ensue from the merest scratch. The greater the loss, up to half of the total amount of blood in the body, the more coagulable it becomes. (2) Diminution in the force of the heart's action always follows haemorrhage, from anaemia of the cerebral centres, a beneficent provision whereby coagulation is facilitated and the flow of blood checked. Unless the syncope is profound, stimulants should therefore be carefully avoided, for fear of causing a recurrence of the bleeding by increasing the power of the heart's beat. (3) Changes in and around the vessel play a most important part in completing the process. They consist in the retraction of the artery within its sheath by reason of its inherent longitudinal elasticity ; if, however, it is only partially divided (or, as it is called, ' button-holed '), this condition cannot obtain, and the haemorrhage is more likely to continue. As a result of this retraction, the rough and uneven inner lining of the sheath is exposed, and upon this the blood coagulates as it flows, thus gradually producing what is known as the external coagulum. At the same time the transverse muscular and elastic fibres in the vessel wall cause contraction of the open mouth, and thus, as the force and calibre of the blood-stream diminish, the external coagulum is able to increase in size by fresh deposits of fibrin, until at last its resistance is too great for the diminished cardiac impulse to overcome, and the sheath is filled with clot, which extends to the divided mouth of the vessel. From this an internal HEMORRHAGE 227 coagulum next develops, which sometimes extends upwards as far as the nearest patent branch. Thus the haemorrhage is arrested for the time being, and preparation made for — The Permanent closure of the wound in the artery, which merely consists in a modification of the general process of repair. After the cessation of the haemorrhage, the internal coagulum, soft in consistence and dark red in colour, extends from the mouth of the vessel, or from the site of the ligature, for some distance, and perhaps to the next collateral branch (Fig. 56). The vessel wall contracts upon this coagulum, with which, however, it does not unite, except at and near its base. As a result of the injury, a simple plastic arteritis is set up, evidenced by a hyperaemic condition of the vessel wall, due to dilatation of the vasa vasorum, Fig. 56. — Early Stage of Oblitera- tion of Artery after Ligature. The thrombus is seen above and below the site of ligature, that on the proxi- mal (upper) side being the larger ; commencing cell infiltration of the bases of the clots is also indicated. In both these diagrams the arteries throughout for clearness' sake; in tracted. Fig. 57. — Later Stages of the Same Process. The clots are shrinking, and the lowest portions are being transformed into granulation tissue. Proliferation of the tunica intima is also seen, reach- ing beyond the apices of the clots, have been represented of the same size reality, the lumen would be much con- and its infiltration with leucocytes, which also invade the coagulum and cause its base to become decolorized. The leucocytes break up the clot, traversing the natural lines of cleavage which result from its contraction, and gradually remove it, a few giant cells, probably derived from the leucocytes, occasionally assisting in this process (Fig. 59). The tunica intima proliferates con- currently, causing a secondary infiltration with the larger fibro- blastic cells in that part of the thrombus which is adherent to the vessel wall (Fig. 58) ; whilst a growth of cellular buds or granulations, which gradually increase in size and encroach on the lumen of the vessel, springs up in those parts where the apex of the clot lies free and unadherent (Fig. 57). Thus, the base of the 228 A MANUAL OF SURGERY clot is transformed into a cellular mass derived from proliferation of the tunica intima, and by the development of new vessels from the vasa vasorum into granulation tissue ; whilst the cellular buds which grow from the walls, and extend nearly to the next collateral branch, are also similarly changed. The free conical extremity of the clot contracts, and is gradually removed, partly by the activity of leucocytes which infiltrate it from the base, partly by the erosive action of the surrounding granulation tissue. A similar set of changes occurs at the distal side of the ligature in an artery tied in its continuity, although the thrombus is smaller and less firm. The ligature itself may be infiltrated by leucocytes, and replaced by granulation tissue, or may be en- Fig. 58. — Early Stage of Organization of Thrombus, to show the Infiltration of the Clot with Leucocytes and Connective Tissue Cells derived from the Endothelium. (Tillmanns.) A, Tunica media. B, Tunica intima, undergoing proliferative changes, and therefore thickened. C, Blood-clot lying in lumen of vessel, becoming infiltrated with leucocytes (small dark cells) and larger fibroblasts derived from the endothelium. capsuled. A rod of granulation tissue is thus developed, blocking the vessel, and this, by the usual process of repair, is transformed into a firm cicatricial cord in the course of a few months (Fig. 59). It must be clearly understood, however, that the presence of a coagulum is by no means essential to the obliteration of an artery. Thus, if the walls are merely brought into close and accurate apposition by a ligature without dividing the inner or middle coats, a proliferative endarteritis without any clot forma- tion results, which is quite sufficient for the occlusion of the vessel. The arrest of haemorrhage from veins and capillaries is more easily accomplished, the collapse of the walls, together with the HEMORRHAGE 229 formation of the external coagulum, being sufficient for this purpose. The later steps are similar to those occurring in an artery, except that there is but little internal coagulum. In capillaries, unless some constitutional condition such as haemo- philia is present, the mere falling together of the walls is sufficient to allow coagulation to take place, and thus stop the bleeding. Surgical Treatment of Haemorrhage. Many different methods are needed, under varying circum- stances, for the effective arrest of haemorrhage. It may be laid Fig. 59. — Organized Thrombus in Vessel, showing the newly formed Connective Tissue occupying the Lumen of the Vessel, and vascu- larized FROM THE VASA VASORUM. (TlLLMANNS.) Two giant cells are seen in the centre. down as a preliminary axiom that digital pressure over the bleeding-point will always temporarily check the most furious outburst, whilst means for its permanent stoppage are being arranged. Where the bleeding, though profuse, does not come from any one particular vessel, the following measures can be utilized : 1. Cold may be employed in the form of ice, cold water or lotion, or simple exposure to the air, all clots, rags, pledgets, etc., being removed for this purpose ; it must, however, be remembered that ice and unsterilized water may convey sepsis. Such treat- ment is of most value for general oozing from vascular structures or into cavities, such as the mouth, vagina, or rectum. 2. Position. — Where the bleeding is from one of the extremities, especially the lower, elevation is a most important factor in arresting it. The veins are emptied by the force of gravity, and 230 A MANUAL OF SURGERY this is always followed by a reflex contraction of the arteries, a proceeding of which surgeons also avail themselves in order to exsanguinate a limb previous to applying the rubber tour- niquet in operations which one desires to render as bloodless as possible. 3. Direct Pressure. — The skilful application of an antiseptic dressing, combined with pressure, is often effectual in arresting haemorrhage. General oozing from cut surfaces, which can be brought into apposition, as from an amputation wound, may be checked by applying a Arm bandage over them. In cavities or hollows, either natural or made by operation, bleeding may be stopped by plugging with strips of dressing, or by graduated layers of antiseptic wool. This form of packing has in a large measure taken the place of the old ' graduated compress,' which consisted of layers of lint devoid of antiseptic qualities, gradually increasing in size, superposed one over the other. Such dressings should be retained firmly in position for twenty-four hours, after which, if no further haemorrhage has occurred, the bandages may be slackened, but it is usually advisable to retain the deep plugs a little longer. 4. Hot Water (130 to 160 F.) is a powerful haemostatic. A certain proportion of carbolic acid or corrosive sublimate should be present to render the water aseptic, or it should have been previously boiled ; it must also be sufficiently hot, otherwise bleed- ing is encouraged rather than checked. It is supposed to act by stimulating the involuntary muscular fibres of the vessel wall to contract ; but probably the coagulation of the albumen of the blood is an important factor, as unless the water is hot enough to blanch the surface of the wound the bleeding is not stayed. 5. Chemical Agents may be used to check oozing from spongy parts, or bleeding from deep organs or cavities. If they are applied locally, and act primarily by causing coagulation of the blood, they are known as Styptics, or astringents. Such are the liquor ferri perchloridi or pernitratis, tincture of matico, tannic or gallic acids, alum, nitrate of silver, fibrin ferment, styptic colloid, cocaine, suprarenal extract (adrenalin), etc. If the drug is administered internally, and acts by increasing the coagulability of the blood, or by causing constriction of the vessels, it is termed a Haemostatic — e.g., opium, ergot, turpentine, hamamelis, acetate of lead, chloride of calcium, etc. In applying a styptic, it is essential that the surface of the wound should first be thoroughly cleansed, and all coagula removed. A portion of the dressing dipped in the solution is applied to the surface, or the drug is sprinkled or sprayed upon it. The objection to most of these agents is that healing by first intention is often hindered, whilst in the case of perchloride of iron extensive sloughing may result. Probably the most powerful styptic is suprarenal extract, which, however, loses its virtues when kept in solution for more than an HEMORRHAGE 231 hour or two. One of the dried tabloids (grs. 5) may be dissolved in 2 drachms of a 5 per cent, cocaine solution, and this is sprayed over the part, or applied on a piece of dressing. 6. Cauterization is not very largely employed for the arrest of haemorrhage, except from bones and from tissues thickened by inflammation, where retraction and contraction of the vessels are difficult. It need in no way interfere with primary union if the skin is not touched, for the minute sloughs formed, are quite aseptic, and will either be absorbed or cast off in the discharges. The chief objection to this method is the risk of secondary haemorrhage when the sloughs separate. The cautery is some- times used for the bloodless removal of vascular tumours, either as a galvano-cautery, or a Pacquelin's knife, or the ordinary clamp and cautery. It must be remembered that, in order to effectually seal the mouths of the vessels, the cautery must be at a dull red or black heat ; a bright red-hot iron cuts through a vessel as cleanly as a knife, and does not stop the haemorrhage. When the bleeding is more serious, mid originates from some definite vessel or vessels, other and more vigorous measures have to be adopted. Digital pressure suffices to arrest it for a time, whilst preparations are being made to ligature or otherwise treat the wounded vessel. If possible, a ligature should be applied with antiseptic precautions, but other means are used : 1. Acupressure was introduced by the late Sir James Simpson in order to obviate the use of ligatures. The introduction of aseptic absorbable animal ligatures has made such a method only necessary in exceptional circumstances. A needle is passed either under the vessel from the skin, or over the vessel from the surface of the wound, and, if placed accurately, is quite sufficient to stay the bleeding. With it, however, is sometimes combined the pressure of a loop of silk or wire passed figure-of-8 fashion around the ends of the needle. 2. Forcipressure is a plan of stopping haemorrhage by crushing the divided end of the vessel between the strong and deeply serrated blades of a pair of forceps with scissor handles pro- vided with a catch ; those known by the name of Spencer Wells are the most convenient. In dealing with small vessels, it is quite sufficient to leave the forceps applied for a few minutes, perhaps twisting them before removal ; but with the larger it is advisable to apply a ligature. In deep wounds where it is difficult, or almost impossible, to tie the vessel, the forceps may be incorporated in the dressings, and not removed for twenty-four hours. 3. Torsion was used as a means of sealing the ends of divided vessels before aseptic ligatures were introduced. It may be applied in two ways, viz., (a) Limited Torsion, which is employed for the larger vessels. The artery is drawn out of its sheath for about half an inch with one pair of forceps, and held close to the tissues 232 A MANUAL OF SURGERY by another pair applied transversely, whilst the grasped end is twisted sufficiently to thoroughly close it ; it should not, however, be twisted off. (b) Free Torsion is used for the smaller vessels which cannot be so completely isolated from surrounding struc- tures ; the vessel is laid hold of with its sheath or connective tissue covering, and twisted as much as necessary. The effect of torsion is that the inner and middle coats are ruptured just above the spot grasped, and tend to curl upwards into the lumen of the vessel, whilst the outer coat is twisted up beyond. A coagulum forms upon the injured structures, and the subsequent processes to secure permanent occlusion are similar to those described above. The advantages claimed in favour of torsion are that it is easier to twist the vessels than to tie them, that there is less liability of secondary haemorrhage, and that no foreign body is left in the wound. As to the ease of application, it is doubtful whether torsion has any advantage over ligature, and certainly when asepsis is maintained the two last statements do not hold good, for secondary haemorrhage is practically un- known in aseptic surgery, and the catgut ligature is not more of a foreign body than the damaged end of a twisted vessel. Torsion is, however, occasionally useful in plastic work. 4. Ligature is at the present day the method most frequently employed for arresting bleeding from a definite source. The material used should be of sufficient strength to secure the vessel, of sufficient resistance to maintain its hold in spite of being soaked in the body fluids, and yet of such quality as to be finally absorbed, or so pure and unirritating as to become encap- suled in the tissues. Catgut suitably prepared is the substance most frequently employed, but inasmuch as commercial catgut, even when rendered aseptic by immersion in carbolic acid, swells up in warm blood serum, and becomes a soft, pulpy mass in half an hour, it is necessary to harden and render it more resistant by steeping it for twelve hours in a solution of chromic acid (5 parts of gut to 1 of chromic acid in 100 parts of water), and subse- quently for twelve hours in 100 parts of sulphurous acid solution. It is then dried, and is of a greenish colour. It must not be forgotten that catgut is prepared from sheeps' intestines, by allowing the latter to putrefy in water and then scraping away the mucous and muscular coats, leaving only the submucous tissue with its elastic fibres, which is twisted up into long strands. It is obvious that very efficient sterilization is necessary to make a material thus prepared fit for surgical work (p. 18). Sterilized silk is another agent employed, whilst animal tissues, such as kangaroo tendon and strips of ox aorta, have their advocates. Ballance and Edmunds advise the use of gold-beaters' skin, prepared from the peritoneum of the ox, as a material for tying vessels in their continuity, and excellent results have followed its employment. Recently a celluloid ligature has been introduced, and holds out HEMORRHAGE 233 Reef Knot prospects of replacing by a safe and harmless material all these more dangerous animal preparations. Ligatures may be applied either to the divided end of an artery in an open wound, or to an artery in its continuity, the effects and final means of occlusion being in both cases very similar. When applied to the open cud of a divided vessel, care should be taken to select a ligature the thickness of which is proportionate to the lumen of the vessel to be tied. The artery should be cleanly picked up with forceps, so as to include as little surrounding tissue as possible, and where a sheath exists, should be with- drawn from it. The ligature is then passed round it and tied in a knot which will not slip, e.g., the reef knot (Fig. 60). When the application of a ligature is difficult, as in very dense fibroid tissue, it may be advisable to pass it under the vessel by means of an ordinary curved needle, and then to tie it. For ligation in continuity, see p. 280. Effects of Ligature — 1. On the Vessel Wall. — The immediate result, if the vessel has been tied in the usual way, is to divide the inner and middle coats, which are separated from the outer and curl up slightly, whilst the outer coat is con- stricted and thrown into folds within the grasp of the ligature (Fig. 61). If an artery is tied in its continuity, the same effect is produced on each side of the ligature. The changes already described, by means of which the artery is obliterated and transformed into a fibro-cicatricial cord, then mani- fest themselves in due order. An exudation of plastic lymph and cells occurs into the sheath and around the ligature, and if the latter is aseptic, the whole is embedded in this plastic mass, which undergoes the ordinary changes seen in repair. If the ligature, how- ever, is septic and irritating, it has to cut its way out through the vessel wall by an ulcerative process akin to the separation of a septic slough, thus ex- posing the patient to the risk of secondary haemorrhage from the disintegration of the internal coagulum. The period at which a septic ligature is separated varies with the size of the vessel, from a week or eight days for an artery the size of the radial Fig. 61. — Effect of Tying a Ligature firmly around an Artery. The ligature was tied at two levels, and the artery then laid open longitudinally. 234 A MANUAL OF SURGERY or ulnar to twelve or fourteen clays for the subclavian or carotid. Of late years an old idea has been resuscitated, and has gained a considerable amount of support from some surgeons, viz., that occlusion of a vessel is satisfactorily accomplished by merely bringing the walls into close apposition by an animal ligature of suitable size, and that division of the inner and middle coats is not only unnecessary, but prejudicial, and favours secondary haemorrhage. Where asepsis is fully maintained, satisfactory occlusion follows either plan ; but it appears to us that the division and curling up of the inner and middle coats must facilitate the deposit of fibrin and process of repair. At any rate, it would seem safer to apply a ligature to a main vessel on the face of a stump with sufficient tightness rather than to err on the other side. In cases where, perforce, the artery must be tied at a spot where extensive atheroma or calcareous degeneration is present, it may be advisable to use broad animal ligatures, such as strips of ox aorta (Harwell), or prepared portions of gold-beaters' skin, and only to tighten the knot sufficiently to occlude the vessel with as little damage to the coats as possible. The same plan must also be adopted in dealing with arteries of great size, such as the innominate, the first part of the subclavian, or the common iliac ; the non-observance of this precaution results in aneurismal dila- tion at the point of ligature, and this to secondary haemorrhage and death. It is a well-known fact that all arteries are maintained in the body more or less upon the stretch, as evidenced by their retrac- tion within the sheath on complete division. A certain amount of longitudinal tension must therefore always exist upon any part of an artery to which a ligature has been applied in its continuity, a condition which may presumably predispose to secondary haemorrhage. To obviate this, it has been suggested that two ligatures should be applied, and the vessel divided between them. This plan may be used with advantage in situa- tions where the artery is easily accessible, but is scarcely feasible in some of the deeper operations. 2. The Ligature itself undergoes changes, which result in its partial or total absorption, if such be possible, or in its becoming encapsuled if absolutely unabsorbent. The leucocytes attack any soft material, such as silk or catgut, insinuating themselves amongst the fibrillae, and finally remove them by a similar digestive process to that which leads to the absorption of a small aseptic slough. Multinucleated giant-cells are often present, and probably take some part in the proceeding. Finally every trace of the liga- ture disappears, and its place is taken by fibrous tissue, incor- porated with that arising from the end of the vessel. Chromicized gut usually lasts for about a fortnight, but not unfrequently much longer ; silk is similarly attacked and removed, but more slowly. HEMORRHAGE 235 Other animal substances employed are dealt with in the same way, and even silver wire is not unaffected, its surface becoming roughened after a time and slightly eroded. 3. The effect on the Circulation is the same whether ligature or any other plan of occlusion is adopted. The passage of the blood through the vessel ceases, and its proximal end as far as the next patent branch, though remaining somewhat distended for a short time by the impact of the blood-stream, soon begins to contract, and is ultimately converted into a fibrous cord, which may or may not be pervious for a short distance. Blood is conveyed to the vessels of the limb below the ligature by anasto- mosing branches which rapidly undergo dilatation, and establish a collateral circulation, sufficiently free as a general rule to main- tain the vitality of the part. These collateral branches become permanently enlarged, lengthened, and tortuous, and their walls thickened. If for any reason the collateral circulation is in- sufficient, gangrene is likely to supervene, starting in the parts furthest away from the centre of the circulation, or in the structures of least vitality, and spreading upwards until a part is reached which receives enough blood to keep it alive. Arterial Haemorrhage. Three forms of arterial haemorrhage are described, viz., primary, reactionary, and secondary. Primary Arterial Haemorrhage is met with under two conditions — from an open wound, or where an artery is ruptured or punctured subcutaneously, so that extravasation into the tissues occurs, constituting either a severe bruise if the artery is small, or if the vessel is large what has been badly termed a ' diffuse traumatic aneurism.' The general rules for the surgical treatment of both these conditions are identical, and although the agent employed to finally arrest the bleeding varies according to the surgeon's personal predilections, yet the underlying principles hold good in all cases. We shall limit ourselves mainly to speaking of the ligature, as we almost always employ this agent. A. Primary arterial haemorrhage from an open wound. The blood is here poured forth upon the surface, and escapes freely, so that the full constitutional effects are experienced. The principles that guide us in the Treatment of primary arterial haemorrhage were first recognised by the late Mr. John Bell, but the importance of acting upon them, and not trusting to the Hunterian plan of ligature at a distance, was first fully insisted upon by Guthrie, whose large experience, confirmed by that of later surgeons, demonstrated their accuracy. They may be enunciated as follows : 1. That the vessel must be secured at the bleeding-point, an operation to expose it being undertaken if necessary. However infiltrated 236 A MANUAL OF SURGERY the part, the rule of cutting down to expose the wounded vessel is to be adhered to, with one or two exceptions noted below, and this for two reasons : (a) It is often impossible to know the exact source of the haemorrhage unless it is laid bare. Thus, the bleeding from a punctured wound of the front of the leg, which was apparently derived from the anterior tibial artery, was proved on incision and careful dissection to come from the peroneal, the puncture having passed between the bones. In the axilla and groin such uncertainty often exists, (b) Proximal ligature of a vessel at some distance above the bleeding spot is very commonly insufficient to arrest the haemorrhage, since collateral circulation is quickly established, or, though apparently effective for a time, reactionary haemorrhage is very likely to ensue. 2. That both ends of the wounded vessel must be secured if it is completely divided, whilst if it is only punctured, a ligature must be placed on each side of the puncture, and the complete division of the vessel effected. The ease with which collateral circulation is established justifies such treatment in the case of all arteries of large size. Thus, where the facial artery is divided, jets of blood are emitted from each end quite freely, and with nearly as much force from the distal as from the proximal. Occasionally the distal end of a bleeding vessel retracts amongst the infiltrated tissues to such an extent as to render its isolation impracticable. The surgeon must then trust to plugging of the wound from the bottom, but not until every effort has been made to secure it. It is only needful to undertake the measures detailed above in cases where primary haemorrhage is actually proceeding. If it has been once arrested, it is unnecessary to search for the bleeding spot unless the patient is very faint and collapsed, and the surgeon has reason to anticipate that a large trunk has been injured. Under such circumstances it may be needful to seek for and tie it at once, otherwise recurrent haemorrhage is likely to ensue when the heart's action becomes more vigorous. There are a few exceptions to the general rule of tying a wounded vessel at the injured spot, e.g., where the depth of the dissection needed might endanger important parts, as in dealing with the deep palmar and plantar arches, or with the secondary branches of the carotid. In the actual treatment of any particular case, temporary arrest of the bleeding may usually be effected by digital compression either of the bleeding point or of the main trunk at a favourable spot nearer to the heart, against some resisting structure, such as a subjacent bone. The common carotid is controlled by grasping the neck from behind, and compressing the artery by the fingers placed along the anterior border of the sterno-mastoid against the transverse process of the sixth cervical vertebra (Chassaignac's tubercle). Such pressure will also control the vertebral and inferior thyroid vessels. The subclavian is to be compressed in the HEMORRHAGE 237 third part of its course against the first rib by the finger or thumb placed immediately behind the clavicle, the palm of the hand resting over the shoulder. A good deal of force is required in order to maintain the pressure, and this may be gained by super- imposing the fingers or thumb of the other hand. Where the pressure is to be kept up for some time, the handle of a doorkey well padded may be employed in the same way, or an incision may be made and the vessel exposed, and directly controlled by digital pressure. The facial artery is compressed against the lower jaw just in front of the masseter muscle. Bleeding from the labial and coronary arteries is commanded by inserting the index- finger into the corner of the mouth, and compressing the lip between it and the thumb outside. The temporal artery should be compressed against the zygoma just in front of the ear, the occipital at a spot about i\ inches from the occipital pro- tuberance against the superior curved line. To control the brachial artery, the arm should be grasped from behind, and the fingers pressed inwards along the inner margin of the biceps against the humerus. The radial and ulnar arteries are easily commanded just above the wrist by using both hands to grasp the forearm, one for each vessel. The abdominal aorta is tem- porarily controlled in slim individuals with ease by pressure through the abdominal wall against the body of the third lumbar vertebra at a point a little above and to the left of the umbilicus, i.e., just above its bifurcation ; in stout persons this is impossible. The common femoral artery is best compressed just below Poupart's ligament. The surgeon should stand on the same side of the patient as the artery to be controlled, and use either the finger- tips or thumbs to press the vessel upwards and backwards against the pubic ramus. The fingers of one hand placed over the other may sometimes be necessary to maintain sufficient command, or the thigh may be encircled by the two hands, and one thumb laid over the other. Care must be taken not to let the vessel roll to one side or the other, and so escape compression. When the artery has to be controlled for some time, as in an amputation, the hands may be used alternately, the one to rest the other. Such pressure will suffice for the temporary arrest of haemorrhage from any part of the lower limb. If it is desirable to control the anterior and posterior tibial arteries close to the ankle during opera- tions upon the foot, the assistant who steadies the limb accom- plishes this by grasping the toes with one hand, and with the other compressing the vessels, the posterior tibial at a spot a finger's breadth behind the internal malleolus, the anterior midway between the two malleoli. As digital compression cannot, however, be comfortably main- tained for long, mechanical compression of a limb as by tourniquet or elastic bandage must be resorted to. Possibly the screw , tourniquet will be the best to apply, as it can be relaxed and 238 A MANUAL OF SURGERY tightened again as often as is necessary during the operation. In some cases it is advisable to exsanguinate the limb by eleva- tion before applying the tourniquet. The wound is then, if need be, enlarged by incisions, which whilst freely laying the parts open should inflict the least possible damage on surrounding structures. All coagula are removed, and the wounded vessel looked for. It may be needful to relax the tourniquet, and allow a jet or two to escape, in order to ascer- tain its position. Both ends should be sought for and tied, a proceeding easier said than done. This especially applies to the distal end, which retracts, and often does not bleed at the time of operation, but may do so when the collateral circulation becomes established. B. For Subcutaneous Rupture of an Artery, see p. 247. Recurrent, Intermediate, or Reactionary Arterial Haemorrhage. Such are the terms applied to bleeding which recurs within twenty-four hours of an accident or operation. Its occurrence is an evidence of the failure of the means employed to per- manently arrest the primary loss of blood, and may result from two chief causes : (a) Defective application of a ligature, which comes undone from being badly tied (a 'granny' knot), or slips off from including within its grasp other structures as well as the arterial wall; or (b) the coagula lying in the mouths of divided vessels are not sufficiently firm to withstand the increasing blood- pressure which supervenes after the shock has passed away, or which may be due to excitement or the injudicious administration of stimulants. It is usually due to the second of these causes, and is then not very serious, inasmuch as it can only arise from the smaller vessels, all the larger ones having probably been recognised and tied during the operation. The term should not be applied to the oozing of blood or blood-stained serum so common after operations, but only used for those cases which demand treatment, and where considerable pain and tension are caused by the accumulation of blood in the wound. Treatment. — Elevation and the pressure of a firm bandage are often quite sufficient to arrest this form of bleeding; but if un- successful, the wound must be opened up, washed out w r ith hot or cold lotion, and any bleeding vessel tied. The actual cautery may even be employed to check oozing from cicatricial surfaces, and if it is not allowed to touch the skin, and the wound kept aseptic, no delay in its healing need be occasioned. Should the bleeding persist, antiseptic plugging must be resorted to. HEMORRHAGE 239 Secondary Haemorrhage. Under this title are included all forms of haemorrhage from wounds which occur after the lapse of twenty-four hours. It is usually due to sepsis, and was formerly very common, being a frequent cause of a fatal termination ; but since the introduction of antiseptic surgery it is but seldom seen. Where antisepsis, however, cannot be efficiently carried out, as in the mouth, pharynx, etc., it is still occasionally met with. The Fundamental Cause in the production of secondary haemor- rhage is without doubt a septic condition of the wound. This may act in various ways. Thus, in a vessel entirely divided, the cocci may gain entrance through the open mouth to the internal coagulum, and by causing its disintegration, break down the barrier which Nature had raised against such an occurrence. This process is assisted by an ulcerative form of periarteritis, which leads to the maceration and softening of an absorbent ligature, and to weakening of the vessel walls. It is in this latter way that secondary haemorrhage is induced in vessels ligatured in their continuity, the loss of support due to the opening up of the septic wound being also an element of danger. We desire here to emphasize the marked alterations in all the conditions existing in a septic as opposed to an aseptic wound. In the latter it is not only the clot in the lumen of the vessel which is relied on to prevent accidents, but the vital action of all the tissues is calculated to work in the same direction, that of ensuring the patient against haemorrhage ; in fact, the occur- rence of secondary haemorrhage in an aseptic wound is almost impossible. On the other hand, when sepsis supervenes, a destructive process replaces that of repair, and the activity of the part is temporarily paralyzed by the toxic influence of the micro-organisms and their products. Various other conditions may be mentioned, however, as Con- tributory Causes of secondary haemorrhage : (i.) The ligature may be coarse, irritating, or septic, or it may consist of material too readily absorbed. (ii.) Its mode of application may be faulty. Thus, it may have included other structures, and so becomes loose, offering an insufficient bar to the blood-pressure ; or the sheath may have been opened too freely, and thus the vitality of the vessel wall dependent on the vasa vasorum is diminished. In large vessels, such as the innominate and first part of the subclavian, the mere division of the inner and middle coats weakens the wall to such an extent as to render it incapable of withstanding even a normal blood-pressure, so that aneurismal dilatation and secondary haemorrhage are almost certain to result, even in aseptic cases, (iii.) The ligature may have been placed too near a branch immediately concerned in the establishment of 240 A MANUAL OF SURGERY the collateral circulation (though if asepsis is maintained this is comparatively unimportant), or where there is a considerable back-flow, or the part may not have been kept absolutely at rest, (iv.) The condition of the arterial wall at the site of ligature may be unhealthy, being possibly the seat of atheroma or fatty de- generation, a most important complication if the wound becomes septic, (v.) The state of the blood may be unfavourable to the repair of any wound, whether in an artery or not, e.g., in albu- minuria or diabetes, (vi.) Increased blood-pressure after the ligature of a vessel may lead to secondary haemorrhage, as in plethora, Bright's disease, traumatic fever, or from injudicious excitement, or the unwise administration of stimulants. The Phenomena are usually preceded by those of septic con- tamination of the wound, to which a slight occasional loss of blood is added. This continues with more or less frequency and severity, until either the patient is worn out by the constant repetition of small losses, or is destroyed by one or two severe gushes from the larger vessels. The earlier the bleeding occurs, the less serious it is, as it probably comes from the smaller vessels, and can be easily dealt with. When, however, it does not supervene till late, as on the tenth or twelfth day, it usually arises from the larger trunks, and is increasingly severe. When originating from a vessel tied in its continuity, it generally comes from the distal end, and that for the following reasons : (a) The internal coagulum is here less firm, and forms later. than at the proximal end ; (b) the pressure at the distal side of the ligature, which is at first nil, is continually increasing as the collateral circulation is established, whilst proximally it gradually diminishes as the vessel contracts, and the blood-flow is deflected into other channels ; and (c) the main vasa vasorum always run into and along the vessel wall in the same direction as the blood- stream. Hence the effect of isolating the artery in its sheath and ligating it is to diminish the vitality of the arterial tunics and to impede repair just below the point of ligature. The Treatment is a matter of grave anxiety until the wound gets into a healthy state, inasmuch as the surgeon can never be certain that the bleeding will not break out again, although it may have been temporarily stayed ; hence such a case must be most carefully watched. If the wound is in a limb, a tourniquet should be lightly adjusted above it as a precautionary measure, so that at a moment's notice it may be tightened. When arising from an artery entirely divided across, as in an amputation stump, elevation of the part, exposure to the external air, bathing it with cold lotion, and then redressing and firmly bandaging it, may be all that is needed in the early and mild cases. A recurrence will necessitate the reopening of the wound, and the application of ligatures to the bleeding points, if practicable. The actual cautery may be employed where the tissues are too HEMORRHAGE 241 rotten to hold a ligature. Means should be adopted to remove septic sloughs, as by a Volkmann's spoon, and if possible to render the wound aseptic by swabbing it out with strong carbolic lotion (1 in 20), or with a solution of chloride of zinc. The wound should then be powdered with iodoform, packed with cyanide gauze, and firmly bandaged. If occurring later in the case, the wound should be freely opened up, and an attempt made to secure the bleeding vessel by isolating it for some little distance from surrounding structures. If this fails, owing to the sloughy or septic state of the tissues, the artery must be tied just above, or re-amputation performed. When the bleeding comes from the main vessel near the trunk, as after amputation at the shoulder or hip, proximal ligature can alone be depended on, should local treatment be unsuccessful. When coming from an artery tied in its continuity, the means indicated above should be adopted in the early stages. Later on, the treatment varies a little according to the situation. If from a vessel of the trunk, such as the carotid or iliac, the wound must be freely opened up, and the artery secured again above and below, whilst every effort is made to combat the septic condition by plugging with antiseptic materials. Failing this, if proximal ligature is impossible, one can only trust to pressure. In the arm, after using cold, pressure, and elevation, one would re-tie above and below through the original wound. If this fails, a ligature should be applied higher up through a separate incision, or finally amputation be performed. In the leg, however, it is scarcely wise to attempt re-ligature at a higher spot, owing to the less abundant collateral circulation. If the haemorrhage ceases, gangrene is very likely to ensue ; whilst if the latter does not supervene, haemostasis will probably not be effected. Under such circumstances amputation must be undertaken without delay. Venous Haemorrhage. Bleeding from the smaller veins rarely requires much attention, in that the walls, when once divided, rapidly collapse, and this effectually checks further loss of blood ; but if the larger veins are involved, or if the walls are thickened and rigid, as in varix, a very considerable amount may be lost, the blood welling up in a dark, purplish stream from the wound, and rendering its arrest the more difficult from the fact that, except in veins of the largest size, there is no definite jet or gush to guide one to the wounded spot. Treatment of Venous Haemorrhage. —The same means to a large extent must be employed as for arterial haemorrhage, but it is less frequently required, since the smaller veins collapse naturally, and thus the bleeding stops. It is never advisable to occlude the whole circumference of a large vein if it can be avoided, since a puncture or tear can often be secured without seriously encroach- 16 242 A MANUAL OF SURGERY ing upon the calibre of the tube. In amputations it is usual to tie both the main artery and vein. Where it is difficult to reach a vein in order to tie it, the wound may be stuffed. The dangers of venous haemorrhage are fourfold : (i) The con- stitutional symptoms arising from the actual loss of blood, details of which have been given above ; (2) the thrombus which forms may become displaced as an embolus ; (3) septic infection of the thrombus lying in the mouth of the vessel may lead to pyaemia ; and (4) the entrance of air into veins, which, though rarely met with, is fraught with the most urgent danger to the patient. The air becomes churned up in the cavities of the right side of the heart, forming a spumous, frothy mixture amongst the columnar carneae, which the heart can only with difficulty eject ; thus the circulation is brought to a standstill in spite of forcible cardiac contractions, and the patient dies from anaemia of the lungs and brain. The Cause of the entry of air is usually a wound of some vein in what is known as the ' dangerous region ' of the neck or axilla, but it may occur in other positions. There is but little blood- pressure within the veins at any time, but during inspiration the movements of the thorax exercise an aspiratory or suction effect upon the blood in the veins of the neck, a most important element in the maintenance of the venous flow. Any condition which tends to prevent the collapsing of the walls of the veins, or brings about what is termed their canalization, predisposes to this accident. Thus they may be held open at spots where they pierce the deep fascia or the platysma ; if the coats are thick and rigid from inflammation, or surrounded by indurated tissue, or button-holed as by excision of a portion of the walls or division of a branch close to the main trunk, or if undue traction is exer- cised upon the pedicle of a tumour containing a wounded vein, then the orifice may remain patent, and air can be sucked in. If, however, the veins are very distended, and the intravenous pressure high, as is often seen in the operation of tracheotomy, then the wound of a vein, even in the dangerous area, usually results in loss of blood rather than entrance of air. Signs. — The entrance of air into a wounded vein is accompanied by a hissing, gurgling, or sucking sound, which is quite charac- teristic. A few bubbles of air may also be seen clinging about the aperture in the vessel. If only a small amount has entered, no bad results may follow ; but the usual effect of this accident is to produce sudden and severe faintness, and if the patient is con- scious, a feeling of dyspnoea and distress, which is partly cardiac in origin, partly due to obstruction to the flow of blood through the lungs. The pulse becomes rapid and almost imperceptible, the pupils widely dilated, and death usually follows, preceded perhaps by convulsions, although the fatal issue may be postponed for a few hours. If the patient survives, no after-effects remain. HEMORRHAGE 243 Treatment.— This accident can usually be avoided by dealing cautiously with all veins in operations about the neck. Should it occur, any fresh entrance must be at once checked by placing a finger over the bleeding point or pouring lotion into the wound. The vein should be secured by ligature as soon as possible. Com- pression of the chest has been recommended by some authorities in order to squeeze out the air that has entered ; but there is little chance of attaining this end. To combat the general symptoms, it is essential to maintain a good supply of blood to the brain. The head is lowered, and, if need be, the limbs raised and bandaged, or the abdominal aorta compressed. Stimulants and artificial respiration are used in order to maintain the heart's action and to overcome the pulmonary obstruction. Warmth and friction are also applied to the extremities. Capillary Haemorrhage. This is usually of little significance. It is characterized by a general oozing from the wounded surface, the blood trickling down to fill the cavity from the bottom. It is often very abun- dant from inflamed parts, and especially from fibro-cicatricial tissue, which prevents the closure of the vessel mouths. It can usually be arrested by a little pressure, or by the application of cold or hot water, by styptics, cauterization, or plugging. Methods of dealing with Haemorrhage from Special Sources. Carotid Artery. — Treatment is impossible unless the surgeon is on the spot, when both ends should be tied. Jugular Vein. — Tie, or stitch, if possible, without occluding the whole lumen. Secondary Branches of the Carotid. — It may be difficult to secure the divided ends of these vessels either in the neck or head, e.g., in a cut throat or a punc- tured wound of the pterygoid region. Under such circumstances, ligature of the external carotid between the superior thyroid and lingual has been recommended as more satisfactory than tying the common carotid, since the cerebral circulation is not thereby affected. Vertebral Artery. — The source of such bleeding may be difficult to ascertain, as it is scarcely possible to compress this vessel without also including the carotid ; and hence mistakes in diagnosis have often arisen. It may be feasible, however, to control the carotid alone by pinching it up by the fingers placed on either side of the sterno-mastoid, without interfering with the vertebral. Treatment must follow the usual course of cutting down and tying at the bleeding point, if possible. To do this the incision must be enlarged, or a new one made along the posterior border of the sterno-mastoid in order to define the transverse processes of the vertebrae. In the upper part of its course the vessel may be secured by clipping away a transverse process if necessary, due care being taken of the nerve roots ; otherwise, plugging of the vertebral canal or the use of styptics must be depended on. It is most essen- tial that the carotid should not be tied by mistake in these cases, as therebv more blood is directed to the vertebral trunk, and the bleeding is correspond- ingly increased. The Internal Mammary Artery rarely calls for treatment, since a punctured wound of this vessel is usually complicated with some graver mischief to heart, 16 — 2 244 A MANUAL OF SURGERY liver or lungs. If recognised, tie at the bleeding spot, possibly removing a costal cartilage to gain access. The vessel lies about \ inch outside the border of the sternum. Intercostal Haemorrhage usually results from penetrating wounds also in- volving the rib, and is not easily stopped, on account of the position of the vessels in the groove. Treatment. — Incise the periosteum longitudinally along the lower border of the rib, and detach it and the vessels from the groove ; or remove a portion of the bone, and thus expose the bleeding point ; or in some cases a suture passed round the rib a little above the injury has sufficed ; or again, pressure may be employed by pushing a piece of aseptic gauze, like a pocket, through the wound into the pleural cavity, and then stuffing it tightly with wool or strips of gauze, so that on pulling upon it the vessel may be effectually compressed. Wounds of the Vessels of the Extremities need treatment according to the principles enunciated above. Only one or two require special mention. Wounds of the Palmar Arches were formerly much more dreaded than they are at present, when thorough antisepsis and the use of the elastic tourniquet allow us to explore the depths of a wound without much danger or difficulty. The position of the wound will usually indicate whether the bleeding comes from the superficial or deep arch, but in case of doubt it is well to remember that pressure on the ulnar trunk mainly affects the superficial arch, whilst pres- sure on the radial will chiefly influence the deep. A wound of the superficial arch presents little trouble in treatment, as it can be readily secured by catch forceps and ligature ; but the deep arch is not so easily dealt with. It lies just over the bases of the metacarpal bones (Fig. 62, d), and to expose it the wound must be freely enlarged by a longitudinal incision, and the tendons turned on one side or separated. It may be possible to secure the vessel by forcipressure forceps, and these may be left on for twenty-four hours if a ligature cannot be applied. Of course the strictest asepsis is needful in such cases, and passive movement of the fingers must be early undertaken, in order to prevent troublesome adhesions. Failing such means, or in septic wounds, a modification of the old graduated compress may be employed ; the wound is care- fully and thoroughly plugged with gauze, and over this the fingers are firmly bandaged. The patient is kept in bed for a few days, and the arm elevated. Pressure on the main vessels above is scarcely necessary if the compress is accurately applied. The bandages may be relaxed at the end of twenty-four hours, but the deep dressing should, if possible, not be touched for three or four days. If, in spite of this, bleeding recurs, the main vessel or vessels of the limb must be tied. Ligature of the ulnar and radial at the wrist is generally insufficient to control it, as there is often a communicating branch of some size passing from the anterior interosseous to the deep arch, and hence it may be needful to secure the brachial artery, ascertaining first, how- ever, by pressure that such would be efficacious ; for occasionally there is a high division of the brachial, or a vas aberrans may exist, which would compel the surgeon to tie the third part of the axillary. Bleeding from the Plantar Arch must be conducted on exactly similar lines. The Gluteal, Sciatic, or Pudic arteries may be wounded by stabs in the buttock. Treatment. — Enlarge the wound in the direction of the fibres of the gluteus maximus, i.e., downwards and outwards, and secure the bleeding Fig. 62. — Hand, to show position of Palmar Arches. A, Radial artery ; B, Ulnar artery ; C, Superficial arch ; D, Deep arch. HEMORRHAGE 245 vessel. The gluteal trunk emerges from the pelvis at the junction of the middle and inner thirds of a line from the posterior superior iliac spine to the great trochanter ; the pudic crosses the ischial spine at the junction of the middle and lower thirds of a line from the posterior superior iliac spine to the tuber ischii. The sciatic emerges from the pelvis just above and a little external to the latter spot. The pudic may also be divided in the perineum by a penetrating wound. Failing ligature of any of these arteries at the seat of bleeding, the internal iliac may need to be secured. Haemophilia. By haemophilia, or the hemorrhagic diathesis, is meant a congenital and hereditary disease characterized by a tendency to persistent and uncon- trollable bleeding from slight wounds, whether open or subcutaneous. This condition is often associated with extravasation of blood into the joints, and certain consecutive phenomena (Chap. XX.). The family history is always interesting, the disease being usually transmitted through the females to the males of a succeeding generation, whilst the former often escape entirely. The pathological cause of this affection has not yet been ascertained, no change in the vessels or constitution of the blood having been discovered. Unless haemorrhage is actually occurring, nothing abnormal is noticed, but any injury is sure to be followed by excessive bleeding ; spontaneous sub- cutaneous ecchymoses frequently occur, as also bleeding from the mucous membranes. Hence no operations must be undertaken on such patients unless absolutely urgent, even such a small matter as the extraction of a tooth having proved fatal. The Treatment of haemophilia should be directed more to correcting the constitutional defect than to pursuing the usual practice in dealing with haemorrhage. The application or administration of haemostatics, and sub- stances which tend to promote coagulation and the formation of fibrin, should be resorted to. Calcium chloride, 1 drachm to i pint of water, given by enema, or 30 grs. by the mouth, repeated several times a day, has been recommended, whilst fibrin ferment, suprarenal extract, and cocaine should be employed locally. Position and pressure are attended to, and in severe cases the actual cautery may prove useful, or the prolonged application of cold. CHAPTER X. INJURIES AND DISEASES OF ARTERIES— ANEURISM- LIGATURE OF ARTERIES. Injuries of Arteries. Contusion of an artery is the result of violence applied directly to the vessel wall. The effects vary with the severity of the injury and with the condition of the arterial tunics. If atheroma or calcification exists, thrombosis often follows slight injuries, and dry or senile gangrene may ensue ; but in healthy arteries a good deal of violence is needed to produce such an effect, as their natural elasticity enables them to yield or slip aside, and thus the consequences are usually insignificant. Rupture or Laceration may follow more severe blows or strains, weakness or disease of the arterial wall predisposing to it. It occasionally results from attempts to reduce old-standing disloca- tions, or to break down intra-articular adhesions when the vessel has become fixed in some abnormal position. If the rupture is partial, the inner and middle coats are usually torn through, and by projecting into the lumen of the vessel constitute a valve which prevents the passage of blood, and leads to subsequent thrombosis and occlusion. In other cases, where the injury to the coats is slight, a thrombus may form, which leads to obliteration ; or, if the lesion is limited to one side, the clot may become organized over that spot, narrowing, but not interfering with the lumen of the vessel, and leaving an area of weakness from which an aneurism may subsequently develop. Again, when complicated with a septic wound, an ulcerative form of peri-arteritis may ensue, giving rise later on to secondary haemorrhage. It is also stated that the adventitia is occasionally torn without injury to the tunica intima, and that an aneurism may result from a protrusion of the latter coat through the wound in the former ; such an occurrence must be exceedingly rare. A dissecting aneurism (p. 259) may also result under special circumstances from such an accident. Complete Rupture of an artery often leads to but little haemor- rhage in a severe lacerated wound, such as is produced when a INJURIES AND DISEASES OF ARTERIES 247 limb is torn off: the inner and middle coats give way at a higher level than the adventitia, and curl up within it, whilst the outer coat and sheath contract over them, and thus prevent bleeding. If, however, the artery is ruptured in a subcutaneous injury, such as a fracture or dislocation, extensive extravasation often ensues, constituting the condition badly termed a Diffuse Traumatic Aneurism. The objection to this name lies in the fact that there is no true sac wall as in an aneurism, the only boundary con- sisting of an ill-defined mass, partly coagulum, partly inflammatory exudation, and in part thickened and infiltrated tissues. A similar condition may ensue from a punctured wound dividing a vessel, where the track leading to it is valvular or becomes closed by clot or some external application. Symptoms. — The patient usually feels a snap, as though some- thing had given way, accompanied by a sudden pain, localized to the part injured, and often shooting down the limb in the line of the vessel. These are succeeded by the following phenomena : (a) Locally, the formation of a diffuse, rapidly increasing swelling, the skin over which is at first normal, but soon becomes dis- tended and bluish, and finally bright red and cedematous, when the tumour is threatening to give way. There is no increased local heat except in the later stages. Distinct pulsation is usually present, and some amount of bruit, synchronous with the heart's action, although these subsequently become less obvious. (b) Distally, diminished sensibility in the limb quickly follows, together with loss of pulsation in the vessels and a fall of temperature. It lies more or less useless and flaccid, and in colour is either white and blanched, or may be congested and cedematous if the extravasated blood presses upon the venous trunks, (c) Generally, the signs of haemorrhage and shock manifest themselves in varying degree, according to the amount of blood lost and the character of the violence. Results. — (1) The swelling may increase steadily in size until the skin becomes so distended as to rupture or slough, and then, if help is not at hand, the patient dies of haemorrhage. Occasionally the bleeding continues into an internal cavity, or into the tissues of a limb, to such an extent as to cause death without any external loss of blood. (2) Suppuration, accompanied by the general signs of fever, may result from auto-infection, or from the entrance of bacteria through the small valve-like wound. The whole swelling becomes red, hot, cedematous, and excessively tender, looking like a large abscess. Rupture and external haemorrhage will probably conclude the case if surgical assistance cannot be obtained. (3) The pressure of the extravasated blood upon the veins or on the arteries needed for the collateral circulation may determine gangrene of the extremity, which is almost always of the moist type. (4) The process may become more or less limited after a time by coagulation occurring in the divided mouth of the vessel, which is 248 A MANUAL OF SURGERY thus occluded. Collateral circulation may be established, and thereby the health and vitality of the limb are maintained, whilst the blood-clot is absorbed or organized. The Treatment is necessarily the same as for a divided artery communicating with an open wound, viz., to cut down and tie both ends. The circulation is first temporarily arrested by an elastic tourniquet, a free incision made, and all coagula removed. The bleeding points are then sought for and tied, the tourniquet being relaxed to allow them to become evident. If the distal end cannot be found, the wound is not closed, but should be stuffed with gauze, and allowed to granulate, a tourniquet being kept loosely about the limb ready to be tightened at any moment, if necessary. When suppuration is threatening, the same plan must be adopted, viz., free incision and tying the ends of the vessel if they can be found ; but in cases where from the cedematous and unhealthy state of the surrounding parts this is impracticable, it will be necessary either to tie the main trunk on the cardiac side of the rupture, or to trust to the pressure of a graduated compress. If gangrene is imminent, or if secondary haemorrhage occurs, amputation is the only resource. Penetrating Wounds of arteries, if completely dividing the vessel, are always followed by haemorrhage, although the blood may be unable to escape if the wound in the skin is small or valvular, or if the opening is closed by blood-clot or dressing ; under these circumstances, the signs due to subcutaneous rupture of a vessel are produced. The amount of bleeding in open wounds varies according to the character, direction, and extent of the lesion, and with the size of the vessel. If a large artery is cleanly cut across, the bleeding is copious, whilst from a small vessel it soon ceases, owing to the contraction and retraction of the coats. When an artery is buttonholed — i.e., when a small segment of the wall is cut through — the haemorrhage is often continuous and prolonged, since retraction cannot take place. The treatment of this condition consists in completing the division of the injured trunk, if it is a small one, thus allowing of contraction and re- traction, or, if the vessel is of large size, in tying it above and below the opening, and dividing it between the ligatures. If the wound is in the long axis of the vessel, it gapes but little, and the loss of blood is often slight, whilst if transverse or oblique, both contraction and retraction tend to increase the size of the opening, rendering it more nearly circular, and therefore the haemorrhage in such cases is considerable. If a small artery is divided close to its origin from a large main trunk, the blood escapes with a jet, the strength of which is proportionate to the blood-pressure in the main trunk, and not to the size of the vessel divided. In such a case the main trunk must be tied above and below the wound, and divided INJURIES AND DISEASES OF ARTERIES 249 between the ligatures, and the distal end of the divided branch also secured. A good many attempts have been made of late to effect the union of wounds in the walls of arteries without causing their obliteration, and with some success. Small longitudinal wounds may certainly be sutured, the stitches being of the finest silk and applied so that the edges of the tunica intima are brought accur- ately into apposition ; Heidenhain reports a case where a wound 1-5 cms. long in the axillary artery was successfully sutured in this way. End-to-end union of a divided artery has also been obtained in one case," the upper end being invaginated into the lower ; such a procedure can, however, only be required under very exceptional circumstances. In punctured wounds of arteries the size of the penetrating body is all-important. A vessel may be traversed by a needle without haemorrhage or any subsequent ill effect, but a larger puncture results in extravasation. If it ceases after a time, the blood-clot is absorbed, and the wound in the vessel closed by a cicatrix, which may subsequently yield to the blood-pressure, and give rise to a circumscribed aneurism. This occurrence is not unfrequent in the neighbourhood of the wrist from glass wounds, involving the radial or ulnar trunks, and hence is not uncommon among window-cleaners or mineral-water bottlers. Arterio-Venous Wounds are not so frequent in the present day as formerly, when venesection was in vogue. They follow penetrating wounds which involve an artery and vein lying in close contact, e.g., at the bend of the elbow between the median basilic vein and the brachial artery, in the neck between the internal jugular and carotid, in the groin between the femoral vessels, and occasionally in the orbit. Two conditions may result. An Aneurismal Varix is produced by a direct communication between an artery and a vein, no dilated passage intervening between the vessels (Fig. 63, A). The venous walls, unfitted to withstand arterial pressure, are thereby dilated and rendered varicose. A pulsating venous tumour results, the dilatation extending for a variable distance above and below the opening, and at each beat of the heart a loud whizzing sound can be heard, likened by some authors to that caused by an imprisoned bluebottle buzzing in a thin paper bag. Treatment. — Nothing is usually required beyond the application of an elastic bandage or support to prevent further enlargement. Should pain or inconvenience arise, the artery should be secured above and below the abnormal communication with the vein. Occasionally the latter is so distended that it has to be removed before the artery can be reached. This operation should not be undertaken in the neck for the carotid-jugular varix unless * J. B. Murphy, Medical Record, January 16, 1897. 250 A MANUAL OF SURGERY absolutely essential. In the orbit electrolysis may be used with advantage. A Varicose Aneurism, though brought about by the same cause, differs from the above in that an aneurismal sac exists between the artery and the dilated vein (Fig. 63, B). It is produced when the vessels are placed at a short distance from each other, or when extravasation of blood has separated them. The aneurism is of the false type, its walls being composed entirely of newly- formed organized clot and cicatricial tissue ; it is almost certain to become diffuse. The physical signs are similar to those of aneurismal varix, except that the aneurism can be sometimes A B Fig. 63. — Diagrams of Aneurismal Varix and Varicose Aneurism. A, Artery; V, Vein; AN, Aneurism. detected by palpation, whilst a soft bruit may be heard over it, and the distension of the veins is not quite so marked. Surgical Treatment is always required in these cases. Simple ligature of the artery above and below the abnormal communi- cation will sometimes suffice, allowing the blood in the sac to coagulate ; the veins will subsequently diminish in size, when the arterial blood-pressure is removed. Occasionally, however, the vein overlaps the artery, and has to be tied and removed before the sac of the aneurism is reached ; it is then better to excise the sac and tie the artery above and below. In the less urgent cases digital pressure to the artery above the sac is some- times successful. Inflammation of Arteries. Various forms of inflammation of the arterial wall are met with, which are usually named from the cause producing them — Traumatic, Infective, or Embolic arteritis. The terms Endarteritis and Periarteritis are used to distinguish inflammatory conditions which respectively start from the tunica intima, or reach the vessel from without ; in both cases, however, the middle coat is generally INJURIES AND DISEASES OF ARTERIES 251 involved, and the process may even finally spread beyond it, so that the whole thickness of the arterial wall is attacked. 1. Traumatic or Plastic Arteritis is the result of some injury, such as total or partial division of the vessel, laceration, bruising, etc. The phenomena are merely those of repair, resulting in occlusion of the vessel, viz., congestion of and exudation into the vessel walls from the vasa vasorum, together with proliferation of the tunica intima ; they have been already described at p. 227. 2. Infective Arteritis is a condition in which the arterial wall becomes invaded and softened by bacteria. It frequently results from inflammation advancing inwards from the exterior (peri- arteritis), and is usually seen in connection with septic wounds and spreading ulceration. The vasa vasorum are dilated, and an exudation of leucocytes occurs, as a result of the bacterial in- vasion ; the peptonizing action of the toxins thereby produced leads to softening of the vessel walls, the fibres of which lose their cohesion with each other. Finally, their resisting power may be so impaired that they yield before the blood-pressure and cause haemorrhage, unless thrombosis has previously sealed the vessel. In the smaller arteries this is usually the case, but in those larger than the radial there is considerable danger of bleeding, especially if the irritation is confined to one side of the vessel. Secondary haemorrhage from arteries tied in their continuity is generally due to this cause, as also bleeding from phthisical cavities, the vessels having previously lost the support of surrounding tissues, and being more or less dilated or aneurismal. Acute abscesses, septic ligatures, and malignant tumours may weaken an arterial wall and lead to haemorrhage, whilst the infective agent sometimes reaches the walls from within, as from an infective embolus. 3. Embolic Arteritis. — When a vessel is blocked by a simple embolus, obliteration as a result of a simple plastic arteritis is the usual consequence. If the embolus contains some irritating or infective material, as in a case of infective endocarditis or pyaemia, an abscess may result ; but if the irritant is less intense, the process may stop shore of suppuration, and yet an aneurismal dilatation of the softened wall takes place. The latter process is the most common cause of spontaneous aneurism in children. 4. Acute Endarteritis is met with rather as a pathological curiosity than as a condition of any clinical import. It is usually associated with acute endocarditis, however produced, or may accompany some of the chronic forms described below. It is evidenced by the presence on the inner aspect of the vessel of more or less raised patches, somewhat pinkish and gelatinous in appearance, soft and elastic in consistency, and although the polish is lost, the endothelium is usually intact. It is found in the aorta, or in smaller vessels, especially near inflamed wounds. 5. Chronic Endarteritis is an exceedingly common affection, and the following forms may be described : 252 A MANUAL OF SURGERY (a) Simple Chronic Endarteritis, resulting in Atheroma (Gr. d#?//»7, 'gruel' or 'pap'). This condition is constantly found in elderly people, but especially in drinkers and those who have suffered from chronic Bright's disease, gout, or syphilis ; it arises from continual strain and increased blood-pressure, and hence often starts in the convexity of the aortic arch, at the spot where the impact of the blood-stream is most felt as it is ejected from the ventricle, or in places where a vessel passes over or around some bony projection, or at the bifurcation of a main artery, or where a large branch is given off, thus causing a sudden decrease Fig. 64. — Section of Atheromatous Cerebral Artery, x 50. (Ziegler.) a, Intima considerably thickened; b, bounding elastic lamella of intima ; c, media; d, adventitia ; e, necrosed denucleated tissue with masses of fatty detritus ; /, and f lt detritus with cholesterine tablets ; g, intima infiltrated with leucocytes; h, infiltration of adventitia with leucocytes. in its lumen. It is rarely found in the smaller arteries, except those of the heart or brain. The pathological phenomena consist at first of a proliferation of the deeper parts of the tunica intima, giving rise to opaque, milky-looking, non-vascular patches (Fig. 64, g), which may organize into fibroid tissue, or undergo fatty degeneration (e and /). They are arranged longitudinally or around the mouths of large branches. The tunica media is more or less involved in the process, and the adventitia is often thickened externally. As soon as the fatty changes have commenced, the patches become INJURIES AND DISEASES OF ARTERIES 253 yellowish in colour, somewhat elevated from the inner surface, and irregular in outline ; they are small at first, but increase in size, and coalesce one with another. The contents are now fluid or cheesy in consistency, constituting the so-called ' atheromatous abscess,' although no true pus exists, the pultaceous material consisting of fatty granules and debris, with oil globules and plates of cholesterine (Fig. 64, /j). It maybe absorbed entirely, leaving a weakened spot in the wall of the vessel, from which an aneurism may arise ; or the tunica intima may give way over it, allowing the contents to be swept into the general circulation, where it probably does no harm, and the raw surface left behind Fig. 65. — Syphilitic Arteritis, x 150. (Ziegler ) a, Intima greatly thickened by newly-formed fibro-cellular tissue ; b, fenes- trated elastic lamina of Henle ; c, muscle fibres of media, infiltrated towards the left ; d, adventitia thickened by cell infiltration and hyperplasia. is known as an ' atheromatous ulcer.' The outer coat has by this time become thickened, and hence no immediate ill result follows the breach in the inner coats, although subsequently dilatation may take place, even though cicatrization of the ulcer has occurred. Again, the blood may find its way through the open- ing into the substance of the wall and strip up the inner from the outer layers, constituting a ' dissecting aneurism ' ; or a localized thrombus may form, causing occlusion of the vessel. Not uncommonly the cheesy contents of the abscess become inspissated, and later on infiltrated with lime salts, resulting in the formation of calcareous plates, which are either covered with endothelium, or exposed to the blood stream, and hence may cause 254 A MANUAL OF SURGERY thrombosis, or become detached as an embolus, or the blood may get in under the plate and form a dissecting aneurism. A condition of endarteritis evidenced by proliferation of the tunica intima is always met with in chronically inflamed tissues, as also in diabetes ; such does not, however, run on to atheroma. (b) Chronic Syphilitic Endarteritis is chiefly met with in the tertiary stage of the disease, and is characterized by an over- growth of the tunica intima (Fig. 65, a), which is at first limited by Henle's elastic lamina (b), but is subsequently associated with infiltration of the media (c), and much more so of the adven- titia (d). The change occurs in the smaller arteries, especially those of the brain or kidneys, or in the neighbourhood of gummata, and but rarely in the larger vessels, although a considerable per- centage of individuals affected with internal aneurism have suffered from syphilis. It differs from simple atheroma (1) in attacking small arteries ; (2) in affecting the whole circumfer- ence of the vessel, and not merely patches ; (3) the newly- formed tissue becomes vascular, and does not undergo fatty degeneration ; and (4) it leads to narrowing or occlusion of the vessel rather than to weakening and dilatation. When involving the cerebral arteries, various forms of monoplegia, or even hemi- plegia, may result. (c) It is still more or less an open question whether the so- called Endarteritis obliterans or proliferans is truly syphilitic or not. In some cases a syphilitic history has been present, but in other marked instances it has been entirely absent. The main arteries are gradually obliterated in persons apparently sound in health, as a result of which the peripheral parts become anaemic, diminished in vitality, or even gangrenous. The tunica intima is converted into a thickened and vascular mass, which narrows and finally occludes the lumen. This disease, which is by no means common, is associated with considerable local pain. (d) Chronic Tuberculous Endarteritis is met with as a prolifera- tion of the tunica intima, with or without thickening of the adventitia, in all places in which tubercle is actively developing ; in fact, tubercles are usually formed around arterioles, and as the mass grows the vessel is slowly occluded and replaced by the typical anatomical structure of the miliary tubercle. The tuber- culous endarteritis may, however, spread widely beyond the focus of the mischief, and in almost any portion of pulpy granulation tissue this change can be seen. Degeneration of Arteries. Fatty Degeneration occurs independently of atheroma, involving merely the tunica intima, and manifesting itself in small patches, yellowish in colour and stellate in shape. As a rule, it is of but little significance ; but occasionally the infiltration is deeper, and INJURIES AND DISEASES OF ARTERIES 255 the tunica intima gives way, causing the so-called fatty evasion, and then an aneurism, possibly of the dissecting type, may arise. The most usual seat of this trouble is the aorta. Primary Calcareous Degeneration (Fig. 66) is chiefly met with in the smaller arteries of the extremities. It occurs in elderly people at the same time of life as the calcification of cartilages, etc., and commences by the deposit of lime salts in the muscular fibres of the tunica media, constituting a series of calcareous rings which transform the elastic expansile vessels into rigid tubes like gas-pipes, through which can alone pass a fixed and unchangeable minimal supply of blood. Fig. 66. -Primary Calcareous Degeneration of Arteries. College of Surgeons' Museum.) (From The affected limb passes into a condition of chronic anaemia and impaired nutrition, resulting in coldness of the feet or hands, cramps and spasms of muscles, sensations of pins and needles, etc. The endothelium is not removed except in the later stages, and then thrombosis may be produced, or a similar result may arise from the lodgment of an embolus. Senile gangrene is a common termination of such arterial changes. From the general rigidity of the vessel, and the method of deposit of the lime-salts, it follows that aneurism is not likely to occur. Amyloid Degeneration of the viscera commences in the arterial walls, but is described elsewhere (p. 53). The Effects of Arterial Inflammation and Degeneration are both local and peripheral. Locally, Thrombosis may be produced whenever the lining endothelium is removed and a raw surface 256 A MANUAL OF SURGERY exposed, upon which fibrin can collect. Under this fibrinous coating repair is often effected without further complication ; but if the blood-stream is retarded, or the lumen of the tube narrowed, complete thrombosis is likely to follow, the clot extending some distance up or down the vessel, or even from a branch into the main trunk, which may be blocked by this means. Aneurism is also a result of any weakening of the arterial tunics. Oblitera- tion of the artery may follow, either in consequence of thrombosis, or from excessive proliferation of the tunica intima (as in syphilitic or tuberculous disease), or from gradually increasing pressure from without. Lastly, Spontaneous Rupture is another local effect occasionally met with. Peripherally, defective blood-supply and consequent lowered vitality are the most marked results of arterial disease, leading to various forms of ulceration and gangrene. Thus, senile gan- grene is due to calcareous changes in the arteries, fatty degenera- tion of the heart follows atheroma of the coronary arteries, whilst softening of the brain may ensue from various affections of the cerebral vessels. Similar results may also arise from emboli detached from areas of local disease. Aneurism. An Aneurism is a tumour filled with blood communicating with the interior of an artery, and due to dilatation of part or the whole of the vessel walls. Causes. — Aneurisms have been divided into the spontaneous and the traumatic, the distinction between them being that in the former the coats of the artery are primarily diseased, whereas in the latter they may be previously healthy. However, it must not be forgotten that persons with diseased arteries are just as liable to injury as, and even more so than, those with healthy vessels, and thus no strict line of separation can be drawn between the two forms. The causes of aneurism may be conveniently grouped under two headings : i. Changes in the Vessel Walls, by which their resistance to the intravascular pressure is diminished. Many varieties of disease, e.g., atheroma, whether starting from within or without, predispose to aneurismal dilatation, especially if occurring in syphilitic or gouty men about middle life, in whom, although the arterial tunics may be weakened, the power of the heart and the resulting blood-pressure are by no means diminished. Calcifica- tion, on the other hand, is antagonistic to aneurismal dilatation. Any injury, a contusion, a penetrating wound, or a strain, may so interfere with the integrity of the vascular coats as to result in aneurism, and, indeed, a cicatrix in an arterial wall must always be looked on as a weak spot predisposing to dilatation. The lodgment of an embolus in the smaller arteries is stated ANEURISM 257 to be one of the most common causes of spontaneous dilatation of these vessels in the brain and extremities of young people. 2. Increase in the Blood-Pressure is another factor, especially when due to heavy strain or exertion, which leads to irregular excitement and increased action of the heart. Steady laborious employment, such as is seen amongst artisans and mechanics, or regular exercise, does not appear to predispose to this condition ; but irregular intermittent efforts, in which for the time being every power is strained to its utmost, are very liable to determine its occurrence. A day's exertion in the hunting or shooting field by an elderly man, accustomed to sedentary occupations, is often the cause of some vascular lesion, such as aneurism, apoplexy, etc. Hence aneurisms are more frequently seen amongst men than in women, in the proportion of seven to one; whilst they are much more common among the dwellers in Northern climates than in the more lethargic and ease-loving inhabitants of the South. The energy and activity of the Anglo-Saxon race espec- ially predispose them to this disease. Structure of an Aneurism. — Formerly much stress was placed on the terms true and false, the word ' true ' meaning that all the coats of the vessel were present, whilst the ' false ' were those in which the sac wall comprised little or none of the original arterial tunics. This distinction is of comparatively little value, since no aneurism which has attained to any size is in reality true. The sac consists more or less evidently of a distension of all or part of the original walls of the vessel whilst it is small ; but as the aneurism increases, the original structure is replaced by a mass of newly-formed fibrous tissue, due to a condensation and matting together of the surrounding structures, with or without an internal lining of laminated fibrin deposited on parts where the endothelium of the tunica intima has disappeared. The contents of the sac depend on the character, age and size of the aneurism. Whilst still small and with a complete endothelial lining, it merely contains fluid blood, the amount of which varies with each beat of the heart ; but as the tumour grows, and especially if of the sacculated type, the whole or part of the interior becomes lined with a deposit of fibrin, upon which, again, other layers form, until possibly in rare cases the entire cavity is filled, and a spontaneous cure results. The oldest laminae are dry and yellowish-white in colour (the so-called active clot of Broca) ; those more recently deposited are softer and more reddish, whilst the last formed is merely like ordinary blood coagulum (the passive clot of Broca). No single lamina covers the whole area, but layer is arranged over layer (Fig. 67) in such a manner that the oldest and necessarily the smallest laminae are nearest to the sac wall. Three chief varieties of aneurism have been described : ■ the fusiform, sacculated, and dissecting. 1 . The Fusiform Aneurism (Fig. 68, A) is one in which the whole r 7 258 A MANUAL OF SURGERY lumen of the vessel is more or less equally expanded, so that the swelling is tubular in character. It is due rather to a general increase of blood-pressure, or to a widely extended disease of the arterial walls, than to any localized lesion or injury, and hence is more commonly met with in the larger internal vessels than in those of the extremities. The tunica intima is usually represented throughout the whole extent of the sac, but is thickened and atheromatous in patches, the margins and surfaces of calcareous plates being indicated by flocculi of fibrin, which are attached to them, although no regular laminated deposit is present. The Fig. 67. — Sacculated Aneurism. (Museum of Royal College of Surgeons.) The small mouth of the saccule is clearly seen, and the cavity is nearly filled with laminated clot. tunica media is stretched, atrophied, and in the later stages practically non-existent, whilst the adventitia is much thickened by inflammatory new formation and by incorporation with the surrounding tissues. The progress of fusiform aneurisms is generally slow, so that in some situations, e.g., the thorax, they may attain enormous dimensions, and cause grave symptoms by their pressure. A natural cure is almost impossible, and hence, if unchecked by treatment, a fatal termination is caused by rupture or by implication of important neighbouring structures. Frequently one portion of the aneurysmal wall yields more ANEURISM 259 than another, and thus to the fusiform swelling is superadded a localized sacculation, which by its rapid increase in size may quickly destroy life 2. A Sacculated Aneurism (Figs. 67 and 68, B) is due to the yielding of some weak patch in the vessel wall which does not involve the whole circumference, or, as just mentioned, it may spring from a fusiform aneurism. It communicates with the interior of the artery by an opening of variable size. All trau- matic aneurisms are of this type, whether they are due to the yielding of a cicatrix, or to the partial division of the coats of the vessel, and hence they are most commonly met with in the ex- tremities. It is possible that in some very early specimens all Fig. 68. — Diagrams of Fusiform, Sacculated, and Dissecting Aneurisms. In the first the walls are expanded, but more or less normal in texture ; in the sacculated, the normal structure of the arterial wall ceases abruptly at the commencement of the saccule ; in the dissecting, the arterial wall is split into two lamellae. The interrupted fine line is supposed to represent the intima ; the continuous dark line, the media ; and the continuous fine line, the adventitia. the vascular tunics may be present, but such an occurrence must be extremely rare. Generally one can trace the inner and middle coats to the mouth of the saccule, and there they are suddenly lost, the wall being constituted by a mass of ribro- cicatricial tissue, upon which laminated fibrin readily forms, thus increasing its thickness and power of resistance. Their progress is, however, much more rapid than that of the fusiform, and they generally rupture or become diffuse, although occasionally a natural cure results. The blood as it enters the sac impinges against the wall furthest removed from the heart, and thence eddies back in circles, coagulation being thereby favoured. 3. A Dissecting Aneurism (Fig. 68, C) is one in which the blood 17 — 2 260 A MANUAL OF SURGERY forms a cavity within the wall of the vessel by stripping up the inner from the outer half, the line of cleavage being within the middle coat, half going with the adventitia, half with the intima. It is usually the result of extensively diffused atheroma. The blood thus driven into a cul-de-sac may remain limited to this cavity for some time, or it may find its way outwards, and become diffused, or burst back through another atheromatous spot into the interior of the vessel. The condition occurs chiefly in the thoracic aorta, but cannot be recognised ante-mortem. Symptoms and signs of a Circumscribed Aneurism. — These may be divided into two groups : the intrinsic and extrinsic. Intrinsic Signs. — A tumour, pulsating synchronously with the heart's beat, is present in the course of a vessel. The pulsations are distensile or expansile in character, i.e., the whole tumour increases in size at each systole, and that evenly in all directions, so that if the tumour is lightly grasped in any position the fingers are separated. If the supplying vessel is compressed on the proximal side, the pulsation ceases, and the tumour diminishes in size and becomes softer ; this is more marked in fusiform than in sacculated aneurisms. The application of pressure to the sac itself, whilst the afferent trunk is compressed above, will still further diminish its size. On removing the pressure, the swelling regains its old dimensions in a certain definite number of beats, usually not more than two or three. Pressure on the distal side of the sac makes it more tense and the pulsation more marked, unless such compression is very prolonged. On auscultating the tumour, a bruit of variable character may be heard. Usually it is loud, harsh, and systolic, but sometimes quiet and musical. It is occasionally double in some forms of sacculated aneurism, and in the aorta when regurgitation through the aortic valves is also present. The bruit is loudest and most rasping in the fusiform variety, and may be absent in the sacculated form, where the mouth is small and the cavity nearly full of clot. Great dis- tension of the sac is unfavourable to the production of the bruit. The Extrinsic Signs of aneurism are those occurring in neigh- bouring or distal structures from its constantly increasing size and pressure, and the interference produced by it with the circulation. The pulse in the vessels below is diminished and delayed, its diminution being caused partly by the obstruction experienced, but also in some cases by the pressure of the sac upon the trunk above or below the tumour. The delay is due to the interference with the transmission of the heart's impulse by the intervention of the aneurismal sac. The dicrotic notch is usually absent. The smaller vessels engaged in establishing collateral circulation may be compressed, and thus the vitality of the limb considerably impaired. Pressure on the accompanying vein or veins results in diminution of their calibre, and possibly a localized thrombosis, together with congestion and cedema distally, ANEURISM 261 whilst gangrene may be the final outcome if the case is not efficiently treated. Compression of nerves occasions neuralgia, spasm, or paralysis. Muscles are displaced, expanded, and attenu- ated ; bones may be eroded, as evidenced by a deep, constant, boring pain, and even spontaneous fracture may ensue ; whilst joints are encroached upon and disorganized. Tubes, such as the trachea or oesophagus, are often injuriously constricted and laid open by ulceration. It is an interesting fact to note that resisting tissues, like bone, are much more liable to be eroded than elastic, yielding structures, such as cartilage, and in cases where the vertebral column is encroached upon by an abdominal or thoracic aneurism, the bones always manifest greater destructive changes than the intervertebral discs. The increased difficulty in propelling the blood through the sac usually induces a certain amount of compensatory hyper- trophy of the heart. Emboli consisting of fragments of fibrin occasionally become detached, and lead either to a spontaneous cure, or to gangrene of the parts supplied by the vessel, or to death if the brain is involved. Gangrene may also be induced as a result of the diminished blood supply to peripheral parts, especially if associated with interference with the venous return. It is usually of the dry type, involving merely one or two fingers or toes ; but when attacking more fleshy parts, or if due to venous congestion, it is moist in character. The Differential Diagnosis of a circumscribed aneurism is not difficult, if due weight is given to the above symptoms and signs, but the following conditions may simulate it somewhat closely : 1. A tumour or chronic abscess situated near an artery, and deriving transmitted pulsation from it, is recognised by the impulse being merely heaving in character, and not expansile ; by the pulsation ceasing entirely if the tumour is lifted from the vessel, or allowed to fall away from it by assuming a suitable position ; by the size of the tumour not diminishing if the pulsation is stopped by pressure on the vessel above ; and by the fact that after stoppage of the pulsation the first beat is equal to the subsequent ones, whereas in an aneurism it almost always requires more than one beat to re-establish the strength and force of the impulse. More- over, the pulse below is not affected in the same way or to the same extent as when an aneurism is present. 2. A pulsating sarcoma or navus is known by being rarely limited exactly to the line of the artery, pulsation being present in situations where an aneurismal dilatation could not be felt, and being less forcible and regular in its character. The consistency of the swelling is more variable, and pressure over the afferent trunk does not diminish its size to any marked extent. Moreover, a sarcoma is usually more adherent to the deeper structures, and its limits are not so accurately defined. 3. The pain caused by an aneurism may lead it to be mistaken for rheumatism or neuralgia (e.g., for sciatica 262 A MANUAL OF SURGERY in popliteal aneurism), and in every case of obstinate pain of this kind the arteries should always be carefully examined with the intention of eliminating such a possible cause of the trouble. Natural Terminations and Results. — i. Spontaneous Cure, though of unusual occurrence, may arise in sacculated aneurisms from a variety of circumstances, and is a well-recognised phenomenon. (a) It may be due to the gradual deposit within the sac of fibrin, which, in the first place, limits the expansion and extension of the aneurism, but may finally increase to such an extent as to cause obliteration of its cavity. Such a termination can only occur in saccules with small mouths, and that also in vessels of the second magnitude, hardly ever in the aorta or larger trunks, the impetus of the blood stream being too great to permit of the necessary deposit of fibrin, (b) It may arise as the result of the sudden coagulation of all the blood in the sac from the stoppage of the circulation, owing to the lodgment of an embolus either at the mouth of the aneurism or in the trunk immediately below, (c) The aneurism may become so large as to compress the main vessel, either going to or coming from it, thus bringing about its own cure, (d) Again, if the sac becomes inflamed, consolidation may occur with or without suppuration, although the latter process, as will be seen anon, is attended with serious danger to life and limb. In the non-inflammatory conditions the sac becomes more and more firm, the pulsation less forcible and distinct, the bruit diminishes, and finally consolidation is effected, a firm fibroid tumour alone remaining, which gradually shrinks, whilst the collateral circulation is opened up so as to supply the limb below. It is sometimes by no means easy to recognise the fibroid mass resulting from the spontaneous consolidation of an aneurism, and in making a diagnosis the history has mainly to be depended on. The existence of a tumour in the line of an artery, the probable occlusion of the main trunk, and the fact that the circulation is carried on by means of collateral branches, are the chief points which can be ascertained by a physical examination. 2. Diffusion and Rupture result from yielding of the walls of an aneurism, as an outcome of some mechanical injury or from simple over-distension. When an internal aneurism gives way, the patient usually experiences a sensation of pain in the part, and becomes pale, cold, and faint, possibly dying within a few minutes or, at most, hours ; or there may be a sudden gush of blood from the mouth if the trachea or oesophagus has been opened. Sometimes internal aneurisms leak slowly, and the final stage lasts some days. When an external aneurism yields, it may do so slowly or quickly. If the blood becomes effused slowly (constituting what is sometimes called a leaking aneurism), the tumour gradually increases in size, and its outline is less clearly limited ; the pulsa- tion diminishes in force and distinctness, and the signs of pressure ANEURISM 263 upon the veins or nerves become more urgent, until, perhaps, gangrene supervenes. If the aneurism ruptures suddenly the patient experiences severe pain in the part, which becomes tense, swollen, and brawny ; all pulsation ceases, both in the aneurism and below it, and gangrene of the limb follows, or even death from syncope, arising from the amount of blood extravasated, either externally if the skin gives way, or into the tissues and under the fascia?. Suppuration may also occur in these cases, the skin be- coming red and inflamed, and finally external rupture may follow. In the absence of history the recognition of diffuse aneurisms is by no means simple, especially when they become inflamed, and then only the most careful attention to the facts to be made out by digital examination can determine the nature of the case. 3. Suppuration is an exceedingly serious, but by no means a usual, complication. It may arise in the following ways : (a) After ligature of the main vessel above, especially when the wound becomes septic, and there is a good deal of loose cellular tissue around the sac, as in the axilla ; (b) after diffusion, partial or complete, of an aneurism, where there is great tension upon sur- rounding parts. Auto-infection or the presence of an infective embolus may finally determine the suppurative process. The tumour shows signs of inflammation, becoming hot, red, painful, and swollen, and the skin over it may pit on pressure ; whilst fever and general constitutional disturbance are also present. Sooner or later, if left to itself, the tumour points at one spot and bursts, giving exit to a mixture of blood clot, pus, and a greater or less amount of bright red blood. The patient either dies at once from syncope, or a little later from secondary haemorrhage and septic poisoning, unless efficient treatment is adopted. Occasionally, but very rarely, the afferent trunk becomes plugged by a thrombus, and spontaneous cure may thereby be induced. Treatment of Aneurisms. I. General Treatment is employed as an accessory to surgical measures, or must be depended on entirely in cases where local means are impracticable or contra-indicated, such as in internal aneurisms ; it is then to be looked on rather as palliative in nature than curative. The general condition of the patient must be care- fully investigated, since aneurisms are associated either with plethora or with an enfeebled and cachectic state of the system. In plethoric individuals, where the disease often runs a rapid course, absolute rest, both mental and physical, must be enjoined, with the removal of all sources of irritation and worry. The bowels are freely opened by a calomel purge at the commencement of treatment, and watery stools should be subsequently induced by 20 grain doses of pulv. jalapae co. two or three times a week, so as to increase the plasticity of the blood. The heart's impulse 264 A MANUAL OF SURGERY may be diminished by the use of aconite, or even by venesection when it is very forcible. Iodide of potassium is useful both for reducing blood-pressure and in cases where a syphilitic history is present. The diet must be diminished, all stimulating articles being eliminated, and only highly nutritious material allowed, and that mainly of the nitrogenous type, with as little fluid as possible. Various special methods, £.g\,Tufnell's, Valsalva's, etc., have been recommended, but it usually suffices to limit the dietary as much as is in conformity with the patient's comfort and well- being, and not to allow more than about a pint of fluid in the day. In weakly individuals, whilst enjoining strictly a recumbent posture, the surgeon should prescribe iron and a somewhat more liberal diet, in order to improve the quality of the blood. II. Surgical Treatment. — Whichever of the plans described below is selected in any particular case, the general health must be carefully attended to, and the condition of internal organs fully investigated beforehand, as great harm may follow injudicious interference, if internal aneurisms co-exist. i. Compression may be continuous or intermittent. If inter- mittent, it is applied over the main vessel leading to the aneurism by means of fingers (digital compression), or by mechanical con- trivances, for as long a period as the patient can bear, which usually does not exceed thirty minutes, especially if there is any nerve in the immediate neighbourhood. There seems to be no necessity to completely arrest the flow of blood through the sac, so long as the blood-pressure is sufficiently diminished to permit of coagulation within it. Continuous pressure can, as a rule, only be maintained under an anaesthetic, and in such cases the circula- tion through the sac is entirely stopped, so as to allow not only of its contraction, but also in some instances of the rapid coagulation of its contents. Such pressure may be effected by the fingers of relays of dressers, taking shifts of ten to fifteen minutes at a time ; but inasmuch as this is excessively tiring and difficult to maintain efficiently, arrangements should be made whereby some weight, such as a conical shot-bag, rests upon the thumb or finger em- ployed, thereby relieving muscular strain. Tourniquets may be similarly utilized, but are less satisfactory, since they require more skilful and accurate adaptation, and are liable not only to slip out of place, but also to bruise the coats of the vessels. The best appliance of this nature is probably Petit's tourniquet. Esmarch's elastic bandage has been used with success, principally for aneurisms of the lower extremities, notably the popliteal. The limb is first elevated for some moments, and then the elastic bandage applied from the toes to the upper part of the limb, passing loosely over the aneurism. An indiarubber tourniquet is then placed round the thigh, so as to arrest the circulation completely (Reid's method). The limb has in this way been left ANEURISM 265 bloodless for an hour and a half, but we cannot recommend the proceeding. Although in suitable cases compression certainly has been successful, especially in the hands of the Dublin surgeons, and may be given a trial before ligature, yet it is unwise to per- severe with it for too long if signs of improvement are not quickly observed, lest the collateral circulation be increased to an unde- sirable extent, and the success of the subsequent operation jeopardized. Especially is this the case in plethoric individuals with high arterial tension. On the other hand, in feeble, weakly patients, where gangrene of the limb might be anticipated, the opening up of the collateral circulation by compression, even if the aneurism is not thereby cured, is by no means a disadvantage. Necessarily the part of the skin to which pressure is applied must be carefully protected from local irritation by shaving and removal of hairs, by the use of dry aseptic dusting-powders, and by the surface of any pad employed being perfectly smooth, and the skin not wrinkled beneath it. 2. Ligature of the main vessels leading to or coming from the aneurismal sac must next be considered. The oldest procedure, the Operation of Antyllus, consisted in laying open the sac, turning out the clots, securing the vessel above -and below, and allowing the wound to heal by granulation (Fig. 69, A). Per- formed, as it was originally, without anaesthetics or antiseptics, it was naturally attended with great mortality, since, even if secondary haemorrhage did not occur from the main trunk, it was liable to follow from any of the branches which arose from the dilated portion of the vessel. In Anel's Method (Fig. 69, B) the artery was tied just above the sac on the cardiac side, with no branch intervening ; this also proved dangerous, since secondary haemorrhage frequently re- sulted, either from suppuration within the sac, or from injury to the sac during the operation, or from yielding of the arterial wall at the site of ligature from septic periarteritis. Hunter's Operation (Fig. 69, C), which consists of ligature of the main vessel on the cardiac side at some distance from the aneurism, was first performed by him in 1785. The object to be attained is not to absolutely cut off the blood-supply to the sac, but to allow the blood to enter it with a greatly diminished impulse, and in small amount at first, thus permitting of the contraction of the sac wall and of the gradual deposit of fibrinous clot within it. The sac thus becomes consolidated, and finally transformed into a mass of firm fibroid tissue. The operation is most likely to succeed in cases where the aneurism is well defined and not large enough to exercise injurious pressure on surround- ing parts, whilst it is desirable, though not essential, that no branch of large size should intervene between the point of ligature and the sac. The operation is contra-indicated (1) in cases where 266 A MANUAL OF SURGERY serious cardiac disease co-exists, or when an internal aneurism is also present, rendering undesirable any sudden increase of the blood-pressure, as by occlusion of a main vessel ; (2) where pressure over the vessel does not control the circulation through the sac ; (3) where the peripheral vessels are extensively calcified ; (4) where gangrene of the limb is threatening or present ; or (5) where bones or joints have been seriously involved. Distal Ligature is only practised for aneurisms situated in positions where it is impractible to deal with the artery on the cardiac side of the sac, such as the innominate, lower part of the carotid, or first part of the subclavian. Brasdor's Operation consists in tying the main trunk beyond the sac, so as to totally cut off the circulation through it (Fig. 69, D). In Wardrop's Fig. 69. — Methods of applying Ligatures for Aneurisms. A, Method of Antyllus ; B, Anel's operation ; C, the Hunterian operation ; D, Brasdor's operation ; E, Wardrop's method. Operation a ligature is placed on one or more of the distal branches (Fig. 69, E). In the former the sac gradually contracts, and thus allows of the deposit of fibrin ; in the latter proceeding, where the circulation is only partially controlled, the diminution of the size of the aneurism goes on much more slowly, and the chances of the deposition of clot in the sac are correspondingly lessened. It is not unusual, after the application of a ligature to a main artery for aneurism, to observe a return of pulsation in the sac after a few days. In the majority of cases this only continues for a short time, and is by no means an unfavourable sign, indicating the re-establishment of the collateral circulation ; but if it com- mences a week or ten days after the operation, it is more likely to persist. It is most frequently seen in cases where the main vessel has been tied at some distance from the sac, as in the ANEURISM 267 superficial femoral for popliteal aneurism, and where one or more large and important collateral branches carry blood into the artery below the ligature or directly into the sac. The early recurrence of pulsation needs no treatment in most instances, since it disappears spontaneously ; but when it comes on at a later stage, it demands serious attention. Rest, elevation of the limb and judicious pressure over the trunk above the site of ligature, should first be tried. These failing, the following courses are open : (a) The artery may be again tied, either nearer the sac when feasible, or further away from it ; (b) where the aneurism can be reached, it may be cut down on and dissected out, the best course to adopt if it be practicable ; or (c) amputation just above the aneurism may be called for as a last resource, when the tumour is rapidly increasing or threatening to become diffuse, or if gan- grene is impending. 3. Complete Extirpation of the aneurismal sac may be looked on as the best and most satisfactory method of treatment. The sac is thus dealt with as if it were a tumour, although, owing to the adhesions always present, complete separation of the wall from surrounding parts is often difficult. The limb is exsan- guinated by elevation, and in suitable cases the aneurism is removed without opening it, and the vessel secured by ligature above and below, as also any branches which may arise from it. When, however, a large saccule obscures the main trunk, it may be necessary to open it and turn out its contents before attempting its extirpation. Not unfrequently the vein will be encroached on in this dissection, and it may have to be removed ; bad results are not likely to follow, since probably its lumen has been already diminished by the pressure of the sac, and an efficient collateral venous circulation established. This method has hitherto been chiefly applied to small aneurisms of the peripheral vessels, and, indeed, in the majority of such cases no other plan need be con- sidered ; surgeons are now, however, extending its scope to the larger trunks, such as the popliteal, carotid, external iliac and subclavian, from each of which aneurisms have been successfully extirpated, whilst as far back as 1883 one of us removed in this way a recurrent femoral aneurism, involving the vein, with a good result.' 1 It is also attempted as an alternative to amputation for recurrent, diffused, and suppurating aneurisms. The results of this operation which have been recently recorded are most encouraging : primary union of the wound is often obtained, and hence the length of treatment is curtailed, whilst all chances of recurrence are removed. Statistics also show that there is less danger of gangrene, and this depends, as Pearce Gould has pointed out, on the fact that only one set of collateral circulation is called upon, viz., that required to bridge the gap made by removing the aneurism, whereas in the Hunterian operation a * Lancet, 1883, ii., p. 1082. 268 A MANUAL OF SURGERY double set is needed, viz., at the site of the ligature, and round the consolidated aneurism. It is obvious that the nutrition of the limb is best secured when what Gould calls the ' irreducible minimum ' of operative treatment, viz., the occlusion of the vessel only at the site of the aneurism, is undertaken. Secondary haemorrhage is also less likely to occur. 4. Electrolysis has been occasionally employed in dealing with thoracic aneurisms when a saccule has developed in an accessible position. The clot thus formed is soft and liable to break up, and the results have not been very satisfactory. For details of the methods of employing electrolysis, see p. 309. 5. The Introduction of Foreign Bodies into the Sac (Moore's Method) has not been followed by much success, although a few cases of abdominal aneurism seem to have derived temporary benefit from it. Steel wire has been usually employed ; it is firmly wound round a cotton reel to give it a spiral coil, and inserted into the sac through a very fine cannula. Varying lengths from 10 feet to 26 yards have been introduced. 6. The combination of the last two methods (as originally suggested and practised by an Italian, Corradi, in 1879) has been attended by some very happy results, especially in the hands of Stewart of Philadelphia." He introduces a variable length of gold or silver wire (No. 30 gauge), preferably the former, through a small cannula, and then electrolyses through the wire which is attached to the positive electrode, whilst the negative electrode is placed on the back. The current is gradually increased up to 60 or 80 milliamperes, and the whole proceeding lasts about thirty minutes. Finally, the wire is cut short and pushed into the sac. Several most brilliant results have followed this plan of treatment, including the cure of an innominate aneurism, the patient living for three and a half years, and of an aneurism of the abdominal aorta, dealt with by transperitoneal operation. We ourselves have treated a subclavian aneurism in this way with considerable temporary benefit. 7. Acupuncture has been occasionally tried for many years, but without much advantage. Macewen, however, has again drawn attention to the method, and suggested some modifications in the technique. He passes fine needles into the interior of the sac, and leaves them for a time to be played upon by the blood- stream, so as to scratch and irritate the posterior wall, and thus cause inflammatory thickening. The principle involved is entirely at variance with all the other methods of cure ; in these an attempt is made to fill the sac with blood clot, which is subse- quently organized ; Macewen looks on blood clot as undesirable material to work with, and directs his attention to thickening the walls to such an extent as to occlude the sac or to prevent subse- * British Medical journal, August 14, 1897 '• Philadelphia Medical Journal, June 25, 1898. ANEURISM 269 quent dilatation. In his own hands excellent results have been obtained ; but whilst admitting its value for internal aneurisms, we cannot but think that for those involving peripheral vessels other methods would be more rapid and equally effective. 8. Amputation may be required in the treatment of aneurisms under a variety of circumstances : (a) When gangrene of the limb has occurred or is imminent ; (b) for diffusion or suppuration of an aneurism when everything else has failed ; (c) for secondary haemorrhage as a last resource ; (d) in some cases of recurrent aneurism ; (e) when joints have been opened or bones eroded to such an extent as to impair the utility of the limb ; and, finally, (/) in a few cases of subclavian aneurism amputation at the shoulder-joint has been practised in order to diminish the amount of blood flowing through the sac. The Treatment of a Diffuse Aneurism varies somewhat according to whether the diffusion is slow or rapid. In the leaking aneurism, which increases in size somewhat slowly, the main vessel leading to the swelling may be tied, if this has not already been under- taken, and the influence of this measure, combined with rest, elevation, and careful general treatment, observed. Should the process not be stayed, the case is treated as a diffuse or ruptured aneurism by laying open the sac, after exsanguinating the limb by elevation and the use of an elastic band, and securing, if possible, the main vessel above and below, as also any branches which may open into the sac, if they can be found. If there is any evidence of incipient gangrene, or if secondary haemorrhage supervenes, amputation must be undertaken. In such cases everything will depend on the efficient maintenance of asepsis. The Treatment of an Inflamed Aneurism is always a matter of anxiety from the risk of recurrent and fatal haemorrhage. If the artery above the aneurism has not been previously ligatured, it would certainly be correct practice to tie it, and watch the effect produced by that measure, together with rest, elevation, and the local application of an icebag. If the inflammatory symptoms still continue, the aneurism should be laid freely open after applying an elastic tourniquet, the coagula turned out, and the main trunk secured above and below. If bleeding still continues from smaller branches opening into the sac, the cavity is carefully plugged with strips of aseptic gauze, but a strict watch must be kept over the case, for fear of a return of the bleeding. Should this happen, or should gangrene threaten, amputation alone remains. // the main vessel of supply has been previously tied, the sac should still be laid open and cleared of coagula, all bleeding points secured if possible, and the cavity stuffed ; amputation is, however, likely to be required. 270 A MANUAL OF SURGERY Special Aneurisms. Aneurism of the Thoracic Aorta is dealt with rather in medical than in surgical text-books ; it is, however, of such importance as to demand a short notice here. Any part of the thoracic aorta may be affected, and the symptoms arising therefrom are very variable. The fusiform type is most commonly met with in the early stages, a limited sacculation often supervening as the disease advances. In the ascending part of the arch the swelling rarely reaches a great size, especially if it is intra-pericardial, the sac usually rupturing before marked pressure signs are evident. When arising from the transverse part of the arch, the symptoms vary with the direction taken by the enlargement. If it projects upwards, a pulsating tumour may appear at the episternal notch, and cerebral effects may then ensue from interference with the circulation through the carotids, or from pressure on the venous trunks. If it extends anteriorly, it may form a large tumour with comparatively slight pressure effects, except the pain arising from its erosion of the thoracic wall ; it then appears as a pulsating swelling to the right of the sternum. If the enlargement takes place either posteriorly or downwards within the concavity of the arch, symptoms in the shape of dyspnoea and dysphagia are early produced from the close contiguity of the trachea, oesophagus, and pulmonary vessels. Dyspnoea may also be due to pressure upon the left recurrent laryngeal nerve, causing paresis of the crico-arytenoideus posticus muscle and difficulty in opening the glottis ; the voice, moreover, becomes harsh and the cough hard, with what has been described as a ' metallic ring ' about it, which is extremely characteristic. Laryngeal or tracheal stridor may be noticed in these cases, and a dragging of the trachea synchronous with the heart's action (the so-called 'tracheal tug'). Aneurisms of the descending arch and thoracic aorta often attain considerable dimensions, and may project posteriorly to the left of the vertebral column, causing a pulsating swelling. The only prominent symptoms are pain due to erosion of ribs or vertebrae and interference with deglutition, which may be so great as to suggest the presence of an oesophageal constriction ; in fact, before a bougie is passed in any case of dysphagia, it is always advisable to make certain, if possible, that an aneurism is not present. Auscultation in the left vertebral groove may reveal the existence of a systolic bruit where such a condition exists. Treatment. — Little can be done beyond ordinary medical measures, such as rest, diet, and the administration of iodide of potassium. Where the tumour could be felt in front, the intro- duction of coils of iron wire or horsehair has been attempted, and in one or two cases with partial or temporary success ; whilst Stewart's method of electrolysis and Macewen's plan of acupunc- ture have been used with some benefit for supposed cases of ANEURISM 271 sacculated aneurism. Dyspnoea may be at times severe, but tracheotomy should never be undertaken, death seldom resulting from this cause. Surgical treatment, such as ligature of the right carotid and right subclavian, or of the left carotid alone, has been adopted in cases of aneurism of the ascending aorta or of the arch. A certain amount of improvement has followed some of the operations, but of eleven cases reported by Kiister five died within the first ten days. The principles underlying such proceedings are certainly at variance with those guiding our usual treatment of an aneurism, and it is quite possible that the improvement was as much due to the enforced rest in bed as to the operation. Of course, if the lower end of the carotid is involved in the aneuiismal swelling, distal ligature may do some good, as in a case of our own," where the left carotid and subclavian were tied, with a short interval between the operations. The patient's condition improved greatly for a time, and she was able to return to work, but the aneurism finally burst into the left pleura about three years after the first operation. Innominate Aneurism is usually of the tubular variety, and frequently associated with a similar enlargement of the aorta. It presents a pulsating tumour behind the right sterno-clavicular articulation — i.e., between the heads of origin of the sterno-mastoid — projecting either into the episternal notch or outwards into the subclavian triangle, and perhaps pushing the clavicle forwards. The effects produced by its pressure are very variable. The pulse in both the right temporal and radial arteries is diminished ; oedema of a brawny character of the right side of the head and neck, and of the right arm, is caused by pressure on the right innominate vein, whilst less commonly similar changes on the left side may follow compression of the left vein or of the superior vena cava ; pain shooting into the neck and arm is often a marked symptom, arising from implication of the cervical and brachial nerves, whilst hyperemia of the right side of the face and dilata- tion of the right pupil may result from irritation of the sympathetic trunk. Dyspnoea is induced by direct pressure on the trachea, which may be displaced or flattened, or by irritation of the right recurrent laryngeal nerve, causing partial or complete paralysis of the right vocal cord. Dysphagia occurs from pressure on the oesophagus. The course of the case is slowly progressive, and death most commonly results from asphyxia or from rupture of the sac. Treatment. — Rest and the administration of large doses of iodide of potassium may cause improvement, but distal ligature is the most hopeful proceeding. It is obviously impossible to cut off all the blood passing through the sac to the three main divisions — viz., the carotid, subclavian, and vertebral — with safety to the * British Medical Journal, December 3, 1898. 272 A MANUAL OF SURGERY patient (Fig. 70). Ligature of any one of these alone offers but little prospect of improvement ; thus, the only case benefited by ligature of the subclavian was one treated by Wardrop, in which the carotid also had been independently and by accident blocked ; whilst the only cure recorded after tying the carotid was probably due to subse- quent suppuration within the sac (Evans). Ligature of both carotid and subclavian, with an interval of more than a week between the two operations, has practically the same effect as a single ligature, for by that time the collateral circulation Fig. 7 o-Application of Ligatures ™ U have , be f„ established. for Innominate Aneurism. (After 1 he _ results following such Erichsen.) practice are better than those IA, innominate aneurism; S, sub- gained by ligating a single clavian artery ; C, carotid ; V, vertebral vessel, but not SO good as those artei 7- from tying both vessels at the same time. Simultaneous liga- ture is doubtless the best plan of treatment to adopt ; it places the sac in the best possible condition for the deposit of fibrin, whilst the additional step of tying the third part of the subclavian does not materially add to the risk of the operation, which is mainly due to the effect on the cerebral circulation. Should operative measures seem undesirable, recourse must be had to Stewart's or Macewen's methods. Aneurism of the Common Carotid is usually situated at the upper part of the trunk near the bifurcation, and more often on the right than on the left side. The root of the right carotid as it springs from the innominate is also not unfrequently dilated, but the intra-thoracic portion of the left carotid is rarely affected, except in conjunction with aneurism of the aorta. No other external vessel is so frequently the seat of aneurism in women. The ordinary intrinsic signs of an aneurism are present, and the pressure symptoms are mainly referable to interference with the cerebral circulation, to irritation of the cervical sympathetic trunk, or to pressure upon the larynx, pharynx, or trachea. The progress of these cases is usually slow. Diagnosis. — (1) From similar disease at the root of the neck the dis- tinction is often made with difficulty, since either an aortic, innominate, or subclavian aneurism may push upwards so as to simulate it somewhat closely. Percussion and auscultation of the upper part of the chest, together with a careful investigation ANEURISM 273 into the history of the case, and a digital examination of the limits of the pulsating mass, may suffice to determine the point. Holmes suggests trying the effect of carefully applied distal pressure for a few hours ; in a carotid aneurism the tension becomes distinctly less as the collateral circulation commences to enlarge, whilst in an aortic aneurism no difference is observed. The pressure effects must also be carefully considered. ' Pressure on the left recurrent laryngeal nerve would distinguish an aortic aneurism from one on the right vessels ; pressure on the right nerve in like manner excludes an aortic aneurism. Pressure on the left innom- inate vein indicates aortic aneurism rather than innominate ; com- pression of the internal jugular or subclavian vein only points to carotid or subclavian aneurism. A " tracheal tug " indicates an aneurism of the aorta' (P. Gould). The differences in the peri- pheral pulses may also give useful information. The two radial pulses should be first examined ; if they are equally affected, an aneurism of the aorta on the cardiac side of the innominate is indicated ; if they are equal and normal, an aneurism on the distal side of the origin of the left subclavian. If the left radial pulse is alone aneurismal, the root of the left subclavian is diseased, whilst if the left temporal is also affected, it suggests an aneurism of the transverse part of the arch beyond the innominate. When both radial and temporal vessels on the right side show signs of inter- ference with the pulse, innominate aneurism is probably present, whilst an affection of only one of these branches indicates that the corresponding carotid or subclavian is dilated. One source of fallacy must not be forgotten, viz., that any one of these trunks may be occluded or compressed by a neighbouring aneurism with- out being dilated, and hence the quality of the pulse must be taken into consideration rather than its actual volume, and to this end the sphygmograph is a useful adjunct in diagnosis. (2) From abscess, tumours, or enlarged glands with a transmitted impulse, a carotid aneurism is recognised by an application of the general principles detailed above (p. 261). (3) Pulsating or cystic goitre may be distinguished from a carotid aneurism by noting that the goitre is not, as a rule, limited to one side of the neck, the isthmus being also involved ; that the most fixed part of the tumour is in the median line, and not under the sterno-mastoid muscle, and that the swelling moves up and down during deglutition, an aneurism remaining fixed. (4) An aneurism close to the bifurca- tion may be simulated by an abnormal arrangement of the terminal branches, the external carotid crossing the internal from behind forwards, and being pushed outwards sufficiently to cause a pulsating swelling beneath the skin. This condition is usually symmetrica], and can be recognised by careful palpation. Treatment. — Ligature of the carotid above or below the omo- hyoid is the treatment usually adopted, and generally with great success. If the aneurism is near the root of the neck, proximal 18 274 A MANUAL OF SURGERY ligature becomes impracticable, and the distal operation (Brasdor's) must be undertaken. Aneurism of the External Carotid is seldom met with, except as an extension of one involving the bifurcation. The usual pheno- mena are presented near the angle of the jaw, and well above the thyroid cartilage. Pressure results are early experienced, e.g., paralysis of one side of the tongue through implication of the hypoglossal nerve, aphonia, or dysphagia. In suitable cases, the sac may be dissected out after securing the branches arising from it, as recently recommended by Walsham.* Failing this, the common trunk must be tied. Aneurism of the Internal Carotid (extracranial portion). — There is but little difference between the symptoms arising from this condition and those caused by an aneurism of the bifurcation or of the external carotid, except that the swelling projects more into the pharynx, from which it is separated merely by the pharyngeal wall. It appears as a tense pulsating tumour, placed immediately under the mucous membrane, and looking danger- ously like an abscess of the tonsil. The Treatment consists in tying the common carotid. Intracranial Aneurism. — Any of the arteries within the skull may become the site of an aneurism, but this condition occurs more commonly upon the internal carotid and its branches than upon those arising from the vertebrals, although the basilar artery is more often affected than any other single vessel. The aneurisms are generally fusiform in character, and their origin is often extremely obscure, a blow or fall being sometimes adduced to explain them ; in children they are stated to result from the lodgment of septic emboli. They sometimes grow to a con- siderable size before causing obvious symptoms ; the patient may, in fact, have continued without any manifestation of the disease, until suddenly seized with a rapidly fatal apoplexy from rupture of the sac. If there are any symptoms, they are due rather to compression of the brain than to erosion of the more resistant bony structures. Pain which is more or less fixed and continuous may be complained of, or there may be a feeling of pulsation, or of opening and shutting the top of the skull. Sight, hearing, and other functions of the brain, may also be interfered with, but physical changes in the eyes, such as optic neuritis or atrophy, are not induced, unless there is direct pressure on some part of the optic tract. Occasionally a loud whizzing bruit may be heard on auscultating the skull. The only Treatment possible, if a diagnosis can be established, is ligature of the common carotid artery, and even this will be of little use if the basilar is affected. * Trans. Med Chiv. Soc, February 28, 1899. ANEURISM 275 An Intra-orbital Aneurism is recognised by the existence of a pulsating swelling of the orbit, causing protrusion of the eyeball (exophthalmos) and congestion of the conjunctival and deeper vessels. A feeling of pain or tension in the orbit may exist, and gradually vision is impaired, whilst the cornea may become opaque from exposure, due to the inability of the lids to cover it ; finally, the whole globe may be disorganized. The symptoms sometimes commence with a definite snap or crack, as though something had given way in the orbit ; or they may follow a penetrating injury or a blow. Occasionally the condition is con- genital, or arises soon after birth. Several pathological lesions are included under the title ' intra- orbital aneurism': (a) If congenital, it is probably a case of aneurism by anastomosis ; this, however, is not common, being present only in two out of seventy-three cases collected by Rivington ; (b) if traumatic in origin, whether due to a pene- trating injury or not, the case is probably an aneurismal varix between the internal carotid and cavernous sinus, or a genuine traumatic aneurism of the ophthalmic artery ; (c) if idiopathic, it is possibly due to thrombosis of the cavernous sinus, or to spon- taneous aneurism of the internal carotid or ophthalmic arteries. Diagnosis. — To determine the precise cause of a pulsating tumour of the orbit is by no means an easy matter, inasmuch as sarcomata are occasionally met with exhibiting many of the characters of intra-orbital aneurism. Careful palpation will, how- ever, generally demonstrate the existence of a more definite tumour, and a less-marked expansile pulsation in the sarcoma, whilst the bruit is less distinct. The distortion of the eyeball and ocular axis is often considerable in malignant tumours, but vision is not so early aftected. Treatment. — Electrolysis and ligature of the common carotid are the only means which hold out any prospect of success, and of these the former should always be first tried. In the congenital cases its application has been very successful, but in those due to trauma it is very likely to fail. Subclavian Aneurism is most frequently seen in men, and particularly those who use their arms much in lifting, such as soldiers and sailors ; the right vessel is more often affected than the left. Any part of the artery may be involved, but the greatest dilatation naturally occurs in the third portion. A pulsating tumour develops in the subclavian triangle, which may reach above the clavicle, but chiefly extends backwards, outwards, and downwards, causing pressure effects upon the veins and nerves of the arm, and also hiccough by irritation of the phrenic. Occasionally it encroaches on the dome of the pleura and apex of the lung, and has been known to burst into the pleural cavity. It does not increase in size very rapidly, being surrounded by 18—2 276 A MANUAL OF SURGERY dense unyielding structures, and never compresses the trachea or oesophagus. No difficulty presents itself in Diagnosis as a rule, although in the early stages it may be somewhat simulated by a normal artery pushed forwards by an exostosis of the first rib, or by a supernumerary cervical rib. A pulsating sarcoma growing from any of the neighbouring structures may also resemble it some- what closely, but the pulsation is then rarely so limited in extent as in an aneurism, and a definite tumour can usually be felt. The Treatment of subclavian aneurism is surrounded with difficulties, and the results hitherto obtained have been most unsatisfactory. Extirpation has been undertaken in one case" with success after turning up the middle third of the clavicle, but the aneurism is seldom sufficiently limited to allow of the applica- tion of this ideal proceeding. Should any undilated portion of the artery be available outside the thorax, digital compression on the cardiac side may be attempted. Direct pressure, manipulation, galvano-puncture and needling the sac according to Macewen's method, have been adopted with occasional success, but cannot be relied on. Stewart's method proved of benefit in a case we recently had under treatment, the aneurism becoming much firmer, and the patient being freed from pain and able to return home. Unfortunately he died three months later from haemorrhage, but no post-mortem examination was obtainable. About 10 feet of gold wire were introduced. Ligature of the innominate trunk suggests itself as the operation to be adopted for cure by the Hunterian method, and recent records would certainly encourage one to repeat it in any suitable case, since most of the fatal results occurred prior to the introduction of antiseptic surgery, death resulting from sepsis or secondary haemorrhage. It would appear that the simultaneous ligature of the carotid or vertebral trunks with the innominate is essential to success, in order to prevent the rapid backflow on the distal side of the ligature which otherwise occurs ; in addition, the coats of the vessel must be approximated by a broad animal ligature, e.g., of gold-beater's skin, and not divided. Ligature of the first part of the subclavian has also been attempted for the cure of aneurisms involving the lower part of the vessel, but until recently it was so uniformly fatal that it was con- sidered quite an unjustifiable proceeding, the first nineteen cases all dying. Clutton,t however, has reported a successful case, the ligature being applied (without dividing the coats) on the proximal side of the thyroid axis and internal mammary vessels, which were also secured. The first part of the axillary and the superior intercostal had also to be tied before pulsation in the aneurism ceased. Halsted| has since reported a second successful case of this operation. Ligature of the second part of the subclavian * Moynihan, Annals of Surgery , July, 1898. t Trans. Med. Chir. Soc, vol. lxxx., p. 391. J Annals of Surgery, May, 1900. ANEURISM 277 has been advantageously employed in suitable cases where the aneurism was situated below it. Distal ligature of the third part has also been attempted, but without much success. As a last resource, where the above measures are impracticable or have failed, the plan suggested by the late Sir William Fer- gusson may be followed, viz., amputation at the shoulder-joint and distal ligature as near the sac as possible. Distal ligature alone is usually unsuccessful, owing to the fact that the great bulk of the blood needed for the nutrition of the arm still passes through the sac, and there is no means of checking this except by the removal of the limb. A few successful results of such heroic treatment have been reported. Axillary Aneurisms is usually the result of falls on the out- stretched arm. or injuries to the shoulder, such as fractures or dislocations, or of attempts to reduce them. The Symptoms are merely those due to the presence of a pulsating tumour and its pressure, which may cause pain, local and neuralgic, or oedema of the arm. When the upper part of the vessel is affected, a pulsating swelling is felt immediately below the clavicle, whilst if placed lower down it projects more into the axilla, and may totally fill up the hollow. Occasionally the clavicle is displaced upwards, or the aneurism may extend beneath it into the neck, conditions of serious import as regards treatment. Treatment. — Compression (digital) or ligature of the third part of the subclavian artery is required, but if the aneurismal sac extends under the clavicle, it may be necessary to secure the second part of the artery, due care being taken of the phrenic nerve. Aneurisms of the brachial artery, or of any of the vessels of the forearm, require no special notice. They are almost invariably traumatic in origin, and should be treated by extirpation. Abdominal Aneurism. — The abdominal aorta may become the seat of aneurism, either at the upper part near the cceliac axis, or at the bifurcation ; in the former case, some of the branches arising at that spot are also usually involved, and the disease is of the sacculated type. Occasionally aneurisms form independently on the splenic or mesenteric vessels. A pulsating tumour is observed, usually near the middle line, and either close to the umbilicus or in the epigastric notch ; the pulsation is expansile in type, and remains the same in character whatever the position of the patient. Pressure signs are mainly confined to pain, localized in the back from erosion of the vertebrae, or neuralgic from pressure on the solar plexus or lumbar nerves, whilst oedema of the lower extremities may arise from compression of the vena cava. There may be some concurrent derangement of the intes- tinal functions. 278 A MANUAL OF SURGERY Diagnosis. — Many conditions give rise to epigastric pulsation, but the majority of them can be readily distinguished from abdominal aneurism by careful examination, if necessary, under an anaesthetic. Cardiac pulsations may be felt in the epigastrium when the heart is dilated, but should be easily recognised ; as also an impulse transmitted from the aorta through a collection of fasces, or a cancerous growth. The examination of such a case should be conducted not only in the dorsal decubitus, but also in the genu-pectoral position so as to remove the weight of the viscera from the aorta, when the pulsation will cease, or become much diminished. A large accumulation of abdominal fat will seriously interfere with any satisfactory investigation. Treatment. — Ligature of the aorta even on the distal side has has never yet been attempted for this condition, and hence, failing medical treatment by rest and diet, compression was formerly relied on, being applied either on the distal or proximal sides of the sac. The method is, however, clumsy and liable to cause serious mischief to the abdominal viscera. More recently treat- ment by needling the sac has been employed, and certainly in Macewen's hands at least one case has been brilliantly success- ful. There is also one instance on record where the introduction of wire into the sac, combined with electrolysis through the wire by Stewart's method, cured an aneurism as large as an orange ; the abdomen was opened, and electrolysis was maintained for thirty-seven minutes. Iliac or Inguinal Aneurism arises from either the common or external iliac, or from the common femoral, and usually tends to spread upwards towards the abdominal cavity. It is frequently sacculated in type, and is certain sooner or later to become diffuse. Its shape is determined by the unequal pressure exercised by fascial or other structures, sometimes leading to lobulation. The symptoms are very typical, and pressure effects are mainly ex- perienced in the veins and nerves of the leg. The Diagnosis cannot be well mistaken in the early stages, but later on, and specially when situated high in the iliac fossa, it may be difficult to distinguish from a pulsating sarcoma. Treatment. — Medical treatment alone is of little avail in curing inguinal aneurisms; but proximal compression of the aorta or common iliac, where the situation of the swelling and the thickness of the abdominal parietes permitted it, has had a certain amount of success. It is carried out by means of a tourniquet, shot-bag, or the fingers, and may be advantageously combined with distal pressure. Ligature of the external iliac has been frequently per- formed for inguinal aneurism, and with such success as to warrant its being employed in all suitable cases. Ligature of the common iliac is sometimes needed for aneurisms in the iliac fossa. The results of the retro-peritoneal operation were by no means satisfac- ANEURISM 279 tory, but the introduction of the trans-peritoneal method of ligature and the recognition of the importance of not dividing the inner and middle coats in such a large vessel, combined with the use of aseptic animal ligatures, are certain to lead to better results. In ten instances ligature of the abdominal aorta has been undertaken for iliac or inguinal aneurism, and in all a fatal issue followed, seven of the patients dying within forty-eight hours ; one survived as long as the tenth day, and two lived for forty-eight and thirty-nine days respectively. Of course, wherever practicable, extirpation should be resorted to, and at least one most successful case has been published. Aneurisms of the Gluteal and Sciatic Arteries are usually traumatic in origin, and present as pulsating swellings of variable size in the buttock, the gluteal situated at the upper part of the sciatic notch, whilst the sciatic lies more deeply, and may be partly intrapelvic. Pulsation is well marked, and murmurs are heard on auscultation. Pain in the limb from pressure on the sciatic nerve is a prominent sympton, especially in the sciatic variety. The Diagnosis is by no means simple, especially from a pulsating sarcoma, and many instances of mistakes have occurred even in the practice of eminent surgeons. Treatment. — The best results hitherto obtained have followed the laying open of the sac, turning out the clot, and tying the affected trunk — a proceeding requiring operative dexterity and skill of the highest order. Ligature of the internal iliac has also been performed, and with a creditable degree of success, even where the old extra-peritoneal method was employed. The use of the trans-peritoneal route greatly simplifies the operation, and the more recent records of this proceeding are most satisfactory. At the present time it should certainly be undertaken in preference to the plan of laying open the sac. Femoral Aneurism is the title given to one forming in the course of the superficial femoral artery. It is not uncommonly tubular, and occurs almost invariably in males, and as often on one side of the body as the other. The Diagnosis needs no discussion, as the disease runs a typical course, and the Treatment consists either in extirpation, compression at the groin, or ligature of the common or superficial femoral trunk. Aneurism of the Profunda Femoris Artery is a very rare con- dition, presenting the ordinary features of a pulsating tumour situated amongst the muscles on the inner side of the thigh, but causing no diminution of the pulse in the popliteal or tibial vessels. The superficial femoral may be felt coursing over it, but quite distinct. Compression by a shot bag in the groin, or by a tourniquet, may be sufficient to effect a cure, whilst 2SO A MANUAL OF SURGERY ligature of the common femoral or external iliac may be resorted to, if neceessary. Popliteal Aneurism (Fig. 71) occurs almost invariably in men, constituting a pulsating tumour in the ham, rendering the knee painful and stiff, and so much do the symp- toms resemble those of chronic rheumatism that in every such case the popliteal space should be examined. The limb is usually semiflexed, and the aneurism, which is of a sacculated type, often increases rapidly in size. If the main swelling is situated to the front of the vessel, there is some likelihood of the knee-joint becoming implicated, and neighbouring bones carious ; when it extends posteriorly, diffusion is not uncommonly followed by gangrene, on account of the pressure exercised not only upon the vein, but also upon the articular branches of the popliteal artery, which are most important factors in maintaining the collateral circula- tion. The diagnosis has to be made from chronic enlargement and abscess of the glands in the ham, but in these there is less disturbance of the circulation in the foot ; from bursal tumours, by their want of mobility and pulsation ; or from solid tumours, e.g., pulsating sarcoma of the femur or tibia, from which it can be recognised by attention to the general principles already enunciated. In a few instances spontaneous cure has resulted from the pressure of the sac upon the artery above. Treatment. — Compression is eminently successful in many of these cases, whether applied in the groin or by Reid's method. Ligature of the femoral artery at the apex of Scarpa's triangle is, however, the plan most commonly adopted, and with the greatest success. In cases where either of these methods has failed, or where the aneurism has become diffuse or recurred, extirpation of the sac is the best course to adopt. Fig. 71. — Popliteal Aneurism. Ligature of Vessels. Ligation in continuity is an operation performed to arrest the flow of blood to the periphery, in order either to check haemor- rhage, or to promote the cure of an aneurism, or to diminish the rate of growth of some tumour, or to beneficially influence some peripheral organ by reducing its blood-supply (as in tying the internal iliac for enlarged prostate), or as a preliminary to remov- ing some vascular structure, such as the tongue. LIGATURE OF VESSELS 281 The Instruments needed are as follows : scalpels, dissecting forceps, director or blunt dissector, forcipressure or artery forceps, blunt hooks, retractors for deep wounds, aneurism needle, ligature, needles, and sutures. The Material to be employed for the ligature has been discussed elsewhere (p. 18). Sulphuro-chromicised catgut is that most commonly employed for all but the largest trunks, and for its application to an artery in its continuity the following plan may be adopted : A fine loop of catgut having been passed under the vessel by means of an aneurism needle, a prepared ligature, con- sisting of three strands of catgut about 10 inches long, knotted together at each end, is threaded through the loop, which is then withdrawn, carrying the ligature under the vessel. The advan- tages of this method are, that the aneurism needle, being threaded with such fine gut, passes easily and without friction, whilst the use of the loop to draw the ligature back obviates the difficulty, where the artery is deeply placed, of threading the needle if passed unarmed, as is sometimes advised. The substitution of three strands for a single ligature distributes the pressure over a larger area, and is considered more certainly to effect occlusion. As to the Operation itself, the strictest asepsis must be main- tained, the skin and instruments being thoroughly purified pre- viously. The artery is examined, as far as is possible, so that a healthy portion may be selected for applying the ligature. The various structures met with on the way to the artery are recog- nised, and drawn, if need be, to one or the other side, so as to lay bare the sheath of the vessel. It is most important that these anatomical landmarks or rallying points should each be seen or felt in order, so that the operator may not be led astray or miss the vessel. Naturally it is easier to find the artery in the living subject than in the dead, the pulsation being of the greatest assistance. The sheath, having been exposed, must now be opened over the situation of the artery by a few delicate strokes of the knife ; a portion of the sheath should be picked up between the blades of the forceps, incised along the longitudinal axis, and stripped off the artery, taking care to keep the back of the knife towards the vessel. This incision should be about f inch in length, and should open not only the general, but also the special, sheath of the artery, if such exist. The sheath is then steadied with forceps, whilst the aneurism needle is inserted unarmed, and gently manipulated up and down, so as to free the vessel all round, a matter of no great difficulty, if the sheath has been sufficiently opened, and the actual arterial wall fairly exposed. The ligature may then be passed through the eye of the needle, and carried round the vessel. It is tied in a direction exactly at right angles to the longitudinal axis, and in doing so the artery must not be dragged out of its sheath, but the ligature should be tightened by the tips of the forefingers meeting upon it. A reef-knot is all that 282 A MANUAL OF SURGERY is necessary for security in the smaller vessels, but in the largest trunks it may be advisable to employ what has been termed the stay-knot. Two strands of ligature material are passed round the vessel side and half knotted ; the two ends on each side are then taken up together and tied across in one knot. The rule usually followed is to pass the needle from important struc- tures, such as the vein, but really this is a matter of little importance when the above directions have been carefully carried out, and especially in superficial vessels. Should the vein be accidentally punctured, the needle must be at once withdrawn, and the punc- ture in the vein secured by ligature, whilst the artery is tied a little higher or lower. In dealing, however, with the smaller vessels, where the venae comites are in close contact with the artery, no harm will attend their inclusion in the ligature. After - Treatment. — The ordinary antiseptic precautions are taken in regard to the wound, which should be healed and all stitches removed in eight days ; but the patient must be kept at rest for some time longer to allow the tissues to consolidate, especially in dealing with the larger vessels and in elderly people. When the main artery to one of the extremities has been tied, the limb should be wrapped in cotton-wool and slightly raised. If there is any likelihood of gangrene, as in the lower limbs of elderly people, the extremity should be thoroughly purified, and wrapped in aseptic wool immediately after the operation, in order to avoid septic complications. There are two great dangers liable to follow the ligation of an artery in its continuity : i. Secondary Haemorrhage (vide p. 239). 2. Gangrene, which may arise from a variety of causes : (a) From simple loss of vitality, the maximum amount of blood transmitted by the collateral circulation being insufficient to maintain in life the whole of the part supplied by the artery ligated. This is particularly the case when the peripheral vessels are in a condition of calcareous degeneration. The tissues which receive the smallest amount of blood die first, e.g., the fingers or toes, or the subcortical white substance of the brain. Severe loss of blood after the operation, as from secondary haemorrhage, is also sufficient in some cases to determine tissue necrosis. Under such circumstances it always takes on the dry form if involving the terminal joints of a limb, but in more fleshy parts it may be moist, (b) Interference with the venous return, as by injury to the vein during operation, such as inclusion in the ligature, or thrombosis induced subsequently by septic periphlebitis, is very likely to cause gangrene, and then it is of the moist type ; the in- jurious pressure of a tight bandage, obstructing the venous circula- tion, will have a similar effect, (c) Injudicious after-treatment, such as too great elevation of the limb, the application of cold lotions, an icebag, or fomentations during the period of diminished LIGATURE OF VESSELS 283 vitality immediately following the operation, or even an attack of erysipelas, may also bring about the death of some of the tissues involved. Every precaution must be taken to prevent the occurrence of gangrene, as indicated above, and as soon as there is any sus- picion of its onset the whole limb must be thoroughly purified, and subsequently maintained aseptic. The Treatment of aseptic gangrene following ligature is expectant in character, the parts being allowed to separate naturally. But if there is much pain, or any tendency to spread, or if septic mischief is present, giving rise to fever and general disturbance, it is wiser to remove the limb well above the line of demarcation. The Innominate Artery has now been tied with success on six separate occasions out of a total of about thirty operations. An incision is made along the lower third of the anterior border of the sterno-mastoid, and is prolonged downwards to sweep over the upper edge of the episternal notch. The platysma, the superficial and deep fasciae are divided, and the anterior jugular vein secured if necessary between two ligatures ; the sterno-mastoid is drawn outwards, and its inner tendinous fibres are divided, whilst the sterno-hyoid and -thyroid muscles are severed close to the sternum and drawn inwards. The carotid sheath is now laid bare and opened at its lower part, so as to expose the carotid artery and enable it to be tied, and by following this downwards the innominate trunk is reached. In some cases it may expedite matters to remove portions of the sternum and inner end of the clavicle. The right internal jugular and innominate veins lie to the outer side of the vessel, but if much engorged may project over the artery, and must then be drawn aside by retractors, whilst the inferior thyroid plexus may course directly in front of the vessel, and even need to be ligatured. To the outer or right side are placed the vagus nerve and pleural sac, and these must be carefully separated from the artery, whilst the needle is passed from without inwards, and from below upwards. A double-curved aneurism needle will probably be required to effect this. A broad animal ligature should be used for this vessel, and the inner and middle coats must not be divided. Collateral Circulation. — Intracranial: Vertebrals and carotids in the circle of Willis. Face and Neck : Branches of the two external carotids across middle line. Trunk : First aortic intercostal with superior intercostal of subclavian ; upper aortic intercostals with thoracic branches of axillary and intercostals of internal mammary ; deep epigastric and phrenic with terminal divisions of internal mammary. The Carotid Artery may be tied at one of two places, either above or below the level at which it is crossed by the anterior belly of the omo-hyoid. The line of the vessel is indicated by that drawn from the sterno-clavicular articula- tion to a point midway between the angle of the jaw and the tip of the mastoid process, the bifurcation being situated on a level with the upper border of the thyroid cartilage. Ligature above the Omo-hyoid. — This operation is usually chosen, if practicable, since the vessel is here more superficial, the ligature being applied on a level with the cricoid cartilage. The patient lies upon the back, with the chin raised and the head turned a little towards the opposite side. A 3-inch incision is made in the line of the vessel, the centre on a level with the cricoid (Fig. 72, A). The skin, platysma, and fasciae are divided, and the anterior edge of the sterno- mastoid defined as the first rallying-point. The deep fascia is incised along its inner border, so that it may be drawn aside by a retractor ; the sterno-mastoid 284 A MANUAL OF SURGERY branch of the superior thyroid artery may be divided at this stage, and a vein passing between the facial and anterior jugular may also need to be ligatured. ( )n the inner side of the wound the omo-hyoid muscle must now be looked for, trending forwards and upwards from under cover of the sterno-mastoid. In the angle formed by these two structures the pulsation of the vessel should be felt and the sheath readily recognised, with the descendens cervicis nerve upon it. It is opened on the inner side, and the artery well cleared. The needle is passed from without inwards, and if the sheath has been efficiently opened, the vagus nerve will run no risk of being included. Ligature below the Omo-hyoid. — The incision is made in a similar direction to the above, but lower in the neck, reaching from the cricoid cartilage nearly to Fig. 72. — Incisions for Various Operations on Head and Neck. For ligature of carotid ; V, for ligature of vertebral artery ; B, for ligature of subclavian ; C, for ligature of the first part of the axillary ; M, for the internal mammary ; H, for the lingual ; E, flap incision used in trephining for meningeal haemorrhage ; F, flap incision for operations on the roots of the fifth nerve. the sterno-clavicular joint. The sterno-mastoid is drawn outwards, and per- haps the anterior fibres may need to be divided ; the sterno-hyoid and -thyroid muscles are retracted inwards or divided, and the omo-hyoid can usually be drawn upwards. The sheath is thus exposed, and opened on the inner side, the needle being passed as in the previous operation. It must be remembered that both internal jugular veins are directed towards the right side in the lower part of their course, and hence the left vein is likely to lie somewhat in front LIGATURE OF VESSELS 285 of the artery. The inferior thyroid veins may also be seen, and need to be drawn aside or ligatured. The effects of ligature of the carotid upon the brain are of great interest and importance. Statistics go to prove that in about 25 per cent, of the patients operated on cerebral symptoms manifest themselves, either immediately in the form of syncope from cerebral anaemia, or in the course of a few days from cerebral softening, causing paralysis on the opposite side of the body, and even death. A fatal issue is likely to result in about half the cases thus affected. Occasionally a somewhat acute form of congestion of the lungs follows ligature of the carotid within a few hours, possibly due to interference with the circulation in the medulla, or to irritation or injury to the vagus or sympathetics ; it may run on to subacute inflammation, and is best remedied by free stimulation, or venesection. Collateral Circulation. — Intracranial : Circle of Willis. Extracranial : Communications across the middle line of branches of the external carotids and vertebrals ; inferior thyroid with the superior thyroid ; profunda cervicis with princeps cervicis of occipital ; superficial cervical with branches of occipital and vertebral. Ligature of the Internal Carotid is rarely needed, but has been employed for haemorrhage and traumatic aneurisms. Any part of the vessel may be tied, but the ligature is usually placed just above the bifurcation. The operation is practically the same as for securing the common carotid, only at a higher level. An incision is made along the anterior border of the sterno-mastoid, its centre being opposite the great cornu of the hyoid bone ; the muscle is pulled well backwards, and the posterior belly of the digastric is now seen and drawn up. The external carotid presents itself, and is carefully displaced forwards, and then the internal carotid in its sheath appears. The latter is opened, and the aneurism needle passed from the jugular vein. The Collateral Circulation to the brain is maintained by the circle of Willis. Ligature of the External Carotid is occasionally required, the site of election for applying the ligature being between the superior thyroid and lingual branches. An incision is made along the anterior border of the sterno-mastoid, 3 inches in length, its centre corresponding to the great cornu of the hyoid bone. The edge of the muscle is defined and drawn outwards, and the posterior belly of the digastric sought for above, the hypoglossal nerve lying just below it. The sheath is now opened below the tip of the great cornu of the hyoid bone, and the needle passed from without inwards. The operation may be rendered exceedingly difficult by the presence of enlarged glands or veins, especially the lingual, facial and superior thyroid, which often lie directly in front of the vessel. The superior laryngeal nerve is placed immediately behind it, and must necessarily be avoided. Collateral Circulation. — Vide ligature of common carotid (extracranial portion). Ligature of the Lingual Artery is chiefly needed as a preliminary to removal of the organ for malignant disease ; it is also occasionally employed in traumatic cases. The vessel can be secured either close to its origin from the external carotid, or in the submaxillary triangle under cover of the hyoglossus muscle. In the Submaxillary Triangle. — The patient lies on his back, with the shoulders raised, and the head extended backwards and turned to the opposite side. A crescentic incision commencing about 1 inch below and external to the symphysis menti, and skirting the angle of the jaw, is made, the centre opposite the great cornu of the hyoid bone (Fig. 72, H). The integument and platysma are divided, the lower border of the submaxillary gland is defined, and along it the deep fascia is incised. The gland is now drawn upwards, and held over the margin of the jaw with a retractor (Fig. 73, Gs). On thoroughly opening up the wound the two bellies of the digastric muscle (.1/ biv) are seen converging to the hyoid bone (Z), the 286 A MANUAL OF SURGERY anterior belly passing superficial to the fibres of the mylohyoid muscle (M myho), which course nearly transversely to the mandible, and of which the posterior fibres may be divided with advantage. The digastric tendon is drawn down with a blunt hook, and in the space thus cleared the hyoglossus muscle (M hyogl) becomes evident, with its fibres passing vertically upwards, and resting upon it the hypoglossal nerve (5), coursing forwards to get under cover of the mylohyoid, and either above or below it the ranine vein. The fibres of the hyoglossus are now divided transversely midway between the nerve and the hyoid bone, and in the opening made by their retraction is seen the artery (3), lying on the middle constrictor. Should it not be found in this situation, the incision in the hyoglossus should be extended backwards, and the vessel will then usually come in sight. In the Neck close to its Origin. — An incision is made along the anterior border of the sterno-mastoid similar to that needed for ligature of the external carotid. Fig. 73. — Ligature of Lingual Artery. (Tillmanns.) The submaxillary gland (Gs) has been drawn over the side of the jaw with a hook ; Z , hyoid bone ; i, external carotid ; 2, internal jugular ; 3, lingual artery ; 4, ranine branch of facial ; 5, hypoglossal nerve ; M biv, digastric ; M styl, stylohyoid; M myho, mylohyoid ; M hyogl, hyoglossus. The place where the artery is tied is indicated by a window in the hyoglossus, through which it can be seen. The muscle is drawn backwards, and the great cornu of the hyoid bone defined. The small space is now cleared between that bony process and the posterior belly of the digastric, in which the artery can be felt resting upon the middle constrictor, and secured just as it rises from the external carotid. The Facial Artery may be exposed and tied through a horizontal incision, 1 inch in length, made directly over the vessel as it crosses the lower border of the jaw immediately in front of the masseter. The platysma will need division, as well as the skin and fascia. The Temporal Artery is reached in front of the auditory meatus, and as it crosses the zygoma, through a vertical incision. It is merely covered by skin and fascia, but must be carefully isolated from the auriculo-temporal nerve. The Occipital Artery is tied through an incision extending from the apex of the mastoid process backwards for about 2 inches towards the occipital pro- tuberance. The posterior fibres of the sterno-mastoid, the splenius and LIGATURE OF VESSELS 287 trachelo-mastoid are divided so as to expose the artery as it emerges from the groove on the under surface of the mastoid process, where it is easily secured. The Subclavian Artery has been tied in each part of its course, but most frequently in the third. Ligatures of the first and second parts are such unusual proceedings that we must refer students to larger text-books for descriptions. Ligature of the third part is performed for axillary aneurism, for haemorrhage, as a distal operation for aortic or innominate aneurism, and sometimes as a preliminary to amputation of the upper extremity. The patient is placed on the back, close to the edge of the table ; the arm is well depressed, and the head turned to the opposite side. The skin is now drawn down by the left hand, and an incision 3 or 4 inches long made over the clavicle (Fig. 72, B). On releasing the skin it retracts upwards, so that the wound comes to be situated about J inch above the clavicle, and thus the external jugular vein is more efficiently protected. The incision should be placed with its centre about 1 inch to the inner side of the middle of the clavicle, and should expose the space between the sterno-mastoid and trapezius muscles, the fibres of which are divided to a suitable extent if they abnormally encroach upon the bone. The skin, superficial fascia and nerves, with the platysma, are divided along the whole length of the incision, as also the deep fascia. The external jugular and other veins now come into view, often constituting a plexus, which may give the surgeon much trouble ; when possible, they should be gently drawn out of the way by means of blunt hooks, but if necessary they must be divided between ligatures. The cellular tissue is then further incised in the line of the wound, care being taken to avoid the transverse cervical and supra- scapular arteries, the former of which is above the line of operation, whilst the latter is hidden behind the clavicle, and should not appear. The posterior belly of the omohyoid, if seen at all, is drawn upwards. Various layers of fascia must be carefully cut or torn through until the nerves of the brachial plexus appear ; the finger can then readily define the scalene tubercle on the first rib. The subclavian vein is situated in front of the finger, but on a lower level, whilst the artery itself can be detected pulsating under the pulp of the finger between it and the rib. The cords of the brachial plexus are placed above and external to it, the lower cord passing down behind. The needle is insinuated from above downwards, and must be kept very close to the artery to prevent all possibility of including the lowest cord of the plexus. The operation in a thin patient may be easy, but in a stout subject, with a short thick neck and high clavicle, the greatest difficulty may be experienced in finding the vessel. The chief dangers arise from wounding the aneurismal sac, the pleural cavity, or the superficial veins, whilst the proximity of the cords of the brachial plexus must not be forgotten. Collateral Circulation. — Thoracic set : Branches of the aortic intercostals and internal mammary with thoracic branches of axillary. Scapular set : Suprascapular and posterior scapular with subscapular and its dorsalis branch in the venter or on the dorsum of scapula. Acromial set : Suprascapular with acromio-thoracic. The Internal Mammary Artery (Fig. 72, M) may be exposed and tied by dividing the intercostal aponeurosis and muscles for an inch or more from the outer edge of the sternum, from which margin it is distant about ^ inch. If the vessel has been divided, and the ends have retracted, it may be necessary to excise a portion of costal cartilage in order to secure both ends — a most necessary proceeding, owing to the freedom of the collateral circulation and the consequent liability to continued haemorrhage. Ligature of the Vertebral Artery has been undertaken for wounds, for secondary haemorrhage after ligature of the innominate and in the treatment of epilepsy, but without much permanent benefit in the last case. The opera- tion, though by no means easy, is usually successful as far as the immediate 288 A MANUAL OF SURGERY surgical procedure is concerned. An incision is made along the lower half o the posterior border of the sterno-mastoid (Fig. 72, V), the platysma and deep fascia divided, a few of the posterior fibres of the muscle itself incised if need be, and its belly drawn well forwards. The scalenus anticus muscle is clearly defined, together with the phrenic nerve. The interval between it and the longus colli muscle can now be demonstrated, with the ascending cervical artery lying upon it The anterior transverse process of the sixth cervical vertebra must be made out. Just below this the vertebral vessels are found entering the canal in the transverse process, and the vein, which is placed anteriorly, is drawn outwards to allow the needle to be passed from without inwards. A few sympathetic twigs are included in the ligature, and the resulting contraction of the pupil may (according to MacCormac) be looked upon as satisfactory evidence that the vertebral has been in reality secured. Ligature of the Thyroid Vessels is sometimes used as a means of arresting the growth of a goitre. The superior thyroid artery is tied by an operation similar to that for the external carotid. The incision along the anterior margin of the sterno- mastoid has its centre opposite the upper border of the thyroid cartilage ; the external carotid is defined, and the superior thyroid secured as it rises from it. The inferior thyroid artery is reached by an incision along the inner border of the sterno-mastoid, extending upwards from the clavicle for 3 inches. This muscle and the subjacent carotid sheath are drawn outwards, the sterno-hyoid and -thyroid usually needing to be divided. The transverse process of the sixth cervical vertebra is sought for, and the vessel found passing inwards immediately below. It is taken up just behind the carotid, and as far from the recurrent nerve as possible. The Axillary Artery is tied for punctured wounds of the axilla, as a distal operation for subclavian aneurism, occasionally for wounds of the palmar arch, and possibly for secondary haemorrhage from the brachial. For aneurism of the brachial, one would nowadays prefer extirpation of the sac if compres- sion fails. Two classical operations are described and practised in classes on operative surgery. 1. Ligature of the first part of the vessel is usually undertaken through a curved incision, with its concavity upwards, extending from the coracoid process to within 1 inch of the sterno-clavicular joint, and i, inch below the clavicle (Fig. 72, C). The clavicular origin of the pectoralis major is divided, and the costo-coracoid membrane exposed, and divided along the lower border of the subclavius muscle. Branches of the acromio-thoracic axis are displaced downwards, and the main trunk is exposed by a blunt dissector and forceps. The vein lies within and below, and the cords of the brachial plexus above and to the outer side. The needle is passed from below upwards. The divided muscular fibres should be subsequently sutured together. An incision which gives an unusually good approach and involves less division of muscular fibres is one which follows the lower border of the clavicle from its centre outwards to the coracoid process, and then turns down to lie over the interspace between the pectoralis major and deltoid muscles. This intersection is opened up and the outermost fibres of origin from the clavicle of the pectoralis are divided. The costo-coracoid membrane is thus exposed, and the cephalic vein will act as a guide to the vessels. 2. Ligature of the third part of the artery is performed from the axilla. The arm is fully abducted, and the surgeon stands between it and the body. An incision is made in the course of the vessel at the junction of the anterior and middle thirds of the space between the axillary folds (Fig. 74, A). The inner border of the coraco-brachialis muscle is clearly defined, and forms the first rallying-point ; it is drawn slightly outwards, and the median nerve, together with the musculo-cutaneous trunk , at once comes into view. On drawing these LIGATURE OF VESSELS inwards, the artery itself is seen, with the vein to the inner side, together with the internal cutaneous nerve. The needle is passed from the vein. Collateral Circulation. — If above the acromio-thoracic, the same as for the third part of the subclavian (q.v.). If above the subscapular and circumflex : Long thoracic and intercostals with thoracic branches of subscapular ; suprascapular and posterior scapular with scapular branches of subscapular ; suprascapular and acromio-thoracic with posterior circumflex in the deltoid. If below the circumflex, same as for ligature of brachial above the superior profunda — i.e., posterior circumflex with superior profunda in the deltoid. The Brachial Artery may need to be ligatured for haemorrhage from the palmar arches, or from a wound in the forearm or about the elbow, for aneurisms, or for arterio-venous wounds at the bend of the elbow. It may be tied in one of two places : i. At the Middle of the Arm. — The arm is held away from the side at a right angle, with the hand supine, but with no support beneath it, for fear of pushing forwards the triceps and displacing the vessel. The surgeon stands between the arm and the trunk. An incision 2 inches long is made in the line of the vessel along the inner border of the biceps muscle (Fig. 74, B), and the thin fascial investment of the limb divided. The inner edge of the muscle is clearly exposed, and by drawing it slightly forwards the median nerve is brought into view, and perhaps the basilic vein. The nerve, which is at this spot crossing the artery from without inwards, is drawn inwards, and the sss^^^j^^WII^K Fig. 74. — Incisions for tying the Arteries of the Arm. A, Third part of the axillary ; B, brachial ; C, brachial at the bend of the elbow ; D, middle third of radial ; G, middle third of ulnar ; E and F, lower thirds of radial and ulnar. sheath of the vessel found beneath it. The artery is separated from its venae comites, and the ligature passed and tied. The operation is by no means always an easy one, as there are many traps into which the beginner may fall. Thus the median nerve may cross behind the vessel instead of in front of it ; the basilic vein may lie over its situation, and be mistaken for it ; or there may be a high division, and two trunks, usually lying close together, must then be sought for instead of one. The most common mistake consists in not defining the biceps muscle, and in seeking for the artery behind its proper situation. 2. At the Bend of the Elbon*. — An oblique incision is made, about 2 inches long, parallel to the inner border of the biceps tendon, its lower end cor- responding to the crease of the elbow (Fig. 74, C). The wound should be placed at about an angle of forty-five degrees to the axis of the limb, and to the outside of, and nearly parallel to, the median basilic vein, which, if seen, must be drawn inwards. The bicipital fascia is now incised, and the artery with its venae comites exposed in the loose fat, the median nerve being well away on the inner side. The needle is passed from within outwards. Collateral Circulation.— If above the origin of the superior profunda, pos- terior circumflex in deltoid with ascending branches of superior profunda. 19 290 A MANUAL OF SURGERY If below the origin of the inferior profunda, the anastomoses around the elbow-joint. The Ulnar Artery rarely needs ligature except for palmar haemorrhage or direct wounds In the former case the artery can easily be secured just above the wrist, in the latter case by enlarging the original wound. The following stereotyped operations are described, but are more often seen in the examina- tion room or dead-house than in the operating theatre. It should be borne in mind that the artery curves inwards from the centre of the bend of the elbow to the radial side of the pisiform bone. The lower two-thirds of its course is indicated by a line drawn from the internal condyle of the humerus to the same spot below. 1. At the Wrist. — An incision about 1 inch in length is made directly upwards from the flexure of the wrist in the line of the vessel (Fig. 74, F). The deep fascia is opened ; the tendon of the flexor carpi ulnaris drawn to the inner side, and the vessels are then seen, accompanied by the nerve which lies to the ulnar side of the artery. If possible, the venae comites should be separated, and not included in the ligature. 2. In the Middle of the Forearm. — An incision is made along a line drawn from the anterior edge of the tip of the inner condyle to the radial side of the pisi- form bone (Fig. 74, G). The white line indicating the intermuscular septum between the flexor carpi ulnaris and flexor sublimis digitorum is then sought for and opened up; it is often very slightly marked, and may be difficult to distinguish. If the correct interspace has been opened, the surgeon is directed towards the ulnar, and readily finds the vessels under cover of the flexor carpi ulnaris, with the nerve lying a little way to the inner side. The most common mistake consists in getting too far tr. the radial side, and in separating various portions of the flexor sublimis, or in passing between it and the palmaris longus. Occasionally, even when the correct interspace has been entered, a beginner may pass beyond the vessels, and find himself between the flexor carpi ulnaris and the flexor profundus. The extreme upper limit of the ulnar artery can also be reached through an oblique incision extending along the upper border of the pronator teres, thus opening up the ante-cubital fossa, and exposing the bifurcation of the brachial. Radial Artery — The line of the vessel extends from the middle of the bend of the elbow to the interspace at the wrist between the flexor carpi radialis and the supinator longus. It then turns outwards, and may be felt beating in the space described by French anatomists as ' la tabatiere ' (or snuff-box), between the tendons of the extensor primi and secundi internodii muscles. 1. At the Back of the Wrist the vessel may be secured by opening up the above-mentioned intertendinous hollow, where the artery is found coursing onwards to the base of the first interosseous space. An oblique incision is made between the tendons, extending from the back of the styloid process of the radius to the base of the first metacarpal bone. The superficial radial vein is found beneath the skin, and a few twigs of the radial nerve. A deeper layer of fascia is then divided, passing between the tendons, and beneath it the artery is exposed, crossing the incision obliquely. The synovial sheaths accompanying the tendons should not be opened, or some limitation of the movements of the thumb may result. 2. Above the Wrist an incision is made in the line of the vessel (Fig. 74, E), which is found after division of the fascia between the supinator longus and flexor carpi radialis. The radial nerve has passed to the dorsum ere this, and if any nerve filaments are seen they are derived from the external cutaneous. A small superficial vein usually lies over the artery. 3. In the Middle or Upper Third of the Forearm an incision is made in the line of the vessel (Fig. 74, D), and the inner border of the supinator longus sought LIGATURE OF VESSELS 291 for and retracted. The vessels are found under cover of this structure, with the radial nerve to the outer side, though separated by an interval above. Ligature of the Abdominal Aorta* has been undertaken in fourteen instances for severe primary or secondary haemorrhage, or for diffuse inguinal or iliac aneurism, when no other method of treatment was practicable. All these cases have proved fatal, though one patient operated on by Monteiro in South America survived till the tenth day, whilst Keen's and Tillaux's lived forty- eight and thirty-nine days respectively. The fatal issue was in most instances due to septic contamination of the wound and secondary haemorrhage, and as the operation has certainly been successful in animals, it is possible that we may vet be able to chronicle a satisfactory result as a triumph of modern surgery. Two distinct plans of operation have been followed, viz., the trans-peritoneal, and the extra- or retro-peritoneal, but no one would attempt the latter nowa- days. The trans-peritoneal operation consists in opening the abdomen through an incision slightly to the left of the middle line, having the umbilicus on a level with its centre. The intestines are retracted on either side, and the posterior layer of the serous membrane covering the aorta carefully divided ; there is then no difficulty in passing a ligature around the vessel. Possibly the same precaution to prevent excessive backflow of blood would be advisable as in tying the innominate, viz., to secure one or both of the common iliac trunks in addition ; such would in no way interfere with the establishment of the collateral circulation. The Common Iliac Artery extends for a distance of 2 inches from the bifur- cation of the aorta opposite the left side of the body of the fourth lumbar vertebra to the front of the sacro-iliac synchondrosis. It may be reached, as the aorta, by two methods, the trans- and the retro-peritoneal. In the retro-peritoneal operation a curved incision (Fig. 75, A or B) is made through the abdominal parietes, somewhat similar to that for ligaturing the external iliac, but extending higher. The muscles and fascia transversalis are carefully divided, and the peritoneum, together with its contents, stripped up and held out of the way with a broad retractor. The ureter which crosses the artery is usually carried forwards with the peritoneum. The vessel is now sought for, carefully cleaned, and a ligature passed from right to left (of the patient) on both sides of the body, the vein lying behind the artery on the right side, and behind and internal to it on the left. The trans-peritoneal plan has already been undertaken with success, and will doubtless henceforth supersede all other methods. An incision is made in the median line with its centre a little below the umbilicus, the peritoneum opened, the intestines retracted, the vessel sought for and exposed bv an incision through the posterior layer of the parietal peritoneum, and a ligature passed and tied. The ureter which crosses the artery just above its bifurca- tion must be carefully avoided. Collateral Circulation after Ligature of Common Iliac Artery. — Blood reaches the external iliac and its branches by means of the anastomoses of the lumbar arteries with the circumflex iliac, and of the superior epigastric, lumbars, and intercostals with the superficial and deep epigastric. The internal iliac and its branches are supplied by the union of (a) the lumbar branches with the ilio-lumbar ; (b) the middle sacral with the lateral sacral ; (c) the retro-pubic anastomosis of the two obturator arteries ; and (. xvm | PLATE XX. Colles's Fracture: a Bad Case, with the Styloid Process of the Ulna torn off and much or i ward displacement ok hand. To follow Plato XIX.} INJURIES OF BONES— FRACTURES 463 the upper fragment is drawn forwards by the action of the biceps, and inwards by the pronator, assuming a position midway between pronation and supination ; the lower fragment is approximated to the ulna partly by the direct action of the pronator quadratus, partly by the supinator longus tilting the upper end inwards;, the hand is fully pronated looking downwards. Union to the ulna by callus thrown across the interosseous space is not unlikely to occur. Treat- ment by anterior and posterior splints may here be adopted, with a good interosseous pad interposed between the limb and the splints, the arm being placed midway between pronation and supination, and the hand fully adducted. 4. The Lower End of the Radius is broken with extreme fre- quency, constituting what is known as Colles's Fracture. This injury occurs most commonly in women of advanced years, although it may happen at any age or to either sex. It is almost invariably due to falls upon the outstretched palm, when the hand is completely pronated and extended. The line of fracture is placed about 1 inch from the wrist, though rather under than over this. It is usually transverse, but occasionally oblique in an antero-posterior direction, sloping from above down- wards and forwards, so that the fracture is nearer the wrist-joint in front than it is behind, and also not uncommonly oblique later- ally, slanting from without downwards and inwards (Plate XIX.). The displacement is somewhat complicated, (a) The lower fragment is carried backwards and a little upwards, a condition resulting from the direction of the violence, viz., a fall on the palm of the outstretched hand, the radius being thus compressed between the ground and the weight of the body, and yielding at what is evidently a weak spot ; this deformity is maintained by the action of the radial extensor muscles of the wrist, and often by impaction of the fragments, (b) From the fact that the main violence is received by the ball of the thumb, owing to the extreme pronation of the hand, the outer side of the lower fragment is displaced more than the inner, which, moreover, remains fixed to the ulna by the strong inferior radio-ulnar ligaments. This position is in part kept up by the tension of the extensors of the thumb and the supinator longus, but mainly by impaction of the fragments. The hand and carpus always follow the lower frag- ment, and hence the former becomes markedly abducted, causing the styloid process of the ulna to become unduly prominent, and lower than that of the radius, whereas it is normally placed on a slightly higher level. Occasionally the styloid process of the ulna is actually torn off, or the internal lateral ligament ruptured, allowing displacement outwards of the whole hand (Plate XX.). (c) The lower fragment is also rotated around a transverse axis, so that the lower articular surface looks backwards as well as downwards, a displacement due to the fact that in falling the force is directed, through the carpus, more to the posterior than 464 A MANUAL OF SURGERY to the anterior aspect of the bone, (d) The upper fragment is pronated and approximated to the ulna by the pronator quadratus muscle. The deformity produced by the fracture is therefore very characteristic. The hand is in a position of radial abduction, and usually pronated, with the fingers somewhat flexed (dinner-fork deformity). Three abnormal osseous projections are present : (i) The styloid process or head of the ulna is very marked, owing to the radial abduction of the hand (Fig. 147) ; (ii.) on the back of the wrist is a prominence which terminates abruptly above, caused by the projection of the lower fragment (Fig. 146) ; and (iii.) corresponding to this dorsal projection there is a well- marked depression on the palmar surface, and above it a less sharply-defined swelling, which gradually shelves into the fore- arm, due to the upper fragment. Pronation and supination are lost, and, as a rule, there is neither crepitus nor preternatural mobility, owing to impaction of the fragments. In doubtful cases Fig. 146. — Colles's Fracture : Fig. 147. — Colles's Fracture : Lateral View. Palmar View. (Tillmanns.) help in diagnosis may be obtained by observing the relative position of the two styloid processes ; normally, that of the radius is well below that of the ulna, but in cases of fracture the ulnar projection is below that of the radius. As already stated, the fracture is commonly impacted, the upper fragment being firmly driven into the cancellous tissue of the lower end ; excess of violence may, however, disimpact, but often at the expense of comminution of the lower fragment. Union is effected without difficulty, but the patient should always be warned at an early date to expect some deformity about the wrist, as well as considerable impairment in the subsequent mobility of the fingers and hand, owing partly to adhesions in the joint, partly to blood trickling down the tendon sheaths and fixing the tendons. Treatment. — To reduce the deformity, extension and manipula- tion are both needed. The patient should be seated on a chair, and the surgeon, standing in front, should grasp the hand firmly, using the right hand for fractures on the right side, and the left for those on that side. Counter-extension is made from the flexed elbow, and the hand is then forcibly extended and adducted ; INJURIES OF BONES— FRACTURES 465 disimpaction is thus brought about, and a little manipulation enables the fragments to be moulded into position. Many plans have been adopted in the application of splints for this fracture: (1) A piece of Gooch splint is perhaps the most simple and efficacious. It is shaped so as to cover the radius front and back as far as the middle line of the arm, and extends nearly from the elbow to the front and back of the knuckles of the index and middle fingers : its lower end is hollowed out in a horseshoe manner, so as not to reach beyond the end of the metacarpal bone of the thumb. This is well padded and firmly bandaged on ; it grasps the radius and steadies the hand in a position of adduction, without in any way interfering with the movements of the fingers. (2) Caw's splint (Fig. 148) consists of two shaped pieces of wood fitting the front and back of the radial side of the forearm, whilst to the palmar one is attached an oblique rod to be grasped by the fingers, and thus the hand and wrist are ^y ; /i/iiinii!!iiiiiiii/ii,iiiiiiff/ if/i/iiii/rf///,7////// Fig. 148. — Carh's Splint for Colles's Fracture of Left Hand. maintained in a position of adduction, whilst the fingers can be freely moved. (3) The Pistol splint consists of a straight portion fitted to the front of the forearm, whilst the handpiece is bent at an angle like the butt-end of a pistol. It may also be applied to the back of the forearm, together with a short straight splint on the palmar aspect reaching to the wrist. It keeps the hand and arm in excellent position, but is objectionable because the fingers are also restrained. If, however, it is shortened at the end of four or five days so as not to extend beyond the knuckles, it may be used without doing harm. (4) Two straight splints may be applied to the front and back of the forearm, which is kept mid- way between pronation and supination ; neither should extend beyond the knuckles, so that the fingers are free. The weight of the hand, when the arm is slung, keeps it in a position of adduc- tion. Union is usually firm enough in a fortnight to permit the removal of the splints, the arm being kept in a leather or gutta- percha support for some time longer. Massage and passive movement should be employed after the first week, and the fingers left free and exercised after the first day or two. 5. Separation of the Lower Epiphysis of the radius occurs in young 30 4 66 A MANUAL OF SURGERY people under twenty, and, when the lower fragment is displaced backwards, simulates somewhat closely a Colles's fracture. The lower end of the diaphysis projects anteriorly to a much greater extent, and, indeed, may protrude through the skin of the wrist, causing the fracture to become compound. The lower end of the ulna may also be involved in the accident, either the epiphysis being separated, or the shaft broken a little above. This condi- tion may also be mistaken for a backward dislocation of the wrist, but a diagnosis can be readily made by observing the relative position of the styloid processes to the carpal bones. Lateral displacement also occurs in some cases (Fig 149). Treatment is practically the same as for Colles's fracture. Fig. 149. — Skiagram of Displacement of Lower Epiphysis of Radius, and of the hand outwards. Should arrest of growth result from this accident, the hand retains its connection with the stunted radius, but the ulna con- tinues to grow downwards, and its lower end is found on the inner and posterior aspect of the carpus, which is pushed en bloc towards the radial side, but without any marked abduction. Fracture of both Bones of the Forearm may result from direct or indirect violence, but more commonly from the former. Any part of the bones may yield, but the middle and lower thirds are most frequently affected, owing to their greater exposure. The line of fracture may be transverse or oblique, and the dis- placement varies both with this and with the force employed. Occasionally both bones are broken close to the wrist by a fall PLATE XXL Fracture of both Bones of the Forearm, with Displacement outwards. To/ace p. 466.] INJURIES OF BONES— FRACTURES 467 on the palm of the hand (Plate XXL). The upper fragments are usually drawn together and pronated, whilst the lower end of the radius is drawn up by the supinator longus. The diagnosis of these fractures is very simple, since there is, as a rule, obvious deformity. Treatment consists in reduction by extension con- joined with manipulation, and the application of splints which will prevent cross-union of the bones. If the fracture is above the insertion of the pronator teres, the arm must be put up in full supination, as suggested for a similar fracture of the radius alone (p. 462), whilst below that spot the usual position midway between pronation and supination may be allowed. Union is generally complete in five or six weeks. Fractures of the Metacarpal Bones and Phalanges are not un- common, being due to direct violence, and hence usually trans- verse in direction. There is generally but little displacement, though occasionally the fragments may overlap. An oblique fracture sometimes occurs through the base of the first meta- carpal, separating the anterior portion, which remains in situ, whilst the rest of the shaft is drawn upwards and backwards. There is always a certain amount of localized swelling and tenderness in these fractures. The only treatment required is immobilization for a short time, and for the phalanges a small zinc splint moulded along the front of the finger acts admirably. Fractures of the Pelvis. Fractures of the pelvic bones are almost always the result of direct injury, such as blows, gunshot wounds, and railway, carriage, or cart accidents. For convenience they may be de- scribed under the following headings : 1. Fractures of the False Pelvis. — A portion of the crista ilii may be broken off, or the anterior or posterior spines separated, or merely a fissure in the bone produced. But little importance attaches to such conditions, as the displacement can never be great, although a portion of the crest may be drawn down by the glutei muscles, or the anterior superior spine displaced by the sartorius; in severer cases, when the bones are crushed and comminuted, the true pelvis is likely to be also affected, and more serious con- sequences may then arise. Considerable pain is always produced by these conditions, especially on any vigorous respiratory move- ments. Union occurs readily, all the treatment required being to keep the patient quiet in bed with the shoulders raised, and the legs supported to relax the muscles. A flannel bandage round the pelvis gives comfort and support. 2. Fracture of the True Pelvis is a much more serious accident. The line of fracture usually runs into the obturator foramen, and may detach both the horizontal ramus of the pubes and the ascending ramus of the ischium from the rest of the innominate 30—2 4 68 A MANUAL OF SURGERY Fig. 150. — Fracture of the Pelvis. (Bryant.) bone (Fig. 150). This is frequently conjoined v/ith a fracture through the sacro- iliac synchondrosis either on the same or opposite side, but more frequently the latter ; whilst a double fracture, front and back, may also occur at these, the weakest points. The cause of the posterior fracture is that, when the pelvic ring has yielded anteriorly from the violence, the con- tinued strain, whether di- rected from the front or from the sides, must necessarily fall on the part where the ilium is most closely connected with the sacrum, and the bones then give way rather than the unyielding and powerful sacro-iliac ligaments. The Symptoms are those of shock and pain in and around the pelvis, especially on movements of the legs or on coughing. There may be local ecchymosis, and tenderness over the pubic ramus, and the patient either cannot stand, or feels as if he were falling to pieces on attempting to do so. There is rarely any deformity, although occasionally such an occurrence is noted. Crepitus may be elicited on grasping the iliac bones, and moving them one on the other ; but such a method of investigation must be very sparingly indulged in. Complications frequently arise from injury to the internal viscera, especially the bladder, rectum, urethra, or vagina, as indicated by haemorrhage into or from these organs. An aseptic catheter should be passed as a routine proceeding, and if the urine is blood-stained, it is tied in. Treatment. — The patient should be moved with the greatest care, for fear of producing or increasing visceral complications. He is put to bed, and any obviously displaced fragments reduced, if practicable, possibly under an anaesthetic. A broad flannel bandage should be applied, the knees tied together, and a leather or poroplastic splint moulded to the pelvis. Visceral complica- tions must receive attention, as indicated elsewhere. Union may be expected in about six weeks, but the patient should be kept in bed for at least eight, and even then only allowed to get about on crutches, wearing a padded belt. 3. Fracture of the Acetabulum is of two types : either the posterior lip is broken off as a result of violence directed against it by the head of the femur, which is dislocated backwards by the same accident ; or a fall on the trochanter may cause a simple fissure extending into or across the cavity, or may resolve it into INJURIES OF BONES— FRACTURES 469 its three constituent elements, or may even drive the head of the bone into the pelvis. In the former case, the limb is in the position of a dorsal dislocation ; this can be reduced without difficulty, and possibly with crepitus, but manifests a great tendency to recur. Prolonged extension with a long splint is needed in such cases. In the latter class of injury a mere fissure of the acetabulum produces but few symptoms beyond a little pain and impairment of movement ; but if the head of the bone is driven into the pelvic cavity, the symptoms are much more serious, on account of the associated injuries to the viscera and the greater amount of violence employed. The case will resemble one of fracture of the neck of the femur, but there is usually only very slight mobility, and the head of the bone may be felt within the pelvis on rectal examination. An attempt should be made to free the head of the bone, and the case treated as one of fracture of the neck of the femur ; but a fatal issue is very likely to follow. 4. Fracture of the Tuber Ischii results from falls in the sitting position. The diagnosis is often obscure. 5. Fracture of the Sacrum is always due to direct violence of considerable severity, such as kicks, blows, or gunshot wounds. It is not unfrequently comminuted, and, from the associated injury to the lower sacral nerves, may result in loss of power of the bladder and rectum. In a transverse fracture, the lower fragment is usually displaced forwards, and may cause pressure upon the rectum ; irregularity in the shape of the bone may be detected from within (per rectum) or from without. Treatment. — The lower fragment should be replaced, if possible ; but considerable difficulty may be experienced in keeping it in position. A well- fitting pelvic band, with rest in bed, is probably all that is necessary. 6. Fractures of the Coccyx are by no means uncommon as a result of falls or blows, although its mobility often protects it from injury. Great pain is felt on walking, or on any movement which increases the intra-abdominal pressure, such as straining, coughing, defalcation, etc., since the coccygeus muscle which is attached to this bone forms part of the lower diaphragm of the abdomen. A rectal examination reveals preternatural mobility of the lower fragment, angular deformity, and perhaps crepitus. The Treatment consists in keeping the patient at rest until union has occurred ; it is impossible to apply any apparatus to correct the deformity. Sometimes the bone unites at an angle, causing much pain and discomfort, whilst difficulty in parturition may also arise from this cause. Excision of the bone is then required. The patient lies semi -prone with the legs slightly flexed or in the lithotomy position, and a longitudinal incision is made in the middle line. The apex and lateral margins of the bone are cleared, and the ligamentous tissues uniting it to the sacrum divided by the knife ; the bone is now laid hold of by sequestrum forceps, and its remaining attachments severed, due precautions 47o A MANUAL OF SURGERY being taken not to encroach on the rectum. Two or three stitches are inserted, and also a drainage-tube for a few hours; the dressing is secured in position by a T-bandage, but it is not common to obtain healing by first intention. The bowels should be confined for some days after the operation. Falls upon the coccyx, unaccompanied by fracture, sometimes give rise to a most severe and intractable type of neuralgia, known as coccydynia, which may quite prevent the patient from following his avocations. If all the usual sedatives fail in giving relief, the bone must be excised. Fractures of the Upper End of the Femur. i. Fractures of the Neck of the Femur are commonly divided into intra- and extra-capsular varieties, and, although this is by no means free from objections, yet it constitutes a useful working basis. The Intracapsular Fracture, or fracture near the head (Fig. 151), though it has occurred in children and adolescents, is almost in- variably met with in persons in advanced life, and especially in females. This is explained by the atrophic changes which take place in the cervix femoris of elderly people. The spaces between the bony cancelli are en- larged, and loaded with soft fat, whilst the ensheathing compact tissue is thinned, and the ' calcar femorale ' of Merkel (i.e., the process of thick cortical substance running from the lesser trochanter to the under part of the head) is atrophied. The neck of the bone is sometimes more horizontal than usual, and the head sinks below its usual position. Under such circumstances, it requires but little violence to produce a fracture, the direction of which varies ac- cording to the force applied. As a rule, the accident is due to some slight stumble or fall, such as slipping off the kerb or tripping upstairs ; the bone yields in con- sequence, and the patient falls to the ground. The line ol fracture may be transverse or oblique, and is mainly intra- capsular. Some of the fibres reflected from the under surface of the capsule to the head of the bone may remain untorn at first, but later on they may give way from inflammatory softening or injudicious manipulation or attempts to use the limb. The fracture is not usually impacted ; if, however, this condition should occur, the upper end of the neck is driven into the loose cancellous tissue of the head. The displacement is necessarily limited entirely to the lower fragment, which is drawn upwards by the glutei, recti, and hamstring muscles, and rotated outwards Pig. 151. — Intracapsu- lar Fracture of the Cervix Femoris. INJURIES OF BONES— FRACTURES 47' and somewhat backwards, so that the fractured surface looks almost directly forwards. The Method of Union in these cases depends to a large extent upon the general condition of the individual. If of a healthy temperament, and without any chronic pulmonary affection, so that he can be kept in the recumbent posture for six or eight weeks, bony union may certainly occur, in spite of the fact that at first synovial fluid finds its way between the fractured surfaces. The main process of repair takes place from the lower end, but little callus being formed from the head of the bone, the vascular supply being only just sufficient to maintain its vitality. If, however, the patient is feeble and weakly, and especially if the subject of chronic bronchitis and emphysema, the prognosis is by no means good, since hypostatic pneumonia and extensive bed- A B Fig. 152. — Extracapsular Fracture of Cervix Femoris. A, From behind, showing detachment of both trochanters ; B, on section, showing impaction of head and neck into base of trochanter, which also is detached, sores may carry him off during the short stay in bed, which is always necessary, in order to relieve the more urgent symptoms of pain. Bony union is never, under these circumstances, to be expected, and a loose fibrous union, or even a false joint, is the best that can be looked for, the patient henceforth walking with the assistance of a stick or crutch. The prognosis is, of course, much improved by the presence of impaction, and the fear of breaking this down must ever be in the mind of the examining surgeon ; whilst the integrity of bridges of periosteum and re- flected fibres from the capsule also improves the outlook. Extracapsular Fracture of the cervix femoris (fracture near the trochanter) is an absolute misnomer, since the capsule extends to the shaft of the bone along the anterior intertrochanteric line, and leaves no portion of the neck uncovered in this situation. 472 A MANUAL OF SURGERY The line of fracture is placed in front, either along the attachment of the capsule or within it, and is really only extracapsular behind ; sometimes, moreover, the shaft itself is considerably encroached on. The great trochanter is often involved in the fracture, being splintered or detached, and the lesser trochanter may be split off with a portion of the shaft, so that the bone is broken into at least three different fragments (Fig. 152). Mechanism. — This fracture is usually the result of direct violence acting transversely upon the trochanter major, as from a heavy fall upon the hip. The posterior part of the neck, being weaker than the anterior, first gives way, being more or less crushed and comminuted ; the whole neck then yields, and the severed head and neck are forcibly impacted into the junction of the trochanter and shaft (Fig. 152, B). The majority of these cases are thus primarily impacted, continuation of the violence producing dis- impaction, coupled either with detachment of one or both tro- chanters, or with comminution of the great trochanter. A similar result may follow from the inflammatory exudation causing a late separation of the impacted parts, or from injudicious manipulation. The displacement is much the same as in the former variety ; the upper fragment remains in statu quo, whilst the lower is drawn up and everted, only to a greater extent. Shortening may at first be slight, but is likely to increase at the end of a few days, as a result of disimpaction of the fragments, or from the yielding of the reflected fibres of the capsule, or from the tonic action of the muscles. Later on, moreover, the shorten- ing may again increase from a rapid absorption of the neck, which occasionally follows this accident, or is possibly due to the super- vention of chronic traumatic arthritis. The Signs and Symptoms of these two fractures may well be considered together, the points of similarity and contrast being in this way more effectually emphasized. (a) The signs of local trauma, viz., pain, bruising, and swelling, may be present in both ; but whilst slight in the intracapsular variety, they are very marked in the extracapsular. It must not be overlooked, however, that even in the former the patient may fall on the affected hip after the fracture has occurred, and thus cause a considerable amount of bruising. (b) Crepitus is evident in the unimpacted forms of each ; but it is unnecessary and, indeed, extremely unwise to elicit it by forcible manipulation, especially in the intracapsular variety. (c) Loss of power of the limb exists to a variable extent, and is perhaps more marked in the extracapsular form than in the intracapsular. Cases of the latter in which the patient was able to walk into hospital some days after the accident are not unknown, and are probably due to impaction. (d) Eversion is a most characteristic feature in both varieties, the limb lying absolutely helpless on its outer side. This displace- INJURIES OF BONES— FRACTURES 47; ment is accredited to the natural weight of the limb, to the greater fragility of the back of the cervix, causing it to be more com- minuted than the anterior surface, and, lastly, to the greater power of the external rotator muscles. Inversion has been met with in a few rare cases, but is probably due to the violence in the particular instance being directed from behind forwards, and to impaction of the fragments. (e) Shortening is slight in the early stage of intracapsular, and much greater in the extracapsular, fractures. In the latter case the shortening usually attains its maximum — viz., il to 2h, or even 3 inches — at once ; but such is not always the case in the former. It is indicated by displacement of the trochanter upwards, due allowance being made for the position of the limb as regards abduction or adduction. (/) The position of the great trochanter is of the greatest im- Fig. 153. — Nelaton's Line and Bryant's Measurement for ascertaining Position of Great Trochanter. portance. It is raised above its ordinary level and everted ; it is approximated to the middle line of the body and to the anterior superior iliac spine, and rotates in the arc of a smaller circle than usual, the radius being the thickness of the trochanter alone, instead of including also the length of the neck. The demonstra- tion of this position is most important, and, amongst others, the following tests are employed : Nelaton's line (Fig. 153) is one drawn from the anterior superior spine to the most prominent point of the tuber ischii (AB). The centre of this (D) corresponds to the top of the great trochanter, if the limb is placed in the axis of the body ; but if either abduc- tion or adduction is present, the top is situated slightly above or 474 A MANUAL OF SURGERY below the line. Definite elevation of the bone above the line indicates shortening of the limb due to dislocation backwards, fracture of the neck, or absorption of the neck from disease. Bryant's Test Line (Fig. 153). — In this the patient lies flat on a horizontal couch, and a vertical line (AC) is drawn from the anterior superior spine ; a thin wooden rod held against the side answers this purpose admirably. The perpendicular distance of the top of the great trochanter from the line (CD) is compared with a similar measurement on the opposite side ; definite shortening may thus be discovered. Morris's bitrochanteric test indicates the amount of inward dis- placement. It is conducted by measuring the distance between the outer surfaces of the trochanters and the middle line of the body by means of a rod graduated from the centre, along which two pointers work outwards. Shortening in this direction will also be observed in most dislocations of the hip-joint. One other change in the great trochanter may be noted in the extracapsular form of fracture, which can be utilized as a useful diagnostic feature between it and the intracapsular variety, viz., the great amount of thickening of the process which is always pro- duced, owing to the excessive development of callus. In the intracapsular variety it is rarely fissured or injured, and therefore no thickening occurs. (g) Lastly, relaxation of the fascia between the crest of the ilium and the great trochanter (that is, of the upper part of the ilio- tibial band) is given as a characteristic feature of these fractures. Diagnosis. — Simple unimpacted fractures are readily detected, and there can be but little difficulty in distinguishing the two forms, either from one another or from other injuries. The fact that an impacted fracture has occurred can also be easily made out as a rule, the pain, eversion, and shortening sufficing to indicate its existence ; but it is often very difficult to say which of the two forms of fracture is present, especially if the surgeon is not called till late in the case. The character of the accident and the age of the patient must be taken into account, whilst the existence of Assuring or thickening of the trochanter, or an excessive amount of shortening, may indicate that the lesion has been extracapsular. A severe contusion of the hip, which may be associated with marked eversion, is known from a fracture by the absence of shortening and crepitus ; there is no displacement of the trochanter, which rotates in a normal manner. The shortening which sometimes follows, owing to subsequent atrophy of the neck, may, however, complicate matters. In a dislocation the head of the bone can be felt in an abnormal position, and hence no difficulty should be experienced in its recognition. In chronic osteo-arthritis of the hip with antecedent shortening and marked bony crepitus, there may be no history of accident, and no acute eversion, pain, or loss of power ; possibly the existence of similar disease in other joints INJURIES OF BONES— FRACTURES 475 may assist the surgeon, whilst osteo-arthritis of the hip usually results in prominence of the trochanter, and not in flattening, as occurs after fracture. Moreover, the fascia above the trochanter is never relaxed in osteo-arthritis, always in fractures. It must not be forgotten that, after an intracapsular fracture, the patient may fall, not on the injured side, but on the sound thigh, and cases have been known where the surgeon's attention was directed to the wrong limb owing to the amount of bruising there manifested. The Treatment of intracapsular fractures must depend in great measure, as already stated, upon the individual. If old, weakly, and with a tendency to chronic bronchitis, long confinement to bed would have a most deleterious, if not fatal, effect. In such cases the limb is put at rest for a few days between sandbags, and cooling lotions applied. A Thomas's splint should be fitted as early as possible, and the patient encouraged to get about on crutches. Fig. 154.- -Liston's Splint padded and applied. a. Perineal band. In a healthy individual with good physique, where bony union may be expected, the patient is kept at rest in bed for six or eight weeks, by means of Liston's splint (Fig. 154). This needs careful adjustment, but is satisfactory in its results when properly applied. It should reach from the axilla to about 6 inches below the ankle, and is fixed to the leg and body either by bandages, or much better by two broad sheets, which first firmly envelop the splint, and are then passed round the body, and finally secured by pins to the portion surrounding the splint. Carefully padded poroplastic foot-pieces are placed on either side of the ankle so as to diffuse the pressure, and a handkerchief passed round the foot, and through the prongs at the end of the splint, fixes it in the desired position. A well-padded perineal band is next applied, taking its purchase from the tuber ischii, and with its free ends passed through the two holes at the upper extremity of the splint ; by tightening and tying these two together, the upper end of the splint is steadied. Extension of the limb is obtained by an elastic 476 A MANUAL OF SURGERY accumulator, or by weight and pulley acting from the knee in the usual way. Finally, the sheets or bandages are adjusted, and the lower end prevented from moving laterally or rotating by slipping it into a slot between two rectangular plates of metal screwed to a substantial wooden base, which rests on the bed. The handker- chief and perineal band will need occasional tightening to maintain the required position, and the latter must be renewed from time to time for purposes of cleanliness, and the parts well powdered with boric acid. At the end of six weeks or so the pelvis should be encased in poroplastic material or plaster of Paris, and the patient allowed to get about on crutches, or a Thomas's splint applied. No attempt should be made to disimpact fractures in old people ; rest and quiet are maintained by applying a long splint without extension, and bony union usually follows. In other cases it may suffice to simply lay the limb on a bed between sandbags, and to make extension from the foot. The leg is first swathed with a boracic lint bandage, and then a piece of broad adhesive plaster is applied on either side of the limb, reach- ing nearly as high as or above the knee, and with a loose stirrup 4 or 5 inches long below the foot ; the plaster is secured by one or two strips of strapping f inch wide wound obliquely round the limb above and below, and by a calico bandage. In the stirrup a cross-piece of wood, rather broader than the ankle, is inserted, and a knotted cord carried through a hole in it. The cord is passed over a pulley fixed to the end of the bed, and to its end is attached a weight, varying with the requirements of the case ; the lower portion of the bed is usually raised by placing the legs on blocks, so as to utilize the weight of the body as a counter-extending force. As the continuous application of a heavy weight may stretch the ligaments of the knee joint, it is usually advisable to distribute a part of the traction above the knee. Hodgen's splint, as described below, may also be used in these cases. Treatment of Extracapsular Fracture. — The long splint with extension will sometimes suffice for this condition, good bony union usually occurring, though with some shortening. In other cases it may be advisable to make extension from the knee, and to keep the limb slightly flexed, as on a double inclined plane. Probably treatment is best carried out by the use of the splint intro- duced by Dr. Hodgen, of St. Louis, U.S.A., the value of which was first demonstrated in this country in the theatre of Guy's Hospital by the inventor in 1879. For our description of it we are indebted to Mr. Golding Bird. It is made of stout iron wire, quite rigid, and is in the form of the letter U, the outer limb reaching from the anterior superior spine to 3 inches below the instep, and the inner from the adductor longus tendon to the same spot, where the two limbs unite in a crossbar 3 inches in width. INJURIES OF BONES— FRACTURES 477 The sides taper with the limb, and should be f inch further apart than the diameter of the limb at any point. At the upper end the bars are united by an arch of the same material, which is placed on the slant, and should correspond to Poupart's ligament ; two simi'ar arches are placed at equal points lower down. The splint is bent at the knee to about an angle of 130 . Before applying the splint, an ordinary extension stirrup should be attached to the limb, and a piece of wood introduced therein wide enough to take any pressure off the malleoli ; to the wood is tied a piece of stout cord. Strips of house flannel, about 7 inches wide, are then cut and arranged beneath the limb at right angles to its direction, each one overlapping the next ; the length of the strips should be rather more than the circumference of the limb at the Fig. 155. — Hodgen'3 Splint applied. spot to which each is to be applied. The splint is then adjusted, the top of the outer bar resting against the anterior superior spine, and the inner bar against the adductor tendon. The strips of flannel are then raised in succession, and, being lapped over the bar, are pinned or stitched there, so that when completed the limb lies in a flannel trough, from which only the upper surface projects, and there should be an interval of fully an inch between Poupart's ligament and the upper crossbar. The short cord already mentioned as being attached to the stirrup is then securely tied to the lower end of the splint. Cords are now fixed to the hooks, two of which are soldered to each side of the splint, the lengths of the cords being such that, if they were raised and made taut with the finger, the finger would be about 478 A MANUAL OF SURGERY 8 or 10 inches above the splint. The two cords are then brought together over the limb, and to them is tied another stout cord, which passes over a pulley attached to a vertical post at the end of the bed, and is weighted to a sufficient extent. The angle required to make satisfactory extension is determined partly by the position of the limb, partly by the sensations of the patient. The limb when the weight is applied should lie free of the bed, even to its extreme upper limit. No bandages are required ; the limb lies in the obliquely-set flannel trough, which is maintained in position by its friction against the limb ; the splint itself is pulled upon by the extending force, and this is transmitted to the limb through the stirrup cord attached to the lower end of the splint. If correctly applied, this stirrup cord is taut ' like a harp string '; any slipping of the extension or of the apparatus is indicated by laxity of this cord, and involves readjustment. Some authorities, however, recommend that the thigh should be enclosed in Gooch splinting, a narrow piece in front between the bars, and a broader piece behind encircling the limb. These are well padded and bandaged on, the bandages extending over the whole length of the apparatus ; finally, starch is rubbed in so as to fix it more firmly. When impaction has occurred in young and active individuals, it is quite justifiable to give an anaesthetic, and forcibly break it down, so as to prevent subsequent shortening. 2. Fracture of the Great Trochanter is very rare, and always due to direct violence ; in the young it occurs as an epiphyseal lesion. The trochanter, or a portion of it, is entirely separated from the rest of the bone without any loss of the continuity of the shaft. Independent movement of the fragment with crepitus is usually obtainable ; and if the displacement is at all marked, an operation to fix it by means of a plated screw or ivory peg should be undertaken. 3. Fracture through the Great Trochanter (the per-trochantcric fracture of Kocher) closely resembles the extracapsular fracture, the lesion running from the inner and under part of the neck obliquely upwards and forwards through the base of the trochanter. The lower fragment, including the lesser trochanter, is drawn upwards and backwards towards the sciatic notch, and forms a projecting mass behind, somewhat simulating a dislocation ; the tip of the trochanter can, however, be felt separately, not moving with the shaft. Such cases may be treated by extension with the long splint, or perhaps better by Hodgen's apparatus. 4. Separation of the Upper Epiphysis of the Femur. — The upper cartilaginous end of the femur in infants includes not only the head, but also both trochanters, and there is no case on record of complete detachment of this portion. Ossific centres early appear for each of these three projections, and by the rapid growth upwards of the shaft, they are separated from each other by the INJURIES OF BONES— FRACTURES 479 fourth year, the neck thus being really constituted as an outgrowth of the shaft. The epiphysis of the head has been completely detached in a considerable number of cases, but the accident is not so common as in the humerus, owing to the protection given by the depth of the acetabulum. The phenomena closely simulate those of an intracapsular fracture, but are less obvious. Impair- Fig. 157.- — Fracture of Lower Third of Femur, showing Displacement of Lower Fragment Backwards (From Gray's 'Anatomy.') Fig. 156. — Fracture of Utper Third of Femur, showing Displacement of Bone. (From Gray's 'Anatomy.') ment of growth may follow, and possibly the shape of the head and neck may be so altered subsequently as to simulate the con- dition known as coxa vara. Treatment of the lesion is by exten- sion, and possibly the use of the long splint. Fractures of the Shaft of the Femur are extremely common accidents, in spite of the apparent strength of the bone. Any part may be involved, particularly the centre, whilst they occur at the 4 8o A MANUAL OF SURGERY lower end more frequently than at the upper. In the latter situa- tion they are usually due to indirect violence, whilst at the lower end they generally result from direct injury ; either form of violence may lead to a fracture about the middle of the bone. In almost every case displacement occurs, the direction and amount of which depends not only on the line of fracture, but also on the situation. In the upper third (Fig. 156), the small upper fragment is usually tilted forwards by the ilio- psoas, and abducted and everted by the gluteus minimus and external rotators ; whilst the lower fragment is drawn upwards and to the inner side of the upper by the hamstrings and adductor muscles, marked eversion also resulting partly from the weight of the foot, and partly from the action of the adductors ; but such a com- plicated displacement is not always present. In the middle third, if due to direct violence, the line of fracture slants from above downwards and backwards, causing a simple over-riding of the fragments, or an angular deformity. The lower fragment is drawn upwards and inwards, either in front of or behind the upper fragment, and is usually everted. The upper fragment is sometimes tilted forwards. If due to direct violence, the fracture is more often transverse, and any form of displace- ment may then occur. In the lower third the fractures often arise from direct force, and are transverse ; the lower fragment may then be tilted backwards by the gastrocnemii muscles, and compress or rupture the popliteal vessels, perhaps causing gangrene (Fig. 157). Oblique fractures from indirect violence, sloping from above downwards and for- wards, are also met with ; the upper fragment is driven into the substance of the quadriceps muscle and may become fixed in it, projecting immediately beneath the skin, whilst the lower frag- ment is drawn up behind. If such a case is left unreduced, ununited fracture is likely to ensue ; the knee-joint is generally penetrated by the lower end of the upper fragment. Treatment. — In the upper third, where the upper fragment is tilted forwards, constituting a projection under the skin, and when it is too short to be controlled by any splint, reduction of the deformity is accomplished by flexing the thigh, and making extension from the knee, the lower fragment being thus brought into the same axis as the upper. Manipulation will usually correct any lateral displacement. The limb must be confined in this position by some form of inclined plane, such as a Mac- intyre's splint, with a long thigh-piece, and with small straight wooden splints or a piece of Gooch's splinting fixed, if necessary, to the front and outer sides of the limb, over the seat of fracture. The splint is slung at the knee, the foot-piece being fixed to blocks of wood, a little lower than the level of the knee. If these pre- cautions are not taken, an ununited fracture, with the upper frag- ment in front of the lower, is likely to occur. Hodgen's apparatus also answers admirably in these cases. INJURIES OF BONES— FRACTURES 481 In the middle third of the thigh, where the upper fragment can be controlled by splints, shortening is prevented by simple, exten- sion (p. 476), the thigh being surrounded by pieces of Gooch's splinting, which grasp the muscles and keep the parts at rest. The limb is then placed between sandbags, or secured on a Liston's splint. Where the fracture is oblique, with a good deal of tendency to overlap, Hodgen's apparatus should be utilized. In the lower third, if there is any tendency to displacement of the lower fragment backwards, a Macintyre's splint, with a long thigh-piece and the knee well flexed, may sometimes be employed, together with a short anterior thigh-piece of Gooch's splinting; but if the upper fragment projects anteriorly beneath the skin through the quadriceps, operation alone holds out any prospect of bringing the parts into apposition, the muscular fibres being divided sufficiently to allow the projecting end of the bone to be replaced, and if necessary wired or pegged. In other cases the ordinary long splint or Hodgen's will be required. In children, Bryant's plan of treatment is excellent ; it consists in slinging the limb from a crossbar at right angles to the body, with or without a back-splint reaching from the heel to the nates and short lateral splints, thus obtaining extension by utilizing the weight of the body, whilst the bandages, etc., are kept from being soiled. If a long splint is used for children, a double one (e.g., Hamilton's splint) with a crossbar below is the best. Plaster of Paris or starch bandages may be early applied in adults, but only in the later stages in young children, as they are difficult to keep clean. Fractures of the Lower End of the Femur. 1. Transverse Supracondyloid Fracture is practically identical with that involving the lower third of the femur ; the lower frag- ment is rotated backwards by the action of the gastrocnemii, thus endangering the integrity of the popliteal vessels, and predisposing to non-union, if the deformity is overlooked. 2. T- or Y-shaped Fracture of the Condyles. — In this a trans- verse fracture is complicated by a fissure, which runs into the joint, separating the two condyles. The symptoms are much the same as the above, but the joint is distended with blood, the bone may feel broader than usual, and crepitus may be detected. The Treatment is the same as for transverse fracture. 3. Separation of either Condyle always results from direct violence, the line of fracture being oblique. There is no shorten- ing, but the leg may be deflected towards the side injured, and the joint is distended with blood. It may move separately from the shaft, and give rise to crepitus. Treatment. — Reposition is easily effected when the limb is slightly flexed, and it is best put up in this position. Occasionally a small portion of the condyle may be detached 3i 4 82 A MANUAL OF SURGERY and lie loose in the knee-joint ; when the immediate symptoms due to- the injury have subsided, the signs of a foreign body in the joint may become evident. 4. The Lower Epiphysis of the Femur is separated from the shaft in young people; it is net a very rare accident, and closely simulates in its signs those of a transverse fracture, even occasion- ing gangrene in some cases. The epiphysis is generally displaced forwards by the traction of the quadriceps on the tibia, and the vessels are then compressed by the lower end of the diaphysis. Suppuration occurs in a fair proportion of the cases. This con- dition has been mistaken for disease of the knee-joint. Treat- ment. — Reduction is effected by an assistant making traction on the tibia in the line of the limb so as to stretch the quadriceps ; then the thigh is gradually flexed by the surgeon, standing above and with both hands clasped beneath it. The epiphysis is by this means restored to its normal position, and the limb is kept flexed by a bandage at about an angle of 6o°, and laid on its outer side with an icebag applied. Passive movement is carefully com- menced in a fortnight. 5. Longitudinal and Spiral Fissures are met with in the femur, running down to the knee-joint, but causing no characteristic symptoms beyond pain and haemarthrosis. Early passive move ment is necessary to prevent impairment of function. Fractures ef the Patella. The patella is broken in two distinct ways, viz., by muscular force and by direct violence, and the conditions produced are so different that a separate description is necessary. 1. Fractures hy direct violence may traverse the bone in any direction, but are most often vertical or star-shaped, and possibly comminuted. They are frequently incomplete, i.e., mere fissures of the front of the bone, and as a rule the fibrous aponeurosis or capsule covering it is uninjured, thereby preventing any displace- ment of fragments. There is a good deal of subcutaneous bruising, and perhaps some effusion into the joint, whilst on careful palpa- tion the fissure may be detected. Crepitus can be obtained if the fracture is complete. Treatment consists in keeping the limb at rest on a back-splint, and perhaps applying evaporating lotions. Passive movements must be commenced early where there has been much effusion into the joint. 2. Fractures due to muscular force constitute a very different class of injury, since they are always transverse, usually complete, and also involve the fibrous aponeurosis, so that considerable dis- placement occurs. Mechanism. — When the knee is semi-flexed, the patella is poised upon the front of the condyles of the femur, resting upon the middle of its articular surface ; in this position any sudden INJURIES OF BONES— FRACTURES 483 and violent contraction of the quadriceps, as in attempting to recover one's equilibrium after having slipped, takes the hone at a disadvantage, and may succeed in snapping it. Possibly in some people there is a predisposing weakness, as cases are not rare in which the other bone yields subsequently, although perfect functional repair has been obtained in that first broken. The fragments are often almost equal in size (Fig. 158), but may vary widely ; and either of them may be again divided vertically, or comminuted. The Signs of this fracture are very evident, consisting of loss of power in the limb, pain, distension of the joint with blood, and separation of the fragments, which can be readily felt and some- times brought into apposition with crepitus (Figs. 158 and 159). Fig. 158. — Fracture of Patella, and Separation of Fragments. (From Gray's ' Anatomy.') Fig 159 — Appearancf of Knee after Fracture of Patella. This displacement, at first due to muscular action, is maintained by the effusion of blood, as also later by synovial exudation. Union by bone is rarely obtained under ordinary circumstances, a fact explained partly by the separation of the fragments, and partly by the carrying in of loose tags of the fibrous aponeurosis or capsule, which yields at a different level to the bone. Fibrous union is the usual result, and when this is short and strong, it may be quite satisfactory ; but more commonly the bond of union yields when the limb is used, so that the two fragments are once again separated, merely a bridge of fibrous tissue intervening, the joint being often very weak in consequence. The Treatment of these cases has been a matter of much discussion, and many plans have been adopted, which may 31 — 2 484 A MANUAL OF SURGERY be grouped under three headings, viz., treatment by retentive apparatus, by subcutaneous operation, or by the open method. 1. Simple retentive apparatus may be employed in cases where the fragments are not widely separated, and can be readily brought into contact and maintained in apposition. Some surgeons depend mainly upon plaster of Paris to effect this. If there is but little effusion, the limb is extended, swathed in cotton-wool and a flannel bandage, and over this the plaster casing is applied. As the apparatus becomes loose from muscular atrophy, it will need readjustment. The patient is kept in bed for three or four weeks, but the plaster is retained for as many months, and after that a knee support, such as the Middlesex splint (vide infra), is kept on till twelve months have elapsed. Where there is much effusion after the accident, the limb is placed on a back-splint and kept cool by ice or evaporating lotion, until the fluid has been absorbed ; or the joint may be aspirated in order to hasten matters. The plaster is then applied, and the same routine followed. The chief objection to this plan is the enclosure of the limb in the plaster case, so that the muscles and joint cannot easily be got at for purposes of massage. In the so-called Middlesex plan of treatment a large piece of moleskin plaster is placed over the front and sides of the extensor surface of the thigh, reaching halfway up to the groin, and terminat- ing below in two lateral elongated ends or tags, to which elastic traction is applied. The limb is put on a back-splint, with a foot- piece, beneath which the elastic accumulator is firmly tied. Removal of the effusion in the joint may be hastened by the use of the aspirator. At the end of about six weeks the patient is allowed to get about in a plaster of Paris casing, and then, about three months after the accident, a special knee-splint is substituted, which allows of only a small amount of mobility at first, but, by filing away a stop, this can be gradually increased, until a full range of movement is permitted. In this method of treatment it is probable that only fibrous union is obtained. 2. To ensure more accurate apposition and a firmer union, and yet to avoid the risks necessarily associated with laying the joint open, various subcutaneous operations have been adopted, (a) Barker recommends antero -posterior suture of the bone (Fig. 160). An opening is made with a tenotomy knife into the joint just below the lower segment, through which any effused blood or synovia can be squeezed, and along which a curved hernia needle is passed, traversing the articulation from below upwards, and emerging through the skin above the upper fragment. A piece of sterilized silver wire is then carried back under the bone. The needle is again inserted at the same spot below, and carried in front of the bone under the skin, emerging at the same point above. The upper end of the wire is threaded through it, and by this means brought out at the lower opening. The bone is thus encircled, INJURIES OF BONES— FRACTURES 485 and by tightening and twisting the wire the fragments are brought into apposition. The ends are cut off and pushed back under the skin. The punctures are treated antiseptically, and the limb placed on a back-splint for a week or so, when passive movement is commenced, the patient being allowed to walk about at the end of the second week, and discarding all apparatus at the end of five weeks, (b) Circumferential suture (introduced originally by Butcher, of Liverpool) is also practised (Fig. t6i), the wire in this case passing round the bone from side to side. A somewhat longer period of after-treatment is needed in these cases, (c) Mayo Robson, of Leeds, inserts knitting needles through the muscle and tendon above and below the fragments, and draws them together by elastic bands passed over the ends (Fig. 162). Necessarily, a certain element of risk is admitted in any of these subcutaneous operations, and the surgeon has to ask himself whether he is doing the best for his patient by utilizing such proceedings, granting that it is advisable to interfere at all. Personally, we are of opinion that, if it be justifiable to incur any risk, it is best to proceed by the open method, since in none of Fig. 160. — Barker's Method of Sub- cutaneous Suture after Fracture of Patella. Fig. 161. — Circumferen- tial Suture for Frac- ture of Patella. Fig. 162. — Mayo Rob- son's Method of dealing with frac- TURED Patella. the others can the fragments be brought into accurate apposition, owing to the impossibility of removing the interposed portion of fibrous capsule, which is always curled in over one of the broken surfaces, whilst the joint cavity cannot be cleared of the blood- clot which may have collected within it. Impressed by the confidence derived from a thorough and efficient application of aseptic principles, we cannot but conclude that, if it is desirable to do more in a case of fractured patella than apply mere retentive apparatus, the patient's welfare is best consulted by adopting — 3. The open plan of treatment, advocated and perfected by Lord Lister. It consists in freely exposing the interior of the articula- tion, clearing the joint of all blood-clot, removing all tags of fascia or aponeurosis, and wiring the fragments securely together. 486 A MANUAL OF SURGICKY No surgeon should attempt this operation unless well assisted and thoroughly an fait with the details of antiseptic work. At King's College Hospital this practice is now almost exclusively followed, and the results, at any rate in the more recent cases, are most satisfactory, no instance of serious mischief from the opera- tion having arisen for the last fifteen years or more. A longi- tudinal incision is sometimes adopted, although a horseshoe- shaped flap is more frequently dissected up or down, exposing the bone. All blood-clot is removed, and the fractured surfaces cleared of all clot and fibrous shreds, which are very often adherent. Tracks for the wire sutures are now made by a bradawl, extending from the upper or lower end through the centre of the bone, so as to emerge on the fractured surface just in front of the articular cartilage (Fig. 163); should the awl emerge at different levels on the faces of the fragments, cartilage or bone must be chipped away to make a channel in which the wire may lie, so that the two fragments are exactly level, with no inequality of the articular cartilage. A sterilized silver wire of suitable thickness is then passed ; the bones are brought into apposition, and the wire twisted into a knot or loop, which is hammered or pressed down into the periosteum, so as to keep it from projecting under the skin and causing irri- tation. A second wire is sometimes needed in order to prevent rotation of the fragments. The wound is closed, and the limb kept on a Gooch's splint for eight days, when passive movement is commenced, and by the end of a fortnight the patient is allowed to walk in the simpler cases ; but in complicated frac- tures and in elderly people it is advisable to keep the limb immobilized for a longer period. It is perhaps advisable not to undertake this operation immediately after the accident. The limb should be kept at rest on a back-splint, and an icebag applied for a week or ten days, so as to allow the joint to recover from the effects of the injury it has sustained ; there is then much less risk of septic complications. In old cases, where the fibrous union has stretched and the utility of the limb is seriously impaired, the open operation holds out the only hope of helping the patient, although it is always a matter of considerable difficulty. The fibrous tissue must be dissected away, and the ends of the bones freshened, if need be, with the saw. To obtain apposition, the upper fragment must be freely detached from the femoral condyles, to which it is very often adherent, and the rectus muscle, which is secondarily contracted, may need to be partially divided. The limb should be well raised Fig. 163. — Position of Silver Wire in Open Operation for Fractured Patella. INJURIES OF BONES— FRACTURES 4S7 to relax the quadriceps and thus diminish tension on the bond of union, and lowered inch by inch on succeeding days. The muscle is thus stretched to accommodate itself to the altered conditions. If the fragments cannot be absolutely brought together, the same treatment may be adopted, and the patient allowed to get about with silver wires between the fragments ; the quadriceps is stretched by this means, and a subsequent operation may prove successful in gaining bony union. Fractures of the Leg. In the leg fractures may be due to direct or indirect violence, and may involve either the tibia or fibula alone, or both bones. Fractures of the Tibia alone. — Several varieties are described. (a) The upper end is usually broken as a result of direct violence, the line of fracture being transverse ; it is by no means a common accident. The characteristic features are not always very evident at first, since considerable swelling and ecchymosis are produced. Occasionally as a result of falls on the heel a T-shaped fracture occurs, the tuberosities being broken off and the upper end of the shaft impacted into one or both of them. A few cases of vertical separation of one of the tuberosities alone are also on record. Treatment consists in placing the limb upon a back-splint, e.g., Macintyre's, with the knee bent, and, as a rule, satisfactory union ensues, though possibly with some distortion, (b) Fracture of the shaft of the tibia, apart from the fibula, is usually caused by direct violence. It is transverse in the upper part of the bone, and oblique below (Plate X.). The fracture is diagnosed by feeling an inequality on running the fingers along the shin, together with pain at this spot on firmly grasping the bones above and below. There is often but little displacement, since the fibula acts as a splint, but the lower end of the upper fragment, which is usually pointed, is tilted forwards by the action of the quadriceps and may pierce the skin. The treatment consists in the application of back or side splints (Cline's) for a few days until the swelling has gone down, and then the limb may be put up in plaster. If the bone has been comminuted, treatment will be more protracted, (c) The internal malleolus is occasionally separated as the result of direct injury, apart from any other osseous lesions, constituting what is known as ' Wagstaffe's fracture.' There is comparatively little displacement, but the malleolus is loose, and crepitus can usually be obtained on moving it backwards and forwards. Union by fibrous or osseous tissue ensues, but usually in a more or less abnormal position, in consequence of which the integrity of the ankle-joint is disturbed, and weakness or lameness may follow.' Treatment consists in the application of lateral splints. If there is any difficulty in keeping the parts in apposition, an incision should be made, and the malleolus wired or pegged to the tibia. 488 A MANUAL OF SURGERY Fractures of the Fibula alone are by no means uncommon, usually occurring as a result of direct violence. There is no displacement or deformity, but the patient complains of pain localized to some particular spot, and this can usually be elicited by grasping the bones above and below, and compressing them laterally ('springing' the fibula). Sometimes the diagnosis is extremely uncertain, and then the X rays prove useful. Treat- ment consists in immobilizing the limb in a plaster case. Fracture of both Tibia and Fibula is a very common accident, due to both direct and indirect violence ; if to direct violence any part may be injured, both bones yielding at the same level; but if in consequence of an indirect injury, the tibia usually gives way at its weakest part, viz., at the junction of its middle and lower thirds, and the fibula at a slightly higher level. The fractures are often oblique, running in any direction according to the character of the violence, although the obliquity is most frequently directed downwards, forwards, and inwards. The lower fragment is gener- ally drawn upwards on account of the contraction of the powerful calf muscles, and often rotated outwards from the weight of the foot ; hence there is well-marked shortening, which can usually be overcome by traction. The ordinary characteristics of a fracture are very evident, and but little difficulty can ever be experienced in making a diagnosis. The fracture is likely to become compound when due to indirect violence, owing to the sharp end of the oblique fragment of the tibia, usually the upper, piercing the skin. Skiagraphy is exceedingly useful in enabling one to decide as to the character of the lesion, and the skiagrams should be taken both from the front and from the side, as the appearances are often very different (compare Plates XXII. and XXIII.). The fracture of the tibia has been proved by skiagraphy to be frequently of the bec-de-fiute type, and is then probably always due as much to forcible torsion of the limb as to vertical strain. The rotation is a very important element in these cases, and the lower end of the upper fragment rides prominently forwards (the ' riding fragment '). The shortening is sometimes less marked than in simple oblique fractures, but th?re is much greater difficulty in getting satisfactory approximation of the fragments, even after freeing the ends of the tibia by operation. This difficulty is probably in most cases due to the broken ends of the fibula be- coming engaged in the fibro-muscular tissues around it, and will necessitate an incision over this bone in order to free them. Treatment. — In the simpler cases reduction is accomplished by flexing and fixing the knee, so as to relax the muscles of the calf, and then making traction on the foot and manipulating the parts into position. The tendo Achillis may, if necessary, be divided. It will usually suffice to put up the limb in a pair of side-splints, such as Cline's, the longer one with the foot-piece being intended PLATE XXII. Fracture of both Bones of the Leg, seen from in front. To ;acc p. 488.] PLATE XXIII. The same Fracture as in Plate XXII., seen from the inner side. From a study of the two skiagrams it will be noticed that both lower fragments have been displaced outwards, with but little alteration in their antero- posterior axes. Tofolltnv Plate XXII. ] INJURIES OF BONES— FRACTURES 489 for the outer side. In other cases it may be better to apply a broad posterior splint with a rectangular foot-piece, e.g., Macintyre's, and two lateral splints ; or the old-fashioned half-box splint may be employed. Some surgeons recommend an anterior wire splint, extending from above the knee to the foot, the leg being subse- quently slung in the flexed position. This maybe advantageously modified by combining it with an additional casing of plaster of Paris. Whatever treatment is adopted, it is necessary to see that the length of the limb is as far as possible maintained, and that no rotation of the lower fragment is present. To ensure absence of rotation, all that is needed is to note that the inner aspect of the great toe, the subcutaneous surface of the internal malleolus, and the inner border of the patella, are in the same line, and correspond with the opposite limb. Union will be sufficiently advanced in two or three weeks at the latest to allow of the limb being put up in plaster, which must be retained for at least another month, and even then a good deal of lameness is likely to persist, which will need subsequent massage. In oblique and spiral fractures there is often very great difficulty in getting the fragments together, and even more in maintaining them in good position. Taking into consideration the degree of permanent depreciation that a man (especially if of the labouring classes) suffers from vicious union of these bones, we have no doubt that the suggestion to cut down on, and wire, screw, or peg the fragments together, is fully justifiable in the hands of skilled surgeons. In the spiral cases the operation may also have to include an incision to free and fix the fibula. Fractures in the neighbourhood of the Ankle-joint are usually produced by indirect violence, the foot slipping, and leading primarily to a displacement of the ankle, the fracture being a secondary result. They would therefore be better described as Fracture-dislocations at the Ankle-joint. 1. Displacement of the Foot outwards is by far the most common variety, constituting what is known as Pott's Fracture. It usually results from the patient slipping on the inside of the foot, as from off a kerbstone. The sudden abduction of the foot results in severe strain upon the internal lateral ligament, which gives way, or the base of the internal malleolus is torn off. The astragalus is thereby driven against the inner aspect of the external malleolus, and tends to displace that portion of bone outwards. The force is thence transferred up the fibula, which bends and breaks at its weakest spot — that is, about 3 inches above the tip of the malleolus — the upper end of the lower fragment being displaced inwards towards the tibia. Where the inferior interosseous tibio- fibular ligament remains intact, the foot itself cannot be displaced upwards, but is merely rotated outwards. The amount of injury inflicted on the tissues of the foot or on the bones of the leg warrants us in describing at least four dis- 490 A MANUAL OF SURGERY tinct lesions to which the term Pott's fracture may be more or less accurately applied, (a) In the first degree, the fibula is broken, and on the inner side merely the internal lateral ligament is torn through (Fig. 164) ; the intact malleolus can then be felt projecting beneath the skin. (b) In the second degree, the malleolus itself is torn off, and a distinct sulcus can be felt be- tween it and the lower end of the tibial shaft (Fig. 165). (c) The third degree is a much more serious lesion. The interosseous tibio fibular ligament yields more or less completely, or the flake of bone to which it is attached is torn off; the foot, carrying with Fig. 164. — Ordinary Pott's Fracture with Rupture of internal Lateral Ligament. Fig. 165. — Pott's Fracture with Internal Malleolus torn OFF. it the lower portion of the fibula and the superficial flake of the tibia, which has been detached, is displaced firstly outwards, and so long as the upper surface does not clear the lower articular surface of the tibia, there is merely lateral displacement with marked abduction of the foot and increased breadth of the ankle (Plate XXIV.). Should the force continue to act, the astragalus may be carried sufficiently outwards to clear the lower end of the tibia, and then an upward and to a less degree a backward displace- ment is added, causing great eversion of the foot and deformity of the ankle. This latter type is sometimes known as Dupiiytren s Fracture . On the inner side either the ligament or the .malleolus PLATE XX. ' Dupuytren's Fracture, with well-marked Displacement outwards of the Foot, as well as of the Lower Fragment of the Fibula and the Internal Malleolus. (Skiagram taken from in front.) To face p. 490. ) ' INJURIES OF BONES—FRACTURES 491 may yield (Fig. 166). (d) The fourth degree consists in the usual type of fracture of the fibula, associated with an almost transverse fracture of the tibia, just above the base of the inner malleolus (Fig. 167). In this variety, the lower end of the shaft of the tibia projects beneath the skin, and is likely to be mistaken for the tip of the malleolus ; if this error is committed, and the fracture allowed to unite without proper rectification, considerable deformity results. In rare instances, the lower end of the tibia may project through the skin, thus rendering the fracture com- pound. In almost all of these varieties the ankle joint itself is opened, Fig. 166. — Dupuvtren's Fracture. Fig. 167.— Fracture of Lower End of Fibula and Tibia simulating Pott's Fracture and this, combined with the amount of .bleeding that occurs into tendon sheaths and muscles around, and the difficulties often associated with fixation of the fragments, explains why the results of these cases are frequently so unsatisfactory. Should union occur with the foot in a false (i.e., everted) position, a large mass of callus develops between the shaft of the tibia and the malleolus. 2. Displacement of the Foot inwards. — When the patient slips on the outer aspect of the foot, the astragalus is forcibly driven against the inner malleolus, which may be broken off or impacted into it. The outer malleolus is dragged inwards with the foot, and owing to the integrity of the inferior tibio-fibular ligament, 492 A MANUAL OF SURGERY which acts as a fulcrum, the fibula yields at the same spot as in Pott's fracture. The foot is displaced inwards, and perhaps slightly backwards. 3. Displacement of the Foot backwards, by catching the heel and tripping forwards, is usually associated with fractures of the tibia and fibula in the same position as in Pott's fracture, but eversion of the foot is absent (see dislocation of the ankle backwards, p. 569). Treatment. — In reducing these fractures, traction should be made upon the foot after the tension of the calf muscles has been relieved by flexing the knee, or by tenotomy of the tendo Achillis ; the position of the internal malleolus must be accurately defined. Before applying the splints, careful attention must be given to the following points : (a) The foot must be maintained at right angles to the leg ; (b) the heel must not project unduly backwards ; and (c) the foot must not be rotated on the leg — i.e., the inner surfaces of the great toe, internal malleolus, and patella must be in the same line. A pair of Cline's splints is generally sufficient to steady the parts. Some cases are better treated, however, by a Dupuytren's splint (Fig. 168), which is really a Liston's splint on a small scale. It reaches from the knee to below the sole of the foot, and is placed on the inner side of the limb, the patient lying on the sound side during its application. A firm pad extends down as far as the base of the internal malleolus, and over this as a fulcrum the foot is drawn inwards by a handkerchief applied around the ankle, and tied to the notches at the end of the splint. The foot being thus fixed, the upper end of the splint is bandaged Fig. 168. — Dupuytren's Splint applied for Pott's Fracture. (Tillmanns.) to the limb. Any tendency to backward displacement of the heel may be counteracted by the use of a Macintyre's back-splint, or by the application of a Syme's anterior horseshoe splint, which can be used in combination with a Dupuytren. It consists of a flat piece of wood, well padded, extending from the knee to the ankle along the crest of the tibia ; the lower end is shaped like a horseshoe, the two limbs passing one on either side of the foot. A handkerchief or piece of bandage is applied, with its centre over the point of the heel ; it passes up on either side between the splint and the foot, winds over the former structure, and is tied INJURIES OF BONES— FRACTURES 493 behind the heel, which is thus lifted forwards. As soon as possible, the limb should be put up in water-glass or plaster of Paris. In the simpler forms, early massage may be employed, and then all the retentive apparatus necessary is some adhesive plaster applied so as to cover in and encase the foot and ankle. In the more difficult cases, where there is considerable displacement and much difficulty in keeping the fragments together, operation to fix them is quite justifiable. In cases of vicious union after Pott's fracture, it is usually necessary to re-divide the fibula, and to excise a V-shnped portion of bone from the tibia extending into the ankle joint, so as to enable the malleolus to be brought in contact with the shaft. Fracture of the Os Calcis may result trom direct violence, such as a blow or fall on the heel, or possibly from muscular action, the epiphysis being then separated, or the shell of bone into which the tendo Achillis is inserted being torn off. The fragment thus separated is displaced upwards by the contraction of the calf muscles, and the resulting deformity is very evident. If the line of fracture passes through the body of the bone there may be no displacement, owing to the attachment of the interosseous and lateral ligaments ; but should the sustentaculum tali be broken, the arch of the foot may be more or less flattened. When due to a fall from a height, the bone is often comminuted and the foot much bruised and swollen. Treatment consists in immobilizing the foot in a plaster case if there is no displacement ; but where the posterior part of the bone is drawn upwards, it must be approxi- mated to the rest of the bone after flexing the leg, in order to relax the calf muscles, or possibly after tenotomy. A more satisfactory result may, however, be obtained by cutting down, and wiring or pegging. Fracture of the Astragalus is usually due to falls on the foot from a height, or from direct violence applied to the foot, as by a weight falling upon it. The lesion is often a severe comminuted one, and portions of the bone may be displaced forwards or back- wards, making a marked projection beneath the skin. In a case recently under our care at hospital, the patient had fallen down a lift, alighting on his feet ; both astragali were smashed, and this probably saved his life. Such accidents are often associated with lesions of the tibia or fibula, and possibly even of the femur. The whole region of the ankle becomes infiltrated with blood, • and an exact diagnosis is sometimes difficult. Treatment consists either in immobilization, which is likely to be followed by stiffness of the ankle, or in bad cases by excision of the bone or of projecting fragments. Occasionally in less severe accidents the bone merely splits across, the lesion being usually situated about the neck. Such is 494 A MANUAL OF SURGERY due either to the weight of the body flattening out the arch of the bone beyond the limits of elasticity, or if the foot is dorsi-flexed to penetration of the bone by the anterior edge of the tibia, im- paction being even produced in this way. Massage and early mobilization should be employed in such cases. Other bones of the tarsus are occasionally fractured, but these lesions require no detailed description. CHAPTER XVIII. DISEASES OF BONE. Inflammation of Bone. In order to assist our readers to correctly understand the subject of inflammation in bone, we must call to mind a few facts relative to its constitution and growth. Bones are divided into the long, the short, and the flat, each of these consisting of compact and cancellous tissue in varying amounts. In the short bones there is but a thin layer of compact tissue surrounding a cancellous central mass, the meshes of which are filled with medullary fat and connective tissue. In the flat bones the compact tissue forms two limiting plates, separated by a layer of cancellous tissue of varying thickness (known in the skull as the diploe). In long bones the shaft consists of a peri- pheral tube of compact structure, surrounding a space which is normally hlled with medulla, and known as the medullary canal ; at each end it gradually merges into a larger mass of loose cancellous tissue, the interstices of which are similarly packed with vascular fatty medulla, which apparently performs the function not only of maintaining the nutrition of the bone, but also of elaborating the blood. Prolongations from the medulla, moreover, extend into the Haversian canals, and are thence con- tinuous with the periosteum, so that the mineral skeleton has incorporated within it a vascular fibro-cellular mass which permeates its whole structure. It must be clearly remembered that there is normally no open hollow space, and therefore no endosteum or internal lining membrane (except in bones con- taining cavities, such as the mastoid cells or frontal sinuses). The vascular supply of a bone is derived (a) from the nutrient artery which passes into the medullary space, and there breaks up into branches which ramify through the whole of the medullary tissue, and thence extend into the Haversian canals ; and (b) from the periosteum, air exceedingly vascular ensheathing membrane, from which small vessels pass perpendicularly into the Haversian canals, and thus establish a communication between the two 49 6 A MANUAL OF SURGERY systems. These latter vessels are especially numerous and large close to the epiphyses. Large veins occur in the medullary and cancellous interior, and are frequently thrombosed in in- flammatory mischief; if the thrombus becomes infected, and so disintegrated, pyaemia is very likely to ensue. The growth of bone manifests itself in three different ways : (i.) It increases in length from the shaft side of the epiphyseal cartilage, the epiphysis itself growing but little. In the upper limb the chief increase in length occurs at the shoulder and wrist, whilst in the leg it is mainly evident on either side of the knee-joint, and this in spite of the fact that the so-called nutrient arteries are directed away from these points ; this would tend to indicate that the importance of these vessels in supplying nutrition to the bones has been much over-rated, (ii.) Increase in breadth is produced by new formation of bone from the deeper layer of the periosteum, which contains many yellow elastic fibres, and a large number of angular nucleated cells, or osteoblasts, which are presumably the bone-forming agents, (iii.) A bone increases in density by a new deposit of osseous tissue around the Haversian canals and cancel- lous spaces. In considering the inflammatory affections of bones, it must always be kept in mind that the essential pathological phenomena (viz., hyperemia, exudation, and tissue changes, active or passive) are similar to those manifested in any other vascular structure, but that the resulting effects are modified by the limited space in which the vessels lie, and the resisting character of the surround- ing osseous tissue. Hence any acute inflammation, resulting in rapid vascular engorgement and considerable exudation quickly poured out, leads to necrosis from thrombosis, due to increased pressure within the unyielding bony canals. If, however, the process is subacute, so that the tissue-liquefying properties of the exudation and the tissue-absorbing activity of the leucocytes can come into play, then osteoporosis or rarefaction of the bone results, a condition sometimes termed caries. On the other hand, if the inflammation is chronic, and due to causes other than tubercle or the pressure of tumours, then new formation occurs, and osteo- sclerosis, or condensation, is most likely to result. Tubercle in bones, as elsewhere, causes primarily rarefaction of the tissue attacked, though sclerosis may be associated with or follow it, and the chronic pressure of tumours or aneurisms leads to rarefac- tion and atrophy locally, although a certain amount of sclerosis may be induced around. One more general fact must be noted, viz., that it is very rare for any inflammatory process to affect solely one element of a bone. The continuity of the vascular supply explains why a periostitis is usually or almost invariably associated with inflam- mation of the subjacent bone, and why an osteomyelitis is never limited to the medullary cavity. DISEASES OF BONE 497 Terminology. — Many different terms have been applied to these pathological processes, and much needless confusion introduced thereby into a subject at all times somewhat complicated. Especially is this the case in inflammatory affections of cancellous or compact bone, the terms ' osteitis ' and ' osteomyelitis ' being used with very little precision. All inflammation of bone occurs in connection with the vascular tissue permeating its structure, and hence, as this is everywhere connected with the medulla, all such processes might be described as forms of osteomyelitis. This term is, however, limited to the affections of the medulla of long bones, whilst the term ' osteitis ' is applied to those occurring in the compact tissue of the shaft of long bones, or in the cancellous tissue at the ends of long bones, or in the interior of short bones, and with such limitations we shall comply here. Then, moreover, the results of disease have been often confounded with the pathological processes leading to them, and the clinical conditions — caries, necrosis, and sclerosis — are described as distinct diseases ; we shall endeavour to avoid this source of error by pre- facing our description of the diseases with a few remarks on each of these clinical conditions. Necrosis, or death of bone, may occur in a variety of forms, and from many different causes, e.g. : (a) From acute localized suppurative periostitis, the sequestrum, or dead mass, being then simply a superficial plate or flake of the compact exterior (Fig. 169); (b) from acute idiopathic infective osteomyelitis (acute panostitis or acute necrosis), the sequestrum then often involving the whole thickness of the bone, and invading more or less of the length of the diaphysis, if the condition is not early and efficiently treated (Figs. 171 and 172) ; (c) from acute septic osteomyelitis, usually traumatic in origin, the sequestrum being annular in shape, and involving more of the interior of the bone than of the exterior (Fig. 173 ) ; (d) from acute or subacute septic osteitis of cancellous bone, the sequestra being small spicu- lated fragments of the bony cancelli which have, escaped absorption by the granulation tissue always forming in such a process ; (e) from tuberculous disease of cancellous tissue, the sequestrum being light and porous, often infiltrated with curdy material, and rarely separated completely from surrounding parts ; (/) from syphilitic disease of cancellous or compact tissue, usually resulting from excessive sclerosis, or gummatous disease of the periosteum which has become septic ; (g) from the action of local irritants, e.g., mercury, or phosphorus fumes gaining access to the interior of the teeth ; (h) occasionally as a simple senile loss of nutrition, as in senile gangrene ; and (i) a variety, described by Sir James Paget under the name of ' quiet necrosis,' occurs as a result of direct injury, the sequestrum separating without suppuration ; it is one of the causes of loose bodies in joints, and especially the knee, following a blow en one of the condyles. 32 498 A MANUAL OF SURGERY The separation of sequestra is always brought about by a process analogous to that by means of which sloughs and gangrenous materials are cast off from the body, viz., by complete absorp- tion if small, aseptic, and surrounded by sufficiently vascular tissue ; by absorption of as much as possible, in larger aseptic masses, granulation tissue invading and replacing the dead mass, and a line of separation forming as a result of defective nutrition of the most advanced layer ; or, if septic, an active rarefying inflammation occurs in the neighbouring living tissue, which in time breaks down, and so sets free the dead mass. (See in more detail at p. 69.) From the eroding action of the granulation tissue, the under surface of the sequestrum is always hollowed out, and, as it were, worm-eaten in appearance. Where sepsis is present, the process is more active, and is completed more rapidly, though with greater risk to the patient. Caries, or, as it is sometimes called, osteoporosis, or rarefaction of bone, is a clinical condition resulting from inflammation, and con- sisting in a soft and spongy state of the bone, which, if it can be reached, readily breaks down on pressure with a probe. It may result from the following conditions : (a) A simple subacute in- flammatory process, e.g., during the early stage of repair in a fracture ; (b) from acute or subacute septic or infective inflamma- tion of cancellous tissue ; (c) from tuberculous affections of the cancellous tissue or periosteum ; (d) from syphilitic disease of the medulla or of the under surface of the periosteum. Pathologically, it is characterized by the replacement of the medulla by granulation tissue, which usually contains some large multi-nucleated cells, or osteoclasts, and these seem to be closely connected with the removal of the bone, though we are at present in ignorance of the manner in which this is effected. The cancellous tissue becomes hollowed out to accommodate these granulations, and the osteoclasts are usually found occupying shallow depres- sions known as ' Howship's lacunae.' In tuberculous and syphilitic lesions the bone corpuscles undergo fatty degeneration. Certain terms are used to indicate the characteristics observed in particular cases. By Caries sicca is meant that the process occurs without suppuration ; in C. suppurativa pus is always present ; in C. fungosa the granulation tissue is exceedingly abun- dant, especially in tuberculous disease of the articular ends of bones ; in C. necrotica necrosis is associated with caries, the sequestra consisting either of spiculated fragments, or in tuber- culous disease of larger masses. If caries is recovered from, a subsequent condition of sclerosis usually follows, with loss of substance and often deformity. Sclerosis of bone (osteosclerosis) is invariably the result of some chronic inflammatory affection, e.g., (a) chronic periostitis, whether simple or syphilitic ; (b) chronic osteomyelitis, simple, tuber- culous, or syphilitic ; or (c) chronic osteitis of the compact bone, DISEASES OF BONE 49g which is always secondary to one of the former. In all cases the condition is due to a slow formation of new bone within the Haversian canals or cancellous spaces, thus diminishing their lumen ; in syphilis this may progress to such an extent as to lead to their total occlusion, and even to localized necrosis from lack of blood-supply, especially when sepsis has occurred. In tuberculous bones the sclerosed tissue is always at some distance from the focus of mischief, and may be looked on as Nature's attempt to limit the spread of the disease ; it forms also the final tissue or bone-scar in the process of repair in those cases where a cure has been obtained by natural or surgical means. Classification of Inflammatory Affections of Bone. I . Periostitis : (a) Acute localized, with or without suppuration. (b) Acute diffuse, always associated with or secondary to acute infective osteomyelitis. (c) Chronic simple, or hyperplastic. (d) Chronic tuberculous. (V) Chronic syphilitic. II. Osteitis, or inflammation of compact bone, which is always associated with and secondary to either periostitis or osteomyelitis, and so will not be described separately. The acute form results in necrosis, the subacute in osteoporosis, and the chronic in sclerosis, except in tuberculous disease. III. Osteomyelitis, or inflammation of the medulla of long bones : (a) Acute septic (traumatic). (b) Acute infective (idiopathic = acute panostitis). (c) Subacute simple or infective, e.g., after fractures, or during the separation of sequestra, resulting primarily in rarefaction, but finally in sclerosis. (d) Chronic simple, tuberculous or syphilitic, usually causing general enlargement and sclerosis of the bone, even if locally some rarefaction is present. IV. Inflammation of the Cancellous Tissue (Osteitis) may similarly be : (a) Acute septic or traumatic. (b) Acute infective. (c) Subacute simple or septic. (d) Chronic simple, syphilitic, or tuberculous. When limited to the articular end of a bone in a young person, this is sometimes termed Epiphysitis. It is unnecessary to describe in detail all these conditions, since many of the divisions overlap, and hence we shall group together 5°o A MANUAL OF SURGERY the various acute and chronic affections in order to indicate the clinical signs and symptoms. Acute Inflammations of Bone. i. Acute Localized Periostitis usually arises as a result of traumatism applied directly to the bone, with or without an open wound ; it may also be determined by general conditions, such as rheumatism, gout, and pyaemia, or by an extension of inflam- matory mischief, as in an alveolar abscess. Pathologically, the process consists of hyperemia of and exuda- tion into the periosteum, which becomes swollen, turgid, and thickened. This may be followed in due course by resolution, or may leave the bone thickened and in a condition of chronic inflam- mation ; or suppuration may ensue, and with it usually a limited ffi Fig. 169. — Superficial Necrosis resulting from a Localized Periostitis (Diagrammatic). A represents the necrosed tissue lying in continuity with the surrounding living bone ; the periosteum is stripped up from it, and has an opening through which the pus has been discharged. B shows a later stage, in which the sequestrum is being separated by a process of rarefying osteitis in the immediately contiguous living bone, whilst an involucrum, or sheath of new bone, is formed from the under surface of the periosteum ; a cloacal aperture remains in the involucrum for the escape of discharges. C shows the condition of affairs after the sequestrum has been removed. superficial necrosis. In the last event pyogenic organisms of no great virulence must find an entrance to the area of mischief, and probably in cases due to trauma through the abraded or injured skin ; in other instances they may come from neighbouring foci of inflammation, or possibly auto-infection may occur. The in- flammatory process extends to the small vessels entering the bone from the under surface of the periosteum ; these become dilated, next thrombosed and strangled by the pressure of the exudation DISEASES OF BONE 501 around them, and finally pulled out from the osseous canals by the tension of the subperiosteal effusion and by the peptonizing power of the bacterial products. Consequently, the vitality of the superficial layer of bone is destroyed for an area corresponding almost exactly to that from which the periosteum has been stripped (Fig. 169, A). As soon as tension has been relieved by the escape of the pus, repair commences. Where the mischief is very slight and super- ficial, the involved bone may entirely recover, or even small necrotic portions be absorbed. If the dead portion of bone is more extensive, it will be separated from the subjacent living tissues by one of the processes already described (p. 498), whilst from the under surface of the stripped-up periosteum a casing of new bone is developed, constituting an involucrum or sheath, at first spongy and cancellous in texture, but finally hard and sclerosed. In the centre of this new formation are found one or more openings or cloaca through which the discharge passes, and corresponding in position to the openings in the periosteum and skin made by Nature or the knife (Fig. 169, B). Clinically, the symptoms of acute localized periostitis consist in the ordinary phenomena of acute inflammation, the pain being of an intense aching character, worse at night, and increased by lowering the limb or by any kind of pressure. If a subcutaneous portion of bone is involved, a painful swelling develops, at first brawny in character, but, when suppuration has occurred, the centre softens, whilst the skin over it becomes red and cedematous. When an abscess has burst or been opened, bare bone is felt beneath the periosteum, and the greater part of this denuded structure usually dies, and must then be either absorbed or separated ; in either case a sinus remains for a time, leading down through a cloaca in the involucrum to the sequestral cavity. From this either pus or serum will be discharged, according to whether the wound has become septic or not. In about five or six weeks' time the sequestrum is loose, and this may be ascer- tained by moving it with a probe within the osseous cavity, which is now lined on the inner aspect with granulation tissue. Treatment. — Rest, elevation of the limb, leeches, and fomenta- tions are usually relied on locally in the early stages, whilst a good purge and specific anti-diathetic remedies may be used generally. If, however, the affection is not readily checked, and suppuration threatens, a free aseptic incision down to the bone is the best means of preventing necrosis. Should an abscess form, it must be opened early, and possibly by this means death of the bone may be obviated or limited. When necrosis has occurred, the parts must be carefully dressed and kept aseptic, until the sequestrum is detached. An incision is then made over the involucrum, the periosteum stripped from it, one of the cloacae enlarged, and the dead bone removed. The cavity will now rapidly 502 A MANUAL OF SURGERY fill up with granulations, and heal completely. In many cases recovery may be expedited by chiselling away those portions of dead bone which must ultimately be separated without waiting for the tardy process of Nature ; this should not be undertaken until the destructive changes have ceased, and then only to a limited extent. The dead bone is recognised from the living by its white appearance and by not bleeding when cut. 2. Acute Infective Osteomyelitis (Syn. : Acute Necrosis, Acute Diffuse or Infective Periostitis, Acute Diaphysitis, Acute Panostitis). — This disease usually occurs in children, often of a tuberculous inheritance, and not unfrequently follows one of the exanthemata (e.g., measles or scarlet fever). It generally commences before the age of puberty, and is an affection of the gravest import ; the multiplicity of names attached to it suggest quite accurately that its manifestations may be very diverse in character. Pathology. — The patients are always in a state of depressed general health, so that their germicidal powers are considerably diminished. Moreover, spots of localized ulceration are often present in the throat, mouth, or intestines, which give a ready entrance for micro-organisms into the system. Evidently some of these must be circulating within the blood, ready to attack any area of diminished tissue resistance. A slight injury in the shape of a strain or a wrench, which is often entirely overlooked or for- gotten, may suffice to determine the commencement of an in- flammatory process which rapidly spreads by continuity of tissue, until perhaps the whole structure of the bone may be affected. The majority of the ligaments and not a few tendons are inserted into the epiphysis, and it is not difficult to appreciate the fact that articular strain must be mainly felt in the juxta- epiphyseal region, i.e., immediately beyond these insertions. It has been already mentioned that the traumatic separation of epiphyses is liable to be followed by suppuration, even in healthy children, and it is easy to understand that in an unhealthy child a very slight injury in the epiphyseal region may determine a similar process. The disease almost always starts in the soft vascular tissue on the shaft side of the epiphyseal cartilage, but occasionally it com- mences in the epiphysis itself at the margin of the ossifying centre, and in a few instances (mainly amongst young adults) it may be preceded by a patch of localized periostitis, suggesting that an acute infection ha^ supervened upon a subacute periosteal focus. The bacteria, once admitted, grow and multiply rapidly, and give rise to inflammatory phenomena, the nature and extent of which depend largely on the exact situation of the infective focus, the amount of resistance offered by surrounding tissues, and the virulence of the organisms. As in any other part of the body, the trouble is most likely to travel along the line of least resistance, i. If the process commences in the periphery of the juxta- DISEASES OF BONE So.? epiphyseal region close to the periosteum, the line of least resist- ance will be towards that structure, and hence a sub -periosteal abscess may form, whilst the central portions of the bone may escape almost entirely. The extent of this abscess depends mainly upon the virulence of the bacteria, but considerable portions of the diaphysismaybe denuded, resulting in extensive necrosis, which, however, involves the superficial rather than the deeper parts. It rarely extends to the neighbouring joint owing to the close bond of union which exists between the diaphyseal periosteum and the epiphyseal cartilage. In this variety an early incision to let out the pus may suffice to prevent necrosis, or, at any rate, to limit it. The constitu- tional symptoms will be less severe than in other varieties ; there is less likelihood of the development of pyaemia, and the toxic fever soon dis- appears after the removal of the pus. Subsequently the same course of events occurs as in the localized variety of acute periostitis — viz., an involucrum forms, perforated by one or more cloacae, and the sequestrum in time separates. FlG - 170. —Acute Osteo- A good illustration of this type is pyelitis of the Lower , & , . . ;1 ■ .-,- End of the Femur in a to be found in the acute periostitis Child of Nine Weeks. which affects the lower end of the femur. (After Lexer.) It almost always starts posteriorly, IC internal condyle ; K, centre stripping the thin periosteum off the of ossification in epiphysis; back of the bone as far as the bifurca- A, abscess cavity in epiphyseal tion of the linea aspera. Its prefer- lin f ; S ' sequestrum; I, in- r . . . . r . . , , f j volucrum. ence tor this situation is evidently due to the fact that strains upon the knee-joint are mainly experienced when the limb is hyper-extended, and that such strain is directed to the posterior ligaments, and hence the posterior portion of the epiphyseal line is likely to suffer. An abscess forms, and inasmuch as it lies deeply and its origin is not easily recognised, it is allowed to progress for some time, one result being that the osteogenetic powers of the periosteum are destroyed, so that an involucrum rarely forms in this particular example of necrosis. Removal of the sequestrum is also difficult from anatomical reasons, and hence amputation is sometimes required. 2. Should the process start in the centre of the juxta-epiphyseal 504 A MANUAL OF SURGERY region, it may spread in several directions, and the results vary considerably. (a) The process may reach the periosteum first and then the phenomena of a diffuse sub-periosteal abscess, as indicated above, with the addition of the symptoms due to its deeper origin, will manifest themselves. This is, perhaps, the most usual course for the disease to take. (b) Less frequently the infection extends along the medullary cavity and gives rise to the most typical form of osteomyelitis (Fig. 170). The medulla becomes intensely hypersemic ; the veins are thrombosed ; localized foci of suppuration and gangrene appear ; and in consequence of the increased pressure infective emboli are likely to be detached and pyaemia to follow. Even if the latter does not occur, the general condition is profoundly affected by the absorption of toxins. Suppuration also occurs beneath the periosteum, although the amount of pus may not be great at first; but the membrane is stripped up from the diaphysis, perhaps to such an extent as to involve the whole length and circumference of the shaft. Unless prompt measures are taken to limit the progress of the disease, necrosis is certain to follow, usually implicating the whole thickness of the diaphysis, and sometimes extending along its whole length. In fact, the whole diaphysis is occasionally found lying loose in an abscess cavity, the two epiphyses having been previously separated. (c) It has been already mentioned that, owing to the intimate connection between the periosteum of the diaphysis and the epiphyseal cartilage, the neighbouring joint usually escapes infec- tion. Should, however, the epiphyseal line be within the joint, as in the hip, it must perforce become the seat of an acute infective arthritis as soon as the bacteria reach its periphery. The elbow- joint is similarly liable to suffer when bacteria attack the upper end of the ulna, since the epiphysis is a mere flake of bone and the greater part of the olecranon is derived from the shaft. Sometimes the junction cartilage is softened and destroyed by the organisms, so that the inflammation spreads through the epiphysis to the articular cartilage, which is eroded, and the joint opened. Occa- sionally the pus burrows along the soft tissues outside the bone, as along the biceps groove into the shoulder-joint. In infants, where there is little or no bone, the cartilage may be rapidly destroyed, and an opening made through it into the joint, giving rise to what was described by Sir Thomas Smith as the acute arthritis of infants. ( A MANUAL OF SURGERY the bones or also involves the joints. In the early stages one part of the foot may he more swollen than another, according to the location of the trouble. The os calcis is most often affected, and afterwards, in order of frequency, come the first metatarsal, astragalus (the head), and scaphoid. When it starts in the astragalus, the swelling occurs below the level of the ankle-joint in front of or behind the malleoli, whilst pressure over the head of the bone gives rise to pain. The foot is usually in a position of equinus, but not to such a marked degree as when the ankle- joint itself is affected ; the subastragaloid movements (inversion and eversion, abduction and adduction) are also considerably limited, or may' be absent. An examination of the accompanying illustration (Fig 176) will explain the fact that tuberculous disease Fig. 176. — Arrangement of Synovial Membranes of Foot. 1, Posterior calcaneo-astragaloid, behind the interosseous ligament ; 2, anterior calcaneo-astragaloid and astragalo-scaphoid ; 3, calcaneo-cuboid ; 4, cubo- metatarsal ; 5, the large common sac between scaphoid and cuneiform, between the cuneiform, and between the cuneiform and second and third metatarsals ; 6, between the internal cuneiform and first metatarsal starting in the astragalus is very likely to involve the ankle-joint, or to spread to the os calcis or scaphoid. Disease of the os calcis leads to more limited swelling of the back of the foot on one or both sides of the heel ; the movements of the ankle will not be impaired, although walking is painful, and hence the patient limps, treading only on the toes. Further forwards tuberculous disease is most likely to start in or around the scaphoid, the bulbous swelling of the foot being then shifted anteriorly, and the movements of the ankle remaining unimpaired. The prognosis is much worse when the disease attacks the inner half of the foot, comprising the astragalus, scaphoid, cuneiform, and three inner metatarsal bones, owing to the arrangement of the synovial membranes, than when it affects the outer segment consisting of the cuboid and two outer metatarsals, which are excluded from DISEASES OF BONE 5'7 the general synovial membrane, and are thus more amenable to treatment. Sooner or later suppuration occurs with increased pain, and, should the sinus which results from opening the abscess become septic, the trouble is sure to spread much more rapidly, and the prognosis becomes increasingly grave. Treatment is conducted according to the rules which always guide us in that of tuberculous disease. In the early stages the foot and ankle arc immobilized, and preferably in plaster of Paris or water-glass. The child is sent to the seaside, and plenty of good food administered, and it is not allowed to walk until all pain has ceased; even then the plasler case must be retained until Fig. 177. -Chronic Abscess in the Lower End of the Tibia. (Kings' College Museum.) the swelling has entirely disappeared. It is wise to remove the plaster every month or two for inspection and readjustment. Should the disease persist in spite of such treatment, or should suppuration occur, removal of the tuberculous tissue by operation may be required. If the os calcis alone is involved, it will usually suffice to open well into it either from one or both sides, to scrape out its interior and then pack it with iodoform and gauze after disinfecting it with liquefied carbolic acid. Decalcified bone chips mixed with iodoform have been packed into the cavity in order to hasten bony consolidation, but not with much success ; in any case the interior of the bone becomes occupied by fibrous tissue, with perhaps a few bony spicules, and a marked permanent 5«8 A MANUAL OF SURGERY depression always remains at the site of operation. Excision of the os calcis was formerly practised, but is not to be recommended, since even if performed subperiosteally, the power of repair that remains is very slight. If the disease mainly affects the astragalus, it may suffice to remove it entirely, neighbouring articulations being curetted, if need be ; but probably the disease will have spread so far that amputation will be required, and then Syme's operation is better than methods such as Pirogoff's, which retain any portion of the tarsus. Disease of the cuboid and outer half of the foot in front of the os calcis can often be dealt with B ^f7 p£$fcu ^ Fig. 178. — Lower End of Tibia affected with Tuberculous Disease. (From King's College Museum.) In A, a subperiosteal deposit of new bone is seen surrounding an opening (cl), which leads into the interior of the bone ; in B, the interior of the same bone is seen, and shows a sequestrum (S) just above the epiphyseal line. The ankle joint is healthy. efficiently by scraping, but when the common synovial membrane on the inner side is involved, amputation will probably be required, failing success by conservative measures. (c) If the tuberculous disease affects the ends of long bones, it most commonly starts in the epiphysis, or under the articular cartilage, though sometimes on the shaft side of the epiphyseal cartilage. The changes already described take place, and lead to early destruction of the latter cartilage, so that the adjacent parts of both epiphysis and diaphysis become involved (tuberculous DISEASES OF BONE 5'9 epiphysitis). The general signs are similar to those present when the smaller bones are affected, but the results produced may vary considerably, (i.) In the slighter forms, where efficient treatment is adopted, the tuberculous tissue may be totally ab- sorbed, and the process thus comes to an end, though the affec- tion of the epiphyseal cartilage may lead to subsequent impair- ment of growth, (ii.) In others it may be circumscribeel by the bone becoming sclerosed around a caseating focus, and then, if suppuration ensues, a deep abscess in the cud of the bone may be produced (Fig. 177). Such is rarely of large size, containing at most 1 or 2 drachms of curdy pus, and is lined by a definite pyogenic membrane of the usual tuberculous type. - - ~^' . % The effects produced by this condition are similar to those of chronic osteo- * '& periostitis, viz., a deep aching or boring pain in the bone, worse at night, together with enlargement of the affected part, whilst one spot is often very tender on palpation. If it has existed for any length, of time, the whole shaft may become enlarged as a result of chronic osteo-peri- ostitis (p. 511). (iii.) The disease may burrow along the epiphyseal line, and find its way into the neigh- bouring joint, if the epi- physis is intra -articular, as in the hip ; but if the epiphyseal cartilage is placed beyond the limits of the capsule, a subperiosteal extra-articular abscess will result (Fig. 178). Should the disease spread equally in all directions, the epiphysis may actually be separated, (iv.) A more common result is for the whole or part of the cancellous tissue of the epiphysis to become involved, and the joint to be secondarily affected with tuberculous arthritis, either by perfora- tion, erosion, or necrosis of the articular cartilage, or by extension to the synovial membrane around its margins, (v.) The process may sometimes extend upwards along the medulla into the shaft, causing a diffuse osteo-periostitis with or without a medullary abscess (Fig. 179). Fig. 179. — Localized Abscess in the Lower End of the Femur, extending from the Epiphyseal Line upwards into the Medulla. (From Specimen in the College of Surgeons' Museum.) 520 A MANUAL OF SURGERY The Treatment of tuberculous epiphysitis is conducted in the first place by absolute immobilization and hygienic measures ; but the surgeon must not be tempted to trust too long to such a regime, for fear of the joint becoming also affected. As soon as possible, an opening should be made into the interior of the epiphysis, and all the pulpy granulation tissue, caseous debris, or diseased bone removed with a sharp spoon, the cavity being sub- sequently disinfected, and stuffed with gauze infiltrated with iodoform. Of course, the utmost care must be taken not to open the joint by scraping through the articular cartilage. Where a chronic abscess exists in the end of a bone, a trephine should be applied over the tender spot, and, if the cavity is not at first opened, the bone may be drilled in different directions to ascertain whether or not pus exists. (d) The medullary canal of the shaft of a long bone sometimes becomes the seat of tuberculous disease ; this, as also the abscess of bone described above, is more common in adults than in children. The part thus affected becomes carious, with or with- out the formation of sequestra or pus; but the most marked feature of this deep-seated central trouble is that the whole bone passes into a state of chronic inflammation, which we have described, as well as the treatment necessary for it, under the title of chronic diffuse osteo-periostitis (p. 511). Syphilitic Diseases of Bone. The osseous tissues may be involved in acquired syphilis in either the secondary or the tertiary periods. In the Secondary Stage flying pains about the bones (sometimes termed osteocopic) are often complained of ; they are, however, of but little importance, and disappear rapidly as the patient gets under the influence of mercury. In the late secondary or early tertiary periods, a periosteal node is often met with, as a result of chronic periostitis. It usually affects only one bone, and most commonly the tibia, and consists of an infiltration and thickening of the periosteum, which may entirely disappear, but later on is accompanied by a formation of new bone. This is at first spongy and soft in character, but after a while becomes hard and sclerosed ; the Haversian canals are always placed at right angles to the subjacent osseous tissues. When such has once occurred, absorption of the newly formed bone does not readily follow, even under treatment, the part perhaps remaining permanently thickened. It is recognised clinically as a fusiform swelling, a little tender on pressure, and the seat of deep aching pain, usually worse at night. It must be understood that the pain is not so much associated with the onset of night as with the increased warmth of the limbs when in bed ; indeed, patients with syphilitic tibia? frequently sleep with their legs exposed. Night- DISEASES OF BONE 521 watchmen and others, on the contrary, complain of pain during the day, when they take their rest. Suppuration does not often occur, and constitutional rather than local treatment is required. In the Tertiary Period the bones may participate in the changes which involve any and every tissue of the body. These consist in an infiltration and overgrowth of the connective tissues, which if diffused through an organ produce sclerosis, if localized to one spot lead to the formation of a gumma. Hence the following lesions are met with : (a) The formation of subperiosteal gummata, either localized or diffuse, probably resulting in caries of the subjacent bone ; if the affection is limited, only a small portion may be thus involved; but HG. iSo. -Diffuse Gummatous Disease and Caries of the Skull. (From King's College Museum.) where it is widely diffused, an extensive surface of the bone may become eroded and irregular. This process is sometimes accom- panied by a development of new bone under the adjacent peri- osteum, and is very often complicated by sclerosis and necrosis. The calvarium is the part most frequently involved in this change, but, owing to the osteogenetic powers of the pericranium being small, there is rarely any new formation of bone in the neigh- bourhood, and thus the skull may present a curious worm-eaten appearance (Fig. 180). Frequently the gummata break down and destroy the superficial scalp tissues, leaving deep and extensive wounds, discharging an abundance of foul pus, at the bottom of which bare and even dead bone may be felt. 522 A MANUAL OF SURGERY (b) At the same time a condition of sclerosis may be produced in the underlying or surrounding parts, and this may progress to such a degree as to seriously compress and constrict the vessels in the Haversian canals. Moreover, an obliterative endarteritis is almost always present, and these factors, combined with the separation of the periosteum by the above-mentioned gummatous changes, so interfere with the vitality of the bone, that should sepsis occur in the broken-down gummata, necrosis is almost certain to ensue, especially in the skull. The effects produced vary considerably in different cases, and especially with the situation. When the calvarimn is attacked, septic phenomena are com- monly present, and necrosis is a usual accompaniment of the gummatous changes. The process in such a case, as is represented in Fig. 181, would probably be as follows : The pericranium corresponding to the necrotic area became gummatous, and at the same time the subjacent bone underwent sclerosis. Sooner or later the gummata burst or were opened; septic changes supervened, and the scalp tissues were stripped off the calvarium to the limits of the disease, necrosis result- ing in the sclerosed area of bone. A line of rarefaction subsequently formed around the sequestrum in conse- quence of Nature's attempts to separate it. The disease is marked by its extreme chronicity, the sequestrum lying bare in the wound perhaps for years without being separated, owing to the slight degree of vascularity and the extreme condensation of the sur- rounding parts. Moreover, as explained above, there is an entire absence of an involucrum. In the shafts of long bones, where the compact tissue is thick and resistant, there may be extensive periosteal disease, with but little affection of the underlying parts ; but if this compact layer is thin, and especially when the cancellous ends are involved, a considerable amount of destruction from caries may result, though if sepsis is not admitted there will be an entire absence of necrosis. In the Treatment constitutional remedies, in the form of iodide FiG. 181. — Syphilitic Necrosis of the Skull The sequestrum is becoming separated, and a ring of caries is forming around it DISEASES OF BONE 523 of potassium and mercury, should, if possible, be depended on. Gummata should never be opened without the strictest attention to asepsis. If sepsis has occurred, the wounds may be treated by applying iodoform and dressing with lint steeped in lotio nigra, or covered with mercurial ointment. Counter-openings are often required for purposes of drainage, especially in the scalp. Necrosed portions, when separated, are to be removed, carious tissue may be scraped away with a sharp spoon, and the surface powdered with iodoform and dressed antiseptically. In the calvarium no attempt must be made to chisel away the dead bone. (c) Occasionally a gummatous osteomyelitis is met with, in which a gumma forms in the interior of a bone. It results in the so-called expansion of bone and secondary thickening and enlarge- ment of its whole structure, i.e., a diffuse osteo-periostitis. The symptoms are the same as those described for the latter affection, and if it resists the administration of anti-syphilitic remedies, it must be treated in the same way, viz., by separation of the periosteum, freely opening the medullary cavity, and removing all diseased tissue. These cases when affecting the long bones have often been mistaken for malignant growths ; necessarily, it is a matter of the most vital importance to come to a right conclusion as to their nature. The greater rapidity of growth in the syphilitic cases, and the evidences of syphilis elsewhere, or of a syphilitic history, will often guide the surgeon to a right conclusion ; but if there is any doubt an exploratory incision should always be under- taken before amputation is resorted to. In Inherited Syphilis any of the above manifestations may be seen, but with more or less special features added, and, in addition to these, certain forms which do not occur in the acquired type of the disease have been described. 1. A new formation of bone beneath the periosteum is perhaps the most frequent result, and this occurs with but little pain. Perhaps the most common situation of this lesion in infants is the calvarium, where bony masses known as Parrot's nodes form around the anterior fontanelle, causing the top of the skull to resemble a ' hot cross bun ' in shape. In the early stages the bone is soft and spongy, and on post-mortem examination is dark red or maroon in colour. If the process is not checked by suitable anti-syphilitic treatment, the newly-formed osseous tissue becomes dense and sclerosed, and the deformity may then persist through life (Fig. 18, p. 138). Any part of the calvarium may, however, be affected, and the change is not necessarily limited to the first years of life. 2. A similar condition is met with in the shafts of long bones, due to the deposition of alternating lamellae of soft and hard bone, outside the ordinary compact tissue. 3. Syphilitic epiphysitis (or, as it is termed, syphilitic osteo- 524 A MANUAL OF SURGERY ■ hondntis) is a lesion characterized by enlargement of the ends of the bones, met with in infants, and somewhat resembling rickets, but coming on at an earlier date. The enlargement is mainly situated in the epiphysis, but not uncommonly extends some way along the shaft, thus contrasting forcibly with rickets. Occasionally only one side of the epiphysis is affected. The change commences in the zone of calcified cartilage nearest the diaphysis, which becomes friable, opaque, and irregular, and as the condition progresses it may be transformed into granulation tissue, so that separation of the epiphysis follows. This in turn sometimes results in suppuration and acute arthritis, or the limb hangs powerless in a condition known as syphilitic pseudo-paralysis. The disease is usually symmetrical, and often multiple, and situated in much the same positions as rachitic affections, the knees, elbows, and wrists being perhaps most often affected. 4. A symmetrical overgrowth of the tibiae, perhaps combined with an anterior curvature, also occurs in syphilitic children, resulting in permanent elongation of the legs (p. 400). 5. Craniotabes consists of a localised absorption of the osseous tissue of the cranium, leaving small areas where the bone is thinned or absent, so that on pressure a sensation of crackling, like that of parchment, is imparted to the finger. It occurs most frequently in the parietal bone (in 60 per cent, alone ; in 95 per cent, witli other bones — Carpenter'-''), and in the majority of cases within the first six months of life, a fact that throws considerable doubt on the idea that it is due to rickets. The Treatment of syphilitic lesions in children must be earned out in acccordance with general principles, and mainly by the administration of suitable drugs. Rickets. Rickets is a general disease of malnutrition, occurring in children, and manifesting itself mainly in lesions connected with the bones. It usually commences within the first three years of life, but sometimes appears later. Causes. — Any and every fault in the hygienic and dietetic treat- ment of a child seems capable of inducing rickets ; but the most important factor in its aetiology is insufficient or improper food, especially the too early administration of starchy materials, whilst uncleanliness and want of air and light also predispose to it. Prolonged lactation is not necessarily a cause, if the mother is healthy and capable of feeding the child ; but amongst poor patients this habit is frequently responsible for its appearance, although in Japan, where the children are suckled for two or * Carpenter. ' Syphilis of Children in Every-day Practice.' Bailliere, Tindall and Cox. 1901. DISEASES OF BONE 525 three years, the disease is unknown. Rickets is common in the poorer classes, who are herded together in small and badiy ventilated rooms, and is so peculiarly frequent in this country as to be known in Germany as the ' English disease ' (Englischt kvankheit). The Symptoms may be divided into the early or general, and the later or osseous. The general symptoms are mainly referable to a state of irritability of the gastro-intestinal mucous membrane. The child may be fat and flabby, or thin and emaciated ; the mucous membranes are pale, and vomiting and diarrhoea are constantly present, the motions being often green, slimy, and very offensive. The spleen is enlarged, the abdomen tumid, and profuse sweating of the head is very characteristic. The commencement of the osseous changes is usually indicated by increasing irritability and restlessness, the child tossing off his bed-clothes at night, and crying out when handled or touched. The articular ends of the long bones become enlarged, as also the junction of the costal cartilages with the ribs. Sooner or later the shafts of the long bones soften, and may bend in various directions, and thus many deformities may be produced. The head usually becomes flattened antero-posteriorly, so that the forehead appears square in shape and enlarged, whilst frontal bosses may develop on either side, due to new formation of bone under the periosteum ; it is a question, however, whether these are not syphilitic rather than rachitic in origin. The fontanelles remain open much longer than usual, and craniotabes is said to occur. The teeth do not erupt till late, and are stunted, defective in enamel, and easily eroded, so that the ends of the incisors are often concave ; they must not be mistaken for syphilitic teeth, since the concavity is a small arc of a large circle, whilst the typical notch of syphilis is a large segment of a small circle. The spine may be affected by kyphosis (p. 386), or less frequently by scoliosis (p. 381) ; the kyphotic curve results when the patient is allowed to lie too much in bed with the head on a high pillow, or if it is carried about with a curved back ; scoliosis more often occurs when the patient is able to walk. Occasionally the two conditions are associated in the same child, a kypho-scoliosis resulting, which is usually due to its being carried about sitting on a nurse's arm with the pelvis tilted. Changes in the thorax are produced by enlargement of the costo-chondral junctions (beaded ribs), which, when present on either side of the sternum, produce what is known as the rickety rosary. If there is any obstruction to the entrance of air into the lungs, as from a tracheitis or bronchitis, the atmospheric pressure may cause the softened bone and cartilage to sink inwards, and as a result of this the sternum may be pushed forwards {pigeon breast), whilst the curvature of the ribs at the angle is increased. A very characteristic feature of the rickety change consists in the 526 A MANUAL OF SURGERY lateral groove thus produced on each side of the sternum, which may meet with a transverse depression below, caused by the projection of the lower ribs by the tumid abdomen. The pelvis is flattened antero- posterior^, or more rarely tri- radiate, the former condition being produced when the patient lies habitually on his back, the latter only occurring when he is allowed to walk about, the ace- tabula being thus pressed in- wards and backwards by the heads of the femora. The deformity of the long bones (Fig. 182) usually consists in an increase in their natural curves, especially at points where power- ful muscles are attached. The femora are curved antero-pos- teriorly, and the tibiaein a similar direction, although there is often some lateral displacement super added. Genu valgum or varum may also result from the epiphy- seal changes. When the acute stage of rickets has passed away, any deformities present become fixed by the complete ossification of the softened bony tissues. As a rule, the density of such de- formed bones is increased, whilst their natural shape is altered by deposits of new subperiosteal bone or struts in the concavities, so that on section they are usually more or less flattened from side to side. Growth is often checked by this disease, so that the individual becomes stunted and dwarf-like. Pathologically, the chief changes in rickets are found in the neighbourhood of the epiphyses. Ordinarily, the epiphyseal cartilage is a lamella about a line in thickness, bounded on either side by a zone of calcified tissue, containing regular alveolar spaces filled with vascular medulla, and lined by osteoblasts, shelving gradually into normal cancellous bone. In rickets the epiphyseal cartilage is not only circumferentially enlarged, but also Fig. i32. — Pelvis and Leg-bones in Rickets. (From College of Surgeons' Museum.) DISEASES OF BONE 527 thickened and irregular (Fig. 183), outgrowths of cartilage project- ing on either side into the calcified tissue, which is more abundant and more open in texture than usual, whilst it passes irregularly into the cancellous bone. Thus, there is an increase in the material which Nature prepares for the formation of bone, but the ossifying process is inefficiently carried out. In addition to this, the Haversian canal systems and the medullary spaces in the Fig. 184. — Transverse Section through the Shaft of the Ulna from a Rickety Child of Thirteen Months ( x 10), showing Spongy Tissue beneath the Periosteum instead of the Com- pact Tissue of Normal Bone. Fig. 183. — Section through Lower End of Rickety Radius, showing Exagger- ated Depth and Irregular Borders of the Prolifer- ating Epiphyseal Carti- lage. (From Ashby and Wright' c ' Diseases of Children.') diaphyses are enlarged, so that the bones become weaker and less rigid from the insufficient amount of lime salts present, and thus readily bend under the weight of the body or from muscular action. Less frequently the subperiosteal compact bone becomes similarly rarefied (Fig. 184). In the Treatment of rickets the most essential feature in the early stages is the correction of all errors in the personal hygiene. The diet should consist of good cow's milk, diluted if need be, and with lime-water added ; whilst the juice expressed from raw beef, or one of the many meat juices now sold, may also be 528 A MANUAL OF SURGERY administered. The condition of the bowels must be attended to, and the child placed in as good surroundings as possible. Parrish's food (syr. ferri phos. co.) may be given by itself, but if the infant is thin and emaciated, cod-liver oil should be added. Deformities must, if possible, be prevented by keeping the child in the re- cumbent posture, and not allowing it to crawd or run about. The early stages of deformity can often be corrected by daily manipu- lation of the affected bones, and in the later stages they may be improved by suitable apparatus for immobilizing the limb, com- bined with pressure. Osteotomy, or even resection of portions of bone, is required in the severer cases where the deformity persists (see p. 400). Scurvy Rickets (Svu. : Acute Rickets, Hemorrhagic Rickets). — Attention has been directed of recent years, notably by Sir Thomas Barlow, to a curious condition met with in children, which seems to combine some of the most marked features of rickets and scurvy, but in which either one or the other set of phenomena may predominate. It is usually seen in the children of well-to- do people, and apparently arises from defective nutrition, especially from the prolonged administration of peptonized or prepared foods, together with an absence of fresh meat and vegetables. In the slighter cases there may be but little evidence of the scorbutic condition, beyond the fact that in a rickety child there is some tendency for the gums to bleed, or a little hematuria ; but in those that are more marked the rickety signs are of little importance compared with those due to hemorrhagic extravasations. The disease often comes on suddenly with some amount of pyrexia, rarely exceeding 102 F., but the child is evidently ill, and perhaps complains of tenderness of the limbs, which may be kept so quiet as to suggest that they are paralyzed. This is followed by the appearance of swellings of some size, due to subperiosteal extravasations, the skin over the affected parts being at first shiny and o^dematous, but subsequently becoming stained by the blood pigment. The femur and tibia are most often affected in this way, and the epiphyses may occasionally become detached, or even spontaneous fractures occur. Bleeding may also take place beneath the conjunctiva or into the orbit, leading to protrusion of the eyeball, whilst there may be blood-stained diarrhoea, hematuria, or epistaxis. The disease, when recognised, is readily amenable to treatment, but should its nature be overlooked, the child is likely to become emaciated and die. Attention to the diet is the main point to be attended to, for when fresh milk, lime-juice, or vegetables are given, the symptoms soon disappear. The affected limbs must be kept at rest, and cooling lotions applied, whilst splints are employed for separated epiphyses or fractures. Achondroplasia is the name given to a rare and curious congenital condition, somewhat resembling rickets, in which the growth of osseous tissue on the shaft side of the epiphyses of the long bones of both arms and legs is defec- tive, so that the limbs are short and stunted, and the stature correspondingly diminished, although the epiphyses are normal. The bones generally are not bent or curved abnormally, though there is probably some change of the neck or shaft of the femur, resulting in lordosis, which is very marked when the patient stands. The fingers taper to their tips, and are separated one from another in ' spoke-like ' fashion. The bones at the base of the skull, being of cartilaginous origin, undergo premature synostosis, whilst the upper half of the skull, being derived from membrane, and therefore developing naturally, looks unusually large ; the face is small and the bridge of the nose depressed as in congenital syphilis. The children, if they live, are usually efficient in DISEASES OF BONE 529 their mental development, and the thyroid body normal. No known treatment is of any value. Simple Atrophy of Bone. This results from a variety of conditions quite independent of rarefying inflammation, in which it is always a marked feature, (a) It maybe congenital, perhaps involving bones and soft tissues alike, (b) It may result from inter- ference with the epiphyses, as in rickets, or after injuries, or as a sequela to tuberculous or other inflammations involving the junction cartilage, (c) It may be due to injury or disease of the central nervous system or of peripheral nerves, as in tabes dorsalis, syringomyelia, leprosy, etc. (d) It maybe caused by want of use, as in a paralysed or ankylosed limb, (e) Local pressure, as of a tumour growing within or outside the bone, or of an aneurism, may deter- mine its existence, and possibly to such a degree as to result in spontaneous fracture. (/) It may be a senile change, as seen in the lower jaw, cervix femoris, or cranium. The type of atrophy varies with the cause. Sometimes it merely consists in an arrest of longitudinal development ; at others the bones are not only short, but smaller in all directions, and in leprosy may undergo almost total absorption. If the cause is localized, and acts from without, the compact bone is more or less cleanly eroded ; whilst if the cause is general, absorption may occur either from within, the medullary canal becoming enlarged and the compact tissue thinned, or from without, the cross-section of the bone gradually dwindling. The possible presence of atrophy must always be kept in mind when dealing with ankylosed or paralysed limbs, since very little force may suffice to produce a fracture. Mollities Ossium (Syn. : Osteo-malacia). This disease is one of somewhat unusual occurrence, characterized by the absorption of the osseous substance of the bones, as a result of which soften- ing and rarefaction are produced, followed by bending or spontaneous fracture. The complaint is almost limited to the female sex (only S per cent, of the cases reported are in males), and usually commences during pregnancy ; it is said to be sometimes connected with a rheumatic tendency. Any part of the skeleton may be affected ; in females the change usually attacks the pelvis, spinal column, and ribs first, and the limbs later ; in men the process starts in the long bones. Pathologically, the change consists in a replacement of the medullary substance by a soft fibro-cellular tissue, which is exceedingly vascular, and into which haemorrhage often occurs ; the resulting material looks in the fresh state something like splenic pulp. The bony cancelli are absorbed, as also the greater part of the compact tissue, with the exception of a thin layer situated beneath the periosteum ; in a well-marked case the mineral salts may be diminished to about one-sixth of their normal amount, but the relative propor- tion of phosphate of lime to the carbonate is not changed. Part of the bone substance remains for a time in a decalcified state, with the corpuscles evident, but in a condition of fatty degeneration. Probably some acid, e.g., lactic acid, is the active agent in dissolving the earthy salts, which escape partly in the urine, partly in the faeces. It is possible that the process is connected with the absorption of some internal secretion, normal or vitiated, particularly that from the ovary, an idea suggested by the fact that the removal of the uterine appendages has in a few cases stayed the disease. Clinically, the onset is usually somewhat indefinite, the only complaint being of pain in various parts of the body, whilst the patient becomes emaciated and exhausted. Sooner or later skeletal changes ensue and demonstrate the character of the disease. The limbs may either bend or break ; in the latter case there is often no attempt at repair. The pelvis becomes tri-radiate in shape owing to the acetabula being pressed inwards and backwards by the weight of the body, and in p.egnant women this may 34 53Q A MANUAL OF SURGERY cause so much deformity as to necessitate Caesarian section or Porro's opera- tion. Death may result from exhaustion, or from obstruction to parturition, or the patient may live more or less bedridden for years, the limbs becoming useless, shortened, and perhaps contorted in a strange and abnormal fashion. Treatment is unsatisfactory. Opiates may be administered to relieve pain, which is often very severe, and various drugs, such as alum, and phosphate or hypophosphite of lime, have been recommended. In cases not associated with parturition or pregnancy, oophorectomy is said to have been employed with benefit. The induction of premature labour is considered by some to be beneficial, not only for the sake of obviating the necessity for such operations as Caesarian section, but also on the chance of checking the disease. Hypertrophy of Bone. It is always a matter of difficulty to draw a definite line between a true hypertrophy and inflammatory or other overgrowths, and especially is this the case in connection with bones where chronic inflammation is always associated with new bone formation. Two or three conditions to which the term hypertrophy is perhaps more correctly attached may, however, be mentioned, (d) It is sometimes congenital ; if involving a whole limb or any large portion of the body, it is known as Gigantism ; if merely affecting the fingers or toes, it is termed macrodactyly (p. 390). (b) It may follow inflammatory affections of bones, which are thereby left with an increased blood supply, e.g. , after acute osteomyelitis, which has not destroyed the epiphyseal cartilages ; in such cases the overgrowth is mainly longitudinal, (c) Increased growth of bones is associated with several diseases to be described immediately, viz., osteitis deformans, acromegaly, etc., and in these it is possibly due to the effect of some internal secretion. Osteitis Deformans. Osteitis deformans is an inflammatory disease of the osseous skeleton, first described by Sir James Paget in 1876. The onset is insidious, and the progress very slow. It is characterized by a painful overgrowth of the long bones, spine, cranium, and pelvis, which are also softened, so that those which bear the weight of the body become curved. It may commence in one bone alone, and then usually the tibia or femur, but more often many bones are affected at the same time. Attention may be drawn to the condition, either by the pain, which the patient at first considers to be rheumatic, or by the general enlargement and bending of the bones, or by the increased size of the head, necessitating the use of larger hats. The cranial overgrowth is eccentric in character, and the calvarium may become very thick ; the facial skeleton, however, is not much affected. The spine becomes markedly kyphotic (Fig. 185), the dorsal curve being increased, and the lumbar concavity obliterated ; it is nearly rigid from ankylosis of the vertebrae, and may be very painful. The head is carried forwards by the bend of the spine, the height is diminished, the shoulders are round, and the chest sunken towards the pelvis : the gait is slow and awkward The disease usually attacks middle-aged men ; its progress is exceedingly slow, the patient often living to an advanced age, or dying from some intercurrent malady. Some cases have terminated in multiple sarcomata of the bones. The structure of the osseous tissue is suggestive of inflammatory rather than degenerative changes. It is softer and more uniform in structure than usual, the difference between the cancellous and compact tissue being less defined ; the Haversian canals are large, and arranged irregularly, whilst the bony substance is chalky- looking. Differential Diagnosis. — From arthritis deformans, which it resembles by the attitude and gait of the patient, it is known by the absence of articular lesions, especially in the fingers, and the enlargement of the bones, notably of the DISEASES OF BONE 53» cranium. From acromegaly it is distinguished by the absence of enlargement of the hands, feet, and lower jaw. Treatment is most unsatisfactory, no remedy at present known having any control over the disease. Acromegaly. Acromegaly is a rare condition the characteristics of which were first described by Dr. Pierre Marie in 18S5. It is a general affection involving mainly the osseous system, commencing usually in young adults, and, after Fig. 185.— Osteitis Deformans. (Bryant.) lasting for a long time, killing the patient by syncope or cerebral compression, if some intercurrent malady does not destroy him. It is characterized by a very definite enlargement of the hands and feet, which are, however, not lengthened, so that the hands have been compared to battledores, and the fingers to sausages. The bones themselves are enlarged, and the soft structures on the palmar aspects project as pads. The nails and skin are unchanged, whilst the other segments, both of the upper and lower limbs, are usually unaffected, though sometimes considerable over- growth in length occurs ; in fact, many of the so-called giants who have been exhibited are typical illustrations of acromegaly. Both the upper and lower jaws are thickened and prominent, whilst the lower lip is enlarged and over- hanging. The orbital ridges project, and the forehead is usually low ; the nose and tip of the tongue are also more or less enlarged The spine is kyphotic in the dorsal region, with a slight lumbar lordosis. The ribs and sternum project anteriorly. The patient usually suffers from headache, lassitude, and great fatigue, wandering pains about the body, and excessive appetite and thirst ; amenorrhcea is a marked symptom in women, whilst men suffer from a loss of virile power. The urine is abundant, but cf a low specific gravity. Vision is usually diminished, and optic neuritis has been observed in some cases. Morbid Anatomy. — But little is known as to the cause or pathological changes occurring in this disease, beyond the fact that the anterior glandular 532 A MANUAL OF SURGERY half of the pituitary body is hyper trophied, and the sella turcica expanded. The. changes in the bones are merely those of overgrowth. Diagnosis. — The disease has been mistaken for myxasdema, but there is not much difficulty in distinguishing the two if it be remembered that, in the latter condition, the skin is not mobile over the thickened subcutaneous tissue, that the face is broad, pasty, and puffy, and that masses of gelatinous tissue are found above the clavicle, whilst in acromegaly the face is elongated, and the skin and subcutaneous tissues normal. The mental condition and speech of a patient suffering from myxoedema are widely different from those in acromegaly ; whilst in the former the thyroid body is either absent or diseased, and in the latter skeletal changes are present. From chronic osteo- arthritis affecting the hands, the diagnosis is easy, in that there are usually no signs of articular disease, and much less pain. From osteitis deformans, the distinguishing features have already been indicated. Treatment is merely symptomatic, antipyrine being useful in relieving the headache, as also valerianate of caffeine. Possibly thyroid extract may be of some use in combating the functional phenomena, though it will not influence the skeletal changes. Fig. i85. -Head of Woman with Acromegaly, AND FROM THE SlDE.* Seen from the Front Another curious affection which has been recently described is that known by the formidable title of Hypertrophic Pulmonary Osteo-arthropathy. It has been long known that clubbing of the terminal phalanges was a common accompaniment of chronic pulmonary disease ; but this new affection is more extensive. The terminal phalanges of the fingers and toes are enlarged and bulbous, with the nails curved over them towards the palm or sole ; there is also a considerable swelling of the bones just above the wrists and ankles, and possibly a similar condition around other joints. The spine is kyphotic in the upper dorsal region, but with well-marked lordosis below. It is thus seen that the changes are somewhat like those of acromegaly, from which they are distinguished by (a) the implication only of the terminal phalanges ; (b) the swellings above the wrists and ankles ; and (c) the absence of the characteristic deformities in the skull and head. These phenomena probably result from a chronic osteitis, due to toxic absorption, since the condition arises in such * Reproduced from the Edinburgh Medical Journal, by kind permission of Dr G. A. Gibson. DISEASES OF BONE 532 diseases as chronic bronchitis, bronchiectasis, and chronic empyema, where suppuration has existed for some time. Little can be done in the way of treatment, except to remove the cause. Tumours of Bone. Many different types of tumours grow from bone. The characters of the osteomata, chondromata, and fibromata have been described in Chapter VII., and various solid and cystic tumours connected with the teeth are dealt with elsewhere. Sarcoma is the most important primary tumour of bones, and almost any form may occur. The microscopical characters have been detailed in the chapter on tumours, and we shall here only Fig. T.87. — Endosteal Sarcoma. (King's College Hospital Museum.) refer to their clinical characteristics. They may be divided into two main groups — the endosteal or central, and the periosteal. Endosteal or Central Sarcoma (Fig. 187) of bone commences in the medullary cavity or cancellous tissue, and results in the so- called ' expansion of bone,' which consists in absorption of the bone from within, whilst at the same time new osseous tissue is being deposited from the under side of the periosteum, though in these cases only to a limited degree. The Symptoms at first resemble those of chronic osteo-periostitis, although in most cases of tumour there is rather less pain. The growth usually com- mences near the end of a long bone ; it seldom encroaches on the articular cartilage, so that the joint escapes, although it may contain an excess of serous fluid ; occasionally, however, the growth may extend laterally beyond the level of the cartilage, and thus invade the articular cavity. Spontaneous fracture is not an unfrequent complication, and owing to the expansion of the bony 5 A MANUAL OF SURGERY framework ' eggshell crackling ' is sometimes met with. After a while, the growth may extend beyond the osseous limits into the soft parts, and then the chances of general dissemination are con- siderably increased. The chief varieties of sarcoma growing from the interior of long bones are the round or spindle-celled, and the myeloid. The two former early diffuse themselves throughout the medullary cavity, and infect neighbouring tissues and the system generally. Not unfrequently cartilaginous nodules may be found scattered through the mass. Myeloid tumours are almost benign in character, never giving rise to secondary deposits, either in lymphatic glands or viscera, and their growth within the bone Fig. 188. — Periosteal Sarcoma. (Bryant.) is limited to the region from which they originated ; sometimes a layer of condensed bone forms a definite barrier to check any advance along the medullary canal. The sites of election for myeloid tumours are the lower ends of the femur and radius, and the upper ends of the tibia and humerus — that is, where the growth of the limbs is greatest ; they also grow within the hori- zontal ramus of the lower jaw and the diploe. Not uncommonly a fibro-sarcomatous epulis is myeloid in nature. In considering the nature of an endosteal sarcoma, it should be remembered that myeloid tumours grow more slowly than the round- or spindle-celled, and are more likely to develop cysts owing to haemorrhage into their substance. In all of them a certain amount of bony skeleton may pervade the growth. DISEASES OF BONE 535 The Periosteal Sarcomata (Fig. 188) are round- or spindle- celled in nature. They often grow very rapidly, without giving rise to much pain, unless causing erosion of the bone. They usually start on one side of the bone, but later on may surround its whole circumference. They spread rapidly along its exterior, and are highly malignant in nature, giving rise to secondary growths in the neighbouring lymphatic glands or in the viscera. They frequently become ossified, with or without the development of cartilage, and in such cases the subjacent bone becomes sclerosed and thick. The bony skeleton of such a growth is very character- istic, consisting of fine spiculated trabecular, radiating more or less regularly from the surface, and looking in the dried state somewhat like asbestos. When a periosteal sarcoma does not become ossified, the growth usually erodes the underlying bone, and may lead to spontaneous fracture ; the tumour in such cases is softer and more elastic than in the former variety. All osseous sarcomata are exceedingly vascular, and may even pulsate, whilst the superficial veins are obviously dilated beneath the stretched integument, giving rise to a blue network. The Diagnosis of osteo- sarcoma in the early stages is often a matter of the greatest difficulty. The endosteal form may easily be mistaken for chronic osteo-periostitis, medullary gumma, or a deep abscess of the bone, and can sometimes only be distinguished from them by an exploratory incision, which should always be undertaken in doubtful cases prior to radical operations, such as amputation. In the later stages, the presence of ' eggshell crackling ' or cystic change will help to make evident the nature of the disease. The periosteal form may at first be looked upon as a periosteal node, or a deeply placed abscess. The rounded and definite edge of the growth, its irregular consistency, and the history of the case, will assist in the determination of its nature ; but in the early stages an exploratory operation is not unfrequently necessary. For the diagnosis of a pulsating sarcoma from an aneurism, see p. 261. When either form involves the articular end of a bone, especially the lower end of the femur, it may simulate tuberculous disease of the adjacent joint. It will, how- ever, be noted that the centre of the swelling corresponds to a point well above or below the joint, that a certain amount of movement is possible, and even without pain, whilst the starting pains at night characteristic of joint mischief are absent. The age of the patient, and the presence or not of cachexy, are also important features which have to be taken into consideration. Skiagraphy serves in some cases as an important diagnostic adjuvant. The Treatment of osteo-sarcoma must always be of a radical nature, and, remembering the highly malignant character of many of these growths, we would strongly urge the importance of an early exploratory operation in doubtful cases ; if undertaken. 536 ./ MANUAL OF SURGERY with antiseptic precautions no harm can ensue, and a definite diagnosis is thereby possible. If the case is left until increased growth reveals the true state of affairs, it is more than likely that, except in the myeloid variety it will be too late for successful operative interference. In every form of the disease except the myeloid, the affected limb should be removed high above the tumour. Thus, if growing from the lower end of the tibia, dis- articulation at the knee-joint should be performed ; if at the upper end of the tibia, amputation through the middle or lower third of the thigh ; if from the lower end of the femur, amputation through the upper third of the bone, if not at the hip-joint. For sarcoma of the head of the humerus, disarticulation through the shoulder- joint may suffice, but it is often wiser to remove the scapula and greater part of the clavicle as well (interscapulo-thoracic amputa- tion). The results of the latter proceeding, as regards final cure, have been much more satisfactory than those of the former. When muscular bellies have been invaded, it is desirable, though not always practicable, to include the whole of them in the scope of the operation. Myeloid sarcomata being practically non-malignant, except locally, are dealt with in a much more conservative manner, amputation through healthy tissue just above the growth being all that is necessary. It is advisable that the medulla at the point of section of the bone should be examined microscopically before the wound is closed, to make certain that it has not been invaded. When affecting the lower end of the radius, an attempt may be made to save the limb by excising the diseased portion of bone ; if a portion of the ulna is also taken away at the same time, there is less chance of the hand being drawn up and abducted, and hence it is more likely to become useful. A leather gauntlet to steady the part subsequently will almost certainly be required. Central sarcoma of the lower jaw, if myeloid in nature, may be treated by making a free opening in the bone, scraping the diseased tissue away, and swabbing out the cavity with pure carbolic acid. The continuity of the jaw may thus be maintained, even if the teeth are lost. Several successful cases treated ac- cording to this plan have been recorded. Secondary Sarcoma of bone is by no means uncommon. It is usually endosteal in character, and, except in the most unusual circumstances, will not demand treatment, owing to the general infection of the system. Possibly where it has led to spontaneous fracture, and there is much pain owing to the difficulty of fixation, it would be justifiable to remove the limb. Carcinoma of bone is always secondary in nature, although it may be involved by direct extension in a primary growth. It may occasionally lead to spontaneous fracture, but the bone may consolidate again satisfactorily. DISEASES OF BONE 557 A rare form of secondary carcinoma of bone is that known as Thyroid Cancer. The primary growth is in the thyroid body, whilst the secondary deposits in the bone are exactly similar in structure to it, and usually pulsate strongly. Pulsating Tumours of Bone, or Osteo-ar.eurism. — Not a few cases of sarcoma of bone, whether central or peripheral in character, have an evident pulsation, owing to their extreme vascularity, the thin-walled vessels in their substance being even dilated and aneurismal. Apart from these, two other conditions are met with, the nature of which cannot be considered as yet settled, in which distinct pulsation is also noticeable. In the first of these the medullary cavity is occupied by a non-malignant vascular tissue, practically identical with what we have already described as an aneurism by anastomosis. A large number of small arterioles open into spaces without the interven- tion of capillaries, so that an erectile tissue similar in nature to the corpus cavernosum penis results. Such tumours are situated most frequently in the cranial bones, and may be multiple, the medullary tissue being in consequence atrophied, and the compact tissue thinned, so that ' eggshell crackling ' may be obtained. The second form is found most commonly in the upper end of the tibia, or some such cancellous mass. It consists of a hollow cavity formed in the cancellated tissue, and filled with blood. Several distinct arterial twigs may open into it, and the overlying bone is thinned and absorbed. It is probable that the majority of such cases are in reality due to the breaking down of sarcomata of extreme tenuity. The Diagnosis of these conditions from an ordinary aneurism is alluded to elsewhere (p. 261) ; but it is often impossible to distin- guish one form of pulsating tumour of bone from another without an exploratory incision. The Treatment of these cases necessarily varies with the con- dition found after the preliminary incision into its substance, which should always be made after rendering the limb bloodless. Where it seems probable that the condition is not associated with malignant disease, or is merely due to a myeloid tumour, the cavity should be well scraped, swabbed out with pure carbolic acid, and then firmly stuffed with gauze, so as to obtain healing by granulation from the bottom. In other cases amputation is the only treatment. Hydatid Disease of Bone. — The cancellous tissue of bones occa- sionally becomes the site of hydatid development, any part either of the medullary cavity or of the ends being involved. The bone becomes expanded, with all the symptoms of an endosteal growth. Considerable deformity may occur, and when the compact layer has become sufficiently absorbed, spontaneous fracture may follow. 538 A MANUAL OF SURGERY A peculiar characteristic of this affection is that there is no limiting cyst wall, the small daughter cysts being diffused widely throughout the affected area. A diagnosis is little likely to be made (at any rate, in this country, where hydatid disease is so rare) prior to an exploratory incision. Treatment. — If all the cysts can be removed without interfering with the integrity of the shaft, a recovery, with good subsequent utility of the limb, should follow. Where, however, the disease has encroached widely on the bony tissue, whether spontaneous fracture has occurred or not, amputation holds out the only prospect of cure. CHAPTER XIX. INJURIES OF JOINTS— DISLOCATIONS. Sprains and Strains. — -When some of the ligamentous fibres around a joint are ruptured or stretched, as the result of sudden violence, the joint is said to be sprained or strained. The acci- dent itself is associated with severe pain, and is immediately followed by more or less haemorrhage into the surrounding tissues, or into the articular cavity. An attack of synovitis, varying in severity, generally ensues, and may lead to persistent weakness and pain in the joint, either from the formation of adhesions, or from imperfect repair of the ligaments. If this con- dition is neglected, it may originate tuberculous disease in those who are so predisposed, whilst osteo-arthritis is a by no means uncommon sequela. If the patient is in a bad state of health at the time of the injury, it is possible that an attack of acute infective arthritis may be lighted up. Treatment. — The joint should be firmly supported by a bandage as soon after the accident as possible, and cold or evaporating lotions applied. In the slighter cases, all that is needed is to strap the joint or use elastic pressure, the patient being allowed to use the limb at the end of a day or two ; but in severe sprains it is better to keep the part absolutely at rest for some days, since neglect in the early stages may give rise to as much, if not more, trouble than if the limb had been fractured. Friction with stimulating liniments^ massage, and douching the joint alternately with hot and cold water, are subsequently useful in restoring the limb to full func- tional activity. When synovitis supervenes, the treatment suit- able for that condition must be adopted. Penetrating Wounds of Joints are often accompanied by an escape of synovia, which is recognised as a glairy, oily fluid, floating perhaps on the surface of the blood ; if, however, the aperture is small, this may not occur. It is always followed by a certain amount of inflammation, the severity and extent of which depend on whether the joint is infected and the character of that infection. If no infection has taken place, and the joint is main- 540 A MANUAL OF SURGERY tained in an aseptic condition, a simple synovitis ensues, and soon passes off; if, however, micro-organisms have entered, acute arthritis probably supervenes, leading to destruction and dis- integration of the joint. (For symptoms and treatment, see Chapter XX.) A penetrating wound, even if untreated, does not necessarily become septic ; thus, if the lesion is produced by a small clean instrument, and especially if this is inserted in a slanting direction, so that the wound is valvular, or if the incision is a large one, allowing free vent to all discharges, recovery with- out septic inflammation is possible. Considerable difference of opinion has been expressed as to the necessity for accurately determining whether or not the synovial membrane has been involved. Speaking generally, one would recommend that if the wound is small, and the surgeon has reason to believe that the instrument inflicting it has been aseptic, the external skin should be thoroughly purified, and an antiseptic dressing applied. A careful watch must be kept upon the con- dition of the joint, and upon the temperature of the patient ; as soon as any signs of acute arthritis manifest themselves, free incisions are made into the joint, so as to relieve tension and allow the cavity to be irrigated. If, however, the wound is inflicted by a dirty instrument, and there is but little doubt that the joint has been penetrated, it is most important to make certain of this fact. For this purpose the wound should be enlarged, so that its depths may be purified, and then carefully examined. If it is found that the cavity has been opened, the aperture should be increased in size so as to allow it to be washed out and a drainage-tube inserted ; if acute arthritis supervenes, it must be treated in the usual way. Dislocations. Although the term ' dislocation ' is most commonly applied to a forcible displacement of one of the bones entering into an articula- tion, as the result of an injury, it must not be forgotten that con- genital and pathological displacements also exist. Congenital Dislocation. — This term is applied generally to any defect of a joint present at birth, but is really a misnomer, since the condition is almost always due to an error of development, as a result of which a normal location of the bony constituents has never been present, and hence a dislocation cannot have taken place. The hip-joint is most frequently affected ; but similar malformations have occurred in the shoulder, wrist, and jaw, whilst the patella may be congenitally absent or displaced. Congenital Dislocation of the Hip is by no means rare, although its causation is still quite uncertain ; probably it is due in some cases to malposition of the foetus in the uterus or to some irregu- larity in the shape of the uterine wall, e.g., such as results from INJURIES OF JOINTS— DISLOCATIONS 54i the presence of fibroids. The malformation is frequently bilateral, more commonly unilateral. It often passes unnoticed until the child begins to walk, and then the characteristic signs become evident. The limb is shortened and flexed on the pelvis, owing to the traction of the ilio-psoas muscle, necessitating a consider- able amount of lordosis to maintain the body in a vertical position (Fig. 191), whilst scoliosis is well marked in one-sided cases. Since the head of the femur is displaced from the middle line, a Figs. 189, 190. — Congenital Dislocation of Both Hips in a Girl of Fifteen Years, seen from the Front and Back. (From Photographs KINDLY LENT BY Mr. J. JACKSON CLARKE.) gap is usually noticed between the thighs close to the perineum. Considerable adduction of the lower end of the femur (Figs. 189 and 190) may result from muscular contraction (adductors), and in bilateral cases a scissor-leg deformity may ensue. The patient's gait is of a curious waddling character, which becomes very marked if one side alone is affected. Since the head of the bone is only maintained in position by its ligamentous and muscular attachments, it can often be drawn down at first, and the leg thus lengthened to the extent of an inch or two ; moreover, it is often 542 A MANUAL OF SURGERY easy to rtduce the displacement and put the head of the bone in the acetabulum in children that have not walked much. It is sometimes necessary to invert, sometimes to evert, the limb, as well as make traction, in order to accomplish this, the head of the bone not being always in the same place. At a subsequent date strains to the limb are almost entirely borne by the ligamentous tissues, and hence attacks of synovitis are common. The Pathological Anatomy varies con- siderably according to whether or not the child has walked. At bivth the head and neck are sometimes nearly normal, although the head is often rather small and perhaps flattened at the spot where it rests against the innominate bone, and the neck is short and stunted. The liga- mentum teres is long, thin and usually somewhat flattened. The acetabulum is smaller and more shallow than usual, but can usually receive the head of the bone, though it cannot retain it : this is stated by Lock wood to be due to the absence of the cartilaginous rim, but this explanation is certainly not true in all cases. The capsule is large and roomy. After the child has walked, sundry modifications make themselves evident. The head of the bone becomes more and more displaced, so that it may finally lie well above the acetabulum on the dorsum ilii (Plate XXVI.). The capsule becomes stretched over the displaced head, and much thicker than usual ; the ligamen- tum teres is flat and band-like. The head of the bone is considerably altered in shape ; the defective development of the acetabulum is more obvious, since it becomes triangular in shape, owing chiefly to want of growth of the iliac portion, whilst the muscles are necessarily modified as to their length. A new, but very imperfect, acetabulum forms on the spot where the head of the bone usually rests. Treatment. — Should a diagnosis be made before the child has commenced to walk, there is no reason why treatment should not be instituted at once. The head of the bone can usually be placed in its socket, and is kept there by fixing the limb in a position of abduction, whilst inward pressure is made over the trochanter with a screw apparatus. Schede has by this means converted the unstable articulation into a stable one. Such treatment will Fig. 191. — Side View of Same Patient to show the Extreme Lordosis. PLATE XXVI. INJURIES OF JOINTS—DISLOCATIONS 545 last from six to twelve months. Others have effected the same result by prolonged traction. At a later age (up to five or six years) Lorenz's bloodless method of treatment may be employed with good hopes of a successful issue in unilateral cases. (1) The head of the bone is first drawn down to the level of the acetabulum. Some surgeons recommend this to be effected by gradual extension ; others do it at one sitting under an anaesthetic. The adductor muscles are the chief hindrance, and will require a good deal of kneading, or even possibly section with a tenotome. (2) The head of the bone is to be replaced in the acetabulum, and as this cavity is small and chink-like, and sometimes covered in by the front of the capsule, a good deal of difficulty may be here experienced. The limb is fully flexed and then forcibly abducted, extended and everted, no undue violence being permissible, or the bone may be fractured. The head of the bone can sometimes be felt to slip into the acetabulum, and the manoeuvre should be repeated several times, as it were, grinding the head of the femur into the acetabulum. (3) The limb is then put up in plaster of Paris from the pelvis to the knee in a position of abduction and slight eversion, and with the leg flexed. It is maintained in this position for ten or twelve weeks, and it is well to ascertain by skiagraphy that the bone has not slipped. At the end of that period it will probably be found that a less degree of abduction will suffice in order to keep the bone in place, and a fresh case of plaster is applied with the limb in this new position, the extension and out- ward rotation being maintained. As soon as possible the child is encouraged to walk on the limb in this position of abduction, so as to force the head of the bone still deeper into the acetabulum ; crutches are required at first, but he will soon do without them. The plaster casing is usually needed for six months. In older children (from five to ten years) operative treatment can be undertaken with some prospect of success. Hoffa and Lorenz have been the great exponents of this proceeding, though for children under five years they both admit the value of the bloodless method. Their operations consist in opening the joint from the back and front respectively, shaping up the head of the bone, enlarging the acetabulum so that the head can be replaced in it, and dividing any tense structures which prevent reduction. The limb is subsequently immobilized in a position of eversion and abduction, but for as short a time as possible. Even if anky- losis results, the patient's gait is considerably improved. Pathological Dislocations are produced as the result of some intra-articular affection, e.g., tuberculous disease, osteo-arthritis, Charcot's disease, etc. It is unnecessary to describe them here. 544 A MANUAL OF SURGERY Traumatic Dislocations. Causes. — These are divided into the predisposing and exciting. Under the former head may be included some anatomical pecu- liarity of the joint, such as the shallow socket of the glenoid cavity, or some weakness of the muscles or ligaments which control the movements of the articulation. Dislocations are rare in children, since any violence directed to a joint or its neighbourhood is more likely to lead to an epiphyseal separation. Moreover, in old people the bones become brittle, and thus fractures, rather than dislocations, are produced ; hence the later lesions are almost limited to adults, and, owing to their greater exposure to injury, occur in men rather than in women. The Exciting Causes are the application of external violence and muscular force, acting alone or in combination. The former may be direct, but is more commonly indirect, the force being applied at a distance from the joint. Muscular action by itself can only produce dislocation in certain joints, which by their peculiar con- formation are predisposed to it ; the head of the humerus, the patella and condyle of the jaw are the bones most often affected in this way. If, however, the ligaments of a joint have been stretched by previous disease or displacement, recurrent disloca- tions, the result of muscular action, are not unusual. The term complete dislocation, or luxation, is applied to that con- dition in which the articular surfaces of the bones are completely separated from one another. An incomplete dislocation, or subluxa- tion, is one in which the surfaces are only partially separated. A compound dislocation is one in which the skin has been ruptured and a communication established with the external air. A com- plicated dislocation is one in which there has been some associated injury of vessels, nerves, or viscera. The term fracture-dislocation is one applied to a condition in which a dislocation is complicated by fracture of one or both bones involved. The Signs of a dislocation are as follows : (i) The evidences of a local trauma, e.g., pain, bruising, and swelling of the soft tissues, due to their laceration and the effusion of blood into them ; the amount of this varies in different cases : (2) deformity of the limb due to the articular end of the displaced bone being in some abnormal position, where it can often be felt and sometimes seen : and (3) restricted mobility of the affected joint, and hence impairment of function of the limb. The degree to which this obtains is necessarily variable, but, as a rule, it is very marked ; if, however, fracture is also present, passive movements may be possible, though associated with pain and crepitus. The Effects produced by a dislocation extend to all the struc- tures entering into and surrounding the site of injury. The liga- ments are partially or completely torn ; the bony surfaces are not unfrcquently fractured, especially in closely-fitting hinge joints, INJURIES OF JOINTS— DISLOCATIONS 54 5 such as the elbow and ankle ; the cartilages may be bruised, or portions of them detached, and neighbouring muscles and tendons lacerated and displaced ; adjacent vessels and nerves are often contused or compressed. Considerable effusion of blood is always present, infiltrating the whole area involved. The character of the injury explains the difficulties that are met with in its reduction. These arise from two main causes : (a) The anatomical structure of the joint and its ligaments, re- sulting in the hitching of bony prominences against one another, whilst the head of the bone does not always lie opposite the hole in the capsule through which it originally passed. In a few cases A B Fig. 192. — Old-standing Suecoracoid Dislocation of the Shoulder, show- ing Atrophy of True Glenoid Cavity, together -with Formation of New Joint and Alteration in Shape of Head of Bone. A, View from the Front ; B, from the Outer Side. (From College of Surgeons' Museum.) the end of the bone may be grasped by neighbouring ligaments and muscles in such a way as to render its replacement a matter of the greatest difficulty. (b) Muscular contraction also con- stitutes an obstacle, which, though formerly difficult to counter- act, is now readily overcome by the use of anaesthetics. Not only does the patient maintain the limb in a condition of rest by a voluntary tonic contraction, but it becomes fixed by the involuntary passive tension of the displaced muscles. Moreover, clonic spasms may arise from the direct or reflex irritation of nerves, and these the patient is quite incapable of controlling. When once reduced, Nature soon restores tiie part, so that in many 35 546 A MANUAL OF SURGERY cases no permanent lesion remains, although in some the rent in the capsule does not heal firmly, leaving the joint weak and liable to a recurrence of the displacement, while intra-articular adhesions, or the cicatricial contraction of the injured ligaments and muscles, may cause some loss of mobility. If a dislocation is allowed to remain unreduced, the true articular cavity becomes shallow and partly filled up by a transformation of its cartilage into fibrous tissue, whilst the displaced head of the bone becomes adherent to the structures amongst which it lies ; as the result of a plastic inflammation, either dense fibrous adhesions are formed, or a new false joint (psetidarthrosis). The articular cartilage is eroded, and the exposed bone eburnated and sclerosed, whilst, owing to chronic periostitis, the end of the shaft may be considerably deformed. The portion of bone upon which the displaced head rests undergoes changes, partly atrophic (from pressure), partly hypertrophic (as a result of chronic periostitis), whereby a new socket is produced (Fig. 192). Neighbouring muscles are secondarily shortened, and accommodate themselves to the abnormal position of the limb, and tendons which have been torn gain fresh attachments. These changes necessarily interfere more or less seriously with the power of the limb and the movements of the joint. Treatment. — The treatment of dislocations consists in the re- duction of the displaced bone with as little delay as possible. There are two chief methods of gaining this end, viz., manipula- tion and extension. Manipulation is always the best means to employ where practicable, less injury being sustained by the surrounding tissues. It consists in moving the limb in such directions as shall cause the displaced end to retrace the course that it has already taken, through the rent in the capsule to its normal position. The shoulder and hip joints are more amenable to this method of treat- ment than hinge joints. Anaesthesia will be required in difficult cases. The special manipulations needed in any particular instance are detailed under the various joints. Extension is employed to overcome muscular and other forms of resistance, so as to draw the bone back into its original position. In order to make this effectual, the parts above the dislocation are steadied by some counter-extending force applied either by the hands of an assistant, or by a belt or towel, or by the knee or foot of the surgeon. Extension may be made by the hands, or a firmer grip may be maintained, and greater force used, by apply- ing a bandage or a jack-towel to the limb by means of a clove- hitch. In a few cases, the force may be exerted through some form of multiplying pulley, fixed at one end to a hook or staple, and at the other end to the loop of a towel or bandage attached to the limb. When any such contrivance is employed, precau- tions must be taken to prevent the soft tissues from being injured. INJURIES OF JOINTS— DISLOCATIONS 547 A useful plan consists in applying a damp bandage at the point from which traction is to be made, and over this a thick skein of worsted in the form of a clove-hitch, the loop being attached to the hook of the pulley. The extension must be made continu- ously ; no jolting or jerking action is allowable, or considerable mischief may ensue. Since the introduction of anaesthetics, how- ever, pulleys have been very rarely required, except in dealing with old-standing cases. Reduction, however produced, is usually accompanied by a sudden and distinct snap or suction sound, due to the contraction of muscles, unless the patient is deeply under an anaesthetic, and the muscles are absolutely relaxed. The limb is subsequently kept at rest for some days, to allow the rent in the capsule to heal. Cooling lotions are applied to reduce the swelling, and at the end of ten days or a fortnight passive movements commence, together with friction and massage of the soft parts. The treatment of unreduced dislocations is often a matter of con- siderable difficulty. Attempts to reduce them may be undertaken up to two or three months, but no undue violence is permissible, owing to the fact that adhesions to neighbouring parts may thereby be ruptured, and the main vessels or nerves endangered. The use of pulleys has been sometimes recommended, but so many accidents have been reported, varying in severity from laceration of the skin to actual avulsion of the limb, that it is better to dis- continue such treatment if it has failed on its first application. The amount of mobility possible in an unreduced dislocation varies a good deal in different cases, and the character of the treatment is mainly governed by this. If movement is tolerably free, and not particularly painful, massage and manipulation may be undertaken, and a very useful limb result. Where, however, movement is both painful and limited, operative treatment should be undertaken ; subcutaneous section of muscles and tendons has been practised, but without much success, and the risk, owing to the fact that the peri-articular structures are displaced and dis- torted, is so great as to render such a procedure unadvisable. Two chief methods of operative treatment are applicable : (i.) Re- duction by an open operation. The head of the bone is cut down on, and freed from its adhesions to surrounding structures, the capsule of the joint being also opened, and the cavity cleared; reduction may then be possible by means of manipulation or extension. A few cases of successful treatment of old-standing dislocations of the shoulder by this means have been recorded ; but, as a rule, the gain derived thereby is not commensurate with the risks and difficulties of the operation, especially if a considerable interval has elapsed since the accident, (ii.) Excision of the displaced head of the bone will give the best result in most cases. In the elbow- joint it is often the only practicable treatment, and in the shoulder and hip it is usually better than attempting open reduction. 54 8 A MANUAL OF SURGERY Compound dislocations are almost always serious lesions, for not only is the skin lacerated, and the joint exposed to the risk of septic contamination, but adjacent vessels and nerves are liable to injury. Unless efficient treatment is adopted, suppurative arthritis ensues, leading to disorganization of the articulation with subsequent ankylosis, or, in the case of larger joints, possibly to death from pyaemia and septic poisoning. The treatment consists of the application of the principles of antisepsis already enunciated for the treatment of lacerated wounds, together with reduction of the dislocation. If necessary, the wound in the skin must be enlarged, in order to allow of the replacement of the bone, and, should the latter structure be much bruised or injured, it may be advisable to resect it at once. If, however, vessels and nerves are also injured, or if the patient is old or debilitated, amputation may be required. Special Dislocations. Dislocation of the Lower Jaw forwards is not a very common accident, and usually results either from muscular action, or from a blow on the chin when the mouth is widely open, as in gaping, laughing, or attempting to take a large bite. It has also been produced in dentistry by a violent strain during tooth-drawing, or from digging out roots with an elevator. In some persons the accident happens with the greatest ease, and constantly recurs, owing probably to laxity of the capsule or in- sufficient development of the eminentia articularis. The mechanism of the dis- location is as follows : When the mouth is opened, the condyle of the jaw slips for- wards on to the eminentia articularis, and it requires very little force to displace it still further into the zygo- matic fossa (Fig. 193). The inter-articular cartilage sometimes follows the condyle, and the attachment of the external pterygoid muscle to that structure and to the bone explains the occurrence of dislocation from muscular action. The displacement may be unilateral or bilateral, more frequently the latter. The mouth remains widely open, the teeth and the jaws being separated by an interval of about an inch. The lower jaw projects unduly, and is fixed, saliva dribbling over the lip ; speech and deglutition are impaired, the pronunciation of the labial consonants being especially difficult. A hollow can be Fig 193— Dislocation of Jaw. INJURIES OF JOINTS— DISLOCATIONS 549 detected immediately in front of the tragus, where the condyle is normally lodged, and in front of this hollow the condyle can be felt, being recognised by the slight amount of passive movement still possible. A finger inserted into the mouth may be able to make out the coronoid process in an abnormal position beneath the zygoma. When the dislocation is unilateral, the symptoms are much less marked. Some amount of movement of the jaw still remains, whilst the chin is displaced towards the sound side. Treatment. — The reduction of the bone is in most cases easily effected. All that is needed is to depress the condyle below the level of the eminentia articularis, when the masseter, temporal and internal pterygoid muscles speedily draw it back into the glenoid cavity. The patient is seated in a chair ; the surgeon standing in front guards his thumbs with thick napkins to prevent being bitten, and introduces them into the mouth, pressing upon the lower molar teeth. Pressure is continued in a downward and backward direction until the condyle is free, and then the chin is raised by the fingers on either side. The jaw is kept at rest for a few days by means of a four-tailed bandage. A few cases are on record of displacement of the condyle of the jaw backwards, associated with fracture of the tympanic plate and tearing or separation of the cartilage of the auricle, leading to bleeding from the ear. Displacement upwards into the cranial cavity through the roof of the glenoid fossa has also been described, the patient in one case dying of meningitis. Dislocation of the Sternal End of the Clavicle. — It might be supposed that displacement at this joint would not be uncommon, when the shape and relative sizes of its articular surfaces are con- sidered, together with the great strains to which it is subjected. Owing, however, to the strength of the ligaments surrounding it, particularly of the rhomboid, this is not the case, the clavicle being broken rather than displaced. The cause of such displacements is violence directed to the acromial end of the clavicle. If the force acts from in front, the bone may be thrown forwards ; if from above, downwards and inwards, the upward dislocation may occur ; if the shoulder is driven forwards and inwards, the head of the bone may pass backwards. Three varieties are described according to whether the head of the bone travels fonvards, back- wards, or upwards. In the forward dislocation the end of the bone lies on the anterior surface of the manubrium, where it can be easily de- tected ; all the ligaments of the joint are torn, except, perhaps, the interclavicular. The point of the shoulder is approximated to the middle line. Treatment. — Reduction is effected by placing the knee against the spine between the scapula?, and drawing the shoulders backwards, the elbow on the affected side being kept in 5 So A MANUAL OF SURGERY front of the mid-axillary line. The displacement is very likely to recur, and to prevent this a pad is kept over the end of the bone by a figure-of-8 bandage, whilst the point of the shoulder is pushed outwards by placing a pad in the axilla, and binding the arm to the side. It is advisable to keep the patient in bed for a few days, so as to give the ligaments a better chance of reuniting, but some amount of forward displacement is very likely to persist. No bad result follows, even should the dislocation remain unreduced. The backward dislocation is not often met with. The head of the bone lies behind the upper part of the sternum, close to the origin of the sterno-hyoid and sterno-thyroid muscles. All the ligaments are ruptured, including the rhomboid. A depression is felt in the usual position of the head of the bone, which may be sometimes detected lying deeply in the superior mediastinum. The shoulder is thrown forwards, and situated nearer the middle line of the body than usual, whilst the movements of the head and neck are painful and limited. Pressure of the bone upon the trachea, oesophagus, and vessels of the neck gives rise to diffi- culty in breathing and swallowing, whilst the consequent conges- tion of the head may even cause semi-coma. Reduction by exten- sion of the shoulders backwards is usually accomplished without much trouble. In cases of difficulty, a firm pad can be placed in the axilla, and the shoulder levered outwards by using it as a ful- crum, the elbow being pressed to the side. It is retained in position by keeping the shoulders well extended by the use of two hand- kerchiefs, as suggested in the treatment of fractured clavicle. If the condition cannot be reduced, and serious symptoms of pressure result, the head of the bone should be excised. The upward dislocation is one of ex- treme rarity. The head of the bone is felt in front of the trachea, in which situation it may compress both windpipe and oesophagus, especially when the patient sits up or leans forwards. To effect reduction, a pad is placed in the axilla, and the arm pressed inwards over it ; the elbow is subsequently bandaged to the side and well elevated. A pad is nov3^i ) c I ^ L A . CATI0N at the same time kept over the end of Downwards of Acromiom . • . . . . r . . , , from the End of the tne bone, but it is very probable that Clavicle. (Tillmanns.) some amount of displacement will persist. Dislocation at the Acromio-clavicular Joint consists in the acromion being forced either above or below the outer end of the clavicle, more commonly the latter. The displacement is easily INJURIES OF JOINTS— DISLOCATIONS 551 recognised by the abnormal prominence of one or other of the bones (Fig. 194). It usually results from violence directed to the scapula. No difficulty is experienced in reduction, but the dis- placement is very liable to recur, especially in the more common form. The elbow is then flexed to a right angle, and pads of lint or small towels placed over the acromion and beneath the elbow ; a bandage or strap is then applied over the shoulder and under the elbow, and suffices to maintain the bone in position. It is kept from slipping by passing a bandage under the strap round the opposite side of the chest. Should the displacement persist, and give rise to pain or impair the movements of the arm, the bones may be wired together after removing the cartilaginous surfaces. A condition is sometimes met with, described as a Dislocation of the Lower Angle of the Scapula, or, better, Winged Scapula. It is characterized by projection backwards of that part of the bone when the arms are thrust forwards ; and is due rather to paralysis of the serratus magnus and rhomboids than to slipping of the fibres of the latissimus dorsi from the lower angle, as was formerly supposed. In several cases we have noticed pain and tenderness over the roots of the 5th and 6th nerves in the neck, suggesting its dependence on a chronic neuritis of these trunks. A similar condition is sometimes noted in progressive muscular atrophy. The Treatment consists in the administration of strychnine, and the use of massage and of the faradic current, whilst, if per- sistent, a properly applied apparatus may correct the deformity. Dislocation of the Shoulder occurs almost as frequently as all the other dislocations of the body put together. The shallowness of the glenoid cavity, the size of the head of the humerus, the laxity of the capsule, the extent and force of the movements possible, and the exposed position of the shoulder, explain the great frequency of the accident. It usually results from falls upon the hand or elbow, the arm at the time of the accident being widely outstretched, to enable the individual if possible to save himself. The weak lower and inner part of the capsule receives the chief portion of the shock, and yields, the head of the bone being primarily displaced downwards into the axilla (sub- glenoid variety), and then, according to the direction of the force, or the character of the subsequent manipulations, the head travels either forwards (subcoracoid or subclavicular dislocation) or back- wards (subspinous). Falls on the elbow or shoulder may, how- ever, cause a direct forward or backward displacement. The Signs of a dislocation of the shoulder are sufficiently obvious, and certain characteristic features are met with in almost all varieties. (1) The shoulder looks flattened, owing to displace- ment of the head inwards (Figs. 138, B and 197), and as a result of this the acromion process is unduly prominent, and a hollow felt below it, occupied by the tense deltoid. (2) The head of the bone 552 A MANUAL OF SURGERY lies in some abnormal position, and the glenoid cavity is empty. (3) The elbow is displaced away from the side, and it is im- possible to make it touch the chest wall at the same time that the hand is placed on the opposite shoulder (Dugas' test) ; this does not always obtain in the subcoracoid type. (4) The vertical measurement round the axilla is increased in all the varieties (Call- away's test) ; whilst inspection reveals a lowering of the anterior or posterior axillary fold (Bryant's test). (5) A ruler or straight- edge can be made to touch both the acromion process and the outer condyle of the elbow in most cases of dislocation (Hamilton's ruler test) ; this is impossible when the head of the bone is in its normal position, but can also occur in fractures of the anatomical neck. At the same time, the usual signs of a dislocation, viz., rigidity and local bruising, are also present. Fig. 195.— Subglenoid Dislocation Fig. 196.— Subcoracoid Dislocation of Shoulder. (Tillmanns.) of Shoulder. (Tillmanns.) Subglenoid Dislocation (Fig. 195) is the primary condition met with in all cases where the accident is due to a fall upon the out- stretched arm, but is not commonly seen, since the head of the bone usually slips up under the coracoid, as before stated. The head of the bone passes downwards into the axilla, resting against the outer border of the scapula below the glenoid cavity, between the subscapularis above and the teres minor below, whilst the long head of the triceps is placed behind. The capsular ligament and muscles passing to the tuberosities are lacerated, whilst the axillary vessels and nerves may be seriously com- pressed. The head of the bone is detected in the axilla, and the anterior axillary fold is much lowered ; the elbow is directed away from the side and slightly backwards ; the arm is lengthened, perhaps to the extent of 1 inch, whilst the forearm is usually flexed, and the fingers may be numbed from pressure on the nerves. INJURIES OF JOINTS— DISLOCATIONS 553 A few cases have been recorded in which the arm was abducted and displaced vertically upwards, although the head of the bone was in the usual position of a subglenoid dislocation. This variety is known as the luxatio erecta. Subcoracoid Dislocation (Figs. 196 and 197) is, without doubt, the most common form. In it the head of the bone lies under the coracoid process on the anterior part of the neck of the scapula, immediately in front of the glenoid cavity, the anato- mical neck impinging en its anterior border. In this position it Fig. 197. — Subcoracoid Dislocation of the Right Shoulder. is above the tendon of the subscapularis, which is either torn or stretched over the neck as a tense band, and may considerably impede reduction. Two forms of this displacement are described by Malgaigne, according to whether the muscles attached to the great tuberosity are intact, resulting in marked external rotation of the limb (subcoracoid variety), or whether they are lacerated, or even the great tuberosity itself pulled off, the humerus being then rotated inwards (intracoracoid variety). In both types the elbow is displaced backwards and outwards, and the head of the bone can be usually felt with ease, especially on rotation of the arm, under the outer third of the clavicle, except in stout people 554 A MANUAL OF SURGERY or where the muscles are greatly developed. Comparatively little alteration in the length of the arm is produced. The Subclavicular variety is very uncommon, and merely an exaggeration of the subcoracoid. The head of the humerus passes further inwards, and lies deeply under the pectoralis major, on the second and third ribs. The capsule and surrounding muscles are much lacerated, or perhaps the great tuberosity torn off; the elbow is markedly separated from the side and directed a little backwards, whilst distinct shortening is present. The Subspinous Dislocation (Fig. 198) is not frequently met with. The head of the bone lies in the infraspinous fossa, im- mediately behind the glenoid cavity, between the infraspinatus and teres minor muscles, the subscapularis being usually torn. Malgaigne states the head of the humerus is most commonly found resting on the posterior edge of the glenoid cavity im- mediately below the acromion process (subacromial variety). The elbow is dis- placed considerably forwards, but can be made to touch the chest wall ; the arm is rotated inwards, so that the hand is thrown across the front of the body. There is usually a marked hollow be- neath the coracoid process, whilst a distinct prominence is caused by the head of the bone in its false position. The length of the limb is frequently unaffected, or if any change is present, the arm is slightly lengthened. Three or four cases have been de- scribed of what is known as a Supra- coracoid Dislocation. The head of the bone is here displaced upwards, and either the coracoid or acromion process is broken, more commonly the former. Replacement with crepitus is easily obtained, but the dislocation is liable to recur. The Treatment of Dislocation of the Shoulder consists in reduc- tion by manipulation or extension. 1. For reduction by manipulation an anaesthetic is advisable, though not absolutely essential, and preferably chloroform, although where the patient is in a bad state for the administration — i.e., with his stomach full of food — ether may be preferable. It is only right to draw attention to the fact that a large number of fatal cases of chloroform administration have been reported as occurring in the treatment of shoulder dislocations ; this is due mainly to two causes, viz., the deep anaesthesia required, and the want of pre- paration of the patient. The greatest care must therefore be exercised in giving the anaesthetic. Many different methods of manipulation have been suggested, Fig. iq». — Subspinous Dis- location of Shoulder. (Tillmanns.) INJURIES OF JOINTS—DISLOCATIONS 555 of which the following are the more important. Not unfrequently, when the muscles are relaxed, any slight rotary movement suffices to ' put the bone in.' Kocher's Method. — The surgeon standing in front of his patient, who is seated or reclining, and supported by an assistant, grasps the elbow r after flexion of the forearm, and presses it to the side. The arm is now rotated firmly and steadily outwards until the forearm is at right angles to the body, when distinct resistance will be felt. This causes the head of the humerus to roll out beneath the acromion, and is often sufficient to effect reduction ; but if the limb is still displaced, the arm should be drawn forwards to the median line and elevated almost to a right angle with the trunk, with the hand still abducted and everted, whilst finally the arm is rotated inwards so as to carry the hand towards the opposite shoulder, and the elbow lowered. This plan is most useful in subcoracoid dislocations, and its value, according to Kocher, turns on the fact that the posterior part of the capsule and the scapular tendons inserted therein are usually untorn and stretched tightly across the glenoid fossa. Rotation outw r ards relaxes this structure and removes it from the fossa, whilst the rent in the capsule gapes, but owing to the fact that the upper and lower margins of the opening are still tight, the head of the humerus remains fixed against the neck of the scapula until the elbow is carried forwards and raised. The upper part of the capsule then relaxes, and the lower part which remains tense guides the head of the bone into the joint. Smith's Method varies somewhat in its application, according to whether the head of the bone is displaced anteriorly or posteriorly. For anterior displacements the surgeon stands in front of the patient, and grasps the shoulder, using the right hand for the right shoulder and the left for the left, so that the thumb rests on the head of the bone, and the fingers grasp and steady the scapula. With the other hand he seizes the arm near the elbow which has been flexed, and raises it from the side, extending and everting it. Having thus raised it to a right angle, the limb is steadily and continuously circumducted inwards, the thumb following the head of the bone and assisting it to reach the lower and under side of the capsule, and thus enter the socket through the rent. For the subspinous dislocation, the surgeon stands behind the patient and grasps the shoulder with one hand, raising the arm with the other, and making extension backwards combined with external rotation ; i.e., the limb is circumducted outwards, and finally brought to the side. 2. Extension may be made in different ways, the object of all, however, being to overcome the tension of surrounding ligaments and muscles. It may be applied directly downwards by the surgeon grasping and pulling on the arm, whilst his unbooted foot is used as a counter-extending force in the axilla, the patient 550 A MANUAL OF SURGERY lying flat on a mattress placed on the ground, and the surgeon sitting by the side. Another plan consists in using the knee as a fulcrum instead of the heel, the patient sitting in a chair. Occa- sionally the foot has been placed against the thoracic wall, and extension made directly outwards at right angles to the body, as recommended by Sir Astley Cooper. White, of Manchester, suggested vertical traction, the arm being pulled directly upwards, the surgeon's foot having been placed over the acromion, the patient being in the recumbent posture. The only objection to this last method, which may succeed when other plans fail, is that the axillary vessels are somewhat exposed to injury. Dislocations of the Elbow- Joint are not very uncommon, occur- ring particularly in young people, and are due to either direct or indirect violence. The diagnosis is often difficult from the amount of swelling that quickly follows. A careful investigation of the relative position of the bony points (p. 456), and of the degree of mobility of the different parts on each other, is essen- tial in order to arrive at a definite conclusion as to the exact nature of the lesion. In cases of doubt, a skia- gram should be taken. 1. Dislocation of Both Bones may occur either backwards, forwards, or laterally. The backward variety (Fig. 142 A) is that most often met with ; it usually occurs without either the coronoid process or the olecranon being frac- £H \ tured, although occasionally the former. Il\ I is detached. If the coronoid remains intact, it sometimes becomes locked in the olecranon fossa, and renders the arm immobile ; if, however, it is broken, considerable mobility of both Fig. 199.— Reduction of Back- bones occurs, with crepitus. The fore- ward Dislocations at the arm ; s sem i.flexed, the hand held mid- way between pronation and supination, and the displaced bones form a con- siderable swelling at the back of the joint, above which is a marked hollow, crossed by the triceps. The lower end of the humerus projects in front, and the artery and the soft parts are displaced forwards. The measurement from the acromion process to the external condyle remains unaltered, but that from the condyle to the styloid process of the radius is distinctly shortened, Elbow. INJURIES OF JOINTS— DISLOCATIONS 557 and the distance between the condyles and the olecranon process is increased. Dislocation forwards of both bones rarely occurs without fracture of the olecranon process, although a few cases of this unusual accident are on record. The displacement is readily detected, the forearm being lengthened perhaps to the extent of an inch. The arm is in a condition of flexion, and, indeed, the accident can only take place from falling backwards on the point of the elbow when in this position. The triceps muscle may be considerably lacerated. Lateral dislocations of the forearm are almost always incom- plete and are not very frequent ; the bones may be displaced either inwards or outwards, the latter being the more common. They are recognised by a careful examination of the relative position of the bony prominences. 2. Dislocation of the Ulna alone occurs only in a backward direction. It is an occurrence of the greatest rarity, owing to the position and strength of the orbicular and oblique ligaments and of the interosseous membrane. If, however, the bones of the forearm are rotated backwards upon the head of the radius as a fulcrum, and then the forearm adducted, this displacement can occur without extensive ligamentous lacerations, which, indeed, have not been noted in any of the cases observed. In the Treatment of the above dislocations, all that is neces- sary is to unhitch the interlocking bony prominences, so as to allow the bones to return to their normal positions by muscular contraction. This is usually ac- complished by the method de- scribed by Sir Astley Cooper. The patient being in a sitting position, the surgeon presses back- wards, with his knee in the bend of the elbow, against the lower end of the humerus; at the same time he grasps the patient's wrist, and slowly and forcibly bends the forearm (Fig. 199). 3. Dislocations of the Radius alone may occur either forwards, Fig. 200.— Dislocation of the backwards, or outwards. Radius Forwards. (Pick.) The forward dislocation (Fig. 200) is that usually seen, and results from falls on the hand when the forearm is in a state of extreme pronation. The head of the radius rests against the lower end of the humerus in the hollow above the capitellum, and the most characteristic feature consists in the inability of the patient to flex his forearm, owing to the bone impinging against the lower end of the humerus. It can be readily detected in this situation, rotating with the move- 558 A MANUAL OF SURGERY ments of the forearm, whilst a deep hollow is felt behind, imme- diately below the external condyle. The forearm is somewhat flexed, and midway between pronation and supination ; the former act can be satisfactorily accomplished, but supination cannot be carried further than half-way. A marked fulness exists on the anterior aspect of the limb when the arm is extended. Fracture of the upper third of the ulna sometimes accompanies this accident, especially when produced by direct violence (Plate XXVII.). If this luxation is not reduced, very great impairment of the mobility of the limb results, flexion beyond an obtuse angle becoming impossible. Treatment. — Reduction is accomplished by traction from the wrist, with the forearm flexed to a right angle, combined with pressure over the head of the bone. Owing to the fact that the orbicular ligament is ruptured, the deformity is very likely to recur, and hence active movements of the limb must be inter- dicted for three or four weeks ; a pad is placed anteriorly over the head of the bone, and the limb flexed on a splint. Dislocation backwards is less common. The head lies behind the external condyle on the outer side of the olecranon, where it can be detected on rotating the limb (Fig. 201). The forearm is flexed, and the limb pronated. Even if left unreduced, it leads to but little inconvenience. Dislocation outwards is also rare, the head of the bone being- displaced to the outer side of the external condyle, where it can easily be felt, causing con- siderable impairment of the natural movements. Reduction is accomplished without diffi- culty. Occasionally a rare form of dislocation is met with in which the ulna passes backwards and the radius forwards, resulting in great deformity. A very common accident in children consists of a subluxa- tion of the head of the radius downwards within the orbicular ligament, so that a portion of it slips up and becomes nipped between the head and capitellum. It results from forcible traction of the hand, and is a common nursery accident, popularly known as pulled elbow. The limb becomes fixed in a position of semi- flexion, and the child cries out with the pain; it is readily treated by completely flexing the iimb, and subsequently extending it, and leaves no bad results. lit must not be forgotten that we have here merely described the pure dislocations. In actual practice complications of a serious Fig. 201. — Dislocation of the Radius Backwards. (Diagram- matic.) PLATE XXtfll. Dislocation of Radius forwards, and Fracture of Upper Third of Ulna. To face /. 558.] INJURIES OF JOINTS— DISLOCATIONS 559 nature are frequently present in the shape of fracture of one or both condyles, which lead to much difficulty in diagnosis. These fracture-dislocations give rise to so much haemorrhage that it is frequently impossible to come to a correct conclusion as to the nature of the case without the assistance of the Rontgen rays. It is doubtful, however, whether even an accurate knowlege of the nature and extent of the lesion will enable us to improve on the results hitherto gained, apart from operation. So much callus is formed, and fibrous adhesions of such strength are developed, that considerable impairment of function is almost certain to ensue. Probably the best line of practice is to keep the elbow at rest on a rectangular splint for a few days, so as to allow the immediate effects of the accident to pass off, and then to make an aseptic incision, dealing with the condition of affairs in the way best suited to the requirements of the particular case. Dislocation of the Wrist is a very uncommon accident, and may occur forivards or backwards. The lower ends of the radius and ulna become prominent under the skin, and especially the styloid processes. By this means it is easily distinguished from a fracture of the lower ends of the bones. Occasionally the radius, carrying with it the hand, is dislocated from the lower end of the ulna, as a result of forcible pronation. This is usually described as a backivavd dislocation of the ulna, and is easily reduced by manipulation. Dislocations of various Carpal Bones have been described, but the only one which is at all common is a displacement of the os magnum backwards. It forms a rounded prominence under the skin in the usual situation of the bone, which becomes more prominent on flexion, and may disappear on extension. As a rule, it is readily reduced, but is very likely to recur. Dislocations of the Metacarpal Bones and Phalanges are not unfrequent, but need no special mention, except in the case of Dislocation Backwards of the First Phalanx of the Thumb. The chief interest in this case lies in the difficulty experienced in re- duction, which was erroneously attributed to the head slipping between the two portions of the flexor brevis pollicis and being grasped by them, as a button in a buttonhole. It has now been shown that there are two much more important factors, viz., the tension of the long flexor tendon, which hitches round the neck (Fig. 202), and the arrangement of the glenoid ligament. This structure passes between the two heads of insertion of the short flexor, and is thus incorporated between the two sesa- moid bones ; it consists of fibro-cartilage, and, whilst firmly attached to the base of the phalanx, is but loosely connected with the head of the metacarpal bone, so that it accompanies the phalanx in its dislocation. It thus comes to be situated imme- 560 A MANUAL OF SURGERY diately behind the head of the metacarpal, and opposes any attempts at reduction. Treatment. — -Traction and manipulation are always attempted in the first instance. The thumb is grasped by a suitable apparatus and hyper-extended to a right angle, thus making the head of the metacarpal project still further through the muscular interspace, and, as it were, enlarging the buttonhole. Still maintaining the traction, the thumb is rapidly flexed into the palm, the metacarpal bone being at the same time pressed inwards. Should this fail, as it often will, a purified tenotome should be inserted in the middle line of the thumb behind, im- mediately above the base of the phalanx, and should be pushed on till it reaches and divides the glenoid fibro- cartilage between the sesa- moid bones ; this little manoeuvre will at once render replacement simple. Dislocation of the Hip, though not very common, is a condition of extreme gravity. The depth of the socket in which the femur rests, and the strength of the muscles and ligaments surrounding the articulation, explain the comparative in- Fig. 202. -Dislocation of Thumb, f req uency of the accident. showing Head of the Metacarpal t h . j , , , Bone protruding Forwards between ^ 1S never produced by the Heads of the Short Flexor direct violence, but always Muscle. (Pick.) results from a force applied to the feet or knees, or, if the legs be fixed, to the back. It is rarely met with except in young people or adults, since after the age of forty-five fractures of the neck of the bone are much more likely to occur. In considering these dislocations, the relative strength or weak- ness of the different parts of the capsule and its surrounding structures must be remembered. Thus, the weakest part of the capsule is placed below and behind, and the fibres here are easily lacerated : indeed, it is through a rent in this part of the capsule that the b^ad of the bone most frequently escapes. In front, the ilio-femoral or Y-shaped ligament of Bigelow, extending from the anterior inferior iliac spine to the anterior intertrochanteric line, is a structure of much strength, on the integrity of which depends the fact whether the displaced head of the bone shall occupy some definite position or be freely moveable. Bigelow, to whom we INJURIES OF JOINTS— DISLOCATIONS 561 owe so much in the elucidation of the mechanism of these dis- locations, has divided them into two classes — the regular and the irregular — according to whether this ligament is intact or com- pletely lacerated. Posteriorly, the plicated tendon of the obturator internus is the most important structure, and the position and level of the bone on the dorsum ilii depends in some measure on whether it remains intact or is ruptured. It must also be remem- bered that the ligamentum teres is relaxed when the thigh is forcibly abducted, and is made tense by adduction. Four chief varieties of dislocation are described, in two of which the head of the bone is displaced posteriorly, and in two anteriorly. The two former are known as the Dorsal and the Sciatic varieties, although Dorsal below the tendon, as originally suggested by Sir Astley Cooper, is the better appellation for the latter variety. The two anterior dislocations are known as the Obturator or Thyroid, and the Pubic; in the former the head of the bone is located in the obturator notch, and in the latter upon the pubic ramus. The relative frequency of these disloca- tions is as follows : About 50 to 55 per cent, of the cases are of the dorsal type, 20 to 25 per cent, sciatic, 10 to 15 per cent, obturator, and 5 to 10 per cent, pubic. In addition to these four varieties, many other slight modifications have been described, which it will be unnecessary to further particularize. Mechanism. — Some surgeons strongly maintain the opinion that the limb is always in a position of abduction at the moment of dislocation, the head of the bone escaping from the capsule through a rent in the lower and back part of the ligament, and thus being primarily displaced downwards. The type of accident responsible for this is a fall with the legs widely separated, or when the limbs are drawn forcibly apart, as, for instance, when one leg is placed on a boat just moving away from a pier on which the other is fixed. The direction of the violence, or the subsequent manipulations performed by willing but ignorant friends, or the voluntary movements of the individual, determine what form of dislocation is to be subsequently produced. If the limb is externally rotated and extended, the head travels forwards, and either the pubic or obturator variety results. If, however, the leg is inverted and flexed, the head of the bone passes back- wards, and either the dorsal or sciatic form is produced. Again, in the posterior dislocations, if the obturator internus tendon remains intact, it may hitch across the front of the neck, and prevent any further upward displacement of the bone, thus giving rise to the so-called sciatic variety ; but if the tendon is ruptured, or if the head of the bone slips in front of it, there is no obstacle to its upward displacement on the dorsum ilii. Bigelow, however, and with him many other surgeons, main- tain that dislocation of the hip does not only occur with the limb in a position of abduction. Under certain circumstances, it may 36 562 A MANUAL OF SURGERY also result when the limb is in a position of adduction, a direct dorsal dislocation being thus produced, the head of the bone escaping from the capsule above the tendon of the obturator internus ; such an accident is sometimes, but not always, associated with fracture of the posterior lip of the acetabulum. The type of violence leading to this occurrence is when a heavy weight falls on the back of a person whilst kneeling, or when, his knee being fixed, the body is thrust forwards, so that the limb is forcibly inverted. If, however, the thigh is in a position of extreme flexion, the head may be displaced below the tendon of the obturator internus, and the sciatic variety will then result. i. Dorsal Dislocation (Fig. 203). — The head of the bone in this form is found lying on the dorsum ilii, a variable distance above and behind the aceta- bulum, and always above the obturator internus tendon. It may be detected on manipulation of the limb, although in muscular subjects this is difficult. The ligamentum teres is necessarily ruptured, as also the capsule, the rent being situated either below or above the obturator tendon according to whether the dislocation is due to forcible abduc- tion or adduction. The small external rotator muscles are usually lacerated, and perhaps even the glutei and the pectineus. The ilio-femoral ligament usually remains intact. The great sciatic nerve is sometimes compressed or contused. The trochanter is raised above Nelaton's line (p. 473), and ap- proximated to the anterior superior spine ; the ilio-tibial band of fascia is therefore relaxed, and there is consider- able shortening of the limb, amounting often to 2 or 3 inches. The leg is in a position of flexion, adduction, and in- version, so that the axis of the femur crosses the lower third of the sound thigh. The knee is semi-flexed, and the ball of the great toe rests against the opposite instep ; the heel is somewhat raised. A marked hollow is felt in the upper part of Scarpa's triangle, and the main vessels of the limb appear to be unsup- ported. The Diagnosis should be easy, the only difficulty being experi- enced in distinguishing it from an impacted extra-capsular Fig. 203. — Dorsal Dislo CATION OF THE HlP fTlLLMANNS.) INJURIES OF JOINTS— DISLOCATIONS 563 fracture. The character of the accident, the presence of adduction and inversion, the increased breadth of the trochanter in the case of fracture, and the abnormally placed head of the bone in dislocation, are the points to which attention must be directed. 2. Sciatic Dislocation, or dorsal below the tendon, is one in which the head of the bone is prevented from travelling upwards to the dorsum ilii by the integrity of the obturator internus tendon. It may occur either from forced abduction of the limb, or from extreme flexion in the adducted position. The lesions of muscles and ligaments are practically the same as for the dorsal variety. The ilio-femoral ligament is uninjured. The Signs resemble those of a dorsal dislocation, but are less marked. There is less shortening, often not more than ^ to 1 inch ; the limb is flexed, adducted, and inverted, but the axis of the femur is directed across the opposite knee, and the great toe rests against the ball of the great toe of the opposite side. The head of the bone is often much less distinct, owing to the greater thick- ness of the glutei muscles at that level. Treatment of the Two Backward Dislocations is effected in much the same way, whether the dorsal or sciatic variety is present. The most usual method is that of mani- pulation and rotation, so accurately worked out by Bigelow. The patient is anaesthe- tized, preferably on a mattress placed on the floor. The leg is first flexed on the thigh, and the thigh on the abdomen, the position of adduction being still maintained, so that the knee extends beyond the middle line of the body (Fig. 204). This position is maintained for some moments, and then the limb is freely circumducted outwards, and brought rapidly down into a position of extension parallel with the other. By this manoeuvre the tense structures in front of the joint are relaxed, and then the head of the bone is made to retrace its course towards the rent in the capsule, and finally directed upwards into the acetabular cavity. These movements are tersely summarized in Bigelow's words — 1 Lift up, bend out, roll out.'' If this plan does not succeed, the following method of traction may be employed. The patient, lying on his back, is firmly fixed by a bandage or towel passed over the pelvis and secured to two or three hooks or staples driven into the floor. The surgeon stands over the patient, whose thigh is flexed to a right angle on the abdomen, as also the knee upon the thigh. The surgeon's arms are passed under the knee sufficiently far to enable him to grasp his own elbows, and the front of the leg is steadied against 36—2 Fig. 204. — Reduction of Dorsal Dislocation of Hip. (Bryant.) 564 A MANUAL OF SURGERY the operator's perineum. Direct and forcible traction upwards can now be made, and this is often sufficient in itself to lift the head of the bone into the acetabulum. If this is unsuccessful, the move- ments described above can be energetically repeated in this posi- tion. The above plans, combined with the use of an anaesthetic, rarely fail in reducing a backward dislocation of the hip, and hence extension by means of pulleys is rarely required. If, however, it is needed, traction should always be made in the direction of the displaced limb, i.e., across the other thigh, counter-extension being obtained by a jack-towel passed between the injured thigh and Fig. 205.— Dislocation of the Hip: Obturator Variety. (Tillmanns.) Fig. 206. — Dislocation of the Hip Forwards: Pubic Variety. (Tillmanns ) the perineum, and fixed to a staple in the floor, close to the head of the patient, and on the side of the dislocation. When sufficient force has been applied, the surgeon rotates the limb outwards so as to allow the head of the bone to once more slip into its socket. 3. Thyroid or Obturator Dislocation (Fig. 205). — The head of the bone in this case passes downwards through a rent in the lower part of the capsule, and its position is subsequently but little altered, a slight forward and upward movement being alone superadded. The ilio-femoral ligament is untorn, but the pectineus and adductors are very tense, or may even be lacerated ; the INJURIES OF JOINTS— DISLOCATIONS 565 ligamentum teres is, of course, ruptured. The head lies on the obturator externus muscle, and can be detected in the perineum. The trochanter is less prominent than usual, and, indeed, its normal position may be represented by a depression. The limb is slightly abducted and everted, as well as lengthened, perhaps to the extent of 2 inches, though this is more apparent than real. It is also flexed, owing to the tension of the ilio-psoas muscle, and advanced before the other, with the toes pointing outwards. The adductor longus tendon stands out prominently, and much pain may be experienced from pressure on the obturator nerve. If the patient stands, the body is bent forwards, whilst it is interesting to note that if the dislocation remains unreduced the patient may be able to walk without much pain or inconvenience, though in a more or less stooping position. 4. Pubic Dislocation (Fig. 206). — In this variety the head of the bone lies on the horizontal ramus of the pubes, just internal to the anterior inferior spinous process of the ilium, where it can be felt roll- ing under the finger on any move- ment of the limb. The vessels are pushed inwards, and considerable pain may be felt down the limb from pressure on the anterior crural nerve. The ilio-femoral ligament is untorn, whilst the ligamentum teres and capsular ligament are ruptured ; the small external rotator muscles, with the exception of the obturator internus, are usually torn. There is marked flattening of the hip, the trochanter being approximated to the middle line and raised. The iimb is shortened to the extent of 1 inch, and there is considerable abduction and eversion, so that the inner aspect of the limb looks forwards. The thigh is slightly flexed to relax the ilio-psoas muscle. Treatment of the thyroid and pubic dislocations is undertaken along similar lines as for the posterior dislocations. The patient is anaesthetized ; the knee is flexed, as also the thigh upon the abdomen, but in a position of abduction ; circumduction inwards follows (Fig. 207), and on extension of the limb the head again enters the acetabulum. The thyroid variety may sometimes be reduced by upward and outward traction when the limb has been flexed to a right angle in the abducted position, the unbooted foot being placed against the pelvis to steady it. If extension by pulleys is required in the thyroid dislocation, it is made transversely outwards across the upper part of the thigh, counter-extension being obtained by means of a band passed round Fig. 207. — -Reduction of An- terior Dislocations of the hip. (Bryant.) 5 66 A MANUAL OF SURGERY the abdomen. The limb, at first in a position of abduction, is subsequently adducted forcibly by drawing the ankle inwards, the band by means of which extension is being made acting as a fulcrum to lever the head of the bone into the acetabulum. In the pubic variety traction is made downwards, outwards, and backwards, and the head of the bone drawn into its socket by a towel passed transversely across the limb. After reduction of any form of dislocation of the hip, the patient should be kept in bed with the legs tied together for about a fortnight, and then passive movement may be commenced, but with considerable caution ; voluntary movements should not be undertaken for another week or two. Should the dislocation recur, it may be due to fracture of the posterior lip of the acetabulum, or to some involuntary move- ments of the patient, or perhaps to the fact that the displacement has not been fully reduced. Under such circumstances further attempts at replacement should be undertaken, and the limb sub- sequently kept immobilized for a longer period than usual. Irregular dislocations of the hip occur when the Y-shaped ligament is completely torn through, so that the head of the bone is not restricted, but can be moved round the acetabular cavity. Reduction is usually easy. Dislocation of the Patella may occur outwards, inwards, or edgeways. A dislocation upwards resulting from rupture of the ligamentum patellae is sometimes described, but it is scarcely to be included in the same category as the others. The displacement may be complete or incomplete ; in the former the capsule is always lacerated ; in the latter, not necessarily so. The outward variety is much the commonest on account of the obliquity of the limb, and may result from muscular action, especially in people suffering from genu valgum ; it also arises from direct violence. In either case it occurs most frequently when the limb is extended, since during flexion the bone is firmly lodged in the intercondyloid notch. When completely displaced, it lies upon the outer surface of the condyle, with its inner margin projecting forwards. In this situation it is easily felt, whilst the knee appears flattened and broader than usual, the intercondyloid notch being plainly distinguishable in the posi- tion usually occupied by the patella. It is not unfrequently, however, incomplete, and then the inner half of the articular surface of the patella lies in contact with the cartilaginous surface of the outer condyle, with its outer border projecting forwards. Reduction may take place spontaneously, but is usually effected by manipulation. The thigh is flexed on the abdomen, and the knee extended, so as to relax the quadriceps, and then a little pressure on its outer margin causes the bone to slip back into place. In the incomplete form where one of the borders of the INJURIES OF JOINTS— DISLOCATIONS 567 bone is lodged in the intercondyloid notch, reduction is sometimes very difficult, and to effect it an open operation may be required. The inward dislocation is rare, being always due to direct violence. In characters and treatment it is the exact converse of those met with when the bone is displaced outwards. A dislocation edgeways, or Vertical Kotation of the patella, is an interesting condition in which the bone is said to be twisted vertically upon its own axis, and even to have been turned com- pletely round. Incomplete rotation is practically identical with that just described as an incomplete lateral dislocation, whilst the complete rotation of the patella must indeed be a rare accident. Dislocations of the Knee may occur laterally, as also forwards or backwards. When due to disease of the joint, the backward dis- location is commonest ; but when arising from traumatic causes, the lateral is the most frequent. The lateral displacements are rarely complete, and are usually associated with a certain amount of rotation ; the leg is partially flexed. Reduction is effected without difficulty. Dislocation of the tibia forwards is more common than dis- placement backwards. It is frequently complete, the lower end of the femur projecting into the popliteal space, and compressing the vessels. The upper end of the tibia, carrying with it the patella, lies in front, forming a well-marked swelling with a hollow above it. There is usually considerable shortening of the limb if the articular surfaces overlap. Dislocation of the tibia backwards is a much rarer accident, and is more often incomplete than the former. The signs are exceed- ingly characteristic, the pressure effects upon the popliteal vessels and nerves being less pronounced. Reduction of either of these conditions is easily accomplished by traction on the limb, whilst the thigh is flexed, combined with manipulation in order to guide the head of the tibia into its normal position. The limb must subsequently be kept at rest in splints for two or three weeks. Displacement of a Semilunar Cartilage (Syn. : Subluxation of the Knee, Internal Derangement of the Knee-joint) is a condition fre- quently met with, resulting from sprains and strains of the joint. In any rotary movement of the knee, which, however, can only be undertaken when the limb is flexed, the pressure of the condyles always tends to modify the position of the cartilages ; moreover, with the limb in a state of flexion, they are relaxed and more freely moveable on the upper surface of the tibia than in exten- sion. Any sudden strain or wrench, e.g., turning quickly round in such games as tennis, or slipping off the kerbstone with the knee bent, may lead to this accident. The internal cartilage is much more frequently affected than the external, and the character and 5 6S A MANUAL OF SURGERY extent of the lesion varies much in different cases. Not unfre- quently its anterior tibial attachment is torn through, thereby per- mitting considerable lateral mobility. Its peripheral connections with the capsule and internal lateral ligament may also be ruptured, whilst sometimes a portion is more or less detached from its free border, and in other cases the cartilage has been broken across a little behind its centre. It is obvious that when once its connec- tions have been loosened it can be displaced readily, and may pass into the intercondyloid notch, or may slip out from between the tibia and femur, or may even be doubled over. After displacement it becomes inflamed and swollen, and unless properly treated this will be likely to predispose to a renewal of the displace- ment. The Symptoms produced by this accident are a sudden sicken- ing pain of much severity, located in the knee, which becomes partially locked in a position of flexion, with inability to extend. The patient may be able to ' wriggle ' his joint free, or the limb may remain stiff for some hours, or even a day or two, when movement suddenly returns more or less spontaneously, a snap being at the same time felt within the joint. An attack of sub- acute synovitis usually follows. In other cases the cartilage remains out of place, until reduced by the surgeon, with or with- out an anaesthetic. If the case is not carefully treated, the dis- placement is liable to recur, the cartilage constantly slipping in and out, and getting nipped between the bones ; as time goes on, this becomes more and more easy, owing to the ligaments of the joint being relaxed from the recurrent attacks of synovitis. In fact, the limb may pass into such a state of chronic weakness as to seriously interfere with the patient's comfort. No physical changes can as a rule be detected between the attacks, but there is usually a spot of localized pain in the front of the joint, cor- responding to the upper surface of the tibia ; possibly there may be some amount of lateral mobility of the leg, and movement of the cartilage may ba detected on flexing and extending the knee. The Treatment in the early stages consists in replacement of the cartilage by manipulation. The limb is fully flexed and then suddenly extended, pressure being applied at the same time in the neighbourhood of the displaced cartilage, which often returns into position with a distinct snap. The limb is subsequently kept at rest on a back-splint, and cooling lotions are applied until the in- flammation has subsided ; it is then further immobilized for some weeks in plaster of Paris or water-glass, so as to allow the lacerated ligaments to reunite and consolidate. At the expiration of six or eight weeks after the accident an elastic knee-cap is applied, and the patient again allowed to move the joint. When the cartilage has become loose and is constantly slipping out of place, immobilization of the limb, with pressure over the painful spot by an elastic knee-clip, as recommended by Mr. INJURIES OF JOINTS— DISLOCATIONS 569 Howard Marsh, may be useful. Should this not prove satis- factory, operative proceedings must be undertaken. The knee-joint is opened by an incision on the appropriate side of the patella, more or less transverse in direction, and the con- dition of the cartilage ascertained. If of normal shape and merely loose and moveable, it may be readily stitched to the periosteum over the head of the tibia, so as to keep it from again slipping between the bones ; this is perhaps best accomplished by splitting the cartilage diagonally into two portions, and securing each of these by two or three catgut stitches. If, however, it is doubled on itself, or deformed, or if fixation seems impracticable, it may be removed ; it is astonishing how well patients get on after such an operation. The greatest care must be taken to maintain asepsis, and no strong or irritating antiseptic should be allowed access to the joint cavity, which is closed by a series of buried sutures, dealing in order with the synovial membrane, the capsule, the superjacent tendinous tissues, and, finally, the skin. It is advisable to drain the joint for twenty-four hours, and, as an additional precaution against infection, it may be well to immunize the patient by preparatory injections of antistreptococcic serum. Dislocations of the Ankle-joint may occur in the following directions : outwards, inwards, backwards, forivards, and upwards, this being the order of their frequency. Owing to the fact that the astragalus is wedged like a block into the mortice formed by the lower ends of the tibia and fibula, it is obvious that fractures of these bones are frequently met with as complications. The lateral dislocations are in reality fracture-dislocations, and have been already described in the chapter on fractures (p. 489). Although the upper articular surface of the astragalus is broader in front than behind, dislocation of the foot backwards is a more common accident than displacement forwards. It results from falls on the feet while running or jumping, or by sudden violence applied to the limb when the foot is fixed. Usually both malleoli are fractured, and the articular surface of the astragalus is thrown behind the lower end of the tibia. The heel projects unduly backwards and the lower end of the tibia usually rests upon the neck of the astragalus, the scaphoid, or even the cuneiform bones. Dislocation forwards is very uncommon, and may occur with- out any associated fracture of the bones of the leg. The foot is apparently lengthened, and the tibia rests upon the posterior part of the upper surface of the os calcis, behind the astragalus. The prominence of the heel and of the tendo Achillis is lost, and the normal depression in front of the latter structure is occupied by the lower ends of the bones of the leg. The treatment of antero-posterior dislocations consists in reduc- tion by traction. The leg is flexed upon the thigh, so as to relax the tendo Achdlis, or, if necessary, this structure is divided. The 57c A MANUAL OF SURGERY ankle is commanded by a pair of Cline's side-splints, care being taken to ascertain that the foot is at right angles to the leg, and that the articular surfaces of the astragalus and tibia are exactly in apposition, thus preventing any displacement of the heel back- wards or forwards. A Roughton's splint — i.e., an external splint with a sole-piece — is sometimes useful. A dislocation upwards has been described in which the astra- galus, together with the foot, is carried up between the tibia and fibula. To allow of such, the inferior tibio-fibular ligament and the lower end of the interosseous ligament must have been ruptured. Impracticable as such an accident appears, competent Fig 20S. — Dislocation of the Astragalus Forwards. observers maintain that they have met with it. The displacement js very marked, and the character of the lesion very evident. Dislocations of the Astragalus alone are by no means common, although their distinguishing features are well recognised. They consist in a partial or complete detachment of the bone from all its normal connections, both to the bones of the leg and of the foot, and its displacement from under the tibio-fibular arch. It may travel backwards or forwards with or without lateral rotation. Dislocation forwards (Fig. 208) is much the more common variety, although it is usually associated with partial rotation, the displacement occurring more frequently outwards than inwards. When complete, the bone is entirely detached from its connec- tions with the os calcis, scaphoid, and bones of the leg, and lies upon the upper surface of the scaphoid and cuneiform bones, the INJURIES OF JOINTS—DISLOCATIONS 571 skin of the dorsum of the foot being tightly stretched over it, or even torn. The limb is shortened, and the malleoli are approxi- mated to the sole, the lower end of the tibia resting on the upper surface of the os calcis. In the incomplete variety, the head of the astragalus impinges either upon the scaphoid on the inner side, or the cuboid on the outer, whilst the lower end of the tibia rests on the posterior half of the articular surface of the astragalus. Dislocation backwards is almost always complete, and may or may not be associated with rotation of the bone, which can easily be felt between the tendo Achillis and the malleoli. Treatment. — Reduction is only possible in the incomplete forms of dislocation. The patient is anaesthetized, the knee flexed to relax the muscles or the tendo Achillis divided, and traction upon the foot established, so as to enable the surgeon to apply direct pressure upon the displaced bone in a suitable direction. In the complete variety reduction is impracticable, owing to the fact that the os calcis is drawn up into contact with the malleolar arch. In such cases manipulation is useless, and excision of the bone is necessary. Comparatively little impairment in the function of the foot results from this operation. Subastragaloid Dislocation. — By this term is meant a displace- ment of all the bones of the foot from below the astragalus, which retains its normal position between the malleoli. The interosseous and other ligaments passing from the malleoli and astragalus to the other tarsal bones are necessarily ruptured. The cause of this, as of other dislocations in the neighbourhood, is some violent strain or wrench of the foot. Displacement of the foot may occur either forwards or back- wards, but in the great majority of cases it is either backwards and inwards or backwards and outwards. The luxation is rarely complete as regards the calcaneo-astragaloid joint, but the articular surfaces of the head of the astragalus and scaphoid are completely separated, the former structure lying on the dorsal surface of the latter bone. The foot is greatly deformed, the anterior portion being shortened, the heel projecting, and the toes pointing downwards. The head of the astragalus is very evident, forming a rounded globular swelling under the tense skin. In a compound dislocation of this nature which we recently examined, post mortem, the inner edge of the under surface of the astragalus had burst through the skin ; the vessels and nerves were torn or stretched, and even when the wound in the skin had been enlarged, reduction was impossible owing to the tendons which had become caught around the neck of the astragalus. In such a case removal of the astragalus would have been the only practicable treatment. In the inward displacements, the foot is somewhat inverted, so that the outer malleolus is unduly prominent, and the inner 572 A MANUAL OF SURGERY malleolus is lost in a deep depression caused by the lateral dis- placement of the os calcis ; the foot is thus in a position somewhat simulating talipes equino-varus. In the outward dislocations, the foot is everted, the inner malleolus prominent, and the outer buried, a position of talipes equino-valgus being thus assumed. In both forms the tendo Achillis is curved, with its concavity towards the displacement. Treatment consists in reduction by manipulation, which is sometimes readily accomplished, but may be a matter of the greatest difficulty, probably from the tibial tendons becoming bitched around the neck of the astragalus. Section of the tendo Achillis is occasionally needed. CHAPTER XX. DISEASES OF JOINTS. Acute Synovitis. By Synovitis is meant an inflammation limited almost entirely to the synovial membrane, the ligaments and other structures of the joint being usually but little affected. The Causes are local and general. Local conditions include cold and injury ; general or constitutional comprise rheumatism, gout, syphilis, pyaemia, and gonorrhoea. Pathological Anatomy. — Acute synovitis results in hyperaemiaof the synovial membrane, and exudation of plasma and leucocytes, firstly into the substance of the membrane, causing it to be thickened and spongy, and subsequently into the joint ; the endothelium also proliferates, and is shed. In the early stages the effusion consists of synovia, diluted with blood plasma, and often discoloured with blood in traumatic cases, and hence on removal is spontaneously coagulable ; after a time the plasma may coagulate, depositing lymph upon the articular surface whilst serum remains. The lymph thus deposited may either be removed by a natural process of absorption when the inflammation comes to an end, or it may organize, so as to form adhesions. In the later stages the synovial membrane becomes somewhat thickened, and the ligaments possibly a little infiltrated and relaxed. The Clinical Signs of acute synovitis consist in the joint be- coming painful and distended, whilst if the articulation is super- ficial, as in the knee, a sense of heat may be imparted to the hand, and the surface may even be red and hyperaemic. The limb is maintained by muscular spasm in that position which gives the most ease, viz., that in which its capacity is the greatest, and this is usually one of slight flexion, but if the condition is neglected, the flexion may increase considerably, the muscles undergoing tonic contraction, and the limb remaining more or less fixed in an undesirable position. The muscles governing the movements of the joint occasionally undergo rapid atrophy, probably resulting from a reflex disturbance of their trophic centres in the cord. 574 A MANUAL OF SURGERY Evidence of Effusion into Various Joints. — Shoulder : The curva- ture of the shoulder is increased, and the deltoid expanded by a fluid swelling beneath it, which is especially noticeable at its anterior border along the bicipital groove, and sometimes pos- teriorly ; in the axilla a painful intumescence may also be felt. These symptoms may be somewhat simulated by inflammation of the multilocular subdeltoid bursa, but the latter condition is recognised by the absence of any axillary swelling, by its not encroaching on the anterior and posterior borders of the deltoid, and by the fact that, although when the patient voluntarily moves his arm pain is produced, yet when the surgeon gently manipu- lates it, so as to press the head of the bone against the glenoid cavity, there may be none. Elbow : The hollows on either side of the olecranon and tendon of the triceps are replaced by soft fluid swellings, the outer of which also extends down to, and masks, the head of the radius ; there is usually a little general puffiness in front of the joint. It is readily distinguished from inflammation of the olecranon bursa by the fact that in the latter condition there is a central fluid prominence over the bone, whilst in the former the swellings are placed on either side of and above the bony projection. Wrist : There is a general fulness both on the anterior and posterior aspects of the joint, whilst fluctuation may be detected beneath the dorsal tendons, which are slightly separated and displaced. It is distinguished from synovitis of the superjacent tendon sheaths by the fact of its strict limitation to the neighbourhood of the joint, and the absence of the superficial crepitus, so characteristic of the latter condition. Effusion into the Hip-joint cannot be easily detected by digital examination. There may be a little fulness and tenderness in the gluteal region, or in the upper and outer part of Scarpa's triangle. The most characteristic feature, however, is the position of flexion, abduc- tion, and eversion taken by the limb, whilst limitation of move- ment is equally marked. The Knee, when distended with fluid, presents a rounded outline, in which all the normal hollows, especially those on either side of the patella and ligamentum patellae, have disappeared. There is also a swelling correspond- ing to the subcrureal pouch, more marked on the inner than the outer side, and extending for 3 or 4 inches above the patella. Fluctuation can be readily detected when one hand is placed above the patella, and the fingers of the other hand compress the tissues on either side of the ligamentum patellae below, or by alternate pressure on either side of the rectus tendon. When the effusion is large in amount, the patella is felt to float, and on pressing it sharply backwards can be made to tap against the intercondyloid notch of the femur (patella tap). Enlargement of the bursa patellae is easily distinguished from it by the swelling in the former case being central and in front of the patella, so that its outline is obscured. Ankle : The hollows between the tendo DISEASES OF JOINTS 575 Achillis and the malleoli are replaced by fluctuating swellings whilst the dorsal tendons are displaced forwards, and a fluid swelling appears in front of each malleolus. Enlargement of the bursa beneath the tendo Achillis is so obviously confined to the back of the joint that it should never be mistaken for true synovitis of the ankle. When the acute stage has passed, the joint is usually left in a somewhat weak and relaxed condition, with a little passive effusion, or perhaps some adhesions. The adhesions which follow acute synovitis are usually slight in character, if the case has been properly treated ; they result from the union of patches of lymph on opposing surfaces of synovial membrane or bone, which become organized into loose fibro-cicatricial tissue, containing a few delicate bloodvessels, and covered by endothelium extending over them from the adjacent serous membrane. The charac- teristic signs of such a condition are painful limitation of move- ment in some particular direction, and possibly a little soft crepitus. The Treatment of acute synovitis consists in so immobilizing the joint as to give the patient the greatest amount of ease, whilst, should ankylosis result, the limb is left in as favourable a position as possible for subsequent utility. Thus, the shoulder should be bandaged to the side and the hand kept in a sling ; the elbow is placed on an internal angular splint, and flexed to a little more than a right angle, whilst the hand is midway between pronation and supination ; for the wrist all that is needed is to apply a palmar splint to the forearm ; the hip is immobilized by the application either of a Thomas's splint or of a Liston's long splint, or by placing the limb between sandbags and adjusting an extension apparatus to the foot ; the knee is put on a back-splint, perhaps slightly flexed ; whilst the ankle is best kept at rest by applying what is known as a Roughton's splint, i.e., an external splint with a foot-piece. Necessarily, in all severe cases of acute synovitis the patient should be confined to bed and the limb elevated. If the case has been neglected and the limb has assumed a vicious position, the patient should be anaesthetized and the malposition corrected ; or gradual extension made by means of a weight and pulley, until the correct position is attained. In the early stages cold should be applied to the joint by means of evaporating lotion, an icebag or Leiter's tubes, but this is not advisable in old people. In the later stages fomenta- tions give greater relief, whilst the application of a few leeches may also be beneficial. When the distension is considerable, removal of some of the fluid by a carefully purified aspirator, or trocar and cannula, may diminish pain and hasten recovery. In the subacute stage, when the joint is weak and relaxed, massage or friction with stimulating liniments should be em- ployed, whilst in the more chronic forms firm pressure, and pre- 576 A MANUAL OF SURGERY ferably by means of a Martin's bandage, is most useful as an additional measure. If adhesions are present, they should be carefully broken down under chloroform ; the limb is subsequently kept at rest for a few days upon a splint, whilst passive movements and massage are afterwards adopted. Chronic Synovitis. This affection follows an acute attack, or may be lighted up by some injury or condition insufficient to determine a more violent form of inflammation. The synovial membrane becomes thick and infiltrated, whilst the effusion is sometimes relatively less than in the acute form, sometimes excessive, then con- stituting the condition de- scribed as chronic serous synovitis (Fig. 209), a phenomenon often seen affecting the knees after rising from a prolonged stay in bed. The pain is usually not severe, being replaced by a sense of uselessness and weak- ness. It is interesting to note that, in cases where the effu- sion is well marked, the bursae communicating with the joint frequently become distended ; they are prevented from par- ticipating in the acute forms of inflammation by the fact that the apertures of com- munication with the interior of the joint are narrow and slit like, and thus readily become occluded by the swelling of the membrane. Crepitus is sometimes met with in chronic synovitis, possibly from a roughening of the articular surfaces on which lymph has been deposited, or between which fibrous adhesions have formed. Occasionally the synovial fringes become hypertrophied, giving rise to a condition similar to that described under osteo-arthritis (p. 598). The overgrown villi usually spring from the reflections of the synovial membrane close to the bone, and may be loaded with fat, constituting the condition known as ' Lipoma arbo- Fig. 209. — Chronic Serous Synovitis of Knee, with Distension of the subcrureal pouch. (from col- LEGE of Surgeons' Museum.) DISEASES OF JOINTS 577 rescens.' In the knee-joint the fringes may be felt rolling under the fingers, and painful symptoms may be caused by the loose ends being caught and nipped between the bones. Treatment consists in fixing the joint in a suitable position, and applying counter-irritation and pressure ; blisters are especially useful in this affection. At a somewhat later stage elastic pressure by a Martin's bandage may be employed, together with friction with stimulating liniments, or even hot-air baths. Re- moval of some of the fluid by aspiration and subsequent com- pression may also do good ; but if the affection resists such treat- ment, the best procedure consists in opening the joint, washing it Fig 210. — Baker's Cysts from Back of Knee. (Howard Marsh ) out with normal saline solution or with a solution of corrosive sublimate (i in 4,000), and draining it for a few days. Should enlarged villi be present and give rise to trouble, the joint should be opened, and if they are limited in their distribution they may be clipped away, or the synovial membrane from which they grow dissected out. When very extensive, so that removal would involve total excision of the synovial membrane and con- sequent stiffness, it may be wise to wash out and drain, in the hope that they may become fixed, before undertaking complete extirpation of the membrane. Hydrarthrosis (Hydrops Articuli) is the term applied to any condition of a chronic nature in which the joint is much distended with fluid. It may arise from at least five different affections : (a) Chronic serous synovitis; (b) in osteo-arthritis, a very common cause; (c) in Charcot's disease; (d) in secondary syphilitic synovitis ; and (e) very rarely in tuberculous synovitis. It must 37 578 A MANUAL OF SURGERY be remembered that it is but a symptom, and not a disease sui generis, and treatment necessarily varies with the cause. Baker's Cysts. — This condition, first described by the late Mr. Morrant Baker, consists in a hernial protrusion of the synovial membrane of a joint through an aperture in its fibrous capsule (Fig. 210). It is usually due to some chronic affection of the articulation, especially osteo-arthritis, or tuberculous disease, whereby the intra-articular pressure is increased, and not uncommonly several such sacs are connected with the same joint. They vary much in size, contain synovial fluid, and, though at first communicating with the joint cavity, have a tendency to travel away from it, burrowing along muscular and fascial planes, and coming, perhaps, to the surface some distance from their origin, the aperture of communication with the joint having in some instances been shut off. If causing no troublesome symptoms, there is no necessity to interfere ; but if they become inconvenient or painful, it is easy to dissect them out, closing where necessary by ligature or suture the narrow neck which leads into the joint. Of course, the strictest asepsis must be maintained in all such proceedings, and the causative affection must not be forgotten. Acute Arthritis. By the term Arthritis is meant any inflammation of a joint which involves all the structures of which it is composed, viz., bones, ligaments, cartilages, and synovial membrane. Causation. — Acute arthritis is practically always due to infection of the joint cavity with bacteria, which reach it either from within or without the body, (i.) It may be due to the entrance of cocci through a punctured or valvular wound of the joint, or during operations. It is interesting to note how extremely prone to in- flammation is the synovial membrane when opened, even after the most careful antiseptic precautions. The micro-organism most commonly present is a modification of the Streptococcus pyogenes, known as the Strep, articulorum ; it is pathogenic to mice and rabbits, but not to guinea-pigs, and when injected into a rabbit seems to especially select the joints. Various non-pathogenic organisms have also been found in special cases, (ii.) It may arise in a manner exactly analogous to that in which acute infective osteomyelitis is produced — i.e., the patient is in a low state of health, his natural germicidal powers are diminished, pyogenic organisms are present in the blood-stream, gaining access through some breach of surface, and, finally attacking any weak or damaged tissue, produce therein suppurative inflammation. A slight injury, e.g., a sprain or strain occurring in a weakly child, convalescent from measles or scarlet fever, may result in this affection, (iii.) It may be produced by the lodgment of a pyaemic embolus, and in a similar way it not unfrequently follows as a DISEASES OF JOINTS 579 sequela of fevers, such as enteric or pneumonia, by direct trans- mission of some infective material, (iv.) It is sometimes met with as a result of gonorrhoea, and may then run its course with or without suppuration, (v.) It may be lighted up as a result of the extension of inflammation from the end of a neighbouring bone, or from the bursting of a subcutaneous or bursal abscess into the joint. Acute arthritis of the hip-joint is commonly due to the former of these conditions, being consecutive to an acute infective osteomyelitis of the upper end of the femur, (vi.) It is occasion- ally observed as a result of rheumatism , the inflammation running a very acute course, and leading to disorganization of the joint, though without suppuration. Such attacks are undoubtedly bacterial in origin. Course of the Case. — In the early stages acute arthritis manifests itself as a hyperacute synovitis, combined with severe pain and fever. The pain is often so intense that the patient cannot bear the part to be touched or the bed shaken, and indeed the slightest jar of the limb is so exquisitely painful that the patient may scream with agony. The joint itself is distended with a turbid effusion, which rapidly becomes purulent, and the tissues around are hyperaemic and cedematous. The patient naturally places himself in that position in which the limb obtains the greatest ease, and therefore usually semiflexes the joint and fixes it by muscular contraction. As the disease progresses, pus is formed within the capsule, bursting through it, and either travelling directly to the surface, or burrowing deeply into the substance of the limb ; thus, in the knee an enormous abscess may collect beneath the vasti muscles, stripping them from the bone for a considerable distance. The pain increases whilst the abscesses are forming, and becomes especially distressing at night, the patient being often waked by a painful start just as he has fallen asleep. This condition usually indicates that the articular cartilages are becoming affected, and is explained by the fact that, just as the patient loses conscious- ness, the muscles which fix the joint are relaxed, and allow the inflamed surfaces to slightly shift their position, exciting severe pain and a sudden spasmodic contraction of the muscles. Gradu- ally the deformity becomes more and more obvious, whilst the infiltration and relaxation of the ligaments sometimes allow of abnormal movements, e.g., o f lateral mobility in the knee-joint ; the ends of the bones become carious, and absolute displacement or dislocation may follow. Sinuses may open in all directions, and the patient suffer from recurrent rigors, caused by toxaemia or the onset of pyaemia. The constitutional effects are always severe, consisting of high fever, and rapid exhaustion from the pain, sleeplessness, and absorption of toxins. The terminations of this affection are as follow : {a) Recovery, rarely with a moveable joint, and then only after active inter- 37~ 2 5 8o A MANUAL OF SURGERY i ference ; in most cases ankylosis in a good or bad position, accord- ing to the treatment, is the best result that can be expected. (b) During the acute stage the patient may die of pyaemia, or acute toxaemia and exhaustion, (c) If he survive the acute stage, chronic suppuration may ensue, and symptoms of hectic and amyloid de- generation in the viscera may supervene. In such cases sinuses leading down to carious bones exist, and, unless efficient measures are taken to obtain asepsis, or to remove the diseased structures, perhaps by amputation, the patient is likely to die from exhaustion or chronic sapraemia. Pathological Anatomy. — The synovial mem- brane, at first merely infiltrated and hyper- aemic, soon becomes converted into granula- tion tissue from within outwards, exuding abundant pus. The ligaments in turn are sodden and relaxed by the presence of a plastic exudation between the fibres, render- ing them soft and cedematous, so that the tonic contraction of the muscles easily stretches them and brings about displacement. The articular cartilages are disintegrated and destroyed in various ways, according to the acuteness of the inflammation and the amount of pressure to which they are exposed. In acute cases they early lose their normal bluish- white appearance, and become opaque and slightly yellow. The central parts, which are exposed to pressure between the ends of the bones, soon disappear, whilst the peripheral portions are eroded by the growth of the granulation tissue developing from the synovial membrane. When once the cartilage has been perforated at any one spot, the suppurative inflammation spreads along its under surface, stripping it from the bone, and thus inducing necrosis, as a result of which isolated portions of dead cartilage may be found lying in the joint. In the more chronic forms of the disease, proliferation of the cartilage cells occurs, whereby the capsules become dis- tended, and the matrix encroached upon ; some of these cavities burst into the joint, and leave more or less flask -shaped openings into which pyogenic organisms find their way, thus aggravating the mischief; others nearer the deep aspect of the cartilage become transformed into granulation tissue by vascu- larization from the vessels in the bone. In these ways the carti- lage is destroyed or replaced by granulation tissue, a proceeding Fig. 2ii. — Ends of the Bones after Acute Arthritis of Elbow, show- ing the Carious Surfaces devoid of Cartilage, and the De- velopment of Stalactitiform Osteophytes. (From King's Col- lege Museum.) DISEASES OF JOINTS 581 analogous to ulceration of the softer parts. The intcvavticular cartilages are affected in a very similar manner, and quickly dis- appear. The ends of the bone pass into a condition of acute osteitis resulting in the transformation of the medulla into granulation tissue, absorption of the bony cancelli with or without suppura- tion, and sometimes necrosis of small portions of the cancellous tissue {caries necrotica). The veins within the cancelli become thrombosed, and hence pyaemia may result. The periosteum covering the ends of the bones is also inflamed and hyperaemic, in consequence of which spiculated or stalactitiform osteophytes are produced (Fig. 211). The muscles in the neighbourhood of the joint undergo rapid atrophy and fatty degeneration, probably as a result of some reflex disturbance of the trophic centres. Treatment. — In the early stages the limb must be elevated, abso- lutely immobilized, and put into such a position that, if ankylosis subsequently obtains, it may be of some use to the patient. Fomentations or an icebag may be temporarily applied, but as soon as the symptoms point to suppuration, the joint should be freely opened in one or two places, washed out with some sterile or antiseptic solution, and drainage-tubes inserted, whilst neces- sarily any peri-articular abscesses are dealt with in the same way. Openings should preferably be made on opposite sides of the joint, so as to allow the cavity to be frequently flushed out, or, if considered desirable, for continuous irrigation of the joint with some mild antiseptic (e.g., weak boracic lotion, or sublimate solu- tion, 1 in 8,000), or some bland unirritating fluid, such as sterilized normal saline solution. The fixation of the limb is maintained, and the general health attended to. Irrigation should be continued until all signs of inflammation, pain, heat, and startings of the limb have passed away. Under such a regime it is sometimes possible to obtain a moveable joint, but more frequently ankylosis must be expected. Excision may be required in order to prevent or remedy faulty ankylosis, or to place the limb in a good position ; it is also undertaken in some cases of chronic suppuration, with caries of the ends of the bones and displacement, but, as a rule, not until all acute symptoms have passed away. If the patient is suffering from severe toxaemic or pyaemic symptoms threatening life, amputation may be required, as also for exhaustion from long-standing suppuration and hectic fever. Acute Arthritis of Special Joints. In the Shoulder, infection sometimes occurs through the axilla where the capsule is weak and easily invaded by organisms, as after an axillary cellulitis ; more frequently it follows a pene- trating injury. Severe pain is caused by any movement of the arm affecting the joint, and the pus in the distended synovial S 8 2 A MANUAL OF SURGERY membrane comes to the surface in front of or behind the deltoid, or in the axilla. It may suffice to open the articulation anteriorly and flush it out, but, if possible, a counter-opening should be made behind by cutting down on a pair of dressing forceps pushed back- wards through the capsule. In many instances the patient's condition will not improve until the head of the bone has been excised. The subsequent results as regards movement and power of the arm are, on the whole, very satisfactory. In the Elbow, there are no points requiring special mention as to clinical history or results, although it must be remembered that the superior radio-ulnar articulation is necessarily involved, and hence the power of pronation and supination of the hand is threatened. As to treatment, incisions should be made on either side of the olecranon, the ulnar nerve being avoided. The limb is then placed on a rectangular splint, and with the hand midway between pronation and supination ; of course, the patient is kept in bed, with the arm raised on a pillow. In an adult excision may be undertaken as soon as the acute stage has passed, in order to obtain a moveable elbow ; but in children, where the growth is incomplete, it is better to allow ankylosis to occur, and excise", if need be, at a later date. The Wrist may be infected secondarily to septic conditions following operations on ganglia in the neighbourhood, or through direct injury. The essential treatment consists in free incisions parallel with the tendons, and avoiding the sheaths. Ankylosis usually results, and excision is not resorted to except when the disease has become very chronic, with extensive caries of the carpus. Acute arthritis of the Hip-joint is usually a sequela of acute infective osteomyelitis attacking the upper end of the shaft of the femur, and involving the joint, owing to the epiphyseal car- tilage being intracapsular ; it also results from pyaemia, and rarely from penetrating injuries. The symptoms are similar to those of the first stage of ordinary tuberculous disease (p. 613), but much more acute. There is high fever, together with intense pain, marked flexion and eversion of the limb, early suppuration, and rapid disorganization if not properly treated ; indeed, where nothing is done, and the patient lives long enough, the head of the bone may be entirely absorbed, or is detached, and remains as a sequestrum in the disintegrated articular cavity. As soon as the capsule gives way, the pus may come to the surface in any of the usual localities for hip-joint abscesses. In treating these cases, the joint should be freely laid open in the situation which appears most favourable. The anterior incision is more suitable for the early, and the posterior for the later stages, when the head of the bone is either dislocated, or remains in situ and separated from the shaft. A double opening may sometimes be utilized with advantage. DISEASES OF JOINTS 5S3 The Knee-joint is more frequently involved by this disease than any other, and is usually infected from without. The symptoms are exceedingly typical : the pain is very acute and the joint hot and distended to its utmost capacity, the limb lying semiflexed and on its outer side. Left to itself, the capsule gives way, and suppuration rapidly extends upwards beneath the vasti or down- wards into the leg, the pus ultimately finding its way to the surface. The deformity gradually increases, until in the worst forms the tibia slips behind the condyles of the femur, the leg is flexed to a right angle and rotated outwards, and if the limb has long rested on its outer side, considerable lateral displacement may also occur. Early and efficient treatment will usually prevent such a disaster. The joint should be freely incised on each side of the patella, so as to open up the subcrureal pouch, and the whole articular cavity well washed out. In some cases a counter-opening may be made with advantage and a drain-tube inserted, by passing a pair of sinus forceps through the outer portion of the posterior ligament of Winslow, and cutting down on it to the inner side of the biceps tendon and clear of the ex- ternal popliteal nerve. By this means more efficient drainage of the articular cavity is obtained. When the Ankle-joint is involved, amputation has often to be resorted to, in consequence of the difficulty of securing good drainage, although excision of the astragalus will sometimes cut short the disease and lead to a good result. Special Forms of Synovitis and Arthritis. Rheumatic Synovitis is met with in the course of acute rheu- matism, or as a chronic affection from the commencement. The former is recognised by the presence of fever, acid sweats, high- coloured urine loaded with lithates, and a tendency to metastasis, one joint after another being involved ; complete resolution usually follows, but there may be some thickening of ligaments and consequent impairment of mobility. If the disease is limited to one joint, absolute disorganization, though without suppura- tion, may ensue (acute rheumatic arthritis). The chronic variety is characterized by swelling of the joints, due partly to effusion, partly to thickening of the synovial mem- brane and of the capsular and other ligaments. If neglected, it may produce fixity of the joint, due mainly to ligamentous changes, but also resulting from the development of intra-articular adhesions ; but there is never any lipping of the cartilages or new formation of bone, as in osteo-arthritis. Not unfrequently other evidences of rheumatism may be present, such as chorea, ery- thema, etc., whilst rheumatic nodules {i.e., new growths of fibrous tissue in the subcutaneous tissues, perhaps reaching the size of a walnut, but more often much smaller) may also develop. 584 A MANUAL OF SURGERY The Treatment of the acute form is rather constitutional than local, and consists in the administration of large doses of salicy- late of soda ; at first, when the temperature is considerably raised, 20-grain doses are given every three or four hours, but as the pyrexial phenomena disappear, these are gradually diminished in frequency and amount, until merely io-grain doses are given thrice daily. Some patients cannot take salicylates, as they induce maniacal attacks of alarming severity ; under these circum- stances the practitioner must depend on quinine and bicarbonate of potash. Locally, the joints should be wrapped in warm cotton- wool, or, perhaps better, soda fomentations may be applied. Should the inflammation resist such measures, it is quite justifiable to open and wash out the joint, which is found to be occupied by a greenish, semi-puriform effusion. In the more chronic forms salicine and iodide of potash are perhaps more effectual, together with alkaline mineral waters, whilst stimulating friction and massage may also be adopted. Counter-irritation in the form of frequently repeated blisters, or even of the actual cautery, may prove beneficial ; localized hot- air baths may also be used with advantage in the earlier stages. Failing such treatment, a visit to some of the home or Continental spas may be recommended. Gouty Arthritis is characterized by certain well-marked features. It often attacks the metatarso-phalangeal articulation of the great toe (podagra), or the metacarpo-phalangeal joint of the thumb (cheiragra). Its onset is usually sudden, and it frequently com- mences in the middle of the night. The tissues around the joint become swollen, red, shiny, and cedematous, whilst the super- ficial veins are prominent. The attack is exceedingly painful, and the skin exquisitely tender. These symptoms pass off in the course of a few days, leaving the articulation swollen and sensitive. Even a single attack results in a slight deposit of biurate of soda in acicular crystals in the matrix of the articular cartilage close to the surface ; but when the joint has been several times inflamed the whole thickness of the cartilage may be invaded by this chalky deposit, whilst the ligaments and ends of the bones are also infiltrated. In the smaller joints it may increase to such an extent as to form well-marked swellings, or ' tophi,' similar in character to those so commonly seen in the external ear. The skin sometimes gives way over these, and a chalky discharge results. In some cases the cartilages are eroded, and eburnation of the exposed bone may follow, as in osteo-arthritis. The treat- ment of acute gout consists in well fomenting the parts or applying glycerine of belladonna, whilst colchicum, citrate of lithia, and alkaline purgatives are administered. In the more chronic forms iodide of potassium, and possibly piperazine, may be given, and the diet and drink are carefully regulated. DISEASES OF JOINTS 585 Pyasmic Synovitis is due to embolic infection from some sup- purating focus. The joint becomes rapidly distended with pus, and often without pain. If the joint is promptly opened, washed out and drained, its disorganization may be in many cases pre- vented (vide Pyaemia, p. 106) ; otherwise destructive changes will quickly follow. Typhoid Disease of Joints. — Several well-defined varieties of joint trouble arise in connection with typhoid fever. 1. A simple chronic synovitis occurs in one or more joints with but slight effusion and little inflammatory disturbance. It is somewhat resistant to treatment, and hence may cause limitation of movement. Possibly it is due to the action of toxins rather than of the living organism. 2. The tvue typhoid arthritis, due to the Bac. typhosus, is character- ized by a marked inflammatory effusion into one or more joints, and is liable to end in spontaneous dislocation. The hip-joint is specially liable to this trouble. Suppuration, however, is rare, and the prognosis good, provided the limb is kept in a good position. The presence of a large effusion indicates aspiration. 3. A mixed pyogenic and typhoid infection results in active suppuration within the joints, the Bac. typhosus playing quite a subsidiary part. 4. A pure pyogenic infection. In these latter two varieties the ordinary symptoms of acute suppurative arthritis occur, and the treatment for that affection must be instituted. Pneumococcal Arthritis. — In the course of an acute pneumonia the pneumococcus is occasionally disseminated through the body, and is then very likely to attack a joint which has been already damaged, giving rise to a suppurative arthritis, with an effusion of thick creamy pus, or sometimes to a milder form of synovitis. Males are more often affected than females, and the upper rather than the lower extremity. Occasionally more than one joint is involved, and, with the exception of the hip, the larger joints are attacked rather than the smaller. There are no special peculiarities in the course of the disease, but it must be recognised as merely part of a general infection, and hence a high mortality is associated with it. Suppuration usually occurs, and its onset is always an indication for incising, washing out, and draining the joint. Gonorrhceal Disease of Joints is always due to infection with the gonococcus, transmitted by the blood from the primary focus of mischief. Naturally, it is usually seen in connection with gonorrhceal urethritis, but it has been known to follow ophthalmia neonatorum, and has been lighted up by passing a full-sized bougie on a patient with gleet. Under ordinary circumstances it generally commences after the third week of the gonor- rheal attack, when the discharge is becoming subacute. It may attack one or many joints, the knee, ankle, and wrist being 586 A MANUAL OF SURGERY most frequently involved, and perhaps on both sides of the body. Two distinct types of trouble may manifest themselves, but they are not unfrequently combined. In one, the synovial membrane is mainly affected, and the effusion is chiefly intra-articular, so that the condition closely resembles an ordinary attack of acute traumatic synovitis. In the other, the peri-articular structures bear the brunt of the mischief; and there is at first but little effusion in the joint, but much around it, the parts even becoming cedematous ; the ligaments are infiltrated and softened, so that displacement readily occurs ; surrounding muscles atrophy rapidly ; the patient suffers from severe pain and a good deal of fever, so that he becomes thin and worn. In the worst cases the intra-articular effusion increases and is sero-purulent, yellowish-green in colour, and contains flakes of lymph, but it is never truly purulent. Both forms are very chronic and resistant to treatment, and hence ankylosis, with or without disorganization, is very liable to follow. Treatment is not very satisfactory. The urethral discharges must be arrested as soon as possible, whilst the affected joints are kept at rest ; moderate pressure and counter-irritation, as by Scott's dressing, are perhaps the best means of dealing with the later stages in simple cases. Iodide of potassium, mercury, and quinine may be administered internally. Should the local phenomena be at all severe, the joint must be opened, irrigated, and drained, but even then ankylosis is likely to follow. Tuberculous Disease of Joints. Tuberculous Arthritis {Syn. : Pulpy Degeneration of the Synovial Membrane, White Swelling, etc.) may commence either in the synovial membrane or in the articular end of the adjacent bone (tuberculous epiphysitis, p. 518) ; or it may spread from the periosteum to the synovial membrane, as a result of a tuber- culous periostitis, or from a neighbouring bursa. There is some slight difference of opinion as to the relative frequency of the synovial and osseous varieties, but the latest investigations cer- tainly seem to indicate that in children the disease commences most frequently in the epiphyses, whilst in adults it may start either in membrane or bone with about equal frequency. The Causes may be summed up as follows : The individual is predisposed to the development of tuberculous disease, usually as the result of an inherited tendency, a family history of tubercle being often obtainable ; the general health of the patient may be at fault, owing to insufficient or inappropriate food, bad hygienic surroundings, or exposure to cold. Some slight injury of which but little notice is taken may lead to the actual deposit of the Bac. tuberculosis, which gains access to the body through some breach of surface, or even perhaps through a healthy mucous membrane. Severe articular lesions, such as dislocations, are DISEASES OF JOINTS 587 much less likely to induce tuberculous disease, partly because their gravity demands efficient treatment, partly because the activity of the reparative process is capable of dealing with the organisms, even if they are brought to the spot. Pathological Anatomy. — The synovial membrane becomes thick- ened, pulpy, and cedematous, and in the early stages, on naked-eye examination, may be found to be studded with small gelatinous nodules, about the size of a pin's head, situated immediately beneath the serous lining ; later on, these may amalgamate into caseous masses which burst and discharge into the joint, leaving ulcerated surfaces. Finally, the synovial membrane is changed into a so-called pyogenic membrane, consisting of granulation tissue similar to that lining the cavity of a chronic abscess, and more or less closely attached to the surrounding structures, which are transformed into cedematous fibro-cicatricial tissue, whilst the superficial parts undergo fatty or necrotic changes. Micro- scopically, one finds all the ordinary appearances of tuberculous disease, the vessels being in a state of endarteritis for some distance from the serous surface. Fringes of the synovial membrane, swollen and succulent, spread over the margins of the articular cartilage, and as they increase in size become adherent to it, just as, according to Billroth's classical description, ivy creeps along a wall. On lifting the edges of these fringes, the underlying cartilage is found hollowed out and eroded. As soon as the whole thick- ness is destroyed at any one spot, the cancellous tissue at the end of the bone becomes similarly affected, and the granulations spread along under the cartilage, cutting it off from its nutritive supply, and thus necrosis, as well as superficial ulceration, may assist in its destruction. As a result of the hyperaemic condition of the end of the bone, especially when sepsis is super-added, a new formation of subperiosteal osteophytes, stalactitiform in character, sometimes takes place, but not to such an extent as in acute arthritis. Occa- sionally the periosteum itself is involved in the tuberculous process, and the disease may then extend some distance from the joint. When the bone becomes involved, either primarily or secondarily, any of the manifestations of tuberculous disease described in Chapter XVIII. may be met with, and thus it is not uncommon to find sequestra in connection with tuberculous arthritis. When it originates in the bone in adults, the tissue directly contiguous to the articular cartilage is often that primarily attacked ; but in children it more frequently starts in connection with the epiphyseal cartilage. The joint is usually infected by extension of the disease through the articular cartilage, but when the synovial membrane extends along the bone beyond the cartilage, the latter structure may escape. Sometimes a pre-tuberculous synovial effusion of a simple nature occurs, but gives place to the more typical mani- festations when infection has followed. Should the perforation be a large one, e.g., when a tuberculous abscess bursts into a joint, 5»» A MANUAL OF SURGERY f- S '•''■ ? I acute symptoms supervene, but gradually quiet down, and the usual chronic phenomena subsequently develop. More com- monly the infection is slow and gradual, and the onset of the articular symptoms is of a similar character. The extent of the mischief in the bones may sometimes be ascertained by the X rays (see Plates XXVIII. and XXIX.). Clinical History. — The disease usually commences in a most insidious manner. It may be dated back to some injury, but as often as not no such occurrence has been noted. Slight impairment of movement, together with some pain, especially when the limb is jarred or twisted, is perhaps the first sign, causing the patient to limp if one of the lower extremities is involved. This becomes more and more marked, and the joint is fixed, usually in a semiflexed posi- tion, whilst it looks slightly swollen. On inspection it is white, smooth, and rounded, the swelling being more apparent on account of the wasting of adjacent muscles. On palpation, the part is found to be hotter than that on the opposite side of the body, whilst fluctuation is not readily detected, there being but little fluid in the joint, though the affected tissues are elastic and puffy. In a few rare cases, where the synovial membrane is widely involved, the affec- tion commences with consider- able serous exudation, giving rise to the condition known as tuberculous hydrops ; after persisting for a while, the usual manifestations of the disease show themselves. According to Konig a number of joints may be Vc^ Fig. 212. — Bones entering into For- mation of Knee-joint, which has been disorganized by tuberculous Disease. (From College of Sur- geons' Museum.) The cartilage is almost entirely de- stroyed, and the exposed bone is carious and eroded. PLATE XXVIII. Tuberculous Disease of Knee-Joint, showing Invasion of Patella. To /ace p. 588.] DISEASES OF JOINTS 589 affected with hydrops in the first place, but all clear up except one, and that becomes tuberculous. In this type fibrinous melon-seed bodies are occasionally found. From time to time exacerbations of pain and increase of swelling occur, which subside after a few days, but leave the joint more and more crippled. Sooner or later abscesses are likely to develop, with increased local disturbance, and often starting pains at night, due to the erosion of cartilages, together with slight general fever and malaise. If they burst, temporary relief follows ; but if the discharge continues, and fresh abscesses form, septic phenomena are usually added to those already present. The patient develops a hectic temperature ; amyloid degeneration of the viscera may supervene, the joint becomes more and more deformed, abnormal movements from relaxation of ligaments may exist, and finally the patient, exhausted partly by the discharge, partly by the pain, and partly by the want of sleep, becomes emaciated, and may even die, unless prompt measures are taken for his relief. Results. — (a) If seen in the early stages, and suitably treated, the disease may be entirely cured, and a moveable joint result. (b) More frequently the articular structures are so severely damaged, that a cure can only be established by means of anky- losis. Unless measures have been adopted to maintain the limb in a satisfactory position, permanent deformity may ensue. (c) If sepsis has been admitted, the patient will probably develop hectic or amyloid disease from chronic toxaemia, and from this he may succumb. On the other hand, in a few instances he may survive such dangers, the sinuses alternately drying up and discharging, although he remains a permanent invalid, and the joint is crippled, (d) Acute miliary tuberculosis is occasionally met with as a complication of this affection, whilst similar associated disease of the lungs, brain, kidneys, or other viscera, may be lighted up. The Prognosis is mainly influenced by the condition of the individual and his surroundings. In children of the better classes, where every hygienic and medical assistance can be given, re- covery generally follows, unless there is a strong counterbalancing hereditary tendency. Amongst the poorer classes, and especially in ' slum children,' the outlook is correspondingly serious. More- over, the extremes of life are unfavourable : babies resist tuber- culous invasion badly, and patients over fifty have comparatively little recuperative power ; hence radical rather than conservative measures have often to be resorted to in these two classes. The Treatment of tuberculous joints varies not only with the articulation affected, but also with the type of patient, and the extent to which the disease has advanced. 1. Hygienic Treatment. — Local tuberculosis is a manifestation of a general condition of weakness which can often be eradicated 59Q A MANUAL OF SURGERY from the system by suitable constitutional treatment. Conse- quently, in the early stages, many cases of tuberculous synovitis can be cured by keeping the limb absolutely at rest, by means of splints, plaster of Paris, etc., and elevating it if there is much pain. The general health should be improved by sending the child to the seaside, giving it plenty of good food, and administering cpd- liver-oil and syrup of the iodide of iron. An endeavour must be made at the same time to correct any faulty position of the limb by a process of gradual extension, made at first in the direction of the displacement, and with only just sufficient energy to keep the joint surfaces at rest and counteract the tonic muscular con- traction which is tending to produce a fixed deformity ; it may be necessary to employ tenotomy for this purpose. Any form of apparatus which depends upon a screw mechanism to straighten out a limb is certain to increase intra-articular tension, and there- fore is not to be used. The sudden application of force under an anaesthetic is also unadvisable, since tuberculous material may thereby be disseminated through the system. Counter-irritation by blistering or iodine paint, or combined with pressure in the form of Scott's dressing, is often useful in promoting repair. Possibly the severe pain experienced when the contiguous osseous tissues are involved may be relieved by an application of the actual cautery, but it is doubtful whether the progress of the disease can be checked by such means. 2. Parenchymatous injections of iodoform suspended in glycerine into the articular cavity, or into the substance of the synovial membrane, have been much recommended of late, and have apparently done good ; 10 parts of iodoform are mixed with 20 of sterilized water, and made up to 100 with pure glycerine, and about an ounce of this fluid is injected. The limb is at the same time immobilized. The injection usually needs to be repeated more than once. /3-naphthol and some other antiseptics have also been employed in a similar fashion. 3. A new plan of treatment was suggested by Bier of Kiel a few years back ; it consists in inducing venous engorgement of the diseased tissues by applying an elastic bandage above and below the joint, but only loosely over it ; the pressure is kept on for two or three hours daily, if the patient can bear it, and during the intervals a splint is applied. The general health must also be attended to during the treatment. The process is based on the observation that phthisis rarely develops in association with mitral regurgitation, whereby pulmonary engorgement is induced ; whilst if the cardiac lesion supervenes in a phthisical subject, the lung symptoms improve. It is too early yet to say what the final verdict as to this method will be, but the results hitherto gained are encouraging.* It must never be employed when septic * Archiv. j. klin. Chirwgie, vol. xlviii., bd. ii., p. 306. DISEASES OF JOINTS 591 sinuses are present, as it considerably aggravates the trouble by providing increased pabulum for the micro-organisms. 4. Abscesses are, if possible, dealt with sufficiently early and in such a manner as to obviate the need for prolonged drainage. To this end they must never be left long enough to allow the skin and subcutaneous tissues to become involved, but as soon as a collection can be detected it should be tapped by a large trocar and cannula, the cavity well irrigated, and injected with iodoform emulsion. It is wise to incise the skin with a knife, and not to puncture it with the trocar ; the irregular wound made by the latter might not heal quickly ; a stitch closes the incision and assists satisfactory healing. Of course, when the skin is reddened, and the pus subcutaneous, the abscess must be incised and drained in the usual manner, any thin and undermined skin being snipped away. 5. In other cases where expectant treatment cannot satis- factorily be carried out, or where the disease is progressing, arthrectomy, or total removal of the diseased tissues with the least possible disturbance of the parts, should be undertaken. This treatment is only feasible in certain joints, viz., the elbow, knee, and ankle, which can be readily reached, and more or less efficiently dealt with. It consists in freely opening the articular cavity, and cutting or scraping away the diseased membrane, whilst carious foci in the bone are scraped and purified. The advantages claimed for it are, that it interferes neither with the immediate length nor with the subsequent growth of the limb, and that no bone is cut through, and hence risk of tuberculous infection of this structure is avoided. As to its practical value — if the proceeding is limited to the synovial membrane, we have little confidence in it, recurrences being frequently met with ; but if it is modified in the knee and ankle by the additional removal of a thin slice of articular cartilage, so that it is converted into a limited excision, and osseous ankylosis between the two epiphyses is obtained, good results may be anticipated. At the knee, however, there is some tendency to subsequent flexion and dis- placement. 6. Excision is at the present time being utilized much less frequently in the treatment of tuberculous joints than a short time back, owing to increased confidence in conservative measures ; it is quite possible that this neglect of operation is being carried too far. We advise its employment under the following circum- stances : {a) To cut short the course of the disease where con- stitutional and expectant treatment cannot be efficiently carried out, or where owing to constitutional weakness or defective hygiene it has failed ; (b) where extensive superficial abscesses have formed, requiring prolonged drainage, and the disease has seriously involved the bones ; (c) for total disorganization of the joint ; (d) to prevent ankylosis in certain joints, viz., the elbow 592 A MANUAL OF SURGERY and temporo-maxillary ; and (e) to remedy ankylosis in a faulty position. In determining whether or not excision is advisable, the following considerations must be passed under review : (i.) The operation makes a considerable call upon the recuperative powers of the individual, and hence is not to be recommended in infants or in patients of advanced age. Various age-limits are given by different authorities, but, speaking generally, we would say that the operation should only be undertaken upon those between five and forty-five years of age. In infants arthrotomy, or at most arthrectomy, is all that is practicable ; the ends of the bones are so largely cartilaginous that extensive osseous trouble is not likely to be present. In the hip-joint, however, removal of the head of the femur often gives excellent results even in the young. The latter limit depends more on the vitality than on the actual age of the individual, whilst some joints are more amenable to excision in elderly patients than others ; thus, one would excise the knee or shoulder in cases where one would not think of dealing with the wrist, ankle, or elbow in this manner, (ii.) More- over, the general health of the individual must be sufficiently good, otherwise repair will not be satisfactorily accomplished. Hectic and amyloid disease, unless very advanced, do not contra- indicate this proceeding, but in weakly children living in the slums it is often better practice to amputate, (iii.) The extent of the disease in the bones is also a matter of importance, since, if a large amount of bone has to be removed, a shortened or flail-like, useless limb is almost certain to follow. More bone can, however, be removed without detriment in the upper than in the lower extremity, (iv.) Again, the disease must not have invaded the soft parts too extensively ; if the skin is unhealthy and riddled with sinuses, removal of the limb is often preferable, (v.) Finally, no acute or subacute septic trouble should be present, for fear of lighting up similar disease in the bones. Under such circum- stances the limb may sometimes be saved by making free incisions to relieve tension, and deferring excision until the more active symptoms have subsided. 7. If, after carefully weighing the preceding considerations, excision is not thought desirable, and the case is steadily pro- gressing from bad to worse, amputation would appear to be the only treatment available. In addition, it is indicated in patients where excision has been undertaken and failed, either from the limb becoming subsequently flail-like or useless, or from recurrence owing to incomplete eradication, or from the advent of sepsis. Lastly, if the disease is present in two joints at one time, or in a joint and some other organ, neither of which is improving, total removal of one focus of mischief will often induce a rapidly favour- able change in the other. DISEASES OF JOINTS 593 Tuberculous Disease of Special Joints. The Shoulder -joint is but rarely affected in children, and not very commonly in adults. The disease usually starts in the head of the humerus, affecting subsequently the synovial membrane, and perhaps also the glenoid cavity. If abscesses form, they are likely to point either in front of or behind the deltoid, in the former case extending along the synovial membrane lining the bicipital groove. Excision of the head of the bone is almost always required in order to effect a cure. In the Elbow the disease is most common in young adults, and is often primarily osseous, commencing in the olecranon or outer condyle of the humerus. If the synovial membrane is first affected, it frequently starts in the superior radio-ulnar articula- tion. The swollen synovial membrane bulges on either side of the olecranon and tendon of the biceps. Sinuses form by the side of the olecranon, or an abscess may burrow upwards along the ulnar nerve and open on the inner aspect of the arm. Prolonged immobilization, followed, if need be, by incision and partial removal of the synovial membrane, often suffices in children, leaving, however, a stiff elbow ; in adults excision is the correct practice, and the results are very satisfactory, provided that a sufficient amount of bone is removed, and the muscular attach- ments interfered with as little as possible. If expectant treatment is adopted, the arm should be flexed to a right angle, and with the hand midway between pronation and supination, so that, if ankylosis follows, the limb may be in the most useful position. Arthrectomy is occasionally adopted, and is best accomplished by means of an H-shaped incision over the olecranon, which process of bone is divided at its base and turned upwards, so as to thoroughly expose the interior of the articulation. After removing all diseased tissue, the olecranon is replaced and wired to the shaft of the ulna. In the Wrist diffuse disease of the synovial membrane and bones is met with, starting most frequently from the former structure ; if primarily osseous, it usually commences in the lower end of the radius. It may also extend from a tuberculous affec- tion of the adjacent tendon sheaths. A characteristic doughy swelling forms over the dorsum, displacing the extensor tendons, and sinuses often develop on the dorsal aspect or by the side of the flexor carpi radialis tendon. Conservative measures may bring about a cure, and every effort should be made to avoid excision, since the result of this proceeding is almost always the production of a weak and flail-like hand, so that the constant use of a leather support is essential after healing has occurred. In elderly people amputation is often the only resource. Diseases of the Hip-joint and of the Sacroiliac Articulation are separately considered (pp. 611 and 619). 38 594 A MANUAL OF SURGERY The Knee-joint is, perhaps, more often affected with tuber- culous disease than any other articulation. It appears to start in the synovial membrane or bone with almost equal frequency ; if the bones are first affected, the primary focus is usually situated on the inner aspect of either the femur or tibia. Sequestra are found in nearly one half of the cases in which the bone is affected, becoming more frequent as the age advances. The disease runs a typical course, and needs no special comment. When the joint has become disorganized, the tibia is liable to be displaced horizontally backwards, flexed and externally rotated, and anky- losis in this position is difficult to remedy, even by operation. Prolonged immobilization on a back-splint, or, preferably, the application of a Thomas's knee-splint (Fig. 213), together with iodoform injections and constitutional treatment, will be effectual in many cases. Failing this, a modified arthrectomy may be undertaken, and to carry it out an incision should be made across the front of the joint from condyle to condyle, as for an excision, dividing either the liga- mentum patellae, or perhaps the patella, which is subsequently wired together. The whole of the synovial membrane is then dis- sected away, special attention being directed to the subcrureal pouch and the back of the joint. A thin slice should be removed from the surfaces of both tibia and femur, and if the epiphyseal cartilages are not encroached upon, the growth of the limb is not impaired to any great extent, although it may become irregular and lead to some deformity, e.g., well-marked flexion, or genu-recurvatum (p. 398). In suitable cases, where the bones are not too extensively involved, so that on section broad healthy surfaces can be apposed, excision is a most satisfactory operation, provided that the bulk of the synovial disease can be removed. In adults, where it is desirable to cut short the disease, one may always undertake this proceeding when the patella has become fixed to the femur, thereby determining ankylosis. Re- currence usually results from a focal point of disease being left in the synovial mem- plied. brane or in the bone. If amputation is necessary, the supra-condyloid operation can generally be adopted ; when the joint has been already resected, or sinuses still persist in front, a long posterior flap is often the only healthy tissue available for covering the bone. Fig. 213. — Thomas's Knee-splint ap- DISEASES OF JOINTS 595 The Ankle-joint. — Tuberculous disease of this joint usually com- mences in the synovial membrane rather than in the bone. If primarily osseous, the astragalus is more frequently affected than the lower end of the tibia. The whole region becomes occupied by a pulpy swelling, which first pushes forwards the extensor tendons and bulges in front of the malleoli, and subsequently appears on either side of the tendo Achillis. The foot is maintained in a position of plantar-flexion so as to bring the narrower portion erf the upper surface of the astragalus into the tibio-fibular mortice. Flexion and extension of the foot are of course lost, but with care the lateral movements (inversion and eversion) which occur at the mid-tarsal and sub-astragaloid joints can be undertaken without pain. In the early stages prolonged rest and immobilization in plaster of Paris are all that is required. Excision of the joint gives fairly satis- factory results in adults, but not unfrequently fails to eradicate the disease, owing to the fact that, when once the astragalus is involved, the tuberculous process is likely to spread to the articulations placed beneath it, and so to the other bones of the foot. When there is any doubt as to the condition of the astragalus, that bone should be removed at the same time as the lower ends of the tibia and fibula. Where the disease is more extensive, a supramalleolar amputation of the foot will be necessary. For diseases of the Bones and Joints of the Foot, see p. 515. Syphilitic Diseases of Joints. Although syphilitic disease of joints is rare in proportion to the prevalence of syphilis, yet several varieties have been differentiated and recognised. (1) In the later stage of the secondary period a chronic form of synovitis occurs, evidenced by passive effusion into the joint, with or without pain, and usually persisting for some time. Any joint may be attacked in this way, perhaps the knee most commonly, and the affection is often symmetrical in its dis- tribution. The effusion may be only slight, but is frequently very considerable (hydrarthrosis), and a marked feature in the condition consists in the rapid variations in the amount of swelling, even from day to day. In some few cases this affection resists all treatment, and leads to ultimate disorganization. (2) Gummatous inflammation of the perisynovial fibrous tissue, which may or may not extend to the adjacent bone, is met with in the tertiary period. It either appears as a localized hard nodule, resembling in measure a fibrous tumour, and then causing but little trouble beyond a sense of painful weakness in the articulation ; or it is more diffuse in its distribution, leading to a moderate effusion, and later on to much thickening and infiltration of the capsular and other ligaments, and resulting in considerable impairment of its move- ments from cicatricial contraction. Some of these gummatous nodules may break down and ulcerate. (3) A diffuse gummatous infiltration of the synovial membrane itself is also seen. It closely 38—2 596 A MANUAL OF SURGERY simulates a tuberculous synovitis, from which it is often impossible to distinguish it, except by the rapid onset and the presence of other syphilitic phenomena. (4) A chondro -arthritis, described originally by Virchow, is the syphilitic analogue of osteo-arthritis. It commences by fibrillation of the matrix of the cartilage, and proliferation of the cells. The cartilage softens, and becomes eroded by friction of the articular surfaces. The bone thus exposed is worn away, and curiously ' pitted ' and excavated. It is recognised from osteo-arthritis by the facts that there is usually but little or no pain ; that the eburnation of the exposed bone is less extensive, and therefore crepitus is but little marked ; whilst the typical osteophytic growths, causing ' lipping ' of the joint margins, are absent. The eroded areas, moreover, do not corre- spond with the sites of intra-articular pressure, and are more rounded and punched out, and not arranged in linear grooves, as in the latter disease. It is not uncommonly associated with a gummatous thickening of the synovial membrane, and, indeed, the hollows or pits above mentioned may be filled with caseous material, derived from degeneration of this tissue. The Treatment in the early manifestation consists in the administration of mercury, and the judicious application of pres- sure with or without immobilization, according to the require- ments of the case and the joint affected. In the tertiary forms iodide of potassium in gradually increasing doses has a rapidly beneficial action, which confirms the diagnosis ; it may be occasionally combined with a small amount of mercury, either given internally, or applied locally if any ulcerative lesion exists. In the most pronounced cases, where the pain is severe and disorganization of the joint has occurred, excision may be neces- sary, and the results are often very satisfactory. Osteo-arthritis. Although this disease is extremely common in this country and has well-marked characteristics, its nature is still extremely obscure, as is evident from the large number of names that have been applied to it, such as chronic rheumatoid arthritis, rheumatic gout, arthritis deformans, arthritis senilis, arthritis sicca, etc. There is not the slightest doubt that several distinct types of disease have been confounded together under this title, and although at the present time it is admitted that rheumatic and gouty conditions are to be excluded, yet it is probable that we are still including more than one type of chronic articular trouble. etiology. — Exposure to damp and cold is doubtless an im- portant factor in the production of osteo-arthritis, especially in elderly people, or when some depressed condition of the nervous system is superadded, whether such be due to worry, anxiety, or to defective nutrition. In other cases where there is no question of exposure, the affection is by some attributed to nervous influences (Senator, Ord), and particularly to affection of the DISEASES OF JOINTS 597 uterus and ovaries, which it is supposed are capable of inducing reflex changes in the joints. Such an idea may explain some of the trophic and nervous phenomena associated with this trouble, but it is a little difficult to accept the theory in its entirety. Others again attribute it to auto-intoxication due to indigestion of duodenal origin. Recently a theory of bacterial causation has been propounded, and although it cannot be considered as proven, yet evidence in favour of its probability is steadily accumulating. It is supposed that the organisms find their way into the joints from some other focus of infection, and in this connection it is interesting to note the statement that in a large series of cases 55 per cent, were preceded by some other infective fever or disease (Bannatyne). They develop in the joints and produce toxic bodies which act locally by inducing destructive phenomena of a special type, whilst by their general absorption various trophic and nervous symptoms are caused, whose existence has been constantly noted, but for which hitherto there has been no adequate explanation. Such an origin will also explain the presence of enlarged glands in the neighbourhood of some of the affected joints. Several observers have found bacteria within the joints, and Bannatyne and others have described a short bacillus, the ends of which stain deeply whilst the intervening portion remains unstained, causing it to look like a diplococcus. This was found in several cases, but though injected into the joints of animals, no results followed. Traumatism plays an important part in the production of certain types of osteo-arthritis, and Lane is emphatic in maintaining that these cases should be relegated to a different category, and be known as chronic traumatic arthritis; the changes, however, are so similar to those of osteo-arthritis that we prefer to consider it a sub- division or variety. The injury may be slight in nature, such as a sprain or strain, or more severe, such as a fracture or disloca- tion involving the articular surface ; thus, it is not uncommon to see it following Colles's fracture or one of the cervix femoris. Abnormal pressure maintained for a long time also causes changes of a similar type, and thus many of the joints of labouring men are deformed in a peculiar fashion, according to the special type of work and the particular joints that are exposed to strain. Pathological Anatomy. — The disease commences in the articular Fig. 214. — Patella from Early Case of Osteo-arthritis, show- ing Fibrillation of Cartilage. (Howard Marsh.) 598 A MANUAL OF SURGERY cartilage, the matrix of which cracks and undergoes fibrillar changes, and presents a villous appearance, resembling the pile of velvet (Fig. 214). The cartilage cells proliferate, so that the capsules contain many instead of one, and these, giving way, dis- charge their contents into the joint. The cartilage thus softened is readily worn away by the movements of the articulation, and the exposed surface of bone becomes hard, sclerosed, and polished like ivory (eburnated). This usually occurs in certain definite directions. In hinge joints the surfaces become grooved longi- tudinally, whereas in ball-and-socket joints, like the hip, the head is eroded in a circular manner. This condensed tissue does not extend very deeply, and immediately beneath it the cancellous bone is of a more open texture than usual, and filled with fatty me- dulla. In spite of the sclerosis, the articular end of the bone is con- tinually being worn away, and this may go on to such an ex- tent as to lead to actual shortening of the limb. Concurrently with this destruction, new bone formation is taking place at the margins of the articular carti- lage, producing irre- gular osteophytes, which have been likened to the gutterings of a candle. They are \ ■ [\ preceded by an over- k_ _^ -—- . : , ; growth of cartilage, in which ossification Fig. 215.— Late Stage of Osteoarthritis of takes place secondarily. Knee, showing Destruction of the Articu- when qnrh nnrrrrnwrrU lar Cartilage, and Eburnation of the ^ vnen sucfl outgrowths Exposed Bone in Longitudinal Grooves. n& ve been produced (From College of Surgeons' Museum.) more or less evenly The margins of the surfaces are distinctly lipped, around the joint mar- gin, a characteristic 'lipping' of the edge of the cartilage results (Fig. 215). % Some- times these osteophytes attain to a large size, and by interlocking may lead to ankylosis of the joint- The synovial membrane is usually thickened, and the villi occasionally proliferate, and may reach such dimensions as to be felt through the skin, rolling under the finger. They are red, vascular, and succulent during life, but after removal and preservation in spirit, they look DISEASES OF JOINTS 599 shrunken and insignificant. This overgrowth is often associated with excessive effusion, though usually the affection is of a dry type. Occasionally cartilaginous nodules develop in the villi of the synovial fringes, later on becoming ossified, and if detached constitute one form of loose cartilage. Clinical History. — Several distinct types of. this disease may be observed, but practically they may be subdivided into three chief groups : A chronic type involving one joint only ; a chronic form affecting many joints ; and an acute variety which is also poly- articular. i. The chronic monarticular variety is that most frequently seen by surgeons, and is constantly brought about by injury. Pain and creaking of the joint on movement are the early symptoms of this affection. There may be very little swelling, unless effusion is present, but pain, especially at night, is most trouble- some, being usually increased on changes of weather, particularly if rain is threatening. The pain and stiffness are most marked after keeping the parts at rest, and diminish when the limb is used. As the disease progresses, the movements become more and more impaired, and the crepitus more of an osseous type ; the ends of the bones are felt enlarged and lipped, and deformity soon becomes obvious. Exacerbations in the symptoms occur from time to time, resulting in increased crippling of the articulation. Finally, the limb may become absolutely useless, partly from the pain and partly from the limitation of movement produced by the osteophytes. Wasting of the adjacent muscles is also a marked feature. It is usually seen in elderly people, and may supervene very quickly after an accident, such as fracture or bruising of the cervix femoris, and then the destructive phenomena may progress at a rapid rate. When it appears in younger people, the osseous lesions are much less evident. 2. The chronic polyarticular variety arises independently of trau- matism, and is most commonly seen in females of middle life. It may commence in one joint and spread to others, or it may appear in many joints simultaneously. Most frequently one or more of the phalangeal articulations is the starting point, par- ticularly the terminal ones. The joints become stiff and swollen, are tender, and small nodular bony outgrowths develop at the bases of the phalanges, which are known as Heberden's nodosi- ties. The trouble gradually spreads to other joints, and although there are often remissions, yet the condition progresses steaddy until the patient may be entirely crippled thereby. Well marked overgrowth of bone and eburnation of the articular ends are characteristic features of this type. Sometimes there is consider- able effusion, accompanied by overgrowth of the synovial villi, but this is unusual. 3. The acute polyarticular variety does not often come to the surgeon for treatment, at any rate in the early stages. It usually 6oo A MANUAL OF SURGERY attacks young or comparatively young people, and females rather than males, frequently following some infective trouble, such as influenza, scarlatina, tonsillitis, etc. It is often ushered in by a distinct febrile attack with persistent increase in the rate of the heart-beat ; trophic and vasomotor phenomena are often co- existent, such as patches of pigmentation, clammy cold hands, and rapid muscular atrophy. The smaller joints of the hands and feet are mainly affected, and that more or less symmetrically, although the terminal interphalangeal articulations often escape. The capsules are distended with a certain amount of effusion, and at first there is but little osseous mischief. In not a few cases a very characteristic deformity in the shape of ulnar adduction of all the fingers occurs. Gradually the trouble spreads to other and larger joints, and osseous manifestations appear ; but the progress is slow, and may be to a large extent arrested by treatment. Neighbouring lymphatic glands may be enlarged in the early stages. It is important to note that gouty and rheumatic troubles may be associated with osteo-arthritis ; the rheumatic affections may precede, the gouty usually follow. The Diagnosis of osteo-arthritis per se is not often difficult in a well-marked case, the crepitus, pain, and enlargement of the ends of the bones, together with the slight amount of effusion, constituting a tolerably characteristic picture. From simple chronic synovitis it may be known by the history and smaller amount of effusion, and by the pain and rigidity being frequently more marked after rest, and diminishing after the joint has been actively used. There is more difficulty in distinguishing the form associated with increased effusion and enlargement of the synovial villi ; careful examination may, however, enable the surgeon to make out these villi moving to and fro in the joint under his hand, whilst possibly the ends of the bone may be lipped. For diagnosis from chronic rheumatism and Charcot's disease, see pp. 583 and 604. The diagnostic points between polyarticular osteo-arthritis and gout are suggested in the following table : Osteo-arthritis. Gout. Sex : Females : Males : Type of patient. Poor, ill - nourished, de- Well - to - do and well- pressed, anxious; often ex- nourished people. posed to damp and cold. Onset. Insidious. Sudden and obvious. Locality of onset. Usually in hands, espe- Feet, especially metatarso- cially in the thumb. phalangeal joint of great toe. Type of attack. No obvious swelling or Red and painful at first, redness. with skin shiny over the joint. Pain. Slight and aching. Severe and acute. Symmetry. Well marked. Not usually present. Deposit of urate of Absent. Present. soda. DISEASES OF JOINTS 60 1 The Prognosis is usually unfavourable. The fact that many joints are affected is an indication that there is a considerable constitutional tendency to the development of the disease, and although it may be temporarily combated with success, still, sooner or later, the patient is almost certain to be crippled by it. The affection of only one joint often points to a traumatic origin, and the outlook is correspondingly brighter ; but where the disease attacks several parts of the body, there is but little hope of checking it, and indeed cases are known in which every joint has successively become implicated, the patient dragging on a weary existence, never free from pain, and usually in a cramped or sitting posture, until death from exhaustion supervenes. Treatment. — For this troublesome complaint there is, unfor- tunately, little that can be effected in the way of cure, although much can be done to alleviate. Locally, the articulations should be protected from cold and injury by being swathed in flannel, whilst stimulating embrocations and sedative applications may be beneficially employed. It is not advisable to maintain the joints absolutely and always at rest, otherwise they tend to become fixed, and their mobility is seriously limited at an unnecessarily early date. Moreover, it is often found that the more a joint is moved, the easier and less painful do those movements become, and hence regular massage is desirable. As to general treat- ment, the individual is warned against exposing himself to cold and damp, and, since the disease is often considered to be due to perverted or diminished nervous activity, all possible sources of irritation and w T orry should be removed. At the same time the nutrition must be improved, and plenty of good food, cod-liver oil, etc., administered. A large number of different drugs have been tried for this complaint, but none of them are very satis- factory. Perhaps the best is iodide of sodium combined with some alkaline purgative and hepatic stimulant, such as sulphate of soda. Natural mineral waters and baths are often beneficial, those of Bath and Buxton in this country being most frequently recommended. Arsenic is sometimes useful in cases where the disease is probably of nervous origin. Occasionally operative treatment in the shape of excision may be useful in this complaint, but only when the disease is limited to one joint, and when it has progressed to such a stage as to seriously cripple the patient's usefulness, as in the knee-joint, elbow or the shoulder, or when the act of mastication is impaired, owing to an affection of the temporo-maxillary articulation. In suitable cases excellent results are obtained. The hip-joint is not uncommonly the seat of osteo-arthritis in old people, and it always causes a considerable amount of pain, especially on flexion of the limb, rendering sitting difficult and walking uncomfortable, whilst the movements are steadily more 602 A MANUAL OF SURGERY and more curtailed. The limb appears at first to be slightly- increased in length, but later on becomes shortened from erosion of the head and atrophy of the neck of the bone ; the trochanter is also much thickened and more prominent than usual, on account of the associated atrophy of neighbouring muscles. Well-marked crepitus is obtained on moving the thigh. The acetabular cavity is increased in size owing to the formation of a projecting rim or lip. If a patient falls on the affected hip, some difficulty may be experienced in making a diagnosis from fracture of the neck of the thigh-bone. The previous history and the facts that the trochanter rotates around its normal centre, and is unduly prominent rather than approximated to the median line, and that the ilio-tibial band is not relaxed, as in fractures, should suffice to prevent mistakes. When the temporo -maxillary joint is affected, the condyle of the jaw becomes larger than usual and somewhat flattened, whilst the eminentia articularis is partially absorbed and the glenoid cavity increased in size, so that there is a tendency for the condyle to slip forwards owing to the action of the external pterygoid muscles. If only one joint is affected, the bone is carried towards the sound side, but when both are involved the chin becomes prominent owing to a forward displacement of the whole bone. Pain and crepitus are experienced on opening the mouth, rendering mastication difficult, and even impracticable. If ordinary treatment fails to give relief, the affected condyle of the jaw should be excised. For osteo-arthritis of the Spine, see Chapter XXII. Neuropathic Arthritis (Syn. : Charcot's Disease). This disease, bearing the name of the late Professor Charcot, is a peculiar affection of joints met with in the course of locomotor ataxy. It is slightly more common in women than men, and is almost always an early manifestation, occurring usually between the lightning-like pains and the onset of the ataxic symptoms. The most typical form is lighted up by some slight injury — e.g., a strain or sprain — and is characterized by a rapid painless dis- tension of the joint with a light-coloured serum, which may also extend into the communicating bursa? ; there is some amount of effusion into the surrounding cellular tissue, although without oedema. This distension may be so rapid that abnormal mobility or even dislocation may occur at the end of a few hours. The joints most frequently affected are the knee, hip, and shoulder ; occasionally more than one articulation is involved. The course of the case varies ; in some few instances the fluid is gradually absorbed and the joint returns to its normal size and shape, although somewhat weakened. Sometimes the attacks of dis- tension recur, and after each the joint becomes more and more crippled. In others, however, and perhaps most frequently, the DISEASES OF JOINTS b03 bones become eroded to a considerable extent, the ligaments stretched, and a weak, flail-like articulation remains, in which the ends of the bones are atrophied and displaced (Figs. 217 and 218). In other instances new osseous formations occur here and there under the synovial membrane, especially in cases where there is much distension, so that on compressing the swelling between the hands a sensation is produced similar to that im- parted by grasping a bag of bo.ies. Occasionally, under these Fig. 216. — Hypertrophic Variety of Charcot's Disease of Knee Joint. (From College of Surgeons' Mu- seum.) The patella (pat.) can be seen poised on the top of a mass of new bone formed by the welding together of a number of smaller portions formed in the peri- synovial tissues. Fig. 217. — Atrophic Variety of Charcot's Disease of Knee Joint. (From College of Surgeons' Museum.) The bones are cleanly eroded, and no new formation is present. The patella is reduced to a mere shell, one eighth of an inch thick. circumstances, the osseous masses become welded together, giving rise to large overgrowths, which lead subsequently to fixation of the joint (Fig. 216). The disease sometimes runs a more chronic course, and then closely resembles osteo-arthritis, since there is but little effusion, whilst the ends of the bones become eroded, and osteophytes, perhaps of great size, form around the edges of the cartilages, leading to defective mobility and crepitus. The Diagnosis of Charcot's disease from osteo-arthritis is, as a rule, readily made if one remembers the following points : Charcot's 604 A MANUAL OF SURGERY disease is usually characterized by a rapid onset, limitation to one joint, considerable effusion, absence of pain, atrophy of the ends of the bones, and a tendency to the production of a weak, flail-like joint, whilst the general signs of tabes are also observed. Osteo- arthritis, on the other hand, comes on slowly, often affects many joints, has but little effusion, is very painful, and is attended with overgrowth tending to produce ankylosis. In the more chronic cases the distinguishing features are much less evident. As to pathological anatomy, the changes observed are prac- tically identical with those seen in osteo-arthritis, except that the erosion is more rapid, the effusion greater, and the formation of osteophytes less constant. The Treatment of Charcot's disease consists in keeping the Fig. 218. — Charcot's Disease of Left Knee and Shoulder The great atrophy of the ends of the bones, and the resulting dislocations, are clearly evident. limb at rest on a splint and applying elastic pressure. The effusion, when considerable, may be removed by an aspirator, but is very likely to re-collect. In the later stages, where the joint is entirely disorganized, some form of fixed apparatus may be applied to render the limb more useful, or, failing that, amputation may be required. The same type of articular lesion occurs in Syringomyelia, a disease which consists in a gliomatous development in the spinal cord, and usually in the cervico-dorsal region. It is characterized by loss of the senses of pain, and of heat or cold, but tactile and muscular sensibility persists. Atrophy of various muscles of the hand or forearm also occurs, whilst trophic lesions, e.g., whitlow, perforating ulcer, etc., are common. Joint troubles are observed in at least one-third of the cases, mainly in the upper extremity, tabes generally affecting the lower. Either atrophic or hypertrophic phenomena are developed, and the course is identical with that of Charcot's disease, except that suppuration is a little more likely to follow, owing to the frequent presence of septic sores. i Somewhat similar in nature to Charcot's disease is the chronic arthritis met with in many conditions where the nervous supply to a limb is impaired as a result of central or peripheral disease of the nervous system. Thus, it may follow spina bifida, hemi- or para-plegia of cerebral or spinal origin, or may DISEASES OF JOINTS 605 be secondary to a peripheral neuritis, due to either injury, syphilis, gout, diabetes, leprosy, etc The terminal articulations of fingers or toes are those most often affected (acro-arthritis), although larger joints may be involved. They become swollen and painful, and after a time ankylosis ensues. Haemophilic Diseases of Joints. In haemophilia (p. 245) any injury to a joint, such as a sprain or wrench, may lead to a copious effusion of blood into the articular cavity, which becomes suddenly swollen, distended, and evidently full of fluid. There is some pain on movement, the part becoming hot and tender, whilst when coagulation has taken place it is hard and firm. Total recovery may ensue, or the joint be left weak and liable to recurrence of haemorrhage and inflammation. The effects on the articular surfaces are curious : the cartilages usually retain their normal colour, but become thin, worn, and rough, especially at the points of greatest pressure ; fibrillar degeneration of the matrix may occur, and in some cases the cartilage has been found totally absent, being replaced by fibrous tissue. Ecchondroses subsequently developing into bone are formed at the margins of the joint surfaces, the changes thus produced being somewhat akin to those of osteo-arthritis. The ligaments and synovial membranes may remain of a normal texture, or are slightly thickened, and usually of a russet-brown colour. Adhesions are often present, causing considerable impair- ment of mobility. The treatment consists in keeping the part at rest, and applying ice in the early stages ; whilst, later on, friction, massage, and pressure may be employed. The surgeon must never attempt to aspirate the joint, even with a fine needle. Loose Bodies in Joints. Several varieties of loose bodies are met with in joints, which may be described as follows : (1) The so-called 'melon-seed bodies' consist of dense fibroid tissue derived from altered blood-clot, or more frequently from a fibrinous exudation in cases of very chronic tuberculous disease. At first irregular in shape and laminated in texture, they are generally transformed into round pellets or elongated masses by the movements of the articulation. Bursas and tendon sheaths are much more frequently affected than joints. The number present is usually considerable, whilst there is also some glairy effusion, causing distension and a certain amount of creaking. A few years ago we operated on a case in which the knee-joint was occupied by a number of rounded yellowish-white foreign bodies, several of which were nearly as large as walnuts ; they were probably of haemorrhagic origin. (2) Portions of articular or interarticular cartilage may be broken off as a result of mechanical violence. They usually consist of a smooth rounded mass of articular cartilage enclosing a central bony nucleus (Fig. 219). (3) They are sometimes derived from the develop- 606 A MANUAL OF SURGERY ment of cartilaginous nodules in the synovial fringes or villi, which may either remain adherent and become pedunculated, then occasionally wearing a bed for themselves in the articular surface, or may be totally detached. Such structures are usually lobu- lated and irregular in shape, and consist of calcified cartilage or bone, whilst a certain amount of normal cartilage is also present (Fig. 220). It is not at all uncommon for this condition to be met with in osteo-arthritis, but sometimes the cartilaginous cells from which they are derived have persisted as a ' fcetal residue' owing to some modification in development. (4) Finally, portions of bone may become separated from their surroundings, and remain loose in the cavity. Thus, ecchondroses may be broken off in cases of osteo-arthritis, or portions of the articular surface detached by mechanical means, or even sclerosed areas isolated by a process Fig. 219. — Foreign Body in Joint, probably derived from a Portion of Articular Cartilage. (From College of Surgeons' Museum.) A, cartilage ; B, bone. of rarefying osteitis without suppuration, constituting what Paget originally described as ' quiet necrosis.' Although cut off from all vascular supply, the growth of some of these loose bodies is said to continue, owing to the highly nutritious fluid which bathes their surfaces. The Symptoms caused by this condition are produced by the loose body being occasionally caught between the articular surfaces, leading to a temporary locking of the joint and severe pain, owing to the stretching of the ligaments. The fixation is but momentary, since the foreign body is readily displaced, but an attack of subacute synovitis follows. When this has happened several times, the ligaments are likely to become relaxed, and the joint somewhat loose and distended. Under such circum- stances it may be possible to feel the foreign body and to shift its position, but frequently the surgeon, owing to its ready mobility, is unable to detect the intruder as it slips away into the interior of the joint. From this point of view, the German term 'Gelenkmaus' (joint mouse), as applied to this affection, is most DISEASES OF JOINTS 607 happy. The knee-joint is that most frequently affected, but the same condition occurs in the elbow and temporo - maxillary articulation. The Diagnosis between a loose body and a displaced semilunar cartilage in the knee-joint is not always easy, since in both con- ditions painful locking of the joint occurs. The fixation, however, is but momentary in the case of a loose body, but may persist until reduced in the latter, whilst a localized spot of tenderness may be detected corresponding to the site of the injury to the interarticular cartilage. Moreover, the history of the case is very different, since the dislocation of a semilunar cartilage is always primarily referred to some twist or sprain of the joint, whereas with a loose body no such traumatic influence need be present. Fig. 220. — Loose Cartilage in Joint, probably developed in a Fringe of Synovial Membrane. (From College of Surgeons' Museum.) A, cartilage ; B, bone. The Treatment consists in the removal of the foreign body. In former days this was done by means of various subcutaneous operations which it is unnecessary to describe here, since at the present time removal by the open method is always practised. In the knee-joint a vertical incision should be made, about 2 inches in length, extending a little above and below the line of the articula- tion. It should be placed about 1 inch from the patella, on which- ever side the loose cartilage presents most frequently, but prefer- ably on the outer. If possible, the foreign body should be fixed by the finger in one of the lateral pouches of the joint before making the incision. •¥ The capsule and synovial membrane are opened, the loose body removed, and the cavity washed out, if thought desirable, with sterilized saline solution. The wounds in the 6o8 A MANUAL OF SURGERY synovial membrane, capsule, and skin are then carefully sutured. The joint should be kept at rest subsequently for two or three weeks, and an elastic knee-cap worn for some time. Neuralgic Joints. In neurotic individuals, especially young women, a neuralgic condition of the joints is commonly met with, simulating disease of the articulation. On careful examination the pain is found to be superficial, not increased by jarring the articular surfaces together, and often not strictly confined to the joint. The movements are apparently limited, but if the attention of the individual is diverted, or anaesthesia induced, they are found to be perfectly free. There are no signs of effusion into the cavity, and no starting pains at night. Occasionally a similar condition is met with in men, where there is no suspicion of hysteria. The treatment is constitutional and local. The former is directed towards improving the general health, and correcting any error in the uterine functions. The latter is best accomplished by the use of cold douches and electricity, although counter-irritation in the shape of blisters, or even the actual cautery, has an excellent moral effect. Ankylosis. By ankylosis is meant a condition of immobility, partial or complete, of a joint, resulting from some preceding inflammation of the articular structures. The term false ankylosis is sometimes applied to a condition resulting from extra-articular lesions. Such may be either fibrous or osseous, and is due to cicatricial contraction of the skin, shortening of muscles, or even to the development of bony tissue within them (myositis ossificans). True ankylosis always involves the articular structures, and is either fibrous or bony. Fibrous or incomplete ankylosis results (a) from thickening and contraction of the ligaments, such as often occurs after gonorrhceal or rheumatic affections ; (b) from the formation of cord- or band- like adhesions within the joint, after acute synovitis ; (c) from erosion of the cartilage and exposure of the bone ; granulations sprout up on each side, and by their union lead to dense fibroid adhesions between the articular surfaces. Some amount of move- ment is possible in most of these cases. Complete or osseous ankylosis (synostosis) arises from the union of either the whole or part of the opposing surfaces left by the destruction of the cartilage, the bond of union, at first fibro- cicatricial, being subsequently ossified (Fig. 221) ; it may also be due to the interlocking and fusion of osteophytes, formed at the margin of the bone in osteo-arthritis or Charcot's disease. DISEASES OF JOINTS 609 The Causes of ankylosis are very variable, but may be arranged as follows : 1. Injury to the articular surfaces, as from fractures which run into a joint. 2. Non - suppurative inflamma- tions of joints, involving the for- mation of fibrous adhesions or the contraction of ligaments, as in synovitis, whether traumatic, rheu- matic, gouty, gonorrhceal, etc., and the early stages of acute or tuber- culous arthritis. 3. Destruction of bones, asso- ciated or not with articular diseases, as in Pott's disease of the spine, and the later suppurating stages of acute or tuberculous arthritis. 4. Nervous affections are occa- sionally the cause of ankylosis, by leading to a chronic form of arthritis. The lesions may be central, as in spina bifida, tabes and syringomyelia ; or peripheral, as in neuritis, Raynaud's disease, diabetes, leprosy, or division of nerves. 5. Long - continued abnormal pressure of contiguous bones may result in ankylosis, as in scoliosis or osteoarthritis of the spine. In the latter affection the immobility may be due either to ossification of ligaments or to the interlocking of osteophytes. The position in which ankylosis occurs and the effects thus pro- duced differ according to the joint affected. In the shoulder there is but little displacement, and the existence of immobility is of comparatively little importance, owing to the free movements of the scapula and clavicle. The elbow-joint is very commonly ankylosed on account of its exposed position, and the frequency of fracture-dislocations in its neighbourhood. The formation of callus, and the adhesions likely to form within the joint in these cases, readily explain its frequency. The most favourable position for ankylosis is when the arm is flexed to a little more than a right angle, with the hand midway between pronation and supination. By this means access to the mouth is possible, and the patient can use his hand for feeding purposes. The -wrist is most commonly fixed as a result of gonorrhceal or rheumatic synovitis. In the hip-joint (Fig. 221) much depends upon^the treatment as to whether the ankylosis takes place in a 39 Fig. 221. — Ankylosis of Hip- joint in Good Position after Early Hip Disease. (Howard Marsh.) 6io A MANUAL OF SURGERY good or bad position. In neglected cases the thigh may be in a position of adduction and internal rotation, crossing in front of the other leg. Occasionally a scissor-like deformity has resulted from inflammation of both hip-joints, one leg lying in front of the other ; progression is accomplished with difficulty, the body twisting at each step, and crutches are often needed. In the knee- joint ankylosis in an absolutely straight position of the limb should not be aimed at, since slight flexion renders the leg more useful both in walking, mounting stairs, and sitting down. In the ankle- ioint considerable trouble may arise from immobility, unless the foot is at right angles to the leg. Treatment. — Fibrous ankylosis may be treated by forcible, though judicious, manipulation of the limb under an anaes- thetic, thereby rupturing adhesions ; the limb is kept at rest for a few days, and then massage and passive movements are employed. If massive adhesions are present, but little good as regards mobility results from such treatment, since even if ruptured by the manipulations, they are almost certain to reunite ; in tuberculous cases it is unwise to attempt this for fear of diffusing or again lighting up the disease. It must not be forgotten that marked atrophy of bone is often associated with this condition, and therefore a fracture can easily be produced. For osseous ankylosis various operative measures may be employed, with a view either to correct the deformity, or in other cases to restore movement to the part. At the shoulder, wrist and ankle nothing need be undertaken unless obvious and troublesome deformity is present. At the elbow excision may be beneficially employed, and with every prospect of gaining a moveable joint. If, however, ankylosis is present in a child, the operation should be deferred until growth has come to an end. Ankylosis of the knee in a false position needs cuneiform osteotomy, or the resection of a wedge-shaped portion of bone, in order to secure a straight, rigid and useful limb. Ankylosis of the hip-joint in a bad position is best treated by dividing the neck or the upper part of the shaft of the femur. Several operations have been devised for this purpose : i. Adams' subcutaneous osteotomy of the neck of the bone consists in passing a sharp-pointed bistoury down to the anterior surface of the cervix femoris, from a point midway between the trochanter and the anterior superior spine of the ilium. A track is thus made, allowing the introduction of an Adams' osteotomy saw, by means of which the neck of the femur is divided subcutaneously. The limb is put up in a straight position, and the bone allowed to reunite. 2. The same result may be obtained by an open method, making the same incision as in the anterior operation for excising the joint (p. 624). Gant suggested division below the lesser trochanter. This may be accomplished by cutting down on the bone from the outer side and chiselling it across. DISEASES OF JOINTS 611 As to the operation to select in any particular case, the surgeon's choice must be guided by the condition of affairs present. A skiagram of the neck of the femur should always be taken so as to ascertain its condition. Sometimes it is stunted, and has practically disappeared ; in other cases it is much thickened, and forms a large bony mass passing from the trochanter to the ilium, and probably containing encapsuled foci of tuberculous material. In both these conditions subtrochanteric osteotomy must be employed, and it is not unusual to find that the adductor muscles are so contracted, that their attachments to the pubes require section before the limb can be satisfactorily straightened. Division of the cervix can only be recommended when that structure is of normal length and size. Hip-joint Disease. Although the term ' hip-joint disease ' is usually applied to a tuberculous arthritis, it is not the only affection involving this Fig. 222. — Tuberculous Disease of the Head and Neck of the Femur, showing Sequestra in an Abscess Cavity, and Communication on the Under Side of the Neck with the Joint. (Tillmanns.) The epiphysis of the head has been invaded, and the articular 'cartilage entirely stripped off by the disease; the continuous black line "indicates the amount of bone which it would be necessary to remove. articulation. Simple synovitis occurs in the course of rheumatic, gonorrhoeal, or pyaemic affections. Acute arthritis is also met with secondary to an acute infective osteomyelitis of the upper end of the femur, and is evidenced by all the ordinary signs of that affection, separation and necrosis of the upper epiphysis being a frequent result. Osteo-arthritis is not uncommon (p. 601), whilst Charcot's disease may also occur ; but none of these call for special mention here. Tuberculous Disease of the Hip (Syn. : Morbus Coxae, Tuberculous Coxitis, Coxalgia) differs in no respect from the same disease as it 39—2 6l2 A MANUAL OF SURGERY affects other joints, and hence no detailed notice of the pathological anatomy is required. Suffice it to say that it may originate in the synovial membrane or bone, more frequently in the latter, and then commencing either beneath the articular cartilage or in connection with the epiphyseal cartilage of the caput femoris (Fig. 222). Very rarely the disease becomes circumscribed in the neck of the bone, forming a chronic abscess, the diagnosis of which is exceedingly difficult. More usually the disease spreads to the under side of the neck, and thus involves the synovial membrane, which passes into a state of pulpy degeneration. The ■ .^ ' : '*''- Fig. 223. — Femur and Acetabulum in Hip Disease. (King's College Museum.) The epiphysis of the caput femoris has been practically destroyed, and the acetabulum is enlarged by absorption of its posterior margin, and dis- placed upwards [travelling acetabulum). The rami of the ischium and pubes have been removed. substance of the epiphysis is invaded, and caries of the head is thereby produced, together with necrosis or ulceration of the cartilage. The acetabulum undergoes similar changes ; from the contact and backward pressure of the diseased head the posterior acetabular margin is absorbed and the cavity extended, whilst at the same time a new rim of bone forms beneath the adjacent periosteum at a slightly higher level, thus giving rise to what is known as a ' travelling acetabulum' (Fig/ 223). In this way the socket is increased both in size and depth, travelling DISEASES OF J 01 NTS 6i3 backwards and upwards with the head of the bone towards the dorsum ilii. Other factors assisting in the displacement of the head of the bone are : the tonic action of the muscles, keeping the limb in a position of flexion, adduction, and inversion, thereby causing a considerable portion of the head to project out of the acetabulum ; and the early softening and destruction of the pos- terior ligaments, which are much thinner than those in front of the joint. Occasionally a mass of protuberant granulations sprouts up from the centre of the cavity, and may also assist in this process. Should the acetabulum be perforated, a tuberculous abscess is likely to form within the pelvis. The adjacent pelvic bones may A B CD Fig. 224. — Diagram to Illustrate the Positions assumed by the Limb in the Early and Late Stages of Hip Disease. A represents the position of abduction taken by the right limb in the early stage of hip disease, and B, Nature's method of masking this by tilting the pelvis down on the affected side, whilst the other leg is adducted; the effect of this on the spine, in causing a lateral deflection, is also indicated. C shows the same thing in the later stage, when adduction is present, and the pelvis is tilted upwards on the affected side, thus producing apparent shortening (D). either become thickened by the deposit of osteophytes, or carious ; if sepsis is present, necrosis may also supervene. Clinical History. — The patient, usually a child, is observed to limp, and may complain of pain either in the hip or inner side of the knee, the latter being due to the fact that both joints are supplied by the same nerves, viz., the anterior crural, sciatic, and obturator trunks. There may be some history of injury, but not necessarily. On examining the limb in the early stage, it is usually found to be apparently lengthened, whilst the thigh is slightly wasted. The nates are flattened, and the gluteal fold lost, conditions partly due to atrophy of the muscles, partly to the flexion of the limb. The joint is more or less rigid, and pain is produced on attempting to move it, or on jarring the leg, as by striking the heel or trochanter. The position assumed in this 614 A MANUAL OF SURGERY early stage is one of slight and increasing flexion, abduction, and eversion (Fig. 224, A), the reason for this being that thereby the ligaments, and especially the ilio-femoral, are most relaxed, and the capacity of the joint is at its greatest. The latter fact has been demonstrated in the healthy cadaver by inserting the nozzle of a syringe into the joint through the acetabulum, and forcibly injecting fluid, when this position is at once assumed. The flexion and abduction, however, are not always evident, since the flexion is masked by lordosis of the spine (Figs. 225, 226), and the abduction by the pelvis being tilted down on the affected side, producing thereby apparent lengthening of the diseased limb and lateral curvature of the spine, with its lumbar convexity Fig. 225. — Hip Disease, with Well-Marked Compensatory Lordosis, caused by Extending the Legs Flat on the Table. Fig. 226. — On Flattening the Spine against the Couch by raising the Unaffected Left Leg and pressing it up against the Abdomen, the Degree of Flexion of the Right Thigh at once becomes Obvious. towards the affected side (Fig. 224, B). The sound leg being brought into a position of adduction, the parallelism of the limbs is maintained. The flexion can be demonstrated by any method which obliterates the lumbar curve of the spine, as by fully bending up the sound limb on the abdomen, the affected thigh rising at once from the bed and forming an angle which indicates the amount of flexion (Fig. 226). The abduction is demonstrated by laying a rod across the two anterior superior spines, and placing another at right angles to its centre. This will not correspond with the line of the body or of the limb, but makes an angle with it. The eversion cannot be masked. The rigidity is easily demonstrable in that all movements of the hip-joint are greatly limited ; thus if an attempt is made to bend the affected DISEASES OF JOINTS 615 thigh on the abdomen, the corresponding side of the pelvis is raised with it from the bed. As the disease progresses, and the bones become more exten- sively affected, the pain increases, with nocturnal startings, whilst abscesses form, and a certain amount of fever and constitutional disturbance is caused thereby. The position of the limb also changes ; for although the flexion is maintained and even in- creased, adduction and inversion are now associated with it. The pelvis is tilted up on the affected side (Fig. 224, C and D), causing appavcnt shortening, lateral curvature with a lumbar con- vexity to the sound side, and abduction of the healthy limb. No satisfactory cause for this position can be given, but it is usually attributed to the yielding of the posterior and outer part of the capsule, together with infiltration and weakening of the small external rotator muscles, allowing the adductors and internal rotators unopposed play. When an abscess has formed, the most usual situation for it to point is a little in front of and internal to the great trochanter, close to the insertion of the tensor fasciae femoris. It may reach that spot either from an opening in the anterior part of the capsule, coming thus to the surface along the line of least resistance, or it may burrow from the posterior portion of the capsule along the rotator muscles and superior gluteal nerve. Less frequently abscesses pass directly backwards to open in the gluteal region, or forwards along the pubo-femoral ligament, pointing on the inner side of the femoral vessels below Poupart's ligament. As a rare complication, the tuberculous process may extend to the bursa under the psoas tendon, which usually com- municates with the joint, leading to the formation of an abscess in the lower part of Scarpa's triangle, and occasionally a typical psoas abscess results from an extension upwards within the sheath of the muscle of a tuberculous infection from this bursa. An intra- pelvic abscess following perforation or disease of the acetabulum may either burrow upwards, and come to the surface on the inner side of the vessels above Poupart's ligament ; or it may gravitate downwards, and burst in the ischio-rectal fossa, close to the tuber ischii. The final stage of the disease is one of real shortening (Fig 227), due to erosion of the head of the bone and its displacement back- wards upon the dorsum ilii. The position assumed is one of increased flexion, adduction, and inversion ; whilst if septic sinuses persist, hectic fever and amyloid changes in the viscera are likely to follow. At any stage cure by ankylosis may be obtained ; but unless the abnormal position has been corrected by extension, deformity is almost certain to be present. The Diagnosis of hip disease appears to be a matter of con- siderable difficulty to some, if we may argue from the mistakes 6i6 A MANUAL OF SURGERY which commonly occur. The pain in the knee present in the early stages leads to its frequently being mistaken for disease of that articulation ; a very slight amount of care in the examination should prevent such an error. From disease of the opposite hip, it is recognised by the relative mobility of the thigh on the two sides. The diagnosis from sacw-iliac disease is given at p. 619. Spinal mischief may also be confounded with it, if a psoas abscess points at any of the ordinary situations in which sinuses form in connection with the hip-joint. The presence of spinal deformity and the ability to perform the test movement for hip disease A B Fig. 227.— Position- of the Limb in the Later Stages of Hip Disease. A shows more especially the adduction and inversion ; B, the flexion and compensatory lordosis. should readily enable the surgeon to make a correct diagnosis, but it must not be forgotten that the two conditions may co-exist. If the limb can be put into what is known as the tailor's position — that is, flexion to a right angle with marked abduction and aversion — one may be practically certain that hip disease is not present. An encapsuled abscess in the neck of the femur is a condition which it is very difficult to distinguish from true hip disease. A constant deep boring pain is complained of, which is increased by pressure over the neck, or by jarring the trochanter ; but if the limb is manipulated gently, it can be proved that the movements of the joint are not really impaired. The Prognosis of hip disease is by no means unfavourable if the PLATE XXIX. 5 3 w c - 3 - » DISEASES OF JOINTS 617 condition is properly treated. Of course, the patient is liable to develop acute tuberculosis or tuberculous disease elsewhere ; or, if abscesses are allowed to become septic, serious complications — such as pyaemia, sapraemia, hectic and amyloid disease — may ensue. Apart from these, however, no serious consequences affecting life need be feared, although the usefulness of the limb may be seriously crippled from shortening or ankylosis, especially if the latter occurs in a faulty position. The Treatment ot hip disease must be conducted along the same lines as for tuberculous lesions generally. In the early stages the limb is kept at rest by the application of a Liston's splint, or it may be placed between sandbags, and a weight and pulley attached. By this means not only is rest assured, but deformity is prevented. If the amount of flexion is slight, the limb may be allowed to lie on the bed in the horizontal posture ; this will possibly induce some compensatory lordosis, but as the muscular spasm relaxes, the curvature of the spine disappears. When, however, a considerable de- gree of flexion is present, extension must be made along the axis of the flexed limb, which is supported on pillows. It will be found that after a few days the flexion diminishes, and the limb will then gradually assume the horizontal position. Should this precaution not be adopted, the extension merely pro- duces lordosis, and the pain from intra-articular tension is increased thereby. The general health of the patient must at the same time be attended to, and cod-liver oil and syrup of the iodide of iron may be administered with benefit. When the more urgent symptoms have dis- appeared, a Thomas's hip-splint is applied, so as to enable the patient to get about (Fig. 228). This con- sists of a flat bar of malleable iron, about an inch and a half wide, ex- tending from the axilla to below the knee ; it is shaped so as to fit the varying curves of the body, and cross-pieces embrace the trunk at the level of the nipples, as also the thigh and the calf ; it is firmly bandaged to the body and limb. A patten is placed under the boot of the sound leg, and the patient allowed to get about on crutches. This apparatus should be worn for six months after all signs of active disease have disappeared. It Fig. 228. — Thomas's Hip- splint APPLIED. 6i8 A MANUAL OF SURGERY may also be employed in the earlier and more painful stages if it is at first bent so as to accommodate itself to the flexed position of the limb ; as the effect of the rest becomes evident in a diminution of muscular spasm, the splint can gradually be straightened out, so that at length the limb is fully extended. When abscesses form, they may be opened antiseptically and drained, or preferably tapped and injected with iodoform, the former precautions as to rest and constitutional treatment being still maintained. More extensive operative measures — such as excision of the head by the anterior method (p. 624) — are sometimes undertaken in the early stages to cut short the disease, especially when prolonged treatment is impracticable, as amongst the poor, or when the general health and constitutional powers are defective. The removal of the whole head necessarily involves the upper epiphysis, and hence defective growth of the femur results, as well as immediate shortening. For these reasons, as also because repair is possible in most cases without operation (when there is a certain amount of recuperative power and prolonged treatment is feasible), this proceeding, at one time so common, is being dis- carded more and more in favour of conservative measures. It is sometimes possible, however, to save some portion of the head, and if so, this should always be attempted. A very success- ful series of cases has recently been published, in which the joint was opened from the front, the interior freely curetted (in one case after a temporary dislocation of the head), the bone scraped, and in more than one case a channel gouged along its anterior wall to expose and remove a deep focus. Indeed, when one attempts to save the head of the femur in this way, it is always well to remove the compact tissue from the front of the neck so as to expose and explore the epiphyseal line. By this plan, shortening and defective growth can to a large extent be avoided. In the later stages, and especially where sinuses have formed in the gluteal region or behind the trochanter, excision by the posterior method (p. 625) is preferable ; this is usually an easy matter since the head is probably eroded and displaced. The sinuses should, if possible, be included in the incision, but under any cir- cumstances must be opened up and scraped. When the aceta- bulum is extensively implicated, the disease can only be satisfac- torily dealt with by removing the head of the bone, and the posterior method affords the best means of subsequent drainage ; of course this presumes that the general condition of the patient has not been seriously undermined, and that there is a good pros- pect of gaining a useful limb. Otherwise amputation through the hip-joint is required, especially when the mischief has extended into the pelvis, or when, after excision, a weak, flail-like limb results or osteomyelitis supervenes. It is also needed when after excision sinuses persist and lead down into the acetabular cavity, from which there is a plentiful secretion of pus, and over the DISEASES OF JOINTS 619 entrance to which the upper end of the femur is drawn, thereby obstructing the escape of the discharge, and rendering dressing both difficult and painful. The operation often gives most excellent results, the patient's condition rapidly improving. Removal by the anterior racquet method is perhaps the most convenient. Disease of the Sacro-iliac Joint. Tuberculous disease of this joint is most commonly met with in adults, but rarely in children. It may commence in the synovial membrane, but is frequently the result of mischief starting in the pelvic bones, especially the ilium. The Pathological Anatomy calls for no description, inasmuch as it follows the ordinary course of tuberculous disease. The Clinical Signs consist of pain and a sense of weakness in the lower part of the back, increased by standing, walking, or any movement — such as coughing, sneezing, and the like — which calls the flat abdominal muscles into sudden action and drags on the ilium. It is of a very unpleasant character, a sensation as if the pelvis were coming to pieces being experienced by the un- fortunate individual. Owing to the fact that the lumbo-sacral cord passes in front of the articulation, pain is often referred to the gluteal region or down the leg. Movements of the limb cause pain if the pelvis is not supported, but can be freely performed if the pelvis is steadied. Compression together of the innominate bones, or their forcible separation, is the means of most effectually demonstrating the existence and situation of the pain. The patient is unable to stand or to put any weight on the affected limb, and hence limps during walking, allowing his body to lean forwards, and making use of a stick. There is apparent lengthen- ing on the affected side, but on measurement from the anterior superior spine to the internal malleolus the leg is found to be of the same length as its fellow. This appearance is due to the fact that the whole innominate bone is tilted downwards and forwards, so that the anterior superior spine is at a lower level and more prominent than that on the opposite side. The region of the synchondrosis is often swollen, puffy, and tender ; whilst after a time abscesses form, which may either point immediately over the articulation, or burrow upwards into the lumbar region, or forwards into the groin, or downwards into the pelvis, opening in the ischio-rectal fossa. The last is a most serious complication, since it necessarily introduces the septic element. The Diagnosis needs to be made from sciatica, hip disease, and spinal disease. Sciatica is known by the character of the pain, which shoots down the back of the thigh in the course of the great sciatic nerve, which may be distinctly tender on pressure. There is no apparent elongation of the limb, and compression together of the pelvic crests is painless. From affections of the hip-joint, 6ao A MANUAL OF SURGERY sacro-iliac disease is recognised by the fact that, if the pelvis is supported, the thigh may be moved in all directions without great discomfort ; whilst compression of the pelvis in hip disease causes no pain. Moreover, in the advanced stages of hip disease, there is apparent or real shortening, a condition never noticed in the sacro-iliac affection. From spinal disease, the diagnosis should not be difficult if a careful examination of the spine and pelvis is made. The Prognosis of sacro-iliac disease, though usually stated to be unfavourable, is not necessarily so if asepsis is maintained ; it is the admission of the septic element that constitutes the main danger. When affecting girls, it may lead to subsequent deformity of the pelvis and trouble in parturition. Treatment in the early stages consists in absolute rest, with the application of a pelvic support, and attention to the general health, combined possibly with local counter-irritation. When abscesses form, they should be freely opened, and if diseased bone can be felt with a probe, it should be scraped or cut away, and the parts swabbed over with pure carbolic acid. Occasionally it is necessary to remove the posterior part of the iliac crest in the neighbourhood of the posterior superior spine in order to gain access to the diseased area ; this may be accomplished by the chisel or trephine through a vertical incision, and we have had a number of excellent results from this proceeding. Excision of Joints. Excision of joints is an operation which, though formerly undertaken in a few isolated instances for compound fractures and dislocations, has only during the past fifty years been estab- lished on a scientific basis, or utilized to any great extent. The late Sir William Fergusson was one of the chief pioneers in this branch of operative surgery, and to his skill and insight we owe much of what has thus been gained. Since the introduction of antisepsis, however, the operations have been still further elabo- rated, and excision is now undertaken for many conditions that formerly would not have been so treated. The chief articular lesions for which excision, partial or complete, is now recom- mended are as follow : i, For compound dislocations or fracture- dislocations ; 2, for various forms of simple or comminuted fracture in the neighbourhood of joints where ankylosis is likely to follow, and either interfere seriously with the utility of the joint or fix it in a bad position ; the shoulder and elbow are the joints most frequently dealt with in this way; 3, for some forms of congenital or old-standing dislocation which cannot be other- wise remedied ; 4, in the later stages of acute arthritis, where the ends of the bones are carious, the joint disorganized, and chronic suppuration is present ; 5, in tuberculous arthritis, where DISEASES OF JOINTS 621 palliative treatment has failed to cut short the disease, or where disorganization of the joint has occurred with erosion of the ends of the bones ; 6, for ankylosis of certain joints, consecutive to arthritis, either acute, tuberculous, or syphilitic, especially if in a bad position ; 7, for osteo-arthritis in special regions. The results to be attained necessarily vary in the different joints, and according to the particular causes. Sometimes anky- losis in a good position is all that can be expected, in others a freely moveable pseudarthrosis ; in some cases the removal of certain diseased tissues is the primary object of the operation, whilst in others no disease is present. All these varying con- ditions must be taken into consideration in determining the nature and extent of any excision. The late Professor Oilier of Lyons emphasized and established the benefits to be derived from subperiosteal resections in certain cases. Necessarily, every excision must lead to consider- able interference with the peri-articular structures ; muscles and tendons have to be detached from their insertions, and portions of the bones removed. If, however, the periosteum is raised, together with the attached muscles and tendons, prior to sawing or cutting the bones away, a more satisfactory reproduction of the articular structures follows, and the movements of the joint suffer less interference than if one cuts away the periosteal envelope with the bone. Of course, where the periosteum is invaded with tubercle, this should not be attempted, whilst in some joints — such as the elbow — there is no advantage to be derived from it, since there is always a tendency to too great a formation of bone, and this would possibly be. exaggerated by a subperiosteal resec- tion. It is rather in the operations undertaken for traumatic lesions that this plan is to be recommended. In a small text-book like this we must perforce limit ourselves to a description of the methods most commonly adopted, and refer students to special works on Operative Surgery for further details. Shoulder-joint. — Excision of the shoulder-joint may be needed for tuber- culous disease, for the later stages of acute arthritis, occasionally for osteo- arthritis if the disease is limited to this articulation, for compound or com- minuted fractures, and possibly for simple fractures of the anatomical neck when associated with dislocation of the small detached head of the bone. In old unreduced dislocations where passive movement is impracticable, and there is little hope of improvement, excision may give excellent results. Operation. — The patient lies on the back, the shoulder projecting somewhat over the edge of the table, and with a sandbag beneath the scapula to steady it. The arm being slightly rotated inwards, an incision is made from a point midway between the coracoid process and the acromion, extending downwards and outwards for 3 or 4 inches through the fibres of the deltoid muscle (Fig. 229, D). It is better to incise the deltoid than to pass between it and the pectoralis major, the cephalic vein and accompanying artery being thus uninjured. The wound is thoroughly opened up by means of retractors, and the bicipital groove looked for ; an incision is made along its outer border, 622 A MANUAL OF SURGERY and the long tendon of the biceps, if still present, turned out, and held to the inner side by a blunt hook. A twig of the anterior circumflex artery will here be divided, and need a ligature. The arm is now thoroughly everted, and the tendon of the subscapularis and the anterior part of the capsule, with which it is incorporated, freely divided ; where practicable, the attachments of the muscle to the bone should be separated subperiosteally, a proceeding pre- senting no difficulty where inflammation has previously existed. The arm is now inverted and held downwards by the side of the table, so as to bring the great tuberosity into view ; the muscles attached to this process are dealt with in a similar way, and the upper part of the capsule freely opened. The head of the bone is then protruded into the wound, and removed by the saw. It will often suffice to apply the saw obliquely through the substance of the tuberosity ; this is to be preferred to removal of the whole tuberosity by a horizontal incision at a lower level. The synovial membrane and glenoid cavity are dealt with as circumstances may dictate, and it is often advisable to make a counter-opening through ths posterior axillary fold for the insertion Fig. 229. — Incision for Excision of Shoulder. A, coracoid process ; B, tip of acromion ; C, intermuscular line between deltoid and pectoralis major; D, incision. of a drainage-tube ; the anterior wound can then be entirely closed. In applying the dressing, care must be taken to put a good pad in the axilla, so as to keep the arm from being drawn forcibly inwards by the muscles attached to the bicipital groove. There is no need to commence passive movements before the end of the first week. Fibrous union usually results, and the move- ments of the shoulder are generally very good. Excision of the Elbow may be required for simple or compound fracture-dis- location, or for subsequent ankylosis, especially if the limb is in a bad position, for tuberculous arthritis, and possibly in the later stages of acute arthritis. The best plan of operating is as follows : A single longitudinal incision, 5 inches in length, is made in the middle line of the posterior aspect of the joint, extending for equal distances above and below the tip of the olecranon, and a little to the inner side The limb is held across the patient's body, the surgeon standing on the affected side. The incision extends through the DISEASES OF JOINTS 623 substance of the triceps down to the bone. The origin of the flexor carpi ulnaris and the inner half of the triceps tendon are detached, and the hollow- between the olecranon and the internal condyle cleared, the knife being kept close to the bone, and the soft parts retracted by a vigorous use of the thumb- nail. By this means the ulnar nerve escapes injury, and, indeed, is often not seen at all. The internal lateral ligament should be divided, and the common origin of the flexors from the front of the inner condyle. The outer half of the joint is then dealt with in a similar way, the anconeus being divided close to its insertion to the ulna, the continuity of the triceps with the deep fascia covering it being also maintained. The origin of the extensor muscles is separated from the back of the outer condyle, and the external lateral ligament severed. The joint can now be freely opened by dividing any of the fibres of the posterior ligament which remain intact, and the denuded ends of the bones protruded from the wound. The lower end of the humerus is now thoroughly cleared, and the articular surface removed, the section passing through the centre of the olecranon fossa. The olecranon, together with the upper articular surface of the coronoid process and the head of the radius, are next sawn off, care being taken to draw aside and protect the soft parts by retractors, especially those covering the ulnar nerve. The synovial membrane can be dealt with as may be necessary. Even if the head of the radius is free from disease, nothing is gained by leaving it intact, since ankylosis is very likely to follow unless plenty of bone is removed. For a similar reason sub- periosteal resection is needless, and, indeed, is an undesirable refinement. The wound is carefully sutured, and a drainage-tube inserted for a few hours. The limb is kept on a hinged angular splint for a week, by which time union of the external wound should be complete, but the position is altered each day. After a week, the splint may be dispensed with, and the limb kept at rest on a pillow, free passive movement, both angular and rotatory, being daily practised. Considerable attention is needed in order to obtain a good result, but in a successful case every movement of the joint is perfectly restored. As a rule, the lower end of the humerus develops two lateral bony processes, like malleoli, within the grasp of which the upper rounded ends of the radius and ulna are able to move. The Wrist-joint is only excised for extensive tuberculous disease when abscesses and sinuses are present. Ankylosis of the articulation, though a troublesome condition, is not sufficiently so to require such treatment. The best method to employ is that known as Lister's operation, a somewhat com- plicated proceeding, but which in suitable cases gives excellent results. Prior to operating the fingers are well bent, so as to break down any adhesions which are present. Two incisions are made, one on the radial side of the dorsum, and the other on the inner or ulnar aspect of the wrist. The dorsal incision is angular (Fig. 230, L, L), commencing at a point on the back of the radius between the tendons of the extensor secundi internodii pollicis (B) and the ex- tensor communis digitorum (D) ; it is at first parallel to the former tendon, and on its ulnar side, till it reaches the base of the second metacarpal bone, when its direction is changed, and it courses downwards along that bone for an inch or two. It should extend to the bone, and in doing so the tendons of the extensor carpi radialis longior and brevior (H and I) are divided as close to their attachments as possible. The tendinous structures are then stripped off the back of the dorsum on either side of the incision, and on the outer side a pair of cutting pliers is insinuated so as to detach the trapezium from the rest of the carpus. The synovial sheaths of these tendons should, if possible, not be opened. The hand is then rolled over, and the ulnar incision made well on the inner side of the limb, extending for at least 3 inches between the extensor and flexor carpi ulnaris tendons. The separation of the extensor tendons from the back of the carpus is now completed, and the attachment of the extensor carpi ulnaris (K) divided. The tissues on the palmar aspect of the joint are detached, the pisiform being severed from the rest of the carpus, and where possible left, and the hook of the unciform clipped off with cutting pliers. The carpus is now free front and back, and 624 A MANUAL OF SURGERY the bones are either removed piecemeal or taken away en bloc by inserting a pair of cutting pliers above and below, and dividing their upper and lower connections ; more usually the carpal bones are picked out in fragments. Attention is then directed to the lower ends of the radius and ulna, and to the articular ends of the metacarpal bones, all the cartilage and the intervening synovial tissue being cleared away. Finally, the remaining fragments of the carpus are dealt with as the case may require. The radial incision may often be entirely closed, whilst a drainage-tube is inserted through the ulnar wound. The hand is placed on a special splint, with a thick convex cork support for the palm, which keeps the wrist slightly extended, and with a short lateral projection upon which the thumb can rest. The fingers must be thoroughly flexed and extended daily, beginning on the second or third day, but the wrist should be kept at rest until it is quite firm. There is a much greater tendency to a flail-like joint than to undue fixity, owing to the amount of bone removed, Fig. 230.— Excision of the Wrist. (Lister.) A, Radial artery ; B, extensor secundi internodii pollicis ; C, ext. indicis ; D, ext. communis digitorum ; E, ext. minimi digiti ; F, ext. primi inter- nodii pollicis ; G, ext. ossis metacarpi pollicis ; H, ext. carpi radialis longior ; I, ext. carpi radialis brevior ; K, ext. carpi ulnaris ; L,L, line of radial incision. and the necessary divisions cf all the extensors of the carpus ; if such occurs, a leather support must be worn, either as a temporary or permanent appliance. The Hip-joint is rarely excised for conditions other than tuberculous disease, and even for this it is performed much less frequently than formerly. There are two chief methods of operating, the anterior and the posterior. 1. Excision by the anterior method is carried out as follows: The incision (Fig. 75 D ; p. 292) extends from immediately below the anterior superior spine vertically downwards for 3 or 4 inches. It passes between the tensor fasciae femoris and sartorius muscles superficially, and between the glutei and rectus deeply, a small arterial twig from the external circumflex being divided at this stage. The neck of the bone and capsule of the joint are exposed, and the latter is freely incised along its attachment to the anterior intertrochanteric line, so as to allow of the admission of the finger, whereby the joint can be fully explored. The neck of the bone is cut through in situ by means of an Adams' osteotomy saw, the incision through the bone being placed obliquely DISEASES OF JOINTS M downwards and inwards. The head of the bone is now either prised out of the acetabulum by an elevator, or grasped by lion forceps and twisted out, a matter easily accomplished where the articular structures are diseased, but a proceeding of some difficulty in the normal joint of a cadaver. As much of the infected synovial membrane as possible is clipped away with scissors, and the acetabulum scraped, if necessary. The external wound is either closed, with the exception of an opening for a drainage-tube, or stuffed with gauze soaked in iodoform emulsion. There may be comparatively little shortening of the limb as the result of this proceeding, but the movements are considerably limited. 2. Excision by the posterior method, as we have already said, is usually undertaken in the later stages of the disease. Any sinuses which exist pos- teriorly may be utilized, but if the skin is unbroken, an incision known as Langenbeck's may be employed (Fig. 231). The patient lies on the sound limb, whilst the affected thigh is flexed. The incision is made in the line of the femur, extending 2 inches above the top of the great trochanter, and about 3 inches below it. It is carried at once down to the bone, and the muscles attached to the summit and posterior border of the great trochanter freely divided, as close to the bone as possible. The capsule is opened to a sufficient extent to allow of the exploration of the joint by the finger. If the disease is very extensive, the femur is now chiselled across, immediately below the great trochanter, but above the lesser. The upper end of the bone is grasped by lion forceps, and twisted out of the acetabulum, after division of the remaining structures, which are attached chiefly along its anterior border. The ligamentum teres has almost always been previously destroyed, and hence this stage of the operation is not especially difficult. The synovial membrane and acetabulum are easily reached, and the diseased portions removed. In favourable cases a drainage-tube may be inserted, and the wound closed, but not uncommonly it is wiser to partially stuff it with gauze infiltrated with iodoform, and allow it to heal by granulation. Slight extension of the limb should be sub- sequently made, so as to prevent undue shorten- ing from the traction of the long thigh muscles. The leg is placed between sandbags, or a Liston's long splint applied. Fibrous ankylosis, with a certain limited amount of movement, is the usual result. It is not always necessary to include the trochanter in this operation. If the disease is limited to the head of the bone, it alone should be removed, with as little disturbance as possible to the muscles passing to the trochanter. If such can be effected, the subsequent mobility and usefulness of the limb are considerably in- creased. The advantages claimed for the anterior method are : that it is a less severe operation, that fewer muscles and tendons are interfered cision for Excision of the with, that no vessels of importance are divided, Hip from Behind. (Till- and that only the head of the bone is excised. manns.) The objections to it are : that the drainage pro- vided is very unsatisfactory, that the trochantei cannot be readily dealt with, whilst it is also difficult to remove all the synovial membrane. The great advantages of the posterior operation are that, in spite of a free division of the muscular and tendinous attachments, excellent drainage is provided, and both trochanter and acetabulum are readily accessible. On the whole, the anterior method should be employed in the early stages of the 40 Fig. 231. — Langenbeck's In- 626 A MANUAL OF SURGERY disease, the posterior in the later. The situation of abscesses or sinuses may, however, determine the choice of the surgeon. The Knee-joint is excised for tuberculous disease, osteo-arthritis, or deformity due to osseous or fibrous ankylosis in a bad position. A horseshoe-shaped incision is made, extending from the back of one condyle to the other, reaching downwards nearly as far as the tubercle of the tibia. The limb is well flexed, the ligamentum patella? divided, and the joint opened. The skin and subcutaneous tissues are then separated from the anterior surface of the patella, which may be at once removed by a curved incision above it, communicating on either side with that already made below. The flexion is now increased, and the lateral ligaments divided ; by this means the interior of the joint is freely exposed, so that the attachments of the crucial ligaments to the tibia can also be severed. The lower end of the femur is then cleared of diseased synovial membrane, so as to allow of the application of a broad excision saw. The usual rule given as to the direction of the saw-cut in the bone is that the exposed bony surface left after removing its articular end should be absolutely horizontal, supposing the patient to be standing upright ; personally, we prefer to make the sections so that the limb shall be left very slightly flexed and in-kneed, a position which greatly adds to the subsequent comfort of the patient. To accomplish this, the saw must be applied parallel to the articular surface, i.e., at right angles to the axis of the body, not of the femur, and with a slight upward slant from before backwards. The bone should be partially sawn through by a side-to-side movement, but the posterior surface of the condyles should be divided by raising or depressing the handle of the instrument, so that the structures lying behind in the intercondyloid notch are not encroached upon. Sufficient bone should be sawn off in the adult to include the greater part of the articular cartilage, but as little as possible con- sistent with removing all the disease, otherwise the limb is shortened to such an extent as to interfere with its subsequent usefulness. The head of the tibia is then protruded, and cleared from the neighbouring soft parts; it is held absolutely vertical, and a saw applied in a horizontal position, the bone being divided from before backwards. Any diseased synovial membrane is now dissected away, special attention being directed to the subcrureal pouch. All bleeding-points having been secured by ligature, the bones are fitted together, and, if considered advisable, secured in position by thick silver wire, or silver- plated nails or screws. The external incision is closed, drainage-tubes being inserted at each angle of the wound. A Gooch's splint is applied to the limb, and in this it remains until sound healing has occurred, after which an im- moveable case either of plaster of Paris or water-glass is kept on until eight or ten weeks have elapsed since the operation. The Ankle-joint is excised for tuberculous disease. Two incisions are made, an inner and an outer. The outer incision runs along the anterior border of the fibula and curves round the outer malleolus, being about 3 inches in length. The lower end of the fibula is exposed, and by preference subperiosteally. The external lateral ligament is split vertically, and separated from its attach- ments to the fibula, its continuity with the periosteum being, however, main- tained. The fibula is then divided about 1 inch above the tip of the malleolus, and the latter process of bone removed. The periosteum and ligaments are separated as far as possible from the front and back of the bones. The inner incision is T-shaped, and is made along the inner surface of the tibia, with a short transverse cut at its lower end, which reaches just below the inner malleolus. The periosteum and internal lateral ligament are dealt with as on the outer side, and the front and back of the tibia are easily denuded. The inner malleolus is projected from the wound, and the lower end of the tibia removed by a keyhole saw, the dorsal structures being held aside by a retractor. The articular surface of the astragalus is sawn off from the outer wound, or, if advisable, the whole of the bone may be removed. The above subperiosteal method of excision is one of the best that have been suggested. The greatest care should be taken not to open the sheaths of DISEASES OF JOINTS 627 the tendons, and in dressing the wound the foot must be kept at right angles to the leg, and no lateral deviation permitted. As soon as possible it is encased in plaster of Paris, windows being left for the dressing of the wounds, if necessary. In non-tuberculous cases a transverse incision extending from one malleolus to the other may be employed. Sutures are placed through the tendons above and below, and they are then divided ; the anterior tibial nerve is similarly secured above and below before division, and the vessels are divided between ligatures. By opening the capsule a very free exposure of the joint surfaces is provided, permitting a very thorough excision. The tendons and nerve are carefully sutured together before closing the wound. Excision of the Astragalus is sometimes required in the treatment of tuber- culous disease of contiguous joints, as also in some cases of talipes and of fractures or dislocations of the bone. Many methods of operating have been described, but we think it is best accomplished through a single vertical incision over the front of the ankle, running parallel to the vessels and tendons, which are carefully avoided and stripped back from the dorsum by means of periosteal detachers, so that the upper surface of the astragalus can readily be reached. The astragalo-scaphoid and ankle-joint are then freely opened, and the ligamentous and fascial connections on either side severed. The neck of the bone may with advantage be divided at this stage, and its head removed, so as to give access to the under surface and allow of the division of the strong interosseous ligament extending between the adjacent surfaces of the astragalus and os calcis. It may be possible to remove the rest of the bone in one frag- ment, but it is certainly wiser to break it up with chisel or gouge, and take it away piecemeal. 40- CHAPTER XXI. INJURIES OF THE SPINE. The spinal cord is protected from injury in a most complete and efficacious manner, (a) Its position between the bodies and the laminae with the spinous processes arising therefrom is itself mechanically advantageous, since, whether the spine is forcibly flexed or extended, the cord remains midway between the points of chief compression or extension, and hence in a position of rest. (b) The buffer-like action of the intervertebral discs, and the varying curves of the column, serve to distribute some part of any force that reaches it. (c) There is ample space in the medullary canal, in which the cord with its membranes is slung by prolongations of dura mater around the issuing nerves, whilst the cord itself hangs loosely within the dura mater, suspended by the ligamenta denticulata, and surrounded by cerebro-spinal fluid. (d) The cord terminates, in an adult, at the lower border of the first lumbar vertebra, a spot well above the junction of the fixed base and the moveable upper part, a point where the effect of jars and wrenches is mainly felt, (e) Nature has, moreover, intro- duced a whole series of buffers and other means of preventing shock to the spine when a person falls on his feet, e.g., the arches and elasticity of the foot, the changes in direction of the bones at each joint, the interarticular cartilages of the knee, etc. The parts of the spine most exposed to injury are those where a fixed and moveable portion meet, e.g., the dorsi-lumbar and the cervico-dorsal regions. The upper part of the dorsal curve, which is relatively weak and projects backwards, is thereby exposed to injury, so that fractures are not at all uncommon about the fourth dorsal vertebra. The close proximity of the head explains the frequency of lesions about the upper cervical region. Sprains. Sprains and strains of the spine are very common accidents, a fact not to be wondered at, when we consider the complicated INJURIES OF THE SPINE 629 muscular and ligamentous arrangements present. They are produced by any sudden or unexpected movements, such as falls, especially from horseback, railway accidents, and the like. The injury is most likely to affect mobile parts of the spine, e.g., the cervical and lumbar regions, and may be limited to the liga- mentous or muscular structures, or may involve both. The resulting Signs are simply those of a severe but localized trauma, viz., pain, tenderness, bruising, and perhaps a little swelling ; the subjective phenomena are much increased by movement, so that the spine is always kept rigidly quiet. If only the muscles or interspinous ligaments are involved, no further consequences are likely to arise ; but when the ligamenta subfiava are lacerated and the spinal canal is thus opened, the gravest symptoms may ensue from blood finding its way into the canal outside the dura mater, leading possibly to paraplegia, which may be of a tempo- rary or permanent nature. Inflammation of the damaged fibrous tissues may also extend to the meninges and cord, and cause compression of the latter or even organic disease. Moreover, in patients of a tuberculous temperament, spinal caries may be set up as a result of such injuries, whilst syphilitic or malignant disease has also been known to follow. In the cervical region, sprains are very liable to occur as a result of severe blows on the head, causing rupture of the inter-transverse ligaments, and the displacement may be so great as to simulate dislocation. The head and neck are held immoveable and rigid, and there is often considerable loss of power, the patient being sometimes unable to lift the head spontaneously from the pillow. Sprains in the lumbar region are very common, both as a result of railway injuries, when they are often associated with nervous symptoms (p. 640), and as a consequence of overlifting, when the quadratus lumborum is most likely to be affected. The back is kept fixed and rigid, the patient being unable to turn or stoop without pain. Sometimes hematuria results from injuries in the lumbar region, arising from an associated contusion of the kidneys. Treatment. — The patient should be kept at rest, and fomenta- tions applied to the injured part. When the painful or inflam- matory symptoms have disappeared, massage with stimulating liniments is needed. In the severer cases the individual should be kept in bed for six or eight weeks, and in the cervical region some form of mechanical support may be subsequently necessary. The appearance of inflammatory symptoms involving the meninges calls for greater care ; the patient should then be kept as much as possible in the prone position, and a spinal icebag applied. The onset of paraplegia, due either to haemorrhage or inflammatory exudation, would raise the question of laminectomy (p. 644). 6.30 A MANUAL OF SURGERY Penetrating Wounds of the Spine. These lesions are, fortunately, uncommon in civil practice, being generally due to stabs with pointed instruments, such as bayonets, or to gunshot wounds. They occasionally result from falls, the unfortunate individual becoming impaled on area railings, branches of trees, etc. The Symptoms produced are (a) those due to the wound in the soft parts, which may also involve the peritoneal and pleural cavities, or damage some of the viscera ; in the neck, the vertebral artery is exposed to injury from this type of accident, leading to serious haemorrhage ; (b) various forms of fracture, the cord being compressed by fragments of bone which have been driven inwards, or by extravasated blood ; (c) those due to laying open the spinal mem- branes, e.g., loss of cerebro-spinal fluid, which in itself might prove fatal by draining the cerebral cavity, and so causing pressure on the base of the brain, or at a later date may determine the patient's death by setting up diffuse septic meningitis (p. 638) ; and (d) those due to wounds of the spinal cord. The effects of a total transverse lesion at different levels of the spine are given at p. 643 ; even if the patient escapes the dangers of diffuse septic meningitis, he will later on develop acute myelitis. Of course, the division of the cord may be only partial, or it may escape entirely, whilst nerve roots or trunks may be involved, and in the lumbar or sacral regions the cauda equina may be divided. Treatment consists in thoroughly exploring the wound under an anaesthetic, removing foreign bodies or displaced fragments of bone, and attempting to render it aseptic. Wounds of the vertebral artery or other structures are dealt with secundum artem, and special attention is naturally given to the cord and its membranes. Should the dura mater have been opened, and the cord have escaped injury, an attempt may be made to close the wound in the meninges, and the patient should subsequently be kept in the prone position and with the head low, so as to prevent, as far as possible, the escape of cerebro-spinal fluid. If the cord itself is divided or lacerated, it is useless trying to unite it, since its function in conducting impulses from the brain downwards is inevitably destroyed. Where, however, the cauda equina has been injured, it is perfectly justifiable to lay open the spinal canal to a sufficient extent to expose the divided nerve trunks, and then to suture them. Fractures of the Spine. Causes. — The spine may be broken as the result of (a) direct violence, e.g., a fall on the back over some projecting body, such as a carpenter's bench or a railing, or a blow on the back with a heavy stone or with a swinging baulk of wood, or a gun- shot wound. This type of accident may involve any part of the spine, and, excluding those arising from gunshot, is less frequent INJURIES OF THE SPINE 631 than the class next to be described. Of necessity, the spine breaks at the point struck ; the posterior parts of the vertebra? are most likely to be damaged in this form of injury, (b) Fractures are also due to indirect violence, then usually occurring in the lower cervical or upper dorsal regions. They are caused by forcible flexion of the spine, as by a fall downstairs with the head doubled up, or by taking a ' header ' into shallow water, or when a man, being driven under a bridge, omits to stoop, and so is caught between the arch and the cart, or sometimes by the fall of a heavy weight on the back of the neck, the spine bending and breaking at the weakest spot. Fractures of the spine may be divided into two main classes, according to whether or not they are complete — that is, according to whether the continuity of the column is destroyed or not. (A) Incomplete Fractures may be met with in various forms, and are most frequently due to direct violence. (i.) Fractures of the Spinous Processes rarely occur except in the lower cervical or dorsal regions. In the upper cervical region the spines are short and retracted to allow of extension of the head, whilst in the lumbar they are also short, but very strong. The fracture is almost always due to direct violence, and is charac- terized by the signs of a local trauma, together with great mobility, perhaps crepitus, and irregularity in the line of the spines. The process is occasionally much depressed, and may even cause paraplegia by being driven into the spinal canal. (ii.) Fracture of the Lamina is a not uncommon accident, always resulting from direct violence. If only one lamina is broken, the signs are not very distinct, and cord symptoms are rare. When both laminae yield, the posterior part of the neural arch, carrying with it the spinous process, is very likely to be depressed to a sufficient extent to compress the cord and give rise to paraplegia. Crepitus is often obtainable, and a gap in the line of the spinous processes can usually be felt. (iii.) Fracture of the Transverse Processes is but rarely met with apart from other lesions of the spine. . (iv.) Partial Fracture through the bodies may occur in the form of fissures, which produce but little effect, except pain and rigidity, and cannot be diagnosed with certainty. Even in fractures where displacement is not present, paraplegic symptoms may arise, either immediately from concussion of the spinal cord, or later on from the pressure of haemorrhagic or inflammatory effusions. The Treatment merely consists in keeping the patient at rest for a time. The question of laminectomy for paraplegia, due either to displacement of the laminae or to haemorrhage, will be discussed later (p. 644). (B) Complete Fractures are usually associated with displace- ment, and loss of continuity of the spinal column, and hence 632 A MANUAL OF SURGERY are often termed Fracture-Dislocations. They result either from direct or indirect violence. There is always a tolerably extensive lesion (Fig. 232) ; thus, the spinous processes and laminae may or may not be fractured, the ligamenta interspinosa, snpraspinosa, and subnava torn, the articular processes fractured in the lumbar and dorsal regions, or displaced without fracture in the cervical, and either the intervertebral substance torn across, or the bodies broken, thus severing the spine into two halves. The upper or moveable portion is usually driven forwards over the lower or more fixed fragment, and im- paction or comminution is often present. The spinal cord is com- pressed between the upper end of the lower fragment and the la- minae of the upper fragment, and although the displacement may be naturally remedied by the falling back of the bones into position (' recoil '), yet the effects of the crush on the cord are usually irremedi- able. In slighter cases the spinal membranes may be merely punctured by a splinter of bone, or haemorrhage may occur either within the membranes, or outside them in the fatty theca vertebralis. Excessive indirect violence may lead to an associated fracture of the sternum. The Signs of a complete fracture are usually very evident, con- sisting of local pain, swelling, and bruising, and a certain amount of angular deformity, more or less according to circumstances. It may be possible to elicit crepitus, if the parts are not impacted, but all unnecessary movement should be avoided for fear of adding to the injury of the cord. Paraplegia below the part injured is present in most cases, and with it some amount of general shock. When the cord is disintegrated or divided, symptoms of spinal myelitis rapidly follow, and a fatal issue often occurs at an early date from toxaemia following septic cystitis or sloughing of the nates. The special phenomena of paraplegia are dealt with at p. 641. The Prognosis of these cases turns largely on the situation of Fig. 232. — Complete Fracture -Dislocation of the Spine in the Lower Dorsal Region with Displacement, and Compression of the Cord. (After Keen and White.) INJURIES OF THE SPINE 633 the injury and the amount of mischief sustained by the cord. The higher the lesion, the greater the danger, although patients with paraplegia from cervical fracture may live for years, and even partially recover, if the cord has not been totally disintegrated. The Treatment naturally varies with the character of the case. The patient is carefully placed on a prepared bed, the greatest gentleness being used in handling and lifting him, for fear of increasing the damage to the cord. The bed must be firm, though not hard ; perhaps the best type to employ is a horsehair mattress placed over fracture-boards ; nothing more soft or yielding is per- missible. Spring beds and wire-wove mattresses are most undesir- able. A water-bed is required in the later stages, but should not be used at first, as it is scarcely firm enough. The shock resulting from the accident is treated in the usual way by warmth and, if need be, by stimulants; but it must be remembered that anaesthetic regions of the body can be easily blistered or burnt by hot-water bottles, unless carefully guarded by flannels. When reaction has occurred, a more thorough examination of the patient can be made, and the subsequent course of action decided on. (a) In a small minority of the cases operative treatment is justifiable. We shall discuss later on (p. 644) the indications for laminectomy. (b) When the displacement persists owing to impaction of the fragments, reduction under an anaesthetic may possibly be under- taken, provided that the lesion is not in the cervical region, and the paraplegia not complete. Of course, if other internal injuries are present which render the case hopeless, nothing should be done. Great care must be used in attempting reduction, since the object is to relieve pressure on the cord, and any undue violence may readily increase the mischief; in the lumbar region, however, considerable force may be employed without much danger. Whether reduction is accomplished or not, the further treatment must be directed in accordance with the indications given in the next paragraph. Where the surgeon fails to reduce the deformity, it may sometimes be advisable to make gradual extension from the feet or neck by the use of weight and pulley. (c) In many cases, as soon as the patient is laid flat on a bed, the displacement remedies itself, especially if the spine has been comminuted, and then the treatment must be symptomatic, as also after reduction or operation, where the paraplegia persists or is only slowly recovered from. He is kept in bed, absolutely flat, and with the head low ; perhaps some form of mechanical sup- port, e.g., a plaster of Paris or leather jacket, may be considered advisable ; but its application is always a matter of difficulty, and in the early stages it does but little good. Food is regularly administered, and at first must be light and readily assimilable. The chief care of the attendants must be directed to the skin, bladder, and bowels. Bedsores are extremely liable to form on all points of pressure, and hence the nates and heels must be care- 634 A MANUAL OF SURGERY fully guarded (p. 80). In turning the patient to attend to the nates, the body must be rolled over as a whole, and not merely the pelvis twisted. It will often be found advisable to have a divided mattress placed beneath the pelvis, so that one lateral segment may be removed at a time, and thus rotation of the body will not be needed. A bedpan can also be used in this way without disturbing the spine. When the bladder is paralyzed, the urine must be withdrawn by a catheter. One of the greatest dangers that the patient runs is from the supervention of septic cystitis, and the extension of the inflammation upwards to the kidneys. This is always due to infection from without, and the greatest care must be taken to prevent it. The penis should be thoroughly purified, and the urethra well flushed out before passing an instrument in these cases ; in the intervals between instrumentation the penis is wrapped in a dry antiseptic or sterilized dressing. Only soft rubber catheters are employed, and these must be kept absolutely aseptic by immersion in 5 per cent, carbolic lotion, or 1-1000 sublimate, which is subsequently re- moved before use by washing with a solution of boric acid. Should sepsis occur, the bladder is irrigated twice daily with some mild antiseptic, such as Condy's fluid, boric acid, boro- glyceride (1 in 20), or sanitas (1 in 20), whilst urotropine, salol or boric acid in 10 grain doses may be administered by the mouth thrice daily. Probably, in spite of all precautions, the condition will persist, and prove fatal from extension to the kidneys. The bowels are always obstinately constipated, and must be opened either by purgatives or simple enemata. Under such a regime the patient may gradually recover, but more often succumbs to septic poisoning or exhaustion. Occa- sionally he may live for a long time, although paralyzed, possibly developing some amount of reflex micturition, if the lumbar centres are not involved. Varying degress of restoration of power in the lower limbs are also met with. Dislocations of the Spine. By dislocation of the spine is meant a displacement forwards, either partial or complete, of the upper part of the spine, with separation of the articular processes, and tearing of the inter- vertebral substance. A pure dislocation can only occur in the cervical region, and even then it is not uncommonly associated with a fracture. The reason for this depends partly on the immobility of the dorsal and lumbar vertebrae in the latter regions, and partly on the direction of their articular processes. In the cervical region these look mainly upwards and downwards, with a slight slope forwards and backwards, so that it is not difficult for one to slip over the other ; in the dorsal region they are placed nearly vertical, looking forwards and backwards, whilst in the lumbar they are also vertical, but look inwards and outwards, the INJURIES OF THE SPINE 635 lower enclosing the upper as in a sheath, so that in the last two regions of the spine dislocation is impossible without concurrent fracture of the articular processes and probably of the lamina?. Any part of the cervical region may be the seat of a dislocation. The occiput has been displaced from the atlas in a few cases, resulting in sudden death ; but if incomplete, life has been pro- longed for a few hours or days. Dislocation of the atlas from the axis has followed blows on the neck, or has been the cause of death in hanging, whilst the attempt to lift a struggling child by the head has sometimes led to this calamity. In almost all cases the odontoid process has been fractured or the transverse liga- ment torn, causing instant death from compression of the cord, owing to the head and atlas slipping forwards. Lateral displace- ment from rotation has also been observed, the cord symptoms then being of a milder type. Dislocation may occur between any two of the lower five cervical vertebra, but perhaps most frequently between the fifth and sixth. It is almost invariably the result of forcible flexion of the head and neck, perhaps combined with rotation, and as a rule the intervertebral articulations are torn open, whilst the supraspinous and interspinous ligaments, the ligamenta subflava, and the anterior and posterior common ligaments, are lacerated, and the intervertebral substance torn across, or a scale of the articular surface detached. The head and upper portion of the spine are displaced forwards, so that the cartilaginous surfaces of the articular processes of the lower vertebra project behind the lamina? and transverse processes of the upper, and the lower articular processes of the upper vertebra lie within the inter- vertebral notch of the lower bone (Fig. 233, A and B, a). Two forms of dislocation are met w T ith — the unilateral and bilateral. (a) Unilateral Dislocations of the cervical spine is due to force applied from the back and side of the neck. The head is turned towards the opposite side, and more or less fixed, whilst there is no evidence of compression of the cord, although a tingling and neuralgic pain along the course of the nerves may arise from pressure upon and stretching of the nerve trunks in the inter- vertebral notch. The spinous processes may be irregular and displaced laterally, whilst the line of the transverse processes is similarly altered ; such signs are, however, very difficult to make out in thick necks. If left unreduced, the vertebra becomes fixed in its new position, the head and neck displaced, and permanent neuralgia may result. In such cases, if seen early, replacement may be attempted. The patient is anaesthetized, the body fixed, the head and neck flexed, and traction made in that position, so as to unlock the edges of the articular processes. Reduction may be accomplished with a definite snap or catch. In old-standing cases an operation may sometimes be attempted to relieve pressure on the nerves, but it is impossible to replace the bones. 6 3 6 A MANUAL OF SURGERY (b) Bilateral Dislocation (Fig. 233, A and B), if complete, is always accompanied with pressure upon the cord and paraplegia ; occasionally, however, it is only partial, and then the cord may escape without immediate injury, owing to the large size of the canal in this region ; haemorrhage and inflammation may subse- quently cause grave symptoms. Treatment is of but little avail in most of the cases of complete double dislocation, since probably the cord is irretrievably damaged ; but where paraplegia is incom- Fig. 233. — Dislocation of the Cervical Spine. (After Keen and White.) A, As seen from in front ; B, side-view ; aa indicate the lower articular facets of the upper or displaced vertebra, which are thus seen to lie in front of the upper articular processes of the lower vertebra. plete it is possible that benefit may arise from early interference. Replacement by traction on the head with the neck flexed may be first carefully tried, and failing that laminectomy should be performed. After stripping the muscles from the bones, the surgeon will see the two cartilage-covered surfaces of the upper articular processes of the lower vertebra standing out clearly behind the laminae of the displaced bone. Upward traction on the head may now again be made, and reduction thus attempted ; but if this does not succeed, as small a portion as possible of the upper margins of the exposed articular processes is excised in order to INyURIES OF THE SPINE 637 allow of the unlocking of the bones ; if the whole processes are removed, reduction is much easier, but Nature's barrier to prevent a recurrence of the trouble has been taken away, and fixation of the spinal column in its natural position becomes impossible. The sudden relief of pressure not uncommonly causes such an interference with the intravascular tension in the cervical cord as to lead to a temporary cessation of the breathing, for which artificial respiration is required. It is usually advisable not only to replace the bones, but also to open the spinal canal and mem- branes, so as to remove any pressure of blood or inflammatory exudation which may exist. The results of such operations are not particularly satisfactory. Secondary Effects following Spinal Injuries. Injuries of the spinal column are frequently associated with, or followed by, conditions affecting the cord and its membranes which may lead to the gravest results, even when the local lesion to the spine has been comparatively slight. These are frequently combined with one another in the most puzzling fashion, so that it is often difficult to state the exact nature of a certain group of symptoms ; for simplicity's sake we shall discuss them here without attempt- ing to describe the various combinations which may present themselves. The following secondary effects may be met with after spinal injuries : (a) Direct spinal concussion ; (b) spinal haemorrhage ; (c) spinal meningitis ; (d) spinal myelitis; and (e) spinal neurasthenia (or railway spine). Direct Concussion. — This condition may be due to severe blows in the back, which do but little damage to the spinal column, or may be caused by accidents which lead to the infliction of greater mischief, but without an)' serious dis- placement of parts. The term ' concussion ' should be limited to those cases where energetic traumatic influences (falls, bloics, collisions, etc.) have given rise to severe disturbance of the functions of the cord without any considerable visible anatomical changes in the latter (Erb). In fact, the term is really only applicable to those cases which recover more or less completely ; if recovery does not ensue, minute extravasations or other lesions have been present, constituting a con- dition of contusion rather than concussion. It is somewhat doubtful, however, whether all these cases are not due to minute haemorrhages. The Symptoms produced are those of a more or less complete and immediate loss of function of that portion of the cord situated below the point struck. Thus, a varying degree of paraplegia is produced, the signs of which differ with the region affected (see p. 643). In addition, the patient is usually prostrate from general shock to the system, and the reflexes are often totally lost — at any rate, for a time — as a result of the shock to the cord. Death may be caused at once by a blow in the upper cervical region, or varying degrees of loss of power and sensation may be produced in any or all of the limbs. In the lower cervical region the arms are mainly affected, and perhaps some par- ticular nerve may be picked out and paralyzed. In the lumbar and dorsal regions a more typical paraplegia is produced, with loss of power over the sphincters, and loss of reflexes. Priapism never occurs in simple concussion. The temperature of the body may be depressed, and the extremities pallid and cold ; the pulse is rapid and weak, and the respirations shallow. The Prognosis is always uncertain, as in cases where there is no displace- ment it is impossible to gauge the extent of the mischief. If merely con- cussion is present, the patient is likely to recover ; if the cord is contused, or haemorrhage has occurred into it, a perfect recovery can scarcely be expected. In the Treatment absolute rest to the spine is of the greatest importance, and £38 A MANUAL OF SURGERY this should be maintained if possible in the prone position, so as not only to diminish static congestion, but also to remove any pressure on the spine, and to allow topical applications to be made. A spinal icebag may be applied, or the back may be dry-cupped, whilst the patient is kept absolutely still, and on a low diet. The bladder and bowels need attention, but no special drugs are necessary. Of course, local injuries require suitable treatment. Spinal Haemorrhage. — We can here only discuss the subject of spinal haemor- rhage as resulting from injuries. It also occurs apart from traumatism, and it is interesting to note that such happens more frequently in young persons between the ages of ten and twenty than in old people, as with cerebral haemorrhage. The bleeding may take place either into the cord itself, or out- side it, and hence the two following varieties are described : (a) Intramedullary Haemorrhage, or spinal apoplexy (hcematomyelia) , is met with as a result of injury, which need not necessarily involve the spinal column ; the lower cervical region is the part usually affected. Extravasation into the cord is rarely extensive, and may occur in the form of one clot, usually not larger than an almond, or more commonly in many spots, the gray matter being more or less ploughed up. The white matter is compressed, and some- times the blood bursts through it into the membranes. Should the patient survive the injury for any length of time, secondary degenerations are estab- lished, and run the usual course. The patient is suddenly struck down with a more or less complete paraplegia, and with perhaps pain in the back, the phenomena being very similar to those of a transverse myelitis. Some degree of recovery follows, but the parts supplied from the damaged portion of gray matter are likely to remain paralyzed. The Diagnosis of haemorrhage turns on the rapid onset of paraplegia, which may be incomplete, without spinal irritation ; fever may ensue for a few days, and if the cervical region is affected, extreme contraction of the pupil (myosis) may result from destruction of the cilio-spinal centre. The Prognosis depends on the size and situation of the clot, a large clot producing more injury than a small one ; haemorrhage in the cervical region may be immediately fatal by interference with the respira- tion, whilst in the lumbar region it is unfavourable on account of the effect upon the sphincter centres. The outlook is best when the dorsal portion of the cord is affected. The Treatment is the same as was indicated for direct concussion, whilst the administration of ergot may be beneficial. (b) Extrameduilary Haemorrhage (iiamatoraehis) is a more frequent complica- tion of spinal injuries, such as sprains or limited fractures, than the former. The blood is usually extravasated between the bones and the dura mater, especially in the cervical region, but may occasionally be found within the dura having trickled down from the upper part of the column. The symptoms are, in brief, those of spinal irritation, e.g., pain, hyperaesthesia, spasms, cramps, etc., rapidly followed by loss of power in the muscles supplied from the damaged area, or by ' gravitation paraplegia' (Thorburn), which gradually extends from below upwards, causing death by asphyxia, the whole series of phenomena being afebrile. In intramedullary haemorrhage the symptoms of paralysis are more evident, and those of spinal irritation less marked. If a diagnosis can be made, ergotin may be injected, and ice applied to the spine, or even laminectomy performed to relieve pressure ; later on, prolonged rest may cause the absorption of the clot, and even total restoration to health. Spinal Meningitis. — Inflammatory conditions of the spinal membranes may spread downwards from the head, or commence as a local affection. Two forms are met with resulting from injury : (a) In Acute Spinal Meningitis the inflammation mainly affects the arachnoid and pia mater (leptomeningitis). It is usually generalized in distribution, and not unfrequently extends to the cerebral membranes. It occasionally follows INJURY OF THE SPINE 639 simple injuries, but is always infective in origin, being due to a diplococcus (? pneumococcus) in subcutaneous injuries, or to the ordinary pyogenic cocci in open wounds. Pathologically , it is evidenced by hyperaemia and loss of polish of all the membranes, with an abundant exudation ; later on, lymph or even pus may collect, especially about the posterior surface of the cord ; should the patient live, organization of the effused lymph may lead to ex- tensive adhesions. Clinically, the disease is usually ushered in by a rigor, especially in the septic cases, and then runs a marked pyrexial course The symptoms are : pain in the back, deep-seated, boring, and severe, in- creased on all movements, and often extending down the limbs or around the body ; rigidity of the spine and limbs, accompanied by painful cramps and muscular spasms, almost simulating tetanic convulsions ; extreme hyper- aesthesia, especially of the legs, and increased reflex excitability; whilst rapid emaciation from pain and sleeplessness is soon produced. If the condition is limited to the spine, it is probably followed by signs of myelitis, viz., para- plegia, together with bedsores and vesical troubles, and these may lead to a fatal issue ; cases, however, are met with which pass into a chronic state, and may more or less recover. If the process also involves the cerebral mem- branes, as in septic cases, the symptoms of diffuse cerebral meningitis are also present, and the patient dies of coma. Treatment in the cases due to a penetrating injury is of no avail if prevention of the disease by asepsis fails. In simple cases an icebag should be applied to the spine, the patient remaining in the prone position. Ergot and belladonna may be given internally, and general measures to allay inflammation adopted. The bladder and rectum must be attended to, and bromides and chloral administered to gain sleep. (b) Chronic Meningitis is usually localized, and may occur either as an inflammation of the arachnoid and pia mater (leptomeningitis), or be mainly limited to the dura mater (pachymeningitis). It either originates as a chronic affection, or is the sequela of an acute attack, and is more likely to supervene in syphilitic individuals. The membranes become hyperaemic and thickened, and adhesions between the cord and its membranes may occur. The extensions of pia mater into the cord readily explain the fact that a chronic sclerosing myelitis is frequently associated with this affection. The Symptoms are those of localized pain and rigidity in the back, increased on all movements, and accompanied by shooting pains and hyperaesthesia, and perhaps muscular pains and cramps. The reflexes are usually exaggerated, and vesical com- plications may follow. Treatment consists in prolonged rest, with counter- irritation in the* form of blisters or the button cautery applied to the back, whilst mercury is administered internally. Spinal Myelitis. — Inflammation of the spinal cord may follow injuries of the spine, either as a direct consequence of depressed or displaced bone, or from simple concussion or contusion with haemorrhage ; it may also be caused at a later date by extension of inflammation from the meninges, or result from com- pression by lymph, pus, granulation or cicatricial tissue, or callus. It may be acute or chronic. In the former the cord becomes red and softened; the nerve elements are destroyed, and finally replaced by cicatricial tissue if the patient live long enough. In chronic cases the connective tissue becomes thickened, and the nerve structures compressed and disintegrated, whilst the meninges are always adherent and thickened. Symptoms. — Acute Myelitis is evidenced by the presence of pain in the back and along the course of the nerves arising from the inflamed area, hyper- aesthesia, and muscular cramps in the earlier stages, soon followed by paralytic symptoms, if these are not already present as the result of the injury. The irritative symptoms are, however, much less marked than in acute meningitis The reflexes vary according to the amount of destruction of the cord substance, whilst muscular atrophy is not especially rapid, except in those muscles formerly supplied from the affected area. The sphincters of both bladder and 640 A MANUAL OF SURGERY rectum are paralyzed, causing retention of urine and incontinence of faeces; the former is almost invariably followed by septic cystitis, especially when the trophic centres in the lumbar enlargement are involved. Bedsores are very liable to be produced, and may become very extensive and serious. Priapism and hyperpyrexia are often present when the cervical region is affected. The fatal issue is usually due to septic poisoning from the urinary tract, or perhaps from the bedsores. Chronic Myelitis gives rise to a great variety of symptoms, but those most marked are a gradually increasing motor weakness, going on to paralysis, together with various sensory phenomena ending in anaesthesia, whilst there is trouble with the bladder and rectum. The treatment of each of these conditions is mainly symptomatic. Spinal, or Traumatic, Neurasthenia (Syn. : Railway Spine, Indirect Concus- sion of the Spine). — Cases are not uncommonly met with in which, although there has been no direct injury to the spinal column or cord, and no immediate symptoms of importance, the fact is manifestly demonstrated in various ways that considerable commotion and disturbance have been produced in the nervous system. Railway accidents are the most common cause of this con- dition, but it may arise from any jar to the spinal column. The reason why railway accidents are so often responsible for this state is that the forces employed are very great, and the collision unexpected, so that the muscles and ligaments are taken at a disadvantage, being off their guard, whilst the shock, terror, and mental disturbance are also important factors. Ligamentous and muscular lesions — i.e., sprains and strains — are the usual local phenomena produced by such accidents. In the majority of cases the symptoms are mainly due to excessive irrit- ability and weakness of the spinal and cerebral centres, constituting a condi- tion of nerve prostration, or Neurasthenia, and the history will usually be some- what of this type : The individual at the time of the accident is thrown from side to side, or severely shaken, but does not lose consciousness, and, although feeling somewhat dazed, is able to alight without help, and may even assist others. He perhaps continues his journey, and goes to his business, but finds in the course of a few hours that his back is painful, his head aching, and that he cannot apply himself to his work. He returns home and goes to bed, sending for his doctor, who will probably prescribe rest and bromides. His condition remains for a time unaltered ; he complains of pain and tenderness over certain regions of the spine, especially the lumbar, and is unable to walk, or to undertake any serious mental or physical effort, whilst all exces- sive sensory stimuli, such as a bright light or noise, are unusually disturbing. Neuralgia is often present, whilst the pulse is weak ; the urine may be retained or may dribble away, and the temperature be for a time subnormal. Accom- modative asthenopia (or the inability to accommodate for near objects), result- ing in a temporary condition of presbyopia, is also a marked feature in many of these cases. All the symptoms are aggravated by mental excitement and exertion, such as are often produced by the necessary interviews with doctors and solicitors pending the financial compensation by the railway company. The immediate improvement which often follows the satisfactory settlement of his claim for damages is not necessarily due to imposture, but may result from the removal of mental tension and anxiety. This condition of neurasthenia may develop immediately after the accident, as an acute condition, the patient lying helpless and prostrate, or more often chronically, as in the more common type of cases described above. To it, however, is frequently added a considerable element of Hysteria, in the form either of acute attacks of hysterics, or of a chronic unconscious exaggeration of the sensory symptoms. If the patient is examined in the supposed hyper- aesthetic area whilst his attention is distracted, possibly no pain will be com- plained of. The Prognosis is generally favourable, the patient recovering in time, but in a few instances permanent effects may be produced. INJURY OF THE SPINE 641 In the Treatment, a good deal of care is needed to judge rightly when the period has arrived for encouraging movement rather than rest, and thus to prevent the patient from developing a condition of chronic invalidism. Re.U in bed is to be recommended at first, bromides given in moderation, and fomen- tations applied locally. Later on, friction with liniments and massage should be employed, and when all chance of secondary inflammatory disturbance is at an end, movement should be encouraged, and change of air advised, whilst a course of strychnine and iron may be administered. In a few cases, however, fortunately much rarer, the symptoms run on into those of a chronic inflammatory condition of the spinal cord and its membranes, and these, to which Erichsen formerly applied the term Indirect Concussion, are of the gravest import. In others, nothing may be noticed by the patient for some weeks or months beyond the fact that he feels a little shaken, and not so capable of doing his work as formerly ; but, at the same time, he loses flesh, and looks worn and fagged. Gradually other phenomena develop. His brain power is diminished, and any mental effort causes him to be muddled ; memory fails, the temper is irritable, and his sleep disturbed ; the head is often hot. The vision is usually defective, and he complains of noises in the ears. The sense of touch is impaired, so that all delicate movements are hindered. The spine is kept rigidly stiff, the head fixed, and the gait is somewhat unsteady and shambling ; the walking powers are much diminished, and going up and down stairs is espe- cially difficult. Motor power in all regions of the body is partly lost ; any or every modification of sensation may be met with, whilst the reflexes are increased The bladder may lose its power of retaining urine for a time, but this is not always a marked symptom ; there is great impairment of both sexual desire and power. On examining the back, distinct tenderness is felt over one or more spots, especially in the lower cervical, mid-dorsal, and lumbar regions. In such cases, where the symptoms develop slowly, and remain unaltered by treatment, the Prognosis is most unfavourable, since they are probably due to inflammatory changes in the cord and brain, and although the patient may live for years, yet he is permanently crirpled, and becomes a confirmed invalid. Treatment in the earlier stages consists of rest, preferably on a prone couch, with counter-irritation, such as blisters, or even the actual cautery, over the spine, whilst mercury or iodide of potash, and bark, are administered. Careful nursing and massage of the limbs, or galvanism, are needed, and warm sea- water douches may be most useful. If, however, no improvement follows, the patient must be encouraged to get about as best he can, and to go out in an invalid chair, so as to maintain the general health, whilst careful attention is directed to the personal hygiene. Paraplegia. Paraplegia arises in the course of spinal injuries from a variety of causes, which may be classified as follows : 1 . Paraplegia arising immediately after the accident, from : (a) Direct concussion without evident lesion, if such a condition be possible ; (b) Disintegration of the cord from intramedullary haemor- rhage, or from contusion without displacement of bone ; (c) Displacement of bones, with or without recoil, crushing the cord ; (d) Penetrating wounds dividing the cord. However produced, the same symptoms manifest themselves if the lesion is complete ; recovery is alone possible in the first and 4i 642 A MANUAL OF SURGERY perhaps in the second group, whilst in the other forms the para- plegia is maintained by a subsequent acute transverse myelitis. 2. Paraplegia arising after an interval, from : (a) Extramedullary spinal haemorrhage, if the symptoms show themselves without pyrexia in twenty-four or forty-eight hours ; (b) The pressure of inflammatory exudations, as in spinal meningitis, when the symptoms are preceded by inflammatory phenomena, and do not appear before seventy-two hours at the earliest ; (c) The pressure of callus or of cicatricial adhesions around the cord and membranes (i.e., peri-pachymeningitis). It is unnecessary to discuss further the special signs and symptoms accompanying each form ; they have been already mentioned. We merely propose to indicate briefly the effects of a total transverse lesion, and then to describe the results of paraplegia as they vary with the situation of the injury. It must be remembered that the nerves are derived from spinal segments which are always at a higher level than the exit of the nerves from the canal — i.e., the nerves travel downwards within the spinal canal for a variable distance, less in the cervical region, more in the lumbar, before escaping through the inter-vertebral foramina. A Total Transverse Lesion, destroying absolutely one segment of the cord, will result in the following symptoms : i. Paralysis of the muscular area supplied by the destroyed segment, followed by rapid atrophy, reaction of degeneration, and loss of reflexes in this particular group of muscles. 2. Paralysis of all the muscles supplied by the segments below that which has been destroyed. The trophic condition remains normal, at any rate, for a time, but when secondary descending degeneration in the antero-lateral columns has occurred, the muscles become contracted, tense, and rigid (late rigidity). The condition of the reflexes after a total transverse lesion has been a fertile source of discussion, but it is now maintained that the deep reflexes are entirely and permanently lost, whilst the superficial reflexes, though absent for a time, may reappear. If, however, a portion of the cord remains intact, both superficial and deep reflexes may persist or reappear, and even be exaggerated. 3. Complete anaesthesia of the sensitive area supplied by the destroyed segment, and of all the sensitive areas below. 4. A narrow zone of hyperesthesia is found at the upper level of the anaesthetic area, due to the irritation of the nerve roots at the site of injury. 5. Vasomotor paralysis combined with trophic disturbances in the parts which are paralyzed. 6. Visceral changes, especially in the bladder and rectum. INJURY OF THE SPINE 643 Phenomena of Paraplegia at Different Levels. 1. At the Upper End of the Sacrum. — Total transverse lesions at this spot are exceedingly rare ; they only involve the cauda equina and cause paralysis of the sacral plexus. The effects produced are : (i.) Paralysis of all the muscles of the legs, except those supplied by the anterior crural nerve, the obturator, and the superior gluteal, whilst the perineal and penile muscles are also affected, (ii.) Anaesthesia of the penis, scrotum, perineum, lower half of the gluteal region, and the whole of the legs except the front and outer part of the thigh, supplied by the cutaneous branches of the anterior crural, and the region supplied by the long saphena. (iii.) The bladder and rectum are both shut off from their spinal centres, and hence there will be tem- porary retention of urine, followed by distension with overflow, and incontinence of faeces. The bladder, however, gradually contracts, its walls become thickened, and its capacity steadily diminishes, so that incontinence becomes more and more absolute. 2. If the lesion is situated in the Dorsi-lumbar region, or passes through the lumbar enlargement, which corresponds to the twelfth dorsal and first lumbar vertebrae, there is complete paralysis of the muscles of both limbs, including those passing to them from the trunk ; total anaesthesia of the legs, gluteal and perineal regions, and possibly the lower part of the abdomen ; whilst, if the vesical centres are destroyed, there is total paralysis of the bladder, with relaxation of the sphincter, dribbling of urine, which early becomes ammoniacal, and cystitis, due to trophic changes ; if the centres escape, retention with overflow is the usual result : the rectum and sphincter ani are paralyzed, causing incontinence of faeces, the passage of which is unrecognised from the anaesthetic condition of the anus. 3. In the Mid-dorsal region the same phenomena are met with, but to them are added a more extensive region of anaesthesia, limited above by a hyperaesthetic zone, which feels like a tight painful girdle round the waist ; paralysis of the flat abdominal muscles ; retention of urine, followed by distension with over- flow, which, however, when asepsis is maintained, may occa- sionally be followed by a state of reflex micturition in which the patient passes water unconsciously and involuntarily, whenever there is sufficient present to cause sensory stimuli to ascend to the undamaged centres. The abdominal paralysis is a most important addition to the gravity of the case, for all straining movements are thereby prevented, and thus coughing is em- barrassed and defaecation hindered. The gases developing from the stagnant faeces accumulate and cause distension of the belly (meteorism), and thereby respiration may be seriously impaired. The diaphragm, moreover, is hampered in its action, since the lower ribs cannot be fixed or steadied, and hence its contractions 41—2 644 A MANUAL OF SURGERY tend to pull them inwards, instead of increasing the dimensions of the thoracic cavity. 4. In the Cervico - dorsal region all these phenomena are present, but the anaesthesia extends over nearly the whole trunk, and the hyperesthesia may involve the arms, whilst the inter- costal and spinal muscles are also paralyzed. Respiration has therefore to be carried on by the hampered diaphragm, with the assistance of a few of the accessory respiratory muscles in the neck, and hence is much impeded ; if bronchitis is present, it will prove fatal by asphyxia in a few days from the inability to expectorate. Priapism is a marked feature of cervical paraplegia. 5. In the Lower Cervical region the arms also become involved in both the paralysis and anaesthesia, and if the lesion is situated at or above the fourth cervical vertebra, instant death results from paralysis of the phrenics and consequent stoppage of the respiration. Death from Paraplegia, therefore, may arise from a variety of causes and at various periods. It may be immediate, from respiratory failure in lesions above the fourth cervical vertebra ; or it may occur from accumulation of mucus or pus in the air-passages, when the lesion is in the upper dorsal region ; or it may be delayed for weeks, or even months, and then is due to sloughing of the nates, or septic absorption from an inflamed or ulcerated bladder, which is often associated with suppurative pyelonephritis. The Prognosis and Treatment both depend on the position and character of the lesion causing the paraplegia, and on the previous habits and condition of health of the individual. Laminectomy. By laminectomy, or, as it used to be badly termed, trephining the spine, is meant an operation for the removal of the lamina? and spinous processes of one or more vertebrae, in order to relieve pressure on the cord, whether due to depressed bone, abscess, granulation tissue, excessive callus, cicatrices, or tumours. The operation consists in making a longitudinal incision in the middle line of the back, extending to the spinous processes ; the muscular and tendinous structures are then cleared from the posterior aspect of the vertebrae as far as the transverse processes, a proceeding usually attended with considerable haemorrhage, which can be checked, perhaps, better by hot sponge pressure than by attempt- ing to secure the individual vessels. The neural arches are then examined for injury, etc., and those which seem to be most affected removed by cutting pliers, Hey's saw, or laminectomy forceps. The posterior aspect of the membranes of the spinal cord is thus exposed, and the various conditions which may be present are dealt with according to circumstances. In this place INJURY OF THE SPINE 645 we have merely to consider the use of this operation after injury to the spine. For its employment in other conditions, see Chapter XXII. Much controversy has arisen as to the value of this operation and the circumstances under which it may be justifiable. It must be remembered as a fundamental guiding principle that repair is impossible after the spinal cord has been divided, or any one segment totally disintegrated, and hence, if it is certain that a total transverse lesion of the cord has been caused by an accident, it is absolutely useless to operate. Early and complete disappearance of all the reflexes is a suggestive phenomenon, but cannot be looked on as absolute evidence of a total transverse lesion ; if, however, the deep reflexes remain absent for an) length of time, even though some of the superficial ones have reappeared, operation is useless. The presence of the deep reflexes is always an evidence that at any rate a portion of the cord remains uninjured, and would encourage one to operate, This question cannot, however, be absolutely settled in the early stages of the case, when an exploration is likely to be of most service, and therefore there will always be a certain number of cases in which it will be a matter of doubt as to whether or not any benefit will accrue from operation. The final decision undei such circumstances will depend on the special predilections and opinions of the surgeon who is in charge of the case, and the general state of the patient. Apart from these doubtful cases, the following are generally admitted as being suitable for operation : (1) Penetrating wounds or fractures with displacement which involve the spine below the first lumbar vertebra ; the cauda equina is present below that level, and not the spinal cord, and it is reasonable to treat it in the same way as one would treat a single peripheral nerve ; (2) when the injury is mainly limited to the neural arch, which has been driven in by direct violence ; (3) in all cases of bilateral dislocation of the cervical spine where the patient is not moribund ; (4) if paraplegia arises with or without inflammatory symptoms, when an interval has elapsed since the accident ; the pressure in such cases may be produced by blood or inflammatory exudations, and benefit may possibly arise from the operation ; if, however, it is due to a total transverse myelitis, no good can follow. (5) When symptoms of irritation or paralysis supervene at a later date, from contraction of cicatrices around the cord or its membranes (peri-pachymeningitis), or from excessive callus formation, lamin- ectomy may be performed with good hopes of a successful result. CHAPTER XXII. DISEASES OF THE SPINE. Spina Bifida. By Spina Bifida is meant a condition of imperfect development of some portion of the posterior aspect of the spine, with or without a similar affection of the spinal cord and membranes. It must be remembered that the spinal cord is developed as a linear involution of the epiblast, the edges of this medullary groove growing up and uniting, so as to include a passage lined with epithelium, and subsequently known as the central canal. The cord is gradually separated from the overlying skin by an intrusion of mesoblastic elements, from which the vertebrae, together with the spinal muscles and ligaments, are developed. The ossification of each vertebra originates in three main centres — one for the body, and one for each half of the neural arch, whilst epiphyses are developed as plates above and below the body, as also for the transverse and spinous processes. The following are the chief forms of spina bifida : i. A Myelocele results from non-closure of the primitive medullary groove. It is characterized by the appearance in the lumbo-sacral region of a raw surface, which consists of the spread- out structures of the spinal cord, at the upper part of which opens the central canal. The condition is evidently incompatible with life, and the children, if they are not stillborn, as is usually the case, do not live beyond a day or two. 2. A Syringo-myelocele (Fig. 234) arises from a distension of the central canal of the cord, the posterior portion of which usually remains adherent to the skin, from which it has never been separated, owing to defective development of the meso- blastic tissues. The spinal nerves travel round the walls of the cyst in order to find their way to the intervertebral foramina. Trophic phenomena are nearly always a prominent feature of these cases. 3. A Meningomyelocele (Fig. 235) is due to a development of fluid within the membranes which remain adherent to the skin, DISEASES OF THE SPINE 647 the spinal cord or nerves of the cauda equina passing down the posterior aspect of the cavity as a strap, and the nerves traversing and perforating the sac to reach the intervertebral foramina. 4. A Meningocele (Fig. 236) is characterized by a protrusion of the membranes, containing cerebro-spinal fluid, through a defect in the posterior walls of the vertebrae, the spinal cord and nerves being in their normal position. This variety is uncommon. Of these forms, the meningo-myelocele is that most frequently seen in living children, although, according to Bland Sutton, from whose book on Tumours the above description is mainly derived, the first is really the most common. Clinical Characters. — A spina bifida is recognised by the appear- ance of a tumour in the middle line of the back (Fig. 237), most commonly involving the lower part of the spine ; it may be covered by normal skin, but usually that over the apex is thin and translucent, and not unfrequently a number of small dilated vessels are seen coursing over it. On compressing the tumour, Fig. 234. — Diagram of Fig. 235. — Diagram of Fig. 236. — Diagram Svringo-Myelocele. Meningo-Myelocele. of Meningocele. S C, spinal cord ; CSF, cerebro-spinal fluid in sac ; N, nerves. its size can be diminished, and in infants distension of the anterior fontanelle can be felt, showing that the sac is filled with cerebro- spinal fluid, and there is always a distinct impulse on coughing or crying. The defect in the posterior portion of the vertebras is very evident, the edges of the bones being felt at the margins of the tumour. Various other deformities may be associated with spina bifida, especially hydrocephalus and talipes, which are perhaps most common in cases of syringo-myelocele, whilst per- forating ulcer, ankylosis of the terminal phalanges of the toes, and other trophic phenomena, are also developed, perhaps at a much later date. The Prognosis of the case depends mainly on the thickness and character of the overlying skin. If it is thin, and the cord evidently adherent to it, as sometimes indicated by a cicatricial depression or dimple, the sac is very likely to give way, causing either death from sudden escape of cerebro-spinal fluid, or a fatal issue in a few days from septic meningitis. If the spina bifida is small, and covered with healthy skin and subcutaneous tissue, the 6 4 S A MANUAL OF SURGERY patient may reach adult life, but even then trophic phenomena may supervene. Occasionally a meningocele, with only a small aperture of communication with the spinal canal, is cured spontaneously by the gradual development of the bones con- stricting the neck of the sac. Treatment. — The majority of these cases are best left alone, the tumour being merely] guarded from injury by the application of a suitable cap. If the sac is gradually increasing in size, and threatening to give way, operative interference is absolutely necessary if life is to be saved. Acupuncture through the thinned integument, the cerebro - spinal fluid being allowed to drain away subsequently into an antiseptic dressing, or tapping through the healthier integument around the base, repeated several times, and followed by compres- sion, may lead to a cure in favour- able cases. Statistics, however, go to prove that the best results are obtained by tapping, followed by the injection of Morton's fluid (R : iodi, grs. x. ; pot. iod., grs. xxx. ; glycerinum, ad ^i.). A small quantity of the cerebro-spinal fluid is withdrawn, and then from half a drachm to a drachm of the iodine solution is introduced. It diffuses itself slowly, and tends to act locally, so that if the child is kept quiet, and only semi-recumbent, its effect will be limited to the sac of the spina bifida and its neighbour- hood. In some cases persistent leakage may follow this treatment, Fig. 237. — Spina Bifida in Lad aged Sixteen, probably of the meningo-myelocele Type. (From a Photograph.) The swelling had not increased much in size since he was a child, but distinct trophic phenomena were being de- veloped in the shape of talipes and such is dealt with by means of both feet. of a fi rm antiseptic compress; in many the injection needs to be re- peated more than once. Of late years treatment by operation has been coming more and more into vogue. Naturally, it is chiefly applicable in the meningocele type, and infants or those suffering from trophic phenomena do not stand it well. An incision is made over the sac, either in the middle line if it is certain that the cord is not there, or to one side, if it is. The child should be kept with the head low when the sac is opened, so as to limit, as far as DISEASES OF THE SPINE 649 possible, the loss of cerebro-spinal fluid. In a meningocele, the protruding membranes are cut away, the wound in them is very carefully sutured, and the spinal muscles drawn together by deep stitches, so as to create an extra protective barrier, in addition to the skin and subcutaneous tissues. When the cord runs down the back of the sac, it is freed by incisions on either side, and if it cannot be separated from the skin, the whole strip is replaced in the vertebral canal, the membranes are closed over it, and finally the muscles and skin are united by rows of sutures. The results obtained by this means have been encouraging, and in suitable cases operation may be recommended with some prospect of success. Spina Bifida Occulta is the term applied to a condition in which the posterior portion of the vertebras is absent, but without any protrusion of the cord or its membranes. The overlying skin may be cicatricial in character, or a large growth of hair may arise from it ; occasionally a lipoma develops in this situation, and by its downward growth compresses the spinal cord, causing paraplegia. Unless such a condition is present, spina bifida occulta calls for no treatment, but an exploratory operation should always be undertaken when nervous phenomena supervene. Congenital Sacral Tumours. Other congenital conditions of the lower end of the spine are described as congenital sacral or coccygeal tumours. The majority of these arise from what is known to embryologists as the neurentevic canal. In early fcetal life it is supposed that the neural and alimentary canals are continuous, the passage of communication being known by the above name. Ordinarily, it entirely dis- appears after the union of the proctodeum with the intestine, but evidences of its existence are occasionally met with, either in the form of a cicatricial dimple adherent to the tip of the coccyx [post- anal dimple), or as one of the following conditions : (i.) A dermoid cyst, containing the usual mixture of sebaceous material and epithelial cells, and often a tuft of hair ; it develops in the space between the rectum and coccyx, and may either project posteriorly, below the coccyx, or open into the rectum ; the tuft of hair may thus find its way out of the anus. In a case under the care of Mr. W. Turner, at Westminster Hospital, it was actually connected with the spinal meninges, removal involving the loss of cerebro-spinal fluid. (ii.) A tumour of a glandular or adenomatous nature is occa- sionally found in the same region. It is characterized micro- scopically by the existence of alveoli, lined by cuboidal epithelium, held together by connective tissue ; it may attain a large size, but is quite innocent. Such growths are termed by Bland Sutton 650 A MANUAL OF SURGERY thyroid-dcrmoids, but a better name would be a congenital adenoma of the post-anal gut. Various other tumours are met with in infants in this region, and the same title of congenital sacral or coccygeal tumour has sometimes been applied to them : (a) A spina bifida of the meningocele type, which may com- municate with the subdural space, or may have been shut off by a natural process of cure. (b) A lipoma may also form here, and in some cases has simu- lated by its shape a caudal appendage. (c) A partially developed foetus may be met with, enclosed within the subcutaneous tissues of the sacral region, and is known as a teratoma. (d) Sarcoma and cystic hygroma have also been observed. The conditions are so exceedingly rare that it is unnecessary to enter into details of treatment, which is conducted in accordance with general principles. Inflammatory Affections of the Spine. I. Acute Osteomyelitis of the Spine is an uncommon affection, which has only recently been recognised. It is due to the same causes as similar disease elsewhere, viz., infection with pyogenic organisms in an individual of low germicidal power. It is charac- terized by severe pain in a localized portion of the back, and fever ; deformity is not a marked feature, since massive necrosis occurs and not a gradually destructive caries. Abscesses form early, and there is great danger of an extension of the inflammation to the spinal meninges, leading to a fatal issue. The prognosis is ex- tremely bad, owing to this latter complication, and the only possible treatment consists in early incisions to give exit to the pus. Sequestra can easily be removed from the back of vertebrae, but from the front only in the lumbar and cervical regions. II. Tuberculous Disease of the Spine or Spinal Caries (Syn.: Pott's Disease, Angular Curvature). — The above names are applied to a condition due to tuberculous disease of the vertebras, originating almost invariably in their bodies, which are more or less destroyed, leading to the so-called ' angular curvature.' This latter title is misleading and inaccurate, since the deformity, though sometimes angular in character, can scarcely partake of the nature of an angle and a curve at the same time. The term ' Pott's disease ' is derived from Percival Pott, who first described it accurately in 1779. Etiology. — The causes of tuberculous disease of the spine are much the same as those of tuberculous affections elsewhere, viz. : it affects an individual predisposed to the development of tuber- culous disease either by inherited tendency, or by impairment DISEASES OF THE SPINE 651 of the general health, as from some preceding illness, or expo- sure to defective sanitary conditions. The actual deposit of tubercle is probably determined by some injury which, though slight and perhaps not noticed at the time, is sufficient to cause local diminution of vitality, thereby constituting a favourable nidus in which the Bac. tuberculosis can develop. It is most fre- quently met with in children, but may arise at any age, and equally in either sex. Sprains and strains of the vertebral column, or of the soft parts attached thereto, are the local lesions mainly responsible for it. Any part of the spinal column may be involved, but the lower dorsal is by far the commonest. The cervical region is rarely attacked, except in children, whilst in adults the dorsi- lumbar vertebrae are the favourite seat. Pathological History. — The actual changes in the bones in Pott's disease are exactly similar in nature to those we have already described as occurring generally in cancellous bone (p. 514), and no special description need be given here. The disease starts in one of two places, either under the periosteum covering the anterior sur- face of the vertebrae (this most often in adults), or at Fig. 238.— TuberculousDiseaseofSimne the line of junction of the upper or lower plate-like epiphyses with the body, the usual situation in children. In the former case the subperiosteal tuberculous deposit early extends to the subjacent bone, and spreads to neighbouring vertebrae, either along the under surface of the anterior common ligament, or through^the intervertebral discs, which are disintegrated by the process. When it spreads along the anterior common ligament (Fig. 238), the disease may be very extensive, body after body being eroded, and the intervertebral discs suffering even more than the bones. In such a case the deformity produced is not f(4L / ! showing Destruction of the Bodies of the Vertebr.e, and Abscess For- mation BENEATH THE ANTERIOR COMMON Ligament. (Modified from Specimen in College of Surgeons' Museum.) 652 A MANUAL OF SURGERY strictly angular, but rather of a general kyphotic nature. Occa- sionally, however, the disease starts simultaneously in many foci, so that the bodies of several vertebrae become pitted and carious, without producing general destruction. In other cases the process is limited to the bodies and intervertebral discs of two adjacent vertebrae, the periosteum being but little affected. This variety is, perhaps, most common in the lumbar region, where the bodies of the vertebrae are large and permit a limiting zone of sclerosed tissue to form ; it is also not uncommon in this situation to find definite sequestra (Fig. 239). The terms already described as characteristic of the different forms of caries may be applied to the varying conditions met with in this disease. Thus, when it runs its course without suppura- tion, caries sicca is said to be present ; if pus develops, as is so % :v -snaba*"-"* Fig. 239. — Tuberculous Disease of Two Lumbar Vertebra, showing Sequestrum on the Anterior Aspect, and Lateral Thickening preventing Angular Deformity. (College of Surgeons' Museum.) frequently the case, caries suppurativa ; and when sequestra occur, caries necrotica. Cure is effected by the bodies of the vertebrae falling together and becoming ankylosed, so that a deformed and immobile condi- tion of the affected portion of the spine is often the best result that can be anticipated. The new bone thus formed becomes in time sclerosed and very dense, and the synostosis also involves the spines and laminae. Occasionally, the tuberculous process extends backwards through the body of the bone so as to im- plicate the posterior common ligament, and paralytic or other symptoms may then arise from pressure on the cord. Rare cases have been described in which the disease mainly affected the sides of the vertebrae, as a result of which lateral deformity occurred ; and still more uncommon are those in which the posterior portion of the neural arches is primarily involved. In the upper cervical region the disease usually starts in the DISEASES OF THE SPINE 653 large joints, either between the occiput and atlas, or between the atlas and axis. For a time it may be limited to one side, but usually the bone is attacked at an early stage, and the trouble then spreads to other joints. A special complication of this variety will be mentioned hereafter (p. 658). The Signs and Symptoms produced by tuberculous caries of the vertebrae vary considerably in different situations, but for practical purposes may be described under the following five headings : 1. Pain is a constant and invariable accompaniment of the disease, although in the early stages it may not be specially prominent, being only elicited by careful examination. It is of two main types, the local and the referred. Local pain is more or less similar in character to that always experienced in disease of bones, although, owing to the cancellous nature of the osseous tissue involved, there is often but little tension, and hence it may be slight. It can, however, be elicited in all cases, either by pressure or percussion over the spines, or perhaps more effectually by pressing upon the transverse processes, so as to induce rotation of the vertebral bodies one on another. Movements of the spine, bending or twisting, are similarly painful, whilst the same result can be brought about by jarring the spine, as by a blow on the head or nates. The old plan of testing for pain by means of a hot sponge applied over the back is comparatively useless in this disease. Referred pain is produced by pressure upon, or irritation of, the roots of the nerves as they emerge from the intervertebral foramina ; consequently it is always noticed in those parts of the body which are supplied with sensation by the nerves issuing from the spinal canal in the diseased area. If the lumbar region is affected, the pain is referred down the legs ; in the dorsi-lumbar region it may follow the last dorsal nerve, and be noticed in the lower part of the abdomen, or in the gluteal region; in the lower dorsal region pain is referred to the epigastrium, children who are unable to differentiate its precise nature complaining of ' belly- ache'; in the upper dorsal and lower cervical regions the pain extends into the arms, whilst in the upper cervical region neuralgia follows the course of the cutaneous branches of the cervical nerves. Thus, if the third and fourth cervical nerves are involved, pain is felt along the course of the descending sternal, clavicular and acromial branches ; if the second and third are implicated, pain may be confined to the great auricular and occipital nerves ; if the atlas and axis are affected, the neuralgic pain, if any, follows the occipital branches. 2. Rigidity of the spine is a constant accompaniment of Pott's disease. In the early stages it results from muscular spasm, the object being to fix and immobilize the painful part. If the lower portion of the spine is involved, the back is held stiff and straight, the patient abstaining from all movements which would bend or stretch it. Thus, in order to pick up an object from the floor, the 654 A MANUAL OF SURGERY knees and hips are flexed, and the patient gradually lets himself down with an absolutely rigid back into a sitting or squatting posture ; the body is raised in a similar manner by resting the hands upon the thighs, the patient, as it were, climbing with extended arms up his own legs. In a child rigidity in the dorsi- lumbar region can be demonstrated by laying him on his face, grasping the ankles, and ascertaining the amount of movement of the spine at that region by lifting the legs from the table, and also by moving them from side to side. In a healthy child the legs can be elevated, and the spine bent back in the dorsi- lumbar region, nearly to an angle of sixty degrees ; whilst lateral B Fig. 240. — Diagrams to illustrate Deformities in Spinal Curvature. (After Noble Smith.) In A the result of the bodies falling together to form a wedge-shaped mass is seen in the anterior displacement of the upper half of the spine ; in B the compensatory curves utilized by Nature to maintain the erect posture are indicated ; in C the same process is seen in an exaggerated degree. mobility to the extent of thirty or forty degrees on either side of the median line is obtainable. When caries is present, neither of these movements can be made without including the thorax and dorsal spine. In cervical caries the patient steadies the head, and at the same time raises the shoulders by the help of the trapezius and sterno-mastoid muscles, whilst the chin is often supported by one hand, and the patient twists his whole body in order to look sideways. In the later stages, when repair is taking place, or has occurred, rigidity of the spine is due to osseous ankylosis. After a cure has been established, compensatory^movements of other portions of the spine mask, to a certain degree, the localized rigidity. DISEASES OF THE SPINE 655 3. Deformity, the result of Nature's method of repair by means of osseous ankylosis, is necessarily present in almost all instances, although in a few cases, taken in hand early, it is possible that recovery may occur without it. The amount and character of the deformity depend on a variety of circumstances, and perhaps most of all upon the number of vertebrae affected. Where only two bones are involved, a true angular deformity may result, the body of the upper vertebra being welded to that of the lower, so as to produce a wedge-like mass (Fig. 240, A), the surfaces of which are inclined to one another at an angle ; com- pensatory curves of the spine elsewhere enable the patient to assume the erect posture (Fig. 240, B). In the lumbar region, where the affection is often limited to a part of two vertebrae, there is usually little or no displacement, the disease being limited to the centres of the bones, so that the sides may escape alto- gether, and preserve the integrity of the spinal column ; when a distinct projection of the spine is present, the portion of bone which appears most prominent is the spinous process of the lower of the vertebrae. When a large number of vertebrae are affected, as is common in the dorsal region, the curvature is never angular, but the whole region becomes bent forwards, and ky- photic in type, or even almost rectangular. Owing to the obliquity and length of the spinous processes of the dorsal vertebrae, the projection, even when only two bones are involved, is very considerable ; in the latter case the spinous process of the upper vertebrae, by becoming horizontal, is the more prominent. In the cervical region there is rarely much deformity, owing to the small size of the vertebrae, and to the stunted shape and deep posi- tion of the spinous processes; if, however, Fl <*. 241.— Well-marked several bones are involved, the head may A g\ ^result oTpon's be carried forwards, togethei with the upper Disease. part of the spine. Secondary changes in the shape of the thorax necessarily ac- company the more advanced cases of caries in' the dorsal region, the sternum becoming convex anteriorly so as to compensate for the diminished vertical measurement of the thorax, and the ribs crowded together to such an extent as to almost obliterate the intercostal spaces. The lower floating ribs may, however, retain their normal position, and thus a horizontal groove may be pro- duced corresponding to the line of the tenth rib. In such cases the patient becomes much stunted in grow-th, and dwarfed, con- stituting the typical 'hunchback' (Fig. 241). 4. Abscess is the most serious result of spinal disease, for, owing 656 A MANUAL OF SURGERY to its deep origin, it often attains considerable dimensions before it is recognised or treated, whilst it is usually impossible to deal with the causative lesion in the bones, and if once the cavity is allowed to become septic, an exceedingly grave complication is introduced into the case, which may even determine a fatal issue. The pus collects originally on the anterior aspect of the vertebrae, beneath the anterior common ligament (Fig. 238), which may be stripped from the bones for a considerable distance, owing to the tension within the abscess cavity. It thence finds its way to the sides of the bodies after perforating the ligament, and burrows in various directions, according to the portion of the spine involved. In the cervical region a chronic retropharyngeal abscess is first formed ; it pushes the posterior pharyngeal wall forwards, and may be detected from the mouth as an elastic fluctuating swelling, which, by its size, often leads to some difficulty in swallowing and breathing, whilst oedema of the glottis may be induced. Left to itself, various courses are open to it: 1. The abscess may burst and discharge into the pharynx, the cavity necessarily becoming septic, and the osseous lesion thus aggravated. 2. It may travel downwards behind the oesophagus into the posterior mediastinum, and thence extend in the same direction as abscesses in the dorsal region. 3. More often the pus finds its way to the side of the neck, being guided to the posterior triangle by the prevertebral fascia, behind which it is situated ; less frequently it pierces this fascia, and presents in the anterior triangle. 4. In the lower part of the neck, it may spread under the clavicle into the axilla, being directed by the same fascia, which in this region passes down- wards behind the subclavian trunks, and forms the posterior wall of the sheath of the axillary vessels. In the dorsal region, the abscess starts in the same way in front of the vertebrae, and may thence extend as follows: 1. Most frequently it passes backwards between the vertebral ends of the ribs to form a dorsal abscess, burrowing along the course of the posterior branches of the intercostal nerves and arteries, and forming a fluctuating swelling, 3 or 4 inches from the spinous pro- cesses, with an impulse on coughing. 2. It may extend between the ribs and the parietal pleura along the anterior branches of the intercostal vessels, coming to the surface at the spot where the lateral cutaneous branches are given off. Tuberculous disease of the ribs, leading to caries or necrosis, or even a localized em- pyema, may be induced in such cases. 3. Very rarely the abscess may travel up to the neck, pointing behind the sterno-mastoid muscle. 4. Not uncommonly, however, it works its way down- wards, passing under the ligamentum arcuatum internum of the diaphragm, thus entering the psoas sheath, and giving rise to a psoas abscess. In disease of the dorsi-lumbar or lumbar regions, either a DISEASES OF THE SPINE 657 lumbar or a psoas abscess may result. A lumbar abscess is due to the passage backwards of the pus along the posterior branches of the lumbar vessels and nerves to the outer border of the erector spinae, and usually presents superficially in Petit's triangle — i.e., between the adjacent borders of the latissimus dorsi and external oblique muscles. It there forms a tense fluctuating swelling, with an impulse on coughing. A psoas abscess lies within the sheath of the psoas muscle, the pus being usually superficial to the muscular fibres, some of which are probably destroyed. It passes downwards, giving rise to a fusiform enlargement, deeply placed in the back of the abdomen ; at the brim of the pelvis, it usually burrows outwards under the fascia iliaca to form a tense rounded swelling in the iliac fossa (Fig. 5 ; p. 51). It thence travels under Poupart's ligament, behind and external to the common femoral vessels, being constricted at this spot so as to form a narrow neck. The sack then expands behind the common femoral sheath, the vessels being often displaced forwards, and the vein flattened out and compressed. Thence passing along the tendon of the ilio-psoas, to the neighbourhood of the lesser trochanter, the abscess comes into relation with the internal circumflex artery, and usually points at or near to the saphenous opening to the inner side of the main vessels. It may, however, follow the different branches of the internal circumflex amongst the adductor muscles, forming a large swelling on the inner side of the thigh, displacing these structures, or it may even travel along its main trunk behind the neck of the femur to reach the surface behind the great trochanter. In other rare cases the abscess has been known to extend down the leg, and has even been evacuated by the side of the tendo Achillis. Occasionally, the pus finds its way down into the pelvis instead of passing under Poupart's ligament, and then points in the ischio-rectal fossa, or possibly burrows through the sacro-sciatic foramen. The constitutional disturbance associated with the formation of these abscesses is usually but slight ; perhaps there is a small rise of temperature, but if, as occasionally happens, ordinary pyogenic organisms find their way into the sac from within the body, this may become more marked. As they come to the surface, con- siderable pain may be experienced from the tension and irritation of the soft parts, and fever of a hectic type is induced. 5. Paraplegia is fortunately not a common result in tuberculous caries of the spine, only occurring in the worst or in neglected cases. It is scarcely ever due to the acuteness of the curve. It has been known to result from a fracture of the spine, the integrity of which has been weakened by the inflammatory process, but is usually caused by an extension backwards of the disease, so that a nodule or button of tuberculous material forms beneath the posterior common ligament, or pushes through it, compressing the cord against the laminae, and actually invading the dura 42 658 • A MANUAL OF SURGERY mater. It occasionally originates in the pressure induced by an abscess, which extends backwards into the spinal canal. The effect produced on the cord varies with the rapidity and acuteness of the process. When the pressure is rapidly developed, a subacute myelitis ensues, but more frequently it is of a chronic or sclerosing type. The cord is then found to be constricted or in- dented by the tuberculous mass, and perhaps considerably reduced in size ; its texture is firmer than normal, and the colour grayish. The onset of symptoms may be suddenly induced by haemorrhage or displacement of bone, but is more usually gradual. The dorsal region (about the eighth vertebra) is that most often involved, since there is plenty of space in the cervical region, and in the lumbar the cord has broken up into the cauda equina. Statistics seem to indicate that paraplegic phenomena occur in about one out of every thirteen cases. The symptoms arising from pressure on the cord must be dis- tinguished from those due to irritation of, or pressure on, the nerve roots. The latter causes neuralgic pain along the course of some particular nerve, possibly in the later stages associated with anaesthesia (anesthesia dolorosa), or a limited motor weakness if the anterior roots are involved. In compression of the cord, motor phenomena are more evident than sensory, since the sensory track lies towards the centre of the cord, and so is more protected from injury. At first there is some dragging of the toes on walk- ing, and loss of power in the legs, combined usually with neuralgia, weakness of the sphincters, and exaggeration of the reflexes. Later on the paralysis becomes complete, and, as degeneration of the cord follows, secondary contractions and rigidity occur, and the reflexes diminish. Absolute incontinence sometimes super- venes, the bladder emptying itself periodically and involuntarily, or the urine trickling away continually from either a full or empty viscus. Special mention must be made here of a grave complication only occurring in the upper cervical region, and which may result in sudden death. Tuberculous disease of the upper two vertebrae usually originates in one or more of the large articulations on either side of the atlas ; if these joints become disorganized, displacement may occur at any moment, and in this way the occiput slips forwards upon the atlas, and may lead to gradual or sudden compression of the cord and consequent death. The disease sometimes spreads to the body of the axis, and by this means the odontoid process becomes detached, or the transverse ligament gives way ; in either case, the weight of the head carries the arch of the atlas forwards, and death ensues from compression of the medulla. Course of the Case and Prognosis. — Left to itself, the disease usually progresses more or less steadily, the bone lesion becoming gradually more marked, and abscesses tending to develop. If DISEASES OF THE SPINE 659 treated efficiently, and taken in hand early, repair by ankylosis may be confidently expected. Even when an abscess forms, prolonged rest may lead to its disappearance, the fluid part of the pus being absorbed, and the solid elements becoming in- spissated and dry, forming a putty-like mass lying on the front of the vertebral column ; this may subsequently break down, probably owing to infection with pyogenic cocci, constituting what is known as a residual abscess. Should, however, the abscess burst or be opened, and become septic, symptoms of hectic fever and amyloid disease are almost certain to develop, and the patient is sooner or later exhausted by the discharge, and dies from asthenia. If dealt with judiciously, and sepsis avoided, the abscesses may be cured, and if at the same time the spine is kept at rest, the lesion in the bones is able to con- solidate. The onset of paraplegia, again, must not be looked on as rendering the case hopeless, since with prolonged rest the paralytic phenomena can entirely disappear. Septic cystitis and bedsores often arise as complications, and, if allowed to progress, cause the death of the patient. Occasionally, as a result of the implication of the spinal canal, diffuse meningitis follows, leading to a rapidly fatal termination. As in tuberculous disease else- where, the patient also runs the risk of acute miliary tuber- culosis, whilst other organs, e.g., the lungs, brain, or kidney, may become affected. In spite of these possibilities, however, the prognosis is good as regards life in cases free from complications, and where suitable treatment is practicable. The Diagnosis of spinal caries is never a matter of difficulty when the characteristic deformity exists, but in the early stages, when the displacement is not evident, or if there is only a very slight prominence of the spinous processes, it is likely to be mis- taken for a simple rachitic or statical curve ; whilst if neuralgic pain is a prominent symptom, it may possibly be looked on as a case of spinal or intercostal neuralgia, or as rheumatism, or even be ascribed to renal affections. Tumours of the spine, such as cancer, or hydatid cysts, syphilitic disease, and aneurismal erosion, also produce symptoms somewhat resembling those of spinal caries, and in adults it may be impossible to determine from the local phenomena alone which of these conditions is present, although a careful consideration of the general history and of the onset of the symptoms may throw some light upon the case. Frequently the course of the disease and the reaction to treatment must be mainly relied on in forming a diagnosis. The spine should always be examined from before and from behind, and pain on pressure over the transverse processes and rigidity of the back are the symptoms on which most stress should be laid. The diagnosis of the abscesses connected with spinal caries is sometimes not devoid of difficulty, especially when they point in the groin or the lumbar region, since similar collections of pus 42 — 2 66o A MANUAL OF SURGERY may arise from a variety of other causes. (a) A pevinephritic abscess is recognised by the association or pre-existence of symp- toms of renal disease, whilst a spinal lesion may be absent. Of course, both conditions may be present in the same individual, and the diagnosis can then only be made by an exploration of the abscess cavity, (b) An empyema occasionally points in the loin or even in the groin, but should be recognised by an examination of the thorax, (c) A chronic abscess, due to appendicitis may present very similar signs to those of a deep-seated abscess in the ilio- psoas region on the right side, if it has not extended below Poupart's ligament. Careful examination, however, will demon- strate the upward extension of the abscess towards the spine in the latter case, whilst the previous history will differ consider- ably in the two conditions. The character of the pus is, more- over, a distinctive element, in that it has almost always an offen- sive smell when due to appendicitis, on account of the presence of the Bac. coli com munis, (d) An iliac abscess may arise from a variety of conditions other than spinal disease, e.g., necrosis or caries of the ilium, or cellulitis in the tissues under the fascia iliaca. It is recognised by being, as a rule, more distinctly limited in extent than an ilio- psoas abscess, and by the absence of symptoms of spinal disease, (e) Abscesses arising in connection with hip disease occasionally point in the groin, but are easily distinguished from a psoas abscess by not extending upwards along the course of the psoas muscle, and by the evident signs of hip disease which are always present. (/) Diffused or ruptured aneurism of the iliac artery may give rise to considerable difficulty in diagnosis, since a non-pulsating tumour in the course of the muscle is sometimes produced. The preceding history, the absence of fluctuation, the oedema and congestion of the leg, the interference with the pulse, and the rapid increase of the tumour, should indicate the nature of the case, (g) The diagnosis of abscess from femoral hernia is given elsewhere. Treatment. — The great essential in the treatment of spinal caries is absolute immobilization, perhaps associated with the application of some mechanical support, which takes the weight of the body from the seat of disease. This may be effected in any of the following ways : (a) By the Adoption of the Recumbent Posture. — The patient is kept in bed either in the prone or supine position, until the pain in the back has diminished to such an extent as to warrant the applica- tion of a spinal support. In any but the youngest children the prone position on a suitably constructed couch may be adopted with advantage, since by this means the weight of the body is more completely taken off the spine, whilst local applications, such as blisters, or even the actual cautery, can be made. In many cases it is advisable to combine treatment in this fashion with the application of a removable poroplastic or leather spinal DISEASES OF THE SPINE 66 1 jacket. If thought desirable, extension by weight and pulley attached to the legs, as described at p. 476, may also be employed ; pain and irritation due to the pressure of the diseased bones one on the other are thereby minimized. (b) By the Application of Sayre's Plaster Jacket. — If the disease exists in the dorsal region, the trunk is encased in plaster of Paris, which should extend from the axillae to just below the iliac crests. The patient is stripped to below the waist, and a closely-knitted woollen vest fitted to the body, and fixed by straps passing over the shoulders. A pad or folded towel is placed beneath it over the abdomen to allow for distension after meals, and in women similar smaller pads may be placed over the mammae to protect them. Coarse canvas bandages, into the meshes of which plaster of Paris has been rubbed, are thoroughly soaked in water, to which a little salt may be advantageously added, and then wound evenly round the body until a layer of five or six thicknesses is obtained. Over this a paste of plaster of Paris, prepared as described at p. 430, is laid, until the jacket has attained sufficient thickness and consistency. It is allowed to dry before the patient's posi- tion is altered. In adults, where the disease is chronic and not acute, the jacket should be applied whilst the spine is extended by sus- pending the patient by the head and axillae from a suitably arranged tripod. In children, or when the disease is acute, it will suffice if the parent or an assistant partially supports the patient from the armpits, or the apparatus can even be applied with the child in the recumbent posture. The jacket must be worn until all pain and evidence of active disease have dis- appeared, and after that the patient should be fitted with a poroplastic support for a time. In disease of the cervical or upper dorsal vertebrae, a special jury-mast is required, in order to steady the head and take the weight off the spine (Fig. 242). It consists of an iron rod, fixed to a plaster or poroplastic jacket, accommodating itself to the curves of the head and neck ; above, it extends forwards as far as the vertex, and has attached to its upper end straps, which pass downwards beneath the occiput and under the chin. (c) By the Use of Phelps' Box. — This plan of treatment, which has been advocated by Phelps of New York, consists of a wooden box 6 inches deep, the lower end of which is divided into two portions, one for each leg, a suitable aperture being left at the junction of the divided parts for the passage of the excreta. Careful padding is applied to the whole of the interior, and the Fig 242.— Sayre's Plaster Jacket, with Jury-Mast for Cervical Disease. (Till- MANNS.) 662 A MANUAL OF SURGERY child is strapped and bandaged into this apparatus, and kept there for a period varying from six to twelve months. The whole trunk is thus absolutely immobilized, and the child can be easily carried about in his box, and taken into the open air. Extension can also be made, if necessary, by elastic accumulators attached to the head and neck, or legs. (d) In very young children perhaps the simplest apparatus is a double Thomas's splint, with a suitable crutch above to fix and support the head. During the whole course of treatment, the general condition of the individual must be carefully attended to, and suitable food and tonics administered. Wherever possible, the child should be taken regularly into the open air, or preferably sent to the seaside. When all symptoms of pain and irritation have disappeared, the patient may be allowed gradually to get about again with a mechanical support, and, indeed, this should not be dispensed with for six or eight months after apparently complete recovery. Counter -irritation is but seldom required. It may be useful, however, when severe pain exists in the early stages, especially in adults. The best means to employ is the actual cautery, either applying a button cautery at several spots on each side of the spine, or searing the skin longitudinally. Recently it has been proposed by Calot and others to overcome the deformity of Pott's disease by forcible straightening under an anaesthetic. A considerable number of cases have now been treated in this way, and with a moderate degree of success ; unfortunately many deaths have been the direct result of this procedure, whilst the subsequent immobilization needs to be very prolonged, and the deformity may recur. Personally we consider that although it may be safe and desirable to straighten the back in a few cases, yet the risks are so great and the process so opposed to Nature's method of cure that unless future statistics show much better results than hitherto, the proceeding is scarcely justifiable. The most interesting point observed in this connec- tion is the fact that cases of paraplegia seem to be immensely im- proved by this process, and that within a few days. It is also now maintained that no very great degree of force is required to do all that is desirable ; the patient's head and feet are steadied by assistants making traction, and the surgeon merely uses as much force as can be applied by one hand placed over the curve. The Treatment of the Chronic Abscesses is always a matter of anxiety, since, when once opened, they usually take a considerable time to heal, and if allowed to become septic, the prognosis of the case is seriously affected. A general description of the methods employed has already been given at p. 55. A Retro -pharyngeal Abscess should always be dealt with from the neck, as described in Chapter XXVII. A Dorsal, Lumbar, or Psoas Abscess should be tapped with a DISEASES OF THE SPINE 663 large aseptic trocar and cannula ; after the escape of the pus, the cavity is thoroughly washed out with a mild antiseptic lotion, or with sterilized water at a temperature of 105 to no° F. In the case of a psoas abscess, this irrigation may be combined with gentle massage of the abscess cavity, in order to detach as far as possible the pyogenic membrane, and to assist in the re- moval of curdy debris. When the lotion returns uncoloured, or but slightly tinged with blood, an ounce or two of a 10 per cent, emulsion of iodoform in glycerine is injected, and diffused, if possible, through the abscess cavity by manipulation. The cannula is then withdrawn, and the external wound closed. Occasionally a cure can be obtained in this way by one tapping, but only when no active disease is present, and when the patient's general health is good ; more commonly the fluid will re-collect, and the same process may need to be repeated two or three times. Sometimes the fluid finds its way along the track of the cannula, and a sinus results ; such must be dressed anti- septically until cicatrization has occurred. The best position in which to tap a psoas abscess is at a spot just internal to the anterior superior spine ; a small incision is made in the skin, sufficient to allow of the insertion of the trocar through the abdominal muscles into the cavity of the abscess, but the surgeon must make certain that the intestines have been previously dis- placed to one side. In a large abscess no fear need be entertained on this score, since the parietal peritoneum is always pushed inwards ; but if there is any doubt, the abdominal muscles must be cleanly divided through an incision about 1^ inches long, so as to expose the abscess sac ; a sinus is, however, more likely to form if this is done. Should the abscess point below Poupart's ligament, close to the saphenous opening, it may be necessary to open it there, perhaps in addition to tapping it in the usual place. It must be remembered that the femoral vessels are displaced somewhat and stretched over the sac, and precautions should be taken to prevent puncturing the vein, an accident which has occurred. Some prefer to open the abscess freely, and scrape out its interior with a Barker's flushing gouge. Certainly by this means the tuberculous pyogenic membrane and debris can be more thoroughly removed, but the sharp edge of the instrument is capable of doing a considerable amount of harm in this situation, and there is also more likelihood of a sinus remaining. Personally we are not in favour of its use for this purpose, and maintain that the method which we have advocated above is better, since there is less probability of the wound becoming infected with the tuber- culous material, and hence of the formation of a sinus. Occasionally it may seem advisable to freely open the sac of a psoas abscess, and where the disease originates in the lumbar vertebrae it has been recommended by Sir F. Treves and others to 664 A MANUAL OF SURGERY cut down along the outer border of the erector spinae, and deal with it from behind. A vertical incision is made in this situation, down to the transverse processes, and the lumbar fascia and quadratus lumborum are divided by a transverse cut opposite the tip of one of these ; the abscess sac is then easily reached and opened. The advantage of this plan is that the bodies of the vertebrae can be examined, and even scraped, or sequestra removed. When symptoms of paraplegia arise in the course of Pott's disease, it is usually unnecessary to do more than maintain the immobilization of the spine, since, as already stated, the natural tendency of these cases is towards recovery. At the same time, extra precautions should be adopted in order to prevent bedsores over points of pressure. Should any difficulty in micturition arise, regular catheterism must be adopted, and the greatest care directed to the sterilization of the catheters, septic cystitis being always due to external contamination. In such cases it would be wise to purify the penis and urethra, and to keep the former wrapped in a dry aseptic dressing in the intervals between catheterism. A certain amount of forcible extension may be permitted in these cases, and will probably do good. Laminec- tomy (p. 644) is required in order to relieve pressure upon the cord in the following cases : (a) When septic cystitis or the existence of deep bedsores is threatening life ; (b) when, in spite of prolonged rest, the symptoms persist or increase ; (c) when paraplegic symptoms develop late in the case, and are possibly due to a development of fibro-cicatricial tissue outside the mem- branes (peri-pachymeningitis). (d) Finally, whenever the tuber- culous process mainly affects the neural arches, there is no reason for not treating it by operation, if necessary. III. Syphilitic Disease of the spine develops in the shape of gummata, commencing beneath the periosteum which covers the bodies ; it is of unfrequent occurrence, and gives rise to symptoms exactly similar to those of tuberculous caries, from which, indeed, the condition cannot be diagnosed, except by the history and its reaction to treatment. It usually occurs in adults, and is said to mainly affect the cervical vertebras (Tubby). Suppuration and abscess formation are not commonly observed. The co-existence of a syphilitic history and of specific lesions elsewhere may help one in coming to a decision as to the nature of the affection. Treatment consists in the administration of suitable anti- syphilitic drugs, and in the use of a spinal support. IV. Rheumatic Spondylitis is a condition occasionally met with arising from the same causes, and associated with much the same phenomena as rheumatism elsewhere. It may involve either the ligamentous or muscular tissues, or may attack the intervertebral joints. Any part of the spine is involved, but perhaps the most DISEASES OF THE SPINE 665 marked features are presented in the cervical region. Consider- able impairment in the movements of the head is then produced, and the neck may be laterally deflected, somewhat simulating torticollis. If untreated, adhesions form between the bones, and the loss of movement may be permanent. The treatment is of an ordinary anti-rheumatic nature. The so-called Gonorrhoea! Rheumatism also affects the spine occasionally, and brings about much the same results. V. Osteo-arthritis sometimes attacks the vertebral column, leading to destruction of the intervertebral discs and of the articular cartilages, together with erosion of the bones and the formation of osteophytic masses around. A large portion, if not the whole, of the spine is usually involved by this disease, and a prominent feature is the almost invariable supervention of ankylosis, either from ossification of the anterior or posterior common ligaments, or from interlocking or fusion of osteophytes. A marked kyphosis results, and great pain is present. Finally, the process spreads to the articulations between the ribs and the vertebrae, and when these become fixed the respiratory move- ments are considerably impaired, and hence death is likely to ensue from pulmonary mischief. Treatment is as for similar disease elsewhere. Tumours of the Spine are usually malignant in character, and most com- monly secondary developments of cancer or sarcoma. Simple tumours, such as osteoma and hydatid cysts, do occur, as also primary sarcoma. The chief symptoms are severe and localized pain, which is constant, and unrelieved by rest in the recumbent posture, together with early excurvation and paraplegia. These three phenomena manifesting themselves in an adult should always suggest the presence of a morbid growth. Treatment necessarily is but rarely feasible, although an exploratory operation is quite justifiable if the disease is primary and the patient not profoundly cachectic. Tumours of the Spinal Cord and Membranes develop in several situations, and the symptoms are thereby somewhat modified. (a) Outside the spinal dura. Lipoma and sarcoma are here most often seen, and the symptoms of cord pressure, such as loss of power and sensation, are preceded by those of spinal irritation, e.g., neuralgic pain, increased on movement, and are often limited for some time to one side, (b) They may grow from the inner aspect of the dura mater, and thus produce symptoms of cord pressure and meningeal irritation concurrently. Sarcoma, fibroma and gumma, are the commonest forms of neoplasm in this situation, (c) From the spinal cord itself, myxoma, psammoma, and sarcoma may originate. The symptoms are those of para- plegia combined with some localized and referred pain or tenderness, and usually bilateral from the start. Left to themselves, patienlis suffering from any of these growths are certain to die, and hence an exploratory laminec- tomy, with a view to removal of the growth, if practicable, is always indicated when a diagnosis has been effected. The possibility of the disease being syphilitic in origin must not be overlooked, and hence a preliminary thorough course of iodide of potassium should always be instituted before operating. The results hitherto obtained have been distinctly encouraging, although many of the cases are left till too late, and the mortality is certain to be high. 666 A MANUAL OF SURGERY The only inflammatory disease of the cord which need be alluded to here is one, the results of which have already been mentioned constantly in the chapter dealing with the deformities of the body (Chapter XVI.), viz., Infan- tile Paralysis. This condition is due to an inflammation of the anterior cornua of the grey substance of the cord (anterior poliomyelitis), as a result of which the multipolar ganglion cells situated therein are destroyed. The symptoms come on abruptly, and are often introduced by a short febrile attack ; paratysis shows itself at once, and quickly attains its maximal proportions, being possibly followed by a certain amount of recovery. The portions that remain paralyzed early lose their nutrition, owing to the destruction of their trophic ganglionic centres, and become cold and bluish in colour ; finally, deformities due to the unbalanced action of opposing groups of healthy muscles may appear, whilst the development and growth of the affected limbs are impaired. The distribu- tion of this affection is very variable, but, speaking generally, the legs are most commonly affected, the lower halves, and not the upper, being mainly in- volved ; various forms of talipes may result therefrom, as also weak and flail- like conditions of the knee and ankle. When the thigh is included, the quadriceps extensor and adductors are usually picked out. In the arm the deltoid is most often paralyzed, and after this the muscles on the extensor side- of the forearm, excluding the supinator longus. The face and neck are rarely involved, but the abdominal and back muscles may be attacked. The Treat- ment in the early stages is directed towards improving the general health, and maintaining the nutrition of the affected muscles as far as possible by electricity and friction. In the later stages, when deformed or weak and flail-like limbs have resulted, various means may be adopted in order to improve the functions of the part, (a) Mechanical support is often needed, and this must be carefully regulated, in order to assist, and not to hamper, the movements of the individual by its unnecessary weight. In paralytic talipes, irons fixed to the boots, and rising above the knee, or even sometimes running up to the pelvis, are frequently required, (b) Tenotomy, or division of muscles or fasciae, may also be needed in certain deformities, (c) Tenoplasty, or the grafting of a healthy tendon into a paralyzed one, has been occasionally utilized, as also the transplantation of the bony attachments so as to put the relaxed and weak muscles on the stretch, (it) Arthrodesis, or the fixation of joints, is a useful proceeding under circumstances where the unnatural mobility is difficult to control, or would necessitate considerable increase in the weight of the apparatus required, or where, from the poverty of the patient, the apparatus cannot be obtained. It is especially serviceable in cases where two joints in a limb are flail-like, one of which may then be ankylosed with advantage. The operation consists in a modified excision, the cartilage alone being sawn or scraped from the ends of the bones. (e) Where the whole limb is hopelessly paralyzed and a great inconvenience to the patient, amputation is often the best practice. CHAPTER XXIII. HEAD INJURIES. Injuries of the Scalp. Wounds of the scalp are produced either by sharp or blunt instruments, by falls on the head, or by gunshot injuries. From the tenseness of the scalp over the cranium, it often happens that a blunt weapon, such as a policeman's truncheon, will cause a wound nearly as cleanly cut as if it had been made with a sharp instrument. The depth to which the injury extends is a most important element in these cases, and, so long as it is limited to those parts superficial to the occipito-frontalis aponeurosis, but little harm is done ; if, however, the layer of loose cellular tissue between the aponeurosis and the pericranium is opened up and infected, septic cellulitis (p. 93) is likely to ensue, and fatal conse- quences may result. The superficial extent of the wound is a matter of little moment, since the vascular supply is so good that sloughing is uncommon ; a large portion of the scalp may be torn up and bruised, and yet, if it is carefully washed and rendered aseptic, there is every probability that it will retain its vitality. The Treatment of scalp wounds is conducted on exactly the same lines as that of wounds elsewhere ; that is to say, after efficient purification they may be stitched up, provision being made for drainage, if necessary. The hair should, of course, be cut away from the neighbourhood of the wound, and an antiseptic dressing applied. Haemorrhage from the scalp may be severe, owing to the division of some of the large arterial branches ; it is dealt with according to the general rules of surgery. Contusions of the scalp may occur without solution of continuity of the surface, and results in the formation of bruises or haema- tomata. A similar condition is found in new-born infants ; it is due either to pressure or injury to the head during its passage through the mother's pelvis, or to the compression of obstetric instruments. Three varieties of the so-called cephallunnatoma have been described, viz. : (a) the Superficial, which, confined to the dense subcutaneous tissue, is necessarily small and limited. 668 A MANUAL OF SURGERY (b) The Subaponeurotic, occupying the loose tissue under the aponeurosis, and only limited by the attachments of this structure. It forms a large, soft, fluctuating swelling, upon which the scalp appears to float, bagging down over the eyes or occiput, (c) The Subpericranial is limited by the pericranium dipping down into the sutures around the bone with which it is connected. Most commonly it forms over one of the parietal bones, presenting a soft, fluctuating swelling, which soon gains an indurated margin owing to a deposit of fibrin, and in this condition may simulate a depressed fracture of the skull, inasmuch as the cup-like fluid centre allows the finger to sink in and touch bone below. It is not diffi- cult to recognise, however, since the indurated margin can be readily indented by the finger, whilst the edge is definitely raised above the surface of the cranium, and hence the sensation of depression of bone felt through the fluid is only apparent. In old-standing cases ossification of the walls of this cavity has even been known to occur. Treatment. — All that is required is the application of evaporating lotions. There is hardly ever any need to lay open or drain these swellings. Traumatic Cephal -hydrocele is the name given to a rare condition following head injuries, especially in children. It is characterized by the formation of a fluid swelling under the scalp, which pulsates synchronously with the heart-beat, and has a definite impulse on any expiratory effort ; it varies in size from time to time, and is sometimes partially reducible. It contains cerebro-spinal fluid, and is due to a simple fracture of the vault, laying open either one of the lateral ventricles or the subarachnoid cavity. In one case it was proved on operation to be connected with an arachnoid cyst, due to a localized subarachnoid haemorrhage. Probably it is wise to leave this condition studiously alone, although, if one could be tolerably certain that the ventricle was not affected, it might be laid open and drained. Injuries to the Cranial Bones. Contusions of the Cranial Bones apart from fracture may lead to serious results, i. Many of the inflammatory conditions of bone described elsewhere may be originated ; e.g., if the patient is in a condition of low germicidal power, acute osteomyelitis may follow, associated with pyaemia from thrombosis of the large veins of the diploe ; or chronic sclerosis anfl overgrowth of the bone, local or diffuse, may supervene. Syphilitic or tuberculous manifestations may be similarly lighted up if the patient is the subject of either of these diseases. 2. In addition to such osseous conditions, pus may form within the cranium outside the dura mater [subcranial abscess, p. 690), and necessitate trephin- ing. 3. The dura mater may be detached by a simple contusion, leading to meningeal haemorrhage (p. 68 1). 4. Any of the HEAD INJURIES 669 cerebral lesions detailed hereafter may be produced. Contusions of the cranium must obviously never be treated lightly, even when they are associated with unbroken skin ; much more are they serious when compound, owing to the risks of sepsis. Fractures of the Skull may be described for convenience under the following headings: Fissured Fractures of the Vault ; Fractures of the Base (usually fissured) ; and Depressed or Punctured Fractures. I. Fissured Fractures of the Vault are always due to external violence, direct or indirect. In the former case the skull first yields at the injured spot, but the fissure may extend from it for some distance ; in the latter the fracture results from the yielding of the skull when compressed beyond its natural limits of elasticity. A simple fissure gives rise to no symptoms indicating its pre- sence w T ith certainty. There may be some amount of superficial ecchymosis, but nothing more definite. When compound the line of fracture may be seen as a red streak, or even felt with the finger as an irregular ridge. It consists of a mere longitudinal fissure, or may be starred ; if uncomplicated, it is of but little importance, and needs nothing beyond general treatment — of course, the greatest care being taken to ensure asepsis. Occasionally, how- ever, an osseous growth forms from protuberant callus on the inner aspect of the cranium at the site of fracture, and gives rise to traumatic epilepsy or insanity (p. 703). II. Fractures of the Base of the Skull are almost always fissured, only occasionally punctured or depressed. Causes. — (a) Violence may be directed to the vertex or to some part of the cranial convexity, as from a blow or fall upon a hard substance. There has been a good deal of discussion as to how a fall on the vertex causes fracture of the base. The old idea of contre- coup — i.e., that the force was transmitted from one side of the skull to the other, producing a fracture — may be decently buried and forgotten, whilst two main theories still hold the field, each being probably responsible for a certain number of cases, (i.) Aran's theory of irradiation maintains that a fracture of the base is always due to direct extension of the fissure from the injured vertex, a proposition probably quite true in many cases, but insufficient to explain all. (ii.) A more recent idea, known as the bursting or compression theory, is based on the fact that the cranium is not a solid and totally unimpressionable body, but is highly elastic, as has been proved by the observation that hair and even pieces of skin have been found nipped in a fissured fracture of the vault, which had evidently gaped open and closed again. Severe com- pression necessarily diminishes the diameter of the skull along the axis of greatest pressure, making it bulge in other diameters ; and 670 A MANUAL OF SURGERY it this distension exceeds the limits of elasticity, the bone gives way. The direction of fractures produced in this manner varies. Most commonly the lines of fracture are parallel to the direction of the compressing force, the bone thus bursting open along its convexity (fracture by bursting) ; less frequently it gives way at right angles to the direction of the force where the bulging is greatest (fracture by compression). Inasmuch, however, as the force is transmitted equally in all directions, the weakest part is most likely to give way, viz., the base. It has been pointed out by Felicet that the skull consists of alternate strong and weak parts, the stronger buttresses being formed by the occipital ridges, the petrous bone, the greater and lesser wings of the sphenoid, and the frontal crest, and that consequently fractures are more likely to involve the intervening weaker parts. Whether these ideas are justified is a question ; certainly the figures quoted by Phelps* indicate that irradiation is responsible for a very large proportion of fractures of the base, (b) Direct injury to the base of the skull is undoubtedly the cause of a certain number of fractures, and some of these are depressed, and not fissured, in character. Thus, the point of an umbrella or stick may be thrust through the upper wall of the orbit, or up the nose through the cribriform plate of the ethmoid ; the condyle of the jaw may be driven through the glenoid cavity into the middle fossa by a blow on the chin ; direct injury from a fall or a stab may pene- trate the occipital bone, whilst a gunshot wound in the mouth is another illustration of this kind of injury, (c) The impact or re- sistance of the vertebral column against the occipital condyles produces fractures in the posterior fossa which radiate from the foramen magnum, and may even occasion a ring-shaped fracture around it (Fig. 243). They result from falling on the vertex into a soft mass, e.g., a bale of wool, or by alighting from a height on the heels or nates. The fracture may run in any direction, longitudinal, oblique, transverse, etc., according to the direction of the compressing or fracturing force, and it may affect any part of the base, either being limited to one of the fossae or involving all; it may follow the sutural lines in part, but it is no uncommon thing to see even the dense petrous bone traversed by a fissure (Fig. 244). Naturally, transverse fractures tend to be limited to one of the fossae, whilst a longitudinal fissure may involve them all. Some fractures of the base of the skull are simple in nature, but the majority are compound. In the anterior fossa the fissure extends through the cribriform plate and nasal mucosa, and then lays open the nose ; or a communication may be established with the external air through a penetrating wound in the orbit, or through the ethmoidal or sphenoidal sinuses. In the middle fossa a fracture through the base of the sphenoid opens the roof of the * ' Traumatic Lacerations of the Brain.' London : Henry Kimpton ; 1898. HEAD INJURIES 671 naso-pharynx, or the fracture may involve the tympanic cavity. Tn the posterior fossa the basi-occipital may be broken, and the naso-pharynx again opened, although the fracture here is more commonly simple. Fractures of the base of the skull, though very serious, are by no means necessarily fatal, and, indeed, during the last twenty years or more the results have immensely improved, owing to the use of antiseptic precautions. The main dangers to be apprehended are : (i.) Damage to the base of the brain, including the pons and medulla, especially in cases where the foramen magnum is splintered from the impact of the spine against the condyles ; (ii.) haemorrhage Fig. 243. — Fracture of the Base of the Skull from Force acting against the Occipital Condyles, and producing almost an Annular Fracture around the Foramen Magnum. (Tillmanns.) Fig. 244. — Transverse Frac- ture across the Base of the Skull. arising either from the venous sinuses, or from the meningeal or cerebral arteries ; and (hi.) septic meningitis, due to the fact that the injury not only fractures the bones, but also lays open the dura mater, a grave addition to a compound fracture. The Signs of a fractured base are sometimes exceedingly equivocal, but for convenience may be arranged under four heads : 1. Signs of severe cerebral mischief, such as concussion of the brain and prolonged unconsciousness. This is, however, by no means always present ; thus, in a case we had in hospital a few years back, the patient was capable of going about his work for ten days after the accident. 2. Hemorrhage manifests itself in various directions, according to the situation of the fracture. In the anterior fossa there may be free bleeding from the nose, 672 A MANUAL OF SURGERY owing to the fracture extending through the cribriform plate of the ethmoid ; but a portion of the blood may pass backwards into the pharynx, and, being swallowed, is perhaps subsequently vomited. More often, however, the line of fracture runs across the roof of the orbit, causing escape of blood into the areolar tissue of this cavity. The ecchymosis shows itself as a gradually developing subcutaneous distension, involving the lower lid, bluish- purple in colour at first, but passing later through the other stages of a bruise ; there is probably no contusion of the skin, as in the ordinary black eye, which is at first reddish-purple ; the ocular conjunctiva is considerably involved, but the effusion rarely extends above the cornea, and its posterior limits cannot be seen. The bleeding usually arises from laceration of the dura mater and bone, bnt, when abundant, may come from the cavernous sinus, and the eye may even be pushed forwards (proptosis) ; in some cases pulsation is to be felt within the orbit, and then a traumatic orbital aneurism or aneurismal varix is present. In the middle fossa the blood may enter the nose or mouth, a part being swallowed, but more commonly it escapes from the ears. If abundant, it probably comes from one of the vascular channels at the base of the brain ; but if only slight in amount and of short duration, it may be induced by any of the following lesions, as well as by a fractured base, viz. : (a) A simple rupture of the membrana tympani ; (b) separation of the cartilage of the pinna, with tearing of the lining of the external meatus; (c) fracture of the anterior and lower part of the tympanic plate, as by a blow on the jaw, which drives the condyle forcibly against it. In the posterior fossa the bleeding is usually subcutaneous, show- ing itself around the mastoid process, and extending downwards amongst the muscles at the back of the neck. 3. Discharge of cerebrospinal fluid is an indication that a com- munication exists with the subdural space. The fluid may be discharged from one or both ears, but has also been met with coming from the nose or cranial vault ; when from the ear, the dura mater has probably been laid open through the prolongation which accompanies the auditory nerve in the internal meatus by a fracture traversing the petrous bone. It is watery and limpid in character, with a specific gravity of about 1005, slightly alkaline, and containing a fair quantity of chloride of sodium, with traces of albumen, and of a substance known as pyrocatechin, which, like grape-sugar, reduces cupric salts on boiling. At first it may be slightly blood-stained, but this soon ceases, the fluid becoming quite clear. The amount discharged may be small, but not un- frequently it comes away in large quantities, soaking the pillow and dressings, and, indeed, can sometimes be caught in a test-tube as it trickles from the meatus. As a rule, the flow commences soon after the injury, and quickly ceases ; but a few years back a curious case occcured, under the care of Lord Lister at King's HEAD INJURIES 673 College Hospital, of a man who had fallen backwards off a high bed upon his occiput ; he was temporarily stunned, but returned to bed, and, on awaking the next morning, found that both eyes were black. He continued work for some days, complaining, however, of headache, and at the end of that time of earache, which grew steadiiy worse, until relieved by something giving way in his left ear. This was followed by a copious discharge of cerebro-spinal fluid, which was maintained for some time, and from the after-history there can be no doubt that it was due to a fractured base. Escape of brain substance from the ear has also occurred in a ' few instances, most of them fatal. 4. Lesions of the nerves issuing from the base of the skull are occasionally produced. For symptoms, etc., see Chapter XIII. The nerve most commonly involved is the facial, as it passes through the aqueductus Fallopii ; the paralysis may develop either immediately, or more often about the second or third week after the injury, disappearing in about a month, and then evidently due to its implication in the callus. A certain amount of deafness is often associated with it from injury to the portio mollis. The Prognosis of fractured base has much improved during recent years, as a result of the application of antiseptics to the auditory meatus, thereby preventing the occurrence of sepsis within the meninges. If the patient escapes death from cerebral complications, the bones of the skull unite raqidly, and a good result may be expected, although troublesome sequelae may follow, from the injury sustained by nerves or vessels, or their compres- sion in callus or new bone. Treatment. — Seeing that the chief danger to the patient arises from septic contamination of the meninges, the greatest care must be directed towards preventing decomposition of the discharges. Unfortunately, it is impossible to apply dressings to the naso- pharynx, or even to thoroughly wash it out with antiseptics, and the only satisfaction about such cases is that the rarity of the loss of cerebro-spinal fluid suggests that the membranes of the brain are not very often damaged in that situation, whilst it has also been shown that in the majority of cases the upper part of the nasal cavity is aseptic (St. Clair Thomson). With the ear, how- ever, things are very different ; the meatus should be well syringed with carbolic lotion (1 in 20), and plugged with some efficient dressing, a large pad of the same being bandaged over the affected side of the head. This must be replaced as often as necessary. Beyond this, the treatment of fractured base is directed to the cerebral condition, and does not differ from that usually applied to head injuries, viz., cold to the shaved head (preferably by means of Leiter's tubes), a smart calomel purge to start with, low diet, and absolute quiet in a dark room. The patient should be kept from going about his work for at least six weeks. 43 674 A MANUAL OF SURGERY III. Depressed and Punctured Fractures usually involve the vault of the cranium, and are due to direct violence, either from a fall or blow, causing a simple or compound fracture, or from a penetrating injury occasioning a punctured fracture. In both cases there is often a considerable amount of comminution. It is quite possible for the outer table to be broken and depressed, without any injury to the inner, where an air cavity exists in the bone, or if the diploe is very thick ; thus, the bone may be driven in over the frontal sinus without injury to its inner wall, or the mastoid may be similarly affected. The inner table has also been broken, and fragments even separated, as a result of a simple depression without fracture of the outer table ; this rarely occurs in adults, but is not uncommon in children. Amongst the latter, it is also possible for a considerable depression to exist without any fracture even of the inner table. More usually both inner and outer tables are involved, and when such is due to force reaching it from without, the inner table is always more damaged than the outer, especially in the punctured variety (Fig. 245, A and B). When, however, the force is applied from within, as by a bullet which has traversed the brain, the outer table suffers more than the inner. The causes of this condition are similar, from whichever side the force comes ; we shall, however, only discuss the case of a wound coming from without, (a) The inner table is less supported than the cuter, having merely the soft brain and dura mater within, and hence is extensively splintered, just as a nail driven through an unsupported piece of wood causes ripping up of its under surface, (b) The loss of momentum of the fracturing body will assist this ; the greater the momentum of a bullet, the more cleanly it cuts, a smaller momentum breaking or splintering rather than cutting ; of course, a considerable amount of force is expended in penetrating the outer table, (c) The debris caused by the injury to the outer table will add to the bulk of the penetrating body, and its wedge-like action still further increases the injury to the inner table, (d) All force tends to radiate and diffuse itself from the spot struck, and hence, if the outer table is first injured, the force will be dis- seminated over a much wider area of the inner. The Symptoms and Signs arising from a depressed fracture vary widely in their nature, and are partly due to the injury inflicted on the bone, partly to that sustained by the brain, whilst the septicity or not of the wound is of the gravest significance. Locally, when an external wound is present, one sees blood or cerebro-spinal fluid escaping, or even brain-substance protruding. The damage to the bone may be seen or felt, and the extent of the depression or comminution ascertained. When there is no external wound, a hematoma of variable size forms under the scalp, more or less obscuring the fracture. The character of the lesion is a matter of considerable importance from a prognostic HEAD INJURIES 675 point of view. When the bone shelves evenly in all directions, a pond or saucer fracture is said to be present, and such is tolerably Fig. 245. — Depressed Fracture of Skull seen from Without and from Within. (From Specimen in King's College Museum.) amenable to treatment ; when, however, the depression is sudden and complete, the detached portion lying below the level of the 43— 2 676 A MANUAL OF SURGERY rest of the bone, it is termed a gutter fracture, and the prognosis is increasingly grave. The two forms are, however, often associated. Necessarily, considerable variations are met with in this type of fracture, according to the nature of the injury and the means by which it was inflicted. Thus, if it is due to a fall on the vertex, there is often a ragged, irregular scalp-wound, through which the depression can be seen or felt ; if caused by the puncture of a sharp tool, such as a pickaxe, there is only a small external opening corresponding to the hole in the skull, in which the point of the instrument may be found embedded. A slicing cut with a sabre or hatchet produces a clean incision through the scalp, together with a linear groove in the skull, perhaps somewhat bevelled, which may or may not penetrate its whole thickness. Sometimes detached portions of the skull are raised above their ordinary level, constituting an elevated fracture ; it is usually associated with depression of surrounding parts. Gunshot injuries of the skull manifest any degree of severity, according to the velocity and angle of incidence of the projectile. A non-penetrating wound produces either a severe localized con- tusion or a depression with or without comminution. Jf a modern conical bullet, travelling at a high rate of speed, strikes the skull, it will probably penetrate, and possibly may traverse both sides and thus escape, doing comparatively little harm, except along its immediate track. If, however, the bullet is of an expanding type, or fired from close at hand, considerable additional mischief in the shape of fissures extending widely through the skull is induced. It has been known for some time, and the point has been empha- sized by Professor Horsley, that if a bullet traverses a dry and empty skull, but little harm results, except the formation of the two openings where the bullet entered and left the cavity, and these with the modern weapon are small. If, however, the skull is first filled with damp sand or with water, or if the brain is left in situ, and a bullet fired through it, the effects are much more serious, varying directly with the viscosity of the contents ; such a result is evidently due to the momentum of the penetrating body being transmitted to the molecules of water or brain substance, and thence spreading explosive-like in all directions. Not only does this radiation of the force affect the skull, but the most grave consequences to the brain itself ensue from the displacement of cerebro-spinal fluid, inducing increased pressure upon the centres grouped around the fourth ventricle, and leading primarily to a cessation of respiration. Thus, a bullet fired through the skull and brain of a living dog caused the breathing to stop, although the heart still continued to beat ; by performing artificial respira- tion for a time, natural breathing was re-established. In a simple depressed fracture the patient usually suffers from concussion, followed almost immediately by compression, the latter due in part to the depressed bone, but mainly to exudation HEAD INJURIES 677 of blood and bruising of the brain, and if this is at all extensive and remains unrelieved a fatal result follows almost immediately. Where, however, the depression is but slight, the symptoms of compression may be absent or not marked, and the patient recovers, perhaps to become the subject of traumatic epilepsy or insanity at a later date, induced by the irritation of the dura mater and of the subjacent cortex. If the depressed fragments irritate the motor area, convulsions, spasms, or paralysis may be thereby induced. In a compound depressed or punctured fracture the immediate effects are not necessarily severe, the patient perhaps not even suffering from concussion, though brain substance presents in the wound ; the more limited the spot injured, the less the concussion. The explanation of this fact is that the blow has expended its force in fracturing the cranium, and hence does little harm to the brain, in the same way that a watch may receive but slight damage from a fall if the glass is broken, whilst if the latter remains intact the works are liable to suffer. Left to itself, such a fracture is sure to become septic, and inflammation of the bone, brain, or membranes will follow. Septic osteitis leads to necrosis of the fragments, which may be seen lying dead and yellow at the bottom of the wound, whilst the inflammation may either spread along the diploe to the surround- ing bone, causing extensive necrosis with pyaemia, or between the bone and the dura mater, leading to a subcranial abscess. When once the dura mater has been penetrated, inflammation is liable to spread to the meninges, and then a diffuse or localized suppurative meningitis, accompanied or not with a localized suppuration of the brain, will ensue. Even if the dura mater has not been opened by the injury, the irritation of depressed spicules of bone and the presence of a septic exudation often lead to its ulceration at a later date. If there is a free external open- ing, allowing a ready exit to the discharge, and thus preventing tension, the process may be quite limited, and compression of the brain or diffuse septic meningitis is avoided ; but if the bones are locked together as well as depressed, and the external wound is small, retention of inflammatory products may lead to their diffusion, and the symptoms of compression will soon become evident. A hernia cerebri may also form subsequently. When the fragments of depressed bone are early removed, even if perfect asepsis is not attained, the patient has a good chance of recovery ; whilst laceration of the dura need not result in meningitis, since the opening in the subdural space can be shut off by adhesions of the arachnoid in a very short time. When an aseptic condition of the wound is obtained by early interference, and depressed fragments of bone are successfully elevated or removed, the prognosis becomes much better, and the 678 A MANUAL OF SURGERY case may run an uncomplicated course towards recovery, unless some deeper cerebral lesion co-exists. The Treatment of these cases has been much changed by the introduction of antiseptics, the opinion now prevalent being that a patient runs greater risks from leaving a slight depression unrelieved than by making even what may prove to be an un- necessary exploration with the trephine. We may, therefore, epitomize the treatment thus : (i.) In all punctured fractures, operate. (ii.) In all compound depressed fractures, operate. (iii.) In simple depressed fractures : In adults, always operate ; in children, if gutter-shaped, operate ; if pond-shaped, wait for symptoms, unless the fracture is a bad one. Fig. 246. — Instruments used in Trephining for or Elevating 4 De- pressed Fracture, including Trephine, Elevator, and Hey : s Saw (Down Brothers.) The most debatable of these propositions is that relating to the simple depressed fracture in an adult. It may be objected that many such cases have recovered without operation, and that therefore in shallow depressions one should wait for symptoms ; but whilst admitting the fact, we recall cases where the neglect of such treatment has led to serious trouble, and we have been called on not unfrequently to trephine for traumatic epilepsy due to this very type of injury. The operation is so slight, and the risk so insignificant when asepsis is maintained, that the patient should be given the benefit of an exploration, especially since one can never be certain of the amount of injury sustained by the inner table. When an operation has once been decided on, the sooner it is undertaken the better. The scalp should be shaved and HEAD INJURIES 679 thoroughly purified. An anaesthetic may or may not be given, according to the condition of the patient. In a simple depressed fracture the surgeon should never incise the skin directly over the wound, but should turn down a flap to avoid the presence of a cicatrix over the lesion in the bone. Having cleared away blood-clot and exposed the frac- ture, if there is no projecting margin of bone he will have to trephine, placing the centre-pin upon some firm undepressed bone as near the edge of the wound as possible (Fig. 247). An elevator can now be intro- duced, the fragments prised up into position, and the condition of the inner table investigated. The opening in the skull may be enlarged by cutting pliers or a Hey's saw, but all the bony tissue taken away during the operation should be kept in warm boracic lotion, or, better still, in warm saline solution or blood serum, if obtainable. When the loss of substance is small, there is no need to replace the fragments ; but when it is of considerable size, it is wise to attempt this, wedging them accurately together, so that none lie loose in the wound. An opening for drainage may be left between them, if need be. In other cases they may be chipped up into small pieces and powdered over the wound. In a compound depressed fracture, the skin-wound may be enlarged, or a flap turned down, and the bone dealt with according to circumstances. It may suffice to saw off a portion of a pro- jecting fragment, so as to allow entrance to the elevator, or it may be necessary to trephine. In these cases, the fragments of bone removed must be well purified in warm carbolic lotion (1 in 40) before being placed in the saline solution. The brain and membranes will need careful purification if wounded, and this may be accomplished without fear by washing with a 5 per cent, carbolic solution. Protruding brain substance may be removed, and the dura mater lightly stitched across the gap ; the bones may then be replaced, but room must be left for a drainage- tube to pass within the dura to carry away any fresh effusion ; it Fig. 247. — Punctured of Skull, showing Fracture Spot for Application of Trephine. 6So A MANUAL OF SURGERY may be removed in forty-eight hours, if the case progresses satis- factorily. In a punctured fracture, although the opening in the bone may be small, a large circle is removed, since the inner table is almost always extensively damaged. The centre-pin should rest on sound bone, as near the opening as possible (Fig. 247), and care must be taken to include all depressed fissures in the field of operation. In all cases the patients should be confined to bed with the head low, and the general rules suitable to head injuries followed. It is by no means certain that elevation of the depressed bone will relieve the symptoms, as they may be due to haemorrhagic effusion into the brain which cannot be reached. For treatment of gunshot injuries of the skull, see pp. 205 and 698. Injuries to the Intracranial Bloodvessels. 1. Wounds of the Venous Sinuses are by no means uncommon, being torn across in fractures, or punctured either by some sharp instrument, or by spicules of bone. The superior longi- tudinal, petrosal, lateral, and cavernous sinuses are those most frequently involved, especially the first, because it is more inti- mately connected with the bones than any of the others. When there is no external wound, and only the outer wall of the sinus has been opened, the haemorrhage, if at all severe, will strip up the dura mater and compress the brain, producing effects resembling those due to meningeal haemorrhage, but slower in their onset, and less severe in their course ; if the wound is small, the bleeding is not so great, since comparatively little pressure suffices to arrest it by flattening the sinus against the bone, or the hole may be filled by the spicule of bone, and bleeding does not occur till it is displaced. If, however, the inner wall of the sinus is torn across-, the blood finds its way between the meninges, and gives rise to the symptoms of diffuse intra-meningeal haemor- rhage. When an external wound exists, there is the usual evidence of venous bleeding, but it is readily checked and rarely fatal. Septic thrombosis and pyaemia are the chief dangers, but entrance of air has also led to a fatal issue in a few cases. Treatment, when practicable, consists in plugging the sinus with aseptic gauze, and applying an antiseptic compress, possibly re- moving fragments of bone in order to expose it. Where the outer wall alone has been torn, it may be possible to suture it without interfering with its continuity. For symptoms and treatment of septic thrombosis, see p. 694. 2. Wounds of the Middle Meningeal Artery. — This vessel, which enters the skull at the foramen spinosum, and subsequently divides HEAD INJURIES 68 1 into two branches which ramify between the skull and the dura mater, is occasionally ruptured, with or without a fracture of the skull. The anterior branch is most frequently injured as it crosses the anteroinferior angle of the parietal bone, as the result of a fissured frac- ture ; but it is very liable to be torn by a punctured wound, since the bone is very thin in that locality, or by a depressed fracture. The artery is, however, sometimes ruptured by a blow on the side of the head, sufficiently severe to detach the dura mater, but without causing any injury to the bone ; this membrane always carries the vessel with it, and if it emerges from a bony canal just at that spot, as so often happens, the artery is torn across by the projecting inner lip . jf j & f Fig. 248.— Meningeal Hemorrhage. ot the canal. Whether (From Specimen in College of Sur- or not the dura is geons' Museum.) primarily detached, the blood soon collects between it and the bone, pressing the brain inwards, and burrowing down towards the base of the skull (Fig. 248). Such is due mainly to the force-pump-like action of the arterial pressure, for when fluid is driven into a closed cavity, the power of the jet is multiplied by the area occupied. The clot rarely measures more than 4 inches in diameter. The posterior division is only wounded in about 5 to 10 per cent, of the cases. The Symptoms are, unfortunately, often obscured by some co- existent cerebral lesion or complication : but in a typical case three stages should be present, viz. : (a) A primary concussion, as the result of the blow ; (b) a temporary return to conscious- ness ; and (c) the gradual supervention of coma within twenty- four hours, and that usually without any considerable rise of temperature. The interval of consciousness varies widely, but is not often longer than an hour or two, whilst in many cases it is scarcely recognisable. As accessory signs, the following may be mentioned : (a) Since the blod-clot is situated close to the motor area of the cortex, and especially over the centres for the head and arm, twitching of these parts, followed perhaps by paralysis, may be a well-marked feature, and usually supervenes before the 682 A MANUAL OF SURGERY onset of coma ; (b) when the clot extends to the base of the skull, it presses on the cavernous sinus, and may induce passive con- gestion of the eyeball, paresis of some of the ocular muscles, and proptosis, with possibly a dilated pupil and high temperature ; and (c) when a fissure exists in the bone, blood may filter through into the temporal fossa, and cause a marked fulness in that region. The Prognosis is extremely unfavourable, von Bergmann stating that out of ninety-nine cases only sixteen recovered. The Diagnosis of subcranial haemorrhage is easy if there is an open wound, or if the symptoms are at all typical ; but even then one cannot be certain that the middle meningeal artery has given way, and that the symptoms are not due to venous bleeding. An examination of the injury and of the part struck, and the rapidity of onset of the symptoms, may help in this matter, but it is often impossible to make a diagnosis with certainty. The Treatment consists in trephining in order to remove the blood-clot and secure the artery, if still bleeding. The spot selected for dealing with the anterior division of the artery is i|- inches behind the external angular process of the frontal bone, and 1 1 inches above the zygoma (Fig. 295, F), and this point should be marked on the bone with a bradawl through the scalp before commencing the operation. The scalp is shaved and thoroughly purified, and a flap turned down, including everything as far as the pericranium (Fig. 72, E). A crucial incision is then made over the selected spot, and the pericranium reflected sufficiently to allow a i-inch trephine to be applied. On removing the disc of bone, a mass of blood-clot presents, which should be broken up with the finger and washed away. If the artery is seen bleeding on the dura mater, it may be possible to pick it up, and tie or twist it, or a fine curved needle threaded with catgut may be passed under it, and thus a ligature applied. If, how- ever, the blood comes from a canal in the bone, the outer table must be clipped away, sufficiently to enable the canal to be seen and plugged by a small piece of aseptic wax, sponge, or gauze, which may be left without danger. The flap is then replaced, and stitched down, a drain-tube being inserted for a time. The posterior branch of the artery can be reached by trephining immediately below the parietal eminence at the same level as for the anterior branch — i.e., 1^ inches above Reid's base line ; or, again, it can be exposed nearer its origin at a spot if inches behind the external angular process of the frontal bone, and f inch above the upper margin of the zygoma (Fig. 295, G). 3. Wounds of the Internal Carotid Artery, in its intracranial portion, are rare, but if complete are necessarily fatal. They usually result from penetrating wounds of the orbit, or from a gunshot wound, or the vessel may be torn by a splinter of bone in a fracture of the base of the skull. Mere fissures through the HEAD INJURIES 683 carotid canal do little harm, since there is plenty of room within it around the artery. Occasionally, however, the artery is slightly torn, and an aneurismal varix develops between it and the cavernous sinus. Of seventy-five cases of pulsating exophthalmos, Riving- ton found that forty-one were caused by trauma, and were prob- ably of this nature. Treatment. — -The injury is fatal in the majority of cases before help can be obtained ; if not, compres- sion or ligature of the carotid trunk in the neck is the only hope. See also on intraorbital aneurism (p. 275). 4. Intrameningeal Haemorrhage arises from wounds of the cerebral cortex or membranes in cases of fractured skull, or from concussion without fracture. The blood may be derived from the veins and capillaries so abundantly present in the pia mater, or from lesions of the inner wall of venous sinuses, or even from the middle meningeal artery, if the dura mater is also opened. It may be widely diffused over the surface of the hemispheres, or be more localized. It is often but slowly absorbed, and may become encapsuled, constituting what is known as an arachnoid cyst — i.e., a closed cavity containing serum, the wails of which are formed of fibrous tissue stained brown with haematin. The Symptoms are those of cerebral compression, and usually supervene directly on concussion without any conscious interval. The coma is often of long duration, though, as a rule, not of great intensity. Perfect recovery may ensue, even though unconscious- ness is prolonged for weeks ; but adhesions may form as the result of a chronic meningitis lighted up by the accident, and these may lead to subsequent trouble. No focal symptoms are produced unless the haemorrhage arises from or presses upon the motor area, when convulsions, or later on paralysis, may ensue. The Treatment is symptomatic, the patient being kept absolutely quiet, and all excitement and noise which might induce cerebral congestion excluded. Should there be any focal symptoms indicating the position of greatest pressure, or should there be some concurrent lesion of the skull, the trephine may be applied at this spot. It must not be forgotten, however, that the chief haemorrhage often occurs (as will be presently pointed out), not at the point to which the injury was directed, but at an exactly opposite spot on the other side of the cranium, and hence con- siderable uncertainty may arise both as to the advisability of an operation and as to its site. Should the right locality have been exposed, the dura mater will probably bulge into the wound, after the circle of bone has been removed; it is blackish blue in colour, owing to the clot lying beneath it, and the cerebral pulsa- tions will not be detected. It is carefully incised, and the blood- clot removed ; any bleeding-points should be tied or compressed, or it may be necessary to insert a small wick of aseptic gauze for a day or two, in order to drain off serum and blood. 634 A MANUAL OF SURGERY 5. Cerebral Haemorrhage occurs more frequently from idiopathic causes than from trauma, except in the case of severe lacerations. In the more aggravated forms, death is almost certain to follow in a short time from coma ; the symptoms of the less serious cases are discussed later on under the heading ' Laceration of the Brain ' (p. 694). General Conditions of the Brain after Head Injuries. Concussion of the Brain, or stunning, is a clinical condition characterized by a more or less complete suspension of its func- tions as a result of an injury to the head, which may or may not have produced an anatomical lesion. It varies with the severity of the cause from a slight momentary giddiness and confusion of thought to the most complete insensibility, and is closely allied to shock, from which it is often distinguished with difficulty. In fatal cases, one finds on post-mortem examination merely the same conditions as obtain in shock, viz., engorgement of the lungs, viscera, and the right side of the heart, whilst the brain presents some lesion of varying severity, from mere punctiform ecchymoses to actual disintegration and disorganization. The symptoms are supposed to be due to a paralysis of the vaso- motor centres in the medulla and subsequent loss of vascular tone, allowing the blood to gravitate to the most distensile parts, viz., the portal system. Reflex inhibition of the heart through the vagus may also assist in their production. More recently Duret has suggested that the blow on the skull causes a tem- porary depression, and this leads to compression of a cone-shaped area of the brain substance. As a result, the cerebro-spinal fluid is displaced and forced downwards to the base of the skull, where it tends to collect, particularly in the fourth ventricle, and thus the vital centres grouped around this space are compressed, and anaemia of the brain (which all authorities admit to be present) is produced. This explanation of concussion is very feasible. The Symptoms vary considerably in degree, but in a well-marked case the stage of concussion is evidenced by unconsciousness, more or less complete, although the patient can sometimes be roused by shouting ; he lies on his back, with the muscles relaxed and flaccid ; the eyelids are closed, and the conjunctivae may be insensitive ; the pupils vary, but are equal and often contracted, usually reacting to light, but in bad cases they are dilated, and do not contract when light is admitted. The surface of the body is pale, cold, and clammy, and in bad cases insensitive even to strong electric shocks. The respirations are slow, shallow, and sighing, whilst the pulse is weak, fluttering, and scarcely sensible to the fingers ; the temperature is subnormal ; the sphincters are relaxed, with perhaps unconscious evacuations from both bladder and bowel. The reflexes are present in the milder cases, though sluggish ; in the more severe they may be entirely absent. HEAD INJURIES 685 This condition may last for a considerable time, and then pass slowly into more profound unconsciousness and death, or be followed by the phenomena of inflammation, compression, or cerebral irritation. If, however, the case is going on to recovery, reaction soon begins to manifest itself. The patient is presumably put to bed, and warmth carefully applied to the extremities. The first sign of reaction is probably a slightly increased rate of both breathing and pulse, whilst he may be able to tell his name and address ; sometimes the earliest indication of recovery is that he turns on his side, and pulls the bedclothes up to his face, since he feels cold and chilly as a result of the cutaneous anaemia. Gradually he becomes more and more rational, and the functions of both mind and body are restored, reaction being fully estab- lished by the occurrence of vomiting, due to a condition of cerebral hyperaemia following the anaemia. Probably he suffers from headache for some days, and a slight amount of fever will follow ; but this passes off, and leaves the patient either quite well, or with a somewhat irritable brain requiring prolonged rest. Subse- quent events may, however, prove that more mischief has been done than appears at first. One sequela of concussion may be that some special function of the brain is permanently lost or impaired, such as memory, hearing, or vision ; thus, a patient may forget the names of places or persons, or may lose all memory of time ; speech may become defective or stammering, or a certain amount of asthenopia (weakness of vision) may supervene. Such individuals are very liable to recurrent attacks of inflammation, one of which may prove fatal. Others are left with an in- ordinately irritable brain, incapable of standing excess of work or errors of diet ; and, in such, a sudden fatal issue is not uncommon, Others, again, seem to suffer from a general loss of nerve tone (neurasthenia), rendering them incapable of fulfilling their ordinary duties in life. The Treatment of concussion very closely resembles that of shock, viz., the patient is at once put to bed, with the head low, and is covered with warm blankets ; hot -water bottles may be applied to the extremities, and friction to the surface. Any need- less stimulation must be avoided for fear of exciting haemorrhage ; an enema of hot coffee may be given, or, if in extremis, brandy, or a hypodermic injection of strychnine. On the establishment of reaction, but not before, a good purge, such as 5 grains of calomel, should be administered, and the patient is then kept for some days in bed on a restricted diet, with the bowels freely open and all sources of excitement excluded. When the unconsciousness is prolonged, and the absence of signs of fracture in the cranium or of focal symptoms prevents the localizing of the lesion, the head should be shaved, and an icebag or Leiter's tubes applied ; the bowels are kept acting freely, and the state of the bladder attended to ; the room must be kept 686 A MANUAL OF SURGERY dark and quiet, the attendants making as little noise in walking and talking, etc., as possible ; sufficient nourishment must be given, either by a spoon, if the patient can thus take it, or by nutrient enemata. In the former case iced milk and chicken broth or beef- tea must be depended upon. Cerebral Irritation. — By cerebral irritation is meant a clinical condition which sometimes follows concussion, characterized by great irritability of both mind and body. It usually results from blows or falls on the temple, forehead, or occiput, and is probably due to a superficial laceration of the brain, possibly in the frontal region, and the hyperaemia caused by its subsequent repair. The Symptoms are very characteristic, and usually manifest themselves two or three days after the injury. They may be divided into two groups, (a) Bodily Symptoms : The patient lies on his side in a condition of general flexion, the back arched, the legs drawn up to his abdomen with the knees bent, and the hands and arms drawn in. He is restless, and may toss about, but never fully extends himself, or lies supine. The eyes are closely shut, and he resists all attempts to open them ; the pupils are contracted ; the temperature is usually a little raised, but the surface of the body and head are both cool ; the pulse is quiet but weak ; the sphincters are usually in a normal condition, and the excreta are often passed in the bed, but the bladder may occasionally need to be emptied by catheter. In some mild instances the patient may get up to empty his bladder and then return to bed. (b) Mental Condition : The patient is by no means unconscious, but he takes no heed of what is passing around, and is intensely and morbidly irritable. When disturbed, he will gnash his teeth, frown, swear, and resent the intrusion in the most expressive manner. At the end of a few days, or perhaps after a week or two, a marked alteration in the condition of the patient usually shows itself. He is less irritable, begins to stretch himself out, and with this is conjoined an improvement in both pulse and temperature. A change is sometimes noticed in his mental state, since he may be quite childish and weak. ' Irritability gives way to fatuity' (Erichsen). In this stage he may need to be treated as a child, and even taught the names of persons and things ; later on he may glibly detail the history and cause of his accident, giving a fresh story every day, but frequently there is an absolute lapse of memory concerning the accident and the events which led to it. After a time the brain recovers, but more or less serious after-effects are likely to ensue. Sometimes the symptoms pass over, however, into those of subacute or chronic meningitis. In the Treatment the surgeon must remember that there is a considerable tendency to asthenia, and hence, while the patient is kept quiet and free from all noise or excitement, he must be well supported by a light and nourishing diet. The head should be HEAD INJURIES 687 placed low and shaved, and Leiter's tubes fitted on, if the patient will permit it ; but it is better to omit this entirely than to apply cold intermittently. The bowels must be kept well open, and possibly small doses of bromides, or even opium, may be useful. If any signs of meningeal inflammation follow, such as rise of temperature and pulse, heat of head, and great sleeplessness, blisters or leeches may be applied locally, and mercury ad- ministered internally. Compression of the Brain. — Compression is the term given to a clinical condition due to some abnormal and excessive intra- cranial pressure which disturbs the functions of the brain. When of traumatic origin, it may arise from the following causes : (a) Depressed bone or the presence of a foreign body, in which case the symptoms of concussion merge directly into those of compression, and usually without any interval of consciousness. (b) Extravasation of blood within the cranium, either outside the membranes, or on the surface of the brain, or within its substance. If the bleeding is extradural, there will probably be a short interval of consciousness between the concussion and the com- pression ; if the bleeding is cerebral, the symptoms of compression may manifest themselves at once without any interval being noticed, (c) It may be due to an acute spreading oedema, the explanation of which is subsequently given (p. 695). (d) It may arise from a collection of inflammatory exudation or pus, in which case the symptoms are preceded by those of inflammation, and at the earliest will not manifest themselves before the third day, whilst they may be deferred for a week or two. Compression may also arise as a result of idiopathic haemorrhage, tumours, gummata, or abscesses, e.g., as a complication of middle- ear disease. The Symptoms of compression are essentially those of coma. When the condition is w r ell established, the patient lies on his back absolutely unconscious, and cannot be roused either by shouting or shaking. His breathing is slow, laboured, and ster- torous, the lips and cheeks being puffed in and out. The stertor arises from paralysis of the soft palate, and the puffing of the cheeks from paralysis of the facial muscles. In the later stages the respirations may be more rapid and irregular, somewhat approaching the Cheyne-Stokes type. Death arises from cessa- tion of the respiratory act. The pulse is full and slow at first, but later on becomes rapid and irregular, owing to increased pressure upon and exhaustion of the medullary centres. The surface of the body may either be cool, hot, or perspiring ; the body temperature similarly varies, in some cases being hyper- pyrexial, in others low, and where the compressing force is unilateral, there may be some difference on the two sides of the body. The pupils become dilated without responding to light, 688 A MANUAL OF SURGERY but vary according to the degree of compression and the situation of the compressing agent. If the cerebral pressure is equally diffused, both pupils first contract, and then gradually dilate and become reactionless ; but if one hemisphere is affected more than the other, the pupil on that side passes rapidly through these changes, whilst on the opposite side they are not developed until later. Thus, it is a common thing to find the pupils unequal in size, and reacting differently to light. The whole body in the later stages is in a condition of motor paralysis, but at an earlier period of the case there may be some difference on the two sides, if the lesion is unilateral ; thus, if the left side of the brain is primarily affected, a right-sided hemiplegia is likely to be present at a time when the muscles on the left side can still respond to cerebral stimuli. A localized compression involving the motor area may lead to convulsions in the corresponding group of muscles. The bladder is paralyzed, and hence retention ensues, whilst the sphincter ani is relaxed, and faeces pass involuntarily, although marked constipation is usually present. The symptoms in some cases are ushered in by severe pain or headache, which is partly due to pressure upon and tearing of the dura mater, and partly to the altered vascular conditions of the brain ; the brain substance itself is not sensitive, and hence the pain is not directly referable to any lesion of or pressure upon it. Naturally the clinical picture is modified according to the cause of the compression, and it is impossible to discuss here more than the general features. The course of the case, too, varies widely according to whether or not the compressing agent can be removed by the surgeon, or absorbed by natural processes. Patients not uncommonly recover from small cerebral and intra- meningeal haemorrhages causing temporary compression, but rarely do so without operation if the symptoms are due to depressed bone, the presence of a foreign body, or large exuda- tions of blood, serum, or pus. The Diagnosis of coma from compression, when a complete history of the case can be obtained, is often easy, and, indeed, the whole clinical aspect may be so typical that no question as to the cause of unconsciousness can be raised. But when a person is found in the streets unconscious, where no history either of the patient or of an accident is obtainable, and where no serious lesion of the skull is present, the diagnosis is often extremely obscure, since coma may be due to many other causes, e.g. : (a) Cerebral lesions, such as apoplexy, whether the result of haemorrhage, embolus, or thrombosis ; or it may be the con- sequence of a preceding epileptic fit, or due to a rapidly spreading oedema in cases of cerebral tumour or abscess, (b) Various toxic agents may induce coma ; they may be introduced into the system from without, as in the case of alcohol, opium, or other narcotics, or may be developed within the body, as in uraemia or diabetic HEAD INJURIES 6S9 coma, (c) Heatstroke or exposure to cold may also lead to unconsciousness. In the latter case there can be but little doubt as to the cause, since the patient is cold, pale, and in a state of severe prostration ; in the former the diagnosis may for a time be doubtful, (d) Lastly, it must not be forgotten that two or more of these conditions may co-exist. Thus, a drunken man may fall and break his skull, and then the smell of liquor in his breath may lead to an erroneous diagnosis. It is therefore evident that a very careful examination of the patient is required before any conclusion can be arrived at as to the cause of the coma, and it is often impossible to make a diagnosis. In such cases the patient should be carefully tended and watched, and not shut up for the night in a police-cell without attendance. The following points should always be observed in the examination: (1) A rapid note should be made as to the sur- roundings of the patient — whether there is blood or vomit near him, how the body is lying, and the nature of the ground. (2) The depth of the coma should be ascertained, and, if possible, the man should be roused, and asked to give an account of him- self. (3) A most thorough and complete investigation should be made as to his condition. His skull must be first examined, to settle if possible whether or not a fracture is present ; the surface temperature of the body is noted, as also the character of the pulse and respirations. The tongue should be looked at, as it is often bitten in an epileptic fit, and the smell of the breath should also be noted. The condition of the pupils may throw some light on the case; in opium-poisoning they are small and equal, a condition also seen in haemorrhage into the pons ; in alcoholism they are often dilated and fixed, but vary considerably in different cases. The amount of power and the state of the reflexes are then observed, any inequality probably indicating a unilateral lesion in the brain. The urine must be drawn off, and carefully examined for albumen and sugar. (4) in dubious cases, and especially where there is any suspicion of drunkenness or poison, the stomach should be emptied and washed out. (5) Finally, if the cause is still uncertain, the patient should be put to bed and carefully watched. The Treatment of compression must be, where possible, directed to removing the cause. When it is due to depressed bone or a foreign body, immediate operation is required ; collections of pus should be opened and blood-clots removed. Failing such measures, the treatment of the condition resolves itself into keeping the patient quiet, with the head low and cool, the room dark and noiseless, the bowels open (using croton-oil on sugar, cr enemata, for this purpose), and the bladder empty. The patient may have to be fed by the rectum, and if the breathing or pulse is very laboured, and cyanosis begins to show itself, venesection may be 44 690 A MANUAL OF SURGERY advisable. Considerable interference with the respiration arises from falling back of the tongue, as often occurs in profound anaes- thesia during surgical operations, and if due to this cause the head may be rolled over to one side, or the tongue pulled forwards. Occasionally patients remain in this condition for weeks or months. Intracranial Inflammation. -Inflammation of the cranial con- tents is often met with as a result of injury, and although we shall describe several distinct varieties, it must be remembered that the various forms run into one another, and that in practice mixed types are the more common, giving rise to a corresponding complexity of symptoms. For descriptive purposes the following groups may be distinguished : (i.) Subcranial Inflammation. — This may occur in the form either of an effusion of pus between the dura mater and the bone (subcranial abscess), or as a thickening of the dura mater (pachymeningitis). The former results from either a compound depressed or a punctured fracture, in which the dura mater is only separated from the bone and not lacerated, especially when the external wound is small and efficient drainage is not obtained. It some- times occurs, however, in consequence of a simple contusion or fracture of the skull, leading to a detachment of the membranes and a collection primarily of blood and later of inflammatory fluids in the cavity thus produced. Microbic invasion is here due to auto-infection, or to the passage of organisms through the bone. Apart from injury, its most common cause is, without doubt, extension of inflammation either from the superjacent bone or from the middle ear. The Symptoms produced are (1) those generally characteristic of suppuration, viz,, a high temperature, with perhaps rigors. (2) The signs of intracranial pressure in the form of fixed headache followed by coma are also present. (3) If there is no open wound, an oedematous swelling of the scalp, known as Potfs puffy tumour, may develop over the site of the abscess (Fig. 249). When there is a compound fracture of the skull, the margins of the wound look unhealthy, and at its base may be seen bare bone, yellow and dry, from which the pericranium has separated, with perhaps pus oozing out between the fragments. If the pus burrows towards the base of the skull, optic neuritis may develop. (4) Focal symptoms of spasm or paralysis may complicate the case if the dura over the motor area is involved. The Treatment of such a condition consists in evacuating the abscess cavity through a sufficient opening made by trephining, or by removing loose portions of bone, and providing for drainage. Sometimes more than one opening is required for this purpose. Simple pachymeningitis, or thickening of the dura mater, may result from a slight simple depressed fracture, or even from con- tusion with or without a fissured fracture. No immediate symp- HEAD INJURIES 691 toms need arise, but those characteristic of chronic meningitis described below are usually met with at a later date ; in fact, it is impossible to distinguish clinically between the two affections. (ii.) Acute Diffuse Meningitis is always infective in nature, and generally due to the pyogenic cocci. Formerly some cases were supposed to result from merely mechanical causes, but they also are probably due to bacteria of lesser virulence, such as the pneumococcus. The symptoms vary considerably in their in- tensity, according to the method of inoculation and the activity of the organisms. The superficial part of the brain is involved in the inflammation as well as the meninges, and the term meningo-encephalitis would perhaps be the better appellation. The Symptoms appear about forty-eight hours after the injury, Inflamed CEdematous bone. scalp tissue. Subdural space. ^.Scalp. s f .Cranium. , Brain covered by pia mater and arachnoid. Fig 249. — Subcranial Suppuration, involving Overlying Bone and causing an CEdematous Condition of the Scalp — Pott's Poffy Swelling (Semi-diagrammatic). (From Treves' ' System of Sur- gery.') although sometimes infection may be delayed beyond this period. In the early stages the patient complains of severe, constant, and increasing headache, associated with heat of head, a forcible pulsation of the carotids, a full pulse, and general irritability of the brain, as indicated by vomiting, intolerance of light and sound, delirium, and perhaps convulsive twitchings of the muscles, not only of the head and back, but also of the extremities. High fever is usually present, and possibly a rigor may occur at the onset. As the disease progresses, the patient gradually becomes comatose, and dies from cerebral compression. According to the site of infection, the inflammatory phenomena may manifest themselves more acutely over one part than another, and for descriptive purposes two chief varieties have been distin- guished, viz., meningitis of the convexity, and meningitis of the base. The general symptoms are alike in both forms, but when 44—2 692 A MANUAL OF SURGERY the convexity is involved, convulsions are a more prominent feature in the case, and may at first be limited to localized groups of muscles, whilst in basal meningitis the temperature tends to run higher, the head and neck are more retracted, optic neuritis is more frequent, and some form of squint is not uncommonly observed. On post-mortem examination the skull-cap is separated from the meninges with some difficulty ; the dura mater is thick and con- gested, and the subjacent veins are manifestly distended ; the cerebro-spinal fluid is increased in amount, and turbid from ad- mixture with lymph or pus ; the arachnoid is thick and opaque ; the surface of the convolutions is flattened and cedematous, and lymph occupies all the sulci, matting them together ; the cortical grey matter is usually red and congested ; the underlying white substance of the centrum ovale is injected, numerous puncta cruenta being evident ; the ventricles are distended with cerebro- spinal fluid, and the choroid plexuses are engorged with blood. The Treatment consists in shaving the head and applying cold by means of an icebag or Leiter's tubes, care being taken that the application is continuous, and not intermittent. In the robust general venesection is useful, but in weaker individuals cupping or leeching may replace it. The bowels are freely opened and a bland diet ordered. The patient should be kept absolutely quiet in a darkened room, and every source of irritation and excitement removed. Even if recovery ensues, it is somewhat delayed, and similar precautions as to quiet, etc., must be main- tained for some time. In the later stages, blistering of the scalp or neck, and the administration of mercury, are advisable. Attempts have been recently made to relieve the symptoms and determine a cure by means of operative measures, directed towards reducing the intracranial tension ; the subarachnoid space has been opened below the tentorium, whilst others have utilized Quincke's plan of puncturing the spinal membranes between the third and fourth lumbar vertebrae, i.e., below the termination of the spinal cord. In no case of acute meningitis has a successful result followed, and when one considers the intricate character of the space to be drained, the fact that it is sure to be subdivided into separate cavities by deposits of lymph, and especially when it is remembered that the important fourth ventricle only communicates with the subarachnoid space through the small foramen of Majendie, which is certain to be early blocked — all these considerations go to prove that it is useless attempting any such measures. Acute Meningoencephalitis is sometimes limited in character, when resulting from penetrating wounds. Such can only occur when there is no tension from retained discharges, diffusion along the meninges being prevented by the formation of adhesions. Localized suppuration is usually present, involving even the brain HEAD INJURIES 693 substance ; but with care recovery is possible, although an adherent cicatrix will be formed, perhaps giving rise to subsequent epileptic symptoms. A similar condition may result from bruising of the bone and a localized suppurative inflammation connected therewith (Fig. 250). (in.) A Subacute form of meningitis is occasionally met with, coming on at a somewhat later date. The patient may have apparently recovered from his injury, with the exception of a fixed pain in the head. The onset of the symptoms is often due to some indiscretion, and may be gradual or sudden. In all probability this affection is also microbic in origin, and the delay in its appearance depends either on the small number of bacteria present, or on their being in a low state of virulence ; or possibly they have been latent for a time, and are aroused into activity by later causes ; or, again, they may have gradually worked their way inwards along lymphatics or vessels from the periphery to Collection of pus beneath Inflamed dura mater. bone. pia mater and arachnoid. Fig 250. — Superficial Abscess of Brain, spreading from Subdural Space (Semi-diagrammatic). (From Treves' 'System of Surgery.') the meninges. The symptoms are similar in character to those of acute meningitis, though somewhat less severe ; but a fatal result is very apt to follow. In the treatment of this form, no active antiphlogistic measures should be adopted, since the patient's condition is somewhat asthenic. Absolute rest and quiet are essential ; counter-irritation should be applied to the scalp and neck, and possibly mercury administered. (iv.) Chronic Meningitis may result from any injury of the meninges, and is very likely to occur in syphilitic patients. It is evidenced by infiltration and thickening of the membranes, which are usually adherent to one another and to the cerebral cortex. It gives rise to a localized headache, which is constant, and increased on excitement or the injudicious use of stimulants, whilst tenderness is often noted on deep pressure, and traumatic epilepsy may ensue. The treatment consists in attention to the 694 A MANUAL OF SURGERY general health, abstinence from excitement or stimulants, the local application of counter-irritants, and possibly the adminis- tration of mercury ; the bowels must be kept regular, and if epilepsy follows, and the lesion can be localized, trephining may be necessary. (v.) Cerebral Abscess. — For pathology, symptoms and treatment of this, see p. 718. (vi.) In conclusion, one other form of intracranial inflammation must be mentioned, viz., Infective Thrombosis of the Sinuses. This, though seen after injuries, is more commonly associated with suppurative diseases of the bone apart from trauma, and one variety, viz., that affecting the lateral sinus, is almost exclu- sively caused by disease of the middle ear. It is also induced by extension from scalp injuries as a complication of subaponeurotic cellulitis, or may spread inwards from erysipelatous lesions of the face or suppurative conditions of the nose. Putting aside the results of chronic otorrhcea, the cavernous sinus is much more frequently involved than any other. Pathologically, the same manifestations are observed as in any case of infective phlebitis. The sinus becomes impervious owing to the presence of a thrombus, and this in turn becomes dis- integrated, and gives rise to multiple emboli, whilst various inflam- matory conditions of the surrounding tissues necessarily result, e.g., necrosis or caries of bones, subcranial abscess, or meningitis. The symptoms are mainly of a pyaemic nature. The tempera- ture is high, but with remissions, and often with repeated rigors ; fixed headache and early and continuous vomiting are also marked features of the case. With these may be associated evidences of meningeal mischief, or of pulmonary trouble in the shape of dyspnoea, but sometimes diarrhoea and septicemic manifestations may be the more prominent. If the cavernous sinus is involved, marked exophthalmos, with congestion of the orbit, and even of the eyelids and face, may result, and ptosis or squint may also be set up by implication of the nerves which lie in the walls of the sinus. If the superior longitudinal sinus is affected, there may be turgescence of the veins of the scalp and forehead together with tenderness along the line of the sinus and epistaxis, whilst convul- sions may be induced by irritation of the neighbouring motor area. For local results and treatment of thrombosis of the lateral sinus, see p. 820. Treatment, except for the lateral sinus, is but rarely possible, and hence the importance of preventing this disease by a most careful attention to asepsis. For the lateral sinus much can be done, but for the other sinuses all that is feasible is attention to general measures. Laceration of the Brain. — Injuries to the brain and its mem- HEAD INJURIES 695 branes are very frequent complications of blows and falls on the head, and all the most serious results of these accidents arise from this source. They are produced in many different ways, and cause very varied symptoms ; but the most important distinction to draw is between those wounds which communicate with the exterior and those which do not. I. Non-penetrating Wounds of the Brain result from blows and falls, which may or may not produce simple fissured or depressed fractures of the skuil, but not unfrequently the most serious cere- bral symptoms follow injuries in which the bones do not participate. In depressed fractures the brain is usually most contused or torn immediately below the injured spot ; but in cases where there is no depression, the greatest mischief is frequently found at a point exactly opposite to that struck, whilst the local bruise may be much slighter. Thus, in the case of one of our students who, in an epileptic fit, fell, striking the left occipital region on a stone pavement, we found postmortem a fissured fracture at the spot struck and a bruise on the left occipital convolution, whilst the anterior portion of the right frontal lobe was severely contused, and, indeed, disintegrated. The explanation of this fact is that the force of the injury is transmitted to the brain substance in a wave which concentrates its violence against the opposite side of the skull. In very sharp sudden localized blows, as from a spent bullet, local bruising of the subjacent brain may be alone produced. Pathological Anatomy. — The immediate effects of such an injury vary considerably. There may be a mere bruise, evidenced by a few points of extravasation, on the surface or in the grey matter ; or the more superficial parts of the brain may be totally disinte- grated and mixed with clots ; or, if laceration has occurred, clots may be found adhering to the injured spot, or extending from it widely into the subarachnoid space, or even, under rare circum- stances, into the lateral ventricle. The later effects in cases where the wound does not communicate with the exterior are mainly those of inflammation or degeneration. Soon after the accident considerable exudation follows, causing the ecchymosed brain substance to swell and become cedematous ; this may speedily subside, but in the more serious cases a spreading oedema may be caused, owing to the pressure of the swollen tissues upon the superficial veins in the pia mater ; the circulation in these is hindered, and increased exudation follows, leading to general cerebral pressure and even death, a consequence hastened by the excess of cerebro-spinal fluid usually induced by the process. Under such circumstances the greater part of the brain is cede- matous and glistening, the injured area being yellowish red in colour, with evident points of extravasation scattered through it. Still later, degeneration of the brain substance may follow owing to the disturbance of its circulation, and is indicated by the presence of a pulpy yellowish mass, soft enough to be washed 696 A MANUAL OF SURGERY away by a stream of water, and containing fat globules and granular cells, with debris of nerve fibres (yellow softening). If the area involved is small and unimportant, the patient may recover perfectly, the softened tissue being absorbed ; if large or implicating important centres, death or paralysis must ensue. In cases of laceration of the brain which recover, a tough depressed cicatrix is formed, usually adherent to the membranes, and con- taining haematoidin crystals, whilst extravasated blood may be organized into a dirty brownish lamina, adherent to the pia mater, or into an arachnoid cyst. Clinical History. — The symptoms necessarily differ with the severity and locality of the lesion. Whenever concussion occurs after ahead injury, and the patient recovers slowly after it, the surgeon will rightly suspect laceration or contusion of the brain. If concussion is rapidly followed by the symptoms of cerebral irritation, there can be no doubt as to the existence of a laceration, which is probably situated in the frontal region. If compression has supervened within twelve or twenty-four hours, it is due to either depressed bone or haemorrhage into the cerebral hemispheres, if there is no interval of consciousness ; but if the patient has rallied for a time before its incidence, haemorrhage from the meningeal vessels or venous sinuses is to be diagnosed, or a rapidly spreading oedema. If localized or general convulsions occur within twenty-four hours of the accident, perhaps going on to compression, haemor- rhage into the cortex of the motor area, or diffuse extravasation into the subarachnoid space, is probably present. It is not easy to distinguish between these two, but haemorrhage into the cortex usually produces a more regular extension of the convulsions, which commence by twitching of some part of the body which the patient at the time is perhaps incapable of moving voluntarily. Thus, if bleeding is occurring into the cortical centres for the face on the left side of the body, paralysis of the right side of the face may be present, and it is here that the convulsions will start, spreading regularly to the right side of the neck, arm, and leg, and then involving the left leg, arm, and side of the head in order, finally becoming general, as in an epileptic fit. After each con- vulsion the paralysis is found to have spread. In haemorrhage outside the convolutions the paralysis is less marked and the con- vulsions less regular, though perhaps more generalized, but the symptoms of compression develop sooner. If coma supervenes rapidly, and is accompanied by hemiplegia, haemorrhage into the corpus striatum, internal capsule, or perhaps into the ventricles, is likely to be present. In simple cases concussion is usually recovered from in a few hours ; the temperature subsequently rises to about ioo° F., and remains so for a few days, whilst the patient complains of fixed HEAD INJURIES 697 pain and headache, which under suitable treatment may entirely disappear. Some impairment of sense or function may, however, persist. If subacute localized inflammation ensues, pain and headache will be complained of with some fever, and insensibility may supervene in four or five days, preceded by convulsions if the motor area is affected. Suppuration in the white substance occasionally results at a later date in this form of injury, giving rise to the symptoms of cerebral abscess. The Treatment of these cases is always an exceedingly anxious matter for the surgeon. In the majority of instances it is merely symptomatic, following the usual course adopted in concussion, compression, cerebral irritation, etc., as indicated elsewhere. The patient is kept absolutely quiet in bed, with an ice-bag to the head, and a purge administered. Depressed bone, if present, will, of course, be dealt with by operation. Early convulsions and paralysis are carefully watched to see if any indication as to the site of the bleeding can be obtained, since it is possible that trephining over the injured spot and removing blood-clots might be advisable ; but the clinical records as to such treatment are very scanty. Late convulsions and paralysis due to inflammation are best treated by shaving the head and applying an ice-cap. If the pulse is full and hard, and the patient otherwise young and healthy, general venesection may be adopted ; the bowels must be moved by a smart purgative, such as croton-oil, whilst bromide in full doses may be administered. If the convulsions continue in spite of such treatment, and become more severe and extensive, the patient will almost certainly die of coma ; trephining over the injured area is then distinctly indicated, the surgeon hoping to find and remove some clot, or, at any rate, to relieve tension within the dura. II. Penetrating Wounds of the Brain result from blows or falls, as in compound depressed fractures ; or from the entrance of foreign bodies, such as bullets ; or from stabs or punctures, which most commonly occur in the weaker parts of the cranium, e.g., the temple or upper wall of the orbit ; or from sabre-cuts or axe-wounds, in which an oblique or almost valvular incision is made through the scalp and cranium, laying bare and wounding the brain and its membranes. In these cases the general disturbance is often slight, compared with the extent of the local injury, so that, although brain sub- stance may protrude from the wound, there is sometimes but little concussion. Any of the conditions due to haemorrhage detailed above may follow, but they may be less severely felt, except in cases where the bleeding is into the substance of the brain, since the blood can escape from the wound. The inflam- matory phenomena following such lesions are mainly septic in A MANUAL OF SURGERY origin, and may be localized or diffuse. In the latter instance general meningoencephalitis manifests itself in the course of two or three days, and is rapidly fatal ; in the former case adhesions prevent the extension of the trouble beyond the neighbourhood of the wound. Hernia cerebri is very likely to follow, and not unfrequently a deep cerebral abscess will complicate matters at a later date. In cases that have been successfully rendered aseptic, the course is similar to that run by a non-penetrating wound, except that, if anything, the immediate prognosis is better, since the opening in the skull and the possible removal of damaged brain substance diminishes the likelihood of compression from simple or spreading oedema. Where the lesion has involved the motor area, permanent monoplegia may persist. The Symptoms arising from a penetrating wound of the brain have been in measure indicated above. In the worst cases im- mediate death may result, or severe concussion, merging quickly into compression, i'rom which the patient never recovers. In the less serious cases there will be a varying degree of concussion, followed after a short interval by the phenomena of inflammation, localized or diffuse, which have already been sufficiently described. Focal symptoms may also arise from destruction of the cortical centres. Treatment. — In all cases of punctured or compound depressed fracture, we have stated that a thorough exploration of the wound should be made, and all depressed or injured bone re- moved. Foreign bodies should be also taken away, if found close to the wound ; but it is doubtful whether a bullet should be sought for, if it has penetrated deeply into the brain, or if it has traversed the brain and fractured the bone on the other side. Probably an aseptic incision, with removal of the splintered frag- ments and a limited search for the bullet, is the best treatment to adopt, and, even if unsuccessful, will do but little harm, if the patient's general state warrants an operation. When he is evidently moribund, it is better practice not to interfere. Pro- truding brain tissue is gently removed, and the whole wound thoroughly purified with carbolic lotion ; even the i in 20 solution may be used without fear. The dura mater should, if possible, be drawn together by one or two sutures, and a small drain-tube or a gauze wick inserted within it. Fragments of bone, if kept warm and aseptic, may be replaced (p. 679), and the scalp- wound closed, except at the drain opening ; the gauze or tube should be removed, if all is going well, in about two days' time. If the temperature rises as a result of septic infection, the wound must be reopened, and every effort made to relieve tension, and thus localize the mischief. Should diffusion occur, as indicated by an increasing severity of the symptoms, the patient must be treated in accordance with the general principles already laid down for dealing with acute meningitis. HEAD INJURIES 699 (In our description of lacerations of the brain we have purposely omitted any mention of the fact that symptoms may arise from inflammatory conditions affecting the bones (p. 711). In actual practice the course of events is often considerably modified by such a complication.) Localized Injuries to the Brain. Thus far we have merely discussed the general symptoms arising from lacerations and wounds of the brain. We must now Fig. 251. — Brain and Convolutions in Situ. The fissures of Rolando and Sylvius are indicated, and the situation of the chief motor centres. P. O. F., Parieto-occipital fissure; / /, level of tentorium with cerebellum below it. The position of the lateral sinus is also seen. rapidly pass in review the special symptoms resulting from injuries of particular regions. Upper and Middle Frontal Convolutions. — Neither motor nor sensory symptoms are noted, but cerebral irritation and subse- quent weak-mindedness are likely to follow, especially if the left side is seriously involved ; lesions to the right frontal lobe do but little harm to a right-handed individual. x\pparently the intel- lectual faculties are limited to one side of the brain, in the same way as the power of speech. 700 A MANUAL OF SURGERY Third Frontal Convolution. — Motor aphasia, i.e., the inability to produce or articulate words, results from lesions on the left side in right-handed individuals, and on the right side in left-handed people. Injury to the opposite convolution has no effect. If only one side is damaged, the other convolution can after a time be educated so as to take on the function of the damaged region. The Motor Area (Fig. 251) is comprised of the ascending frontal and ascending parietal convolutions, respectively in front and behind the fissure of Rolando, of the posterior half of the third frontal convolution, and of the superior parietal lobule. The centres for the leg occupy the upper part of the ascending parietal convolution and the whole of the superior parietal lobule, those for the hip being in front, and for the feet and toes behind. The arm centres are located on either side of the middle of the fissure of Rolando, the shoulder being in front and above, and the hand and fingers below and behind ; whilst the centres for the head, face, and lips are clustered together at the junction of the ascend- ing and third frontal convolutions, the centre for movements of the angle of the mouth being highest, whilst the lowest part of the ascending frontal convolution governs the movements of the tongue and lips. Lesions involving any of these areas produce either spasm or paralysis of the appropriate region on the opposite side of the body. Wounds of one Occipital Lobe may cause a temporary hemiopia, but no persistent loss of vision, unless the angular gyrus is also destroyed. Lesions of the latter region are always associated with permanent disturbances of vision. The Upper Temporo- sphenoidal Lobe contains the cortical auditory centre, and lesions in this region cause deafness ; the function of the middle and lower lobes is not yet ascertained with certainty. Injury to the Corona Radiata leads to paralysis of the regions represented by the overlying cortex, but without convulsions; whilst if the corpus striatum or internal capsule is lacerated, as by haemorrhage, hemiplegia, with perhaps hemianesthesia, will result. Wounds of the Cerebellum cause giddiness, vertigo, and ataxy, the patient reeling about in a most characteristic manner, as if drunk. A wound of the Cms Cerebri occasions more or less complete hemiplegia of the opposite side of the body, associated with total paralysis of the 3rd (oculo-motor) nerve on the side of the injury. Laceration or contusion of the Pons Varolii, if not immediately fatal, may lead to paralysis of the opposite side of the body to the injury, together with paralysis of the 5th, 6th, 7th, or gth nerves, on the same side as the lesion, constituting the so-called ' crossed paralysis.' Marked contraction of the pupils (myosis) may also be present. Wounds of the Medulla are usually fatal. If, however, the patient should escape, he is liable to suffer from disturbed func- HEAD INJURIES 701 tions of the circulatory and respiratory centres, with perhaps Cheyne-Stokes respiration and saccharine diabetes. Cranio-Cerebral Topography. We cannot do more in this work than give a diagram repre- senting the relations of the convolutions to the sutures (Fig. 251), and, in addition, indicate the usual position of the two most important fissures, viz., those of Rolando and Sylvius, and how Fig. 252. — Diagram of Head to indicate Method of finding the Fissures of Rolando and Sylvius by Reid's Method. (After Reid.) Sy. a.fiss., Anterior branch of Sylvian fissure ; P. O. Fiss., Parieto-occipital fissure ; trans, fiss., transverse fissure along line of tentorium ; A, external angular process of frontal bone ; B, occipital protuberance ; C D, anterior perpendicular in front of tragus ; E F, posterior perpendicular through back of mastoid process. to mark out their situation on the cranium, although it must be premised that their position is by no means constant. The Fissure of Rolando may be found topographically by the following methods: (a) The upper extremity of the fissure corresponds to a point half an inch behind the centre of the line extending from the root of the nose to the occipital protuberance. The direction of the sulcus is downwards and forwards at an angle of about 67 to the middle line. This may be indicated by laying a half-sheet of letter-paper over the skull, 702 A MANUAL OF SURGERY the long side corresponding to the middle line, and with its centre over the upper limit of the fissure ; the anterior half is now folded over obliquely from this point, leaving an angle of 45 between the front of the paper and the middle line of the skull ; and then the same process is again repeated, bisecting the angle and leaving one of about 67 , so that the anterior limit of the folded paper corresponds to the line of the fissure, which is about 3§ inches in length, (b) A more exact method is that defined by Dr. Reid, the measurements for which are all worked from the so-called Reid's base-line, which is one drawn on the skull from the lower margin of the orbit backwards through the centre of the external auditory meatus, reaching the middle line behind just below the occipital protuberance (Fig. 252). From it are drawn upwards two perpendiculars, one (C D) corresponding to the small depression in front of the external auditory meatus, the other (E F) to the posterior border of the mastoid process. The fissure of Rolando extends from the upper limit of the posterior vertical line to the point where the anterior line inter- sects the fissure of Sylvius. The Fissure of Sylvius is indicated by a line drawn from a point i|- inches directly behind the external angular process of the frontal bone (Fig. 252, A), and about the same distance above the zygoma, to a spot three-fifths of an inch below the most prominent part of the parietal eminence. The undivided portion of the fissure is represented by the first three-quarters of an inch, and from here the anterior limb (Sy. a. fiss.) rises vertically upwards for about an inch, whilst the posterior limb extends backwards for the rest of the line. If prolonged to the middle line behind, it indicates with tolerable accuracy the situation of the parieto-occipital fissure (P. O. Fiss.). Many complicated craniometers have been devised from time to time, but need no description. For practical purposes the above measurements suffice as a foundation to work out a complete topography of the brain ; and, after all, when it is a matter of operation, the surgeon does not usually limit his field to a single small trephine aperture. Hernia Cerebri. By hernia cerebri is meant a protrusion of the brain substance through an acquired opening in the skull. It thus differs from an encephalocele, which consists in the protrusion of brain substance through some congenital defect. It is always an evidence of increased intracranial pressure, and may be looked upon as Nature's safety-valve for the relief of compression. It is met with in two distinct forms : 1. When an opening has been made by the surgeon for the treatment of a cerebral tumour, w 7 hich is subsequently found to HEAD INJURIES 703 be irremoveable. The disc of bone is not replaced, and the brain substance protrudes through the opening under the scalp ; by this means a temporary relief of intracranial tension is brought about, the patient's life prolonged, and possibly consciousness for a time restored. The tumour, however, continues growing, and sooner or later the patient dies comatose. 2. The other variety, due to a compound depressed or punctured fracture, is the result of sepsis in the underlying brain substance, and the increased pressure within the skull thereby induced leads to a protrusion of inflamed and cedematous brain matter through the wound in the dura, which is usually of small size. The tumour is soft and dusky in colour, and pulsates synchronously with the heart, the pulsations being often evident to the naked eye, and it usually increases in size somewhat rapidly. At first the mental condition of the patient is unimpaired, but sooner or later coma follows, if the hernia progresses, ending in the patient's death. To begin with, the mass consists mainly of cedematous granula- tion tissue covered by blood-clot, without much brain substance, but later on brain tissue itself may protrude. The condition is usually fatal, though recovery is occasionally seen. Treatment. — Prevention of this affection must always be aimed at by en- deavouring to render any wound involving the meninges aseptic and providing for drainage. Punctured wounds and depressed fractures of the skull, even when giving rise to no urgent symp- toms, should always be operated upon, since free relief of tension may prevent the formation of a hernia cerebri, even should absolute asepsis not be attained. If, however, protrusion occurs, it may be possible in a few cases to apply a dry dressing and elastic pressure, and thus prevent it increasing in size ; this, however, must not be attempted when the inflammatory symptoms are at all marked. In such cases it is of little use to slice off the tumour and apply pressure, and possibly the best treatment that has been suggested is to paint the projecting mass with absolute alcohol once or twice a day ; it is an efficient antiseptic, and also tends by its dehydrating power to diminish the size of the hernia. If such treatment is successful, the tumour slowly granulates over and cicatrizes. Traumatic, epilepsy may, however, ensue. Traumatic Epilepsy is the term applied to an epileptic condition resulting from injuries. It may arise from any of the following conditions : (1) A neuralgic and irritable cicatrix in the scalp ; (2) a slight unrelieved depression of the skull ; (3) excessive formation of callus after a fissured fracture, or chronic thickening of the bone from osteitis after a contusion, whereby the dura mater is pressed upon and irritated ; (4) chronic meningitis, usually associated with an adherent cicatrix in the brain, and particu- larly liable to occur in syphilitic patients ; (5) a single depressed spicule of bone projecting into the cerebral substance. A similar 704 A MANUAL OF SURGERY condition is seen apart from injury in consequence of irritative lesions of the dura mater or cerebral cortex, as, for example, from an osteoma on the inner wall of the cranium, or enlarged Pacchionian bodies. The Symptoms produced are epileptic seizures of the Jacksonian type, with or without a definite aura, according to the function of the portion of cerebral cortex which is involved. Localization of the lesion depends partly on the character of the aura, partly on the associated symptoms, such as a fixed headache, or the presence of a cicatrix. The Treat- ment is not particularly satisfactory. If there is any means of determining the site of the irritation, an exploratory operation is always justifiable, since some removeable fragment or spicule of bone may be the cause of the symptoms. If, however, nothing is found except an adherent cicatrix between the membranes and the underlying brain, it is very questionable whether the surgeon should proceed further. In a considerable number of cases the cicatrix and surrounding brain substance have been removed ; the fits have ceased for a time, but in almost every instance recurrence has sooner or later followed, owing to the formation of a fresh cicatrix at the site of operation. Moreover, permanent paralysis of the portion of the trunk governed by the removed cortical area has resulted, and hence the general opinion at the present time is that such an operation is unadvisable, except as a life-saving measure when the fits are extremely numerous and severe. Such a decision emphasizes the importance of the state- ment made before as to the necessity of dealing with all cases of simple depressed fracture in adults by operation. If it is decided that an exploration is desirable, the sooner it is undertaken the better, since the longer the epileptic habit lasts, the less favour- able is the prognosis. As an alternative to excision of the cicatrix, various plastic measures have been suggested in order to prevent the scar in the brain and dura being dragged on by the scalp, or irritated through it, when the bone over it is defective. See autoplasty and hetero- plasty (p. 709). Traumatic Insanity is sometimes produced by slight depressions or lesions, similar in nature to those causing epilepsy, and can occasionally be relieved by operation. Certainly, when a distinct history of injury precedes the mental aberration, and when there is any localizing lesion or symptom, an exploratory operation is justifiable, and in a number of cases excellent results have followed. The type of insanity is not constant, but varies with the condition and environment of the individual. CHAPTER XXIV. DISEASES OF THE SCALP, CRANIUM, AND CRANIAL CONTENTS. Diseases of the Scalp. It would involve a needless amount of repetition to mention and describe in detail all the many conditions which may be met with in the hairy scalp, and therefore it is only necessary to deal with those which are of the greatest importance. Suppuration is of common occurrence, arising mainly from septic infection from without, but being occasionally due to disease of the subjacent bones. The extent of the abscesses is limited by the same anatomical features as obtain in connection with haemor- rhage. Thus, a subcutaneous abscess is necessarily small in size, owing to the density of the tissues in which it is located ; it arises most frequently as a result of eczema or impetigo, and is often due to the presence of pediculi, or to the action of irritants used in the cure of ringworm. A subaponeurotic abscess usually results from a septic penetrating wound, and is associated with cellulitis. A subpericranial abscess is rarely seen except in connection with injury or disease of the bony calvarium ; the pus is limited to the affected portion of bone. Erysipelas and Cellulitis have been described elsewhere (pp. 93 and 96). Tumours occurring in and under the scalp may be considered according to whether they pulsate or not. Pulsating Tumours of the Scalp arise from three distinct sources: 1. They may be of Extracranial origin, and then are mainly asso- ciated with the superficial bloodvessels, (a) Ordinary aneurisms of traumatic origin are not uncommonly seen ; they rarely attain any considerable size, and are readily dealt with by excision, (b) A rterio- venous wounds give rise either to an aneurismal varix or to a varicose aneurism. They usually involve the temporal trunk, and their symptoms and treatment require no special notice, (c) A curious dilated and tortuous condition of one of the scalp arteries, most often the temporal, is occasionally seen, and is known as an arterial 45 7o6 A MANUAL OF SURGERY varix ; it may be treated by complete excision, (d) A neevus situated over the anterior fontanelle may derive a communicated impulse from the subjacent dura. It has no special features apart from this, and is to be treated in the same way as other naevi of the scalp, viz., by excision or electrolysis, (e) A much more serious and interesting phenomenon than any of the others is that known as a cirsoid aneurism. Cirsoid Aneurism is more frequently met with in the scalp than elsewhere, and mainly involves the temporal region, but may also spread in all directions, even downwards into the neck. A tumour of greater or less size is seen under the skin, consisting of dis- tended, tortuous, pulsating, bluish-looking vessels, the arteries opening directly into cavernous spaces without the intervention of capillaries ; it is easily emptied by pressure, but quickly refills, owing to the abundant arterial supply. The rate of growth is variable, and the patient often complains of headache and giddi- ness ; the skin becomes thin and atrophic, the hair falls out, and finally ulceration may occur, the patient probably dying from haemorrhage. The Treatment is eminently unsatisfactory, com- plete excision being the ideal cure, but this in the worst cases is impracticable. If it be attempted, the incisions should be made wide of the disease, and the supplying vessels secured, if possible, between double ligatures before dividing them ; if this precaution is not adopted, frightful haemorrhage may result. It is necessary in some cases to deal with the tumour in separate segments, allowing time between the operations for the patient to recover from the loss of blood. Probably electrolysis, combined with liga- ture of the main nutrient vessels, holds out the best chance of success. (For methods of electrolysis, see p. 309.) 2. The chief pulsating tumours of Cranial origin are as follows : (a) Sarcomata arising from beneath the pericranium or from the diploe (p. 712). (b) Secondary nodules of cancer may develop in the diploic tissue ; those due to the form known as thyroid cancer are specially noted for their pulsation, (c) Aneurism by anasto- mosis occasionally develops in the cancellous tissue of the diploe, and gives rise to pulsation, which can be felt when the bones are sufficiently expanded and atrophied (p. 537). 3. Pulsating swellings of Intracranial origin include the following conditions: Encephalocele (vide infra); traumatic cephal-hydrocele (p. 668) ; hernia cerebri (p. 702) ; and sarcoma of the dura mater (p. 712). Non-pulsating Tumours of the Scalp. — Almost any of the ordinary connective tissue or epithelial growths may occur, but the follow- ing are the more important : Papillomata are not uncommon in the form of small hard warty outgrowths, giving rise to but little inconvenience, unless situated on some spot where the hat rests. They are easily removed. DISEASES OF THE SCALP 707 Epithelioma also occurs, arising either from an irritated papil- loma, or possibly in connection with a sebaceous cyst. As soon as a diagnosis is made, the growth should, if possible, be ex- tirpated, and the resulting raw surface may either be left to granulate, or dealt with by Thiersch's method of skin grafting. Fibroma is either seen in the shape of a localized develop- ment of hard fibrous tissue, and often growing on the forehead where the hat crosses it ; or it may attain much larger dimensions, involving perhaps half the scalp, and giving rise to an irregular nodulated outgrowth of soft fibro-cellular tissue, which has some- times been termed a pachydermatocele (p. 163). Either form may be dealt with by excision. Sarcomata of various types involve the scalp, presenting as large fleshy tumours which may pulsate or fungate. They usually develop rapidly, but are limited for some time by the aponeurosis of the occipito-frontalis ; glandular infection is uncommon. In their removal it is useless to attempt to save the aponeurosis ; the whole thickness of the scalp must be sacrificed, and the in- cisions should be wide of the growth. The wound is allowed to granulate, or covered in with Thiersch grafts. Dermoid Cysts are by no means uncommon in this region, their favourite situation being near the outer canthus, the temple, or the root of the nose. For a general description, see p. 182. They do not attain any great size, and may not become evident till after puberty. The underlying bone is often hollowed out from a defective development of the mesoblastic tissues around them ; and a congenital opening may even exist through which a narrow neck passes, bringing the cyst into direct connection with the dura mater. The treatment consists in removal ; but it is advisable to delay this till after puberty if the tumour seems at all fixed to the skull, or if the bone is felt to be defective beneath it, as in such cases the communication with the interior of the cranium is often shut off by that time. Sebaceous Cysts (p. 361) find their most usual situation in the scalp, where they not only are frequently multiple, but also may reach a considerable size. Their removal is best accomplished by transfixion, squeezing out the contents, and picking out the cyst wall by a pair of forceps without dissection. The wound is closed by one or two stitches. Affections of the Skull. I. Congenital Affections. r. Meniogocele, Encephalocele, and Hydrencephalocele consist of a protrusion of the dura mater, with or without part of the brain, through an opening in the cranial wall, due either to defective development of the bones or to the non-closure of one of the sutures. They occur most frequently at the root of the nose, and 45—2 7o8 A MANUAL OF SURGERY in the occipital region (Fig. 253), occasionally at the anterior or one of the lateral fontanelles, or at the base of the skull. A Meningocele is simply a protrusion of the brain membranes con- taining cerebro-spinal fluid. It forms a soft, rounded, fluctuating swelling, attached to the skull by a base of greater or less size, and covered by skin, which may be thick and healthy, or thinned, bluish, and translucent when the tumour is large. The vessels present in the skin are often dilated and nsevoid. It increases in size and tension on any expiratory effort, such as coughing or crying, and it may be partially reducible, thus allowing the margins of the opening in the cranium to be defined. Symptoms of cerebral compression, convulsions, etc., are likely to be pro- duced by such manipulation. An Encephalocele is a similar type of tumour, but contains brain substance, and pulsates nearly synchronously with the heart ; it is most commonly situated at Fig. 253. -Congenital Encephalocele of the Occipital Region. (Tillmanns.) the back of the skull. A Hydrencephalocele, or Meningo-encephalo- cele, is a condition in which the tumour contains both brain substance and fluid. Two varieties have been described, one in which there is a small protrusion of the brain associated with an ordinary meningocele, and the other in which the fluid is contained in a cavity communicating with one of the ventricles, and covered by a thin layer of brain substance. They are usually of consider- able size, and situated in the occipital region, either above the tentorium, and then possibly associated with distension of the posterior cornu of one of the lateral ventricles, or below that struc- ture, the osseous defect extending in some cases as far as the fora- men magnum, and a portion of the cerebellum being within the sac. The Prognosis of these conditions is exceedingly grave. For- tunately, many of the subjects are born dead, or die soon after birth. In the more severe cases, idiocy and microcephaly are not uncommonly associated. The protrusion may increase steadily in AFFECTIONS OF THE SKULL 709 size and finally burst, causing death by purulent meningitis, or in more favourable cases it may remain stationary. In a menin- gocele, the subsequent growth of the cranial bones may suffice to close the communication between the interior and the tumour, which thus becomes shut off, and remains as a cyst-like swelling, with the base fixed, and without pulsation or respiratory impulse. Treatment. — Most cases should be left alone ; but if the tumour is steadily increasing in size, antiseptic puncture and subsequent compression may hinder the process ; a pure meningocele may possibly be cured in this way. Where the communication with the skull is small, it may be feasible to excise the tumour, taking special care to securely suture the base, and attempting when practicable to make good the cranial deficiency by osteoplasty. 2. In infants the ossification of the bones may be incomplete, constituting what is known as aplasia cranii congenita. It is said to be due to fcetal rickets, arising from a cachectic condition of the mother. Great care is needed in dieting such children and protecting them from injury. Occasionally a similar atrophic condition of the bones may persist through life, exposing the patient to increased risk from injuries which otherwise would do but little harm. 3. Localized congenital atrophy of the bones is also sometimes met with in connection with dermoid cysts, as mentioned above. II. Acquired Affections of the skull are atrophic, hypertrophic, inflammatory, or neoplastic in nature. Acquired Atrophy of the skull occurs in many forms : (a) Craniotabes is a condition met with during the first year of life, usually as a result of inherited syphilis (p. 524). (b) Senile atrophy may affect the whole cranium, which becomes thinned and rarefied, the change commencing from without, a similar condition also occurring in the jaws from the loss of teeth, and subsequent absorption of the alveoli ; or it may be localized, as pointed out by the late Sir G. M. Humphry,- to the parietal bones, constituting hollow depressions which extend antero- posteriorly. No symptoms are caused thereby, but the patient runs a certain increased risk from injuries to the head. (c) Localized loss of substance may result from the pressure of tumours, such as Pacchionian bodies and aneurisms, or from necrosis, or traumatic and operative lesions. If these are at all extensive, the cerebral pulsations can be felt distinctly through the skin. It is then advisable to provide the patient with some guard to protect him from injury. This may be accomplished by means of a metal plate worn over the scalp ; but where the lesion is due to injury or operation, surgeons have of late years been endeavouring to remedy the defect in a more satisfactory manner by operation. Autoplasty is the term applied to a proceeding * Med.-Chir. Trans., 1890, p. 327. 7io A MANUAL OF SURGERY whereby the defect is closed by a plate of bone removed from the patient's own skull. A suitable scalp flap is turned down, and then a portion of the outer table is chiselled up sufficient in size to close the aperture. The pericranium is utilized on one side as a pedicle, and by means of this it is stitched down into the gap, the margins of which have been previously freshened. By hetero- plasty is meant a similar proceeding when the hole is closed by a plate of gold, platinum, or vulcanite let in under the pericranium or inserted between the dura mater and the cranium. The results of these procedures have been on the whole satisfactory. (d) Hydrocephalus is always associated with atrophy and thinning of the cranium. It may be congenital, or may commence early in life, but is always a chronic condition. (The so-called acute hydrocephalus is in reality tuberculous meningitis.) It is produced in almost all cases by a distension of the lateral ventricles with fluid, the result of congenital malformation, or of inflammatory affections, causing exudation from the choroid plexuses, pressure upon the veins of Galen or inferior longitudinal sinus, and possibly closure of the foramen of Majendie. The head becomes more and more distended, the bones expanded and thinned, and the sutural areas increased, whilst the brain is subjected to such pressure as may be incompatible with life. Fluctuation is dis- tinctly felt, and the bones may crackle under the fingers ; the face looks abnormally small, and the eyes protrude, owing to the depression of the orbital plates. Treatment. — The ventricles may be tapped at a spot some little distance from the median line, and a considerable amount of the fluid withdrawn, whilst elastic pressure is subsequently maintained ; but as the cause cannot be removed, recurrence is almost inevitable. It has recently been demonstrated that there is a direct absorption of fluid into the veins from the subdural space at any tension above the venous pressure, and hence it is suggested that, by establish- ing a communication between the ventricular and subdural spaces, the excess of fluid in hydrocephalus might be absorbed. This has been attempted in two or three cases, and the results have been encouraging ; but of course, to be of any value, it must be undertaken before the cerebral cortex has been so thinned as to interfere with its functional activity. (e) By microcephaly is meant a condition of diminished size of the cranial cavity due to premature ossification of the sutures. It is usually associated with idiocy, and possibly with cretinism. Of late years attempts have been made to relieve this by the operation of linear craniectomy or removal of portions of the cranium, so as to allow of the expansion of the brain. A broad strip of bone is excised on either side of the median -line, from back to front, and sometimes another transversely. A small trephine aperture is first made, and then the opening is prolonged antero-posteriorly by a circular saw driven by electricity, or by a AFFECTIONS OF THE SKULL 711 Hey's saw, or by a bone rongeur. The two sides of the skull are usually dealt with at separate times. Temporary improvement has followed in many cases ; but the final result is extremely uncertain, the majority of the patients relapsing owing to the contraction of the dense cicatricial material which replaces the bone. The proceeding cannot be looked on as more than a justifiable experiment. Hypertrophic Changes of the Skull result from simple chronic inflammatory affections, or from injury, etc. We have already alluded to the special types of enlargement seen in inherited syphilis (p. 523), rickets (p. 525), osteitis deformans (p. 530), and acromegaly (p. 531). In leontiasis ossea (p. 742) the cranium also becomes thickened and enlarged ; but the cranial cavity is encroached on, constituting what is known as concentric hyper- trophy, in contrast to most of the other forms, which are eccentric in type. Inflammatory Affections of the Cranial Bones. — The cranium is liable to any of the diseases which generally occur in bone. 1. Acute Periostitis, or Pericranitis, is usually septic in origin, following cellulitis of the scalp ; it is likely to result in necrosis of the outer table. 2. Acute Infective Osteomyelitis, or acute necrosis, consists of an acute inflammation of the diploe, due to pyogenic organisms, and either following a septic scalp wound or a contusion of the bone in a person of low germicidal powers. The symptoms and signs are those generally characteristic of the disease, the peri- cranium being stripped up by diffuse suppuration beneath it, and abscesses opening in many situations. Necrosis of the whole thickness of the skull is likely to follow, whilst pyaomia or extension of the inflammation to the membranes, venous sinuses or brain, are the chief dangers arising from it. The treatment consists in free external drainage ; but in addition it is necessary to remove the outer table with chisel and mallet, and to thoroughly scrape away all the septic diploe, disinfecting the parts beneath with pure carbolic acid. If signs of subcranial suppuration ensue (p. 690), the inner table must also be removed. 3. Chronic Periostitis of the cranium is occasionally met with in the form of a node. It is usually the result of some long- continued irritation, such as carrying baskets or weights on the head. Treatment consists in the removal of the irritation, and there is no objection to chiselling away the node, if necessary. 4. Tuberculous Disease of the cranial bones is not common ; it occurs as a primary phenomenon, or is secondary either to a cutaneous lesion, such as lupus, or perhaps more commonly to a meningeal focus. It may start in the periosteum or diploe leading to the formation of a node or perhaps to expansion of the 712 A MANUAL OF SURGERY bone, and followed by suppuration and caries. When of menin- geal origin, there is a considerable amount of erosion of the inner table, and possibly some necrosis; sooner or later the outer table is perforated and a subpericranial abscess forms. The amount of mischief in the outer table is no criterion of the extent of the disease within, and hence very thorough exploration is necessary. The prognosis in this variety is not good. 5. Syphilitic Disease of the cranium, on the other hand, is exceedingly common, occurring usually in the tertiary stage, and affecting most frequently the frontal and parietal bones. It has been already described (p. 522). Tumours of the Cranial Bones. — The chief Tumours affecting the calvarium are osteomata and sarcomata. Osteoma of the cranium occurs as a localized overgrowth either of cancellous or of compact bone, more commonly the latter. It grows from the outer surface of the calvarium, from the inner, or from both. If arising externally, a smooth, rounded, globular swelling is produced, hard to the touch, quite painless, and attached to the subjacent bone by a broad base ; more than one may be present. If the main growth is internal, the early symptoms will depend on its situation, as to whether evident functional disturbance of the cortex will be produced ; when very large, it gives rise to compression of the brain, and possibly optic neuritis. Osteomata are to be distinguished from inflammatory hyperostoses (usually of syphilitic origin) by their sharp limitations, absence of pain, and slower progress ; whilst osteo-sarcomata are commonly rapid in growth, painful, and of unequal consistency in different parts. Treatment is rarely possible in those developing inside the skull except when situated over the motor area, since the disease has usually progressed too far before coming under observation. The external tumours may be freely chiselled away, but it must not be forgotten that cerebral concussion may follow the pro- longed use of the chisel and mallet against the skull. Sarcoma of the cranium originates either from the pericranium, the diploe, or from the dura mater. The extra- or peri-cranial variety consists of a round or spindle- celled tumour growing from the pericranium, and possibly attain- ing a considerable size. It may contain a certain amount of ossific deposit, or the tumour remains of a soft consistency, and then often pulsates. The subjacent bone is sometimes absorbed, and the dura mater affected secondarily. General infection of the system follows. Central sarcoma of the cranium starts from the diploe as a myeloid tumour. It does not grow so rapidly as the other forms ; it is single, and generally covered with a layer of expanded bone, which gives a sensation of eggshell crackling to the finger. Later on it involves the dura mater and skin, and may fungate. Sarcoma of the dura mater may be attributed to some injury to AFFECTIONS OF THE SKULL 713 the head, and is characterized by the occurrence of severe cerebral symptoms, e.g., intolerable localized headache, epileptic fits, double vision, optic neuritis, etc., prior to any evident appearance of a tumour. Gradually the bones become expanded and perforated, and a soft and exceedingly vascular pulsating growth is felt beneath the scalp. This sooner or later fungates, and possibly the menin- geal cavity is laid open by ulceration, death from septic meningitis, cerebral compression, or exhaustion ending the chapter. Treatment. — These cases have usually gone too far before being recognised. If an early diagnosis can be arrived at, free removal may be undertaken by trephining and the use of the chisel, sharp spoon or gouge. Affections of the Frontal Sinuses. These sinuses are cavities in the frontal bones lined with a mucous membrane continuous with that of the nose. They can hardly be said to exist in children, not developing much before the age of puberty. In adults they vary much in size and shape, and are often very asymmetrical ; the prominence of the super- ciliary ridges is no guide to their extent. Fracture of the anterior wall is not uncommon as the result of a direct blow, depression of the fragments being produced, but with- out cerebral complications. If the mucous membrane is torn, surgical emphysema of the scalp and face may follow, and is naturally increased on blowing the nose. In compound fractures, suppuration usually occurs, leading to septic osteitis and necrosis of the frontal bone, and, if the posterior wall is involved, to a sub- cranial or even a cerebral abscess. In rare cases, when the anterior wall has been destroyed, a localized collection of air may form under the skin, and remain as a permanent tumour, constituting what is known as a pneumatocele capitis ; it rises and falls with forced respirations. A similar condition may also result from a fracture into the mastoid cells ; in either situation it should be treated by compression, or, failing this, incision. Inflammation of the frontal sinus is caused by extension of catarrh from the nose, by penetrating wounds or fractures, by foreign bodies, or it may be secondary to disease of neighbouring bones. But little effect is produced, unless the infundibulum becomes blocked, and then distension of the sinus is produced. If occupied by mucus {hydrops), a slowly-forming tumour is noticed without much pain or discomfort, but the bony walls gradually become thinned, and may give a sensation of eggshell crackling. If dis- tended with pus {empyema), similar symptoms result, perhaps with concurrent inflammatory disturbance and pain in the neighbour- hood. In the more acute cases, especially the traumatic, the in- flammation is liable to extend into the frontal bone, giving rise to an acute osteomyelitis, which may spread rapidly. The pos- terior wall of the sinuses is extremely thin so that the membranes 714 A MANUAL OF SURGERY are easily invaded, and an abscess may develop in the frontal lobe of the brain. Occasionally extension of mischief to the cavernous or other venous sinuses may follow. The case must be treated by laying the cavity open and drain- ing it. F~or this purpose a curved incision is made along or imme- diately below the eyebrow, and the soft parts stripped from the bone, which is trephined or punctured with a gouge, according to its thickness, close to the middle line ; the pus or mucus is removed, the interior very gently curetted, and the passage into the nose explored and dilated so as to aliow of free drainage. The cavity is syringed out for some days, and the wound usually closes readily, although a fistula occasionally remains. A median vertical incision is useful if there is any doubt as to which sinus is involved, or if both are affected. It has also been proposed to deal with this condition from within the nose, and in the hands of skilled rhino- logists this is practicable, especially if the anterior half of the middle turbinal is first removed. Should acute osteomyelitis develop, vigorous measures are necessary. In a case of this type recently under treatment, incisions were made along each eyebrow from the middle line, and a vertical one extending from the hair to the root of the nose. The flaps thus formed were thrown back, the sinuses freely opened, and their anterior walls entirely removed : a large amount of the frontal bone was also taken away until healthy diploe free from purulent infiltration was reached. During the process the posterior wall of the right sinus was removed, and a large cerebral abscess opened. The patient made a good recovery, although a consider- able amount of dead bone had to be subsequently taken away. The chief Tumours growing from the frontal sinuses are mucous cysts or polypi, and ivory osteomata ; they may also be involved in diffuse sarcoma or carcinoma, but the disease is then not limited to the sinus. The main symptoms and signs result from distension of the walls of the cavity, which may yield anteriorly, causing a large frontal swelling, or the posterior wall is absorbed, leading to cerebral compression, or the upper wall of the orbit may be depressed, causing dislocation of the eyeball, and possibly blindness (Fig. 36, p. 167). Tumours which have attained con- siderable dimensions can rarely be removed, death then resulting from cerebral compression ; but occasionally bony masses may necrose, and become loosened by suppuration around them, and in a few cases they have been taken away successfully. Cerebral Tumours. The chief Varieties of new growth met with in the brain are as follows : (i.) Glioma, or glio-sarcoma, which consists of a small round-celled neoplasm with a very delicate intercellular substance, similar in character to the neuroglia ; it may occur in any part of the brain. It is always continuous with the surrounding cerebral CEREBRAL TUMOURS 715 tissue, and is scarcely ever encapsuled, so that to the naked eye it may be indistinguishable from brain substance, although rather harder, and hence its limits can seldom be accurately defined, (ii.) True sarcomata also occur, and occasionally secondary carcino- matous deposits, (iii.) Tuberculous foci are met with apart from any meningeal infiltration, varying in size considerably, and may be either firm and caseous, or with a diffluent centre, (iv.) Gummata of the brain usually spring from the meninges, and are more irregular in shape than tuberculous masses, (v.) Occasionally hydatid cysts are found, as also other less common conditions. Cerebral tumours are more often observed in males than in females, and the different forms occur at varying periods of life. Thus, glioma and sarcoma are most common at puberty or in middle life ; tuberculous foci, in children ; gummata, in the fourth or fifth decade ; carcinomata, in middle or late life ; and parasitic tumours in the second and third decades. The local effects of a cerebral tumour may be to cause some amount of sclerosis of the surrounding brain substance, whilst, if superficial, the membranes may become adherent and the over- lying bone thickened. The Symptoms of a cerebral tumour can be classified as follows ; (1) Those due to increased intracranial pressure, such as fixed headache, giddiness, epilepsy, loss of memory, and stupor, finally ending in coma. The headache varies much in character, but is usually localized, occurs in severe paroxysmal attacks, and is often associated with tenderness on deep pressure over the scalp. It is increased by anything that causes passive congestion of the brain, such as coughing, and it is most important to note that the sites of the maximum pain and of the tumour often correspond. Occasionally coma and a fatal issue supervene suddenly as a result of acute spreading oedema (p. 695). (2) Vomiting and constipation are also very marked phenomena, associated with loss of appetite and great emaciation. The vomiting bears no relation to the ingestion of food, and is not preceded by nausea. It often develops concurrently with the pain, or may relieve it, and is most common in subtentorial tumours. The temperature is usually subnormal, but if there is any basal meningitis it may be elevated. (3) Optic neuritis is generally present, and is supposed to be due either to the increased intracranial pressure causing obstruction to the return of blood from the eye to the cavernous sinus, or to a descending neuritis, or possibly to both. In the early stages, the clear definition of the disc margin becomes obscured, and the retinal veins congested and tortuous ; the retina is ©edematous, so that the vessels are only seen at intervals, and linear ecchymoses may also occur. If the patient lives long enough, atrophy of the disc follows. In the early stages vision may be but little affected, but, as a rule, it is considerably im- paired towards the end. In some cases this condition may 716 A MANUAL OF SURGERY be more marked on the side of the lesion, but is generally bi- lateral. (4) Focal symptoms (p. 699) are only produced when some area of the brain with definite functions is involved. Irritative phenomena manifest themselves first ; paralytic symp- toms develop later on. General convulsions sometimes occur, but are without much significance. We must refer students to text-books of medicine for a further consideration of these lesions. The surgeon is seldom called upon to make a diagnosis in these cases, and therefore the full details of this intricate subject will not be considered here. Treatment. — In every case, the possibility of the symptoms being due to gummatous disease must not be forgotten, and large and increasing doses of iodide of potassium (even up to 40 or 60 grains three or four times a day) should be administered before undertaking operative proceedings. Symptoms of gastric irrita- tion must be prevented by giving some alkaline carbonate (especially the ammonium or soda salts), whilst the dose should be freely diluted with water. Operation. — It is most desirable that this should be undertaken as early as possible, since, even if no tumour exists, the patient runs but little serious risk, whilst delay until all the classical symptoms are well marked may prevent the total removal of the growth- Occasionally it is divided into two stages, one consisting in the removal of the bone, and the other, six or eight days later, involving the intracranial portion ; but such a modification is not essential, and is sometimes undesirable. The scalp should be entirely shaved a day or two previously, and very thoroughly purified. A quarter of a grain of morphia is injected about half an hour before the operation, with the idea both of reducing the vascularity of the brain and of dulling the patient's sensations, so that a smaller amount of anaesthetic is subsequently needed. Chloroform should be employed rather than ether, as it produces less congestion of the head. The surgeon marks the spot selected for the application of the trephine by drilling the bone with a bradawl through the scalp. A large semicircular flap is then turned down, exposing a considerable area of the calvarium, so that if a larger amount of bone than is expected needs to be removed, no fresh scalp incisions are required ; moreover, the cicatrix will in this way be prevented from forming over the trephine opening. A crucial incision is made through the pericranium, which is retracted to a sufficient extent to allow a 2-inch trephine to be applied, the centre-pin being placed in the hole previously made by the bradawl. A Gait's trephine (i.e., an instrument with shelving borders) is to be preferred to one of the ordinary type. The disc of bone is care- fully removed, and placed in warm and sterilized normal saline solution, so that it may be subsequently replaced if necessary. Other methods of removing the calvarium have been introduced, CEREBRAL TUMOURS 717 so as to enable a considerable area of the brain to be exposed. Thus, the bone may be partially sawn through in such a way as to divide the portion to be removed into rectangular areas ; then if the whole thickness of the bone is removed at one spot by a trephine, it is easy to cut away the remainder with bone pliers. Other surgeons prefer Wagner's osteoplastic method, which con- sists in turning down a flap of skull with the soft parts. After the superficial incision has been made, the bone is divided along the same line, either by a circular saw driven by electricity, or by one of the ingenious surgical engines — more or less resembling a dental drill — which have been recently introduced, or by a Gigli saw (i.e., a piano wire with a screw thread turned on it). In using the last-mentioned contrivance, two or three trephine open- ings must be made along the line of incision, and the wire carried through on a probe from one to the other. Handles are attached at each end, and the sawing is soon accomplished ; it is advisable to bevel the cut so as to give a shelf for the flap to rest on when replaced. The base of the flap is partially or wholly sawn through, and then the upper portion prised outwards. It is for such severe measures as these that the operation in two stages is recommended. The dura mater when exposed under normal conditions is firm, but yields slightly to the finger, and allows the pulsation of the subjacent brain to be felt, if the latter is healthy and no undue pressure is present within ; but if the intracranial tension is markedly increased, the dura mater bulges into the wound, feels firm and unresisting, and the cerebral pulsations are diminished or absent. The dura mater is next incised crucially, or a flap turned down, care being taken to avoid, if possible, the meningeal vessels ; the brain substance protrudes if the intracranial pressure is excessive. The region is gently explored by the finger, and any areas of abnormal hardness or softening noticed ; failing this, a grooved needle is inserted in different directions, or a fine trocar and cannula. In introducing such instruments, care must be taken to make direct stabs, and never any lateral movements, which necessarily lead to laceration of the brain. The opening of the skull may be enlarged, if need be, either by the use of the bone rongeur or by additional small trephine holes. It is but rarely that a cerebral tumour is so placed that enucleation is possible. If, however, a cortical neoplasm is found, it is isolated from the surrounding brain substance by blunt instruments, e.g., the handle of a scalpel, or a flexible knife, made of platinum, as suggested by Horsley, and the mass freely removed. Haemorrhage is controlled by the application of a fine ligature, or by the use of serrefines, or by sponge pressure. The dura mater is then loosely stitched together, and a drainage-tube inserted, reaching to the bottom of the wound, and brought out at one angle of the incision in the skin, which may be closed by a continuous suture. If the tumour has 7 i8 A MANUAL OF SURGERY been satisfactorily enucleated, the disc of bone may be placed in situ, room, however, being left for the passage of the tube ; but if there is any doubt as to its complete removal, the opening in the bone is left. After the operation, the patient must be kept absolutely quiet, with the head slightly raised. The drainage-tube may be removed in twenty-four or forty-eight hours, and the scalp wound is usually healed in six or seven days. Even if the tumour is inaccessible or irremovable, temporary benefit often results from an exploratory operation, since a sub- cutaneous hernia cerebri is thereby allowed to form, and intra- cranial tension relieved, as evidenced by an improved mental condition and loss of pain ; as the tumour grows, however, the patient relapses into his former state, and death sooner or later follows. Abscess of the Brain. Causes. — Pyogenic infection is, of course, the ultimate cause of all cerebral suppuration, but the manner in which the organisms find their way to the brain varies considerably, (i.) It maybe due to traumatism, either in the early or late stages of head injuries. In the early, it is usually superficial, and connected with some in- fective lesion of the scalp, cranium, or membranes, with or with- out a penetrating wound (Fig. 250). In the later stages the pus forms deeply in the white substance. It may be due to a pene- trating wound, whether a foreign body is present or not, the microbes finding their way into the interior of the brain either through the track of the missile, or along bloodvessels or lym- phatics. Sometimes it occurs apart from penetration, and then one can only suppose that it is due to auto-infection of a contused or lacerated area. Chronic abscess of this type is most frequently seen on the same side of the brain as the lesion, and the parietal and frontal lobes are most often affected ; occasionally, however, it may occur on the opposite side in the same way as a contusion, (ii.) It arises by extension of an infective lesion from without, the organisms reaching the brain by direct continuity of tissue or by way of the bloodvessels or lymphatics. The commonest cause of all abscesses in the brain is chronic otorrhcea, and it appears that the cerebellum is more frequently involved than the cerebrum. In the former the abscess is usually in the anterior portion of the lateral lobe, close to the back of the petrous bone, whilst in the latter the posterior portion of the temporo-sphenoidal lobe is most frequently affected. The inflam- mation may spread directly from the tympanic cavity or inner aspect of the mastoid process through the bone to the membranes, which become adherent to the brain, and then into the cerebral substance ; occasionally a direct opening has been found through the tegmen tympani into an abscess cavity, and it has even dis- charged itself and been drained in this way. More commonly a ABSCESS OF THE BRAIN 719 layer of brain tissue intervenes between the membranes and the pus, and then infection will have been carried along vessels and lymphatic sheaths running from the middle ear to the brain. Abscesses of a similar type occur in connection with suppura- tion in the frontal sinus, the abscess being usually acute and secondary to a frontal osteomyelitis, and occupying the anterior portion of the frontal lobe ; it may also follow purulent infection of the sphenoidal and ethmoidal sinuses, or thrombosis of the cavernous sinus. (iii.) The infective material may be brought to the brain by the blood in pyaemia, or after some of the exanthemata, such as scarla- tina, typhoid, etc. (iv.) A chronic abscess of tuberculous origin may also occur. A cerebral abscess is usually single ; occasionally more than one is present, e.g., a cerebral and cerebellar may co-exist in con- nection with middle-ear mischief. The course taken by the case is generally chronic, and then the pus is encapsuled ; in acute cases there is usually no limiting membrane. A chronic case not uncommonly terminates in an outbreak of acute symptoms, due either to the abscess bursting into one of the lateral ventricles, or to the supervention of spreading cedema. The Symptoms vary somewhat with the method of onset and the characters of the abscess. If traumatic and due to infection from without, the case runs an acute course, associated with intense pain in the head, recurrent rigors, and rapid development of coma. Diffuse meningitis is often present, and the two con- ditions can scarcely be distinguished. In not a few of the cases of chronic abscess, all that the patient complains of is headache, until suddenly the temperature rises with a bound, he becomes unconscious and dies within a day or two. Such a course of events is probably due to the bursting of the abscess into the lateral ventricle or meningeal cavity, and to the onset of an acute spreading cedema. When the symptoms are more characteristic, they may be grouped together under the following three heads : (1) Those resulting from the presence of pus within the body. These are, however, not typical, since, although there may be an initial rigor, the temperature is usually normal or subnormal, unless basal meningitis co-exists. (2) Those due to intracranial pressure and irritation. Pain in the head is usually the earliest and most marked of these ; at first it is often general, but later on becomes fixed, and localized to the seat of the abscess. It varies greatly in amount, sometimes being of the most agonizing type, sometimes very slight ; it is usually continuous, but may be intermittent, and entirely disappear for a time. Anorexia, malaise, vomiting, and constipation are often present ; the pulse is usually slow and inter- mittent, and Cheyne-Stokes respiration may occur in the later stages. Epileptic seizures may also be induced, and the patient 720 A MANUAL OF SURGERY passes into a state of mental torpor, and even coma. If unrelieved, the patient dies in a state of coma, from interference with the vital centres in the medulla. Optic neuritis, more marked on the affected side, is another symptom, and the pupil on that side is dilated and does not react to light. (3) Focal phenomena arise as in cases of cerebral tumour, varying necessarily with the situation. In most cases of temporo-sphenoidal abscesses they are not marked ; but if the anterior part is involved, irritative or paralytic symptoms may be noted on the opposite side of the face, or aphasia if the lesion affects the left hemisphere, whilst if situated in the posterior part symptoms may arise from pressure on the cerebellum through the tentorium, almost exactly simulating those due to an abscess or tumour in the cerebellum. The signs connected with an abscess in the cerebellum are often very indefinite and vague, but if symptoms develop at all they are very characteristic. The patient complains of giddiness, and staggers when attempting to walk, falling towards the opposite side ; the arm on the same side may be paralyzed ; nystagmus and lateral deviation of the eyes towards the opposite side are also present. The condition is more common in adults than in children. Diagnosis. — From meningitis, a cerebral abscess is usually recognised by the fact that in the former condition irritative phenomena, such as acute and active delirium, contraction of the pupil, photophobia, rigidity and spasm of muscles, especially in the back of the neck, and severe pain, are more evident and are produced earlier. The temperature is usually high, and mental dulness comes on within three or four days of an injury, whereas an abscess rarely forms before the end of the first week. Extra- dural abscess (subcranial) is associated with a high temperature, earlier onset after an injury in traumatic cases, and more rapid compression symptoms ; optic neuritis is only occasionally met with, and the vomiting is less troublesome. There is also likely to be some localized cedema or tenderness on deep pressure. The diagnosis from thrombosis of the lateral sinus is, as a rule, not difficult, owing to the fact that in abscess symptoms of compres- sion are associated with a low temperature and marked optic neuritis ; whereas in thrombosis the temperature is high and oscillating, optic neuritis may be absent, and there may be the characteristic tenderness in the neck. It must not be forgotten that the two conditions may co-exist. It is often impossible to diagnose between a chronic abscess and a tumour of the brain ; the symptoms in the latter may, however, come on more slowly than in the former, but the progress is steady and unrelenting ; the temperature remains near the normal, and there is less gastric disturbance. The history of the case may throw some light upon its nature, since in cases of cerebral abscess there is usually some causative septic focus, but an exploratory operation is often necessary to clear it up. Tumour is more common in the frontal ABSCESS OF THE BRAIN 721 and parietal regions, abscess in the temporo-sphenoidal lobe. Optic neuritis is more marked and more common in tumour than in abscess. Treatment necessarily follows the usual rule, viz., to give an exit to the pus as soon as possible ; no delay is permissible when once symptoms have made themselves evident. The patient is prepared in the same way as for operation on a cerebral tumour. A flap of scalp tissue is raised, and in such a manner as will most effectually serve for subsequent drainage purposes. The trephine is applied according to the rules given below, or in accordance with the special indications given by the symptoms of the case. Professor Macewen recommends that, when the circle of bone has been removed, the exposed surface and cut edge should be well rubbed over with powdered iodoform and boracic acid so as to guard them from infection. The dura mater is then carefully incised in a crucial fashion, and this may suffice to open the abscess ; but more usually the brain substance protrudes. It is carefully explored with a trocar and cannula, which is passed directly into it in various directions. In a temporo-sphenoidal abscess the most likely direction to explore is downwards and inwards towards the tegmen tympani. Pus having been dis- covered, a pair of sinus forceps is gently inserted along the track of the cannula and opened, so as to enlarge the passage and give exit to it. A twin drainage-tube (i.e., two tubes sewn together at one end) is then inserted so as to reach the abscess cavity, which is gently irrigated with sterilized salt solution until it comes back clear. The dural flaps are of course left open, and it may be wise to pack gauze around the tubes in order to shut off the meningeal cavity by the formation of adhesions. The tubes must not be dispensed with too early, as pus will re-accumulate, and the wound need re opening. Possibly it is well to remove one of the tubes in twenty-four hours after the operation, and to replace the second by one of smaller calibre in two or three days ; in this matter the surgeon must be guided by the character and amount of the discharge. Of course it is undesirable to keep it in too long for fear of the development of a hernia cerebri. For an abscess in the temporo-sphenoidal lobe, the centre pin of the trephine may be placed ii inches above Reid's base line, and about the same distance behind the centre of the external auditory meatus (Barker), but a better situation is a spot f inch above the posterior root of the zygoma, and directly above the posterior border of the osseous meatus (Macewen ; Fig. 295, D). For an abscess in the cerebellum the point selected is 1^ inches behind the centre of the external auditory meatus, and 1 inch below the base line (Fig. 295, E). In the latter case the soft parts, including the muscles and periosteum, should be stripped off the occipital bone, and turned downwards, and it is often unnecessary to apply 46 722 A MANUAL OF SURGERY a trephine, as the bone is very thin, and may be broken through with a gouge. When the diagnosis is doubtful, the mastoid antrum is first opened and explored ; by carefully removing the bone behind and above this opening, the lateral sinus is next exposed ; and, finally, by working above or below it, the cerebrum or cerebellum can be examined, and, if need be, incised. A similar result can be obtained by applying a f-inch trephine to a spot i inch behind the meatus and h inch above the base line (H. P. Dean). The lateral sinus lies in the lower portion of the opening, and the dura over the temporo-sphenoidal lobe in the upper ; by enlarging the opening downwards by Hoffman's rongeur, the cerebellum can also be explored. CHAPTER XXV. AFFECTIONS OF THE LIPS AND JAWS. Affections of the Lips. Hare-lip. — By hare-lip is meant a congenital fissure of the upper lip, which may extend for a variable distance through the soft tissues alone, or may also implicate the bony alveolus and the ^im^jsmkt^'. Fig. 254.— Single Incomplete Hare- Fig. 255.— Double Hake-lip: com- lip, involving merely the tissues plete on the left slde, incom- of the llp, and not extending plete on the rlght. into the Nose. .■?28+r- P A B Fig. 256. — Double Complete Hare-lip, with Displacement Forwards of the Central Portion of the Intermaxilla (Os Incisivum). A, Front view ; B, seen in profile. floor of the nose, and extend backwards through the palate. The name is not a good one, since a hare's lip is cleft in a Y-shaped 46 — 2 724 A MANUAL OF SURGERY manner, the fissure being central below, and bifurcating above into each nostril. Varieties. — A hare- lip is complete or incomplete, according to whether or not it extends into the nostril. It is termed simple if limited to the soft parts ; alveolar, if the bony alveolus is also involved; complicated, if associated with a cleft palate. The defect may exist on one or both sides of the middle line ; if unilateral or single, it is most common on the left side, in the proportion of two to one ; if double or bilateral, it is usually, but not invariably, alveolar, and accompanied by a complete cleft of the palate. The Fig. 257. — Head of Fcetus, of about Five Weeks, from Ventral Aspect (after His), showing the Primi- tive Stomod^um bounded above by the Undivided Fronto-nasal Process, laterally by the Max- illary, and below by the still separate Mandibular Processes. (Sutton.) The quinque-radiate appearance is well represented. Fig. 258. — Head of Fcetus of a Little Later Date (Six to Seven Weeks), from the Ventral Aspect. (Sutton.) The mandibular processes have now united ; the ocular vesicle is seen on either side towards the upper end of the orbito- nasal fissure, and the fronto- nasal process has developed internal and external nasal processes on either side of the still unclosed anterior nares. central portions of the lip and alveolus (os incisivum) may either retain their normal position, or, as is more frequently the case, project forwards at the end of the nose, forming a proboscis- like appendage (Fig. 256, A and B). Even in simple cases the nose is deformed, being broad and flattened, a condition which becomes much more marked when the alveolus and floor of the nose are widely fissured. Hare-lip is not uncommonly associated with other deformities — e.g., spina bifida and talipes — and it is frequently transmitted from one generation to another. Occa- sionally a thin red line, as of a cicatrix, is seen occupying the position of a hare-lip cleft, and is probably due to a persistence AFFECTIONS OF THE LIPS AND JAWS 725 of the raphe of union of the labial segments ; a slight groove in the alveolus may also be observed at a corresponding point. Development. — (For fuller details of the development of bare-lip and cleft palate, we must refer readers to 'Harelip and Cleft Palate,' by W. Rose; Lewis and Co., 1891. Space only permits a very brief summary here.) The bony and fleshy parts of the face originate from the outgrowth of processes around the cavity formed by the bending forward of the primitive cerebral vesicle over the end of the notochord. At about five weeks after conception the primitive buccal cavity or stomodaeum has a quinque-radiate appearance, due to the manner in which these processes are formed (Fig. 257). A broad median lappet (fronto-nasal process) descends from above ; this is separated by a fissure on each side from the symmetrically-placed maxillary processes, and these again below from the more prominent mandibular processes, which early unite across the middle line, to form the lower jaw. The fronto-nasal process soon, however, changes, developing four rounded buds, the relations of which are indicated in Fig. 258. On either side of a slight depression in the median line is placed the internal nasal process, from which are produced Fig. 259. — Diagram to represent the Albrecht Theory of Hare-lip, showing the situation of the cleft in the alveolus between the Inner and Outer Segments of the Intermaxilla. EG, Endognathion ; MG, mesognathion ; XG, exognathion ; i x , central incisor; » a , lateral incisor; c, canine; m lt m„, first and second molars. superficially the central portion of the upper lip, and from its deeper aspect the inner segment of the intermaxilla (endogathion, Fig. 259, EG), carrying the central incisor. Separated from this by a hollow, which subsequently forms the anterior nares, is the rounded external nasal process, from which develop the side of the cheek, the ala nasi, and from its deep side the outer segment of the intermaxilla (mesognathion, MG) and probably the lateral incisor. External to this a fissure runs up to, and even beyond, the primitive eye (naso-orbital fissure), and this is later on closed by amalgamation of the internal and external nasal processes on the inner side with the adjacent maxillary process on the outer, except in the deepest part, which constitutes the nasal duct. The integrity of the upper lip is obtained by the union of the lower parts of the internal nasal and maxillary processes, which thus exclude the external nasal from participation in its free border. It is doubtless owing to this arrangement that the sulcus or depression around the ala nasi constitutes such a distinct and characteristic feature of the face. At the same time the deeper parts of these nasal processes are uniting with one another and with the palatal plates, which grow horizontally inwards from the under side of the maxillary processes, uniting in a Y-shaped suture, the point of junction of the limbs being situated at the anterior palatine canal. The union 726 A MANUAL OF SURGERY of all these elements is taking place from the sixth to the tenth week, and by that date even the uvula, the last part to unite, should be complete. Ordinary hare-lip is due to a failure of union of the internal nasal process with the structures in external relation with it; if limited to the soft parts (simple hare-lip), the cleft runs between the internal nasal and maxillary- processes ; if complete or alveolar, between the same two below and super- ficially, but in addition between the internal and external nasal processes above and on the deep side. The cleft in the alveolus passes between the inner and outer segments of the intermaxilla (Fig. 259), and is thus bounded on the inner side by the central incisor, on the outer side by the lateral incisor. Occasionally two teeth are found growing from the endognathion, the outer of the two being an accessory tooth, whilst the lateral incisor, and presumably the outer segment of the intermaxilla, are often undeveloped, or exist in a very rudimentary condition attached to the maxilla. The os incisivum, or projecting portion of the intermaxilla, consists of two segments of bone, the two endognathia, united in the median line, and in a child contains two milk central incisors, and the rudiments of the two permanent ones; occasionally, as we have just stated, there may be an accessory tooth developed on one or both sides of the process. A simple hare-lip does not interfere seriously with the infant's nutrition, but when double, and especially if associated with a cleft palate, considerable trouble may arise, thus necessitating surgical treatment as a life-saving measure at a very early date. It must also be remembered that all movements of the face — e.g., in crying or laughing — exaggerate the deformity from the unbalanced action of the divided orbicularis oris and other muscles. As to the period at Avhich to operate, it is better to allow the infant to get over the shock of its entrance into the world and become acclimatized to an independent existence, whilst at the same time the operation should be performed before the troubles of dentition begin. From six weeks to three months is perhaps the best age for operation — in well-nourished and healthy children at the earlier date, in poorly-fed and weakly children at the later, unless the inanition is due to the difficulty of giving nutrition owing to the deformity. Under such circumstances the operation may have to be undertaken within the first three weeks. Operation for Single Hare-lip. — The child should be laid on an operating-table with its arms bound to the body. The surgeon stands behind it, the anaesthetist and assistant one on each side. The operation may be described in three stages : 1. The lip is thoroughly dissected up from the maxilla and alveoli by cutting through the reflections of mucous membrane and the attachment of the muscles and other soft parts. This is mainly needed on the outer side, and where there is much flattening of the nose the ala nasi will also require to be separated. This may cause some amount of bleeding, but sponge pressure easily controls it. 2. The edges of the cleft are then pared. Many different methods have been employed to accomplish this, but it is only necessary to mention two. The object to be attained is the union of the AFFECTIONS OF THE LIPS AND JAWS 727 cleft lip by means of a cicatrix, which shall be as unobtrusive as possible, whilst the red margin must be continuous, and the section such that the raw surfaces are larger than are absolutely necessary, so as to allow for subsequent cicatricial contraction Fig. 260. — Rose's Operation for Single Hare-lip. On the left side the semilunar incisions are seen extending as far as the free borders of the lip. The right-hand figure shows the parts drawn into position ; the wide cross lines represent the wire sutures, the narrow ones the catgut or horsehair stitches. without the development of a notch. The methods recommended are as follows : (a) The incision extends from the apex of the cleft, or from within the nostril, in a crescentic manner (Fig. 260), so that a slight angular projection is formed to constitute a prolabium. Fig. 261. — Mirault's Operation for Hare-lip. In the right-hand figure the prolabial flap is shown ready to be implanted on the prepared inner side. This is done on each side, and where the nose is much flattened, more tissue is removed on the outer than on the inner side, so that when the parts are sutured together the nostrils become as nearly as possible symmetrical. By this means the depth of the lip is increased to allow of subsequent contraction, whilst the red margin can be made continuous. 728 A MANUAL OF SURGERY (b) Miraulfs Operation (Fig. 261). — -The inner margin and apex of the cleft are pared, so as to leave a raw surface ; a flap of red marginal tissue, as thick as possible, is then cut from the outer side, and implanted on the bevelled raw surface of the red margin on the inner side, the upper portions of the cleft being also apposed. 3. Sutures are now inserted to maintain the lip in the position into which it can be drawn by the fingers without tension. Two deep silver- wire sutures should be introduced, one just above the red margin, and one close to the nose, to draw into position and steady the nostril, which should be left smaller than that on the other side, so as to allow for subsequent dilatation, which is certain to occur. Horsehair or catgut stitches are used to bring the exact margins together, the continuity of the muco-cutaneous line being accurately preserved, and the cut edges of the mucous membrane upon the deeper aspect being sutured, each stitch, after it is tight- ened, being used to elevate and evert the lip and thus assist the insertion of the next. The wound is dressed with a small piece of gauze, and secured by another dry piece cut in the shape of a butterfly, so that the narrow body shall fit over the lip, and the wings spread over the cheeks ; this is fixed by collodion, and maintained for some days after the stitches are removed, the deep ones on the fourth day, and the superficial ones about the eighth or tenth. Careful feeding by the spoon is necessary, the mother's milk being drawn off and given in this way, if possible. In simple cases the child may be returned to the breast about the fifth day. In order to prevent the child from picking at the lip or disturbing the dressing, it is well to put a splint on the flexor side of each arm to control the elbow-joint. The Treatment of Double Hare-lip may be discussed under two headings, viz., the treatment of the os incisivum, and that of the soft parts. The os incisivum need not be touched if it retains its normal position, and the labial clefts are then alone dealt with ; but if it projects forwards, as is often the case, it must be either removed or replaced, (a) In the former case the central portion of the upper lip is freed from it by dissection, and the base of the process divided with cutting pliers ; a small artery in the bone will spurt vigorously, and may need an application of the cautery to stop it. The operation on the lip is deferred till ten days later, (b) Re- position may be effected by several methods, the best of which is Bardeleben's, who incises the lower border of the septum, strips off the muco-periosteum from either side, and then bends or breaks the bone back into position, fixing it by silver wires, and uniting the lip at once to form a splint to maintain it in situ. The advantages claimed for reposition are that the patient retains his own central incisor teeth, and that the normal contour of the jaw and face is not interfered with. Against this plan, however, must be placed the facts that the bone rarely becomes firmly united, that the teeth are stunted and erupt obliquely backwards AFFECTIONS OF THE LIPS AND JAWS 729 from rotation of the process, and that its presence prevents the maxillae from falling together and increases the difficulties of subsequently closing the palatal cleft. Personally we recommend Fig. 262. — Rose's Operation for Double Hare-lip. The central tubercle is pared in a V-shaped manner, and the lateral segments by curved incisions, extending to the red margin, and then inwards. Only the apex of the central portion is included in the completed lip. The long cross lines represent the position of the wire stitches, the shorter ones of the catgut sutures. extirpation in bad cases, since the disfigurement can to a large measure be removed by adding a projecting cheek-plate to that which carries the artificial incisors, thus pushing the upper lip forwards, (c) Where, however, the projection is not great, it is possible to diminish the size of the os incisivum by gouging away the teeth contained within it, so that the lip can be closed over it. The soft parts of the lip are dealt with in much the same way as in single hare-lip. They ^ are freely detached from the \ maxillse, and the edges pared, ^fc as shown in Fig. 262, the central ^ portion being cut into a V, and no attempt made to incorporate it into the free margin for fear of Fig depressing the tip of the nose, whilst the lateral segments are pared as in the single operation. These latter are now drawn together and united in the middle line below the central portion, so that a Y-shaped cicatrix results. One of the deep silver stitches should fix the apex of the V ; the other should be inserted just above the red margin. The dressing and after-treatment are as in the single operation. For a time the child may have difficulty in breathing owing to the diminution in the size of the oral aperture, but this is obviated by the nurse drawing 263. — Median Hare-lip. (Pitts' Case.) 730 A MANUAL OF SURGERY down the lower lip with the fingers, or by painting it in a vertical direction with collodion. Other congenital abnormalities of the lip are met with, which, however, can only be briefly mentioned here. Median Hare-lip may occur in one of two forms : either a simple cleft exists in the middle line (Fig. 263), or there may be an absence of the intermaxilla and nasal septum, causing flattening of the bridge of the nose, and a broad median defect, flanked by the maxillary portions of the lip. Oblique Facial Cleft is an uncommon deformity, characterized by a cleft or sulcus in the face, starting from the usual situation of a hare-lip below, but running up outside the nostril to the inner side of the lower lid (Fig. 264). Coloboma of the iris or choroid is sometimes associated with this rare defect. The deformity is due to non-closure of the naso-orbital fissure, and runs along WITH (Fer- Fig. 264 — Oblique Facial Cleft, or, rather, Cicatricial Deformity along the llne usually traversed f ig - 2 ^5 • macrostoma by such a Cleft. (Kraske's Case.) Auricular Appendages. GUSS(5N.) the line of the nasal duct. It may be limited to the soft parts, or may involve the bones, even laying open the antrum. Macrostoma (Fig. 265) is characterized by an abnormal width of the mouth, and is due to non-union of the maxillary and mandibular processes. It may be uni- or bi-lateral, and is usually associated with anomalies of development of the ear, accessory auricles being often present. As a rule, a small papilla on the upper and lower margins will indicate the true limits of the mouth, being constituted by the points of attachment of the orbicularis. The existence of these is of great importance as indicating the extent to which the cleft must be pared in order to restore the mouth to its normal size. Mandibular Clefts are exceedingly rare. They are due to non-union of the mandibular processes in the middle line, and involve either the soft tissues of the lower lip alone, or may extend to the bone, and even the tongue. Treat- ment is as for ordinary hare-lip. Microstoma is the term applied to a condition in which the fusion of the parts entering into the formation of the lips progresses to a greater extent than usual, so that the oral orifice is contracted. It may be associated with defective development of the lower jaw. In the more severe cases, where the mouth is extremely narrowed, a transverse cut should be made outwards on each side, and the mucous membrane stitched to the skin. AFFECTIONS OF THE LIPS AND JAWS 731 Macrocheilia, or hypertrophy of the lip, occurs in three forms : 1. The congenital variety, a condition analogous to macroglossia, and due to a congenital distension of the lymphatic spaces, or chronic lymphangiectasis, accompanied by overgrowth of the connective tissue. The lower lip is most often involved, and is firm, thickened, and everted, causing considerable deformity. The treatment consists in the removal of a V-shaped portion from the centre. 2. An acquired form occurs in children and young people with a tuberculous inheritance, constituting the so-called ' strumous lip.' Either lip may be affected, but perhaps more frequently the upper ; the thickening is probably of a chronic cedematous nature, maintained by the persistent irritation of cracks and fissures. If these can be healed, and the general health improved, diminution in the size of the lip soon follows. 3. In adults, macrocheilia is in almost all cases due to tertiary syphilis. The lower lip is most often enlarged, and becomes thick and hard. It is due to the diffuse sclerosis characteristic of tertiary mischief. General treatment, and not local, is needed. Syphilitic Affections of the lip are not uncommon. A primary chancre may be caused by kissing, or by smoking an infected pipe, or drinking from a glass with an infected rim. It usually presents a smooth ulcerated surface, dis- charging a small amount of sero- pus, resting on a mass of infil- trated tissue which may extend over the whole lip (Fig. 266). The induration is not so great as in chancres upon the genital organs, but the infiltration is much more extensive. An indo- lent enlargement of one or more of the submaxillary lymphatic glands occurs very early, and the disease usually runs an acute course. Ordinary specific treat- ment is all that is needed. A labial chancre may closely re- semble epithelioma, but is dis- tinguished from it by its rapid development up to a certain point, by the early implication of the glands, which soon be- come very large, by the absence of typical cachexia, by the age of the patient, and the course taken by the case, as well as by the local appearances. The surface is usually flattened, and less warty and irregular than in Fig. 266. — Chancre of Upper Lip. (From a Photograph.) The enlargement of the submaxil- lary lymphatic glands is very evident. 732 A MANUAL OF SURGERY epithelioma, whilst the skin is more involved than the mucous membrane. Should the chancre have existed for any time, the presence of a rash or sore throat may materially assist in forming a diagnosis. Moreover, it is said to be more common on the upper lip, whilst epithelioma is usually seen on the lower (com- pare Figs. 266, 267). In the secondary stage mucous tubercles are frequently met with, involving the inner side of the lip and the angle of the mouth. In the tertiary period serpiginous ulceration and gummata may occur, or the diffuse induration described above. In inherited syphilis, cracks and mucous tubercles are con- stantly present, and may be so extensive as to leave cicatrices radiating from the mouth, which are very characteristic (Fig. 17). Cracked Lips (or, as they are often called, chapped lips) are usually the result of cold weather, a central crack or fissure forming which is extremely painful, and liable to bleed very readily on everting or stretching the part. The lower lip is that generally affected. In tuberculous children more than one may occur, and by their persistence they give rise to a considerable degree of induration and infiltration, and perhaps lead to glandular trouble. All that is needed in the shape of treatment is the appli- cation of a little lanoline or cold cream, but if they persist, it may be advisable to touch them with nitrate of silver. Herpes Labialis is a condition usually associated with catarrh, and not unfrequently with pneumonia or other fevers. Either lip may be affected, and the herpetic eruption is quite limited in extent. It consists of a number of little vesicles situated on a hyperaemic and painful base ; after a few days the vesicles become transformed into pustules, and these in turn burst and dry up, the whole affection lasting perhaps a week or ten days. No special treatment is required. If the inner aspect of the lip is affected, the epithelium early becomes sodden and is shed, so that the vesicular stage is much shorter. Mucous Cysts occur on the inner side of the lip in the form of small rounded swellings, which are translucent and contain a glairy fluid. They are often due to trauma, whereby the opening of a mucous gland is blocked. The whole cyst wall should be dissected out, and the wound closed by stitches. Nsevi are frequently met with in the lip. If confined to the inner aspect they may be dissected out, but when large and involving the whole thickness, they should be dealt with by electrolysis. Warty Growths are often seen on the lower lip, especially near the angle, and may then simulate epithelioma. They are dis- tinguished, however, by the fact that ulceration is not often pre- AFFECTIONS OF THE LIPS AND JAWS 733 sent, that the lymphatic glands are not involved, and that there is but little infiltration of the base. They should, however, be removed as early as possible, since malignant disease often starts from them. Epithelioma of the lip usually occurs in men of the working classes, and is commonly stated to be due to the irritation pro- duced by smoking a short clay pipe, which is allowed to rest on one or the other side near the angle. A semicircular notch will frequently be noticed in the teeth of the upper and lower jaw, corresponding to the situation of the growth on the lip, and caused by the constant fric- tion of the pipe-stem. It may also start opposite the site of some projecting rough or carious tooth. It is but rarely met with in women, occurring in England in not more than 5 to 6 per cent, of the cases, and of these, according to Hutchin- son, half are clay-pipe smokers, whilst in Warren's female cases, amongst the Irish in Glasgow, three-quarters were smokers. It is also more common amongst country folk who use the short clay pipe than amongst the cigarette and cigar smokers in towns. The disease may start as an induration around a crack or fissure, which gradually extends, forming a typical malignant ulcer ; or as a wart-like growth, which fungates and ulcerates ; or as a chronic infiltration leading to an irregular nodular thickening of the lip (Fig. 267). If allowed to run its course unchecked by treatment, the disease steadily progresses, forming an ulcerated mass of greater or less size, and even involving the jaw. The submental and sub- maxillary glands are early implicated, and secondary deposits are also found in the glandulae concatenatae. Beyond this, however, Fig. 267. — Chronic Epithelioma of Lower Lip. (From a photograph.) 734 A MANUAL OF SURGERY the disease rarely extends, visceral complications being uncommon. When a fatal issue results, it is generally caused by the secondary growths in the neck, which attain considerable dimensions and then ulcerate, this stage being possibly preceded by one of cystic degeneration. From these ulcerating surfaces a variable amount of discharge escapes, varying with the septicity or not of the wounds. Haemorrhage is also likely to follow from erosion of some of the vessels in the neck. The Diagnosis of epithelioma is rarely doubtful, but occasionally warty growths, or even a primary chancre (p. 731), may be mis- taken for it. The clinical history generally suffices to determine the nature of the mass, as also the character of the base and the appearance of the parts ; but in uncertain cases the removal of a small portion under cocaine, and its microscopic examination, are required to set doubts at rest. Treatment. — The primary growth can almost always be excised completely without much difficulty ; if glands are also enlarged, these should be removed where such is feasible, but when once the con- catenate group has been attacked, they often con- tract such adhesions as to render their extirpa- tion impracticable. If the growth is limited to one part of the lip, a V-shaped wedge extend- ing half an inch beyond it in all directions may be taken away (Fig. 268), and the wound closed, as in a case of hare-lip, with- out much deformity re- sulting. When it is more extensive considerable ingenuity must be exercised in order to make good the defect. One plan that often gives good results is to excise the growth by a some- what larger V-shaped incision, and then to extend the labial fissure transversely to one or the other side, or to both, dissecting up these segments from the bone ; the flaps can then usually be brought together, whilst the mucous membrane is united to the skin along the margin of the new lip. When the whole lower lip requires removal, Symes' opevation may be performed with advantage. It consists first of all in the complete excision of the diseased lip. Two curved incisions are then made, starting from the middle line of the wound, and ex- tending downwards under the chin, to terminate below the angles of the jaw, an inverted V-shaped portion of skin between them Fig. 268. — V-shaped Incision for Removal of Epithelioma of Lip. AFFECTIONS OF THE LIPS AND JAWS 735 remaining fixed to the symphysis menti to form a base of support for the new lip. The lateral flaps are now dissected up, raised, and united one to the other in the middle line, so as to constitute the new lip, an inverted Y-shaped cicatrix resulting. The elasticity of the skin in this region allows this to be accomplished, and the whole wound closed, without leaving any part to granulate. The mucous membrane should be finally stitched to the skin over the upper free margin. Healing by first intention usually follows. If the whole of the upper lip needs to be removed, it may be restored in a variety of ways. Perhaps one of the best consists in making incisions which skirt the alae nasi on each side, and then extend outwards into the cheeks sufficiently to allow the tissues, when they have been freed from the maxillae by under- cutting, to be drawn together in the middle line. In such cases care must be taken not to encroach on Stenson's duct. Affections of the Gums and Alveolar Processes. Spongy Gums are not unfrequently met with as a result of the administration of mercury, or from scurvy. They are characterized by being soft and congested, bleeding readily on pressure, and perhaps showing signs of ulceration. All that is necessary is the correction of the determining cause and the use of an alum mouth- wash. Alveolar Abscess (Fig. 269) is almost always associated with suppuration around the fang of a carious tooth. The alveolar walls become expanded, and the pus finds its way over the edge of the bone (C, D), or even through the osseous tissue (A), under the external periosteum. If limited in extent, it perforates the gum directly, and is then known as a gum-boil ; but it occasionally burrows beneath the periosteum, which is stripped from the bone, and may thus lead to an abscess of larger size, possibly resulting in necrosis of the jaw. The formation of an alveolar abscess is almost always associated with a considerable amount of pain of a very irritating nature, and when extensive may give rise to serious con- stitutional disturbance. Occasionally graver complications ensue ; thus, in the upper jaw the antrum may be opened, and suppura- tion in this cavity follow, whilst in the lower the abscess may travel downwards and burst externally, either close to the lower margin of the bone or in the neck. A troublesome sinus results, which can only be cured by the removal of the tooth, and even then a depressed and adherent cicatrix ensues, which is very unsightly. The most essential point in the treatment neces- sarily consists in the removal of the offending tooth. Often this is quite sufficient, and possibly the tooth may come away with an abscess cavity attached to one of the fangs. When suppuration occurs beneath the periosteum, the pain can at first be relieved in measure by fomentations, but as soon as fluctua- 736 A MANUAL OF SURGERY tion is detected an incision should be made through the mucous membrane, and the cavity emptied. Possibly it may be wise to keep a small piece of stuffing in for a few hours, but if a large enough opening has been made, all that is subsequently required is repeated and frequent irrigation, preferably with peroxide of hydrogen. If a small sinus persists after removal of the tooth, it must be opened up, and any carious or necrosed bone removed. Pyorrhoea Alveolaris (or Riggs's Disease) consists in an inflam- matory condition of the margins of the gums, accompanied by a muco-purulent discharge, which arises from pockets or pouches which may extend a greater or less distance along the roots of the teeth. In consequence of this the tissues of the gums shrink, and, together with the alveolar border, become atrophic ; the Fig. 269. — Diagram of Alveolar Abscess, resulting from Disease of Molar Tooth. (After the American System of Dentistry.) A, Abscess arising from escape of septic material from the pulp chamber, B, through the foramen at apex of the fang ; it has burrowed directly through the alveolar process and burst through the gum ; C, similar abscess, which has tracked down between the tooth and the alveolus, and spread out beneath the alveolar periosteum at D, constituting the t)'pical alveolar abscess ; E, cheek ; F, antrum ; G, nasal cavity. fangs are thereby uncovered, and the teeth loosened, so that after a while the patient is likely to become edentulous. The process is limited to a few teeth, or may involve many. It is always pre- ceded by an excessive deposit of tartar, beneath which bacterial infection occurs, the inflammation spreading down along the peri- odontal membrane. Treatment consists in the removal of the tartar and the application of astringents and antiseptics, prefer- ably peroxide of hydrogen, not only to the exposed mucous membrane, but also into the pouches and pockets where pus collects. Treatment is often prolonged and tedious, but must be AFFECTIONS OF THE LIPS AND JAWS 737 persisted in, not only to save the teeth, if possible, but also to prevent or remedy the toxaemic and dyspeptic symptoms which are due to the absorption of the pus. In many cases, however, the teeth have to be sacrificed. Hypertrophy of the Gums is met with in the form of a sessile over- growth, sometimes almost cauliflower-like, around and between the teeth ; it occurs most frequently in children, but occasionally in older subjects. It is sometimes associated with carious teeth, and should be cut away with a scalpel. Dental Cysts are by no means uncommon, resulting from the irritative effects of dental caries ; hence they follow the distribution of that affection, and are most frequently seen in connection with the upper first molars and bicuspids. They develop at the roots of the teeth, causing a painless regular expansion of the bone, free from inflammatory phenomena, unless infected secondarily with bacteria. After a time the centre of the swelling softens, and, as the bony wall is absorbed, parchment-like crackling can be felt ; finally, the condition presents as a rounded tense elastic swelling, around the margins of which the remains of the ex- panded bone can be detected. The tooth which is the cause of the trouble is always dead, and frequently merely a septic root is present. The cause of these cysts is probably the proliferation of certain embryonic remains of the enamel organ, brought about by the irritation of septic matter which has escaped from the pulp cavity. These fcetal residues are lighted up into activity, develop into masses or cylinders of epithelial tissue, and then undergo cystic degeneration. Their pathogenesis is practically identical with that of the epithelial odontome, but merely one cyst develops here instead of many. The fluid contained therein is thick and mucoid in character, and broken-down epithelial cells and choles- terine are seen in it on microscopical examination. Treatment. — The cyst must be laid freely open into the mouth, the septic tooth or stump removed, and the anterior wall of its alveolus cut away. The alveolus and cyst thus laid into one cavity are scraped so as to remove all the epithelial lining, and packed with gauze so as to ensure healing by granulation. Epulis. — By this term is meant a tumour growing from the alveolar periosteum. Two varieties are described, viz., the simple and the malignant. A Simple Epulis is usually of a fibromatous nature, and may grow from either jaw, though more commonly from the lower. It is generally due to the irritation of diseased teeth, and although most marked on the outer aspect, it burrows between the teeth, and is also found on the inner side. It appears as a red fleshy mass, smooth, or perhaps lobulated (Fig. 270), of an elastic consistency, and possibly associated with a little superficial ulceration. It is 47 738 A MANUAL OF SURGERY covered with mucous membrane, and may contain a few spicules of bone. The treatment consists in removing the growth together with the teeth or stumps with which it is connected. If small, it will suffice to cut away and scrape the bone from which it arises ; but if large, or if it recurs after such treatment, the portion of the alveolus from which it springs must also be excised. This is best accomplished by extracting a tooth on either side of the tumour, and cutting vertically through each socket with a saw, the two incisions being united below with a chisel, so as to remove a quadrangular portion of bone without interfering with the con- tinuity of the jaw. Malignant Epulis. — This title is applied to a myeloid sarcoma growing from the medullary substance of the alveolar process. It forms a soft rapidly increasing mass of a dusky purple colour, which runs on to ulceration or fungation. The deeper portions of the growth may contain an ossific deposit. As with all forms of myeloid growth, it is only locally malignant. Treatment consists in free removal of the mass and of the portion of alveolus from which it arises. In the upper jaw this usually neces- sitates excision of the complete palatal seg- ment of the maxilla, but in the lower jaw it is generally possible to maintain the con- tinuity of the mandible by removing merely a quadrilateral portion in the same way as for a simple epulis. Epithelioma and Sarcoma (round or spindle-celled), arising from the gum, are both occasionally met with. Epithelioma in this situation rarely fungates, but rather tends to invade the bony tissues, and in the upper jaw extends upwards to the antrum ; hence, it is sometimes termed a ' creeping or burrowing epithe- lioma.' The ordinary signs of this disease become evident, lymphatic glands are enlarged, and typical ulceration of the gum follows. The only possible treatment consists in free excision of the growth, together with the portion of bone affected. Fig. 270. — Simple Epulis. AFFECTIONS OF THE LIPS AND JAWS 739 Necrosis of the Jaw. — Causes : (1) Subperiosteal alveolar abscess, connected with dental caries. (2) Traumatism, such as blows . on the jaw, with or without fracture, in the latter instance being due to septic periostitis or osteomyelitis, owing to the lesion becoming compound. It is also not uncommonly caused by the use of dirty forceps or elevators in extracting a tooth. (3) In tertiary syphilis necrosis also occurs, affecting most frequently the palate or alveolar borders. (4) It occasionally results from mer- curial poisoning, bu< such is rarely seen at the present day. (5) Phos- phorus necrosis is met with amongst those who work in lucifer- match factories, but only when ordinary phosphorus is used ; the amorphous form is harmless. The fumes are supposed to gain access to the jaws through carious teeth, giving rise to a somewhat acute inflammation, which terminates in necrosis. A considerable amount of new bone forms beneath the periosteum, and the seques- trum, which is curiously grey and porous, like dirty pumice-stone, is always slow in separating. Either jaw may be affected, but per- haps the lower a little more commonly than the upper. (6) Necrosis may follow one of the exanthemata, arising as an infective idio- pathic or embolic osteomyelitis, and then probably affecting a considerable extent of bony tissue, possibly the whole mandible. (7) Tubercle is occasionally responsible for this condition. The symphysis menti in children is occasionally the seat of a pyogenic or tuberculous infection, previous to the eruption of the permanent incisors. An abscess forms, and caries, or a limited necrosis results. In a case of this type an opening is required in the submental region, through which the diseased tissue can be thoroughly scraped away. The teeth are of course lost, but a good result, and with but little scarring, may be anticipated. The Clinical Phenomena associated with necrosis of the jaw are necessarily much the same whatever the cause. In the acute form, inflammatory symptoms are well marked, the face becoming swollen, red and shiny, and severe pain is experienced. Sooner or later an abscess forms, which may point either in the mouth or on the face, or the pus may burrow downwards for some distance into the neck. Sinuses persist, discharging the most offensive pus ; a new case of bone sometimes forms in the lower jaw, enclos- ing the sequestrum, but in the upper this is rarely noticed, and even in the lower it is not unusual to see a considerable amount of bare or dead bone absorbed without the formation of an involucrum. Treatment. — In the early stage the mouth should be fomented, and as soon as there is any suspicion of pus a free incision is made down to and along the bone. When necrosis is present, it must be treated in the ordinary way. the sinuses being flushed out with an antiseptic solution three or four times a day until the sequestrum is loose ; it is then removed, if possible, from within the mouth. Drainage by means of an external opening is often absolutely necessary. 47—2 74 o A MANUAL OF SURGERY Affections of the Antrum. Suppuration within the Antrum frequently arises from disease connected with the fangs of the first or second molar or bicuspid teeth ; it not uncommonly extends from the nasal cavities in con- nection with disease of the middle turbinated bone, or may be secondary to suppuration within the frontal sinus ; it is occasion- ally lighted up by injury. In chronic cases it is not unusual to find the antrum filled with soft polypi. The Symptoms produced are often extremely equivocal, and the condition may be present for some time without being recognised. In the chronic forms there is usually a little local tenderness over the antrum, and perhaps some swelling of the mucous membrane or of the cheek, whilst there is an intermittent discharge of pus into and from the nose. This varies considerably in amount and character, being sometimes extremely offensive. It is stated by Heath that, although the patient notices the fcetor himself, it is not, as a rule, discerned by other people, thus differing from ozaena. On holding the patient's head forwards, it can be demon- strated that there is an overflow of pus into the nostril, and some- times when the patient reclines it flows back into the pharynx. Should the opening into the nose become blocked, all the symp- toms are aggravated, the pain becoming more marked and the swelling increasing. Signs of distension of the cavity may also be produced in this way ; such are manifested in four directions : (a) Inwards, causing obstruction to nasal respiration, and possibly epiphora, from compression of the nasal duct ; (b) upwards, lead- ing to protrusion of the eyeball or exophthalmos ; (c) downwards, resulting in depression of the side of the palate, and possibly irregularity in the line of the teeth ; and (d) outwards, giving rise to a somewhat characteristic projection of the cheek beneath the malar eminence. Under these circumstances, a finger inserted into the mouth, between the cheek and the bone, will detect a loss of resistance in the anterior wall of the antrum, and if the disten- sion has lasted long, eggshell crackling may be noticed, or the whole anterior wall may be absorbed and an elastic swelling take its place. Infraorbital neuralgia is often a marked feature in these cases. In acute cases all the above phenomena may be present in an accentuated degree, accompanied by severe tensive pain and some amount of febrile disturbance. Necrosis of the lining bony walls may also be induced, owing to the fact that the mucous mem- brane is closely adherent to the periosteum. The Diagnosis of suppuration within the antrum is by no means readily made, since there are many conditions which simulate it somewhat closely. Perhaps the most important sign is the periodic discharge of pus from the nose, and if this can be induced AFFECTIONS OF THE LIPS AND JAWS 741 by change of position of the head, it is pathognomonic of disten- sion with pus of one of the accessory sinuses connected with the nose, probably of the antrum. The association of such a pheno- menon with a dead or painful first molar or bicuspid is also a most suggestive occurrence. Another method which has been recommended is that known as transillumination of the antrum. A small electric lamp is placed within the mouth, and if the patient is in a dark room, and his antra are normal, the cheeks, lips, and lower margins of the orbits become of a rosy-red colour. If, however, the cavities are occupied by pus, blood, or a growth, the parts remain dark. Transillumination does not answer in every individual, and hence the value of the test is much diminished. The presence of illumination excludes intra-antral growths or abscess, but its absence, unless unilateral, is not of much significance. The Treatment of this affection consists in freely opening and curetting the antrum from the mouth, so that the cavity may be washed out and drained. Various methods have been adopted to mttain this end, and perhaps the most satisfactory consists in making an incision through the anterior wall above the first molar after dividing the mucous membrane. This tooth, the fangs of which encroach upon the cavity, should also be drawn, and the anterior wall of its socket cut or gouged away. In bad cases a good opening must also be established into the nasal cavity so as to allow a thorough flushing of the antrum two or three times a day. To prevent the opening from closing too quickly, a tube made of gold, silver, or platinum, and fitted to a small tooth- plate, should be inserted. It is taken out and cleansed night and morning, and plugged during meals. In those cases secondary to intranasal disease, the first essential is to deal with the origin of the mischief in the nose by scraping away all granulation tissue and diseased bone. The antrum is often opened in this way from the nose, and in the majority of cases this will suffice to enable the cavity to be irrigated and drained. In old-standing cases where chronic suppuration persists, the cavity should be freely opened up from the mouth, examined by the finger, scraped, flushed, and stuffed with gauze. Hydrops Antri is the term applied to a chronic distension of the antrum with a glairy mucoid fluid, somewhat similar in character to that contained in a ranula. The condition is pain- less, and free from inflammatory phenomena, and as the ex- pansion increases, eggshell crackling of the anterior wall, or even distinct fluctuation, may be observed. It was formerly supposed to arise from obstruction to the aperture into the nose and re- tention of secretion, but it is in reality due to a cystic tumour forming from the mucous membrane and the glandular elements contained therein, or to a dental cyst (p. 737) which has en- croached on the antral cavity. The treatment required is to thoroughly open the antrum from the mouth after dividing the 742 A MANUAL OF SURGERY mucous membrane, subsequently removing a sufficient portion of the anterior wall to enable it to be washed out and drained. Various Tumours may originate in the antrum, e.g., mucous polypi, fibromata, odontomata, osteomata, sarcomata, and cancers. If limited to the cavity, they produce no definite symptoms, except when large enough to cause expansion of its walls. Malignant growths, however, usually pass beyond the limits of the antrum, and lead to the usual signs of malignant disease of the upper jaw. Treatment consists in removing simple growths, if possible, without interfering with the integrity of the maxilla. This may be accomplished by reflecting the overlying cheek, as in incision of the upper jaw. For malignant tumours, removal of the whole bone is the only possible remedy. Tumours of the Upper Jaw. Many of the Simple Tumours springing from the upper jaw have been already described amongst those involving the alveolar border and antrum. Only a few remain to be dealt with. Osteoma occurs either in the form of a tumour composed of compact tissue, then usually growing within the antrum, or it is occasionally met with as a diffuse symmetrical overgrowth, con- stituting the condition known as Icontiasis ossea. . A few cases of Chondroma have also been repeated. By Leontiasis Ossea is meant a disease, fortunately very rare, characterized by the formation of diffuse hyperostoses from either the cranial or facial bones, or from both. It usually commences in young adult life, and both rickets and syphilis have been suggested as playing some part in its causation, although really nothing definite as to its origin is known. Nodular outgrowths of soft spongy bone are gradually developed, increasing slowly in size, and giving rise to irregular bony protuberances projecting beneath the skin, and when affecting the maxillae and mandibles leading to an extremely repulsive appearance of the individual. Sometimes merely the cranial bones are affected, at other times only the jaws, whilst occasionally the whole skull participates in the change, which is almost always symmetrical. As growth pro- gresses, the new bone tends to encroach on the cavities contained within the skull, so that the antrum may be obliterated, the eyes may protrude owing to the contraction of the intra-orbital space, and even coma and death may supervene from cerebral compres- sion. Prior to this, however, a variety of symptoms, especially neuralgia, may be induced by pressure on the cranial nerves. Treatment is only occasionally possible, and consists in the removal of the projecting masses of bone by the chisel. A few fairly satis- factory results of such a procedure have been recorded. AFFECTIONS OF THE LIPS AND JAWS 743 Malignant Disease of the Upper Jaw occurs in the form of sarcoma or cancer. Sarcoma is perhaps the more common, and originates either from the anterior wall, from the cavity of the antrum, or from the spheno-maxillary fossa behind the bone. Sarcomatous naso- pharyngeal polypi also spread from the nose, and involve the maxilla secondarily. Not unfrequently these growths have a con- siderable ossific deposit within them, and this is occasionally so extensive as to obliterate the antral cavity, and convert the bone into a solid mass. Cancer develops in the form of squamous epithelioma, springing from the gums ; or as a columnar or acinous cancer starting in the glandular tissue, found both in the nasal and antral cavities. The Clinical Features of all forms of malignant disease are practically identical. If arising from the anterior aspect of the bone, a tumour is pro- duced which projects under the cheek, the tissues of which are invaded by it ; it tends to travel down towards the mouth, and is readily detected through the mucous membrane. It may, how- ever, spread deeply, and in time involve the cavity of the antrum. It causes no obstruction to nasal respiration, and no epiphora except in the later stages. If it originates within the antrum, the usual signs of distension of that cavity are produced, associated with a foul, and often blood-stained, discharge from the nose, within which the ulcerated surface of the growth may be seen. Epiphora is caused by pressure on the nasal duct, whilst the growth has been known to burrow upwards along this passage and project near the inner canthus. The passage of air through the nose on that side is also impeded. If the growth commences behind the maxilla, it usually springs from one of the walls of the spheno-maxillary fossa, or from the base of the skull, and is then characterized by a great tendency to spread or burrow in all directions. Thus, it may perhaps push the whole bone bodily forwards without encroaching upon the antrum ; sometimes it finds its way outwards to the pterygoid fossa through the pterygo-maxillary fissure, or inwards to the nose through the spheno-palatine foramen, or even up into the orbit ; whilst more rarely it spreads downwards along the posterior palatine canal, so as to appear at the postero-external corner of the palate ; in the later stages it is not uncommon to find the antral cavity also involved, and even the base of the skull is not exempt from the ravages of the disease. The General Signs of a malignant growth of the superior maxilla consist in the appearance of a tumour which, according to its origin, produces various effects, but finally tends to destroy the bones and occupy the whole of the maxillary region. It is usually accompanied by nasal obstruction, epiphora, and 744 A MANUAL OF SURGERY frequently by a discharge of blood or pus from the nares. Severe pain sometimes accompanies the process, especially affecting the second division of the trigeminal. Neighbouring lymphatic glands become enlarged, more especially in the carcinomata ; those in the submaxillary region are first involved, and afterwards those in the anterior triangle ; secondary deposits in the viscera may also occur somewhat later. The tumour follows a typical malignant course, and, owing to the great vascularity of the parts, its onward progress is very rapid. The Diagnosis of malignant disease of the jaw from a simple tumour should be readily made ; the later age at which it appears, the rapidity of its growth, the greater pain and more abundant discharge from the nose, the associated enlargement of the lymphatic glands, and the tendency to spread and to encroach upon surrounding structures, all point to malignant disease. In some cases, however, an exploratory incision must be made into the antrum, in order to make certain of the diagnosis. More frequently the existence of a tumour at all is for some time entirely overlooked, some one prominent symptom, such as neuralgia or epiphora, being treated without ascertaining the cause. Treatment consists in free removal of the growth, if such be practicable, together with total or partial ablation of the superior maxilla. Where, however, the tissues of the cheek have been invaded, or where the growth has spread beyond the limits of the antrum, the surgeon may well hesitate before recommending an operation, since complete eradication is always a matter of un- certainty and difficulty, and often secured only at the expense of terrible mutilation and considerable risk to the patient's life. Of course, in those cases which spring from behind the maxilla, operative treatment should never be lightly undertaken. Excision of the Superior Maxilla. The operation is performed for the purpose of removing new growths, simple or malignant, either originating in the upper jaw, or extending into it, whilst it is also sometimes employed as a preliminary in dealing with tumours of the base of the skull. Naturally the exact steps vary considerably in different cases according to the character and extent of the disease. Operation. — The patient's head and shoulders are well raised, and anaesthesia is maintained by means of chloroform given by Junker's apparatus. Some surgeons undertake a preliminary tracheotomy, and plug the pharynx, in order to prevent the entrance of blood into the air passages, but such is scarcely necessary or desirable if good assistance is to hand, since it increases to a certain extent the risks of the operation. The proceeding may be described in stages as follows : AFFECTIONS OF THE LIPS AND yAWS 745 Stage I. : Incision and Reflection of the Soft Structures of the Cheek. — The central incisor tooth of the affected side having been extracted, the upper lip is divided in the middle line as high as the columna nasi ; the incision is now carried round the ala and along the side of the nose, to a point half an inch below the inner canthus ; it thence extends on the same level along the lower orbital margin to a point below its outer border, or even to the zygoma (Fig. 271, A). The flap thus marked out is raised from the bone, and reflected outwards so as to clear the zygomatic eminence, the knife being carried as near to it as is considered wise, and the more important arteries secured, as they are divided, by Spencer Wells' forceps. Stage II. : Division of the Bony Attachments. — A keyhole-saw is now passed into the nose, and the alve- olus and hard palate divided from before backwards through the empty socket of the central incisor tooth. There is no need to incise the muco-periosteum previously, as is sometimes recommended ; division by the saw causes less bleeding than the use of the knife. The side of the nose is then freed from its bony attachments, and the periosteum stripped from the floor of the orbit, the eyeball being protected by a spatula. It is most desirable that the orbital periosteum should be preserved intact, so as to prevent septic invasion of the orbit. The nasal process of the superior maxilla is now cut through with a saw, and also the malar bone divided so as to open into the spheno-maxillary fissure. The surgeon then takes a pair of long-handled cutting pliers, and completes the division of each of these bony attachments, but reversing the order, dealing with the malar bone first, next with the nasal attach- ments, and finally with the palate. The cutting pliers must always be applied with the smooth surface towards the tissues which are to be left, and the bevelled surface towards the part which is to be removed (Fig. 272). When the section of the palate is completed, the cutting pliers are used as a lever to prise the bone out of its bed, the sound bone acting as a fulcrum, the posterior attachments being thus fractured. The pterygoid processes are broken through close to their origin from the sphenoid, and the lateral mass of the ethmoid yields along the inner orbital margin. Fig. 271. — A, Incision for Re- moval of Superior Maxilla ; B. for Removal of Lower Jaw; C. for Kocher's Operation for Removal of Tongue. 746 A MANUAL OF SURGERY Stage III : Removal of the Bone and Tumour. — The bone is now seized by lion forceps, one blade holding the alveolus, and the other the infra-orbital border, and twisted out ; the mouth is gagged open, and the soft palate, if free from disease, is divided from its attachment to the hard by a transverse incision, and all other muscular connections severed. Some care is needed in the removal of the projecting hamular process. Considerable haemor- rhage may occur at this stage from some of the branches of the internal maxillary artery, especially the infra-orbital and posterior palatine ; it is checked temporarily by plugging the wound firmly with a sponge, and subsequently the chief vessels Excision of the Superior Maxilla. are secured by ligature, whilst smaller bleeding points may be touched with the cautery. Any outlying portions of the tumour are now dealt with, and the cavity, after being dabbed over with a solution of chloride of zinc (40 grains to the ounce), is plugged with strips of cyanide gauze soaked in the iodoform glycerine emulsion. The wound in the cheek is closed, the greatest care being taken to obtain accurate apposition of the flap, especially at the lip margin, and dressed with gauze secured with collodion. In the majority of cases there is comparatively little shock, and the patients do remarkably well — at any rate, for a. time — although, unfortunately, recurrence is only too likely to follow. The plug in the nose is left in situ for twenty-four hours, and then removed through the mouth, and the wound irrigated with some antiseptic solution. The plug may be replaced, but can usually be dispensed AFFECTIONS OF THE LIPS AND JAWS 747 with if the patient washes out the cavity several times a day. Healing is effected by granulation, and of course a large gap communicating with the mouth remains. This can be sub- sequently remedied by an obturator, to which is attached a cheek- plate to prevent falling in of the cheek. The patient is fed for the first few days by the rectum, or by a tube passed into the pharynx, but soon acquires the knack of swallowing fluids, especially when the soft palate has been left intact. Partial Operations. — Many modifications of the above may be undertaken in order to minimize, as far as possible, the amount of tissue removed, and to prevent any unnecessary scarring. When the alveolus alone needs removal, the external incision may be limited to division of the lip, the soft tissues of the cheek being stripped up as far as necessary from the bones. If part of the body of the bone requires removal as well as the alveolus, only the nasal half of the incision need be made, and indeed, wherever it is possible, the orbital plate should be left in order to prevent displacement downwards of the eye and subsequent diplopia. In such cases a saw is carried from the anterior nares across the front of the antrum to the malar bone. The alveolus and palate are now divided, and the growth with this portion of bone detached from its posterior connections. The upper part can also be re- moved separately, the palate and alveolus being left intact; the operation should, in fact, never be looked upon as a fixed and definite proceeding, but may be modified to suit the particular exigencies of the case. Various forms of osteoplastic resection of the superior maxilla required for the treatment of tumours of the naso-pharynx are mentioned later (p. 766). Tumours of the Lower Jaw. These are similar in character to those met with in the upper jaw. Thus, Chondroma, Osteoma, Fibroma, and the simple and malignant forms of Epulis, have been already described. Dentigerous Cysts form around teeth which are so misplaced that they cannot erupt ; though occasionally seen in the upper jaw, they are much more common in the lower. Their characters and nature have been already described under the title of follicular odontomes at p. 171. They are met with in young people, and give rise to expansion of the jaw (Fig. 273) ; the tumour thus formed is at first hard and solid to the touch, but later on egg- shell crackling and even true fluctuation are observed when the encasing wall has become thin or absorbed. Irregularity in the line of the permanent teeth may sometimes be noted, but not necessarily, since the milk tooth corresponding to that which is misplaced is not always shed, owing to the absence of pressure from below. Occasionally suppuration within the cavity may be caused by an extension of inflammation from the fang of a neigh- 74 8 A MANUAL OF SURGERY bouring tooth, or by the cyst being opened during its extraction. A sinus discharging offensive pus will then form, and the surrounding tissues become red and congested. Treatment con- sists in freely opening the cyst through the mucous membrane, and removing a sufficient por- tion of the bony wall to allow of the removal of the misplaced tooth. The cavity is left open and allowed to heal by granu- lation, during which process strict attention to cleanliness must be observed. Fibrocystic Disease of the Jaw (epithelial odontome, p. 171) has been already mentioned as characterized by the formation of a tumour, often of great size, which consists of spaces lined with cuboidal epithelium, and supposed to originate from the enamel organ (Fig. 274). It occurs most frequently in young people, and, as a rule, runs a perfectly benign course, although when of large size it may lead to „ serious results. The only Treat- Fig. 273. — Dentigerous Cyst, show- , ... , . ing Expanded Condition of the mmt consists in complete re- Lower Jaw, and Unerupted Tooth moval of the affected portion of LYING HORIZONTALLY WITHIN IT. the jaW. (College of Surgeons' Museum.) Myeloid Sarcoma is met with in the lower jaw, not only in the form of a malignant epulis, but also occasionally as a central growth, usually attacking the median portion of the bone, which becomes expanded in the same way as when a similar disease invades the end of a long bone. It presents but slight evidences of malignancy, and may be treated in the first place by opening the outer shell of bone and scraping away the soft contents, the cavity thus formed being swabbed out with pure carbolic acid, and plugged with gauze. Should it recur, the affected portion of the bone must be removed. Whenever possible, a bridge of osseous tissue is left so as to connect the two segments of the jaw ; if this is not attended to, they are likely to fall together, and lead to considerable trouble. If the whole thickness of the bone is excised, a wire frame or splint should at once be introduced between the fragments with the same object. It is replaced later on by a suitable plate carrying artificial teeth. AFFECTIONS OF THE LIPS AND JAWS 749 Round- or Spindle-Celled Sarcoma also occurs, usually springing from the periosteum, the deeper parts undergoing ossification. The course is typically malignant, and free removal of the affected portion of the bone must be undertaken. Epithelioma invades the lower jaw as an extension of a similar affection arising either from the gum, lips, or tongue. Excision of a portion of the bone together with the primary disease is always required, unless it has extended so far as to render extir- pation impracticable. Excision of the Lower Jaw is employed in the treatment of various tumours arising from that bone, as also sometimes for extensive necrosis. In the latter case it may be possible to deal with it from the mouth, but when required for the treatment of malignant disease an external incision is absolutely essential. u Fig. 274. — Fibro-Cystic Disease of the Lower Jaw. (By kind permission of the Council of the Royal College of Surgeons.) If the whole of one side is to be removed, an incision is made, reaching from just below the red margin of the lip downwards to a point immediately below the symphysis, and thence along the under surface of the body of the jaw as far as the angle ; it is then prolonged upwards as far as the posterior border of the vertical ramus, not extending further than the attachment of the lobule of the ear, so as to avoid the facial nerve (Fig. 271, B). When a large tumour is being dealt with, the whole thickness of the lip should be divided, and the flap thus marked out dissected off the bone, and turned outwards. Where, however, the upper portion of the lip is left, the incisions are carried down to the bone, the facial vessels being secured above and below before division. The soft parts are then freed from the outer aspect of the bone, and the cavity of the mouth opened. The central incisor tooth is drawn, and the jaw divided through the empty socket with a saw and cutting pliers. By this means the genial tubercles and their attached muscles are not encroached on, and the move- 75o A MANUAL OF SURGERY ments of the tongue are left unimpaired. The bone is seized and drawn outwards, so that its internal connections as far as the angle may be divided. It must then be firmly depressed, and the muscular attachments of the masseter on the outer side, and of the internal pterygoid on the inner, cut through. The inferior dental nerve and artery will also be met with at this stage. By still further depressing the bone, the temporal tendon is exposed and should be divided by successive touches of the knife, which is kept close to the bone. Finally, the condyle is freed after division of the external pterygoid muscle and of the ligaments of the temporo- maxillary articulation. The proximity of the internal maxillary artery to the inner aspect of the neck of the bone must be remem- bered, and hence it is important to keep the blade of the knife directed towards the bone. After haemorrhage has been arrested, the wound is stitched together and dressed with collodion and gauze ; possibly a drainage-tube may be inserted with advantage for a few days through the floor of the mouth. Considerable deformity usually results from this operation, owing to the remain- ing half of the bone being drawn across the middle line. Diseases of the Temporo-Maxillary Articulation. Acute Synovitis may supervene in the course of an attack of rheumatic fever, and is evidenced by pain on movement of the jaw, with swelling due to a serous effusion into and around the joint. Resolution usually follows, but fibroid thickening of the ligaments and impairment of movement may result. Acute Arthritis arises from pyaemic infection after the ex- anthemata, or from gonorrhoea, but may be caused by direct ex- tension of inflammation from the middle ear, as in scarlatina. It occurs in children, and is due 'to the persistence of a hiatus in that part of the tympanic plate which forms the floor of the meatus and the roof of the articulation ' (Barker). It is characterized by the usual signs of a severe localized inflammation, with the forma- tion of abscesses, and results commonly in ankylosis. Rest and the antiseptic opening of abscesses constitute the only early treat- ment, although excision of the condyle is sometimes required at a later date. Osteo-arthritis is by no means a rare affection of this joint. It is often symmetrical, and characterized by an enlargement of the condyle, which can be felt distinctly in front of the tragus, especially on opening the mouth, when crepitus is also noticed. The pain is worse at night and in wet weather, and the jaw becomes deflected to the sound side if the disease is unilateral ; when both sides are affected, the jaw is pushed forwards, and the chin prcjects. The articular cartilage undergoes the usual changes, the inter-articular cartilage disappears, and the glenoid cavity becomes enlarged and flattened, so that the eminentia AFFECTIONS OF THE LIPS AND JAWS 751 articularis is relatively less marked, thus permitting the external pterygoid muscle to draw the condyle forwards. After a time, considerable difficulty is experienced in opening the mouth, even amounting to ankylosis. Ordinary medical treatment may be used in the early stages, but in the later the condyle of the jaw should be excised, a proceeding followed by excellent results. Tuberculous Disease may arise either in the bone or synovial membrane, perhaps spreading to it from neighbouring lymphatic glands. It runs the usual course of the disease, terminating in caries of the condyle, and ankylosis after protracted suppuration ; to prevent this, excision of the condyle is indicated. Immobility or Closure of the Jaw may be caused by a variety of conditions : 1. True ankylosis of the temporo-maxillary joint, fibrous or osseous, as the result of any of the diseases mentioned above. 2. Cicatricial contraction of the soft structures either within or without the mouth, as from burns, lupus, or extensive operations in the pterygoid regions upon the roots of the fifth nerve, from cancrum oris, or very rarely from myositis ossificans. 3. Spasm of the muscles of the jaw (or trismus), due to reflex irritation, as from carious teeth, or an unerupted wisdom-tooth, or some other local lesion. It is occasionally hysterical, and is one of the early symptoms of tetanus. 4. Local inflammatory conditions often render opening of the mouth impossible, both from the pain and swelling — e.g., in mumps, parotid abscess, acute alveolar periostitis — whilst in epithelioma and various forms of tumour the size of the growth may seriously impair the mobility of the jaw. The term ankylosis can only be applied to the conditions men- tioned in the first two groups. In the others appropriate treat- ment must be instituted according to the character of the affection. Where the closure of the jaw is permanent, it may be due to osseous ankylosis, the bony masses extending not only between the articular surfaces, but also between the alveoli, or to fibrous adhesions within the joint, or to extra-articular contraction of the soft parts, the skin and mucous membrane being not only involved, but also frequently the muscles and deeper structures. Division of the neck of the bone or excision of the head may thus be impracticable, or, even if possible, is useless, since the muscles of the jaw hold the surfaces in such good apposition as to bring about a recurrence of bony union, unless obviated by implanting a flap of the temporal muscle or a vulcanite plate between the bony surfaces. Division of the intra- or- extra-buccal cicatrices is unsatisfactory, owing to their rapid re-formation. The best treatment in most cases is either removal of the vertical ramus of the jaw down to the level of the alveolus, or the plan suggested by Esmarch, viz., excision of a wedge of bone, with its apex towards the alveolar border, from the neighbourhood of the angle, 752 A MANUAL OF SURGERY and the establishment of an artificial joint at that spot. The incision should be made below and behind the angle down to the bone, from which the periosteum is stripped up, and division is accomplished by means of the saw. Excision of the Condyle of the Jaw is not always a simple operation, since the space at the surgeon's disposal is very limited, owing to the presence of the zygoma above, of the facial nerve below, of the parotid gland in front, and the external ear behind. The best incision is a curvilinear one, commencing over the middle of the zygoma, and passing downwards in front of the tragus. It should merely divide the skin and subcutaneous tissue, and the flap thus marked out is turned forwards. A transverse incision is now made through the deep fascia immediately below the posterior extremity of the zygoma, extending down to the neck of the bone, which is cleared by a raspatory and divided by cutting pliers ; the condyle is then grasped by necrosis forceps, and twisted out. But little bleeding occurs, and the wound heals by first intention except along the track of the drainage-tube, which should always be employed. CHAPTER XXVI. AFFECTIONS OF THE NOSE AND NASOPHARYNX. Affections of the Outer Nose. — Several forms of Injury, including fracture of the nasal bones and separation of the cartilages, have been already noticed (p. 439). Depression or Flattening of the Bridge of the Nose is either a result of traumatism, such as a fracture of the nasal bones, or may arise from defective growth of the ethmo- vomerine septum, due to disease either of syphilitic or tuberculous origin early in life, whilst it may also result from similar conditions occurring in the course of tertiary syphilis. If caused by injury, and dealt with promptly, it may be remedied ; but when once acquired, and especially if the consequence of disease, treatment is well-nigh impracticable. Several cases have been lately recorded, however, in which bone-grafting has been successful. An incision is made down the middle line of the nose, the soft parts are reflected on either side, and, after making a comfortable bed for it, the bone- graft is introduced, and kept in position partly by sutures, but mainly by closing up the wound in the soft tissues. In one case the patient's own fourth metatarsal bone was utilized with success, whilst platinum, gold, or celluloid frames have also been employed in the same way. Expansion of the Bridge of the Nose is always the outcome of some long-continued intranasal pressure, especially from the growth of polypi. It rarely follows the development of mucous polypi, except when they are very large and chronic, but it is not an uncommon accompaniment of the fibrous or fibro-sarcomatous variety. The bridge is flattened and bulged out on either side, giving the face an appearance justifying the name 'frog-nose' which has been applied to it. It is impossible to discuss all the different affections of the skin of the nose. Many of them are associated with the sebaceous glands, which in this region are very large and abundant. 48 754 A MANUAL OF SURGERY Thus, acne is commonly met with, arising from an inflammation of the glands after obstruction to their ducts. It is especially frequent in drinkers and dyspeptics, women addicted to tea- drinking often suffering severely. When the superficial capillaries become markedly dilated and the face readily flushes on the imbibition of hot or stimulating fluids, the term rosacea is attached to it, whilst if acne pustules are also present, it is known as acne rosacea. Sometimes the spots become much enlarged, and there is a considerable amount of infiltration of the base, a condition described as acne hypcrtrophiaim. In the most exaggerated stage the sebaceous glands become overgrown and form large protu berant nodular masses projecting from the end of the nose, and covered with red greasy skin, in which the dilated orifices of the glands are very evident, and with dilated capillaries coursing freely over them. This condition is generally known as lipoma nasi, rhino- phyma, or hammer -nose (Fig. 275). The treatment of simple acne con- sists in correcting the dyspepsia, and limiting the amount of, or interdicting entirely, alcohol or tea. Capsules of ichthyol (3 to 10 minims), may also be administered thrice daily, and soothing applications should be used locally, such as a lotion consisting of calamine, oxide of zinc and pre- cipitated sulphur, held in suspension with glycerine and lime - water. Dilated and unsightly capillaries may be dealt with by puncturing them with the galvano- cautery or an electrolytic needle. Rhinophyma requires operative proceedings ; the protuberant mass should be freely dissected away from the cartilages, and the raw surface either left to cicatrize, or dealt with by Thiersch's method of skin-grafting. Partial or Total Destruction of the Nose may result from trau- matism, but usually from some chronic inflammatory or malignant growth, such as lupus, tertiary syphilis, or rodent ulcer. Epi- thelioma sometimes attacks it, and requires total removal of the nose for its cure. In any of these conditions the resulting de- formity is so repulsive that the surgeon is certain to be asked to undertake some proceeding to remedy it. Indian surgeons have had a good deal of experience in this direction, since in that country cutting off the nose is often resorted to as a means of avenging some real or fancied wrong. Various plastic operations have been devised, which, however, we can only indicate briefly here, referring students to larger works of operative surgery for fuller details. Fig. 275. — Rhinophyma, or Hammer-nose, (Tillmans.) AFFECTIONS OF THE NOSE AND NASO-PHARYN.X 755 The chief methods of Rhinoplasty are as follows : i. The so-called Indian method* consists in the formation of a nose from a flap of skin obtained from the forehead. The flap (Fig. 276) is more or less pyriform, with the pedicle so placed as to contain one of the frontal arteries and the supratrochlear nerve. Necessarily its exact shape and size vary with the character of the defect and with the type of nose desired. Keegan, who has done some excellent work in this direction, advises that the skin covering the nasal bones, as high as the level where the bridge of spectacles would rest, should first be turned down in two flaps, using their attachment to the nasal mucosa as a hinge, so that the cutaneous surface shall look inwards and the raw surface outwards. Over these the forehead flap is placed, and there should be sufficient tissue in the nasal flaps to enable their free ends to be stitched below to the forehead flap on either side of the columna, thus completing the anterior nares. The columna itself is formed by the free end of the forehead flap. Drainage-tubes are inserted through the anterior nares and kept in position for ten to fourteen days. The lateral margins of the flap are carefully sutured to the freshened edges of the defect. When the union of the lower portion is sufficiently firm, the nose is made more shapely by partially dividing the twisted pedicle, but if possible the integrity of the frontal artery should still be retained. The wound in the forehead is drawn together as far as possible by sutures, and healing promoted later by skin- grafting. 2. In the Tagliacozzian or Italian operation (so called from Tagliacozzi, the surgeon who first proposed it) a flap of skin is taken from the arm. The pedicle must always be broad, and is left attached to the upper part of the inner aspect of the arm ; it must be so placed that it can be brought into apposition with the nasal defect without tension, the forearm and hand being fixed by a suitable apparatus above the head, and retained there until good union has been accomplished, when the pedicle is gradually divided. Absolute fixation of the arm is an essential, and as this may need to be maintained for two or three weeks, the patient needs a con- siderable amount of pluck and perseverance When the pedicle has been detached, subse- quent plastic measures are required to mould p the new tissue to the shape of the nose. 3. The cheeks have also been made use of in what is known as the French method to supply material for the nose, flaps being dissected up from either side, and united in the middle line. 4. The above operations have the great objec- tion that the new nose only consists of soft tissues, and hence is very likely to shrivel up and contract, so that all that is finally obtained is a covering for the defect, which is often quite flush with the surface. To obviate this, and to secure a bony basis for the nose, attempts have been made to utilize a finger for the purpose, and Mr. Astley Bloxam has had one or more successful cases. The terminal phalanx is removed, the soft parts split down the middle line on the palmar aspect, and the divided segments united by suture to the margins of the nasal defect. When union is secured, the amputation of the finger is completed. Naturally, where only a portion of the nose is destroyed, partial operations can be devised to meet the requirements of the case. * For full details of this plan we would refer to Keegan's ' Rhinoplastic Operations.' Bailliere, Tindall and Cox, 1900. 48—2 276. — Indian Method of Rhinoplasty, showing the Shape andPosition of the Forehead Flap. The points A and B are brought down to A 1 and B 1 when the flap is twisted into position. 756 A MANUAL OF SURGERY Examination of the Nose and Naso-Pharynx. In order to under- stand fully the diseases of the nose, it is essential that the interior of the organ be efficiently examined, and to do this three chief methods are resorted to. 1. Anterior rhinoscopy consists in the illumination of the front of the nasal cavity through the anterior nares. A good light is required, such as that derived from an electric head-lamp, and some form of nasal speculum. Perhaps Thudichum's speculum is one of the best ; it consists of two unfenestrated blades, con- nected by a U-shaped spring, which is held in the hand, whilst the blades are inserted into the nostril, the nasal vibrissas being thus held aside ; the ring and index fingers are placed one on each limb, so as to regulate the amount of tension, and prevent painful overstretching. By this or similar means one is enabled to see the anterior part of the nasal fossae, including the inferior turbinated bone and the erectile tissue at its anterior extremity. The amount of distension of the latter limits the view of other structures; if greatly swollen, it feels soft and even fluctuating, but collapses entirely on the application of a 5 per cent, solution of cocaine, allowing the free convex border of the middle turbinated bone to come into view, as also the cleft or olfactory fissure between it and the septum. The septum can also be examined, frequently showing deviations from the middle line, and thickenings or spurs of bone or cartilage, which run in an antero-posterior or vertical direction. A certain amount of erectile tissue is also present on the septum. The introduction of a sterilized probe under the guidance of the eye is of the greatest value in examining the nose. It not only serves to distinguish the different qualities of growth that can be seen, but will also give information concerning regions beyond the surgeon's eye. 2. By posterior rhinoscopy is meant an examination of the pos- terior nares by a mirror placed behind the uvula and soft palate. It is by no means easy to accomplish, and requires some dexterity and practice. The tongue should be depressed, and a small mirror, previously warmed to prevent condensation of moisture, is then passed behind the uvula, without touching it or the posterior wall of the pharynx, and by shifting its angle and position a view should be obtained of the structures exposed posteriorly. If not successful, and it is absolutely necessary to obtain a view, the fauces should be cocainized and the velum held up by some form of palate retractor, such as White's. The posterior nares (or choanae) are seen, separated by the vertical posterior free margin of the septum, and within each cavity the rounded ends of the turbinated bones with the meatuses inter- vening. The inferior meatus often looks very small owing to the prominence of the velum palati, whilst the middle meatus may be encroached on by the tumefaction of the erectile tissue AFFECTIONS OF THE NOSE AND NASO-PHARYNX 757 at the back of the inferior spongy bone. Outside the choanae are seen the yellowish openings of the Eustachian tubes, whilst above and between them Luschka's tonsil, a raised collection of lymphoid tissue in the roof of the pharynx, is occasionally observed. 3. Palpation of the Posterior Nares, with the index finger, pre- viously disinfected, will, however, give better results in the majority of cases to those who are not specially practised in the above method. The index finger is passed behind the uvula and velum, and the nares can then be well explored, and the existence of adenoids or other growths determined. Foreign Bodies are rarely impacted in the nasal passages except in children, in whom the condition is not uncommon. Any uni- lateral purulent discharge from a child's nose should suggest the likelihood of such an occurrence, peas, beads, or buttons, being the substances usually introduced. A certain amount of unilateral obstruction to nasal respiration is caused thereby, followed by a catarrhal or even suppurative rhinitis, and in old-standing cases a rhinolith or nasal calculus may be caused by the deposit of inspissated mucus upon the outer surface of a foreign body. Removal is often effected by syringing out through the unaffected nostril, the lotion rushing back through the other side, and carrying the intruding body before it. Failing this, the child should be anaesthetized and a forceps or scoop employed, the surgeon's manipulations being guided by a rhinoscope and frontal illumination. Necessarily, all instruments used for this purpose should be thoroughly sterilized. After the removal, the nostrils are carefully washed out for a few days with a weak alkaline antiseptic lotion, such as salt and water to which a little sanitas has been added. Acute Rhinitis. — Several distinct varieties of this affection are described. 1. The Catarrhal form is extremely common, constituting what is popularly known as a ' cold in the head.' Not only is the nasal mucosa involved, but the inflammation often extends to the frontal or maxillary sinuses, causing brow-ache and face-ache, whilst if it spreads to the mucous lining of the Eustachian tube, temporary deafness may ensue. In infants great dyspnoea often results owing to the extreme narrowness of the nasal passages, and this may be so marked as to interfere for a time with breast feeding. Apart from the usual domestic remedies directed to in- creasing the action of the bowels, kidneys, and skin, considerable relief can often be obtained by washing out the nasal cavities three or four times a day with a weak warm alkaline lotion containing borax and possibly a little menthol. 2. A Suppurative form arises not unfrequently as a result of acute 758 A MANUAL OF SURGERY suppuration in one of the accessory sinuses (acute empyema), and then treatment must be mainly directed to the sinus. Occa- sionally it is due to gonorrheal infection either in adults or infants, but perhaps more commonly in the latter. The discharge is abundant, and causes much obstruction to nasal respiration, whilst ulceration is likely to occur. The passages must be well cleansed with a solution of boric acid several times daily, and the interior sprayed or painted with a weak solution of nitrate of silver (gr. 5 to 1 ounce) once every day as long as the suppuration continues. 3. True diphtheria also occurs in the nasal fossae, usually as a complication of the same disease elsewhere, and requiring a similar form of treatment. Chronic Rhinitis. — So many distinct types of chronic inflamma- tion of the interior of the nose have been differentiated of late years that it is impossible for us to give more than the barest outline of them. For fuller details we would refer readers to Dr. Greville Macdonald's excellent work on diseases of the nose.* One of the forms most commonly met with is characterized by engorgement of the erectile tissue covering the inferior turbinated bone, causing considerable obstruction to nasal respiration and an abundant discharge of muco-pus. It usually occurs in patients with long, prominent noses of the Jewish type, where the nasal passages are narrow, and in consequence the air pressure is diminished ; it may be lighted up by some slight local irritant, such as a sudden change of temperature. The anterior end of the inferior turbinated bone is swollen, red, and rounded, the mucous covering being cedematous, and the mass feeling, on touching it with a probe, like a sac full of fluid. The local appli- cation of a 5 per cent, solution of cocaine causes its complete, though temporary, collapse in a few moments. If it is allowed to persist, hypertrophy of the mucous membrane follows, and in the most marked types a projecting papillomatous-like mass, almost resembling a polypus, results. It is, however, merely an inflam- matory hyperplasia, and not a new growth ; true papillomata of the nose are extremely rare. The posterior end of the bone may be similarly affected, and the mucous covering of the middle turbinated may participate in the same process. A certain amount of pharyngitis or laryngo-tracheitis may also be present. Treatment. — In the early stages all that is required is to wash out the nasal cavity night and morning with some simple nose lotion, such as borax or bicarbonate of soda (5 grains to 1 ounce). This may be accomplished either by sniffing the solution from the palm of the hand, or by using some form of nasal douche ; Basdon's douche is perhaps ihe best for this purpose. If such is * ' Diseases of the Nose.' Alex. P. Watt and Son. Second edition, 1892. AFFECTIONS OF THE NOSE AND NASO-PHARYNX 759 insufficient to give relief, or if collapse is not produced by cocaine, the surface may be swabbed over with some diluted caustic, or, better still, a point of galvano-cautery at a red heat may be run along the length of the bone. In the later stages removal of the hypertrophied excrescences by the cold wire snare, or by the galvano-ecraseur, is required. Another group of cases of chronic rhinitis is associated with collapse of the erectile tissue, and then there is but little discharge, since the exudation dries within the nasal cavities and forms inspissated crusts or scabs which are often difficult to remove (rhinitis sicca). The nasal fossae are in this case more patulous than usual, and a dry pharyngitis and chronic laryngitis are often present. Both nostrils may be involved, but occasionally the affection results from deviations of, or cartilaginous excrescences (spurs) from, the septum, and then is unilateral, the discharge coming from that side which is most patulous, whilst the narrowed side remains healthy. When symmetrical, the disease is rather due to constitutional than to local causes, occurring in weakly, anaemic women, and is to be treated by general rather than local measures. In the unilateral form, deviations of the septum from the middle line must be rectified, or the spur removed by the saw. In this way the inspired air is made to pass more freely along the narrowed healthy side, and the other nostril is dealt with by the use of weak alkaline lotions. It may be also advisable to plug the dilated side with cotton-wool for some time daily, so as to enforce respiration through the other nostril. Treatment is always likely to be prolonged, and it is possible that a daily alkaline nose lotion may be needed permanently. Stimulating applications are never borne well, and hence should rarely be ordered. Ozsena. — This term was formerly applied to any offensive muco- purulent discharge from the nostrils, whatever the cause, and thus was made to include such conditions as tuberculous or syphilitic disease of the turbinated bones or of the septum, suppuration in the accessory sinuses, the impaction of foreign bodies, or the ulceration of malignant growths. Improvements in differential diagnosis have reduced the cases of ozaena to a very small number, and the term is now limited to one particular affection, and that a special form of rhinitis sicca. The disease is usually met with in young females, and may sometimes originate from traumatism, or after one of the exanthe- mata, oris associated with inherited tuberculosis or syphilis. The nose is almost always wide and roomy, and may be of the special strumous type ; the lips are often thick and everted, and the mouth is usually held open owing to the impediment to nasal respiration caused by inspissated mucus. The fcetor of the breath is the special feature that calls attention to the complaint ; 7 6o A MANUAL OF SURGERY it is peculiarly searching and objectionable, but the patient fortunately is not cognizant of it. It is due to the decomposition of the muco-pus collecting in the nasal cavity, and although Lowenberg's diplococcus is constantly present, the causative organism has not been determined with certainty. There is not much discharge, but at varying periods large crusts come away, giving relief both to the nasal respiration and to the fcetor. Both nostrils are usually involved. On examination, the shape and size of the nares are the first things that claim attention ; vibrissae are scanty, and on inserting a speculum the unusual patency becomes evident ; in fact, after clearing away all the dried mucus and scabs, it is often possible to see the posterior pharyngeal wall, and even the orifices of the Eustachian tubes. The mucous membrane over the turbinated bones is dry, collapsed, and pale, and crusts may be found cover- ing any or every part of them. The pharyngeal wall is also dry, and may be coated with a film of inspissated mucus. No ulcera- tion is present, although the removal of the crusts may be associated with a slight amount of bleeding owing to their close attachment to the mucous membrane. The examination of a case of suspected ozaena should also include the accessory cavities of the nose, since many cases in which crust-formation is a prominent symptom are really due to an empyema of one or more of the sinuses. As to etiology, it is important to note that ozaena is never seen in patients with stenosed and narrow nostrils, and is almost always associated with wide, roomy noses. In consequence, it is difficult to obtain sufficient air pressure within them to expel the exudation arising from any ordinary rhinitis, and hence the discharge tends to collect and necessarily to putrefy. The irritation thus induced is likely in weakly children to lead to suppuration. For the same cause the mucous membrane becomes dry and the erectile tissue collapses, so that an atrophic form of rhinitis sicca results, followed in time by sclerosis and shrinking of the turbinated bones. It is always a prolonged process, although in the course of years it improves and gradually disappears. Treatment. — The first essential is to keep the nose clean and free from putrefying masses of dried secretion. This must be accomplished by irrigating the cavity once or twice daily, and preferably with warm water, to which a little alkali, such as common salt, and an unirritating antiseptic, such as sanitas, has been added. At first it is well for the surgeon to see to this him- self, but after a while the patient or her friends can be entrusted with the task. Every portion of scab ought to be removed daily, and the surface lubricated with some such application as a spray of menthol and paroleine (10 grains to i ounce). The nose should then be partially plugged with a tampon of cotton-wool, especially along the lower meatus, and if thought desirable the wool may be AFFECTIONS OF THE NOSE AND NASO-PHARYNX 761 medicated with some antiseptic. By this means a flow of mucus from the membrane is determined, and the discharge is thus rendered more fluid, and inspissation prevented. A similar end may also be obtained by partially plugging the nostril with an indiarubber tube, so as to diminish its size. The general health must be attended to, and patience and perseverance will generally be crowned with success. Operative measures are scarcely ever required in this disease, although they have frequently been resorted to most unnecessarily. Disease of the Middle Turbinated Bone and Ethmoid is sometimes the cause of an offensive purulent discharge from the nose, which is often wrongly called ozaena. It occurs in individuals of all ages and classes, arising from syphilitic or tuberculous disease, but is perhaps most commonly due to septic infection from without, the result of meddlesome and careless surgery. It must be remembered that the upper part of the nose is normally sterile, and the introduction of dirty instruments is often responsible for this affection. It commences as a submucous infiltration, usually of the middle turbinal, and thence spreads, with or without ulceration, to the periosteum covering the bone, which becomes carious or necrosed. Various parts of the ethmoid, including the cribriform plate, may also be involved, and adjacent bony cavities (antrum, frontal and ethmoidal sinuses, etc.) are filled with pus. In bad cases the venous channels in the base of the skull — e.g., the cavernous sinus — may be thrombosed and infected, and even abscess of the brain has followed. The disease affects one or both sides of the nose, perhaps most frequently but one. On examining the interior of the nostril, there is no patency of the cavity, as in ozaena, but a large polypoid mass of granulation tissue may be seen blocking the middle meatus and covered with a half-dried scab, w"hilst pus can be seen to exude from it when pressed upon ; this usually comes from the antrum or frontal sinus, the mass of granulation tissue lying both above and below the entrance. A probe passed into the mass always impinges on diseased or bare bone. When due to syphilis, distinct sequestra are usually present, sometimes involving the septum and hard palate, but the accessory cavities are not generally invaded. The Diagnosis from ozaena is made by remembering that in the latter the characteristic features are the abnormal width of the nasal fossae, the bilateral symmetry, the collapse of the erectile tissue, the more complete inspissation of the secretion, and the pathognomonic stench, which are all absent in these cases. A certain amount of odour is present, but it is mainly noticed by the patient, not so much by outsiders. Treatment consists in the removal of all dead and carious bone that can be safely dealt with, together with the destruction of all 762 A MANUAL OF SURGERY fungating granulation tissue, and the drainage of such accessory cavities as can be reached, whilst attention is given to maintain cleanliness and asepsis as far as possible. Thus, the middle turbinated bone and its accompanying mass of granulation tissue may be removed by the sharp spoon, snare, or polypus forceps. The antrum must, if necessary, be opened and drained, and the walls of the ethmoidal cells may be broken down, and exit thus given to pus. The greatest gentleness and care must be exercised when any attempt is made to deal with the roof of the nose. Nasal Polypi. — Two forms of nasal polypus are described, viz., the simple or mucous polyp and the fibrous or fibro-sarcomatous. Other malignant tumours occur in the nasal, fossae, to which, however, the term polypus can scarcely be extended ; they mainly originate from the superior maxilla. The Mucous Polypus consists of a soft gelatinous mass, which on microscopic examination much resembles myxomatous tissue, covered by ciliated columnar epithelium, and supplied freely with bloodvessels. There has been a good deal of discussion as to whether or not these polypi are really of a myxomatous nature, but the general opinion of rhinologists is in favour of the view that they are inflammatory in origin, consisting merely of cedematous hypertrophic tissue. The growths are usually situated on the middle and superior tur- binated bones ; they rarely start from the roof of the nasal fossae, occasionally in the sinuses, or at the orifices leading into them ; they hardly ever involve the septum or inferior turbinated bone. The polypoid masses are generally multiple, a large one projecting downwards and forwards towards the anterior nares, and covering or hiding a whole series of smaller ones, which readily spring into prominence when that in front is removed. They are sometimes dependent on, and kept up by, suppuration in one of the adjacent sinuses. They are usually attached by a small pedicle, and when developing in the nasal fossa are pyriform and laterally compressed. When of large size, they may protrude through the nostrils, and then the epithe- lium covering the anterior portion becomes squamous, and the whole mass firmer in texture and papillomatous in appearance. Sometimes they project backwards into the pharynx, and are then more distinctly globular and usually single. Occasionally they Fig. 277. — Mucous Polypi of Nose, springing from the back and Front of the Middle Turbinated Bone. AFFECTIONS OF THE NOSE AND NASO-PHARYNX 763 are the starting-point of a myxo-sarcomatous growth, which develops rapidly, and early tends to invade the surrounding bones. The main Symptom arising from nasal polypi is obstruction to the passage of air along one or both sides of the nose, according to the location of the growths. This is always of gradual onset, and is invariably worse in wet weather, on account of the hygroscopic property of mucoid tissue. There is often a thin, watery discharge from the nose, which may perhaps be blood-stained. The patient is unable to blow the nose, and his articulation becomes nasal in quality. On rhinoscopic examination one finds a greyish semi- translucent glistening mass occupying the nostril, and attempts to blow the nose render this more obvious. Its pedunculated nature can be easily demonstrated by passing a probe around it. When of large size, some flattening or expansion of the bridge of the nose may be caused thereby, and possibly epiphora from pressure on the opening of the nasal duct. The Diagnosis should present no difficulty to one who knows how to employ the nasal speculum. Abscess, a spur, or deviation of the septum, though causing unilateral obstruction, is recognised by the exercise of a very small amount of intelligence. (Edema- tous masses of granulation tissue, associated with tuberculous or syphilitic disease of the bones, are recognised by usually involving the septum as well as the turbinals, by the purulent discharge, by the absence of superficial epithelium, and by not being dis- tinctly pedunculated ; carious bone can usually be felt by a probe through the granulation tissue. From hypertrophy of the mucous membrane over the inferior turbinated bone, a polypus is known by the fact that it scarcely ever springs from this region, whilst the former condition is sessile, red, and diminished con- siderably in size by the application of cocaine. The Treatment of mucous polypi consists in their removal either by forceps or the snare. The former plan is usually condemned by rhinologists as unscientific and barbarous, and as utilized by many of the old class of surgeons, such it certainly was : but if employed in the way described below, it is just as efficient as the snare, and gives the patient very little, if any, more pain. Person- ally, we must plead guilty to a very distinct preference for the forceps. In undertaking avulsion by forceps, the patient is seated in a chair, and the surgeon sits or stands in front of him. The nasal cavities are fully cocainized, and the situation of the pedicle ascer- tained, as clearly as possible, by illuminating the interior and by the use of a probe. The forceps employed should be long, with delicate, though strong, blades, which are deeply serrated on either side of a median groove. They are introduced open, with a blade placed horizontally on either side of the growth, and are gently pressed upwards until the pedicle is grasped as close to the 764 A MANUAL OF SURGERY turbinated bone as possible. The blades are then closed firmly, and the polyp twisted off and removed, a certain amount of haemorrhage resulting. The same process is repeated to the smaller tumours until the nostril is clear. It may be plugged with a strip of boric lint if the bleeding continues, but such should never be left unchanged longer than twenty-four hours. The plug is then removed, and the base of the growth carefully examined and cauterized with the galvano-cautery by the aid of a nasal speculum. This cannot be so accurately accomplished immedi- ately after removal, as the bleeding interferes with clear vision. The cauterization of the base is a most important item in the treatment, as without it the growths are sure to recur. The patient should be again examined after a short interval, so that any smaller polypi which have commenced to develop may be suitably dealt with. To remove polypi with the galvanic ecraseur or snare, a speculum is inserted, and the wire loop passed round the growth so as to encircle its base, and gradually tightened until it has cut through. This plan is specially adapted to large masses which project downwards behind the palate. Whichever method is adopted, recurrences are not uncommon, and the treatment may in consequence be very prolonged ; but if the surgeon will persevere in the way described above, the disease can in time be eradicated without having recourse to such a muti- lating procedure as removal of the turbinated bones ; indeed, after such an operation, considerable trouble may arise from the nasal cavity being too patulous. A Fibrous Polypus is the term applied to a fibroma, which tends sooner or later to become sarcomatous, springing from the base of the skull, especially from the basi-sphenoid or basi- occipital. It is at first distinctly pedunculated, and is usually firm, smooth, and fleshy in character ; when of large size, it may be lobulated. The early symptoms are almost limited to those of obstruction to nasal respiration, but to this is not unfrequently added severe epistaxis, owing to the vascularity of the capsule and of the over- lying mucous membrane. As it increases in size, ulceration occurs, leading to a foetid sanious discharge, and the growth rarely remains limited to the nasal fossae. If pushing forwards, it may lead to expansion of the bridge of the nose and separation of the eyes, which may even be made to diverge ; but if backwards, it may depress the velum, and hang downwards as a naso-pharyngeal tumour. In other cases it may force its way into the orbit or any of the other surrounding cavities, or may even erode the base of the skull,' and encroach upon the cranium. It is rare for any of these latter manifestations to occur until after the tumour has taken on a distinct sarcomatous type. The disease usually attacks young people, and mainly those in the second decade of life. It progresses with considerable AFFECTIONS OF THE NOSE AND NASO-PHARYNX 765 rapidity, and the fatal issue may be due to haemorrhage, asphyxia, or cerebral complications. Treatment. — Unfortunately this condition is but rarely recog- nised in the early stages, owing to the fact that the majority of practitioners are quite unable to use the rhinoscope. We would impress upon students the immense importance of thoroughly exploring both by the mirror and the finger passed behind the velum every case of nasal obstruction or of chronic discharge from the nose. When the growth is small and polypoid, it can often be dealt with from the anterior nares by means of a galvano- ecraseur. The wire loop is inserted from the front, and hitched over the tumour, so as to encircle its base, by the assistance of the right index finger passed behind the velum. The pedicle must be divided as near the skull as possible, as otherwise recurrence is almost certain to follow. Nelaton's operation, described below (p. 766), will in some instances assist the surgeon to reach the base of the skull and deal with the tumour. In the more severe cases, where the growth has become diffuse, it is very doubtful whether much good can be done by operation, since the base of the skull is sure to be gravely affected. If treat- ment is attempted, one or other of the many plans for exploring the nose or naso-pharynx must be resorted to, and the operative measures must be modified according to the peculiar requirements of the case. Probably total ablation of the superior maxilla will give the best approach to the mass. Other forms of Malignant Disease of the Nose are met with, and may originate in any part of the nasal fossae. Squamous epithelioma is that which occurs most frequently ; the symptoms consist in the presence of a blood-stained discharge, and a certain amount of respiratory obstruction, together with pain and cachexia. The lymphatic glands at the angle of the jaw are early enlarged, and the course of the disease is usually rapid owing to the great vascularity of the part. Up to within quite a recent period such growths have been almost always looked on as inoperable, but within the last ten years attempts have been made to remove them, and although necessarily the mortality is great, and the liability to recurrence considerable, yet the results have been such as to encourage the practice of attacking the disease, even in such a difficult region to explore as the interior of the nose. Sarcoma may also commence in the nose itself, quite apart from that which originates in the superior maxilla. It gives rise to the usual signs of an intranasal growth, and may be dealt with in a satisfactory manner by local means, such as curetting and the application of caustics. Not a few cases are on record in which such treatment has proved efficacious in curing the disease. The operations which have been devised for dealing with disease of the nose and naso-pharynx are so numerous and complicated that it is impossible for us to mention more than a few of the most useful and important 766 A MANUAL OF SURGERY (a) In many cases of intranasal disease considerable assistance can be derived by opening up the anterior naves, especially when one is operating for caries or necrosis of the turbinated bones. It may suffice merely to divide one ala nasi and the attachments of the cartilages to the maxilla ; but where both sides are involved, Rouge's operation is advisable. This consists in the detach- ment of the mask of the face from the maxillae by everting the upper lip and incising the mucous membrane and subjacent tissues until the nasal cavities are opened. The septum nasi is divided by cutting pliers, and the nasal cartilages completely separated. The soft tissues of the face can then be retracted upwards, and the nasal fossae fully exposed. The bleeding is always considerable, and the space gained in children is but slight. When the opera- tion is completed, the mask of the face is allowed to fall back again into posi- tion, union occurring without difficulty, although no sutures are employed. When the upper and anterior portion of the nasal cavity is to be dealt with, Langenbeck's plan can sometimes be utilized with advantage. An incision down to the bones is made along the outer border of the nose from the root downwards and outwards towards the ala. The soft parts are retracted on either side so as to expose the nasal bone and the nasal process of the superior maxilla, a wedge-shaped portion of which can be divided by cutting pliers and prised upwards, but left with their superior connections untouched, so that after the operation they can be replaced. When the septum alone is involved in malignant disease, it is possible to deal with it by an operation, which consists in splitting the upper lip in the middle line, and carrying the incision round the ala nasi on each side so that the lower portion of the nose can be turned upwards after dividing the septum. A wedge-shaped portion is then removed from the front of the palate after detaching the muco-periosteum from its buccal aspect. An excellent approach is thus obtained into the nasal cavity, and the entire septum can in this way be removed without difficulty. The parts can be afterwards brought together quite naturally, and the deformity is very slight. (b) When the disease is located further back, originating rather in the naso-pharynx than in the nose itself, the palatine route may be used with advantage. Perhaps the best of the several suggested operations is that of Nelaton. This consists in a median section of the velum and of the mucous membrane covering the posterior half of the hard palate. A transverse incision is then made on either side of the anterior extremity of this, and two muco-periosteal flaps reflected, exposing a quadrilateral area of bone which is removed by chisel and mallet. If need be, part of the vomer is also taken away, and thus the naso-pharynx is opened sufficiently to allow of the removal of the polypus or growth. The reflected segments of the palate are subse- quently sutured together. (e) Various methods of osteoplastic section of the superior maxilla have been practised, and Langenbeck's name has been associated with one or two different plans, which are, however, only suited to particular cases of disease, and at best give but poor access to the parts behind or above the superior maxilla, whilst they usually leave extremely ugly cicatrices. Perhaps the best plan to adopt is to temporarily detach the superior maxilla from its bed, turning it outwards together with the cutaneous and subcutaneous tissues overlying it, and then, after completing the operation, replacing the bone and suturing the soft parts into position. The results of such practice have been encouraging. Adenoids. — Although it is only twenty years ago since Meyer first drew attention to this condition, it is not too much to say that at the present time a large proportion of our children and young people are subject to it in a more or less aggravated form. Adenoids are very common in children with an inherited tuber- culous history, and are of considerable importance from the results to which they give rise. AFFECTIONS OF THE NOSE AND NASO-PHARYNX 767 It has been already mentioned that the naso-pharynx is the seat of a large amount of lymphoid tissue, similar to that met with in the tonsil, which may either be distributed widely over the whole mucous membrane, or may be gathered into a special mass on the roof, known as the pharyngeal or Luschka's tonsil. Adenoids consist in a hyperplasia of this tissue, exactly analo- gous to the chronic hypertrophic form of tonsillitis, with which, indeed, it is often associated. They may occur in the form of broad, cushion-like masses springing mainly from the roof or posterior walls, or occasionally as pedunculated tumours hanging down into the posterior nares. Fig. 278 represents such a condi- tion as seen by posterior rhinoscopy. The tumours are extremely soft and vascular, bleeding very readily. In the recesses or folds between the dif- ferent portions of the mass bacteria lodge and give rise to various inflam- matory troubles, both locally, and in neighbour- ing lymphatic glands. Not uncommonly isolated masses similar in structure to the above are also to be seen on the posterior wall of the pharynx, and a certain amount of chronic rhinitis and laryngitis may be associated. The Symptoms induced by adenoids are mainly due to obstruc- tion to nasal respiration. The mouth is generally held half open, so as to allow the child to breathe through it, thereby exposing the upper central incisors (Fig. 279) ; for a similar cause he snores during sleep, and usually wakes with the mouth and tongue dry. The nostrils are drawn in, and the nose is thin and pinched, the whole aspect being very characteristic ; the children often look sleepy and half silly, and indeed may be very backward in their studies. Not uncommonly there is a certain amount of semi- purulent discharge from the nose, or it may be hawked up from the pharynx, perhaps mixed with blood. Deafness also results from extension of the catarrhal condition to the mucous lining of the Eustachian tubes, and acute or chronic otitis media may be thereby induced ; both taste and smell are sometimes impaired. The palate also becomes high and arched, owing to the defective intranasal air pressure, and as the patient grows up, the incisor 1eeth may project forwards, giving a curious rabbit-like expression to the face. The cervical glands are sympathetically enlarged, and often the seat of tuberculous disease. In bad cases which have been allowed to persist throughout adolescence considerable Fir, 27S — Adenoids as seen by Posterior Rhinoscopy. (Tillmanns.) 768 A MANUAL OF SURGERY deformity of the thoracic parietes is induced, owing to the inability of the child to take a really deep inspiration, the ribs in conse- quence being drawn in, and the spine kyphotic (Fig. 280). Physical Examination consists in posterior rhinoscopy, by means of which the growths can be seen, or in palpation of the posterior nares, a process more suitable to children, who rarely have suffi- cient control to permit of the former. On passing the finger behind the velum, the naso-pharynx is found to be occupied by a soft mass of tissue which readily bleeds, and more or less obstructs the openings of the posterior nares. jwt*^S| Bfe> w- Mm. *" '" pPP^^ I Fig 279. — Adenoid Facies. (From a Photograph kindly lent by Dr. St. Clair Thomson.) This illustration shows well the sleepy look, the pinched nostrils, the open mouth and projecting upper central incisors so characteristic of this condition. Treatment consists in the great majority of cases in removal of the adenoids by operation. If left alone, there is a tendency for these growths to gradually disappear, but during this interval development may be considerably hindered, and hence a cure by natural processes in children should never be relied on. Much may be done in milder cases, however, by enforcing respiratory exercises with the mouth shut ; and in young adults attention to the general health, combined with irrigation of the nose with salt and water, and perhaps the local application of a weak solution of nitrate of silver (5 grains to 1 ounce) to the naso-pharynx, may suffice to bring about an amelioration of the condition. AFFECTIONS OF THE NOSE AND NASO-PHARYNX -69 Operation. — Much diversity of opinion exists as to the character and extent of the operation ; some authorities consider that all that is required is to scrape the growths away with the finger-nail, and undertake this proceeding either under nitrous oxide gas, or even with- out an anaesthetic. Such a measure is, to our minds, unsatisfactory, in that the adenoids cannot possibly be entirely removed, and recurrence may ensue. As a general rule, the child should be anaesthetized with chloro- form, and if enlarged tonsils co-exist, these should be dealt with in the first place. Lowenberg's forceps, curved so as to allow of them being passed behind the soft palate, are then intro- duced with the right hand, whilst the velum is protected by the left index- finger passed behind it. The protu- berant masses are grasped and torn off, special attention being directed to clearing the posterior nares. The orifices of the Eustachian tubes are readily detected, and must not be injured. Care must also be taken not to lay hold of the uvula by mistake. The surgeon's finger-nail may be used to complete the removal of any tags of tissue that remain. Of course, there is considerable bleeding, but this quickly stops of itself, and as soon as the operation is over, the head should be turned to one side, or the child held face downwards, so as to allow the blood to run out of the mouth and nose. The after-treatment consists in washing out the nose and throat with either salt and water, or a weak solution of sanitas ; the patient is kept indoors for a few days, and only fluid food allowed. Gottstein's curette is preferred by many rhinologists, and we have often used it with advantage. Fig. 280. — Lateral View of a Child with Neglected Adenoids. (From a Photo- graph lent by Dr. St. Clair Thomson.) This is the same child whose face appears in Fig. 279. It will be seen that the chest is shallow and retracted, and the spine kyphotic. The arms are small, but the legs are well developed. Epistaxis, or bleeding from the nose, may arise from a variety of causes, including traumatism, directed either to the mucous membranes or the bones, or from the presence of ulceration or tumours. Some of these local causes are very evident, if only they are carefully looked for with a rhinoscope and frontal mirror. 49 770 A MANUAL OF SURGERY One of the commonest lesions is a small abrasion or ulcer of the septum, due to detaching by the finger a scab or dried crust of mucus which causes irritation within the nostril ; each time the nose is ' picked ' in this way bleeding recurs. Another frequent source of epistaxis is the rupture of a varicose vein in the mucous membrane of the septum ; varix occurs not unusually in plethoric individuals, and sneezing or blowing the nose violently may lead to an attack. Foreign bodies may also cause haemorrhage, as also ulceration of an angioma on the septum. It frequently occurs in young people about puberty in consequence of local disturbance in the vascular arrangement of the parts ; again, cerebral conges- tion may induce it, owing to the communication by means of emissary veins between the interior of the skull and the venous plexuses in the nose ; excessive changes in the atmospheric pressure, as in mountaineering, may lead to epistaxis, whilst in 5 Fig. 281. — Belloc's Sound. abnormal states of the blood it may be associated with haemor- rhage elsewhere, as in haemophilia, purpura, and scurvy. One or both nostrils may be the seat of the bleeding, and it may be so excessive as even to threaten life. Treatment. — It must not be forgotten that, in the majority of cases, there is some local cause of epistaxis which can be found and treated directly — a fact which once more emphasizes the necessity for gaining a mastery over the use of the rhino- scope. The bleeding is generally unilateral, and in nine out of ten cases the source is within easy reach of the anterior nares, and hence in many instances all that is required is to grasp the nostrils firmly, and thus allow the blood to collect within, and give it an opportunity of clotting. At the same time, the patient should sit up, and cold be applied to the root of the nose, or to the nape of the neck. If on examination the bleeding point is detected, whether it be a varicose vein or an ulcerated surface, the haemorrhage can almost at once be stayed by applying a pointed galvano-cautery, or by sealing the spot with a swab soaked in a solution of chromic acid. Failing these measures, the nostrils may need to be plugged, but such a proceeding ought to be seldom resorted to ; it is practically a confession of want of AFFECTIONS OF THE NOSE AND NASO-PHARYNX 771 skill in the use of the rhinoscope. It may suffice merely to stuff the anterior nares with long strips of boric lint, but, as a rule, the posterior nares also require plugging. For this purpose Bellocq's sound (Fig. 281) is usually employed in order to pass a thread round the base of the palate, and out of both nose and mouth ; but where it is not obtainable, a suitably curved pair of laryngeal forceps or a catheter may be used instead. To the lower end of this thread a pledget of lint about 1^ inches by 1 inch in size is attached, and this, guided by the finger round the soft palate, is drawn tightly forwards into the posterior nares, whilst the two ends of the thread are tied together round the upper lip to prevent it from slipping. The plug is retained for twelve hours, and then removed, and the nasal fossae irrigated with a weak warm alkaline antiseptic lotion in order to prevent sepsis. Another method of arresting epistaxis is by Cooper Rose's inflating plug ; it consists of a piece of gum catheter, surrounded by a thin indiarubber bag, which can be inflated through the hollow stem. It is oiled and passed well into the nose from the front ; the indiarubber bag is then inflated to the required extent, the air being retained by a stop-cock. This generally acts most efficiently, and can be introduced and removed with scarcely any pain to the patient. 49—2 CHAPTER XXVII. APFECTIONS OF THE MOUTH, THROAT, AND OZSOPHAGUS. Stomatitis, or inflammation of the mucous membrane of the mouth, is by no means uncommon, especially in children. i . Simple Catarrhal Stomatitis results from mechanical irritants, such as roughened teeth, from irritating chemicals, or from that septic form of inflammation which is so liable to follow operations involving the mouth. It may also arise in the course of fevers, and in conditions of debility such as follow measles and other exanthemata in children ; or be associated with disturbances in the alimentary canal, as by improper feeding, dyspepsia, etc. The mucous membrane becomes hyperaemic and swollen, usually in small localized patches, which may gradually spread and become confluent, involving nearly the whole of the oral cavity. The exudation of mucus is increased, and becomes viscid and turbid, whilst the epithelium, at first white and sodden, is after a while rubbed off, leaving superficial erosions or distinct ulcers, which are very painful. The treatment consists in the removal of all sources of irritation, and the administration of drugs to correct intestinal derangements. Chlorate of potash, possibly com- bined with dilute hydrochloric acid, is very useful, both locally and internally. In the more severe cases antiseptic mouth- washes should be employed, such as the liquor soda? chlorinatae (i ounce to i pint of water), sanitas (i in 10), boro-glyceride (i in 20), etc. 2. Aphthous Stomatitis occurs in badly-fed children, in the form of small whitish spots on a hyperaemic base, which run together, and produce ulceration. Attention must be directed to the general condition, and a little borax and honey or a solution of boro-glyceride (1 in 20) applied locally. 3. Thrush, is a very singular condition, but due to the presence of a parasitic fungus, the Oidium albicans. It occurs in patches somewhat resembling curdled milk in appearance, and requires the same treatment. In both these types there is often considerable AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS 773 enlargement of the lymphatic glands, which, however, frequently subside without suppuration on removal of the cause. 4. Gangrenous Stomatitis is much the same in origin as the preceding, but more acute in its course. It occurs in debilitated children or elderly people, the subjects of albuminuria or diabetes, and is usually due to foul and dirty teeth. The gums and adjacent tissues become gangrenous, and severe toxic symptoms result. Active treatment by scraping and the use of antiseptics, such as peroxide of hydrogen, is urgently necessary. In children this condition is known as Canerum oris (p. 83). 5. Mercurial Stomatitis may arise during the administration of a course of mercury, or occasionally from a single dose in persons who are sensitive to its action. It is increased in severity if the mouth and teeth are dirty, or if the patient smokes to excess. The gums are swollen and tender, bleed on pressure, and are very pain- ful, especially when biting, or drinking hot fluids. The teeth may become loose and fall out, whilst the alveolar borders may be laid bare and necrose. The tongue is sometimes swollen and inflamed ; salivation is a marked symptom, and the breath becomes very offensive. Treatment. — Either leave off the mercury, or at any rate reduce the dose considerably, and administer saline purgatives. Chlorate of potash, combined with alum, dilute hydrochloric acid, or tincture of myrrh, may be useful locally. 6. For Syphilitic Stomatitis, see Chapter VI., p. 127. The buccal mucous membrane is also involved in the course of other diseases, e.g., diphtheria, scarlet fever, and erysipelas, but special descriptions are not needed here. Affections of the Tongue. Congenital Abnormalities. — (a) The tongue has been entirely absent. (I)) One half of the tongue is defective in size (hemiatrophy), (c) Tongue-tie is said to be present when the fraenum is shorter than usual, causing the tip to be depressed and fixed in the floor of the mouth so that it cannot be protruded. Sucking becomes difficult in such a condition, and when it is allowed to persist, there is often a lisp in the speech. Treatment is only needed in the severer forms, and consists in raising the tongue with the index and middle fingers placed one on either side, and snipping the fraenum, thus put on the stretch, across its centre with a pair of blunt-pointed scissors, (d) The tongue may be adherent to the floor of the mouth, being bound down by folds of mucous membrane (Ankyloglossia). This may also exist as an acquired condition due to cicatricial contraction after ulceration. In con- genital cases the adhesions are but slight, and the organ can be readily freed ; in the acquired condition this cannot always be accomplished, (e) The fraenum and tongue are occasionally too long, allowing of increased mobility, and even fatal results have 774 A MANUAL OF SURGERY occurred from the organ rolling backwards and impeding respira- tion. (/) The tongue may be cleft, presenting a bifid appearance ; this may be complete or partial, and is usually associated with a congenital fissure through the lower lip and mandible, (g) Macvo- glossia (or large tongue), although sometimes acquired, is usually a congenital deformity. The organ is enlarged in all directions, and protrudes from the mouth, so that the teeth indent it, and cause ulceration and considerable interference with the venous return. It thus becomes purplish and dry from exposure, the mucous membrane looking almost like skin, although saliva dribbles freely from beneath it. In old-standing cases the teeth are dis- placed outwards and the jaws deformed, so that, even if the tongue is reduced to its normal size by treatment, it may be impossible to close the mouth. Pathologically, it is due to diffuse overgrowth of the connective tissue, secondary to lymphatic obstruction and dilatation. Recurrent attacks of lymphangitis add to the trouble, the tongue gradually increasing in size, and the disease has been known to terminate in the development of a lymphosarcoma. The treatment consists in excision of a V-shaped portion, suturing the raw surfaces subsequently with catgut. Wounds of the tongue are usually caused by the teeth, especially during an epileptic seizure, or in children as a result of falls with the tongue out. There is often brisk haemorrhage for a few moments, which soon ceases, though blood may be extravasated into its substance, and cause considerable swelling. In simple cases the wound should be examined and purified, and the mouth constantly cleansed with mild antiseptic lotions; a few points of suture may also be inserted if necessary, but the wound must not be entirely closed, or tension from sepsis will result. When smart arterial bleeding is present, the mouth must be opened, the tongue pulled forwards, and the wounded vessel sought for and tied. Failing this, the lingual artery may be tied in the neck, or even the external carotid. Acute Superficial Glossitis occurs as part of a general stoma- titis, and needs no special notice. Acute Parenchymatous Glossitis, or acute inflammation of the tongue, may arise from penetrating, and of necessity septic wounds, or from the bites or stings of insects, or may be asso- ciated with acute stomatitis in the course of fevers, but is most commonly due to the injudicious administration of mercury. The condition may be limited to one half of the organ, but when arising from general causes is bilateral. The tongue becomes painful, swells up rapidly so as to fill the mouth, and even protrudes beyond the teeth, the pressure of which leads to superficial ulceration. The salivary glands are enlarged and painful, and salivation is a marked feature in the case. Speech, swallowing, and even respiration are much interfered with, and there may be considerable febrile disturbance. The case, if treated with care, AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS 775 usually ends in resolution ; but diffuse or localized suppuration may ensue, as well as the most urgent dyspnoea, arising either from cedema glottidis or from the pressure of the enlarged organ. Treatment consists in stopping the mercury, or removing any evident cause, and in the administration of saline purgatives with chlorate of potash. Leeches may be applied beneath the angles of the jaw, but in bad cases a free incision into the dorsum should be made on either side of the median line to give exit to the effused fluids and blood. The most rapid relief to the symptoms is thereby obtained, although the organ may remain enlarged for some time. If asphyxia is threatening, high tracheotomy or laryngotomy is required. Abscess of the tongue may result from the acute process described above, but it is more usually of a chronic nature, and situated at the anterior part of the organ. It is usually due to the admission of micro-organisms through some superficial lesion which has quickly healed. It presents as a tense swelling, fluctuation in which may be masked by the amount of inflam- matory thickening which surrounds it. A free incision both settles the diagnosis and cures the case. Chronic Superficial Glossitis is an interesting and important disease, which may be associated with a similar condition of the mucous membrane lining the interior of the cheeks and lips. It is most commonly due to syphilis, occurring as a tertiary pheno- menon, but may arise from excessive smoking, ragged and rough teeth, or spirit-drinking, chronic dyspepsia, perhaps of a gouty nature, being also present in many cases. It is very liable to be followed by epithelioma, Barker stating that out of no cases he carefully investigated cancer occurred in 43. For purposes of description it is useful to divide the disease into the following five stages, although it must be clearly under- stood that they are artificial, and several of them may be present in different parts of the same tongue, (i.) The papillae become enlarged and swollen, leading to the appearance of red hyperaemic patches, which cannot be recognised for certain unless the tongue is thoroughly dried with a handkerchief, towel, or piece of clean blotting-paper, which must not be carelessly dabbed over the organ, but should be firmly pressed down upon it so as to absorb all the moisture, (ii.) Overgrowth of epithelium follows, and as it increases in thickness, it becomes opaque and horny, so that the red patches are replaced by white ones, leading to the appear- ance which has been designated Leucoplakia. Sometimes the papillae become much enlarged, and stand out definitely and separately from the organ ; or the whole surface may be covered with dense white patches. To this condition the term Ichthyosis has been applied, (iii.) Later on, the excess of epithelium is shed, leaving red smooth patches in which the papillae are atrophied, or have entirely disappeared. If this occurs over the greater part of 776 A MANUAL OF SURGERY the organ, the glazed red tongue so characteristic of tertiary syphilis is produced. If, however, this process only occurs in smaller areas intermixed with portions covered with white epithelium, a patchy appearance of the tongue results, wrongly termed Psoriasis lingua', (iv.) At varying periods of the disease, sometimes earlier, sometimes later, the organ becomes ulcerated, cracked, or fissured in a somewhat characteristic manner. A median fissure is usually seen running down the middle, and from this furrows extend transversely, dividing the surface into rectangular compartments. These fissures are not always due to the cicatrization of cracks, as when opened out healthy papillae are seen at the base, and no sign of superficial scarring. They are, then, evidently the result of the contraction of deep sclerosed tissue in the substance of the organ. Superficial ulceration often occurs, apart from these fissures, being probably due to some local irritation, or to smoking ; the atrophic condition of the mucous membrane explains the great liability to this occurrence, (v.) Still later, epithelioma may develop, and usually in connection with one of the cracks, or of the cicatrices arising therefrom. It is often somewhat slow in its progress, owing to the amount of sclerosis induced by the preceding inflammation. All these stages of the disease are accompanied with much discomfort, the tongue being sometimes so tender that the patient cannot drink hot fluids, or take condiments or stimulants with- out pain. The speech, too, is interfered with, becoming thick and indistinct. The course of the case varies considerably, and if cancer does not follow, the affection usually settles down after a time, and causes but little discomfort, so long as the patient conforms to the restrictions as to diet, etc., which are essential. The treatment of the case is usually a matter of some difficulty. All sources of irritation are excluded from the mouth as a first precaution. Thus, smoking or chewing tobacco must be rigidly prohibited. Spirit-drinking and all acid wines which cause pain should be forbidden, dilute whisky and water being perhaps the best stimulant. The teeth must be well-brushed night and morn- ing, and all stumps and rough excrescences removed. Condi- ments, such as mustard, spices, curry, and cheese, are excluded from the dietary, and only simple unirritating ingesta allowed. The mouth is washed out frequently with an alkaline lotion, e.g., bicarbonate of soda (20 grains to 1 ounce), or borax (10 grains to 1 ounce), especially after meals, so as to exclude all risk of acid fermentation in the debris of food. A solution of perchloride of mercury (2 grains to 1 ounce) may be painted on twice daily when the organ is cracked or ulcerated, and in the latter case powdered calomel dusted on once a day may be beneficial, or the sores may be touched with solid nitrate of silver. General antisyphilitic remedies are employed where necessary ; AFFECTIONS OF THE MOUTH, THROAT, AND CESOPHAGUS 777 the digestion is attended to, and if the new formation of epithelium is excessive, arsenic may be administered. On the appearance of definite epithelioma suitable operative measures must be instituted. Ulceration of the tongue arises from a variety of causes, and occurs in many different forms. Thus, writable ulcers are due to rough and carious teeth. Dyspeptic ulcers are associated with gastric disturbances ; they are usually located on the middle of the dorsum, and are. often very painful. It is sufficient to touch them with lunar caustic after dealing with the cause. Tuberculous ulcers are not common, and are always secondary to pulmonary phthisis, the organ being infected by the sputum. They com- mence in the form of a submucous abscess, which bursts and leaves a small painful sore, rarely situated on the posterior part of the organ, but chiefly at the sides or on the dorsum near the tip. Secondary abscesses form around and coalesce with the original ulcer. Treatment is chiefly needed on account of the pain and discomfort caused by them ; it consists in cocainizing and scraping the sores, touching the base with pure carbolic acid, and dressing with iodoform. Applications of cocaine may also be made before meals, as a palliative measure where radical treat- ment is not undertaken on account of the extent of the pulmonary mischief. Lupus also attacks the tongue, but is very uncommon, and almost invariably secondary to a similar affection of the skin of the face. In a case under our care it appeared in the form of an irregular granulating surface surrounded by nodulated cicatricial tissue of an exceedingly dense character. The progress was very slow, owing to the amount of sclerosis present. Treatment con- sists in scraping and cauterization. Syphilitic and cancerous ulcera- tions are described below. Syphilitic Disease of the tongue occurs in a variety of different forms. A primary sore presents a characteristic indolent and inactive surface with subjacent infiltration, and much chronic enlargement of the submental lymphatic glands, which, how- ever, do not tend to suppurate. In the secondary stage mucous tubercles, fissures, and ulcers form, and usually on the sides or near the tip. Occasionally one meets with a broad wart-like condyloma on the dorsum, which may be associated with longi- tudinal fissures ; it is sometimes termed ' Hutchinson's wart.' In the tertiary period chronic superficial glossitis may develop, as also diffuse infiltration of the organ, or gummata. Gumma of the tongue is not uncommon, occurring usually in patients under forty years of age, as a late tertiary phenomenon. It starts as a localized submucous or intramuscular infiltration near the median line, and generally towards the middle or pos- terior part. The swelling is at first hard and firm, but later on becomes soft and fluctuating, and in time the overlying mucous membrane, which was unaffected, yields, and gives exit to the 778 A MANUAL OF SURGERY characteristic contents. The ulcer thus produced is oval or round in shape, and deeply excavated, the base being constituted by a slough, looking like ' wet wash-leather.' There is but little induration either of the base or edges, and one of the most characteristic features is the fact that neither the floor of the mouth nor the base of the tongue is involved, so that the organ can be freely protruded, whilst deglutition and articulation are scarcely interfered with. The patient complains of little pain, and the submaxillary glands are only affected either as part of a general enlargement throughout the body, or from the local irritation. The progress is slow, and the effect of antisyphilitic treatment very decided, the gumma absorbing, or the ulcer, if present, healing readily, but leaving a localized area of sclerosis or a deep cicatrix, from which malignant disease may subsequently originate. The treatment consists in the administration of iodide of potassium with or without mercury, whilst the mouth is kept clean with a simple mouth-wash. Innocent Tumours are not frequent in the tongue, papilloma, cysts, lipoma, and nasvi being the chief varieties, and requiring no special treatment. Dermoid Cysts also form within or under the tongue, originating usually in connection with the thyro-glossal duct (p. 823). Cancer of the Tongue occurs in the form of squamous epithe- lioma, and is both a frequent and a very fatal variety of this disease. It is usually met w T ith in men, and may arise as a result of the irritation caused by excessive smoking, especially of cigars, cigarettes, or foul pipes. Its mode of onset varies somewhat according to the situation ; (a) It arises most commonly as an ulcer at the margin of the organ, towards the junction of the middle and posterior thirds, and is then probably due to the irritation caused by ragged and irregular bicuspid or molar teeth ; (b) it may start in a crack, fissure, or cicatrix on the dorsum, as a result of chronic superficial glossitis, or of a preceding gumma; (r) it may commence as a wart-like growth, the base of which becomes infiltrated, the tumour invading the muscular substance, and spreading to the root of the tongue ; (d) it may originate as a submucous infiltra- tion, starting as an ingrowth from the mucous membrane, with- out much external manifestation of its presence ; (e) it may first be noticed as an irregular ulcer in the floor of the mouth ; or (/) it may spread into the tongue from surrounding parts, such as the tonsil or larynx. In whatever way it starts, the same features are soon mani- fested, viz., a new growth is noticed, hard in consistence, in- definite in its extent, which may or may not be painful from the first, and which ulcerates superficially, exposing a more or less crateriform cavity, with a grey, sloughy, foul surface, readily AFFECTIONS OF THE MOUTH, THROAT, AND CESOPHAGUS 779 bleeding when touched, and discharging a foul secretion, which causes extreme fcetor of the breath. The ulcer is surrounded by an indurated mass, which gradually shelves off into the neigh- bouring healthy structures, or may be abruptly limited. Profuse salivation is produced by the irritation of the branches of the third division of the trigeminal, and all the movements of the tongue are painful and limited on account of the infiltration of the base, so that both swallowing and speech are difficult, the patient allowing the saliva to dribble out of his mouth. The pain is often very excessive, and usually extends along many of the branches of the fifth nerve, especially to the ear, so that sleep become impossible, and the patient's condition steadily and rapidly deteriorates. The glands under the chin and at the angle of the jaw early become involved in the disease, which ultimately attacks the glandulae concatenatae. These secondary growths are very frequently cystic in character, from the degenera- tion of the masses of epithelium formed within them ; after a time they approach the surface and burst, leaving ragged malignant ulcers in the neck. The lower jaw, moreover, is often invaded in the later stages of the disease. The occurrence of the typical cachexia is determined not only by the pain and consequent sleeplessness, but also by the inability to take sufficient nourishment, the absorption of products of putrefaction swallowed with the saliva, the excessive salivation, the occasional haemorrhages, and the extent of the secondary growths. The patient rarely lasts, apart from treatment, for more than twelve months after the disease has been first noticed. Diagnosis. — When a case is met with where the ulcer is situated at the side or base of the tongue in a patient over forty-five years of age, with the typical enlargement of the glands, profuse saliva- tion, and impaired movements, there can be little doubt as to the diagnosis. But when it is seen in the early stage, as an infiltration of a syphilitic fissure or cicatrix, or as a small wart, it may be exceedingly difficult to determine whether or not malignant disease is present. The early enlargement of the glands, the amount and character of pain, the fixity of the organ, and the infiltration of the base of the ulcer, are important guiding marks ; but in doubtful cases a small portion of the growth should be excised under cocaine, and subjected to careful microscopic examination, and thus its nature ascertained. Moreover, the administration of steadily increasing doses cf iodide of potassium will generally bring about rapid improvement in a syphilitic case, but will do no good to an epithelioma, except perhaps temporarily when the two diseases co-exist. Treatment. —The only hope of curing the patient lies in thorough and early removal of the growth, which it must be remembered, has probably extended much further than one expects. Hence, 7S0 A MANUAL OF SURGERY no halt-measures should be adopted, but complete operations, including also the lymphatic area, are desirable. Ligature of the lingual artery and division of the gustatory nerve have been performed in cases where the disease had pro- gressed too far to attempt radical treatment, with the double object of starving the growth and relieving the pain ; such, however, are of little value. Dusting the surface of the tumour with pyoktanin will perhaps give the most relief to the unfortunate patient. Many operations for removal of the tongue have been suggested and practised from time to time, the majority of which have, how- ever, fallen into disuse, and will not even be noticed here. We shall merely indicate the chief plans of treatment adopted at the present day. For practical purposes, the cases may be divided into two groups — those in which the disease is limited to one portion of the tongue, and the muscular tissue is not extensively invaded ; and those in which glands or other structures are also obviously involved, or the tongue itself is widely infiltrated. In the first class of cases an intrabuccal operation will often suffice, combined with separate removal of the glands ; in the second, more extensive extrabuccal procedures are required. The Intrabuccal Method now adopted for partial removal of the organ is that known as Whitehead's Operation. The lingual artery should always be previously secured in the neck (p. 285), thus giving the surgeon an opportunity of removing the submaxillary gland, with its associated lymphatics, which are so often affected. The mouth is then well opened with an efficient gag, and the chloroform administered by means of Junker's apparatus. A good assistant is necessary in order to prevent blood entering the larynx, small pieces of sponge held in smooth-nosed, long- handled forceps being used to clear the pharynx. A coarse silk thread is passed through each half of the tongue to draw it forwards and steady it, and if portions of both sides are to be removed, a silver wire or silk thread should in addition be passed through the base not far from the epiglottis so as to command the stump. The essential feature of the operation is to carefully snip through the organ little by little by means of long-handled, straight, blunt-pointed scissors, picking up all the vessels as they are divided, and by this means the loss of blood is reduced to a minimum. The modus operandi for partial removal of one-half is as follows : The tongue, being drawn out of the mouth by the two anterior loops of silk, is carefully divided down the middle line into two segments, which are readily separated from one another by the finger, the scissors merely dividing the mucous membrane. The base of the organ is freed by cutting through the line of attachment of the mucous membrane to the alveolus, and then along the middle line of the floor of the mouth to the tip of the tongue, so that the sublingual salivary gland can be also taken away — a most necessary step. The mucous lining of the dorsum AFFECTIONS OF THE MOUTH, THROAT, AND CESOPHAGUS 781 is now divided transversely behind the growth, and the muscular structure of the organ slowly snipped through with scissors, and during the process, by the aid of the finger or a director, the vessels and nerves can be seen and recognised before division. Removal of the diseased half with the sublingual gland is thus easily accomplished by making the incisions meet, and dividing the intervening tissues. If the tip is alone involved, it can be removed by a V-shaped incision, made after steadying the tongue with a deep suture. The small ranine artery will spurt on each side, but is easily secured, and the gap closed by catgut sutures. If the whole tongue is to be excised, or even when one side alone needs removal as far back as the epiglottis or hyoid bone, special precautions have to be taken in order to diminish the risk of asphyxia from falling back of the stump of the organ after the operation. Thus, a thick silver wire can be passed deeply through the epiglottis, by means of which it is drawn forwards, and the wire is then fixed to the upper lip by a strip of gauze and collodion. The objection to this plan is the patent condition of the glottis, into which septic exudations from the mouth are likely to run, probably inducing septic pneumonia. A much better method is that which has been introduced and largely adopted of late, viz., the performance of a preliminary tracheotomy in order to allow the pharynx to be plugged. A Hahn's trachea-tube (i.e., a large one surrounded with compressed sponge infiltrated with iodoform, which will expand and absolutely shut off the lower respiratory tract from the mouth) is inserted, or a Trendelenburg's air- tampon ; or an ordinary tube may be employed if the pharynx is well packed with a sponge so as to prevent blood trickling down- wards ; the anaesthetic can then be administered through the tube. The advantages of this method of treatment are threefold : (a) The patient can be kept in a condition of complete anaesthesia without hindrance to the surgeon, so that the operation is more quickly finished, the shock is less, and the removal of the disease can be more thoroughly accomplished ; (b) the patient runs no danger of asphyxia during the operation by blood trickling into the lungs, or by fragments of tissue or sponge getting loose in the mouth and being inhaled, whilst later on falling back of the root of the tongue does no harm ; and (c) the chances of septic pneumonia are reduced to a minimum. Of course, opening the trachea is not entirely devoid of danger, and therefore this plan should not be adopted except where extensive dissections are called for, and then may be undertaken with advantage a few days previously. At the time of operation the pharynx is firmly packed with a sponge. Where the jaw, floor of the mouth, or glands in the neck are much implicated, or the tongue substance itself extensively infiltrated, an Extrabuccal Operation is necessary ; and of the 782 A MANUAL OF SURGERY many plans that have been recommended, we consider Kochers Operation, or some modification of it, by far the best. The incision (Fig. 271 C), commencing close to the lobule of the ear, runs down along the anterior border of the sterno-mastoid to the great cornu of the hyoid bone, and thence forwards nearly to the middle line, and upwards to the symphysis. This flap of skin and subcutaneous tissue is dissected up, and stitched to the cheek out of harm's way. If part of the jaw also needs removal, the incision may have to extend through the lower lip, and the flap is then turned outwards and backwards so as to expose the bone. All the lymphatic glands in the region — the submental, sub- maxillary, and those lying over the carotid — are now removed, as well as the submaxillary salivary gland, the lingual and facial arteries being tied close to the carotid. Any diseased portion of the jaw is isolated by saw-cuts in front and behind, and may be removed at once if desirable, or left in situ and taken away with the disease ; but, as already mentioned, it is always well, if possible, to leave a bridge of bone to maintain the continuity of the mandible. Where only half the tongue is to be removed, it is now split down the middle line with scissors, and the mucous membrane in the floor and side of the mouth divided so as to leave that side of the tongue attached merely by the muscular structures, which are snipped through with scissors, any bleeding points being secured as divided. If the whole organ is to be removed, it is unnecssary to divide it in the middle line. If the jaw is healthy, the reflection of mucous membrane is incised close to the alveolus, so that, by detaching the mylo-hyoid from the bone, a communication is made between the outside wound and the mouth, and the tongue is then drawn through this lateral opening, and removed close to the epiglottis behind, and close to the hyoid bone below, the whole floor of the mouth being effectu- ally dealt with in this way. The raw surface is painted with Whitehead's varnish (which consists of Friar's balsam, but with the rectified spirit replaced by a saturated solution of iodoform in ether), and, where trache- otomy has been performed, the mouth is plugged with aseptic gauze. The external incision is closed by a continuous suture, a large drain-tube being inserted at the lowest point for a few days. No attempt is made to keep the base of the tongue forwards, and, in fact, it is better that it should fall back so as to close, the opening of the glottis, and so prevent septic saliva from entering the air- passages ; it will be subsequently drawn forwards again by the process of cicatrization of the wound in the floor of the mouth. The plug of gauze may be removed in twenty-four hours, and replaced or not at the discretion of the surgeon. The mouth must be freely and frequently washed out with some unirritating antiseptic lotion, e.g., sanitas (1 in 10), boroglyceride (1 in 20), AFFECTIONS OF THE MOUTH, THROAT, AND CESOPHAGUS 783 boric acid (to grains to 1 ounce), or a weak solution of Condy's fluid. If all goes well, a smaller size of Hahn's tracheotomy-tube is inserted on the second day, an ordinary tube on the fifth or sixth, and even this is removed in seven to ten days. The patient is fed per rectum for twenty-four hours, but afterwards a tube attached to the spout of a feeder is introduced into the pharynx or oesophagus. In the simpler cases he is able to swallow freely and without difficulty in the course of a day or two, and even in the worst cases he can feed himself with a long tube passed into the pharynx in five or six days. Where no tracheotomy has been performed, the greatest care and watchfulness will be re- quired to prevent the stump of the tongue falling back and produc- ing asphyxia ; the mouth and pharynx must be constantly cleansed, to diminish as far as possible the risk of septic pneumonia. This operation is certainly the most successful of any for exten- sive disease, and the immediate results are satisfactory ; but necessarily where the disease is so widely diffused as to need such a severe procedure, a considerable percentage of the cases will suffer from recurrence. The great danger of the operation — septic pneumonia — is best combated by carefully cleansing the mouth and teeth previously with antiseptics, by a preliminary tracheotomy, and efficient plugging of the pharynx. Secondary haemorrhage is occasionally met with, but probably only when the patient is very exhausted at the time of the operation, and where the mouth is not well irrigated subsequently ; the bleeding vessel should be again tied on the face of the stump, or in the neck if such has not already been undertaken ; failing this, one must depend on the application of perchloride of iron or the actual cautery. Antistreptococcic serum may also be utilized as a preliminary measure in order to prevent the occurrence of septic troubles ; three or four injections of 10 c.c. each are made on the day preceding the operation, and perhaps one or two afterwards. The results obtained in this way have been satisfactory. Kocher's lines of incision may be modified according to circum- stances, provided that the essential principles are kept in view, viz., the complete removal of the primary disease and of the infected glands, and the provision of effective drainage. The removal of a part, or even the whole, of the tongue is not such a mutilation physiologically as one might expect at first. Deglutition is interfered with for a time, but the power is soon regained, and even articulation may be in great measure restored. Affections of the Floor of the Mouth. Sublingual Abscess, when acute, is due to infection of the sub- mucous tissue, as by puncture with a fishbone, or starts in a fol- licle of the sublingual or in a submucous gland. The inflammation 784 A MANUAL OF SURGERY which follows results in the formation of a puffy swelling beneath the tongue, which, if not opened early, may lead to an extension downwards of the mischief into the submental region. The tongue becomes swollen and turgid from pressure upon the veins, whilst oedematous laryngitis may also be induced. Considerable con- stitutional disturbance generally accompanies this process. A median incision through the mucous membrane, and the insertion and opening of a pair of dressing forceps, is the safest and best method of treatment, the cavity being subsequently washed out and drained. The more diffuse form of sublingual abscess is usually associated with submaxillary cellulitis (p. 93). The sublingual region is also a favourite site for Actinomycosis (p. 148), which manifests itself as a diffuse brawny induration of the tissues, progressing slowly, and not very tender. As it comes to the surface, the skin becomes red and dusky, and sooner or later a series of little pustules appear one after another with a typical yellowish apex. These burst and discharge a glutinous fluid containing the fungus, and if kept aseptic and allowed to heal, are followed by depressed and puckered cicatrices. The administration of gradually increasing doses of iodide of potassium usually suffices to bring about a cure. Cystic Swellings are not uncommon about the floor of the mouth, and amongst them the following may be described : (a) Mucous Cysts result from the distension of mucous glands ; they form small translucent swellings, elastic and fluctuating. All that is needed is to open them, and remove the anterior wall. (h) Ranula is a very similar condition, but larger and unilateral, containing a glairy mucoid fluid, and due to obstruction and dis- tension of one of the sublingual ducts (or ducts of Rivini). A similar condition has been caused in rare cases by a blocking of Wharton's duct, but this has generally been found to run along the outer surface of the cyst. The tumour may be as large as a walnut or pigeon's egg. The treatment consists in removing a good-sized piece of the wall so that the cavity may be obliterated by a process of granulation, or if that should fail, the whole cavity must be dissected out. (c) Dermoid Cysts are frequently met with in the floor of the mouth, occupying the middle line, and also projecting into the neck beneath the chin. They are due to non-obliteration of the upper end of the thyro-glossal canal (p. 823). The contents are of the usual sebaceous type. Such tumours should never be dealt with from the mouth, as they extend deeply, and need to be carefully dissected out. A free opening must be made in the middle line under the chin, and, if feasible, the whole cyst removed unopened. If it gives way, the entire wall must be dealt with, or recurrence will certainly ensue. AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS 785 Affections of the Salivary Glands. Inflammation of the Parotid Gland is met with in several different forms. 1. Epidemic Parotitis (Mumps) is an acute specific disease, usually seen in children, highly infectious in character, and generally epidemic. The period of incubation is about three weeks, and the attack itself consists in a slight febrile dis- turbance, associated with swelling of one or both parotid glands ; one gland is attacked first, becoming enlarged and tender, whilst the other side is similarly affected in a day or two. Mastication becomes difficult, owing to the tension of the parts. The swelling, which lasts for about a week and then gradually subsides, extends below and in front of the ear, and the socia parotidis can be distinctly felt lying over the masseter ; the submaxillary, sub- lingual, and neighbouring lymphatic glands are sometimes, but not frequently, enlarged. Suppuration is rare, but in adults metastatic inflammation of the testes, mammae, or ovaries is not uncommon. This complication is generally unilateral, and thus, although atrophy of the testis commonly follows orchitis, sterility is not produced. Treatment. — Keep the patient warm and quiet, and administer salines. In the later stages friction with stimu- lating liniments will hasten resolution. After the acute attack, the gland may remain enlarged for some time. 2. A Simple Parotitis occasionally results from exposure to co'.d or from injury, whilst the presence of a calculus in the duct leads to a chronic sclerosing inflammation. The symptoms consist of pain and swelling, together with a certain amount of constitutional disturbance. An extremely interesting phenomenon is the paro- titis which follows injuries or diseases of the abdominal or pelvic viscera. This condition is not very unusual, as is evident by the fact that Stephen Paget has been able to collect 101 such cases. It was formerly attributed to pyaemia, but is now considered to be due to infection of a mild type from the mouth, owing to a septic state of the teeth induced by prolonged rectal feeding. In confirmation of this view is the fact that it has been seen in not a few cases of gastric ulcer, where the patient had to be fed per rectum for some time. Treatment in these simple cases consists in the application of fomentations, perhaps medicated with bella- donna. 3. Suppurative Parotitis is a much more serious condition. It may extend from the mouth along Stenson's duct, or supervene in the course of pyaemia, or as a sequela of some of the exanthemata, e.g., scarlet or typhoid fevers. If the inflammation spreads up from the mouth, suppuration occurs primarily within the tubules ; under other circumstances, pus forms in the interstitial tissues. The gland becomes much enlarged, with congestion and oedema of the overlying skin, and, owing to the tension of the fascia, 5° 786 A MANUAL OF SURGERY exceedingly painful. For the same reason, pus cannot readily find its way to the surface, and hence is likely to burrow in various directions, e.g., amongst the muscles of the neck, or even upwards and inwards towards the base of the skull, or to the cavity of the mouth, finding its way over the border of the superior constrictor (the so-called ' sinus of Morgagni '). The constitutional symptoms from toxic absorption are usually very severe. Owing to the fact that large veins and arteries pass through the parotid gland, pyaemic symptoms are not unlikely to supervene, and the prog- nosis is therefore somewhat serious. Diagnosis. — Inflammation of the lymphatic glands lying on the outer surface of the parotid closely simulates the above affections, but is distinguished from them by the fact that they are more superficial, and that the socia parotidis is not enlarged. Treatment. — In the early stages fomentations are employed, but as soon as there is any indication that suppuration has occurred, a free incision must be made, and the pus let out. Every precau- tion should be taken to prevent mischief to the facial nerve, and Hilton's method of operating maybe advantageously employed ; but in the more severe cases where the patient's life is threatened and the pus is burrowing in all directions, the knife must be freely used regardless of anatomical considerations. Inflammation of the submaxillary and sublingual glands may arise in an exactly similar way, but no special description is called for. Occasionally, however, the process extends beyond the sub- maxillary gland to the neighbouring tissues, giving rise to what has already been described as submaxillary cellulitis, or Ludwig's angina (p. 93). Obstruction to the Flow of Saliva results from various causes, such as cicatricial contraction in the neighbourhood of the entrance of the ducts into the mouth, or from the presence of a salivary calculus, consisting of phosphate and carbonate of lime, and usually fusiform in shape. The chief Symptom of such obstruction is a painful enlargement of the gland during and after meals, which slowly passes away as the saliva finds its way past the block ; if it persists for long, the gland becomes chronically enlarged, and its interstitial tissue increased in bulk, whilst a certain amount of peri-adenitis also follows. When a calculus is present, there is usually a consider- able discharge of offensive muco-pus into the mouth. Where the obstruction is complete, a cyst may form, and if this is opened, or finds its way to the exterior and bursts, a salivary fistula results. The formation of salivary calculi is not very common in con- nection with the parotid gland, owing to the fact that the saliva excreted is limpid in character, whereas that arising from the submaxillary and sublingual glands is thick and mucoid. AFFECTIONS OF THE MOUTH, THROAT, AND (ESOPHAGUS 787 Treatment. — In cases of simple obstruction, an attempt must be made to restore the natural exit, or to make an artificial one. If a calculus is present, it can usually be seen or felt at intervals projecting from the entrance of the duct ; in such a case the duct must be incised, and the stone removed. Where, however, it is located in the substance of the submaxillary, total removal of the gland may be necessary. Tumours of the Parotid Gland are of considerable interest, and may be simple or malignant. (a) The Simple parotid tumour consists of a growth starting in the capsule or interstitial tissue of the superficial part of the gland ; it contains nodules of cartilage mixed with fibrous and mucous tissue, whilst some- times glandular elements similar to those met with in the parotid are scattered through the mass. It has been already mentioned that the cartilaginous elements are probably due to the persistence of remnants of the embryonic Meckel's car- tilage. The tumour feels hard, firm, and nodular, but where there is much myxo- matous tissue, areas of softening may be inter- spersed amongst the harder portions. The mass is situated between the jaw and the sterno-mastoid, ac- cessory processes also ex- tending over the masseter in the region of the socia, and later on burrowing deeply between the mastoid bone and the styloid pro- cess, and beneath the ramus of the jaw (Fig. 282). In the early stages the tumour is freely moveable on the deeper parts, as is also the skin over it, but subsequently the mass becomes fixed and adherent. The growth is usually slow, and at first quite painless, and there is no tendency to invade lymphatic glands or produce cachexia. Mastication is impaired in the later stages, but otherwise the subjective symptoms are of but slight impor- tance, owing to the fact that the growth is superficial to the gland, and to the more important vessels and nerves. The simple 50—2 Fig. 282. — Parotid Tumour. (Fergusson.) 788 A MANUAL OF SURGERY tumour, if allowed to persist, is not an uncommon precursor of malignant disease. (b) Malignant tumours of the parotid occur in the form of endo- thelioma, sarcoma, or carcinoma, and are not unfrequently grafted on to a simple tumour, the change of type being maiked by increased rapidity of growth and greater pain. The mass be- comes more fixed, and signs of pressure upon the vessels and nerves develop ; the facial nerve is very likely to be implicated, leading to paralysis of the face. Moreover, the skin becomes hyperaemic and often adherent to the tumour, and finally ulcera- tion and even fungation may obtain. Secondary deposits occur in the neighbouring lymphatic glands or in the viscera, and the patient soon passes into a state of malignant cachexia. Carcino- matous tumours are less common than the sarcomata, but run a similar course. The growth is an adenoid cancer, not unfre- quently of the soft or encephaloid type, and neighbouring lym- phatic glands are early invaded. The Diagnosis of simple parotid tumours from malignant growths is a matter of the greatest importance from a prognostic point of view, since simple tumours are distinctly encapsuled, and their removal, except in extreme cases, is not a matter of special difficulty ; malignant disease is much more diffuse, render- ing complete extirpation of the mass almost impracticable. The distinction between the two forms is made by a consideration of the signs and symptoms considered above, attention being directed to the rate of growth, the condition of the skin and surrounding parts, the mobility or not of the neoplasm, and the general aspect of the patient, whilst associated paralysis of the facial nerve is almost always characteristic of malignancy. The lymphatic glands lying on the surface of the parotid, when invaded by tubercle or by epithelioma secondary to some intra- buccal growth, may closely simulate a true parotid tumour, but are recognised by their more superficial position. The Treatment is often a matter of some difficulty, owing to the important character of the surrounding tissues. Removal should only be attempted if the skin is not extensively involved, if the growth is moveable on the deeper parts, and if there is no evidence of secondary deposits. Even simple tumours become irremoveable after a time on account of their deep connections and change of type, whilst it is seldom justifiable to touch malignant growths on account of their early and wide dissemination. Simple parotid tumours are dealt with either by making a vertical incision over the most prominent part of the mass, or by turning forwards a flap, exposing thereby the capsule, which is incised transversely ; for although the facial nerve is generally beneath the growth, it occasionally runs superficial to it, or in its sub- stance. After this has been accomplished, the tumour is often enucleated without much difficulty, but the surgeon must make AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS 789 certain that no deeper processes are left, or recurrence will inevitably follow. The haemorrhage from the transverse facial and other arteries is free, but easily restrained. There is no need to remove redundant skin in these cases, as it quickly contracts. In dealing with early malignant disease excision of the whole parotid gland may be occasionally undertaken. It is accomplished through a vertical incision, or, if the skin is involved, by two crescentic ones. The gland is then gradually freed from its connections, care being taken, if possible, to keep outside its capsule. It is best to deal with the lower part first, securing with double ligatures the external carotid artery and temporo- facial vein. The mass is then drawn upwards and forwards, and its deep connections severed. The facial nerve is, of course, divided, and the patient must be warned before the operation of the neces- sarily resulting facial palsy. Re- currence is almost certain to follow. Removal of the angle of the jaw as a preliminary step has been recom- mended, since considerable space is gained thereby, and a better access to the field of operation. Tumours of the Submaxillary Gland are very similar in nature to those of the parotid. Simple tumours are represented by chon- dromata, which in this position are almost always pure and without admixture of myxoma (Fig. 283). Sarcoma and carcinoma are also met with ; if seen in the early stages they are easily removed. Salivary Fistula occurs almost solely in connection with the parotid gland. It arises from penetrating wounds of the cheek dividing Stenson's duct, or more frequently it follows operations in its neighbourhood. It is a very troublesome condition, both for the surgeon who is called upon to treat it, and for the patient who suffers from the inconvenience of saliva flowing down the cheek, the amount being, of course, increased at meal-times. Stenson's duct extends forwards from the socia parotidis across the masseter muscle for a distance of about 2 inches, and then turns abruptly inwards to pierce the buccinator, and enter the mouth opposite the second upper molar tooth. The buccal and masseteric portions are almost at right angles, the latter being represented by a line drawn from the lobule of the ear to a point midway between the ala nasi and the angle of the Fig. 283. — Submaxillary (TlLLMAN.NS.) Tumour. 790 A MANUAL OF SURGERY mouth. The diameter of the duct is about one-eighth of an inch, its narrowest portion being at the orifice. Treatment. — If the buccal portion is involved, a cure is often attained by slitting up the duct within the mouth ; but when the masseteric portion is wounded, and especially if near the socia parotidis, treatment becomes more difficult. We have several times found the following plan successful : A fine probe is passed along the duct from the mouth as far as the lesion ; it is then grasped by forceps inserted through the external aperture, and drawn out on to the cheek, a proceeding sometimes facilitated by slightly enlarging the wound. A double thread of silk is now tied to the end of the probe, and drawn through the thickness of the cheek, along the buccal portion of the duct, and out of the external wound. A fine drainage-tube is then carried along the same track, and left so as to project both externally and internally, A silk thread is attached to each end of the tube, and these are knotted together round the angle of the mouth. By this means a passage is re-established into the mouth, and as soon as it becomes easier for the saliva to travel along this than along the external wound, the fistula will close. At the end of a few days the outer half of the tube is removed, and only a silk thread allowed to occupy the outer portion of the fistula, which gradually contracts so that more and more of the saliva finds its way into the mouth. The silk thread and tube are then finally removed, and if the opening in the mouth is kept patent, the external wound soon heals. In those cases where the buccal portion of the duct is completely obliterated or obstructed so that a probe cannot be passed, a trocar and cannula are inserted through the external wound and cheek into the mouth ; a silk thread is insinuated through the cannula, and a tube drawn into position, as in the former case. The subsequent treatment is the same as that indicated above. Affections of the Palate. Cleft Palate. — By cleft palate is meant a congenital defect of the roof of the mouth, whereby the structures entering into its formation do not unite in the middle line, thus allowing an abnormal communication to exist between the nose and mouth. The term does not include losses of substance, resulting from injury, syphilis, or lupus. The cleft usually starts posteriorly, and extends forwards for a variable distance, although it has been known to be limited to the anterior portion of the palate and bony alveolus, but only in exceedingly rare instances. The mildest cases consist merely of a bifid uvula, perhaps not involving the palate at all ; the next degree of severity affects the velum alone ; more or less of the hard palate may also be implicated, the cleft reaching as far forwards as the site of the anterior palatine canal (Fig. 284, B) ; whilst the severest type of the deformity AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS 791 extends in addition through the alveolus and upper lip on one or both sides, the os incisivum being in the latter case displaced forwards, perhaps on the tip of the nose (Fig. 284, C). On looking carefully at a cleft palate the defect usually appears Fig. 284. — Various Forms of Cleft Palate; A, involving merely the Velum ; B, traversing the Hard Palate as far forwards as the Anterior Palatine Canal; and C, being Complicated with a Double Hare-lip. to be mesial, but occasionally it seems as if a unilateral or bilateral fissure existed. To understand such an occurrence it must be remembered that three bony processes unite in the middle line of the roof of the mouth, viz., the two palatal pro- A B C Fig. 285. — Diagram to Show the Modifications of Cleft Palath. a, Ethmo-vomerine septum ; h, pa'atal segments; c, tongue ; d, cavity of the nose ; e, buccal cavity. cesses growing in horizontally from the maxillae, one on each side, and the ethmo-vomerine septum projecting vertically downwards from the under surface of the fronto- nasal process and base of the skull. All these should amicably join together about the ninth or tenth week of intra-uterine life. If, however, the palatal pro- cesses fail to reach the middle line, a median defect appears 792 A MANUAL OF SURGERY (Fig. 285, A), unless the ethmo-vomerine septum be so hyper- trophied as to project between them, when the appearance of a double cleft is produced (Fig. 285, B). When one division of the palate unites with the mesial septum, the other failing to reach it, an apparently unilateral cleft results ; most commonly the defect is on the left side, the vomer being attached to the right free edge, a left-sided alveolar hare-lip also complicating the case (Fig. 285, C). The reason why the anterior portion of the palate is so rarely affected without the posterior part being also involved is that the union of the various segments progresses from before backwards. The width of the cleft and the slope of the segments varies greatly in different cases. The wider the cleft, the more un- favourable it is for treatment by operative means ; and this is one of the arguments used in favour of the removal of the intermaxilla in cases of double hare-lip, so as to allow of the approximation of the two maxillae. Remove it, they fall naturally together ; leave it, and they are wedged permanently apart. As tc the slope of the segments, the more vertical they are, the more favourable for operation, since the flaps of muco-periosteum easily meet in the middle line. When the palate is more horizontal, and like a Norman rather than a Gothic arch, the flaps are shorter, and greater lateral displacement is necessary to bring their edges into apposition ; this involves much more traction on the stitches, and hence less satisfactory results. The effect of such a deformity upon the infant, from a physio- logical point of view, is very serious. The process of nutrition is considerably impaired, owing to the fact that the power of suction is lost, and fluids taken into the mouth are apt to escape through the nostrils instead of being swallowed. Consequently these children must be carefully spoon-fed with the head thrown well back, otherwise they become emaciated and succumb to inanition or intercurrent maladies. If they grow up, articulation becomes so indistinct that it is often impossible to understand what they say, the voice having a peculiar and characteristic intonation. All the letters known as explosives, whether dentals, labials, or gutturals, requiring a certain amount of air-pressure within the mouth for their due pronunciation, are difficult to produce, particularly b, d, p, t, g, f, etc. Moreover, the exposure of the nasal mucous mem- brane to the air is so much greater than usual that it is liable to catarrhal inflammation, resulting in the formation of scabs which undergo putrefactive changes and lead to a sort of ozaena. Both taste and smell are much diminished, partly from the unhealthy state of the mucous membrane, and also from the absence of an opposing surface against which the food can be triturated by the tongue. The moral effect of this deformity, particularly when associated with hare-lip, is such as to cause such patients to shun publicity from a nervous feeling of self-consciousness. AFFECTIONS OF THE MOUTH, THROAT, AND (ESOPHAGUS 79;, As to the best period at which to interfere by operation, con- siderable divergence of opinion exists. Some surgeons advocate its performance at as early a date as possible, and, in fact, it has been undertaken when the child w y as but a few days old. The success attending such practice has not been gratifying, since infants have no moral control, and are much more likely to suck at the stitches and interfere with them by the tongue, whilst the buccal cavity is small, and the tissues so delicate and friable, that the difficulty of the operation is much increased. On the other hand, it should not be deferred too long ; bad habits of articulation will be contracted, and subsequent physiological success, as gauged by the quality of the speech, is much less likely to follow. After an extended experience, it may be stated that the operation is best undertaken between the second and the third years, when a child can be easily kept under control. It is most important that the general health be good, and the mouth and throat free from local disease or inflammation. To guard against accidents it is well to make a routine practice of keeping a child under observation indoors for a few days before operating, whilst for choice the spring or summer should be selected. If the tonsils are enlarged, as is not uncommonly the case, it is by no means necessary to remove them if no active inflammation is present ; pharyngeal adenoids, moreover, may sometimes be left with advantage, as they subsequently assist in shutting off the nasal cavity during speech. Operation. — The child should be placed on a suitable table with a moveable headpiece, if possible, as it is often necessary to alter the position of the head during the proceedings. The arms are fixed to the sides by attaching them to a strap or bandage passed round the thighs below the trochanters, but the patient should not be tied down to the table, so that, although he cannot raise the hands to the mouth during the partial anaesthesia which is often present, yet he can be turned easily to either side so as to allow blood to run from the mouth. Anaesthesia is induced in the ordinary way by chloroform dropped upon the corner of a towel. The greatest care must be taken not to drop chloroform into the mouth, and for the same reason Junker's apparatus is undesirable, on account of the chloroform vapour irritating the edges of the cleft. The mouth is efficiently gagged open, and preferably by means of a unilateral instrument, which can easily be slipped in or out of position. In a case involving both the soft and hard palate there is no reason why the whole cleft should not be dealt with at one sitting. When the inter-maxillary bone has been previously removed, and a considerable gap left anteriorly, it is often only possible to close the posterior two-thirds of the cleft, either dealing with the anterior portion at a later date, or trusting to the application of a suitable obturator, to which artificial incisors can also be 794 A MANUAL OF SURGERY attached. The proceeding usually employed is practically identical with that introduced by Langenbeck, and known as uranoplasty. For convenience it may be described in four stages : Stage I. : Incision and Detachment of Muco -periosteal Flaps. — The knife should be inserted close to the last molar tooth and about half an inch from the alveolar margin, and carried forwards parallel to the teeth to a spot just anterior to the apex of the cleft ; or, if the alveolus is involved, the incision should stop behind the lateral incisor to preserve the vascular supply of the front of the flap (Fig. 286). The muco-periosteum is divided down to the bone, and by the use of a suitable raspatory the Fig. 286. — Diagram to Indicate Extent of Incisions in Uranoplasty. The thick black lines show the primary incision ; the thick dotted lines the extension backwards of the same to relieve any lateral tension ; the thin dotted lines indicate approximately the position of the free border of the bony palate. The right-hand figure shows the position of the sutures, and the condition of the parts at the close of the operation soft structures of the palate are stripped up towards the middle line, until the point of the instrument is seen protruding into the cleft. Great care is needed in dealing with the hinder part to ensure its total detachment from the hamular process and back of the bony palate, and yet not to damage it at this, its weakest spot. This must be thoroughly carried out on either side, the extent of the incisions being shown by the continuous black lines in Fig. 286. Copious bleeding always accompanies this stage of the operation, and the head should be turned on one side and lowered, and the pharynx constantly sponged so as to prevent the blood entering the air-passages. Stage II. : Paring the Edges of the Cleft. — This is accomplished by grasping the base of the uvula with a suitable pair of angular catch-forceps. Thus steadied and held, a thin paring can be AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS 795 removed, in one piece, if possible, on the side seized, and the same process repeated on the other. The paring of the edges is pur- posely deferred until after the muco-periosteal flaps have been detached, because the freshened edges do not thus get bruised by the frequent use of the sponge ; moreover, the bevel at which the edges should be pared can be more accurately estimated when the flaps have been loosened. Stage III. : Passage and Tightening of Sutures. — The simplest plan to adopt is that known as the 'loop method' of Sir \V. Fergusson, and it is carried out as follows : A long-handled palate needle with a suitable curve, and threaded with about 18 inches of fine white silk, is passed through the muco-periosteal flap from below upwards, and at a spot about 2 or 3 mm. from the margin (Fig. 287 A) ; as a rule, it is not necessary to hold the flap to effect this. The loop of silk projecting from the cleft (Fig. 287 B) is now grasped with smooth-nosed forceps and drawn out of the mouth, Fig. 287. Fig. 288. Fig. 289. Diagrams to Illustrate the Loop-method of Passing Stitches in the Operation for Cleft Palate. The needles and silk thread are, for purposes of illustration, represented much thicker than would be really employed. whilst the needle is withdrawn. A similar loop is inserted through the opposite side of the cleft at an exactly corresponding point, so that there are now two loops emerging from behind through the cleft (Fig. 287 C, D). One of these is loosely threaded through the other (Fig. 288 E), and the latter gently withdrawn, carrying with it the loop-end of the former (Fig. 288 F), and thus a double thread is carried through both sides of the palate, a loop projecting from one side, and the free ends from the other. This process is commenced anteriorly and carried backwards until the base of the uvula is reached, the stitches being inserted about half a centimetre apart, so that nine or ten threads may be needed to secure the whole palate. They are left loose, the ends being held by the anaesthetist or assistant against the cheeks until all have been inserted. A 6-inch length of fine well-annealed silver wire is successively hooked over each loop (Fig. 289 G), drawn into posi- 7y6 A MANUAL OF SURGERY tion by the silk thread (Fig. 289 H), and tightened to a suitable degree by a wire-twister, so that the pared edges of the cleft are exactly apposed. This is best undertaken from before backwards. Finally, the uvula is stitched with silk inserted by means of a double-curved needle (Fig. 289 I); silver wire would irritate the back of the tongue too much and cause vomiting. Some surgeons prefer to introduce the wire by means of a specially constructed hollow needle with a double curve, through which the wire is protruded by unwinding a drum in the handle. This is passed through both flaps, commencing at the uvula, and working forwards, tying each stitch as it is inserted. Stage IV. — It is now only necessary to take steps for the relief of all lateral tension, a most important and essential proceeding. The best way to accomplish this is to prolong backwards through the soft palate the lateral incisions already made so as to thoroughly divide the levator palati (see the thick dotted lines in Fig. 286). Occasionally the anterior and posterior pillars of the fauces, con- taining respectively the palato-glossi and palato-pharyngei muscles, will also need to be snipped across. The child should now be put to bed with the head low, so that any accumulation of blood or mucus may gravitate easily into the pharynx. The mouth can be washed out with a weak solution of sanitas, although some surgeons prefer not to disturb the parts for three or four days. No nourishment should be given for the first four or five hours, and but very sparingly for the first twenty- four. Milk and water, given by a spoon or from a feeder, will form the staple article of diet. By about the fifth day soft food, such as soaked bread and custard pudding, may be safely given. The patients are generally allowed up on the sixth day. The silver stitches may be left in for ten days or a fortnight without doing any harm. In dealing with clefts of the soft palate alone, a modification of the above operation may be performed, called staphylovraphy . The edges are first pared, lateral incisions are then made to divide the levatores palati, and the stitches finally passed and tied. Results. — It is possible that in most cases articulation will be, if anything, impaired as the immediate result of the operation, since the mechanism which the patient ordinarily employs is thrown out of gear ; subsequent education at the hands o f a voice- trainer is absolutely essential in order to correct this. Even then the unpleasant articulation occasionally persists, owing to the patient being unable to draw up the velum so as to close the posterior nares ; this is due to a reduction of the depth of the soft palate owing to the traction required to close the cleft. In spite of this, however, the operation is most beneficial in that it shuts off the nose from the mouth, prevents the dropping of mucus, improves the sense of taste, and adds greatly to the general comfort of the patient. AFFECTIONS OF THE MOUTH, THROAT, AND CESOPHAGUS 797 Mechanical Treatment of clefts in the palate by means of obturators or artificial vela is still advocated by some surgeons and dentists in preference to any operative interference. An obturator consists of an adjustable plate or plug fitted to and closing an aperture in the hard palate. It may be used with advantage in perforations due to traumatism or syphilis, and in apertures left after operations in which portions of the palate are removed, such as excision of the superior maxilla. In cases of double hare-lip and cleft palate, where the os incisivum has been extirpated, an aperture is often left anteriorly which cannot be satisfactorily closed except by an obturator, which also serves to carry the necessary artificial incisors, and may have cheek plates attached to push forwards the upper lip. For whatever purpose an obturator is needed, it should never take the form of a closely-fitting plug, which, by its constant pressure and irritation, causes the aperture to become enlarged, but always that of a plate, either of thin vulcanite or gold, which can be fixed to the teeth, and maintained in position by suction. It is sometimes found, however, that the addition of an intranasal projection to the upper surface of the plate improves the articulation by diminishing the size of the nasal cavity. An artificial velum consists of a plate obturator, to which is attached posteriorly a moveable segment to take the place of the normal velum. Such consists either of a hinged metal plate, resting on the nasal side of the segments of the soft palate, and moved by them, or of a thin indiarubber bag filled with air, sewn to the back of the obturator. They are complicated and difficult to keep in order, and, to our minds, the results of operative interference -are superior. Ulceration of the Palate occurs in a variety of forms, e.g., (a) simple, as an accompaniment of general stomatitis: (b) syphilitic, which may involve either the hard or soft palate ; if superficial, it is usually a late secondary phenomenon ; if deep, it involves the bones, and often leads to necrosis, and is then due to tertiary mischief: (c) lupoid, a somewhat uncommon condition, which may result in great destruction of tissue'; it is usually seen in children, and often associated with a similar disease of the nose, from which, indeed, it may have spread : (d) tuberculous, due to the breaking down of a tuberculous abscess under the periosteum, and then complicated with caries of the bony palate : (e) malignant, usually resulting from the growth of epithelioma, either starting primarily in the palatal mucous membrane, or extending to it from the tongue, tonsil, or upper jaw. Acquired Perforations of the Palate, though occasionally caused by traumatism or lupus, are in almost all cases due to tertiary syphilis. The ethmo-vomerine septum is often involved in the destructive process, giving rise to a most offensive discharge from the nose. If the soft palate is alone affected, the velum may become fixed by cicatricial adhesions to the back of the pharynx, and pharyngeal stenosis or considerable loss of substance of the velum results. A nasal intonation of the voice is always caused by any condition which interferes with the closure of the naso- pharynx by the velum during articulation. The treatment of these conditions should follow the usual antisyphilitic course. Perfora- tions are best remedied by the use of plate obturators. We have seen out-patients make efficient obturators out of a piece of sheet indiarubber maintained in situ by suction, or of two pieces stitched together in the middle, one piece passing above and the other 798 A MANUAL OF SURGERY below the opening. Occasionally when the aperture is small, the local disease soundly cured, and the general health good, an attempt may be made to close it by stripping up muco-periosteal flaps, paring the edges and suturing them together. The results are, however, seldom satisfactory. Any of the ordinary forms of inflammation of bone may be met with in the hard palate. Necrosis is usually due to tertiary syphilis, or may accompany acute subperiosteal suppuration, extending from an alveolar abscess. In either case the surgeon must wait till the sequestrum is loose, and then it may be re- moved. Caries is generally due to syphilis or tubercle. The following tumours occur on the hard palate. Simple epulis (p. 737) may extend from the alveolus, or an identical condition may start in the middle line. An adenoma of the palatal glands is occasionally met with. It presents as a smooth or papillated tumour, somewhat resembling epithelioma, but distinguished from it by its slower rate of growth, and the absence of ulceration, pain, or of glandular enlargement. An operation limited to the soft parts is probably all that is necessary. Sarcoma may be primary, and is then often myxo-sarcomatous in type, or secondary. In the former case it simulates rather closely a diffuse alveolar abscess, but is recognised by its slower growth, less pain, absence of inflammation, and, if need be, by the results of an exploratory puncture. Epithelioma also occurs, but is uncommon. Treatment for the two latter conditions, if limited to the palate, would consist in partial removal of the affected superior maxilla. Elongation of the Uvula is frequently the result of a chronic relaxed throat. At first it merely lasts for a time, and by the use of astringents disappears ; but later on the elongation becomes chronic, and causes great irritation of the back of the tongue and fauces, resulting in a troublesome throat-cough and even vomit- ing. Under such circumstances it should be removed. After well cocainizing the part, it is grasped by a pair of hook-forceps, which seize not only the mucous membrane, but also the muscular structures beneath, and a sufficient amount is then removed by snipping it across near the base with a pair of blunt-pointed scissors, leaving about a third of an inch of the organ behind. Affections of the Tonsils. Acute Tonsillitis results either from cold, or from the inhalation of impure air, especially when contaminated with sewer gas. It is often seen amongst the residents in hospitals (hospital throat), and may precede an attack of acute rheumatism. Three varieties are described : (a) Acute superficial tonsillitis, which consists of a slight super- ficial inflammation, the result of cold, etc., in which the tonsil participates with the pharynx and velum. There is but little AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS 79; swelling of the part, which, however, becomes red and painful, rendering swallowing difficult. Ordinary anti-catarrhal remedies are necessary, and a chlorate of potash gargle. (b) Acute follicular tonsillitis is characterized by a general en- largement of the organ, which is dusky red in colour and painful, causing obstruction to both breathing and swallowing, the tonsils, perhaps, almost meeting in the middle line. There is a good deal of yellow patchy exudation from the follicles, which may coagulate on the surface and form a false membrane, distinguished from that of diphtheria by its want of adhesion to the subjacent tissue, being readily detached by a camel's-hair pencil. The temperature is high, the glands below the angle of the jaw enlarged and tender, the tongue covered with a thick whitish fur, and the bowels confined. Such a condition may herald in an attack of so-called blood-poisoning, or septicaemia. (c) Acute parenchymatous tonsillitis, or quinsy, is a more diffuse inflammation, which is not limited to the organ, but also involves the soft palate and fauces. The swelling is more extensive, the pain is greater, and suppuration frequently results. Other symptoms are much the same as in the above. The Diagnosis must be made from scarlet fever by the absence of the characteristic rash and red tongue of the latter condition, and by the redness being more dusky and less diffuse in tonsillitis. From erysipelas of the fauces, it is known by the redness being more concentrated, the oedema less marked and more limited, by the glands at the angle of the jaw being less enlarged, and by the absence of any external manifestation of the disease. Treatment must always be commenced by a good calomel purge, which mav be followed by the administration either of salicylate of soda (20 grains, thrice daily), or of chlorate of potash and sulphate of magnesia, to which a few drops of tincture of aconite may be added if the constitutional symptoms are severe. The patient will experience much relief by inhaling the steam from hot water (150° F.), in which a little creasote or carbolic acid is dis- solved, or the tonsils may be scarified. Suppuration is dealt with by a free incision, the knife entering the most prominent part of the swelling, and cutting backwards towards the middle line ; the close proximity of the carotid should not, however, be forgotten. Hot flannels or fomentations may be applied to the neck and throat, and plenty of fluid nourishment administered. This is followed as soon as possible by iron, bark, and other tonics. Chronic Tonsillitis appears in two distinct forms : (a) Chronic inflammatory tonsillitis occurs in children whose tonsils, after one acute attack, remain enlarged, painful, con- gested, and very liable to recurrence, which often runs on to suppuration and ulceration. After a time the tonsils shrink back and atrophy, becoming hard and fibroid. (b) Chronic hypertrophic tonsillitis is met with in tuberculous Soo A MANUAL OF SURGERY children, resulting from an overgrowth of the lymphoid tissue, and is usually associated with the presence of adenoids in the naso-pharynx. The tonsils are enlarged, pale in colour, and firm in consistence ; the orifices of the crypts are very patent, and in them are often seen plugs of mucous secretion, which may become infiltrated with lime salts, forming concretions, which however, are never of any great size. The patients are very liaMe to recurrent attacks of inflammation, with or without suppuration, and even cysts may form from the blocking of the follicular ducts. When much enlarged, the tonsils may meet in the middle line beneath the uvula, causing obstruction both to swallowing and respiration. The patient usually breathes with the mouth open, owing to the concurrent naso-pharyngeal obstruc- tion, and from the same cause speaks thickly, as if he had some loose body in the mouth, and necessarily snores during sleep. Hearing is often interfered with from the mucous lining of the Eustachian tube becoming thickened and inflamed. The Treatment of these cases consists in first attending to con- stitutional weakness by removal of the patient to fresh or seaside air, and by the administration of iron and cod-liver oil ; at the same time the throat should be painted twice a day with glycerine of tannic acid, or with equal parts of glycerine and tinct. ferri per- chloridi, or touched with the galvano-cautery, Failing this, ton- sillotomy should be performed ; in children the organ may be cut away as far back as possible, but in patients over the age of twenty only a thin slice should be removed, and never the whole organ, since there is much more risk of grave haemorrhage ; the galvano- cautery is much better treatment in adults. It has also been suggested that the voice is weakened by tonsillotomy, but this is somewhat doubtful. Tonsillotomy may be undertaken in two ways : (a) By the guillotine. The fauces having been carefully and repeatedly brushed with a 5 per cent, solution of cocaine, the mouth is opened and one of the many forms of tonsil guillotine introduced ; Mackenzie's spade guillotine is as good as any. The ring of the instrument is passed over the projecting organ, external pressure behind the angle of the jaw assisting in this manoeuvre. By the pressure of the thumb the projecting mass is cut off by the sharp blade. In dealing with the right side, unless the surgeon is ambidextrous, he had better stand behind the patient's head, looking over into the mouth. (b) By the bistoury. The tonsil is seized at its lowest point and drawn well inwards by means of hooked forceps, and the pro- jecting mass removed by a straight blunt-pointed bistoury, the base of the blade being guarded, if preferred, by a piece of plaster wrapped round it. The incision should be made from below upwards, and the edge of the knife kept rather in than out, so as to avoid all risk of wounding the internal carotid, which is in close AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS Soi contiguity to the outer surface of the gland. The surgeon must stand behind the patient's head in dealing with the right side, and in front when operating upon the left. Care must be taken to include the lowest portion of the tonsil, which often hangs down into the pharynx, and is liable to be left behind. In children the hypertrophic type of enlarged tonsil may be enucleated without much difficulty by dividing the mucous membrane in front of it, and shelling it out of its bed, the posterior reflexion of mucous membrane being subsequently snipped through with bistoury or scissors. The haemorrhage, though brisk for the moment, soon ceases if care is taken not to cut too deeply, or encroach upon the sur- rounding mucous membrane. Should the bleeding continue, it can generally be arrested by douching the face with iced water, or by the local application of wool pledgets soaked in iced boric acid lotion, or in tinct. ferri perchloridi ; possibly a gargle con- taining hazeline may be efficacious in bad cases, or the galvano- cautery may be applied. This is more likely to occur in adults than in children. Syphilitic Disease of the Tonsil is met with in various stages. The primary chancre is seen occasionally, arising in one case we know of through infection from a stick of caustic which had been previously used to cauterize a syphilitic ulcer and insuf- ficiently cleaned before being applied to the tonsil, the surface of which was abraded. The glandular enlargement in the neck is very marked in such cases, and the course of the disease usually severe. Secondary ulcers of the ' snail-track ' type (plaques muqucuses) are common in this region, being usually symmetrical. In the tertiary period a diffuse gummatous infiltration occurs, involving also the palate and fauces (p. 803), and leading to pharyngeal stenosis. Tumours of the Tonsil are almost always malignant in type, but are not very common. Epithelioma occurs as a firm indurated infiltration rapidly spreading to adjacent parts, and involving the lymphatic glands. It generally starts either in the root of the tongue or in the pillars of the fauces, and presents a ragged ulcerated surface with a hard margin and sloughing base. It runs a rapidly fatal course if left to itself. Lymphosarcoma of the tonsil arises in the organ itself, usually after middle life ; it presents a smooth, dusky red appearance, the mucous membrane being stretched over it, and feels soft and almost fluctuating. In the early stages it may be freely moveable, but ere long it infiltrates surrounding structures, and affects the neighbouring lymphatic glands. Round-celled sarcoma also attacks the tonsil as a primary growth, and is less limited and defined than the former. In all these varieties the growth extends into the pharynx, impeding deglutition and respiration, and ulceration with or without serious 5 1 8o2 A MANUAL OF SURGERY haemorrhage may ensue ; indeed, the latter complication is a frequent cause of the fatal result. Extirpation of Malignant Tumours of the tonsil is often imprac- ticable from the extent of the disease, and the early implication of the surrounding structures, although it has now been shown that they are more amenable to treatment than was formerly thought to be the case. The disease may be dealt with in two ways : (a) From the mouth in the case of the loosely encapsuled and freely moveable lympho-sarcomata. The capsule is divided preferably by a galvano-cautery, and the growth shelled out some- times with the utmost ease, and with very little haemorrhage. Recurrence in the lymphatic glands is, however, almost certain to follow, (b) From the neck. The best plan is to make an incision along the anterior border of the sterno-mastoid, and carefully dissect down to the pharyngeal wall, removing all lymphatic glands, which are enlarged or suspicious, and securing the external carotid or its anterior branches. The mass is then isolated from the surrounding structures and removed. A good many cases have now been reported which were treated in this manner with complete success, even when the tongue, palate, or pharynx were invaded. It is occasionally necessary to make an incision from the angle of the mouth backwards through the cheek ; the tonsil is thus well exposed, and can be dealt with satisfactorily. The patient should always be immunized to streptococcal infection before the operation. Affections of the Pharynx. Acute Pharyngitis is usually associated with a similar inflam- matory condition of the velum palati, nasal mucous membrane, and tonsils, and results from exposure to cold, from absorption of sewer gas, and from general diseases of the exanthematous type, e.g, scarlet fever. It is characterized by redness, pain, and swelling of the mucous membrane, which becomes covered with mucus or muco-pus. An irritable cough, with perhaps sneezing, interference with nasal respiration, and great pain on swallowing, are produced by this condition, and if it spreads to the Eustachian tube temporary deafness is induced. Ulceration of the velum and fauces occasionally follows. The Treatment consists in attending to the general condition, especially if of exanthematous origin, and when due to catarrh, in administering antiphlogistic remedies (e.g., purgatives, sudorifics, and diuretics) and soothing local applications (e.g., ice to suck, chlorate of potash gargle, etc.). Great relief is often given by inhaling steam from water at 150 F. to which a little Friar's balsam has been added. Erysipelas of the Fauces and Palate has been already alluded to (p. 96). Chronic Pharyngitis is commonly met with in clergymen and AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS 803 public speakers who are called upon to exert their voices for any length of time, in costers and street-hawkers who shout their wares, and in drinkers and smokers. It may commence as a chronic inflammation, or may follow an acute attack. The mucous membrane is more or less red and infiltrated, with vessels coursing over it, and there is often a good deal of muco-purulent discharge. If the buccal side of the velum palati is affected, there is usually much less secretion than from the pharyngeal aspect, where a considerable amount of dark green viscid material may collect and cling to the pharyngeal wall, constituting scabs, which may decompose and cause the breath to be somewhat offensive. Two main varieties are described : 1. Chronic Follicular Pharyngitis, in which the lymphoid follicles scattered throughout the mucous membrane become enlarged. This is specially evident upon the soft palate, but is often greater in amount upon the upper wall and sides of the pharynx, where there is a mass of lymphoid tissue, sometimes known as the pharyngeal or Luschhas tonsil (vide Adenoids, p. 767). The uvula may be also elongated and hypertrophic in this condition. 2. Chronic Atrophic Pharyngitis is usually associated with the atrophic form of rhinitis sicca (p. 759), and possibly with chronic laryngitis. The mucous membrane is smooth, dry, and glazed, and the exudation forms adherent scabs. The throat feels dry and irritable, and the voice is often husky. The Treatment of chronic pharyngitis varies with the condition and character of the affection. If of a simple type (' relaxed throat '), all sources of irritation — such as smoking, spirits, and condiments — must be avoided, the bowels and digestion attended to, and astringent sprays, gargles or applications made use of, care being taken when necessary to apply these to the naso-pharynx by passing the brush up behind the soft palate. The most useful reagents to employ are the glycerine of tannic acid, equal parts of glycerine and tinct. ferri perchloridi, whilst chloride of am- monium inhalations are sometimes valuable, as also sprays of menthol dissolved in paroleine. When the inflammation is of the follicular type, it may be further necessary to destroy the follicles with the galvano-cautery after cocainizing the surface ; enlarged and varicose vessels may be divided in the same way. In the dry form of pharyngitis, inhalations of chloride of ammonium are recommended, or chloride of ammonium lozenges ; the nasal con- dition, however, is that which most needs treatment. Syphilitic Affections of the Pharynx may be met with in the secondary or tertiary stages. In the former they are of a super- ficial character, such as mucous tubercles, snail-track ulcers, etc. ; in the latter they appear in the shape of a dip/use gummatous infiltration, which is often of considerable consequence, both at the time an J subsequently. It manifests itself as a widespread 5 1 — 2 8o 4 A MANUAL OF SURGERY nodular thickening of the mucous membrane, especially in the neighbourhood of the fauces and soft palate, which rapidly runs on to ulceration, and may impede both respiration and deglutition. The administration of mercury and iodide of potassium usually causes a rapid improvement, but the subsequent cicatrization may bind down the velum, and lead to pharyngeal stenosis of such a character as to constitute a fibro-cicatricial septum, with an opening through it perhaps only large enough to allow a small bougie to pass. For such a condition much may be done ; the opening may be more or less dilated by careful division of some of the bands and the passage of bougies ; and the soft palate can be set free from the dorsum of the tongue. Of course there is a great tendency for the opening to contract again, and treatment by bougies must be persisted in. A localized gumma may form in the submucous tissue, not un- frequently involving the posterior pharyngeal wall, and running its ordinary course with or without ulceration. Tumours of the pharynx are rarely primary. They may extend into it, however, from surrounding parts, e.g., naso-pharyngeal polypi arising from the base of the skull, or retro-pharyngeal growths from the spine. Epithelioma either involves the pharynx primarily, or spreads to it from adjacent parts, such as the tongue or tonsil. The usual type of tumour develops with some amount of ulceration ; lym- phatic glands become secondarily affected, and the tumour gradu- ally invades surrounding tissues, although it is interesting to note that for some time it is limited to the mucous membrane, extending superficially over it, but not involving the underlying pharyngeal muscles. Death results from haemorrhage due to ulceration into large vessels, from interference with swallowing or breathing, from pressure on important nerves, or from general dissemination. Treatment. — It is only within the last decade that any attempt has been made to deal with these cases ; even now the mortality is very high, and statistics go to prove that if the operation involves removal of portions of the upper or lower jaw, a fatal issue is likely to follow. The same precautions as to cleansing the teeth, immunization to streptococcal infection, etc., must be taken, as in dealing with naso-pharyngeal or buccal growths. As a general rule, an incision along the anterior border of the sterno- mastoid is the best to employ, although occasionally a second may be required, splitting the cheek towards the angle of the jaw. The external carotid is tied, all glands are removed, and then the growth is extirpated, partly from without, partly from within. It is always advisable to perform a preliminary tracheotomy, and feeding must be undertaken for some days by means of a stomach - tube. Transhyoid pharyngotomy is a useful means of approach in some of these cases (p. 844). AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS 805 Retro -pharyngeal Abscess is acute or chronic in its course. The acute form results from infection through the mucous membrane, as by fishbones, etc. ; or arises from an inflammation of the lymphatic glands which are found in this situation in children, but atrophy in adults, and derive their lymph from the interior of the nose and naso-pharynx. The chronic variety generally follows tuberculous caries of the spine, or disease of the bones at the base of the skull. Whether acute or chronic, the abscess forms a tense elastic swelling, situated behind the posterior pharyngeal wall ; in the former case it is associated with high fever, and locally much redness and inflammatory oedema, which may even extend to the glottis, and cause dyspnoea ; in the latter, where the affection is chronic, there is less local inflammatory reaction, but signs of cervical spinal disease are present. The abscess may burst into the pharynx, or may burrow outwards on either side, being guided by the pre- vertebral fascia, and point either in front of or behind the sterno-mastoid. Treatment should never be delayed, from fear of the superven- tion of oedema of the glottis. The abscess should be opened from the neck in all cases, as then an aseptic course can be maintained, and there is no fear that the pus will enter the air-passages. If pointing in front of the sterno-mastoid, the abscess is opened in that situation ; but otherwise an incision should be made along the posterior border of the muscle, which must be drawn forwards, and the transverse processes of the cervical vertebrae defined. Possibly the abscess will be opened by the necessary manipulation of the wound ; if not, the index-finger of the left hand should be placed against the abscess wall in the mouth to guard it from injury, and a pair of sinus forceps thrust into it in front of the vertebrae by the right hand. A drain-tube is then inserted, and the case runs an ordinary aseptic course. Affections of the (Esophagus. Malformations of the oesophagus are congenital or acquired. A Congenital communication may exist between the oesophagus and trachea, either in the form of a small fistula, or the upper end of the oesophagus ends blindly, whilst the lower end opens into the trachea near its bifurcation. Life is impossible under such conditions, and the children die shortly after birth. Con- genital stricture may also be met with near the cardiac orifice, resulting in general distension and dilatation of the oesophagus (cesophagoccele). The Acquired malformations consist in the development of the so-called Diverticula. Two forms have been described by Zenker : (a) Pressure Diverticula, which are the more common, and seem to be associated with some congenital weak- ness of the wall, probably connected with the branchial clefts. They vary much in size, perhaps becoming as large as a child's head, and rarely come under observation before the age of thirty. So6 A MANUAL OF SURGERY They usually spring from the posterior wall, close to the junction of the pharynx and oesophagus, constituting sometimes what is known as a ' pharyngocoele ' ; the cavity extends downwards between the oesophagus and vertebral column. The symptoms are due to distension of the cavity with food which stagnates and putrifies, forming a swelling in the neck which can be emptied by pressure ; the difficulty of obtaining sufficient food gradually leads to emaciation. When a bougie is used, it generally passes into the diverticulum, and hence its onward course is arrested ; by careful manipulation it may be kept on the sound wall, and so slipped past the orifice into the stomach. Treatment, where possible, consists in exposing the diverticulum in the neck, removing it, and stitching up the opening in the pharyngeal or oesophageal wall, (b) Traction Diverticula are much rarer ; they usually occur on the anterior wall, near the bifurcation of the trachea, and are due to cicatricial traction from without, as by an inflamed bronchial gland. They are always of small size, often multiple, and cause no symptoms, unless a foreign body lodges in them, when ulceration and perforation may lead to suppurative mediastinitis and death. They cannot be recognised ante mortem. Foreign Bodies not unfrequently lodge in the oesophagus, especi- ally in children and lunatics. Portions of food, coins, fishbones, pins, plates of false teeth, etc., are the substances usually met with. The patient complains that something has lodged in the gullet, causing a feeling of pain and distension, whilst swallowing is painful or impossible, and respiration may be more or less hampered. Large bodies are often impacted at the entrance to the gullet, and then cause sudden death from dyspnoea ; if the obstruction is not so great and remains unrelieved, oedema of the glottis may supervene. Impaction lower down is likely to be followed by ulceration, perforation, and death, either from haemor- rhage owing to one of the large vessels being opened, or from suppurative cellulitis. In some cases, however (Konig states about 50 per cent.), the foreign body spontaneously passes either into the mouth or stomach. The Treatment varies much according to the nature, size, and situation of the obstructing body. If small and incapable of being detected by a sound — e.g., a fishbone — it is best removed by an expanding probang (Fig. 290), being caught in the loops of thick horsehair forming part of the apparatus. If a coin or small hard substance is impacted, it may be removed by oesophageal forceps, or by a coin-catcher. If it is impossible to draw it up, it may sometimes be pushed down into the stomach. A large bolus of food may be removed by forceps from the upper part of the oesophagus, and large foreign bodies— e.g., plates of teeth — may be similarly extracted, though great care must be taken not to tear the mucous membrane. Skiagraphy is now employed to AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS 807 assist in the localization of metallic substances such as coins, as also to determine whether or not they have been dislodged, whilst removal may be much expedited by the use of the cryptoscope. If impacted in the upper part, asophagotomy may be performed. An incision, 4 inches long, is made along the anterior border of the sterno-mastoid, preferably on the left side, because the oesophagus naturally curves that way. The platysma and deep fascia are divided, and the muscle drawn outwards ; the omo-hyoid needs division, and the surgeon then carefully works his way between the carotid sheath on the outer side, and the larynx and trachea on the inner, avoiding the thyroid vessels and nerves. The projection of the foreign body will indicate the situation of the tube, and this is carefully incised, and the obstruction dealt with. The oesophageal wound may then be closed by sutures which do not include the mucous membrane, whilst the external wound is either stuffed with gauze plugs or drained. When Fig. 290. — Expanding Probang for the Removal of Foreign Bodies from the cesophagus. located in the upper part of the thoracic portion of the oesophagus the tube is opened as low as possible by cutting down on the point of a bougie passed from the mouth, and then it is often possible to extricate it. When the foreign body is impacted near the cardiac orifice, and cannot be moved either up or down, the stomach may be opened, the fingers or even the hand inserted into it, the cardiac orifice dilated, and the obstruction removed. When once the foreign body has passed into the stomach, purgatives and emetics should be avoided, and if not of large size and irregular shape, the case is left to Nature, the treatment being merely expectant. The patient is kept quiet, and fed on pultaceous food — such as brown bread, porridge, etc. — and the motions are carefully examined. Should, however, the foreign body be large, and the gastric symptoms persist, it should be re- moved by gastrotomy. Inflammation of the oesophagus, with or without ulceration, is caused by swallowing corrosives or irritants, and, in a more localized form, by the impaction of foreign bodies. The symptoms are pain and difficulty in deglutition, and the treatment consists in the restriction of the diet to liquids, whilst in bad cases rectal feeding may be necessary. Chronic catarrh results from the SoS A MANUAL OF SURGERY continual drinking of raw spirits, and stenosis from cicatricial contraction may gradually follow. Varix of the veins in the lower portion of the oesophagus is occasionally met with as the result of pressure on the portal vein, or from cirrhosis of the liver. This is due to the fact that these branches open into the gastric division of the portal system, passing through the oesophageal opening in the diaphragm. Haematemesis may result, and has even proved fatal. Spasm of the (Esophagus, or hysterical stricture, arises in neurotic young women, usually under twenty-five years of age, and, although sometimes independent of organic lesion, is often associated with some slight abrasion or ulceration of the mucous membrane, perhaps originated by the impaction at an earlier date of a fishbone. The symptoms complained of are difficulty in swallowing, and a sensation as of a ball arising in the throat (globus hystericus), due to a spas- modic action of the pharyngeal constrictor muscles. At times, when the patient's attention is diverted, deglutition occurs quite normally. The best course of treatment is anti- neurotic in character (e.g., cold douches to the spine, massage, the administration of purga- tives, valerian, etc.), whilst the passage of a full-sized oeso- phageal bougie is useful. Organic Stricture of the (Eso- phagus occurs in two forms — - the fibrous and the malignant : i. Fibrous Stricture of the (Esophagus is usually located near its commencement, just behind the cricoid cartilage, and is most frequently caused by the swallowing of corrosives, and the cicatrization of the wounds caused thereby ; it also results from syphilitic disease. At the cardiac orifice it may arise from the healing and contraction of a gastric ulcer. The main symptom produced is a gradually increasing difficulty in the swal- lowing, firstly of solids, but finally even of fluids. If the obstruction is placed at the upper end of the tube, food is returned immediately ; but if lower down, the oesophagus may Fig. 291. — Cancerous Growth of the (Esophagus. (Treves' Sur- gery.) AFFECTIONS OF THE MOUTH, THROAT, AND OESOPHAGUS 809 become dilated, and in this pouch or cesophagocoele the food collects for a time, and then returns unchanged. There is but little pain in this form of stricture, although the patient is usually able to indicate the level of the obstruction. As the case pro- gresses, he becomes steadily emaciated from sheer starvation, and may even die from this cause. 2. Malignant Stricture of the Oesophagus is usually epithelio- matous in type, occurring in subjects over forty years of age, and situated either at the junction of the pharynx and oesophagus, i.e., behind the cricoid cartilage (Fig. 291), or in the middle of the tube, where it is crossed by the left bronchus or at the cardiac orifice of the stomach ; in the latter site, columnar carci- noma is the form usually found. The growth involves the whole circumference of the tube, and sooner or later ulcerates, perhaps perforating the trachea, pleural cavity, or one of the large vessels. Secondary deposits occur in the lymphatic glands, either of the neck or posterior mediastinum, visceral complications being uncommon. The symptoms are similar in character to those of fibrous stenosis detailed above, but in addition the vomited materials may contain blood, and there is a good deal of cough and pain, referred usually to the site of the disease. Should the growth be at the upper end of the tube, a tumour may be distinctly felt, placed deeply in the neck and more marked on the left side ; in the earlier stages nothing can be felt externally, although the side-to-side movements of the larynx may be im- peded. Perforation of the trachea leads to the entrance of food into the air passages, and rapidly results^in septic pneumonia and death. When the upper part of the gullet is affected, the growth may spread to the back of the larynx, and cause hoarseness and even aphonia. Occasionally the pneumogastric nerves may be involved in the mass, leading to interference with the action of the heart, whilst implication of the recurrent laryngeal nerve causes constant cough and uni- or bi-lateral paralysis of the larynx. The Diagnosis of oesophageal stricture must be made on general principles, and by a process of exclusion of the many other forms of dysphagia detailed below. It is confirmed by examining the con- dition of the tube with an oesophageal bougie. A conical-ended instrument of medium size should be employed for diagnostic purposes, and by this means the situation of the obstruction can be ascertained. To pass an oesophageal bougie : The surgeon stands in front and slightly to the right of the patient, who is seated with the head held forwards — if thrown backwards, the larynx is pressed against the spine, and the difficulty of introducing the instrument increased. The bougie is well warmed and smeared with glycerine, and, having been suitably curved, is guided by the surgeon's left index- finger over the epiglottis into the oesophagus. This stage usually causes a certain amount of discomfort and retching on the part of the patient. Once past the entrance to A MANUAL OF SURGERY the larynx, the bougie is pushed steadily onwards ; if there is no stricture, the instrument will enter the stomach about 16 inches from the teeth. If any obstruction is present, the large instru- ment is withdrawn, and the passage of a smaller one attempted. The greatest care must be taken, especially in suspected malignant disease, as it is by no means difficult to perforate the walls and open up the mediastinal tissues, even causing fatal cellulitis. A cancerous stricture sometimes feels rough and is painful ; a simple stricture is smooth, regular, and almost painless. It is by no means easy to distinguish the two forms, and the history of the case and general condition of the patient will need to be thoroughly investigated; a hacking cough with no special pulmonary symptoms is always a bad and suggestive sign. Treatment of Fibrous Stricture of the (Esophagus. — (a) Dilatation of the stricture by means of gradually increasing bougies ; for this purpose it is better to use conical-ended instruments rather than the usual type, which are of the same calibre throughout. An interval of some days should elapse between the attempts at dilatation, and during this period the patient should be given as much food as he can take in the shape of strong broths, minced meat, raw eggs, etc., or, if need be, rectal alimentation must be resorted to. (b) If it is impossible to dilate, or if the stricture recurs, a Symond's Tube may be inserted. It consists of a gum-elastic, funnel-shaped tube, passed through the stricture by a whalebone introducer, the funnel resting against the face of the stricture. A thread attached to the upper end is brought out of the mouth in order to remove and clean it, a proceeding needed about once a fortnight, (c) Internal cesophagotomy by means of a concealed knife has also been attempted, the stricture being divided posteriorly ; it is a somewhat risky proceeding, and is only feasible when the lesion is situated high up in the tube, (d) When the contraction is at the pharyngeal extremity, it may be possible to open the oesophagus below, and either divide and dilate the stenosed portion, or ecsophagostomy may be performed by sewing the mucous membrane to the skin, thus forming an entrance to the alimentary canal in the neck. Under these circum- stances, it is better practice to completely divide the oesophagus, closing the upper end by sutures, and fixing the lower end to the margin of the wound, (e) If the cardiac orifice of the stomach is contracted, the stomach may be opened as in gastrotomy, and the fingers used to dilate the stricture (retrograde dilata- tion), a proceeding similar to Loreta's operation for stricture of the pylorus. (/) Where none of these proceedings are possible, or if tried have failed, the stomach may be opened, and division of the sticture by Abbe's string saw attempted. The patient is made to swallow one end of a piece of string, or a small shot may be clamped on a piece of fine silk, and allowed to find its way into the stomach. When this viscus is opened, the free end AFFECTIONS OF THE MOUTH, THROAT, AND CESOPHAGUS Sn is secured, and by its means a coarse silk thread is carried through the obstruction ; by up-and-down sawing movements the stricture can be thereby divided, enabling the surgeon to introduce bougies. Excellent results have been reported from such practice. (g) Gastrostomy is the final resource ; occasionally, when the oesophagus has by this means been kept at rest for some time, the stricture will yield, and dilatation by bougies becomes prac- ticable. In such a case the opening in the stomach may be allowed to close. Treatment of Malignant Disease of the (Esophagus. — Dilatation by bougies should not be employed as a routine practice, for fear of increasing the ulceration, causing severe haemorrhage, or per- forating the walls of the tube. It may, however, be used as a temporary measure in the earlier stages to enable the patient to take an increased amount of food, and thus for a time improve his general condition and render him more fitted to undergo further treatment. Symonds' method of tubage may be utilized in malig- nant disease, the patients often bearing the inserted tube well, even when the cardiac orifice is involved, the lower end then projecting into the cavity of the stomach. Unfortunately these tubes occa- sionally slip through into the stomach, or the guiding string is swallowed ; moreover, under the best circumstances the tube needs changing every fortnight, and the ulceration may be increased thereby. Hence gastrostomy, performed as soon as possible by one of the modern methods, is a much more satisfactory plan of treat- ment. Excision of the growth in the neck has been successfully accomplished in a few cases when the disease was recognised early, and very limited in extent. Tracheotomy is occasionally required in the later stages, from implication of the glottis or trachea. By the term Dysphagia is meant a condition in which swallowing is painful or difficult. The Causes are very numerous, and may be arranged as follows : i. Pharyngeal — e.g., acute or chronic inflammation, whether simple, scarlatinal, diphtheritic, etc. ; ulceration of syphilitic or malignant origin ; stenosis, as a result of ulceration ; paralysis (eg., labio-glosso-laryngeal or bulbar) or spasm ; impaction of foreign bodies ; naso-pharyngeal polypi projecting behind the velum ; retro-pharyngeal abscess or tumour, etc. ii. Laryngeal — eg., acute or chronic laryngitis; tuberculous, syphilitic, or malignant disease. iii. (Esophageal —e.g., acute or chronic inflammation, impaction of foreign bodies, the presence of diverticula, cesophagospasm, and simple or malignant stricture. iv. Extrinsic. In the neck : goitie, enlarged glands, aneurisms, etc. ; in the thorax : mediastinal growths or glands, aneurisms of the aorta and large vessels, tumours growing from the vertebral bodies, pericardial effusion, and displace- ment backwards of the sternal end of the clavicle. To investigate a ease of dysphagia, note : (i.) the method of onset, whether acute or chronic — if the former, it is probably due to a foreign body ; (ii.) the condition of the pharynx as seen from the mouth and on digital exploration ; (iii.) the condition of the neck as seen and felt from without, whether or not a tumour is to be felt behind the cricoid, or whether a goitre or aneurism exists ; (iv. ) the character of the voice, as indicative or not of larvngeal mischief — if the voice 812 A MANUAL OF SURGERY is husky, a laryngoscopic examination must be made; (v.) the chest must be carefully examined for aneurisms, etc. ; (vi.) the oesophagus may be auscultated along the vertebral groove whilst the patient drinks water to ascertain the situation of the mischief; (vii.) it must be examined finally by bougies. If the obstruction is in the oesophagus, the patient's age and general condition will give prima facie evidence as to whether or not it is due to malignant disease; but it must not be forgotton that the stenosis per se causes some of the loss of flesh and of weight. The presence of blood and offensive mucus on the bougie or in the material vomited, and the existence of enlarged glands in the neck, will also assist in establishing a diagnosis. CHAPTER XXVIII. AFFECTIONS OF THE EAR. It is impossible to do more than deal with some of the more important surgical aspects of diseases of the ear in this place, and for a more detailed consideration of the subject we must refer our readers to special text-books. The External Ear is the site of various affections which may come under the observation of the general surgeon. Thus, the pinna may be congenitally absent, and even the external meatus closed, a malformation often associated with macrostoma. Nothing can be done for this want of development, and the surgeon must never be tempted to try and dig out the concealed membrana tympani. More frequently accessory auricles are pre- sent, consisting merely of fibro-cartilage covered with fat and skin. Large and prominent ears constitute a very unsightly deformity, for which operative interference is occasionally required. The size may be diminished by removing a V-shaped portion from the upper part ; the prominence, by excising a portion of skin and cartilage through an incision on the posterior aspect. The wounds thus produced are accurately sutured together, and considerable improvement in the appearance results. Haematoma of the ear is usually due to injury, but is occasionally idiopathic in origin, especially amongst the insane. The auricle becomes swollen and enlarged, and of a bluish-red colour in traumatic cases (Fig. 292) ; unless inflamed it should not be interfered with, as a general rule, although, if the appearance of the patient is important, it may be advisable to remove the blood, since its organization and subsequent contraction may lead to considerable deformity. Eczema, boils, and other inflammatory affections, are met with in the external ear and pinna, but these call for no special mention. Plugs of wax (cerumen), which become dark and indurated, not unfrequently block the meatus, leading to more or less complete deafness ; this may come on suddenly after bathing, owing to the plug rapidly swelling up. If they encroach on the membrana tympani, subjective symptoms of giddiness, vomiting, and rushing noises in the ear may also be caused. On examination with an 8i 4 A MAN (LI I, OF SURGERY Fig. 292. — Hematoma Auris. ear speculum, their presence is readily detected. Treatment con- sists in washing them away, after previously softening with oil or glycerine. A large syringe with a fine nozzle should be used, and a stream of warm water injected along the roof of the meatus ; as it returns, the softened masses of wax are washed away. Foreign bodies in the meatus, such as buttons or beads, are similarly removed, if possible, by syringing ; if this fails, a fine pair of forceps is employed for the purpose, but it must be remembered that behind the foreign body lie delicate structures, which can readily be harmed by the exhibition of im- patience or force. Where all other plans fail, the auricle may be turned forwards and the meatus opened from behind. Exostoses are occasionally met with springing from the bony walls of the meatus; they give rise to deafness by obstructing the passage, and may be removed by the dental drill. The Surgical Complications of Chronic Otorrhcea are frequently serious, and call for prompt treatment. The discharge usually comes from the middle ear (otitis media) through a perforation in the tympanic membrane. It must be noted that the tympanic cavity is lined by a mucous membrane which is in direct communi- cation through the Eustachian tube with that lining the nasal fossae ; and since this membrane is adherent to the periosteal lining of the cavity, every case of otitis media is likely to be associated with an internal periostitis of the temporal bone. These complications may be classified under three main headings — the extracranial, the cranial, and the intracranial. The extracranial complications of otorrhcea are comparatively unimportant. (a) Eczema of the meatus is frequently seen, and merely needs the parts to be kept dry and clean, and possibly a little boric acid powder insufflated ; it readily disappears when the discharge ceases, but is not unfrequently associated with enlargement of the cervical glands, which may suppurate, or in predisposed indi- viduals may become the seat of tuberculous disease. (b) Boils arise from infection of the sebaceous glands in the meatus with pyogenic cocci from the discharge, and are exceed- ingly painful owing to the denseness of the tissues involved. They should be fomented, and opened when pus has formed. AFFECTIONS OF THE EAR Si (c) Inflammation may occasionally spread from the meatus to the tympanic plate of the temporal bone, leading to subperios- teal abscess and necrosis ; or it may extend into the temporo- maxillary articulation, giving rise to suppurative arthritis and disorganization of that joint (p. 750). The cranial complications of otitis media are often of a grave nature, and may end in permanent deafness, or even endanger the life of the individual. (a) The ossicles frequently necrose, and are cast off in the discharge, and thus hearing may be impaired, although not necessarily destroyed ; ankylosis of the ossicles one to another may also be determined, leading to considerable loss of function. (b) The inflammation may extend from the lining membrane of the tympanum to the bony walls surrounding it, giving rise to a limited caries or necrosis of the temporal bone. This may be associated with suppuration within the skull, and any of the intracranial complications mentioned below. The roof of the tympanic cavity (tegmen tympani), which is very thin, is especially liable to be affected in this way. If diseased bone can be felt through the external auditory meatus with a probe, an attempt should be made to remove it ; if this is impossible, the part must be kept clean by the injection of mild antiseptics, retention of discharges being prevented by the regular use of Politzer's bag. (r) Polypi may also develop, consisting essentially of granulation tissue protruding through the opening in the membrane ; they lead to considerable obstruction, and may do harm by keeping back the discharge. They should be removed by the curette, and the bare bone, usually felt at their base, scraped ; the part is subsequently syringed with a weak carbolic solution and dressed antiseptically. (d) Facial paralysis not uncommonly arises from sclerosis and thickening of the bony tissue surrounding the aqueductus Fallopii, causing pressure on the nerve in that region. It must be remembered that the bony canal lies immediately behind the tympanic cavity, and to the inner side of the passage from the attic to the mastoid antrum (iter ad antrum). All the muscles on that side of the face are involved, and possibly also the palate and uvula. No radical treatment is practicable, although the face should be regularly faradized, so as to maintain as far as possible the tone of the muscles. (e) Inflammation may also extend into the mastoid cells, giving rise to the condition known as mastoiditis. The mastoid process is a triangular mass of bone, which is practically undeveloped until the age of puberty. Before that period a single cell rela- tively of large size communicates with the posterior portion of the tympanic cavity and represents the antrum ; but after puberty the whole bone becomes hollowed out into a series of spongy 8i6 A MANUAL OF SURGERY cells, lined with mucous membrane, which open into the floor of the antrum. When the inflammation in otitis media, which has almost always become septic, extends into this bony process, severe local and general symptoms are likely to result. The patient complains of intense pain in the ear, with tenderness on pressure, and perhaps redness and oedema over the mastoid process. The discharge from the ear often ceases for a time at the commencement of these symptoms, but reappears later on. As the case progresses, febrile symptoms of an intermittent type, and even rigors, may supervene, whilst the patient becomes drowsy, or may be irritable and restless. An abscess may form under the periosteum covering the mastoid process, with or without caries or necrosis of the outer table of the bone ; in children, where this bony lamella is thin, it is not unfrequently absorbed, and on incising the abscess protuberant masses of granulations, springing from the interior of the bone, may be seen. When an abscess has developed, the auricle is characteristically displaced downwards and outwards. Any of the intracranial complications mentioned below may occur as sequelae. Occa- sionally the mastoid trouble is of a more chronic type, and even tuberculous in nature, the cells being choked up with lymph and inflammatory material of a cheesy nature, whilst the bone itself becomes thickened and condensed. The process feels distinctly enlarged, and a good deal of deep-seated pain of an aching character is experienced, and worse at night. When the discharge is inspissated and mixed with epithelial cells and cholesterine, so as to form flaky masses like the layers of an onion, the condition is known as cholesteatoma. It is often the cause of great distension of the antrum, which in a case operated on by one of us measured quite i| inches across. The symptoms, at first of a chronic type, are likely to be followed sooner or later by an acute attack of septic inflammation. Treatment. — In the early acute stage belladonna fomentations may be employed, and the patient kept quietly in bed, whilst the diet is regulated and a suitable purgative administered ; accu- mulated discharge is removed from the tympanum by the use of Politzer's bag. Two or three leeches may also be applied over the mastoid process, and relief to the pain thus obtained, though it is often only of a temporary character. It is most important not to rely upon such palliative measures for too long, but when the symptoms are well marked, even in the early stages, and before suppuration has occurred, it is good practice to make an incision (Wilde's incision) down to the bone, reaching from the base to the apex of the process ; much relief is always obtained by this procedure, and the inflammatory phenomena are some- times completely checked. Should this not succeed, the mastoid antrum must be laid open and its contents evacuated (Schwartze's operation). Many instruments have been suggested in order to AFFECTIONS OF THE EAR Si 7 accomplish this ; thus, it has been recommended to use the brad- awl, trephine, gouge, or gimlet ; the gouge is, however, probably the best, if a burr worked by a surgical engine is not obtainable. A curved incision is made immediately behind the ear, which is drawn well forwards (Fig. 293), and the gouge applied on a level with the roof of the external auditory meatus, and about -| inch behind its centre (Fig. 294). A small dimple in the bone can often be felt at the required spot, which can also be found by taking the point of junction of two lines drawn as tangents to the roof and posterior wall of the bony meatus respectively (Fig. 295, C). The direction taken by the gouge should be slightly downwards, forwards, and inwards, and a useful guide will be found in a probe passed down the external auditory meatus, the boring being made exactly parallel to this. In an t'-^^ja^ Fig. 293. — Incision for Mastoid Fig. 294 .—Site for Drilling Bone Operations. in order to open the Mastoid Antrum. It is often well to apply the chisel as indicated here so as to include a triangle, the centre of which corresponds to the apex of the so-called supra-meatal triangle. As soon as the outer layers of the bone have been removed by the chisel, the gouge is used to reach the deeper parts. adult the mastoid antrum is reached about three-fifths of an inch from the surface of the bone. The surgeon recognizes that he has opened the cavity by the loss of resistance, and the escape of exceedingly offensive pus. The opening is then freely enlarged by the use of the gouge and cutting pliers, and the cavity syringed out through the external meatus. Diseased bone in the mastoid process or around the tympanic cavity may be scraped away, and the wound plugged with antiseptic gauze ; it should be syringed through from the external meatus daily. In the more chronic cases it may be advisable to split off the whole of the outer coating of bone from the mastoid process, so as to lay open all the cells, which will often be found filled with inspissated pus. In the more severe forms it is recommended to detach the auricle posteriorly from the bony margins of the meatus, and then to gouge away the whole of the osseous tissue intervening 52 8i8 A MANUAL OF SURGERY between the meatus and tympanic cavity in front and the mastoid antrum behind. A metal guide is passed from the opening in the antrum into the attic along the iter, and all the bone in front of the guide may be safely removed. The facial nerve and superior semicircular canal lie behind, and are protected by the guide. The remains of the membrane and the ossicles are then removed, and the whole cavity well curetted. The deep portion of the posterior wall of the cartilaginous meatus is incised longitudinally and the margins of the aperture stitched to the posterior edge of the wound, the meatus thus leading to the whole of the opening in the bone, which can in this way be syringed out and cleaned more efficiently (Stacke's operation). The results of this proceeding have been very satisfactory, but the proximity of the facial nerve must never be forgotten, and the anaesthetist should be instructed to watch the face continuously for any twitching, which indicates that the nerve is being touched, inasmuch as the surgeon is working at the side, and cannot see. The intracranial complications of otorrhcea are subcranial abscess, localized or diffuse meningitis, thrombosis of the lateral sinus, and abscess in the cerebrum or cerebellum. (a) Subcranial Abscess. — When the roof of the tympanum or any part of the lining of that cavity which encroaches on the cranium becomes inflamed or carious, suppuration between the skull and dura mater may ensue. The membranes are gradually stripped from the bone by the increasing pressure of the exuda- tion, and symptoms of cerebral compression and irritation are thereby induced. Accumulations of pus occur most commonly along the summit of the petrous portion of the temporal bone, and in the sulcus in which the lateral sinus is lodged. The patient complains of pain and headache, which increase for a time and are then followed by drowsiness, which may pass into coma. The temperature is usually raised, but rigors, even if present at first, are by no means a constant feature of the case. The pulse is of the usual febrile type, viz., full and bounding. There is no pain in the neck along the course of the jugular vein, but retraction of the head occurs if basal meningitis is present, and vomiting is a marked symptom. Optic neuritis may be observed in consequence of the inflammation extending to the membranes at the base of the brain. There may be some tender- ness on pressure over the temporal region, and even possibly oedema. In some cases the pus finds its way outwards along the mastoid emissary vein, or through the suture between the occipital and temporal bones (See also p. 690.) The Diagnosis from cerebral abscess is sometimes a matter of considerable difficulty. The symptoms, however, set in some- what more acutely, whilst the temperature is raised, and the signs of irritation of the membranes, such as retraction of the neck, all •• .„• ,:2 V" v -j o s~**, c-a-^^^j § £ vates, the soft palate. A beam • ■ of light is thrown into the • \- • ; mouth, either from an electric ( .. \ head - lamp on the surgeon's \ forehead, or reflected by a frontal mirror from a suitable source of illumination. The " patient's tongue, held with a towel, is drawn well forwards so as to enable the light to reach the larynx, the image of which "J is seen in the mirror. Con- siderable practice is needed in order to attain any facility in the use of this instrument, as also to be able to recognise normal from abnormal struc- tures. The use -of cocaine to anaesthetize the fauces is in many cases indispensable. It must be remembered that the image is always inverted, so that the anterior portion of the larynx appears behind, but there is no reversal of the sides. Acute and Chronic Laryngitis are conditions of but slight surgical interest. The acute affection arises from cold or over-exertion of the vocal ap- paratus, and is characterized by aphonia (loss of voice) and cough. Locally, the vocal cords ({■>» Fig. 301. — CEdema of Glottis and Tongue from Behind. (College of Surgeons' Museum.) are seen to be hyperaemic and The tongue is seen to be enlarged and swollen, swollen. The Treatment is rather and the aryteno-epiglottidean folds are medical than surgical, although cedematous, so that the entrance to the in children intubation or trache- larynx is represented by a mere chink, otomy may be sometimes re- quired. Diphtheritic Inflammation of the Larynx is usually met with as an extension of a similar affection of the fauces. It gives rise to severe dyspnoea from obstruction in the rima glottidis, and, if the condition does not yield to the injection of the diphtheritic antitoxin, will probably require intubation or tracheotomy. 842 A MANUAL OF SURGERY Acute (Edematous Laryngitis, or oedema of the glottis, is a condition of con- siderable surgical importance. Causes. — (a) It is either secondary to some other laryngeal affection, such as acute catarrhal laryngitis, or acute peri- chondritis ; or (b) may extend from inflammatory conditions of neighbouring tissues, such as the root of the tongue, or the submaxillary region, e.g., in cellulitis or Ludwig's angina ; or it may be secondary to a retropharyngeal abscess. (c) It is also not un frequently seen in children from drinking scalding water, as from the spout of a kettle, or sometimes in adults from swallowing corrosives, (d) It may result from the presence of a foreign body. Characters. — The folds cf mucous membrane extending on either side of the epiglottis both to the root of the tongue and backwards to the arytenoid car- tilages become swollen and cedematous from a serous infusion into the sub- mucous tissue (Fig. 301). The same condition also involves the inter-arytenoid fold and the false vocal cords (superior thyro-arytenoid folds), extending down as far as the true cords. The process, is checked at this level owing to the absence of submucous tissue, the vocal cords consisting of elastic fibres, merely covered with a layer or two of squamous epithelium. The epiglottis becomes folded laterally upon itself as a leaf, merely leaving a valve-like chink which permits of expiration, although considerably checking inspiration. The Symptoms produced by this condition are those of mechanical dyspnoea, to which, not unfrequently, spasm of the glottis is superadded, and this is sometimes of sufficient intensity to destroy the patient's life. There may be also some amount of febrile disturbance. The diagnosis is made, either by passing the finger into the pharynx, when the rigid swollen epiglottis can be felt, or by laryngoscopic examination, when the slit-like opening of the glottis, bounded below and behind by thickened cedematous folds of mucous membrane, can be seen. Treatment consists in scarification of the swollen tissues below and behind the epiglottis, which can be effected, after spraying the parts with cocaine, either by the finger-nail or with a suitable knife guided by a laryngoscope. The usual result is a rapid diminution of the oedema, and additional relief may be gained by inhaling steam arising from hot water, to which some tinct. benzoini co. has been added. Fomentations or ice com- presses applied externally are also useful, especially the latter. In more severe cases, and especially in children, intubation may be necessary, or the air- passages may be opened below the obstruction, laryngotomy sufficing in adults, but a high tracheotomy being needed in children. Syphilitic Disease of the Larynx. — In the secondary stage, mucous tubercles or superficial ulcers occasionally form in the neighbourhood of the vocal cords, concurrently with the rash on the skin, and the formation of condylomata and mucous tubercles elsewhere. It is very likely to occur in costermongers or those who have to speak loudly, and may then lead to a good deal of thickening of the cords. Apart from such cases, it rarely causes much trouble beyond a little hoarseness. No special treatment is required, although possibly the parts, if ulcerated, may be brushed over with a solution of perchloride of mercury. In the tertiary period, diffuse gummatous infiltration or localized gummata may develop, giving rise to destructive ulceration, which especially affects the epiglottis and aryteno-epiglottidean folds, and may spread back- wards and involve the whole glottis (Fig. 302). Inflammation of the peri- chondrium is likely to follow, leading to necrosis of the cartilages. Hoarseness and dyspnoea are the chief symptoms of this affection, whilst considerable obstruction may be subsequently caused by cicatrization and laryngeal stenosis. Treatment consists in the administration of iodide of potassium and mercury, whilst ulcers may be sprayed with perchloride of mercury solution, or dusted over with calomel or iodoform. Should urgent dyspnoea, arise, tracheotomy must be undertaken. Tuberculous Laryngitis (Fig. 303) is occasionally a primary manifestation, but is much more frequently secondary to phthisis, arising from infection of the mucous membrane owing to the constant passage over it of the sputum. It usually commences at the posterior part of the larynx in tha SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST 843 neighbourhood of the arytenoid cartilages, as a submucous infiltration, which breaks down, and leads to typical tuberculous ulcers, similar to those occurring in other viscera (p. 359). Considerable destruction of tissue ensues, involving the whole circumference of the larynx, and even leading to necrosis and destruction of the cartilages. Hoarseness, cough, and perhaps a certain amount of dyspnoea, in a patient suffering from phthisis, are the chief symp- toms arising from this affection, the prognosis of which is always of a grave nature. Treatment .—In phthisical patients local treatment is of but little avail, but where the disease is primary an attempt should be made to deal with it ; such, however, can only be undertaken by the skilled laryngologist, as it consists in the topical application of caustics and antiseptics. Thyrotomy or subhyoid pharyngotomy has sometimes been practised, in order to attain this object more thoroughly. Paralysis of the Larynx is observed in a variety of conditions, but is only of surgical interest when arising from injury or division of, or pressure upon, the recurrent laryngeal nerve. It may follow the removal of a goitrous tumour or of tuberculous glands, but is most commonly seen in connection with aneurisms of the innominate or aorta, or tumours in the same neighbourhood, e.g., cancer of the oesophagus, the factual "pressure in the latter case being Fig. 302. — Gummatous Disease of the Larynx. (Tillmanns.) Small gummata are seen invading the mucous membrane of the epiglottis and front of the larynx. Fig. 303. — Tuberculous Disease of the Larynx, with Extensive Ulceration in Front and Behind. (Tillmanns.) a, b, c, Remains of the epiglottis. probably exercised by secondarily enlarged lymphatic glands. Paralysis from the above causes is generally unilateral, but if due to cancer both sides may be involved. The effect of complete paralysis of one recurrent laryngeal is to produce total immobility on the affected side of the vocal cord, which lies in what is known as the ' cadaveric position' — i.e., midway between that in which it is placed during phonation and during inspiration. Not uncommonly the paralysis is incomplete, and then merely affects the abductor muscle (the crico-arytenoideus posticus). The Symptoms arising from unilateral recurrent paralysis are often slight, the voice being usually but little modified, owing to the healthy cord being capable of passing across the middle line. If, however, both sides are completely paralyzed, absolute aphonia, without dyspnoea, results ; but if only the abductors are involved, the voice may be unimpaired, although severe dyspnoea is often present, and this may prove fatal unless tracheotomy is promptly performed. Papilloma of the Larynx (Fig. 304) occurs in the form of wart-like masses, usually growing from the true vocal cords, and giving rise to considerable hoarseness and perhaps some dyspnoea. They are recognised on laryngo- scopy examination, and may be removed successfully by laryngeal forceps, after the parts have been efficiently cocainized. It is recommended by some authorities to destroy the growth with a galvano-cautery. Epithelioma Laryngis occurs in patients over forty, originating as a papillary overgrowth, usually near the base of the epiglottis, or from the true or false cords (Fig. 305). The tumour gradually spreads, both superficially and deeply, 844 A MANUAL OF SURGERY and may invade the cartilages, giving rise to necrosis. At a later stage it extends beyond the limits of the larynx, attacking the base of the tongue, oesophagus, and even the lateral walls of the pharynx. As long as the disease is strictly limited to the larynx (intrinsic), the growth is often unilateral, causing hoarseness and aphonia, together with an irritable cough and the expectoration of blood-stained muco-pus, which may be horribly offensive ; it is associated with but little tendency to affection of lymphatic glands. When, however, the growth has extended to surrounding structures (extrinsic), lymphatic enlargement follows, and the disease runs its usual course, destroy- ing life by dyspnoea and exhaustion. Pain is often a most distressing symptom, being referred either to the larynx or pharynx, or, according to Ziemssen, not unfrequently to the ear. Treatment. — In the early stages it is possible that thyrotomy and efficient curetting and cauterization may suffice to bring about a cure. Later on, removal of one or both halves of the larynx will be required, and the operation may even include parts of the tongue and Fig. 304. — Papillomata of the Larynx, springing from the Right Vocal Cord. (Till- MANNS.) Fig. 305. — Epithelioma of the Larynx, involving the Right Vocal Cord and Base of the Epiglottis. (Till- MANNS.) pharyngeal wall. Where, however, the disease has spread extensively, its total extirpation is rarely practicable, and all that can be done is to treat symptoms as they arise, and perform tracheotomy when necessary. Operations upon the Air-passages. 1 . Subhyoid Pharyngotomy was devised by Malgaigne, in order to provide access to the upper parts of the larynx in the treat- ment of foreign bodies or tuberculous disease. A transverse incision is made through the thyro-hyoid space, the pharynx is opened, and the epiglottis detached from the base of the tongue (Fig. 306, I.). It is a proceeding that is seldom undertaken, and scarcely necessary. A much more satisfactory procedure is Trans-hyoid Pharyn- gotomy,^ in which the hyoid bone is divided in the middle line through a vertical incision extending from the symphysis menti to the thyroid cartilage. The pharynx can then be opened either above or below the level of the hyoid bone, and the back of the tongue, the posterior wall of the pharynx, or the upper part of the larynx freely exposed. A preliminary tracheotomy is of course necessary. We have utilised * See Revue de Chirurgie, May, 1900. SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST 845 this operation both for the removal of an epithelioma of the epi- glottis and back of the tongue, and for enucleating a sarcoma of the posterior pharyngeal wall, and were much pleased with the approach given to these parts. 2. Thyrotomy (Fig. 306, II.) consists in a partial or complete vertical section of the thyroid cartilage, and may be required for the removal of foreign bodies or tumours, or for the radical treatment of laryngeal tuberculosis or cancer. Tracheotomy is performed as a pre- liminary measure, and the trachea plugged around the tube. An in- A.. J\ \ II 111 %Zi Sch H Th Th cision is then made in the middle line of the neck, extending from the hyoid bone to the cricoid cartilage. The crico-thyroid ligament is clearly de- fined and severed transversely, and the thyroid cartilage accurately divided by a knife, cutting-pliers, or fine saw. The lateral halves are separated, and the intra-laryngeal portion of the operation proceeded with. When closing the wound, the greatest care must be taken to bring the sides together in such a way that the vocal cords are exactly opposite each other, or phonation will be considerably impaired. This is best ensured by making a hori- zontal cut across the front of the cartilage before dividing it. 3. Extirpation of the Larynx (Laryngectomy) is always a serious operation, which is never under- taken except for malignant disease. According to the site of the tumour the removal may be partial or com- plete ; for a growth strictly limited to one side, extirpation of that half will suffice, and admirable re- sults have followed such treatment, distinct speech remaining ; but if the whole larynx is removed, although the patient is subsequently able to whisper, phonation is impossible without mechanical assist- ance, whilst if the disease has extended beyond the limits of the larynx, operative interference is very unsatisfactory. Operation for Complete Extirpation. — A low tracheotomy should be performed, as a preliminary measure, and preferably a few days before ; the trachea is plugged with a Halm's tube or a Trendelen- burg's air tampon at the commencement of the operation. An V \1 Fig. 306. — Operations on the Air-passages. (Tilmanns.) I., Subhyoid pharyngotomy ; II., thyrotomy: III., laryngotomy ; IV.,cricotomy; V., high trache- otomy ; VI., low tracheotomy ; Z, hyoid bone; Sch, thyroid cartilage ; R, cricoid ; Th, thyroid body. 846 A MANUAL OF SURGERY incision is made in the middle line of the neck from the hyoid bone to below the cricoid cartilage, at the upper end of which a transverse cut is made, extending as far as the sterno-mastoid muscle on either side. The soft parts are then stripped from the lateral borders of the thyroid cartilage with raspatories, the sterno- hyoid, sterno-thyroid, and thyro-hyoid muscles being divided at their insertions. Both the superior and inferior laryngeal vessels are tied and divided. Having thus freed the larynx anteriorly, the subsequent steps of the operation may be undertaken either from below upwards or from above downwards ; the former pro- ceeding is, to our minds, the better. The crico-tracheal mem- brane is divided, and the larynx drawn forwards, so as to enable the posterior attachments, i.e., the connections of the constrictor muscles to the cricoid and thyroid cartilages, to be severed by scissors, the larynx being thus separated from the anterior pharyngeal wall, which must be left intact, if possible. The thyro- hyoid membrane and the base of the epiglottis are cut through, and the final steps of the operation consist in clearing the superior cornua of the thyroid, and dividing the lateral thyro- hyoid ligaments. The operation is not particularly difficult or dangerous, provided that the surgeon keeps close to the larynx, and that the disease does not spread beyond its limits. When other structures, such as the base of the tongue, have been invaded by the growth, these steps must be modified so as to secure, if possible, complete removal of the disease. Finally, the transverse incision is sutured, but no stitches are inserted in the median wound, which is plugged, and allowed to heal by granula- tion. The upper end of the trachea should be secured to the skin at the lower angle of the wound, so as to prevent its retraction. The patient is fed per rectum for a few days, or by the passage of an oesophageal tube. At the end of a week the tracheotomy tube is removed from its original situation, and inserted into the upper end of the trachea, the lower opening being allowed to close. When the wound has healed sufficiently, an artificial larynx can be inserted, by means of which the patient is able to speak in a somewhat reedy monotone, but it is seldom satisfactory. Dr. H. Lambert Lack advocates the total closure of all com- munication between the pharynx and the air-passages after laryngectomy. The upper end of the trachea is securely stitched all round in the lower angle of the incision and flush with the surface. The rent in the mucous membrane of the pharynx is then carefully closed ; the wound is thoroughly disinfected, and the various layers of muscles are sutured together, as also the skin. Union by first intention can thus be attained, and the results have been most gratifying. Phonation is of course lost absolutely, but the patient can whisper, the necessary air-pressure being obtained in the dilated pharynx or upper end of the oesophagus. SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST 847 If the disease is limited to one half of the larynx, the thyroid cartilage is cleft in the middle line, and the operation confined to the affected side. 4. Laryngotomy is always undertaken for the relief of dysp- noea arising from some sudden obstruction to the respiration, and is thus to be looked on as an operation of urgency. It is required in cases where the entrance to the larynx is obstructed by a foreign body, for spasm of the glottis, or for accumulations of blood in the neighbourhood of the larynx during an operation. It is readily performed by making a vertical incision over the situation of the crico-thyroid membrane, which is then divided transversely along the upper border of the cricoid cartilage, the sterno hyoid muscles being, if necessary, drawn aside, and a tube inserted. Possibly the small crico-thyroid artery arising from the superior thyroid may require a ligature. In cases of great urgency, a simple transverse incision may be made with a pen- knife, and the larynx opened, the margins of the wound being held aside by a hairpin, or by the handle of a scalpel turned edge- ways, whilst a toothpick will serve temporarily as a cannula. Whenever there is time to operate deliberately, a high tracheotomy is the better practice, since a tube inserted through the crico- thyroid space gives rise to considerable irritation, and the voice may be subsequently impaired by the contraction of the cicatrix. A special laryngotomy tube is required, the lumen of which is oval and flattened from above downwards, not circular. In children, where there is but little space, the proceeding may be modified by division of the cricoid cartilage, and even of the first ring of the trachea, constituting what is known as cricotomy, or lavyngotvacheotomy (Fig. 306, IV.). 5. Tracheotomy. — The trachea usually consists of from sixteen to twenty rings, of which six or seven are situated above the sternum. The isthmus of the thyroid body usually covers the third and fourth rings, and the trachea may be opened either above or below it, or even sometimes behind, the isthmus being, if necessary, divided. Tracheotomy is required in any condition in which there is serious obstruction to the respiration, e.g., various forms of laryngitis, and especially that due to diphtheria ; for stenosis, tumours, and some forms of paralysis of the larynx ; for the removal of foreign bodies, either in the larynx, trachea, or one of the bronchi; or for compression of the larynx or trachea by external tumours, such as an enlarged thyroid body. It is also undertaken as a preliminary measure in operations on the mouth, tongue, pharynx, or larynx, in which there is any likeli- hood of asphyxia or secondary septic pneumonia, owing to the entrance of blood or septic discharges into the air-passages. As a general rule, the high operation (that is, above the isthmus of the thyroid body) is to be preferred, but under special circum- stances it may be advisable to open the trachea lower down. 8 4 S A MANUAL OF SURGERY The risk attaching to the high operation is considerably less than to the low, but the opening is made nearer to any disease which may exist in the larynx. For the removal of foreign bodies from the bronchi or trachea, the low operation should always be employed. The high operation (Fig. 306, V.) is performed as follows : The patient is placed on the back, with a sandbag or pillow beneath the neck, so as to throw the head backwards and put the struc- tures on the stretch, and with the shoulders somewhat raised. Anaesthesia may be induced by chloroform, but it is unnecessary, and indeed unwise, to push the anaesthetic, since it is only needed for the division of the skin ; where the dyspnoea is considerable, it is better to employ cocaine. The head is held exactly in the middle line, and the surgeon feels for, and identifies, the cricoid cartilage. The incision extends from this structure downwards for about 1^ inches. The superficial fascia is divided, and the interval between the sterno-hyoid muscles made out, so as to Fig. 307. — Durham's Tracheotomy-tube. (Down Brothers. A, Outer-tube with introducer; B, lobster-tailed inner-tube. enable them to be separated one from the other. The edges of the wound are drawn aside by blunt hooks, which should both be held by one assistant, so as to ensure equable traction. The isthmus of the thyroid body may now be seen, and, if pro- jecting unduly upwards, should be pushed down after the fascia along its upper border has been transversely incised. The trachea is next clearly exposed by using the handle of a scalpel and dis- secting forceps, and should be fixed and steadied by inserting a sharp hook into the lower border of the cricoid cartilage. The wound is freed from blood as far as possible, and the trachea opened by inserting the point of the scalpel and dividing two of the rings from below upwards. A deep inspiration is usually taken at once, followed by a severe fit of coughing, and if the operation is undertaken for diphtheria the surgeon must be careful not to let any membrane which may then be expelled enter his eyes, nose, or mouth. The insertion of the tube is in many cases easy, in SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST 849 others a matter of some difficulty ; a good deal depends upon the age of the patient, the urgency of the symptoms, and the depth from the surface at which the trachea lies. Anything which suffices to separate the lips of the tracheal incision, e.g., the handle of a scalpel introduced and turned, a couple of hooks, or dressing forceps, will form an efficient guide for this purpose. The breath- ing soon becomes quiet and regular, and the tube is fixed in position by tapes passed through lateral openings in the face-plate, and tied round the neck. No dressing is required for the wound except a few layers of gauze beneath the plate. Low tracheotomy (Fig. 306, VI.) is performed in almost precisely the same way, except that the in- cision extends farther downwards, even reaching to the episternal notch, although the deeper part of the wound should never pass be- yond a finger's breadth above the sternum, for fear of opening that portion of the cervical fascia which is prolonged downwards to the pericardium, or of wound- ing the left innominate vein. The superficial layers of fascia are divided, and the sterno-hyoid and sterno-thyroid muscles drawn to either side by retractors. The inferior thyroid veins then come into view, and may cause trouble if they are distended with blood , as is so frequently the case in patients suffering from dyspncea. They must be held aside by hooks, or divided between liga- tures, and the deep layer of fascia behind them incised so as to expose the trachea, which is cleared, fixed, and opened in the same way as described above. Many different forms of tracheotomy -tube have been used from time to time, but that most generally employed consists of a double cannula, the inner portion of which can be readily removed and cleansed ; it should always be longer than the outer, in order to prevent any plug of mucus being left within the outer tube on removal of the inner. A face-plate, or some similar contrivance, is attached to the outer cannula, in order to fix and study it. One of the best is that known as Durham's lobster -tailed tracheotomy -tube (Fig. 307, A and B) ; the rigid outer tube of this instrument is introduced by means of a flexible guide set on a handle, and passed 54 Fig. 308. — Parker's Tracheotomy- tube and Introducer. (Down Brothers.) 850 A MAM UAL OF SURGERY within it. The guide is then withdrawn, and replaced by the inner flexible cannula (B). Parker's tube (Fig. 308) also has a handy introducer, and is perhaps of a better shape than most of the others, following more closely the direction of the trachea. The bivalve tube is another useful instrument ; the outer sheath consists of two lateral portions, attached to a single face-plate, and these can be pressed together, and hence with care easily inserted through the incision in the trachea. The surgeon must see that both limbs enter the trachea, as trouble has arisen from one limb passing outside, and the other inside, thus hindering the intro- duction of the inner tube. In cases of preliminary tracheotomy (p. 781), undertaken to prevent the entrance of blood during opera- tions, Halm's tube may be used with advantage ; in this the outer cannula is covered with a layer of compressed sponge which swells up from the absorption of moisture, and thus occludes the lumen of the trachea. Trendelenburg's tampon is recommended by some for the same object ; the outer tube is here ensheathed with a thin indiarubber casing, which can be distended with air at will. Difficulties and Dangers of the Operation. — Although the above description might lead the student to suppose that tracheotomy is an easy operation, this is by no means always the case, partly owing to the fact that it frequently has to be undertaken in a hurry, with perhaps inefficient assistance, and in a bad light, and partly owing to the intense vascular engorgement of the structures met with. A cool head and a steady hand are in such cases of infinitely more value to the operator than the most perfect anatomical knowledge. The following are the chief conditions which may lead to mistakes and accidents : (1) The administration of any general anaesthetic is often inadvisable in semi-asphyxiated patients, since complete cessa- tion of respiration may be caused thereby, possibly from spasm of the glottis. In such the cutaneous incision may be made under the influence of some local anaesthetic, whilst for the deeper parts of the operation nothing is required. (2) It is not always easy to find the trachea, especially in the necks of fat children, or where it is hidden by an unduly large thyroid isthmus, or possibly by the projection of the thymus gland into the neck. It is here most essential to remember the old adage, In medio tutissimus ibis, although occasionally the trachea may be displaced from the middle line by some external growth, and can then only be found by careful exploration with the finger. (3) Hemorrhage is generally troublesome. It is usually venous in character, arising either from the anterior jugular vein or from the inferior thyroid plexus. If possible, it should be controlled by pressure-forceps before opening the trachea ; but this is not abso- lutely necessary in urgent cases, since it usually ceases as soon as easy respiration through the tube has been established. The presence of the left innominate vein in front of the trachea SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST 851 must not be forgotten, although it but rarely reaches above the sternum. In about 8 per cent, of all subjects an arterial twig (the thyroidal una) courses upwards from the innominate artery along the trachea, to reach the isthmus of the thyroid body ; if divided, it can be easily secured and tied. Should much blood be inspired, it may determine the occurrence of septic pneumonia at a later date. (4) The possibility of the entrance of air into veins must not be overlooked, although it is an uncommon accident, since the intra- venous pressure is so great. (5) Not unfrequently considerable mischief has been done by an incautious use of the knife, especially if the operator forgets to fix the trachea with a sharp hook before opening it. In a child the trachea is small ; and if it is moving rapidly up and down, as happens in urgent dyspnoea, or if the child is restless, and not completely under the influence of an anaesthetic, the difficulty is manifestly increased. Many accidents have happened from this cause, e.g., wounds of the large veins or arteries of the neck, or even of the oesophagus or bodies of the vertebrae ! (6) As soon as the trachea is opened, a severe fit of coughing is induced, which is sometimes so prolonged as to interfere with the introduction of the tube. Under such circumstances the incision in the trachea may be opened up with a tracheal dilator, or by a pair of sinus forceps, and a few drops of cocaine swabbed over the mucous membrane. (7) The introduction of the tube is a matter of no difficulty if the surgeon takes the precaution of not removing the hook until this is satisfactorily accomplished. Many mistakes have followed the non-observance of this rule ; thus, the tube has missed the trachea altogether and passed into the fascial interspace in front, as also to one or other side ; as before mentioned, the outer portion of a bivalve tube has often been passed with one limb within the trachea and the other outside. A very dense diphtheritic mem- brane has also been a cause of difficulty, in that, although the tube has been really passed into the trachea, it has not penetrated the membrane, and thus has hindered rather than helped the breathing. In all cases of diphtheria the trachea should be freely opened, and the interior carefully examined by separating the lips of the incision before attempting to insert the tube. In order to prevent the downward passage of the membrane, some surgeons have recommended that the lower portion of the larynx should be carefully stuffed with antiseptic gauze above the tube. After-Treatment. — The patient is placed in bed, in a room kept at a uniformly warm temperature (75 F.), the air being moistened by the steam issuing from one or more bronchitis kettles, so as to make up for the absence of nasal and oral respiration. Draughts are excluded by curtains, and nothing should be placed 54— 2 852 A MANUAL OF SURGERY over the entrance to the tube, so that respiration may not be hindered, nor the expectoration of mucus, false membrane, etc., prevented. One of the most frequent sources of extension of diph- theria to the lungs, or of septic pneumonia, is the re-inspiration of material which has been coughed out upon a portion of muslin or gauze, placed with excellent intentions over the mouth of the tube. A nurse should be in constant attendance on the patient, in order to wipe away all such material as it is expelled. The inner portion of the tube is removed by the nurse, and cleaned two or three times a day, any inspissated mucus upon it being readily removed by the use of a solution of bicarbonate of soda (20 grains to 1 ounce). The outer tube is also removed once a day for cleansing purposes, but only by the medical attendant. Should the respiration become impeded by a collection of mucus in the trachea, a fine feather may be passed down the tube in order to clear it, but never in diphtheritic cases ; for such a con- tingency special suction-tubes have been devised. Attempts have been made to clear the passages by applying the lips to the tube, and removing the block by suction ; such is, however, quite un- justifiable, and several promising house-surgeons have in this way lost their lives. The period for which the tracheotomy-tube is kept in position varies in different cases, but its removal should always be under- taken at as early a date as possible, for fear of leading to impair- ment of the voice. In order to prevent this, the inner cannula is made with a hole in the upper end, so that part of the air may pass through the larynx. If the patient can then breathe com- fortably when the finger is placed over the entrance to the tube, its presence is no longer necessary. After-complications of Tracheotomy. — (a) The tube may give rise to ulceration of the trachea if it is not correctly shaped. Thus, if too much curved, it tends to irritate the anterior wall, and cases are known in which it has caused death by perforation of the left innominate vein. If insufficiently curved, the posterior wall may become affected, and the oesophagus laid open. In cases where a tracheotomy-tube has to be worn for a long time, it may be advisable to make use of indiarubber tubes. (b) Various forms of septic trouble may arise in the wound, leading to cellulitis, and even secondary haemorrhage ; this is especially dangerous in the low operation, since the inflammation may extend to the mediastinal tissues. In cases of diphtheria the wound may also become affected with the disease. (c) Inflammation of the trachea, bronchi, and lungs may result either from the entrance of cold, or unmoistened air, or from the inspiration of septic or diphtheritic material. (d) Difficulty is sometimes experienced in leaving off the tube, owing to the presence of granulations obstructing the lumen of the trachea, or to stenosis of the larynx from contractions or adhesions SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST S53 of the vocal cords, or even to paralysis of the abductor muscles, especially in diphtheritic cases. The trachea may also be kinked, and its calibre thus diminished, by cicatricial union of the skin and mucous membrane. The diagnosis of the cause at work in any particular case can only be made by laryngoscopy, or careful examination of the wound and upper portion of the trachea. Granulations may be scraped away under an anaesthetic or destroyed by caustics, stenosis of the larynx is overcome by dilata- tion with an O'Dwyer's tube, whilst laryngeal paralysis must be treated by the use of electricity. Fig. 309. — O'Dwyer's Intubation Apparatus. (Down Brothers. The cannulae are seen below on the right ; a hinged inner tube passes throughout the length of each, and the upper end of this is screwed to the extremity of the introducer seen in the middle ; when it has been inserted into the larynx, the trigger of the introducer is drawn, and by this means the inner tube is loosened and can be easily removed, leaving the cannula in position. To extract the tube, the rectangular forceps repre- sented at the top is utilized ; the point of the forceps is inserted into the top of the cannula, and then by opening the blades the cannula is fixed and can be withdrawn. A useful type of unilateral gag is also represented, and a small gauge to indicate the size of cannula required at different ages. 6. Intubation of the Larynx is a means of treating laryngeal obstruction which has been introduced in order to obviate the risk always present in tracheotomy. It consists in the passage through the mouth of a suitably curved tube into the larynx, by means of a specially contrived introducer. The best patterns to employ for the purpose are those known as O'Dwyer's tubes (Fig. 309). The lower end of the cannula is oval, and not circular, and passes between the cords into the larynx, whilst the 854 A MANUAL OF SURGERY upper enlarged end lies over the entrance ; it requires changing frequently in order to prevent erosion of the mucous membrane. It has been used with considerable success in cases of oedema of the glottis and laryngeal stenosis, but is scarcely to be recom- mended for diphtheria, owing to the risk of carrying the false membrane down with it. Surgical Affections of the Lungs. Wounds of the Lungs result from violence applied to the chest, with or without fractures of the ribs, or in consequence of pene- trating injuries. Non-penetrating Wounds consist either of laceration or contusion. Contusion of the king often follows some injury which is not sufficiently severe to fracture the ribs. The symptoms produced are severe pain in the side, with perhaps temporary shock and slight haemoptysis. Some traumatic inflammation follows, both of the lung and of the pleura, as indicated by loss of resonance and possibly friction sounds. The treatment consists in keeping the patient quiet in a warm room, at the same time carefully regulating the bodily functions. Possibly pain may be relieved by strapping the side of the chest. Laceration of the lung is usually secondary to fracture of the ribs, especially from direct violence. The severity of the symptoms necessarily varies with the character and extent of the injury. The patient suffers from marked shock in severe cases, associated with pain in the side and dyspnoea. Evidences of hemorrhage soon follow, either in the form of haemoptysis or haemothorax. If the wound is a small one, the patient complains of an irritating cough, and brings up a good deal of blood-stained frothy mucus ; but if the laceration is extensive, involving some of the larger pulmonary trunks, a quantity of pure blood may be ejected, even leading to death from syncope, or from asphyxia, owing to the blood filling the larger bronchial tubes. Hemothorax may also be so excessive as to cause the patient's death from compression of the lung. It results in a gradually increasing area of dulness ex- tending from below upwards, together with loss of breath sounds and vocal fremitus, coming on soon after the injury without signs of inflammation. Owing to the laceration of the pulmonary vesicles, air tends to escape either into the pleural cavity, giving rise to the condition known as pneumothorax, or into the cellular tissue of the body, constituting surgical emphysema. Pneumothorax is always asso- ciated with more or less collapse of the lung, and is almost certain to lead to considerable interference with respiration, and possibly to severe dyspnoea, or even orthopneea. The air which finds its way into the pleura, having been filtered through the lungs, is free from organisms, and hence does not cause SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST S5; suppuration or putrefaction of the blood-clot present, unless bronchitis or some other suppurative condition has existed pre- viously. The physical signs of pneumothorax consists in a high- pitched tympanitic note on percussion, and on auscultation amphoric breathing and possibly metallic tinkling. As soon as the wound in the lung commences to heal, the amphoric sounds disappear, the effused air is absorbed, and the lung gradually expands — a process which may take four or five days. If blood is also present in the thorax, a condition of haemopneumothorax is produced, recognised by a splashing or succussion sound heard on shaking the patient. Surgical Emphysema almost always indi- cates a wound of both pulmonary and parietal layers of the pleura, which are slightly separated by air, constituting a localized pneumothorax. At each inspiration a fresh amount of air enters this cavity, and is expelled into the areolar tissues through the parietal wound at each expiration, being forced perhaps to a con- siderable distance from the spot where it commences, or even spreading over the whole body. It is of no serious significance, disappearing rapidly after the wound in the lung has commenced to heal, thus occluding the opened pulmonary alveoli. It is recognised by the parts becoming swollen and puffy, and giving a sensation of fine crackling crepitus when the hand is pressed over them. Occasionally emphysema may arise as an interstitial con- dition, when the parietal pleura has not been injured, the air escaping from the alveoli along the the inter-alveolar connective tissue into the root of the lung, and then appearing first at the lower part of the neck. Such are the ordinary phenomena observed in the early stages of a ruptured lung. The effects subsequently produced consist in a localized traumatic pleuro-pneumonia, associated with slight elevation of the temperature, possibly rusty sputum, and often severe dyspnoea. In the worst cases death may result from asphyxia. Penetrating Wounds of the Lung are followed by very similar effects, modified, however, by the fact that the external wound in the chest wall allows of the exit of blood, arising either from an intercostal artery or from the wounded lung, whilst it also permits the entrance of septic organisms with the air into the pleural cavity, and thus may change the character of the result- ing pleuro-pneumonia from a simple to an infective imflammation. Empyema is consequently a frequent sequela, whilst the inflam- mation of the lung may be of a spreading nature, possibly termi- nating in suppuration or gangrene. Surgical emphysema is also induced by air being sucked into the wound during inspiration, and failing to escape during expiration, owing to the lips of the wound falling together. This condition may ensue even when the lung itself has not been damaged. Treatment. — When the rupture of the lung is due to a sub- S56 A MANUAL OF SURGERY cutaneous injury, the patient should be kept quiet in a warm room, and the side strapped. The compression of the chest wall must sometimes be omitted in patients where the irregular ends of fractured ribs, broken by direct violence, are driven inwards, for fear of increasing the mischief in the lung. Persistent haemoptysis must be treated by keeping the patient absolutely quiet, and allowing him to suck ice continually. Ergotin may be injected hypodermically, or a mixture of ergot, opium, and sulphuric acid administered ; the opium is especially needed when great restlessness and irritability are present. Stimu- lants are necessarily contra-indicated, for fear of again starting the bleeding. Haemothorax rarely needs special treatment, since the blood soon clots and is readily absorbed ; but occasionally it may be so abundant as to compress the lung and lead to dyspnoea, and under these circumstances it may be necessary to open up the pleural cavity and remove it. Such must never be under- taken until sufficient time has elapsed to permit of thrombosis in the wounded vessels. Decomposition of the blood in the .pleural cavity occasionally happens even in non-penetrating injuries, the bacteria reaching it either from the blood or from the lacerated bronchi ; the suppuration and fever thereby induced necessitate the opening and drainage of the pleural sac. Simple pneumothorax seldom requires surgical treatment, since the imprisoned air is quickly absorbed, and the lung re-expands ; but should it give rise to severe dyspnoea, it may be advisable to remove the air by aspiration. Temporary dyspnoea may be overcome by the inhalation of oxygen ; but when of a more decided character, and not due to any condition which can be removed, the essential treatment is to diminish the blood-pressure, and thus decrease the amount of blood carried to the uninjured lung, so as to enable it to cope with the work of blood-aeration. This may be accomplished by ad- ministering antimonial wine (10 to 15 minims every four or six hours) combined with full doses of liquor ammoniae acetatis ; but in urgent cases, where the patient is becoming cyanosed, and life is threatened by asphyxia, venesection must be adopted. The blood is withdrawn from the arm rapidly and freely, and as it flows the dyspnoea passes off. This may be repeated once or twice in addition to the use of the medicine before the full effect is obtained and respiration becomes unembarrassed. The treatment of penetrating wounds of the thorax, involving the lung, is always a matter of considerable difficulty. The skin around the opening is carefully purified and shaved, if necessary, and a limited exploration of the wound with a purified finger or probe is permissible, so as to determine whether portions of the clothing have been carried in, or a rib comminuted ; all such loose fragments must be removed, as also any penetrating foreign body, such as a bullet, if accessible. The greatest gentleness must, SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST 857 however, be employed, since it is easy to dislodge clots lying in the pulmonary tissues, and thereby restart the bleeding. As a general rule, it is unnecessary to syringe out the deeper parts with an antiseptic, since if one of the main bronchi has been opened, the lotion might then find its way into the air-passages. The insertion of a drainage-tube is scarcely called for as a routine procedure, but it is advisable to lightly plug the wound with gauze. The chief danger arises from the loss of blood, and, as already stated, this may come from division of an intercostal artery, or from the lung. If of intercostal origin, it should be treated as described at p. 244. Pulmonary hemorrhage is, unfortunately, not so readily controlled ; and much difference of opinion has been expressed as to the most satisfactory means to adopt in these cases. Probably the best method consists in keeping the patient absolutely quiet, and trusting to the application of cold to the side, and to the administration of haemostatics, as indicated above for non-penetrating wounds. In bad cases the haemorrhage may only cease when the patient is in a condition of profound collapse or syncope ; intravenous infusion of saline solution may then suffice to tide him over the period of danger, and lead to a successful result. Two other plans of treating pulmonary haemorrhage which have been recommended may be noted, viz., venesection from the systemic circulation so as to reduce blood-pressure, and thus obtain thrombosis ; and plugging the wound in the parietes so as to cause the blood to accumulate in the pleural cavity, and thus by its pressure lead to a similar result. Neither of these methods commends itself to us, although both are occasionally successful, and possibly would be the only plans practicable in dealing with a large number of wounded. The latter of the two has an additional objection in that it is almost certain to be followed by suppuration and septic fever, necessitating the opening and washing out of the pleural cavity at a later date. The question of opening the thorax by resecting a considerable portion of rib, so as to deal directly with the injured lung, has been raised of recent years, and several cases in which it has been undertaken have been recorded. Whether or not such practice is justifiable is a question that further experience can alone decide ; at present all w T e can say is that a surgeon should be prepared to do this operation, although only resorting to it in exceptional circumstances. The later treatment of these cases is much the same as for simple non-penetrating injuries. Should symptoms of septic pleurisy follow, the wound must be freely opened, a portion of rib being excised, if necessary, and the cavity washed out and drained, as for empyema. Hernia of the Lung, or pneumocele, is a rare condition in which 858 A MANUAL OF SURGERY a portion of the lung protrudes through an opening in the thoracic parietes beneath the uninjured skin. It may occur suddenly, as the immediate consequence of a laceration of the intercostal muscles and pleura, or more gradually, being then due to the yielding of a cicatrix. It is most usually seen about the fifth intercostal space, but has been known to occur in the root of the neck from a lesion in the dome of the pleura. It is recognised by the appearance of a rounded swelling, increasing in size on coughing or making expiratory efforts, and possibly disappearing entirely on holding the breath. It imparts a crepitant feeling to the fingers when compressed, and on auscultation a loud vesicular murmur is heard. As a rule, no treatment is advisable in this condition beyond the application of a pad or truss. A similar condition, arising as a complication of an open wound, is termed a Prolapse of the lung. An attempt should always be made to return the protruded viscus, and to prevent its recurrence by suturing the aperture through which it has escaped. If left unreduced, it is very likely to become gangrenous from strangulation, and should then be removed by the application of a ligature, the wound being subsequently closed. Empyema, or suppuration within the pleural cavity, results not only from traumatism, but also as a sequela of a simple pleurisy, or as a complication of various affections of the lungs, whilst a basal empyema is not an uncommon result of intra-abdominal suppuration. A description of the physical signs and symptoms belongs rather to the physician than to the surgeon. It will suffice to mention here that the affected side of the chest does not move on inspiration, whilst there may be some bulging of the inter- costal spaces ; on percussion the side is dull, except perhaps immediately below the clavicle, where tympanitic resonance may be elicited. On auscultation breath-sounds are absent, except in the vertebral groove, where bronchial breathing may be heard. The loss of vocal fremitus is also an important sign. A certain amount of fever and dyspnoea is usually present in cases of empyema, whilst the other thoracic viscera may be displaced. Left to itself, an empyema usually finds its way to the surface, and perhaps most commonly bursts through the fifth or sixth costal interspace, though sometimes through the second in front, owing to the perforating vessels being larger here than elsewhere. Occasionally a localized empyema is met with, giving rise to similar effects, but on a smaller scale. When situated on the left side in close proximity to the pericardium, the movements of the heart may be transmitted through the fluid to the surface, causing a pulsation which can be seen or felt (pulsating empyema). In the early stages the pleura is but little altered in structure, although a certain amount of lymph may be deposited on it ; in old-standing chronic cases it becomes very dense and firm, SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST 859 owing to a development of fibro-cicatricial tissue, whilst the surface is converted into a layer of granulation tissue, similar to that found in all chronic abscesses. The lung collapses and retreats backwards towards the spine ; at first its alveolar texture remains unaltered and the early removal of the exudation enables it to re-expand, as a result of the atmospheric pressure. In chronic cases, however, there are two hindrances to this expan- sion, viz., the density of the thickened visceral pleura, which resists the atmospheric pressure, and the infiltration and sclerosis of the lung tissue itself. Under these circumstances, even when the exudation is entirely removed, the lung may remain collapsed, and Nature then attempts in several ways to remedy the mischief and obliterate the pleural cavity: (a) The opposite lung undergoes expansion and hypertrophy, and together with the heart projects over to the opposite side ; (b) the abdominal viscera and dia- phragm are displaced upwards ; (c) the chest wall falls in, and the spine becomes laterally curved, with its convexity to the sound side ; and (d) there is an exuberant growth of granulation tissue from the surface of the pleura. In a certain proportion of cases these structural changes suffice to determine a cure, but in others a cavity still remains, lined with thickened pyogenic membrane, and discharging pus or serum, according to whether or not sepsis is present. Under these circumstances extensive operative inter- ference is necessary. The Diagnosis of empyema is readily made by attention to the physical signs, and confirmation of such an opinion can be obtained by puncture with a sterilized hypodermic syringe. A medium- sized needle should always be employed for this purpose, and it is well to insert it along the top of a rib after drawing the skin up or down, so that on removal a valvular puncture results. The character of the organisms contained in the sample of pus thus withdrawn should, if possible, be ascertained, since it has been proved that the Prognosis depends much on this point. Thus, an empyema due to the presence of pneumococci, presumably following a pneumonia, runs a mild course, and is readily cured, even by aspiration alone ; one due to the ordinary pyogenic cocci is more acute, and requires drainage with or without resection of a piece of rib. The presence of tubercle bacilli renders the outlook much more serious, whilst the addition of septic organisms to any of the above aggravates the process and much impedes a cure. The chronicity or not of the affection is also a most important element in the prognosis, since the later the treatment commences, the denser are the adhesions which bind down the lung, and the less the chance of its re-expansion. Treatment therefore should never be delayed ; the earlier it is undertaken, the better the results. Aspiration may be adopted in the first instance, but is generally to be regarded as of an exploratory nature, though a cure will 860 A MANUAL OF SURGERY occasionally follow when the empyema is of pneumonic origin. It is, however, sometimes of value in order to relieve for a time the pressure on the other lung and the resulting dyspnoea, and thus allow of the administration of an anaesthetic for the more serious subsequent operation. Drainage of the pleural cavity through an external incision is the treatment almost invariably necessary, and the opening is best made either in the mid-axillary line or a little in front of it, through the fifth costal interspace. Under special circumstances it may be necessary to open the pleural cavity at a lower level, and then the ninth or tenth interspace in the scapular line is selected. Whether a portion of rib need be removed or not, is merely a question of mechanical convenience; if the drainage-tube can be efficiently retained between the ribs without resection, well and good ; but if, as in children, the space is narrow, then a portion of rib must be removed. An incision is made along the course of a rib about i^ inches in length, and the periosteum stripped up from both the superficial and deep aspects of the bone, so as to enable a curved raspatory to be passed beneath it ; at least i inch of the rib is then cut away with bone pliers. The parietal pleura is opened sufficiently to enable the finger to be introduced and the cavity explored. A large drainage-tube is inserted, just long enough to project into the pleural cavity, and the wound immediately covered, so as to prevent as far as possible the entrance of unfiltered air. Formerly it was considered desirable to thoroughly wash out the pus ; but it has now been demonstrated that such is unneces- sary, and occasionally dangerous. Several cases of sudden death have followed this practice, probably due to reflex irritation of the vagus. In chronic cases, where sepsis has been admitted, irriga- tion is often beneficial, but the following points must be attended to : (i.) The fluid employed must be unirritating, though sterile ; (ii.) it must be at the temperature of the body, neither too hot nor too cold ; (iii.) it must not be injected with such force as to impinge against the pleura or against the upper surface of the diaphragm ; and (iv.) free exit must be given to it, so as to prevent tension from accumulation within the pleural cavity. If such treatment is undertaken sufficiently early, the lung may be expected to expand, the discharge steadily diminishing, and the wound ultimately healing; but, as we have already explained, such does not always occur, and then a fistula persists, leading into a cavity lined with a thick pyogenic membrane, discharging a variable amount of pus. The best means of obtaining a cure in these cases consists in removal of the rigid external wall, as by Estlander's operation, which is characterized by the excision of portions of ribs comprising the outer wall of the cavity. It is usually carried out through a vertical incision in the axillary line, the ribs being freed from their periosteal connections ; the amount excised necessarily SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST 86 1 varies according to circumstances, and is in some cases very extensive. The fistulous track is enlarged, and the interior of the pleura carefully curetted and washed out, so as to remove all necrotic and degenerating tissue ; the parietes are then allowed to fall back into contact, if possible, with the deeper layer, a drainage- tube is inserted, and the side firmly bandaged. A modification of this proceeding is known as Schedes operation, in which not only are the ribs removed, but also the intervening tissues, so that the subcutaneous or muscular structures in the flaps are laid down upon the prepared surface of the deeper layer of the pleura. Necessarily, either of these methods of treatment is associated with considerable deformity, and also with a terrible weakening of the side, and plans have been suggested to obviate this by removing portions of a number of ribs before and behind, so as to leave the intervening segment free to collapse without totally destroying the osseous thoracic boundary. Another proceeding that has been recently introduced and practised with success is the stripping of the thickened pleura away from the collapsed lung, so as to enable it to expand once more (pulmonary decortica- tion). Further experience is needed before any final opinion as to the merits of these operations can be given. Various operative proceedings have been directed to the lung substance itself, concerning which, however, we can but suggest a few points. Pueumotomy, or incision of the lung, has been undertaken for not a few pulmonary lesions, and the results obtained have been rather variable, i. For tuberculous cavities it is of little use. They are usually situated at the apex of the lung and drain well ; the original disease is not removed ; and the general health is frequently so impaired that the shock of the operation hastens the inevitably fatal issue. Hence it is only required in cavities located in the lower half of the lung, which drain badly, and the difficulty of diagnosing such a condition is considerable. 2. For bronchiectases pneumotomy, though prima facie desirable, has given but little benefit, since it is uncommon for only one dilatation of the bronchus to exist. In suitable cases, however, where there is a good deal of foetid secretion, which is with difficulty expelled, it may be useful. 3. In gangrene of the lung much benefit may be derived. 4. The same is true as regards pulmonary abscess following pneumonia. 5. In hydatid disease of the lung, incision and drainage have so considerably reduced the mortality that this method of treatment should alone be adopted. As to the technique of the operation, the first thing is to locate the mischief, and this is effected partly by a careful attention to the physical signs, partly by the use of an exploring needle or syringe. An incision is then made, and a portion of one or more ribs 862 A MANUAL OF SURGERY removed. If the lung is adherent to the thoracic walls, and shows no signs of retracting, the operation may be continued ; but if no adhesions are present, it may be well to stuff the wound with gauze for a day or two, so as to determine their formation and thus shut off the pleural cavity. The lung itself may be punctured with sinus forceps introduced along an exploring needle, and then opened, or may be incised with a cautery. The abscess or other cavity is thus emptied of its secretion, and a drainage-tube inserted. As a general rule it is unwise to scrape or irrigate it, for fear of a communication existing with any of the larger bronchi. Pneumectomy, or excision of a portion of the lung, has been attempted in a few cases of tuberculous disease limited to the apex ; the operation is, however, quite unjustifiable, since, if the affection is localized to the apex, it can often be cured by the physician, whilst if it is more diffuse it cannot be extirpated. Primary malignant tumours of the lung, moreover, are usually central, and the diagnosis can rarely be made early enough to warrant an attempt at removal. The only conditions under v/hich it is justifiable to excise portions of lungs are : (a) when a hernial protrusion has become strangled through a small opening, and cannot be reduced ; and (b) when malignant disease of a rib has invaded the superficial portion. In the former case, the base of the protrusion is transfixed and ligatured prior to being cut away ; in the latter, the disease is snipped away with scissors, and bleeding stayed by cautery, ligature, or plugging. Wounds of the Heart. Wounds of the Heart and great vessels are so usually fatal either immediately or within a few hours, that it is unnecessary to discuss them here in any detail. If the patient does not die at once, he suffers from intense shock and prostration, combined with a weak and turbulent action of the heart, great pain in the chest and dyspnoea, whilst the pulse is scarcely to be felt. Free haemorrhage occurs if there is an external wound, but if the opening in the pericardium is small and valvular, the heart's action may be brought to a standstill by the pressure of the blood within. Should the patient survive, pericarditis generally super- venes, and is often of a purulent type. As to Treatment, the great essential is to keep the individual absolutely quiet, and with the head low. The external wound should be purified, but during the stage of primary shock no attempt should be made to explore it, either by finger or probe, for fear of dislodging a clot. Later on the question of exploration may be raised, and more than one case has now been published in which the surgeon has success- fully sutured a stab-wound in the ventricle. To expose the heart for this purpose it is usual to turn up a trap-door flap of the chest wall, including portions of the fourth and fifth costal surgery of the air-passages, lungs, and chest 863 cartilages and ribs. Other cases are reported in which a wound of the heart has healed spontaneously, and the patient survived for many years. Effusion into the Pericardium, whether serous or purulent, may occasionally require surgical treatment in order to relieve symp- toms of cardiac failure, due to the pressure of the exudation. For serous pericarditis all that is needed is to aspirate the cavity. This is usually undertaken close to the left border of the sternum in the fifth interspace, or i| inches from the left margin of that bone through the fourth or fifth interspace, so as to avoid the internal mammary trunk, which courses down about a finger's breadth from the border. For suppurative pericarditis an incision may be made in the Fig. 310. — Artificial Respiration by Sylvester's Method (First Stage). The arms are grasped just above the elbows, and raised well above the head so as to expand the thorax. same situation after removing the fourth or fifth costal cartilage, the cavity washed out, and even a drainage-tube inserted. Care must be taken to prevent infection of the mediastinal tissues, and this can sometimes be accomplished by stitching the pericardium to the parietes before opening it. Asphyxia. Asphyxia, or Apncea, is the term applied to indicate the condition arising from interference with or stoppage of the respiratory act. If this has not proceeded to any great extent it is termed Dyspnoea; when, however, the obstruction is so marked that the patient is obliged to maintain the upright sitting position, the term Orthopnea is applied to it. The Causes of asphyxia may be classified as follows : 1. Conditions arising from the presence of abnormal contents within the 864 A MANUAL OF SURGERY air-passages, e.g. , foreign bodies, blood-clot, or pus from the bursting of an abscess or aneurism ; serum, as in oedema of the lung ; mucus or muco-pus, as in bronchitis ; the consolidated exudation in pneumonia ; diphtheritic mem- brane ; or irrespirable gases ; e.g., nitrogen, hydrogen, carbonic acid gas, etc., as in suffocation. Death by drowning usually arises from a similar cause, viz., the replacement of air by water in the respiratory passages. 2. Causes arising in the walls of the air-passages, such as diminution of their lumen from inflammatory congestion, as in oedema of the glottis; cicatricial stenosis ; the presence of new growths, or the displacement of parts, as in cut throat ; or the falling back of the root of the tongue after partial excision of that organ. 3. Extrinsic causes, or those arising outside the air-passages, e.g., in the neck : strangling, hanging, garrotting, etc. ; the presence of tumours, such as Fig. 311. -Sylvester's Method of Artificial Respiration (Second Stage). The arms are brought down to the side, and pressed firmly inwards against the thoracic parietes so as to expel the air. These two stages are alternately repeated about fifteen times in the minute. goitres or aneurisms ; a retro-pharyngeal abscess or tumour, and, under exceptional circumstances, displacement backwards of the sternal end of the clavicle. Within the thorax gradually increasing obstruction to the respiration may be caused by the presence of tumours, aneurisms, or effusion into the pericardium or pleura. 4. Nervous causes, e.g. , paralysis or spasm of the larynx, and paralysis of the diaphragm, either from peripheral lesions, such as the pressure of aneurisms or tumours on the nerve trunks, or from central causes, such as a lesion in the upper part of the spinal cord or medulla. It may also arise from paralysis of the respiratory centre, as from an overdose of chloroform. 5. In many forms of cardiac disease the lungs may become engorged with stagnant blood, leading gradually to dyspnoea, orthopnoea, and finally asphyxia, owing to the increasing difficulty in eliminating the excessive accumulation of carbonic acid. SURGERY OF THE AIR-PASSAGES, LUNGS, AND CHEST 865 The Treatment of the different conditions giving rise to asphyxia cannot here be dealt with in extenso. We can only indicate the general plan of treatment to be adopted. A rapid examination is at once made, to ascertain, if possible, the cause of the mischief, and whether its onset has been gradual or sudden. If it has been gradually developing, it is not uncommonly due to some thoracic condition which cannot be relieved ; if, however, its onset has been sudden, and not the result of any evident lesion, the neck and chest should be bared, and examined for signs of traumatism, the mouth opened, the tongue drawn forwards, and the glottis examined with the finger to see that the passages are clear. The patient should, if necessary, be removed into fresh air, and arti- ficial respiration at once commenced. Breathing can sometimes be excited by alternately dashing hot and cold water over the thorax, whilst electric stimulation of the phrenic nerve may also be undertaken, one electrode being placed over the neck, and the other on the epigastrium. The administra- tion of oxygen instead of air is useful during the earlier stages, whilst if the condition is due to cardiac disease with distension of the right side of the heart, venesection holds out the best hope of relief. Obstruction within the larynx needs tracheotomy or intubation, as also other conditions associated with pressure on the trachea. In cases of threatened death from drowning, the first care must be directed to clearing the air-passages and mouth of water, weeds, etc., by rapid inver- sion, drawing the tongue well forwards, and swabbing out the pharynx ; or the patient is turned on his face, with a firm pillow, or coat rolled up, placed beneath the thorax ; and the chest is compressed so as to help in the evacua- tion of the water, which runs out of the mouth. Artificial respiration can then be commenced. Artificial Respiration is required in a variety of surgical conditions, and is best undertaken by what is known as Sylvester's method. In this the patient lies on his back, with a pillow beneath the shoulders, the mouth opened, and the tongue drawn forwards. The arms are then grasped just above the elbows and drawn upwards above the patient's head, so as to expand the chest through the action of the great pectoral muscles (Fig. 310). This position is main- tained for about two seconds, and then the arms are lowered to the side, and pressed firmly against the ribs, so as to determine a forcible expiratory act (Fig. 311). At the end of about two seconds more the arms are again elevated, and the same cycle passed through. This should be repeated about fifteen times a minute, and the operator must be careful not to use too great violence, or to unnecessarily hurry over it, as harm rather than good thereby results. Another less satisfactory method consists in alternately compressing the lower part of the thorax and abdomen with the hands, so as to drive out a certain amount of air, and then by suddenly relieving the pressure the elastic expansion of the chest walls draws in a fresh supply 55 CHAPTER XXXI. DISEASES OF THE BREAST. Congenital Malformations of the breast are much more common than is usually supposed. One or more accessory breasts or nipples are found either below the normal one or just above it, but sometimes they have been found in the axilla, on the outer side of the thigh, or other curious situations. They are often of a most rudimentary nature, but in a few cases they have secreted milk. The existence of these structures probably explains the occasional origin of cancer in unusual situations, such as the axilla. Very rarely the breasts are entirely absent. Affections of the Nipple. Fissures of the Nipple (cracked nipples) seldom occur apart from lactation, and may usually be traced to a want of care and cleanli- ness on the part of the mother, associated with a tender condition of the skin, which might have been prevented by bathing the parts during the later weeks of pregnancy with spirit, so as to harden them. The actual lesion is brought about by leaving the nipples wet after nursing. The superficial layers of epithelium become macerated, and are easily rubbed off, thus exposing the more delicate and sensitive deeper parts, which are irritated and inflamed by the repeated acts of suction. As a result, nursing becomes painful, and if persisted in, the wound may be infected, the inflammation spreading to the breast substance along the duct or lymphatics, or extending along the superficial lymphatics to the axillary glands. Treatment. — The best way to prevent the occurrence of cracks is to bathe the nipples with some dilute antiseptic, such as boric lotion, immediately after nursing, and then to dry them thoroughly. If at all tender, a little powdered boric acid and starch may be dusted over them in the intervals. When a fissure has formed, it should be dressed with cooling or antiseptic lotions — e.g., lotio plumbi or lotio acidi borici. Sometimes more stimulating appli- cations are required, such as a solution of sulphate of copper, DISEASES OF THE BREAST 867 or even of nitrate of silver. It is also recommended to paint the sore with equal parts of glycerine and sulphurous acid. Eczema of the Nipple may be of a simple nature, needing nothing but ordinary treatment, or it may take on special features, being then known as Paget's Disease (dermatitis maligna), a condition by some supposed to be due to the presence and action of psorosperms. It presents a smooth, red, raw surface, discharging an abundant yellowish viscid fluid, and may occasionally spread widely beyond the areola. It is almost invariably a precursor of cancer, and, indeed, some authorities maintain that from the first the disease is malignant, and not eczematous, in nature. The cancerous tumour is usually located beneath the nipple, and may resemble either a duct cancer, or an ordinary scirrhus. No local treatment is of any avail, and the disease, when once recognised with certainty, is best treated by removal of the breast and axillary glands. Abscess of the Areola is not uncommon in young girls about the age of puberty, arising in the sebaceous follicles, and requiring no special notice. Chancre of the Nipple is rarely seen in the mothers of syphilitic children (Colles's law, p. 136), but much more commonly in wet nurses. Primary Tumours of the Nipple are met with, such as papilloma, sebaceous cysts, and occasionally epithelioma. Inflammatory Affections of the Breast. Acub3 Mastitis is naturally most often observed is puerperal women, owing to the sudden establishment of function in the breast after the birth of a child, and to its maintained activity during lactation. It results most commonly from a sore or cracked nipple, through which pyogenic organisms find their way into the breast substance, either along the lymphatics or the gland ducts. In the former case the inflammation is mainly interstitial in character, the pus diffusing itself widely between the lobules ; in the latter the pus forms primarily within the alveoli of the glandular substance, but subsequently spreads beyond it. Simple obstruction to one or more of the ducts from inflammation of the nipple, without any external wound, also determines inflammation, which is frequently non-suppurative in character. In non-puerperal women acute mastitis may result from injury, or may be pyaemic in origin. Occasionally a metastatic inflammation of the breast occurs after the disappearance of the parotid swelling in mumps ; whilst in girls about the age of puberty a subacute inflammation, involving both the breast and areola, and even terminating in suppuration, has been observed. In newly-born infants a similar inflammation, occasionally running on to suppuration, has been seen, possibly resulting from an infection of the gland ducts during birth with cocci from the maternal passages. A slight enlargement, with congestion of the 55—2 868 A MANUAL OF SURGERY breasts, often occurs after birth, and may be due to, or is certainly aggravated by, the foolish habit followed by ignorant midwives of pulling or forcibly squeezing them in order ' to break the nipple- strings.' Signs and Symptoms. — An inflamed breast is characterized by the organ becoming swollen, acutely painful, and tender. The gland lobules are felt to be enlarged and indurated, whilst if lactation is progressing, the secretion is to some extent impaired ; but owing to the inability of the mother to allow the child to relieve the organ, on account of the pain produced thereby, considerable ten- sion results from accumulation of milk. If suppuration follows, the skin over the breast becomes red and cedematous, and, according to the situation of the pus, three different forms of acute abscess of the breast are described : (a) Supramammary abscess is the term applied to a collection of pus in the sub- cutaneous tissue ; it is often entirely unconnected with the organ, or may originate in the superficial lobules. It is strictly limited, and does not burrow deeply, coming readily to the surface. (b) An intvamammavy abscess is that most commonly met with, the pus developing within, and distending the lobules, or infiltrating the cellular tissue around them ; it is usually diffused widely throughout the organ, and may point at several spots. When very acute, or in debilitated women, especially if it has been allowed to progress without treatment, the inflammatory process may actually determine gangrene of the glandular tissue, (c) A submammary abscess is one forming in the cellular tissue beneath the breast. It may spread from the deep lobules, but more frequently arises in connection with disease of some of the adjacent ribs or cartilages, or as a cellulitis. In these cases the breast is pushed forwards, and becomes prominent, floating, as it were, on a bed of pus. The abscess usually points at the periphery of the organ, perhaps in several places, but most com- monly at the lower and outer quadrant. Inflammation of the breast occurs in women who are anaemic and weakly. Even the simple forms are associated with some fever and malaise, and this becomes greatly exaggerated if suppuration ensues, owing partly to the severe pain thereby induced, and partly to the absorption of toxins. The Treatment of simple acute mastitis consists, in the first place, in supporting the inflamed gland by means of a sling or bandage, and in binding the arm to the side, so as to keep at rest the pectoral muscle, on which it lies. Fomentations are then applied, and any tension due to retained secretion is relieved by the breast-pump. The bowels are opened, and the patient placed on a light and nourishing diet, whilst stimulants and tonics, such as iron and quinine, may be judiciously administered. As soon as the acute stage has passed, friction with warm oil, or the inunction of a belladonna ointment, is advisable. DISEASES OF THE BREAST 869 When suppuration is threatening, the breast may be poulticed until fluctuation is detected ; but under no circumstances must the abscess be allowed to burst into the poultice, and thus become septic. If such a practice is permitted, chronic suppuration ensues., and the breast may become riddled with sinuses. The most rigid asepsis must be maintained in these cases, and as soon as pus is evidently present, an incision should be made to permit of its escape. In the supramammary variety it matters little in which direction the cat is made, since the pus is always superficial to the breast tissue. In the true intvamammary abscess, the incisions should radiate from the nipple. One or more may be needed, and these should be made with a free hand, so as to allow of the insertion of the finger, and the opening up of any pockets or lobules which are distended with matter. A drainage-tube is inserted for a time, and gradually shortened day by day, until its entire removal is permissible. When the chief incisions are needed above the nipple, it is often wise to make a counter-opening in the lower half of the breast, and generally on the outer side, to permit of more efficient drainage. With such treatment the best of results may be attained, and it is interesting to note how quickly the contour of the breast is restored, and how slight is the permanent injury inflicted on the parts. The submammary abscess is best opened towards the lower and outer side, but also at any spot where pus points. If septic sinuses persist after an abscess has burst, their orifices should be enlarged, and their walls thoroughly scraped and dis- infected ; deep cavities should be efficiently drained and stuffed with gauze, so as to ensure the wounds healing by granulation. Chronic Mastitis occurs in two forms — one, a localized affection of one segment of the breast (chronic lobar mastitis), the other involving the smaller lobules and interstitial tissue (chronic lobular or interstitial mastitis). 1. Chronic Lobar Mastitis is by no means unfrequent as a result of imperfect involution of the organs at the cessation of lactation, but may arise from blows or squeezes, and especially in young women ; it may also follow a subacute or acute attack, which has not ended in suppuration. It is characterized by an enlargement of one or more lobes of the organ, which are usually tender, and often excessively painful, the pain being of a neuralgic character, and increased during menstruation. The condition is of comparatively little importance, but may give rise to a great deal of anxiety and worry. All that is necessary in the shape of Treatment is to support the part and keep the arm at rest in a sling, whilst an ointment containing belladonna, or a belladonna plaster, may be applied. 2. Chronic Lobular or Interstitial Mastitis is an affection of much interest, which occurs most frequently in women with small or atrophic breasts, who have passed, or are near to, the climacteric, 870 A MANUAL OF SURGERY being then merely an exaggeration of the sclerosis which occurs normally at that epoch. It is, however, sometimes met with at an earlier age. Pathologically, it is characterized by diffuse over- growth and infiltration of the connective tissue, which becomes sclerosed and thickened. This is associated with well marked epithelial proliferation, so that sometimes in the earlier stages the acini are filled with a thick cheesy or grumous material which can be squeezed out in thread-like masses, often of a dirty brown or greenish-yellow colour. Cysts are formed in the gland tissue, partly by liquefaction of this proliferated epithelium, partly by exudation into the acini of serous fluid, which is unable to find an exit owing to the pressure of the interstitial growth. Such are known as ' involution cysts,' and the fluid contained therein is usually clear and limpid ; but may be brown and turbid, from admixture of blood ; intracystic growths are not present. As a rule, many of these cysts are scattered widely through the breast substance, but they are small and insignificant ; occasionally one or more of them become notably enlarged, and give the patient the impression of a tumour. Clinical History. — The condition often passes unnoticed in the early stages, until a distinct lump has formed, which is nodular and indurated to the touch, and often very painful. The breast may be somewhat enlarged, and there is, perhaps, some retraction of the nipple, owing to contraction of the interstitial tissue ; but this is by no means an essential feature. A scanty serous dis- charge from the nipple is sometimes noticed. The skin seldom becomes adherent to the swelling, whilst the lymphatic glands in the axilla may be enlarged and tender owing to sympathetic irritation. On careful examination of the breast, the affection is rarely limited to one particular region, for although a distinct enlargement of one portion may be present, yet the whole organ feels more or less ' lumpy,' and not unfrequently the other breast participates in the same change. Small, rounded, elastic spots can often be detected on careful palpation, and indicate the presence of cysts. There may be but little pain, although this is sometimes one of the most marked features of the case ; it is of a neuralgic type, and usually increased at the menstrual periods. If left to run its course, the disease may remain much in the same condition for many years, and even in time disappear ; but more frequently it slowly progresses, and then results in one of three conditions : (a) General atrophy, the breast becoming shrunken, hard, and nodular, (b) More frequently general cystic disease follows, a condition in which the organ becomes trans- formed into a number of cysts held together by dense connective tissue, (c) There is some question as to whether or not cancer is a sequela of this disease ; but there is abundant evidence to prove that any continued source of irritation in an organ like the breast DISEASES OF THE BREAST S71 renders an individual with a cancerous tendency more liable to its development. The Diagnosis is sometimes easy, but the condition often simulates somewhat closely a scirrhous tumour. The chief points of distinction, however, lie in the facts (i.) that the whole breast is more or less involved ; (ii*.) that the opposite organ is very often similarly affected ; (hi.) that enlargement of the axillary glands is less common than in scirrhus, and even if en- larged they are not hard, as in the latter disease ; (iv.) that the skin is usually free from the mass ; (v.) that the tumour is never adherent to the pectoral fascia, nor is it of the stony hard- ness of a scirrhus; and (vi.) that it is often more disseminated and less defined than a cancerous growth. (vii.) Moreover, on careful palpation with the flat of the hand, it is often impos- sible to make out any distinct lump, the so-called tumour merging into the surrounding tissues ; this never occurs in scirrhus, the growth always being easily detected with the flat of the hand. Small cysts can also be felt as localized elastic spots in the in- flammatory mass. Of course it is possible for the two conditions to co-exist, and in doubtful cases an exploratory incision, and microscopic examination of a portion of the tissue, can alone be depended on. Treatment. — In the early stages friction with some sedative application may be used at the same time that the breast is supported, and freed from the irritation of badly-fitting stays. Firm and equable pressure, as by strapping, is also useful in some cases, whilst iodide of potassium may be administered. If a definite tumour is present, or if many cysts can be detected, and especially if the patient is anxious and worried about herself, it is wise to remove the affected portion, or even better to excise the whole breast, especially when there is a family history of malignant disease. Localized or Encysted Chronic Abscess is usually associated with pregnancy, and is characterized by the formation of an indurated mass in the breast substance, which slowly softens, giving rise to a sense of fluctuation, although when the abscess walls are very thick, as is often the case, it may be exceedingly difficult to detect this. Retraction of the nipple is not uncommonly present, and the axillary glands may be enlarged. The condition has frequently been mistaken for a tumour, but is recognised from it by its incorporation with the breast substance, by its lack of definition, and by the fact that on careful examination elasticity can be felt at its centre, which is almost always less resistant than the margin, whereas the opposite is the case with a tumour. In cases of doubt the insertion of a grooved needle or an exploratory incision will settle the diagnosis. Some few of these chronic abscesses of the breast are of a tuberculous nature. $Ji A MANUAL OF SURGERY Treatment consists in opening the abscess cavity, scraping out its interior, disinfecting with pure carbolic acid, if tuberculous, and draining or stuffing it. Diffuse Tuberculous Disease of the breast is very uncommon. Scattered nodules of caseous material are developed in the inter- acinous tissue, which break down into pus, and come to the surface at various spots. The breast may thus become riddled with sinuses discharging caseous pus. It may be associated with tuberculous disease of the lungs, whilst a like affection may arise secondarily in the axillary glands ; possibly in some cases the primary trouble lies in the glands, the breast being subsequently involved. Treatment should be carried out, if possible, by incision, scraping, and purification of the cavities ; but if the tuberculous foci are multiple, it is wiser to amputate the breast. Occasionally a chronic tuberculous submammary abscess forms as a result of a similar affection of the ribs or costal cartilages. It develops slowly, pushing the breast forwards, and is easily recog- nised, although the causative lesion can only be ascertained by exploration. It must be opened thoroughly, and its wall scraped and disinfected, whilst attention is also directed towards the affected bone. Syphilitic Diseases of the Breast. — As already pointed out, a primary sore may be met with on the nipple ; secondary mucous tubercles, or condylomata, are found in a similar situation or beneath a pendulous breast, whilst superficial and deep gummata have in rare cases formed in the tertiary period of the disease. Cysts of the Breast. When the structure of the breast, its abundance of ducts and alveoli, and its complex lymphatic distribution are considered, it is not surprising that many different forms of cystic changes are associated therewith. The following are the more important : i. Acinous or Retention Cysts arise, as the name suggests, from some obstruction to the ducts or lobules, whereby the secretion of the organ is unable to escape. They are met with most frequently in women during or after the puerperal period, a milk cyst, or galactocele, being then produced. It usually results from compres- sion of one or more of the ducts, connected with a sore nipple, and contains inspissated milk ; it forms a rounded swelling, and is located near the nipple. The wall is lined with cuboidal 01 columnar epithelium, according to whether a portion of the lobule or the duct itself is implicated ; if, however, it attains any great size, the epithelium may become flat and squamous. This is sur- rounded by a fibro-cicatricial layer, the thickness of which increases with the chronicity of the case. It is treated by laying the part open, removing the contents, and stuffing or draining the cavity. DISEASES OF THE BREAST 873 Similar glandular cysts form, as already described, in the course of chronic interstitial mastitis, and are then known as involution cysts ; in long-standing cases, general cystic disease of the breast may supervene. Retention cysts have also been described as resulting from irritation of the nipple, as, for instance, when a young non- pregnant woman constantly puts a baby to her breast ; the organ becomes enlarged, the epithelium proliferates, and a thin serous fluid is secreted, which does not entirely escape and by its distension of the lobules gives rise to what may be termed irritation cysts. They may in time undergo spontaneous absorp- tion, but Erichsen describes a case of this nature in which the swellings did not disappear until the patient subsequently became pregnant. Again, one frequently finds cystic dilatation of the ducts and lobules arising in connection with certain tumours of the breast, such as duct papilloma, duct cancer, or cysto-adenoma. In the latter cases haemorrhage from the contained growth is often seen, giving rise to a blood-stained discharge from the nipple. A scirrhous growth also occasionally starts from the wall of an acinous cyst. In most of these retention cysts, discharge from the nipple occurs on squeezing the organ. 2. Interacinous Cysts develop in the interstitial tissue of the breast. (a) Serous C/sbs originate, it is supposed, from a dilatation of lymph spaces. They may be uni- or multi-locular, perhaps more frequently the latter. They are lined by a smooth, shiny layer of endothelium, and contain serum, perhaps blood-stained, and in old-standing cases cholesterine ; being separate from the gland- substance, they never give rise to a discharge from the nipple, and intracystic growths are unknown. They are usually surrounded by a wall of connective tissue which may become exceedingly thick and dense. Occasionally, however, they project under the skin, and if the walls remain thin, fluctuation, and even trans- lucency, can be observed, leading to the condition sometimes badly termed a hydrocele of the breast. The Diagnosis of a serous cyst, if the wall is thick, is often a matter of considerable difficulty, as it resembles in many ways a scirrhus. It is recognised, however, by the facts that the growth is incorporated with the breast substance, usually occurring near its under surface ; that on careful examination an elastic resistance is transmitted to the fingers, quite distinct from the stony hardness of a scirrhus ; that there is no retraction of the nipple, and no enlargement of the axillary glands, whilst, as a rule, the patient complains of but little pain. The diagnosis in cases of doubt may be readily determined by inserting a grooved needle, or by an exploratory incision, which should be made of sufficient depth to 874 A MANUAL OF SURGERY ensure the thorough division of the mass, for fear that a small cyst surrounded by walls of fibrous tissue, half an inch, or even an inch, in thickness, should be mistaken for a solid tumour. Treatment. — Although it may suffice to lay the cavity open and drain it, it is decidedly wiser to remove it completely. (b) True Hydatid Cysts are occasionally met with, manifesting the general characteristics described at p. 189. 3. Cysts may also arise in connection with cancerous or sar- comatous tumours, from degeneration of tissue in the former case, and from haemorrhage into the substance of the latter. 4. Dermoid Cysts are described; but it is a little doubtful whether old galactoceles have not been mistaken for them. Tumours of the Breast. In investigating any case of tumour of the breast, the surgeon must never arrive at a hasty conclusion, but only give an opinion as to its nature after a careful and detailed examination. Thus, the age and previous history of the patient should be considered, as also the family history. Simple tumours generally arise at an earlier date than the malignant, whilst the sarcomata usually affect younger individuals than the carcinomata. There can be little doubt, moreover, as to the occasional tendency of tumours to run in families. The length of time for which the swelling has been observed should be ascertained, and whether or not it varies in size at the menstrual periods. The general appearance of the patient should be noted, as also the fact whether or not pain, local or neuralgic, is experienced. It is not unusual for pain to be referred to that part of the shoulder supplied by the posterior division of the second intercostal nerve, the anterior branch of which goes to the breast. A careful inspection of the organ should then be made, comparing it with the opposite breast, so that any signs of asymmetry may be noted. Dimpling of the skin, projection of the tumour or of the whole gland, and the situation and condition of the nipple, are the chief points to which attention should be directed. Examination of the tumour with the flat of the hand, accompanied by gentle pressure of the finger-tips, must then be undertaken ; it is not enough to pick up the breast substance between the fingers, as thereby false impressions are obtained. The relation of the tumour to the gland, its shape, its consistency, whether fluctuating or not, and its mobility on super- ficial, deep and surrounding parts should all be investigated. To this end the breast must also be examined with the arm raised well above the head, so as to put the fibres of the pectoralis major on the stretch ; transverse movement of the organ across the fibres is always possible, unless the growth is fixed to the thoracic wall ; movement in the direction of the fibres is at once limited if the tumour has invaded the muscle, or even if the overlying fascia DISEASES OF THE BREAST 875 is seriously involved. Finally, the lymphatic glands in the axilla must be carefully examined, as also, in suspicious cases, the supraclavicular glands and the opposite breast and armpit. The chief types of tumour met with in the breast may be arranged in three groups : the adenomata, the sarcomata, and the cancers. A few other conditions have been observed, but are so rare that they need no special description, e.g., lipoma, fibroma, chondroma, and osteoma. Adenoid Tumours of the Breast. — Four different varieties of tumour are included in this group, viz., the adenoma, adeno- fibroma, the so-called adeno-sarcoma, and the cysto-adenoma. Each of these is characterized pathologically by the following conditions : (a) Spaces lined by cuboidal epithelium are present in all ; they may be tubular or slit-like in nature, simulating normal gland tissue, or they may become distended and cystic, (b) The epithelium lining their walls is in one or more layers, but scarcely ever arranged so methodically or evenly as in the normal structure. It is always limited by the basement membrane, and has no tendency to extend beyond it. (c) The spaces usually contain fluid, more or less abundant according to the amount of dilatation present, and generally serous in character, though perhaps brown or reddish in colour from admixture with blood, (d) Not un- frequently intracystic growths are present, and in one form, the cysto-adenoma, these are a specially prominent feature of the case, (e) The alveolar spaces are surrounded by interstitial tissue, which may vary considerably in amount, and be either simple or complex in structure. Pure Adenoma Mammae is said to exist when the proportion of interstitial tissue to gland substance is similar to that which obtains elsewhere in the breast. It is very uncommon and requires no special notice, the clinical characters not differing from those of fibro-adenoma, and its pathological nature being only specifically recognised on microscopic examination. Fibro-adenoma (or Adeno-fibroma) is the most common mam- mary tumour met with in young people before the age of thirty ; it is often attributed to a blow or squeeze, and doubtless correctly. It occurs as a more or less rounded or oval mass, which, if placed superficially, moves freely in the breast substance, and, indeed, may be described as floating in it (Fig. 312) ; if situated deeply, it still appears freely moveable, but its definition is less evident. Sometimes several such growths are found in the same breast. A fibro-adenoma is usually firm, and more or less elastic in con- sistency, of slow growth, whilst it may be either painless, or in anaemic and neurotic women exceedingly painful, the pain often increasing at the menstrual periods. There is no concurrent enlargement of the axillary glands, unless arising from other causes, and no retraction of the nipple, with which it is entirely unconnected, whilst the skin over it does not dimple. The general S76 A MANUAL OF SURGERY health is unimpaired unless the patient is suffering from an associated anaemia. On section after removal the tumour is of a greyish-white colour, becoming pink on exposure to the air. It is more or less foliated in texture, being compared by Virchow to the section of a cabbage ; no juice can be obtained on scraping the cut surface with a scalpel, although on pressure some fluid of a thick glutinous or mucoid nature may escape. Microscopi- cally, the tumour consists of imperfectly developed glandular elemenis, surrounded by a considerable amount of firm interstitial tissue, but ducts are never present. The tumour is distinctly encapsuled, except at the one spot, through which vessels enter, and at which it is connected with the neighbouring mammary tissue. It is stated that fibro-adenomata are occasionally con- Fig. 31: -flbro- adenoma mamm.e. (from mltseum of roval College of Surgeons.) verted into sarcomata, thus changing their type from simple to malignant ; the evidence, however, as to this is not conclusive. The Diagnosis is readily made if the above signs are considered. An adenoma differs from chronic interstitial mastitis or a serous cyst by its exact definition and free mobility, whilst from malig- nant tumours it is distinguished by its slow rate of growth, and its freedom from adhesions either to the skin or to surrounding parts. The Treatment consists in its removal, which is easily effected by cutting down upon the tumour in a direction radiating from the nipple, until the capsule is reached, when the mass is enu- cleated from its surroundings with a few touches of the knife. Diffuse Hypertrophy of the breast (Fig. 313) is usually fibro- adenomatous in nature, and consists of a general enlargement of the organ, both gland substance and interstitial tissue participating DISEASES OE THE BREAST 877 in the process, and hence the breast becomes firm and indurated. It may be uni- or bi-lateral, perhaps more frequently the latter, and generally occurs in adolescents. The size varies considerably, but the breasts may become enormous, hanging down by their weight, and perhaps to such an extent as to rest on the knees of the patient when sitting. They are usually painless, although sometimes neuralgia is noticed. Functionally they are useless, as even if the patient becomes pregnant, secretion of milk but rarely occurs. The only treatment is amputation. Fig. 313. — Diffuse Hypertrophy of the Breasts. It occurred in a girl aged sixteen and a half years, and both organs had to be removed. The left breast weighed gh lbs., the right breast 9 lbs. The so-called Adeno-sarcoma is very similar in type to the adenoma, differing from it mainly in the increased rate of growth, in its soft consistency, and in the fact that the interstitial tissue is of a more embryonic character, and, indeed, is often of a mucoid nature. It is really a soft fibro-adenoma, and usually occurs in women at a somewhat earlier period of life than sarcoma or cancer — viz., between the ages of twenty-five and thirty-five. It may consist from the first of a localized tumour, increasing rapidly in size, or it may possibly commence as a simple hard or chronic fibro-adenoma, which, after remaining quiet for a time, takes on a more active development. It remains, however, 8 7 8 A MANUAL OF SURGERY throughout its course strictly encapsuled, and when large may lead to pressure atrophy of the true gland substance. It is soft and elastic in consistency, usually painless, and freely moveable on the surrounding breast tissue. The skin over it remains healthy, although distended and atrophic when the tumour is of large size ; the nipple shows no sign of retraction ; the axillary glands are not involved, and there is no systemic invasion. On removal the section is similar to that of a fibro-adenoma, but cysts are often present, as also areas of mucoid softening, somewhat resembling sago. It can be readily removed in its entirety, and does not tend to recur. Cysto-adenoma (Syn. : Cysto- sarcoma, Adenocele, etc.) is a con- dition characterized by a marked development of intracystic growths, fibro-papillomatous in nature, within the dilated acini Fig. 314. — Cysto-adenoma Mamm.t.. (Museum of Royal College of Surgeons.) The fibro-papillomatous growths are seen projecting from a large cyst, into which a bristle, passed down the nipple, enters. A glass rod has been passed through a perforation in the skin into the cyst. of a newly-formed mass of adenomatous tissue, or within the smaller ducts (Fig. 314). It usually has a definite capsule, and then the normal gland tissue may be pressed aside, and perhaps atrophies. Several cysts are, as a rule, present, and may be of great size, the intracystic growths also varying in amount. These latter consist of branched processes something like a cauliflower in appearance, covered with cuboidal or columnar epithelium ; they are exceedingly vascular, and haemorrhage into the cavity of the cyst frequently occurs, as also a blood-stained discharge from the nipple. They are due to a proliferation of the interacinous tissue, which pushes the epithelial wall of the duct or acinus DISEASES OF THE BREAST 879 before it. The tumour produced is irregular in outline, owing to the projection of the cysts ; it is usually painless, and unaccom- panied by enlargement of the axillary glands ; if of large size, blue veins are seen coursing over it. In the later stages the capsule becomes adherent to the integument, and, finally, owing to the pressure of the tumour, the skin may give way, allowing the growth to protrude. Such will be followed by the development of a fungating mass, which bleeds readily, and becomes extremely offensive. With care a probe can be passed between the intra- cystic portion of the growth and the thinned and stretched skin, which has merely given way, and is not incorporated with it ; this fact is a ready means of distinguishing this condition from a fun- gating encephaloid cancer. The tumour is essentially benign in nature ; it is never disseminated generally, and can be readily and completely removed, so that there is but little tendency to recur. In the early stages it is unnecessary to take away the entire breast if the tumour can be efficiently dealt with otherwise, but in the later stages the whole organ should be excised. Somewhat similar in nature to the above is the condition known as a duct papilloma. This is characterized by the development of a soft polypoid papillomatous mass, generally of small size, in the interior of one of the terminal galactophorous ducts, which in consequence becomes dilated. A discharge of blood-stained serum results, and there is usually but little tumour to be felt, although the nipple may be slightly pushed forwards and rendered pro- minent. It is often the precursor of a duct cancer. Amputation of the breast will in many cases be needed, although it may be feasible in some to deal with the tumour alone. Sarcoma of the Breast is not a common disease. It originates in the connective tissue of the organ, being deeply placed in its substance, or perhaps more frequently developing in the outer and upper quadrant. It is of two chief types : (a) The round- celled sarcoma forms a soft, somewhat elastic swelling, which grows rapidly, and although often limited at first by a fibrous membrane, the capsule tends sooner or later to give way, allowing the growth to become diffused through the organ. It sometimes gives rise to secondary growths in the axillary glands, or becomes disseminated throughout the body by means of the bloodvessels. Cysts often occur in its substance, resulting either from haemor- rhage or occasionally from the dilatation of an incorporated glandular alveolus ; in the latter case the cavity will be lined with epithelium. Myxomatous changes are also not ^infrequently observed, and in the more rapidly growing recurrent tumours the mass is often a true myxo-sarcoma. It usually occurs in women between the ages of thirty and forty, i.e., somewhat earlier than scirrhus, whilst its rapid growth and the absence of retraction of the nipple or dimpling of the skin are useful diagnostic features. Should pregnancy follow, the tumour may 880 A MANUAL OF SURGERY increase in size at an alarming rate. In the infiltrating forms it is almost impossible to distinguish it from encephaloid cancer, except on microscopic examination, (b) A spindle-celled sarcoma, or fibro-sarcoma, is also met with, forming a rounded or oval tumour, more limited than the above, and growing somewhat less rapidly. It somewhat simulates an adenoma, but is more closely connected with the breast substance. The axillary glands are but rarely involved, and the sarcomatous nature is recognised by the microscope and by the great tendency of the growth to recur even after apparently complete removal ; on account of this latter feature, the name of 'recurrent fibroid tumour' (Paget) was formerly applied to it. The recurrences generally take place at gradually diminishing intervals, and the tumour may then become softer and more vascular ; occasionally the tendency to recur seems to wear itself out after the performance of several operations. The Treatment of sarcoma mammae consists in the removal of the entire organ at as early a date as possible, together with the axillary glands. Cancer of the Breast. No organ of the body, with the exception of the uterus, is more frequently the seat of cancer than the female breast : it also occurs in the male subject, but is about a hundred times less common than in the other sex. etiology. — The breast is an organ subject to great changes in functional activity, richly supplied with blood, and closely associated by nervous connections with other organs of the body, especially the uterus. At the climacteric its functions are at an end, and as it always undergoes a certain amount of fibrosis or degeneration, it can be readily understood that changes are very likely to ensue which may result in the formation of a cancerous tumour. Such is usually met with after the age of forty, although the disease may prove fatal at a much earlier date. It equally affects women who have borne children and nulliparae, and the question whether or not the woman has nursed her children seems to have but little influence. The left breast is more often affected than the right. It is frequently attributed to some injury, such as a blow or squeeze ; whilst there is little doubt that badly-fitting stays are responsible for a certain per- centage of the cases. It not uncommonly follows eczema of the nipple, especially that variety known as Paget's eczema ; chronic interstitial mastitis may also possibly be an occasional precursor of this affection. The question as to heredity is one exceedingly difficult to decide, and, although it may be a marked feature of some cases, it is somewhat doubtful whether, as a general rule, it has any considerable influence. Two distinct types of cancer are met with in the breast — viz., acinous or glandular cancer (including scirrhus and encephaloid), DISEASES OF THE BREAST and duct cancer. Colloid degeneration of either of the former varieties has been observed, but is very uncommon. i. Acinous Cancer is the form almost invariably seen; the division into scirrhus and encephaloid is entirely artificial, depending on the greater or less amount of fibrous stroma present in any particular case. Scirrhus usually commences as a hard circumscribed mass, situated most commonly in the outer half of the organ. It is closely united to, if not absolutely incorporated with, the breast substance, and on careful digital examination its margin is not so accurately defined as at first appears. In the early stages it is entirely distinct from the skin, which moves freely over its surface ; but as growth proceeds, the stroma contracts, and, by dragging on the suspensory ligaments passing from the mamma to the skin, the latter structure becomes more or less fixed, and hence, on attempting to move it upon the tumour, an appearance of dimpling results. At the same time, the whole breast is acted upon in a similar manner, so that the affected organ often seems to be smaller than the other ; and, since the upper half of the gland is usually affected, the nipple may be drawn up so as to lie at a higher level than its fellow, as well as being retracted from the tractionof the growth on the galactophorous ducts (Fig. 315). The tumour itself is rarely one of great size, so long as it retains its scirrhous nature ; it is sometimes extremely painful and tender, but not uncommonly the pain is intermittent, and of a neuralgic type, extending to the shoulder, and perhaps only elicited on mani- pulation. As the growth increases in size, it becomes adherent to the pectoral fascia, and may even infiltrate the underlying muscular substance, so that, on examination, with the arm extended and abducted, it is found that, although moveable across the fibres of the muscle, the breast cannot be moved with them. The lymphatic glands in the axilla soon become enlarged, the disease rarely lasting many months without this complication. Those running with the long thoracic vessels under cover of the pectoralis major are first involved, and, as the case progresses, the remaining axillary and subscapular sets become similarly affected, and even after a time the supraclavicular. When the deeper part of the breast is attacked, the disease may spread to the mediastinal glands along the lymphatics, which accompany the nutrient vessels arising from the internal mammary trunk ; and thus intrathoracic deposits develop, which even extend along the subpleural connective tissue, and affect the pleural cavity and lungs. In those cases where the primary growth is situated near the inner border of the breast, the free lymphatic anastomosis across the middle line allows of the transmission of the disease to the glands in the opposite axilla, and sometimes a similar affection of the opposite breast arises from this cause. The skin may be implicated in many ways, (a) We have already 56 S82 A MANUAL OF SURGERY mentioned the dimpling which is met with over the tumour in the early stages. As the case proceeds, the cancer extends outwards along the suspensory bands of fascia, so that the skin itself becomes invaded, feeling firm and brawny, and looking congested and purplish in colour, whilst a branny desquamation is usually present. A crack or fissure at length forms, giving exit to a little serous discharge, which at first scabs over, but finally leaves an ulcerated surface, which slowly extends, and may attain considerable dimen- Fig. 315. — Scirrhus Mammae. (From a Photograph.) The patient had allowed the tumour to grow for two years. The whole of the left breast was infiltrated and raised above the level of the other organ ; the nipple was retracted. sions. A typical scirrhous ulcer is hollowed out and excavated ; its surface, if kept clean, is covered with smooth granulations, dis- charging a considerable amount of sanious fluid, but if neglected, it becomes sloughy and offensive ; it is surrounded by a projecting elevation of the tumour substance, forming a sort of rampart around it. (b) Less commonly the disease becomes disseminated through the skin, giving rise to a series of dusky-red, button-like masses of cancer, surrounded by skin which is often apparently unaffected ; DISEASES OF THE BREAST or the whole cutaneous surface of the organ may become infiltrated and thickened, constituting the condition known as cancer en cuirasse. In the earlier stages the skin is thickened and firmer than usual ; but the mouths of the sebaceous glands are enlarged and very evident, giving it a coarse appearance like 'pig-skin,' or the rind of an orange (pcau cT orange of French authors). Later the colour becomes dusky, and the skin so contracted and indurated that it is impossible to wrinkle it ; the sebaceous glands may Fig. 316. — Side View of the same Breast as in Fig. 315. The retracted nipple is well seen, as also the commencing infiltration of the skin towards the axilla, whilst the lineae albicantes are also infiltrated and swollen. exude an abundant secretion, which becomes inspissated on the surface into crusts or scabs, which are independent of any ulcera- tion. This process often extends widely beyond the limits of the breast, invading the whole thoracic wall, and even running over the shoulder to the back of the head or neck ; it is due to a diffuse extension of the disease along the cutaneous lymphatics, and in its most typical form is slow in its development, the patient perhaps living for many years. Localized buttons or nodules of 56—2 A MANUAL OF SURGERY cancer are often found scattered through the affected area. (c) Occasionally one meets with a much more rapid form of cancerous lymphangitis, in which the skin becomes similarly affected, but the growth is not unfrequently associated with what is supposed to be a ' weeping ' eczema, due in reality to the yielding of dilated lymphatics, that can be easily seen on examining with a lens. The process spreads widely and rapidly, and cancerous nodules appear here and there in the infiltrated area ; the prognosis is of course very grave. In the later stages, the patient passes into a state of cachexia, becoming emaciated and exhausted. Ulcerated surfaces of con- siderable size may exist, and the tumour is fixed to the thoracic wall, even invading the ribs. The arm on the affected side is swollen and brawny, owing to the pressure of the enlarged glands on the main lymphatics and veins of the limb, constituting a condition of lymphatic or solid oedema. Secondary deposits also develop in the viscera, and may lead to various symptoms, according to the situations in which they are placed. Finally, death from exhaustion ends the scene. Encephaloid or Acute Cancer occurs less frequently as a some- what soft, rapidly-growing tumour, which quickly infiltrates the whole organ, and gives rise to secondary lymphatic and visceral affections at a much earlier date than scirrhus. It does not tend to cause retraction of the nipple or dimpling of the skin, the latter structure being distended, and with blue veins coursing under it. The breast becomes enlarged and prominent, the skin is gradually invaded by the tumour, ulceration follows, and a foul fungating mass sooner or later sprouts up through the opening. The cancer that attacks young women is often of this type, and the prognosis necessarily very grave. Finally, in elderly women, a chronic form of cancer is met with, known as Atrophic Scirrhus, in which the disease lasts for many years without much definite extension. Cases have been known to persist for fifteen or twenty years, the patient at length dying of some intercurrent malady, although in the great majority dissemination has ultimately occurred. The special characters are due to the excessive contraction of the stroma, as a result of which the cellular elements become crushed and practically destroyed. The nipple is deeply retracted, and the tumour and breast substance in the most marked cases are scarcely discernible. 2. Duct Cancer is a somewhat rare form of the disease, the exact nature of which is still under discussion, and there is very little doubt that several distinct types have been described under this name. It is sometimes characterized by the development of one or more nodules of a malignant papillomatous nature within the dilated ducts, and usually situated not far from the nipple. These growths are covered with columnar epithelium, and may, DISEASES OF THE BREAST 885 indeed, be looked upon as forms of columnar cancer. They are exceedingly vascular, and a blood-stained discharge from the nipple is usual. They always grow slowly, and when situated near the skin give rise to a round dusky-red swelling. The nipple is not retracted, and lymphatic enlargement not constant. In other cases the dilated alveoli are occupied by masses of pro- liferated epithelial cells of a spheroidal type, which arrange themselves into more or less definite papillomatous growths, whilst cystic degeneration also occurs. Either of these varieties may be associated with a development of ordinary scirrhus in some other part of the breast. The diagnosis can only be established with certainty by microscopic examination after removal. The duration of cancer varies considerably in the different forms. The encephaloid type runs a rapid course, and will probably destroy the patient's life in six to twelve months. Duct cancer is very slightly malignant, whilst atrophic scirrhus is similarly slow in growth, and in both death may be postponed for a con- siderable period, or is often due to some intercurrent malady. Cancer en cuirasse is variable in its course, being sometimes tolerably rapid, and at others chronic ; it cannot be cured by operation, on account of its early and extensive dissemination. A circumscribed scirrhous tumour is stated to end fatally, on an average, in two or three years if no operative treatment is under- taken, whilst removal of the mass will probably add another year or eighteen months to the patient's life. These figures are, however, derived from statistics of operations performed before the general adoption of the more exact and extensive measures which are now usually undertaken, and it is likely that they considerably under-estimate the benefits derived from such interference. The Pathological Anatomy of cancer is discussed in Chapter VII. The Diagnosis of scirrhus from chronic interstitial mastitis and chronic abscess or cyst has been already considered (p. 871). From tumours of the adenoid type it is easily distinguished. The stony hardness of a scirrhus, its union with the breast substance, its limited mobility, the dimpling of the skin, retraction of the nipple, and enlargement of the axillary glands, are the chief local charac- teristics to be noted. Non-malignant tumours are more elastic to the touch, more moveable, and usually quite circumscribed in outline, whilst the skin, though expanded, does not become adherent ; the nipple is rarely retracted, and the axillary glands remain of normal size. It is often impossible to distinguish a cancerous from a sarcomatous tumour, except on microscopic examina- tion ; a round-celled sarcoma closely resembles an encephaloid cancer, although it is usually more circumscribed — at any rate, in the early stages. The fibro-sarcoma may sometimes be mis- taken for scirrhus, but it is more defined in outline, does not cause retraction of the nipple or dimpling of the skin, whilst lymphatic SSf, A MANUAL OF SURGERY enlargement is not a constant accompaniment. A cysto -adenoma presents no difficulty in diagnosis if the skin is entire, and the cysts prominent ; but when ulceration has taken place, and a fungating bleeding mass protrudes, it is not unlike the later stage of an encephaloid cancer or fungating round-celled sarcoma. It can be distinguished, however, by the fact that a probe can some- times be passed under the skin for some distance into the cavity of the cyst, whilst lymphatic enlargement is rare. Treatment. — This necessarily consists in the removal of the tumour by operation ; but in order to give the patient as good a chance as possible of a permanent cure, the excision must include the whole of the breast, the greater portion of the overlying integument, the subjacent pectoral fascia, possibly a part of the pectoral muscle, and the whole of the lymphatic and connective tissues of the axilla. A full description of the operation is given below, but we desire here to emphasize the fact that the pro- ceeding should be very radical if the patient is to derive any real benefit from it. In the old days, only the more prominent portion of the breast was removed with the tumour, and consequently recurrence was so exceedingly common that if 5 or 10 per cent, of the patients were really cured, it was thought to be as much as any surgeon could reasonably expect. Since we have learnt more of the anatomy of the organ and of the pathogenesis of the disease (for which we are mainly indebted to Heidenhain and Stiles), more extensive proceedings have been undertaken, with a gradual amelioration in the results, so that several surgeons have been able to report 50 to 60 per cent, of their cases as free from recur- rence at the end of three years. It was suggested by Volkmann that any case that remains free from recurrence for three years may be claimed as a cure, but this is generally considered too short a period on which to base such an assumption, since experi- ence tells us that the disease often reappears at a much later date (even nine or ten years). It has been proved that the breast is a much more extensive organ than was formerly supposed, and if merely the projecting portion is removed, many deep lobules are left, which may lead to recurrence. Moreover, it has been shown that the deeper lymphatics pass into the fascia covering the pectoralis major, and so to the axilla ; hence, this structure should always be taken away, as well as a thin layer of the muscular fibres in certain cases. Again, lymphatics travel along the fibrous bands reach- ing from the breast tissue to the overlying skin, and thus this latter must never be dissected back from over, the tumour. The nipple should under no circumstances be left behind, since all the interlobular lymphatics converge to a plexus around it, and reach the axilla by three or four main trunks. The axilla itself should be opened in every case, and entirely cleared of its lym- phatic contents, since deposits in the glands are often found on DISEASES OF THE BREAST 887 microscopic examination, where no clinical evidence of their presence had been previously noted. It is also important to remove the breast and axillary tissues in one piece, so as to avoid division of the lymphatics and possible infection of the wound with their cancerous contents. Of late years Halsted of Baltimore has been urging the neces- sity of removing the pectoral muscles with the breast in all cases of cancer, in order to gain better access to the axilla, and also to ensure the extirpation of the lymphatics which pass between or through them. This is often termed the complete operation, and is being largely employed. The clavicular portion of the great pectoral is left, the sternal portion being removed from within outwards, and the tendon divided close to the humerus. Whilst admitting that this practice is good and desirable in cases where the muscle is involved, or where there is much axillary infection, we scarcely consider it necessary as a routine procedure. As to the cases in which operation should or should not be undertaken, the following facts must be noted : Cancer en cuivassc should never be touched, since it is impossible to eradicate the disease, owing to its wide dissemination through the cutaneous lymphatics. Atrophic scirrhus also is often left alone, on the plea that the prognosis is so favourable as to render operation unnecessary ; if, however, the patient is fairly strong, there is no objection to it, and it certainly seems wise to remove a cancerous focus, however chronic it be. Apart from these, all cases in which there is a reasonable prospect of eradicating the disease may be subjected to operation. The following grave conditions, however, require the most serious consideration : (i.) Where the supraclavicular glands are enlarged, it seems hopeless to expect that the whole disease can be eliminated, and yet one likes to give the patient her only chance. The operation must then include the supraclavicular fossa in its scope, as recommended by Halsted ; he indeed goes so far as to maintain that the posterior triangle should be cleared of its lymphatic contents in all cases, whether or not enlarged glands can be detected beforehand, and states that in a considerable percentage of cases cancerous invasion will have already occurred. The cervical incision is a curved one, extend- ing along the posterior border of the sterno-mastoid, and outwards along the clavicle. This flap is dissected up, and all the fat and glands are removed from before backwards, the internal jugular vein being the starting-point. Of course, the greatest care is taken to avoid the thoracic duct or right lymphatic trunk, (ii.) If the tumour is adherent to the thoracic parietes, no opera- tive interference is advisable, (iii.) Evidence of pressure on, or implication of, the axillary nerves also precludes such treatment ; slight oedema of the arm due to pressure on the main vein need not deter the surgeon from proceeding, since the whole vein has been successfully excised ; in such cases the collateral circulation 888 A MANUAL OF SURGERY has evidently been opened up previously, (iv.) Profound cachexia and evidence of visceral deposits also contra-indicate operation, except to give relief to the local pain, (v.) Extensive ulceration and fungation, and general diffusion of the tumour through the breast, are, as a rule, prohibitory signs, (vi.) Disease of both breasts, although rendering the prognosis more grave, is, ceteris paribus, no hindrance, since both organs have been removed suc- cessfully, even at one operation. Speaking generally, rapidly- growing tumours in vigorous patients are exceedingly unfavourable cases to deal with, whilst slow growth of the tumour, and definite limitation of its outline, are favourable signs. Amputation of the Breast is an operation which is performed not only for the removal of cancerous or sarcomatous growths, Fig. 317. — Incisions for Amputation of the Breast in Cancer. but also for diffuse hypertrophy, for diffuse septic or tuberculous disease when the organ is riddled with sinuses, and occasionally for interstitial mastitis. The proceeding is a very simple one in non-malignant cases. The incisions usually employed are semi- lunar, and placed obliquely, as on the right side in Fig. 317; in simple cases, however, there is no need to include so much of the integument. The skin is dissected up on either side from the glandular tissue, and the organ freed from its attachments to the pectoral fascia ; the axilla need not be opened. Operation for Cancer. — The patient lies on the back, with the head directed towards the opposite side, and the arm raised, so as to put the pectoralis on the stretch. An aseptic towel should be wrapped round the head, so as to keep the hair out of the way, and a similar carbolized towel may be placed below the chin, to DISEASES OF THE BREAST form a barrier between the anaesthetist with his apparatus and the field of operation. The axilla should be previously shaved, and the skin carefully purified. The incisions employed vary with the size and position of the tumour, one great essential being that no portion of skin which lies immediately over the tumour should be left ; where it is located in the outer and upper quadrant, as is so commonly the case, incisions somewhat similar to those repre- sented in Fig. 317 (right side) will do very well. In other cases the incisions may be placed horizontally, extending backwards as far as the posterior axillary fold, and then the axilla is dealt with through a vertical incision running up along its anterior border (Fig. 317, left breast). It is the usual custom to make the lower incision first, so that the view of the surgeon may not be inter- fered with by the blood trickling from the upper wound, but this is by no means essential or always convenient. The skin is dis- sected back on either side from the glandular substance, keeping well clear of breast tissue. The inner side is then dealt with first, the wound being carried down until the pectoral is exposed, and the gland, together with the deep fascia, dissected off the muscle from within outwards until its outer border is reached. It is always wise to remove the superficial layer of muscle fibres, even if one does not go further. Attachment to or infiltration of the muscle, of course, involves the removal of a considerable portion of its substance. During this stage of the operation all bleeding- points are secured temporarily by Spencer-Wells' forceps. The breast, together with the fascia, and perhaps part of the muscle, is now lying turned outwards, merely connected to the trunk by its axillary attachments. The surgeon then carries on the dis- section along the under surface of the pectoral muscles, opening up freely the axillary cavity, and if need be increasing the cutane- ous incision for this purpose. The axillary vessels are first cleaned, the vein often coming prominently into view. The apex of the space is then dealt with, all lymphoid tissue and fat being removed, and finally the inner and posterior walls are similarly treated, until when the dissection is complete nothing remains within the cavity but the main vessels and nerves ; whenever possible, the sub- scapular branches should be spared. When the complete operation is undertaken, the skin is dis- sected back from the incisions beyond the extreme limits of the breast. The division between the sternal and clavicular por- tions of the pectoralis major is then opened up along its whole length, and its insertion divided about an inch from the humerus; the finger is then passed under its sternal origin from above down- wards, so as to raise it from the underlying structures and allow of its division with the knife. The pectoralis minor next comes into view, and is divided at its costal attachments, and also close to the coracoid process. The finger next sweeps down the outer surface of the serratus magnus (sparing the nerve of Bell), detach- 890 A MANUAL OF SURGERY ing the axillary fat from it, and then the main axillary vessels and nerves are dissected out. Finally, the subscapularis is cleared from above downwards, and the whole mass, including breast, pectoralis, and axillary contents, is freed from its attachments to skin and muscles on the outer side. Having thus, it is hoped, eliminated the disease, all bleeding- points are ligatured, the wound is closed by a continuous suture, aided by one or two deep tension stitches, and a drainage-tube is usually inserted for a day or two ; it may be placed with advantage through a special opening made in the posterior axillary wall. Where much skin has been removed, there will be some difficulty in bringing the edges of the incision together, but by judicious undercutting and sliding an open wound can usually be avoided. If, however, it cannot be closed, skin-grafting by Thiersch's method must be resorted to. The immediate results of this operation are exceedingly satis"- factory, the mortality being slight, probably not 5 per cent. Patients often used to complain of impairment in the movements of the arm when the axilla had been opened and the wound allowed to heal with the arm fixed to the side ; this is entirely obviated by keeping the arm away from the side at right angles to the body. Healing is assisted by this position, since drainage is facilitated and better pressure can be exerted upon the wound, and there is consequently less oozing. Even when the pectorals have been sacrificed, the patient is still able to lift the arm to the back of the head, and the movements of the limb seem but little impaired. The final results necessarily vary with the period at which operation was undertaken, and with the care and skill of the surgeon. Local recurrence after operation is always due to incomplete re- moval of the growth, or to infection of the wound during the operation. The operator must ever keep in mind that although in a healthy organism the implantation of cancerous material has apparently but little or no effect, yet in a cancerous individual positive results are only too certainly obtained. The recurrence appears either in the neighbourhood of the cicatrix, the most usual situation, or in adjacent lymphatic glands. The progress is often slow, but occasionally the disease spreads more rapidly than if no operation had been undertaken. Another attempt should always be made to remove the growth, if such be feasible. Recently a proposal has been made by Beatson of Glasgow to deal with inoperable cases of cancer by oophorectomy, com- bined with the administration of thyroid extract, and two or three cases of apparent recovery under this regime have been recorded. Certainly, if the patient is made to fully understand what is involved by such a proceeding, there can be no objection to trying it, although our present experience seems to indicate that the improvement, often unquestionable at first, is only temporary. CHAPTER XXXII. ABDOMINAL SURGERY. Injuries of the Abdominal Walls. These may be divided into three main classes — contusions, non- penetrating and penetrating wounds. Contusions of the abdominal walls vary in their results with the cause and character of the injury, and with the condition of the subjacent viscera. If due to a slight blow, the effects are probably not serious, the patient merely suffering from pain and bruising, as in any other part of the body. If the blow, although slight, falls upon a distended viscus, such as the stomach or bladder, the organ may be torn, and the contents extravasated into the abdominal cavity, with fatal results from peritonitis. If a solid viscus, such as the liver or spleen, is injured, alarming haemorrhage may occur into the peritoneal cavity, from which the patient may die. An account of these visceral injuries is given seriatim under the appropriate headings in this chapter. Any sudden sharp concussion, especially if directed to the epigastrium, is liable to be followed by severe shock from irritation of the subjacent solar plexus of the sympathetic nerves, and life itself may be destroyed in this way by syncope without the appearance of an evident lesion. If the injury is limited to the abdominal walls, rupture of one or more of the constituent muscles, especially the rectus, may occur. A haematoma of considerable size usually follows, and this is especially liable to suppuration and the formation of an abscess, which may point directly at the injured spot, or burrow widely between the muscular planes. The smell of the pus is always suggestive of the presence of the Bac. coli, and this organism probably finds its way into the extravasated blood from some slightly damaged coil of intestine in the neighbourhood. As a further complication, laceration of the parietal peritoneum may be mentioned, causing shock and intraperitoneal extravasation of blood ; if the latter is abundant, as from a large vessel, peritonitis is almost certain to follow. 892 A MANUAL OF SURGERY The Treatment of an abdominal contusion is always a matter of some anxiety to the surgeon, as it is difficult at first to make certain of the exact nature of the injury, and as to whether or not visceral complications are present. In the more simple cases all that is needed is to put the patient to bed, combating shock in the usual way by the application of warmth, but stimulants should be avoided, if possible, for fear of restarting haemorrhage. In the more severe cases, a decision has to be made as to whether expectant treatment is to be depended on, or whether an explora- tory laparotomy is to be undertaken. No absolute rules can be laid down as to when operation is necessary, but the surgeon should remember that exploration in a doubtful case will probably do far less harm than delaying operation until the diagnosis is made certain by an outbreak of diffuse inflammation, providing always that the patient is not so profoundly collapsed as to contra- indicate all interference. The examination of the abdomen and of the patient may bring to light facts which make operation essen- tial, such as (a) severe intraperitoneal haemorrhage, (b) general tympanites or free gas in the peritoneal cavity, as indicated by loss of the area of hepatic dulness, (c) blood-stained vomiting, or (d) the phenomena due to a lacerated bladder. Under such circum- stances, no delay is justifiable, and, even if severe shock is present, operation should be commenced, unless death is evidently imminent. A large intravenous injection of hot saline solution will usually rally the patient sufficiently to warrant the surgeon in proceeding, whilst freely washing out the peritoneal cavity with the same hot solution has often a similar effect. If, however, well-marked shock is present, with perhaps localized pain, but with no absolute evidence of visceral lesions, expectant treatment should be adopted. The patient is kept warm in bed ; perhaps a little opium is administered to allay pain and restlessness and to check peristalsis, but as little as possible should be given, since symptoms are so completely masked thereby. If there is any vomiting, rectal alimentation should be employed after the lower bowel has been washed out. If, at the end of twenty-four hours, the patient is still in a condition of collapse, and especially if manifestations of intraperitoneal haemorrhage or of commencing peritonitis have made themselves evident, operation can still be undertaken with some prospect of success. Non-Penetrating Wounds of the Abdominal Wall do not demand separate attention, since there is no special significance about them, and if uncomplicated by contusions are treated on general principles. If the epigastric artery is divided, extensive extrava- sation is likely to ensue ; the wound must then be enlarged, and the bleeding-points secured. It must also be remembered that the sheath of the rectus is divided anteriorly by the lineae transversae into separate compartments ; but as these do not extend through the whole thickness of the muscle, collections of ABDOMINAL SURGERY S93 blood or pus may be limited anteriorly, whilst behind they become diffuse. If the abdominal muscles are widely divided, steps should be taken, after thorough purification, to draw together the severed muscular or aponeurotic fibres by deep stitches, so as to diminish the tendency to a ventral hernia. Penetrating "Wounds of the Abdominal Wall may occur with or without injury or protrusion of the abdominal viscera. In all cases there is a certain amount of haemorrhage, greater or less according to the size of the vessels divided, and of shock, which latter is very marked when the viscera are injured, whilst mere protrusion without injury may cause but little effect. Thus, cases are on record in which a patient has walked to the surgeon for treatment, supporting some coils of intestine in his hands. The protruded viscera, usually small intestine or omentum, are often large in amount compared with the size of the opening, causing them to be more or less congested, or even strangled. Neces- sarily, in all cases the great danger is that of diffuse septic peritonitis, caused either by rupture of the intestine or by infection from without. It is an interesting point to note that the peritoneum that covers the viscera has but little sensation of pain, whilst the parietal peritoneum and that forming the mesentery are very sensitive ; on the other hand, the visceral peritoneum is much more liable to bacillary invasion. The Treatment of these abdominal wounds has been entirely altered in recent years, as a result of increased confidence in antiseptic methods. The external wound is carefully cleansed, whilst protruding viscera are similarly purified. If omentum has escaped, it is wise to ligature and remove it, whether it is injured or not. Intestine should be carefully washed with warm saline solution, or with weak antiseptic lotions, such as boric acid lotion, or sublimate (1 in 4,000), and then replaced ; if slightly bruised, it may be returned, but the external wound should not be entirely closed and a drainage wick of gauze inserted, so that if faecal extra- vasation occurs a ready exit is provided. Small incisions or punc- tures must be sutured, but when intestine is hopelessly damaged, enterectomy should be undertaken if the patient's general con- dition is sufficiently good ; but if unfit to undergo such an opera- tion, the gut must be fixed in the wound as in colotomy, and the defect dealt with at a subsequent period. In cases where it is not certain whether the peritoneum has been implicated, the surgeon should always enlarge the wound so as to make sure, and if the serous membrane has been involved, he should carry his investigations still further, and ascertain, if possible, whether any damage had been done to the viscera. The external wound must (with the exception mentioned above) be carefully closed with sutures, so as to minimize the risk of a subsequent ventral hernia. The peritoneum and divided muscles are united by buried stitches of catgut or well-boiled silk, and 894 A MANUAL OF SURGERY finally the skin is brought together with a continuous suture. A drain-tube may need to be inserted for a time. There are but few other conditions of the abdominal wall which require notice. The rectus muscle may be torn as a result of injury or tetanic convulsions, and a hernia is very likely to follow. One of the segments may become spasmodically contracted, constituting what is known as a ' phantom tumour,' usually occurring in hysterical females, and disappearing under an anaes- thetic. Affections of the Umbilicus. The various forms of umbilical hernia are described at p. 991. Inflammation and Ulceration, perhaps running on to eczema, may arise from want of cleanliness after separation of the cord. Tetanus neonatorum probably owes its infection to this source, as also the erysipelas of infants, both of which diseases are ex- ceedingly fatal, whilst the latter is often accompanied by sloughing of the neighbouring abdominal parietes. The eczematous con- dition merely requires cleanliness, and the application either of an antiseptic dusting-powder or of some simple ointment. Occasionally a Polypoid Excrescence is met with growing from the umbilicus, and is probably derived from the remains of the umbilical vesicle. On microscopic examination, it is found to consist of a number of tubular glands held together by connective tissue. All that is required is to ligature the base and cut it away. Warts and Nsevi are also found here, but need no special notice, as also syphilitic and epitheliomatous disease. Umbilical Fistulae not unfrequently occur, and may be congenital or acquired. Three varieties are described : (a) A Fecal Fistula of congenital origin arises from non-closure of the vitello-intestinal duct, and either opens into the intestine directly, or by means of a passage of greater or less length, which corresponds to Meckel's diverticulum, and is connected with the lower part of the ileum. Acquired cases are usually due to per- foration of the bowel following strangulation of an umbilical hernia, or to tuberculous peritonitis. (b) A Congenital Urinary Fistula is due to non-closure of the urachus ; occasionally merely a sinus persists, leading towards the bladder, but not opening into it. It may be dealt with by excision of the mucous membrane, its destruction by the galvano-cautery, or by freshening the edges and subsequent suture. (c) A Biliary Fistula sometimes forms at the umbilicus, resulting from an abscess connected with the gall-bladder. In Ectopia Vesicae the umbilicus is absent, the extroverted portion of the bladder extending up to what should normally be its situation. ABDOMINAL SURGERY 895 Affections of the Peritoneum. Inflammation of the peritoneum, or Peritonitis, arises from a variety of conditions, and presents many diverse manifestations. It is a disease which may be limited to some particular locality, or may involve the whole serous membrane. In discussing the subject, we shall avail ourselves of the large mass of information gathered together by Sir Frederick Treves in the Lettsomian Lectures for 1894. From an etiological point of view, it may be stated that peri- tonitis is almost invariably due to the action of micro-organisms, the symptoms being largely those of toxic poisoning, death, when it occurs, resulting from toxaemia rather than from the inflammation. The following forms may be distinguished : 1. Peritonitis due to infection from the intestine, the organism usually present being the Bacillus coli communis. Entrance to the peritoneal cavity may be gained either through some actual breach of surface, such as a penetrating wound or perforating ulcer, or through an intestinal wall, the resisting powers of which have been diminished by inflammation or injury. The peritonitis associated with appendicitis, or secondary to strangulated hernia, is of this type. 2. Peritonitis due to infection from without, the ordinary pyogenic organisms being present, especially the Streptococcus pyogenes. This variety occurs in penetrating or operation wounds where the bowel is uninjured, as also in puerperal peritonitis. 3. Peritonitis may be due to the gonococcus, which has travelled up the Fallopian tube from the vagina. 4. Tuberculous peritonitis also occurs, and is usually chronic in type. 5. There is a group of cases in which peritonitis is of doubtful origin, possibly arising from chemical or local irritants, rheumatism, etc. ; but it is still a moot point whether such can be caused apart from the activity of micro-organisms. Clinical History. —From a purely clinical standpoint, peritonitis may be discussed under two main headings — the acute and the chronic. The acute is again divided into the diffuse and localized, and the chronic into the simple and the tuberculous. Acute Diffuse Peritonitis. — The onset varies somewhat with the cause of the affection ; but when due to traumatic infection from without, the symptoms usually commence with abdominal pain and distension, together with flatulence and vomiting. The pain may at first be localized to some particular region, or referred to the umbilicus ; it soon, however, becomes diffuse, and is associated with exquisite tenderness and great distension. In a typical case the phenomena are very characteristic. The patient 896 A MANUAL OF SURGERY lies on his hack with the knees drawn up, partly to relax the abdominal muscles, partly to prevent the bedclothes touching the body. The abdomen is distended, hard, and extremely tender ; it is at first generally tympanitic, but later on, if effusion should become marked, dulness may be noted in the flanks, although this is not a common feature. The pulse is quick, hard, and wiry in the early stages, though later it becomes weak, rapid, and com- pressible. The respirations are quick, shallow, and thoracic in character. The temperature, raised at first, tends to become subnormal from toxaemia before the end is reached. Vomiting is usually a prominent symptom, associated perhaps with hiccough ; to commence with, the contents of the stomach alone are expelled, but later on they may be mixed with bile, or even faecal material. Though very constant and troublesome, it is much less distressing than that which arises from intestinal obstruction, and, owing to the pain induced by any sudden contraction of the abdominal muscles, the patient ejects the vomit with but little force. Con- stipation and arrest of flatus are always present in peritonitis, owing to the cessation of peristalsis induced by the inflammation. As the case progresses, the patient's strength rapidly diminishes, his face becomes pinched and drawn (fades Hippocratica), the extremities are cold, the temperature is usually subnormal, and death results from collapse and toxaemia. When due to sudden perforation of the bowel, the onset of the symptoms is associated with profound shock, and the course is very rapid if the opening is large, and the intestinal contents early extravasated. Vomiting, too, is usually more marked than when due to other causes. If, however, the perforation is small, the immediate shock is less, and the symptoms progress more gradually. The Post-mortem Phenomena of acute diffuse peritonitis consist in an exudation into the peritoneal cavity of turbid serum or pus, mixed with flocculi of lymph. The serous coat of the intestine is roughened, and adjacent coils may be matted together by greenish semi-puriform lymph. The effusion is mainly found in the pelvis and lower part of the abdominal cavity, and is not always very abundant ; it is intensely infective, and any wounds caused during the performance of the post-mortem examina- tion are likely to be followed by severe cellulitis or even fatal septicaemia. The omentum sometimes forms a barrier shutting off the lower from the upper portion of the peritoneal cavity, and limiting the mischief to one or other section. Treatment of Acute Diffuse Peritonitis. — In former days treat- ment consisted in fomenting the abdomen, and keeping the patient fully under the influence of opium, whilst abstinence from food was enforced, and possibly calomel given as an absorbent ; but since peritonitis is very rarely idiopathic in nature, and usually results from some very definite local lesion, such measures are ABDOMINAL SURGERY 897 rarely adequate. In diffuse peritonitis, expectant treatment of this character is almost certain to be followed by a fatal issue ; and although treatment by operation has no great results to boast of, it is the only rational plan to adopt. The virulent nature of the toxins produced by the inflammatory process, and the late date at which operation is usually performed, fully suffice to explain the high death-rate associated with it. An exploratory laparotomy should therefore be undertaken as early as possible, the incision being made in the linea alba, and usually below the umbilicus, unless there is tolerably clear evidence that the causative lesion is in the upper part of the abdomen. The effusion is allowed to escape, and by gently separating the coils of intestine localized pockets of fluid may be evacuated. Collections of blood or pus should be swabbed out by gentle sponging, or possibly general irrigation of the abdominal cavity with sterilized salt solution (o*6 per cent.) may be adopted. In this proceeding care must be taken to maintain the fluid at a constant temperature (105 to 1 io° F.), to prevent abdominal distension, and not to allow the fluid to play on the under surface of the diaphragm for fear of causing respiratory embarrassment. If the original lesion can be reached without much difficulty, it must be dealt with according to the rules given hereafter, provided that the patient's general condition is sufficiently satisfactory. Drainage of the peritoneal cavity by a glass drainage-tube, or perhaps better by strips of gauze passed amongst the intestines in different directions, is usually essential. In cases of threatening peritonitis following abdominal opera- tions, as indicated by pain, distension and vomiting (peritonism), the chief causative factor is often a paralytic condition of the gut, which permits of the retention and decomposition of the intestinal contents, thus assisting the activity of the Bac. coli. In such cases a smart saline purgative (e.g., sodii sulphas, gr. xx.-xxx., every hour) is often useful, in order to free the intestine from its irritating contents. When, however, general septic peritonitis is present, purgatives can only do harm. Acute Localized Peritonitis usually arises in connection with some limited lesion of the abdominal contents, which is of such a nature as to permit of the general peritoneal cavity being shut off by adhesions between adjacent coils of intestine, the process being thereby localized. It is usually, although not invariably, followed by suppuration, the abscess being thus intraperitoneal, although not involving the general peritoneal cavity. The abscesses arising in connection with appendicitis or pelvic peri- tonitis are not uncommonly of this nature. They may burst through the barrier of adhesions, and thus light up a diffuse in- flammation of the peritoneal sac, or they may burrow to the surface and burst, or open into one of the hollow viscera. The Symptoms complained of are deep pain and tenderness, more or less localized to the affected area, together with fever, 57 .J MANUAL OF SURGERY vomiting, and constipation. At first no swelling or tumour is to he made out, but a feeling of resistance may be noticed in the abdominal wall, which is held tense and rigid, as if guarding some focal point of mischief. As the effusion increases in amount, a tumour dull or tympanitic on percussion usually becomes evident ; it is mainly due to a matting together of the intestines, but associated with a variable amount of effusion. If the abscess travels towards the surface, the abdominal wall becomes infiltrated, red, and cedematous, the component tissues being brawny to the touch, and cutting like bacon. Finally, a fluctuating area presents itself in the midst of this indurated mass, and the abscess either discharges itself or is opened. The pus contained therein may be thin and offensive, or it may be free from odour, and then is often somewhat inspissated, and like custard in consistency. Of course this process is attended with con- siderable increase in the pain and constitutional disturbance. If the cavity is treated antiseptically, it rapidly contracts and a cure is accomplished, although intraperitoneal adhesions may persist and lead to trouble later on from hampering the intestinal move- ments. If a communication is established with the intestine, a faecal fistula is very apt to follow ; whilst if the cavity becomes septic, chronic suppuration may result, and thereby the patient's health and strength are undermined. Treatment of Acute Localized Peritonitis. — In these cases, resolution can be obtained in favourable cases by keeping the patient quiet and on a low diet, with perhaps a little morphia, and by applying fomentations locally, whilst the lower bowel is emptied by an enema. Such a course must, however, not be per- sisted in for too long when suppuration is likely to have occurred, for fear of the inflammation spreading to the general peritoneal cavity, or of the abscess bursting into it. An early exploratory laparotomy is advisable under such circumstances. The line of treatment marked out for appendicitis (p. 950) is that which should always be followed. Simple Chronic Peritonitis in itself rarely requires surgical attention, since it is to be looked on rather as a protective than as a destructive process. It is characterized by infiltration and thickening of the peritoneum, giving rise to adhesions, whereby the intestinal wall is strengthened, and bacterial invasion limited. It is localized or diffuse in character, and arises either as a result of pre-existing acute inflammation or as a primary affection. In the more diffuse forms the intestines are hopelessly matted together, and the omentum may be rolled up and contracted into a rounded cord-like mass, lying transversely across the upper part of the abdomen ; chronic obstruction is almost certain to arise sooner or later from this condition. Occasionally the existence of persisting localized pain may indicate the presence of a solitary adhesion, passing between the abdominal wall and one of the viscera, such ABDOMINAL SURGERY 899 as the anterior wall of the stomach. In such cases an explanatory laparotomy is permissible, the adhesion if found being divided between ligatures. The importance of dealing with such adhe- sions, where possible, is evident from the fact that internal strangulation beneath them, or acute kinking of the gut over them, is one of the commonest forms of acute obstruction. Tuberculous Peritonitis. — This disease is almost limited to young people, and is usually secondary to some other focus of intra-abdominal tuberculosis, e.g., in the intestine, mesenteric glands, Fallopian tube, etc. It is sometimes limited in its development to a portion of the peritoneal cavity, especially when it is of pelvic origin, but is more frequently diffuse. It manifests itself in several different ways: (1) In the ascitic variety the peritoneum becomes thick and hyperaemic, and studded over with tubercles, some of them small, grey and translucent, others larger and undergoing caseation. The effusion is generally abundant, and consists of straw-coloured or opalescent serum, perhaps blood-stained in the more active cases. Flakes of fibrin may be found covering the membrane here and there, but there is no extensive matting of the intestines. Occasionally the effusion becomes encapsuled, giving rise to cystic swellings shut in between the coils of intestine. (2) In the fibrous variety the intestines become matted together by extensive adhesions, and between them foci of tubercle are found. The mesentery may become infiltrated and shrink, fixing the intestines back en bloc to the posterior abdominal wall. The omentum is often invaded, and contracts upwards to form a sausage-like tumour lying transversely above the umbilicus. There is but little effusion, and that is usually encapsuled. It is obvious that such a condition is very likely to lead to obstructive phenomena, due to kinking of the intestine. (3) The ulcerous variety is characterized by an exaggeration of the above phenomena. Tuberculous foci are found between the coils of intestine, and open into them, giving rise to various inter- intestinal fistula? (Vistula bimucosa), or even opening externally. In each of these varieties acute manifestations may develop at any time as a result of infection from the bowel with the Bac. coli, and then the symptoms of acute diffuse peritonitis may supervene. The symptoms are very variable. Any and every form of diges- tive disturbance may occur, including diarrhoea, or alternating attacks of constipation and diarrhoea, with some amount of colic and vomiting. The onset is generally gradual, but intermissions and relapses are of frequent occurrence. Wasting is, however, always a marked feature. The abdomen is enlarged, perhaps tender to the touch, and may contain free fluid or not. Treatment in the early stages is often successfully undertaken by the physician ; but if the condition is progressing, the surgeon may be called upon to deal with it by laparotomy. When marked ascitic accumulation is present, all that is needed is to remove 57—2 900 A MANUAL OF SURGERY the fluid and close the wound with or without irrigation, and in nearly 75 per cent, of the cases a cure may be anticipated. Where diffuse or localized suppuration is present, adhesions which can be reached may be gently broken down, exit given to the pus, and the peritoneal cavity washed out ; but no prolonged search after suppurating foci should be made, or the intestine may be torn. The results of treatment in this variety are not nearly as satisfactory as in the former, at least 40 per cent, of the cases dying. As to the way in which cure is established, opinions differ, some authorities considering that it is due merely to the admission of atmospheric air, some to the alteration produced thereby in the intra-abdominal tension, whilst others maintain that it is simply in consequence of the removal of the exudation and its contained toxins. The most plausible idea, however, attributes it to a flushing of the intra-abdominal tissues with blood serum (a well-ascertained fact after laparotomy) and the effect of the antitoxic substances contained therein, the tubercles thereby having their vitality destroyed. In this connection one may note the statement that too early a laparotomy does but little good, an insufficient amount of antitoxin having presumably developed in the system. Paracentesis Abdominis is required in cases of general or encysted ascites. The usual plan adopted is to seat the patient on a chair, and to encircle the abdomen with a flannel binder, the ends of which are split to within 6 inches of the middle line. The unslit portion is placed over the abdominal wall in front, whilst the divided portions cross behind, and are held by assistants, so as to make continuous pressure upon the abdominal contents. The abdomen is carefully percussed, and a spot of absolute dul- ness selected ; here a small skin incision is made with a scalpel, and a suitable trocar and cannula inserted. The median line below the umbilicus is the place usually chosen for the puncture, but there is no objection to inserting the trocar through the flanks. Some surgeons prefer to withdraw the fluid more slowly, so as to prevent the shock often experienced from its rapid removal. Two or three Southey's trocars and cannula' may then be inserted. Subphrenic Abscess is the term applied somewhat loosely to a suppurating focus which is in more or less intimate relation with the under surface of the diaphragm. Two main varieties are described, viz., the intraperitoneal, which is much the more common, and the retro- or extra-peritoneal. The causes are very diverse, and the manifestations vary somewhat with the causative lesion. 1. The stomach is the most frequent source of the trouble, the infection being due to the extension of a chronic ulcer. If the anterior wall is involved, the pus will be limited by the lesser omentum and stomach behind, by the diaphragm and left lobe of ABDOMINAL SURGERY 901 the liver above, by the falciform ligament on the right, and by adhesions between the stomach or omentum and anterior abdominal wall below. This type of abscess usually points to the left of the ensiform appendix. Should the ulcer be situated on the anterior wall near to the fundus, the abscess may get into close relationship with the spleen, and point beneath the left costal margin. When the abscess arises in relation with the posterior wall, the lesser sac of the peritoneum may be filled with pus, which is prevented from escaping from the foramen of Winslow by adhe- sions, whilst the stomach itself is pushed forwards, and the pus travels up and presents above it to the left of the middle line. More often the lesser sac has been previously obliterated, and the abscess develops in the retroperitoneal tissues. 2. Ulcer of the duodenum may give rise to very similar conditions. If the abscess is intraperitoneal, it is bounded by the liver, colon, omentum, and anterior abdominal wall ; occasionally it has also tracked up behind the liver. Retroperitoneal suppuration also occurs in con- nection with the duodenum, the pus then travelling up between the liver and diaphragm, or downwards towards the loin. 3. The append/'. >• vermiformis is also a cause of subphrenic abscess, the pus burrowing behind the peritoneum, or finding its way along the inner or outer walls of the ascending colon. 4. It may also be caused by extension of suppuration from the liver, colon, intestine, or from retroperitoneal structures, such as the kidney, ribs, or vertebrae. According to Fenwick, however, 80 per cent, of all cases of subphrenic abscess are due to ulceration of the stomach or duodenum. The abscess thus induced may contain pus alone or, in addition, gas, which is derived either from a direct communication with the bowel, or from the activity of the Bacillus colt without any direct opening being present. It w r as to this condition that Leyden originally gave the name of subphrenic pyo-pnciimothorax. The extension of the abscess along the under surface of the diaphragm often leads to that structure being displaced considerably upwards, and to a secondary infection of the pleura, either by lymphatic absorption and extension, or by an actual solution of continuity. The effect is an effusion of serum or pus into the base of the pleural cavity, the latter constituting a basal empyema. The symptoms vary considerably. They may commence ab- ruptly, as from a perforated stomach, or come on more gradually. Ordinary febrile phenomena, and perhaps one or more rigors, may occur, whilst the patient complains of pain in the upper portion of the abdomen, where a swelling, dull or tympanitic according to circumstances, appears, over which the abdominal muscles are rigidly contracted. The condition is very liable to be mistaken for an empyema or pneumothorax, but one most important dis- tinguishing feature is that the heart is displaced directly upwards and not to one side, as in the pulmonary conditions, whilst the 902 A MANUAL OF SURGERY liver is pushed downwards. Left to itself the abscess may burst into the general peritoneal cavity, or into one of the hollow viscera, or may open externally. The treatment of subphrenic pyo-pneumothorax consists in opening the abscess wherever it is most accessible. Opinions differ as to whether it is necessary to make a counter-opening behind ; in all probability, it is wiser not to attempt this at first, but if the temperature still keeps up, and the cavity does not seem to drain well after a few days, then further interference will be reqviired. The best situation for a counter-opening is behind the mid-axillary line, a portion of the eighth or ninth rib being excised. If, as often happens, there is also an empyema, this is readily accomplished, and an additional opening can be made through the diaphragm if one does not already exist ; if, however, the pleural cavity is not affected, then the serous mem- brane covering the upper surface of the diaphragm must be stitched to the parietal pleura before the diaphragm is incised. Affections of the Stomach. Rupture of the Stomach results from blows or falls upon the epigastrium, especially after a heavy meal, and then usually in- volves the pyloric end or the greater curvature near the cardiac orifice. It may also follow a penetrating injury, such as a stab or a fall upon a spike or railings. Neighbouring viscera are not unfrequently involved in the lesion, especially the liver or spleen. The Symptoms are those of severe and prolonged shock, with epigastric pain and vomiting, the ejected material often containing blood ; acute septic peritonitis usually ensues in a very short time, destroying the patient's life in a few days. Occasionally, when the wound is small, or the organ empty at the time of the accident, there is but little or no extravasation, and then a localized intra- peritoneal abscess may form, shut off from the general peritoneal cavity by adhesions, and sooner or later bursting and discharging into the stomach, colon, or one of the hollow viscera, or else tracking along the parietal wound so as to reach the surface, or even sometimes breaking down the barrier of adhesions, and originating a late general peritonitis. If the posterior wall of the stomach is alone injured, the resulting phenomena are very similar to those due to the perforation of an ulcer (q.v.). Treatment. — When a wound perforating the abdominal parietes is present in the region of the stomach, it is always the surgeon's duty to enlarge the opening, and ascertain what amount of internal damage has been done ; but if there is no external wound, or merely a superficial one, a certain diagnosis cannot be made unless blood-stained vomiting is present. In doubtful cases the persistence of shock for some considerable time and the onset of peritonitis indicate that an exploratory laparotomy should be ABDOMINAL SURGERY 9°3 undertaken. No time must, however, be lost in cases where the diagnosis is tolerably certain, since the only hope of saving the patient's life lies in early interference. A median incision is made above the umbilicus, the situation of the injury in the stomach ascertained, and the aperture clamped by forceps so as to prevent any further exit of the gastric contents whilst the peritoneum is being cleansed. All extravasated material should be carefully sponged or swabbed away, and if the general cavity has not yet become inflamed, irrigation should be avoided for fear of carrying infective material to other regions. The wound in the stomach is closed by a row of Lembert's sutures, which tuck the margins inwards, and these must extend a little beyond the lesion on either side (Figs. 328 and 329). If the posterior wall is also injured, as by a bullet wound, an opening should be made through the omen- tum so as to explore and cleanse the lesser sac of the peritoneum. If the case has been operated on early and there is but little peritoneal inflammation, it may be possible to close the parietal wound entirely ; but, as a rule, it is necessary to drain the upper part of the serous cavity by inserting a plug of gauze down to and around the site of the injury. If the general cavity is inflamed, the treatment suitable to acute peritonitis must be instituted (p. 897). It will probably be wise under these circumstances to place a drainage-tube immediately above the symphysis pubis, as well as leaving the upper incision partly open. Foreign Bodies in the stomach consist either of those which have been swallowed accidentally or intentionally, or of con- cretions, e.g., hairs, wool, etc., due to the constant ingestion of small portions which remain in the viscus, and may after a time form large masses. The presence of the former is known from the history, whilst the latter may give rise to symptoms of gastric irritation, the cause of which is inexplicable until the mass has attained such a size as to suggest the presence of a tumour. The only treatment possible where the foreign body is of any size is to open the organ and remove it (gastrotomy) ; where, however, it is of small dimensions e.g., a coin, it may be allowed to pass onwards. Ulcer of the Stomach is an exceedingly common ailment, the consequences of which are often very serious, a considerable mortality being associated with it, its complications, or its sequelae. Two chief types may be mentioned here, although others are not unknown : (a) The acute ulcer is rarely larger than a sixpenny-piece, and ' develops with almost equal frequency at any spot between the cardia and the pylorus along the upper margin of the stomach, and more frequently on the posterior than on the anterior surface ' (Fenwick). It is not unusually multiple, two ulcers being often found exactly opposite one another, suggesting an 9 04 A MANUAL OF SURGERY infective origin of the trouble. They are of a circular shape, and with the edges sharply defined and clearly cut ; each succes- sive coat is destroyed to a lesser degree than the one internal to it, so that the sore is truncated or funnel-shaped. Should per- foration occur, the opening is not central, but slightly to one side. These acute ulcers heal without much difficulty, as is evident from the number of radiating cicatrices seen on the post-mortem table. They give rise to no stenosis, except perhaps when they are situated within the pyloric orifice. Haemorrhage from this variety is not uncommon, but is rarely fatal.* (b) The chronic ulcer may attain considerable dimensions, perhaps many square inches of each surface being involved. It is usually single, and situated on the posterior wall near the pyloric orifice, which may be involved in the trouble by extension. Its shape is very variable, though in the earlier stages it is rounded ; one important type is the horseshoe ulcer, which spreads down along either surface from the lesser curvature, and may subsequently cause an hour-glass contraction of the organ. The edges are often raised, hard, and infiltrated, whilst the gastric wall is generally thick and sclerosed. In old-standing cases there may be considerable destruction of tissue, external viscera, such as the pancreas, being sometimes exposed in the wound. Haemorrhage is not uncommon, and may prove fatal ; one of the larger branches of the coronary artery, or perhaps the splenic, is then involved, or the bleeding may arise from one of the enlarged varicose gastric veins which are often found in the neighbourhood of an old ulcer. Perigastric inflammation of an adhesive or suppurative type is almost certain to occur, and cicatricial contraction of various forms is likely to follow. Women are much more liable to gastric ulcer than men, in the proportion of three to one ; but it is the acute variety to which they are most prone, and from which, apart from perforation, they seldom die. The usual age of such patients is from fifteen to thirty years. Men, on the other hand, are more liable to chronic ulcers, and though acute perforation is less common, they are subject to a number of serious complications which may prove fatal. Their average age when attacked is from thirty to fifty years. Into the aetiology, general symptoms, and routine treatment of gastric ulcers it is unnecessary to enter ; they are sufficiently described in medical text-books. A number of complications, however, arise which may require surgical assistance, whilst it must be remembered that the mere persistence of symptoms may justify operative measures, especially since the observation has * See Fenwick, ' Ulcer of the Stomach and Duodenum,' J and A. Churchill, 1900 ; and Mayo Robson and Moynihan, ' Diseases of the Stomach and their Surgical Treatment,' Bailliere, Tindall and Cox, 1901. ABDOMINAL SURGERY 905 been made and confirmed that malignant disease may commence on the site of an old-standing ulcer. 1. Excessive and Persistent Hemorrhage is responsible for quite a considerable proportion of the deaths from gastric ulcer. It may arise from arteries, veins, or capillaries, and at first it is difficult to say from what source it is derived. Inasmuch, however, as in over go per cent, of the cases it can be stopped by medical means, it is obvious that the capillary origin is most common. It is like- wise unusual for the patient to succumb as the result of the first attack of bleeding, and hence the rule of practice which is usually adopted, viz., to treat the first acute haemorrhage by medical means ; but should it recur or persist unduly, surgical assistance may be required. Under the latter circumstances the abdomen is opened and the stomach carefully explored. Some puckering or thickening of the coats may indicate the situation of the ulcer; failing this, a free opening is made through the anterior wall, and the interior of the viscus methodically examined. When the bleeding-point has been found, it may be possible to pick it up and tie it ; or the whole ulcer may be picked up and ligatured en masse ; or the base of the ulcer may be cauterized ; or excision of the ulcer may be practicable. Failing these measures, gastroenterostomy will be indicated, in order to give the organ as much rest as possible. 2. Perforation of the Ulcer is by no means an uncommon occur- rence in connection with the acute type of ulcer, and is therefore seen most frequently in young women ; it is always fraught with the greatest danger. The anterior wall is that most frequently involved, owing to its greater mobility, which prevents the forma- tion of protective adhesions. The cardiac end is more often affected than the pyloric. The character of the symptoms varies with the size of the perforation, and with the distension or not of the viscus. If a large opening is produced in the anterior wall, so that the gastric contents are allowed a free entrance into the peritoneal cavity, the patient is seized with severe epigastric pain and profound shock, and this is followed by acute septic peri- tonitis, which rapidly proves fatal if surgical interference is not at hand. When the perforation is small, and only a gradual leakage occurs, the onset is subacute ; the primary shock is then inconsiderable, but epigastric pain and tenderness are present, and steadily increase until the characteristic features of general peritonitis supervene. The Prognosis of gastric perforation is exceedingly grave, since, unless active surgical interference is obtainable within a compara- tively short time, hopeless peritonitis ensues. Barling states that 95 per cent, of patients that are untreated are sure to die, whilst the later the operation, the worse the results. Treatment. — Should it be decided for any particular reason not 9o6 A MANUAL OF SURGERY to operate in a given case, the horizontal position, rectal feeding, and the use of morphia to check peristalsis, are the only means which hold out any prospect of benefit. Operation, as already indicated, must be undertaken at as early a period as possible, although it is often wise to delay for an hour or two to allow the patient to recover in measure from the initial shock. The median incision is the best to employ, since it is not possible to be certain as to the situation of the lesion. The rules given above as to the treatment of a penetrating injury hold good in connection with this subject, especially as to the use of swabs for the removal of any extravasated gastric contents, and as to the value of peritoneal irrigation. There is no need to excise the ulcer when found ; all that is required is to close the aperture by means of Lembert's sutures, applied perhaps in a purse-string fashion, so as to bury the ulcerated surface. In some cases it may seem unwise to attempt closure of the lesion, whilst in others it may be so situated as to render such closure impossible ; a drainage-tube, free from lateral openings, is then introduced into the stomach, and gauze packed around it so as to lessen the risk of intra- peritoneal leakage. The patient is fed by the rectum for some time, and the fistula usually closes without much difficulty at a subsequent date. 3. Perigastric inflammation is a common result of ulceration ; it may be either adhesive or suppurative in character. Adhesive perigastritis is in the first place protective in nature, consisting of a localized thickening of the serous wall. It is more marked in connection with chronic than with acute ulcers. The posterior gastric wall is often adherent across the lesser sac of the peritoneum to the serous membrane lying in front of the pancreas, and this fixity may be one of the factors which prevent the ulcer from healing, even as fixation to the periosteum over the tibia delays healing in an ulcer of the leg. In a few cases adhesions form between the anterior wall of the stomach and the parietal peritoneum. Such give rise to a localized fixed epigastric pain, usually increased considerably by distension of the organ. It may be treated safely by abdominal section, and division of the adhesion between ligatures. If left alone, not only may it cause inconvenience by the pain induced, but it may also determine internal strangulation or obstruction. Suppurative Perigastritis may follow a small perforation with limited leakage, but is more usually due to an extension of the ulcer and an invasion of the perigastric tissues by organisms which escape from the stomach. The result of this is the formation of what has been already described as a subphrenic abscess (p. 900), which may or may not contain gas. It may burst anteriorly through the abdominal wall, or may perforate the diaphragm, giving rise to a basal empyema ; and this in turn may burst into the lung or through the chest wall, so that fistulae may appear in ABDOMINAL SURGERY 907 various places, through which the contents of the stomach may be discharged. The abscess should be opened and drained in the way already indicated, but should a fistula form, it is almost hopeless to attempt to deal with it locally, so that it would be wise to perform a gastro-enterostomy. 4. Stenosis is always liable to occur after ulcers of the stomach, as in other situations. If it is located near the pylorus, that orifice may become contracted, giving rise to special symptoms, and necessitating treatment of a particular character (p. 911). Occasionally, however, the cicatrisation of a horseshoe ulcer leads to an hour-glass contraction of the body of the viscus, which in some cases is so marked as almost to divide the organ into two halves, only a narrow neck persisting between the two. The symptoms of such a condition are almost identical with those of pyloric stenosis, and the treatment required consists either in excision of the sulcus and reunion of the gastric walls, or in establishing an artificial opening between the two segments, as by a Murphy button. In still other cases the contraction may be situated near the cardiac orifice, the symptoms then being similar to those of a stricture at the lower end of the oesophagus. The clinical phenomena of an hour-glass stomach vary with the situation of the contraction, resembling sometimes those of pyloric stenosis, at others those of contraction at the cardiac orifice. The diagnosis is best made by inflating the organ with air, when its shape can be easily detected. Treatment of stenosis at the cardiac end consists in gastrostomy. An hour-glass stomach may possibly be treated by excision of the stricture, or by its division and suture by a method similar to that employed for the pylorus (see Pyloroplasty, p. 916), or the two segments may be united below the contraction by a Murphy button, or a double gastro-enterostomy may be performed to connect each segment to the jejunum. 5. Finally, cases are met with in which the symptoms of gastric ulcer persist or recur in spite of the most careful dieting and treatment, and it is now considered quite justifiable to submit such cases to operation. Two lines of treatment are possible, (a) The ulcer may be excised, if it be in a convenient position for such a procedure, and if the infiltration around it be not too extensive. (b) In other cases gastro-enterostomy (p. 918) maybe undertaken with a view to relieve symptoms by enabling the viscus more readily to empty itself after the ingestion of food. The results of this latter procedure have been very satisfactory. Cancer of the Stomach. — The stomach is more frequently invaded by cancer than any other organ in the body in the male sex, whilst in females it comes next to the breast and uterus in order of frequency. Any and every part of the viscus may be 9o8 A MANUAL OF SURGJ-hV affected, but in 60 per cent, of the cases the tumour starts in or about the pylorus, and is of a scirrhous nature. When the cardiac end is attacked, the disease may spread from the (rsophagus and is a squamous epithelioma, but when the body of the organ is invaded, the condition is usually a columnar carcinoma. Cancer occasionally starts at the site of an old ulcer, but there is generally no assignable cause for its onset, except an indefinite history of injury. It may occur as a nodular outgrowth, perhaps covered with papillomatous projections and early under- going ulceration ; if it is of a hard type, the ulcerated surface has a characteristic everted margin. Sometimes the whole organ becomes infiltrated by a diffuse carcinomatous growth, con- stituting a firm mass incapable of dilatation or much contraction, which has been aptly termed the 'leather-bottle stomach.' At Fig. 318. — Cancer of Pyloric End of Stomach. (King's College Museum.) The abrupt limitation of the growth at the commencement of the duodenum is well seen. the pyloric end (Fig. 318) the growth is always of a hard nature, and forms an annular constriction, through which it may be difficult to pass even a small catheter ; it is sharply limited on its duodenal aspect, but spreads into the body of the organ, and especially towards the lesser curvature, following the main line of the lymphatic stream. The lymphatic glands lying along the lesser curvature are involved, usually extending as far as the point where the coronary artery reaches the stomach, whilst those along the pyloric end of the great curvature are implicated to a less degree. Thence the affection spreads to the liver and to the coeliac glands, and there may compress the inferior vena cava and thoracic duct. Adhesions form around the growth, tending to fix it to the under surface of the liver, to the head of the pancreas, the colon, and even when of large size to the anterior abdominal ABDOMINAL SURGERY 909 wall. These adhesions often prepare the way for an extension of the disease to the peritoneum, over which disseminated nodules of cancer may be scattered, often giving rise to a considerable effusion of serous fluid. The omentum also becomes infiltrated, and colloid degeneration is not unusual in this region, the omentum being converted into a solid translucent mass, looking sometimes like firm sago pudding. Speaking generally, the malignancy of gastric carcinoma is decidedly less than that of such organs as the breast or uterus, in that secondary glandular affections are later in developing, and even when the nearest group is involved it may be some time before the affection spreads to distant parts. Clinical Phenomena. — Gastric cancer often begins with certain indefinite symptoms, the significance of which is easily overlooked in the early stages ; the case is then often allowed to run on with the idea that it is merely one of ' dyspepsia,' ' internal influenza ' or the like, so that a thorough and exhaustive examina- tion is not made, and the time for radical interference passes without the disease being recognised. Pain is often the first symptom, slight at first, but gradually increasing, and referred to the epigastrium or back. Food may increase or relieve it, but as time progresses the pain comes on independently of meals. Acid eructations and a sense of epigastric oppression soon follow, and these in time give place to actual attacks of vomiting, the ejecta perhaps containing blood, but usually not till late in the case. Loss of appetite and steady wasting are also marked features in the early stages. The persistence of such a group of symptoms should always lead to a complete investigation of the stomach and its functions, (i.) The epigastric region is carefully palpated and the nature and position of any unusual swelling noted. It may be desirable to inflate the organ with air or gas and ascertain its exact size ; by this means it is sometimes possible to detect a tumour which would otherwise escape notice, (ii.) The composi- tion of the gastric juice may be investigated by the use of a test meal and the stomach tube. In cancer the amount of HC1 is usually diminished, whilst that of lactic acid is increased. The latter is probably a fermentation product, (iii.) The motor power of the viscus is very considerably lessened, so that the passage of its contents into the duodenum is delayed ; this can be demon- strated by the salol test, (iv.) A blood count in carcinoma usually reveals a well marked diminution in the amount of haemoglobin, sometimes fewer red corpuscles, and a moderate leucocytosis, especially involving the mononuclear leucocytes, (v.) Microscopic examination of the vomit may also throw light on the case. To these general signs certain special ones may be added, varying with the location of the growth. 1. If the cardiac end is involved, a tumour can rarely be detected, the stomach being small and contracted. The patient complains chiefly of pain on 9 io A MANUAL OF SURGERY swallowing, and the vomiting occurs immediately alter each meal. The symptoms are practically those of oesophageal cancer. 2. When the pylorus is affected a tumour can often be felt a little above and to the right of the umbilicus, which is at first rounded and definitely limited, except on the left side, where it shelves off into the stomach ; it is moveable in the early stages, but later on becomes fixed ; it is firm in consistence, and some- what tender on manipulation and pressure, and may receive pulsation from the underlying aorta. Owing to the stenosis of the pylorus, which almost invariably accompanies this condition, the stomach becomes dilated, and its great curvature displaced downwards, perhaps almost into the pelvis. In this a large accumulation of fluid takes place, which can be heard splashing about when the patient is moved ; every two or three days he brings up a large quantity of fluid and decomposing food, covered with a yeast-like scum, and containing sarcinae in abundance. Haematemesis is not uncommon. 3. When the body of the organ is involved, a tumour may or may not be felt, according to its situation. The ' leather-bottle ' stomach can be sometimes detected as a solid mass projecting forwards from under the left costal margin. The organ is not dilated, and the vomiting has no special characters ; haematemesis may or may not be present. In the later stages pressure phenomena manifest themselves. Ascites may result from compression of the portal vein ; jaundice, from implication of the common bile duct ; oedema of the legs and varix of the superficial abdominal veins may arise from pres- sure upon the inferior vena cava, whilst the peritoneal cavity may be distended with chyle owing to the pressure of lymphatic glands on the receptaculum chyli or thoracic duct. All these later signs are indications that the time has passed when radical treatment is possible. Treatment. — So many cases of this affection reach the surgeon too late that, at the risk of wearying our readers, we would reiterate what has been already stated. When the symptoms of chronic gastritis persist in spite of careful dieting and treatment, and the patient is losing flesh, one should always look on the case with suspicion. Granted that the examination of the gastric juice reveals the characteristic changes referred to above, and still more when a blood count indicates leucocytosis and a diminishing quantity of haemoglobin, then an exploratory operation is quite justifiable. On the other hand, we would give a word of warning against the common practice of considering that the mere presence of a tumour in the epigastrium warrants an operation. When a well-marked tumour is present, the probability is that the disease has extended beyond the reach of surgery, and therefore, unless there are distinct indications for palliative treatment, e.g., the signs of pyloric stenosis, the patient is often better left to the care ABDOMINAL SURGERY 911 of the physician. Of course, in many cases an operation is under- taken in the almost vain hope of being able to do something to prevent the patient being condemned to certain death ; but when ascites, jaundice, or definite evidences of dissemination are present, the surgeon should be very chary of interfering. For cancer of the cardiac orifice, gastrostomy may possibly be desirable, the artificial stoma being placed nearer to the pylorus than usual. For cancer of the body of the stomach, a partial or total gastrectomy may be feasible in the absence of massive adhesions ; but the conditions which permit of such procedures are unusual. If the patient's nutrition is seriously failing, and no radical operation is possible, jejunostomy (or the formation of an artificial opening into the jejunum) may enable the patient to be fed without utilizing the stomach. For cancer of the pylorus, operation is more frequently possible, whilst, even if removal is impracticable, palliative measures to short-circuit the grow r th may be desirable. If the mass is compara- tively moveable, and there are but few adhesions, pylorectomy or removal of the diseased portion of the organ may be undertaken, and even should secondary deposits be present in the liver, the patient is probably better off after such a procedure than if left alone. When the growth has extended beyond the bowel to adjacent viscera, and extensive adhesions are present, gastro- enterostomy is alone practicable, and will do much good by per- mitting of the passage of food into the bowel without passing through the pylorus. It will also allow the dilated organ to be more completely emptied, and consequently the patient will not be so likely to absorb toxic material. Simple Stenosis of the Pylorus generally results from the healing of a simple gastric ulcer of the usual type, situated within or close to the pyloric orifice ; it is sometimes due to the contraction of adhesions around an inflamed gall-bladder (cholecystitis), and is occasionally caused by hypertrophy of the muscular tissue of the sphincter. The effects produced are hypertrophy and dilatation of the stomach, which becomes enlarged downwards, and forms a sac, in which food collects perhaps for days, and undergoes fermenta- tive changes, being finally ejected in large quantities, mixed with frothy mucus and a yeast-like scum containing an abundance of sarcina;. The stomach may in time almost reach the pelvis, the pylorus being dragged down with it. Succussion or splashing sounds are heard on shaking the patient's abdomen. The Treatment consists at first in washing out the stomach regularly, but when that fails to give relief one of the following proceedings may be undertaken, (a) Loretas Operation consists in dilating the stenosed orifice with the finger. The viscus is opened midway between the curvatures and about 2 inches from 912 A MANUAL OF SURGERY the pylorus, and first one finger is introduced, slowly and care- fully, then two, and even perhaps three ; no violence is admissible, or the walls of the orifice may be torn or ruptured. The results of this procedure have been on the whole encouraging, but it is now being replaced by other more certain and satisfactory methods, (b) Excision of the Pylorus can be undertaken in suitable cases, and the results have been so much improved by the use of the Murphy button and other similar contrivances that it need not be greatly feared. Of course, when the stomach is much dilated and very atonic, it is possible that this operation may not succeed in improving the function of the organ, (c) Pyloroplasty is useful in cases where the stricture is free from adhesions, and where it is narrow and annular, but will be useless in conditions similar to those under which pylorectomy is contra-indicated. (d) Under such circumstances Gastro-cntevostomy should be under- taken, and may be expected to give admirable results. Operations upon the Stomach. i. Washing oub the Stomach is needed in cases of poisoning, in chronic catarrh, in dilatation of the organ, and as a preliminary to operations in which its cavity is to be laid open. It may be accom- plished by the ordinary stomach-pump, or by the simpler method of passing a long tube of good-sized calibre, to the upper end of which is attached a funnel. Fluid is introduced through the funnel, and syphoned out by lowering it below the level of the stomach. Before open operations, a warm solution of boric acid should be employed as the agent for irrigating the viscus. 2. Gastrotomy, or opening the stomach, is required for the removal of foreign bodies from it or from the lower end of the oesophagus, for exploratory purposes, and as a means of dilating simple strictures of either the pyloric or cardiac orifices (Loreta's operation). It has also been employed with advantage for the removal of masses of cancerous disease by curetting. Operation. — When a foreign body can be distinctly felt within the viscus, any incision that seems to promise ready access may be employed ; but it is generally made on the left side, parallel to, and about a finger's breadth from, the edge of the costal cartilages, and about i\ inches in length (Fig. 319, A). The position of the left lobe of the liver must be previously ascertained by percussion, and the centre of the incision is best placed about \ inch below it. The abdominal wall is completely divided, and the peritoneum opened. The fingers are then introduced, and the stomach sought for ; it is recognised by its position im- mediately under the liver, and by the thickness, pink colour, and opacity of its wall. If the omentum or transverse colon presents in the wound, it must be pushed down, and the stomach looked for above. The spot where the stomach is to be opened is now ABDOMINAL SURGERY 9IJ decided on, and two silkworm gut sutures introduced through the serous and muscular coats, so as to enable the organ to be kept against the abdominal wall, a careful packing with a known number of sponges or gauze swabs being also interposed between the viscus and the parietes, so as to prevent any escape of fluid into the general peritoneal cavity. An incision is made in the long axis of the stomach, and the finger inserted. The removal of a foreign body must be undertaken with great care, so as not to inflict injury on the organ, the wound being enlarged, if necessary. It is subsequently closed by the Lembert or prefer- ably the Czerny-Lembert suture. The stomach is now replaced Fig. 319. — Incisions utilized in Various Abdominal Operations. A, Fenger's incision for exposing the stomach ; A,, additional incision in Frank's gastrostomy; B, incision for exposing gall-bladder; C, iliac colotomy ; D, incision for operations on appendix; E, median incision for ovariotomy or supra-pubic cystotomy ; F, for radical cure of inguinal hernia or varicocele. in position, and all traces of blood, etc., removed, the external wound being closed in the usual way. If the surgeon desires to reach the cardiac orifice, a somewhat larger opening in the parietes is needed, in order to allow of greater space for the introduction of the hand into the abdomen, since the orifice lies deeply just in front of the aortic opening in the diaphragm. When this is accomplished, the opening may be dilated by the fingers or by suitable dilators, and a foreign body can by this means be removed from the lower end of the oesophagus. The utmost gentleness must be observed in this proceeding, as serious symptoms may be caused by irritation and damage of the pneumogastric nerves, the terminations of which pass through this opening in the diaphragm. 58 9'4 A MANUAL OF SURGERY The operations on the pyloric orifice are dealt with below. 3. Gastrostomy consists in the formation of a permanent artificial opening into the stomach, through which the patient can be fed. It is needed in cases of malignant disease or intractable stenosis of the cesophagus, where the patient is exposed to the risk of starvation, owing to his inability to take nourishment. Not many years back the only operation performed was one in which a direct opening was made into the viscus without any *N\/j J V- V ,/ /'i m^i/ # V*""' ;//', f / yJ Figs. 320, 321. — Gastrostomy (Modified Frank's Operation). In Fig. 320 the base of the cone is seen sutured to the peritoneum and sheath of the rectus; in Fig. 321, the stomach has been opened, a tube stitched in, and the sutures passed through the rectus are in place. attempt to form a valve, trusting to various flanged tubes or umbrella-like plugs to close the aperture. The results were most unsatisfactory, since even if the patient survived, he usually suffered great inconvenience from the prolapse of the mucous mem- brane, and from irritation and ulceration of the surrounding skin, owing to escape of the acid gastric juice and its digestive powers. During the last few years a number of excellent operations have been introduced so as to prevent these complications, most of them depending on the formation of a muscular valve or sphincter, and there can be no doubt that the improvements thus effected have been very great. Two chief methods have been suggested — viz., Witzel's and Frank's ; the latter of these is, to our minds, the preferable, and the results gained thereby are so satisfactory as to warrant us in describing it in detail. ABDOMINAL SURGERY 9*5 Frank's Operation. — The usual oblique incision (Fig. 319, A) for exposure of the stomach is first made, the viscus withdrawn and examined, and a silk sling passed through the serous and muscular coats at the site selected for the artificial opening, so that a cone- shaped portion of the wall can be drawn up into the wound. The parietal peritoneum is then sutured all round to the base of the cone, so as to shut it off from the general serous cavity. A second incision (Aj), about 1 inch in length, is now made on the *f3& Figs. 322, 323. — Gastrostomy (Frank's Operation Modified). In Fig. 322 the sutures in the rectus have been tied, and only a small portion of the stomach projects ; in Fig. 323 the operation is completed. outer side of the first wound, parallel to it, and about 1^ inches from it. The bridge of skin and subcutaneous tissue between the two is separated from the subjacent structures, and the apex of the cone of gastric wall drawn under the bridge into the second wound. A small opening is then made into the viscus through the apex, in which the silk sling is located, and the mucous membrane stitched accurately to the skin in the centre of the incision. The remainder of this incision is then closed in the ordinary way, as also the first. Healing readily occurs, and thus a valvular opening is established, which passes in an angular fashion round the margin of the costal cartilages, tending to prevent regurgita- tion of the gastric contents. The patient may be fed by the artificial opening at once. We have somewhat modified this operation of late, and the results have been still better than when we utilized Frank's 58-2 9 ,6 A MANUAL OF SURGERY original method. Instead of the oblique incision, a vertical one (as suggested by Kocher) is employed, extending for 3 or 4 inches downwards from the eighth costal cartilage and passing through the substance of the rectus muscle (Fig. 320), which is split by the ringers or handle of the knife into two portions. The peritoneum is opened, and the stomach withdrawn ; a cone-shaped portion is selected, and its base stitched to the parietal peritoneum and pos- terior layer of the sheath of the rectus. A small hole is made in the apex of the cone, and through this is passed a piece of rubber drainage-tube, free from lateral openings, and about the size of a No. 10 catheter, fitting the opening in the stomach exactly ; it should project 1 J inches inside the cavity, and about 6 inches of it should remain outside (Fig. 321). This is stitched firmly to the stomach wall, and the apex of the cone is then drawn to the upper angle of the incision. The halves of the rectus muscle are freed from the posterior layer of the sheath and drawn together by sutures, so as to cover in all the exposed gastric wall except the apex of the cone, which with the tube forms a nipple-like projection, around which the muscle fits like a sphincter (Fig. 322). The in- cision in the skin is then closed, and finally the serous and muscular coats of the projecting portion are carefully stitched to the skin. The results of this procedure have been most satisfactory, many cases having run their course without a drop of gastric juice escap- ing. The amount of food at first administered is small, and rectal feeding may be required in addition ; but it is gradually increased until perhaps 17 oz. can be retained four times a day. The patient should be kept in the recumbent posture for three weeks.* WitzeVs Operation. — This consists in making a valvular opening into the stomach by introducing and stitching a tube into it as in the last proceeding, and then burying the projecting portion as far as possible by suturing the serous and muscular coats together over it. The stomach is then fixed to the abdominal parietes and the skin closed. The functional result of this operation is very good, but the fixation to the abdominal wall is not so secure as in the former plans. 4. Gastrectomy. — A good many cases have now been reported in which a limited portion of the gastric wall has been removed successfully, either for simple or malignant ulcers or growths. Incisions are made so as to include the mass, and the wound is subsequently closed by Lembert or Czerny-Lembert sutures. Total excision of the stomach is a proceeding which has only recently been attempted, but several successful cases are now on record. It has been undertaken for extensive malignant disease, which, however, has left enough of the oesophageal end free to allow of its apposition and fixation either to the upper end of the duodenum, or, if that cannot be brought across to it, to a suitable * For further details, see Carlcss, ' On Gastrostomy,' King's College Hospital Reports, vol. v., 1897-1898, and in Edinburgh Medical Journal, July, 1902. A BDOMINA L SUliGER Y 917 coil of the jejunum. The actual union has been effected either by simple suturing, or by introducing a Murphy button. 5. Pyloroplasty consists in exposing the pylorus and clearing it from adhesions. A longitudinal incision is then made through the stricture, and by a little careful manipulation this wound can be opened out and brought together in a transverse manner so as Fig. 324. — Pyloroplasty. The contracted bowel is divided longitudinally, and the aperture thus made opened out, so that it can be brought together transversely. to greatly increase the lumen of the orifice (Fig. 323). Two rows of stitches are inserted, one through the mucous membrane, and the other through the muscular and serous coats. 6. Pylorectomy is an operation which has been performed both for simple and malignant stricture of the pylorus, but until quite recently the mortality connected therewith was so great as to ~^^€^.i~^^^^^ Fig. 325B. — Method of suturing Fig. 325A— Malignant Growth of the Unequal Wounds left the Pylorus, and Incisions in a " er Removal of the Growth Stomach and Duodenum needed (Iillmanns.) for its Removal. (Tillmanns.) The upper end of the gastric incision is first closed, so as to render the openings in the stomach and duo- denum of equal size. render it almost a hopeless procedure. Thus, in seventy-two cases deal twith for malignant disease by the old plan of operating, fifty-five died from the immediate effects, whilst in ten cases of simple stricture only four recovered. The latest statistics of operations in which the Murphy button was employed are, how- ever, much more encouraging. (a) In Billroth' s operation the abdomen is opened by an incision which suits the exigencies of the case, though perhaps the best to employ is a median one or an 9i8 A MANUAL OF SURGERY oblique one 4 or 5 inches long, extending from the median line above downwards towards the right, nearly parallel to the right costal margin (Fig. 319, B). The diseased area is now explored, and a final decision made as to the practicability or not of reriioving it. If an operation is determined on, the growth is carefully isolated from surrounding parts by dividing the attachments of the great and lesser omenta, any enlarged glands being also enucleated. Clamps are then applied to the stomach and duode- num, and the operation area well packed round with sponges. The mass is now removed (Fig. 325A), the incision being so placed as to extend beyond the pylorus about f inch into the duodenum on the one side, and on the other so as to remove the greater portion of the lesser curvature, thereby including the lymphatic glands. The divided ends are apposed and united (Fig. 32513), but for exact details we must refer to larger text-books of operative surgery. The operation is prolonged and difficult, and profound shock is usually experienced. Carefully regulated stomach- feeding should not be too long delayed after the operation, the best results having occurred in those cases where it was started early, (b) When the Murphy button is employed, the same steps are followed until the growth is isolated, and then the mass is cut away at once. The gastric wound is then entirely closed by a row of Czerny-Lembert sutures. The heavier male end of a Murphy button is inserted into the open mouth of the duodenum, and the purse- string suture tied, as de- tailed below (p. 936), whilst the female half is placed in a new opening made for it in the posterior wall of the stomach, as for a lateral anastomosis (p. 938). The two halves are united, and the operation is then completed by the usual toilette of the peri- toneum and the closure of the parietal incision. 7. Gastro - enterostomy may be undertaken by simple suturing of the required viscera together (Worrier's operation), or by the use of the Murphy button. The portion of bowel which is selected as the site of the artificial opening should be the upper part of the jejunum, since if the communication is established too low, a much greater ab- sorbing surface is isolated, with the result that even if the operation is successful the patient gradually emaciates owing to Fig 326. Anterior Gastro -enteros- tomy. A, Transverse colon ; B, jejunum dragged up over the colon and omentum (pur- posely omitted) to be brought into apposi- tion with the stomach ABDOMINAL SURGERY 919 lack of nutriment ; and the rapidity of the emaciation will increase as the communication is placed further from the duodenum. The incision employed is usually one in the middle line through the linea alba. The stomach is readily found, and the condition of the growth examined so as to determine whether or not it is removeable. Formerly it was the practice to unite the bowel to the anterior wall of the stomach (Fig. 326), but there are two obvious objections to this method : (a) The jejunum is drawn up over the transverse colon, and is likely to constrict it and lead to obstruction ; and (b) the necessary drag of the gut is apt to bring the two ends parallel to each other, and thus produce a spur or kink, by means of which the bile is directed into the stomach instead of into the efferent limb. Severe bilious vomiting results, which may prove fatal. Hence the majority of surgeons nowadays follow with advantage the plan recommended by Von Hacker of utilizing the posterior gastric wall for this purpose. It is accomplished in the following manner : The transverse colon is withdrawn from the wound, together with part of the omentum. By tracing down the transverse meso-colon to its attachment to the pos- terior abdominal parietes, the termination of the duodenum is reached as it crosses the middle line along the lower border of the pancreas, and with the superior mesenteric vessels lying in front of it ; by this means the upper portion of the jejunum is easily found, and a suitable spot for making the anasto- mosis selected. A hole is then made through the trans- verse meso-colon (Fig. 327), so as to open into the lesser sac of the peritoneum, and enable the posterior wall of the stomach to be reached. A clamp is placed on either side of the selected portion Fig. 327. — Posterior Gastroenteros- tomy. (Von Hacker's Operation.) A, Transverse colon turned up together with the omentum (which is omitted from the drawing) ; B, coil of small intestine, which is brought into con- tact with the posterior wall of the stomach through C, a hole in the trans- verse meso-colon, the margins of which are fixed down by stitches to the back of the stomach. of bowel, so as to prevent the escape of intestinal contents when the gut is opened ; but, of course, it is impossible to do the same to the stomach ; the latter viscus ought, therefore, to be thoroughly washed out with some dilute antiseptic, such as boric acid, before the operation com- mences. Sponges are also packed around the site of operation, so as to receive any fluid which may escape. 920 A MANUAL OF SURGERY If Wolfler's plan of simply suturing is adopted, two incisions about an inch long are made, one in the stomach and the other in the jejunum, involving at first only the serous and muscular coats. In the stomach it is made parallel to the great con- vexity, and about i^ inches from its lower edge, whilst in the jejunum the incision is longitudinal, and situated along the anti- m jsenteric border. Both of these wounds gape to such an extent as to allow of the union of the divided coats on the lower side by the insertion of a row of fine catgut stitches. The mucous mem- branes are then incised, and a row of catgut sutures is introduced to unite them to the same extent, the knots being located within the lumen of the bowel. The surgeon then deals with the remain- ing unconnected lateral and upper segments of the openings, taking up the mucous membranes and serous coats separately by a double row of stitches, the knots being placed on the outer aspect of the viscera. Thus, the deeper parts of the opening are scaled by what is known as Wolfler's suture (Fig. 332, p. 930), and the upper and more accessible portions by the Czerny- Lembert stitch (Fig. 330). If the Murphy button is employed, one of medium size should be selected, and it is introduced according to the rules given below (p. 938) for lateral anastomosis. The operation is completed by suturing the margins of the opening in the meso-colon to the stomach, so as to prevent any subsequent contraction, by cleansing the peritoneum, and closing the parietal incision in the usual way. The after-treatment consists in abstaining from stomach-feeding for at least forty-eight hours, if practicable, rectal alimentation being resorted to in the interval. Not unfrequently there will be some regurgitation of bile into the stomach, and this may lead to troublesome vomiting for a few days ; but if the junction is satis- factory, it soon passes off, especially when food is administered by the mouth, as may usually be undertaken on the third day. At first only fluid nourishment should be permitted, but in a week's time soft solids may be given, and gradually a more liberal diet is ordered. The effect of the operation is necessarily only palliative when cancer is present, but the general condition often improves considerably for a time, and the final exitus lethalis is associated with less suffering. In comparing Wolfler's and Murphy's methods, the great advantage of the former consists in its introducing no foreign body, which may give rise to trouble by slipping back into the stomach or by impaction lower down the gut ; hence it should always be used in non-malignant cases. The proceeding is, however, much more tedious, and the shock caused by the prolonged operation is often sufficient in itself to turn the balance against a patient whose powers have been considerably dimin- ished by a malignant growth associated with semi-starvation. ABDOMINAL SURGERY 921 Murphy's operation, though placing a solid body of some size within the intestinal canal, has the great advantage of rapidity, and, on the whole, we are inclined to recommend this proceed- ing as the better in malignant disease. The results hitherto obtained have been most encouraging, Murphy being able to report twenty-nine cases, with only eight deaths, and we our- selves have had several successful cases. The button, if all goes well, should appear in the motions about a fortnight after the operation. Ulcer of the Duodenum is occasionally met with after burns, as already described at p. 87. It may also occur in the same way as a gastric ulcer — i.e., more or less spontaneously, and without any apparent cause. The symptoms to which it gives rise are deep pain in the right hypochondrium, worse after food, together with vomiting. Haemorrhage may be caused by the ulcer laying open some branch of one of the pancreatico-duodenal vessels, and this may prove fatal. Perforation is sometimes induced, and, according to its situation and size, it gives rise to acute or chronic suppurative peritonitis, or, if it opens posteriorly, to a subphrenic abscess, which tends, however, to come to the surface to the right of the suspensory ligament of the liver ; in fact, the symptoms and results are very similar to those of perforating gastric ulcer (q.v.). Stenosis of the duodenum may follow this lesion. Affections of the Intestine. Congenital Conditions are occasionally met with affecting the intestines, and perhaps giving rise to serious complications. (a) The most common of these consists in what is known as Meckel's diverticulum. It occurs as an outgrowth from the lower end of the ileum, which may be patent for 1 or 2 inches, terminat- ing possibly in a fibrous cord, which floats free amongst the intes- tines, or may contract adhesions, and thus determine an internal strangulation ; sometimes it persists as an open tube as far as the umbilicus, giving rise to a congenital faecal fistula. It is due to non- obliteration of the omphalo-mesenteric duct, (b) Congenital stenosis of the duodenum also occurs opposite the entrance to the common bile-duct, and a similar condition may arise in the lower part of the ileum at a spot corresponding to the site of Meckel's diverticulum. Injuries of the Intestine. Contusion of the Intestine may result from any serious blow on the abdomen, and necessarily varies in its effects with the nature and force of the injury, the amount of distension of the gut, and the strength and power of resistance of the parietes. In its simplest form, it merely produces a little bruising of the intestinal 922 A MANUAL OF SURGERY wall, followed by a subacute or chronic enteritis, from which with care the patient quickly recovers. In the more severe cases, an acute enteritis ensues, due to bacillary invasion, which may even run on to ulceration or sloughing of the coats of the bowel. The latter result is more likely to follow if the mesentery has also been involved in the injury so as to produce thrombosis of the mesenteric vessels. Under these circumstances, the final issue depends largely upon the rapidity of the inflammatory pro- cess. If adhesions have had time to form between the parietes and the injured gut, the mischief is limited, and the patient may recover with an artificial anus or faecal fistula, the formation of which has been preceded by a localized intraperitoneal abscess, containing extremely offensive pus, owing to the presence of the Bac. coli, which has migrated through the intestinal wall. If, however, the inflammatory affection is rapid in its onset, and adhesions have not had time to develop, acute diffuse peritonitis is almost certain to follow. When the injured portion of the bowel is retroperitoneal, as in the duodenum or colon, a retroperitoneal abscess may form. The Symptoms of intestinal contusion consist primarily of shock and pain. The amount of shock varies necessarily with the severity of the injury and the nervous susceptibility of the patient. The pain may not be severe during the period of shock, but is always very marked subsequently, and increased by examina- tion, movement, or during violent respiratory efforts. To limit such movement, the abdominal parietes are maintained in a state of firm contraction, and can be felt hard and resistant. Vomiting may be present, but is not a marked feature. The later symptoms necessarily vary with the course taken by the case, and need not be described in further detail. Treatment is conducted along the same lines as that of contu- sions of the abdominal wall (p. 892), viz., where there is no absolute evidence of rupture, an expectant attitude must be adopted. If, however, at the end of twenty-four or forty-eight hours signs of acute peritonitis manifest themselves, an exploratory laparotomy is justifiable. Acute enteritis induces diarrhoea and the passage of blood-stained mucus, and such symptoms will indicate the use of bismuth, and perhaps a little morphia, whilst a fluid diet is alone permissible. Rupture of the Intestine follows abdominal injuries of a more severe character than those causing contusion, such as when a cart or cab has traversed the abdomen, or when the patient has been tightly squeezed. The amount of distension of the gut is a most important factor in the aetiology, since it is obvious that a distended coil is much more likely to give way than one that is empty ; in the latter case it is quite possible for a small wound to occur, through which the intestinal contents are unable ABDOMINAL SURGERY 923 to escape. The bowel does not always give way at the point of impact, but occasionally at a distance from it ; under these cir- cumstances the tear is more likely to be ragged and irregular, whilst if it yields at the point struck, the gut may be cleanly torn across. The parts most frequently affected by this form of injury are the junction of the moveable jejunum with the fixed duodenum, and the lower 3 feet of the ileum. The effect of the accident on the mesentery is also of importance, since in the first place it may give rise to considerable intraperitoneal haemorrhage, and later on may cause sloughing of the gut as a result of thrombosis. The Effects of rupture of the intestine are always extremely serious, if extravasation of the contents follows, since acute diffuse peritonitis is almost certain to be lighted up ; in a few cases a localized intraperitoneal abscess has been known to result, but such is by no means common. The early Symptoms consist of severe and usually lasting shock, accompanied by intense abdominal pain. Owing to escape of the intestinal contents, a virulent form of acute peritonitis follows immediately, from which the patient rapidly succumbs. Free gas is sometimes, but not frequently, met with in the peritoneal cavity, as in rupture of the stomach, and may be recognised by the existence of a resonant note on percussion in front of the liver. In a few cases emphysema of the abdominal walls has been caused, and in the absence of thoracic injuries or of diffuse cellulitis is an absolutely certain sign of rupture of the intestinal tube. Vomiting occurs, but not to an excessive degree ; if blood is found in the vomit, it suggests that either the stomach or upper part of the intestinal canal has been injured. Occasionally a blood-stained motion is passed, but only late in the case. The Diagnosis of a ruptured intestine is always a matter of uncertainty in the absence of such symptoms as resonance in front of the liver or emphysema of the abdominal walls, which are very uncommon. The amount of shock is an uncertain guide, although, if prolonged and severe, it is suggestive ; whilst the presence of an area of deep fixed tenderness and pain with, perhaps, a rigid abdominal wall over it, and the incidence of early acute peritonitis are probably the only signs that we can depend upon with any certainty. The history and nature of the accident are important, and should be carefully investigated. In the non-existence of any distinct signs of rupture, Treatment in the early stages can only be expectant, and directed towards combating the shock and relieving the pain. A small dose of opium should be administered with this object, and also to check peristalsis, and hinder further extravasation of the intestinal con- tents ; but as little as possible should be given, since it tends to mask symptoms. If the surgeon has good grounds for suspect- ing that the intestine is torn, he ought at once to undertake an exploratory laparotomy, which in careful hands will do less harm 924 A MANUAL OF SURGERY to the patient than waiting for the onset of acute peritonitis to make the diagnosis certain. If severe shock is present, an injec- tion of hot saline solution into a vein will sufficiently restore the patient in the majority of cases to warrant such a procedure. When a rupture is found, the same rules of treatment should be followed as those which have been enunciated for a ruptured stomach. In Punctures or Stabs involving the intestine, the results differ considerably according to the amount of distension of the bowel, as also with the fluidity of the faeces and the direction of the incision. Thus, a longitudinal cut (running parallel to the axis of the bowel) is more likely to gape than a transverse one, owing to the greater power of the circular muscle fibres ; a small puncture may be almost closed by a protrusion of mucous membrane. Wounds of the small intestine are more likely to be accompanied by extrava- sation than when the colon is involved, owing to the contents of the former being in a much more liquid state. The Symptoms are very similar to those already detailed as characteristic of rupture of the intestine. As far as regards the immediate phenomena, there is nothing absolutely typical unless gas or faecal material is escaping either from the abdominal wound or from a prolapsed portion of bowel. Shock is not necessarily so severe as when the intestine is ruptured by violence without penetration ; abdominal pain is always present, and the pheno- mena of acute peritonitis quickly follow. Treatment. — Every case of suspected penetration should be carefully and thoroughly explored ; a probe is first passed, and then the abdominal parietes divided on either side of the probe, so as to enable the extent of the mischief to be ascertained. If the peritoneum is not opened, no harm has been done, since after purification the different layers of the wall are sutured together. If the peritoneum has been involved, the opening in it should be enlarged, so as to explore the viscera and determine with certainty whether or not the gut has been wounded. If a small punctured or incised wound of the intestine is present, it is closed by a purse-string stitch or by a row of Lembert or Czerny- Lembert sutures. If a more extensive lesion exists, excision of the damaged portion may be necessary ; but if the patient is deeply collapsed from the supervention of peritonitis, it may be wiser to bring the divided ends to the abdominal wall, and form a tem- porary artificial anus, which is subsequently dealt with when the patient's general condition has improved. As to the treatment of the resulting peritonitis, we must refer to what has been written concerning rupture of the stomach (p. 902). For Gunshot Wounds and their treatment, see pp. 203 and 205. ABDOMINAL SURGERY 925 Perforation of the Intestine arises from many different causes, such as the impaction of a foreign body, or the yielding of an intestinal ulcer, as occurs in tuberculous disease or typhoid fever, or from that form of enteritis which follows strangulated hernia. We have already discussed the phenomena resulting from the perforation of an ulcer of the stomach or duodenum (pp. 905 and 921), and another variety caused by perforation of the appendix will be alluded to subsequently (p. 947). When the jejunum or upper portion of the ileum is involved, perforation is usually due to the impaction of a foreign body, such as a fish-bone, or to yielding of a tuberculous ulcer. In acute cases, general peritonitis is almost certain to follow, and what we have written as to the results and treatment of such a lesion in the stomach applies here with equal force. Occasionally the lesion is of a more chronic type, especially when due to tubercle, and then adhesions may form, allowing an intraperitoneal abscess to develop, and should it open externally, a faecal fistula follows. In not a few cases the process of cicatrization may lead to a spon- taneous closure of the fistula, and no operation should be under- taken until sufficient time has elapsed to determine whether or not this will occur. A similar condition sometimes results from tuberculous peritonitis, the umbilicus being a common site for such a fistula to develop. In other cases several coils of intes- tine may be matted together by adhesions, amongst which an abscess forms, and this by opening into the bowel in two or more places gives rise to a fistulous communication, known as a fistula bimucosa. In the lower portion of the ileum, typhoid fever is the most usual cause of perforation. It generally occurs about the end of the second or in the third week of the disease, and rarely more than one perforation is present. It is most commonly seen in bad cases associated with meteorism and haemorrhage, but is not limited to such. The symptoms are usually those of sudden collapse, as indicated by a falling temperature and a quick and feeble pulse, whilst severe and persistent abdominal pain followed by distension indicates the development of general peritonitis. Even when the patient is already collapsed by the disease, some slight fall of temperature with acceleration of the pulse may occur, followed by abdominal pain and meteorism. Early rigidity of the belly w r all is an important diagnostic sign, whilst there may be some irritability of the bladder. The only treatment which holds out any prospect of saving the patient is operation, but owing to his depressed condition the outlook is not particularly bright. Obviously, when he is moribund, it is useless to interfere ; but the fact that at least seven cases of recovery have been reported, out of rather more than forty that have been subjected to operation, shows that in suitable circumstances a certain percentage of success may be anticipated. The abdomen should be opened in 926 A MANUAL OF SURGERY the middle line below the umbilicus, and if the lesion is not at once obvious, the ileum is sought for at its junction with the caecum, and the bowel brought up and carefully examined inch by inch till the perforation is found ; it may then either be closed by sutures, or stitched to the margins of the wound so as to create a temporary artificial anus. The peritoneum is cleansed and drained in the usual way. In the large intestine the most common cause of perforation is ulceration due to chronic obstruction. Masses of faeces accumu- late within the bowel, and by their pressure give rise to inflam- mation of the walls, which runs on either to ulceration or to actual necrosis. Most usually the peritoneum is by this means laid open, and acute perforative peritonitis follows. In malignant disease of the colon, perforation also occurs in some instances, giving rise to a localized abscess, and subsequently to a faecal fistula. Stenosis of the Intestine. This arises from two main causes, viz., the contraction of cicatrices, and the development of malignant growths. Cicatricial Stricture usually results from the healing of ulcers which have extended more or less circularly around the bowel. After typhoid fever they are therefore rare, since the ulcers are rather longitudinal than transverse, and, indeed, there is only one certain case of stricture arising from this source on record. In the small intestine tuberculous ulceration is one of the commonest causes, since it always tends to travel round the gut along the line of the vessels ; it is usually found in the neighbourhood of the ileum, and may involve an extensive portion of the bowel, or be multiple. It also arises from syphilitic disease, or as a sequela of strangulated hernia, injury, or the separation of an intussus- ception. In the large intestine dysentery is perhaps the most important cause of stricture, whilst syphilis or pelvic cellulitis may determine its occurrence in or near the rectum. Owing to the contents of the small intestine being of a some- what liquid nature, a stricture in this situation often exists for some time before symptoms of any urgency arise. The patient may complain of a certain amount of indigestion and discomfort, but sooner or later the narrowed aperture of the gut becomes blocked either by a fold of mucous membrane or by a portion of undigested food, and thus an attack of obstruction is induced. In the early stages of the disease this can be overcome and remedied by purgatives, but each recurrence is likely to increase in severity, until finally an acute attack supervenes, which kills the patient, unless relieved by prompt surgical interference. In the large intestine very similar phenomena appear, but the attacks of obstruction are of a somewhat different character, since there is less pain and vomiting ; and aperients, instead of re- ABDOMINAL SURGERY 927 lieving the patient, as they often do in the earlier attacks in the small gut, always aggravate the symptoms ; there is also much greater distension of the abdomen. The diagnosis of stricture, though strongly suggested by the symptoms, can only be abso- lutely confirmed by an exploratory operation, except when the lower part of the rectum is involved. The Treatment in the earlier stages consists of suitable dieting, and the administration of purgatives, or of large enemata, and for a time such will be successful. Sooner or later, however, a more than usually serious attack of obstruction will call for something more radical, and we must refer readers to the chapter on obstruction for details of the treatment to be adopted. If on operating the stricture is found and recognised, enteroplasty or enterectomy should be undertaken, if the small gut is involved. For stricture of the caecum or ascending colon, some short- circuiting method, whereby the ileum is implanted into the colon below the stricture (ileo-colostomy), is perhaps the best plan to adopt ; in the transverse colon excision is possible, as also in the sigmoid flexure, whilst in the descending colon enteroplasty may be undertaken. Failing any of these radical measures, the establishment of an artificial anus in the bowel above the stenosis suffices to give relief. It must be remembered, however, that no permanent opening can be made more than a foot above the ileo- cecal valve, since the absorption of nutrition is thereby so inter- fered with that death from asthenia is certain to follow in a very short time. The intestinal contents, too, are fluid and very acid at this level, and give rise to much irritation of the skin. Cancer of the Bowel is almost always primary in nature, and is then usually a columnar carcinoma, to which colloid degenera- tion is sometimes added. Secondary growths are occasionally met with, and are necessarily of the same nature as the original tumour. The disease may occur as a localized plaque imbedded in the mucous membrane, and undergoing the usual ulcerative changes ; but more frequently it appears as a circular infiltration of the bowel. Secondary deposits arise after a time in the mesen- teric glands, the liver, or even in distant parts ; the general history of these growths suggests, however, that they are not so malignant in type as cancer elsewhere. At first they merely give rise to dyspeptic Symptoms of varying character, according to the size and situation of the mass, and then to these may be superadded intermittent attacks of chronic or subacute obstruction, which originally come under the care of the physician, but at length the surgeon's assistance is needed to relieve or deal with an acute attack. Two other manifestations of the disease may determine surgical action, viz. : (1) The existence of a tumour, which, though at first readily moveable, soon becomes fixed owing to the formation of adhesions to surrounding tissues ; and (2) the development of an abscess due to an invasion of the growth by 928 A MANUAL OF SURGERY the Bac. coli, which finds its way through the ulcerated surface of the tumour. This complication is most likely to occur when the colon is affected, and all the manifestations of an acute or sub- acute intraperitoneal abscess supervene. In favourable cases it bursts externally, or is opened, giving exit to exceedingly offensive pus, and for a while the patient's symptoms are relieved ; a fiscal fistula follows, and the disease runs a rapid course to its inevitably fatal issue. Treatment. — Whenever a diagnosis of malignant disease of the bowel has been made or is suspected, an exploratory laparotomy is justifiable in order to confirm or disprove the fact. Unfor- tunately, physicians are only too liable to leave the case until the progress of the disease has settled the question, and then palliative treatment may alone be possible. If found early enough, the growth, together with a good margin of healthy tissue on either side, should be removed, and the intestinal canal re- stored by enterorrhaphy. A V-shaped portion of the mesentery is included in the part excised, so as to remove if possible any affected lymphatic glands. Should this be impracticable owing to the extent or fixity of the growth, the following plans of treatment may be considered, and that which best suits the requirements of the particular case undertaken : i. The growth may be short-circuited by uniting portions of gut above and below it. This is usually accomplished by one of the forms of lateral anastomosis described hereafter ; thus, the caecum may be attached to the sigmoid flexure in a case of cancer of the transverse colon. 2. The bowel may be entirely divided above the tumour, and the upper end implanted into the gut below it, the lower end of the divided bowel being sutured. This lateral implantation is the best plan of treatment to employ for cancer of the caecum which cannot be extirpated ; the ileum is divided above the valve, and its open end implanted into the ascending colon well above the growth (ileo-colostomy), whilst the lower end is totally closed. 3. The affected coil of gut has been excluded from the intes- tinal tube by dividing the bowel above and below, and uniting the divided ends, whilst the open ends of the diseased coil are either entirely closed by sutures, or one end is closed and the other is brought to the surface, and fixed there so as to establish a fistulous track. The latter practice is probably the safer to adopt, since there is always a certain amount of discharge from the cancerous growth, and, at any rate, in the small intestine the mucous membrane itself secretes, so that total closure would be accompanied by danger. 4. Finally, if none of these measures are applicable, or if the patient's condition is such as to make it unwise to attempt them, and if the growth is situated in the colon, an artificial anus may be established. ABDOMINAL SURGERY 929 Operations on the Intestines. Before describing in detail the actual operations which are undertaken upon the small or large intestine, it is essential that the various Sutures employed in such work should be discussed. The interior of the bowel is occupied by material which, as long as it remains in its proper place, is innocuous enough ; but let it once find its way into the peritoneal cavity, an acute and often fatal peritonitis is almost certain to follow. Hence, every union made by the surgeon must be air- and water-tight, and capable of accommodating itself to varying degrees of intra- intestinal pressure. For this reason a continuous stitch must never be employed except in the long axis of the bowel, or unless there is some button or bobbin within it. Again, it is essential that on its peritoneal aspect the line of union should present nothing but serous membrane, as otherwise adhesions are certain to form, and the comfortable action of the bowel will be Fig. 328. — Lembert's Suture as applied for a Longitudinal Wound of the Bowel. The stitches are carried well beyond the ex- tremities of the incision, so as to obliterate the groove always caused by this method of suturing. Fig. 329. — L emberi's Suture seen in Section, to show Character of Approximation. I., Suture ; a, serosa ; b, muscularis ; c , mucosa. subsequently impaired. Hence, special forms of stitches have to be adopted, the more important of which are described below. Laiiberfs Suture, originally proposed at the end of last cen- tury, has for its object the bringing of surfaces of peritoneum together without encroaching on the mucous membrane ; any stitch which involves the whole thickness of the wall is liable to be followed by leakage of the intestinal contents, and possibly peritonitis. The needle is passed at right angles to the axis of the wound through a small fold of the serous and muscular coats, going down to the submucosa ; each fold is placed about one- twelfth of an inch from the margins of the incision (Fig. 328). On drawing up and tightening the stitch, the margins of the wound are tucked in (Fig. 329), and only the serous coats brought into apposition. A series of similar stitches are inserted along the whole extent of the wound, numbering about ten or twelve to the inch. In closing a longitudinal incision in this way, a groove will be formed at either end which must be obliterated by two or 59 93° A MANUAL OF SURGERY three extra sutures. For a small puncture the same type of stitch is utilized, but it may be introduced circularly around the opening like a purse-string, and by tightening it the margins of the aperture are turned in and buried. The Czerny-Lembert Suture is very similar in its nature, but consists of two rows : the first has for its object the closure of the wound in the mucous membrane (Fig. 330, I.), and in a h c Fig. 330. — Czerny-Lembert Suture. I., Stitch securing divided mucous membrane; II., ordinary Lembert suture, for the serous coats ; a, serosa; b, muscularis ; c, mucosa. Fig. 331. — Halsted's Mattress Suture. longitudinal wound this may be of the continuous type ; the second row consists of the ordinary Lembert stitches, con- tinued or interrupted according to the requirements of the case (Fig. 330, II.). By this means the knots of the first series of sutures are covered over and buried by the second row. Halsted's Mattress Suture (Fig. 331) is a very valuable one, Fig. 332. — Wolfler's Suture. , Stitch through serous and muscular coats applied and tied from within ; II., stitch uniting divided mucous membrane over the former, so as to cover it in ; a, serosa ; b, muscularis ; c , mucosa. Fig. 333. — Paul's Tubes (Glass), Large and Small Sizes. and constantly utilized. It consists practically of a double Lembert, a loop being thus formed at one end, whilst the knot is tied at the other. It is introduced with exactly the same pre- cautions as the original Lembert. Occasionally it happens that two segments of bowel have to be stitched together, although the surgeon cannot reach the outer coats owing to this portion being fixed. Thus, in dealing with the posterior segments of the walls of the bowel, either in pylorectomy or gastroenterostomy, it is found that one can only work from the front, and the stitches must then be inserted by ABDOMINAL SURGERY 931 what is known as Wolfiey's Method (Fig. 332). The sutures are first passed through the serous and muscular coats on either side (I.), the knots being tied on the inner aspect — i.e., towards the lumen of the open gut. The mucous membrane is then secured by a second row of stitches (II.), so as to cover over the first series of knots. Of course, only a portion of the circum- ference of the bowel has to be dealt with in this way ; as soon as possible, one changes to the Czerny-Lembert method. Passing on now to the actual operations, the following have to be described : 1. Enterotomy is a term which is only correctly applied to an incision made into the intestine either for the removal of a foreign body or for the examination of its interior. The wound should always be placed in the longitudinal axis of the gut, and along its anti-mesenteric border ; it is closed by a row of Lembert, Czerny- Lembert, or Halsted stitches. 2. Enterostomy, or the formation of an artificial opening into the bowel, is an operation sometimes undertaken for the relief of intestinal obstruction when the patient is almost moribund, and one is unable to make an exact diagnosis of the cause. It is especially useful when the obstruction is probably due to some lesion located in the caecum or ascending colon. An incision is made, either in the middle line or in the iliac region on the right side, somewhat similar to that employed for removal of the appendix ; the first distended coil which presents is drawn well out, and opened after carefully protecting the peritoneal cavity from faecal infection. A large trocar and cannula are first introduced, so as to allow the flatus and fluid contents of the gut to escape ; the opening is then enlarged and a Paul's (glass) tube tied in (Fig. 333), so as to carry away the intestinal contents clear from the wound, to the margins of which the bowel is fixed. This proceeding is sometimes known as Nelaton's operation, and is at the best merely a temporary expedient. 3. Enteroplasty is a plan of treatment which has been devised for dealing with cicatricial strictures of the intestine, and is based on the same idea as the operation of pyloroplasty for fibrous stenosis of the pylorus (p. 917). A longitudinal incision is made through the stenosed gut along the anti-mesenteric border ; this is opened out, and converted into a transverse cleft, which is care- fully sutured, the lumen of the bowel being thereby considerably increased. 4. Enterectomy, or excision of a portion of the bowel, is required in the following conditions : (a) For the removal of gangrenous gut after strangulation, whether internal or external ; {b) in the treatment of multiple penetrating wounds, as after a stab or gun- shot injury; (c) in dealing with an artificial anus or faecal fistula; (d) for the removal of simple or malignant strictures ; and (e) in some cases of intussusception. Not long ago the operation was 59—2 932 A MANUAL OF SURGERY but rarely undertaken, and the results were most unsatisfactory; but at the present time a very considerable degree of success may be expected, and enterectomy is frequently practised. Naturally, the results vary largely with the condition for which it is per- formed, and with the experience and skill of the operator ; a much higher rate of mortality follows when the excision is done for malignant disease, for gangrene following strangulation, or for intussusception, than when performed for other causes. Whenever practicable, the bowel should be thoroughly emptied prior to operation, and rendered as sterile as possible by the use of such drugs as calomel (gr. i. daily), salol, /i-naphthol, naphtha- lene, bismuth subnitrate, etc., for a few days previously. The abdomen is opened by any suitable incision, and the portion to be removed clearly defined, the general peritoneal cavity being pro- tected by a careful packing with sponges or gauze. The bowel must then be clamped on either side of the seat of operation, so as to prevent the escape of intestinal secretions or faeces. Any of the forms of clamps figured in surgical instrument catalogues will effect this purpose, and amongst the best are Makins' or Lane's ; but perhaps it is wiser to do without them, the same result being obtained by passing a piece of drainage- tube through the mesenteric attachment, and tying or clamping it around the gut. The affected portion is now removed by scissors, cutting through the bowel and taking away a V-shaped portion of the mesentery, after securing as far back as possible the main nutrient vessels to the diseased area, according to Murphy's recommendation. It must be remembered that the terminal vessels run circularly round the gut, and have but little lateral anastomosis, and therefore it is desirable that the incisions should slightly diverge from the mesen- teric attachment, otherwise the projecting edge of the anti-mesen- teric border is certain to slough, and septic peritonitis will result. Some operators recommend that the mesentery should not be cut into, but that the gut should be detached from the mesenteric junction ; such practice will suffice when merely a small segment of bowel is to be removed ; but if a large portion needs resection, it would take a much longer time to secure all the bleeding spots. The wound in the mesentery is subsequently secured by sutures, and the divided ends of the bowel united by one of the many forms of enterorrhaphy described below. 5. Enterorrhaphy is required for any condition in which there is a solution of continuity of the canal, and necessarily the methods employed must vary according to the character and situation of the lesion. We have already alluded to the plans that are utilized in dealing with longitudinal wounds of the gut. The two chief methods that remain to be discussed are the end-to-end union of a totally divided segment of the bowel, and the means whereby lateral approximation or union is secured. A BDOMINA L SURGERY 933 For end-to-end union the following are the chief plans that have been adopted : A. Enterorrhaphy by simple suturing. In this the surgeon utilizes no special apparatus, but trusts to the deftness of his fingers and the accuracy of his stitches. The gut is united by a series of interrupted Lembert or Czerny-Lembert sutures, in- serted around the circumference at distances of about one-twelfth of an inch. The greatest care must be employed in dealing with the mesenteric attachment, where the peritoneal layers separate in order to enclose the bowel, and where there is a consider- able likelihood of the muscular coat being missed ; if this happens, leakage is almost certain to ensue. This method in skilled hands is very satisfactory in its results, but there is one great objection to it, viz., the time taken in its performance. Fig 334. — Maunsell's Operation I for uniting divided segments of Gut Fig. 335- — Maunsell's Operation. The mesenteric and anti-mesenteric Taction stitches carried through the traction stitches have been intro- ? u ° e . and out of the lateral P en " duced, and A shows the situation of in S- the lateral incision, and its forma- tion by transfixion. B. Maunsell's opevation, in which a temporary invagination enables the coats of the gut to be accurately sutured together, is a most valuable proceeding. It may be described in stages as follows : (a) Two long horsehair sutures are passed through the whole thickness of the mesenteric and anti-mesenteric borders of each end of the divided intestine, and tied together with the knots on the inner aspect of the bowel (Fig. 334). (b) A longitudinal incision about three-quarters of an inch in length (Fig. 334, A) is then made through the anti-mesenteric border of the bowel, about an inch from the end of the upper or lower segment, according to convenience, (c) The horsehair sutures (Fig. 335, D) are now passed within the intestine, and drawn out of the lateral opening. Traction upon these, assisted by a little careful manipulation, enables the surgeon to produce an artificial intussusception (Fig. 336). Difficulty may be experienced in this if the lateral opening has been placed too far from the section, or if the mesentery is loaded with fat or very oedematous. The divided A MANUAL OF SURGERY 934 ends of the bowel now present through the lateral aperture as two tubes one within the other (Fig. 337), their serous coats being in contact, and the mucous coats lining both the inner and outer aspects of the protrusion. (d) A sharp straight needle (Fig. 337, A) carrying after it a thread of fine silk or cat- gut, is passed through one of the diameters of the protrusion, transfixing the serous, muscular, and mucous coats. The central portion of the suture, as it passes across the inner tube, is drawn out and divided, and the two halves are tied on either side. Similar sutures are passed in other diameters, until some sixteen or more are present. By this means the two tubes are securely united together, (e) All the sutures are cut short, and the intussusception reduced. The bowel will be found Fig. 336. — Maunsell's Operation, showing Position of Intestine after Invagination has been accom- plished. The dotted lines indicate the mucous membrane ; the continuous lines, the serous. Fig. 337. — Method of insert- ing Stitches in Intestine in Maunsell's Operation. A shows the needle passed through both sides of the bowel, and through all the intestinal coats, so that one passage of the needle places two sutures. accurately sutured (Fig. 338, A), the knots of all the stitches being placed within the lumen of the gut. (/) The lateral opening in the bowel (Fig. 338, B) is closed by a continuous row of Lembert's sutures, and if need be a row of the same is inserted around the circular junction, as an additional safeguard in order to bury the penetrating stitches, and so prevent leakage. The operation can be rapidly performed, and gives excellent results. Should it be necessary to unite unequal portions of intestine, the larger segment is first reduced in size by the insertion of a row of Lembert's or Czerny-Lembert's sutures, so as to make the opening correspond in size to that of the smaller ; invagination may then be accomplished through a lateral opening in the larger portion, and the operation completed as before. A modification of this method has been recently suggested and practised with success by Ullman. After the invagination through the lateral incision has been accomplished, a hollow bobbin made of decalcified bone or carrot, and with a circular groove around its ABDOMINAL SURGERY 935 middle, is inserted into the inner canal, lined by mucous mem- brane (Fig. 339). Around this the two tubes of gut are firmly tied by a single silk thread. The intussusception is now reduced, the bobbin being drawn into the bowel, and the operation is completed by closing the lateral opening. The bobbin retains its shape and Fig. 338. — Maunsell's Opera- tion COMPLETED AFTER THE IN- VAGINATION HAS BEEN REDUCED. A shows line of union with serous coats turned well in, so that none of the sutures appear outside ; B, longitudinal incision stitched up. Fig. 339. — Ullman's Modification of Maunsell's Operation. A bobbin is seen in place in the centre of theinvaginated canal, and a single suture, S, secures it in position. texture sufficiently long to enable the segments of the intestine to become firmly united by plastic lymph. If further use confirms Ullman's experiences, we shall have in this method a most valuable addition to our means of obtaining rapid and secure end-to-end union. Full Scze A, Male half; B by c, spring A P" B Fig. 340. — Murphy's Button. female half ; P, inner cup or flange of male half, governed ; S, spring catches working along a screw thread on the inner aspect of the central stem of the female half. C. Enterorrhaphy by the use of special apparatus. Under this heading various bobbins and Murphy's button must be included. Murphy s Button is represented in Fig. 340. It consists of two portions, a male and a female, which can be easily insinuated one into the other and closed, but which can only be separated by un- twisting, the spring catches (S) seen in the side of the stem of the 936 A MANUAL OF SURGERY male working along a screw thread in the interior of the female. Each half consists of a central stem, which is hollow for the passage of faeces, to the outer end of which is attached a cup-shaped expansion. In the male half there is an additional inner cup or flange (P), separated from the former by a spring (c), so that when the two halves are approximated, the inner cup is kept constantly pressed against the female half, and thus pressure- atrophy of the tissues grasped between the two segments results, ultimately setting the button free. In the meantime, however, a sufficient formation of lymph will have oc- curred along the line of junction of the two to prevent extravasation and to secure union. In performing end-to-end anastomosis, a running thread is inserted through each end of the divided intestine in the manner shown in Fig. 341. It commences at the anti- mesenteric border (b), and traverses the whole thickness of the gut two or three times until it reaches the mesentery (a), when a return overstitch is introduced so as to gather without fail the two layers of the mesentery into the grasp of the button. The same stitch is continued along the opposite side of the tube, and brought out again at the anti- mesenteric border. A half-button is now and two ends of introduced into each end of the divided gut, suture; c, mesenteric and preferably the heavier male end into attachment. ftie lower segment ; the stitch is then drawn tight and tied, so as to gather up the gut wall round the central stem of the button (Fig. 342). The two halves are now pressed together (Fig. 344), sufficient force Fig. 341. — Method of inserting Suture for End-to-End Anastomosis with Murphy's Button. a, Overstitch mesenteric b, anti- border DOWN BROS LONDON Fig. 342. -Appearance of Intestinal Segments with Murphy's Button Tied in. (Down Brothers.) being employed to bring the walls of the gut into accurate apposi- tion, but without exercising injurious pressure. The button is generally set free about the seventh day, and ABDOMINAL SURGERY 937 should pass downwards, and be expelled with the faeces any time from the fourteenth to the twenty-first day. Occasionally there are difficulties in the onward passage of the button, which may either be retained entirely, or may become impacted ; under these circumstances it has been known to ulcerate through the walls of the gut, and cause fatal peritonitis. The results of the operations undertaken by means of the button are very satisfactory, as com- pared with ancient statistics ; but it is doubtful whether they are any better than those obtained by many of the methods intro- duced more recently. The one great advantage of this appliance is the rapidity with which the anastomosis is completed. There are, however, several very grave objections to its employment as a routine measure ; the fact of its being made of metal is of itself a drawback, and fatal issues have certainly occurred from slough- ing, from want of union due to the use of too large a button, or of one badly constructed, and even from subsequent obstruction and perforation when it has passed lower down. On the whole, one would be inclined to use it when time is of value, and the patient's general condition such as necessitates the utmost speed in operating ; under other circumstances one would prefer some other method. Many other useful contrivances, such as Mayo Robson's bobbin (Fig. 343), Allingham's bobbin, Chaput's button, etc., have been introduced of late, and with most of them good results can be obtained. The majority consist of a hollow tube of decalcified bone made of different sizes to fit the varying lumen of the gut. The object is not so much to bring about apposition of the divided ends of the bowel as to act as an internal splint, steadying the part during and after the operation, facilitating thereby the introduction of the stitches, and shielding the line of union from the irritation of faeces for some days. Mr. Robson recommends that two continuous sutures should be employed, one to unite the divided ends of the mucous membrane, and the other to approximate the serous and muscular coats. It will be found advantageous to have a curved needle at each end of these. The sero-serous suture is first introduced for the posterior half of the incision, each stitch taking a firm grip of the sero-muscular coats up to about a centimetre from the margin. The muco-mucous suture is then put in for the same extent. The bobbin is now placed in position ; the muco-mucous suture is first finished and tied, and finally the anterior half of the sero-serous suture is similarly completed. Each of these sutures must be firmly tied around the bobbin, so that no slipping is possible. The material of which it is composed (decalcified bone) is such as to Fi g. 343. — Mayo Robson's Bobbin. (Down Brothers.) 938 A MANUAL OF SURGERY do no subsequent harm to the mucous membrane, since it becomes soft and pulpy in the course of a few days. 6. Lateral Anastomosis of the intestine is usually undertaken in order to effect the short-circuiting of some malignant growth, or of a stricture which cannot otherwise be dealt with. It is some- times employed instead of end-to-end anastomosis to unite divided segments of intestine. The open ends are first entirely closed by Lembert or Czerny-Lembert stitches, and the portions of bowel made to overlap. Corresponding lateral incisions are then made into each. The anastomosis may be effected in the following ways : (a) By Simple Suturing, or, as it is sometimes called, by Wolfler's operation. This has been already described under gastroenteros- tomy at p. 920. The longitudinal openings in the two portions of bowel lying exactly opposite each other are secured by sutures, inserted in the posterior half of Wolfler's plan, and in the rest of the opening by the Czerny-Lembert method. In order to prevent subsequent contraction, it is absolutely essential that the mucous membrane be continuous all round the aperture. (b) Murphy's Button is probably the quickest, and certainly the most satisfactory, of all the plans that have yet been suggested. The details of its insertion differ slightly from those employed in effecting an end-to-end anastomosis. Incisions are made in the two sections of bowel to be united, each incision being two-thirds of the diameter of the button to be used. The wounds at first only involve the serous and muscular coats. A purse-string suture is inserted round the incision, traversing the whole thick- ness of the intestinal walls ; the mucosa is then incised, and the half-button introduced. By drawing the stitch tight and tying it around the stem of the button, the wall of the gut is gathered into the hollow of the cup. This is accomplished on each side, and then the halves of the button are pressed together in the way shown in Fig. 344. Murphy recommends that after the operation the bowels should not be confined, but should be kept loose, so as to prevent any solid mass of faeces blocking the channel through the button. (c) A Robson's Bobbin may be employed, the sutures being applied in exactly the same way as for end-to-end anastomosis. 7. The establishment of an Artificial Anus has frequently to be undertaken in cases of intestinal obstruction, where the onward passage of faeces is prevented by some irremoveable barrier. It is sometimes required in the treatment of intussusception, and for rupture or penetrating wounds of the gut. When the small intestine is involved, enterostomy may be undertaken as described above (p. 931); but it must be noted that life is impossible for any length of time with an artificial anus situated more than a foot above the ileo-caecal valve, on account of the interference with nutrition owing to cutting off such a large ABDOMINAL SURGERY 939 extent of absorbent mucous membrane. Some form of short- circuiting operation, or some means whereby the continuity of the bowel is restored, must therefore be subsequently undertaken. Things are, however, different in the large intestine ; colotomy is frequently employed in dealing with diseases of the lower bowel, and is an extremely successful proceeding. The character of the artificial anus varies considerably accord- ing to whether or not it is intended to be a permanent condition. If merely a temporary opening is required, the smaller the portion of bowel secured to the parietes the better, since the subsequent operation for its closure is so much simpler (Fig. 345). But Fig 3^ . — Method of closing Murphy's Button in Lateral Anasto MOSIS BETWEEN GaLL-BlADDER AND DUODENUM (DOWN BROTHERS.) where a permanent aperture has to be established, the surgeon's aim should be to totally deflect the course of the faeces ; and hence it is desirable to entirely withdraw a portion of the gut from the abdominal cavity, and to cut away a complete segment, including also, if possible, a portion of the mesentery. By this means the upper and lower openings are brought to the surface of the skin, and separated from one another by an area of cicatricial tissue representing the section of the mesentery (Fig. 346). Colotomy, or, as it should be correctly termed, ' colostomy,' is an operation for the establishment of an artificial anus in some portion of the large intestine. Any part of the colon may be thus dealt with through a median laparotomy ; but one usually prefers 940 A MANUAL OF SURGERY to open the termination of the descending colon through the peri- toneum in the left iliac region. Formerly the favourite method was to open the descending colon in the left loin behind the peri- toneum (left lumbar colotomy or Amussat's operation). Callisen's name has also been associated with this proceeding, but he merely proposed to do it through a vertical incision ; Amussat was the first to perform the operation, utilising a transverse incision, and extending its applicability to both sides of the body. Uses of Colotomy. — The operation is required under the following conditions: (i) For congenital absence of the rectum, when a perineal incision has failed to discover it ; (2) for chronic obstruc- tion of the large intestine, which cannot be relieved by enemata '"'-'-' :-. "\ :■'"' ({ X"' > )■ I • «ESfju .. '\«W \ ,&: \ *A^ Fig. 345. — Diagram of Temporary Fig. 346. — Diagram of Temporary Colotomy, showing the Single Colotomy, showing the Two Opening on a level with the Openings separated one from Skin, the passage to the Lower the other by a section of the Bowel being merely blocked by Mesentery. A SPUR OF MUCOUS MEMBRANE. ^ ^^ ^^ indicates the amount of Bowel cut away ; but, of course, such an extensive resection is only practicable when there is a very long mesentery, which is un- usual . or medical means, such as that arising from simple or malignant stricture, or from the pressure of pelvic tumours ; (3) for carcinoma of the rectum or sigmoid flexure, whether obstruction is present or not, if a radical operation is impracticable, or as a preliminary to excision ; (4) for some cases of syphilitic and other forms of ulceration of the large bowel, which cannot heal as long as they are irritated by the passage of faeces ; (5) for irremediable cases of recto-vesical and recto-vaginal fistula, whatever their origin ; (6) for volvulus of the sigmoid flexure, the inguinal operation being needed, not only to relieve the obstruction, but also to prevent recurrence. ABDOMINAL SURGERY 941 The ascending colon is occasionally opened in cases of mem- branous or ulcerative colitis in order to prevent the irritation caused by the passage of faeces over the inflamed tissues. The result, however, is somewhat unpleasant, in that the contents of the bowel at that level are usually fluid and very acid, giving rise to much local irritation. Lumbar Colotomy. — We shall here merely describe the operation as performed on the left side of the body. The patient lies on the right side, with a sandbag beneath the loin, so as to increase the space between the last rib and the crest of the ilium. The position of the colon is indicated by a vertical line drawn upwards from a point half an inch behind the centre of another line, passing from the anterior to the posterior superior iliac spine. The centre of the incision should correspond to this line mid- way between the last rib and the crest of the ilium. It should be made parallel to the last rib, and for practical purposes may commence at the outer border of the erector spinas, and pass outwards for about 4 or 5 inches (Fig. 375, A, p. 1068). This incision is carried through the layers of the abdominal muscles, dividing the latissimus dorsi and a small portion of the external oblique, and beneath this the posterior attachments of the internal oblique and transversalis muscles, constituting the fascia lumborum. This should be cleanly divided along the whole length of the incision, the last dorsal nerve and first lumbar artery being usually included. The sheath of the quadratus lumborum is opened, and the outer fibres of the muscle notched, if necessary. The deeper portions of the wound are now held apart by spatulas, and the loose fatty subperitoneal tissue gently torn through with the fingers and forceps ; it varies considerably in amount and con- sistency. The gut must then be looked for, and may be readily re- cognised, if distended ; but if collapsed, a good deal of difficulty is often experienced, though the hand of an assistant pressing back the anterior abdominal wall may bring it into view. It is well to define the lower edge of the kidney by the fore-finger, and the portion of gut lying immediately in front of it is usually the colon. In other cases it may be made evideni by inflating the rectum with air. In about 20 to 30 per cent, of individuals a true peritoneal ascending or descending meso-colon exists, and under such cir- cumstances it is necessary to open the general peritoneal cavity in order to bring the required portion of gut into view ; the opera- tion is then completed in the same way as for iliac colotomy, the bowel not being opened for some days if possible. When, however, the gut has only a partial serous investment, the peritoneal reflections are carefully defined, and the uncovered portion drawn upwards between the fingers into the wound. The highest attainable segment of gut should be selected, so that no loose or slack part may remain above the wound, to give rise later on to prolapse. If possible, the bowel should be left for a 942 A MANUAL OF SURGERY day or two before being opened, and is secured to the skin by sutures which merely pass through the muscular coat. The horns of the incision are then closed, and the gut incised at a later date. If, however, the patient is suffering from obstruction, and an immediate opening of the bowel is desirable, the best plan to adopt is to pull the gut well out of the wound, which is then carefully guarded by an antiseptic compress, and to tap it with trocar and cannula, subsequently making a small incision into it, in which a Paul's tube is at once tied, so as to allow the intestinal contents to escape without soiling the wound. A few fixation stitches are then introduced into the walls of the bowel, so as to prevent it from retracting. The tube is probably set free about the fourth day, but by this time the wound will be in such a state that no great harm will come from the escape of faeces in the neighbourhood. If a Paul's tube is not to hand, the patient is rolled over on to his back, and a large trocar and cannula inserted, so that the first gush of flatus and fluid faeces may be clear of the wound. On removing the cannula the mucous membrane of the gut is stitched to the margin of the skin, whilst the anterior portion of the incision is sutured, and the small cavity behind the gut packed with gauze. By fixing the bowel as far back as possible, this cavity will be diminished in size. An antiseptic dressing is then applied over a piece of protective to the anterior portion of the incision, and a pad of tenax is placed behind to receive the faecal discharge. Lumbar colotomy is not much in favour at the present day. It is always a difficult proceeding if the bowel is not distended ; and if an immediate opening is necessary, there is a considerable risk of suppuration of the wound and cellulitis. It has been almost entirely replaced by the iliac operation. Iliac Colotomy, or Littre's Operation, consists in opening the lower portion of the colon or sigmoid flexure through the anterior abdominal wall. An incision 2 to 3 inches in length is made at right angles to a line extending from the anterior superior spine to the umbilicus, the centre of the incision corresponding to the junction of the outer and middle thirds (Fig. 319, C). The abdominal parietes are divided, and the peritoneum opened. Two fingers are then inserted, and the sigmoid flexure sought for ; it is recognised by the presence of the appendices epiploicae and the longitudinal bands of muscle fibres. It is carefully examined, and the upper part of it selected for fixation in the wound, so as to diminish the risk of subsequent prolapse. It is desirable to withdraw a coil about 4 or 6 inches in length, together with its mesentery. Many different plans of fixing it are in vogue, but the method we prefer is to pass a strong silk thread through the parietes and parietal peritoneum on either side of the wound, the stitch traversing the mesentery en route. It is then made to traverse the same structures once more in exactly the same way, ABDOMINAL SURGERY 943 but at a distance of about half an inch from the former (see Fig. 347). The loose ends are then tied together, so as to bring the parietal peritoneum and sigmoid meso-colon into close apposition. A few additional stitches should be inserted, uniting the skin to the longi- tudinal muscular bands at each end of the incision, so as to prevent any subsequent retraction of the exposed bowel or escape of small intestine. Some surgeons simply secure the parietal peritoneum to the gut by a row of carefully inserted sutures ; others pass a glass rod through the mesentery and stitch the peritoneum to the skin, whilst it has also been suggested to make a hole through the mesentery and suture the two edges of the incision through it, i.e., beneath the bowel. The projecting portion of gut is then covered with purified protective, and an antiseptic dressing applied. At the end of two or three days the bowel is opened, no anaesthetic being generally necessary for this proceeding. About the eighth day a portion of the whole lumen of the gut should be Fig. 347.— Iliac Colotomy to show Fixation Stitch passing through Mesentery and Abdominal Parietes. removed, down to and even including the mesentery, so as to completely separate the upper from the lower end, and thus establish an efficient spur. The deep stitch is removed about the twelfth day. Should it be necessary to open the bowel at the time of operation, the distended coil is first withdrawn and the deep trans-mesenteric stitch passed and tied. The margins of the wound are then carefully protected by antiseptic compresses, and the bowel is tapped with a trocar and cannula. When the first gush of flatus and faeces has escaped, the opening is enlarged and a large-sized Paul's tube tied in. The skin is then carefully sutured all round to the bowel and mesentery, and a collar-like pad of gauze protects the junction. When cicatrization of the wound is complete, a protective apparatus is required in order to keep the patient clean. This should consist of a hollow oval cup, made of plated metal, vulcanite or celluloid, with a rolled edge, and kept in position either by a truss spring or an abdominal belt. This hollow cup should be large enough to include a 2-inch margin of skin all round the opening, and in the concavity a small portion of antiseptic dressing 944 A MANUAL OF SURGERY is placed. Such an apparatus enables the patient to go about in comparative comfort ; the bowels are encouraged to act thoroughly every morning by means of an enema, so that no further disturb- ance need occur during the day. Comparison of the Two Operations. — As we have already stated, the iliac operation has almost entirely superseded the lumbar pro- ceeding, and the reasons for this change of attitude are as follows : (i) The operator is not hampered by lack of space, as so frequently happens in opening the loin. (2) A clean incision can be made without tearing or bruising the subperitoneal fat. (3) The sigmoid flexure is readily identified, and no other viscus is likely to be opened for it by mistake ; if the colon takes an abnormal course in the loin, or is provided with a complete meso- colon, the peritoneum has usually, if not always, to be opened, and thus the one advantage which can be claimed for the lumbar proceeding is lost. (4) An artificial anus situated in the iliac region can be attended to by the patient himself without assist- ance, and is more easily cleansed and protected. (5) It is occa- sionally possible for a certain amount of sphincteric control to be developed after the abdominal operation, owing to the muscles of the abdominal parietes becoming adherent to the coats of the gut. Of course, this can only be attained when these structures are brought into accurate apposition, as by the fixation stitch described above. (6) A more complete diversion of the faeces can be effected by the iliac operation than by the lumbar. In the latter it is impracticable to withdraw the whole lumen of the gut unless the peritoneum is opened ; an opening is merely made on one side, and one has to trust to the formation of a valve or spur of mucous membrane for the blocking of the lower aperture ; in the former the two segments of the bowel can be entirely separated. The objections urged against the iliac operation consist in the following facts: (1) That it involves the opening of the peri- toneum ; (2) that immediate relief to obstruction is more risky than in the lumbar method ; and (3) that there is a somewhat greater tendency to prolapse. The first of these objections must now be entirely waived. The second is certainly valid, but by a careful use of Paul's tube and by fixing the gut firmly to the skin by additional sutures the danger is minimized. Certainly the lumbar operation is not devoid of risk when an immediate opening of the gut is required. Lastly, if the surgeon is careful to see that no slack portion of gut exists above that which he fixes in the wound, i.e., if he opens the lower end of the descending colon, there will be but little likelihood of any subsequent pro- trusion. ABDOMINAL SURGERY 945 Appendicitis (Syn. : Perityphlitis, Epityphlitis, etc.). Appendicitis is an affection which may appear at any time of life, but is most common in the young. The male sex is more frequently attacked than the female in the proportion of 4 to 1 . The disease is of a most protean type, being sometimes of but slight significance, but occasionally running such a virulent course as to destroy life in a few hours. Its importance necessarily lies in the fact that the peritoneal envelope is always involved, and hence a certain degree of peritonitis is almost necessarily a con- sequence. ^Etiology. — Many different conditions contribute either directly or indirectly in determining an attack of appendicitis. (1) The appendix is to be looked on, not as an actively functional structure, but as a degenerated relic or remnant, which is apparently of little value or importance. Hence, as in other similar structures, it often has but a poor blood-supply, derived from the posterior ileo-caecal branch of the ileo-colic artery. The main nutrient vessels traverse in the meso-appendix, but a second twig often runs down the base of the mesentery, and is more or less independent of the others. In the female it is said to have an additional twig from the right ovarian trunk, and this may explain why the disease is less common in females than in males. (2) A large amount of lymphoid tissue is present in its walls, so much, in fact, that the title of ' abdominal tonsil ' has been applied to it. Inflammatory processes are thus readily set up within its walls as a result of the absorption of toxins or organisms, which are almost constantly present within it. (3) Its length and direction vary considerably in different individuals. In length it may measure anything between 1^ and 11 or 12 inches, but is usually 3 to 4 inches long, whilst, as to direction, it may lie in any axis ; perhaps most fre- quently it is to be found behind the caecum, and pointing down towards the pelvis. The facility with which the intestinal con- tents find their way into its lumen thus varies in different indi- viduals, and it seems probable that appendicitis is more commonly met with where it is so placed as to readily admit material which is with difficulty expelled, i.e., when it is transverse or directed downwards. A long appendix is also more liable to become twisted on itself. (4) The extent to which the meso-appendix is attached is also an important element, since the portion which projects beyond its free border is less well supplied with blood. As a matter of fact the mesentery rarely extends beyond the junc- tion of the middle with the distal third, and perforation often occurs about this spot. (5) The communication with the caecum is usually a small one, and is guarded by an insignificant fold of mucous membrane, known as the valve of Gerlach. Sometimes this aperture becomes blocked, or the orifice stenosed, so that an 60 946 A MANUAL OF SURGERY accumulation of mucus occurs within the appendix. (6) Faecal concretions or foreign bodies, such as pips, pins, etc., are also met with within it, and by their presence and irritation may determine an attack of inflammation. Foreign bodies are much less common than was formerly imagined (present in less than 4 per cent, of cases), occurring most frequently in children and young people. Faecal concretions (present in 15 to 20 per cent, of cases) are oval bodies, rarely more than half an inch in length ; on section they are found to be laminated, and consist of dried faecal material mixed with myriads of bacteria. They are not very hard, and can easily be cut with a knife. They are usually the result of chronic constipation, which is always to be looked on as a predisposing cause of appendicitis. Other causes of appendicitis are occasionally described, such as rheumatism, and in chronic cases tubercle or actinomycosis ; typhoid ulceration is rarely met with in the appendix. Dysentery is sometimes associated with appendicitis, though more commonly it leads to a true ulcerative typhlitis, involving the caecum. Injury in the shape of a strain or sudden twist is not unfre- quently mentioned as the cause of an outbreak, and probably acts by displacing a long appendix in such a way as to lead to its kinking and possibly to obstruction of the nutrient vessels. Whatever the assigned cause may be, it must ever be kept in mind that appendicitis is an infective malady, due to invasion of the walls of the appendix by organisms, especially by the Bac. coli, though ordinary pyogenic cocci, especially the Streptococcus pyo- genes, are often present in addition. Pathological Anatomy. — Bacteria find an entrance into the wall of the appendix either through an eroded area of the mucous membrane due to the impaction of a foreign body or of a faecal concretion, or else they are absorbed into the lymphoid tissue so abundantly present, and at once commence to develop and multiply. As a result of this the mucosa becomes greatly swollen and thickened, and as it is surrounded by fairly strong muscular walls, constriction of the vessels follows, preventing recuperative processes from being undertaken, and hence the bacteria are enabled to continue their destructive work. In con- sequence, ulceration of the mucous lining supervenes, or inter- stitial suppuration in the wall. Sometimes the small terminal artery of the appendix becomes thrombosed, or undergoes an obliterative endarteritis, leading to sloughing of one or more portions of the walls, generally at the apex. The veins also are liable to become thrombosed, and bacteria may find their way into the thrombus, causing its disintegration, and if emboli are detached, pylephlebitis or portal-vein-pyaemia, with possibly hepatic abscess, may result. The most important changes, how- ever, are those occurring in the peritoneum, which is always inflamed, and, indeed, upon the condition of this structure depends ABDOMINAL SURGERY 947 to a large extent the prognosis of the case. It may merely be thickened by a deposit of lymph, giving rise to adhesions which bind it down to neighbouring parts, or a localized suppurative affection may ensue ; or, again, an acute diffuse and usually fatal peritonitis follows, either as a result of rupture of the appendix, or as an outcome of sloughing or perforation of its walls. The localized abscess is in reality intraperitoneal, but its ex- tension is limited by the formation of adhesions between neigh- bouring coils of gut. When an attack of appendicitis has passed off, some stenosis of the lumen of the tube is a common sequence, and as a result of this the terminal portion may become distended with retained secretion, and the patient may suffer from intermittent attacks of colicky pain due to the efforts of the ap- pendix to relieve itself ; it will also predispose the individual to recurrent inflammation. Hence, from a clinical standpoint, the following varieties of appendicitis may be recognised : 1. Simple or catarrhal appendicitis, associated with a plastic peritonitis. 2. Ulcerative or gangrenous appendicitis, accompanied by a localized intraperitoneal abscess. 3. Gangrenous or perforative appendicitis, resulting in an acute diffuse sero-purulent peritonitis. Such a condition is frequently fatal, and constituted one of the commonest causes of the so-called ' idiopathic peritonitis ' of the old days. 4. Relapsing appendicitis, in which attack follows attack, some- times with very little interval. Clinical History. — (i.) The mild variety of the disease, known as a simple catarrhal appendicitis, to which is added merely a localized plastic peritonitis, usually commences somewhat sud- denly, the patient being seized with pain in the right iliac fossa, and accompanied by nausea, vomiting, more or less complete constipation, and slight fever (101 or 102 F.). An examination of the abdomen reveals definite tenderness in the right iliac region, most marked at a spot corresponding to the base of the appendix, i.e., i£ inches inwards from the anterior superior iliac spine, along a line drawn towards the umbilicus (McBurney's spot), whilst the right leg is usually drawn up in order to relax the tension of the abdominal muscles. A swelling, generally dull on percussion, may sometimes be detected by palpation, a little below McBurney's spot, and consists of coils of intestine matted together over and around the inflamed appendix. Such symptoms usually last three or four days, and then, if properly treated, resolve satisfactorily without any abscess formation. This simple form of the disease is exceedingly common, and the prognosis is, on the whole, favourable. Tofft, of Copenhagen, found adhesions in the neighbourhood of the appendix in 35 per cent, of all bodies subjected to post-mortem examination. 60 — 2 948 A MANUAL OF SURGERY (ii.) The more serious variety, commonly resulting in a localized abscess, may commence in a similar way, but with more acute symptoms. There may be an initial rigor, and the temperature soon runs up, even to 104 F. Some general abdominal tender- ness and distension follow ; constipation is often absolute, and fa?cal vomiting may occur. The muscles on the right side of the abdominal walls are held tense and rigid, and a well-marked swelling can usually be detected in the iliac fossa. Under a careful regime this may disappear, and the symptoms gradually abate in their severity, the temperature and the pulse falling con- currently ; but it is very common for suppuration to ensue, and such is indicated by the temperature persisting at its original high level, or by the pulse-rate increasing in rapidity, whilst the temperature falls. Fluctuation is rarely to be detected in the early stages, and, indeed, it is bad practice to wait for it before interfering, since there is a considerable probability that the tension within the abscess may be sufficient to break down the wall of newly formed and not too strong adhesions, and the general peritoneal cavity may be thus infected. The abscess develops at first around the appendix, and is, of course, primarily intra- peritoneal. Not unfrequently it bursts into the bowel, and there- by relief is gained without the assistance of surgery ; some authorities, indeed, maintain that this occurs in every case of the more severe type which resolves. In other instances it may point externally, either through the anterior abdominal wall, which becomes congested and oedematous as the pus approaches the surface, or through the loin, the pus having invaded the retroperitoneal cellular tissue. In the latter case, it is sometimes found that the abscess burrows widely up and down the back of the abdomen, and may even extend behind and above the liver, constituting a subphrenic abscess. Not unfrequently it tracks up along the inner or outer side of the ascending colon, and then may get into relation with the under surface of the liver. In other patients, and especially when the tip of the appendix lies over the brim of the pelvis, the pus travels downwards and forms a collection behind the rectum ; the surgeon must never omit a rectal examination in appendicitis, where the temperature is of such a nature as to suggest the existence of an abscess, and yet no evidence of one can be found. Should it burst into the peri- toneal cavity, all the phenomena of perforative peritonitis super- vene, probably indicated by a sudden fall of temperature, and followed by increased abdominal pain and distension. A faecal fistula may follow the bursting or opening of any of these abscesses. In not a few cases the patient's general symptoms improve after the first outbreak ; the temperature may become normal, the pain decrease, and the vomiting cease. It is often difficult to be certain whether this improvement is merely temporary, or is ABDOMINAL SURGERY 949 the commencement of a true convalescence. Under the former circumstances i.e., if it is merely an interval of quiescence), careful examination will probably reveal some disturbing factor ; either the abdominal distension persists, or perhaps hiccough is present, or a well-marked, though localized, tenderness continues, perhaps only to be detected per rectum, or the pulse.rate may remain unduly high. After a few days- the temperature begins to rise once more, the focal symptoms become more urgent, and a subacute or chronic abscess forms. A complication likely to occur in the more severe types of the disease is pylephlebitis, or infective thrombosis of the branches of the portal vein in the liver. Such would be indicated by recurrent rigors, and possibly by pain and tenderness in the hepatic area. Necessarily it is almost invariably fatal. (iii.) Diffuse septic peritonitis results either from the rupture of a localized intraperitoneal abscess, and will then be preceded by the symptoms outlined above, or is present from the outset, being then due to primary perforation or gangrene of the appendix itself. The ordinary signs of acute peritonitis are developed (see p. 895), but possibly there may be obtainable some history of pain starting in the right iliac fossa, which will give a clue to the diagnosis. (iv.) Relapsing appendicitis is characterized by recurrent attacks of varying gravity in an individual who has been once the subject of the disease. They may occur only at prolonged intervals, or be so frequent as to entirely incapacitate the patient, and are mainly due to the presence of some abnormal adhesion or con- striction of the appendix. It is not uncommon for the appendix to become fixed to the sheath of the psoas muscle, and then any excessive movements of the limb may light up an attack. Where stenosis exists, secretions containing bacteria may be pent up behind the constriction, and from time to time the patient suffers from severe pain of a colicky nature without fever, supposed to be due to an attempt to get rid of the excess of mucus. Such attacks have been named ' appendicular colic' In a few cases the ap- pendix becomes totally obliterated after a time and incorporated in a mass of adhesions, a natural cure being thus established ; but more frequently, if these recurrences are allowed to continue, the patient finally succumbs from diffuse peritonitis. The Diagnosis of appendicitis ought not to be a matter of great difficulty if the practitioner bears in mind the cardinal symptoms, viz., pain and tenderness in the right iliac fossa, together with fever, vomiting, and constipation. If to these are superadded the existence of a localized swelling beneath the tense and rigid abdominal muscles, but little doubt can remain as to the nature of the case. The Prognosis, on the other hand, is never absolutely certain, for, as has been well pointed out by many acute observers, the 95 o A MANUAL OF SURGERY initial symptoms are frequently alike in all the varieties, and hence one can never know what course the case is going to take ; as R. Morris, of New York, says, ' The infected appendix is a cap which sometimes snaps, sometimes flashes, and sometimes causes an explosion, and none of us can tell in advance just what is going to happen.' As particularly bad signs may be mentioned a con- tinued high temperature, in spite of rest and careful dietetic measures, or a fall of temperature with increased rate of the pulse. Persistent hiccough is also a bad sign. The existence of a swelling in the iliac fossa is not a bad sign, but rather the reverse. Absence of a localized swelling is due either to a defective formation of protective adhesions, and hence is likely to be noted in the most acute cases, or to the appendix being placed behind the caecum in a position less favourable to operative measures. Treatment. — So much has been written on this subject during the last ten years, that it is extremely difficult to compress even a brief summary of the many facts observed into a necessarily limited space. Formerly typhlitis was the exclusive property of the physician ; but the last decade has brought about a great change, and many authorities consider that appendicitis is more justly within the realm of the surgeon, or, at any rate, that a surgeon should always share the responsibility of treatment with the physician. At any moment complications may develop even in what appear to be simple cases, in which surgical assistance will alone hold out any hopes of saving the patient. In America surgery is the recognised treatment for almost every case of the disease ; in this country more conservative ideas still persist, but we are glad to note that a more healthy opinion is gradually gaining ground, and that surgical interference is becoming recognised as the most appropriate means of treatment in many cases. In the milder form of appendicitis, where the temperature does not run above ioi° and the symptoms are not severe, all that is required in the majority of instances is to put the patient to bed, and apply fomentations locally ; the lower bowel should be emptied by an enema, and if it seems likely that there is an accumulation of irritating fasces within the intestine, a dose of castor-oil or of calomel may be administered. A fluid, unstimulating diet is all that is permitted, and should there be much vomiting, rectal alimentation may be resorted to. Possibly a little morphia may be given with advantage to quiet the patient and check peristalsis; but the less the better, since it tends to mask symptoms. In the graver cases the same general treatment may be insti- tuted to start with, but the question as to the advisability of operation will soon have to be faced. There are certain conditions in which all surgeons are agreed as to operation being essential, viz., where general peritonitis is present, or when an abscess is pointing. ABDOMINAL SURGERY 951 In the former case the only hope that exists, and even that is of the slenderest description, lies in opening the abdomen (usually in the middle line), flushing it out with some weak antiseptic lotion, or perhaps better with sterilized salt solution at a temperature of about 108° F., and searching for the appendix. If found, it should be removed, and drainage, either by Keith's tubes or by gauze wicks, must be arranged for. In the great majority of cases death will ensue in spite of all our precautions, but the more recent reports certainly show better results. When an abscess is evidently present, being indicated either by fluctuation or by a commencing oedema of the abdominal wall, there should be no hesitation in cutting down. An incision is made over the cedematous spot, and deepened carefully, since the tissues are probably matted together, and cut like bacon or brawn. The knife or index-finger will suddenly sink into the abscess cavity, and a gush of fcetid pus follows. The cavity is gently explored, so as to ascertain whether or not the appendix can be felt ; no undue force should be used, for fear of breaking down adhesions and thus opening the general peritoneal sac. If the appendix cannot be readily found, it is best left alone ; the abscess is thoroughly irrigated, drainage is provided for, and the incision partly closed. Probably the case will go on well, the discharge losing its smell about the third day, and the remaining sinus will gradually heal by granulation. Should the appendix, however, present itself, it should be removed. It is, however, in those cases where neither of the above condi- tions are manifest, and yet the symptoms, both local and general, point to the fact that a lesion of considerable gravity is present, that the greatest difference of opinion exists. We are quite ready to admit that in many instances conservative or medical treat- ment will suffice to bring about a satisfactory result ; but this can never be depended on, and, unfortunately, only too many lives have been sacrificed through an unwillingness to call in a surgeon, except at the last moment. Under these circumstances, even if acute peritonitis has not occurred, the patient is profoundly toxsemic or exhausted by preceding suffering ; hence any operative measures are likely to fail through the asthenic condition of the individual, even if the local phenomena are such as can be efficiently dealt with. Personally, w^e are distinctly in favour of early operation, and the general rule (to which, of course, there are exceptions) which we should suggest as justifiable, is that, if in spite of suitable rest and medical treatment the symptoms, both general and local, are not commencing to abate at the end of forty-eight hours, operation should be undertaken. The great advantages we would claim for this pro- cedure are : (1) That the patient is not in a state of collapse from toxaemia, and hence can stand the shock of an intraperitoneal exploration without much risk ; (2) that the appendix itself is not so likely to be tied down by a mass of firm adhesions, and can 952 A MANUAL OF SURGERY thus be found, isolated, and removed ; (3) that such removal is most desirable in order to secure the patient against the danger of recurrence ; and (4) that a much smaller incision will be needed under these circumstances, and therefore there is less chance of a ventral hernia subsequently forming. The following conditions may also be mentioned as specially indicating operation : per- sistent distension of the abdomen, hiccough, or a continued high pulse-rate in spite of a falling temperature. Operation. — Probably the best incision is an oblique one, crossing McBurney's spot, or a little below it, and parallel with the outer end of Poupart's ligament, somewhat similar to that for ligaturing the external iliac artery (Fig. 319, D). The whole thickness of the abdominal wall is freely divided, and the peritoneum, if need be, opened, so as to expose the caecum. The appendix is then carefully sought for, after protecting the general cavity by sponges ; it may be necessary to lift the caecum from its bed in order to find it, or to separate agglutinated coils of intestine. In cases of diffi- culty, the longitudinal bands of muscle on the ascending colon should be traced downwards to the appendix, where the three sets of fibres converge. An abscess usually containing extremely offensive pus may be opened in this way ; but if the operation is an early one, there is often no pus around the appendix, although its walls may be yellow from purulent infiltration. Whenever possible, the appendix should be removed ; it is first freed from adhesions, and the meso-appendix ligatured. If sufficiently healthy, a formal amputation, as in the chronic cases, should be undertaken, but such a procedure is often impracticable. A silk thread is then tied around the base about half an inch from the caecum, and the appendix cut off; the stump is, if practicable, buried by the insertion of two or three sutures into the serous membrane covering the caecum. Not unfrequently, however, the tissues are too much infiltrated and matted together to admit of such proceedings ; all that can be done is to stuff the wound with long strips of gauze, and allow it to heal by granulation. In the earlier more favourable cases, where actual suppuration has not occurred, the cavity is washed out after removal of the appendix, a drainage-tube inserted, and the abdominal wall partly closed. After the operation the patient should be fed mainly per rectum for a few days, stomach-feeding being gradually commenced about the third day. A small amount of opium may be needed, and, if all is going well, the bowels may be opened by the use of enemata in about five days if they have not already acted. For relapsing appendicitis, radical treatment must be instituted if the attacks are at all frequent, and possibly it would be justifiable to lay down the rule that operation should be undertaken in the quiescent period after the second attack. If left till many attacks have occurred, the task may prove very difficult, owing to the number and density of the adhesions which are then present. ABDOMINAL SURGERY 953 They are dealt with in the best way practicable, and the appendix thus freed is amputated. This is accomplished by dividing the serous coat by a circular incision, and retracting a cuff of serous and muscular tissues sufficiently to enable the mucous membrane to be ligatured, divided, and then covered over and buried by stitching or ligaturing the cuff of serous membrane over the end. A plan of dividing the abdominal wall suggested by McBurney may be employed in cases which promise to be of a simple nature and not complicated by many adhesions. The incision is as above ; each of the three flat muscles is divided in the course of its fibres, and held aside by retractors. The peritoneum is divided trans- versely. After the appendix has been removed, each layer is sutured separately. This method minimizes the risk of hernia, but it is not suited to cases where many adhesions are likely to be present, since an enlargement of the incision downwards, such as is almost necessarily required, involves a crucial division of one or more of the muscles. Sequelae. — A Facal Fistula may result from a perforative ap- pendicitis when the abscess has been merely opened, and no radical treatment undertaken at the same time, or it may follow an amputation of the appendix from sloughing or yielding of the stump. It is usually small in size, and sinuous in its course, and may in many cases close of itself. Occasionally it is necessary to deal with it by laying bare the caecum in the iliac fossa, and re- moving the appendix or suturing the opening. Failing that, it may be necessary to short-circuit the caecum. A Ventral Hernia sometimes follows from the yielding of the cicatrix in the abdominal wall after an abscess has been opened and drained. Both omentum and bowel, perhaps matted together and adherent to the cicatrix, are found in the protrusion. In some cases it may suffice to cover it with the concave pad of a truss, but in others operation is required ; adhesions must be divided or broken down, and often the opportunity can be taken of removing the appendix, if this has not already been accom- plished. The margins of the divided muscles are then sought for, and united by a row of buried sutures in the ordinary way. Affections of the Liver. Rupture of the Liver is produced by injuries to the abdominal walls, such as blows, kicks, or crutches, or it may be torn by the broken end of a rib. Penetrating injuries also occur, as from sword or dagger thrusts, and the organ may be involved in a gun- shot wound. The resulting lesion varies considerably ; the gland may be merely torn or contused from a non -penetrating blow, or freely incised by a sharp cutting implement, in which case some of the larger venous trunks are likely to be divided ; a bullet some- times produces almost total disorganization. The amount of 954 A MANUAL OF SURGERY injury depends, to some extent, on the condition of the organ ; if it is firm and sclerosed, it may receive little damage from a blow which would otherwise do it considerable harm, whilst if it is enlarged and fatty, it is readily torn. The chief Symptoms are shock, which is often not very exces- sive, pain and tenderness in the right hypochondrium, and the evidences of loss of blood. The last is, perhaps, the most im- portant, as upon its severity depends to a large extent the result. Sometimes the capsule remains intact, and then, although there is considerable intraglandular ecchymosis and laceration, no free blood escapes into the peritoneal cavity. Such a lesion is not unlikely to be followed by an abscess of the liver. When the capsule is torn, intraperitoneal haemorrhage is sure to ensue ; if slight, the patient, though suffering from all the phenomena characteristic of loss of blood, may recover, the blood being absorbed, and the wound in the liver cicatrizing. This process is usually attended by a certain amount of jaundice and some vomiting, whilst the urine is also tinged with bile pigment. In other cases, the blood collects at first in the upper part of the abdomen, but gradually extends downwards ; if the bowel is uninjured, recovery may ensue, but not uncommonly there is some associated contusion of the gut wall, through which intestinal bacteria find their way, giving rise to a localized or general peritonitis. Of course, in the more severe lesions where perhaps the left lobe is entirely torn off or a portion hopelessly contused, death from haemorrhage is almost certain to ensue in a very short time. The Diagnosis of hepatic rupture turns mainly on the history of the accident, the situation of the blow, and the resulting symptoms. Evidences of intraperitoneal bleeding, associated with pain in the right side, are extremely suggestive. It must not, however, be forgotten that the passage of a hansom cab or other vehicle over the body may give rise to much shock, and to considerable local pain and tenderness, and yet no serious mischief need have happened to the liver. The Treatment in the more simple cases consists merely in careful expectancy, the surgeon holding himself in readiness to interfere should any untoward symptoms supervene. The patient is kept quietly in bed ; ice may, if necessary, be applied to the side, the diet is limited to fluids, and the bowels emptied by enemata. In the more serious cases, where the diagnosis of ruptured liver is tolerably certain, an exploratory laparotomy should be undertaken, and an attempt made to deal with the wound. Possibly a median incision is as good as any, since the left half of the liver often bears the brunt of the injury. Out- lying ragged portions of the gland may be totally removed, prefer- ably by the cautery, though one usually has to depend upon plugging the wound with gauze in order to effect haemostasis. Clean linear cuts may be sutured with silk, but there is con- ABDOMINAL SURGERY 955 siderable difficulty in preventing the stitches from tearing out of the friable hepatic tissue ; it is wise to insert all the stitches first, taking up a good margin of the gland substance before attempting to tie any. The wound is then carefully closed by the fingers, and the sutures slowly and gently tightened. Very shallow wounds which it is impossible to stitch or plug satisfactorily may be seared with the cautery so as to stop bleeding, and then a gauze- wick drain is placed over them, and brought out of the external wound. Abscess of the Liver is due to a variety of causes. 1 . Multiple A bscesses develop in cases of pyaemia, whether the emboli are carried by the hepatic artery or by the portal vein. In the former case, the condition arises as a complication of general pyaemia of systemic origin ; in the latter, the originating focus of mischief is located in the area of distribution of the portal vein — i.e., in the intestinal canal. Thus, pylephlebitis, as it is termed, is not uncommonly met with in appendicitis, and some- times in typhoid fever, whilst suppurating piles may also lead to it. 2. Suppurative Cholangitis is another cause of multiple abscess of the liver. It consists of an inflammatory affection of the biliary ducts and passages, and is due to the spread of organisms from the intestine, or occasionally from the gall-bladder after an operation. The biliary ducts in the liver become enormously dilated, and filled with a mixture of bile and pus which looks very like yellow ochre. It is accompanied by pain over the gland and the general phenomena of pyrexia, but rigors are not present. The patient is not usually jaundiced, but bile may be found in the urine. Treatment is of little avail, but if a diagnosis can be made, and the gall-bladder has not been already incised, it may relieve tension to open and drain it. 3. Hydatid cysts may suppurate, and require treatment as for an abscess of the liver. 4. The more important abscesses, from a surgical standpoint, are those which, from their size, demand operative treatment. They may result from traumatism in the way stated above, or may arise in connection with hydatid cysts, but more commonly are of the type known as tropical abscess: The latter usually occurs in individuals who have travelled in the tropics, and 75 per cent, of the cases are attributed to dysentery. The exact mode of causation has not yet been fully worked out, but it seems probable that they are primarily of embolic origin. They are most fre- quently situated at the back of the right lobe, but, of course, any part of the viscus may be involved. Though often single, the cavity is frequently loculated, indicating that several original foci of suppuration have united together. Any of the ordinary pyogenic organisms may be found within them, and not unfre- quently the Bac. coli is present. In a few cases the Amoeba coli, an 956 A MANUAL OF SURGERY organism which is found in the bowel in some forms of dysentery, has been discovered. Occasionally the pus is sterile, the causative organisms having probably been disposed of, possibly as a result of the chronicity of the process. The abscess wall consists of disintegrating hepatic tissue in acute cases, but may have a fibro-cicatricial wall in the more chronic forms, and in an old- standing abscess the limiting membrane may be as tough as leather. The pus is sometimes of the ordinary type, but not uncommonly reddish-brown in colour, somewhat like chocolate, and of a most nauseating odour. The Symptoms are in some instances extremely slight, the patient perhaps dying of peritonitis due to its rupture without its presence having ever been suspected. The individual usually complains of a sense of weight and fulness in the right hypo- chondriurn, and in the more acute cases this may be accompanied by severe pain and localized tenderness over the whole hepatic region, the pain being also referred to the right shoulder. A certain amount of febrile disturbance occurs, the degree of which depends on the rapidity of formation of the abscess ; in the more acute forms the temperature is high and rigors may be present. The pyrexial phenomena are associated with loss of appetite, rapid and well-marked emaciation, and perhaps a certain amount of icterus, though the latter is not usually a prominent phenomenon. On physical examination a more or less evident enlargement of the liver will be detected, with, perhaps, a feeling of elasticity, or even of fluctuation at some spot. The dulness often extends up towards the thorax rather than downwards, though when the abscess is situated not far from the free margin of the liver, this is not the case. A doubtful diagnosis can sometimes be con- firmed by the aspirator or hypodermic needle, but this should not be utilized unless one is fully prepared for immediate opera- tion in the case of pus being found. Manson directs that the aspirator needle should be introduced in the following situations : (i) In the right axillary line through the seventh or eighth costal interspace ; (2) just below the ribs in the right nipple line ; (3) immediately below the lung in the line drawn downwards from the angle of the right scapula. Left to itself, several distinct courses are open for the abscess to follow : it may become adherent to the anterior abdominal wall and point in the epigastrium, its onward passage being indicated by congestion and oedema of the parietes ; it may open into the peritoneal cavity, or into one of the hollow viscera, such as the colon or duodenum ; or, again, it may travel upwards, burrowing through the diaphragm, and either bursting into the lung, its contents being expectorated, or into the pleural cavity, leading to an empyema. Occasionally it remains passive as a chronic encysted abscess, and then the walls become very thick. One of us recently opened an hepatic abscess which had been diagnosed by a hypo- ABDOMINAL SURGERY 957 dermic needle twelve years previously, and left alone. It con- tained about two pints of pus, and the walls were fully | inch thick. The patient came under observation because the swelling was becoming more prominent, as the result of increased intra- abdominal pressure, due to pregnancy. Treatment. — Aspiration, repeated once or twice, has been fre- quently employed, but is of little value, and not a few cases are on record in which septic peritonitis or pleurisy has followed the introduction of the needle from the front or side respectively. Experience proves that the usual law of treating suppuration ought to be strictly obeyed, viz., that the abscess should be opened and drained. If pointing in front and adherent to the parietes, there is no difficulty or danger in making an incision over the most prominent spot and laying the cavity open ; it is then well flushed out and a drainage-tube inserted. If on dividing the abdominal parietes it is found that the liver is not yet adherent, it is perhaps best to plug the wound with sterilized or antiseptic gauze so as to determine the formation of adhesions to such an extent as to cut off the general peritoneal cavity ; in a few days the abscess can then be opened with safety. If there is no great thickness of hepatic tissue between the surface and the pus, a knife may be employed for this purpose ; but if the abscess lies deeply, it has been suggested that the thermo-cautery should be employed so as to prevent bleeding by sealing the mouths of the hepatic veins. When it is urgently necessary to open the abscess at once, even though no adhesions are present, the general serous cavity must be carefully protected by sponges or pledgets of gauze before letting out the pus, and the assistant must keep the parietes in close contact with the hepatic tissue. It may be possible to insert a few stitches through the liver substance, securing it thus to the parietal peritoneum ; otherwise one must trust to a careful packing of the wound. After opening the abscess, it is usually advisable to wash it out, and this may with advantage be repeated subsequently. When the abscess is in its most common situation, viz., the back of the right lobe, it is often most satisfactory to open it from the side ; a similar proceeding is sometimes needed when an abscess has been opened from the front, and does not drain properly. An incision is made a little behind the mid-axillary line through the ninth or tenth intercostal space, and a portion of one of the adjacent ribs removed. The pleural cavity is opened, and the costal pleura stitched carefully to that portion which covers the diaphragm ; it will be found that this structure lies nearly vertical in this position, and but little difficulty is experienced in shutting off the general pleural cavity. The diaphragm is then divided, and not unfrequently the peritoneal cavity is opened ; if so, it may be stuffed temporarily, so as to determine adhesions, and then the liver incised ; less commonly 958 A MANUAL OF SURGERY adhesions may have already formed, or a bare area of the liver may he found, through which the pus can be withdrawn and the abscess opened. Hydatid Cysts occur in the liver more frequently than in any other part of the body. For general details as to the life-history of the Tania ccliinococcus and the structure of hydatid cysts, see p. 187. They produce a localized painless enlargement of the liver, the cysts varying in size from a small marble to a child's head ; the outline is well defined if superficial, but not so if placed deeply ; the cavity is usually filled with fluid and daughter-cells. Fluctuation may be distinguished, and a hydatid fremitus or thrill (arising from the concussion of the contained daughter-cysts) may, it is said, be elicited on palpation. The diagnosis is easily made if the cyst projects from the lower border, but when deeply embedded in the organ it may be exceedingly difficult, and the tumour can only be distinguished with certainty from carcinoma or syphilis by the use of the aspirator, or preferably by an open exploration. The character of the fluid withdrawn from a hydatid cyst is at once conclusive, as it is of low specific gravity, viz., 1007 to 1009, slightly opalescent, with no albumen, and a trace of salt ; the presence of scolices or hooklets is the pathogno- monic feature. Terminations. — The cyst may remain latent and innocuous, or may actually dry up and form a mass somewhat like wet mortar, owing to the death of the organism ; or it may burst and be evacuated in different directions, with or without suppuration. Thus, it may open externally through the abdominal parietes, or into the peritoneal cavity, causing fatal shock and in many cases peritonitis ; or into the stomach or intestines, spontaneous cure usually resulting ; or it may penetrate the diaphragm, and the contents be expectorated, or set free in the pleural cavity, causing a rapidly fatal pleurisy. It has been known to open into the pericardium, or even into the hepatic veins, the contents then being impacted in the right auricle ; in both cases immediate death resulted. Treatment. — The ideal plan of dealing with a hydatid cyst would be to dissect it entirely away, and such is not altogether im- practicable in cases where the growth is superficial, since its con- nections with surrounding parts are not very intimate. The great danger to be dreaded is haemorrhage, and owing to the vascularity of the liver and the difficulty of controlling bleeding from it, this is an objection of the gravest importance. However, if the tumour is small and superficial, there need be no fear in attempting it, the cavity being firmly plugged with gauze for a few days. The surgeon, however, usually has to content himself with incision of the cyst, turning out the scolices or daughter-cysts, and inserting a large drainage-tube. If adhesions to the anterior ABDOMINAL SURGERY 959 abdominal wall are present, this can be accomplished at one sitting ; but if, as more commonly happens, none have been developed, it is wiser to undertake the operation in two stages, as for hepatic abscess, so as to make certain that the general peri- toneal cavity is firmly shut off. Another advantage which follows the division of the operation into two parts is that the latter pro- ceeding, viz., the incision of the liver and cyst, can be undertaken without an anaesthetic, and the patient is enabled to help in the removal of the cysts by coughing when required. Formerly aspiration and electrolysis were largely employed in the treatment of this affection. It has been found, however, that although a considerable percentage of cases could be cured in this way (more than a half), yet that it was not unaccompanied by risk of peritonitis, and that recurrence was often observed. Moreover, some of the fluid not unfrequently leaked into the peritoneal cavity, and probably from the absorption of some toxic product present led to urticaria, and sometimes to even graver phenomena of poisoning. Electrolysis merely acts by producing a puncture of the cyst wall and consequent leakage. Both of these methods should be entirely discontinued. A suppurating hydatid cyst is dealt with according to the same rules of treatment as hold good for abscess of the liver. Tumours of the Liver are rarely primary. Secondary sarcoma and carcinoma are by no means uncommon, but of course nothing can be done for them. A few cases are on record of removal of a tumour or gumma together with a portion of the tissue of the organ, but such must necessarily be a matter of such rarity that we cannot spare space to discuss it. Affections of the Gail-Bladder and Biliary Passages. Rupture of the Gail-Bladder results from such injuries as blows, crushes, kicks, etc., whilst it may also be produced by penetrating wounds or bullets ; occasionally it may follow ulceration from within, as from a large impacted gallstone. It is probable that in health the gall-bladder is occupied not by bile, but by mucus, and its function is apparently not to act as a bile reservoir, but as a pressure gauge regulating the flow of bile into the intestine. Whenever the biliary passages are stenosed or blocked, bile regurgitates, as also after death, and necessarily if the bladder is ruptured, bile will find it easier to escape in this direction than down the long and sinuous bile-ducts, and therefore extravasation into the peritoneal cavity always follows. Pure bile is sterile, but if any inflammation of the biliary passages has been present, organisms are sure to have found their way into the gall-bladder, and thus complications may readily ensue. If a considerable quantity of bile escapes suddenly into the peritoneal sac, acute peritonitis is certain to follow, whether organisms are present 9 6o A MANUAL OF SURGERY or not, owing to the irritating nature of the fluid ; jaundice is also developed from absorption of bile by the peritoneum, and it may also be found in the urine. A more gradual escape of the secretion will probably lead to the formation of a localized intra- peritoneal abscess or collection of fluid, associated with jaundice and probably clay-coloured stools. In a penetrating wound bile and blood will escape on the surface, and septic peritonitis is almost sure to follow. The immediate Symptoms are those of shock and severe hypochondriac pain, and this will be succeeded by either acute peritonitis or by the formation of a localized intraperitoneal swelling, together with jaundice. When the existence of such a lesion is suspected, Treatment always consists in an exploratory laparotomy. The fluid within the abdomen is carefully removed with swabs or washed away, and the gall-bladder carefully examined. Should only a small injury be found, it is perfectly feasible to close it by sutures ; a gauze wick should, however, be passed down to the lesion for a few days so as to provide a means of drainage should leakage occur. A more serious rupture will necessitate removal. of the gall-bladder, or else the margins of the wound may be stitched to the abdominal parietes, and a biliary fistula thus produced. Should the common bile-duct be entirely divided, the ends should be closed by sutures and a cholecysten- terostomy undertaken ; a small wound in the duct may be sutured. Cholelithiasis is the term applied to the presence in the gall-bladder of Gallstones. These consist mainly of crystals of cholesterine, held together by mucus and coloured by the bile pigment ; they are soluble in chloroform. When first passed and moist, their specific gravity is a little higher than that of water, and hence when immersed in it they sink ; after drying, however, they are found to float. The number present varies immensely ; sometimes a single large one exists, which is more or less barrel- shaped ; more frequently they are multiple, scores or hundreds being present, and are then usually faceted, and with a satin-like yellowish lustre. The Origin of gallstones is not yet fully understood, but there seems no doubt that they are primarily due to an inflammatory condition of the wall of the gall- bladder or biliary passages; they occur most commonly in women who have suffered long from dyspepsia and constipation, and may be associated with cancer, either as cause or effect. In a case dealt with by one of us, the origin of the trouble seems to have been the swallowing of a pin many years previously, which worked its way into the gall- bladder, set up an inflammation which resulted in the formation of calculi, and only appeared again after a successful operation, when sixty-six stones had been removed. The Symptoms produced are extremely variable. Their occur- ABDOMINAL SURGERY 961 rence is usually preceded by dyspeptic phenomena, which have perhaps lasted for years, and by constipation. Some pain is com- plained of in the right hypochondrium, but possibly nothing very serious is noted, until a physical examination reveals the distended gall-bladder, which forms a tumour projecting from under cover of the ribs, usually the 8th or 9th, and tending to enlarge down- wards towards the umbilicus ; it is usually firm, elastic, and perhaps fluctuating ; it moves with the liver during respiration, and there is never intestine in front of it. Such a condition often yields to medical treatment ; the diet has to be carefully regulated, and a sufficient amount of exercise ordered. Alkaline purgative medicines are usually employed, and a well-to-do patient may be sent to Carlsbad to drink the waters. Possibly massage may be utilised to assist in the extrusion of the calculi, and drinking con- siderable quantities of olive-oil is said to be beneficial in effecting the same object. There are several complications, however, which may call for surgical treatment. 1. Inflammatory phenomena connected with the gall-bladder (cholecystitis) may assume considerable proportions. Acute in- flammation is usually due 'to infection with the Bac. coli, which travels up the biliary passages from the intestine. It is evidenced by acute pain and tenderness in the right hypochondrium, together with vomiting, constipation, and fever. The constipation may be of such a marked character as almost to amount to obstruction, and arises mainly from paralysis of the neighbouring coils of gut, e.g., the duodenum and transverse colon. Suppuration may follow, the abscess either bursting externally or into the peritoneal cavity, or possibly into one of the hollow viscera. In other cases the inflammation subsides after a time, but results in a consider- able development of adhesions Avhich interfere with operative proceedings, and may also determine an attack of intestinal obstruction. Should the inflammatory mischief extend up the hepatic duct into the liver substance, diffuse suppurative cholangitis will result, and may lead to a fatal issue. A condition of chronic peritonitis is likely to follow whenever calculi remain lodged in the gall-bladder for some time. 2. Biliary colic is another most distressing complication, due to the onward passage of gallstones along the ducts. The pain is of a most acute character, doubling the patient up, and causing considerable shock ; it radiates from the right side, shooting over the scapular region and into the back ; it commences abruptly, and continues in paroxysms accompanied by vomiting until the stone is either discharged into the intestine or slips back into the gall-bladder, leading to a sudden cessation of the pain ; a sense of tenderness and discomfort may, however, persist for some time, and possibly a little jaundice, owing to the swelling of the mucous membrane obstructing the passage of bile. These attacks some- 61 962 A MANUAL OF SURGERY times come on at more or less regular intervals, and may be so frequent as to produce great exhaustion. At the time, they should be treated by the application of fomentations to the side, and the administration of opium ; sometimes a large dose of olive-oil by the mouth may assist in the passage of the stone. If they recur at all frequently, cholecystotomy must be undertaken. 3. A gallstone does not always escape into the bowel ; it may become impacted, and then gives rise to a train of tolerably charac- teristic symptoms, which vary somewhat with the site of obstruc- tion. If the cystic duct is blocked, there is severe pain in the side, and perhaps distension of the gall-bladder with mucus, con- stituting a tumour which can be felt, but there is no jaundice. If the calculus is lodged at the junction of the common and hepatic ducts, there will be intense icterus, but the gall-bladder is not necessarily distended ; the liver, however, is likely to be enlarged from engorgement with bile. When the stone is impacted in the common bile-duct, the jaundice is intense, but the gall-bladder is usually small. Sometimes the stone lodges close to the intestinal end of the duct in what is known as the ampulla of Vater ; it may then ulcerate through into the bowel without much difficulty. If impacted higher up, it may work through into the duodenum or colon by a process of ulceration, or may escape into the retro- peritoneal cellular tissue, leading to an abscess ; or, again, it may open the peritoneal cavity, and thus cause acute peritonitis. Operative Treatment of Cholelithiasis. — The conditions which may call for operation in the course of a case of gallstones are as follows : (a) For recurrent attacks of biliary colic, which cannot be prevented by medical treatment ; (b) for persistent jaundice ; (c) when the gall-bladder can be felt enlarged and tender ; and (d) for acute cholecystitis. Cholecystotomy consists in opening the gall-bladder for the removal of calculi, or for purposes of drainage. It is best per- formed through an incision which runs parallel to the costal margin on the right side, and about an inch and a half from it, extending upwards as far as the middle line (Fig. 319, B). The peritoneum is opened, and the gall-bladder sought for, any adhesions present being carefully divided ; it will sometimes happen that these are so abundant as to prevent the surgeon from continuing the operation, the risk of opening the bowel by mistake being too great. The liver is drawn up, and the intestines are pressed downwards out of the field of operation by means of sponges or cloths held in position by a broad re- tractor. The general peritoneal cavity is thus carefully guarded from infection. If the gall-bladder is much distended, it is ad- visable to tap it with a trocar and cannula, and withdraw the chief portion of its contents ; the opening is then enlarged suffi- ciently to allow of the introduction of a scoop, or even of the finger, and by this means the calculi are removed. The bile- ABDOMINAL SURGERY 963 ducts are carefully examined both by the finger passed inside as far as possible, and outside along their whole length, and by means of a long probe passed down the duct. If the interior is tolerably healthy, it may be advisable to suture up the wound in the bladder, the threads not being allowed, however, to en- croach on the mucous membrane. A gauze wick should be inserted down to the incision before stitching up the abdominal parietes, so as to provide for drainage should there be any leakage of bile. More usually temporary drainage of the biliary passages is desirable in order to relieve the liver, and then a full-sized drainage-tube without any lateral openings is introduced into the gall-bladder and stitched to its walls, whilst the margins of the wound in the gall-bladder are united to the parietal peritoneum and transversalis aponeurosis. A biliary fistula is thus produced which discharges for a time ; but as soon as the obstruction to the onward passage of bile into the gut is overcome, the fistula closes. Occasionally this does not occur, and then the discharge of bile continues, necessitating further treatment. If there is sufficient evidence of the existence of bile in the motions to indi- cate that the passages are clear, a plastic operation for the closure of the fistula may be undertaken ; but if complete and permanent obstruction to the passage of bile is suspected, an artificial com- munication with the intestine (cholecystenterostomy) should, if possible, be established. It is often very difficult to remove a stone impacted in the cystic duct. Possibly it may be extracted by a lithotomy scoop, or pushed on from within, or squeezed forwards or backwards by the finger and thumb from outs'de ; or, again, it has been broken up from within by means of a needle, or crushed from without by forceps, the blades of which are guarded by indiarubber, but these are bad methods to adopt. In difficult cases of this nature it is better to incise the duct and extract the stone, the incision being subsequently secured by Lembert's sutures, long-handled palate needles being employed for the purpose. Sometimes the calculus is lodged in the bile-duct behind the second piece of the duodenum ; it is then sometimes possible to push the gut aside and get at the duct behind it, or in other cases it may be necessary to incise the duodenum longitudinally front and back, and after extracting the stone, to make a fistula between the duct and the posterior wall of the intestine. In other cases the stone is left alone, and in the course of a few days it may become dislodged by natural means, as evidenced by the passage of bile into the intestine. Cholecystenterostomy, or the formation of an artificial com- munication between the gall-bladder and the bowel, is required in cases where jaundice persists, owing to absolute stenosis of the common duct. It has also been undertaken for the relief of jaundice due to malignant disease, either of the head of the 61 — 2 964 A MANUAL OF SURGERY pancreas or of the intestine, causing pressure on the orifice of the bile-duct ; it is quite unjustifiable under these latter circumstances, as statistics have shown that the danger of such a proceeding is very great, seven out of eight of Murphy's cases dying. The parts are exposed as described above, the gall-bladder and duodenum are brought into contact, and a lateral anastomosis made by means of a Murphy button, or by simple suturing ; but Murphy's method is undoubtedly the better. Cholecystectomy, or removal of the gall-bladder, may be neces- sary for traumatic lesions, and for malignant disease, whilst it is sometimes employed after cholecystotomy in order to prevent any new formation of gallstones. The bladder has to be isolated, and may then be cut away, the divided end of the duct being secured by a double row of sutures. Affections of the Pancreas. The pancreas is an organ which rarely calls for the attention of surgeons, and only a few conditions need be mentioned. Wounds of the Pancreas occur, but are so often associated with damage to neighbouring important tissues that they seldom need treatment per se. Prolapse through an abdominal wound has been recorded in a few cases, the organ having been almost entirely separated from its connections ; however bruised or damaged, its total extirpation must never be resorted to, since diabetes is certain to follow ; it should therefore be carefully purified and replaced. Acute Purulent Pancreatitis is almost invariably a result of infection from the intestine, or from neighbouring parts. It produces symptoms of deep suppuration with excruciating pain, probably from implication of the cceliac plexus, and often causes death from purulent peritonitis. A pancreatic abscess may be opened from the front, but the greatest precautions must be taken against infecting the peritoneal cavity. The stomach is drawn up, and the surgeon burrows through the omentum between it and the transverse colon. A counter-opening for drainage can be made by the side of the first lumbar vertebra ; but it must be remembered that both the aorta and vena cava, and the root of the superior mesenteric vessels, lie behind the gland. Cysts of the Pancreas have been observed and treated in so many cases since 1887 that their characters are pretty clearly known. Simple com- plete obstruction to the duct has been proved exparimentally not to be a sufficient cause for the disease ; some pathological condition of the epithelium must also be present, preventing the re-absorption of the retained secretion. The fluid within is usually turbid and brownish from admixture with blood, odourless, and with a fairly high specific gravity ; it is of an alkaline or neutral reaction, and contains albumen, but no urea or bile ; it is capable of peptonizing albumen, of emulsifying fat, and of converting starch into sugar. The cyst can be felt as a rounded, tense, fluctuating or elastic swelling, placed deeply in the abdomen, immoveable, and perhaps transmitting the aortic pulsation. The stomach lies directly in front of it, as can be made evident by distending it with gas. It is usually a disease of middle life, occurring most frequently in men ; emaciation is not marked, although a good proportion of the fatty food passes away in the motions ; the skin is often dirty, earthy, and unhealthy- looking. Treatment consists in laying the cavity open, drawing off its contents, and draining it, the surgeon finding his way to the cyst between the stomach and transverse colon. A large tube is inserted, either through the front, or from the back by the side of the vertebrae. The skin around usually becomes irritated by the discharge, owing to a process of digestion. The prognosis ABDOMINAL SURGERY 965 with such treatment is very good, Treves having collected fifteen cures out of sixteen cases thus dealt with. Carcinoma of the Pancreas is met with either as a primary growth, or secondary to a similar disease of the pylorus. It is usually, but not invariably, of a scirrhous type, and may lead to distension of the stomach from pressure on and constriction of the pylorus, and to jaundice and ascites by involving the bile duct and portal vein. In one or two cases removal has been under- taken with success, although an exact diagnosis was not arrived at before the operation. Sarcomata and other tumours are very rare. Affections of the Spleen. Rupture of the Spleen occurs as a result of injury, causing great shock, pain in the left hypochondrium, and internal haemorrhage, usually to such an extent as to prove rapidly fatal. In less severe cases the blood collects in the left loin, and gravitates towards the pelvis, the right loin being often kept clear by the position of the mesentery. Laparotomy should be undertaken wherever practicable, and, if much damaged, the organ is removed, the splenic vessels being secured by ligature ; the results of such treatment have been most satis- factory. In a few cases it has been possible to stop the bleeding by inserting a gauze tampon, which is removed in a few days. Abscess of the Spleen may develop in the course of pyaemia, or follow an injury, especially if associated with a lesion of a neighbouring coil of intestine. The symptoms are merely those of deep suppuration in the left hypochondrium, and the abscess either finds its way externally, or bursts into the peritoneal cavity. It may be opened and drained with the same precautions as for any other intraperitoneal collection of matter, and the results hitherto obtained have been encouraging. In pyaemia the disease is often fatal before the local phenomena are recognised. Floating Spleen is occasionally congenital, but more commonly acquired, in consequence of tight lacing, injuries, or the presence of tumours. It is known by the existence of a moveable intra-abdominal swelling, whose shape is that of the spleen, and having a notch in its anterior border; its size increases after meals. It may be so displaced as to lie in the right iliac fossa, or even in the pelvis, and then has a long narrow pedicle which has, in a few cases, led to its torsion and strangulation. Splenectomy was formerly the only treatment, if the displaced organ caused discomfort or pain ; it has been found possible, however, to fix it, and several successful cases have now been recorded. Splenopexy, as the operation is termed, is best undertaken by pre- paring a bed for the organ outside the peritoneum in the loose cellular tissue beneath the floating ribs on the left side. The spleen is then slipped through a small hole specially made for the purpose in the parietal peritoneum, and secured by stitches, which pass through its capsule and anchor it to the under surface of the diaphragm. Tumours of the Spleen are met with either in the form of a general hyper- trophy, as in lymphadenoma or malaria, or as new growths, such as cysts (hydatid most frequently), or secondary carcinoma or sarcoma. The spleen also becomes enlarged in lardaceous disease, rickets, and many of the general fevers. An enlarged spleen constitutes a swelling which extends downwards from the left hypochondrium towards the umbilicus, the notch being felt anteriorly. The condition is recognised by the constant absence of intestine in front of it, by the resonant note obtained in the flank, by its mobility with respiration, and occasionally by its increased size after meals. The treatment, where advisable, consists either of splenectomy, or, in the case of cysts, of incision and drainage. Splenectomy, or extirpation of the spleen, has been undertaken for a variety of conditions, and its value and position, as a surgical procedure, are now pretty well established. For traumatic lesions it is both safe and justifiable. For primary hypertrophy, and for malarial enlargement, it may be performed 966 A MANUAL OF SURGERY if serious discomfort is being caused, and cannot otherwise be remedied. If drainage fails to cure cysts, excision may be performed. If malignant disease is diagnosed sufficiently early, the organ may be removed. Splenectomy for leucocythsemia is absolutely unjustifiable, all the cases operated on having died. The operation is performed through any suitable incision of sufficient length. The peritoneum having been opened, the organ is carefully examined, and if extensive adhesions are present, the surgeon will be wise to desist, since fatal haemorrhage is very likely to result from any attempt to break them down. If the organ is freely moveable, it is carefully drawn out of the abdomen, the pedicle being isolated, and secured temporarily by pressure forceps. It is then cut away, and the pedicle tied after transfixion with silk ligatures, the ends of which are cut short, and returned into the abdomen. General Remarks on Abdominal Operations. Before concluding this chapter, it seems desirable to add a few remarks dealing generally with the subject of abdominal opera- tions. Formerly they were of rare occurrence, and perhaps this was as well, since septic peritonitis frequently followed. At the present time no competent operator hesitates to open the abdomen whenever required, and the death-rate from preventible causes has been steadily diminishing. The peritoneum, which formerly the surgeon dreaded to touch, is now one of his best friends, if properly treated. Attention to minute details is essential if good results are to be obtained, and the following are a few points which may prove of service to those aspiring to success in this important branch of work. The patient should be carefully prepared, when circumstances permit, by regulating the diet and bowels for some days previously, so that the intestinal canal may be as free from organisms as possible ; a course of internal antiseptics, such as salol, calomel, /3-naphthol, may be advisable. If there seems a likelihood of streptococcal infection, the patient may be immunized to the action of such organisms by the previous injection for a day or two of a sufficient dose of antistreptococcic serum, as suggested by H. E. Durham; 10 c.c. given twice or thrice a day for two or three days will suffice for this purpose. No food should be allowed by mouth for some hours, and immediately before being placed on the table the bladder should be emptied. If the pro- ceedings are likely to be protracted, it is advisable to give a rectal injection of warm saline solution, or of beef-tea and brandy, half an hour beforehand, and possibly a hypodermic injection of strychnine (gr. ^). The patient should be warmly wrapped up and protected from cold, no unnecessary exposure being allowed. Chloroform is the best anaesthetic to employ in all abdominal cases, and the more complete the anaesthesia, the less the shock. Intraperitoneal operations are not painless, as has been often stated, for although the visceral peritoneum is not acutely sensitive, yet the parietal layer is, and any handling of this structure gives rise to pain and necessarily to increased shock, if the patient is conscious. ABDOMINAL SURGERY 967 The skin of the abdomen, the hands of the surgeon, and the instruments, are rendered aseptic in the usual way, special atten- tion being directed to the umbilical cicatrix. As soon, however, as the peritoneum has been opened, all strong antiseptics must be discarded, since they are likely to irritate this delicate membrane, thus doing more harm than good. Warm sterilized salt solution is the best fluid to employ for irrigating the serous cavity, or for washing out sponges, swabs, or cloths. If sponges are employed, they should be counted both before the operation, and again before closing the abdomen. Parietal Incision. — Formerly, whenever practicable, the incision was made in the middle line through the linea alba, in conse- quence of the facts that there is less bleeding in this situation, that all parts of the abdomen are easily accessible from it, and that the wound is more rapidly closed. It has been found, how- ever, that ventral hernia is a not uncommon sequela, and hence the general practice at the present time is to make one's incision in any suitable place, and preferably through vascular structures such as muscle, retaining the linea alba for cases where drainage of a septic focus has to be maintained. Even in such operations as ovariotomy, where the middle line gives the best access, it is wise to go through the rectus a little to one side of the centre rather than through the linea alba itself. The linea semilunaris, again, is a bad situation for an incision, since the traction of the muscles which are inserted into its outer side is so great that hernia is very likely to follow. On the other hand, care must be exercised not to place the incisions too near the bony margins of the abdominal cavity, or subsequent manipulations may be hampered by the rigidity of one side of the wound. The muscles should be cleanly divided, and it is wise to see that all bleeding is stopped before opening the peritoneum. Directors are best avoided, since they are very likely to wound the serous membrane, and are quite unnecessary in skilled hands. A small hole should be first made in the peritoneum, through which a blunt-nosed pair of forceps is inserted, and by lifting these up and allowing the blades to separate slightly, a convenient and safe substitute for a director is obtained. If a long incision is required, the left index and middle fingers are passed through this opening ; the intestines and omentum are thus kept out of the way, the peritoneum being well raised and divided by scissors to the required extent. The intestines must be most carefully guarded during the intraperitoneal portion of the operation, as if they are exposed to the air, the endothelial lining is quickly shed, and adhesions may form from without, whilst bacterial invasion may be predis- posed to from within. A series of cloths wrung out of warm sterilized salt solution must be kept wrapped round them by the assistant, and no unnecessary handling should be permitted. 968 A MANUAL OF SURGERY Closure of the Wound. — A careful toilette of the peritoneum must be undertaken before the abdomen is closed. All blood-clot is removed, sponges are counted, and, if there has been any extravasation of infective material, it is well to wash the site of operation with sterilized salt solution at a temperature of about io8° F., a proceeding which often assists considerably in mini- mizing shock. Many different methods of closing the parietal incision have been adopted, but perhaps the best consists in securing the serous and muscular coats by one set of deep inter- rupted stitches either of purified silk or of silkworm gut, which remain buried, and then in dealing with the skin by means of a continuous suture, which is subsequently removed. There is no advantage in taking up each of the layers separately, and the integrity of the abdominal cicatrix is increased by leaving all the deeper stitches in situ. Drainage is not usually called for in abdominal operations. If the surgeon is careful in his manipulations, and avoids measures which are likely to lead to subsequent oozing, the peritoneum may be closed with safety. Where an inflammatory focus has been opened, or when adhesions likely to bleed have been divided, or raw surfaces left such as occur after enucleating a parovarian cyst from the broad ligament, some means should be provided whereby any considerable effusion of fluid can escape. It is found that capillary drainage along a strip of gauze is the best that can be employed for blood or serum. Ordinary indiarubber tubes are liable to become blocked by portions of the intestine protruding into the lateral openings, whilst glass tubes, such as Keith's, are unyielding, and fail to accommodate themselves to the sinuosities of the regions needing drainage. Strips of aseptic gauze are therefore inserted like lampwicks, and along these, by capillary action, the effusion finds its way into the general dressing placed over the wound. Of course a certain amount of adhesive inflammation follows, and therefore the wick should be as small as possible, consistent with efficiency, and is changed or removed at the end of forty-eight hours. In some cases it is an advantage to enclose the gauze- wick in gutta percha tissue which has been* previously perforated here and there. Where, however, pus is to be removed, ordinary drainage-tubes must be employed. After-Treatment. — After the completion of the operation, the patient is replaced in bed, with the head low. If restless and irritable, a small dose of opium may be administered, but the less the better, since it induces intestinal paresis, and this in turn assists bacterial invasion from the gut. No food is allowed to enter the stomach for twenty-four hours, although the mouth may be washed out with warm water or with still lemonade, and nutrient enemata administered every four or six hours. The great essential is to avoid vomiting, and this is best accomplished by a complete temporary cessation of stomach-feeding. At the end of twenty- ABDOMINAL SURGERY 969 four hours, if all is going well, a little fluid nourishment may be given, and this is gradually increased. The bowels are left to nature, and unless constipation persists for some days no aperient is necessary. If peritonitis is threatening, the patient complains of abdominal pain and distension, whilst flatulence and vomiting are distressing symptoms (peritonism). Under these circumstances the adminis- tration of a saline purgative (e.g., 20 grains of sulphate of soda every half- hour) may stop the process by re-establishing peri- stalsis, removing bacteria and their products, and lessening the vascular tension. Failing this, the outlook is grave, though in some cases it may be justifiable to reopen the abdomen, wash out, and drain. CHAPTER XXXIII. HERNIA. By the term Hernia is meant the protrusion of some viscus from its normal situation through an opening in the walls of the cavity within which it is contained. This may affect not only the abdominal viscera, but also the brain and lungs, giving rise to conditions which we have already described. In this chapter we merely deal with hernia as met with in connection with the abdomen. The most common Situations at which hernia occurs are those spots where the parietes are weakened by the transmission of such structures as the spermatic cord and round ligament (inguinal hernia), or at the entrance of the crural canal, where the main vessels of the leg pass under Poupart's ligament (femoral hernia), or at the umbilicus (umbilical hernia). Viscera may, however, protrude through the obturator foramen, sciatic notch, the diaphragm, and in various other situations. ^Etiology. — A great many conditions may be associated, directly or indirectly, with the production of a hernia. They may, how- ever, be described for practical purposes under two main headings — the congenital and the acquired. Congenital Causes are rather predisposing than exciting in nature, and must be looked for amongst the many malformations and conditions of imperfect development to which the abdominal parietes and contents are liable. The following are the most important of these : (a) The non-obliteration of the funicular process of peritoneum, which in the male precedes and accom- panies the testicle on its progress downwards from the abdominal cavity to the scrotum, and in the female passes along the round ligament. The so-called congenital inguinal hernia results from this, although it must be remembered that the rupture does not necessarily show itself at birth, and, indeed, may not appear till after puberty, the term being therefore a misnomer. In females under the age of twenty-five, hernia into the canal of Nuck, as this peritoneal tube is called, is the most frequent variety met HERNIA 971 with, (b) The late descent of the testis, whether it finds its way into the scrotum or not, is usually associated with the formation of an inguinal hernia of the congenital type, or of some form of interstitial hernia. (c) Inherited weakness of the abdominal muscles and parietes, with unusual patency of the rings, will certainly predispose to this condition, and, moreover, there is no doubt as to the tendency of hernia to run in families. (d) Abnormal length of the mesentery or omentum has also been looked on as a causative factor ; but, although it may have some influence when other conditions are present, it can per se have but little effect, (e) Congenital phimosis, by inducing forcible acts of micturition, acts as an exciting cause. (/) Con- genital apertures occur in the linea alba or linea semilunaris, especially opposite one of the muscular intersections in the rectus, and through these one form of ventral hernia may develop. (g) The umbilicus is sometimes imperfectly developed at birth, permitting the viscera to protrude into the base of the umbilical cord (congenital umbilical hernia), (h) The diaphragm is also occasionally defective, allowing the stomach or other viscera to find their way into the thoracic cavity. Acquired Causes. — Hernia may result from any condition which tends either to weaken the abdominal parietes, or to increase the intra-abdominal pressure. Thus, all violent exercise, especially when of an intermittent nature and accompanied by excessive straining, as in lifting heavy weights, may determine its occur- rence, and the more so if the individual is forced to maintain the upright position, or wears tight bands or girths round the abdomen. Pregnancy stretches the abdominal walls, and parturition, by inducing violent muscular contraction, may originate a rupture, either through a split in the linea alba or through the crural canal. Prolonged and severe bronchitis also favours the occur- rence of a hernia by the increase of intra-abdominal pressure due to coughing, whilst the straining to pass water in cases of enlarged prostate or stricture may act in a similar manner. Chronic con- stipation is a frequent factor in its production, especially if the patient makes use of a closet with a high seat, whereby the inguinal canals are left unprotected ; in uncivilized races, where defaecation is performed in the squatting posture, the lower part of the abdomen is supported by the flexed thighs, and hernia is very uncommon. Patients with weak and bulging inguinal regions may with advantage use a low commode. In old and weakly people, an additional cause may be found in the slipping downwards of the mesenteric attachment, causing the intestines to occupy the lower part of the abdomen rather than the upper, so that the former bulges out over the pelvic brim. This is possibly due to weakening or relaxation of the unstriped mus- cular tissue which normally exists behind the peritoneum, passing from the posterior abdominal wall to the base of the mesentery ; 972 A MANUAL OF SURGERY it is sometimes called the muscle of Treitz. Obesity is also a pre- disposing factor to hernia, the accumulated fat being deposited in the omentum, mesentery, and subperitoneal tissue, thus increas- ing the intra-abdominal tension. Structure. — A hernia consists of a sac and its contents, the sac being formed of peritoneum, perhaps thickened by additional coverings, derived from the abdominal parietes, and the contents being the protruded viscera. The sac, or peritoneal investment of an acquired hernia, is in the early stages funnel-shaped, small, and thin, being derived from that portion of the serous membrane which normally lies over the hernial aperture. As the rupture increases in size, the sac becomes larger, partly as a result of the stretching of that portion of the serous membrane already protruded, and partly by the drawing down of fresh membrane from the neighbourhood ; in the groin this is derived rather from the iliac fossa than from the anterior abdominal wall. The sac is described as consisting of two portions — the neck and the fundus. The neck, sometimes large and open at first, gradually becomes narrowed, and is generally thickened from the irritation to which it has been ex- posed, either from the wearing of a truss or from the pressure of the contained viscera. The body, or fundus, varies much in size and shape, and may undergo considerable alterations in structure. (a) The sac, which is at first easily replaced, soon becomes irreducible from adhesions to surrounding parts, though it can still be readily emptied of its contents, (b) Inflammation may occur as a result of injury or pressure, constituting a form of localized peri- tonitis. If this is of a chronic type, the sac becomes thickened and opaque, with dilated vessels coursing over it, as seen especially in old irreducible umbilical hernia. Acute or subacute inflam- mation is also met with, resulting in the formation of adhesions between its inner wall and the contained viscera, or between the opposite sides of the sac if no other structures interpose. Natural cure of a hernia may in this way be occasionally produced by adhesions forming across the neck of the sac, or by an adherent plug of omentum, thus occluding the communication with the peritoneal cavity. The lower portion of the sac may in a similar way be shut off from the upper, either by a band of adhesions or by a septum of adherent omentum ; this isolated cavity is some- times the seat of a serous effusion, known as a hydrocele of a hernial sac. (c) Haemorrhage into the sac wall may result from violence, and will cause it to become much thickened, and even pigmented and leathery in appearance. The coverings of the sac are indurated in old-standing cases, and matted together in such a manner as to render it impossible to recognise the constituent parts. This is specially noticeable at the neck of the sac, where their union with surrounding structures is often such as to constitute an important predisposing element HERNIA 973 in the production of strangulation. The opening through which the hernia protrudes loses its characteristic features and shape, being enlarged, more or less circular, and displaced so that an oblique passage, such as the inguinal canal, becomes straight, the internal abdominal ring lying almost immediately behind the external. Contents. — Any viscus in the abdomen may be found in the sac of a hernia, except, perhaps, the pancreas ; as a rule, however, one finds only small intestine or omentum. An enterocele is the name given to a hernia containing some portion of the bowel. It is at first reducible ; but if the gut becomes adherent, either to the sac or to some other contained structure, it is rendered irreducible. It may also participate in an inflammatory condition of the sac ; whilst, if irreducible, obstruction may ensue from impaction of its contents, and if its vessels are constricted strangulation supervenes. For a descrip- tion of these conditions, see p. 945. The small intestine is much more frequently involved than the large gut. The amount of bowel protruded varies from a few inches to several feet. If omentum is found in a hernial sac, the condition is known as an epiplocele. As long as it remains reducible, it is likely to retain its normal texture ; but when large in amount, and especially if irreducible, it becomes ihickened, brawny, and matted together to such an extent as almost to constitute a solid tumour ; it is often the seat of an excessive deposit of fat, and in consequence of this overgrowth it may become irreducible, even when no adhesions are present. Serous cysts sometimes develop within it as a result of effusion between opposed surfaces. In some cases openings are found in it of sufficient size to allow the gut to pass through and become strangulated. When omentum and bowel are present in the same sac, the condition is known as an entero- epiplocele. Much discussion has been caused by the occasional presence of the ccecum in a hernial sac. It was formerly supposed that this viscus was only partially surrounded with peritoneum, and hence it was maintained that when found in a hernial sac the peritoneal investment was incomplete. It is now, however, universally acknowledged that a caecum has generally a complete serous covering and usually a mesentery, so that it is freely moveable ; consequently it may pass into a hernial sac in the same way as any other moveable part of the intestine, and several instances are on record in which it has been found in children to occupy the sac of an inguinal hernia on the left side. On the other hand, a few indisputable cases have been related in which the serous envelope was incomplete in a so-called ' caecocele.' The bladder may be associated with a hernial sac in two distinct ways, and usually in the inguinal region, (a) The fundus may be dragged downwards by the traction of the peritoneum, when 974 A MANUAL OF SURGERY the hernia has attained a colossal size. There is then only a partial peritoneal investment, the bladder lying outside the sac, and being adherent to it. Considerable irritability of tlK viscus is induced, and, owing to stagnation of urine in the displaced part, a phosphatic concretion may form therein, and such has even been removed by incision through the scrotum, (b) Occa- sionally a saccule of the outer wall of the bladder becomes ad- herent to the peritoneum, and is drawn down by it into the inguinal canal ; its presence may be suspected if a small hernia is associated with much vesical irritability. Such a protrusion consists merely of thickened mucous membrane and submucous tissue, and is devoid of muscular fibres ; it is very liable to be laid open if an operation for the radical cure is undertaken. If such an accident happens, the opening must be at once closed by sutures, which should not penetrate the mucous membrane, other- wise phosphatic concretions may form on the portion of suture exposed, and cause subsequent trouble. Loose foreign bodies, somewhat resembling marbles in size, are occasionally, but very rarely, met with in hernial sacs. They are derived from the detachment of one or more of the appendices epiploicse, which subsequently become enlarged from a deposit of fibrin induced by movement in the peritoneal cavity, and may even calcify. Signs and Symptoms. — -The characteristic features whereby a hernial protrusion is recognised consist in the presence of a rounded or pyriform swelling, in one of the normal or abnormal situations already mentioned, which increases in size when the patient stands, coughs, or strains, having, as it is termed, ' an impulse on coughing.' If intestine is present, it may be possible to obtain a tympanitic note on percussion, whilst the tumour is tense and rounded, and on pressure slips back into the abdomen with a distinct gurgle. An enterocele often gives rise to dyspeptic phenomena, and perhaps to colicky pains. An omental hernia feels soft and doughy, has a less distinct impulse, or even none, on coughing, and is replaced without a gurgle ; it is dull on per- cussion. When allowed to reappear, it does so slowly without any sudden impulse, the omentum insinuating itself gently down the inguinal canal, and gradually distending the sac. The Treatment of hernia, whether palliative by means of trusses, or radical by means of operation, differs so greatly in the various forms, that it will be better to discuss each one separately. Special Forms of Hernia. Inguii.al Hernia. — The term inguinal hernia is limited to those conditions in which a protrusion occurs into the inguinal canal, and, if allowed to progress, finally makes its way through the HERNIA 975 external abdominal ring. If it extends into the scrotum, it is termed complete, or scrotal ; whilst if it does not pass beyond the external abdominal ring, it is known as a bubonocele or incom- plete inguinal hernia. The neck is always in relation with the deep epigastric artery, and the structures of the cord are either spread out over the sac or are in close proximity to it. In the early stages, the pubic spine can be felt to the outer side of the neck of the sac ; but as it increases in size it lies over the spine, which can only be felt after pushing the hernia upwards and inwards. Two main varieties of inguinal hernia are described, viz., the oblique and the direct. An Oblique Inguinal Hernia (Fig. 348) is one which passes down Fig. 348. — Double Oblique In- guinal Hernia. Fig. 349. — Diagram of Acquired In- guinal Hernia, showing Serous Sac with Intestine coming down to the Top of the Testis. the whole length of the inguinal canal, entering at the internal and emerging at the external abdominal ring ; the deep epigastric artery is thus placed to the inner side of the neck. During its passage through the canal every form of oblique hernia pushes before it and becomes covered by structures representing the various layers of the abdominal parietes. Hence, in cutting down on such a sac, the surgeon will divide, in addition to the skin and subcutaneous tissues, (a) the intercolumnar fascia, derived from the transverse fibres of the external oblique which pass across the external abdominal ring ; (b) the cremasteric muscle and fascia, representing and extending from the internal oblique ; (c) the infundibuliform fascia derived from the fascia transversalis ; and (d) finally, a layer of subserous tissue varying in thickness, and closely surrounding the peritoneal sac. In practice, the surgeon does not attempt to recognise these different coverings, the oniy 976 A MANUAL OF SURGERY one of importance being the cremasteric, the muscular fibres of which are often evident, and serve as a useful landmark. There are three different forms of oblique inguinal hernia, viz., the acquired, the congenital, and the infantile or encysted. i. An Acquired Inguinal Hernia (Fig. 349) is one in which the sac consists entirely of peritoneum protruded from within the abdomen. It gradually increases in size, and finds its way along the cord to the scrotum. The sac usually extends as far as the head of the epididymis, but if of a large size it may overlap the testicle, which lies behind it. The structures of the cord are frequently spread out over the sac. In old-standing cases the internal ring is dragged downwards and inwards, and often lies behind the outer, and thus it may be difficult, apart from operation, to determine whether any particular hernia is direct or oblique. r ., r /'"^- Fig. 350. — Congenital Inguinal Hernia. A, Vaginal variety ; B, funicular type. 2. Congenital Inguinal Hernia (Fig. 350) is due to non-closure of the funicular process of peritoneum, which passes down to the scrotum with the testicle, and is usually obliterated completely except below, where it forms the tunica vaginalis. As already mentioned, the hernia does not necessarily appear in infancy, its occurrence being often delayed until puberty, or when the patient has to undertake heavy work. This form of hernia is much more frequently met with on the right side of the body, owing to the fact that the right testicle descends into the scrotum at a later date than the left. It is always characterized by becoming com- plete at once, and its development may be immediately followed by acute strangulation. In the majority of instances the patent funicular process is continuous with the tunica vaginalis, and the protruded viscera lie in contact with the testis, and somewhat obscure it ; this is known as a congenital vaginal hernia (Fig. 350, A). Less fre- quently the funicular process is patent only as far as the head of the epididymis, being shut off from the tunica vaginalis. The HERNIA 977 hernia under such circumstances exactly resembles the acquired variety, being unrecognisable from it except by the fact that it Fig. 351. — Infantile Inguinal Hernia. A., Prehernial condition with tunica vaginalis extending upwards to inguinal canal; B, hernial sac coining down behind tunica; C, sac invaginating the tunica vaginalis. becomes complete at once. It is termed a. congenital funicular hernia (Fig. 350, B). In every case of congenital hernia the structure* of the cord are spread out over the sac, and more intimately adherent to it than in the acquired form. Phimosis is usually associated with this condition in young boys. 3. The Infantile or Encysted Hernia is one occurring in individuals in whom the funicular process, although shut off from the ab- dominal cavity above, remains patent below, communicating with the tunica vaginalis, which cavity extends, in consequence, as high as the inguinal canal (Fig. 351, A). The hernia has a distinct sac, which passes down behind the open process, or invaginates it (Fig. 351, B and C). It can- not be recognised except on operation, when the surgeon is apt to open the tunica vaginalis, which, though reaching upwards, does not communicate with the general peritoneal cavity ; on removing or displacing this, the true sac of the hernia is found behind it. This is not so likely to occur at the present day, when the high incision is made. A Direct Inguinal Hernia (Fig. 352) is one which, though passing 62 Fig. 352. — Direct Inguinal Hernia. 978 A MANUAL OF SURGERY through the external abdominal ring, has only travelled through a portion of the inguinal canal ; it is never congenital, and usually smaller than the oblique type. The neck lies to the inner side of the epigastric artery, which is often arched very distinctly over it, passing also along its upper wall. The hernia traverses the space known as Hesselbach's triangle, which is bounded internally by the outer border of the rectus muscle, by the deep epigastric artery externally, and by Poupart's ligament below (Fig. 353). The obliterated hypogastric artery passes across this space in a Fig. 353. — Abdominal Wall from Within, to show Hernial Apertures. A, V, Femoral artery and vein ; S V, spermatic vessels ; P L, Poupart's liga ment ; V D, vas deferens; E, epigastric vessels; R, rectus abdominis; H, obliterated hypogastric artery ; i, internal abdominal ring; 2 and 3, sites of external and internal direct hernia in Hesselbach's triangle ; 4, crural ring for femoral hernia; 5, obturator foramen and vessels. direction parallel to its outer border, dividing it into two parts, and according to whether the hernia protrudes through the inner or outer segment, it is known as an internal or external direct hernia (Fig. 353, 3 and 2). The spermatic cord usually lies to the outer side of a direct hernia, and its constituent elements are never spread out over the sac as in the oblique form. A direct hernia is rarely found in young people, and there is often a considerable amount of subperitoneal tissue covering the sac. The External Direct Hernia is very similar in nature to the acquired oblique form, except that it is placed to the inner side of the deep epigastric artery, and pushes in front of it the trans- versalis, instead of the infundibuliform, fascia. It lies to the HERNIA 979 outer side of the conjoined tendon, and has a less complete cover- ing of the cremaster muscle. The Internal Direct Hernia issues from the abdomen to the inner side of the obliterated hypogastric artery, rupturing or pushing before it the conjoined tendon, which in such a case is poorly developed. The coverings are the same as for the external variety. Interstitial Hernia is the name given to an inguinal hernia which does not follow its usual course, but develops in some abnormal relation to the abdominal wall. Three varieties are described : (a) Where a sac exists between the transversalis fascia and the peritoneum {intraparietal form, or pro-peritoneal hernia), either with or without a hernia in the usual position ; in the former instance one form of ' hernia en bissac ' is produced. This abnormal pocket of the sac is found either between the symphysis pubis and the bladder (hernia inguinalis ante-vesicalis), or it extends outwards towards the iliac fossa (hernia inguinalis intra-iliaca). As no ex- ternal swelling is caused by this condition, it is usually impossible to recognise its existence prior to operation ; occasionally it is the cause of a continuation of the symptoms of strangulation, when apparently successful taxis has been performed, owing to the strangled bowel being pushed backwards from the superficial into the deeper portion of the sac. (b) An abnormal expansion or bulging of the sac is situated between the internal and external oblique muscles (interparietal form). A swelling is thus pro duced in the region of the inguinal canal, covered by the external oblique aponeurosis, and tending to spread upwards and outwards parallel with Poupart's ligament. The sac is often shaped like an hour-glass, a more or less complete septum existing at the level of the external abdominal ring, formed either by adhesions or by a mass of adherent omentum. The usual downward course of the hernial contents is thus prevented, and the sac yields laterally above the site of the obstruction, and passes between the muscles. (c ) The hernia escapes as usual from the external abdominal ring, but travels outward along Poupart's ligament, somewhat simu- lating a femoral hernia iextraparietal variety). This form is generally associated with late descent of the testis, and a con- tracted state of the scrotum, so that it is easier for the hernia, which is always of a congenital type, to pass into the thigh, and be guided by the fascia in the direction indicated ; in a case of this character operated upon a few years back, the testicle was found lying close to the anterior superior iliac spine. There is no difficulty in recognising such a condition. The Signs of an inguinal hernia do not require much special notice here, as we have already described the general clinical features of a rupture (p. 974). In the early stages, where merely a bubonocele exists, a fulness is noted in the course of the inguinal canal, which increases when the patient coughs ; it is 980 A MANUAL OF SURGERY best detected by a finger passed through the external ring into the canal. When it descends into the scrotum, the swelling increases in size from above downwards, and in the oblique variety is continuous with the fulness in the inguinal canal. The structures of the cord are masked by the presence of the hernia, but the testicle is to be more or less distinctly felt at the lower and back part of the swelling. When of the direct variety, the cord lies to the outer side, and although the hernia can be felt projecting from the external ring, it passes directly backwards, and there is no fulness along the course of the canal. Inguinal hernia is usually met with in the male sex, the oblique variety being more common in the young, and the direct in elderly patients. In the female sex it is rare, except in girls and young nulliparous women ; in such cases it is almost always congenital, passing into the labium along the canal of Nuck, but rarely attaining any considerable size. The Diagnosis of an inguinal hernia is a tolerably simple matter if it is uncomplicated by any other condition ; it may, however, be difficult, and in old-standing cases it is practically impossible to distinguish the oblique variety from the direct. The con- ditions for which it may be mistaken are best considered in two groups. I. Whilst the hernia is still incomplete and in the bubonocele stage, it has to be distinguished from the following : (a) Encysted hydrocele of the cord, which is recognised by its smooth globular outline and tense walls ; the impulse on coughing is less distinct, and, although freely moveable in the canal, the hydrocele cannot always be entirely reduced into the abdomen, whilst the charac- teristic gurgle of a hernia is absent ; traction on the testis, more- over, fixes the tumour, and renders it immobile. The exact limitation of the upper end of the swelling, if it can be reached, is very characteristic of a hydrocele, (b) A chronic abscess originating in the abdominal parietes, or within the abdomen or pelvis, will sometimes point through the external abdominal ring. In such cases, although there is a distinct impulse on coughing, and although the swelling is reducible, it has not the definite outline and characteristic sensation of a hernia, being usually soft and fluctuating. Other evidences pointing to the existence of the original disease may also assist in determining the nature of the tumour. (c) Enlarged glands in the groin which have become adherent to the external oblique are sometimes mistaken for a hernia, owing to the fact that on coughing a distinct impulse is communicated to them ; it is, however, merely heaving in nature, and not expansile, whilst on digital exploration of the inguinal canal the absence of a hernia may be readily ascertained, (d) A testicle retained in the inguinal canal is recognised by that side of the scrotum being empty, and on pressing the swelling testicular sensation may be elicited. The rounded upper end of the testes HERNIA 981 can often be detected, (e) Tumours consisting of fat or other tissues are occasionally seen in the inguinal canal, but are characterized by the strict limitation of their upper border, and usually by the absence of a distinct impulse on coughing. On the other hand, as described elsewhere, a mass of fat simulating a lipoma is sometimes present, resulting from a protrusion of the subperi- toneal tissue, a hernial sac being found embedded in its interior. (/) Hematocele of the cord is recognised by a history of injury, the presence of pain and ecchymosis, and the absence of an impulse on coughing, whilst reduction is impracticable. 2. When the hernia extends into the scrotum, less difficulty is ex- perienced in its diagnosis. By examination of the cord immediately outside the external abdominal ring, all purely scrotal swellings, such as hydrocele or sarcocele, are readily eliminated, since in them the cord can, in the early stages, be felt perfectly free. A varicocele can also be similarly recognised from an omental hernia by the condition of the cord in its upper region ; moreover, if Fig.. 354. — Inguinal Truss. (Down Brothers.) the patient is made to assume the recumbent posture, the swelling disappears in each instance, but if a finger is placed firmly over the inguinal canal so as to prevent any protrusion of omentum, and he is then directed to stand up, the swelling immediately reappears if it is venous in character. To the practised finger, the diagnosis is never a matter of difficulty, since the enlarged veins of a varicocele and omentum are not at all alike to the touch, the veins moving freely under the finger ' like worms in a bag.' When a hernia is associated with a hydrocele or sarcocele, a little more care is necessary in order to distinguish between the two swellings. The Treatment of inguinal hernia is either palliative by means of trusses, or radical. Palliative Treatment. — Many different trusses have been intro- duced in order to prevent the descent of a hernia. No one form is capable of dealing with every case, but the truss must be applied with care, so as to suit the special needs of the particular patient. It is impossible to describe a tithe of the varieties which have been suggested, and hence we must refer our readers to special works on the subject. Suffice it to indicate the essentials 982 A MANUAL OF SURGERY of a good truss. It should consist of a pad kept in position over the hernial aperture by a steel spring (Fig. 354) ; it must fit the patient accurately, resting behind on the middle piece of the sacrum, and passing laterally midway between the crest of the ilium and the top of the great trochanter. If the hernia is unilateral, the spring ends on the sound side just behind the anterior superior spine, and is prolonged anteriorly into a leather thong or cross-strap, which is secured to a stud on the pad. To prevent it from slipping up, an under-strap passes from the affected side close behind the anterior superior spine along the fold of the nates to the inner side of the thigh, being fixed finally to a second stud on the pad. The pad may be rounded or oval in shape, and usually consists of soft iron protected by cork, but polished vulcanite, wood, or an indiarubber cushion filled with air, water, or glycerine have been employed in- stead ; it should be well covered with leather, and the strength of the spring must be so adjusted as to retain the hernia under all conditions of strain to which it may be subjected, but without the use of undue force. In ordering a truss from an instrument-maker, the only measurement required is that around the body, following the line taken by the truss, and reaching in front to the symphysis pubis ; it is also advisable to mention the size of the hernia, and whether the opening in the abdominal parietes is large or small. In the earlier cases of oblique hernia, the pad should rest rather over the inguinal canal than over the external abdominal ring, the object being to restore the valve-like action of the canal by approximating its sides. In a direct hernia the pad must be applied directly over the opening. If such an apparatus is properly adjusted and continuously worn, a cure is sometimes established in the course of a year or two, and in cases of con- genital hernia in children a cure may be confidently expected if the mother or attendants of the child conscientiously carry out the necessary details. If the hernia is once allowed to slip down, even after six or twelve months' treatment, all the previous good will have been undone. In infants, an efficient support is afforded by a skein of wool (specially known as ' fingering '), divided at one end, so that when placed round the body the cut ends of the skein can be passed through the loop, forming a knot over the inguinal canal, which acts as the pad of a truss. The cut ends are now passed under the perineum, and tied to the transverse portion behind (Fig. 355). Fig. 355. — Wool Truss for Treatment of Hernia in Children. HERNIA 9S3 This apparatus is changed night and morning when the child is bathed, and also, if need be, at shorter intervals, the mother being previously instructed as to how to support the hernia whilst the apparatus is being removed. In cases of double rupture in infants an indiarubber band with two pneumatic air-pads (Fig.356), arranged so as to fit over the inguinal canals, and with suitable straps and studs, will often suffice, and is certainly more comfort- able than a spring truss. In addition to such pressure, it is im- portant to remove all causes of intra-abdominal tension, as by cir- cumcision, where phimosis is present, or by regulating the bowels. The Radical Cure of inguinal hernia is an operation to which much attention has been directed of late years, since its value was brought prominently before the profession by the late Professor John Wood and others. It is very largely employed at the present day, though there are still surgeons who only advocate its use under exceptional circumstances, appealing to the frequent recurrence after operation as an argument against its adoption. Whilst fully admitting that recur- rences are more frequent than they should be, we look on them as either being due to an error of judgment in the selection of the cases for operation, or as resulting from imperfect technique, or from inefficient after-treatment. The selection of cases for an operation of this type, which is not an essential, but only a desirable means of treatment (or, as it is sometimes termed, an operation de complaisance), is a matter requir- ing considerable judgment and discrimination. In an individual whose occupation does not subject him to heavy strain or exer- tion, and who possesses a hernia which, under ordinary circum- stances, is easily commanded by a suitably applied truss, no operation is absolutely necessary ; although one is perfectly justified in urging him to submit to it, since he will be thereby freed from the irksomeness of wearing a truss, and from the risks of possible strangulation. If, however, the subject is a labouring man, exposed to injury and strain, and who may find it difficult to provide a suitable series of trusses, the operation should always be undertaken unless distinctly contra-indicated (1) by a general inherited weakness of the abdominal muscles ; (2) by a relaxed and atonic condition of the abdominal parietes, which is so commonly associated in elderly people with slipping downwards Fig. 356. — Indiarubber Band Truss, with Air-pads, for Infants. The air-pads fit around the root of the penis, and are inflated through the tube tied up in front. The under- straps fit round the child's thighs. 984 A MANUAL OF SURGERY of the mesenteric attachment of the intestine (enteroptosis), so that the hypogastrium obviously bulges ; or (3) by such con- stitutional disease as precludes all unnecessary operative inter- ference. (4) Again, in cases of extensive irreducible hernia, the return of large masses of intestine which have lain for years in the hernial sac so increases the intra-abdominal tension as fre- quently to determine recurrence locally or elsewhere, and therefore operative interference, though very desirable owing to the great risk of strangulation incurred by the patient, is often followed by very bad results, unless the patient has previously been put through a course of semi-starvation and persistent taxis in order to gradually reduce the size of the protrusion. As to the best age at which to operate, statistics definitely prove that it is essentially an operation of adolescence, the results gradually getting worse as the age increases. Young children should not be touched until careful truss pressure for a year has failed, or unless it is impossible to keep up the hernia by such treatment. In any case it is perhaps wiser to delay it until the age of three, owing to the risk of infection of the wound from the constant saturation of the dressings with urine. Very many different operations have been described and practised by various surgeons ; in all probability some of them are unnecessarily complicated, and can only be briefly alluded to. The plan we now employ in almost all cases is known as Bassini's operation ; it appears to us as one of the most scientific of all those that have been suggested, since it reproduces more accurately than any other the normal structure of the parts. The instruments required are scalpels, forcipressure forceps, dissecting forceps, re- tractors, transfixion needle, curved hernia needles, and scissors. The operation may be described in the following stages: (1) The pubic region having been previously shaved and thoroughly purified, an incision is made in the direction of the inguinal canal and cord, about o.\ inches in length, its centre being a little above the external abdominal ring. This is carried through the skin and subcutaneous tissues until the structures of the cord are reached, the superficial external pudic artery being necessarily divided en route ; the pillars of the ring are clearly defined, and the external oblique aponeurosis slit up for about f inch beyond the apex of the ring in the direction of the cord. (2) The sac has now to be identified ; if the hernia is one of old standing, or contains adherent omentum or intestine, it is easily recognised ; but if it is thin, empty, and of recent formation, and especially in the case of a bubonocele, its identification may be a matter of some difficulty. The structures of the cord are lifted up out of the wound, spread out over the fingers, the coverings divided, and the white convex border of the fundus of the sac looked for. It is sometimes necessary to induce vomiting by titillation of the fauces, in order to cause the hernia to protrude, particularly when it is of the direct type. (3) If the sac is empty, it is freed from its connection HERNIA 985 with the structures of the cord without opening it, and isolated as far as or beyond the internal abdominal ring, as indicated by a collar of fatty subperitoneal tissue surrounding the neck. If the hernia is irreducible, the sac is laid open, its contents freed from adhesions, and the intestine returned into the abdomen, whilst omental tissue is removed, and the stump replaced. The greatest gentleness must be employed in dealing with the intestines ; if a considerable amount is present, it must be surrounded by a cloth wrung out of warm sterilized salt solution. Adhesions are care- fully divided either by the finger or between ligatures ; if closely Fig. 357. — Bassini's Operation for Radical Cure of Hernia. A and A 1 , Spencer Wells's forceps, holding aside the divided portions of external oblique aponeurosis ; B, arched fibres of internal oblique, continuous on the inner side with the conjoined tendon ; C, hook or retractor holding aside the spermatic cord ; D,D,D,D, deep silk stitches passed behind the cord through the deepest fibres of Poupart's ligament on the outer side, and conjoined tendon on the inner. (The cutaneous incision and the incision through the external oblique are here shown much greater than would actually be undertaken, in order to demonstrate clearly the deeper parts.) adherent to the sac, it may be necessary to leave a small portion of this attached to the gut, which is then returned. Omentum, whether adherent or not, should be removed, as the elongated fringes are very liable to contract adhesions to the abdominal parietes, and subsequently produce mischief. In removing omentum, it is not advisable to encircle a large mass with a single ligature, as the vessels are less securely commanded, and a pocket or pucker may be produced, possibly leading to internal strangulation at a later date. Small portions, including one or more of the larger vessels, should be taken up one after another, 986 A MANUAL OF SURGERY and tied separately and with advantage at different levels, so as to assist in the subsequent return of the stump. The protruded mass is then cut away below the ligatures, and the stump replaced after seeing that no bleeding point remains unse- cured. The sac, being now emptied, is isolated as far as the internal ring. (4) The neck is then transfixed as high as possible, and ligatured with sterilized silk, and the sac cut off below the ligature, the stump retracting well above the internal ring, and presenting a flush surface towards the intestines, as we have been able to demonstrate in a recent post-mortem specimen, obtained from a patient who died of pulmonary embolus ten days after operation. (5) The tissues of the cord are carefully ex- amined, and any varicose spermatic veins removed, as also any downgrowths of the subperitoneal fat and possibly portions of the cremaster. (6) The opening in the abdominal parietes is closed by a row of sutures passing through the arched fibres of the internal oblique and transversalis muscles, or through the con- joined tendon on the inner side, and through Poupart's ligament on the outer, the stitches being all placed behind the cord. To effect this, the cord is drawn up out of the wound and held aside by a retractor (Fig. 357, C), whilst the divided margins of the external oblique aponeurosis are grasped by pressure forceps (A, A 1 ). Gentle traction on the lower pair enables the deepest portion of Poupart's ligament to be defined and seen. The stitches must secure a good hold of the tissues, but should not include the external oblique aponeurosis, and when dealing with Poupart's ligament the proximity of the iliac vessels must not be forgotten. It is wise to utilize interrupted stitches and not looped or mattress sutures as recommended by some authorities, since the latter tend to strangle the portions of tissue included in their grasp. The opening in the abdominal parietes is in this way commanded as far down as the pubic spine, but sufficient room must be left at the upper end for the passage of the cord, undue constriction of which would cause atrophy of the testis ; some- times it is desirable to introduce a stitch above the cord, in order to command a spot where recurrence is not uncommon. When the three or four needful stitches have been introduced and tightened, the cord is replaced, and the divided portions of the external oblique are sutured together over it, (7) The wound in the skin is closed by a continuous suture, and usually no drainage- tube is needed. After-Treatment. — The patient is placed in bed with the head low, and the knees slightly flexed over a pillow. The wound, as a rule, does not require dressing for seven or eight days, when, on removal of the stitches, it should be found completely healed, if asepsis has been maintained. The patient should turn to the opposite side in order to pass water, and the greatest care must be taken to prevent the dressing becoming soiled. Occasionally retention of urine follows this operation, necessitating the use of HERNIA 987 a catheter. In the case of children, it is well to seal the parts down by a collodion dressing, and by preference the collodion should be of the flexile type, but with the guncotton replaced by celloidin (cello id in collodion). The recumbent posture should be maintained for three weeks, and nothing but the slightest work undertaken for at least six weeks, and no violent effort until six months after the operation. Under such circumstances the use of a truss is unnecessary, and, indeed, we consider that it is undesirable, as its pressure is liable to produce atrophy of the newly-formed cicatricial tissue. When, however, the abdominal walls are congenitally weak, or if, unfor- tunately, the wound has suppurated, the deep stitches coming away, it is advisable to use a light truss for a time. The treatment of congenital hernia differs in no particular from that already described, except that the sac must be divided below as well as above, and the lower opening secured by suture or ligature, so as to close the cavity of the tunica vaginalis. The operation often proves difficult owing to the intimate adhesions between the sac and the structures of the cord, and it is some- times impracticable to completely isolate the neck of the sac. In many cases the old-fashioned Mitchell Banks' operation suffices for a congenital hernia. The other operations which require to be mentioned are as follows : (a) In Mitchell Banks' Operation, the sac is isolated and removed as high as the internal ring without any division of the external oblique. Stitches are then introduced through the conjoined tendon and Poupart's ligament respectively, including the external oblique in their grasp, and passing in front of the cord. It is obvious that by such a plan the deep ring cannot be closed as accurately as in Bassini's operation. It may suffice, however, in a few of the simpler congenital cases. (b) Ball's Operation consists in freeing the peritoneum on the inner aspect of the internal abdominal ring, and then the sac, after being isolated, is twisted into a tense cord, so as to throw it into a series of folds, thereby producing a prominence internally rather than an infundibuliform depression. To prevent untwist- ing, a ligature is tied around it as high as possible, and it is also transfixed below the ligature by a thread, the ends of which are passed through the abdominal parietes. (c) In what is known as Barker's Operation the neck of the sac is isolated, ligatured, and divided, the fundus being left in situ, whilst the thread used in tying the neck is employed as the first suture to close the deep part of the canal ; by this means it is hoped that the neck of the sac will be displaced, and hence more satisfactorily occluded. It is very doubtful, however, whether this really occurs. (d) In Macewen's Method the aponeurosis of the external oblique is most carefully maintained intact, and the inguinal canal is A MANUAL OF SURGERY explored through the external abdominal ring. The sac is freed from its surroundings, and this liberation goes on for about an inch all round the internal abdominal ring. A silk suture is then tied to the fundus of the sac, and is carried by a curved needle through the centre of the sac from above downwards and again through the neck of the sac from below upwards. The needle is then introduced through the inguinal canal under the loosened abdominal parietes, and is made to emerge through the abdominal muscles a little above the inguinal canal; the silk thread is carried through this, and by a little traction the sac is carried in, doubled up, and implanted as a pad across the internal ring. This thread is held by an assistant during the next step of the operation. This consists in closing the canal by one or more looped sutures, passed in such a way as to draw up Poupart's ligament over the arched fibres of the internal oblique in front of the cord. Finally, the thread used for the fixation is drawn tight, and its free end employed to close the external abdominal ring to a sufficient extent. The results of this proceeding are very good, but it is a more diffi- cult operation than Bassini's, and one loses the advantage of opening the canal more freely, and thereby exploring the structures of the cord. One is frequently finding subperitoneal lipomata in the canal, and these would inevitably be left, and would possibly lead to a recurrence of the hernia, if the canal had not been opened up. (e) Halsted's Operation is much the same as Bassini's, except that the fibres of the internal oblique are also divided at the outer margin of the internal ring, and the cord displaced upwards and outwards through this opening, so that at the spot at which it pierces the abdominal parietes it may be surrounded by muscular fibres. The canal is then closed as in Bassini's operation, whilst the external oblique is also sutured behind the cord, which is thus made a subcutaneous structure. We see no special advantage to be gained by this departure from Nature's method of conducting the cord and its structures through the abdominal wall in an oblique direction. Recurrence after Operation is unfortunately met with only too frequently, and statistics go to prove that in the great majority of cases it happens within the first twelve months. As already stated, it may be due partly to an injudicious selection of cases, partly to errors of technique, and in part to a faulty after- treatment, the patient being given too much liberty at too early a date. In connection with this we would especially emphasize the necessity for isolating the sac as far as possible, since otherwise the infundibuliform opening at the top of the closed peritoneal canal is certain to persist. Another not uncommon cause of recurrence is septic contamination of the wound ; if the deep stitches are not involved, no great harm is done, but whenever they have been removed or come away it is wise to use a truss subsequently as a precautionary measure. Again, the mere restoration of a mass of intestine or omentum into the abdominal HERNIA 989 cavity may suffice to raise the intra-abdominal pressure, and thus predispose to a recurrence ; hence the importance of removing as much omental tissue as possible in all bad cases. Relapses may also be due to splitting or tearing of the tendinous structures around, either by the mere passage of the needle, or by the traction induced by tightening the sutures ; indeed, it is often the case that a hernia originally oblique may after operation be followed by one that is direct, and probably from this cause. Whenever it appears likely that recurrence may occur, a truss should be ordered. If, however, a hernia has developed, a second operation should be performed, if the condition of the abdominal parietes warrants it. Femoral Hernia. — A femoral hernia is one which, travelling down the crural canal, presents at the inner and upper part of the thigh through the saphenous opening. It occurs most commonly in women, on account of the greater expansion of the iliac crests allowing increased space beneath Poupart's ligament, and especi- ally in those who have borne children,. During parturition the inguinal regions are in a measure protected, and hence inguinal hernia is rarely caused in this way. The crural canal constitutes the inner compartment of the femoral sheath, a space usually occupied by fatty cellular tissue, lymphatic vessels, and perhaps a lymphatic gland. It is about f inch in length anteriorly, and 1 \ inches along its posterior wall ; it is closed above by a thickened portion of the subserous cellular tissue known as the septum crurale, and its lower end is formed by the saphenous opening, and closed by the cribriform fascia. Hence a femoral hernia, as it passes downwards, receives the following coverings: (a) peritoneum ; (b) subserous cel- lular tissue, including the septum crurale, a layer sometimes known as the fascia propria, and occa- sionally represented by a thick fatty envelope ; (c) the anterior layer of the femoral sheath, derived from the fascia transversalis ; (d) cribriform fascia ; (e) subcutaneous tissue ; and (/) skin. In its passage it is situated immediately internal to the femoral vein, and pressure upon this may produce cedema of the leg, whilst Gimbernat's liga- ment lies to the inner side of the neck of the sac. The spermatic cord or round ligament passes just above and internal to it, but on a superficial plane, whilst the epigastric artery is not very far from the outer side of the neck. Occasionally the obturator artery arises from this latter vessel (once in three and a half subjects) ; it either passes to the Fig. 358. — Femoral Hernia. 99Q A MANUAL OF SURGERY inner side of the neck of the sac along the border of Gimbernat's ligament (once in seventy-five times), but more commonly runs between the neck and the femoral vein. When once it has emerged from the saphenous opening, a femoral hernia tends to pass upwards and outwards along Poupart's ligament towards the anterior superior iliac spine, being guided by the attachment of the deep layer of the superficial fascia ; when of large size, it may extend considerably above the level of Poupart's ligament. Femoral herniae are less likely to contain omentum than the inguinal variety : a portion of the ileum is most often present, but occasionally the ovary or Fallopian tube may be found in the sac. The Signs of a femoral hernia are very characteristic. A swelling with an impulse on coughing, and more or less reducible, forms on the inner side of the thigh, its neck or aperture of com- munication with the abdomen lying to the inner side of the femoral vessels, and to the outer side of the pubic spine, which can always be felt (Fig. 358). There is usually but little difficulty in making a diagnosis, although occasionally considerable care is needed, and especially in distinguishing it from the following conditions : (a) From inguinal hernia, which is more common in young males, its neck occupying the inguinal canal, and the saphenous opening being free ; whilst it is also above and internal to the pubic spine, and above Poupart's ligament at its point of exit ; it tends to pass downwards into the scrotum, or in females into the labium. Femoral hernia, on the other hand, usually (but not invariably) occurs in women over twenty-five years of age ; the inguinal canal is free, whilst the neck is in the situation of the crural canal, below and external to the pubic spine, and below Poupart's ligament ; moreover, it travels upwards and outwards, the labium being unaffected, (b) An enlarged lymphatic gland over the saphenous opening may simulate this condition very closely ; but the absence of impulse on coughing and of the usual hernial signs is generally sufficient to distinguish it ; when, however, the hernia is purely omental and irreducible, the impulse is so slightly marked that correct diagnosis in a stout woman is often difficult without an exploratory incision, (c) A small lipoma in the canal somewhat resembles a hernia, but the limitation of the tumour, its greater mobility, and the absence of an impulse on coughing, should suffice to prevent any mistake. (d) A psoas abscess pointing at the saphenous opening resembles a hernia in the existence of a reducible swelling with an expansile impulse on coughing. It is distinguished from it by the facts that there is no gurgle on reduction ; that the abscess, as it passes under Poupart's ligament, lies to the outer side of and behind the vessels ; and that distinct fluctuation occurs between the swelling in the saphenous opening and the tumour, which can always be felt in the iliac fossa ; the characteristic signs of spinal caries are also usually present, (e) In vavix of the saphena, if a pouch or so-called ampulla forms close to its entrance into the femoral vein, it may be mis- HERNIA 991 taken for a femoral hernia on account of the marked impulse on coughing, and because the swelling disappears on assuming the recumbent posture. It is, however, usually associated with the signs of varix below, and by the fact that, although pressure is made over the upper part of the crural canal after the vein has been emptied, the swelling regains its ordinary size when the patient stands up. Treatment. — When reducible and of small size, a femoral hernia may be treated by the use of a truss, similar in nature to that used for an inguinal hernia, except that the pad extends some- what lower, so as to maintain pressure along the course of the canal. A badly fitting truss may compress the femoral vein, and lead to cedema of the leg. Operative Treatment is undertaken either for the relief of strangulation, or, if a radical cure is desired, as an operation de complaisance. The remarks already made as regards the cure of inguinal hernia, and the general principles there enunciated, apply also to this variety. Two main methods of operating are em- ployed : (a) The sac is exposed by a vertical incision along the course of the crural canal, emptied of its contents by reduction of intestine and removal or reduction of omentum, and cut away after transfixing and tying the neck. The deep ring is then com- manded by one or two sutures passed vertically between the fascia over the pectineus and the inner end of Poupart's ligament ; this must, however, not be tied too tightly, for fear of constricting the femoral vein, (b) W'atson Cheyne recommends that a portion of the pectineus muscle should be dissected up, and fixed in the crural canal by means of sutures ; and he claims thereby to have had very satisfactory results. The same precautions as to after- treatment must be adopted as in inguinal hernia. Umbilical Hernia. — Three different forms of umbilical hernia are described. 1. Congenital Umbilical Hernia, or Exomphalos, is an exceed- ingly rare condition, due to imperfect closure of the abdominal walls, as a result of which the intestine is not entirely withdrawn into the abdomen at birth, but is found in a cavity at the base of the umbilical cord, which is bulbous and enlarged. If the con- dition is overlooked, it may be included in the ligature with which the cord is tied, and fatal strangulation, or at the best a faecal fistula, will result. If left untreated until the cord has separated, the peritoneal cavity will be laid open, and septic peritonitis ensue. The only treatment is immediate laparotomy, reduction of the gut, and closure of the umbilical opening by sutures. 2. The Umbilical Hernia of Infants and Young People, or, as it is commonly called, ' starting of the navel,' is due to weakness of the umbilical cicatrix, which yields before the intra-abdominal pressure. Its occurrence is often determined by chronic consti- pation or phimosis, necessitating continual straining in order to 992 A MANUAL OF SURGERY evacuate the bowels or bladder. The condition rarely persists till adult life is reached, and it is readily amenable to treatment. This consists in regulating the bowels, the performance of cir- cumcision, if necessary, whilst the local condition is dealt with by strapping the abdominal wall in such a way as to tuck the umbilical cicatrix inwards ; no pad is required. In persistent cases it may be necessary to lay the sac open and remove it, suturing the parts together, as described in detail below. 3. The so-called Umbilical Hernia of Adults is usually due to a protrusion of omentum or intestine through an opening in the linea alba, either immediately above or below the umbilicus, the former being the more common. It occurs most frequently in women who have borne children, being sometimes due to actual rupture of the linea alba and separation of the recti muscles. In such cases it is possible that the peritoneum is also torn, and the intestines extravasated, as it were, beneath the skin. A peritoneal sac, is, however, usually seen, but in old-standing cases it is ex- tremely attenuated, and so adherent to surrounding parts as to be unrecognisable, whilst the contents may be matted together in an almost inextricable confusion. In such cases obstruction is very liable to ensue, and if combined, as is not uncommon, with a subacute form of inflammation, it may even run on to strangula- tion. Moreover, the skin over the tumour becomes stretched, atrophic, and not unfrequently ulcerated, so that perforation may threaten. The hernia is often lobulated in character, and a con- siderable deposit of fat may sometimes surround it. Treatment. — When of large size, and occurring in stout indi- viduals, it should be supported by a bag truss, whilst the patient is placed on such dietetic and hygienic measures as shall assist in the reduction of excessive corpulency. In favourable cases operative treatment can be undertaken. A vertical incision is made over the site of the tumour, and to effect this without wounding the subjacent gut, it may be advisable to pinch up the skin on either side, and cut it by transfixion. The sac is then opened, the incision being enlarged, if necessary, so as to allow the contents to be drawn aside and the opening in the abdominal wall exposed. When the intestine has been reduced and omentum removed, the sac is dissected up to the margins of the opening into the abdomen, which is usually small in size and circular in shape, whilst the edges are firm and thickened. The sac may now be cut away close to the opening, and all bleeding-points secured. The aperture is then closed in the following way : Several deep transverse sutures are passed through the whole thickness of the abdominal wall on each side, and tightened after a row of inter- rupted sutures has drawn the peritoneal surfaces into contact. By this means the circular aperture is obliterated and the margins united in the median line. The external wound may now be closed, any redundant skin being cut away ; it is usually safer to insert a drainage-tube in the more extensive cases. HERNIA 993 Most surgeons recommend that the fibrous margins of the deep opening should be freely removed by dissection before the passage of the sutures, so as to expose the fibres of the recti muscles, and permit of their approximation after the peritoneum has been turned in and stitched ; the suggestion is a good one, since the union of healthy vascular tissue must always be more favourable than that of two anaemic cicatricial edges. To accomplish this satisfactorily, it is often necessary to prolong the incision up and down for some distance, since the recti muscles are usually displaced laterally and must be freely detached from their sheaths if they are to be brought together in the middle line. Silkworm gut may be used with advantage in these cases for the deep sutures, since it remains unabsorbed. A Ventral Hernia is the term used in describing any protrusion occurring at some spot in the anterior abdominal wall other than those already mentioned. Several forms may be met with : 1. It not uncommonly consists of a protrusion of subserous fatty tissue through a congenital or acquired opening in the linea alba, lineae semilunares, or lineas transversa?, especially at the junctions of the former and latter. They are more common above than below the umbilicus, and if, as not unfrequently happens, the fatty tissue proliferates, a localized tumour resembling a lipoma is produced, and goes by the name of a ' fatty hernia of the linea alba.' A portion of peritoneum is drawn through the opening into the centre of these masses when they have persisted for some little time, and a true hernia is thus induced. A similar condition is met with in the inguinal and crural regions, and probably most of the cases described as lipomata in these parts are of this nature. Considerable pain and abdominal disturbance (vomiting, colic, etc.) accompany almost every movement of the body, being caused partly by the traction of the peritoneum, partly by the constriction of the neck of the sac against the sharp edges of the small opening. Treatment consists in the removal of the projecting mass, care being taken not to include any viscera in the suture with which the base is surrounded. The stump is pushed back into the abdomen, and the opening closed by deep sutures. 2. After operations involving the division of the abdominal parietes, ventral hernia may be caused by the yielding of the cicatrix, especially if the wound suppurates, and the deep stitches come away or are removed, or if the opening is left patent for the purpose of draining an intra-abdominal abscess. Treatment of such cases consists in dividing the skin and subjacent fibrous tissues, defining and refreshing the edges of the parietal wound, and drawing them together with buried sutures. The peritoneum need not always be opened in such a procedure, but it is sometimes wiser to do so. Especially is this the case when a ventral hernia forms after an operation for suppurative appendicitis ; the appendix is rarely dealt with at the primary operation, and the surgeon may rightly take the opportunity of removing it during the operation required for the cure of the hernia. 3. Not unfrequently in women who have had children the linea alba stretches and yields, allowing considerable separation of the recti muscles for almost their whole length. If placed in the recumbent posture, and told to raise their head and shoulders from the bed without using their elbows for support, the linea protrudes as a longitudinal ridge of considerable breadth. Much discomfort and dyspepsia arises from this cause, owing to the inefficient support given to the intestines. A firm abdominal belt may be useful as a palliative measure, but operation is very desirable. The thinned linea alba is split down the middle from top to bottom if need be ; on one side — say the right — it, together with the neighbouring rectus muscle, is separated from the subcutaneous tissues and tucked under the rectus on the left side, its free end 63 994 A MANUAL OF SURGERY being secured by mattress sutures passing through it and the left linea semi- lunaris, and being tied superficially. The left free edge is subsequently secured to the right linea semilunaris by a row of stitches. In this way the abdominal wall is drawn together like a double-breasted coat, and excellent results follow. A Lumbar Hernia is a condition of considerable rarity, in which the abdominal viscera protrude by the side of the erector spinas, coming to the surface between the latissimus dorsi and the external oblique, in the space known as Petit's triangle. The ordinary signs of a hernia are present, and with a little care the condition is readily distinguished from a lumbar abscess. Treatment may be conducted along the same lines as for a ventral hernia. A Diaphragmatic Hernia is rarely recognised ante-mortem. A few cases of strangulation have, however, been diagnosed. It is usually congenital in origin, arising from imperfect development of one or both halves of the diaphragm ; it is most common on the left side. It may, however, result from traumatic lesions, such as stabs, involving the diaphragm. The transverse colon or stomach generally protrudes into the thorax, and there is usually no peritoneal sac. Treatment is impracticable in the majority of instances, although one or two cases of traumatic hernia have been successfully operated on through the chest wall and pleural cavity, thus permitting the closure of the hole in the diaphragm. Obturator Hernia consists in a protrusion of intestine through the upper part of the thyroid foramen, and has usually been observed in elderly females. It is not often recognised in the living, except when strangulated, and even then, unless of considerable size, it is likely to be overlooked. It has, how- ever, been diagnosed by the fact that, in addition to the general signs of strangulation, there was a sense of deep resistance and of fulness close to the origin of the adductor muscles ; whilst pain was referred down the obturator nerve to the inner side of the knee. Rectal or vaginal examination may throw some light on the nature of the case. Treatment has generally been confined to cases of strangulation, and in such an incision is made over the inner aspect of Scarpa's triangle, and the pectineus divided or displaced. The sac when found should be opened, and strangulation relieved by cutting upwards, the obturator vessels being usually situated below the neck of the sac. Other forms of hernia, e.g., pudic, pudendal, vaginal, sciatic, etc., have been described, but are so uncommon that they need no special mention. Abnormal Conditions of Hernise. Irreducibility of a Hernia is generally due to the presence of adhesions, either between the contents and the sac, or between the contents themselves, which are thus united into a mass too large to pass through the aperture of communication with the abdomen. This is often associated with contraction of the neck of the sac, which arises either from the pressure of an ill-fitting truss or the constant drag of the contents. Overgrowth or an excessive deposit of fat in the omentum may result in irreduci- bility, whilst cysts may occasionally form, as already described. The local signs of this condition are very evident, whilst dys- pepsia, colicky pains, and a sense of dragging are among the most prominent symptoms. Treatment. — i. It may sometimes be remedied by forcible taxis applied at intervals, between which the patient is kept in bed, and an icebag applied so as to contract the parts ; moreover, the patient, if fat, should be carefully dieted. It is most important HERNIA 995 not to operate on large herniae of this nature until some such preliminary treatment has been undertaken ; the sudden reduction of a large amount of intestine into the abdominal cavity has been responsible for several deaths from interference with the heart's action. 2. Another plan consists in the use of what is known as the hinged-cup truss ; the hernia is supported in a suitable leather bag hinged to the lower part of a truss, upward pressure being maintained by means of an elastic spring. By the use of one or other of these plans reduction may after a time be accomplished ; but we are not in favour of any such proceedings, except in very large herniae. 3. In healthy individuals, and if the rupture is not too large, operation is preferable and much more satisfactory, omentum being removed and adhesions divided, as already de- scribed (p. 986). 4. In a few very aggravated cases, it is only possible to support the hernia by an elastic bag. Inflamed Hernia is one characterized by the existence of a localized peritonitis involving the sac, and perhaps also the con- tents. It usually arises from injury, such as ill-directed taxis, or from injudicious truss pressure. The symptoms are those of a local inflammation, the part becoming hot, painful, tender, and swollen, and perhaps the skin over it red; this is associated with general fever, malaise, nausea, and vomiting, whilst constipation is usually present. A condition is thus induced somewhat re- sembling strangulation ; but it is distinguished from the latter by the presence of fever instead of shock, the absence of tension in the sac, and the character of the vomiting, which is not faecal. The hernia is irreducible, at any rate for a time, probably more on account of the pain, which prevents taxis, than from any mechanical reason, except in old-standing cases where previously formed adhesions exist. Lymph is deposited on the serous surfaces, and this usually leads to the formation of adhesions. Occasionally, where omentum is alone present, an attack of this type may result in a natural cure, especially in the umbilical variety. The Treatment consists in putting the patient to bed and re- stricting his diet to fluids, whilst fomentations are applied to the part. A little opium may also be administered to allay the pain, and possibly the lower bowel emptied by an enema. Obstructed Hernia is a condition in which the onward passage of faeces through the gut contained in a hernial sac is prevented. It is most frequently seen in the umbilical variety, and is of course irreducible. It is due to an accumulation of undigested food or faeces, the condition being aggravated by the presence of flatus derived from the decomposition of the contents of the bowel. Nausea and vomiting are induced, the latter, however, rarely becoming fasculent, whilst constipation is usually present, although the lower bowel may empty itself and flatus may pass. Locally, the tumour becomes distended, but not tense as in strangulation, and a doughy mass, which can be moulded and indented by the 63—2 99 6 A MANUAL OF SURGERY fingers, is felt within the sac. There is no tenderness, but the patient usually complains of a good deal of intermittent colicky pain. If unrelieved, a subacute form of inflammation may super- vene, and this may pass on to strangulation, and even death. Treatment consists in the use of copious enemata, and the application of an icebag to the hernia, followed by carefully applied taxis, so as to assist the onward passage of the impacted contents. As soon as the obstruction is overcome, a brisk purge should be administered. Strangulated Hernia. A hernia is said to be strangulated when the contents are con- stricted in such a way as to obstruct and ultimately arrest the flow of blood in the vessels contained therein. Interference with the passage of faeces is not an essential in this condition, since omentum alone may be involved, or the intestine, if present, may only have a portion of its lumen constricted, as in the form known as Kichter's hernia, or in Littre's hernia, where a diverticulum is similarly affected. Two chief varieties of strangulation are described : those occurring within the abdomen, which are dealt with more fully in Chapter XXXIV., and those which are extra-abdominal ; it is only the latter to which we shall now direct attention. External Strangulated Hernia arises in one of two ways : (a) The hernia becomes strangulated immediately after its formation ; this is most frequently seen in children or adolescents, the hernia being then of the congenital type, and having a long narrow sac. (b) In adults it more frequently results from ex- trusion of an additional amount of the abdominal contents into the sac, as the result of some sudden violent effort. This condition usually obtains in old-standing herniae, the neck of the sac having previously become thickened and contracted, either by the pressure of a truss or the irritation of the protruded viscera. The former of these two conditions is usually acute in character, the latter more often subacute. The site of the constriction is either at the neck of the sac, or in the dense tissues external to it, but occasionally it exists else- where. Most frequently the active agent in the strangulation is the thickened sac wall itself ; but in femoral and umbilical herniae structures outside the sac, such as Gimbernat's ligament or the linea alba, may be the actual cause of the constriction, whilst it may also be produced by the passage of a coil of intestine under a tight adhesion or through a slit or aperture in the omentum contained in the sac. In those herniae which become strangulated immediately after their protrusion, the constricting cause is in- variably the resistance of the tissues surrounding the opening in the abdominal parietes. Pathological Phenomena. — The effects of strangulation vary HERNIA 997 somewhat with the tightness of the constriction. The circulation is seldom entirely arrested at the onset of the symptoms ; but the pressure affects first, and more especially, the veins, and later, by the congestion and exudation thus produced, the flow in the arteries is brought to a standstill. Hence the constricted tissues are congested to begin with, and pass over into a state of gangrene with or without an intermediate period of inflammation. When a portion of intestine is strangulated, the following changes manifest themselves in its structure and appearance. At first it becomes of a dusky red, chocolate, or claret colour, owing to vascular congestion ; it is thickened and stiff from exudation into its walls, and distended by the formation of gas within its lumen, owing to the arrest of peristalsis and the putrefaction of its con- tents. The surface at first remains smooth and shiny, but as the exudation into the sac increases, the endothelium is usually shed. Occasionally some of the superficial capillaries rupture, giving rise to ecchymoses, whilst in rarer instances, and possibly as the result of injudicious taxis, the congested vessels completely empty them- selves into the sac, which is thus filled with clotted blood, the intestine in consequence becoming lax and yellowish -grey in colour. When the strangulation is relieved in this early stage, the bowel soon regains its former healthy appearance. If inflam- mation occurs, the surface becomes rough from the deposit of lymph, and entirely loses its shiny and polished aspect. Gangrene results partly from the prolonged stagnation of blood, and partly from the action of the Bac. coli, which, as soon as the vitality of the intestinal wall is sufficiently impaired, migrates through it, and by its development produces toxic bodies which still further assist the gangrenous process. As soon as it is established, the intestine turns an ashy grey or black colour, usually at one or more spots which gradually spread, lose all lustre and polish, and after a time become soft, lacerable, and offensive. At the point of strangulation the gut is completely anaemic and liable to ulceration, which may subsequently result in perforation ; adhesions may, however, form between it and the neck of the sac, thus preventing contaminaiion of the general peritoneal cavity. The intestine above the site of strangulation becomes paralyzed, and peristalsis is entirely arrested, even in a Richter's hernia. Faecal material, accumulating and undergoing decomposition, gives rise to a catarrhal enteritis, and even occasionally to stercoral ulcers, which may perforate and cause general peritonitis ; this, however, is not very common in external strangulation, since the small in- testine is usually involved, and solid faeces are absent. In more chronic cases gangrene of the gut may be induced by the pressure of the accumulated contents and the action of the Bac. coli. The portion of the bowel below the constriction may be affected in a similar manner, owing to the arrest of the peristalsis, but to a slighter decree. 998 A MANUAL OF SURGERY Omentum, when strangled, is at first congested and of a dark red or purplish colour, and later on infiltrated and matted together. If, however, it has contracted adhesions to the sac, and no gut is present, the trouble may subside, since its vitality may* be maintained through the adhesions, and a natural cure of the hernia may result. Where such a condition is not present, gangrene supervenes, and the omentum then becomes ashy grey or brown in colour, and is pultaceous and friable. It does not become offensive unless associated with intestine, since it does not contain any intrinsic source of putrefaction. The sac is usually distended with fluid, which at the commence- ment is serous in character, and perhaps blood-stained, whilst subsequently it becomes turbid and mixed with lymph ; finally, it is dark brown or yellowish-green, with a marked and most objec- tionable odour. Occasionally there is but little or no effusion of fluid, a condition more often met with when intestine is absent from the sac, and only omentum, or some solid viscus, such as the ovary, is present. The serous lining of the sac is but slightly affected in the early stages ; as, however, the case progresses to inflammation or death of the contents, it also becomes inflamed, and ultimately gangrenous owing to the action of the Bac. coli, which by this time has penetrated to the turbid serum contained within it. The skin and surrounding tissues become cedematous, congested, and crepitant, and, finally, a natural cure may be deter- mined by sloughing and the establishment of an artificial anus. After the relief of strangulation, even if no gangrene has occurred, the patient is not free from risk, owing to changes which may possibly follow the temporary arrest of the circulation. It has been shown by placing a ligature around the ear of a rabbit that the amount of reaction, when the constriction is relieved, varies directly with the tightness with which the ligature has been applied, and with the period of constriction. When applied loosely and only for a short time, the restoration of circulation is followed merely by a transient hyperemia, but as the complete- ness and duration of the obstruction are increased, the inflamma- tion becomes more and more intense, and even gangrene may ensue. Similar results follow the relief of strangulated hernia. In the less severe cases the intestine merely becomes temporarily congested, but in the more acute forms the paralysis of the gut may persist, whilst inflammation, possibly running on to gangrene, may be produced, either in the strangulated portion or in that immediately above, and thus, although the operation has been skilfully performed, the patient may succumb. The Clinical History of a case of strangulation is usually so characteristic that there can be but little uncertainty as to the diagnosis. The general symptoms are similar to those described at p. ioio, as occurring in all cases of acute intestinal obstruction. The patient during some sudden effort notices a severe pain, HERNIA 999 localized at first to one of the hernial regions, or referred to the umbilicus ; this is accompanied by the usual evidences of shock — i.e., he feels faint, the pulse becomes slow and weak, the tem- perature falls, and the surface is covered by a cold, clammy sweat. This shock is often not very prolonged, and is associated with or quickly followed by vomiting, at first gastric, then bilious, and finally stercoraceous or faecal. As this continues, the pain increases in severity, and radiates over the whole of the abdomen, which becomes tense, tender, and tympanitic. Symptoms of exhaustion supervene, caused partly by the pain and vomiting, and partly by the inability to take food ; probably the absorption of toxic material from the intestine also assists in its production. Complete constipation is usually present but the patient may pass flatus or fasces from the lower part of the intestine. The onset of gangrene is generally accompanied by a sudden fall of temperature and a cessation of pain, whilst the pulse becomes weak, rapid, and intermittent, the surface is covered by a cold sweat, the countenance becomes shrunken and drawn (the so-called ' facies Hippocratica '), hiccough follows, and finally the patient dies, usually as a result of toxaemia due to the absorption of products developed either in the bowel wall or sac, or in consequence of acute generalized peritonitis. Locally, the onset of the symp- toms is associated with the formation of a tumour in one of the usual sites of a hernia, or if already the subject of this condition, the patient may notice that his rupture has suddenly become larger. The swelling is irreducible, tense, extremely tender and painful, and without impulse on coughing. It is hard and rounded if bowel is involved, softer and more doughy to the touch, if omentum. When gangrene ensues, the tension within the sac is reduced, pain and tenderness cease, whilst the skin over the tumour becomes dusky, inflamed, and cedematous ; finally, evidences of gangrene show themselves externally, the parts becoming dark in appearance, and soft and emphysematous to the touch. If the patient survive, the necrotic tissues separate, and an artificial anus is produced either naturally or through the inter- vention of the surgeon. Suppuration within the sac is uncommon. Occasionally, however, cases are met with in which the above described signs are considerably modified, and in one of our cases the patient complained of no inconvenience beyond slight pain, although incipient gangrene was present ; he walked into hospital saying that he never felt better in his life. The early symptoms arising from strangulation of a portion of the lumen of the intestine (Richters hernia) are sometimes less marked than when a complete loop is constricted, but the later phenomena are always very severe. It is usually of the femoral variety, and the ileum is most frequently involved. If less than half the circumference of the bowel is constricted, the obstruction is not always complete at first, flatus and faeces being sometimes A MANUAL OF SURGERY passed ; but where more than half the circumference of the bowel is engaged, complete obstruction from kinking or paralysis of the gut ensues. The vomiting is less marked than in other cases, and is not so commonly faeculent. The tumour produced is small in size, but tense and tender. The prognosis in these cases is always grave, partly from the difficulty experienced in diagnosis, partly from the tightness of the constriction ; death usually results from perforative peritonitis, which is occasionally due to wounding of the gut by the hernia knife. The mortality in these cases is calculated at 62 per cent., which is in marked contrast with that of about 35 per cent., which is usually said to be characteristic of strangulated hernia. Our mortality for all cases of strangulated hernia, admitted to King's College Hospital during the years 1892 to 1897, only amounted to 16*6 per cent. The occurrence of strangulation in a pure epiplocele is very rare ; the symptoms are vague in character, and the diagnosis is often difficult. The presence of a soft, doughy, tender swelling in any of the hernial regions, combined with pain, bilious vomiting, and possibly constipation, is always a significant feature. So long as no kinking of the bowel is caused thereby, the symptoms may remain indefinite, the vomiting never becoming faecal ; but as time goes on, arrest of peristalsis may lead to true obstruction, or even general peritonitis. As already mentioned, strangulated omentum does not per se become offensive ; but occasionally a neighbouring coil of intestine may be dragged upon, and its circu- lation disturbed sufficiently to enable the Bac. coli to escape, and then it may find its way into the sac, and develop therein its characteristic odour without any serious lesion of the intestine or peritoneum being conjoined. The Treatment of a strangulated hernia consists in reducing the contents by taxis, or by operation. Taxis is the term employed for the manipulation by means of which a hernia is reduced. In cases of strangulation, it must be used with gentleness and great care, since the involved portion of intestine is congested and easily torn. The patient is laid on a couch with the head supported, and the thighs slightly flexed, so as to relax the abdominal muscles. The fundus of the tumour is then grasped with one hand, and steady pressure employed, having for its object the emptying of the congested bloodvessels, and consequently a diminution in the size of the hernia ; the fingers of the other hand manipulate the neck of the sac, in order that the part which has most recently been protruded may be first returned. The direction in which taxis is made varies in different cases. In inguinal hernia, it should be directed upwards, outwards, and backwards. In a femoral hernia which has ex- tended beyond the saphenous opening, taxis is first employed downwards and inwards in order to make the gut re-enter the crural canal, and then finally backwards and upwards, the HERNIA 1001 margins of the saphenous opening being relaxed by flexing and slightly inverting the thigh. In umbilical hernia, the pressure is mainly directed backwards. Whilst admitting the prima facie desirability of treating a strangulated hernia by taxis (since the patient's general condition is not such as to render any operation free from risk), it must not be forgotten that injudicious taxis may do more harm than even an unnecessary operation. The wall of the gut may be bruised or even ruptured, haemorrhage into the sac may occur, and even if successful one never knows the condition of the bowel that has been reduced. The greatest caution is therefore needed in select- ing cases to treat by this means. If the strangulation has lasted for more than twenty-four hours, if the swelling is very tense and tender, if faecal vomiting is present and the face becoming drawn and pinched, a very perfunctory attempt at taxis should be made. But if the swelling is free from tenderness and not very tense, if the vomit consists merely of unpleasant-smelling bilious fluid, and is not constant, and if the general condition is not really one of gravity, it may be justifiable to prolong one's efforts at taxis for ten or fifteen minutes, but even then the pressure must be con- tinuous and steady, not intermittent and jerky. A final attempt may always be made before operation when the patient is anaes- thetized. In some of the slighter conditions of strangulation, and especially if the patient has had similar attacks before which have been relieved without operation, reposition may be assisted by applying fomentations for half an hour, followed by the use of an icebag, reduction sometimes taking place spontaneously or being brought about by taxis. The heat relaxes the tissues around the neck of the sac, and the effect of the cold is not only to constrict these tissues, but also to induce contraction of the intestinal bloodvessels and muscles. Persistence of Symptoms after apparently Successful Taxis. — It occasionally happens that although the surgeon may have appar- ently reduced the hernia satisfactorily, the symptoms of strangula- tion, viz., pain, vomiting, and constipation, persist. Such may be due to a variety of conditions, and considerable judgment is needed in coming to a correct decision in any particular case, (i.) The vomiting may possibly be due to the anaesthetic, but then does not usually last for any length of time, and soon loses its faecal character, (ii.) The gut remains paralyzed from the effect of the constriction ; inflammation may then supervene, involving either the released coil of gut or the portions above or below it, and perhaps running on to ulceration, perforation, and death from peritonitis or toxaemia, (iii.) The rupture reduced may not be the one which has given rise to the symptoms, an internal hernia, or one in some other region, co-existing, (iv.) The strangulation may have been caused, not by the neck of the sac, but by a slit in A MANUAL OF SURGERY the omentum contained in the sac. Reduction in such a case would not relieve the symptoms, the whole mass being returned into the abdomen, (v.) The hernial sac may have a diverticulum or pocket communicating with it at its upper end (intraparietal interstitial hernia), or it may be shaped like an hour-glass. It is possible to reduce the intestine from the lower portion of this so-called hernia en bissac into the upper pocket, and then of course the symptoms persist, (vi.) Reduction en bloc or en masse may occur, but only when considerable force is employed ; in this the sac and its contents are together reduced from their superficial position to the deep aspect of the abdominal parietes, the hernia then lying between the muscular planes or in the subserous areolar tissue, and the constriction remaining. The hernia gradually disappears, but without the characteristic gurgle. In such a case the sac sometimes gives way, the intestine and the portion of the neck which compresses it being pushed upwards. When occurring in the inguinal region it is recognised by the persistence of symptoms, and by the fact that a finger inserted into the canal, which is unduly patent, detects a tense rounded swelling at its upper end. It also occurs, but less commonly, in the femoral region, and in either variety the hernia may slip down again a short time after its apparent reduction. In any case where, after an apparently successful taxis, the symptoms of strangulation are still present, a most careful investigation is needed in order to ascertain, if possible, the cause. Thus, the character and frequency of the vomiting must be con- sidered, since, when due to anaesthetics, it usually loses its faecal character, and is less severe. If the vomiting is associated with a certain amount of local pain, and possibly with some blood- stained diarrhoea or the passage of mucus, the probability is that the coil of gut has been in reality reduced, but has subsequently become inflamed. Apart from such indications the affected region must be thoroughly explored with the finger, so as to ascertain whether any tumour can be felt at the upper or deeper end, as occurs in reduction en masse. Should this throw no light upon the case, the other hernial apertures must each in turn be examined, and finally an incision is made over the supposed site of strangu- lation, and an exhaustive search made for the sac. If no help is thus obtained, the abdomen must be opened, and an internal strangulation sought for. In the inguinal region, all that is needed is to prolong the first incision upwards and outwards ; in a femoral hernia, it is perhaps wiser to make a separate lapar- otomy wound in the middle line, so as to avoid the division of Poupart's ligament ; whilst in the umbilical variety, the require- ments of the case are met by simply increasing the size of the communication between the sac and the abdominal cavity. The Operative Treatment of strangulated hernia should always be undertaken at as early a date as possible, when once it is certain HERNIA 1003 that the bowel is constricted, and taxis has failed. Nothing can be gained by waiting, whilst even the delay of an hour may make it doubtful whether the result will be successful or not. There is always sufficient time to permit of efficient purification of the parts, whilst it may be desirable to empty the lower bowel by an enema, and if there is much vomiting to wash out the stomach. The administration of an anaesthetic needs care, and in the worst cases local anaesthesia must be depended on (see p. 1015). A suitable incision is then made down to the sac, which should be recognised by its tense and rounded outline. It is isolated as far as possible from surrounding structures, and then carefully opened. There is usually no risk of injuring the bowel, on account of the fluid poured out into the sac ; but if no effusion is present, or if the gut is adherent to the anterior wall, it is more likely to be injured. Having given exit to the fluid from the sac and noted its characters, the surgeon carefully examines the bowel or omentum. The cause of strangulation is then looked for and divided by a special hernia knife, which practically consists of a curved blunt-ended bistoury, the cutting blade being limited to an extent of about f inch from the blunt end. If such is not to hand, an ordinary curved bistoury will suffice. The index-finger is employed to repress and guard the intestine, and acts better than a director, since intestine is likely to curl up on either side of the instrument, and may thus be injured. The knife is then slipped on the flat under the constriction, and turned so as to divide it ; it is better to slightly nick it in two or three places than to incise it by one deep cut, as is often recommended. The gut is drawn down into the wound, and its condition at the site of strangulation carefully examined. The omentum, if small in amount and recently prolapsed, may be reduced, but it is better practice to remove any congested portion, or that which has evidently been in the sac for some time. The method of its removal has been already described (p. 986). According to the condition of the intestine, the further steps of the operation are modified as follows : 1. If the gut, though congested, shows no sign of gangrene or perforation, it may be safely reduced. This is not always a matter of ease, owing to the fact that the effusion into its walls has made it stiff and firm. Prolonged and steady pressure with the fingers will, however, sufficiently remove the exudation to permit of its reposition into the abdomen. All manipulation directed to the intestine must, of course, be of the gentlest nature, since its congested state makes it more friable than usual. 2. If the gut has been tightly strangled and gangrene is threaten- ing, it may be advisable to resect it at once, the incisions being made well above and below the sites of constriction ; the divided ends are united by one of the plans detailed at p. 932. If, how- ever, the bowel is in a doubtful condition, but recovery thought io.to r ' j p '-' j# Fig. 380 — Uric Aciu Crystals. Fig. 381. — Urate of Ammonium in Amorphous Granules and Hedgehog-shaped Bodies. present, the patient is often said to be suffering from Lithiasis or Lithsemia. Should the individual be incapable of eliminating the material thus formed, an attack of gout or rheumatism is likely to supervene, whilst it must always be borne in mind that the formation of a uric acid calculus is merely a manifestation of the same diathesis, which needs careful treatment after the removal of the stone, if a recurrence of this painful affection is to be prevented. The Treatment of lithsemia or lithiasis consists mainly in atten- tion to the personal hygiene. The patient's diet is regulated, all sweets, pastry, and alcoholic stimulants (with the exception, perhaps, of a little whisky well diluted with lithia or potash water) being avoided. Regular habits are enforced, and plenty of outdoor exercise recommended. The hepatic secretion is stimulated, and the bowels regulated by the administration of saline purgatives, especially natural mineral waters, e.g., Fried- richshall, Carlsbad, or Hunyadi Janos, whilst an occasional dose of blue pill or podophyllin is advisable. Lithia salts and piperazine have also been employed with advantage. Oxalate of lime usually occurs in the urine of dyspeptic and hypochondriacal patients, who are pale, nervous, and irritable. BLADDER AND PROSTATE 1089 It is supposed to arise from the incomplete oxidation of carbo- hydrate foods. The urine is of low specific gravity, pale and abundant in quantity, and slightly acid in reaction ; an excess of mucus is usually present, causing the crystals to adhere to any irregularities in a test glass. On microscopic examination they are found to be regular octahedra, or in the shape of dumb-bells (Fig. 382). The tve.atment of oxaluria consists in regulation of Fig 382. — Oxalate of Lime in Octahedral Crystals and Dumb-bell- shaped Masses. the diet, which must be light and nourishing, all heavy food being avoided, as also rhubarb, which contains large quantities of oxalates, and the patient is directed to drink only boiled or dis- tilled water. Tonics, such as mineral acids, iron, and quinine, may be ordered, but the best treatment consists in change of air and removal, if possible, from causes of anxiety and worry. Phosphatic deposits in the urine occur in three forms : (i.) The triple phosphate, or ammonio-magnesic, is found in alkaline or 4^ Fig. 383. — Crystals of Triple Phosphate in Urine. decomposing urine, and is always vesical in origin. It exists in the form of hexagonal prisms, three of the sides, however, being very narrow ; the ends also are bevelled off, so that the appear- ance of a ' knife-rest ' is produced (Fig. 383). (ii.) The amorphous phosphate of lime is exceedingly common, forming the main mass of any phosphatic sediment. It is always present in chronic cystitis, and is not unfrequently met with a few hours after a meal, constituting what is known as the 'alkaline tide.' This condition is often observed about twelve o'clock in the morning, especially if an alkaline saline purgative has been taken before breakfast. The phosphatic material is voided at the end of the act of micturition, and may give rise to considerable anxiety 69 logo A MANUAL OF SURGERY on the part of the patient, who mistakes it for seminal fluid, (iii.) The most usual condition in which phosphates are met with in urine is a mixture of the two varieties described above. Which- ever form is present, the deposit becomes more evident on boiling, disappearing, however, on the addition of a few drops of acid. The treatment of phosphaturia is always directed to the vesical condition, except in those unusual cases where it is due to some constitutional error. 2. Hematuria, or the admixture of blood with the urine, is best described according to the source from which the blood is derived. (a) Renal hematuria results from acute inflammation, conges- tion, calculus, tumours, or injuries of the kidney. The urine is sometimes deeply coloured with the blood, and may be as dark as porter. Blood casts of the renal tubules are often observed, and even long sinuous clots, corresponding to the shape of the ureter. (b) Vesical haematuria is due to injury, calculus, tumours, ulcera- tion, simple congestion of the bladder with varicosity of the vesical veins, or the presence of the Bilharzia luematobia. The blood is intimately mixed with the urine, but is more abundant at the end of micturition, and clots are often present. The Bilharzia is a parasite which inhabits some of the rivers and pools of South Africa. It is taken into the system by the mouth, and may develop either in the urinary track, or sometimes in the lower bowel (p. 1027). The adult worms are found in the body inhabiting the radicals of the portal and vesical veins, and discharge their ova through the mucous membrane of the bowel or bladder, giving rise to haemorrhage. By an extension to the kidney, pyonephrosis may be induced. No specific treatment has at present been discovered, but in most cases the disease after a time disappears spontaneously. (c) Prostatic haematuria may be caused by congestion, calculus, ulceration, or malignant disease ; the blood passes back into the bladder, and hence the phenomena simulate the vesical condition. Examination of the prostate from the rectum may, however, give a clue to the source of the mischief. (d) Urethral haematuria arises from acute gonorrhoea, laceration, or instrumentation. The blood often flows from the urethra in- dependently of micturition, whilst the first few drops of the stream are also coloured. (e) Haematuria is occasionally of constitutional origin, arising from purpura, scurvy, or haemophilia ; other evidences of these diseases will be observed, and render the diagnosis evident. Microscopical examination of the urine should always be made to ascertain whether or not blood corpuscles are present, since the condition may be simulated by that known as ' paroxysmal haemoglobinuria,' in which corpuscles are absent. The latter BLADDER AND PROSTATE 109 1 condition is supposed to be due to vaso-motor spasm of the renal vessels, and is not uncommonly associated with Raynaud's disease. The only certain test for the presence of blood is by spectrum analysis ; but that most usually relied on consists in mixing together equal parts of tincture of guaiacum and ozonic ether. The suspected urine is subsequently added, and sinks to the bottom of the test-glass ; a copious precipitate forms at the line of junction of the two fluids, which on standing becomes a bright blue colour if blood is present. The investigation of a case of haematuria in order to ascertain its origin should be conducted in the following way : (a) The history of the patient and of his urinary trouble should be taken. (b) The character of the urine should be investigated, noting its colour, and whether or not the blood is intimately mixed with it. (c) The relation of the passage of the blood to the act of micturi- tion should be noted by making the patient pass the first and last portions of the urine into separate vessels from that in which he passes the bulk ; if the urine in all three vessels is equally dis- coloured, the haemorrhage usually comes from the kidneys ; if most of the blood is in the first vessel, it comes from the urethra or prostate, whilst if the bulk of it is contained in the last vessel, it is probably derived from the bladder, (d) Microscopical ex- amination of the urine may lead to the discovery of shreds of tumour, epithelial cells, or blood-casts, which could be alone derived from some special part of the urinary track. By these means the source of the haemorrhage, whether from kidney, bladder, prostate, or urethra, may be detected, and an opinion formed as to the nature of the disease. 3. Pyuria is the term applied to the admixture of pus or muco- pus with the urine. It always results from inflammatory affec- tions of the mucous membrane lining the urinary passages, and may be renal, vesical, prostatic, or urethral in origin ; the methods of investigation, in order to ascertain its exact source, are the same as for haematuria. Pus in urine is mainly recognised by the microscope, whilst on the addition of liquor potassae it becomes ropy. 4. Chyluria arises from distension or rupture of the lymphatic vessels in the vesical mucous membrane, and is usually due to the presence of the Filavia sanguinis hominis (p. 316). The urine is milky in colour, and on microscopical examination this is found to be due to the presence of an emulsion of fat. 5. Albuminuria, or the escape of some of the albuminous contents of the blood with the urine, is a condition of such frequent occurrence, and so important in its results, that the precaution should always be adopted of testing the urine of every patient before attempting any operative proceedings ; and this is the more essential because it is well known that this condition often exists quite unexpectedly and entirely apart from symptoms. 1092 A MANUAL OF SURGERY Tests. — Many different methods have been adopted for detect- ing the presence of albuminuria. The following are, however, the chief: (i) On simply boiling the urine a milky white deposit forms, similar to that which is caused by an excess of phosphates ; the latter, however, disappears entirely on the addition of a single drop of dilute acetic acid, whilst the former persists. (2) Nitric acid gives a white cloud or light-brown flocculent precipitate. The urine should first be boiled, and the acid added, but not in excess, as the deposit may be re-dissolved. A more delicate test consists in pouring the cold urine into a test-tube, and carefully adding the acid, so as to form a stratum below the urine ; at the line of junction of the two, a white film is formed, if albumen is present. (3) With picric acid a yellowish-white precipitate is thrown down, increased by boiling. If the urine is neutral or alkaline, it must first be rendered slightly acid by the addition of a few drops of acetic acid. When once the existence of albumen in the urine has been ascertained, its source and its significance must be investigated. A careful microscopical examination of the sediment is made, so as to determine whether casts or pus cells are present. The con- dition of the peripheral bloodvessels in the limbs and the character of the pulse should be noted, as also the previous history of the patient. Albuminuria arises from a variety of sources, and its significance necessarily turns on the origin of the affection. (1) When it occurs in the course of some disease involving long-standing sup- puration, such as septic affections of bones or joints, it is probably due to lardaceous change in the kidneys. If the urine is of low specific gravity and light in colour, and with but few casts, only an early stage of the condition is present, and conservative measures directed to the treatment of the primary lesion will probably suffice ; if, however, the urine is scanty and of high specific gravity with much albumen and many casts, the affection has probably progressed some way, and radical treatment, such as amputation, should be undertaken to save the patient's life. The surgeon must be careful to prevent any undue absorption of carbolic acid in the operation, as thereby acute nephritis may be lighted up, and even a fatal issue determined. (2) Albu- minuria may be intermittent, and is then due to some temporary functional disturbance ; this can only be ascertained by testing the urine from time to time. In such cases operation is not contra-indicated, the albumen usually disappearing with rest and careful diet. (3) When caused by chronic Bright's disease, the concurrent phenomena of that affection will also be present in the shape of thickened arteries and high pulse tension, whilst possibly a certain amount of anasarca may be noted, or the history of such at an earlier date. If there is but little albumen, and a fair amount of urea is being passed, it is possible by rest and suitable BLADDER AND PROSTATE 1093 diet so to diminish it as to warrant the performance of slight operations ; but where the condition is at all advanced, all operations de complaisance are absolutely contra-indicated, and only the chief surgical emergencies should be knowingly dealt with, viz., haemorrhage, asphyxia, intestinal obstruction or strangula- tion and retention of urine. In cases of severe injuries, amputa- tion is generally indicated under circumstances where in a healthy individual conservative measures would be adopted. Operation for malignant disease may be undertaken at the express wish of the patient, if the increased risks associated with it have been ex- plained to him. The importance of not operating on these patients depends on the facts that they tolerate an anaesthetic badly, that the tissues are in a condition of lowered vitality, and hence the process of repair is hindered, septic inflammations and erysipelas are very prone to develop, whilst secondary haemorrhage is likely to follow, owing to the high pulse tension. Again, boils and carbuncles are very common in these patients, and where such conditions are met with, and especially if they recur, the urine should always be examined. (4) Albuminuria may arise by extension of inflammation to the kidneys from surgical affections of the lower urinary organs, and a fatal result from shock or sup- pression of urine may be induced by operations under these con- ditions. (5) It is occasionally the result of cardiac disease, owing to valvular incompetence and regurgitation into the systemic veins, and it is then advisable to delay all operative measures until digitalis has been administered in sufficient doses to alleviate the urgent symptoms. 6. Diabetes. — The presence of sugar in the urine is also a matter of the greatest importance from a surgical standpoint, and its existence or not should always be carefully ascertained. The chief tests employed are as follows : (1) Equal parts of liquor potassae and solution of copper sulphate are boiled together, and then a few drops of the suspected urine added ; if sugar is present, a yellowish-red precipitate forms by the reduction of the cupric salt to cuprous oxide. (2) The same result follows the use of Fehling's solution. It is better to keep the copper solution separate from the potash ; equal parts of them are boiled together, and a few drops of the urine added ; if sugar is present, a red deposit occurs. (3) Picric acid and liquor potassae are mixed and boiled, and the urine added ; the presence of sugar is indicated by the solution turning to a dark, blackish-red colour. The admixture of 2 grains of sugar to the ounce is sufficient to determine this discoloration to such an extent as to render the fluid quite opaque. The effect of diabetes is very similar to that of albuminuria, in that it leads to diminished vitality of the tissues, and consequently predisposes to the occurrence of sepsis, and of such infective inflammations as boils and carbuncles. Peripheral neuritis and ICQ4 A MANUAL OF SURGERY sclerosis of the smaller vessels are also induced by this disease in the later stages, and hence gangrene of the extremities is likely to occur, especially in chronic cases and in elderly people. The essential cause of trouble, however, is sepsis, and hence if the most rigid aseptic precautions are taken there is no reason why operative proceedings should not be undertaken in conditions of danger and urgency. Thus several cases have been reported lately in which such serious proceedings as total removal of the breast and axillary contents for scirrhus, or appendicectomy, have been safely undertaken in confirmed diabetics. Stone in the Bladder. Varieties. — A vesical calculus may be formed of almost any of the urinary deposits commonly met with, and each has its own special characteristics. (a) The uric add calculus (Fig. 384) is usually an oval, flattened J£