j^oi^fni^^jf^rt^^rikH^U. j (^ J? Q DUPLICATE HXOOO 12882 IS LEPRUSY INCREASING? By FREDERICK L. HOFFMAN, LL. D., F. S. S., F. A. S. A. Third Vice President and Statistician, The Prudential Insurance Company of America, Associate Fellow American Medical Association, Member Royal Sanitary Institute, Member American Public Health Association, etc., etc. AN ADDRESS Delivered at a meeting of the American Medical Association New Orleans, La., April 26, 1920 SCIENTIFIC PUBLICATIONS STATISTICIAN'S DEPARTMENT THE PRUDENTIAL INSURANCE COMPANY OF AMERICA HOME OFFICE, NEWARK, NEW JERSEY (AVAILABLE ON REQUEST) INDUSTRIAL HYGIENE Industrial Accidents and Their Relative Frequency in Different Occupations (1914). The Mortality from Diseases of the Lungs in American Industry (1916). Some Theoretical and Practical Aspects of Industrial Medicine (1917). Mortality from Respiratory Diseases in Dusty Trades — Inorganic Dusts (1918). Menace of Dust, Gases and Fumes in Modern Industry (1918). HEALTH INSURANCE Facts and Fallacies of Comptdsory Health Insurance (1917). Public Health Progress Under Social Insurance (1917). Autocracy and PaternaUsm versus Democracy and Liberty (1918). Failure of German Compulsory Health Insurance: A War Revelation (1918). Health Insurance and the Public (1919). More Facts and Fallacies of Compulsory Health Insurance (1919). National Health Insiurance in Great Britain (1920). * CANCER Educational Value of Cancer Statistics (1914). Accuracy of American Cancer Mortality Statistics (1914). The Mortality from Cancer Throughout the World (1915). Cancer from the Statistical Standpoint (1916). MALARIA A Plea and a Plan for the Eradication of Malaria in the Western Hemisphere (1916). The Malaria Problem in Peace and War (1918). MISCELLANEOUS Rural Health and Welfare (1912). Uniformity of Annual Reports of Local Boards of Health (1913). The Chances of Death and The Ministry of Health (1913). The Economic Progress of the United States During the Last Seventy-five Years( 1914) American Public Health Problems (1915). Leprosy as a National and International Problem (1916). The Sanitary Progress and Vital Statistics of Hawaii (1916). On the Physical Care of Children (1916). The Tuberculosis Death Rate in 1916 (1917). Army Anthropometry and Medical Rejection Statistics (1917). The Mortahty from Degenerative Diseases (1918). A Plan for a More Effective Federal and State Health Administration (1919). Pauper Burials and the Interment of the Dead in Large Cities (1919). Some Statistics of Influenza (1919). Is Leprosy Increasing (1920)? CHARTS Typical Causes of Death Infant Mortality Typhoid Fever Cancer Infantile Paralysis Accidents Influenza Diphtheria Mortality of the United States Leprosy Measles and Germany Malaria Scarlet Fever Pauper Burials Tuberculosis Whooping Cough Army Anthropometry N N I N •^ ■^ -^ § 1 NN I c\< I ^1 ^ ^ ^ ^ ^. ^ V '» §#■? 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FREDERICK L. HOFFMAN, LL. D., F. S. S., F. A. S. A. Third Vice President and Statistician, The Prudential Insurance Company of America, Associate Fellow American Medical Association, Member Royal Sanitary Institute, Member American Public Health Association, etc., etc. AN ADDRESS Delivered at a meeting of the American Medical Association New Orleans, La., April 26, 1920 1920 PHUDENTIAL PRESS NEWARK, N. J. U. S. A. Foreign Agents Messhs. p. S. king & SON, LTD. 2 AND 4 GREAT SMITH ST. LONDON, ENG. CONTENTS Page The Extent of Leprosy in the United States 5 Estimate by Dr. Isadore Dyer 5 Estimate by Dr. Howard Fox 5 Estimate by Dr. Martin F. Engman 6 The United States Senate Committee Inquiry 6 The Literature of Leprosy 6 Modern Views on Segregation 7 Leprosy in Louisiana 8 Leprosy Admissions, by Race, Sex, and Average Age 10 Varieties of Leprosy in Louisiana 10 The Fatality Rate in Leprosy 11 Discharges and Cures 12 Absconding Cases 12 Deportations 13 Leprosy in the Young 13 Treatment and Cure 14 Leprosy in California 14 Leprosy in Massachusetts 14 Leprosy in the United States Registration Area 14 Revised Estimate of Leprosy Cases in the United States 15 Urgent Need for a Federal Leprosarimn 16 Leprosy in Canada _. 16 Leprosy in Cuba 16 Leprosy in Porto Rico 17 Leprosy in Panama Canal Zone 17 Leprosy in Rio de Janeiro 18 Leprosy in Sao Paulo 18 Leprosy in Brazil 18 Leprosy in Argentine Republic 19 Leprosy in Venezuela 19 Leprosy in Barbados 19 National Conference on Leprosy in Argentina 20 Geographical Distribution in Brazil 20 Urgency of a Broader National Interest 20 Recent Cases of Leprosy Throughout the United States, 1916-1920 21 Urgency of a More Qualified Professional Interest 21 Cases of Leprosy in the United States Reported Since 1916 22-27 Need and Value of a National Leprosy Conference 27 Medical and Dermatological Aspects of Leprosy 28 Present Status of the Federal Leprosarium 30 Importance of Accurate and Complete Leprosy Statistics 31 Summary of Conclusions 32-34 CONTENTS (Continued) Page Appendix A — Leprosy in India 35-40 Appendix B — Leprosy Statistics : Leprosy Admissions — Louisiana Leper Home 41 Leprosy Admissions by Age and Sex 41 Leprosy Admissions — San Francisco, Calif 42 Leprosy Admissions — Massachusetts 42 Leprosy Deaths — United States Registration Area 43 Leprosy Deaths by States 43 Leprosy Mortality in Cuba 44 LeprosyCases in Cuba 44 Leprosy in Porto Rico 44 Leprosy in Panama Canal Zone 45 Leprosy in City of Rio de Janeiro 46 Leprosy in Sao Paulo 46 Leprosy in Federal District of Rio de Janeiro 47 Leprosy in Pernambuco 47 Leprosy in Venezuela 48 Leprosy in Barbados 48 Leprosy in India 49 Leprosy Statistics — Hawaii 49-51 Leprosy in Union of South Africa 51 Leprosy in United States, 1920 — by States 52-53 CHARTS Leprosy in the United States , Frontispiece Leprosy in Louisiana 9 Leprosy in Hawaii 29 IS LEPROSY INCREASING! The Extent of Leprosy in the United States The question as to whether leprosy is on the increase in this country is one of considerable medical, general scientific, and humanitarian inter- est. The question, unfortunately, can not be answered in a satisfactory manner by an appeal to thoroughly trustworthy statistics, for neither the Federal Government nor any one of the several States has undertaken an investigation commensurate with all that is involved in whatever answer may be forthcoming. At best only an approximate guess can be advanced as to the probable number of lepers in the United States at the present time, but it is safe to assume that the actual number is less than the earlier estimates would seem to justify. An attempt to answer the question by an appeal to statistical evidence was made at the time when the Senate Committee on Public Health and National Quarantine considered the establishment of a national leprosarium for the care of leprosy cases, chiefly of an international or interstate character. The results of several inquiries made of State and local boards of health throughout the country seem to indicate that there are probably not far from two hundred and fifty officially known cases of leprosy in the United States, and possibly as many as five hundred cases known and suspected. The United States Public Health Service has given publicity to similar inquiries but they have never been inclusive of all the States and the localities not required to report to some central authority.* Estimate by Dr. Isadore Dyer Dr. Isadore Dyer, of New Orleans, probably the foremost leprologist in the United States, in his evidence before the Senate Committee on Pub- lic Health and National Quarantine, on March 26, 1916, referred to an estimate, according to which the number of cases of leprosy in the United States was four hundred, of which probably three hundred and fifteen were cases in the State of Louisiana. This, however, was a statement based upon inquiries made some years earlier, and Dr. Dyer in his evidence presented a revised estimate, according to which he placed the number of lepers throughout the United States in 1916 at from 800 to 1,200, basing his conclusions upon the observed experience and apparent rate of increase in the State of Louisiana. Estimate by Dr. Howard Fox Dr. Howard Fox, of New York, Clinical Professor of Dermatology, also a recognized authority on leprosy, placed a statement before the same committee, according to which the number of leprosy cases in the ♦In 1907 the United States Public Health Service traced 139 cases of leprosy in the continental United States. In 1912 the nnmber so ascertained was 146. In 1920, according to my own inquiry, there are 242 cases. (See table XXIV, Appendix B.) United States was estimated at from 500 to 1,000. Dr. Fox, however, apparently had based his estimates largely upon his experience in the city of New York, where some thirty cases had come mider his personal observation. According to his estimate the nmnber of cases of leprosy in the city of New York at that time was fifty. Estimate by Dr. Martin F. Engman Dr. Martin F. Engman, Professor of Skin Diseases, Washington Uni- versity, St. Louis, testified that, in his judgment, an estimate of 800 leprosy cases in the United States was entirely too low, and he went so far as to intimate that the probable number was three times as large. In support ofi his statement he directed attention to a return of the United States Public Health Service for the year 1911, according to which there was only one case of leprosy m Missouri, when, to his personal knowl- edge, there were certainly at the time three cases in St. Louis alone. He, however, was frank to say that it was impossible "to estimate the nmnber of cases of leprosy in this coimtry with any accuracy at all." The United States Senate Committee Inquiry It would serve no practical purpose to enlarge upon the various esti- mates presented, since in not a single case has the evidence been forth- coming that a really thoroughgoing effort had been made to ascertain the facts. It was my privilege at about that time to present to the Senate Com- mittee a first effort to assemble the leprosy statistics of foreign countries making at least fairly trustworthy returns, and a mass of material was printed in the report of the committee, which is still available to those who may wish to pursue the subject further. (Senate Report 306, 64th Congress, 1st session, Washington, 1916.) The Literature of Leprosy In continuation of the earlier investigation (Senate Report of 1916), I am now able to present some additional and more recent statistics, which, though largely for other countries than the United States, certainly emphasize the sinister aspects of leprosy occurrence in isolated cases as they are met with from time to time in this coimtry. For, whatever views may be held regarding the spread of the disease, no one can question that leprosy foci, once thoroughly established, are extremely difficult, if not impossible, to eradicate. The literature of leprosy is widely scattered and difficult of access to those who suddenly find themselves confronted by the necessity of the highly specialized care of some isolated case of leprosy, usually, in this country, outside of Louisiana, contracted in the Philip- pines, Hawaii, or the West Indies. Among the more important works which throw light and a wealth of useful information upon the etiology of this obscure disease, mention requires to be made of "A Handbook on Leprosy," by S. P. Impey, M.D., late chief and medical superintendent of the Robben Island Leper Asylum, Cape Colony, South Africa. Another very useful dissertation is a report on leprosy in Hongkong, by James Cantlie, M.A., F.R.C.S., Hongkong, 1890. Of special value are the "Prize Essays on Leprosy," issued by the New Sydenham Society in 1897, including, first, a contribution to the history of leprosy in Australia, by J. Ashburton Thompson, M.D. ; and, second, a report on the conditions under which leprosy occurs in China, etc., compiled chiefly during 1894, by James Cantlie, One of the most thorough investigations ever made into the subject is a report of the Leprosy Commission of India (Calcutta, 1893), which may well be con- sidered a model for a similar inquiry in this country. This investigation includes the results of personal examinations and observations on the geographical distribution of leprosy in its relation to climate, soil and race, illustrated by properly drawn maps visualizing the local degree of frequency of the disease throughout India. The observations on the local incidence of leprosy are amplified by an extended consideration of such involved questions as hereditary transmission and predisposition, con- tagiousness, sanitation, diet, other diseases, and, finally, the important question of proper treatment. Through the courtesy of G. M. Young, Esq., Under-Secretary to the Governor of India, I have been favored with a copy of this valuable report, and of a supplementary memorandum pre- pared by a special committee in behalf of the National Leprosy Fund. It is difficult to clearly grasp the significance of much of the general discussion relating to leprosy at a time when the views of highly respected authorities were widely at variance both as to the cause of the disease and the methods of its transmission. I need only refer to the treatise on "Leprosy and Fish Eating," by Sir Jonathan Hutchinson, and to even better purpose to the report on "Leprosy and Yaws in the West Indies," by Gavin Milroy, a fellow of the Royal College of Physicians, London, 1873; or, of more recent date, to the reports on "Nastin and Benzoyl- chloride Treatment for Leprosy," by Dr. E. P. Minett, Assistant Govern- ment Bacteriologist of British Guiana, London, 1912.* Modern Views on Segregation A review of the literature clearly emphasizes the inadequacy of the medical and general scientific considerations of a disease which, partly because of its obscurity and largely because of its more intensive limita- tion to primitive races, has not attracted the attention to which it is cer- tainly, by every himiane consideration, entitled at the present time. Even ♦The modem literature of leprosy is so extensive as to preclude even a mere mention by title of the most important contributions, but a reference requires to be made to one of the Prize Essays on leprosy published by the New Sydenham Society, 1895, containing also an important paper by Doctor (now Sir) George Newman, on "The History of the Decline and Final Extinction of Leprosy as an Endemic Dis- ease in the British Islands." The same volume includes a most interesting essay on "Conditions Under Which Leprosy has Declined in Iceland," by Edward Ehlers, M.D., and a paper on "Leprosy in South Africa," by S. P. Impey, M.D., with some supplementary observations on "Spontaneous Recovery from Leprosy," based upon self-cured cases, presented to the medical congress held in Cape Toivn. Of im- portance also is a contribution to the New Orleans Medical and Surgical Journal of July, 1917, on "Early Manifestations of Leprosy," by Doctor Ralph Hopkins, in medical charge of the Louisiana Leper Home. Invaluable in this connection are the special reports upon leprosy prepared by the United States Public Health Service, being the contributions made by the surgeons in charge of the United States Leprosy Investigation Station in Hawaii. so useful and otherwise comprehensive a work as the new "Reference Handbook of the Medical Sciences" limits the discussion of leprosy by Dr. Dyer to less than six pages; but I may appropriately quote here Dr. Dyer's conclusion that, "The sanitary control of leprosy should be prac- ticed by every government for the protection of the public and for the care of the leper. Segregation has proved the best method of checking the spread of the disease and this is the basis of the practice in most coun- tries." He therefore remarks, "National leprosaria will solve the question of leprosy incidence, and the laboratory gives promise of finding some specific." It was largely upon this principle of precedure that the small group of men who appeared before the Senate Committee in 1916 presented their case and carried their point, for be it said to the honor of the United States Cozigress that an appropriation was promptly made of $250,000, an amoimt fully sufficient for the purpose. The bill was signed by the Presi- dent on February 3, 1917. In the argvmients presented to the committee emphasis Avas placed upon the international aspects of the disease and the fact that, outside of the State of Louisiana, most, if not nearly all, of the sporadic cases of leprosy in the United States had been contracted in foreign countries or in our non-contiguous territories. It was chiefly on this grovmd that the Senate Committee made a favorable recommendation, it being clearly understood that it was not the intention of the States represented to place upon the Federal Government the burden of care in the case of leprosy clearly or unmistakably of native origin. This conclusion applies par- ticularly to the State of Louisiana, where leprosy has been met with for more than a hundred years and where the disease has its largest endemic center in the United States.* Leprosy in Louisiana The Louisiana Leper Home was established by an act of the General Assembly of Louisiana, passed in the year 1894, the location of the home being near Carville, in Iberville Parish, about sixty miles from New Orleans, on the banks of the Mississippi River. The nimiber of new cases admitted to the Louisiana Leper Home in 1894 (being opened on December 1st) was only eight, but during the fol- lowing year eighteen cases were admitted, and since that time the number has varied, reaching a maximum of twenty-seven new cases during the year 1913. The average number of cases admitted during the period 1895- 1899 was seven, or 5.2 admissions per million of population per annum, which compares or contrasts with an average of twenty-one cases annually or llA admissions per million during the five years ending with 1917. The number remaining in the institution at the time the report was made in April, 1916, was 103, or the largest nimiber on record. The returns for ♦There is record of a leper hospital at New Orleans as early as 1785. It has been claimed that the disease was introduced by the Acadian refugees from Nova Scotia after their expulsion by the English. o a I 3.- E I- OP E I 3^- 1-1 ■■lll -llllllll. 5^ '=!) S^ S "S si 5^1 H^ I I I I ^ «rN 2> 5 s <3 CM x^ I I II lU ^ !0 ^ 1 1 § O lO O ^J^ o ks to u"! ^y ^ S i£i 2 to OS i I St I ^^ I I §• 5s -/^ / \ ^ 1 is; I / 1 ^ \ ^ } 7^ ; \ 1 " 1 n»J i]k 1 1 -j 1^ 1 ^ \ ,-^ - ■5. tl ill i.|| ^J J 1^ / ■i^ ./ \ the year 1919 are not available at this writing, but they will subsequently be inserted as a matter of convenient record.* The Louisiana data, which are given in full in table I of Appendix B, seem to justify the conclusion that leprosy is increasing in Louisiana; or, if not, that the niunber of ru)n-segregated patients is larger than is gener- ally assumed to be the case. This, as I understand it, is the view held by Dr. Dyer, whose judgment is entitled to the utmost consideration. It may be said in this connection that leprosarium admissions depend largely upon the reputation of the institution for the care and medical treatment of the patients as well as for the beneficial results secured in particular cases. I^EPROSY Admissions by Race, Sex and Average Age The Louisiana Leper Home is in many respects an admirable institu- tion, which has been fortunate enough to be under the supervision of a hmnane board conscious of its profoimd obligations towards the most afflicted members of the community. It has, furthermore, the great advan- tage of constant medical supervision on the part of Dr. Ralph Hopkins, who makes a weekly visit to the institution, and more often if urgently required. The table following presents an analysis of 257 cases admitted to the institution during the period 1894-1915, differentiating the type of the disease, the race and sex of the patient, and the average age on admis- sion according to the diagnosed variety of leprosy : analysis of admissions to leper home, la. For the Period, December 1, 1894, to December 31, 1915 Average Age on Admission by Type of Disease MALES FEMALES Type of White Colored White Colored Disease No. Av . Age Yrs. No. Av. Age Yrs. No. Av. Age Yrs :. No. Av .Age Yrs. Tubercular 38 32 14 39 18 42 6 41 Anesthetic 32 28 6 34 19 35 3 27 Mixed 46 33 10 41 30 36 6 31 Trophic 10 36 2 53 4 31 3 58 Unknown 2 40 — ■ — — — — — Total 128 32.0 32 39.5 71 37.1 18 38.1 Ages Unknown 4 — 1 — 2 — — — Males and Females No. Av. Age Yrs. Tubercular 76 36.4 Anesthetic 60 31.0 Mixed 92 35.0 Trophic 20 (x) 41.7 Unknown 2 40.0 Total 250 35.0 Age Unknown 7 (x) Includes one Chinese, age 75. (Male.) Data from Biennial Reports of the Board of Control. Varieties of Leprosy in Louisl\.na Of the 257 admissions, 205, or 79.8 per cent., were white persons. The corresponding proportion of whites in the total population of Louisi- *The number remaining in 1920 is 87. 10 ana was 56.9 per cent, at the time of the 1910 census. The average age on admission, disregarding the type of the disease, was 32 years for white males and 39.5 years for colored males. For white females the average age on admission was 37.1 years, and for colored females, 38.1 years. There would, therefore, appear to be a tendency towards a somewhat higher age on admission in the case of the colored patients. Combining both races and sexes, of the 257 admissions, 77, or 30.0 per cent., were of the clearly differentiated tubercular variety, 62, or 24,1 per cent., were of the anesthetic variety, and 95, or 37.0 per cent., were of the mixed variety, the proportions varying according to race and sex, but it is safe to say that the mixed variety is the predominant type. The fact that the mixed variety predominates complicates the question of treatment and makes segregation even more important than would ordinarily be the case. The mixed variety apparently has a slightly higher average age on admission, while the anestlietic variety has a lower age than the tubercular for both sexes and both races separately considered. The Fatality Rate in Leprosy The next table shows an analysis of the experience during the period 1894-1915, indicating the fatality ratios and the cures, with a due regard to sex and type of disease: ADMISSIONS TO THE LOUISIANA LEPER HOME According to Type of Disease, Mortality, and Cures December 1, 1894, to December 31, 1915 Males Type of Admissions I )ied Disease No. No. % Tubercular 52 18 34.6 Anesthetic 40 9 22.5 Mixed 58 38 65.5 Trophic 13 7 53.8 Unknown 3 — - — Total 166 72 Females 43.4 Tubercular 25 6 24.0 Anesthetic 22 9 40.9 Mixed 37 20 54.1 Trophic 7 4 57.1 Unknown — Total 91 39 42.9 Males and Females Tubercular 77 24 31.2 Anesthetic 62 18 29.0 Mixed 95 58 61.1 Trophic 20 11 55.0 Unknown 3 — Ci jred No. % 2 3.8 4 10.0 1 1.7 4.2 6 24.0 4 18.2 2 5.4 12 13.2 8 10.4 8 12.9 3 3.2 Total 257 111 43.2 11 19 7.4 Discharges and Cures The interesting fact is brought out by this table that of the total male admissions, numbering 166, seven cases, or 4.2 per cent., were discharged as cured. Of 91 females, twelve cases, or 13.2 per cent., were discharged as cured, but it is hardly safe to draw far-reaching conclusions according to the type of the disease and the apparent degree of curability, with refer- ence to sex, on account of the smaller number of women patients under observation. In the case of male patients, however, it is significant that the proportion of deaths should have been highest for the mixed type of the disease, or 65.5 per cent, of the admissions, the corresponding percentage for females having been 54.1. For the tubercular type of the disease, the mortality rate was 34.6 per cent, for males and 24.0 per cent, for females. The fatality rate, of course, is largely influenced by the duration of treat- ment and the attained age of the lepers under segregation, as well as by the rate of admission of new cases. No definite conclusions can be drawn from this experience as to the greater or lesser degree of curability of specified types of leprosy, but the method used emphasizes the value of an extended statistical analysis of the facts derived from a larger area of observation. For all types combined the mortality rate was 43.4 per cent, for male patients and 42.9 per cent, for female patients, or almost the same. Many other interesting facts are brought out by the statistical tables appended to this discussion, which are practically self-explanatory. With- out unduly enlarging upon the facts as disclosed by table II, Appendix B, it may be said in this connection that the age period at which the larger proportion of leprosy admissions occurred in Louisiana was 20-29. At this period of life there were 34 admissions, or 20.5 per cent, of the total of 166 male admissions, while of 91 females the greatest number was admitted at ages 40-49, but almost the same niunber was admitted at ages 20-29. A discussion of the statistical results of this investigation is naturally difficult on account of the race factor, which can not be safely ignored, but an extended consideration of which would unduly trespass upon the time available, and more so in view of the fact that the details are given in the tables in the appended tabular analysis. Absconding Cases It has not been possible for me to deal with the question of escapes, but from every center of leprosy the information is clearly to the effect that escapes are not only inadequately safeguarded against but in some cases encouraged. The Early case of the District of Columbia is a con- spicuous illustration of our failure to recognize the menace of leprosy to the community at large. Most of the cases apprehended have previously been unrecognized leper residents of other communities. In Louisiana last year fifteen cases absconded, but what became of these cases is not known. In California last year at least three cases, and probably more, escaped from detention hospitals. It is always a foregone conclusion that an 12 escaped leper will be apprehended within a comparatively short period of time on account of the urgency of the special treatment required to bring relief. In view, however, of the recognized infectious character of the disease, or its transmission from person to person by actual contact, the danger to the community on account of such cases is real and not imaginary.* Deportations I am not able to discuss in full detail the question of deportations. The reports of the Surgeon General do not indicate how many lepers are annu- ally deported. Under the law a foreign-born leper must be a resident of this country five years before he acquires a settlement. Most of the cases of foreign-born lepers have been residents of this country for many years, although the disease was unquestionably contracted abroad. Accurate information would be of value, for unquestionably leprosy im- portations would be discouraged if the facts of deportation were better understood. It would also be of value to have the duration of previous residence in this country accurately ascertained to determine whether cases should be deported that now are a burden and expense to communities ill- provided with proper facilities for leprosy care. The question may be raised in this connection whether our methods of examination for leprosy at quarantine are really adequate to the purpose. It does not appear that special emphasis is placed upon the urgency of ascertaining cases of leprosy in the incipient stage of the disease. It is possible that the Bureau of Immigration has information on the subject, for the records should show the number of cases refused admission to this country on account of leprosy, as well as the number deported. Leprosy in the Young One important phase of the subject is leprosy in the young. There are in this country at the present time a number of very suggestive cases of children suffering from leprosy evidently contracted from leprous parents. There are or were two or three such children at the Alameda County Hospital, Oakland, Cal., and there are at present two such children at Phillipsburg, N. J., ill-provided with the required special institutional care. Since a leper under certain conditions may live for many years with the disease in a quiescent or arrested stage the pecuniary aspects of this question are a matter of serious importance to the localities concerned. *The importance of this observation is illustrated by the very recent case of Willard Centliver, a leper, who surrendered to the authorities of the City of Washington, as reported in the Washington Post of March 28, 1920. He had arrived in Washington a few days before from Birmingham, Alabama, having made the trip in a Pullman car, but he had destroyed the car check so as to preclude the identification of the method by which he had evaded detection. This man was accepted for army service in New Orleans in 1917, having subsequently been transferred to Camp Beauregard, Louisiana. His condition being ascertained, he was sent to the Louisiana Leper Home from which he escaped and went to Houston, Texas. From there he returned to New Orleans and subsequently by way of Birmingham reached Washington, where he entered a clinic and reported his condition. He could give no explanation as to how or where he had contracted the disease. 13 Treatment and Cure The question of treatment and cure does not fall within the present discussion but it has an important bearing upon the problem of leprosy increase in that the numbers remaining are naturally determined in part by the results of institutional care. There is apparently a distinct tendency towards a larger proportion of cases discharged as cured, or certainly in an arrested condition of the disease, justifying a diagnosis of at least relative harmlessness to the community at large. In proportion, however, as cases to an increasing extent are discharged as cured the number remain- ing would indicate a diminished frequency of leprosy in the community, although the contrary might be the case. This fact is frequently overlooked in discussions of leprosy increase, and care is therefore necessary in con- sidering the statistical results. Leprosy in California One of the most important centers of leprosy in the United States is the Isolation Hospital at San Francisco, where generally from fifteen to twenty lepers are segregated by the County of San Francisco, there being in addition some nine lepers at the County Hospital of Alameda County, near Oakland. The leprosy cases in San Francisco show no material in- crease during recent years, bift there are reasons for believing that cases are not effectively segregated, but apprehended in other counties, as best illustrated by some very interesting apprehensions in Fresno, in the heart of the San Joaquin Valley; and even more so by the Los Angeles County Hospital, where at the present time five lepers are under control. Details regarding the San Francisco cases are appended hereto (table HI, Ap- pendix B), but it must be kept in mind that it is always more difiGcult to secure trustworthy data for institutions which care for only a small number of cases, not on the basis of adequate leprosy segregation but rather on the principle of isolation and quarantine control. Leprosy in Massachusetts Some exceptionally interesting data are available for the Massachu- setts Leper Colony at Penikese Island, in Buzzard's Bay, where the num- ber under segregation is generally about twelve, but probably some- what higher at the present time, a maximum having been reached in 1913, when fifteen cases were under segregation.* Some interesting details of racial origin, age, and type of disease, are also included in the appen- dix (table IV, Appendix B.) Leprosy in the United States Registration Area The foregoing statistics indicate the best sources of leprosy informa- tion for the United States, but there can be no question of doubt that the disease is widely scattered and that obscure cases occur here and there, though frequently erroneously diagnosed or not recognized at all except ♦Number under segregation on January 1, 1920 was 13, with 2 more cases reported during the month. 14 in the terminal stage of the disease. It may be pointed out in this connec- tion that in the United States registration area, with a population of about 82,000,000 in 1918, there occurred twenty-four deaths from leprosy, equivalent to a rate of 0.29 per million of population. The rate in the registration area has apparently increased gradually from 0.13 in 1900 to 0.19 in 1910, and, as stated, to a maximum figure of 0.29 in 1918. (Table V, Appendix B.)* Revised Estimate of Leprosy Cases in the United States If the normal death rate of leper cases is placed at 80 per 1,000 tmder segregation, then the twenty-four deaths from leprosy which occurred in the United States in 1918 would be equivalent to 300 probable cases of leprosy in the registration area, and if this figure is applied to the con- tinental United States, the number of leper cases, on a very conservative basis, is not less than 400. The distribution of leprosy deaths in the registration States, by single years, since 1900, is given in table VI of Appendix B, but the fact must not be overlooked that some of the States have been included in the registration area during recent years only. The inadequacy of this return is made clear by the statistics for the State of New York, where unquestionably a larger number of deaths from leprosy occur than the recorded two deaths, for illustration, during 1918. There has been for many years an attitude not far from indifference on the part of the New York authori- ties towards the imperative medical and humane duty of segregation, which is so much more lamentable since it is safe to assume that there are certainly not less than thirty and possibly as many as fifty cases of leprosy in the city of New York at any given time. That cases in the city of New York are of national concern is shown by sporadic outbreaks. Cases in New Jersey, for illustration, have been directly traceable to leprosy con- tact on Blackwell's Island. There are at the present time two leper chil- dren in Phillipsburg, N. J., whose mother died from the disease in the city of New York.f If, therefore, the available statistical evidence is not entirely conclusive it is certainly extremely suggestive of a possible, though slowly increasing, frequency of this most dreaded of all human afflictions. The experience which has been had in other countries proves conclusively that leprosy increases as long as segregation is neglected, but that the disease slowly declines when the cases are brought under control in one or more care- fully supervised institutions such as the act of February 3, 1917, provides shall be established in the United States under the direction of the United States Public Health Service. *0f course, not all lepers die of leprosy, so that the reported figure is an understatement of the whole truth of leprosy occurrence in the registration area. See table IX, Appendix B, for Barbados. tFor the official viewpoint that leprosy is not contagious or infectious in this climate, see J. A. M. A. of November 13, 1897, p. 1021. and November 27, 1897, p. 1126. 15 Urgent Need for a Federal Leprosarium The urgency of a federal leprosarium is not questioned by anyone familiar with the facts. It requires only to be considered that during the period 1907-18 there have been not less than 138 deaths from leprosy in the United States registration area, which is exclusive of a considerable rural and Southern section in which leprosy cases are likely to occur. Delay in the establishment of a federal institution for the care of lepers must therefore be considered, on humane as well as on medical grounds, a wrongful indifference on the part of those who are responsible for the execution of the law". The obstacles to the selection of a suitable site can not be considered serious, and least so in the case of Ship Island, Miss., where there are suitable buildings which could long since have been converted into a most useful institution for the care and relief at least of interstate and international leprosy cases throughout the South. Before 1 enlarge upon the practical aspects of the question of adequate care under segregation it may not be out of place to direct attention to certain facts of leprosy occurrence throughout the Western Hemisphere which bear directly upon our own problems at home. Leprosy in Canada There has for many years been a very limited leprosy center in the Province of New Brunswick, dating back certainly as far as 1815, and prob- ably to a much earlier period. As many as thirty-two lepers were segre- gated at Shell Island about 1844, and these were later transferred to the present leprosarium at Tracadie, where twenty-one lepers were cared for in 1863. As the result of segregation the number of patients has gradually diminished to twenty-four in 1898 and fourteen in 1916 with no new admis- sions for the two years preceding the date of the last return. In 1907 the Canadian government assimied federal control over all leprosy cases, and a lazaretto was established at Darcy Island, B. C, for the care of cases on the Pacific coast. There have been sporadic cases of leprosy in Manitoba, chiefly of Icelandic or Scandinavian origin. It may be questioned whether there are more than twenty-five active cases of leprosy throughout Canada at the present time. There were five cases at Darcy Island in 1919 and thir- teen cases at Tracadie. Leprosy in Cuba In Cuba there occur probably fifty deaths from leprosy per annum, equivalent to a rate of 20 per million of population. As far as it is pos- sible to judge the disease is slightly on the increase, partly because of the lack of adequate methods of segregation, although probably more is done by the Republic of Cuba than in the United States. In Cuba leprosy appears to affect chiefly the white population, for in 1914 there were thirty-five deaths of white lepers to ten deaths from leprosy among the negroes. (See tables VII and VIII, Appendix B.) * ♦According to the Bulletin of the Pan-American Union for September, 1916 "The construction of a new leper hospital building was provided for at an expense not exceeding three hundred thousand dol- lars." In January, 1917, the lepers under segregation at the lazaretto in the city of Havana remon- strated against their proposed removal to the new institution at Mareal. Out of one hundred and leventy- four lepers, it is said twenty escaped. 16 Leprosy in Porto Rico In Porlo Rico leprosy is fairly common, the number of known cases being thirty-nine in 1919, or 30.9 per million of population. This com- pares with about 154 known leper cases per million population for Cuba, but the evidence of an increase in the frequency of the disease is much more pronounced for Porto Rico, or, for illustration, a rate of 17.3 for 1905 contrasts with 24.3 for 1912 and 30.9 for 1919. (See table IX, Appendix B.) * Leprosy in Panama Canal Zone In the Panama Canal Zone leprosy is also of relatively common occur- rence, the lepers being segregated in a settlement at Palo Seco, near the canal entrance, including, however, admissions of Panamanians from the republic at large. The number of cases remaining under observation in 1918 was seventy-six, or 693 per million of population, a very marked excess over the known rates for Cuba and Porto Rico. There were eight deaths from leprosy in 1918, equivalent to a rate of 72.9 per million of population, which compares with the rate of 19.7 for Cuba for the year 1914. The returns for the Panama Canal Zone also indicate an increase, at least in the recorded frequency of leprosy, the rate having been 137.1 for 1907, 348.6 for 1913, and 692.6 for 1918. The Palo Seco returns, however, are not entirely complete in that sporadic cases of leprosy are occasionally taken care of in the hospitals of the Panama Canal Zone. It may be said in this connection that the prevailing variety of the disease in Panama is tubercular, or twenty-four deaths out of thirty-three during the period 1907-1915; while an overwhelming proportion of admissions is represented by native Panamanians and negroes, there having been only three deaths of white persons during the period under review out of a total of thirty-three deaths of all races and nationalities. Two of the white decedents were natives of the United States. The Senate report on leprosy contains much information concerning the frequency of the disease throughout the West Indies, which to enlarge upon would unduly trespass upon the time available for the present dis- cussion. It seems advisable, however, to briefly direct attention to the leprosy returns for certain countries of South America, which are deserving of more consideration than has heretofore been given to the relative fre- quency of the disease in the Pan-American republics. (See tables X and XI, Appendix B.) *The lepers of Porto Rico are isolated on Cabras Island at the entrance of San Juan Bay. In 1917, however, this institution had only thirty-four patients. The Journal of the Porto Rico Medical Association quoted in the Journal of the American Medical Association of 1918 contains the report of a committee appointed to investigate leprosy conditions in Porto Rico. This report brought to light decidedly unsatis- factory conditions, particularly as to the water supply and acessibility. The committee recommended that the present site be abandoned and that the lepers be removed "to a fertile portion of the mainland of Porto Rico," and that "principles of modern sanitary management be applied to the care and treatment of the disease in place of the present state of hopeless isolation." The New York Times of April 13, 1919, contains an account of this colony reflecting seriously upon existing conditions, stating the sanitary con- ditions to be deplorable and directing attention to the totally inadequate medical supervision. The article concludes with the statement that "Common human kindness should prompt the authorities of Porto Rico to have the unfortunates transferred to some other place, where at least they could keep dry in damp weather." and, it is said, "Surely these poor outcasts need some one's help." 17 Leprosy in Rio de Janeiro For Rio de Janeiro the statistics indicate a relative mortality from leprosy of about 30 per million of population, there having been twenty- three deaths from this disease in 1918. The returns are available since 1890 and indicate neither a pronounced tendency towards an increase nor a decided diminution. It may therefore be said that the disease has apparently reached a stationary condition, in Rio de Janeiro at least, while for Recife (Pernambuco), the available data indicate a decided decrease since 1907, from a rate of 112.9 per million of population to 37.5 in 1917. (See table XII, Appendix B.) , Leprosy in Sao Paulo For the city of Sao Paulo, however, the returns are less reassuring, for there the condition also appears to be apparently a stationary one. In 1901 the nmnber of deaths from leprosy was equivalent to 17.5 per million, but by ] 910 the rate had increased, probably due largely to more accurate methods of reporting, to 65.6. In 1917 the rate was 57.5 per million, but apparently the changes in the rates can not be relied upon as a definite indication of an increase or decrease in the frequency of the disease. (See table XIII, Appendix B.) Leprosy in Brazil Some interesting statistics are available for the Federal District of Rio de Janeiro, for the period 1909-18, indicating a relative annual mor- tality from leprosy of 27.9 per million of population for males and 18.8 for females. The rate increases with age, as shown by a table hereto appended, from a minimum mortality in infancy to a maximmn mortality in advanced adult life. (Table XIV, Appendix B.) In addition, there is included a table of leprosy mortality in the Federal District of Rio de Janeiro, by nativity, showing, at least for the male population, a decided tendency towards a higher rate on the part of the natives, but the data are not sufficient for entirely safe conclusions. (Table XV, Appendix B.) They would seem to indicate, however, a lesser disease liability on the part of the native Brazilians than on the part of the foreign-born. The same conclusion applies to the relative frequency by race, but in this case the fact must not be overlooked that the age dis- tribution of the mixed population may possibly be much at variance with the corresponding distribution of the pure white or black population. (See table XVI, Appendix B.) * *Under date of August, 1919, a report was issued to the eJFect that a new and model leprosarium was under construction in Santo Angelo "which will be the best of its kind in all South America and have all facilities for the isolation and treatment of lepers." Under date of January 10, 1920, the American Medical Association, quoting from a Brazil medical periodical, states that a committee had reported: "We question whether it is advisable to leave lepers in their homes under special surveillance or [not better] to segregate them." Further directing attention to the beneficial results of segregation in Norway, where in fifty-seven years the number had been reduced to less than three hundred cases. It is said that "In Norway the central government has control over the whole country, and uniform methods of surveillance could be applied." The report however, emphasizes that conditions in Brazil are very different, there being no uniformity possible in the twenty states of Brazil under existing conditions. Hence "the con- clusion that segregation is the only practical system for the prophylaxis of leprosy." But the committee urges that the leprosariums should be easy of access to friends and attractive. 18 Leprosy in Argentine Republic Some very interesting statistics are also available for Argentina, where a national conference on leprosy was held in Buenos Aires in 1906, when the number of lepers throughout Argentina was returned as 724. Of this number, 272 cases were found in the Province of Corrientes, 144 in the Province of Buenos Aires, and 123 in the federal capital. Between 1906 and 1916 there were 350 cases of leprosy treated in the hospitals of the Republic of Argentina.* Leprosy in Venezuela In Venezuela, so far as the death rate can be relied upon, there is apparently a tendency towards a decline, for the highest rate, for 1905, was returned as 31.0 per million of population, while by 1912 it had been reduced to 22.5, and in 1918 to 9.8. In the meantime, however, the num- ber of inmates at the leper asylum has not undergone a material change, there being 666 cases in 1907, or 251.3 per million of population, against 582, or 211.2 per million, in 1912, and 753, or 262.5 per million, in 1918. (See table XVII, Appendix B.)t Leprosy in Barbados Thus the evidence is quite sufficient to emphasize the conclusion that leprosy in the Western Hemisphere is endemic and possibly on the in- crease, and that therefore no country, and particularly no port of entry, can be considered safe or inunune against the risk of a possible further introduction of the disease into this country from nearby republics with which our commercial relations are constantly expanding.^ The disease prevails in Costa Rica, in Venezuela, on the west coast of South America, in Dutch Guiana, and in practically all the West Indies, and particularly in the island of Barbados, which is a source of considerable emigration to this country. In Barbados the disease appears to be stationary, but evidence is not wanting that lepers from Barbados have been apprehended in the ♦According to the Journal of the American Medical Association for November 15, 1917, no successful attempt is apparently made in Argentina to isolate all the lepers but it is planned "to construct a large leprosarium with accommodations for five hundred patients in the Chaco district." The report protests against an inland leper colony of this kind on the ground that "it is just adding fuel to the fire," and suggests that "the leper colony should bo on some island apart from the centers of population and every member should be given land. It should be a free farming community except that the inmates should not be allowed to leave the island." tThere are two leprosariums in operation in Venezuela. The largest is on the Isla de Providencia, located just outside of the harbor of Maracaibo, with accommodations for seven hundred patients. . The other is at Cape Blanco, about four miles from Lagiaira. JThe most interesting statistics of leprosy are those available for certain provinces of India. Accord- ing to the census of the Northwest Frontier Province there were three hundred and forty-four cases of leprosy in 1881, diminishing to two hundred and seventy-six in 1891, increasing slightly to two hundred and ninety-four in 1901 and diminishing again to two hundred and eighty-two by 1911. It is observed in the return that "in the case of leprosy we could find no persistent tendency in any direction towards an increase or a decrease in the frequency of the disease." But in this connection it is said that "it is in the case of leprosy that the danger of wilful concealment is greatest, especially when the leper is a female of respectable status." This would explain the lower ratio of women lepers almost invariably met with where trustworthy data are available." It is pointed out that "errors of diagnosis no doubt detract from the accuracy of the figures, for it is often difficult to distinguish leprosy from other diseases which exhibit similar symptoms, such as leucoderma and syphilis." In this connection there may be quoted the further observation that "The causes which predispose to the disease do not seem to have been accurately determined; and no correspondence could be traced between the physical and climatic con- ditions or between the race or the staple diets of the inhabitants of the tracts of India in which leprosy was found to be especially common." (See appendix A and table XIX, Appendix B.) 19 United States. During the period 1890-1917, 426 lepers have died in Barbados, and of this number, 246 were males and 180 were females, an overwhelming majority of the cases being of the tubercular variety, or 291 out of a total of 426. The average duration of treatment was longest in the anesthetic type, or 9.6 years for males and 11.5 years for females; but for the tubercular type the average length of treatment was only 4.5 years for males and 4.8 for females. The Barbados figures are of special value in that, through the kindness of the authorities, I have been fur- nished with a return in detail as to the causes of death, with distinction of type, the facts being given in table XVIII, Appendix B, appended hereto as an interesting contribution to a phase of the leprosy subject which has heretofore, received totally inadequate consideration. In many of the discus- sions of leprosy it is not clear whether the references are to lepers, or deaths from leprosy. As shown by the Barbados returns, of the total number of deaths of lepers from all causes, or 426, the number of deaths from causes other than leprosy was 165, or 38.7 per cent. National Conference on Leprosy in Argentina* These considerations suggest the urgency of a much more qualified and extended interest in the leprosy problem than prevails at the present time. It is twenty-two years since the first leprosy conference was held in Berlin, which was followed by the Bergen conference in 1909, and it is nearly fourteen years since the great National Leper Conference was held in the Argentine Republic. The report on that conference, by Dr. Carlos G. Malbran, constitutes an invaluable source of trustworthy in- formation amplified by interesting maps illustrating the relative frequency of leprosy occurrence in the sections of the Argentine Republic most affected by the disease. Geographical Distribution in Brazil Another valuable report on the geographical distribution of leprosy in South America has been made by Dr. Carlos Da Costa Ribeiro under date of May, 1918, to the Secretary of the Interior and Justice of Brazil. This report includes a map illustrating the distribution of leprosy through- out the State of Ceara for the year 1918, indicating the unsuspected fre- quency occurrence of the disease, made even more suggestive by a map of the city of Fortaleza, showing the distribution of existing cases through- out the entire community. Urgency of a Broader National Interest Conferences and reports of this kind are in marked contrast to our own indifference to a subject which should arouse the medical, general scien- tific, and himianitarian interests in all who are concerned with problems of health and human welfare. For a time the United States Public Health Service published an important series of special reports on the results ♦Conforenca Sobre la Lepra, Buenos Aires, 1908. 20 of the work at the leprosy investigation station in Hawaii, but apparently in recent years little has been done that is entitled to special consideration. There is an immense mass of information which has not been subjected to critical analysis or brought within the reasonable compass of a report readily within the understanding of those who are seriously concerned with the question as to whether the disease is actually on the increase in this country and the enhanced risk of its introduction from abroad. Recent Cases of Leprosy Throughout the United States Without enlarging further, for the time being, upon the international aspects of leprosy occurrence, there is presented here a smnmary statement of the cases of leprosy reported in this country since April, 1916*. This formidable list of about 250 cases can not be considered complete or free from unavoidable duplications. The reports of the United States Public Health Service give no indication whatever as to the personal facts of most of the cases, so that one report can not be checked by another. It would be very desirable if in every case the Public Health Service would give the initials of the patient and, if possible, some very simple data as to the nativity and racial origin, the age and sex, and the type of the disease. Urgency of a More Qualified Professional Interest The reports emphasize the need of a better knowledge regarding the diagnostic indications of leprosy if serious errors are to be avoided. Reference may here be made to an article in the Brazilian Archives of Medicine for November, 1918, on incipient leprosy, in which Mourao described, with illustrations, what he calls "A New Sign of Leprosy," the details of which are set forth in a brief article in the Journal of the American Medical Association. If there is much need of better diagnosis, there is the utmost urgency for a better understanding of the exact facts of leprosy occurrence on the part of the general public. It is unfortu- nately true that many of the cases reported are set forth in sensational terms, causing undue alarm on the part of those who can not possibly be expected to understand the essential facts of a disease which, fortunately, is still of rare occurrence in this country. Conversely, however, there is as much danger in underrating the importance of isolated cases, as, for illustration, in the statement by the late surgeon-general of the United States Public Health Service with reference to the Early case, that "though leprosy is a disease to be dreaded it is not a national menace" in the same sense that venereal diseases, etc., are, which, though true, leads neverthe- less to erroneous conclusions on the part of the general public.f Leprosy- is a serious menace to this nation and, however much guarded against by modern methods of sanitary living and sanitary precautions, it is a danger to any one and all who may have the misfortune to come in contact, know- *Most of these cases are from the weekly Sanitary Reports of the United States Public Health Service. tSee footnote on page 13. 21 ingly or unknowingly, with patients suffering from the disease from its incipient to its terminal stage. I can not do better than quote in this con- nection from a cable despatch to the New York Sun, dated Honolulu, November 11, 1919, a part of a pitiful story of a white woman recently apprehended as a leper, and now, and probably for the remainder of her life, at Molokai. This woman was the daughter of a former minister of foreign affairs under King Kalakaua. She had been a leper since she was five years of age, had been taken to Japan, but later on had been returned to her mother's home, where she lived and was cared for until her mother's death, when she was apprehended by the authorities and deported in accordance with the law. Such cases occur every now and then in Hawaii, clearly illustrating that the danger of disease transmission is not limited to the lower class native element or to the foreign-born. Cases of Leprosy in the United States Reported Since 1916 Location and Date Reported Remarks Baltimore, Md., April 13, 1916. Dr. M. S. Rosenthal reported a colored boot- black afflicted with leprosy at Mercy Hos- pital. Included in his report is the state- ment that, "This case well illustrates the urgent need of a national leprosarium, where these unfortunates can find a permanent refuge and the community be spared the presence of an unsightly, mutilated and incurable human being awaiting the final call." New Orleans, La., April 15, 1916. April 29, 1916. Lake End, La., April — , 1916. Boston, Mass., April — , 1916. New York City, May 6, 1916. .Tune 3, 1916. Mansfield, La., June — , 1916. Minneapolis, Minn., June — , 1916. rous symptoms began during explosion in 1911. No history San Francisco, Calif., July 15, 1916. July 15, 1916. Los Angeles, Calif., July 15, 1916. White Fish, Mont., July — , 1916. Boston, Mass., Aug. 11, 1916. Bellingham, Wash., Aug. 19, 1916. New Orleans, La., Aug. 19, 1916. Yokohama, Japan, Aug. 22, 1916. Galveston, Texas, Aug. 26, 1916. Los Angeles, Calif., Aug. 26, 1916. San Francisco, Calif., Sept. 2, 1916. Sept. 30, 1916. New Orleans, La., Sept. 30, 1916. Oct. 7, 1916. Seattle, Wash., Oct. 7, 1916. One case. Negro woman. Native of Harput, Turkey. Sent to Penikese Island. One case; one death. One death. Colored male. Chinese, native of Otage, Japan, in United States nine years. Lived in Montana until he came to Minneapolis, March 7, 1916. Lep- convalescence from severe burn due to gasolene of leprosy in patient's family. American, had come from Denver four years previously. Left for Louisville, Ky., June 7, 1916. One case. Chinese. Cuban student, removed to Penikese Island. A Greek who had been in the United States more than three years. Two cases reported. Twenty-five cases of Americans ivith leprosy reported in different parts of Japan. One case. Two cases. One case. 22 Location and Date Reported Remarks New Orleans, La., Oct. 14, 1916. One case. Milwaukee, Wis., Nov. 2, 1916. Greek. Los Angeles, Calif., Nov. 11, 1916. One case. New Haven, Conn., Nov. 20, .1916. Case reported by Dr. John E. Lane, con- firmed by Dr. C. J. Bartlett, of the Yale Uni- versity Medical School. It is said in this connection that: "The chief interest in this case is the illustration of the fact that leprosy patients wander about for a long time without being recognized, as a majority of the physicians have never seen a case of the disease, and quite naturally do not suspect it." New Orleans, La., Nov. 25, 1916. New York City, Nov. 25, 1916. Newark, N. J., Dec. 2, 1916. New York City, Dec. 2, 1916. Ansonia, Conn., Dec. 9, 1916. Indianapolis, Ind., Dec. 10, 1916. San Francisco, Calif., Dec. 12, 1916. Dec. 16, 1916. Fort Branch, Ind., Dec. 21, 1916. Williamsport, Pa., Dec. 30, 1916. Oakland, Calif., Dec. — , 1916. New Orleans, La., Dec. — , 1916. San Francisco, Calif., Jan. 13, 1917. Jan. 20, 1917. New York City, Feb. 3, 1917. Jersey Citv, N. J., Feb. 10, 1917. New Orleans, La., Feb. 10, 1917. Los Angeles, Calif., Feb. 10, 1917. New Orleans, La., Feb. 17, 1917. San Diego, Calif., Feb. 17, 1917. Milwaukee, Wis., Feb. 21, 1917. San Francisco, Calif., Feb. 24, 1917. Jersey City, N. J., Feb. — , 1917. New Orleans, La., (Parish) Feb. — , 1917. March 3, 1917. New York City, March 17, 1917. San Francisco, Calif., March 24, 1917. Springfield, Mass., May 10, 1917. Richmond, Contra Costa Co., Calif., May 14, 1917. Oakland, Calif., May 17, 1917. Los Angeles, Calif., May 26, 1917. New Orleans, La., May 26, 1917. New York City, May 26, 1917. Los Angeles, Calif., June 9, 1917. Klamath Falls, Ore., June 14, 1917. New York City, June 16, 1917. Burtville, E. Baton Rouge Parish, La., June — , 1917. Los Angeles, Calif., July 13, 1917. Collaborating Epidemi- the Connecticut State One case. Two cases. Syrian. One case. Case reported by ologist Black, of Board of Health. Naval veteran of the Civil War. Case diag- nosed by a young interne — Dr. C. V. Kemp — at Long Hospital, who had never previ- ously seen leprosy. One case. Native of Indiana, but formerly lived in Alaska, Mexico, and Panama Canal Zone. One case. Three cases. Two cases. One case. Mexican, transferred to Los Angeles County Hospital. One case. Three cases notified during the month. One case. Syrian, who had escaped from City Hos- pital, Newark, N. J., largely because of in- adequate precautions and otherwise un- suitable surroundings. One case. Chinese case. Mexican. Two cases. One case. Hawaiian case. Italian, formerly living in Spokane. One case. Negro. Japanese woman, resident for about one year. 23 Location and Date Reported Remarks Phillipsburg, N. J., July 17, 1917. Two cases, originally discovered on Black- well's Island, N. Y. Children of a woman, also a leper, whose cause of death had been certified as embolism, although the symptoms were similar to those of the dis- ease in the children. (See also Newark Evening News, April 12, 1918.) Los Angeles, Calif., July 21, 1917. New York City, July 26, 1917. Syracuse, N. Y., Aug. 17, 1917. White Pine County, Nev., Aug. 17, 1917. Garyville, St. John Parish, La., Aug. — , 1917. Providence, R. I., Sept. 14, 1917. New Orleans, La., Sept. 29, 1917. San Francisco, Calif., Oct. 13, 1917. Biloxi, Miss., Oct. 18, 1917. Alberton, Mont., Oct. 19, 1917. San Francisco, Calif., Oct. 27, 1917. Nov. 10, 1917. New Orleans, La., Nov. 17, 1917. Williamsport, Pa., Nov. 19, 1917. Galveston, Texas, Dec. 1, 1917. Bennettsville, S. C, Dec. 15, 1917. Long Beach, Miss., Dec. — , 1917. Jersey City, N. J., Jan. 30, 1918. Portland, Ore., Feb. 9, 1918. New Orleans, La., Feb. 16, 1918. Feb. 23, 1918. Jersey City, N. J., Feb. 25, 1918. One case. Greek, who came to United States in 1913. Two cases reported, brothers, natives of Greece, formerly residents of New York City. (One of these escaped August 15, be- cause of inadequate precautions.) One case. Father and three brothers of this patient had previously been sent to the State Lepers Home. Native of Italy, resident of this country five years. One case. This man was employed as oyster shucker when discovered, having followed that occu- pation for past six years. One case. Sicilian, in United States eleven years. Isolated outside of city. One case. Native and former resident of Louisiana. Native of Germany, formerly a resident of Brooklyn, who died by suicide day following. One case. Negro woman from West Indies. This was the third case for some time past reported to local authorities, one having been a Mexi- can, and second case, also apparently a foreigner, who committed suicide. West Haven, Conn., Feb. — , 1918. Galveston, Texas, March 2, 1918. Oakland, Calif., March 2, 1918. New Orleans, La., March 9, 1918. March 13, 1918. March 23, 1918. Los Angeles, Calif., March 23, 1918. San Francisco, Calif., March 23, 1918. Los Angeles, Calif., April 9, 1918. April 13, 1918. San Francisco, Calif., April 20, 1918. Riverside, Calif., April 23, 1918. Louisville, Ky., April 27, 1918. Philadelphia, Pa., April 29, 1918. Boston, Mass., May 7, 1918. New Orleans, La., May 25, 1918. Rio Vista, Calif., May — , 1918. One case. One death. Native East Indian. One case. Native Hawaiian, age the islands 3^ years. 14; had lived in 24 Location and Date Reported Fresno, Calif., May — , 1918. San Francisco, Calif., May — , 1918. Abilene, Texas, June 8, 1918. Bridgeport, Conn., June 8, 1918. New Orleans, La., June 8, 1918. June 29, 1918. Alexandria, La., June 29, 1918. Boston, Mass., June 29, 1918. June — , 1918. Bridgeport, Conn., June — , 1918. Avoyelles Parish, La., June - — , 1918. Oakland, Calif., July 13, 1918. July 27, 1918. Mandeville, La., July — , 1918. New Orleans, La., July — , 1918. Oakland, Calif., July — , 1918. Boston, Mass., July — , 1918. New Orleans, La., Sept. 21, 1918. Sept. 28, 1918. Dayton, Ohio, Sept. — , 1918. Tyron, N. C, Sept. — , 1918. Boston, Mass., Oct. 29, 1918. Glendale, Ariz., Oct. — , 1918. Boston, Mass., Nov. 2, 1918. Galveston, Texas, Nov. 2, 1918.. New York City, Nov. 9, 1918. New Orleans, La., Nov. 13, 1918. Nov. 16, 1918. Los Angeles, Calif., Dec. 21, 1918. Feb. 2, 1919. Braddock, Pa., Feb. — , 1919. New Orleans, La., March 8, 1919. San Francisco, Calif., March 8, 1919. Philadelphia, Pa., March 15, 1919. District of Columbia, March — , 1919. Galveston, Texas, April 19, 1919. Philadelphia, Pa., April 21, 1919. New Orleans, La., April 26, 1919. San Francisco, Calif., April 26, 1919. April — , 1919. Remarks Two cases; one a native woman of Mexico, and one a Chinaman, of Louisiana. Chinaman, resident in United States eight years. One case. Two cases. One a native of China, and one a Russian. Greek, resident of United States for past four years. One case. Transferred to Louisiana State Leper Colony. One case. Two cases. One case. Two cases. Chinamen; natives of Hawaii, possibly previously reported from other lo- calities. Two cases. One from nearby state, sent to Penikese Island. One case. Two cases. Greek, formerly resident of Columbus, Ohio. Famous Early case. Early had escaped from Washington, D. C. Native of Cape Verde Islands. Native Mexican. One case. One death. One case. Native of Philippine Islands. One case. One case. Patient died of smallpox, March 22, 1919. White woman, life-long resident of Galves- ton. Syrian, reported as having disappeared, probably with intention to reach New York. Peddler, apparently same case as reported from Springfield, Mass., and Newark, N. J. One case. Died. Native Californian who had never been out- side the State, being one of three cases known to have been contracted, without question, in California. Case reported by Dr. Howard Morrow, of San Francisco. Stockton, Calif., April — , 1919. Native of Stockton, whose brother is sus- pected of being a leper, and whose father had leprosy at the time of his death in 1912. 25 Location and Date Reported Hartford, Conn., April — , 1919. New Orleans, La., May 3, 1919. New York City, May 3, 1919. Philadelphia, Pa., May 3, 1919. Portland, Ore., May 3, 1919. Monte Rio, Calif., May 4, 1919. San Francisco, Calif., May 8, 1919. Boston, Mass., May 10, 1919. New York City, May 10, 1919. San Francisco, Calif., May 10, 1919. Boston, Mass., May 24, 1919. San Francisco, Calif., May — , 1919. El Centro, Calif., May — , 1919. San Francisto, Calif., June 7, 1919. Los Angeles, Calif., June 10, 1919. June 14, 1919. Baltimore, Md., June 14, 1919. New Orleans, La., June 21, 1919. Philadelphia, Pa., June 21, 1919. Orleans Parish, La., June — , 1919. St. Martin Parish, La., June — , 1919. Contra Costa County, Calif., June — , 1919, New Orleans, La., July 12, 1919. Boston, Mass., July 14, 1919. San Francisco, Cailf., July 26, 1919. July — , 1919. Santa Rosa, Calif., July — , 1919. LaFayette, La., July — , 1919. Olympia, Wash., July — , 1919. New Orleans, La., Aug. 2, 1919. Sacramento, Calif., Aug. 16, 1919. San Francisco, Calif., Aug. 16, 1919. Lansing, Mich., Aug. 30, 1919. New York City, Aug. — , 1919. Galveston, Texas, Aug. 30, 1919. Otero County, Colo., Aug. — , 1919. Beloit, Wis., Sept. 6, 1919. Benton Harbor, Mich., Sept. 6, 1919. Los Angeles, Calif., Sept. 6, 1919. New York City, Sept. 13, 1919. New Orleans, La., Sept. 13, 1919. Los Angeles, Calif., Sept. 27, 1919. San Francisco, Calif., Sept. 27, 1919. Oct. 4, 1919. Los Angeles, Calif., Oct. 11, 1919. Houston, Texas, Oct. 18, 1919. Boston, Mass., Nov. 1, 1919. Los Angeles, Calif., Nov. 1, 1919. New York City, Nov. 1, 1919. Pueblo, Colo., Nov. 1, 1919. New Orleans, La., Nov. 8, 1919. San Francisco, Calif., Nov. 8, 1919. Ann Arbor, Mich., Nov. 13, 1919. Los Angeles, Calif., Nov. 22, 1919. New Orleans, La., Nov. 22, 1919. Charlotte, N. C, Nov. 29, 1919. Remarks Native of Trinidad, West Indies, formerly resident of Providence and Boston. One case. Chinaman, born in San Francisco. Mexican. One case. Two cases and one death. One case. (Patient escaped to Mexico.) One case. One case. Mexican. One death. One case. One death. Two cases. One case. Case reported of a leper who escaped from the Detention Hospital, subsequently appre- hended in Philadelphia. One case. Mexican male. Formerly resident of Hawaii. One case. One case. Formerly U. S. soldier who had been in service in Philippines. One case. One death. One case. Native of Porto Rico. One case. One case; one death. One case. Two cases. One case. One death. One case. One death. One case. Two cases. One case. 26 Location and Date Reported Remarks St. Joseph, Mo., Nov. 29, 1919. One case. , r^ r^ Cambridge, Wis., Nov. — , 1919. Second case reported in State, by Ur. Cor- nelius A. Harper, of Madison. Chicago, 111., Nov. — , 1919. One case. Pinos Altos, N. M., Nov. — , 1919. La Junta, Colo., Dec. 6, 1919. Mexican. Galveston, Texas, Dec. 6, 1919. One death. , . x Ann Arbor, Mich., Dec. 13, 1919. One case. (Possibly previously given.) Christiana Wis., Dec. — , 1919. One death. (Originally diagnosed June 3, 1919.) Boston, Mass., Jan. 22, 1920. One case, formerly of Rome, N. Y. Worker in chocolate factory. Tilden, Neb., Jan. 29, 1920. Spanish War veteran. Boston, Mass., Jan. 31, 1920. Second case reported withm fortnight; ce- ment worker from Baltimore ; sent to i eni- kese Island. San Francisco, Calif., Jan. 31, 1920. One case. , ^, , , ^ . Dayton, Ohio, Feb. 29, 1920. According to the Cleveland Leader, case being cared for at present time at Day- ton. A Greek, whom it is proposed to re- turn to his native country. Stated in same dispatch that there had been a leper in same locality — Mexican— who had escaped several months ago. New York City, March 7, 1920. According to Bronxborough Netvs of March 7th there are at present time 22 cases of known leprosy in New York City, subject to practically no restrictions or supervision, being allowed to walk about the streets of the city on the assumption that "the disease can not develop in this climate. This, of course, is a serious error, for leprosy develops in any climate and under any conditions of life, as far as known, where there is exposure to existing cases, or contact, since the disease is known to be transmissible, although the exact method of transmission remains a mystery.* Muskogee, Okla., March 13, 1920. A negro suspect escaped from Coffeyville, Kans., was apprehended by local health authorities. Lansing, Mich., March 26, 1920. One case. Native of Lansing. New Orleans, La., April 15, 1920. Two cases. Found by city health officials while awaiting "treatment" at the hands ot a faith healer. Need and Value of a National Leprosy Conference The preceding list of cases should arouse the interest of an indifferent public, an indifferent medical profession, and a public health service far from being as active as the needs of the present situation demand. Whether leprosy is actually on the increase or not is secondary to the question that the disease occurs with a sufficient degree of frequency throughout prac- tically the whole United States to demand a change from public apathy, little short of a crime. Other countries, in which a much lesser number of cases occur, make adequate provision and render adequate reports with a reasonable assurance that measures of control are more effective than they are apparently in this country at the present time. The example of Argen- tina may well be followed in this country, for only a national conference thoroughly representative of all the interests concerned can arouse the American public to a danger that confronts future generations if new endemic centers are allowed to be created. It is not a problem for a ♦The actual number of cases in New York City at the present time i« 28. 27 city or a State to solve, but a matter of the utmost national and interna- tional concern. Much good unquestionably resulted from the international leprosy conferences of 1897 and 1909, and a similar conference called at the present time, even if limited to the Pan-American republics, would unquestionably prove productive of far-reaching results. But if such a congress could be made inclusive at least of the countries of the Far East, and if held in the United States, tlie best thought of the present day would be concentrated upon an agreement as to the course of procedure likely to prove most advantageous to the patient and the public directly concerned. I may in this connection direct attention to a remarkable address on "Leprosy: A New View of Its Bacteriology and Treatment," by T. S. Beauchanfp Williams, M.D., contributed to the Indian Medical Gazette for May, 1911, as an illustration of much neglected phases of the subject in this country. At the same time, I may recall an excellent outline of fundamental principles, by Dr. Isadore Dyer, set forth in an address on "The Dermatologic Aspects of Leprosy," contributed to the proceed- ings of the Sixty-fourth Annual Session of the American Medical Asso- ciation in 1913. Two years later Dr. Douglass W. Montgomery read an important address on "Illustrations of the History of Leprosy," in the sec- tion on dermatology, of the American Medical Association, San Francisco, 1915, and many of those present were given the privilege of observing actual cases of leprosy, brought down to the meeting from the Isolation Hospital of the city. The paper by Dr. Montgomery was increased in value by a report of cases with observations on "Symptoms and Diagnosis of Leprosy," by Dr. Howard Morrow and Dr. A. W. Lee, of San Francisco, clearly illustrating that in its scientific aspects the disease is not being neglected in this country. Nor must I omit to refer by title to an address on "The Etiology and Treatment of Leprosy," by Dr. Ernest Dwight Chip- man, read at the same meeting, which will always represent a milestone in the progress of the study of a subject which, on account of the rarity of the disease, is perhaps one of the most diflfiicult problems of modern medicine. Medical and Dermatological Aspects of Leprosy Regardless of the advances which have been made during recent years, we are still far behind in the adequate consideration of questions of etiology, diagnosis, and treatment based upon the actual experience which has been had in this coimtry and which unquestionably, in important mat- ters of detail, differs from the experience in large endemic leprosy centers abroad. This point of view is perhaps best illustrated by reference to the extremely interesting report on the treatment of leprosy, by Dr. F. Hall, superintendent of the leper asylum at Makogai, Fiji Islands, and the admirable statistical analysis of 10,000 cases of leprosy at the Culion Leper Colony, Philippine Islands, by Dr. Oswald E. Denney. This paper is of special interest if read in connection with the observations on the treatment of leprosy in the Philippine Islands, by Dr. Victor G. Heiser, 28 - - 1 . - iiigggggs^^g^o \ ? 1 1 1 1 ^ 1 1 ' 1 ^ / ■'j^ 1 r w - 1 ^■ \ 1 ' -r, / / ^ / "i.« / / / S' ^ IPS ri ! / ■"s v / '^ y 1 (t IN y ^ ^■^ lO Ci N.»fj y _,\ j s / It / \ \ v .o> y 1 ^1 ^ ^ \ ( \ \ ^\ "" y w 5^c> r ps i; - — - ^~" — — "^ ^ tv llll"' « ! \ ■•~^^ / ) / II II / 5i cs / ---* ^ fS i ■^ ■~- \ 1 1 ■1 X y ^^^ r ^ 1 — ^s \ ■> ^ ^JJllM* 1 - Illtllll ^^ — ^ / S >< ^ ■-^ / N \ •' :^ — — — — — :rr: p ^3. -:^ ^ ~\ k ::i^ — ^r — Ri ~"-~ -~. ' \ _,,- 'v^ k S - \ 1 ^ V /. ?: < |g§28gS&§S^RS2 0^ formerly the director of health and a surgeon of the United States Public Health Service (1914). The scientific study of the subject would be very much enhanced if more detailed reports were made of the cases under observation throughout the country, but particularly in the larger centers like Louisiana, Massachusetts, California, and Molokai. The best illustra- tions of the proper method of reporting on existing cases are the annual reports on leprosy in New South Wales, including an annual review with observations of all cases at the colony at Little Bay since 1883. Such a tabular analysis for Hawaii would make an extremely interesting con- tribution to knowledge and possibly aid in the solution of a problem which thus far has failed to meet the exacting requirements of modern scientific research. iThe New South Wales reports give tlie name (by initials), the sex, nativity, occupation, date of, and age on admission, locality where disease was probably contracted, number of the case, clinical notes, and the date of death or discharge. The clinical notes describe in detail, though with the required brevity, the history of the illness, the conditions on admission, differentiating the parts of the body, and finally, notes on the progress of the disease and the treatment, presenting in brief a rea- sonably complete picture of the cases under treatment, amplified by notes on the examinations of material for leprosy bacilli carried out by the microbiological laboratory of the department of public health. Present Status of the Federal Leprosarium It would be utterly impossible to attempt, within the necessary limita- tions of time, the presentation of the essential facts of leprosy occurrence throughout the world, although an abundant amount of extremely valuable material is available for the purpose. The hope that the leprosy investi- gations at the United States station at Molokai would very materially increase our knowledge of the disease from its incipient to its advanced stage has not been realized. But even more lamentable is the long delay in the establishment of a federal leprosarimn in accordance with the act of Congress of February 3, 1917, although it may be said that the outlook at the present time is somewhat more hopeful that such an institution will shortly be established, though possibly not in a locality entirely suitable for the purpose. I am able to conclude this address with a letter from the Acting Sur- geon General of the United States Public Health Service, dated March 10, 1920, who in answer to an inquiry as to the present status of the leprosarimn question, replied as follows: "In reply to your letter oi March Sth requesting information as to the present status of the Federal Home for Lepers, I have the honor to inform you that the Board hopes to begin construction within a short time. As you know, the Surgeon General appointed a Board of which you were a member to assist in the selection of a site. TTiis Board made a careful and comprehensive survey of all available sites in all sections of the United States and decided that the best and most suitable site for the Federal Leprosarium would be on the three islands known as Snake Key, North Key and Sea Horse Key, lying in the Gulf of Mexico off Cedar Keys, Florida. The Board 30 80 recommended to the Surgeon General who approved their findings and forwarded them to the Secretary of the Treasury with a request that the transfer of these three islands be requested from the Department having jurisdiction. In accordance with the request of the Secretary of the Treasury the Secretary of War on September 5th transferred Snake Key and North Kev for the purposes of a leprosarium disclaiming jurisdiction of Sea Horse Key ^vhich had been set apart for light house purposes on September 25, 1851, and was therefore under the jurisdiction of the Department of Commerce. A Department letter addressed to the Secretary of Commerce asking for permission to use and occupv Sea Horse Key for the proposed Federal Home for Lepers was favorably answered by the Secretary of Commerce on September 19, 1919 "As might be expected the selection of a site for a leprosarium in any state would develop some opposition. The entire Florida delegation accompanied the Governor of Florida in a \isit of protest to the Surgeon General on October 23rd, 1919. The opposition locally, however, is largely the development due to the activity of one man, and through a very active propaganda instituted by him throughout the state. "Since that time Government representatives have been able to present the facts to the people of Florida and a very strong sentiment has developed for the establish- ment of the leprosarium on the site named above. _ _ "Owing to the popular fallacy concerning the danger of leprosy it is not to be expected that less opposition will he encountered in any state and in all probabilities the Department will go ahead -^vith the construction of the Federal ^Home for Lepers upon the three keys named in the vicinity of Cedar Keys, Florida." Importance of Accurate and Complete Leprosy Statistics The question of leprosy increase and the adequate federal care and proper treatment of lepers is, therefore, one of the near future, being largely dependent upon an aroused public, professional and governmental interest. Leprosy at the present time may possibly have reached a more or less stationary condition in this country, but it is not to the credit of our civilization that the frequency of the disease should not be actually on the decrease. The apparent increase can not be charged exclusively to the foreign element, which can not if leprous be kept out by even the most rigid quarantine examination, but, as shown by the experience in Louisiana, for at least one hundred years, the disease has gradually been gaining in frequency until a number of endemic centers now exist as to which the public at large is rightfully entitled to more trustworthy information than is at present available. According to the reports received from health officials all over the country, there are at present not less than eighty-seven cases in Louisiana, thirty-nine cases in California, thirteen cases at the Penikese Colony of the State of Massachusetts, twenty-eight cases in the city of New York, five cases in Connecticut, ten cases in Minnesota, and thirty-three cases in Texas. There are sufficient reasons for believing that the number of known cases probably represents less than one-half of the actual number of cases in this country at the present time, and, restating the estimate previously arrived at, which unquestionably falls short of the whole truth, the probable number of cases of leprosy in this country at the present time is not less than 400. The situation is therefore a most serious one, which it is the duty of the Government to consider with a lesser degree of indifference than has been the case in the past, and more so in view of the liberality of Congress in providing adequately for the establishment of one federal leprosarium, which it is hoped will in time 31 be followed by two or three others, as the only hope of dealing effectively with the question of proper segregation and control. It is the firm belief of those who are best in a position to judge, that only by means of such segregation can the frequency of the disease be reduced — at least this has been the experience at Tracadie in New Brunswick, at Bergen in Norway, and at Molokai in Hawaii. Nothing could be more wrongful than to arouse an unnecessary alarm on the part of the general public, for the actual danger of an extensive spread of the disease is slight, but whoever has seen even one case of leprosy, and I personally have seen more than two thou- sand, can not but feel a sense of profound personal obligation that noth- ing should be left undone so that this most unfortunate element of our population may be better cared for in a medical as well as in a humane sense, than is the case, unhappily, at the present time. Summary of Conclusions On the basis of the best possible information it may therefore be con- servatively estimated that there are not less than 250 known cases, and probably from 400 to 500 known and suspected cases of leprosy throughout the continental United States at the present time. This estimate is more conservative than earlier assimiptions, but the available evidence would seem to justify the conclusion that the disease is very slowly increasing in this country and that new foci of leprosy are being formed and as such constitute a serious menace to the public health interests of the nation as large. Under date of February 3, 1917, or more than three years ago, Con- gress enacted a bill providing the sum of $250,000 for a federal lepro- sarium, chiefly for the care of interstate and international lepers. It is regrettable that there should have been so much delay in establishing a model federal institution, but the outlook seems fairly hopeful that the site selected at Cedar Keys, Florida, will meet with public approval. Whether it is the best site that could have been selected is open to question. It was recommended that the Government use the Ship Island quaran- tine station, which has been abandoned for other purposes, and could have been utilized at very small expense practically for the immediate accom- modation of isolated cases of leprosy throughout the South. The question is pertinent why such a site, in all respects admirable for the purpose, should go to waste when the situation is most urgent and in fact in some cases a desperate one. The first leper home in this country was established by the State of Louisiana in 1894 near Carville, on the Yazoo and Mississippi Valley Rail- way, near a point in Iberville Parish, La., known as Bruns, about sixty miles from New Orleans. That institution has about one hundred inmates and is under the medical supervision of Dr. Ralph Hopkins, of New Orleans, and a board, of which Dr. Isadore Dyer is a member. At the Louisiana institution about eighty per cent, of the lepers cared 32 for are white, whereas the white population of the State is only fifty-seven per cent. Whether this would justify the conclusion that leprosy is rela- tively more common among the white than among the colored population is somewhat doubtful, for negro cases are probably more effectively secreted than white cases. The average age on admission was thirty-two years for white males and forty years for colored males. For females the average age on admis- sion was thirty-seven years for white patients and thirty-eight years for colored patients. It would therefore seem fairly safe to conclude that the average age on admission is somewhat higher for colored lepers than for white lepers. Of the total number of cases now under observation at the Louisiana Home, about thirty per cent, are of the tubercular variety, twenty-four per cent, of the anesthetic variety, and thirty-seven per cent, of the anesthetic and tubercular varieties combined. The age period of greatest frequency on admission was 20-29 years. The average length of treatment previous to death is from about eight to ten years. The duration varies with different types of the disease, being longest in anesthetic cases and shortest in tubercular cases. For most of the elements of the leprosy problem the data are only gradually becoming available. In the report of the Senate Committee on Public Health and National Quarantine is included a large amount of international information, some of which has been brought down to date for the present purpose and is included in Appendix B to this address. Unfortunately our information regarding leprosy in the States in which the disease is fairly cornmon is far from complete. According to the most trustworthy recent returns the number of known ca.ses of leprosy in Louisiana is eighty-seven; in California, thirty -nine; in Massachusetts, thirteen; in Minnesota, ten; in New York City, twenty-eight; in the State of Pennsylvania, six; in Texas, thirty-three; while isolated cases are known to occur in probably ten to fifteen more States at the present time. In the registration area, which now includes about eighty per cent, of the total population of the United States, there have occurred during the last ten years 120 deaths from leprosy. The recorded mortality rate has increased from 0.13 per million in 1900 to 0.29 in 1918. If the death rate of 1918 is taken as 0.3 per million, the number of probable cases in the continental United States may be conservatively placed at 400. This does not represent the cases officially noted during the lifetime of all the lepers, or effectively segregated, or subject to government supervision and control, but rather the assumed number of cases which give rise to the mortality indicated on the basis of the probable known death rate of lepers under segregation, placed as high as 80 per 1,000 per annum. The discussion includes a statement in detail of nearly 250 reported cases of leprosy throughout the continental United States during the period April, 1916, to April, 1920. The list clearly emphasizes the menace to the American nation of a deplorable attitude of public apathy and neglect. 33 It was the evidence presented to the Senate Committee on Public Health and National Quarantine which resulted in the passage of a bill providing for a federal leprosarium. One institution will meet an emergency but will only in part aid in the solution of the problem. Three institutions are cer- tainly required, and possibly four; there should be one on the Gulf Coast, one on the Pacific, one on the Atlantic, and one in the Central West. The institutions now maintained by the State of Massachusetts at Penikese Island, Buzzard's Bay, by the State of Louisiana, by the City of San Francisco at the Isolation Hospital, and by certain other commimities in connection with public institutions, meet only the most urgent needs of a situation not far from desperate. It is to be hoped that the Public Health Service wilj more actively concern itself in the future with the provision of the act of Congress, which, though not mandatory, is certainly equiva- lent to a request that all unnecessary delay should be avoided. There is leprosy to the north of us in New Brunswick and British Columbia; there is leprosy to the south of us in the West Indies and Cen- tral America, the Panama Canal Zone, and throughout a large portion of South America; there is leprosy to the east of us in European countries such as Greece, Bulgaria, Syria, Scandinavia, Northeast Germany, Russia, Turkey, etc. ; and there is leprosy on an immense scale to the west of us in Hawaii, the Philippines, Japan, and throughout the farther East. Only a grossly indifferent public opinion can account for our national apathy towards a question which has been a subject for discussion in the medical press and otherwise for over fifty years. There are perhaps one hundred cases in the Panama Canal Zone, there are over six hundred cases in Hawaii, there are over five thousand cases in the Philippines, and through- out the world possibly not less than three million cases, a potential menace at least to every other country indifferent to its interest and in our own case from the fact that leprosy in the United States occurs often in isolated in- stances, one and all of which can be traced to some locality where leprosy is known to exist. It may therefore be suggested that this question should receive more adequate consideration in the future and that pressure should be brought to bear upon the public health authorities, the Federal Government, and the several States to deal more effectively and humanely with leprosy cases now known to occur. It may further be suggested that the time is opportune for another leprosy conference in continuation of the inter- national meetings held in Berlin in 1897 and in Bergen, Norway, in 1909, and of the corresponding national conference held in the Argentine Republic in 1906."' Such a conference would bring together the best thought of the present period in behalf of the solution of a problem which is an indictment of our civilization and most of all of our indifference to the humane interests and the personal welfare of the most afflicted portion of mankind. ♦For important observations on previous leprosy congresses see the Journal of the American Medical Association, April 4, 1896, February 20, 1897, and November 13, 1897. Also the report by Sir Arthur Newsholme and Sir Malcolm Morris at the International Conference of 1909. (Parliamentary paper, Cd. 4916, London, 1909, P. S. King & Son, London.) 34 APPENDIX A Leprosy in India There is no more fruitful field for the statistical study of leprosy than the vast Indian Empire, for which admirable census reports have been published for a long period of time. These reports amplify the large amount of useful information contained in the report of the Leprosy Com- mission (Calcutta, 1893). According to the census of India for 1911 (Cal- cutta, 1913) the proportion of lepers to population was 50 males and 18 females per 100,000 of each sex. Of the different provinces of India, Assam suffers most, then Burma, then, in order, Bihar and Orissa, the Central provinces and Berar, Madras, Bengal, Bombay, the United pro- vinces, the Punjab, and the Northwest Frontier provmces. In the last two provinces the proportion of lepers was 17 males and 8 females per 100,000 of population of each sex. It is observed in the report referred to that "the physical and climatic characteristics of the tracts where leprosy is most prevalent differ greatly. In some of these tracts the climate is dry and the rainfall light, while others have a damp climate with heavy rain- fall. Some of them are alluvial river valleys, while others have a laterite or rocky soil. Some are low-lying, others are slightly elevated, and others again are in mountainous country. The races who inhabit these areas also vary greatly, and they subsist on different kinds of food." Throughout India the ratio of male lepers is far in excess of the cor- responding ratio of females. It is pointed out, however, that while it is possible that males are more susceptible to the disease than females, it is very improbable that this is the case to the extent indicated by the census figures. For it is held that "the great disproportion which they show is no doubt due largely to the fact that the disease is concealed wherever possible, and that women are more successful than men in evading the inquisitiveness of the enumerators." As regards the incidence of age, it is stated that "imder the age of 10 the proportion of lepers is exceedingly small, but it soon begins to grow. There is a considerable increase be- tween 10 and 20; and from that age up to 50 the rise is uniform and fairly rapid. Between 50 and 60 the proportion continues to increase slightly, and then declines. Bearing in mind the fact that a leper's life is a comparatively short one, it would seem that the greatest liability to the disease occurs between the ages 20 and 50." The occurrence of leprosy according to caste is an extremely complex problem which cannot be dealt with briefly on account of the (to us) practi- cally meaningless designations of castes for which there is no equivalent in English-speaking countries. Those who care to examine into the subject from this viewpoint should consult the handbooks for the Indian army describ- 35 ing the different principal castes in India, published by the government printing office, Calcutta. It is stated in the census report for 1911 that "the low castes suffer more from leprosy than the high." This greater liability-, it is explained, of the lower castes, "may be ascribed to their povertv, and to the small, insanitary, and often dirty, houses in which they live." But it is pointed out in this connection, "it must be remembered that successful attempts at concealment are probably more frequent in the case of the higher castes. The proportion of Christians among lepers is exceptionally high, but this is simply because most of the asylimas are managed by missionary bodies, who make many converts amongst the unfortimate inmates." The number of lepers throughout India has decreased from 126,000 in 1891 to 109.000 in 1911, a diminution equivalent to more than 13 per cent. This decrease, it is maintained, is genuine and indicative of a real diminution in the prevalence of the disease. It is pointed out, however, that this is "partly the result of the improved material condition of the lower castes, amongst whom leprosy is most common, and of a higher standard of cleanliness." The total number of leper settlements or asylums in India, according to the census of 1911, was then 73. But these contained only some 5,000 in- mates, or not quite five per cent, of the total number of lepers. The report concludes with the following interesting observation: "The belief is growing that leprosy is communicated from one human being to another bj' some insect, and two South African doctors have recently pub- lished papers implicating the bed bug (acanthia lectularia) . If this theory be correct it is ob'sious that the segregation of lepers in asylums must reduce the number of foci of the disease, and to that extent prevent it from spreading. It is worthy of note that in many of the districts where the disease was most prevalent in 1891, there has since been a remarkable improvement. Chamba, which in 1891 had 34 lepers in everj' ten thousand of its population, now has only 15; in Birbhum the corresponding proportion has fallen from 36 to 16, in Banlcura from 36 to 23. in Simla from 29 to 18, in Dehra Dun from 20 to 11, in Garhwal from 17 to 10. in Burdwan from 22 to 14. and in North Arakan from 28 to 20." These general observations on the occurrence of leprosy throughout India are enlarged upon in the separate census reports for the several provinces. Referring first to the province of Assam (Shillong, 1912), it appears that the local rate of incidence varies between a minimum of less than 5 per 100,000 of population to a maximum of from 85 to 90. The report directs attention to the marked decline in the relative frequency of the disease, but it is not clear whether the decrease is equivalent to an actual diminution or to an improvement in the more correct diagnosis. It is said, for illustration, that the general results of the caste statistics point to the conclusion that the high proportional figures for Assam are due in a great measure to the confusion of leprosy with other corrosive or skin diseases. Of interest in this connection is a statement that "once a person is attacked 36 with leprosy, his expectation of life is considerably diminished, the aver- age period after the appearance of the disease being from 10 to 18 years." The report for Burma (Rangoon, 1912) shows an increase in the frequency of the disease, the nimiber of lepers in 1911 being 4,842 males and 2,196 females, or, respectively, 40 and 18 per 100,000 of population. The author of the report, Mr. C. Morgan Webb, directs attention to the interesting fact that there is an exceptionally low proportion of leprosy in the five sea-coast districts, and states that "this would appear to effect- ively dispose of the theory of Dr. Hutchinson that leprosy is caused by a bacillus introduced into the stomach by means of badly cured fish, eaten in a state of partial decomposition and not sufficiently cooked." It is explained in this connection that "the comparative absence of leprosy in coast districts would appear to be a stronger argument against the theory, than its presence in regions remote from seas and rivers. However the theory has not yet succeeded in receiving general acceptance. Apart from the comparative immunity of the coast districts from leprosy no rule for its general distribution by locality can be formulated. It cannot be said to be more prevalent in wet districts than in dry districts or vice versa, nor does the contour of the country or the diversity of its surface appear to have any appreciable effect on the prevalence of this infirmity." In addition to the foregoing, however, the report directs attention to the high degree of prevalence of leprosy among the Inthas, a tribe of lake dwellers of Burmese race, which seems to support the theory of Dr. Hutch- inson that leprosy is caused by the consumption of badly cooked and badly cured fish. The views of Sir Jonathan Hutchinson have been set forth in a treatise entitled "On Leprosy and Fish Eating," (London, 1906) which contains a number of very suggestive references to Burma and the Burmese type of leprosy (p. 350 et seq.). Aside from much other interesting information, the report restates the conclusions of the British and Colonial delegates to the International Con- ference on Leprosy held at Bergen, Norway, in 1909, as follows: "(1) Leprosy is spread by direct and indirect contagion from persons suffer- ing from the disease. The possibility that indirect contagion may be efifected by fleas, bugs, lice, the itch, etc., has to be borne in mind. Leprosy is most preva- lent under conditions of personal and domestic uncleanliness and overcrowding, especially w^here there is close and protracted association between the leprous and non-leprous. "(2) Leprosy is not due to the eating of any particular food, such as fish. "(3) There is no evidence that leprosy is hereditary; the occurrence of several cases in a single family is due to contagion. "(4) In leprosy an interval of years may elapse between infection and the first recognised appearance of the disease. It is a disease of long duration, though some of its symptoms may be quiescent for a considerable period and then recur. "(5) The danger of infection from leprous persons is greater when there is discharge from mucous membranes or from ulcerated surfaces. "(6) Compxdsory notification of every case of leprosy should be enforced. "(7) The most important administrative measure is to separate the leprous from the non-leprous by segregation in settlements or asylums. 37 "(8) In settlements, home life may be permitted under regulation by the responsible authorities. "(9) The preceding recommendations, if carried out, will provide the most efficient means of mitigating the leper's suffering and of assisting in his recov- ery, and at the same time will produce a reduction and ultimate extinction of the disease." (pp. 234-5.) In the provinces of Bengal, Bihar and Orissa leprosy is unusually prevalent in two well-defined centers, which contaia some 12,600 enumer- ated cases. The average rate is as high as 160 per 100,000 of population, and reaches a maximum intensity in the Bankura district, with a rate of 230. Since 1901 there has been a general decline of leprosy throughout the provinces, or for males from 72 to 62 and for females from 23 to 21 per 100,0'00 of population. The decrease is ia part ascribed to a more accurate diagnosis of leprosy and particularly to such complaints as leuco- derma and secondary syphilis, which are excluded from the returns. It, however, is held that there is no question of doubt that leprosy is gradually though slowly, becoming less common. Recalling the previous statement that a leper's life is a comparatively short one, the observation is of interest tliat "according to one of the most reliable estimates, tlie average duration of life from the date of attack is only nine and one-half years for tuberculated and eighteen and one-half years for anesthetic leprosy." Reference is made to the Lepers' act of 1898, applicable to the whole of India, which provides for the establishment of asylums to which lepers may be sent from specified areas and for the arrest of pauper lepers found wandering in such areas, and for their detention in an asylum. It also empowers the local government to prohibit lepers from engaging in cer- tain trades or occupations likely to endanger the public health. Referring to the views of Sir Jonathan Hutchinson, as regards causa- tion of leprosy among fish eating races, it is pointed out in the report that: "Mr. Hutchinson's theory is not confirmed by the results of the census over the areas where leprosy is most prevalent. In Bankura, in particular, which is the worst leper centre in either Province, the consumption of badly cooked fish is extremely rare. On the other hand, it is common among the Nepalese races, who fulfil the conditions necessary according to Mr. Hutchinson, for (1) the fish they eat is badly cured, (2) it is eaten very largely, (3) it is in a state of partial decomposition and (4) it is imported from distant places. In every bazar frequented by the Nepalese such badly cured fish may be seen. Its condition will be sufficiently described by a quotation from Mr. Inglis an old planter of North Bihar. Large quantities of dried fish are sent to Nepal, and exchanged for rice and other grains, or horns, hides and blankets. The fish- drying is done very simply in the sun. It is generally left till it is half putrid and taints the air for miles. The sweltering, half-rotting mass, packed in filthy bags, and slung on ponies or bullocks, is sent over the frontier to some village bazar in Nepal. The track of a consigmnent of this horrible filth can be recog- nized from very far away. The perfume hovers on the road, and as you are riding up and get the first sniff of the putrid odour, you know at once that the Nepalese market is being recruited by a fresh accession of very stale fish. If the taste is at all equal to the smell, the rankest witches' broth ever brewed in a reeking cauldron would be preferable. The localities where the Nepalese are found in greatest strength have little leprosy, viz., Darjeeling, where the propor- 38 tion of male lepers per 100,000 is 45, and, Sikkira, where it falls to 16. The figures for Nepalese castes, however, show that the incidence of leprosy is very low; out of 35,000 persons belonging to different Nepalese castes in Sikkim only six are lepers." In the Central provinces and Berar the local variation in leprosy in- cidence is very considerable, the average being as high as 46 per 100,000 of population. The total number of lepers in the two provinces is 7,307. It is pointed out that women seem to be attacked by the disease at an earlier age than men, and that the higher ratio of male lepers is in part accounted for by the more successful concealment of female cases, as well as by the apparently higher mortality "among leprous women who will not so readily solicit charity as men by displaying the disease in public." For Madras the local census report is unfortunately not available, nor for the province of Bombay. For the United provinces of Agra and Oudh (Allahabad, 1912) the report prepared by E. A. H. Blimt, I.C.S., contains a considerable amount of extremely interesting and suggestive data indi- cating also a wide variation in local incidence, from a minimum rate of less than 10 per 100,000 to a maximimi of over 100. The total number of lepers in 1911, including native states, was about 14,500, which compares with not quite 12,000 in 1901. The increase is equivalent to about 24 per cent. The Himalayan division has incomparably the largest number of lepers, although there is a decrease both amongst males and females, and the figures are obscured by the presence of several asylums. In marked contrast to previous observations, in this report the view is advanced that "since the life of a leper seldom exceeds twenty years, it is obvious that a very large part of any increase must be due to fresh cases." Unless the majority of cases are of the anesthetic type, it is doubtful whether the average after-lifetime of a leper would exceed twelve years. It is observed that "leprosy has at all times proved a medical puzzle; despite all the attention it has received, its causation is still unkno^vn and a cure is un- known." This statement might easily mislead those who are not aware of the fact that the causative factor, or bacillus lepra has been thoroughly identified and is easily recognized, although the form of transmission or spread of the disease still remains shrouded in mystery. Reference is made to the Lepers' act of 1898, which contains a provision that "lepers may be forbidden to follow callings connected with the preparation and sale of food, drink, drugs, tobacco and clothing, domestic service, medical practice, midwifery, washing clothes, hair cutting, shaving, or callings which necessitate the handling of food and drink: and also to bathe, wash clothes in, or take water from, certain wells or tanks or use any public carriage save a railway carriage." Finally, it is pointed out in the report that "the great majority of lepers are not and cannot be segregated." Since the total number of lepers in British territory was 14,143 in 1911, aside from 377 lepers in native states, the importance of this conclusion is obvious. 39 The Census Report of the Northwest Frontier province (Peshawar, 1912), prepared by C. Latimer, LC.S., also calls attention to the diminu- tion of the disease from an actual number of 294 cases in 1901 to 282 in 1911. Attention is directed to the excessive frequency of the disease in the hill districts and to the incidence of leprosy in the province of Kash- mir, which for 1901 experienced a rate of 72 per 100,000 for males and 36 for females. It is observed in this connection that "whether this result is to be regarded as connecting leprosy with syphilis, which is known to be common in the hills, or whether the variation is due to difference in the food eaten, it is impossible to say," for "the causes which predispose to the disease do not seem to have been accurately determined; and no cor- respondeifce could be traced between the physical and climatic character- istics, or between the race and staple diet of their inhabitants." For the native state of Travancore, the census report for 1911, pre- pared by IN'. Subramhanya Aiyar (Trivandrum, 1912), the local frequency is given as 49 male lepers per 100,000 of population, and 16 females. Since 1901 "there has been a perceptible decrease in the number of lepers, the decline amounting to 21 per cent." Attention is directed to the sudden increase in leprosy during the age period 10-20, when apparently the risk of infection is greatest. In the native state of Coorg, the report for 1911, prepared by J. Chartres Molony, LC.S. (Madras, 1912), contains no extended observa- tions on the subject of leprosy, but the statistical results show a very marked decline in relative frequency, or, for the male population from 25 per 100,000 in 1881 to 6 in 1911, while for females the rate has declined from 23 in 1881 to 4 in 1901, no rate being given for the last census year. Finally, in the native state of Baroda, according to the administration report, 1917-1918, the number of lepers treated at the asylum was 160 against 169 in 1916-17, but such figures are, however, not very trustworthy as an index of a possible diminution or increase in frequency, as is made evident by the statement that 71 patients absconded during the year under review, the question now being under consideration to wall in the asyliun to increase the difficulty of escapes.* *0n the proposed establishment of more and model leper farm colonies in India see the British Medical Journal, of December 20, 1919. 40 APPENDIX B Leprosy Statistics Table I Analysis of Leper Admissions to the Louisiana Leper Home Rates per 1,000,000 Population New Cases Calendar Louisiana Admitted each year (z) Deaths Remaining (x) Year Population No. Rate No. Rate No. Rate 1894 1,223,801 8 6.5 — — — 1895 1,250,105 18 14.4 4 3.2 — — 1896 1,276,409 3 2.4 3 2.4 22 17.2 1897 1,302,713 6 4.6 4 3.1 — — 1898 1,329,017 5 3.8 1 — 23 17.3 1899 1,355,321 2 1.5 3 2.2 — — 1900 1,381,625 7 5.1 6 4.3 30 21.7 1901 1,409,101 10 7.1 5 3.5 — — 1902 1,436,577 10 7.0 7 4.9 38 26.5 1903 1,464,053 7 4.8 9 6.1 — — 1904 1,491,529 13 8.7 2 1.3 38 25.5 1905 1,519,005 10 6.6 2 1.3 — — 1906 1,546,481 11 7.1 3 1.9 47 30.4 1907 1,573,957 8 5.1 1 0.6 — — 1908 1,601,434 8 5.0 1 0.6 47 29.3 1909 1,628,911 18 11.1 7 4.3 — — 1910 1,656,388 17 10.3 3 1.8 66 39.8 1911 1,683,864 15 8.9 7 4.2 — — 1912 1,711,340 12 7.0 ■ 4 2.3 74 43.2 1913 1,738,816 27 15.5 8 4.6 — — 1914 1,773,482 22 12.4 5 2.8 87 49.1 1915 1,801,306 23 12.8 9 5.0 — — 1916 1,829,130 22 12.0 16 8.7 103 56.3 1917 1,856,954 9 4.8 4 2.2 — — 1918 1,884,778 15 8.0 4 2.1 89 47.2 1919 1,912,602 16 8.4 5 2.6 91 47.6 1920 1,940,426 — — — — 87 44.8 (z) Actual count of cases. (x) Remaining at time Report is made : in April. Data from Biennial Reports of the Board of Control. (Incomplete records.) Table II Analysis of Admissions to Leper Home, La. For the Period December 1, 1894, to December 31, 1915 Age on Males Females Males and Admission Cases Cases Females, Cases -10 4 1 5 10-14 16 8 24 15-19 21 11 32 20-29 34 15 49 30-39 28 12 40 40-49 22 16 38 50-59 25 14 39 60-69 7 8 15 70 and Over 4 4 8 Unknown 5 2 7 166 91 257 All Ages Average Age on Admission 33.8 37.3 35.0 Data from Biennial Reports of the Board of Control for the Leper Home. 41 Table III Lepers at Isolation Hospital, San Francisco, California Rates per 1,000,000 of Population Year Ending Admissions Deaths Remaining June 30 Population No. Bate No. Rate No. Rate 1900 342,782 1 2.9 2 5.8 19 55.4 1901 350,195 5 14.3 2 5.7 21 60.0 1902 357,608 9 25.2 1 2.8 27 75.5 1903 365,021 3 8.2 1 2.7 26 71.2 1904 372,434 3 8.1 3 8.1 19 51.0 1905 379,847 . — — 4 10.5 15 39.5 1906 387,260 4 10.3 3 7.7 20 51.6 1907 394,673 — — 4 10.1 15 38.0 1908 1 402,086 4 9.9 — — 17 42.3 1909 409,499 3 7.3 3 7.3 16 39.1 1910 416,912 5 12.0 3 7.2 17 40.8 1911 424,325 2 4.7 — — 18 42.4 1912 431,738 5 11.6 2 4.6 18 41.7 1913 439,151 5 11.4 3 6.8 16 36.4 1914 446,564 4 9.0 3 6.7 14 31.4 1915 453,977 1 2.2 1 2.2 15 33.0 1916 461,390 1 2.2 2 4.3 20 43.3 1917 468,803 13 27.7 3 6.4 17 36.3 1918 476,216 7 14.7 5 10.5 19 39.9 1919 483,629 1 2.1 1 2.1 20 41.4 Data from the Reports of the Department of Public Health, San Francisco, Calif. Table IV Leprosy in Massachusetts, Penikese (Island) Hospital^ Ri ates per 1,000,000 Population Year Ei iding Admitted Died Remaining Novem) DerSO Population No. Rate No. ' Rate No. Rate 1905 3,003,680 5 1.7 — — 5 1.7 1906 3,076,224 — — — — 5 1.6 1907 3,148,768 4 1.3 1 0.3 8 2.5 1908 3,221,312 1 0.3 — — 8 2.5 1909 3,293,856 3 0.9 — — 10 3.0 1910 3,366,416 1 0.3 — — 11 33 1911 3,431,792 2 0.6 — — 13 3.8 1912 3,497,168 4 1.1 1 0.3 15 4.3 1913 3,562,544 2 0.6 1 0.3 15 4.2 1914 3,627,920 — — 1 0.3 13 3.6 1915 3,693.310 1 0.3 3 0.8 11 3.0 1916 3,758,688 2 0.5 4 1.1 9 2.4 1917 3,824,067 3 0.8 1 0.3 11 2.9 1918 3,889,446 2 0.5 — — 12 3.1 1919 3,954,825 2 0.5 — — 13 3.3 D ata from the Reports of the State Board of Charities ; of Massachusetts. *0f the 29 lepers apprehended in the state of Massachusetts during the period 1882-1915, the distribu- tion by types of disease was as follows: Tubercular 22, or 75.9 per cent.; anesthetic 4, or 13.8 per cent.; mixed 2, or 6.9 per cent. ; unknown 1, or 3.4 per cent. Of the total number of admissions 23 were males and 6 were females ; of the latter, 4 were of the tubercular type. Of the 23 male cases apprehended, 9, or 39.1 per cent., died during the period under review; or, if the tubercular cases are separately considered, out of 18 cases, 7 died, or 38.9 per cent. Of the 6 female cases, 2 died, or 33.3 per cent. Of the 29 cases, 10, or 34.1 per cent., were of the age period 20-29, which may be considered the age period most liable to infection. Of the 29 cases only 4 were natives of the United States, and of these, two were born in the Hawaiian Islands, 1 in a foreign country and only 1 in the state of Louisiana. The remainder had come to this country from the Azores, Cape Verde, British West Indies, China, Greece, Italy, Japan, Russia, Sweden and Syria. 42 Table V Leprosy in the United States Registration Area Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 Population 30,794,273 31,370,952 32,029,815 32,701,083 33,349,139 34,094,605 41,983,419 43,016,990 46,789,913 50,870,518 53,843,896 59,275,977 60,427,133 63,299,164 65,989,295 67,336,992 71,621,632 75,527,486 81,868,104 Deaths 4 6 5 4 4 8 3 7 11 9 10 7 11 6 12 13 11 17 24 Rate per Million 0.13 0.19 0.16 0.12 0.12 0.23 0.07 0.16 0.24 0.18 0.19 0.12 0.18 0.09 0.18 0.19 0.15 0.23 0.29 Table VI Deaths from Leprosy in the United States Registration Area BY States, 1907-1918 , ^YEARS . States '07 '08 '09 '10 '11 '12 '13 '14 '\5 '16 '17 '18 Total CaUfornia 353243-33— 6^ 37 Connecticut — — — — — — 1 " ~ ~ f- Florida _2-l---211^19 Indiana — • — — — — 1 -,,^ Louisiana* 1 2— 2 — - — — 1 — — 11 17 Massachusetts 1 — — — — 1 1 1 3 4 1 — 12 Michigan — — — — — 2 2— 4 Minnesota __— 1 2— 1— 1 1 — — 7 New Jersey _ — — — — ~~ ~ ~ ~ ~Z ] ~^ ^n New York 1-211112-442 19 Ohio - ^ — ~~~~~~'~~''Z1. \ Pennsylvania — 1 — — — — — 1 ^ ^ Rhode Island __ — — — — — — 1 — — — 1 South Carolina — — — 2 — — — 2— 1 1 1 7 Texas i _ _ _ _ _ 2 1 1 - 2 - 7 Washington — — — — — — — — ^ j Wisconsin — — — 1 — — — Registration cities in other States — — 4 — — 3 — — ' 139 ♦For years previous to 1918, data for New Orleans only. 43 Year 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 Table VII lY FROM Leprosy in Cuba, 1903-1914 Deaths Rate per Population from Leprosy Million 1,751,366 17 9.7 1,810,889 31 17.1 1,870,412 17 9.1 1,929,935 29 15.0 1,989,458 39 19.6 2,048,980 47 22.9 2,082,691 30 14.4 2,116,402 25 11.8 2,150,112 35 16.3 2,183,823 53 24.3 2,217,534 37 16.7 2,251,245 43 19.1 2,284,956 45 19.7 Source: Sanidad y Beneficencia, Boletin Oficial de la Secretaria, Habana. Table VIII Leprosy in Cuba Year 1909 1910 1911 1912 1913 1914 Population 2,116,402 2,150,112 2,183,823 2,217,534 2,251,245 2,284,956 Reported Cases Remaining at End of Each Year 321 343 350 338 341 351 Rate per Million of Population 151.7 159.5 160.3 152.4 151.5 153.6 Data from Sanidad y Beneficencia, Boletin Oficial de la Secretaria, Habana. Table IX Statistics of the Leper Colony, Goat Island, San Juan, Porto Rico, 1905-1919 Year 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 Population of Porto Rico 1,042,342 1,058,134 1,073,926 1,089,718 1,105,510 1,121,302 1,137,094 1,152,886 1,168,678 1,184,470 1,200,262 1,216,054 1,231,846 1,247,638 1,263,430 Rate Per Inmates on Million of June 30 Population 18 17.3 25 23.6 25 23.3 19 17.4 24 21.7 25 22.3 25 22.0 28 24.3 28 24.0 36 30.4 39 32.5 39 31.3 39 30.9 Source : Annual Reports of the Governor of Porto Rico to the Secretary of War. 44 Table X Leprosy in Panama Canal Zone, Palo Seco Leper Asylum Rates per 1,000,000 Population of Panama Canal Zone and Cities of Colon and Panama Ada: lissions Deaths Remainine Year Population No. Rate No. Rate No. Rate 1907 102,133 — 1 9.8 14 137.1 1908 120,097 14 116.6 — — 22 183.2 1909 135,180 24 177.5 1 7.4 34 251.5 1910 151,591 15 99.0 3 19.8 36 237.5 1911 156,936 24 152.9 2 12.7 49 312.2 1912 146,510 12 81.9 7 47.8 48 327.6 1913 129,104 15 116.2 9 69.7 45 348.6 1914 123,592 14 113.3 6 48.5 50 404.6 1915 121,650 11 90.4 2 16.4 58 476.8 1916 116,918 21 179.6 9 77.0 66 564.5 1917 (x) 114,003 11 96.5 7 61.4 67 587.7 1918 (x) 109,737 21 191.4 8 72.9 76 692.6 (x) Excluding the military for last six months of 1917 and the whole of 1918. Data from Reports of the Health Department of the Panama Canal. Table XI Leprosy in Panama Canal Zone, Palo Seco Leper Asylum Number of Deaths of Lepers from 1907-1915 Type of Disease on Admission Tubercular Anesthetic Mixed Total Males Number 18 3 3 24 Females Number 6 2 1 9 Males and Females Number 34 5 4 33 Nativity on Admission Number Males Nativity White Black United States 2 — Spain 1 — Panama — 6 Colombia — 2 Costa Rica — 1 Jamaica — 5 Barbados — 4 Antigua — 1 China — 1 Peru — 1 Number Females White Black Total 3 21 — 9 Source : From data received from Palo Seco Leper Asylum. Number Males and Females White Black 13 3 1 6 4 1 1 1 30 Note: — The average duration of the disease has been 7.5 years; or, roughly, 6.8 years for tubercular cases, 8.8 years for anesthetic cases, and 9.8 years for mixed cases. For ages under 15 the average dura- tion was 6.3 years, for ages 15 to 44 it was 6.8 years, and for ages 45 and over, 9.7 years. 45 Table XII Mortality from Leprosy in the City of Rio de Janeiro, 1890-1918 Year 1890 1891 1892 1893 1894 1895 1896 1897 1898 1899 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 Population 429,848 440,118 450,636 461,411 472,454 483,773 495,380 507,286 519,503 532,042 544,917 558,140 571,728 585,695 600,067 614,831 625,756 636,018 637,089 649,362 669,781 708,669 749,376 754,839 738,950 737,888 719,316 696,284 700,443 Deaths 9 13 14 20 18 18 19 18 13 22 10 16 19 20 23 25 22 34 20 14 11 29 25 16 27 21 19 21 23 Rate per Million 20.9 29.5 31.1 43.3 38.1 37.2 38.4 35.5 25.0 41.4 18.4 28.7 33.2 34.1 38.3 40.7 35.2 53.5 31.4 21.6 16.4 40.9 33.4 21.2 36.5 28.5 26.4 30.2 32.8 Source: Annuario de Estatistica Demographo-Sanitaria de Rio de Janeiro, and Boletim Mensal de Estatistica Demographo-Sanitaria. Table XIII Mortality from Leprosy, City of Sao Paulo, Brazil, 1901-1917 Year 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 Population 286,000 293,200 300,400 307,600 314,800 322,000 329,200 336,400 343,600 350,800 358,000 400,000 480,000 485,000 500,000 484,901 452,028 No. Deaths 5 10 4 6 7 17 11 11 6 23 21 24 19 21 23 32 26 Rate per Million 17.5 34.1 13.3 19.5 22.2 52.8 33.4 32.7 17.5 65.6 58.7 60.0 39.6 43.3 46.0 66.0 57.5 Data from Annuario Demographico, Seccao de Estatistica Demographo-Sanitaria de Sao Paulo. Annuario de Estatistica Demographo-Sanitaria de Rio de Janeiro. Boletim Hebdomadario de Estatistica Demographo-Sanitaria de Sao Paulo. 46 Table XIV Deaths from Leprosy in the Federal District of Rio de Janeiro, Brazil By Sex and Age 1909-1918 ]\L\LES Ages at Rate per Death Population Deaths MiUion Under 19 2,115,954 6 2.8 20-29 1,247,036 23 18.4 30-39 885,174 27 30.5 40-49 591,560 38 64.2 50-59 293,614 30 102.2 60-69 120,805 19 157.3 70 and Over 47,131 5 106.1 FEMALES Rate per Population Deaths Million 1,822,555 5 2.7 790,822 9 11.4 569,392 15 26.3 389,735 13 33.4 226,700 14 61.8 118,012 10 84.7 64,077 9 140.5 All Ages 5,301,274 148 27.9 3,981,293 75 Data from Annuario de Estatistica Demographo-Sanitaria de Rio de Janeiro. Table XV Mortality from Leprosy in the Federal District of Rio DE Janeiro, Brazil By Sex and Nativity 1909-1918 18.8 MALES females Rate per Nativity Population Deaths Million Brazilian 3,575,179 97 27.1 Portugese 1,164,160 33 28.4 Italian 196,147 7 35.7 Spanish 161,159 5 31.0 Other European 66,266 4 60.4 Turko-Arabic 21,735 2 92.0 AU Other 116,628 — Population 3,298,899 361,900 96,347 75,246 54,146 10,749 84,006 Deaths 64 6 1 1 1 . 1 1 Rate per MiUion 19.4 16.6 10.4 13.3 18.5 93.0 11.9 All Nativities 5,301,274 148 27.9 3,981,293 75 18.8 Data from Annuario de Estatistica Demographo-Sanitaria de Rio de Janerio. Table XVI Mortality from Leprosy, City of Recife (Pernajmbuco), Brazil 1907-1920 Year 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 Population 159,480 166,110 172,740 179,370 186,000 210,000 230,000 232,500 235,000 237,500 240,000 No. of Deaths 18 19 12 12 3. 10 10 6 8 8 9 Rate per Million 112.9 114.4 69.5 66.9 16.1 47.6 43.5 25.8 34.0 33.7 37.5 Data from Annuario de Estatistica Demographo-Sanitaria de Rio de Janeiro. Boletim Mensal de Estatistica Demographo-Sanitaria do Municipio do Recife. 47 Table XVII Deaths FROM Leprosy AND Number of Inmates IN Leper Asylums, Venezueia, 1905-1918 Inmates in Deaths from Rate per Leper Asylums Rate per Year Population Leprosy Million December 31 Million 1905 2,609,108 81 31.0 1906 2,627,069 74 28.2 1907 2,649,995 51 19.2 666 251.3 1908 2,664,233 37 13.9 632 237.2 1909 2,685,432 48 17.9 621 231.2 1910 2,713,523 22 8.1 612 225.5 1911 2,743,833 24 8.7 611 222.7 1912 2,755,630 62 22.5 582 211.2 1913 ^ 2,780,281 57 20.5 523 188.1 1914 2,805,269 25 8.9 499 177.9 1915 2,818,173 45 16.0 676 239.9 1916 2,827,762 71 25.1 650 229.9 1917 2,848,121 33 11.6 626 219.8 1918 2,868,480 28 9.8 753 262.5 Data from Anuario Estadistico de Venezuela and Memoria del Ministerio de Fomento. Table XVIII Mortality of Lepers in the Lazaretto of Barbados For the Period, 1890-1917 Males and Females Causes of Death Dysentery Leprosy Tuberculous Lungs Other General Apoplexy Paralysis Other Nervous Organic Heart Disease Other Circulatory Respiratory Diarrhea and Enteritis Other Digestive Brights Disease Other Urinary Gangrene Ill-defined Tubercular Males Females No. No. 2 125 17 4 1 2 4 4 7 1 1 3 2 1 79 12 3 1 1 6 1 1 2 3 Anesthetic Males Females No. No. 2 — 21 7 5 6 3 1 All Causes 173 118 68 Data from The Barbados Blue Book. 29 10 2 3 2 1 2 2 54 Mixed Males Females No. No. — 2 All Types Males Females No. No. 4 149 24 10 6 4 3 12 1 6 10 3 2 2 4 6 1 112 22 5 3 3 2 10 3 1 3 3 1 4 7 246 180 48 Table XIX Leprosy in India, 1911 Number of Lepers by Aj ge and Sex ALL INDIA NATIVE STATED 5 Ages Males Females Total Males Females Total Under 5 245 188 433 59 51 110 5-9 568 419 987 99 99 198 10-14 1,692 1,144 2,836 306 223 529 15-19 3,185 1,814 4,999 490 311 801 20-24 4,752 2,344 7,096 738 425 1,163 25-29 7,174 2,653 9,827 1,035 449 1,484 30-34 9,517 3,327 12,844 1,342 511 1,953 35-39 9,761 2,754 12,515 1,282 422 1,704 40-44 12,542 3,558 16,100 1,929 702 2,631 45-49 8,503 2,252 10,755 1,082 316 1,398 50-54 9,617 3,025 12,642 1,515 545 2,060 55-59 3,974 1,260 5,234 537 152 689 60-64 5,553 1,951 7,504 823 324 1,147 65-69 1,437 472 1,909 192 61 253 70 and over 2,438 892 3,330 356 125 481 Unknown 66 17 83 109,094 49 11 4,827 60 Total 81,024 28,070 11,834 16,661 Rate per 100,000 of population 50.2 18.2 34.6 32.5 14.0 23.5 Data from Census of India, 1911, Volume I. Table XX Statistics of the Leper Settlement at Molokai, Hawaii Admissions, Inmates and Deaths of Lepers, 1866-1919 Rate per 100,000 Population of Hawaii Admissions to Calendar Molokai Year Number Rate 1866 (a) 141 223.9 1867 91 146.9 1868 131 215.0 1869 190 317.0 1870 57 96.7 1871 178 307.4 1872 91 159.9 1873 415 727.1 1874 78 136.2 1875 178 309.9 1876 75 130.2 1877 122 211.1 1878 209 360.4 1879 92 149.0 1880 51 77.8 1881 195 281.5 1882 70 95.8 1883 300 390.6 1884 108 134.0 1885 103 125.4 1886 43 51.4 1887 220 258.0 (a) Settlement established Janua Number of Lepers in Molokai December 31 Number Rate 115 182.7 170 274.4 267 438.1 392 654.1 392 665.3 518 894.5 546 959.6 810 1,419.1 731 1,276.7 754 1,312.7 704 1,221.8 694 1,200.6 792 1,365.9 688 1,114.2 589 899.0 654 944.0 613 839.2 763 993.3 702 871.2 663 807.1 600 716.7 708 830.2 Deaths from all Causes Number Rate 36 57.2 24 38.7 27 44.3 59 98.4 57 96.7 52 89.8 63 110.7 142 248.8 141 246.2 149 259.4 119 206.5 129 223.2 111 191.4 194 314.2 151 230.5 129 186.2 111 152.0 150 195.3 167 207.3 142 172.9 101 120.6 111 130.2 Table XX (Continued) Numl ber of Lepers Admissions to in Molokai Deaths from Calendar Molokai December 31 all Causes Year N'mnber Rate Nmnber Rate Number Rate 1888 571 657.4 1,033 1,189.4 236 271.7 1889 307 347.1 1,187 1,342.4 149 168.5 1890 185 205.6 1,213 1,347.9 158 175.6 1891 141 151.4 1,142 1,225.8 210 225.4 1892 105 109.0 1,095 1,136.7 152 157.8 1893 209 210.0 1,153 1,158.7 151 151.8 1894 129 125.6 1,123 1,093.7 159 154.9 1895 105 99.2 1,087 1,027.0 141 133.2 1896 142 130.3 1,115 1,022.7 114 104.6 1897 , 124 103.1 1,099 913.8 140 116.4 1898 75 57.0 1,059 805.3 114 86.7 1899 61 42.7 1,014 710.3 104 72.9 1900 109 70.8 983 638.3 134 87.0 1901 94 59.6 900 570.4 172 109.0 1902 80 49.5 874 540.9 106 65.6 1903 114 68.9 872 527.3 101 61.1 1904 92 54.4 856 506.0 107 63.3 1905 95 54.9 854 493.8 95 54.9 1906 64 36.2 834 471.9 84 47.5 1907 78 43.2 809 448.1 88 48.7 1908 32 17.4 771 418.3 59 32.0 1909 (b) 11 11.4 723 376.0 34 35.4 1910 (c) 47 24.6 614 321.3 90 47.1 1911 40 19.9 592 295.2 61 30.4 1912 91 43.5 622 297.4 64 30.6 1913 113 51.9 683 313.7 49 22.5 1914 67 29.5 666 292.9 75 33.0 1915 49 21.2 638 275.9 62 26.8 1916 57 24.0 . 629 264.7 66 27.8 1917 34 13.6 587 234.2 62 24.7 1918 89 34.7 608 237.3 67 26.2 1919 61 23.1 611 231.7 57 21.6 (b) Six months ending June 30. (c) Years ending June 30, after 1910. Source: For 1866-1908, Report of the Board of Health of Hawaii, 1909, p. 186; for subsequent years, see Annual Reports of the Territorial Board of Health. Table XXI Leprosy IN Hawaii Type oi ■ Leprosy Molokai, 1901-1913 Tx-ix- Tubercular Anesthetic Mixed Not Given Number of Cases 384 327 275 74 Per Cent. 36.2 30.9 25.9 7.0 Total 1.060 100.0 50 Table XXII Leprosy in Hawaii Lepers by Race and Sex MoLOKAi, June 30, 1918 Rate per 100,000 Population Males Race Number Rate Hawaiian 210 1,780.7 Part Hawaiian 64 795.3 Korean 12 276.8 Portuguese 33 262.3 Spanish 2 162.6 Chinese 25 142.0 Filipino 12 65.4 Porto Rican 2 65.1 Other Caucasian 5 26.4 Japanese 12 16.3 Females Number Rate 157 1,419.9 57 707.8 Total 377 222.0 14 2 1 231 120.0 267.6 Table XXIII Leprosy in the Union of South Africa Number of Lepers in Institutions, by Color, 1910 to 1918 Rates per 1,000,000 of Population WHITE — COLORED - Year Population Number Rate Population Number Rate 1910 1,255,545 144 114.69 4,621,531 1,678 363.08 1911 1,280,381 155 121.06 4,722,720 1,782 377.32 1912 1,305,217 184 140.97 4,827,114 2,042 423.03 1913 1,330,053 190 142.85 4,935,027 2,054 416.21 1914 1,354,889 186 137.28 5,046,585 2,006 397.50 1915 1,379,725 187 135.53 5,161,950 2,080 402.95 1916 1,404,561 193 137.41 5,281,266 2,088 395.36 1917 1,429,397 186 130.12 5,404,707 2,146 397.06 1918 1,454,232 175 120.34 5,532,455 2,055 371.44 Data from Quarterly Abstract of Union Statistics, Number One, January, 1920. (Office of Census and Statistics, Victoria.) 51 Table XXIV Leprosy— -United Stat States Alabama Arizona 1 s a Arkansas California 39 23 Colorado 3 3 Connecticut 5 1 Delaware Florida Georgia Idaho Illinois Indiana Iowa Kansas Kentucky 2 2 Louisiana 87 — 87 Maine Maryland Massachusetts Michigan Minnesota 13 1 10 2 2 1 Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico 1 2 Information not 1 3 1 available 1 3 1 New York 28t 7 North Carolina North Dakota 1 Ohio Oklahoma 1920^ Official (State) provisions for lepers Isolation. Strict quarantine — deportation to Island for Lepers. (?) Not stated. Leper colonies at San Francisco, Los Angeles, local isolation. Quarantine by county, pending removal to Government Lepro- sarium ! State aid — put in isolation hos- pital. Quarantined as other communi- cable diseases. No provisions for lepers. Not stated. Isolated at county expense. No provisions for lepers. Not stated. No provisions for lepers. State Board of Health would pro- vide in emergency. Under State control, isolation, (Louisiana Leper Home.) Not stated. Leper must be cared for where found. Leper Colony at Penikese Island. No provisions for lepers. Under control of local Board of Health, isolated in own house- hold. Not stated. Case isolated at county expense. No provisions for lepers. No provisions for lepers. No provisions for lepers. No provisions for lepers. None other than modified isola- tion at home. Every case investigated and diag- nosis made. Isolation. (?) Not stated. Controlled by local Board of Health. Isolated in home especially pre- pared on grounds of Dayton Quarantine Hospital. Not stated. ♦Results of special inquiry in co-operation with State and local Departments of Health. tNew York City only. 52 Table XXIV (Continued) States Number of known leperi in State January 1, 1920 "S I doubtful, additional oi suspected cases a 3 cases officially segregated during 1919 Official (State) provisions for lepers Oregon 1 1 Isolation. Pennsylvania 6 — Rhode Island No provisions for lepers. South Carolina 2 Not stated. South Dakota No provisions for lepers. Tennessee No provisions made. Texas 33 — Not stated. Utah None except notification and casual quarantine or segrega- tion. Vermont Not stated. Virginia 1 1 Cared for by local authorities. Washington 1 1 Isolated. West Virginia No provisions for lepers. Wisconsin 2 1 Isolated — and attendant provided. Wyoming Placed in pesthouse same as any other contagious disease. Dist. of Columbia Isolation remote from persons not having disease. Total 242 7 134 Porto Rico 37 — — There is a law for isolation and segregation.* *See footnote page 17. 53 COLUMBIA UNIVERSITY LIBRARIES DATE DUE FEB- 1 fJ ?frri*) L, sl^l# ^ r i'uiyj miTi im ^^^" ^ , ^ UtMCO 38-296 THE PRUDENTIAL INSURANCE COMPANY OF AMERICA IscorporaUd under the Uws of the State of New Jersey FOBBEST F. DBYDEN, Pretideia HOME OFFICE, NEWARK, NEW JERSEY 98183