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This institution reserves the right to refuse to accept a copy order if, in its judgement, fulfillment of the order would involve violation of the copyright law. AUTHOR: SNOW, HERBERT LUMLEY TITLE: ON THE UTTER FUTLITY OF VIVISECTION AS... PLACE: LONDON DA TE : 1908 COLUMBIA UNIVERSITY LIBRARIES PRESERVATION DEPARTMENT BIBLIOGRAPHIC MICROFORM TARGET Master Negative # Original Material as Filmed - Existing Bibliographic Record ■•MMarMbMp • 179.d- I :z4 v,4 'rr^ymr^mrm^^m^'^^^^f^lf^ ^f^mmar^Mmtm nt^tmm^* Snov/ , Horbort.L 1847-1930. On the utter futility of vivisection as a means of promotin{3 medical science, with suggested lines for future renearch v/ithout employing experimonta- * tion on (sentient) anim£ils, by Herbert Snow... I London, International medical anti-vivisection as- sociation (British section), 1908. cover title, 40 p* Sl^- cm in 24 cm, ' Volume of pamphlets Restrictions on Use: TECHNICAL MICROFORM DATA FILM SIZE: 3J^j^^__^_ IMAGE PLACEMENT: lA (TIS IB IIB REDUCTION RATIO:„^<3/ r^' DATE FILMED: Jji^_^riJ_ INITIALS d^^ HLMEDBY: RESEARCH PUBLICATIONS. INC WOODBRIDGE. CT Association for Informsition and image IManagement 1100 Wayne Avenue, Suite 1100 Silver Sprirg. Maryland 20910 301/587-8202 11 ,1 Centimeter 1 23456789 10 |iiiiIimiIiiiiIiiiiIiiiiIii|iIii|iIm[iL 1 2 3 4 Inches 12 13 14 15 mm 1.0 IM 2.8 msa y^ ||J1 16.3 !^ m 1.4 2.5 I.I 2.0 1.8 1.6 1.25 TTT lllllllllllllllllllll TTT +1 V. \ MflNUFnCTURED TO flllM STFINDnRDS BY PPPLIED IMPGE, INC. J. lu '- f i On the Utter Futility of Vivisection « as a means of promoting Medical Science, WITH Suggested lines for Future Research without Employing Experimentation on (Sentient) Animals. BY HERBERT SNOW, M.D. (Lond.), etc. Consulting Surgeon, National Anti-Vivisection Haspital, Chairman, British Section of the International Medical Anti- Vivisection Association, Late Senior Surgeon (29 years Surgeon), Cancer Hospital. '^<^ PUBLISHED BY THE International Medical Anti- Vivisection Association (BRITISH SECTION), 224, Lauderdale Mansions, Maida Vale, London, W. 1908. Price 2d. International Medical Anti-Vivisection Association. rJI 1! ©bjectSt i._To unite the numerous medical men and women in different countries, who disapprove of experiments on living animals, into one organisation, which, by united work and the influence of its opinions, can become a powerful agent for the suppression of such experiments. 2.— To protest against the claims of advocates of vivisection, that the practice is indispensable for the advancement of physiological science and of medicine. 3. — To spread knowledge of the intellectual errors in vivisection as a method of physiological enquiry and of the uselessness of animal experimentation for the purpose of serving the art of healing, and of prolonging and saving human life, and also to expose the contradictions, mistakes, and failures in the various branches of vivisectional research and results, and to bring the names and work of notable scientific opponents of vivisection before the public, and to effect this by being instrumental in the production and distribution of literature on these subjects, and the organisation of lectures. 4. — To encourage biological research not connected with vivisection, and all scientific pursuits which are free from the taint of animal ex- perimentation of a painful and violating kind and likely to lead to new discoveries, helpful in the alleviation of suffering and extermination of disease, or conducive to a higher and more sympathetic understanding of the laws that govern the manifestations of life. 5. — To endeavour to raise funds, which would enable the Association in the future to offer prizes and institute scholarships for research work, manifestly independent of such animal experimentation and in accordance with true «cientific progress and the aims of the Association, thereby offering to students of physiology and of medicine special facility for taking up scientific investigation far in advance of the crude methods of the vivisectional laboratory. 6.-^ The Association shall first and foremost work within its own sphere of activity as indicated above, and, whilst inviting the co-opera- tion of other anti-vivisection societies, will not, from the nature of its organisation, interfere with the work or tactics of such societies, and it will seek at all times to advocate its ideas in an openminded, fair, and temperate manner. f I. Introductohy. And for this goddess, .Science, hard and stern, We shall not let her priests torment and burn ; We fought the priests before, and not in vain, And as we fought before, so shall we fight again. Le2vis Morris, More than thirty years ago that most renowned High Priest of Vivisection, Claude Bernard, made the fol- lowing significant statement : — '' Sans doute nos mains sont vides aujourd'hui ; mais notre bouche peut etre pleine de legitimes promesses pour I'avenir." Le^ms sur le Diabete, p. 43, Paris, 1877. So after all the lapse of time — after all the suffering that has since ensued, after the vast hecatombs of slaughter which the intervening years have witnessed, and which annually wax larger^ — do matters stand exactly to-day. Promises still abound. Of fulfilment there is none. True it is that on every side we find pretences, blatant enough, of success ; and such a thing as failure is rarely admitted, — never, unless the confession becomes inevi- table. Even then, however, plausible explanation or excuse is rarely wanting. And usually it is of such a sort as materially to confuse the uninitiated, and to augment popular faith in Vivisection, as the font of all present or future medical good. * It is believed that over 100,000 dogs are now sacrificed every year in Germany alone, to say nothing of other animals or other countries. In 1871 there were only 478 Vivisection experiments in England and Wales; in 1905 there were 37,935 ; in 1906, 46,073 ; in 1907, 73,374, — an increase of 27,301 upon the previous year. Without anaesthetics, are returned 35,429 in 1905 ; 43,287 in 1906 : 70,794 in 1907. International Medical Anti-Vivisection Association. ©bjectSt I. — To unite the numerous medical men and women in different countries, who disapprove of experiments on living animals, into one organisation, which, by united work and the influence of its opinions, can become a powerful agent for the suppression of such experiments. 2. —To protest against the claims of advocates of vivisection, that the practice is indispensable for the advancement of physiological science and of medicine. 3. — To spread knowledge of the intellectual errors in vivisection as a method of physiological enquiry and of the uselessness of animal experimentation for the purpose of serving the art of healing, and of prolonging and saving human life, and also to expose the contradictions, mistakes, and failures in the various branches of vivisectional research and results, and to bring the names and work of notable scientific opponents of vivisection before the public, and to effect this by being instrumental in the production and distribution of literature on these subjects, and the organisation of lectures. 4. — To encourage biological research not connected with vivisection, and all scientific pursuits which are free from the taint of animal ex- perimentation of a painful and violating kind and likely to lead to new discoveries, helpful in the alleviation of suffering and extermination of disease, or conducive to a higher and more sympathetic understanding of the laws that govern the manifestations of life. 5. — To endeavour to raise funds, which would enable the Association in the future to offer prizes and institute scholarships for research work, manifestly independent of such animal experimentation and in accordance with true «cientific progress and the aims of the Association, thereby offering to students of physiology and of medicine special facility for taking up scientific investigation far in advance of the crude methods of the vivisectional laboratory. 6. — The Association shall first and foremost work within its own sphere of activity as indicated above, and, whilst inviting the co-opera- tion of other anti-vivisection societies, will not, from the nature of its organisation, interfere with the work or tactics of such societies, and it will seek at all times to advocate its ideas in an openminded, fair, and temperate manner. L Introductory. And for this goddess, Science, hard and stern, We shall not let her priests torment and burn ; We fought the priests before, and not in vain, And as we fought before, so shall we fight again. Lewis Mmris, More than thirty years ago that most renowned High Priest of Vivisection, Claude Bernard, made the fol- lowing significant statement : — '* Sans doute nos mains sont vides aujourd'hui ; mais notre bouche peut etre pleine de legitimes promesses pour Tavenir." Legons sur U Diahete, p. 43, Paris, 1877. So after all the lapse of time — after all the suffering that has since ensued, after the vast hecatombs of slaughter which the intervening years have witnessed, and which annually wax larger^ — do matters stand exactly to-day. Promises still abound. Of fulfilment there is none. True it is that on every side we find pretences, blatant enough, of success ; and such a thing as failure is rarely admitted, — never, unless the confession becomes inevi- table. Even then, however, plausible explanation or excuse is rarely wanting. And usually it is of such a sort as materially to confuse the uninitiated, and to augment popular faith in Vivisection, as the font of all present or future medical good. * It is believed that over 100,000 dogs are now sacrificed every year in Germany alone, to say nothing of other animals or other countries. In 1871 there were only 478 Vivisection experiments in England and Wales; in 1905 there were 37,935 ; in 1906, 46,073 ; in 1907, 73,374, — an increase of 27,301 upon the previous year. Without anaesthetics, are returned 35,429 in 1905 ; 43,287 in 1906 : 70,794 in 1907. t Again even the minute modicum of success — and fractional indeed that is when we have occasion to estimate the blood and pain it has caused — invariably proves on judicial examination to have been no more than illusory. On looking below the surface, we are usually unable to find as the outcome of some loudly vaunted "medical improvement'' or "physiological discovery," a single fact of abstract scientific validity — much less of practical utility towards the Art of Healing. Everything vanishes into thin air at the magic touch of a rational and prudent scepticism. Witness the experiences of the Toronto doctors with the much vaunted Diphtheria-Antitoxin (Appendix to Third Report of Evidence before the Royal Com- mission on Vivisection, p. 232j ; or Dr. KJein's criti- cisms on Pasteur's " discovery " at the time. But withal there is no lack of promises. So many mice are now sacrificed by the hundred thousand — the Imperial Cancer Eesearch Fund alone admits having disposed of more than that number, and numerous foreign or other laboratories are working hard on similar lines — that the long sought desideratum, a non-operative cure for cancer must inevitably be discovered ere long. Such the expenditure of scientific ardour, of energy, of talent, of money zealously lavished by millionaires — that no reasonable person (outside the ranks of anti- vivisection heretics) can entertain a doubt on the point. Still less is it open to question that the foul fiend TUBERCULOSIS, — the decimator of our crowded cities, the ever-present " Dweller on the Threshold " of Civilization — will also speedily be slain. Note always the future tense. Some twenty years ago an "infallible" cure was proclaimed by a famous vivisector, and the medical world eagerly rushed to Berlin to learn the method at the Master's feet. But this remedy " heralded as a miracle " proved far worse than the disease, and achieved no more lasting result than the complete stultification of the Faculty. Untaught by the bitter lesson, "medical science "even now dwells regretfully on Tuberculin in various guises, rings changes on the theme in the shape of sundry " modifications," is reluctant to discard it altogether. "^ More recently a Koyal Commission, replete with the highest Vivisection ability the medical schools can shew, has attacked the subject. It has untold wealth at its command, uses two separate farms, to say nothing of laboratories, for its living-animal experiments. It has occupied five years in a Eesearch which is only "preliminary"; and the extent of its labours may be inferred from the fact that the list of live creatures dealt with comprises cattle, goats, pigs, guinea-pigs, dogs, rabbits, and monkeys with the chimpanzee. An interim Report shews that the nett results of all this waste of valuable force are practically nil. No discovery is announced. Not a single controversial point can be regarded as settled. Even the apparent disproof of Professor Koch's assertion that Bovine Tuberculosis is distinct from Human, and is incommunicable to man, only holds good till that eminent savant has had time to formulate a reply. We are no better able to grapple with Consumption than we were before. Nay rather the signs indicate that we are being sent on a wrong tack altogether. This giant pair of diseases, Cancer and Consumption, are the twin scourges of modern civilization ; and we see what Vivisection has so far done towards slaying them. * The two most phenomenal fiasooes witnessed by the present medical generation have been the furore about Koch's Tuberculin in 1891, and the conclusions of the Hyderabad Chloroform Commission in 1889. Both sprang from Vivisection. Sir Lauder Brunton's telegram announcing the latter may aptly be reproduced (Lancet, Dec. 5th, 1889): "490 dogs, horses, monkeys, goats, cats, and rabbits used. 120 with manometer. All records photographed. Numerous observations on every individual animal. Results most instructive. Danger from chloroform is asphyxia or overdose ; none whatever heart direct." or even abating their ravages. But many more, hardly- less formidable, abound ; and we are continually told that these are about to fall, under the thrust of the same doughty lance. Unfortunately they have not done so, as yet, although particularly strenuous eflforts are being made to prove that one at any rate — diph- theria — is actually laying down its arms. But it has not received the coup-de-grace ; and very strangely, has contrived to destroy a larger number of victims in the British Isles almost every single year since the introduction of the anti-toxin which was to have annihilated it, — than it ever did before. So also with the PLAGUE, which in spite of the invention of more than one serum-cure, contrived to kill in 1905, more than a million of our Indian fellow-subjects. The epidemics formerly, before the inoculations began, died out in 7 or 8 months. The last one, dating from the beginning of serum-therapy, has continued 11 years. So again with typhoid fever, tetanus, dysentery, and many more :~not forgetting hydrophobia, which luckily has not yet been endowed with an inoculation- factory here. So far as we have yet gone, the facts indubitably prove that the introduction and wide- spread use of an Anti-toxin or Serum to prevent or to cure any disease, is the sure index of^ an immediate increase in the statistics of mortality from that disease. But in spite of the unlimited depths of human credu- lity in medical matters, promises do not completely suffice to preserve implicit belief in Vivisection as a genuine aid to the Science and Art of Medicine. Con- sequently another prop has to be invoked— that for which I have previously ventured to coin the word *' Octopism.'' As every one knows, the Octopus, when unduly pressed by its foes, contrives to emit a dusky cloud — of ink ; under cover of which it can escape. So every portion of the very wide field now covered, or supposed to be covered, by living-animal Research, is densely enshrouded by a thick fog of fallacy and obscurity, through which no unaided eye can penetrate. It is always in the highest degree difiicult to discern what is actually being achieved in any particular depart- ment of Vivisection ; to judge whether anything valid or of practical utility is being done; to ascertain whether the huge husk of debatable matter really holds any solid kernel of fact — present or even potential. Overwhelmed by a continuous stream of unscrupulous assertion and vociferous self-laudation, the public mind cannot do this at all. It either surrenders its judgment altogether, or else, if compelled by natural instincts to doubt, it prefers to take refuge in non-technical argu- ments, based on Morality. Only expert scrutiny, combined with close and incessant study, can hope to grapple with the evergrowing cloud of falsehoods and fallacies, which the term '^Octopism'' is designed to cover ; to sift out the wheat (if indeed any such there be) from the chafi"; to analyse the pretensions of the Vivisection system. Sundry examples of this *' Octopism" will be detailed in the following pages. But the juggle between Pre- vention and Cure which is perpetually going on, in connection with Serum-therapy, afibrds the most salient example. That all-prevailing craze necessarily involves the maximum of doubtful and unverified premises; with the ne plus ultra of false and unwarranted ratio- cination from those premises. Pasteur counts as the Father of "Octopism"; and the Ai'ch-Perverter of modern Medicine — to which profession however, he fortunately did not belong. The history of the great Pasteur Bubble, which can only be noticed very cursorily in the pages following, is particularly instructive. Founded on error, and per- petuated by "bluflf," that science-gilded sham, the Institut Pasteur has long survived its founder, and thrives amazingly, to the present day. Likewise it has given birth to sundry similar vivisection-nurseries in other countries. Anti-toxins brought forward as prophylactic, speedily develope, as a rule, into curative remediee. They really do not prevent, neither do they cure. Only the skilful manner in which, under the false mask of " Science," they are commercially ** pushed" by wealthy and powerful interests admirably conceals this. The assump- tion of those virtues is always based upon statistics specially prone to fallacious interpretation ; besides being possibly liable to falsification by unscrupulous persons. In sanitary matters, almost all arithmetical data are very unsafe guides, and must never be taken to warrant more than the broadest generalisation. Those here in question are particularly unreliable. ^ When epidemic waves of any infectious disorder vary widely in virulence ; when individuals difier enormously in susceptibility to it, and when that disorder demands an uncertain period of time for its development after exposure to contagion, there can never be more than probability that a given remedy has acted as a prophy- lactic. The fact is not capable of proof by arithmetical data. It is prima facie obvious that such must always be jealously scrutinised before receiving credence at all. On the second attribute, the possession of curative properties, it must be noted that the manifold Sera in use are never pure. Every one contains a small quantity of Iodine, Carbolic Acid, or some similarly potent microbicide. At every hypodermic injection a minute dose of this chemical is introduced into the blood. It is well known that a very small quantity of almost any drug thus employed is equivalent in potency to a much larger, merely swallowed.* The percentage of cures with which even the most Even as I write, an Italian professor, Baccelli, exploits this tact as the basis of a novel mode of treatment. Vide New York Herald, Paris edition, Jan. 10th, 1908. successful of the Anti- toxins are credited by their advocates, falls far below the figure which might have been anticipated, were the claim really valid. Such as it is however — and disregarding for the moment all possible sources of fallacy — no practical man can reasonably doubt that whatever the efficacy of these nostrums, it should be attributed to the chemical agent they always contain ; and not to any supposititious " opsonic" influence, which has never been demon- strated ; or even rendered probable to any judicial enquirer. One of the principal elements of that "Octopism" which constitutes the foundation of the whole Vivisection system, is the introduction of spurious diagnostic rules, based on unscientific Bacteriology. Such for example is the Bacteriological test for Diphtheria ; substituted for the genuine clinical diagnosis previously current. It depends solely on the microscopic recognition of a microbe. That micro-organism has never been shewn to be the cause of the disease in question ; not even its invariable concomitant. The discoverers of the Diph- theria-bacillus could not find it in one case out of every four undoubted examples of the malady. The Tubercle- bacillus often cannot be detected in early cases of consumption ; or in lesions, such as Lupus, regarded by pathologists as Tubercular. Neither has its influence in causing consumption ever been proved. But such considerations have no weight when Vivisection is in question. We may leave them out of sight altogether. So with every other branch of the Healing Art, or department of medical activity associated therewith. On examination, their pretensions to have been aided or improved by experiment on the living animal are seen to be absurdly hollow and baseless. They too rest on " Octopism," and on that alone. ** Octopism" is the negation of true Science, and con- stitutes its opposite and antithesis in every essential particular. Science implies truth, accuracy, precision ; "Octopism" stands for the admission of every possible source of doubt confusion and error-so for conscious or unconscious falsehood. According to eminent author- ities bcien^e IS "simply common sense at its best" (Muxley, The Crapish); is "organised common sense" (bir Henry Eoscoe). It connotes therefore culture of the judicial faculties in the highest degree. " Octopism " i!!.TTi"'°'i-^' ^^^"^V^^^ to be given, implies abneg;. k l^,fi -fi '??17 reasoning powers. At its best, it IS but glonfed foUy_it may even be glorified fraud. rJTl^ endeavour to pierce to the core of things, regard Vivisection as not only an outrage on Moralit^ ^\l^f^ ^^'^^^'^'r^ t« the progress of Science properly RicW ^ *i .''' ^rf"""^*^^^^ impediment to the Higher Evolution of the race. Held forth for men's £w T r> '^'''*^''' "^ f ^ ^'^J"^'^* ^'^d aid to the Jlealmg Art, it is no more than a colossal sham. As suck mthout am questim of the cruelties it may involve, It should be totally abolished ^ Eestrictive legislation and government supervision o tP; A?/^ fT«t"t'^^ "^T^^' ^' '^' adminltratlon ot the Act of 1876 has conclusively shewn. Human nature being what it is, there can be no middle course! or half-way house. All legislative enactments on Vivisection, are disregarded or evaded. The revered Foundress of the Anti-Vivisection movement, the Tate a^d"inX;/r/ ^''^^'' ^"^ '^ '^' niost' practlS TnllP fe^^^ Of women, was compelled to adopt a effort .^?^^ *^'^ l"^^''^ K ^" ^P^*^ °^ l««g ^d strenuous nSw S' "^''1*^'° "^ compromise. ^She found that abusrSlt ,7«"H P^r'^t cruelty and intolerable h\Tcon!2n"^^ *''* '" ^"^^ ^^PP^'^^^ «^-g*l^-« 9 11. Previous Lights, mainly of a Surgical Order, ON THE Fallacies of Vivisection. It is always essential, in entering upon a scientific inquiry, first to consider carefully what previous in- vestigators have done. Without that preliminary step no new departure of value can take place. To the neglect of this principle must chiefly, if not entirely, be ascribed the present backwardness of Cancer Kesearch, and the remarkable absence of progress in that depart- ment. Every investigator seems to start de novo. And moreover it is a useful axiom to remember that a dwarf, perched on the shoulders of a giant, can always see a little further than the giant. In this connection we must begin by discussing the conclusions of a real ^' Giant of Intellect,"— for the late Professor Lawson Tait, from every point of view, was nothing less. He was not only the pioneer of modern Abdominal Surgery, and by far the most original and skilful operator of his day. His was also a remarkably versatile and broad Mind with wide interest in many other matters than those which concerned his profession. It may be re- garded without exaggeration, as one of the foremost in the illustrious Victorian era— a typical embodiment of " organised common sense/' The publication in 189.9 of Lawson Tait's pamphlet. The Uselessness of Vivisection as a Method of Scientific Research, constituted an epoch in the crusade against Vivisection which Miss Cobbe has the great glory of having initiated. With his incomparable mental grasp, he carefully analysed all the claims then put forth, on behalf of living-animal experiments as pro- moting the progress of Medicine and Surgery. In every instance he arrived at the conclusion that they were wholly invalid ; and that, so far from being an i 10 aid to medical science, the system really constitutes a grave obstruction and hindrance ; that it never adds, in the slightest degree, to our genuine knowledge. On the other hand that it diverts able and intelligent men from following those paths which might reasonably be expected to enlarge and increase the domain of Science. On his own special department, Lawson Tait's words are peculiarly significant and weighty. " I have had, as is well known, some share in this advance {i.e. that of Abdominal Surgery) : and I say, without hesitation that I have been led astray again and again by the published results of experi- ments on animals, and I have had to discard them entirely." On other surgical procedures he remarks : *' Injuries to arteries in the lower animals are repaired with the utmost certainty and readiness. But with man it is altogether dififerent. I once saw the leg of a favourite dog amputated at the hip-joint on account of disease and when the limb was removed, not a single vessel bled. Without sedulous precaution, a human being would perish of hoemorrhage under the same circumstances, within a few seconds." This observation alone suffices to shew the great gulf which obtains between man and the lower animals, for all Surgical scientific purpose. The two are wholly dis- similar. No single argument founded on the results of experiment among the latter can be reasonably applied to the former. The fact has since been corroborated in many other quarters, as before the Eoyal Commission. In that of INTESTINAL SURGERY, I personally re- member a Surgeon who had successfully effected artificial junction (anastomosis) between difierent portions of the intestine in various dogs, which be- trayed no ill-consequence. He then proceeded to perform a similar operation on patients in hospital, and these promptly died. Sir Frederick Treves has also recorded his experiences in the same direction. Coming as they do, from a man who cannot be sus- pected of the slightest sentimental leaning towards the i 11 Anti- Vivisection cause, they acquire exceptional signi- ficance and value. "Manj years ago, I carried out on the Continent sundry operations on the intestines of dogs, but such are the differences between the human and the canine bowel that when I came to operate on man, I found I was much hampered by my experience ; that I had every- thmg to unlearn ; and that my experiments had done little but unfit me to deal with the human intestines." — British Medical Journal, Nov. 5th, 1895. Besides the surgery of the abdomen, Lawson Tait also specially discussed the following topics : Amputation at the Hip joint, the Treatment of Head Injuries, Subcu- taneous Tenotomy, Tapping the Chest for Dropsical Eff*usion, Blood Transfusion, Hunters Treatment of Aneurism, the Functions of the Periosteum and the Detection of Poisons. Just previously strenuous claims had been put forth that Vivisection had efi'ected material progress— impossible of attainment in any other manner — in all those. In every single instance his verdict was —and he amply proved it by analysis— not only that the living-animal experiments which had been in- stituted were useless ; but often that they had been seriously misleading. In no case had they led to discovery or to beneficial innovation. Such a boasted example of Vivisection- benefits as John Hunter's Cure of Aneurism by liga- turing the artery at a distance, proved on investigation to have been obtained by observation in the hospital and the dead-house. The fact was admitted by no less celebrated a surgeon and no less pronounced an advocate of Vivisection than the late Sir James Paget. Since Lawson Tait's era, the two principal matters in which a similar claim has been made are myxoedema ; and the removal of tumours of the brain. Myxoedema is that remarkable cretinoid condition which afflicts people whose Thyroid Body has been ex- cised or has become disorganised by disease. Although Gull had previously noticed it, it was first fully recog- ••ii:re'<*'w?ffcsaa«4*jw. 12 nised and adequately described (in this country) by the late Dr. William Miller Ord, of St. Thomas' Hospital, as the result of research on the lines above mentioned. Not being a Vivisector, however, that able physician received no title or other reward for probably the most striking and original discovery of the generation.* Then subsequently— also without aid from Vivisection —Dr. W. Murray, of Newcastle, found that death is averted and distressing symptoms held in abeyance, by the continued administration of either sheep's Thyroids m bulk, or of the juice expressed therefrom. This treatment has held the field ever since. It cannot of course, be styled a " cure." The method has since assumed huge commercial importance, involving a most lucrative trade in Thyroid preparations. But it was no more than a common- sense deduction from readily-observed facts. It was not invented or discovered by means of any living- animal experiment whatsoever. It needed nothing of the kind for its support. The removal from the body of a certain glandular organ— or the morbid disorganisation of that organ- were seen to produce a peculiar train of symptoms. 1 hese must be due either to secretion or to excretion by the organ, could not possibly be ascribed to any other cause. As the Thyroid Body is not provided with a duct, the former almost certainly came first. That the Thyroid Body secretes anything at aJl was a fact previously unknown and unsuspected. Kocher independently des- cribed myxoedenia in Germany, about the same time ; but the fact does not lessen the credit due to Ord. Hardly any medical innovation now receives the smallest attention, unless associated with Vmsection-experiments. That may possibly be the reason why the only Cancer-discovery in my time-that a very prevalent kind ordinarily infects insidiously the marrow, and nZtTJ ?'. ^''"f ''*^. ^'^''' g'^'°^ "«« t° unwarrantable notions of constitutional ongin, ineradicability, Ac-has never fSsSC::.'"" ''^ ^^'^''' ^'^•'"^'^ of considerable l< ' 13 Common sense therefore naturally indicated treat- was at once found to answer remarkably well. Numerous Vivisection experiments also took place ; mainly in connection with the second or more butcherly plan, also deducible by ordinary reason, viz. replaceLnt of ItinT'S "^^^l ^y '"^^r ^ 3rafi from anotd hmng body. They proved admirably successful; JLa^ T* YT ^'"'"^ necessary to perpetuate this second mode of treatment. The living-lnimal experi- naents served the mam object of all medical Vivisection, they brought the first mode well into vogue. But otherwise they do not appear to have revealed any new tact, or to have elucidated any point which could not as readily have been ascertained without them Hitzig and Ferrier's researches on the Convolutions of the Bram and their Functions excited intense interest m physiological circles twenty-five years ago; and were at first thought to have inaugu/ated a new era m bram-surgery. It was subsequently ascertained however that the deductions were faulty ; and that many limitations and exceptions marred the practical rules which would otherwise have been established. Considerable disappointment soon arose. Other hieh authorities announced their scepticism. Charcot remarked ; — "The only really decisive data touching the cerebral patholojrv of Man are m my op.mon those developed ^.cording to thrprSles of Uie Anatomico-clmical method. That method consists in ?v!^ confronting the functional disorders, observed dt^Sf ^^th Z lesions discovered, and carefully located, after death. ^To it I mav Shis'-""' ""' '" ^"^'" ^°^^'^' ''^ ^^' "^ ^-^'^ Brown-S^quard pointed out the danger of reliance upon the results of living-animal expedient. FerriS himself describes the surprise of Morgagni at finding paralysis of the hmbs (Hemiplegia) on the same sSf 14 as the Brain-lesion ; whereas according to all recognised anatomical canons, it should have occurred on the opposite. He also admits (Functions of the Brain, Preface) that : " No one who has attentively studied the results of the labours of the numerous investigators in this field of research, can help being struck by the want of harmony and even positive contradictions among the conclusions which apparently the same experiments and the same facts have led to in different hands." Finally on the question of operative removal of brain-tumours, it is notorious that Surgery has almost absolutely failed ; that an operation is commonly fatal ; that even when the patient recovers, cures {i.e, dis- appearance of the distressing symptoms) are few and far between. Of 162 cases recorded by Starr in the New York Medical Record, Feb. 1st, 1896 ; in 35, the operation was fatal, and in 48 the tumour could not be found ; in 7, it was found but could not be excised ; in 72, the patient survived the removal — but that was all. Sir Victor Horsley, the most renowned Brain- operator in the world, has eulogised to the Royal Com- mission its successes; which he attributes to the previous localisation experiments. But he omits to adduce a solitary fact or figure in proof of that success, thus painfully neglecting to grasp a golden opportunity for convincing his own profession. Attempts — based in some measure on certain partic- ularly horrifying experiments at the Brown Institution upon living dogs— to ascribe modern improvements in the Surgery of the Kidney to Vivisection have also been made. But since the Surgeon whose name is most associated with progress in this department- Mr. Henry Morris, President of the Royal College of Surgeons— informed the Royal Commission that he had never vivisected and was in no way indebted for his skill to experiments upon living animals ; the claim can hardly be persisted in. The surgical removal 15 of the kidney moreover dates from the Greeks, and was known to Hippocrates as a feasible operation. HI. The Fundamental Difference in Organisation, BETWEEN Man and the Lower Animals. Between the structural and physiological organisation of Human and other living creatures, — even of those latter, such as the monkey, which are most closely akin, — there is an extremely pronounced difference. The details, in formation and function, are so numerous and so profound, that all scientific inference from one to the other, is wholly impossible. Even Professor Starling, who of all English Vivisectors is perhaps the most reckless in his advocacy of the system, has been constrained to inform the Sitting Royal Commission that living-animal experiments are of approximative value only. '' The final experiment m.ust always take place on Man!' This naive confession from such a source w^U-nigh suffices of itself to demolish the whole foundations of the Vivisection-system. Of what avail are all the horrible torments which the lower animals are con- fessedly made to undergo (^vide La Fisiologia del Dolore, by Mantegazza : Crile's notorious Experimental Research into Surgical Shock: et iis similia) if they point to nothing conclusive ? Or setting aside those agonies, which English vivisectors now deny, although proved to the Royal Commission of 1876 to have been then perpetrated here, what does it all amount to, but an absurd waste of force ? The gulf between our organisation and that of these creatures is most strikingly demonstrated by the different effect on them of poisonous drugs. Five grains of Opium or one grain of its principal alkaloid Morphia will kill a man. A rabbit can take 30 grains of Opium, 16 a pigeon 12 grains of Morphia with perfect impunity. In man, those drugs contract the pupil of the eye to a pin's point. In birds, the latter is not affected at all ; in horses it becomes widely dilated ; in dogs it first dilates, then contracts. We enjoy lemonade in the hot weather. Citric Acid, its basis, is a potent poison to cats and rabbits. Prussic Acid kills us and also elephants; but has no efi'ect on horses or hyaenas. Henbane, as the name indicates, is fatal to hens. It has no influence on sheep, cows, pigs. Eabbits eat belladonna, goats tobacco, sheep, horses, and goats browse on conium, the hemlock of Socrates. All are rank poisons to the human species. One often sees thrushes and blackbirds eagerly eating the berries of the Yew, or of the Cherry laurel with other fruits fatal to us. Table Salt is deadly to chickens. Many mammals love it, — the American bison used to travel over the prairies many hundreds of miles to the " Salt Licks." Men could hardly exist without it, certainly not in a condition of health. According to the Medical Press, **The common hedgehog can eat without discomfort as much opium as a Chinaman can smoke in a fortnight, and can wash the meal down with as much prussic acid as would kill a regiment of soldiers. It is capable of swallowing arsenic with as much relish as it eats cock- roaches. Finally it is immune to snake venom." Sir Lauder Brunton has pointed out that rabbits cannot vomit, because of the anatomical position of the stomach. Dogs, which lead such an active life and are capable of so much exertion and muscular endurance, —cannot therefore be suspected of having a weak heart — are yet remarkably prone to die from cardiac failure when exposed to chloroform-vapour. On the other hand they recover quickly from intestinal opera- tions and many injuries which would immediately kill a human being. An eel with its head cut ofi* will manifest every sign of sensibility ; so will a frog, whose cerebral hemispheres have been completely destroyed. * s 17 Excision of the Thyroid body is nearly always imme- diately fatal to dogs, cats, foxes ; rabbits, sheep, calves, and horses bear it well, and shew no ill symptom after- wards ; in man (as already stated) it produces Myxoe- dema, with death after a long interval. These are but a few of similar discrepancies which could be multiplied indefinitely. They serve however sufiiciently to shew how fallacious it is to reason from either natural or artificial biological phenomena in the lower animal creation to the same in Man. They indicate how far remote from the precise and logical deductions which true Science would demand inferences from such a source must almost necessarily be. And finally they serve to cast material doubt upon benefits to the Healing Art, likely to be derived from the novel " synthetic remedies," tons of which are sent every week to our shores by the German and other laboratories. These are invariably now foisted upon a somewhat credulous medical Faculty, on the faith of living animal experiments. Again the " Octopism" which cannot fail to attend this line of research, is readily shewn by the contra- dictions and absurdities into which successive investi- gators constantly plunge. Thus many years ago Anstie performed a series of very painful experiments upon cats and dogs, and concluded that Podophyllin does not increase the flow of bile. Rohrig did more, which wholly negatived that conclusion. Then Rutherford performed a 3rd series, vainly endeavouring to reconcile the verdicts of the two former. The matter is not yet decided. Drs. Ringer and Murrell experimented with Arsenic upon frogs (Journal of Physiology, I., p. 217). Dr. W. Stzlarck of Berlin (Reichert's ^rcAiv, 1866), obtained results diametrically opposite. The former gentleman then endeavoured to extricate physiological medicine from this difficulty by saying that the discrepancies in question depended upon the season of the year at which "'"'"llilB"- 18 the frogs were experimented upon ! ! ! (Berdoe, Futility of Experiments with Drugs on Animals, p. 13.) These are only samples of many similar happenings. Vimsection never finally settles anything. One in- vestigator's conclusions hold good only till they are overhauled by the next ; and his, until someone else takes a hand. The wheel continues to revolve, until eventually we arrive at those experiments on human bemgs, to which research on the living animal inevitably leads (iVeii; York Herald, January 1 0th, 1908, Paris Edition.) That is the great social danger of the Vivisection-System. Many instances of its occurrence even in England have proved it to be far from a light one. IV. Serum-Therapy— (a) Pasteurism. Hardly anything tends better to demonstrate the futihty of Vivisection-research as applied to the medical Art than the now fashionable Serum-therapy. This, not so much by reason of its many conspicuous failures,' as of the manner in which Failure is hidden ; and of the reckless assertions by which it is too frequently held forth to an ignorant and admiring world, as success. The corner-stone of the entire edifice of Serum- therapy is the Institut Pasteur, There is not the faintest reason to suppose that Pasteur's inoculations for Eabies have ever prevented the development of that dread disease in a single person who had actually contracted it. They are proved beyond any possibility of doubt to have conveyed Hydrophobia to sundry individuals who would not and could not have been attacked otherwise. Yet the great Pasteur Bubble has persisted, under distinguished professional auspices, from 1885 until now; and has emitted numerous offshoots. Well says the pithy proverb : '' Populus (TnedicusJ vult decipi et decipiatur." t'' 19 And so people raised a statue— towards which there were large subscriptions in England -to Pasteur. There can be no more striking testimony to the tremendous sway which scientific humbug, here denominated Uctopism, has acquired over the minds of men • for no so-called " Medical improvement'^ has from the'first been so utterly void of foundation in assured fact None has ever raised so dense an *'inky cloud'' of un- warranted assertion and of unfounded illusion. No vaunted ^* Scientific Discovery" could have more com- pletely disregarded those tests of accuracy and of veracity which Science always demands. No system of treatment could have set more effectually at naught the suggestions of ordinary prudence and common- sense. ^ Everything favoured the first blowing of the "bubble." Since the decease of the author, everything has com- bined to procure its expansion. At the time nothing was known as to the number of persons, among tho^ bitten by a mad dog, who subsequently developed rabies ; although it had always been notorious that many escaped wholly scatheless. Then there was a lengthy period of '' Incubation." After the bite, the malady did not shew itself for two months at least, possibly not for a year. Even longer intervals were claimed ; but all was hazy and obscure. Pasteur had already acquired world-wide renown as a Chemist. He had focussed men's attention on his dis- coveries in that department of Science. Pasteur's theory was that the spinal cords of artificially infected rabbits contain the virus of rabies " in its pure form,''— whatever that may mean.^ Also that they * The words are quoted from Professor C. J. Martin's evidence (Royal Commission on Vivisection, 11658). As no one has the faintest idea what the " virus " is,— it has not been isolated, and no microbic germ, in spite of the most persevering search has ever been detected in hydrophobia— the absurdity of the phrase is obvious. This point indicates the laxity with which words 20 contain an immunising '* vaccine" as well as this virus. That when dried, the virus gradually loses its potency ; but the vaccine only does so in much smaUer degree. So that ''the weaker cords (those dried for fourteen or thirteen days) possess not enough poison to give the disease, but enough vaccine to immunise the patient against stronger cords (those dried for a shorter time) which contained more 'vaccine' as well as more virus." (Stephen Smith.) This theory was never proved, although the treatment was begun immediately after its promulgation. It was founded on 50 dog-experiments, stated by Pasteur to have been uniformly successful.^ Professor Von Frisch, of Vienna, came to Paris to learn the method; then went home and repeated the experiments. All failed. For the treatment a dried cord (rabbit's) was mixed with veal broth into a liquid form. This was injected hypodermically . The first day, a cord dried for 1 4 days was used ; the next, one only 1 3 days old, and so on, in an ascending series, to a cord almost fresh. The time occupied was about a fortnight. On the publication of Von Frisch's report, M. Pasteur had to admit that his experiments had been only partially successful. Also he changed his method entirely. In- stead of the " Slow," occuppng 1 4 days ; it was necessary to inoculate every two hours, and using the w^hole series of cords in 24 hours or even less, — the "fiapid" treatment. Von Frisch went over the ground again, on the new system and " found it a complete failure.'* Still the inoculations were attracting people from every part of Europe; and at all hazards, must be are commonly employed in so-called " medical science,'* and made to depict wholly unknown things, in terms indicative of knowledge and reality. * " Sans avoir rencontr^ un seul insucc^/* i I 21 continued. From that time till his death, M. Pasteur s ingenuity was largely employed in devising plausible excuses for the numerous deaths which occurred in patients who had been subjected to his treatment ; and who, on grounds expressly stated by himself previously, should have been immune. Thus Lord Doneraile was inoculated on the 12th day after the bite (by a rabid fox) ; and died of rabies five months afterwards. M. Pasteur explained that an interval of 12 days was far too long. Secondly that in deference to the wishes of Lady Doneraile and of the previous medical attendant, he had, against his own better judgment, adopted the simple treatment only, instead of the modified which was then recommended. (British Medical Journal, Sept. 17th, 1887.) Lady Doneraile {Cork Constitution, Oct. 16th, 1887), flatly contradicts the latter statement. As to the former, two years later, M. Pasteur in the New Review, Dec. 1889, speaks of having encouraged a lady to come to him from Spain for treatment a year after the bite ; and says " It is never too late to begin the treatment." The paralytic form of rabies is very rare and ex- ceptional in human beings ; though it is the prevalent one in rabbits. Men suffer from the convulsive. In 1885, 7 out of 22 deaths among Pasteur's patients were from paralytic hydrophobia. A pricking sensation at the place of the bite is an ordinary symptom at the outset of rabies. In numerous fatal cases after the Pasteur treatment, this was felt, not there, but at the place of the inoculations. Lastly, in the cases of N^e of Arras, De Moens of Antwerp, Stobor of Lubline, and others : the treatment was instituted shortly after bite by a dog only suspected of being mad. The patient died of rabies, "The dog remained healthy and lived for years."* * A sad reversion of Goldsmith's tale : " The man recovered of the bite ; The dog it was that died." 22 by th/LocuIatirns tottl^^^^^^^^ "^^^.^ ««"-^yed wise have been attacked Tt dl '''"^'^ ""* «*^^^- stat^slE ^(Sjft^^^^^^^ Stephen Smith of all the Pasteurian era ^ the ^1,^ '^T *^'*^ ^° *^^^ P^^" Hydrophobia ;aron™ pef etf 5 t^'^".-^^- Now it is two Der fPnt T ^ j °^ *^°se bitten. has no PastrSitut ■ the J^f "* ^"S'^"^' ^^^^^ In many respects Pa"; -f.. ^-"^^ '' non-existent, whole glob'lSv s ?^ lt£^^^^^^ tl^e the corner-stone of the enttrvt- !^''''^^^' ^^'^«^e glamour of its fictitious triurDhlrr'r"'^?^^- ^h^ the minds of men ^"^^^P^s has effectuaUy dazzled kind of the futility of^Stln?r ' 'T^^^^ '"^°- which can be devLd. ' '^''^''^''''' *^^" any other measure (6) Diphtheria-Antitoxin of th': sr TIL' £W^™. r '^^ fi-*-bo- Pasteur Institut? in 18 JT.nf'^""/^ ^^ ^«»^' «f the in eonse,uencet/r " liS:^;^r^^^^^^ ^'^^^^'^^^ DipX^l^gSratSsT e'r • °^*^P^^ " ^^-'^«- varying virulence Tn?. ?u ^P''?^^"^ waves, of very treatment ifi S,Hn! ^'^ "'v^'^""' ^^^t^^^r the misleading. *''*'^' ^'^ peculiarly unreliable and forf Emlitdnt'^^l^^^^^^^^^^ --be, there- white peUicle which is sefnlfwf bacillus,»-in that patients. In The wonted non t' *^T "^ diphtheritic Vivisectionist, they IssumedT k"^!^'' ""^"°^^ «f the of the disease alti'Sw^^^^^^^^^ *°, ^^ *^^ -'^- it m 25 per cent, of ufdoS^^W i^ ^ '^*^^* 23 This causation has never been, even approximately, proved. The '' specific " baciJlus was found by Bitter in the mouths of 127 healthy children. It has since been noticed in very numerous conditions wholly unconnected with diphtheria, —e.^. in conjunctivitis, nasal catarrh, ozcena, fibrinous rhinitis, stomatitis, gangrene, noma, cancrum oris, tuberculous and em- physematous Imigs, vaccine pustules, &c.— a tolerablv wide field ! The impartial observer will therefore find it almost incredible that, in spite of all this, the medical world should have permitted itself to regard the Klebs-Loffler bacillus as the vera causa of diphtheria ; and so to have enthusiastically embraced the treatment founded on that view. But the Faculty have gone much further. It is still more incredible that, for the old common-sense method of diagnosis (based upon such obvious and unmistake- able signs as the white throat-peUicle, enlarged glands, constitutional symptoms, &c.) they should actually have consented to substitute as a test for Diphtheria, the presence of this microbe in the throat-secretions, as shewn, or thought to be shewn, by the microscope ! Irrational and unscientific treatment could not go far without adventitious or factitious support : neither has here been lacking. Of the former kind is the fact that the virulence of Diphtheria-epidemics has been shewn to proceed, through a long series of years, upwards to a maximum. After which, an equally gradual descent occurs. And in many places,— Paris, Vienna, Stockholm, Holland, German towns,— a special fall in the mortality was observed just before the introduction of the Anti- toxin. (Buning). Of the factitious order are (a) The wholesale inclusion of mild and doubtful cases, which necessarily results from the adoption of the baciliary test aforesaid, com- bined with the isolation zeal of up-to-date sanitary authorities. I have personally noticed most trivial cases yc f*- * ' •' 'V 24 which would otherwise have been well within a few hours swept compukorUy into the local isolation- hospital ; there presumably to swell, by their speedy recovery the triumphs of the Anti-toxin treatment. {b) Keliance upon the misleading statistics of the Metropolitan Asylums Board, which shew a decrease in mortality through the six serum years (from 1894)— but also an equally marked decrease through the six pre- cedmg The former are wholly vitiated by the Bacterio- logical test. '' (c) A third must be added— professional zeal. When- ever there exists strong medical bias in a certain direction It IS nearly always ea^y to support it by statistics which must not be too closely scrutinised. Yet in spite of aU these, and of the current fashion- wave which has overwhelmed medical judgment we have to face the alarming fact that the moHaliiy in England and Wales from Diphtheria has most alarm- tngly increased since the introduction of Anti-toxin in i onn 1*^" years previously, the deaths per milHon were 200 only For the ten subsequent, they were 235. in tne Uty ot London for the three years 1895-6-7 — the mortality was three times as high as in any of the 17 years 1865-1881. (Hadwen.) ^ Professor C J. Martin informs the sitting Eoyal Commission (Q. 12011) tha^t " paralytic symptorm are more common now than they were before the Serum treatment Also there are often distressing rashes; and other ill-eflfects. Drs. Nuttall and Smith in The Bac- terwhgy of Diphtheria (Cambridge, 1908) speak of Kxdney disease with dropsical sweUing as " quite reeu- larly observed." Also of local abscess, pain in the jainis fever and severe prostration Several fatal cases nave been recorded (p. 619). The Medical Officer of Health for Toronto (where a sceptical spirit on this question has always prevailed) m his report for 1904 says that in the last decade, the mortahty from Diphtheria was 16 per cent, under Anti- 25 toxin treatment, against only 12-2 under ordinary ditto. " In every year save one, the percentage of deaths in Anti-toxin cases, has been higher than the ordinary hospital rate." Before quittbg the topic of Diphtheria, it is important to note how the vogue of Serum-therapy has led the medical Faculty astray from other modes of treatment far more successful and reliable. 259 cases (in 5 series), treated by cyanide of mercury, formalin, corrosive sublimate, &c., without a single death, have been pub- lished. These are irritant poisons. But I can personally testify that full doses of a practically non-poisonous drug, sulphurous acid, never failed to efiace the charac- teristic white pellicle within 48 hours in any patient not absolutely moribund. And I never saw a case of paralysis after this treatment.* It is suggestive to find that the highest triumph of Serum-therapy (vide Prof Martin's Evidence, Eoyal Commission on Vivisection, Q. 11895), relates to a disease which can readily he subdued by other means wholly devoid of the drawbacks which attend Anti-toxin, — devoid indeed of any drawbacks whatever. It is no less interesting to discover the tendency academic professors have to substitute Serum-therapy for the ordinary methods and rules of Hygiene We le&d (ibid, 0.11739) that "In Heubner's Clinic from 1895 onwards, prophylactic injections were given every three weeks to all the patients ; and the outbreaks of diphtheria, which had formerly regularly ocurred in the wards came to an end."— (N.B. The italics are not in the Blue-Book.) ' * The ordinaiy dose of sulphurous acid for adults was a drachm, diluted with water and syrup. The mixture has an agreeable taste which recommends it to children. In 20 years of practice, I never knew the treatment fail but once. Then a patient, who had been cured, again exposed herself to the foul odour which had brought on the disease ; was seized by uncontrollable vomiting and died without any return of the Diphtheria. I was lately much gratified to find my experience confirmed by Dr. Stenson Hooker. « 26 (c) Other Anti-toxins. Snake Venom. Compared with the preceding, the claims of other serum-treated maladies to prove special success by that method are feeble ; and mostly of the '' Ugitimes pro- messes'' order. Such are tetanus, dysentery, typhoid fever, plague ; with snake-bite. Of the TETANUS-ANTITOXIN Prof. C. J. Martin (ibid. 11740) admits that "As a curative agent in practice, its value is far less than that of the corresponding Anti-toxin of diphtheria, because the disease is only discovered after serious lesion of the nervous system has been produced, upon which unfortunately the A. can exert little influence/. And again (11744) ^^t (the Tetanus-Antitoxin) is not very hopeful under any circumstances." Statistics quoted by the same eminent and candid witness who, as Director of the Lister Institute, may be held the official Protagonist of British Vivisection— directly controvert each other. The normal death-rate from Tetanus is stated to be 86 per cent. Koehler, of 96 cases treated with Anti-toxin, reports recovery in 30*4 per cent. On the other hand Steur from his figures could " demonstrate no improvement " over cases treated without Anti-toxin. However '^ as a prophylactic the power is fully estab- lished " (1 1 749) I The proposition is proved by reference (Q. 11751) to 2700 horses. Fortunately no one has yet attempted to demonstrate these preventive virtues on the human subject."^ The Anti-toxin of dysentery evokes the following : '' No extensive data as to Man are yet available ; but so far as it has been used the results have been of a very promising character "— /bid.q. 11758 (N.B. No italics in Blue-Book.) This refers both to cure and to prophylaxis. ♦That is, to the best of my knowledge. But the statement is liable to correction. H.S, 27 On the ANTi-'fYPHOiD SERUM (ibid. 11799) '' The statistics concerning the campaign in South Africa which have been collected together by the Army Medical Department indicate a substantial diminution both of the incidence, and deaths from typhoid fever among the inoculated." On investigation it is difficult to discover any reason- able grounds for this eulogistic statement. The S. African figures quoted are mostly too smaU for any useful purpose. But of the Ladysmith garrison, a case-mortality of 20*3 percent among 1705 inoculated — against one of 22*1 percent, among 10529 uninoculated — assuredly fails to shew '* substantial diminution." Another series of cases (ibid. 11794) shew a preponder- ance in the opposite direction. Five deaths among 27 inoculated against 23 among 213 not so '* protected'' — a mortality of about 1 in 5 in the former case, only 1 in 9 in the latter. In spite of the very pronounced official leaning to- wards serum-therapy, — we are told (11803) that ''con- siderable effort is being made by the Commander-in-Chief in India to secure the inoculation of as large a pro- portion as possible of the British Army in India,'' — civilians attacked by typhoid will probably prefer less " up-to-date "' methods of treatment.* The system of prophylactic inoculation with Anti- Plague sera, has been officially adopted by the Govern- ment of India ; and a former Viceroy, Lord Curzon, has publicly eulogised Haffkine, the pioneer thereof. It began in 1897 ; and no effort to secure its general adoption by the Medical Faculty throughout India would seem to have been spared. * As throwing light on the theory of causation by microbes. Dr. Thresh in the Malvern Hydro Case told the Court that he had once swallowed by mistake a tumblerful of water full of typhoid bacilli without ill effect (Daili/ Telegraph, Jan. 25th, 1908). Dr. Kleiu once purposely swallowed a glass of cholera bacilli without harm, in order to prove his disbelief in Koch's discovery. 28 Yet in 1905, there were 1,040,429 deaths from the plague,— over 350,000 in the Punjab alone. This was among the natn^s. It is significantly admitted (11935) that before Haffktne's treatment was introduced, " cases A PiT^ T''^ comparatively very fewamong Europeans." And that (11.930): "the general mortality from plague among the European population in India has always bten Thus the annual death-roll is enormous and, although like aU epidemic waves those of Plague fluctuate m virulence shews no present sign of diminution, ilie proffered inoculation statistics (ibid, 11792) are much the reverse of convincing. They usually indicate a small balance of seeming success (ie, in projyhylaxis,- there ts here no question of cure). But inconsiderable m any event that is assuredly far below what would appear, were the pretensions of either Haffkine or Yersin warranted by genuine Science ; and their Sera of real value. But Indian Plague-inoculations remarkably serve to Illustrate the academic character of ordinary vivisection- methods ; which habitually substitute deduction from assumed, or at any rate from non-proved, facts for the guidance of experience and observation. The plaeue origmates and is ever rife in huts built of mud w!jls upon an earthen foundation. The native villages consist of these thickly crowded together upon soil reeking with pestiferous germs,— a veritable mushroom-bed for the mahgnant niicrobe. The walls are crumbling and porous • into them the sun's heat draws up the foul air as into a ventilating shaft. Here is a perpetual nidv^ of plague- epidemics; and none can wonder. (See paper read by Dr. Charles Creighton before the Indian Section of the Society of Arts). Instead of attacking this state of things in the manner which ordmary prudence would suggest,-the attention ot the Indian Government, under Vivisection-direction IS entirely devoted to rats and fleas ! The association of 29 these creatures with the plague is problematical, and at the moat, highly obscure."*^ But they naturally lend them- selves to the practices of the Vivisector ; and to copious " legitimes promesses pour V avenir^ The total failure of Serum-therapy for Snake- Venom is generally admitted; although the medical expert examined by the Royal Commission naturally lets the much- vaunted Antivenin down easily. He says : '* Although the Antivenin has a decided protective influence, it is not practically of very great use." (Major L. Eogers, Q. 8035). One of the practical difficulties in detail, is that every species of poisonous snake appears to need, for the neutralisation of its venom, a special serum. In a country like India, it is rather difficult to keep on hand a complete stock, — especially as each should be freshly prepared. Calmette's applies to the cobra only ; and is not admitted by Sir Lauder Brunton to have cured a single case of cobra-bite. How then stands the up-to-date Balance-Sheet of Serum-Therapy ? On the Credit side, but a very scanty and partial measure of success ; on the testimony of its most zealous advocates. Even that small modicum must be subjected to such heavy discounts or deductions in manifold directions, as ultimately to become altogether eflkced. The auditor has to make allowance for the statistical inclusion of dubious cases ; for the enthusiastic zeal of credulous and non-scientific votaries ; for the large pecuniary interests involved (these substances are now an important article of trade), for the well-known curative influence of * There are three varieties of rat at Calcutta — the black, the mole-rat, and the brown. The two former are supposed to propagate plague, the latter not. So Sir B. Ray Lancaster, writing in the Daily Telegraphy considers the proposed crusade against our common brown rat a great mistake. It has probably protected us by driving away the black, which is a house-rat ; whereas the former inhabits the sewers. so powerful mental impressions, as in Faith-healing, and so on. Foremost of all however counts the point mentioned in the Introduction ; that every Anti-toxin contains some chemical or other, endowed with precious thera- peutic properties, — to which whatever value may attach to the serum must be ascribed. The omission of this wholesome ingredient has involved notably disastrous consequences. In 1902, nineteen villagers at Mulkowal were inoculated with Haflfkine's plague-serum, from which the carbolic acid had been omitted. All died — of tetanus, not of plague ! And then per contra, what have we ? A very con- siderable sum of avowed and notorious Failure ; a still larger of Failure, secret and never to be disclosed, — folks don't proclaim such things from the house-tops ! And finally, such loss to mankind by the diversion of Medicine from Nature's clearly prescribed paths, as future ages alone can estimate ; when the reversionary method of Vivisection has been finally discarded.'*^ V. Cancer. Consumption. The Drug Factory. The other spheres of Vivisection-activity hardly de- mand more than passing mention. To the non-credulous eye, failure is sufficiently obvious along the whole line. * " Reversionary^ For the study of Anatomy the medical students at Salerno, the great medical school of the Middle Ages, dissected only " the bodies of swine ; as likest the human form divine." — Longfellow, Herophilus and Erasistratus, according to Galen, dissected 600 livijig men and women. In Egypt, criminals were assigned for the purpose ; as also at Pavia, in the Middle Ages. An American doctor has just openly advocated a return to this arrangement. It is almost incredible that the great Lister should have proclaimed at Berlin in 1890, thai it had now become necessary to experitnent 07i Men. — See British Med. Journal, Aug. 16/90, Address at Berlin Congress. 31 The last-named is the one most densely obscured by ** Octopic " clouds. It serves to indicate the huge com- mercial interests, now enlisted in the Vivisection cause. The extensive mice-inoculations undertaken in refer- ence to cancer by the Imperial Research Fund are simply a rediictio ad absurdum of Vivisection argu- ments and modes of thought. Because certain maladies associated with micro- organisms are believed to be cured by serum-treatment, it is assumed that a remedy of the same class may also cure Cancer, which has nothing whatever in common with microbic disorders. A vigorous search for an " Anti-toxin Cure" is promptly initiated. "^ It is found that a certain Tumour affecting mice can be transferred from one mouse to another. The nature of the growth is problematical ; though many similar formations in other animals,t long believed by medical scientists to be cancerous, have eventually proved due to a fungus. A microscopic thin section, however, resembles one of cancer. So although the microscopic indications of that malady are notoriously unreliable and fallacious,! the mouse-tumour is forthwith assumed to be cancer ; and, furthermore, to be identical with the cancer of human beings. In the quest of serum-cure for that scourge, mice innumerable are promptly slaughtered. * The phenomena of Cancer are in every respect curiously unlike those of every disease in which a micro-organism has been discovered. The fact renders causation by a microbe highly improbable, if not altogether impossible. f AMiO'Mycosis, the Rag Fungus, which attacks cattle, was long considered a cancerous growth. The Report of the l.C.R. Fund which describes the mouse-experiments, gives an account of a similar tumour in dogs. There are many more of the same class. I It is most dangerous to base a diagnosis of cancer in Man on microscopic evidence alone. Clinical signs should always rank first. The microscope can only corroborate. It cannot always even dis- prove. Witness the sad case of the Emperor Frederick. iiasSi.- *-:: 32 It is needless to add that there has hitherto been no result ; and that benefit to science in the future can hardly be anticipated with confidence. For, at the out- set two main points, beside sundry minor ones, combined to differentiate the mouse-malady from human cancer for any one who possesses more than academic know- ledge of the latter. There is no perceptible analogy whatever. (a) The tumour sometimes disappears spontaneously. This no true human cancer has ever been known to do, (b) A mouse carrying one of these ''Jensen's Tumours" far exceeding its whole body in weight, will run about without any sign of pain or suffering. The health and vitality are apparently quite unimpaired. For magnitude of operation-sphere the Eoyal Com- mission on Tuberculosis probably bears the record— as perhaps also for relative paucity of practical results. That body has occupied five years, and two separate farms beside the laboratories, in a research merely pre- liminary. The list of animals comprises cattle, goats, pigs, dogs, guinea-pigs, rabbits, and monkeys with the chimpanzee. The Eeport shews no new fact. It merely goes to contradict the improbable assertion of Professor Koch that animal tuberculosis is distinct from the human and cannot be communicated to man. This negative, so far as it may be supposed to go, has done nothing to further the better treatment— or even the better abstract knowledge— of Consumption, Both these grandiose Vivisection-schemes have how- ever succeeded admirably in ''trailing a red herring across the scent": that is to say, in diverting attention and intellectual force from the true path. The Cancer investigations have only served to perpetuate that utter contempt of Cancer-Science, which, combined with a hopeless and unfounded pessimism, pervades all the ranks of Medicine, from the highest to the lowest. They tend to prevent its reform by improved medical education ; one of the most crjdng needs of the time. (fi) See the Eeports of the Imperial Cancer Research Fund, 38 The Tuberculosis inquiries have merely focussed both public and medical gaze on two points— (a) The Tubercle Bacillus; (6) the Milk Supply. Now the microbe, though casually associated with Consumption-phenomena, does not appear to be invariably so. Neither has it ever been shewn to be either the cause of Consumption, or per se the vehicle of contagion, — whenever the malady is contagious, an event which Sir Douglas Powell, a high authority, regards as exceptional. (R.V. Commission, Q. 5783 et seq.) As to the latter question, there is evidence that children can be fed on the milk of tuber- cular cows for years, without any impairment of health. (Dr. Holt, in Medical News,) Hence, neither of these matters can be regarded as highly material to the vital point at issue, the extinction or cure of Consumption, the ''White Plague." The attainment of that aim plainly turns, not upon the fantastic hypotheses of Bacteriology,^ but on the reverent observance of Nature and her ways,— not upon the hypodermic syringe, but on questions of fresh air, pure food, wholesome dwellings, light, a sound physical foundation in childhood, and so forth. The evidence of Prof. Cushny before the Royal Com- mission is particularly instructive in shewing : (a) The enormous trade in "Synthetic" drugs intro- duced by Vivisection. {b) The unpractical views of disease current, through the same cause, among the younger practitioners. (c) Their tendency to view everything connected with the Healing Art, through Vivisection-spectacles ; * To the Science of Bacteriology in the hands of the latter-day Bacteriologist, Tennyson's verse : " A lie which is half a truth is ever the blackest of lies" applies with peculiar force. The microbic part of Bacteriology (dealing with germs and their phenomena per se) is Science. The medical element (that which concerns the application of micro-organisms to the purposes of the Healing Art) is mostly, if not entirely, Fiction. 34 to credit no novelty introduced into practice, unless based on living-animal experiment.* So highly does the Chemical industry value the aid given in this way (ie, by Vivisection) "that its leaders . have appointed pharmacologists and erected laboratories for animal experiment at the cost of many thousands of pounds per annum/' (Q. 4819). Most of the laboratories referred to are in Germany, Germany, the land of incomparable industry in minute details ; also par excellence of Vivisection, of medical and physiological " Octopism/' Space does not permit a detailed discussion of the chemicals. But no candid (general) practitioner of experience will decline to admit that any commensurate improvement in the treatment of disease is wholly wanting ; that only one of the drugs, here and there, has value ; that the majority are far inferior to those previously in use ; that many are deleterious or even dangerous ; that on the most favourable estimate of the 1 4 large groups described by Prof. Cushny we have a single grain of wheat among many bushels of chaflp. The most ardent Vivisectionist would have difficulty m proving that the sum of human suffering has been appreciably lessened, or even a single death averted by the introduction of Heroin, Urotropin, Thallin, Ortho- form, Paraldehyde, Ureihane, Veronal, Sulphonal, Trional, et hoc genics omne. This very able witness may be aptly regarded as typifying the Vis Academica of Vivisection. No practical man of Medicine would endorse his remark : (Q. 4711) ''I would suggest that the usefulness of Pharmacology lies in breaking up disease into symptoms, each one of which can be treated with drugs when those * Witness the idea that Digitalis, a very old established remedy for Heart-disease, is a modern Vivisection -product. It was the remedy when I was a student, 1863. Yet Professor Cushny refers its use for cardiac maladies to a Vivisection-Research by Traube and Brunton, about that epoch ! 35 symptoms are present ; instead of treating the whole disease with drugs." Surely that idea must touch the supreme height of academic folly. ''^ VL Conclusion. Suggested Lines for Future Research. It has become increasingly evident how completely the cruel, misleading, and futile system of Living- Animal Experiment is supplanting the only method whereby all valid progress in the Art of Healing — from the days of Hippocrates down to Harvey,t Sydenham, Trousseau, Lister — has been achieved. That method consisted in vigilant observation by the bed-side and in the mortuary : combined with carefully reasoned deduction from the facts perceived. Also that the vast aggregate of animal pain and anguish which since Claude Bernard's confession have gone on accumulating at an ever increasing ratio, have not actually added to practical medicine one jot or tittle of good. For those who look under the surface, there can be no more convincing proof of this than the testimony, before the sitting Commission, of all the foremost Vivisection-advocates (See final note.) The first step therefore obviously indicated — after the Abolition of Vivisection — would be a Eeform in Medical Education involving return to the old wise paths : developing sympathy as well as cold, hard * Even Professor Cushny is compelled to admit (Q.5249) " I think there is no question that a large number of these new remedies are no advance upon those formerly used." Also (4963-4) that no experiment on the living animal is ever final and complete. f Harvey, although a Yivisector did not on his own shewing, thus discover the Circulation of the Blood. Moreover no physiologist would resort to experiment on the living animal in order to demon- strate it. This IS universally admitted. Under the microscope one can easily witness the phenomenon in the web of the frog's foot. But that involves no experiment. 36 knowledge ; promoting development of the reasoning and perceptive faculties ; really making for practical efficiency in the cure, relief, or prevention of Man's physical ills. The total prohibition of living-animal experiments per se, would unquestionably constitute a healthy stimulus to medicine, of inestimable value to mankind. Since the extinction, fifty years ago, of the apprentice- ship-system, the training of the student has become more and more academic ; until under the Upas shadow of Vivisection, a practical acquaintance with the proper medical ^ details of his profession has finally become all but impossible, — certainly very unnecessary. He must pass the examinations. For those, he can learn almost everything required from books. Anything beyond is rather detrimental than not, as tending to encourage scepticism and originality, — qualities not favoured by the average examiner, medical or other. By the apprenticeship method, every young man was bound to acquire an intimate acquaintance with illness in its every day forms , — a totally difierent matter from the picked cases of disease seen in the hospital. Also what was perhaps of hardly less importance, he was brought into far closer contact with human misery, human emotion, human weakness, and human strength than is ever remotely possible in the crowded and artificial hospital ward. That method has gone, and it would be idle to attempt its revival, — were such desirable, which is not the case. If however the custom were still in existence, we should hardly find the present almost universal disposition to credit any preposterous Vivisection-fallacy. We should not see eminent surgeons or physicians professing utter disbelief in drugs ; and prophesying the extinction of medical pills or potions in the near future. They do * The surgical details are not included. The Art of Surgery has become elaborately perfected, as all men know, in these latter days. ! 37 this, because it has never been necessary for them to know anything about the subject. The knife is the weapon of the Surgeon, Faith-healing is the magic wand of the Physician. With the homely ** family doctor'' matters stand quite difierently. He is forced to dis- regard humbug and look at things as they are. The public would hardly credit the insignificant attention paid to medical treatment by the educational bodies in this best of all possible worlds. The teachers openly disregard or contemn it. They themselves have never learnt it. Take up the Pharmacopoeia, and you find it crammed with absurdly complex '' washing-bill " preparations and more or less preposterous drugs. Pick up a medical text-book and you are confronted with abundant prescriptions for any particular disorder ; from which you are at liberty to pick and choose at your own sweet will.=^ There is nothing to tell you which is good and which is bad : what is true, and what is false. There is no machinery for sifting the wheat from the chafi". Every young practitioner has to do that for himself. Experto crede. I have been through the mill. I do not think it would be Utopian to enact a rule which would procure the chief object aimed at by the old plan without any of its disadvantages. That object was to familiarise the practitioner with sickness amid the daily life of the people. It could be even better secured by an academic curriculum first of all. Then several years should be devoted to a probation more or less under the conditions of what is termed " general practice.'' Not until those had elapsed should the aspirant receive his full diploma. Much less should he be placed on a hospital staff or be permitted to teach. It is un- necessary perhaps to add that, as at present constituted, such a proposal might be expected to meet the most * This is probably one reason for the vogue of Diphtheria- Anti- toxin. I remember the text-books previously ;— full of useless remedies, of which a single trial served to prove the ineflaciency. Occasionally the patient survived that trial. 38 strenuous opposition from all the Principalities and Powers of Medicine. Secondly comes the question of Eesearch-Work in the Laboratory. The great problem of Life itself, so far as that may be supposed to fall within the range of our finite intellect, depends for solution upon our acquaint- ance with the real nature and properties of Protoplasm, the name given to the living jelly which constitutes a cell. The cell is the unit of all animated things. Our complex tissues and organs were once potentially en- shrined in a single cell. Subsequently that gave birth to innumerable others. Some of these in turn underwent metamorphosis into the formed tissues, though many (or rather their off- spring) persist as simple cells till the end. Now certain animalcules, such as the little Amoeba of our ponds, never pass beyond the first mono-cellular stage. The embryonic cells from which the human body was elaborated are, to all intents and purposes, and so far as we know, identical with the Amoeba. Both are com- posed of this Protoplasm. Both behave exactly alike, can move about independently, can absorb or reject nutriment, &c. The human cells were once upon a time practically independent organisms. Many still remain so. Cancer-cells are once healthy cells which appear to have become so anew — have in fact reverted to the embryonic type. Did we know what Protoplasm is, and why it behaves so mysteriously under different circumstances, we should possess a key to all the infinitely varying phenomena of Health, of Development, of Disease. But unfortunately the word is merely a verbal expression. We are absolutely ignorant of the stupendous facts it denotes ; or rather serves to conceal. In order to acquire such knowledge as we may on this most vital point, the Science which is the most highly evolved Common Sense will naturally devote its attention primarily to the lowest forms of life, — 39 particularly of animal life. It will study the growth of unicellular organisms in health. It will then consider their variation under conditions of disease, artificially produced. Thence it would pass on to investigation of the laws which govern the combination of cell-units into organised beings higher in the scale, such as the Sea- Anemone or the Ascidian. The next great step would be to ascertain if possible how such cell-aggregations become subordinated to control by Nerves,— in other words, the relation of Pro- toplasm to Ganglia, or other nerve-centres. Development and Function are regulated by the Nervous System of the animal; whose health primarily depends on the well-being of its nerves. Almost all disease-phenomena in ourselves, whether of intrinsic or extrinsic origin can be traced to some nerve-aberration in the first instance. Those of Cancer in the most prevalent forms of that highly complex malady, pre-eminently illustrate this.'^ *The coming race of medical investigators will learn how to explore widely the hidden arcana of Natural forces as yet hardly touched ; and pushed on one side by the current Vivisection vogue. Such are Electricity, Radiant energy, with the unknown " Psychic Forces," of which telepathy and the dowser's rod offer faint suggestions ; to say nothing of Hypnotism, the '' Sub- liminal Consciousness," and all those mysterious phe- * Ten leading varieties, or genera, 13 minor ditto, or species, of Cancer are described, besides numerous less important kinds. Their phenomena turn on the properties of their cell-elements. These according to the Autositic Theory, the only one which plausibly explains all Cancer-phenomena, are cells emancipated from control by the nerves. Most cancers own a neurotic cause e.g. trouble and ^ The extrinsic causes of disease, such as microbes and parasites, are most prone to attack the sickly. Malaria follows a chill, t.e. a nerve-shock, or condition depressing the nerve-centres. Parasites seize on the weakly animal, as they do on the previously languishing plant Huxley's well-known phrase '' Good animals first, implies appreciation of this point, too often lost sight of by modem civiliza- tion. 40 nomena of like order so glibly explained away by modern Science in hollow verbal phraseology which only Makes still darker What was dark enough before. Research among the lower organisms is however the main path to be followed by Medicine and its professors in the ages yet to be. That could shock no sentiment of humanity, for it would not inflict a single pang on any sentient creature. It would stop far short of animals endowed with such a highly-developed nervous system as to feel pain. Experiment on them would be needless and superfluous. Having once found a clue to the ultimate mysteries of disease, those which concern the cell-unit and its nerve-control, observation and ex- perience may be relied on for the rest. Such an enquiry has become almost the sine qua non of further progress in Healing Art ; and to that, the Abolition of Vivisection is an essential preliminary. In conclusion it may be well to remember the pregnant words of the great surgeon with a recital of whose work this essay began. " Some day I shall have a tombstone put over me, and an inscrip- tion upon it. I want only one thing recorded on it, and that to the effect that he laboured to divert his profession from the blundering which has resulted from the performance of experiments on the sub- human groups of animal life, in the hope that they would shed light on the aberrant physiology of the human groups. Such experiments never have succeeded and never can ; and they have as in the cases of Koch, Pasteur, .... not only hindered true progress, but have covered our profession with ridicule." — Lawson Tait, Letter in Medical Press and Circular j May, 1899. (The italics are not in the original.) Intcriiatioiial Medical Anti-Vivisection Association. BRITISH SECTION. Advocates of Vivisection before the Royal Commission. These mostly content themselves either with ipse dixit state- ments of the benefit it confers ; e.g. Sir Victor Horsley and Brain- Surgery : or like Professor Osier with Yellow Fever, cite voluntary experiments by men on themselves : or thirdly, like Colonel Bruce in re Malta Fever, give discoveries procured by examination of the blood, milk, &c., not by Vivisection at all. Central J6jecutl\?e Committee. Herbert Snow, Esq., M.D, M.B., Chairman. J. T. ASHTON, Esq., M.B., CM. E W. Berridge, Esq., M.D., M.B. Miss Helen Bourchier, M.D. G. H. Burford, Esq., M.B., C.xM. J. Burns-Gibson, Esq., M.A., M.D. W. J, Cameron, Esq., M.B., Ho?i. Treasurer, T c r. ^3, Park Street, Park Lane, W. J. Stenson Hooker, Esq., M.D. Miss Arabella Kenealy, L.R.C.P. S A Stoddard Kennedy, Esq., L.R.C.P., L.R.C.S H. Valentine Knaggs, Esq., L.R.C.P., M.R.C.S. D. MacNish, Esq., M.A., M.B., CM. JOHN Shaw, Esq., M.D., M.B. Stephen Townesend, Esq., F.R.CS. Miss Lind-af-Hageby, Hon. Secretary, 224, Lauderdale Mansions, Maida Vale, London, W. Extraci from the Rides for the British Section of the hiternational Medical A nti- Vivisection Association, All men and women holding a Degree or Diploma in Medicine or Surgery m Great Britain and Ireland or who, residing in Great Britain and Ireland or the Colonies, having qualified elsewhere approve of and are willing to suppoit the objects of the Association can beco4iie members of the British Section of the International Medical Anti- Vivisection Association. The minimum subscription of members shall be 2\(i per annum. * * * * LAY ASSOCIATES. Lay Anti-Vivisectionists who are anxious to further the special objects of the Association may join the British Section as Associates on payment of an annual subscription of not less than 10/6. Associates shall be entitled to a copy of each of the publications of the British Section, and to special notification of lectures and meetings, but shall not be entitled to a vote at the General Meetings of members. ° 40 nomena of like order so glibly explained away by modern Science in hollow verbal phraseology which only Makes still darker What was dark enough before. Research among the lower organisms is however the main path to be followed by Medicine and its professors in the ages yet to be. That could shock no sentiment of humanity, for it would not inflict a single pang on any sentient creature. It would stop far short of animals endowed with such a highly-developed nervous system as to feel pain. Experiment on them would be needless and superfluous. Having once found a clue to the ultimate mysteries of disease, those which concern the cell-unit and its nerve-control, observation and ex- perience may be relied on for the rest. Such an enquiry has become almost the sine qua non of further progress in Healing Art ; and to that, the Abolition of Vivisection is an essential preliminary. In conclusion it may be well to remember the pregnant words of the great surgeon with a recital of whose work this essay began. '* Some day I shall have a tombstone put over me, and an inscrip- tion upon it. I want only one thing recorded on it, and that to the effect that he laboured to divert his profession from the blundering which has resulted from the performance of experiments on the sub- human groups of animal life, in the hope that they would shed light on the aberrant physiology of the human groups. Such experiments never have succeeded and never can ; and they have as in the cases of Koch, Pasteur, .... not only hindered true progress, but have covered our profession with ridicule." — Lawson Tait, Letter in Medical Press and Circular, May, 1899. (The italics are not in the original.) '4* Advocates of Vivisection before the Royal Commission. These mostly content themselves either with ipse dixit state- ments of the benefit it confers ; e.g. Sir Victor Horsley and Brain- Surgery : or like Professor Osier with Yellow Fever, cite voluntary experiments by men on themselves : or thirdly, like Colonel Bruce in re Malta Fever, give discoveries procured by examination of the blood, milk, &c., not by Vivisection at all. I \i International Medical Anti-Vivisection Association. BRITISH SECTION. Central iejecuti\?e Commtttee^ Herbert Snow, Esq., M.D., M.B., Chairman. h T. ASHTON, Esq., M.B., CM. E W. Berridge, Esq., M.D., M.B. Miss Helen Bourchier, M.D. G. H. BURFORD, Esq., M.B., CM. J. Burns-Gibson, Esq., M.A., M.D. W. J. Cameron, Esq., M.B., Hon. Treasurer, T c XT ^3, Park Street, Park Lane, W. J. Stenson Hooker, Esq., M.D. Miss Arabella Kenealy, L.R.C.P. S. A Stoddard Kennedy, Esq., L.R.C.P., L.R.C.S. S* y/^^?'^^^^ Knaggs, Esq., L.R.C.P., M.R.CS. p. MacNish, Esq., M.A., M.B., CM. John Shaw, Esq., M.D., M.B. Stephen Townesend, Esq., F.R.CS. Miss Lind-af-Hageby, Hon. Secretary, 224, Lauderdale Mansions, Maida Vale, London, W. Extract from the Rules for the British Section of the International Medical Anti- Vivisection Association. All men and women holding a Degree or Diploma in Medicine or Surgery m Great Britain and Ireland or who, residing in Great Britam and Ireland or the Colonies, having qualified elsewhere approve of and are willing to suppoit the objects of the Association can becoiiie members of the British Section of the International Medical Anti- Vivisection Association. The minimum subscription of members shall be 2/6 per annlim. * * ♦ ♦ LAY ASSOCIATES. Lay Anti-Vivisectionists who are anxious to further the special objects of the Association may join the British Section as Associates on payment of an annual subscription of not less than io/6. Associates shall be entitled to a copy of each of the publications of the British Section, and to special notification of lectures and meetings, but shall not be entitled to a vote at the General Meetings of members. ° m Financiai Support Urgently Needed. V i 'll •^ J/ / i i**i»i,!*»,%-^K;S&B.iK; <^#,-s J X I i I I I V 1