COLUMBIA LIBRARIES OFFSITE HEALTH SCIENCES STANDARD HX641 28385 RC74 .F27 1914 Blood-pressure prime RECAP CoUege of ^tesficiang anb ^urgeoniS mhvaxv Digitized by tine Internet Arciiive in 2010 witii funding from Open Knowledge Commons http://www.archive.org/details/bloodpressurepriOOfaug RCT4 rzT College of $t)pfiitian£j anb burgeons; Hibrarp BLOOD -PRESSURE PRIMER THE SPHYGMOMANOMETER AND ITS PRACTICAL APPLICATION BY FRANCIS ASHLEY FAUGHT, M.D. LATE DIRECTOR OF THE LABORATORY OF CLINICAL MEDICINE, MEDICO- CHIRURGICAL COLLEGE AND HOSPITAL. INSTRUCTOR IN MEDICINE, MEDICO-CHIRURGICAL COLLEGE. AUTHOR OF ESSENTIALS OF LABORATORY DIAGNOSIS. BLOOD PRESSURE FROM A PRACTICAL STANDPOINT, ETC., ETC. Containing One Full-page Plate and Numerous Explanatory Diagrams in the Text COPYRIGHT, 1914 B Y FRANCIS Ashley Faught PUBLISHED BY G. P. PILLING & SON CO. PHILADELPHIA 1914 Pilling-Faught Pocket Sphygmomanometer in Use. C O N T E N 1 S CHAPTER I. i'A(;k The Value of the Sphygmomanometer . 3 The Diastolic Test. CHAPTER H. The Circulation 15 CHAPTER 111. The Sphygmomanometer .... 21 CHAPTER IV. Normal Blood-Pressure and its Variations 53 CHAPTER V. Practical Application of Clinical Data . 65 CHAPTER VI. Pregnancy, Toxemia and Eclampsia . . 91 CHAPTER VII. Blood-Pressure in Surgery and Anesthesia 95 Dental Anesthesia. CPIAPTER VIII. Therapeutics Indicated by Blood-Pressure Changes Ill CHAPTER IX. Blood-Pressure in Life Insurance . . 115 CHAPTER I. THE VALUE OF THE SPHYGMOMANOMETER, The Importance of the Blood-Pressure Test . 4 In General Diagnosis . . . . 5 In Insurance Examinations . . . 6 Importance of Diastolic Reading .... 6 Accuracy of the Auscultatory Method . 7 The Pulse Pressure ..... 8 Normal Relations in Complete Blood-Pressure Tests 9 Graphic Formulas for : . . . . 9 Estimation of Heart Work . . .10 Estimation of Velocity .... 10 In Arterial Disease . . . . . 11 In Heart Disease 12 Example of Case . . . . . 12 Infectious Diseases ..... 13 CHAPTER I. THE VALUE OF THE SPHYGMOMANOMETER AND THE IMPORTANCE OF THE BLOOD- PRESSURE TEST. "The value of the blood-pressure test is acknowl- edged by every up-to-date physician. Like the clinical thermometer, the stethoscope and other instruments of precision, the sphygmomanometer is an aid to accuracy in diagnosis, and any instru- ment that will enable the physician or surgeon to do better work is not to be set aside or passed by without careful investigation." (J. F. Prendergast, Chicago Medical Record, March, 1913.) The best single guide to the practical value of a new method is to determine whether it is receiv- ing increasing endorsement from qualified authori- ties. At the present time all well-equipped hospi- tals have sphygmomanometers in daily use in the wards. It is seen in Children's Wards as a guide to prognosis and treatment ; in Obstetrical Wards in diagnosis and treatment of toxemias. The oculist and aurist are finding blood-pressure measurement of increasing value, and tuberculosis sanatoria are modifying their prognosis and treat- ment according to the indications of this sign. J. B. McAllister, in "The Medical Council" for July, 1912, states that the Medical Director of a Importance of Test. large insurance company published statistics which show that in 1247 risks of all ages in which there was a blood-pressure of 150 mm. Hg. or over, the mortality was 2^ times greater than the general average mortality of the company covering the same period. Richard C. Cabot says: "If I were allowed to have only two instruments of precision for my aid in physical diagnosis, they would be the stetho- scope and sphygmomanometer. I have been saved from wrong diagnosis and put on the track of right ones more often by this machine than anything else I know of except the stethoscope. I regard this measurement of the blood-pressure as the most important of all the resources that have been added to our armamentarium as physicians in the last 15 years. I could talk all afternoon on the subject of blood-pressure, but I will confine myself to saying that it puts me right most often in relation to car- diac and renal diseases. Patients, the examination of whose hearts did not show anything certainly characteristic of disease, have often been shown to me to be diseased, or proved later to be diseased, by the high blood-pressure registered by the ma- chine, pressure which my fingers are not always able to detect. In feeling the pulse I no longer trust my fingers to be sure of a high tension pulse; I used to, but I have convinced myself that I can- not do it. On the other side there are many irregu- lar hearts, which you finally conclude to be merely functional in origin, having no immediate signifi- cance; because the blood-pressure is normal. An irregular heart plus a high blood-pressure is serious. Importance of Test. The very same irregular heart, with low pressure, may be of no great significance. "Then call your attention to the early diagnosis of kidney lesions. I see a good many cases of renal disease entirely free from albumin or from casts, but with high blood-pressure, which are shown, post-mortem, to be renal disease. These cases could not have been suspected to be renal diseases ex- cept by blood-pressure. In other words, I regard the blood-pressure measurement as of more im- portance than the examination of the urine in chronic kidney trouble. Examination of a specimen has again and again led me astray; the measure- ment of blood-pressure almost never." Physicians who can practice successfully without materials for a urinalysis or without a blood-pressure instrument will find it difficult to hold insurance appointments ; furthermore, patients are learning that an examiner who is preferred by an old insur- ance company is the safest man to trust as a physi- cian. A hundred examiners could give us a reliable blood-pressure reading where only one could detect cardiac hypertrophy or an accentuated aortic second or a minute trace of albumin in chronic interstitial nephritis. The foregoing has all been said of the simple estimation of the systolic blood-pressure, as made by the modern sphygmomanometer, of which the Faught instruments are typical. It must not be forgotten, however, that recent developments in the study of blood-pressure have emphasized the grow- ing importance of the diastolic pressure. In this The Diastolic Test. connection I quote again from the article of Dr. Prendergast above referred to, in which he says : "Some of our cHnicians place little value on dias- tolic pressure for the simple reason that they can- not interpret its findings. This is a great mistake, as the systolic pressure is only one side of the picture, and we cannot explain the pulse pressure or judge of the systolic output or the work the heart is doing without knowing the diastolic pres- sure. Now I contend that it is of great importance to know whether under certain conditions the pulse pressure, if 20, 40, 60 or even 100. In the first case it would mean a rather feeble drive to. the heart, with a small systolic output. In the latter the heart is working too hard in overcoming periph- eral resistance, or loss of elasticity in the vessel wall, and is calling on its reserve capacity; as long as it is compensated we have a good case, but once our reserve capacity is overcome and decompensa- tion sets in, look out for trouble. The narrow pulse pressure is found in wasting diseases, like tuber- culosis, in shock, after profuse hemorrhage, in chlo- rosis, etc., and always accompanies a failing heart." Diastolic Test. Until the practical demonstration of the accuracy of the Auscultatory or Auditory method of reading blood-pressure, little valuable work was recorded in connection with this test, for the reason that so much difficulty was experienced in making this part of the test, that few routinely employed it, and those who made this effort were not repaid for their trouble, as the figures obtained were so The Diastolic Test. uncertain and unreliable that no dependence could be placed on them. The studies of Warficld and others have shown the accuracy of this method, which can be relied upon to give an accurate reading under practically all circumstances, irrespective of the age of the patient, the size of the vessel, or the size of the arm to which the cuff is attached. In' order to analyze the results of a complete blood- pressure observation, it is essential to review the fac- tors controlling blood-pressure. From the clinical standpoint at least, we may consider the blood-pressure depending mainly upon the contractile powers of the heart, which pumps the blood forward, on the one hand, and the calibre of the blood-vessel walls, which offer peripheral resistance to its flow, on the other. And also that peripheral resistance itself depends largely on the tonicity of the walls of the blood-vessels which comprise the general capillary system. Patho- logically, we must recognize that changes in blood- pressure are largely due to departures from the normal force of the heart and to alterations in the elasticity and tonicity of the general arterial tree. It will thus be seen that the systolic pressure will approximate closely the actual pressure developed by the heart within the heart itself at the moment of systole, while the mini- mal or diastolic pressure wall be the measurement of the peripheral resistance, w^hich is able to maintain to a varying degree the arterial pressure, while the heart is dilating, plus the factor of elasticity, wdiich also aids in maintaining the continued pressure in the vessel during diastole. In the pulse pressure, then, we must have the The Pulse Pressure, measurement of the amount of force exerted by the heart in maintaining blood-pressure over and above that normally maintained by peripheral resistance, i. e., the pulse-pressure gives a figure which roughly measures the pumping capacity of the heart. These facts show clearly the importance of always making a diastolic reading, so that the pulse pressure may be computed. Gibson, due to his ingenuity and experience, has de- vised formulae whereby we are able to more or less carefully estimate not only the capacity of the heart for work, but also, in a rough way, its output. Gibson has demonstrated that there exist certain definite relations between these several factors and has combined them into a working formula. Briefly, these propositions are as follows: Under normal conditions there is a definite relation- ship between systolic and diastolic pressure and also a relation between systolic and pulse-pressure. The re- lation of the diastolic pressure to the systolic pressure obtained by auscultation is about as two is to three and that of pulse-pressure to the systolic pressure as one is to three. For example, if the systolic pressure is 140, the normal diastolic will be approximately 95, while the pulse-pressure should approximate 45 or 50. If we bear in mind the fundamental fact that all blood-pressure readings vary normally within certain well-known limits, it will readily be seen that these relations are at best only approximate, which, how- ever, does not materially detract from their clinical value. Actually employed, they have been found to be most valuable guides in separating the normal from the pathological and in estimating the degree of over-load in cardio-renal cases. Gibson's Formula. Following tlie same reasoning, if the pulse-pressure roughly estimates the systolic output, it follows that this is also an important factor in the velocity of the blood-stream, which for i)hysical reasons must bear a definite relation to the volume output of the heart and to the caliber of the conduits — the arteries — so that, if other factors remain the same, it is not a difficult mat- ter to estimate both the velocity and also the work of the heart while operating under either normal or ab- normal conditions. The above propositions can, according to Gibson, be arranged graphically as follows : For example, take a case presenting these figures : S. P. 130, D. P. 85, P. P. 45, P. R. 70; then— P. P. (45) X P. R. (70) = Velocity (3100), and S. P. (130) X P. R. (70) = Work (9100). We may carry our calculations further and state that the velocity and the work, as estimated by the above formula, also bear a definite normal relation which is dependent entirely upon the normal relation of pulse-pressure to systolic pressure (which can only be determined by measuring the diastolic pressure). This velocity-work relation is as one is to three, and is not dependent upon the pulse rate. For as long as the relation of systolic to diastolic pressures remain normal (they may of course be different in every case, without changing their normal relation), the velocity- work ratio will be normal, no matter what the pulse rate. If we have a more rapid pulse, with unchanged pressure, we undoubtedly increase the total expendi- ture of heart energy, both for velocity and work; on the other hand, it is possible to conceive of a decreased pulse rate with a rising general pressure, w-hich 10 Gibson's Formula. would not only allow the velocity-work ratio to remain unchanged, but which need not necessarily add ma- terially to the work of the heart. As a matter of fact, this is precisely what does occur within certain limits under normal conditions. To show this, it is only necessary to note the effect of change in posture upon blood-pressure and pulse rate, as discussed on page 00. The normal arterial tree will withstand a continual variation in pressure of from 35 to 50 mm. without undergoing pathologic change. Under those condi- tions in which we have a pulse-pressure of more than this, it is evident that the blood-vessels are required to withstand undue stress ; and so if we here subtract the normal pulse-pressure from the pathologic, we have relatively the measurement of the increased work- ing of the heart. Now if this difference is multiplied in turn by the pulse rate per minute, then by 60 and by 24, it is very easy to see the relatively tremendous ex- cess of work and energy required of the heart in every 24 hours in order to maintain circulation and nourish the tissues. This w^ould seem to be the true explana- tion of heart hypertrophy, arterial change and ultimate cardiac dilatation with failing circulation. Lauder Brunton says "The diastolic pressure is a factor of great importance, because by its amount and by the dift'erence between it and the systolic pres- sure we obtain valuable data in regard to the strength of the heart and the condition of the arterioles." V. Pachon w^as among the first to express the belief that the normal systolic pressure was not only of un- certain value in the study of many pathologic cases, but that its variation within wide limits and at short intervals for any individual, even slight physiologic TiiK Diastolic Pkkssuuk causes, might be actually misleading, as under the fol- lowing conditions: In decomi)ensaled cardio-renal cases where the maximal pressure may be normal, it is only by determining the abnormal elevation of the diastolic pressure and consequent reduction in ])ulse- pressure that we are able to clinically confirm the cir- culatory fault. The minimuni pressure represents the true constant load borne by the arterial tree and the resistance which the heart is obliged to overcome before its contents can be expelled. Both data of fundamental importance from the clinical pathologic standpoint. It has been found also that the diastolic pressure is a far more constant factor in normal individuals than the systolic, that it is practically the same for all parts of the arterial tree, while the maximal pressure drops progressively from aorta to periphery. W. R. Sheldon, Medical Record, December 31st, 1910, adds the following to our already rapidly in- creasing information : The lessened elasticity of the arteries which is found in many conditions contributes to an abnormal relation between the diastolic and systolic pressure, so that in long-continued high blood-pressure, due to les- sened elasticity in the artery, there is a failure of the diastolic pressure to maintain its normal relation. The pulse-pressure is increased and we can, by the formula already described, estimate the amount of extra work which is demanded by the high pressure incident to arterial rigidity. From these we can draw the follow- ing corollary, which is, that increased strain on the heart is to a large degree measured by the amount of diastolic failure, i. e., the larger the pulse-pressure in 12 The Diastolic Pressure. relation to the diastolic pressure, the greater will be the cardiac strain, which finally fails to respond to the increased demands and enters into a condition of decompensation. So that we may look for signs of poor circulation when there is a high systolic pressure and a diastolic pressure that is relatively low; and conversely, if measures directed toward removing the cause of this abnormal relation are successful, we may measure the amount of improvement by the elevation of diastolic pressure and consequent reduction of pulse-pressure, as is well shown in the case above de- scribed. These two formulas have been discussed at some length because of their fundamental importance and wide applicability. By means of these, it is a simple matter to compute the excessive work required of the normal heart under varying conditions of strain and load, and also in those pathologic conditions of the circulation accompanied by changes in the heart, blood- vessels and kidneys. Anyone who appreciates the value of the blood-pressure test will find these studies of great assistance in diagnosis, prognosis and treatment. The following case from actual practice shows the method of its employment and the information de- rived : Case of Chronic Myocarditis and Arteriosclerosis. Before treatment—S. P. 210, D. P. 100, P. P. 110, P. R. 104. S. P. (210) X P. R. (104)=\ Work (21840) _ . P. P. (110) X P. R. (104) —' ~ ^^^^^ ^ ^° ^• Velocity (11440) ) Effect of Treatment. 13 After two weeks' treatment— S. P. 195, D. P. 140, P. P. 55, P. R. 84. S. P. (195) X P. R. (84) =\ Work (14580) __ P. P. (55) X P. R. (84) = - ""^^'^ ^ ^° ^• Velocity (4620) ) Here, under proper methods of treatment, the work-velocity was greatly benefited, the actual work reduced one-third, so that while the heart was at first only able to maintain the needs of the case under serious strain, and accompanied by evident signs of cardiac distress. After two weeks the danger of acute failure of the circulation was overcome and the whole complexion of the case altered for the better. In pneumonia and most infectious diseases a falling blood-pressure with a narrowing pulse-pres- sure means great danger. A wide pulse-pressure is found in arteriosclerosis, with loss of elasticity in the blood-pressure and with increased peripheral resistance ; in chronic interstitial nephritis, and is very wide in aortic insufficiency, in fact, it is often pathognamonic of this condition. Dr. George Oliver says that of the two he has come to consider the diastolic pressure just as precise as the systolic and more valuable. CHAPTER II. THE CIRCULATION. Instruments for Study of Blood-Pressure Practical Sphygmomanometry Physiology of the Circulation Arterial Pressure Causes of Normal Pressure Terms and Definitions . The Pulse Blood-Pressure Systolic Blood-Pressure Diastolic Pressure Pulse Pressure or Range Mean Tension . Normal Tension Hypotension Hypertension Auscultatory Blood-Pressure 15 16 16 16 17 17 18 18 18 18 18 19 19 19 19 20 CHAPTER II. THE CIRCULATION. The application of instruments of precision for the study of conditions of the circulation marks an epoch in the history of medicine. The application of scien- tific instruments in clinical medicine has developed a large amount of valuable information concerning the relation of the heart, blood-vessels and kidneys, in both normal and pathologic conditions. We are now able, by means of easily applied tests, to gather accur- ately and quickly an enormous amount of detailed information which could have been found by no other means. This general increase in knowledge of special dis- eases has placed an added amount of responsibility upon the medical profession, for the public has so learned to appreciate the benefit to be derived from this broader knowledge, that patients now demand special methods of examination ?nd study, in every case, far greater than was ever dreamed of twenty years ago. Among the many scientific instruments now em- ployed in the study and practice of medicine, there is probably not one single instrument of greater use and of easier application than the sphygmomanometer. Its value has now become so fully established that it needs no argument to show^ an intelligent physician 15 16 Physiology of Circulation. that the sphygmomanometer is a most important part of his armamentarium. In taking up this discussion of blood-pressure apparatus and blood-pressure tests, it is only neces- sary to call attention to the fact that the normal circu- lation is a vital function necessary in the maintenance of health and that the cardio-vascular system is involved to a more or less degree in the great majority of diseased conditions. It is evident that the knowl- edge of the condition of the heart and circulation plays an important part, not only in diagnosis, but in prog- nosis and in treatment. In taking up the consideration of the subject of blood-pressure, a brief review of the physiology of the circulation is essential in order that departures from it may be recognized and that these changes may be given their proper value in the general symp- tom-complex. Roughly speaking, the heart and arteries may be likened to a force pump and series of elastic tubes, which supply every part of the body with nutrition, remove waste products and at the same time con- tribute to the size and density of the organs. The heart is a compound pump of intermittent action. From this springs the aorta, which rapidly ramifies from the heart to the periphery. The aorta receives blood from the heart in intermittent jets, and this would be transmitted to the periphery in the same intermittent manner were it not for the elasticity and other vital properties of the blood-vessel walls. The mechanism of the circulation is largely con- cerned in reducing this intermittent stream to the con- tinuous flow found in the organs and capillaries. It Causes of Normal Pressure. 17 is also concerned in maintaining^ the proper supply of blood to each part as the demand may arise for increased nutrition. In order to accomplish this func- tion, it is essential that the blood should be maintained under a certain degree of pressure. This is necessary to insure the proper distribution and to bring an in- creased supply to any particular region when de- manded. This relation is maintained by what is known as blood-pressure. Normal blood-pressure depends upon the normal correlation and interaction of certain variable factors : (1) The amount of blood pumped into the arterial system by the heart. (2) The resistance offered to the escape of blood toward the periphery through the smaller arteries and the capillaries. Of less import- ance are (3) the elasticity of the vessel walls, (4) the total quantity of blood in the body, and (5) viscosity. These factors are all capable of interaction in the most complicated manner. For example, if the arterial pressure is increased from any cause, the vagus nerve is stimulated, and the effect of its inhibitory action upon the heart is to lower the heart rate so that less blood is delivered into the aorta in a given time, thus assisting to maintain normal blood-pressure. In like manner, when the volume of blood is rapidly reduced from hemorrhage or venesection, the blood-vessel reflex immediately reduces the calibre of the arteries, so that within certain limits the blood-pressure is not altered. Terms and Definitions. Having briefly reviewed the physiology of the nor- mal circulation and the causes concerned in the pro- duction and maintenance of blood-pressure, we may 18 Terms and Definitions. now proceed to a consideration of the relation of these facts to the problems of clinical medicine and their bearing on Diagnosis, Prognosis and Treatment. To obtain a clear insight and understanding of the subject it is all-important to have an accurate knowl- edge of the terms applied to the matter under con- sideration. The Pulse. — The pulse is a rythmically recurring impulse arising in the systole of the left ventricle, and palpable through the arterial system. Its presence indicates a variation in blood-tension within the arter- ies, which causes them to pulsate, as the walls momen- tarily expand. Blood-pressure. — Blood-pressure is the term em- ployed to indicate the degree of pressure under which the blood exists while traversing the arteries. Unless otherwise specified, the , term blood-pressure as used throughout this book indicates arterial systolic blood- pressure. Systolic Blood-pressure. — Systolic blood-pressure means the degree of arterial pressure or lateral ten- sion existing in the arterial system at the moment of cardiac systole. Diastolic Blood-pressure. — Diastolic blood-pressure means the degree of arterial pressure or lateral ten- sion existing in the blood-vessels just preceding a sys- tole of the heart. This represents the time when the blood-pressure is at its lowest. Pulse-pressure^ Range or Amplitude. — These synony- mous terms indicate the amount of periodic variation in blood-pressure occurring within the arterial system, due to the intermittent action of the heart. It is equal to the difference between systolic and diastolic blood- pressures as determined by the sphygmomanometer. TkRMS and DkI'INMTION' 10 Mean Tension. — Mean tension is the term applied to indicate the average strain to which tlie arterial sys- tem is subjected. It corresponds closely to the arith- metical mean of the systolic and diastolic blood-pres- sure. The relation between these several terms ancl normal pulse tracing is shown in Fig. 1. stolic ^ 135 nge ^ 40 astolic = 95 Fig. 1 — Normal pulse tracing; showing relation of sys- tolic, diastolic, pulse-pressure and mean. Pulse-pres- sure equals 40. Normal Tension. — This term applies to the systolic blood-pressure which should be found in a normal individual as determined by the study of a large num- ber of persons. This pressure is modified by a number of normal or physiological conditions, and is therefore subjected to some variation. Full dis- cussion of these will be taken up in Chapter I\' page 54. Hypotension. — Hypotension is the term applied to the condition of the circulation in which the systolic blood-pressure is found to be below the normal as estimated for the individual. Hypertension. — Hypertension is the term applied to a condition of the blood-pressure when the level is maintained above the estimated minimum normal pressure. 20 Terms and Definitions. Auscultatory method. — By this is meant a method of determining both the systolic and diastoUc blood- pressure, with the aid of a suitable stethoscope (as the Bowles Midget or the sphygmometroscope, see page 41), the bell of which is placed over the bifur- cation of the brachial artery at the bend of the elbow below the sphygmomanometer cuff. THE FAUGHT SPHYGMOMANOMETER AND THE BOWLES STETHOSCOPE A clinician of national reputation has said in public that were he to be deprived of all the aids to diagnosis known to medicine save two, he would retain his sphygmomanometer and the stethoscope. He uses a FAUGHT SPHYGMOMANOMETER and the BOWLES STETHOSCOPE. CHAPTER III. THE SPHYGMOMANOMETER- The Principle of the Sphygmomanometer Circulator Compression Explanation of Systolic Reading Explanation of Diastolic Reading Description of Apparatus .... Mercury Column Apparatus Aneroid or Pocket Apparatus Description of Arm-Bands 21 22 22 23 24 25 28 31 Practical Application of Faught Aneroid Apparatus 29 Adjustment of Arm-Band . . . 31 The Systolic Reading .... 36 The Diastolic Reading .... 37 Auscultatory Method ... 38 Description of Tone Phases . 38 The Pulse Pressure 39 The Mean Pressure 39 The Sphygmometroscope ..... 40 Applied to Auscultatory Blood-Pressure . 41 The Multiple- Sphygmo- Metroscope . . 42 Practical Application of the Standard Sphygmoma- nometer ....... 43 Application of Arm-Band ... 43 The Systolic Reading .... 44 The Diastolic Reading .... 46 Fedde Diastolic Indicator ... 47 Points to be Remembered in Making Tests 48 Methods of Recording Blood-Pressure ... 49 Hospital Laboratory Sheet ... 50 Faught's Clinical Chart . . . . 51 22 Explanation of Systolic Reading. Fig. 2, A and B, shows the relation of the com- pressing bag to the artery. In Fig. 2, A, the pressure within the cuff is greater than the blood-pressure within the artery, which is therefore collapsed and the pulse in the distal end of the vessel cut off. In -Pressure in "b" 135 mm. Hg.; pressure in "a" 130 mm. Hg. B is therefore collapsed, pulse cannot pass. B. — Pressure "b" 129 mm. Hg.; pressure in "a" 130 mm. Hg. Pulse passes. Fig. 2 — Diagram of relations of armlet to brachial artery. Explanation of systolic reading; a, artery; b, compressing armlet; c, retaining cuff; d, tube to mano- meter; e, humerus. Fig. 2, B, the pressure in the cuff has been reduced so that it is a fraction of a millimeter less than the systolic pressure within the vessel. Now at each systole a small amount of blood will pass the con- Explanation of Diastolic Reading. 23 striction and will reach the distal end of the artery, where the wave can be felt by the palpating finger at the wrist. A. — Systolic pressure in "a" 130 mm. Hg.; pressure in "b' 101 mm. Hg. Artery not compressed. B. — Diastolic pressure in "a" 100 min. Hg.; pressure in "b" 101 mm. Hg. Artery collapsed. Fig. 3 — Diagram of relation of armlet to brachial artery. Explanation of diastolic reading; a, artery; b, com- pressing armlet; c, retaining cuff; d, tube to mano- meter; e, humerus. Fig. 3, A and B, represents the conditions existing between the constricting cuff and the vessel at the time of diastolic pressure. A represents a pressure within the cuff less than the systolic pressure in the 24 Methods of Reading. vessel. This is insufficient to affect the vessel during the systolic period. B shows the artery and cuff dur- ing the diastolic period, when the pressure within the artery is at its lowest point, a fraction of a millimeter less than the pressure v/ithin the cuff. Consequently the artery is collapsed at this time. The effect of each succeeding systole is to alternate between a round and a flat vessel at the point of compression. This aft'ects the pressure of the air within the cuff, w^hich is in turn transmitted to the mercury column of the manometer and becomes visible in the rhythmic fluctuation of the column of mercury which is syn- chronous with the pulse beat. Since the fluctuation will reach a maximum at the time when the pressure in the cuff is approximately equal to the diastolic pressure in the vessel, we are justified in considering the base of the manometer column at this time a measure of the diastolic pressure within the vessel. Since the development of the visual or oscillatory method of diastolic blood-pressure observations newer and better methods have been designed. These are the tactile, the auscultatory and that by means of the Fedde indicator attachment. Each of which will be considered more fully later under the head of ''appli- cation of the blood-pressure test." Description of Apparatus. — At the present time the market is flooded with instruments of all descriptions for estimating blood-pressure, so that it is important that the prospective purchaser should be able to separate the good from the bad, since the imperfect and poorly constructed instrument will be a constant source of inconvenience and may give very incorrect readings. Mercury Api'aratus. 25 All these instruniciils may be roughly divided into two classes : First, those dej)endent upon the weight of a fluid column (usually mercury) which measures the pressure ; and, second, those employing some form of spring or aneroid chamber. Fig. a — Type of Mercury IManometer employing a verti- cal tube. A, mercury-containing base; B, manometer tube; C, tube to armlet; D, tube to bellows; E, scale. Taking up the first class, we find that this can be divided into two divisions; one employs a vertical glass tube emerging from the mercury chamber so that when pressure is exerted on the mercury, it is forced upward into the glass tube, where the pressure is indicated in millimeters of mercury by an appropri- ate scale attached thereto (see Fig. 4). 26 Faught-Pilling Sphygmomanometers. The second group of mercury instruments employ a glass U-tube similar to that first used by Poiseuille Fig. 5 — Manometer Ar-FiG. 6 — ]\Ianometer Ar- rangement of Pilling Spe- rangement of Faugh t cial Sphygmomanometer. Standard Sphygmomano- meter. (see Fig. 6), with the open ends up. This tube is partly filled with mercury and one limb is connected by means of suitable tubing with the rest of the Accuracy of Mercury Apparatus. 27 apparatus. Pressure exerted within the system will cause the mercury to rise in one limb of the tube with a proportionate fall upon the other. The difference in the level of the mercury in the two limbs will repre- sent the pressure, which may be measured by a suit- able scale placed between the tubes. These two types depending upon a vertical column of mercury have little to choose between them, and both are accurate and trustworthy at all times. The mercury at rest freely communicates with the atmos- phere, and is therefore not afifected by barometric or thermometric changes. A question has been raised by some regarding the accuracy of the cystern-vertical-tube-type of mercury sphygmomanometer in the high readings. It has been found that the fall in the mercury level in the cystern affects slightly the total height of the mercury column, so that in readings above 250 the figure obtained with this type of apparatus may be from 5 to 10 mm. too low. After all, this is not such a great draw- back, as the variation is slight at best, and because such pressures are but rarely met in the course of general practice. Value of Mercury Apparatus in Determining Diastolic Pressure. Some time ago there appeared an article in which the value of the fluctuation of the mercury column for determining diastolic pressures was questioned ; this was based upon the supposed interference of the inertia of the mercury column. The author of these statements failed to recognize the fact that the mer- cury column at the time of the observation was under 28 Faught Pocket Sphygmomanometer. an added factor of pressure and that this pressure exerted against the mercury column greatly reduced the enertia factor. By experiment it was found pos- sible for the mercury column to shozv a fluctuation from successive systolies up to nearly 200 heats per minute, or more than twice the number possible with a mercury column moving freely in the atmosphere. Anyone, by actual experiment, can demonstrate this with any form of mercury apparatus, so that one need not fear to use a mercury apparatus when em- ploying the visual method for diastolic reading, unless the pulse is so rapid that it is uncountable; this does not mean that the visual method is recommended, but simply that when no other , means is available, the results by this method will be reasonably accurate and clinically satisfactory. Aneroid or Pocket Type. — There are also several types of instrument, employing some form of spring and aneroid chamber, actuating a dial indicator for the recording of blood-pressure in millimeters of mercury. These are the so-called pocket instruments, and have much to recommend them, provided they do not become inaccurate by use. The Faught Pocket Sphygmomanometer consists of a gold-plated aneroid gauge with a white enamel dial bearing black and red markings graduated to 300 mm. Hg., a strong flexible sleeve and a metallic inflating pump, together with suitable rubber tubing for con- nections. Vv^hen assembled these constitute a very simple and most reliable instrument, so compact that it is contained in a leather case, measuring 8 x 3^ x 1^ inches, and weighing complete about one-half pound, fitting easily in the pocket or bag. Accuracy of Pocket Sphygmomanometers. 29 This instrument has been devised to fill the long- felt need of a Pocket Sphygmomanometer, which would combine portability and accuracy with durabil- ity and strength. The Faught Pocket Sphygmomano- meter is an exact and efficient instrument, and is employed extensively by life insurance examiners, hospitals, the army and navy, bureaus of health and by most of the leading practitioners. It is compact, absolutely accurate, very sensitive, substantially con- structed, and with ordinary care should last a life- time. It is unfortunate for the medical profession that a certain type of aneroid type of instrument which at first met with favor has been found in many cases to lose its accuracy and to become untrustworthy through frailty of construction, which renders it easily deranged. Even ordinary use will at times develop in this particular make of instrument perma- nent inaccuracy. Failure of a single type should not, however, con- demn all instruments operating upon the aneroid principle, as the test of time so far has failed to show any such disturbance in the aneroid made by the Pilling Company; for example, a Faught instrument was used for ward class demonstration for more than a year, and when tested with the original stand- ard mercury column was found as absolutely accurate as zvhen originally tested. At another time, after one hour's constant use on about twenty students, a test for accuracy was immediately made, and the readings corresponded absolutely, both up to 300 and down again. This proves conclusively that the Faught Pocket Sphygmomanometer is not af- 30 Durability of Faught Sphygmomanometers. FECTED BY CONSTANT USE AND THAT READINGS BOTH UP AND DOWN ARE IDENTICAL. No Other ancroid can bear these tests. J. F. Prendergast, commenting upon the accuracy of the Faught Pocket Sphygmomanometer, states : "As FOR ACCURACY AND DURABILITY, THE WRITER HAS FOR THE PAST FOURTEEN MONTHS USED ONE ANEROID IN- STRUMENT, A Faught, and has forced it up to 450 MM. nearly TWO THOUSAND TIMES. AfTER THIS SEVERE TEST IT WAS COMPARED WITH A STANDARD MERCURY COLUMN AND FOUND AS ACCURATE AS AT THE ORIGINAL TEST. It IS STILL IN SPLENDID WORKING CONDITION, AND THE COMPRESSION DIAPHRAGMS ARE AS RESILIENT AS THE DAY IT LEFT THE PiLLING FAC- TORY. This is a test of the most severe character, AND ANY INSTRUMENT THAT WILL REMAIN ACCURATE WITH SUCH USAGE WILL LAST INDEFINITELY WITH ORDINARY USE." Fig. 7. — Faught Pocket Sphygmomanometer in Case. A very important and distinctive feature possessed by the Faught Pocket Sphygmomanometer and found The Flexible Arm-Band. 31 in no other instrument of similar character is the abso- lute elimination of the so-called "fatigue of metal" which heretofore has interfered with the accuracy of all other aneroid instruments. By persistent experi- ment and painstaking study a material for the con- struction of the compression disks has been found which is not affected in any way by temperature or pressure variations. These tests can be repeated by anyone and the results will be the same. Try them and be convinced. The Arm-band is made of strong grey inelastic, but soft and flexible material, having between its layers a rubber bag 9 x5 inches. This measurement conforms to the requirements of Janeway and others, and has been found to give the most accurate readings under all conditions. Fig. 8. — Arm-band. The Faught Pocket Sphygnioinaiwiueter can be applied or removed in less than thirty seconds. The lime required to apply the instrument, make a careful observation of the pressure and remove it is less than consumed by any other form of sphygmomanometer on the market. Two years' experience with the Faught Pocket Sphygmomanometer has demonstrated conclusively 32 Faught Pocket Sphygmomanometers. the superiority of the internal mechanism of this in- strument as compared with all other types of aneroid. They have been found practically indestructible as well as uniformly correct. Many instruments in con- stant use — thousands of times — coming back for examination, are found to have retained their accur- acy when compared with the standard mercury column. Fig. 9. — Pocket Indicator. Actual size. For accuracy and sensitiveness, the Faught aneroid has all the advantages of the best mercurial instru- ments ; for compactness and durability it far surpasses them. It is practically indestructible, and is well adapted to use in the operating room and in private practice, as well as in hospital service. Faught Clinical Sphygmomanometer. 33 Reads up to 300 mm. — The dial, which is accurately graduated, reads in mm. Hg., as does the standard mercury column, each interval representing two mm., and ranges from zero to three hundred (Fig. 9). The dial also may be revolved without interfering with the internal mechanism, so that the pointer at rest can be adjusted to zero. Neither temperature nor atmospheric variation in any zvay affects the apparatus, since when at rest the pressure on both side of the pressure chambers is equalized. Fig. 10. — Clinical Pocket Sphygmomanometer. One-half actual size. Diameter of dial, ?>% inches. The latest development in sphygmomanometers is the "Faught Clinical." This instrument follows a new principle which has been fully tried during several years in the Faught Pocket Indicator, and which has been fully demonstrated to be the most desirable and accurate multiple chamber aneroid instrument yet designed. This instrument is shown in detail in Fig. 10. 34 Standard Mercury Sphygmomanometer. The two characteristic features of this instrument are the large, easy-to-read dial, measuring 3^ inches working diameter, and a graduated scale with a range of 350 mm. Hg. The first and only sphygmomano- meter to have a range sufficient to give accurate read- ings in every case, as it is now well established that pressures are not infrequently encountered that regis- ter well above 300 mm. (See article in New York Med. Jour., June 11, 1910, by John C. Hirst.) In general appearance the Clinical very much resembles the Pocket and, in spite of the larger scale, is contained complete with pump and arm-band in a case but very little larger than that of the Pocket Indicator. The Faught Standard Mercury Sphygmomanometer is modeled after the U-tube type of apparatus and is designed to overcome the defects of the earlier instru- ments, to meet every requirement demanded of a mod- ern sphygmomanometer and at the same time be easy to use, difficult to derange and as light and portable as is compatible with accuracy and strength. The mahogany case, which encloses the complete apparatus, including the arm-band (see Fig. 11) and pump (see Fig. 16), measures 4x4^ x 16 inches and weighs 3 pounds 9 ounces. The lid is hinged at one end and when raised supports the working parts of the apparatus. A spring check allows the lid to be raised to a vertical position, where it is automatically held locked during the observation. The "U" tube is provided with a scale which has been arranged to give the reading directly in milli- meters of mercury. Faught Mercury Sph ycmomaxomftkh. 35 A special and distinctive feature of the apjjaralus is the means of preventing loss of mercury from the manometer tube when the instrument is not in use. This is accomplished by means of two small cocks placed at either extremity of the "U" tube, and which are kept closed wlien the apparatus is not in use (see Fig. 6). Fig. 11 — Faught Standard Sphygmomanometer. By eliminating all detachable parts, the time re- quired to make the reading is reduced to a minimum. The only preliminaries to the test being to lift the lid, open three cocks and attach two tubes to their respec- tive nipples. Z6 To Obtain a Systolic Reading. To Operate the Faught Pocket and the Faught Clinical Sphygmomanometers. Apply the arm-band to the bared arm of the patient, above the elbow, by placing the broad end, containing the rubber bag, over the region of the brachial artery. Wrap the rest of the band as you would a bandage about the arm (see Fig. 12) and tuck the narrow end in under the first turn. Attach the indicator to the hook provided for that purpose; attach the pump to one nipple, and the tube from the arm-band to the Fig. 12. — Pocket Indicator Applied to Arm. other. See that the needle valve on the pump is fully closed. Hold the pump in one hand and locate the pulse at the wrist with the other. You are now ready to take the systolic pressure. To obtain systolic reading. — Pump sufficient air in the system to obliterate the pulse, then by a fraction of a turn open the valve (see Fig. 12), gradually release the air pressure, and note the pressure indi- cated when the first pulse beat returns to the wrist. This is systolic pressure. Repeat the procedure one or more times to insure correct readings. Work rapidly, as prolonged pressure upon the arm will affect the reading. To Obtain a Diastolic Reading. Zl To obtain diastolic reading. — Again obliterate the pulse and allow the air pressure to gradually fall through the needle-valve. As the pressure falls the needle will be seen to fluctuate in rhythm with the pulse ; after a time this movement will become less and eventually disappear. The pressure indicated on the dial at that time will be the diastolic pressure. Obliterate the radial pulse, then gradually reduce the air pressure ; when the pulse returns to the wrist it will at first be very feeble and thready, then it will come up full and strong under the finger. Take the reading at the moment the pulse becomes full and normal in character. This will be the diastolic pressure. The value of correctness of the ausculatory method of determining blood-pressure has, during the last few years, been conclusively demonstrated. This was first introduced by Korotokoff, of St. Petersburg, in 1905, who, instead of using the finger upon the radial pulse, substituted the stethoscope applied over the brachial artery at the bend of the elbow. On the return of the blood under the armlet, a distinct throbbing becomes audible, which gradually increases in loudness as the pressure in the cuff lessens, and then gradually dies down and disappears when the artery ceases to be obstructed at any time during the heart cycle. The chief advantage of the auscultatory or auditory method is in that it gives not only the high point — the systolic pressure — very definitely, but also the low point — or diastolic pressure, a point of great value, since it is well recognized that, under many condi- tions by the older methods, it is impossible to obtain 38 Auscultatory or Auditory Method. any accurate diastolic pressure, and in some cases no diastolic reading at all. The importance of this is further emphasized by the fact that the diastolic pressure is often the more important reading, since it gives the pulse pressure or amplitude, which is an indication of the actual force and volume of the circulation. Clinical studies by Goodman and Howell in the American Journal of Medical Science, 1911, and by Warfield and by H. G. Armstrong in the Journal of the A. M. A. and British Medical Journal, are sufficient to assure us of the value of the auscultatory method. For the benefit of those who desire to go into this study more exten- sively than is really necessary for clinical work, the following analysis of the sounds is given. These consist of five phases, which are clean cut and which have a definite relation to the differences be- tween the extremes of pressure. With a normal systolic pressure at 130 mm. and a diastolic pressure at 85, the phases are : First, a loud, clear, snapping tone, which is the first phase. This serves as an index as to how far the pressure must fall before the column of blood can be sustained past the obstruction in the vessel caused by the cuff, at sufficient velocity and for suf- ficient duration to produce the murmur. Normally this phase covers 14 mm., and any increase or decrease in length should be noted. The advent of this sound indicates the systolic pressure. The Second Phase consists of a succession of mur- murs, covers 20 mm. and is dependent upon cardiac effectiveness. The Mean Pressure. 3^ The Third Phase is a tone resembling the first phase, but less marked and lasts 5 mm. This is dependent upon cardiac efficiency and also upon the character of the vessel wall. The more sclerotic the vessel and the greater the cardiac hypertrophy, the more favor- able are the conditions for the production of a clear tone at this time. The Fourth Phase occupies about 6 mm. and is heard as a dull tone ; a resilient vessel receiving a normal pulse shock, or a rigid vessel receiving a weakened shock. The pointer at this time indicates the diastolic pressure. The Fifth Phase is the disappearances of all the sounds. Of these three methods, the last is the more accu- rate and scientific. One point, however, must be borne in mind : readings in the text books and medical literature are based on the first and second methods. The auscultatory method will give readings of a slightly higher systolic pressure and a diastolic pressure of 10 to 15 mm. lower. Having determined the systolic pressure and the diastolic pressure, the diastolic pressure is subtracted from the systolic pressure and the remainder is the pulse-pressure (see Fig. 1, page ig). To obtain the mean pressure, add one-half of the pulse-pressure to the diastolic pressure (see Fig. 1), In order to enable physicians to take the blood- pressure readings more accurately and to make them of greater clinical value to the profession as a diag- nostic and therapeutic guide, Dr. J. F. Prendergast {N. Y. Med. Jour., Jan. 11, 1913) has had devised and placed on the market the Sphygmometroscope (Aus- 40 The Sphygmo-Metroscope. culoscope). It consists of a two-inch band, to which is attached a metal bowl or cup, the face of which has a very delicate diaphragm, with a centre projec- tion to fit more snugly to the surface of the arm over the brachial artery, just at or below the bend of the elbow. Flexible rubber tubes are connected with the Fig. 13. — Method of auscultatory blood-pressure test, using Faught pocket indicator and sphygmometroscope. drum or body of the instrument, to which are attached hard-rubber ear-pieces (see Fig. 14). It is called the Bowles sphygmometroscope, and resembles the Bowles stethoscope with certain modifications; it is attached to the arm by a two-inch band. The instrument is intended for use with any kind or form of sphygmomanometer, either pocket or mercury. Its method of application is to place the band on the arm one or two cm. (one-half to one The S'phygmo-Metroscope. 41 inch) below the arm-l)an(l or cuff of the sphygmoman- ometer at the bend of the elbow, having the projection on the diaphragm of the drum directly over the brachial artery before it divides into the ulnar and radial. Care should be taken to avoid pressure from this band upon the arm. Fig. 14. — Sphygmometroscope. Pump the cuff, connected with the manometer, with air until the radial pulse is cut off, open the release valve and allow the air to escape slowly from the arm-band. The first impulse or sound heard is a clear thump or tap, caused by the sudden stretch- ing of the walls of the relaxed vessel and the rapidity of the blood stream. This is the systolic pressure. Where one is merely trying to read the systolic and diastolic pressures, it is not necessary to attempt to interpret the different phases. The essential thing to remember is that the first tap or sound is the systolic pressure, and just at the disappearance of all sounds is the diastolic pressure. 42 The Multiple Sphygmo-Metroscope. Goodman and Howell say: "The auscultatory method is useful in differentiating certain organic and functional derangements. It was found that any arrhythmia which may be present is noted earlier by Bowles \ I \ /multiple Sphymo^metroi^scope Fig. 15. — The Multiple Sphygmometroscope. the auscultatory method than by feeling the pulse or listening to the heart. By this method true organic cardiac lesions can be differentiated from a neurosis. In organic lesions there is a uniformity in sequence of readings ; in neuroses the readings are marked by variations in sequence and a variation in the systolic and diastoHc pressures." The Multiple Sphygmometroscope. — The accompany- ing illustration, Fig. 15, represents a new device to facilitate the teaching of blood-pressure readings by the auscultatory method. The chief drawback to the ausculatory method has been the seeming difficulty which the average physician has in learning to per- ceive and interpret the sounds heard over the artery. Opkration of Standard Sphygmomanometer. 43 Tlie idea suggested itself that if the si)hygmometro- scope were made into a multiple of four, whereby the sounds could be heard by more than one individual at the same time, it would overcome this difficulty and make it possible for anyone familiar with the sounds heard during auscultatory blood-pressure ob- servations to direct the attention of a small group of observers during the actual performance of the test. The G. P. Pilling Company, of Philadelphia, have taken up this suggestion, and this valuable instrument is now upon the market. The device will be valuable particularly to the medical teacher, as it has been our experience that many students go through their clinical studies with- out ever actually hearing or seeing what is demon- strated. It is serviceable also in demonstrating to med- ical societies or groups of medical men conditions in- volving marked variations in pressure. To Operate the Standard Sphygmomanometer. The patient should be in a comfortable position and in a sitting or reclining posture. The instrument should be upon a level surface within easy reach of the examiner. The lid is then raised until it locks in a vertical position. If the tube from the pump is not already connected to the nipple F, it should be firmly attached to it. The two mercury guard cocks K and L at the ends of the ''U" tube should be opened and the escape valve N tightly closed. The hollow rubber bag of the arm-band A should be firmly wrapped around the bared arm of the 44 Systolic Reading. patient and securely bound there by the leather cuff and straps B (see page 89). The cuff should be applied snugly, but not with pressure, as it is not de- signed to compress the member, but only to restrain the inner rubber bag while pressure is applied to it. The tube from the arm-band C is attached firmly to the nipple D. The cock in the nipple F is opened. Fig. 16. — A, inner arm-bag. B, outer retaining cuff. C, tube from arm-band. D, nipple for tube from arm- band. P, pump. F, nipple for pump tube. G, milli- meter scale. H, manometer tube. I, link-brace and lock. K, mercury guard cock. L, mercury guard cock. M, pressure guard cock. N, release valve. This arrangement forms a continuous closed pneu- matic system communicating freely with the mano- meter tube of the instrument. Now when pressure is raised in the arm-band by the hand-pump, the amount of force exerted is indicated by the rise of the right-hand column in the manometer tube H, the height of which will be indicated on the scale G in millimeters of mercury. Systolic Reading. — With one hand find the pulse at the wrist of the arm, to which the arm-band has been Systolic Reauinc:. 45 applied. The fingers should be in a comfortable posi- tion and under no circumstance should be moved during the observation. Care should also be observed that the pulse is not cut off by undue pressure of the palpating fingers. The cuff should be in the same horizontal plane as the subject's heart. ANEROID Fig. 17. — Diagram of internal mechanism, showing com- pression chambers. Note the fact that in this instrument the pressure itself is applied on the outside of the metallic chambers, so that they are compressed and not expanded, in propor- tion to the degree of compression force exerted. While the pulse is thus under observation, the pressure in the apparatus is raised by means of the hand bellows or pump until the pressure within the constricting band is sufficient to prevent the impulse from reaching the wrist. When this is accomplished the cock in the nipple M is closed to eliminate the elastic pressure. Now by a fraction of a turn in the valve N the pressure in the system is slowly released. During this part of the procedure, a close watch 46 The Diastolic Reading. should be kept upon the height of the mercury column and for the return of the first pulse beat at the wrist. The level of the mercury column at the instant that the pulse passes the compression-band will represent the systolic pressure in the vessel under observation. It is advisable to repeat this procedure a few times to check the correctness of the finding. The diastolic pressure may be obtained in several ways. The method employed will depend upon the character of the instrument used and the method preferred by the operator. The readings obtained by this instrument correspond closely to those obtained by auscultation. The methods will be described in the order in which they have been devised. The visual method depends on the to-and-f ro motion imparted to the mercury in the "U" tube, which occurs after the pressure has fallen below the systolic point. Having determined the systolic pressure, again raise the pressure to a few millimeters above this point and immediately close the valve M. Now allow the pressure to fall very slowly by releasing the air through the valve N. As the mercury falls below the systolic point it will be noted that it acquires a rhythmic motion corre- sponding in time to the pulse. This will be found to gradually increase in amplitude up to a certain point, after which it decreases and finally ceases before zero pressure is reached. During this gradual fall the base of the mercury column, when the mercury is making the greatest excursion, represents the diastolic pressure. These are the same as are described under Pocket Apparatus on page 36. The Fedde Indic. 47 By Diastolic Indicator. — This is very similar lo the visual method, except that the movement of the mercury column is ignored and the movement of the pith ball in the small vertical tube relied upon to de- termine the diastolic pressure. By reference to Fig. 18 it will be noted that the narrow perpendicular glass tube contains a small, light ball of pith or cork, which is free to move up and down within the tube. Fig. 18. — Fedde Indicator as Component of Standard Sphygmomanometer. When determining the systolic pressure pay no attention to this indicator, as each impact of air will make the ball dance violently, but this has no bearing on the test. When the pressure has reached the systolic point, close the valve N, when the ball will begin to move slightly in rhythm with the pulse. This motion gradually increases, until it reaches a maxi- mum as the level of the mercury column gradually 48 Details of Test. falls, when, quite suddenly, its motion becomes markedly less. At the moment of this reduced move- ment the level of the mercury will indicate the diastolic pressure. Cautions. — To obtain accurate and reliable clinical data with the sphygmomanometer, it is important that some systematic technic be adhered to, and that all observations not only on the same patient, but in all cases, be made under as nearly the same conditions as possible. Attention to detail will eliminate largely the errors arising from such factors as position of the patient, presence of fatigue or mental excitement, arm used for observation, etc. It is also valuable to note the apparatus used, the time of day, the pulse rate, the sex and age of the patient. It is important that the location of the cuff should be at the heart level, otherwise the reading will be affected by the weight of gravity on a column of blood, being higher or lower, according to whether the cuff is above or below the heart level. The further the cuff is below the heart level the higher the reading. Position of Patient. — From the studies of Sandford and others, as recorded on page 55, it will be seen that the position of the patient is of great importance, as the systolic pressure under the same conditions rises from 5 to 15 mm., as the posture of the patient chances from the standing to the recumbent posture. Continued constriction of the arm by the cuff for more than a minute or two will provoke vaso-motor changes in the member, which may cause a rise of from 5 to 10 mm. in subsequent readings. Another point of importance in connection with the Recording Observations. 49 actual use of the blood-pressure apparatus is that when taking the systolic pressure the reading should never be made as the pressure is being raised in the cuff, but only after the obstruction of the vessel is com- plete by the air in the cufT and while the column is returning by means of the escape of air through the valve. Experience has shown that there is a differ- ence of several millimeters between readings made in these two ways, and that the reading taken at the moment of the return of the first impulse at the wrist is the true systolic pressure. No single reading should be accepted when it is possible to make more than one. It is better to see the patient a number of times under varying condi- tions before deciding what his blood-pressure is. The following printed record form has been taken from the Author's Work on Essentials of Laboratory Diagnosis, 4th edition, F. A. Davis Co., Philadelphia, 1912. This will be found useful for keeping a com- plete record of the Blood-pressure Test, also the chart as shown in Fig. 19 (page 51) is valuable where a series of observations are made upon one patient. This chart is arranged to keep the readings in graphic form, similar to the usual temperature chart. Some observers prefer the graphic charts which show the variation in blood-pressure and pulse in the same manner as a temperature chart. The accompanying cut shows a chart which has been carefully prepared and which is arranged to show both systolic and diastolic pressure, together with pulse rate, in such a manner that they do not become superposed. These may be obtained on the market in pads of 25 for a nominal figure or directly by writing to G. P. Pilling & Son Co., Philadelphia. 50 Clinical Report Form. BLOOD-PRESSURE DETERMINATIONS Clinical Report Apparatus \ Width of Cuff cm. Part examined, Right, Left, Posture, Pulse Rate, Systolic mm. Hg. after 10 bending movements. mm. Hg. Diastolic mm. Hg. after 10 bending movements. mm. Hg. Pulse Pressure mm. Hg. after 10 bending movements, mm. Hg. Mean Pressure mm. Hg. after 10 bending movements, mm. Hg. Remarks. Time of Day, A. :\r P. M. Date Examined by Graphic Cii. 51 FAUGHT CHART I OR BLOOD-PRESSURE RECORDS. PULSE. TEMPERATURE AND BLOOD PRESSURE CHART COLOR ^ o"o":o"'s°'*Jr ..CX>.V,v«.v^; —-"^^^^-■^^ .r^ /^■^ -t^ >'* 3 4 s- t. » /I 6 «• /I t 8 11 , =»= IS - i =» s i P 215 108 270 107 265 106 ), f 255 I0< / V 3 \ l' u "^ '"Tc-r,« / \ / \/ 2,5., 02^""' J9 235 2 100 2X>^ 99 _ _ __ 1 _ — 1 — — n — - — - — - - — — - 215 96 205 200 200 ^190 ,90 ',85 ,85 S,75 ,75 a 170 ,70 §.60 ,60 1 i t 1^/ L '^' N I 't "° '» TJnr ^ \ ,/ ,^^ •^ L— * U ,25^,25 > r »•-" : J N(R XAL B ao 1 PR SSU IE ,.5^„5 ■ "^ 105 ,05 P 100 ,00 »•■ S 1 95 95 1 90 90 , (-- 85 SSppp f 80 OO*" " 1 75 75 65 65 ■ rULSE PRESSURE H ^t jt w Vi3J ^i^:^^ H»' I J_ t In -J I ) Ct 1 2 Scnk Fig. 19. — Blood-pressure recording chart, about one-eighth actual size. Designed to record systolic pressure, dias- tolic pressure, pulse rate and temperature. Published by G. P. Pilling & Son Co., Phila., Pa. CHAPTER IV. NORMAL BLOOD-PRESSURE AND ITS VARIATIONS. Definition of NormsJ Pressure .... 53 Average Normal Pressure for Any Age 54 Factors Affecting Normal Average Blood-Pressure . 54 Sex 54 Physical Condition 54 Exercise ....... 54 Sleep and Rest ...... 54 Posture 55 Time of Day . ". . . . . 57 Consumption of Fluids . . . . 57 Age 57 Altitude and Atmospheric Changes . . 57 Ingestion of Food 59 Consumption of Alcohol .... 59 Use of Tobacco ..... 60 Extent of Permissible Variation .... 60 Determination of Abnormal Pressures . 61 Arterial Hypertension .... 61 Arterial Hypotension . . < . . 62 CHAPTER IV. NORMAL BLOOD-PRESSURE AND THE CAUSES OF VARIATION. When normal blood-pressure is spoken of in discussion, it is accepted to mean that the pressure in each individual case is within the recognized normal limits determined by clinical experience. This is not and cannot be a fixed pressure, as the normal tem- perature is a fixed degree. This is because blood- pressure at any given moment is the result of a com- bination of variable factors, which must unite to de- termine it, and because it has been found by experi- ence that blood-pressure is regularly influenced and modified by the age and sex of the individual. There are several methods of arriving at an estima- tion of the normal pressure and its variations in a given case. Thus we can adhere to a table based on a large clinical and experimental study. Such a table, which conforms to the accepted standard, has been compiled by Woley. Method of Estimating Normal Average. — The normal average systolic pressure can be readily determined for all ages by employing a formula devised by the author several years ago. This is based on the experi- mental study of many observers, and is designed to 53 54 Factors Affecting Blood-Pressure. estimate the age factor thus : ''Consider the normal systolic blood-pressure of a healthy adult male, age 20, to be 120 mm. Hg. . Then for any two years of life over this add 1 mm. Hg. to 120. Thus at age 30 blood-pressure equals 125, at age 60 it equals 140, etc." The Sex Factor can be roughly reckoned as minus 10, so that all pressures as computed by this formula should have 10 mm. subtracted when estimat- ing the average normal pressure for women. It is accepted that other factors which are usually part of the daily life of an individual will somewhat influence the blood-pressure ; thus : Physically weak persons will usually show a slightly lower pressure, often 5 to 10 mm., while the MUSCULARLY DEVELOPED wiU havc a sHghtly higher average, about 5 to 10 mm. The pressure after Exercise will be found from 10 to 20 mm. above the average, but will rapidly return to normal. The same may be said of the first hour after a hearty meal. Effects of sleep and rest on Blood-pressure. — Brooks and Corroll (Arch, of Int. Med., August, 1912) studied this effect in 68 patients, showing average systolic pressures in 30 with low pressure and 20 with abnormally high pressure. The results in the general way are illustrated in the cases with average pressure. Readings were taken from 1 to 2 hours after the beginning of sleep and showed an average fall of 24 mm. ; three hours after waking in the morn- ing there was still an average depression of 12 mm. In these persons the pressure gradually rose to its high level in the afternoon. Posture on Blood-Pressure. 55 The greatest nocturnal fall in ])rcssure took place in cases having the highest initial systolic pressure. Disturbance of the patients during the first sleep delays, but does not necessarily prevent the fall. Frequent interruption, however, does prevent it. The use of hypnotic doses of drugs to produce sleep, as 120 grains of bromide of potassium or chloral hydrate up to 50 grains each night, did not increase the degree or persistence of the fall. Physical rest in general did not appear to alter materially either the subnormal or normal blood-pressure, but the authors were led to believe that mental and physic rest might cause profound changes in pressure and that these factors largely determine the undoubted benefit derived from rest in cases of high pressure. Posture will affect the reading, and its effect is largely, if not entirely, due to the effect of gravity and the relation of the arm-band to the chief volume of blood in the body. The effect of change of posture without active mus- cular exertion on arterial pressure was reported by J. H. Barach and W. L. Marks in Archives of Inter- nal Medicine, May, 1913. Without going into the methods employed in obtaining these conclusions, it is sufficient to say that the mercurial type of instrument was used with a 10 cm. cuff, that the methods were carefully checked by controls and that any outside factors which might influence the results were eliminated, as far as pos- sible, and that all readings were repeated in order to eliminate accidental error. 56 Summary of Effects. The summary of results is as follows : 1. When the element of muscular effort has been eliminated, change of bodily posture from the erect to the horizontal will cause an increase in the maxi- mum pressure, a decrease in the minimum pressure and an increase in the pulse pressure. 2. After five minutes in the horizontal posture, when the subject is returned to the erect posture, the maximum pressure will diminish, the minimum press- ure increase and the pulse pressure diminish. It will be noted that in both instances the pulse pressure fol- lows the same trend as the maximum pressure. 3. Change of posture from the erect to horizontal caused a fall in the venous pressure. 4. Change of posture from the horizontal to erect caused an increase of the venous pressure. It will be noted that the venous pressure follows the same trend as the minimum pressure. Nearly all subjects of this series responded in the same way. The most notable exception was in the "Poor Muscular Cases." These cases showed a ten- dency to a reversal of the pressure curve. Form erect to horizontal caused, in more than half of the cases, a decrease of the maximum pressure and an increase of minimum pressure. General Summary. Erect Horizontal Erect Maximum + + — Minimum + "~ + Pulse pressure + + — Venous pressure + — + Age on Blood -Pressure. 57 Time of day has a modifying influence on blood- pressure, being usually lowest during the early hours of profound sleep, rising slightly toward morning, and rising more or less rapidly, depending on the mental and physical activities of the individual, as the day advances. This variation may reach as much as 40 mm. Hg. Ingestion of large amounts of fluid, particularly if Alcoholic, will cause a moderate and brief rise. Pain and anxiety are often a cause for a sharp and short rise. Age. — The following table is taken from L. Gor- don, who has made extensive study of the relation of age in normal children to blood-pressure. mm. Under one year 71 One year Th Two years 79.3 Three years 81 Four years 83 Five years 86.5 Six years 88.5 Seven years 85.0 Eight years 93 Nine years 100 Ten years 95 Eleven years 104 Twelve years 105 Effects of Altitude and Atmospheric Changes on Blood- Pressure and Pulse Rate. — Hoobler and Pomeroy, in a review of literature combined with their own obser- vations on the effect of Barometric Pressure on blood-pressure, state that ''the result of nearly all 58 The Climatologic Effect. experimental data shows that diminished barometric pressure lowers blood-pressure." C. F. Gardner has shown that a person going from an elevation of 6000 feet to one of 14,000 feet suffers a fall in blood-pres- sure and a rise in pulse rate. The results of Schnei- der and Hedblom are the same. They state also that the diastolic pressure tends to be lower by reduction in barometric pressure. That the fall in systolic pres- sure was slightly greater and more certain to occur than the fall in diastolic pressure. This effect be- comes less marked as the subject becomes accustomed to the change. The change usually amounts to from 3 to 10 mm. ; occasionally as much as a 20 mm. rise has been noticed. In tuberculous subjects with hypotension, high alti- tude (6000 feet) causes a rise in pressure (Peters, Arch, of Int. Med., Aug., 1908). Colis and Pembrey have studied the important fac- tors of Relative Humidity in the atmosphere to blood-pressure, and have found, by studies made in England, that when the Actual Humidity was greatly increased, a rise in pulse rate of 30 or more beats per minute not infrequently occurred, and there was also an increase in respiratory rate of from 18 to 29. The same results were noted when the actual humidity was increased. P. P. Aminet examined a large number of healthy children of from 7 to 15 years of age in an effort to determine the effect of outdoor life on pulse and blood-pressure. He found that almost uniformly there was an increase in blood-pressure and in pulse rate. The pressure elevation amounted to as much with some cases as at 30 mm. Hg. Children living in Alimentary Hypertension. 59 good surroundings have a generally higher blood-pres- sure than those in poorer environments. The same condition was noted by Hoobler in children suffering from tuberculosis or pneumonia. Starling has studied the ejfect of wind-pressure upon the systolic blood-pressure, which has a very important bearing upon the effect of this condition upon cardiac cases. He found that wind-pressure has a profound influence in raising pulse rate. The same may be said of the effect of wind-pressure upon the blood-pressure. Eating. — The blood-pressure normally rises from 10 to 15 mm. shortly after an ordinary meal, gradually falling toward the original level after an hour or more. The size of the meal is thought by some observers to affect the degree of elevation, being greatest after heavy meals which contain much proteid. It is well recognized that certain changes in the circulatory system originate from disturbances in the digestive tract. These are usually seen in a slight increase in blood-pressure, due to the reflex from the splanchnic area affecting the muscular walls of the arteries. This may be considered normal to a certain degree, but it becomes pathologic where we find this elevation to be excessive and prolonged. Alimentary hypertension is the result, therefore, of a normal abdomino-arterial reflex, made excessive by an over-abundance of food or an incomplete elimina- tion of toxic substances. This continued hypertension is often the first link in the chain leading to arterio- sclerosis, contracted kidneys and apoplexy. Drinking. — Excessive ingestion of water causes a brief rise of blood-pressure, amounting to about 5 to 60 Tobacco on Blood- Pressure. 10 mm., although the habitual use of ordinary amounts need hardly be considered in any blood-pressure esti- mation. Large amounts of beer may be the cause of a sharp rise, which, when repeatedly recurring, as in habitual beer drinkers, may become the cause of a permanent hypertension, which may finally result in arteriosclerosis and chronic nephritis. Strong alco- holic drinks cause a primary rise from heart stimu- lation, followed by a secondary fall when vasodilata- tion occurs. Smoking. — Smoking usually causes an elevation in blood-pressure, with the apparent paradox that many habitual smokers have a subnormal blood-pressure. The usual effect of one or two cigars, or its equiva- lent in other forms, in those accustomed to the use of the drug is a sedative action and a slight lowering of blood-pressure, while excessive smoking, during a short period of time, causes a rise of from 5 to 25 mm. Bruce Miller and Hooker, after extensive study, arrive at the conclusion that smoking is an etiologic factor in arteriosclerosis, at least in so far as the effect of circulating toxic substances affect the enlarg- ment of the vessel walls. Permissible Variations. — From the foregoing it would seem that any study of blood-pressure must have its value greatly reduced by so many modifying factors, but careful thought will show that these at most cause only slight variation, which need not obscure the issue. Experience will teach the observer to uncon- sciously include these factors in practice and enable him to arrive at the correct value of his findings by aid of them. ;iAL HypertknsiOn. 61 Determination of Pathologic Blood- Pressure Abnormal blood-pressure may be either a1)ove or below the normal level, as compared to the normal average pressure and its variations. Blood-pressure should only be designated abnormal after careful study and repeated tests, unless the change is so marked as to be beyond question. A single reading slightly above or below the normal boundaries may be occasioned by some accidental or peculiar incident, and should therefore not be taken too seriously and should never be assigned to an im- portant role in diagnosis until its persistence has been demonstrated on at least two occasions. Neither should one expect to find the same pressure, in any case, at all times. Never lose sight of the pos- sible causes of normal variation. These normal varia- tions may occur in a very short space of time, and should not, as in at least one instance known to the author, condemn the instrument, showing such varia- tion, as inaccurate. Remember also that your unfa- miliarity with a new type of instrument may cause you to neglect some detail which will invalidate your results. Study your instrument, read your instructions and he sure of our technic. Arterial Hypertension. — For a proper understanding of the treatment of the various conditions associated with which the arterial pressure is above normal, it must primarily be recognized that if the pressure is high there must be some underlying cause for the abnormality. Such cases can, as a rule, be divided into 62 Causes of High Pressure. three groups : mechanical, nervous and toxic. The most common mechanical cause is arteriosclerosis, and yet there may be pipe-stem arteries with normal pressure. The reflex nerve irritation of a peritonitis or a fright may cause a sharp rise in pulse tension, but in shock the blood-pressure falls. The cause of hypertension, which is probably the most widespread and the most frequent, is intoxication. It is generally considered that it is the irritation from poisons retained by the kidneys and not the mechanical obstruction, which sends the blood-pressure up in nephritis. Continuous high pressure is seen in certain forms of NEPHRITIS. Thus, in primary acute Bright's disease and in nephritis secondary to scarlet fever there is practically always a marked rise in arterial pressure. A rise amounting to more than 50 mm. Hg. has been observed within 48 hours of the onset of an acute nephritis. Elevated pressure is also found in begin- ning ARTERIOSCLEROSIS of the first part of the aorta and of the splanchnic vessels. In dealing with the elevation of pressure, which is the result of the action of drugs or of toxic agents, it is important to bear in mind that the amount of the substance and its concentration, its potency as well as the duration of its action will determine the amount of elevation, the duration and the permanence of the effect. Arterial Hjrpotension. — This term is applied to cases presenting a more or less continuous blood-pressure below the normal estimated pressure. A pathologic depression in blood-pressure may be caused by the depressing influence of circulating toxins acting Extreme Low Pressures. 63 either upon the heart hlood-vesscls or controHing ner- vous mechanism or to sudden withdrawal of a large volume of blood from the circulation, as in iirmor- RiiAGE, after venesection, copious diaphoresis, diar- rhea, or in shock. The lowest blood-pressure compatible with life has been reported by Neu to be from 40 to 45 millimeters of mercury, and this only occurred with subnormal temperature in the moribund state. He has seen re- covery after a fall in pressure as low as 50 milli- meters. In general, it may be said that lowered blood-pres- sure is of little significance except after hemorrhage or during surgical shock. Here the great and sudden reduction in pressure may be sufficient to immediately endanger life. It is noted that a moderate and progressive fall in pressure occurs in most progressive and prolonged fevers, as in typhoid fever. When due to such a cause, the depression is rapidly overcome and disap- pears as convalescence is established. Widespread dilatation of the vessels and conse- quent lowering of blood-pressure has been noted in the last stages of arteriosclerosis. Arterial dilatation and lowering of blood-pressure may result from general loss of arterial tone. Thus, if the splanchnic vessels become widely dilated and filled with blood, the other arteries are insufficiently filled (there is insufficient blood in the body to prop- erly fill the arteries if they are all widely dilated) (see page 85), and the pulse becomes soft, the tem- perature falls and syncope finally ensues. CHAPTER V. PRACTICAL APPLICATION OF CLINICAL DATA. I CONDITIONS ACCOMPANIED BY HIGH PRESSURE. II CONDITIONS ACCOMPANIED BY BUT SLIGHT PRESSURE CHANGE. Ill CONDITIONS ACCOMPANIED BY LOW PRESSURE. I High Blood-Pressure as a Symptom ... 65 Arteriosclerosis ....... 66 Blood-Pressure Findings in ... 67 Angina Pectoris 68 Blood-Pressure Findings in . . . 68 Acute Nephritis . . . . . 68 Effect on Blood-Pressure .... 68 In Children 69 Chronic Nephritis 69 Blood-Pressure Changes in ... 70 Signs of Kidney Failure .... 70 Uremia 70 Chronic Parenchymatous Nephritis 70 Valvular Disease of the Heart 71 Aortic Regurgitation . . . : 72 Blood-Pressure Changes in . . . 72 Disease of the Heart Muscle . Acute Endocarditis Chronic Myocarditis Blood-Pressure Changes in Functional Tests Schapiro's Test Graupner's Test Effect of Altitude in Heart Cases Eclampsia Cerebral Hemorrhage . Apoplexy and Cerebral Thrombosis Migrain .... Chronic Lead Poisoning Disease of the Eye Arteriosclerosis Ocular Hemorrhage . Inasphyxia .... Syphilis of the Heart and Blood-Vessels II Asthma Cardiac Asthma Chronic Bronchitis Neuralgia Neurasthenia Obesity Effect of Edema Acute Insanity Rheumatism Exophthalmic Goiter Infectious Diseases Typhoid Fever . Pneumonia Injection of Salvarsan Epilepsy III Varieties of Hypotension Terminal Hypotension Essential Hypotension Primary Hypotension Relative Hypotension Diabetes .... Cardiac Dilatation Shock and Collapse Hemorrhage External Hemorrhage Internal Hemorrhage Cerebral Embolism Jaundice Pulmonary Tuberculosis Effect of Altitude on Pressure Anemia Chlorosis Cholera Alcoholic Delirium CHAPTER V. PRACTICAL APPLICATION OF CLINICAL DATA IN EVERY-DAY PRACTICE. As already stated, the relation of blood-pressure in disease, compared to the estimated normal in health, may be variable (slightly above or below), may tend to hypotension or may show high pressure. The ar- rangement of the various conditions treated in the following pages is entirely arbitrary, being based on a plan which renders the material most readily acces- sible and easily obtainable for immediate reference. High Blood-Pressure Is a Symptom^ Not a Disease. — It is present in a number of common pathologic con- ditions, and when found, aids greatly in explaining certain phenomena connected with the heart, blood- vessels and kidneys. The state of the blood-pressure often furnishes the one important clue which leads to correct diagnosis or directs the attention to an alto- gether unsuspected complication. For example, a case of pneumonia is related in which all was progressing satisfactorily until one day the patient did not seem to be as well as the state of his disease would warrant. A blood-pressure test, made by a consultant who had been called, demon- strated an abnormally high blood-pressure. The urine was then examined and evidence sufficient to establish the presence of a complicating nephritis was found. 65 (^ Arteriosclerosis. At the present time certain diseased conditions are well recognized as being productive of or usually ac- companied by an elevation in blood-pressure. The two almost classical high blood-pressure conditions are arteriosclerosis and acute and chronic nephritis. Other conditions in which a high pressure is often found are chronic myocarditis, the complications of arteriosclerosis, as angina pectoris and apoplexy. Also uremia, the toxemia of pregnancy, lead poisoning, peritonitis and cerebrospinal meningitis. Conditions in Which High Blood-Pressure is a Prominent Symptom. Arteriosclerosis, as the term is here employed, implies a condition of generalized chronic hyperplastic involvement of the coats of the arteries. In this con- dition we find a permanently elevated blood-pressure, the degree of which is dependent upon the extent of the involvement present. The wider the extent and the greater rigidity of the vessels the higher will the systolic pressure be. This pressure rtiay reach 300 mm. The average case will be found to run in the neighborhood of 200 mm. Owing to the lack of elasticity, the mechanics of the circulation are so deranged that the diastolic pressure will be found disproportionately low, with corresponding greater increase in pulse pressure. It is not uncommon to find a pulse pressure of 100 or miore. The reduction in the ratio of pulse pressure to systolic pressure, under treatment, is a valuable sign. It must be remembered, however, as has been pointed out by Rudolph, that the blood-pressure in arteriosclerosis is not always Causes of Artkriosclekosis. 67 high, especially when the arterial involvement is localized, as in the superficial vessels, also that very high blood-pressnre may be net as a result of arte- riosclerosis, in the presence of apparently soft super- ficial vessels, when the larger trunks, such as the splanchnic area, is affected. Sir Clifford Albutt divided the cases of high pres- sure related to arterial changes into three classes : First — Hypertension cases. Second — Those of toxic or infective origin. Third — Involutionary or true sclerotic cases. In the first class the elevated blood-pressure pro- ceeds and produces the arterial change, while in the third the pressure is the direct result of the disease. As a rule, the degree of elevation in pressure will indicate the extent of arteriosclerotic involvement, the presence of a complicating nephritis, myocarditis or an aortic regurgitation will tend to further elevate the blood-pressure. The terminal stage of a long- standing arteriosclerosis, even when complicated by other conditions causing high-blood pressure, is usual- ly marked by a falling and finally a subnormal blood- pressure. The blood-pressure test in cases of arteriosclerosis, besides being of great value in effecting the proper diagnosis, is also of marked assistance in following the effect of treatment and in forecasting the future. But of greater value even than the systolic pressure is the diastolic, which should be estimated in order to determine the pulse pressure, which is the truest indi- cation of the amount and severity of heart overwork, which, after all, is the determining factor in the case. 68 Angina Pectoris — Acute Nephritis. Angina Pectoris. — This is usually a syndrome, de- veloping in the course of a case of general arterio- sclerosis, and denotes involvement of the coronary arteries in the arteriosclerotic process. The blood- pressure rises just before and remains high during the paroxysm of pain, usually subsiding shortly there- after. The rise may amount to 50 mm., and there may be little or no elevation in blood-pressure during the interval. The reduction of high blood-pressure in those with a tendency to angina is often most suc- cessful in preventing subsequent attacks. The blood-pressure test sometimes serves as a val- uable aid in differentiating true angina from those conditions best termed anginoid, which are so often met and which frequently cause the physician much trouble and embarrassment in estimating their true significance. It is believed by Janeway and others that, given a case presenting the symptom complex of angina, in which the blood-pressure is continually ab- normally high, it will probably be one of true angina; while unfortunately the converse is not true, as cases of demonstrated true angina have been met in which the pulse is small, easily compressible and the tension low. Acute Nephritis. — A sharp rise in blood-pressure is usually the first sign of the onset of an acute nephritis. This complication, developing in the course of an acute infection, may be discovered by a routine study of the blood-pressure, where the rise may antedate the development of the usual signs, including altera- tions in the urine by as much as 24 hours. This fact should be a most emphatic indication of the value and importance of daily blood-pressure readings during the course of all infections, particularly scarlet fever. Chronic Nephritis. 69 Acute Nephritis in Children. — Lennox Gordon reports 9 cases, in all of which the blood-pressure was raised, in some cases to a very high level, and in them this was of very marked diagnostic value. He believes that by means of the sphygmomanometer only could the change in blood-pressure in children be ascertained to any degree of certainty. Chronic Nephritis. — ^A gradually developing chronic nephritis is shown by a gradually rising blood-pres- sure, accom.panied by the usual alterations found in the urine. A high blood-pressure reading, of more than 200 mm. found during the examination of any patient should place one on guard and start a careful examination for other signs of this condition. The blood-pressure in chronic nephritis is persist- ently elevated, and may be extremely high. Pressures of over 300 mm. have been reported. A sudden further rise in pressure occurring during the course of a chronic nephritis is often a most valuable warn- ing, as a sign indicative of an impending uremic attack. This rise, if noted early, furnishes the basis for immediate action, to control the pressure by pow- erful eliminative measures in order to avert, if pos- sible, the uremic attack. Such treatment if often very successful. J. Fischer, in the Duch. Arch. f. klin. Med., 1913, after a study of 550 patients running a continuous high blood-pressure, emphasizes the importance of being on the lookout for permanent kidney lesions in patients even with a moderately high pressure, as in 62% of his series with pressure above 140 there were signs of permanent kidney lesions, while 80% had chronic kidney change, and in some of these there 70 Uremia. was no clinical evidence of kidney trouble, excepting continuous high blood-pressure. A study of blood-pressure in cases showing tran- sient or persistent traces of albumen in the urine will often serve to demonstrate the cause and seriousness of this condition, because it is well known that high blood-pressure is always an accompaniment of chronic nephritis, and also because it is believed that a normal blood-pressure, even with albumen in the urine, places the albumen in a class with minor and not serious affections. Unexplained persistent high blood-pres- sure, even when albumen cannot be demonstrated in the urine, furnishes ample grounds for strongly sus- pecting chronic changes in the kidneys. After a long or short period of sustained high pres- sure in chronic nephritis, the pressure will begin to fall, and after a long period of time fail to raise to its highest level. Experience teaches that this is a danger signal that the reserve of the heart and circulation has been exhausted and that a further fall may be expected, and that, sooner or later, this will result in retarded kidney activity and all that this implies. Chronic Parenchymatous Nephritis. — The few avail- able reports on blood-pressure in this disease fail to show" that a high blood-pressure is an accompaniment of it or that the blood-pressure bears any relation to the duration or severity of the kidney inflammation. Uremia. — This often fatal complication of nephritis is accompanied by a sudden and often sharp rise in an already greatly elevated blood-pressure, or else an already high pressure begins to mount upward to a dangerously high level. These changes in blood-pres- sure may, by careful observation with the sphygmo- Blood-Pressukk in Valvular Dlsease. 71 manometer, l)e noted suflicicntly early to allow time for the institution of preventive measures, directed toward the relief of toxemia, by increasinj^ elimina- tion. The l)lood-])rcssure durin<( an uremic attack may be far above v300 mm. Actually how high has not been recorded, because before the development of the Faught Clinical Sphygmomanometer no instru- ment was capable of recording pressures above 300 mm. In patients who are seen in emergency and are found profoundly unconscious, the sphygmomanomet- er will often be the means of separating the coma of uremia with high blood-pressure from coma of other origin. In Valvular Lesions. — In the study of the valvular disease of the heart the results do not seem to have special bearing upon the primary condition (defective valve) except in cases of aortic regurgitation. This is in part due to the usual complicated nature of the condition, which often includes arterial and myocar- dial changes and involvement of the kidneys. The chief value of the sphygmomanometer in the study of heart conditions applies to the condition of the myocardium, to a demonstration of the etTect of therapeutic measures and as a guide in prognosis and in the general management of cases. With it we are able to determine with considerable accuracy the bene- fit derived from the drugs and other measures em- ployed. In this we may guard against insufficient or improper treatment and also against the over-use of these same measures by demonstrating the therapeuti- cally efficient dose and the proper interval of its exhi- bition. 72 Aortic Regurgitation, Aortic Regurgitation. — The blood-pressure test may be sufficient to establish a diagnosis in pure aortic re- gurgitation, the great pulse pressure occurring in this condition being almost pathognomonic. Referring to the physics of the circulation, we find that in aortic regurgitation the left venticle is called upon to deliver an abnormally large volume of blood into the aorta to supply the demands of the circulation. This is because the heart is required not only to furnish sufficient blood for the needs of the body, but must also inject into the aorta at each systole enough surplus to com- pensate for the regurgitation of a large volume of blood into the left ventricle during diastole. The natural result of the sudden injection of this large amount of blood into the arterial system will be to cause a sudden and great rise in systolic blood-pres- sure (immediately succeeding systole the blood dis- perses in two directions, forward through the capil- laries and backward into the ventricle, producing the phenomenon of the water-hammer pulse). Thus the pressure rapidly falls and the diastolic pressure is abnormally low. The combined result of this HIGH SYSTOLIC AND LOW DIASTOLIC PRESSURE IS A GREAT PULSE PRESSURE. This may amount to 100 mm. or more. In the presence of moderate or high-grade gener- alized arteriosclerosis, this phenomenon is further ac- centuated because the lack of normal elasticity in the arterial system tends to reduce the diastolic pressure to zero. Occasionally, in cases of mitral stenosis, the blood- pressure may tend toward a low level, but this is Myocardial Disease. 7?) usually more than compensated for l)y the accompany- ing changes in the heart muscle and larger arteries. Acute Endocarditis. — In a few cases of acute endo- carditis that have been reported, it has been found that the endo-cardial condition itself has little, if any, efifect on systolic blood-pressure. Myorcardial Degeneration. — Many cases of chronic myocarditis have sufficiently marked signs to be easy of diagnosis ; in other cases of the cardiovascular renal type diagnosis may be extremely difficult. Here it is most important that the general practitioner should be able to recognize these changes sufficiently early to be able to institute treatment with good chance of arresting the progress of the disease indefi- nitely or as long as the patient adheres to his new regime. These cases usually occur in middle life, and may be far advanced before discovered, as they often are, accidentally, in the course of examinations for life insurance. The difficulty of correctly estimating them is great, for, while we may be morally certain of the existence of heart weakness, we may not be able to prove the existence of myocarditis, and often erroneously class them as nervous or functional. In the physical examination the state of the super- ficial vessels, together with the pulse rate and particu- larly the reaction of the heart to posture and exercise as determined by the sphygmomanometer, is all-im- portant. This latter may be determined by the fol- lowing tests : Functional Tests. — Moderate exertion raises pressure in normal hearts, and this rise is sustained during it if not unduly severe or prolonged. In weakened heart muscles from any cause a primary rise may 74 Functional TEsts. occur, but is quickly followed by a fall; in the worst a fall occurs from the first Schapiro's Test. — This is based upon the alteration in pulse rate occurring in normal individuals on change of posture from the standing to the recum- bent. Normally the number of pulse beats per minute is from 7 to 10 less in the recumbent position; but when chronic myocarditis develops, this difference tends to disappear, so that in seriously weakened hearts the pulse may be as rapid in the recumbent as in the sitting posture. Graupner's Test. — This is based upon the physiologic fact that a given amount of exercise, such as ten bend- ing movements or running up a flight of stairs, causes an acceleration in the pulse rate and an elevation in blood-pressure. But the latter does not appear coin- cidently with the former; or if, as in some cases, the pressure does rise first, it fails to rise again after the pulse has returned to normal. It is this secondary rise which indicates a good heart muscle. A not too seriously affected heart may show a rise in blood- pressure immediately after the exertion, but with the slowing of the pulse the pressure will be found to have fallen to a level lower than before the experi- ment. The sphygmomanometer is required for an accurate demonstration of these changes in pressure, which may be recorded in definite units of measure for future reference and comparison. It is not advisable to apply this test to pa- tients WITH excessively HIGH BLOOD-PRESSURE, IN THOSE OF APOPLECTIC TENDENCY OR IN THOSE WITH HIGH-GRADE ARTERIOSCLEROSIS. The tcst is uusafc in those with a systolic pressure of 200 millimeters or Altitude on Heart Cases. 75 over. In such cases tliere is danger of ocular or cerebral hemorrhage or acute dilatation of heart. The test will be difficult, if not impossible, of appli- cation in women unless all tight clothing is removed. Valvular disease is not necessarily a contraindica- tion to this test, as the condition of the myocardium seems to be the only important factor, except in aortic regurgitation with high pressure, so that the presence of valvular lesions need not detract from the value of the information obtained by this test. The Effect of Altitude on Cardiac Cases. — It is import- ant to consider the condition of the patient in refer- ence to the circulation before advocating residence in high altitudes. In young convalescents, in the absence of organic heart affections, even in the presence of the moycardial weakness due to recent acute or chronic infections, moderately high altitudes are usually beneficial. In the arteriosclerotic without valvular lesions, the cardiac reserve is often much exhausted, and there- fore sudden changes in altitude may result in serious consequences through added sudden strain on the circulation, due to changes in peripheral resistance. High altitudes may be extremely dangerous. In the true cardiac case with organic lesion, high altitudes are often dangerous because, even when compensa- tion is fairly well established, the balance in favor of the heart is very slight, and here again the changes in circulatory equilibrium, by causing slight increased strain, may again produce decompensation. Eclampsia. — Blood-pressure is usually high, but may occasionally, in very severe cases, be low. Pressures have been recorded as being over 320 mm. See also page 92. l(i Cerebral Hemorrhage. Cerebral Hemorrhage. — The occurrence of a cerebral hemorrhage is usually preceded by a long period of high blood-pressure, accompanying a nephritis, {an arteriosclerosis, or both. It is not the degree of per- manent elevation so much as a sudden rise in an already high blood-pressure that causes the vessel to rupture. Thus cases of arteriosclerosis, showing an average systolic blood-pressure of 225 mm., have, following a rise of 30 or 40 mm. more, suffered an apoplexy. On the other hand, the author has seen more than one case of chronic nephritis registering pressures fre- quently above 250 mm., occasionally over 300 — one case almost 310 — without the occurrence of anything more serious than a mild cerebral edema of very transitory character. The highest blood-pressure readings occur in apoplexy cerebral thrombosis, depressed fracture, intracranial hemorrhage and in rapid growing cerebral tumors. Pressure up to 400 mm. has been recorded in these cases, while the diastolic pressure is extremely low and the pulse rate slow. The value of this high pressure in these condi- tions is probably directed toward maintaining a fair blood supply against the greatly increased intracranial tension. This emphasizes the importance of recent teaching that one should not bleed or make other effort to lower the pressure in these cases, but to operate immediately or else administer atropine in large doses to keep the pressure up, and await developments. Migrain. — Migrain is usually accompanied by hyper- tension, which may, according to Russell, be localized and confined to the arteries upon one side of the body, particularly those of the head. The discovery of Blood-Pressure in Diseases of Eye. 11 hypertension in any case, tlie suljjcct of periodic attacks of hemicrania, will furnish reasonable f^round for therapeutic endeavors, as it has been shown that the reduction of hypertension by eliminative measures in these cases is often successful in preventinf]^, or at least reducino^, the severity of the attacks. Chronic Lead Poisoning. — Chronic lead poisoninj^, accompanied by attacks of coHc, is usually attended with an increase in blood-pressure. Temporary ele- vations of 30 or 40 mm. have been recorded. The fact may be of value in differentiating colic due to lead from renal and biliary colic in which the blood- pressure is low. Eye Diseases. — It has long been recognized that high blood-pressure is an important factor in several eye conditions, but not until recently has this knowledge been put to practical clinical use by the ophthalmic surgeon. Arteriosclerotic changes in the retinal vessels will immediately suggest the necessity of a blood-pressure test. The finding with the sphygmomanometer will reveal the significance of the eye condition by demon- strating the degree of general arteriosclerosis present. This knowledge may be put to practical use by insti- tuting measures directed toward relieving the high pressure and by modifying the individual's life and habits in an effort to arrest the arteriosclerotic process. Ocular Hemorrhage. — Fox and Batroft" report in detail a study of one hundred consecutive cases of ocular hemorrhage in which the blood-pressure test was employed. In 80 per cent, of these cases hyper- tension was encountered. 40 per cent of the cases of retinal hemorrhage were accompanied by chronic inter- 78 Effect of Syphilis on Blood- Pressure. stitial nephritis. Arteriosclerosis was present also in 27 per cent, and parenchymatous nephritis in 13 per cent. Asphyxia. — The effect on the cerebral centers in this condition, no matter what its cause, is usually a marked rise in blood-pressure. This is seen in nitrous-oxide anesthesia. The condition is also met in asphyxia and cyanosis from other causes, such as obstruction to the larynx, diseases of lungs, etc. Sjrphilis of the Heart and Blood-Vessels. — The usual diagnosis of syphilis of the heart and blood-vessels must be based on the same grounds which serve us in diagnosing other syphilitic manifestations. As the syphilitic heart and blood-vessels show clinically nothing absolutely characteristic, nothing which is not found in other diseases, we should be suspicious of syphilis in any patient with arterial involvement before judging it to be senile arterio- sclerosis, especially when the process includes the aortic valves and when incompency develops grad- ually rather than suddenly, and when it is not accom- panied by fever or other signs of acute endarteritis. The Wasserman and Leutin tests will show syphilis to be present much more often in such diseases than is usually believed. The relative rise in pressure will, of course, depend largely upon the extent of the involvement or whether or not the arterial tree is included in the process. Ri.ood-Prkssukk in Am II ma. Diseases in Which the Blood-I'kessure is not Greatly Affected, But in Which Information Obtained by the Sphygmomanometer is of Value. In asthma the value of the blood-pressure reading will depend upon the variety of this disease encount- ered. In cardiac asthma the pressure is, as a rule, low. The finding of low blood-pressure accompanying a case of cardiac asthma is an indication for support of the heart and circulation ; improved heart tone and a better circulatory equilibrium being followed by a less- ening in frequency and lengthening of the interval between attacks. In asthmatic attacks of other origin the blood-pres- sure is variable, and unless markedly altered from the normal, is of little significance. Chronic Bronchitis. — The general condition of the patient will influence the blood-pressure finding. The occurrence of hypotension in chronic bronchitis will suggest the advisability of tonic measures directed toward improving cardiac and blood-vessel tone. Neuralgia. — This condition is usually accompanied by a reduction in pressure, although this may not be sufficient in degree to be noticeable. This lowering of blood-pressure is in all probability due to the influence of pain upon the vasomotor system. Neurasthenia is believed to be accompanied by a hypotension. This appears to be apart of the general loss of tone present in this disease and may be a rough indication of the severity of the exhaustion state. 80 Blooo-Pressure in Insanity. It is well known that, in active men who are approaching middle life, the insidious development of arteriosclerosis or chronic nephritis, or both, fre- quently shows itself in a symptom-complex compris- ing irritability, lack of concentration, a feeling of lost confidence in one's self, sleeplessness, general fatigue, etc., a combination of symptoms often occurring in true neurasthenia. In these cases a study of blood- pressure is most important as a guide to diagnosis, a heightened blood-pressure often being the one sign by which the true diagnosis is reached. Obesity. — Obesity per se has no modifying influence on blood-pressure. The relative level of blood-pres- sure found in any case of obesity does not depend on the size of the arm to which the cuff is applied, and will be normal for the age of the individual examined, unless the excessive fatness is in the relation of cause or effect with some anatomic or pathologic change, in the heart, blood-vessels or kidneys. The disturbing effect of edema in cases of obesity should be remembered, as the presence of edema in the arm to which the cuff is applied when taking blood-pressure will so interfere with the transmission of pressure as to render the observation valueless. In insanity (mania), the mental state of the case at the time of examination will largely determine the pressure level, which, if not normal, may be either slightly above or below it. The characteristic effect of blood-pressure altering complications will be shown here as in normal individuals, and here, as in any case, blood-pressure records are valuable, in that they may early detect the onset of complicating affections and may aid the defendant in his efforts to prevent their development. Blood-Pressure in Exophthalmic Goiter. 81 Rheumatism has been singled out from the many acute infections as a condition for special l)lood-pres- sure study. The result of these studies simply shows that rheumatism, like any other acute infection, is accompanied by an elevation in pressure ( 10 to 20 mm.) during the period of invasion, that in severe cases it may fall to a marked hypotension and that convalescence is marked by a gradual return to nor- mal unless influenced by the development of compli- cations. Exopthalmic Goiter. — The involvement of the cardiac and vasomotor centres in this disease has been shown to be accompanied by an irregular effect upon the blood-pressure, the stage of the disease and the severity of the symptoms determining the result. Thus some observers have reported an upward tendency and some a downward. The study of blood-pressure may be of value in this disease, by showing the rela- tion of a tachycardia to a hypotension, thus directing the treatment upon more rational lines. The cessation of menstruation at the climacteric, while physiologic in nature, is more often than not pathologic in character, particularly that part of the phenomenon involving the nervous system. In this state, as in all profound nervous disturbances where the cardiac and vasomotor activities are involved, we have more or less frequent disturbances of vasomotor character, as shown by palpitation, tachycardia and flushings. These are often accompanied by altera- tions in blood-pressure, whose chief characteristic is a sudden variation in the pressure curve from normal to hypo- or hypertension and back again. 82 Blood-Pressure in Infectious Diseases. Infectious Diseases. — In diphtheria, scarlet fever and infectious diseases in general the blood-pressure shows some variation, which is mainly dependent upon the period of the disease. Thus it is found that pressure has a tendency to rise slightly (5 to 15 mm.) during the period of invasion, and then to fall gradu- ally during the further progress of the disease to a hypotension, to rise again toward normal as conva- lescence is established. The occurrence of compli- cations will be shown by a change in blood-pressure which fails to conform to this rule. Thus a compli- cating nephritis will be shown by an early and sharp rise in blood-pressure. This may measure more than 50 mm. in twenty-four hours. Typhoid Fever. — A slight primary rise may be noted, but this is a disease of low blood-pressure, in which the readings are not infrequently all below 100 mm. A markedly depressed blood-pressure during the attack is a valuable indication for the need of stimulating treatment. A fall in pressure occurring suddenly, especially after the second week, is usually indicative of hemorrhage. A short, sharp rise is often a valu- able sign, pointing to perforation or peritonitis from a deep ulcer. Pneumonia. — Gundrum and Johnson (California State Journal of Medicine, Vol. 10) report studies of a series of thirty cases of pneumonia in which the blood pressure and pulse rate were taken simulta- neously. Twenty-six were lobar pneumonia. The patients were all adult males, 20 were alcoholics. The mortality was 30%. The blood-pressures on admission show a great variation, ranging from 65 to 122 mm., while the KlTK^T OK Sa/.VARSA.V. 8i pulse ranged from 68 to 148. According to Gibson's rule on admission, 18 patients were in good condition and 12 in poor. Of the 18, 17 recovered (94%) and one died (6%). Of the 12 patients in poor condition, 3 recovered (257o) and 9 died (75%). This study emphasized most powerfully the accu- racy of the observations made by Gibson several years ago, and make it imperative that every phy- sician should routinely employ the blood-pressure test in all cases of pneumonia, not only to effect a better prognosis, but to guard against the development of danger symptoms. Injections of Salvarsan and Neo-Salvarsan. — During the intravenous injections of these substances col- lapse not infrequently occurs without a moment's warning. It has been suggested by some observers that frequent, rapid blood-pressure tests made dur- ing this procedure would be a valuable guide as to the safe progress of the operation, and also that this test may be used as a guide to the amount and rapid- ity with which the drugs may be administered. Epilepsy. — Owing to the increased muscular activ- ity occurring during an attack of apoplexy, the blood- pressure shows a rapid rise during the violent stage, and a rapid fall usually to the point of original level, as the paroxysm subsides and coma develops. In a patient seen during coma, where the patient's his- tory cannot be obtained, this fact may be of aid in differentiating the coma of epilepsy from that caused by uremia or apoplexy, in which high pressure is the rule. 84 Low Pressure Cases. Pathologic Conditions in Which the Blood- Pressure IS Usually Below Normal. In discussing low blood-pressure we must classify several varieties of this condition in order to appre- ciate the underlying factors leading up to and result- ing from this condition. They are as follows : — Terminal hypotension means the gradual lowering of blood-pressure which occurs during the last hours or days of life, and is the direct result of a gradually failing cardiovascular mechanism. Essential hypotension is met in cases in which the cause of the low pressure cannot be explained. Found occasionally in members of tuberculous families, in whom no definite signs of the disease are shown. It is a particularly common condition in those cases which are now occasionally recognized as having con- genitally small hearts and narrow arteries. Primary or True Hypotension is defined by Bishop as being present in those cases where the blood-pres- sure mechanism has failed, but where there has been no previous over-demand for pressure. The term Relative Hypotension is applied to the condition of blood-pressure occurring in individuals who have had a distinctively permanent elevation in blood-pressure, but in whom the pressure at the time of examination is found to be normal or slightly above. These cases are most significant, as it is in them that we meet most serious and distressing symp- toms pointing to circulatory failure, yet in whom the pressure is still above the estimated normal level. This relative hypotension is sometimes hard to estab- lish, but if once determined and satisfactorily ex- Dilatation of Hi:ai yi 1. ' 4 i 70 *. ( 65 ^ 60 Hi BBi ^H ^H Hi ^1 Hi ^1 ^1 IHi Fig. 26 — Taken from a case working of Gibson's rule. which shows graphically the 108 Ether — Chloroform — Ethyl Chloride. Usual Effect of Different Anesthetics on Blood-Pressure. Ether alone causes a moderate rise in blood-pressure during the early period of its administration. Strug- gling causes a further rise, together with an accelera- tion in pulse rate. These changes rapidly subside as the stage of anesthesia is reached, so that, under ordi- nary circumstances, the pulse and blood-pressure remain at or about the same levels on the chart as were noted prior to the removal of the case to the operating room. Dangerous symptoms occurring during the course of operation will usually early be shown by changes in pulse rate and blood-pressure; the blood-pressure falling and the pulse rate rising, so that this change developing during anesthesia will indicate to the sur- geon the advisability of haste in completing the opera- tion or the necessity of dividing the operation into two stages. Chloroform is a dangerous anesthetic under all cir- cumstances and its use should always be attended with great care. It has been demonstrated that blood-pres- sure falls gradually from the very beginning of the administration. This fall may occur during the first few minutes and be so great as to endanger life. When this anesthetic is used, the blood-pressure test should be continuously employed, and every .effort made to avoid a dangerous fall in blood-pressure. Ethyl Chloride. — This drug, according to the last report of the anesthesia commission of A. M. A., is a very safe anesthetic, and observations on blood-pres- sure seem to bear this out. There is a tendency to a Spinal Anesthesia — Local Anesthesia. 109 fallinj:^ pressure \\Iu\li, liowexcr, is not j^rcat, ancl which is easily controlled hy the admission of suffi- cient air. Spinal Anesthesia. — According to Colcord, in surgi- cal anesthesia there is a rise at first, due in part to mental excitement, puncture, drawing off of fluid and to the injection of the solution. This lasts from 15 to 20 minutes ; then the pressure falls to near the normal line and the chart shows remarkably few excursions above or below during the operation. According to Gushing, if the anesthesia extends too high into the dorsal cord, paralysis of the efferent nerves to the splanchnic area may be induced, causing a dangerous fall in blood-pressure. Local Anesthesia. — In local anesthesia several fac- tors influence blood-pressure. These are : 1. Cocaine itself produces a rise in blood-pressure. 2. The mental excitement, always a variable fac- tor, may produce a rise. 3. Any pain from injury to nerves, not anes- thetized, will cause a rise. 4. Injury to nerves completely anesthetized will cause no change in blood-pressure. Operative Effect on Blood-pressure. — The surgeon should be in possession of the facts concerning the influence of operative procedures on blood-pressure. Thus, when the skin is incised, there is usually an abrupt fall in blood-pressure, transitory in nature. The same lowering is noted when the peritoneum is incised and also when viscera are pulled upon or exposed to the drying influence of air. Two procedures, there- fore, to be studiously avoided, or, if necessary, care- 110 Surgical Procedures. ful watch should be made for the occurrence of shock, with the sphygmomanometer, during such procedures. Cataract Operation. — No careful surgeon ever attempts to enter an eye either in cases of glaucoma or cataract without first carefully studying the blood- pressure. The indications in the presence of a high blood-pressure are first to reduce the pressure and then operate. This method will save a large percen- tage of eyes which were formerly lost by intraocular hemorrhage, a complication the direct result of a sud- den reduction of tension in an eye, having diseased blood-vessels, which were unable to withstand the sudden loss of support following the scleral incision. CHAPTER VIIL THERAPEUTICS INDICATED BY BLOOD-PRESSURE CHANGES Therapeutic Indications Of Hypotension Of Hypertension With Albuminuria In Aortic Aneurism In Acute Bright's Disease Treatment of High Pressures When Not to Treat It Effect of Nitrites . Vapor Baths Venesection Osteopathic Measures 111 111 111 112 112 112 112 113 113 113 113 114 Pilling;-Faug-ht Pocket Sphyg;momanometer in Use. CHAPTER VIII THERAPEUTICS The study of bloocl-i)rcssurc frequently furnishes the key to proper treatment in a number of diseases ; it also furnishes a reliable guide as to the efficiency of the measures employed, as well as the time during which treatment should be continued. It is not within the scope of this little work to more than touch upon a few of the most important points in the relation of blood-pressure to the management of disease. Hypotension. — The general symptoms accompanying diminished blood-pressure indicate in no uncertain manner the necessity of tonic treatment. In cases of emergency, w4th suddenly falling pressure and evi- dence of collapse, adrenalin intravenously or hypoder- mically is indicated. For the sudden drop in blood-pressure occurring in advanced arteriosclerosis, digitalis is indicated, pro- vided there is no evidence of marked myocardial degeneration, in which event strychnin is the safer drug to use. In lowered blood-pressure from hemorrhage or pro- fuse and prolonged diarrhea, the pressure is the best indicator of the amount and the frequency for the use of saline infusion or the Murphy treatment. Hypertension.— High pressure in the apoplectically inclined calls for active and continued pressure-reduc- ing treatment. Among the drugs which are gener- 111 112 Treatment of High Pressure. ally depended upon to accomplish this change are the nitrites, of which a freshly prepared solution of Kodium nitrite will be found the most serviceable, being easy of administration and prolonged in action. In the treatment of aortic aneurysm with high pres- sure, the use of blood-pressure reducing agents may materially prolong life by reducing the tendency to rupture, and at the same time afford relief from the most distressing symptom — pain — by lessening the tension in the aneurysmal sac, thereby relieving the nerve irritation and the pressure upon surrounding organs or tissues. In acute Bright's, after failing to reduce the pressure by the usual measures, it may sometimes be controlled by the electric-light sweat bath. In one case a reduc- tion of from 20 to 40 millimeters was obtained, the beneficial effects lasting for many hours, so that regu- lar observation of the pressure determined the proper interval between the sweats. Albuminuria. — Albumen appears in the urine when- ever the kidneys are passively congested, and its importance, when due to this cause, is often greatly exaggerated. Albuminuria, associated with kidney disease, is nearly always accompanied with elevation in blood-pressure ; albumen, when due to other causes, is not usually so accompanied. As these two causes of albuminuria demand almost diametrically opposite treatment, their differentiation is of the utmost importance. When to Treat High Blood-pressure. — It is important to realize that the mere finding of an elevated blood- pressure is not always an indication that it should be reduced; it is always a bad rule to promiscuously institute measures to reduce pressure. This should Effect of DRUGh never be done. Blood-pressure reduction should only be attempted for a good reason, based ui)on a careful study of the case. Long continued high pressure often becomes an essential to the well-being of the indi- vidual, which, if interfered with, may so destroy the circulatory equilibrium that disaster results. The chief group of drugs employed to control and lower high blood-pressure are vasodilators. These act chiefly upon the sympathetic and vasomotor systems, cause a widening of the blood channels and a conse- quent lowering of the blood-pressure. The value of the sphygmomanometer is chiefly in demonstrating the efficiency of the measures employed in any given case. This guards the practitioner from placing too much confidence in any particular remedy, because he can readily ascertain whether he is accomplishing the desired result. This is particularly important because numerous investigators have shown that no particular drug can be depended upon to produce the same results under all conditions, even with a maximum dose. Another important function of the sphygmo- manometer in therapeutics is to determine the period of duration and action of the particular drug employed, thereby enabling the physician to intelligently manage his therapeutic measures and accomplish his purpose. The sphygmomanometer has also shown that many measures other than drugs may be relied upon to con- trol and lower high blood-pressure, often more advan- tageously. Thus, in the employment of vapor baths of various sorts, we can control the effect and deter- mine the proper time for another treatment. In venesection the amount of blood which may safely be withdrawn is best determined by noting the effect of the bleeding on blood-pressure. 114 Effect of Osteopathic Treatment. Therapeutic Effect of Osteopathic Treatment ON Blood-Pressure. J. P. Downing, A. B., D. O., has made a series of studies with the sphygmomanometer over a period of three years and has records of 300 cases. From the result of this study it is apparent that the meas- ures employed were productive of good results in certain classes of high tension cases. This seems to be particularly true of those in which there is no physical reason for the hypertension (many of the cases were studied by regular practitioners in order to exclude organic conditions before the treat- ment was applied). Here spinal treatment has a decided tendency to reduce the systolic pressure, the effects of which are usually lasting, often persisting for 24 hours or more. It is not uncommon to get a fall of from 15 to 40 mm. after a treatment occupying 15 or 20 minutes. These results are confirmed by Abrams and others, who are at the present time em- ploying methods somewhat similar to those of oste- opathy, and in which the lower cervical region is the point of therapeutic attack. It is evident also that the measures applied by osteopathy are productive of good results when applied to raising an abnormally low pressure. In 16 cases of anemia reported, the pressure ranged from 80 to 100, which, after 2^ months' treatment, with one exception, all came up and remained above 110. In 6 cases of chlorosis, in which the blood-pressure averaged 90 before treatment, four were raised to 120 and remained up, one came to 110, and only one failed to respond to trieatment. CHAPTER IX. BLOOD-PRESSURE IN LIFE INSURANCE »rtance of the Test 115 Normal Variations .... 115 Formula to Estimate Normal Pressure 116 Application of the Test . 117 In Arteriosclerosis . 117 In Chronic Nephritis 117 With Albuminuria . 117 In Over- Weights 118 In Chronic Myocarditis . 118 In Tuberculosis 118 LIFE INSURANCE The medical director of one of the largest insurance companies speaking of the Faught Pocket Sphygmomanometer writes : ''As you know we have used the Faught Sphygmomanometer for some months, and it is entirely satisfactory ; it is certainly most convenient. CHAPTER IX BLOOD-PRESSURE IN LIFE INSURANCE During the past several years a majority of life insurance companies have admitted the value of the blood-pressure test as a prognostic aid in life insur- ance examinations. At the present time most of the larger companies require the test of every applicant for life insurance. A larger number require the test of all applicants over forty years, in overweights and underweights, and in all those in whom the character of the risk has been previously questioned by any company. The chief value of this test lies in the fact that, by a study of these records in conjunction with that of the pulse, we are able to detect beginning pathologic change in the cardio-vascular system or kidneys, often before there are any definite signs in the physical examination, personal history or urine. Another good reason for the universal employment of the blood- pressure test in life insurance examinations is the fact that the apparent character of the pulse and of the vessel walls does not always convey the correct infor- mation regarding the condition of the applicant. Clini- cians have agreed that the estimation of blood-pres- sure by palpation is not satisfactory and that even the most experienced occasionally fall into grave error. Normal or Permissible Variation. — Unlike the tempera- ture, which has a fixed normal, the blood-pressure in 115 116 Blood-Pressure in Life iNSxmANCE. the normal individual is a variable factor. This is because of the complicated cardiomotor and vasomotor mechanisms. These are under sympathetic control, and are therefore affected by the varying conditions to which the body is subjected during every 24 hours. These variations result from changes in posture, exer- cise, excitement and from digestive activity. They are also dependent upon the time of day, age, sex and the physical development of the individual. Fortunately the amount of alteration in pressure caused by these varying conditions is not great, and we are therefore able to lay down a fairly definite rule which has for its object the determination of the per- missible variation in pressure in any individual of a given age. Formula to Estimate Normal Pressure. — The writer devised and published, in 1910, a formula w^hich may be used to estimate the normial systolic blood-pressure, which gives results conforming closely Avith the figures obtained from careful clinical reports. The formula is as follows: "Consider the normal average systolic blood-pressure in men at age of 20 to be 120 mm. Then add 1 mm. for every additional 2 years of life." Thus a man aged 30 should have a normal average systolic blood-pressure of 125 mm., while a man aged 60 should average 140 mm. The difference in pres- sure between men and women is approximately 10 mm., being lower in women. Clinical evidence shows that the ordinary daily variations in pressure in any individual rarely amount to more than 36 mm. If we accept this, then a varia- tion of 17, either above or below the normal average, may be allowed. Appr.TrATrffX or Tf.st. 117 Application of Test. — As a rouline measure the left arm should be employed and the cuff should be applied to the bare arm. The applicant should be in a com- fortable position, preferably sitting. Time should be allowed to permit the circulation to become quieted, and nervous individuals should bic assured of the harmlessness of the test. A single reading equal to or just above the esti- mated maximum pressure for a given individual should never be accepted as final, as this pressure may be accidental and may never again be met. Observa- tions should be repeated at a later time or upon a different day before reporting the pressure. A moderate degree of arteriosclerosis may cause an elevation in pressure but slightly above the estimated high normal; 15 or 20 mm. above this calls for further investigation, not only of the blood-pressure, but of the general physical condition of the applicant. The blood-pressure will frequently read between 160 and 180 mm. in the average case of uncompli- cated arteriosclerosis. Nephritis. — Urinalysis does not always demonstrate chronic nephritis, particularly in individuals of appar- ent normal health. On the other hand, it is said that the blood-pressure in an established case of chronic interstitial nephritis is rarely below 200 mm. In acute nephritis the blood-pressure, while above the normal, may not be that high. The finding of a high blood- pressure with a normal urine calls for repeated urinalysis. Metabolic Albuminuria. — The finding of a trace of albumen and a few hyaline casts in the urine, with a normal blood-pressure, suggests the probability that 118 Conditions Effecting Pressure. the urinary condition is not the result of kidney altera- tion, but is metabolic in character. Such a condition can readily be relieved by appropriate treatment while the case is held under advisement, and many of them will eventually obtain the amount of insurance desired. Overweights. — This group shows an unfavorable mortality in life insurance statistics, particularly of the older ages. Given an individual of modern over- weight, where the physical examination and history are favorable, the final decision is often made upon the result of the blood-pressure test; accepting them when the pressure is normal and declining them when the pressure reaches or passes the normal high limit. Chronic Myocarditis. — This is the most difficult con- dition to diagnose, especially by the insurance exami- ner, because these cases often require long study and careful observation in order to arrive at the proper rating. A history of hard physical labor, excessive brain work, alcoholism or syphilis is often significant. In the early cases the systolic pressure is not always altered, so that recourse must be had to the functional tests of Graupner and Shapiro (see page 74), and also to the estimation of the diastolic and pulse pres- sures. Incipient Tuberculosis. — Slight reduction in blood- pressure, combined with modern elevation in pulse rate, even without fever, suggests the possibility of an active pulmonary lesion. If this be combined with fever and a history of slight loss in weight, the case should be declined on this presumptive evidence. In tuberculosis the blood-pressure is usually low and the pulse pressure diminished. Blood- pRKss ukk Stkt i i o.S( oi'e. 119 PILLING-STAMP BRACELET STETHOSCOPE IMPORTANCE OF ACCURACY IN BLOOD-PRESSURE EXAMINATIONS. Of all methods of recording systolic and diastolic readings there is not one dissenting opinion among scientists that the auscultatory is the one absolutely correct method. Until the development of the Stamp Bracelet Stethoscope the labor and difficulty surround- ing accurate auscultatory observations in blood-pressure were almost insurmountable because of lack of prop- erly adjusted and sufficiently delicate apparatus. THE METHODS OF TAKING READINGS. There are probably only four recognized methods of making readings and they are : 1. Visible. 2. Palpatory. 3. Auscultatory. 4. Diastolic Indicators. Of these the most accurate for both systolic and diastolic readings is the auscultatory method. Prob- 120 Auscultatory Blood-Pressure. ably there is a slight difference between diastolics with this method and the other three, but in spite of this, it is the most satisfactory in every way. It is, of course, for purposes of comparison, always •important to use the same method in a series of obser- vations, whether on individuals or groups. Accurate records of the blood-pressure with any sphygmomanometer can be obtained only by means of the auscultatory method. By this method it is only necessary to distinguish between the presence and absence of certain plainly audible sounds, which are not affected to any extent by varying conditions, such as size of arm, exact location of vessel, or the personal equation of the examiner. All large Insurance Companies now recognize not only the importance of a systolic, but also of a diastolic determination. Ofttimes we find that a relatively high systolic is only nature's effort to compensate and that there is no danger from it whatever. This observation can be determined only by the accurate readings made possible by using the Stamp Bracelet. NORMAL RELATION OF SYSTOLIC TO DIASTOLIC PRESSURE. There exists a relationship between the systolic and diastolic pressures and their resultant pulse pressure that has been generally accepted as follows : Where 120-80-40 may represent the systolic, diastolic and pulse pressure, respectively, we might also have 200- 135-65 as the systolic, diastolic and pulse pressure, respectively, and still, other things being equal, have Blood-Pkessure Stethoscoim:. IJl perfect compensation, relation and a normal balance between the various parts of the carflio-Nasnilar system. Before this accurate method of diastolic determina- tion was devised, moderately elevated pressures, which had had only the systolic determination, would not even have been considered by the Insurance Com- panies, or if under observation by a physician, the systolic reading alone would have been misleading. Dr. Faught, in his work on ''Blood-Pressure," says : "The determination of the pulse pressure is of the greatest importance in the study of diseased condi- tions, particularly in the estimate of cardiac muscular efficiency and in determining the prognosis of certain valvular and blood-vessel diseases and toxemic states." Dr. J. W. Fisher, Medical Director of the North- western Mutual Life Insurance Company, in an article, "The Diagnostic Value of the Use of the Sphygmoma- nometer in Examinations for Life Insurance," says : "No practitioner of medicine should be without a sphygmomanometer. He has in this instrument a most valuable aid in diagnosis." Dr. Haven Emerson, in "Archives of Internal Medi- cine," says: "The danger of accepting applicants who are not really entitled to insurance is greatly lessened by the determination of the pulse pressure, and no insurance company desires to refuse a policy to a good risk, and in no way can this be positively ascertained except by the use of the sphygmomanometer." Another observer says : The diastolic readings are more important than the systolic. He further states that the auscultatory method of obtaining the diastolic pressure is now well recognized as the only accurate 122 Auscultatory Blood-Pressure. and simple method, because if you observe the dial of an aneroid, the needle is showing wide excursions, making it impossible to determine the correct reading, as you do not know what point in the excursion of the needle to note. The fluctuations of the mercurial column offer the same difficulty. By observing the changes in pulse pressure of our cases under treatment, we obtain the most accurate idea possible of the results that are being obtained; far more so than when we utilize the systolic pressure alone. Now, accepting the evidence in favor of the import- ance of accurate diastolic determinations and the claim that the auscultatory method is the only accurate one, we pass to the choice of methods. Some physicians have been in the habit of tucking the stethoscope under the cuff. It is obviously impos- sible by this method to avoid crepitus and annoyance and interference with the sounds and to obtain a cor- rect reading, for the instant you release the air by the various methods used with all forms of sphygmoma- nometers the cuff must yield or slip over the stetho- scope, w4th a resulting crepitus. Manifestly, to hold the stethoscope in place manually is both difficult and inaccurate. The Stamp Bracelet Stethoscope may be used with all forms of sphygmomanometer such as the Faught Standard, Faught Pocket, Cardiac, Tycos, Janeway, Stanton, Riva Rocci, etc. In employing this instrument, attach the arm-band of the sphygmomanometer to the arm above the elbow in the usual way, then the Bracelet is quickly and simply adjusted over the radial artery just below the Blood-Prkssuke Stkthoscoi' 123 bifurcation. The especially (lesij^nie(l arterial button fits snugly over the artery; the sounds are read (|uickly with unfailing scientific accuracy. Precision is now assured ; personal errcjrs (jn the part of the observer are eliminated and remarkably ready and general acceptance by the profession at large of the G.P.PILLING & SON CO. PhlLK. "^ Pilling-Stamp Bracelet Stethoscope is proof enough of its high degree of efficiency in giving to the practitioner and the examiner alike an absolutely accurate method of making determinations and getting satisfactory interpretations in blood- pressure. 16 REASONS Why The Pilling -Faught Apparatus is Best 1. There is no mechanical detail of practical value in any sphygmomanometer which is not embodied in those of the Faught-Pilling make. In this apparatus you will find: 2. A scale running to 300 mm. Hg, 3. The scale graduated in milhmeters requires no compu- tation to determine the actual pressure. 4. An adjustable dial which allows for changes in tem- perature and atmospheric pressure, 5. The scale plainly marked in black and red on a white background — easy to read. 6. The aneroid mechanism has four chambers, assuring absolute smoothness in operation. The same advantage as a "six" auto over the old one or two cylinder. 7. The metal pump of convenient size is positively guarded by an air-tight valve. 8. A reliable release valve is conveniently placed on the shank of the pump. 9. The arm-band is standard width (5 inches) and of sufficient length to meet all requirements. 10. The pressure bag measures 9x5 inches. 11. The outer fabric of the arm-band is of washable mate- rial and permits easy sterilization. 12. Arrangement for quick removal of the pressure bag from the outer covering for cleaning and other purposes. 13. An attractive leather case which_ holds the gauge, arm- band and pump, and is of convenient size to fit in the pocket. 14. Permanent accuracy which has been demonstrated by thousands of satisfied users working under all conditions during a number of years. 15. The Faught Apparatus is in general use by thousands of physicians, by the U. S. Government, many life insurance companies and research laboratories, as the standard of accuracy. 16. Not a spring instrument. Pilling-Faught Blood Pressure Service Generally acknowledged supremacy is not the work of a day or a year, but the cumulative result of many years' leadership which compels gradual recognition and emulation on the part of others in the same field. The word Service is the key-note of Pilling Success. With us it signifies much more than the term usually implies. It means service from us to the surgical dealer — from the dealer to the user — as well as the satisfactory service of every Faught Blood-Pressure Apparatus that we have ever manufactured ; the service that will insure satisfactory results at all times. In order to afford this complete service we have built up a fully-equipped organization, comprised of accurate tools and the best mechanics ; have gathered from our own ex- perience as well as that of others the most advanced ideas in blood-pressure apparatus construction. Dr. Francis A. Faught is in daily consultation with us, whose duty is to safeguard the sphygmomanometer user by maintaining the highest standard of scientific accuracy which is essential in such an instrument. The unparalleled demand and world-wide market for the various Faught blood-pressure instruments have made it necessary for us to again and again extend our organization; to enlarge our manufacturing facilities ; and broaden the scope of both our manufactory and methods of distribution. Pilling Service starts from the General Manager's desk and continues down through the various departments to your individual consulting room. Blood-pressure apparatus are usually guaranteed perfect, but a Pilling is more than perfect — it is insured — for it is built by an organization whose watchword has been service. It is our aim and ambition to maintain and augment the high standard of quality that has always been found in Faught-Pilling instruments, and to this end we shall continue to strive for the welfare of every user of Faught Instru- ments. A copy of Faught' s primer as 2vell as a signed certificate is furnished with every apparatus. MADE ONLY BY G. P. PILLING & SON CO. PHILADELPHIA, PA. PILLING-FAUGHT Pocket Sphygmomanometer FAUGHT POCKET ANEROID INSTRUMENT Complete in genuine leather case, with Faught Certificate $22.50 Net ACTUAL SIZE MADE ONLY BY G. P. PILLING & SON CO. PHILADELPHIA, U. S. A. PILLING- FAUGHT Clinical Sphygmomanometer $27.50 Net Is a Portable Pocket Aneroid Type with DOUBLE SIZE DIAL and REGISTERS TO 350 Mm. OTHERWISE SIMILAR TO REGULAR FAUGHT POCKET FAUGHT MERCURY Sphygmomanometer ACCURATELY STANDARDIZED SIMPLE, COMPACT, DURABLE, EASY TO USE Always ready to use ; time required for the observation reduced to a minimum ; no preliminary adjustment of the apparatus required ; mercury cannot be spilled ; no detachable parts to be lost. AN INVALUABLE AID IN DIAGNOSIS, PROGNOSIS AND TREATMENT Indespensable to the General Practitioner, the Internal Specialist, the Surgeon, the Oculist, the Laryngologist, the Otologist, the Gynecologist, the Obstetrician and the Student of Medicine. The FAUGHT SPHYGMOMANOMETER embodies the essen- tials to the earlier instruments -while omitting unnecessary complexity in construction. Thus eliminating the objectionable features and reducing to a minimum the time required for observations. FOR SALE BY ALL SURGICAL INSTRUMENT DEALERS Complete. Avith Arm-band and Metal Pump in Mahogany Case, Avith Signed Certificate of Dr. Faught. Price, $20.00 Net PATENTED AND MADE ONLY BY G. P. PILLING & SON CO, PHILADELPHIA, U. S. A. PILLING SPECIAL FAUGHT PATENT Sphygmomanometer In order to meet the demand for a cheaper model of the Faught mercury instrument, the PilHng Special has been devised. This instrument embodies the salient features of the Faught Standard Sphygmomanometer, and will be found serviceable, accurate and reliable. PILLING SPECIAL MADE IN TWO GRADES No. 7— With stiff arm-band, highly finished metal parts and with mahogany case, 3 x 3^ x i^Yz in., with Faught Certificate, $15.00 Net. No. 2— With soft arm-band and plain oak case, 3 x zK X 14% in., with Faught Certificate, $12.00 Net. FOR SALE BY ALL SURGICAL DEALERS PATENTED AND MADE ONLY BY G. P. PILLING & SON CO. PHILADELPHIA, U. S. A. PILLING -STAMP BRACELET G.P .PILLING &SON CO. PHILK. - FOR AUSCULTATORY BLOOD PRESSURE Described on pa^es 119 to 123 this Primer A valuable addition to every make of Sphygrno- manometers. May be used on any style, such as Faught Mercury Janeway Faught Pocket Stanton Cardiac Mercer Tycos Riva-Rocci PRICE, $5.00 NET MADE ONLY BY G. P. PILLING & SON CO. PHILADELPHIA, PA. THE BOWLES STETHOSCOPE PRICES Midget I in. diam. ----- $4.00 net Small i^ in. diam. ----- 4.00 net Medium 1% in. diam. _ - _ - 4.00 net Large 2/i in. diam. ----- 4.00 net Flat-iron one size only - - - - 4.50 net Extra, Combination H. R. Bell - - .50 net G. P. PILLING & SON CO. SOLE LICENSEES PHILADELPHIA, U. S. A. SHERMAN VANADIUM STEEL BONE PLATES ^ SCREWS /i^ Complete set of i8 plates as shown on wood panel $14.00 Sing-le Plates $1.00 EACH WITHOUT SCREWS 5/8 IN. 1»^ Sherman Screw Driver, $4.00 Net FOR SALE BY ALL SURGICAL DEALERS G. P. PILLING & SON CO. PHILADELPHIA, PA. MERZON UMBILICAL CORD TIE A sealed gflass jar contain- ing- twenty-five yards of a smooth silky finish cord so braided that intense strength is secured in a small narrow braid. MERZON Cord being fiat will not cut or injure tissue. Merzon Cord is so placed in the packag^e and sealed that just the amount required for each operation may be withdraw^n, without soiling: contents of packag^e and the entire contents of jar used without snarling-. Price, TS Cents MERZON Umbilical Cord Tie is the orig^inal and only safe packag-e to handle. Infring-ements of Merzon Cord are on the market and the trade is warned ag-ainst handling- any packag-e other than the Merzon Cord, for which patents are applied for. The Convenience and Low Cost of MERZON and KORDO have made them favorites among" the physicians, nurses, undertakers and veterinarians. They should be found in the stock of every surg'ical instrument house in this country. FOR SALE BY ALL SURGICAL DEALERS HENRY CLAYTON & BRO. Philadelphia, Pa. SOLE WHOLESALE DISTRIBUTORS CAUTION Our attention has been called by physicians to attempted SUBSTITUTION of other makes of Sphygmomanometers by certain retailers because of greater profits. INSIST ON THE PILLING-FAUGHT G. p. PILLING & SON CO. PHILADELPHIA, PA. COLUMBIA UNIVERSITY LIBRARIES This book is due on the date indicated below, or at the expiration of a definite period after the date of borrowing, as provided by the library rules or by special arrangement with the Librarian in charge. DATE BORROWED DATE DUE DATE BORROWED DATE DUE . C28(946)MIOO / / RC74 Faught Fb7 1914 Copy 1 Bloo d^ressure priacr... C-/. ^- I1U.BINDEEY \3\4-