Columbia Wini\)tv^itv in tije Citp of jBteto gorfe '" ' ^cliool of ISental anb d^ral ^urgerp ( O: c . 3^eference %ihvaxv 4 jt-^' Cl'i Digitized by the Internet Arciiive in 2010 with funding from Open Knowledge Commons http://www.archive.org/details/lecturesongenera1912defo DR. HORACE WELLS. Discoverer of Siiroir-;i] AnBcsthesia. (Nevius) LECTURES ON General Anaesthetics IN Dentistry Advocating Painless Dental Operations By the use of Nitrous Oxid, Nitrous Oxid and Oxygen, Chloroform, Ether, Ethyl Chloride and Somnoform BY WILLIAM HARPER DeFORD, A.M., D.D.S., M.D. Dean and Professor of Oral Pathology and Ansesthetics, Drake Uni- versity College of Dentistry; Late Professor of Oral Patholoev Surgery and Hygiene. College of Dentistry, State University of Iowa; Formerly Professor of Oral Pathology, Drake Univeraitv College of Medicine; Member National Dental Association: Member and Ex-President Iowa State Dental Society; Member The New York Society of Anaesthetists; Honorary Member Missouri Kan- sas, South Dakota and Colorado State Dental Societies and the Rn.^rt°"„'f ^'"■l''7t^°^ ^f"^"*' ^^^'^^^'^^ Ex-President Iowa State Board of Dental Examiners, etc., etc. SECOND EDITION WITH ILLUSTRATIONS LEE S. SMITH & SON COMPANY PUBLISHERS Pittsburgh, Pa. 1912 Copyrighted, 1912, By LEE S. SMITH & SON CO. DEDICATION To JESSIE RITCHEY DeFORD, D.D.S., In recognition of her ability as a skilled anaesthetist and valued co-laborer, I dedicate this volume. PREFACE TO SECOND EDITION. The fact tliat a book is well received is more gratifying to an author than financial returns. The first edition of this book was exhausted last summer, and since that time there have been more inquiries and orders for the book than at any time during its existence. This in itself would be a suf- ficient reason for another edition. A better reason, however, is the fact that during the past few months a number of anaesthetic appliances of superior design have been introduced, greatly simplifying the admin- istration of anaesthetics, making the administration of anaesthetics less hazardous, and securing more grati- fying results for both patients and operator. The manufacturers of nitrous oxid and oxygen have revolutionized their method of handling these agents. It is possible now to obtain cylinders con- taining from twenty-five gallons to thirty-two hun- dred gallons of nitrous oxid and the amount of oxygen corresponding. The larger cylinders are equipped with pressure gauges, insuring an even and constant flow of the anaesthetic at all times. A table in conjunction with an indicator showing the number of gallons remaining in the cylinders relieves the anaesthetist of the anxiety formerly experienced every time an administration of nitrous oxid and oxygen was to be made, lest the cylinders might not contain a sufficient quantity of material to complete a given case. 1 2 Preface to Second Edition. The fact that nitrous oxid can now be obtained in such large cylinders, that the gas can be made to flow steadily at a given pressure, and a gauge has been devised indicating at all times the amount of gas remaining, overcomes in a measure the objections to nitrous oxid-oxygen anaesthesia. Since the last edition of this book was issued the somnoform formula has been revised, making it theoretically safer but in no way diminishing its efficiency as an anaesthetic agent. A new somnoform appliance has been devised, increasing the possibilities of this anaesthetic. By means of this appliance, when the stage of analgesia or anaesthesia is reached, it is no longer necessary to remove the appliance from the face, but the patient continues to inhale the anaesthetic through the nose, thus maintaining the stage of anaesthesia or analgesia desired. Recent investigations of Yandell Hender- son and others showing that instead of being a waste and deleterious product carbon dioxid is one of the most important of the body's hormones, "exercising a regulating influence on the action of the heart, on the tonus of the blood-vessels, and especially on respiration," is the most important discovery in half a century in the realm of anaesthesia, and bids fair to revolutionize anaesthetic administration. In the light of these advancements we feel that another edition of this book is justified. Drake University, Des Moines, la. W. H. DeFORD. June, 1912. PREFACE TO FIRST EDITION. At the request of Dr. Burton Lee Thorpe, associate editor of The Dental Briefs the writer prepared for that journal a series of articles entitled "Anaesthetics in Dentistry." From time to time during their publica- tion numerous letters were received from all over this country and abroad inquiring if these articles would be published in book form. So many inquiries of this kind have come to hand as to create the impression that a practical treatise on anaesthetics was very much needed. Instead of repro- ducing in book form what has already been printed in the Brief, the author has used those articles as a skele- ton about which he has woven the fabric which consti- tutes these brief lectures. The object of this book is to give the busy dentist a working knowledge of such general anaesthetics as can be used to advantage in daily practice. With this end in view, the author has prepared what he has to say in the form of brief lectures. The "how" is dwelt upon more than the "why" ; in other words, it is simply a practical treatise, and not a theoretical exposition. The lecture style enables the author to talk directly to the individual just as is done in the class-room and to repeat and emphasize from time to time the more important and essential things, which is not permissible in a text-book. 3 4 Preface to First Edition. Hewitt has been quoted frequently ; his text-book, entitled "Anaesthetics/' in my opinion, is the best that has ever been written on this subject. Brunton, Luke, Buxton, Crile and others have been consulted, and, likewise, papers and clinical reports published in The Medical Association, current literature in medical and British Medical Journal, Journal of the American dental journals, etc., etc. The author is also indebted to the S. S. White Dental Manufacturing Company, E. de Trey & Sons, the Lennox Chemical Company, A. C. Clark & Company, Teter Manufacturing Company, and Dr. Laird W. Nevius for the cuts of the various dental appliances used in these pages. W. H. D. Hotel Victoria, Des Moines, Iowa, April, 1908. CONTENTS. LECTURE I. Has the Dental SuRtJEox the Hight to Administer CiENEitAL Anaesthetics ? Page I'utoiitiality of the doiital iliploiiia. — Kmployiiient of drugs otlier than aiui'sthetics. — The oldest dental college in the world. — Dr. Chapin A. Harris endeavors to establish chairs of operative and mechanical dentistry in the Maryland University Medical College. — Dentists may become mem- bers of the American Medical Association. — The dentist should surround himself with every possible safeguard. — Dentist would not be liable for a death which might re- sult. — Dentist is not held to insure the result of his work. 13 LECTURE IL The Value of General An.^isthetics to the Dental Surgeon. Ana'sthetics are employed to prevent pain and to avoid shock. — Dangerous to submit patients to intense pain be- yond certain limits. — Employ anaesthetics to facilitate operating. — Saves the patient suffering and nerve strain. — A visit to Dr. Austin C. Hewett 's office. — Conditions in which general antesthetics can be used to advantage.... 21 LECTURE IlL To Whom Is It Safe to Administer an Anesthetic? Invalids and patients in poor health usually good subjects.— Opinions of Ochsner, Luke, Richardson and Brunton. — Ether and chloroform contraindications. — The strong, healthy and vigorous more liable to accidents than the weak and frail. — Inexperience, ignorance and carelessness responsible for deaths. — Importance of watching respira- tion 31 LECTURE IV. Elements of Danger. In civic matters, ignorance of the law excuses no man. — Deaths result from ignorance of ana?sthetic sj-mptoms and stages. — Medical and Dental Colleges are at fault. — Case illustrating ignorance. — Anaesthetics in themselves not so dangerous as ignorant anaesthetists. — Carelessness 5 -h 6 Contents, Page of hospital authorities. — Alice Magaw. — Buxton and Galloway arraign Medical Colleges. — Length of duration of angesthesia an element of danger 40 LECTURE V. Shock. Shock defined. — Causes are psychical and physical. — Psychical causes defined. — A death from shock. — Deaths resulting from fear. — Chloroform experiments on plants and ani- mals. — Shock resulting from external pressure. — Anaesthe- sia induction before the introduction of general anaes- thetics. — Many who are hung and drowned die from shock. — External pressure exerted by clothing. — Spasms of the glottis.— Death resulting from blood collecting in the throat. — Nausea during nitrous oxid administration. — Shock and death resulting from operating during par- tial anaesthesia. — Chloroform idiosyncrasy 50 LECTUEE VL Dental Fatigue. Dental fatigue and shock differ only in degree. — Dread of dental operations. — Illustrative cases. — Handling of such patients. — Nitrous oxid, somnoform, ethyl chloride, or chloroform recommended. — Christian Science. — Case of a Christian Science healer. — Hypnotism. — Hypnotism illus- trated. — Cases illustrating dental fatigue and their treat- ment 67 LECTURE VII. Elements of Success. The operating-room. — The rest-room. — Preparation of the patient by the assistant. — Remove corset in all cases. — Attention to bladder. — Allay fear. — Suggestion. — Illustra- tive case. — Assistant's duties. — Never anaesthetize a woman without witnesses. — Illustrative case. — Importance of quiet in operating room. — Suggestion after operating. — Prevent blood from being swallowed. — Objections to hurrying resuscitation. — Dental chair responsible for many failures. — The best anaesthetic chair 79 LECTURE VIIL Relative Safety of General An^sisthetics. Nitrous oxid and oxygen the safest of all anajsthetics. — Chlo- roform the most dangerous. — Statistics prepared by Jul- llard, Ormsby, St. Bartholemew 's Hospital, Luke. — Unre- liability of statistics. — Teter's prolonged case of anajs- thesia. — Nitrous oxid and oxygen handicapped. — Som- noform. — Ethyl chloride popular. — Carelessness of chloro- Contents. 7 Page form administration. — Utterly impossible to obtain cor- rect percentage of deaths caused by anaesthetics. — Anajs- thetic deaths exaggerated 92 LECTUKE IX. Nitrous Oxid Gas. Part played by Priestley, Sir Humphrey Davy, Wells and An- drews. — Dr. Burton Lee Thorpe settles the controversy. — Colton 's lecture. — Wells discovers anaesthetic properties of nitrous oxid. — Dr. Riggs extracts tooth for Wells. — Physical properties of nitrous oxid. — Anaesthetic action of nitrous oxid. — Claude Martin's experiments. — Apparatus for manufacturing nitrous oxid. — Nitrous oxid cylinders. — Weight of nitrous oxid gas. — Nitrous oxid appliances. — Improved cylinders, containing from 2.5 gallons to .3,200 gallons. — A. C. Clark's, and Teter's appliances illustrated 104 LECTURE X. Nitrous Oxid Gas Administration. Difficult to administer. — An assistant necessary. — Arrange- ment of patient in the chair. — Mouth-prop is important. — Average time of induction. — Care in selecting patients. — Adjustment of the inhaler. — Amount of nitrous oxid necessary. — Anajmies susceptible. — Alcoholics require more. — First stage of anaesthesia symptoms. — Second stage of anaesthesia symptoms 120 LECTURE XL Nitrous Oxid Gas Administration — Continued. Third stage of anaesthesia symptoms. — Stage of surgical anaes- thesia. — The respiration. — The circulation. — Muscular phenomena. — Fourth stage of anaesthesia symptoms. — Effects of an overdose. — Description of the action of nitrous oxid in thirteen fatalities. — Nitrous oxid warmed. — Kindly by patient. — Administration 131 LECTURE XII. Nitrous Oxid and Oxygen. Oxygen a supporter of life. — Experiments by Priestley and Demarquay. — Andrews of Cliicago, the first to use this combination. — Safest anaesthetic known. — Hillischer 's es- timate of its safety. — Apparatus. — Percentage of oxygen necessary. — Air a disadvantage. — Administration. — An unobstructed airway requisite. — The four anaesthetic stages, — Anaesthetic sign. — Nitrous-oxid and oxygen-car- bon dioxid-anaesthesia. — Experiments of Yendall Hender- son and Mosso. — Carbon dioxid not a waste product but 8 Contents, Page one of the most important harmones. — Advantages of car- bon dioxid as respiratory stimulant. — Experiments recom- mended to test its further value 143 LECTUEE XIII. Nitrous Oxid and Oxygen in Operative Dentistry. Nitrous oxid and oxygen in all painful operations on the teeth. — The Gregg nitrous-oxid inhaler. — De Ford nitrous-oxid and oxygen inhaler. — Its use in sensitive cavity prepara- tion. — Eemoval of pulps. — Shaping teeth for crowns and abutments. — Opening into teeth affected with pericement- itis and acute alveolar abscess. — All painful and fatiguing operations on the teeth. — Administration. — Suggestions to the patient. — Description of a clinical case. — The Teter's nasal inhaler illustrated 161 LECTUEE XIV. Ethyl Chloride. First used by Heyfelder. — History. — Eequisites of a perfect anaesthetic. — Safety of. — Action on the circulation. — Luke's estimate of. — Administration. — Tubes and cap- sules. — General and local ansRstheties. — Inhalers. — Action of patient under. — Neurotic women and alcoholics. — Cyanosis. — Supervening nausea. — Headache 161 LECTUEE XV. SOMNOFORM. History. — Dr. G. Eolland the discoverer. — How an ideal anaes- thetic should act. — Ethyl chloride. — ^Methyl chloride. — Old and new formula. — Induction period. — Available period of anaesthesia. — As to safety. — Stage of surgical anaesthesia induced by nitrous oxid more dangerous than stage of surgical anaesthesia induced by somnoform. — Tubes and capsules. — Nausea following use of tubes. — Stark's inhaler described. — De Ford appliances described. 179 LECTUEE XVI. SOMNOPORM — Continued. Physiological advantages. — Circulatory action. — Stimulating effect. — Earely depresses. — Eespiration in. — Holding the breath in. — A twenty-five-minute anaesthesia. — Illustra- tive cases. — Not cumulative. — No change in the amount of hajmoglobin or in the number of leukocytes.-^^Non- irritating to mucous membriuie and nerves. — Syncope of Duret. — No swelling of tongue. — Nausea rare. — Deeper anaesthesia than necessary. — Air an advantage. — Normal breathing. — Illustrative case. — Nausea cases. — Nausea Contents. 9 Page from swallowing blood. — Headache following. — Carbon dioxide 195 LECTURE XVII. SoMXOFORM Administration. Illustrated by a ease. — Easiest of all anaesthetics to adminis- ter. — Exclusion of air. — Method discouraged. — Admission of air. — In multiple extractions. — Normal breathing. — Other than month operations. — An anaemic patient. — A plethoric patient. — Stark's inhaler. — A hysterical patient. — A nervous girl. — Stark 's inhaler in nausea cases. — Stark's inhaler illustrated. — A somnoform capsule illus- trated. — A box of somnoform capsules illustrated 207 LECTURE XVIII. Somnoform Administration — Continued. Oxygen deprivation. — Excitement under. — Never restrain pa- tient. — A case in practice. — Excitement usually after in- duction. — Illustrative cases. — In an asthmatic. — A very nervous patient. — An over-ana?sthetized patient. — Anal- gesia following. — Illustrative case. — A dead pulp. — Effects of tobacco, chloral, morphine, alcohol, etc. — Patient intoxicated. — A pronounced alcoholic. — Combina- tion of alcohol and morphine. — ^Ansesthetic symptoms. — Dental uses of. — Sensitive cavity preparation. — Preparing tooth for crown. — In acute pericementitis. — In acute alveolar abscess. — For exposing and removing dental pulps.- — Evacuating pus. — Lancing gum. — Curetting and cauterizing pus pockets. — Opening into antrum. — Ampu- tating roots. — For dentigerous cysts. — Alveolar and max- illary necrosis. — Extraction of teeth. — Illustrative cases. 218 LECTURE XIX. Somnoform Analgesia. Class of cases in which indicated. — All painful conditions. — Sensitive dentine. — Septic j)ericementitis. — Acute pulpitis. Shaping teeth for crowns. — Illustrative cases. — The De- Ford Somnoform Appliance. — How to use the appliance. 2.S2 LECTURE XX. Chloroform Analgesia. Dr. Austin C. Hewett, of Chicago, first advocate. — Experi- mented upon himself. — Committee appointed to visit his office. — Report of committee. — Hlustrative cases. — Dr. Hewett 's attitude in relation to chloroform. — How ad- ministered. — At variance with all recognized authorities. — Recommendations oi the committee 24;? 10 Contents. LECTUEE XXL Ether and Chlorofosm. Page These agents should not be used by the dental surgeon to in- duce surgical anaesthesia. — Hospital recommended for all ether and chloroform eases. — Objections to their use in the office. — Chloroform deaths in the dental chair. — Advan- tages of a surgical chair. — Anaesthetist and nurse. — Ether safer than chloroform. — Dentist should know physiological action of ether and chloroform. — Should know how to ad- minister these agents. — History and physical properties of ether. — Close and open methods of administration. — Luke's estimate of American anaesthetists and anaesthesia. — Protection of eyes and face. — History and physical properties of chloroform. — Chloroform tests. — Preparation of the patient. — Chloroform administration. — Hewitt's table showing anaesthetic stages 257 LECTURE XXII. Difficulties and Dangers Incident to Administer- ing General Anesthetics in Dental Practice, and How to Meet Them. Allay fear. — Remove the corset. — Handling children. — Mental and physical excitement. — Case of a cigarette fiend. — Dan- gers that may arise. — Respiratory arrest. — Mechanical and paralytic. — Toxic, mechanical, and reflex causes. — Mechanical causes and treatment 279 LECTURE XXIIL Difficulties and Dangers Incident to Administer- ing General Anesthetics in Dental Practice, AND How TO Meet Them. — Continued. Presence of foreign matter in the throat. — Blood, mucus, vomit, roots and teeth in the throat. — Cases reported of foreign matter in the throat. — Respiratory arrest the result of paralysis of the respiratory center. — Artificial respiration. — Sylvester's method. — Marshall Hall's method. — Drugs not of much avail. — Circulatory failure. — Treatment of circulatory failure. — Horizontal 'position. — Heart massage. — Tongue traction. — Wet towels. — Am- monia nitrate, amyl nitrite, strychnia, adrenalin, caffine. — Equipment recommended ..,.,,.,.,.,.. 293 -" gns l)eforo entoring; tlie air passages. The anaesthetist hohls tiie mask to the face, sets the oxygen and nitrous oxid per- centage vahes for wliatever mixture of these gases lie desires, determines the volume of tidal respiration and sets the adjust;ible rebreathing bag for whatever jjortion he wants the patient to rebreathe, if any. He tlsen watches his i)atient for the sj-mptoms which will indicate whether the mixture is correct or not and makes such corrections as are necessarj'. A beginner who is familiar M'ith the properties of this anaesthetic and who is thor- oughly acquainted with other antesthetics, will often give a buc- cessful gas-oxygen ansestb^sia of an hour for ma^or surgerj^ on til? first trial, 114 General Anesthetics in Dentistry. AN X-EAY VIEW OF THE M'KESSON APPARATUS PROPEE, SHOWING THE CONSTRUCTION IN DETAIL. 1. Automatic self-filling bags. 2. Square gas channels with valves which actually represent the percentage of each gas used. 3. Both NoO and O check valves are mounted on the same shaft so that the oxygen valve cannot ' ' stick, ' ' but opens with each inhalation, resulting in a smooth anassthesia. 4. A separate, adjustable, graduated bag for rebreathing, which measures the tidal respiration in cubic centimeters (a source of valuable information) and permits of instantaneous adjustment for any amount of rebreathing to be performed auto- matically and uniformly. If desired the gas from the "Bronchia tree" only, amounting to 140 c. c, which contains no CO2, may be stored at each exhalation, to be rebreathed at the next inhala- tion, thus saving 73 gallons of gas per hour and in no way inter- fering with anaesthesia or the safety of the patient. 5. Moving parts are always yiaibli? through the plate glass; General Anccstlietics in Dentistry. 115 ders are now being made that contain as small an amount as twenty-five gallons to those that contain as much as thirty-two gallons of nitrous oxid. As nitrous oxid gas does not deteriorate with age, the larger cylinders are more convenient for dentists re- mote from a dental depot who have to pay transporta- tion charges. One feels far more comfortable with the larger cylinders when administering nitrous oxid for a prolonged surgical anaesthesia, and even in dental prac- tice it is assuring to feel that there is sufficient gas for the operation without the annoyance of changing cylinders. Taking into consideration the transporta- 6. A very light face piece with an expiratory valve so guarded that the inhaled breath cannot be blown toward the operative field. 7. A practical ether cup, which may be used in a variety of ways: (A) For the administration of ether in conjunction with NjO and O, thus securing relaxation in the most refractory patient. (B) For the administration of ether with air and pure oxygen. (C) For the administration of ether with rebreathing and other combinations. 8. Compactness. The apparatus may be carried in its case and sufficient gas in the other case for a three to four-hour administration at the patient's home. Eebreathing should be done not primarily to save gas, but to prevent "over-ventilation" of the blood frv)m rapid respiration, which is a factor in the causation of shock. The patient ordinarily should not take more fresh gas than he would breathe of air, normally (7,000 to 8,000 c. c. per minute). If he breathes 30 times per minute of 500 c. c. or 1,500 c. c. per minute, the rebreathing bag should be set for one-half that volume or 250 c. c, so that at each inhalation he will rebreathe 250 c. c. of the previous exhalation and but 250 c. c. of fresh gases, thus restoring the normal ventilation of the blood and preventing excessive loss of COo, and the tendency to develop shock. With a ventilation below 8,000 c. c. rebroattiing should not be i)orniitted. With this apparatus the only anaesthetic which approaches absolute safety may be easily, smoothly and scientifically admin- istered for any operation. With a nasal inhaler, the dentist or [jhysician may obtain a state of analgesia for prolonged periods without assistance while intra oral or other work is being done. Or a profound anapsthesia for removal of teeth, tonsils, adenoids, ^tc, may be continued as long as necessary, 116 General Ancvsthetics in Dentistry. tion charges and the loss in each cylinder when the gas does not come out even, the larger C3dinders are far more economical than the smaller. In the earlier manufacture of cylinders, annoyance and inconvenience was caused from imperfect valves- THE OHIO :\IONOVALVE. For the administration of nitrous oxid and oxygen. Chloro- form and ether can also be used with this appliance in combina- tion with nitrous oxid and oxygen. A device for warming these gases can be easily attached. This appliance, as shown in the cut, is equipped with 100-gallon nitrous oxid cylinders and 40-gallon oxygen cylinders. It can be connected up with the larger cylin- ders containing as much as 3,200 gallons of nitrous oxid and the amount of oxygen corresponding. The appliance is manipulate^ by the operation of a single valve. General Aiiccsthetics in Dentistry. 117 These valves would permit the gas to escape and sometimes only one or two administrations of nitrous oxid could be made from a one hundred-gallon cylin- der. It is embarrassing, when you only need two or three more inhalations to complete an anaesthesia, to NO. 1 POETABLE STAND, WITH STYLE F CYLINDERS. Cylinders hold 350 fi;allons oxygon and 1,280 gallons nitrous oxid. Stand can be omitted and wall clamps supplied when desired. The regulators automatically reduce the gas pressure, caus- ing an even flow which can be perfectly controlled. These cylinders are manufactured by the Ohio Chemical Com- pany and used with their Ohio Monovalve Appliance, 118 General Ancesthetics in Dentistry. find the cylinder exhausted, which is supposed to be two-thirds fulL Four gallons of nitrous oxid weigh one ounce. It requires five and one-third gallons of oxygen to weigh an ounce. One hundred gallons of nitrous oxid should weigh just about 25 ounces. Each cylinder has marked on it or on a tag attached to it the weight of the cylinder and the weight of the gas. It is a good plan to weigh the cylinder when you unbox it and ascertain if there has been a leakage and about how much. WARMING DEVICE, INCLUDING ETHER OR CHLOROFORM ATTACHMENT FOR OHIO MONOVALVE. Gas passes tlirough a radiator in a receptacle filled with water. The water is heated by electricity and temperature controlled by a rheostat. In the absence of electricity the hot water can be renewed during long operations. Ether or chloroform are regu- lated to drop as frequently as desired on a |^ot surfacgj causing perfect expansion of the liquid tO gas, General Anesthetics in Dentistry. 119 If an administration has not been made for some time and you are in doubt as to the amount of nitrous oxid that should be in the cylinder, it is better to weigh the cylinder than take the risk of having the gas a little short of enough to induce the desired anaesthesia. Just recently the manufacturers have equipped their large cylinders with pressure regulators, enabling one to tell the number of gallons of these gases that remain in the cylinders at any time. The more modern appliances are provided with two cr four cylinders, so arranged that you can switch from an empty to a full cylinder ; but even this involves a loss of time and division of attention when the oper- ator should not be interrupted. The matter of appliances is an important one. There are many from which to select, each having its advantages. The addition of oxygen to nitrous oxid for the pur- pose of prolonging anaesthesia has resulted in a modifi- cation of the older appliances to adjust themselves to the new condition. Nitrous oxid without the addition of oxygen can be used in all the appliances to which I shall call attention or describe. 130 General Ancrsthetics in Dentistry. LECTURE X. Nitrous Oxid Administration. For the sake of convenience, we will discuss this subject in the following order: First: Nitrous oxid pure, without air. Second : Nitrous oxid with an admixture of air. Third : Nitrous oxid and oxygen. There is only one anaesthetic more difficult to ad- minister than nitrous oxid ; namely, nitrous oxid and oxygen. Too much apparatus is necessary in the ad- ministration of nitrous oxid to make it popular, and, for this reason it will never be universally adopted by dentists as ether and chloroform have been by physi- cians. When the physician operates, he simply oper- ates and has no care of either the patient or the anaes- thetic ; but when the dentist has occasion to administer nitrous oxid he usually performs a three-fold service; namely, plays the role of anaesthetist, assumes the care of the patient, and, in addition to these, performs the operation. In other words, he assumes the duties of anaesthetist, nurse and surgeon. No surgeon would undertake to administer his own anaesthetic, care for the patient and jjerform an operation, except in the extremest emergency ;' yet the dentist assumes such a responsibility, and when failures result blames nitrous General Anccstlietics in Dentistry. 121 oxid, never for a moment taking into consideration that he has attempted to accomplish too much. It would be a simple matter to administer ether and extract a number of teeth without an assistant, as com- pared to administering nitrous oxid alone and extract- ing a number of teeth. With ether you could anaesthe- tize the patient sufficiently deep to complete the opera- tion before beginning to operate ; while, with pure ni- trous oxid, you have only about ninety seconds in which to anaesthetize and operate, and there is too much for any man to do in so brief a time. Nitrous oxid in itself is an excellent anaesthetic; it can do all that has been claimed for it, and those who have failed to successfully administer this anaesthetic are at fault, and not the anaesthetic. This is why in a previous lecture 1 laid so much stress on the import- ance of a well-trained assistant. Indeed, some of our most successful extracting specialists extract only, the assistant assuming the entire anaesthetic responsibility. Let us assume, then, in all that I shall say in regard to administering nitrous oxid gas, whether in the pure state or in combination with admixtures of air or oxy- gen, that a good assistant is as essential to success as an appropriate appliance, as a good anaesthetist or as a skilful extractor. If ^•ou have not read the lecture- on "I^lemenls on Success," in regard to tlie i)rui)cr preparation of the patient, both mentally and physically, preliminary to administering an anresthotic, I recommend that you do so before perusing this lecture. The patient having been made ready, as previously 122 General Anesthetics in Dentistry. explained, with a good assistant at the left of the chair, the patient properly and comfortably arranged in the chair, only the mouth-prop is lacking; that adjusted, we are ready to consider the administration of nitrous oxid. Never administer nitrous oxid without first insert- ing a mouth-prop. Insert the mouth-prop the last thing before adjusting the inhaler. It is never safe to ad- minister nitrous oxid without a mouth-prop, and I con- sider one criminally negligent to do so. There are a number of reasons why a mouth-prop shoidd be used ; the one we are interested in just now is to hold the jaws apart in order to facilitate speedy operating. Many dental surgeons fail just here. Under nitrous oxid anaesthesia, the masticatory muscles usually con- tract, sometimes violently. Having satisfied yourself upon removing the inhaler that the patient is suffi- ciently anaesthetized to begin operating, if a prop has not been used, the mouth will be found closed, and sometimes the teeth forcibly held together, and so much time is consumed in opening the mouth, if it can be opened at all, that the tooth is fractured in the hurry, or the wrong tooth extracted, or the patient is hurt, or awakes and nothing has been accomplished. Hewitt gives the average induction period of nitrous oxid gas without air as fifty-six seconds, and the aver- age available anaesthesia about thirty seconds, so there is no time for forcing the mouth open, and it is highly important that the month-prop l)e not neglected. Let me say just here, make it a rule never to hurt your patient. The object in taking nitrous oxid gas General Aiucsthetics in Dentistry. 123 is to avoid the pain of the operation. If you lose too much time in getting started, you better not operate at all than to have the patient hurt. The patient will complain to all his neighbors that he knew everything that was done, and was never so badly hurt in his life, and advise everybody he meets for weeks against taking nitrous oxid. Exercise the greatest of care, in the beginning, in the selection of suitable subjects. The operation itself should be of the simplest nature. Some one may present with one easy tooth to ex- tract, or two or three loose pyorrhoea teeth. With such a case, there is no anxiety about the operation, but your entire attention can be given to administering the anaesthetic, studying the patient and learning an- aesthetic symptoms. It is unreasonable on your part to expect to obtain perfect results from the very first administration, and to start in as an accomplished anaesthetist. You do not expect to do this in other de- partments of dentistry when you take up something new with which you are not familiar. It is an excellent plan to reserve the anaesthetic for such cases forty, fifty, sixty times or more, gaining confidence each time, and later undertake more difficult cases. If a patient presents "with a mouthful of teeth" to be extracted, make no promise in advance as to the number you will remove under one administration of nitrous oxid gas. If you should promise ten and suc- ceed in extracting but three, you make a sad failure. Say this: "I will extract as many as I possibly can, and will not hurt you," and be sure to cease extracting be- fore they feel pain. You might say that "much de- 124 General Anesthetics in Dentistry. pends upon the breathing," as explained, and that "some patients are more deeply anaesthetized than others." If you succeed in removing three or four teeth, you are safe ; if you should succeed in extracting eight or ten teeth, your reputation is made with that patient. Whatever the number, be sure to stop before the patient feels pain. Better not extract at all if from nervousness the patient does not take the anaesthetic well ; but have him return another day. It will con- demn any anaesthetic to operate too soon or too long and the patient feel the pain. In regard to extracting under nitrous oxid, let me say it is a very different proposition from extracting without an anaesthetic. It is something that has to be learned, no matter how skilful an extractor you may be. Without an anaesthetic, the patient keeps his tongue out of the way, and, in a degree, the cheeks, and the mouth opens wider if you wish it, and the head turns to one side or the other on command; but, under nitrous oxid gas, you must be careful not to wound the tongue or cheeks, must accommodate yourself to the space obtained by the mouth-prop, and operate speedily. To return again to the administration of nitrous oxid gas, measures must be taken to exclude all air. Adjust the inhaler to the face and satisfy yourself that it fits accurately. The pneumatic cushion or rim should not be blown up too tightly, but about half full of air ; then it can more accurately be made to conform to the features than when more tense or rigid. If the patient wears a heavy mustache or beard, especially the beard, General Anccsthctics in Dentistry. 125 it is an excellent plan to dampen some surgeon's gauze and place three or four layers around the rim, then press this tightly against the beard with the inhaler. Have the assistant release the gas and allow it to pass into the rubber bag until it is almost full. Shut off the gas for a moment, open the exit valve and the gas in the bag will force out of the tube running from the bag to the inhaler the air it contains. It is very important that the valves should work accurately and sensitively. Adjust the face-piece carefully this time and see that no air can gain admittance under the pneumatic rim, the valves having been tested previously to ascertain if they are in perfect working order. Instruct the pa- tient to breathe deeply and regularly. I prefer in the beginning that they take three or four inhalations of air through the inhaler, the gas being shut off; then gradually admit the nitrous oxid gas. From this time on, exclude all air. The assistant should now keep the gas bag nearly full, and, when the patient is sufficient- ly anaesthetized, be sure to turn off tightly at the cylinder. Judging from my own experience, eight gallons is the average amount of nitrous oxid gas necessary to in- duce anaesthesia, when all air is excluded; Hewitt says six. In some cases, I have found two or three gallons sufficient ; in others, fifteen or twenty gallons. Frail patients, children and an^emics are very susceptible to nitrous oxid gas ; the plethoric and alcoholics require a greater amount. The condition of the patient, of course, is the test in all cases ; nevertheless it was very satisfying under the gasometer plan when it was 126 General Ancesthetics in Dentistry. possible to see the indicator and note the number of gallons that were being inhaled. The induction period of nitrous oxid gas is so brief and the phenomena occur in such rapidity, that I have not been able to make a satisfactory classification of symptoms. The four anaesthetic stages are easily dis- cernible under alcohol, ether and chloroform ; but the action is so quick under pure nitrous oxid gas, ethyl chloride and somnoform, that I have not been able to differentiate them. Hewitt has more thoroughly in- vestigated and experimented with nitrous oxid gas than any other writer, and he also speaks of the diffi- culty of classifying nitrous oxid gas phenomena into four groups; yet his intimate knowledge of the subject has enabled him to accomplish this, and we will fol- low his outline. First Stage. Patients vary greatly in the matter of symptoms experienced during the inhalation of nitrous oxid gas. This is to be expected, because an anaesthetic does not destroy one's personality. No two patients probably have an identical experience. This is true in the more common things of life. I have been frequently annoyed at the theater by those about me laughing audibly when to me the grouping was pa- thetic, and at other times situations that appealed to me as humorous, brought no smile to the countenance of my neighbors. If you had an opportunity to treat five men to a large drink of whisky, just as they hap- pened to be in a group, and kept them together long enough to study the effect, they would not react alike to this stimulant. One man would probably become General Anccsthetics in Dentistry. 127 talkative, another feel like singing, another become drowsy, another no effect at all, according to their in- dividual temperament. Even in the condition we call sleep, which is purely physiological, individuals vary widely. Some sleep lightly and are easily disturbed, while others sleep profoundly and nothing disturbs them. Some experience the wildest kind of dreams, horrible to relate ; others in their dreams have visions sublime. Just as the harrowing incidents of the day disturl) the mind to the degree of sleeplessness, so in a disturbed mental state patients do not sleep quietly and tranquilly under an anaesthetic. This condition and how to overcome it is discussed in the lecture on "Elements of Success." When nitrous oxid is adminstered properly, the pa- tient having been made ready mentally and physically, the sensations experienced are more likely to be of an agreeable than of a disagreeable character. This is characteristic of nitrous oxid when inhaled experi- mentally, and, if it is not so when an operation is to be performed, it shows that the disturbed mentality inci- dent to the operation is the disturbing element rather than the nitrous oxid gas. Should tile apparatus possess valves which do not work easily, or should the channels through which the gas is made to pass be too small, or "should the patient through the want of confidence or knowledge breathe in a shallow or restricted manner, or through the nose, an unpleasant experience may result. Hewitt insists on mouth breathing when pure nitrous oxid gas is be- ing administered. I never instruct patients in regard 128 General Ancesthetics in Dentistry. to this point, lest they become confused, but in the deep breathing required, when the mouth is held open by a prop, think there is a combination of both nasal and mouth inhalation and that the latter predominates. An "indescribable pleasant numbness all over the body and a feeling of warmth in the lips" are amongst the first sensations experienced. Following these is a peculiar pleasurable "thrilling" which hardly admits of description. Then follows, with some, a ringing in the ears, tinnitus, and a fulness in the head, caused by in- creased circulation of the blood. It is at this stage that those who are aiTected unpleasantly begin to hear and see things, and the quicker over, the better. The loss of consciousness comes on now before the patient has time to define his feelings. The pulse grows fuller under the finger ; and its caliber is somewhat increased at this stage. The power of hearing still persists and noises or conversation have a tendency to excite the pa- tient. In my early anaesthetic practice I used a small music box and it was just at this stage that the assist- ant was signalled to touch it off. The average time of this first stage, from the commencement of the inhala- tion of nitrous oxid gas till the loss of consciousness, is about thirty seconds. Second Stage. With the loss of normal conscious- ness disturbed physical states arise. As a rule, the patient gives little or no evidence of such disturbance, more especially if allowed to remain perfectly quiet. If roughly handled, the patient is liable to become ex- cited and move his hands and legs. Any injury inflicted during this stage may produce immediate reflex effects, General Anccsthctics in Dentistry. 129 such as shouting, co-ordinate or inco-ordinate move- ments, but it would not be accurately remembered by the patient. This stage is often mistaken by dental surgeons for the anaesthetic stage and they begin to operate, and sometimes have disastrous results. The patient yells, screams, struggles, and if strong enough breaks away; frees himself if possible, and there are instances on record where the anaesthetist has suffered physical violence. Other operators at this stage, if the patient becomes a little nervous — attempts to move or struggle — imagine that this is one of the cases in which the patient does not take nitrous oxid well, "he is probably as deep as I can get him, I had better extract quickly," and he does and is apt to have a fight on his hands. A few more inhalations just at this time would have induced surgical anaesthesia. Nitrous oxid is often accused of producing imper- fect anaesthesia, because operations are sometimes com- raienced at this stage. Many nitrous oxid gas appli- ances have been relegated to the garret or laboratory on account of the chagrin felt by the dentist after an experience of this kind when neither the appliance nor the anaesthetic was at fault, the operator simply mis- taking the second stage for the surgical stage. Dreams are common, but are rarely distinctly re- membered. These depend largely on the mental state of the patient at the time of losing consciousness, and sometimes on the kind of dreams experienced during natural slecj). I recall a patient who had apparently a horrible dream. She made the most hideous of noises, and seemed to be suffering: the torments of the damned. 130 General Anaesthetics in Dentistry. After she returned to consciousness, the friend who ac- companied her told me the patient frequently had just such "nightmares" in her sleep at home. Fortunately the dreams that occur under nitrous oxid gas anaes- thesia are usually of a pleasing rather than of a dis- agreeable nature. Hewitt maintains that it is a curious fact that unpleasant dreams are more common under nitrous oxid gas per se than under nitrous oxid gas and oxygen, probably because the anaesthesia in the latter case is deeper, so that operations or other interferences, which in the case of nitrous oxid gas itself might leave some disturbed impressions, are not capable of doing so when the anaesthesia is more profound. In this stage respiration is still quicker and deeper than normal, and, save perhaps for an occa- sional swallowing, is perfectly regular. The pulse is still full and a trifle quicker than in the first stage. In some cases, a spurious form of stupor may occur and it is to be disregarded. The conjunctiva is sensi- tive to touch. The pupils usually grow larger as the administration proceeds. The eyelids are usually af- fected by a slight twitching; and, as the inhalation proceeds, they have a tendency to separate and to dis- play the subjacent globes. As the lids separate and the eyeballs become more prominent and fixed, the features lose their normal color, and become dusky, then livid. Blonds are more susceptible to duskiness and lividity of features than brunettes. Sallow people show very little change of color. At the close of this second stage, the respiration is deeper and fuller and the pulse stronger than at any previous time and the patient is in the best possible condition. General Anaesthetics in Dentistry. 131 LECTURE XL Nitrous Oxid Gas Administration — Continued. Third Stage. The first indication that the patient is passing or has passed into the third stage of anaesthesia is usually afforded by the respiration. The breathing, which hitherto preserved its rhythm, now loses it, and a peculiar characteristic throat sound, sometimes de- scribed as "stertor," becomes audible. This sound is most probably due to irregular spasmodic elevations of the larynx towards the epiglottis and base of the tongue, and indicates the tendency to obstruction in the air-way at this point. It occasionally happens that the respiration becomes somewhat feeble ; or expiration becomes somewhat prolonged and rather strained. These phenomena should, in the presence of other signs of anaesthesia, be taken to mean that the administra- tion has been pushed far enough. Now is the proper time to begin to operate. To wait longer is to invite danger. The heart is still beating strong, and the pulse is very full and rapid. As to how much of an opera- tion may be attempted depends largely upmi the opera- tor and also upon the patient. You can learn this only by experience. Some operators are more expert than others, some are quicker than others and have more confidence in themselves. Some dental surgeons seem 132 General Anaesthetics in Dentistry. to know by intuition when to cease operating; others never seem to know the limitations of pure nitrous oxid gas antesthesia. Some patients are more pro- foundly anaesthetized by the inhalation of, say, eight gallons of nitrous oxid gas than others, and the period of operating will be two or three times as long. With some patients, there is hardly enough time to make one difficult extraction, while others as many as eigh- teen or twenty teeth may be removed. Remember that the average available anaesthesia inducted by pure nitrous oxid gas is only thirty seconds. A pulse that was one hundred and twenty immedi- ately before the administration may, for example, rise to one hundred and sixty or more ; whereas a pulse of eighty or ninety at the beginning of the inhalation will not exceed one hundred or one hundred and ten in the third stage. Immediately that air is admitted by the withdrawal of the anaesthetic, the pulse abruptly un- dergoes a marked change. It at once becomes slower and fuller. A pulse at one hundred and forty at the acme of anaesthesia may suddenly drop to about eighty per minute before the effects of the anaesthesia have passed off. Various muscular phenomena may appear. When respiration undergoes the changes referred to, the arm, if raised, will generally fall. But there is a tendency for clonic muscular contractions to occur in all cases, and for tonic spasm to arise in many. In some cases, the facial muscles are chiefly affected by the convulsive seizure; in others, the whole body mildly oscillates, the spasm apparently chiefly affecting the trunk muscles; General Ancrsthctics in Dentistry. 133 in others, the hands, legs, and arms alone may twitch ; whilst, in a fourth group of cases, the neck may be affected by barely perceptible clonic spasm, so that the head is felt to move with fine rhythmic jerks in one or other directions. Dr. Buxton found that one-third of the men and nearly one-third of the women anaesthetized by him at the Dental Hospital displayed ankleclonus under nitrous oxid. Micturition rarely occurs, but it is sometimes met with in children. Defecation is extremely uncommon. The pupils in a majority of the cases are dilated in deep nitrous oxid gas anaesthesia. In some cases, however, they remain a moderate size or may be con- tracted. The conjunctival reflex, which will have per- sisted during most of the administration, becomes less marked or disappears. It can not be depended upon as a guide. The corneal reflex usually persists. Fourth Stage. If all air has been excluded and the patient is still inhaling pure nitrous oxid gas, there is danger now of an overdose, which constitutes the fourth stage of anaesthesia. Hewitt has said that dan- gerous asphyxia will occur in fifty-six seconds (average time) if all air is excluded, and he also states that the average time required to induce surgical anaesthesia is fifty-six seconds. There is then no working margin, and the anaesthetist should be extremely careful at this stage of induction. As careful as we may be, how- ever, to exclude air it is probable that some air has been admitted to the lungs. Always be guided by anaes- thetic symptoms — no one should think of gauging the 134 General Ancesthetics in Dentistry. time at which to operate merely by the watch. A gentleman from Australia gave an anaesthetic clinic at the Jamestown Exposition Dental Meeting. He would administer the anaesthetic for twenty-two seconds each time by the watch and proceed to operate regardless of the condition of his patient. If an overdose of nitrous oxid gas is administered, the breathing becomes embarrassed and then ceases, either, as Hewitt, says, as the result of muscular spasm or by the more commonly accepted cause, paralysis of the respiration. The more vigorous the patient, the more powerful will be the spasm. At the time the breathing ceases, the color of the face is a deep purple, sometimes even black, pupils usually dilated, the eye- lids widely separated, and the cornea prominent and fixed. In strong and vigorous patients, the heart some- times continues for a period of several minutes, and, at the time that respiration ceases, it is not always de- pressed. On the other hand, in debilitated patients with weak or fatty hearts, delayed respiration will more speedily be followed by cardiac arrest. There seems to be no case on record in which death has re- sulted from primary circulatory arrest, following the administration of nitrous oxid gas. As pointed out in previous lectures, it is all import- ant to observe the respiration, for as long as the res- piration is properly performed, the heart will take care of itself. It 1>eh()oves the dental anaesthetist to know respiration thoroughly, and he should familiarize him- self with the anatomy of the respiratory tract, especial- General AtucstJictics in Dentistry. 135 ly the nerves that supply and control the respiratory muscles. Swollen and enlarged tongue is common to pure nitrous oxid gas anaesthesia. This condition is depend- ent upon the engorj^cment of the blood vessels of the tongue. If the tongue becomes thus engorged, it is probable that the blood vessels along the entire respira- tory tract are also congested. It becomes important to satisfy ourselves whether the patient has nasal sten- osis, pharyngeal adenoids, enlarged tonsils, oedema of the uvulva, morbid growths of the soft palate, larynx or trachea, or any other condition that may impede or make more labored the respiration. When patients do not take nitrous oxid gas well and become unduly ex- cited or cyonotic too soon, the condition probably arises from some respiratory obstruction, rather than from nitrous oxid gas, per se. Hewitt made a careful search of the dental and medical journals for records of nitrous oxid gas deaths from 1860-1900, and found but thirty recorded. He has placed these in appropriate groups and they make a most interesting and profitable study. Class A he des- ignates deaths undoubtedly due, partly or wholly, to nitrous oxid gas. Case 1. l-emale, 38; stout; enlarged tonsils and uvulva; dental operation; double administration; as- phyxia. Case 2. Male, middle-aged; obese; dental opera- tion ; double administration ; asphyxia. Case 3. Male, 57 ; tongue enlarged by morbid 136 General Anccsthetics in Dentistry. growth and fixed ; dental operation ; convulsive tremor and rigidity ; asphyxial syncope. Case 4. Male, about 50 ; dental operation ; syn- cope. Case 5. Female, 7\ ; stout ; corsets tight ; food in stomach ; dental operation ; probably asphyxia. Case 6. Male, 24; dental operation, syncope. Case 7. Female, dental operation ; mode of death uncertain. Case 8. Male, 39; small and deformed lower jaw; dental operation ; asphyxia. Case 9. Female, dental operation ; asphyxia prob- ably favored by morbid state of upper air-passages. Case 10. Male, 26; enlarged tonsils; receding lower jaw; short neck; dental operation; asphyxia. Case 11. Female, 23; tight corsets; full stomach; dental operation ; asphyxia. Case 12. Female, 22 ; dental operation. Case 13. Male ; dental operation ; asphyxia. Case 14. Male, 12; large abscess in base of tongue; fixed lower jaw; opening abscess; asphyxia. Case 15. Male, 7; very delicate; old standing peri- carditis and pleurisy ; dorsal posture ; operation for adenoids ; nitrous oxid given with air ; syncope ; no obstruction in breathing. Case 16. Female, 27 ; food in stomach ; double ad- ministration ; vomiting ; dusky pallor ; syncope ; opera- tion on elbow. Case 17. Male, 36; suppuration of neck; left tonsil swollen; incision of neck; nitrous oxid with air first given ; then pure nitrous oxid ; cessation of respiration ; General AnccstJietics in Dentistry. 137 death from asphyxia ; at necropsy, larynx found to be odematous. In 13 deaths out of a total of 17 deaths, the opera- tion was classified as dental. And it would seem that in nearly all of these deaths some pre-existing condi- tions were present to which these deaths might be at- tributed. In Case 1, enlarged tonsils and uvulva and a double administration. Case 2, patient "obese" and double administration. Case 3, tongue enlarged by morbid growth. Case 5, corsets tight and food in stomach. Case 7, double administration. Case 8, small and deformed lower jaw. Case 10, enlarged tonsils. Case 11, tight corsets and full stomach. Out of the thirteen dental cases, there were three double administrations, two with tight corsets, and two with full stomachs. Nitrous oxid anaesthesia is so quickly induced and is of such brief duration that unpleasant after-efifects are generally avoided. Once in a while, a patient with a very delicate stomach, one that is subject to car sickness or that strong odors of any kind afifect un- pleasantly, may become nauseated. Weakness and ex- haustion rarely follow. Plethoric or full-blooded i)eo- ple, if they are subject to attacks of headache, may suf- fer a few hours from cephalgia. Patients more frc- quentl}^ leave the office stimulated and buoyant than depressed and morose. Nitrous oxid, in my estimation, is not an ideal den- tal anaesthetic. It is entirely too brief in its action to be universally successful. As patients come to me to be anaesthetized from other operators, more condemn 138 General Aiuvstlictics in Dentistry. nitrous oxid than praise it. Occasionally some one will say, "My experience with nitrous oxid was pleasant, the operation a success, and I would even go to Chi- cago rather than have a tooth extracted without it." For every expression of this kind I hear ten who de- clare with them nitrous oxid was a failure. Not only was the pain inflicted severe, but it was accompanied with a hideous nightmare. Those dental surgeons who are successful in administering nitrous oxid will think that I have overstated the case, but the hundreds of dentists who have discarded their gasometers and have, some of them, two or three kinds of nitrous oxid appliances hid away in closets and laboratories will say that I have understated rather than overdrawn the situation. Thirty seconds of available anaesthesia are not suffi- cient for dental purposes. It is entirely too brief for the average dental surgeon and it is the average den- tist that must be satisfied. Even our most skilled den- tal anaesthetists and our expert extracting specialists are many times defeated in accomplishing a certain operation on account of the brevity of pure nitrous oxid anaesthesia. Its greatest advantage is its safet}-. It is safe only because the patient's behavior and appearance are such that the dental surgeon has not the courage to push the anaesthetic even to the proper stage for operating, and makes a sad failure. The bulging eyeballs, the dusk}^ complexion, the stertorous breathing, the con- tortion of the face muscles and the distressed appear- ance of the patient frightens the dentist into operating General Aiicrsthetics in Dentistry. 139 too soon, but no doubt saves the life of the patient in many cases. Hewitt has said it is a dangerous procedure to ex- clude air for more than fifty-six seconds when pure nitrous oxid is being inhaled, and he also says that the average time required to induce surgical anaesthesia with nitrous oxid, with all air excluded, is fifty-six seconds, so it is evident that according to the acknowl- edged nitrous oxid authority, the point of surgical an- aesthesia and the danger point are the same. The dental surgeon in nearly all cases makes a fail- ure of nitrous oxid ; the extracting specialist through long training and frequent daily use knows the possi- bilities and limitations of pure nitrous oxid. But there is only about one extracting specialist to each thousand dentists. Pure nitrous oxid as an anaesthetic has had its day. Only in the most simple cases of extracting should it be used, if at all. Indeed, there is no longer a necessity for employing this anesthetic agent. It has been demonstrated that by adding definite proportions of oxygen to nitrous oxid, instead of an available anaesthesia of thirty seconds, an indefinite anaesthesia can be maintained. Not only can prolonged anaesthesia be maintained, but a safe anaesthesia. Anaesthesia is now possible without cyanosis, without jactitation, without ap- proaching the danger line, as very few deaths have ever been reported as arising from nitrous oxid and oxygen anaesthesia. Before discussing nitrous oxid and oxygen, which 140 General Ancvsthetics in Dentistry. naturally should be considered now, I wish to call your attention to Nitrous Oxid Warmed. I have learned that nitrous oxid warmed is superior to nitrous oxid cold as an anaesthetic. An appliance formerly used by me when teeth were to be extracted or for surgical operations had a thermometer in the "mixing-chamber," and I knew the temperature when nitrous oxid left that chamber if not when it entered the lungs. Although I knew that nitrous oxid as it passed out of the rubber bag was cold, I did not realize till I made the test for myself that the cold was so in- tense as it passed into the lungs. For an ordinary case of extracting in which eight or nine gallons of the gas is consumed the thermometer falls to 20° F. — or twelve degrees below the freezing-point. In prolonged cases I have seen the thermometer settle to 10° F. The gas passes first into the rubber bag, then into the "mixing- chamber," containing the thermometer, and from there through the tubing to the inhaler and the nose. How much the temperature of gas is raised passing through four feet of tubing, the nares and pharynx, rapidly in- haled, I do not know. But I do know that the mucous membrane over which the gas passes so rapidly be- comes chilled, and that we are not warranted in turn- ing such a cold draft into the bronchi and lungs. In a conversation recently with one of our leading phy- sicians I was advocating the use of nitrous oxid pre- liminary to ether and chloroform. He remarked, "That was my custom for years, but it was productive of so General Ancrsthetics in Dentistry. 141 much bronchial and lung trouble on account of the irri- tating properties of the gas that I abandoned its use." "Why, man," I said, "nitrous oxid is not irritating." He insisted that it was. Then I asked him if he knew the temperature of nitrous oxid as it left the bag to enter the lungs ; he said "no." I informed him — a blank look came over his face. In a moment he said, "It was the extreme cold, then, that caused my cases of bronchitis and pneumonia, was it not?" I know if I remove my collar and the mildest kind of a draft strikes the back of my neck, I have a cold and a stifif neck next day. If the outside of the neck is so sensi- tive to thermal changes, I should think the inside would become involved if I breathed deeply and rapid- ly a gas which entered my nose at a temperature of 10°- 20° — below freezing-point. With the gas warmed, the patient passes into as quiet and as beautiful an anaesthesia as we obtain with somnoform. No jactitation, seldom yelling, scream- ing and laughing so common with the usual method, and by admitting a small quantity of oxygen, no dis- coloration or asphyxia. I have administered nitrous oxid cold, thirty-three years and nitrous oxid warm fourteen years, and I have not the language at my command to tell you how pleased I am with warm nitrous oxid. Specialists who limit their practice to extracting teeth under nitrous oxid anaesthesia, who manufacture their own nitrous oxid, maintain it at the same tem- perature as the atmosphere of the operating-room, and this is one reason why they get so much better results 142 General Ancrsthetics in Dentistry. than the man who relies on the ordinary gas cylinder for his supply of nitrous oxid. I may be mistaken, but it is my belief that much of the struggling, the jactitation, the wild dreams and horrible nightmares experienced so frequently during nitrous oxid anaesthesia are caused by the cold nitrous oxid stimulating the nerves of the bronchi and lungs and they in turn reflexly communicating with the cen- tral nervous system. However this may be, I do know that with the method I am now using of warming the gas the anaesthesia resulting is quiet and peaceful and free from dreams or visions of an annoying character. Most of the new anaesthetic appliances have a warming device through which the nitrous oxid passes, raising the temperature to about 85-90° F. If all anaes- thetics were inhaled at a temperature equal to that of the body the anaesthetic agent would be more quickly assimilated by the blood and more easily eliminated from the system and would do much to maintain a normal body temperature throughout the period of an- aesthesia. General Anwstlietics in Dentistry. 143 LECTURE XII. Nitrous Oxid and Oxygen. Oxygen is a supporter of life, but nitrous oxid gas is not. Priestly, who discovered both nitrous oxid and oxygen, reported some very interesting experiments. He placed small animals under two receivers, one filled with oxygen and the other air. Those under the re- ceiver filled with oxygen lived twice as long as those under the receiver filled with the air. The death of birds in the receiver filled with oxygen transpired with- out convulsions while the death of the birds in the re- ceiver containing air was always accompanied by con- vulsions. The heart retains its irritability for hours when death takes place in oxygen, but this is not the case when death takes place in air. [Gwathmey.] "Demarquay immersed two kittens in water and kept them there until they had lost consciousness and were completely asphyxiated. One had been previ- ously confined for twenty minutes in a glass case con- taining two parts oxygen and one of air, the other had breathed only atmospheric air. On removing them from the water there was only a slight movement of the lower jaw. At the end of a minute and a half the supcroxygenated kitten arose and totteringly walked around and made an uneventful recovery. The other 144 General Aiiarsthetics in Dentistry. partially recovered at the end of fifteen minutes, but died the next day. These experiments were repeated a number of times, but always with the same results." (Gwathmey.) I stated in the last lecture that nitrous oxid when inhaled does not resolve itself into its com- ponent parts, but remains as nitrous oxid. If you add pure oxygen to the nitrous oxid gas and then inhale it, something very dififerent may happen. Some of the oxygen inhaled passes into the blood to form a loose chemical combination with the red corpuscles ; oxy- hamaeglobin. Life in this way can be supported in- definitely, the oxygen supplying food for the blood, which in turn feeds the tissues while the nitrous oxid is anaesthetizing the patient. Is it not reasonable, then, that I should recommend the use of nitrous oxid gas plus oxygen in all cases in which nitrous oxid is indicated? With nitrous oxid, the period of available anaesthesia is but 30 seconds ; with nitrous oxid and oxygen, you can operate as long as you wish. With pure nitrous oxid, when all air is excluded, "the average inhalation period is fifty-six seconds ; at the end of that time, fresh oxygen must be admitted or permanent asphyxia will result" (Hewitt) ; while with nitrous oxid and oxygen, in proper proportions, there is no asphyxia. All deaths arising from nitrous oxid are supposed to have been caused by asphyxia. The clonic muscular spasms or "jactitation" so common under nitrous oxid rarely oc- curs under nitrous oxid and oxygen. While Andrews, of Chicago, was the first to use nitrous oxid and oxygen as an anaesthetic, Hillischer, General Anaesthetics in Dentistry. 145 of Vienna, was the first dentist to systematically em- ploy nitrous oxid and oxygen in definite proportions. He states that he "has administered 'Schlafgas' to pa- tients of all ages; to those suffering from advanced affections of the heart; to those with diseases of the lungs; and to the subjects of epilepsy and other ner- vous diseases. He further states that he looks upon this gaseous mixture as absolutely without contra-in- dication — that he administers it to every patient irre- spective of any morbid state which may be present. He admits that more experience is needed in adminis- tering 'Schlafgas' (nitrous oxid and oxygen) than in giving any other anaesthetic with which we are ac- quainted ; and there can be no doubt that here, again, he is correct." (Hewitt.) Apparatus. All modern nitrous oxid appliances are so arranged that oxygen can be administered in combination with nitrous oxid gas in definite proportions. This is ac- complished by the addition of a cylinder of oxygen at- tached to the appliance in a convenient position. A second rubber bag is used to contain the Oxygen. These appliances have a "mixing-chamber." The nitrous oxid gas passes from its cylinder into its rubber bag and from thence into the mixing-chamber. The oxygen passes likewise from the oxygen cylinder into the oxygen bag, from which it finds its way also into the mixing-chamber. The two gases combine here in the proportions desired. There is a d^vig? §q adjusted that the amount of 146 General Ancesthetics in Dentistry. . oxygen passing out of the oxygen bag can be con- trolled or regulated. Although not scientifically accu- rate, it is an advance in the right direction. The amount of oxygen necessary to prevent cyano- sis and muscular spasm varies somewhat with the in- dividual. If we rely upon the oxygen in the air to over- come spasm and cyanosis, so much air is necessary that it modifies anaesthesia. On an average, it requires about 8% of oxygen, and in order to abstract that much oxygen from the air it would require 40^ of air. It requires about 92% of nitrous oxid to ansesthetize a patient deeply, so it is evident that if we admit 40% of air in order to obtain 8% of oxygen, we have left only 60% of nitrous oxid, which is about 32% short of the average amount necessary to induce deep anaes- thesia. In other words, in the 40% of air which must be inhaled along with the nitrous oxid in order to fur- nish 8% of oxygen there is 32% of nitrogen that we do not need at all. It is evident, then, that when we uti- lize the air to furnish the requisite 8% of oxygen, we have only 60% of nitrous oxid for anaesthetic purposes, but when we admit 8% pure oxygen direct from a cylinder we have then 92% of nitrous oxid for the pur- pose of inducing anaesthesia. It has been my experience that just a little air ad- mitted along with nitrous oxid is disadvantageous. It prolongs the induction of anaesthesia, increases excite- ment, and there is more jactitation. Hewitt's experi- ments show that patients can be anaesthetized when air is admitted up to 30%. But with 30% of air it re- quired 148 seconds to induce anaesthesia. With 33% General Anccsthctics in Dentistry. 147 of air he failed to induce anaesthesia. With 3% to 5% of air the average inhalation period was 69 seconds. It is well to remember that the higher the percent- age of air admitted, the longer it will take to induce anaesthesia and the lighter will be the resultant anaes- thesia, not on account of the oxygen that is abstracted from the air, but on account of the smaller amount of nitrous oxid that enters the lungs with each inhalation. It becomes very much easier and far more accurate to rely upon oxygen in a cylinder than to depend upon abstracting oxygen from the air. By thus administer- ing nitrous oxid and oxygen, excluding all air, patients can be surgically anaesthetized indefinitely. Teter, of Cleveland, recently anaesthetized a large, obese and plethoric patient, for a currettement and ovariotomy, the patient being under the influence of nitrous oxid and oxygen for two hours ond forty-eight minutes, without one breath of air. Nearly 600 gallons of ni- trous oxid and 80 gallons of oxygen were used. The writer was present on one occasion when Teter main- tained surgical anaesthesia for a period of two hours and thirty minutes without a breath of air. The pa- tient returned to consciousness in less than two min- utes after discontinuing the anaesthetic. Administration. . Nitrous oxid and oxygen, unfortunately, is the most difficult of all anaesthetics to administer. It is without doul)t the safest of all anaesthetics and but for the difficulties attending its adminstration would be the most popular and most generally used of all anaes- 148 General Ancusthetics in Dentistry. thetics. I have already spoken of the difficulties inci- dent to administering pure nitrous oxid, and, in addi- tion to these, we have the added responsibility of feed- ing the oxygen in the right proportions at the right time. It is something that must be learned by re- peated administrations. The more familiar you are w^ith administering pure nitrous oxid the quicker will you become proficient in administering this combined anaesthetic. Just as with pure nitrous oxid, some individuals and some types are more susceptible than others. People enjoying robust health, strong and muscular, full- blooded and active are not as favorable subjects as the frail, the physically weak, and those of tranquil temperament. All people who drink or smoke to ex- cess, whether coffee, tea or liquors, drug fiends and alcoholics, and those addicted to cigarettes and chew- ing tobacco are more difficult to anaesthetize by this method than those of temperate habits. Much depends, of course, on proper breathing; hence stenoses and obstructions of any kind whatso- ever in the mouth, nose, pharynx, larynx, trachea, bron- chi or the lungs interfere more or less with inducing comfortable and successful anaesthesia. At times when the patient does not succumb to the anaesthetic as quickly as usual, showing signs of distress and discom- fort, an examination will often disclose hypertrophied turbinated bones ; deviated septum ; nasal polyp or polypi; enchondroma or osteoma in the nares ; adeno- ma or other growths in the pharynx ; cleft palate, hard, goft, or both ; odoematous or elongated uvulva ; en- General Aiucsthetics in Dentistry. 149 larged tonsils ; enlarged thyroid gland ; impaired lungs, or lungs restricted in their action by adhesions, the re- sult of former intiammatory affections or the presence of pus cavities or encroachment on the lungs of various enlargements and tumor formations. The anaesthetic itself is not always to blame for imperfect anaesthetiza- tion. When a prolonged anaesthesia is to be induced, the patient must be as carefully prepared as for ether or chloroform. Everything that has been said in regard to the chair, the assistant, the mouth-prop, suggestion, arrrangement of instruments, etc., in the lecture on ni- trous oxid is applicable here. All these matters, as insignificant as they may appear to you, must be ob- served if you wish to be successful in administering nitrous oxid and oxygen for dental purposes. While a good assistant is essential to success with pure nitrous oxid, with nitrous oxid and oxygen it is imperative. Hundreds of nitrous oxid appliances have been discarded, others literally thrown out of the office by discouraged and often disgusted operators, because of failure to get satisfactory results, the supposed fault not being with either the nitrous oxid and oxygen or with the appliance, but mostly because of lack of in- telligent assistance. All preliminary arrangements having been made, the patient is now ready to be anaesthetized. The "O" bag should be filled almost full of oxygen and the "NO" bag about two-thirds full of nitrous oxid. There should really be considerable tension on these rubber bags, but not enough to explode them. Place the in- 150 General Anesthetics in Dentistry. haler over the mouth and nose with the anaesthetic shut off. Have the patient breathe deeply and evenly two or three times to test the valves and to see that the adjustment is such as to exclude all air. You NO. 2 LENNOX STAND. These cylinders can be placed at some distance from the chair, in another room if desired, and connected with the appliance by means of small rubber tubing. judge by the sound of the valves as to whether they are in good working order. Satisfied on this point, the anaesthetic may now be admitted. The first few inhala- tions should be of pure nitrous oxid. As soon as duski- General Anccsthetics in Dentistr^' 151 ness of the face is observed, turn the oxygen indicator to "1" at first, then "2," and as the anaesthesia ad- vances, to "4" or "6" gradually. If you should begin ^l!^ Clark Appliance, Lenuox Carriage, large cylinders with pressure Gauges. with "6" or "8," the patient would manifest signs of restlessness and excitement. The frail, the delicate and the anaemic will admit of 152 General Ancesthetics in Dentistry. oxygen in larger proportion in the beginning than the vigorous, the plethoric and the athletic. With the average patient you can advance the indicator five points in about thirty seconds, and in fifty-nine or sixty seconds to "8." The indication for more oxygen is the color of the face. There is no other rule. If the face assumes a dusky hue, the indicator may be ad- vanced still further. In the absence of duskiness and a tendency on the part of the patient to laugh or cry or move the hands and legs, the indicator should be set back a number or two. It is important that the amount of oxygen in the "O" bag should be equal to the amount of nitrous oxid in the "NO" bag. If this is not the case, the nitrous oxid will have more force be- hind it than the oxygen and the proportions can not be maintained. By the use of the larger cylinders equip- ped with pressure regulators, an equal pressure, and the same number of pounds of pressure for each gas can be obtained. As already mentioned in a previous lecture, there should be no conversation allowed while anaesthetizing the patient. Sounds are exaggerated, and the sense of hearing remains intact till the close of the third stage and with some patients is not lost. Talking back and forward between the operator and the assistant, "do this and do that," is enough to defeat any anaesthesia. Suggestions to the patient in a low, quiet, but firm tone of voice, looking to thje quieting of the patient is the only conversation permissible dur- ing the induction of anaesthesia when the assistant is operating the appliance. If I wish more oxygen, "O" is made with the thum1) and first finger; if more nitrous V i. General Ancpsthetics in Dentistry. 153 1 oxid, two fingers are raised, representing an "N." If I wish the oxygen reduced, an "O" with the fingers and y. .' one nod of the head at the same time means set the y oxygen indicator back one notch, two nods two f notches, etc. An "N" with the nod of the head means a reduction in flow of the gas, two nods a greater re- duction. With the new appHances, one lever controls '' both the nitrous oxid and ox\'gen supply, and the 1. operator can act as aUcESthetist, if he so wishes, until ready to operate. Two persons soon learn to work to- -; gether with signals as successfully as a base-ball bat- y tcry. The longer the anaesthesia, the more oxygen will the patient consume as the anaesthesia progresses. Dif- [^ ferent appliances may vary somewhat. I find about "8" per cent, or rather when the indicator is at "8," I get the best results, on the average, in dental opera- tions. For a simple case of extraction, say two or three teeth, for which it would require fifty seconds to ob- tain an available anaesthesia of thirty to thirty-five sec- onds with pure nitrous oxid, an administration of ni- trous oxid and oxygen for a period of about one hun- dred and ten to one hundred and fifteen seconds, would afford an average available anaesthesia of about forty- five seconds. The patient in the former case, in which pure nitrous oxid was administered,- would be cyan- otic and on the border line of dangercnis asphyxia ; in the latter case, enough oxygen would be inhaled to prevent all cyanosis and asphyxial symptt>nis. The First Stage of nitrous oxid and oxygen does 154 General AncBsthetics in Dentistry. not vary materially from the first stage of pure nitrous oxid. The Second Stage is more prolonged than the sec- ond stage of pure nitrous oxid, because the patient does not lose consciousness as quickly. Respiration fre- quently becomes very rapid and deep, and, if the pa- tient shows signs of excitement, too much oxygen is being inhaled and the amount should be reduced. As anaesthesia deepens, the stertor, incident to the last part of the second stage of nitrous oxid anaesthesia, is replaced by gentle snoring; the dusky cyanotic condi- tion of the pure nitrous oxid stage is wanting and in its place a normal complexion. The Third Stage, or the Stage of "Surgical Anaes- thesia," is the one in which the difference is more marked. Instead of deep cyanosis and loud stertor, the patient has the appearance of one in a natural sleep, and even the gentle snoring of the second stage disap- pears. The breathing is regular and quiet. You will remember in the lecture on nitrous oxid that I called your attention to the fact that the tongue became en- larged on account of engorgement of venous blood, and suggested that if the tongue was engorged the same condition must be present in a greater or less de- gree throughout the respiratory tract. This swelling of the tongue is markedly less when anaesthesia is in- duced by nitrous oxid and oxygen, and, of course, the breathing would be less interrupted, and in case the pa- tient should happen to have adenoids, enlarged tonsils, nasal polypi, etc. (such conditions being very com- mon), there would not be the same inconvenience and General Aiucstlictics in Dentistry. 155 danger as would be assumed in administering pure nitrous oxid. In this stage, the pulse is strong, but not as rapid or small as the pulse in the third stage of pure nitrous oxid. It is very much more like the normal pulse, just as the breathing and the complexion is more nearly normal. The eyelids instead of being rolled back, exposing the eyeballs, are usually closed. The pupils remain more nearly normal than otherwise, and the cornea is generally sensitive to touch, and does not lose its sensitiveness during brief anaesthesias. The signs of anaesthesia are very much the same as those of chloroform. The arm if raised falls limp. The breathing is usually quiet and regular, and sometimes, by listening closely indistinct snoring may be detected, the degree depending somewhat on the normality or abnormality of the respiratory channel. The conjunc- tival reflex is lost, and the eyeballs are fixed or may move slightly from side to side, but in a much milder degree than is found in anesthesia induced by pure ni- trous oxid. The Fourth Stage in nitrous oxid and oxygen anres- thesia is wanting. The toxic dose of this anaesthetic is not known. Only a few deaths have been reported during nitrous oxid and oxygen anaesthesia. I have tried to conceive in what way or by what means death could come under nitrous oxid and oxygen properly administered. Surely not from asphyxia as in pure nitrous oxid narcosis; not from protoplasmic poison- ing as with chloroform : not ])y respiratory paralysis as with ether. For purely dental purposes, eliminating 156 General Ancrsthetics in Dentistry. fright and all physical causes, eliminating a tooth lodging in the trachea, or shock, the result of blood collecting in the throat, both of which are incidental causes only, I cannot conceive of death occurring as the result of administering nitrous oxid and oxygen. Nitrous Oxid — Oxygen — Carbon Dioxid — Anaesthesia. Investigations made in the United States the past two or three years by Yandell Henderson and associ- ates of New Haven, Mosso of Turin, and others abroad, have proven beyond doubt that carbon dioxid is not as formerly supposed a waste product of the body, but that it is one of the body's most important hormones. It exercises a regulative influence on the action of the heart, on the tonus of the blood vessels, and especially upon the respiration. In fact, breathing in ordinary life is practically dependent on the stimulation afforded to the respiratory center by the carbon dioxid brought to it in the blood. (Ettore Levi, Florence, Italy.) A discovery of greater importance than this to anaes- thetists can hardly be conceived. After reading Hen- derson's paper Levi was inspired to experiment with mixtures of carbon dioxid for the purpose of stimulat- ing the bulbar centers in those cases in surgical prac- tice in which, owing to the effects of chloroform and ether or to operative trauma, or to a combination of these causes, the automatic activity of these centers is temporarily paralyzed. The experiments of Levi showed that in carbon dioxid properly diluted we pos- sess a therapeutic agent of extraordinary potency. He experimented on animals, inducing failure of the res- General /Inccsthctics in Dentistry. 157 piration by means of the single or combined action of nitrites, chloroform, and morphin. These animals were then made to inhale a mixture of oxygen with various percentages of carbon dioxid — from 10-30%. In every case there was an almost immediate return of breathing. He then tried the administration of these gas mixtures to patients who, because of trauma or ex- tensive or prolonged operation, had sunken into a par- tial or completely comatose state. The effects were at times brilliant, especially in those cases where the breathing had become shallow, or irregular. The most satisfactory results were obtained with a mixture con- taining 15 per cent of carbon dioxid. In cases where the respiration was decreased (Cheyenne-Stokes type) the periodic rhythm was immediately stopped and nor- mal breathing was not only restored, but continued some time after the inhalation was ended. In such cases not only was respiration improved, but there was a marked improvement in the condition of the circu- lation. The disappearance of cyanosis was one of the most striking features. Burci of Florence has so much faith in the efficacy of this mixture that prior to every operation a gasometer containing a mixture of oxy- gen and carbon dioxid is prepared, and during the operation is available for immediate use of his assist- ant administering the aniesthetic. If at any time the patient shows evidences of the slightest tendency to failure of respiratory or cardiac functions, he admin- isters immediately inhalations of this gas mixture and does not wait till profound shock or respiratory paraly- sis is reached. A rapid return of normal heart action 158 General Anccsthetics in. Dentistry. and breathing is the almost invariable result. The number of cases thus treated during the past two years at the surgical clinic of the Florentine university now amounts to several hundred. In no case has any ill ef- fects been observed from such treatment. In several traumatic cases in which breathing had entirely stop- ped, under chloroform anaesthesia, a prompt return to normal breathing occurred. In a case of suicide by hanging, after prolonged artificial respiration, inhala- tions of oxygen and hypodermic stimulation had not given the slightest results, upon administering the car- bon dioxid mixture after a few inhalations spontaneous respiration returned. A mixture of from 10-15 per cent of carbon dioxid after the completion of an operation is very effective in causing a prompt awakening of the patient. It seems also to tend to decrease post-chloroform vomiting. This is probably because of the rapid elimination of chloroform from the blood and tissues under the influ- ence of the increased respiration induced by carbon dioxid. (An epitome of Levi's paper in Journal A. M. A., March 16, 1912.) As the result of these experiments of Yandell Hen- derson and others the entire anaesthetic procedure now in vogue may have to be modified. McKesson of To- ledo, and others, were quick to recognize the impor- tance of these discoveries, and immediately set about to construct anaesthetic appliances by which carbon dioxid could be used in connection with nitrous oxid- oxygen anaesthesia, and also with ether and chloro- General Aiucsthetics in Dentistry. 159 form. A re-breathing chamber or compartment is ar- ranged, so that with each inhalation of nitrous oxid, ether, or chloroform a percentage of carbon dioxid is admitted. In this manner the patient utilizes his own carbon dioxid, and McKesson further shows that this re-breathing procedure results in an actual saving of seventy-three gallons per hour of nitrous oxid, and be- sides makes the anaesthetic safer. It would seem then, that in the near future, especially in prolonged anaes- thesias, the re-breathing method, or the admixture of carbon dioxid independent of what is exhaled, will re- ceive attention and be utilized. Another step in advance has been scored in that we not only have a safer method of administering anaes- thetics, but have gained a most important and poten- tial therapeutic agent for resuscitation of the patient in cases of impaired respiration and circulation during anaesthesia. It occurs to me, in the light of these new discov- eries, that the manufacturers of nitrous oxid and oxy- gen should also prepare for our use cylinders contain- ing 85% of oxygen and 15% of carbon dioxid, and that everybody administering either local or general anaesthetics procure one of the tanks and have it in readiness in case it was needed. It also occurs to the writer, that experiments should be made with this combination in various percentages and results carefully studied. If it can be shown that such a combination maintains normal respiration and circulation more surely than oxygen alone, then why 160 General Anccsthetics in Dentistry. not make such a combination as a substitute for pure oxygen when administering nitrous oxid and oxygen. Such a procedure would be very much easier and far more satisfactory and obviate a special device thus further complicating anaesthetic appliances. THE GWATHMEY APPLIANCE. General Anesthetics in Dentistry. 161 LECTURE XIII. Nitrous Oxid and Oxygen in Operative Dentistry. With most dentists, the word anaesthesia is synony- mous with extracting- teeth. Ask the average dentist if he uses general anaesthetics and he will say, "No, I do not extract more than three or four teeth a month in my practice and have no use for anaesthetics." If anaesthetics meant no more to me than the mere ex- traction of teeth, I would not have prepared these lec- tures, I can assure you. The dental surgeon should use anaesthetics in all painful conditions. One of our most eminent oral surgeons, Dr. G. V. I. Brown, told me recently, that if he should resume the general prac- tice of dentistry he would use nitrous oxid a thousand times where formerly he had used it but once. The possibilities of this anaesthetic, especially in combina- tion with oxygen, had not been realized until he was called upon to use it so often in his oral surgery prac- tice. In what class of cases would I use nitrous oxid and oxygen ? In all painful conditions the dentist is called upon to treat : Sensitive cavity preparation ; removal of pulps surgically, and sometimes after an arsenical ap- plication has been made ; shaping teeth for crowns or abutments whether alive or devitalized, for in one 162 General Anccsthetics in Dentistry. instance they are exquisitely sensitive, in the other the grinding and cutting is more wearing on some patients than a real "hurt" ; adjusting cervical or pain- ful clamps; treating pyorrhoea; rapid wedging of the teeth to gain space for filling ; opening into teeth af- fected with pericementitis or acute alveolar abscess ; lancing abscesses; opening into pulps for the purpose THE TETEE NASAL INHALER. of making an arsenical treatment — in short, all pain- ful or fatiguing operations on the teeth. Once familiar with operating under analgesia or anaesthesia you would relinquish dentistry rather than practice as you are now doing. You may think you know, but you do not know the first letter in the word "gratitude," nor will you know till you have looked into the eyes and faces of yonr patients wlien they leave the chair after using nitrous oxid and oxygen. General Ancesthetics in Dentistrv. 163 The most sensitive cavities can be prepared, the most painful conditions rendered absolutely painless by this method. It is seldom necessary for the patient to lose consciousness; it is a stage of analgesia rather THE TETEK 1-Mi'l^OVED APPAKATUS XO ^ WITH VAPOR WABMER AND STAND. ' than anaesthesia, the patients once in a while momen- tarily passing into unconsciousness. Have the patient understand he is not to be hurt, that the whole matter is, under his control. Adjust the 164 General Ancusthetics in Dentistry. rubber dam, insert the mouth-prop, apply the nasal inhaler, as explained in the last lecture. Instruct the patient to raise the hand if he feels pain ; keep up a running conversation with the patient like this : "Am I hurting you ? Do you feel pain ? Do you mind what The Orefrg inhaler consists of a steel bow, padded at each end, extending from the forehead to the bnse of the skull. This bow supports the tubing and exhalation valve by means of two small spring clips. The tubing extends from the nares back over the head to the gas apparatus. In order to adjust the appliance simply place bow on the head by opening it, according to size of head, pull tubing forward through spring clip so as to bring it firmly into the nares. The advantages of the inhaler are: Its quick adjustment, about ten seconds or less, and perfect comfort when in ])osition. It does not interfere with o))erationH in the mouth. Does not depress the upper lip. Does not suggest smothering by covering the nose, and is very easily kept clean, General Ancesthetics in Dentistry. 165 I am doing? Are you asleep?" etc., etc. You can keep patients in this condition indefinitely, and they will be resuscitated in two minutes after discontinuing the angeestlietic and leave the office buoyant and happy, not dreading to return for the next appointment. And the operator — that all-gone, all-used-up, collapsed feel- ing, that five o'clock feeling, is gone to return no more. The rubber dam adjusted, you need only the nasal inhaler. Instruct the patient to breathe rather deeply the first four or five inhalations, then assume natural breathing. Begin by breaking down enamel walls with a chisel or proceed gently with a bur, the hand to be raised if pain is felt, if the operation is the preparation of a carious tooth. If the patient's face shows the slightest cyanosis, indicate oxygen, and have the as- sistant admit a little more oxygen ; this is usually suf- ficient, but varies with the individual. Maintain this a while if the patient does not become cyanotic again. If the patient shows a tendency to laugh, or manifests signs of stimulation, diminish or discontinue the oxy- gen. It is simply a matter now of administering just enough of the combination to get results. If you find the patient going down too deeply, discontinue or diminish the anaesthetic for a few inhalations. You will soon learn the stage in which to operate, by practice. All that has been said about preparation of the pa- tient is applicable here. A light breakfast or a light lunch must be insisted upon. Loosen all bands, have the corset removed, and the bladder should be empty. When you know in advance that you are to operate 166 General Anccsthctics in Dentistry. ANESTHETIC INDUCTION. THE DeFOKD NITEOUS OXID AND OXYGEN INHALEE- NASAL. This inhaler is unique in that it provides a mouth cover which excludes the entrance of air through the mouth while patient is being anajsthetized. When patient is ready for the operation the mouth cover is everted and held up out of the way. All during the o))eration the patient inhales through the nose, and if signs of resuscitation are noticed before the completion of the opera- tion, the mouth cover is dropped to its position over the mouth, and surgical ana-sthesia is quickly induced again. This inhaler is intended to be used with any nitrous oxid appliance. General .liucstliefics in Dentistry. 167 under aiuesthcsia, tlic patient can l)e instructed in re- gard to loose clothing- and dress accordingly. Those who do not insist on these precautions never attain the same degree of success. An anaesthetic clinic is the most difficult of all clin- ics in which to get satisfactory results, and those who see anaesthetics administered at clinics only, have little appreciation of what can be accomplished in the quiet of an office with proper surroundings. Everything depends upon the tranquillity of mind that can be in- duced, and there is little chance for this in a public clinic. If the patient is a woman, the possibilities of saying or doing something improper tends to excite- ment and restlessness of mind rather than quiet and composure. One of the most successful public anaesthetic demonstrations I have ever witnessed was conducted by Dr. Jessie Ritchey DeFord, of Des JMoines, at the Fourth Annual Alumni Clinic of the College of Den- tistry, State University of Iowa, Iowa City, February 4th, 1907. The operator had never operated upon teeth before under anaesthesia. His clinic was to make a porcelain inlay in an upper right cuspid labial sur- face, gingival cavity. Indeed, this was his first ap- pearance as a clinician. The tooth was so sensitive that the patient could not stand even drying it with absorbent cotton. lie objected to taking nitrous oxid and oxygen because, on a previous occasion, he was made very sick from ether. He had three or four other cervical cavities and finally consented to take the anaes- thetic under two conditions. The first was that the 168 General Ancrsthetics in Dentistry. preparation of the cavity should be painless, and, sec- ond, that all the cavities should be prepared for fillings if he found he was not being hurt. The doctor pro- ceeded with the anaesthetic as I have described, and the patient, a dental student, at no time lost consciousness, and when the first cavity preparation was completed said, "Go on with the next one, I am not being hurt, I am having the time of my life," and during the twenty- five minutes consumed in cavity preparation, he never once raised his hand to indicate he was feeling pain, and said a dozen times, "I am not minding it, there is no pain, go ahead." He made this request, however, "My throat is getting cold, please add more warm water." Here was a patient that had no confidence in the anaesthetic for such operations, and an operator who was naturally embarrassed and timid, having never before operated under an anaesthetic, or even at a clinic, yet the result was, as I have described it, and you can hardly imagine a more trying ordeal for the anaesthetist. The same anaesthetist later in the day in- duced a thirty-minute anaesthesia at the University Hospital with nitrous oxid and oxygen for an opera- tion on the soft palate performed by Dr. G. V. I. Brown. General Anccstlictics in Dentistry. 169 LECTURE XIV. Ethyl Chloride. Physicians have long sought an anaesthetic agent as quick in its action as nitrous oxid, as free from danger as nitrous oxid, with as little after disturbance, yet one with which a longer period of anaesthesia could be obtained without the cumbersome apparatus inci- dent to nitrous oxid narcosis. Ethyl chloride when first introduced was supposed to be the long-waited-for agent so devoutly desired. This anaesthetic was first used by Heyfelder, in 1848. In 1880, a committee of the British Medical Associa- tion after experimenting on animals, rendered an ad- verse report, and its use was abandoned. In the year 1895, Carson and Thiesing revived ethyl chloride and it was used to some extent by dentists. This same year Soullier, of Lyons, reported its use in 8,417 clini- cal cases without a fatality. The first real scientific work, however, is said to have been done by Lotheisen and Ludwig in Prof, von Hacker's clinic in 1897-98. McCardie, in 1902-03, studied the value of this drug in 620 general narcoses and was enthusiastic in his praise of this agent, claiming that it contains all the requisites of a perfect anaesthetic ; and these we find set forth bv Tuttle as : 170 General Ancesthetics in Dentistry. 1. Safety. 2. Insensibility to pain. 3. Complete relaxation. 4. Easy and rapid production of effect. 5. Freedom from dangers and disagreeable after- effects. 6. Simplicity of administration. Tiittle believes, too, that these requisites are nearly all inherent in ethyl chloride. (Montgomery and Bland in Jour. A. M. A., April 2, 1904.) Chemically, ethyl chloride is one of the haloid substitutions derived from ethyl alcohol, and it is formed by the halogen element, chlorine, replacing the hydroxyl group in the alcohol. Those who claim that the heart's action in the be- ginning is increased are in the majority. These, how- ever, admit that the circulation returns to normal as soon as anaesthesia is induced, and that this primary disturbance is due to nervous excitement rather than direct influence of the drug, an experience common to the administration of any ansesthetic. While some have sought to show that arterial tension is increased, others are as positive that arterial tension is dimin- ished. I think this difference of opinion has arisen be- cause some investigators have experimented during a light anaesthesia, while other observers have made their observations during deep anaesthesia. Wood found that upon anaesthetizing animals to a deep narcosis the arterial tension was lowered, but, when the anaes- thetic was discontinued, the arterial tension regained General AiicFsthetics in Dentistry. 171 the normal ; so it is possible that in some of the experi- ments that have been reported that the narcosis was not deep enough to lower arterial tension. Koenig not only believes that the arterial tension is lowered in deep ethyl chloride anaesthesia, but says it is due to the influence of the agent on the pneumogas- tric, because it disappeared after the vagi were cut in animals. Malherbe and Roubinovich made a test of twenty- four cases with Potain's sph}gmomanometer to ascer- tain the action of ethyl chloride on arterial pressure in man. "Of the twenty-four cases examined by Mal- herbe and Roubinovich, arterial tension was decreased in twenty-two, and the frequency of the pulse-beats followed equally the modifications in the degree of arterial pressure ; during deep sleep diminishing and increasing and attaining finally the normal number as consciousness was restored." McCardie concludes that the pulse is slower than normal in deep amesthesia, but that its regularity is maintained. Montgomery and Bland found that in patients with a normal circulatory apparatus there was usually a slight decrease in arterial tension. There was no de- cided disturbance in the pulse-beat. At the beginning of the administration, however, there -was a certain in- crease in the frequency of the j^ulsations, but this, of course, was due to the psychic disturbance of the pa- tient, and not from any direct action of the drug. The respirations were generally stimulated both in fre- (juency and depth. 172 General Ancesthetics in Dentistry. There is little if any irritation to the respiratory mucous membrane and this is a point well worth remembering, as collection of mucus in the pharynx under ether anaesthesia sometimes almost defeats suc- cessful operating. Another feature worthy of men- tioning is that the tongue does not swell or increase in size under ethyl chloride anaesthesia as it does under nitrous oxid narcosis. Unfortunately eth}^ chloride narcosis is followed frequently by nausea, and but for this disturbing ele- ment would be far more popular and even more ex- tensively used than at present. Headache is more commonly experienced after an administration of ethyl chloride than after an adminis- tration of nitrous oxid gas. Another thing to be re- membered is that according to Luke, ethyl chloride has an affinity for the masseter muscle and the spasm is sometimes so severe that it is difficult to find a mouth-prop that will withstand the strain. * Safety. I consider ethyl chloride, in careful hands, one of the safest of anaesthetics. It, of course, has its limita- tions, and I think nearly all mortalities reported as re- sult of using this anaesthetic have been due to care- lessness, improper administration, or attempting too prolonged an anaesthesia. Most of the mortalities re- ported have occurred abroad, and you must take into consideration that "abroad" means usually that the "closed" method has been employed, air excluded. Soullier and Lyons report 8,417 cases without an General Anccsthctics in Dentistry. 173 adverse symptom. Seitz rei)orts but one death in 16,- 000 cases collected by him, and this death occurred in a case in which ethyl chloride was contra-indicated. Ware reports one death in 8,207 cases, and the death was probably the same one reported by Seitz. Mc- Cardie asserted "that it was the safest of all anaesthet- ics except nitrous oxid, and that the death rate might be placed at one in many hundred thousand." He has since somewhat modified his views, but as late as March 17th, 1906, in The British Medical Journal, says: "Fortunately, in an experience of nearly 2,000 cases 1 have not seen either asphyxia or syncope during its administration." Again, he says: "Since 1897, ethyl chloride has been very rapidly growing in popularity, so much so, indeed, that it has, unfortunately, largely, and in some places altogether replaced nitrous oxid. For instance, in the General Hospital, Birmingham, the latter is rarely used at all save in the dental depart- ment. The reasons for this popularity are those that make chloroform so favored : ethyl chloride is rather pleasant to inhale, is non-irritating to the air-passages, and, more than all, it is most pleasant and easy to ad- minister." Weissner states that in Von Hacker's clinic in Innsbruck, that ethyl chloride is used when ether and chloroform are contra-indicated in high degrees of cir- culatory interruption, fatty degeneration of the heart, diseases of the respiratory organs, persons enfeebled by great loss of blood and those suffering from nerve shock. Luke, of Edinburgh, in his "Guide to Anaesthetics" 174 General Aiucsthetics in Dentistry. says: "In the past two years ethyl chloride has made enormous strides in this country and bids fair to be the most frequently employed anaesthetic which we possess. It has almost completely displaced nitrous oxid in gen- eral surgery." Luke places the death rate at one in 12,000. Lothei- son thought ethyl chloride to be "quite harmless," and in April, 1902, reckoned the mortality to be one in 17,000. Administration. Ethyl chloride may be obtained in capsules and in tubes. The tubes usually contain about sixty cubic centimeters, but the quantity varies with different manufacturers, and some manufacturers make two or more sizes. The larger tubes are fitted with a spray attachment. These tubes, some of them at least, are graduated so that the amount of material being used for anaesthetic purposes can be seen. For the purposes of general anaesthesia, the ethyl chloride is sprayed from these tubes into an inhaler. The capsules are made of glass and usually contain from three to five cubic centimeters hermetically sealed. There are a number of inhalers on the market and these are so arranged that ethyl chloride can either be sprayed into the inhaler or one of the capsules frac- tured and its contents discharged upon a piece of gauze arranged for that purpose. An ethyl chloride in- haler may be improvised by modifying somewhat an Esmarch chloroform inhaler. The Esmarch in- haler, as you will recall, consists of a wire frame General AnccstJictics in Dentistry. 175 over which is stretched a piece of stockinet or surgeon's gauze, which extends over the edges and is clamped down. Over this surgeon's gauze is stretched a piece of rubber dam. Clamp the rubber dam down with the gauze, and from time to time spray a small quantity of ethyl chloride on the gauze lift- ing it away from the face just as the patient completes an inhalation. This can be accomplished while the pa- tient is exhaling, and does not interfere seriously with the administration. It takes longer to anaesthetize a patient and more material is used than when employ- ing one of the many inhalers supplied by the dental and surgical dealers. Both the Stark and DeFord somnoform inhalers are excellent ethyl chloride inhalers. As these ap- pliances and their use are described in the somnoform lecture, it will not be necessary to refer to them in this lecture except by name. In the administration of ethyl chloride we have the choice of two methods ; namely, first, in which all air is excluded, and second, in which various amounts of atmospheric air is admitted to the lungs along with the ethyl chloride. With breathing a little deeper than normal, in twenty to thirty seconds light anaesthesia is induced. If the patient is large and muscular,- after four or five inhalations it is sometimes necessary to add ain^ther c. c. At that point where consciousness is lost, "the patient often quits breathing for from five to twenty seconds." About this time, the patient may become stimulated or excited, move the feet and erab at the 176 General Anccsthetics in Dentistry. bag. Then consciousness is lost, the pupil dilates, the eyeballs roll, and the respiration becomes deeper and slower. At this stage, two or three teeth may be ex- tracted and the patient not feel the pain ; affording a working period from twenty to forty seconds. If there is sufficient anaesthetic in the bag, and the patient is permitted to breathe about ten seconds longer, we get a very profound anaesthesia which will last from one hundred to one hundred and twenty seconds. At this time, the corneal reflex is abolished, the face reddens slightly and sometimes perspiration appears on the face. If the anaesthetic is discontinued at the end of the first stage, the patient awakes suddenly like one coming out of a hypnotic sleep. In the deeper anaes- thesia just described, most patients recover quickly, but there is with all a dreamy or drowsy stage just before awaking, and after awaking, with many, they close their eyes again for a secondary nap of a few seconds. Just before awaking is the time when neuro- tic women and alcoholics make trouble, if they are to become excited after the operation. It is a dangerous procedure to try to forcibly restrain either class men- tioned. Neurotics and alcoholics occasionally become excited going under, but ordinarily it is just before awaking, if they make trouble at all, that you must be on your guard. Do not try to restrain them and you will seldom have trouble. Cyanosis is a rare condition during ethyl chloride anaesthesia, and if it should be present, it arises not frgm the ethyl chloride itself, but rather from some General Aiurstlietics in Dentistry. 177 mechanical interference of the respiration, as swalknv- ing the tongue. In the stage of Hght anaesthesia, there are seldom any unpleasant or disagreeable after-effects. The pa- tient is awake and entirely himself in about a minute from the time the first inhalation is taken. Following the second condition described, in which the anaesthesia induced was of a very profound nature, tiausea and headache are sometimes present. I am in- clined to the view that nausea and headache following the administration of ethyl chloride, when the "close method" is employed, are caused not so much from the ethyl chloride itself, but is rather tlie result of re-inhal- ing the contents of the rubber bag. I dare say if any inhaler be used in exactly the same manner and be held the same length of time over the nose and mouth, and a given num1)er of pa- tients inhale and rc-inhale the contents of the bag, without ethyl chloride being added, a certain number of those trying the experiment will experience nausea and headache. Blood entering the stomach nearly al- ways produces nausea. The anaesthetic should not be held responsible for nausea, the result of swallowed blood. The Stark and DeFord inhalers are so arranged that the amount of anresthetic and .the amount of air entering the lungs can be very accurately gauged. I am an advocate of the open method in administering ethyl chloride, just as T prefer the admission of air freely in the administration of ether, chloroform and somnoform. Take a 3 c. c. capsule of ethyl chloride, 178 General Anccsthetics in Dentistry. place it ill its compartment in the Stark or DeFord inhaler, with the appliance in position, and the patient ready, fracture the tube. For the first two or three inhalations, admit all air, then just a little ethyl chloride, then a little more, then a little more. Now all air may be excluded and the patient permitted to breathe once or twice and usually an available anaes- thesia of about ninety seconds can be obtained. You can regulate the depth of the anassthesia to suit the operation to be performed. Nausea and headache fol- lowing the administration of ethyl chloride with an admixture of air is less frequent than when all air is excluded. As ethyl chloride is administered in the same kind of an appliance as somnoform and both preparations are sold in the same kind of containers and in the same-sized tubes and capsules, the reader, for a more minute description of the administration of ethyl chloride, is referred to the lecture on administra- tion of somnoform. As the difficulties and dangers encountered in ethyl chloride administration are also the same as those aris- ing from somnoform anzesthesia, these will be found to be very fully discussed in the somnoform lectures. General AtKcstlictics in Dentistry. 179 LECTURE XV. Somnoform. We are indebted to Dr. G. Rolland, of Bordeaux, France, for the ancesthetic mixture which he has named somnoform. In 1895, Dr. Rolland organized the Bor- deaux Dental School, and to him was assigned the chair of anaesthesia. Not being satisfied with the anaesthetics in general use for dental purposes, he ex- perimented with various anaesthetic mixtures till 1899, when he made public the results of his research. He maintained that an ideal anaesthetic should be one that "would enter into, sojourn in, and make its exit from the organism in the same manner that oxygen does; that the tension of the anaesthetic agent should be greater than that of oxygen in order that it might take the place of oxygen in the lung alveoli ; and that, according to the laws of the physiology of respiration, tension produces two classes of phenomena which al- ternate and are opposed to each other, namely, absorp- tion and elimination, and, as the degree of volatility of a gas determines its pressure, the more volatile a gas, the more easily it can be absorbed, and consequently the more easily it can be made to take the place of oxygen." Just as the red blood corpuscles are charged with 'oxygen, during inhalation and distributed to the tissues. 180 General Ancesthetics in Dentistry. so will somnoform be absorbed. It is estimated that it takes about thirty seconds from the time the blood leaves the lungs charged with oxygen until it returns laden with carbon dioxide. A given red corpuscle, then, would have fed out all of its oxygen in about fifteen seconds. Rolland argued that, as the oxygen of the blood is consumed in about fifteen seconds, the ideal anaesthetic should be as rapid in its action, and experimented along that line. In the chloride of ethyl, we have an anaesthetic agent almost as rapid in its action as somnoform, but no doubt Rolland satisfied himself that this agent was not volatile enough and had too high a death rate. Bromide of ethyl evidently did not meet his approval. This latter agent is not as volatile even as the ethyl chloride. Methyl chloride is more volatile than either of these agents and no doubt is added to the ethyl chloride and the ethyl bromide on account of its rapid evaporation, thus increasing the tension of somnoform and causing it to be more rapidly absorbed and more quickly eliminated. It is said that methyl chloride volatizes at twenty degrees below zero, and it is this agent that makes somnoform so volatile. Somnoform is composed of Old Formula. New Formula. Ethyl Chloride 60% 83% Methyl Chloride 35% 16% Ethyl Bromide 5% 1% I am inclined to think that this is a raechanicat General Aiucstlwtics in Dentistry. 181 mixture rather than a chemical compound. Ijv exclud- ing all air, anaesthesia can be induced in about fifteen seconds. I believe this to be due to the difTusibility of the meth}d chloride. The mcth}^ chloride possesses anaesthetic properties of its own, and of the three agents would naturally evaporate quicker than the others, carrying some of their vapor along with it. In the matter of volatility, the ethyl chloride comes next, and serves to prolong the amesthesia, and the ethyl bromide would naturally evaporate more slowdy than the others, maintaining the anaesthesia as the other agents would be more rapidly eliminated. We know that with nitrous oxid the average induc- tion period is forty-four seconds, and the average avail- able period of anaesthesia is thirty seconds, while with somnoform, when all air is excluded, the induc- tion period is from fifteen to thirty seconds, and the period of available anaesthesia from sixty to three hun- dred seconds. I have noticed in using the large somnoform tubes that after two or three anaesthesias have been induced the bromide odor becomes more pronounced, and when nearly empt}- the odor is aluKxst that of pure ethyl bromide, and it is from this fact that I have come to believe that somnoform is not a chemical compound, but a mechanical mixture, and that each ingredient is inhaled in proportion to its volatility. I do not mean by this that the patient gets at first all or nothing but methyl chloride, then the ethyl chloride, and after these the ethyl bromide, because the methyl chloride no doubt carries some of the va])or of both of these 182 General Ancesthetics in Dentistry. agents along with it ; but I do believe that in a general way, with somnoform, we get an anaesthesia character- istic of each agent in a modified form. For instance, there is less muscular spasm during somnoform anaes- thesia than in the anaesthesia induced by ethyl chloride ; there is less nausea following somnoform anaesthesia than with ethyl chloride or ethyl bromide alone ; som- noform anaesthesia is more tranquil than ethyl chlo- ride anaesthesia, somnoform anaesthesia is superior in every respect to the anaesthesia induced by either ethyl bromide or ethyl chloride. As to safety, somnoform outclasses both ethyl chloride and ethyl bromide, and it is difficult to explain why there should be such a discrepancy in the mor- talities incident to these anaesthetics. Ethyl chloride and ethyl bromide are administered almost universally by physicians and professional anaesthetists, the patient having been prepared in advance ; while somnoform has been administered mostly by dentists, many of them purchasing appliances and administering it with- out any experience whatever. Dental salesmen were sent out from almost every dental depot in the United States, and actually instructed dentists in the use of somnoform ; many of these salesmen, prior to this, had never seen an anaesthetic administered ; yet, when you compare the death rate of these anaesthetics, two being administered almost entirely by physicians and pro- fessional anaesthetists, and the other by inexperienced dentists and traveling salesmen, the results obtained are almost beyond belief. The death rate of ethyl chloride is estimated at about one in twelve thousand. General Aiiastlietics in Dentistry. 183 The death rate of ethyl bromide is one in about five thousand administrations. Combining these two anaes- thetics with nictliyl chloride in the proportions men- tioned we have soninoform, with a mortality of about six in two million administrations. It might almost seem that I must be mistaken in saying- that somnoform is a mechanical mixture, but rather that it is a chemical compound, the safety of which is infinitely greater than the safety of its con- stituent parts. I have been asked hundreds of times if I considered somnoform as safe as nitrous oxid gas. This is rather a difficult question to answer. The an- swer can not be gi\en "yes" or "no" without going somewhat into details. If all air is excluded in admin- istering nitrous oxid gas, Hewitt says, the average time in which dangerous asphyxia is produced is fifty-six seconds. This, he also says, is the average time of com- plete anaesthesia. It is not true of any other anaes- thetic with which I am accpiainted, that the stage of surgical anaesthesia and the danger point is the same. We are always in danger, then, with nitrous oxid, according to Hewitt, when the patient is surgically anaesthetized. But, before we reach this point with nitrous oxid, the distress of the patient is so great and the symptoms so alarming, that few men are brave enough to really an;csthetizc their patients and opera- tions are nearly always performed before surgical anaes- thesia is induced, and this is the reason that so many fail with nitrous oxid gas. The patient feels and knows everything that is done, because he is not surgically anaesthetized. Most operations under nitrous oxid 184 General Ancesthetics in Dentistry. are performed in the analgesic rather than the anaes- thetic stage, and a large number are absolute failures, and it would have been better for both the patient and the operator, had nitrous oxid not been administered. Discredit is brought upon a good anaesthetic and often upon a good appliance by attempting extraction and surgical operations when the patient is not surgically anaesthetized. I say without hesitancy, that I con- sider the stage of surgical anaesthesia induced by pure nitrous oxid as dangerous, and even mor6 so, than the stage of surgical anaesthesia induced by somnoform. I will also add that, if from fear you stop short of the stage of anaesthesia with somnoform, as is nearly al- ways done with nitrous oxid, you can accomplish as much again with somnoform as with nitrous oxid and not hurt your patient or have them struggle and resist as they do under nitrous oxid. There is this to say in favor of nitrous oxid, that the "leave-off" symptoms are very pronounced, while with somnoform this is not the case. There is no cyanosis, no jactitation, no rolling of the eyeballs or stertorous breathing, but a beautiful tranquil sleep in most cases and nothing alarming to either the anaesthetist or any friend that may be present. Approaching anaesthesia can always be told when somnoform is the anaesthetic employed, as surely as when nitrous oxid is used ; l^ut when surgical anccsthesia is induced with somnoform, the patient is in a condition of safety, while, when the stage of surgical anaesthesia is reached under pure ni- trous oxid, the patient is dangerously asphyxiated. You can produce death with these anaesthetics by General Ancesthctics in Dentistry. 185 holding the inhaler tightly over the nose and face, excluding all air, hut with proper precautions and care- ful watching- death rarely occurs under any anaesthetic. In more than six thousand somnoform anaesthesias, I have never witnessed an alarmini^ or dangerous symptom. Somnoform is a transparent liquid preparation ready for use, in glass tubes and capsules, sold by all dental dealers, the tubes contain sixty grammes, while the capsules are made in two sizes, one containing 3 cubic centimeters and the other 5 cubic centimeters. To the tubes or bottles is attached a valve by means of which the somnoform is sprayed into the inhaler. These tubes have a centimeter scale on the side and the distance from one division line to the other contains 5 c. c. In spraying into the inhaler, the tube is turned valve end down and held in a perpendicular position. As soon as the somnoform steadies itself, you note its position on the scale ; it settles in the bottle as it is sprayed out. It only took the contents of two of these tubes to con- vince me that the capsules must be preferaljle. Unless the entire contents of one of these tubes is used in a short time, the unused portion has a peculiar odor, and the longer it remains in the tul)e the more offen- sive it becomes. I thought at first that the materials forming this mixture had decomposed.- l)ut later it oc- curred to me that the valve no doubt leaked a little and that the more volatile constituents of the somno- form were evaporating leaving the heavier bromine proportion. This, I am satisfied, is exactly what hap- pens to the contents of the 60-gramme tubes. Upon in- 186 General Anccsthetics in Dentistry. quiry I have ascertained that those dentists who com- plain most about somnoform producing nausea have been using the large tubes. ! A SOMNOFOEM CAPSULE. BOX IIOLDINCi TWELVE CAPSULES. Luke says that ethyl f^romidc used as an anaesthetic is followed by nausea in forty-five per cent, of the administrations made. General Aiiccstlwtics in Dentistry. 187 The capsules are hermeiically sealed, there is no opportunity for leakage or decomposition and we al- ways know the exact quantity with which we have to deal. For a period of three years, I confined myself to the use of the 5 c. c. capsules, taking it for granted that with that amount of somnoform I could get a better result than by using the smaller size. On one occasion my dealer being out of 5's, I pur- chased 3's and have used them almost entirely ever since. Even with the 3's I am confident that not more than half of the contents of these smaller tubes are used, and I find myself wishing that the manufactur- ers would make a tube containing but two cubic centimeters. The Stark Inhaier. The Stark inhaler may be said to consist of three parts. The face-piece is made of metal instead of cel- luloid and this permits of its being boiled before and after use just as any other surgical appliance. Inside of the Stark metal face-piece is soldered a piece of metal gauze. When somnoform is to be followed by ether or chloroform, a piece of surgeon's gauze is placed in the face-piece on the metal gauze. As soon as the patient is deeply anaesthetized with scMunoforni, the face-piece is detached from the appliance and now becomes an ether or chloroform inhaler, the drop method being employed. The change can be made in the fraction of a second and the ether or chloroform simply dropped on the surgeon's gauze. In the hori- 188 General Ancesthetics in Dentistry. zontal tube is an opening on each side for the admis- sion of air. Just back of these openings is a device for regulating both the amount of air and the amount of somnoform that shall be inhaled by the patient. This STAEK SOMNOFOEM INHALER. device is regulated by means of a small handle or lever moved backward or forward by the thumb of the hand that holds the inhaler. By means of this simple device the amount of somnoform inhaled can be regulated to General Aiucstlietics in Dentistry. 189 a certainty. If you so wish, all of the somnofonn can be excluded and only air admitted. The patient with INFLATAHLE RUBBER MARGIN SEE LARGER ILLUSTRATION BELOV> LEVT.R AND SLint ClOSINd AlK V SOM>iOKOHN Aft* OPKNING TtLBSCOPlNG CAl' CAI'SLI.E (CHAMBKH VALvfe SOMNOFOHN V\Lia AlH OPKNINGS LEVKR CONTROLLING BOTH KRAMEWOHK SF-PAHATES TO pMPTV BROKEN Ola«5s hkli> by (.AtZE WIHKS TO SUPPORT LUST COVERS WIRES AND LINT SHOULDER AND FLATMGE SUPPORTING BAG DETAILED CONSTRUCTION OF STARK SOMNOFORM INHALER. the inhaler in position, can breathe for any length of time desired without "getting so much as a trace of the 190 General Anaesthetics in Dentistry. anaesthetic. You can admit just an odor, at first, and increase it as slowly or as rapidly as you desire for each individual case. The amount of anaesthetic inhaled is absolutely under your own control. More than this, when the patient is anaesthetized, the somnoform can be shut in, its escape prevented, and again turned on at the desired time. I have fractured a 5 c. c. tube of som- noform in my Stark appliance, and thirty minutes later found sufficient remaining in the bag to anaesthetize a patient. On the back of the perpendicular tube is soldered a smaller brass tube just the size to hold a 5 c. c. capsule of somnoform. Of course, if it holds a 5„ it will, also hold a 3 c. c. capsule, but not at the same time. The capsule in position,. the cover, another brass tube tele- scopes over the capsule, and when the patient is ready, slight pressure on the telescoping tube fractures the capsule and the contents collect on the absorbent lint, or surgeon's gauze, in a receptacle beneath made for the purpose. A rubber bag is attached to the lower part of the appliance to prevent the somnoform escap- ing after being liberated from its capsule. A special appliance is necessary for somnoform on account of its volatile nature. After once leaving its capsule, it evaporates so rapidly that it is impossible to confine it in any appliance without a rubber bag. On one occasion I went with an oculist to the residence of a patient to administer somnoform for an eye enu- cleation. Upon arriving, I discovered that I had failed to bring the rubber bag. We tried first, holding a nap- kin over the bottom of the appliance where the bag is General AiKrsthetics in Dentistry. 191 attached and wasted four or five 5 c. c. capsules. Then we tried cotton underneath and a napkin over that and wasted two or three more 5"s and gave up in disgust. The next day we returned and with one 3 c. c. capsule inckiced an anaesthesia sufficient for the enucleation, and, when the jjalient returned to consciousness the handagc was in i)osition, the last pin just being inserted. Ethyl chloride can be administered without a bag; so can ethyl bromide, but sonmoform must be con- tained. If you will take a 3 c. c. capsule of somnoform and hold it a little higher than the head and fracture the point by striking it, the fluid will not hit the floorj it will vaporize before it gets that far. The DeFord Somnoform Appliance. The DeFord Somnoform Appliance is a modification of and an improvement on the Stark Inhaler. It pro- vides a means of continuing somnoform inhalation after the patient is ready to be operated on in opera- tions in and about the mouth, nose and eyes. In all such operation the Stark inhaler must be removed from the face when the surgeon begins to operate, but the DeFord Appliance makes it po^siMeCto induce con- tinuous anesthesia while operating, as is done under nitrous oxid and oxygen anaesthesia." Provision is also made to continue the somnoform anaesthesia if desired by the use of ether or chloroform without removing the appliance from its position cm the face. The appliance is strapped on the head in the same manner as a nasal inhaler for nitrous oxid and oxv- 192 General AuccstJietics in Dentistry. gen. By means of a metal rod a mouth piece is at- tached to the nasal inhaler. With the mouth propped open wide, the mouth cover is adjusted in proper rela- tion to the nasal inhaler, covering the mouth, and fas- NASAL INHALER SPONGE RUBBER /SUP^'NT CONNECTION ADAPTER ^BU^ttmkOR SOMNOFORM VALVE FLAT SPRING SUPPORTING TUBE ANESTHESIA INDUCTION— DeFOKD SO.MNOFORxM APPARATUS. teucd tight to the rcjd l)y a set screw. When the pa- tient is anaesthetized the mouth cover is everted and is held up out of the way of the operator by a holding device attached to the nasal piece. If patient shows M ^rf General AiKrsthetics in Dentistry. 193 signs of regaining consciousness, this mouth cover can be dropped into its former position over the mouth, excluding the air, and only two or three inhalations are necessary to reinduce anaesthesia. On top and a little to one side is an exhalation valve. By a half turn of the thumb and tinger this valve can easily be opened or closed. When open the exhalation of the patient escapes; when closed it aids in rebreathing. A soft rubber rim is attached to the nasal piece, making a closer face adaptation and the appliance more comfortable. On the sides are metal buttons for the attachment of a strap or elastic for fastening the appliance to the head. This part of the appliance is identical with the DeFord Nitrous Oxid Inhaler. At the place where the rubber tubing would be at- tached to the inhaler, if nitrous oxid was going to be used, is fastened a metal tube in which is soldered a valve for regulating the amount of anaesthetic and amount of air. This valve is in plain sight of the oper- ator so he can see at all times the adjustment, whether the operation be that of extracting or sensitive cavity preparation. A\'hen the mouth cover is everted no matter what may be the operation, somnoform can be inhaled all during the operation through the nasal in- haler. Breathing once established through the nose is apt to continue after the mouth cover is everted. If this should not maintain anaesthesia sufficiently pro- found, drop the mouth cover as occasion demands. A rubber tube leads from the valve to the break- ing device. The tubing passes up over the head and the rubber bag hangs down back of the head out 194 General Anccsthetics in Dentistry. of the way of the hand of the patient if he should attempt to grab the bag. A somnoform capsule is placed in the breaking de- vice and fractured by pressing the telescoping top. Gauze or cotton is placed in the anaesthetic chamber which takes up the liberated somnoform. In this breaking device can be dropped ether or chloroform to be used in connection with somnoform, or used in se- quence. On the bottom of the anaesthetic chamber is fastened a rubber bag for confining the anaesthetic vapors. For operations on teeth other than extracting, the rubber dam being adjusted, the mouth cover can be instantanously removed, simply sliding over a metal pin to the left. When rubber dam is not used, the mouth cover can be retained in position and dropped down over the mouth for an inhalation or two, as needed. General Anccsthctics hi Dentistry. 195 LECTURE XVI. Somnoform — Continued. Other things being equal, the anaesthetic that dis- turbs physiological functions the least must be a desir- able anaesthetic. The anaesthetic agent that maintains the pulse rate near the normal, that interferes but slightly with respiration, that does not accumulate in the system, that does not alter the secretions of the kidneys, that does not change the blood chemically, that seldom nauseates, is rarely followed by headache or unpleasant after-results, and, in addition," one that quickly anaesthetizes and is quickly eliminated and not difficult to administer is, indeed, an anaesthetic worthy of investigation. Such an anaesthetic is somnoform. A patient about to be anaesthetized, no matter how trivial the operation, or how safe the anaesthetic agent employed, is more or less nervous and excited. It is seldom that a patient takes the dental chair to be anaes- thetized that he does not have an accelerated pulse. Physicians, accompanying patients to. my office to wit- ness an extraction under somnoform anaesthesia, have frequently called attention to the fact that a pulse of 150 or higher, at the beginning of the administration, falls to about 80 or 85 and is maintained at that during the operation. In other patients, the pulse may not beat 196 General Anccstheiics in Dentistry. more than 90 per minute upon taking the chair, but usually quiets down to a little above normal. While somnoform, no doubt, increases the heart's action at the beginning of the anaesthesia, I am inclined to be- lieve that a pronounced acceleration is the result of nervousness and anxiety on the part of the patient. It is no unusual occurrence for the pulse to increase its action perceptibly and sometimes disastrously during an examination for life insurance, even w^hen no heart abnormality is present. There are a few patients who maintain their ner- vous equilibrium to such a degree as not to show ex- citement when about to be anaesthetized. The pulse, in these exceptional cases, under somnoform, in the be- ginning, is usually augmented ten to fifteen beats per minute, but when completely anaesthetized resumes the normal, or just a little above the normal. My experience with somnoform has shown the pulse to be more of an ether than a chloroform pulse; full, bounding and regular. Somnoform- is eliminated quickly, the patient being slightly stimulated, wonder- fully pleased, talkative and buoyant. Even quiet peo- ple talk fluently, and talkative patients for several min- utes will repeat time and again their dream or experi- ence during anaesthesia, amazed and delighted at the result obtained. I recall the case of an attorney for whom I extracted a third molar. He was a large man, weighing, I should say, more than two hundred and fifty pounds. I operated for this man at about 11 A. M., and I never had a more pleased patient in ^my life. About 1 o'clock, he returned to the office and said : General Aiucsthetics in Dentistry. 197 "I wish again lo thank you for the operation you made for me this morning, and I wish that you would show me that appliance ; I want to know just how it works." This is only one instance of the appreciation shown by nearly everyone for whom I have operated under som- noform. I think I may safely say that ninety-five per cent, of the patients to whom I have administered somnoform regain consciousness in a state of com- fortable or joyous stimulation. They can not thank you often enough and they volunteer to send all their friends and neighbors. I recall a fine old gentleman past seventy-five years of age. I extracted seven teeth for him under somnoform anaesthesia, and he ran his hand into his pocket and paid the fee before he left the chair. He remarked that his daughter had suffered for years with her teeth, and he would have her pay me a visit. The next day she arrived. She remarked, "Father drove home from your ofBce, alone, thirteen miles, after you operated for him, put his horse in the stable and came direct to my home, before going into his house, to tell me about it" — another example of somnoform stimulation. Rarely does anyone become exhausted unless ovor- ansesthetized, as the result of somnoform anaesthesia. I have had, perhaps, a dozen cases in which I allowed the patient to rest a few minutes before leaving tiie office. In each of these cases, I administered more somnoform than necessary, or the patient was more thaia ordinarily susceptible to its influence. The respiration at the beginning of somnoform in- duction is usually what the anaesthetist makes it. By J.98 General Anccsthetics in Dentistry. this I mean that the patient tries to breathe as in- structed. I say nothing about the breathing vmtil I ascertain by observation the respiration of the patient. Very seldom is it necessary to make any suggestion in regard to respiration. By giving directions in ad- vance, the patient becomes confused and alarmed and breathes every way but the way you desire. Sa}^ noth- ing and you will succeed far better than by giving the minutest instruction. Ordinary respiration is sufficient to oxygenate the blood, and ordinary respiration is sufficient to somno- form the blood. After the appliance is adjusted, if the patient continues to breathe normally, in a few seconds the respiration will become deeper and slower. Should this occur there is no need for alarm, it is physiological with somnoform. Should the patient after the first few inhalations begin to take shorter and shorter breaths, amounting almost to "panting," in a low, firm voice suggest deeper breathing. If short respiration is con- tinued, remove the inhaler, or shut ofif all somnoform until normal breathing is resumed. With the kind of breathing described, the patient is more apt to become asphyxiated than anaesthetized, no matter what anaes- thetic agent is employed. When I procured my first somnoform appliance, I studied the directions for three weeks before making an administration. My first patient was an athletic young fellow, a foot-ball player, who, in a practice game, fractured his left central and lateral incisors, the pulps remaining in position. The directions that came with the somnoform appliance, said, "Instruct the patient to General Anoesthetics in Dentistry. 199 breathe deeply, and when the first exhalation passes into the rubber bag, break the capsule and exclude all air." As I had administered nitrous oxid for more than twenty years, I thought I knew what deep breathing meant, so I showed my patient in advance how 1 wished him to breathe. He did just as I told him. The first inhalation he received all air, and no anaes- thetic ; on the second inhalation the air was excluded from the appliance and he received all somnoform with the air he had exhaled into the bag. His head fell to one side like he had been hit with a black-jack. I re- moved the pulps and then took out my watch and timed him. His pulse was strong, his respiration a lit- tle deeper than normal, and he slept as quietly and as peacefully as a child for the period of six minutes. The same afternoon a girl, fourteen years of age, pre- sented with the lower sixth year molars on each side broken down. I instructed her to breathe about half as deeply as the young man, and allowed her to take three inhalations with all air excluded, extracted the teeth and could have removed others. After a while I learned that deep breathing was not essential to som- noform anaesthesia, and at the present time, as inti- mated above, prefer normal breathing in nearly all cases. Occasionally a nervous child or a hysterical woman, at the very beginning of sonmoform induction, will hold their breath and refuse to breathe. The longer the breath is lield, the deeper will be the next inhala- tion. It is important just here to watch closely. The inhaler should be removed or the vahc closed, pre- 200 General Anesthetics in Dentistry. venting the somnoform from escaping, as it would be dangerous to inhale pure somnoform at the next in- halation. You will recall that many patients die when chloroform is administered when only two or three inhalations have been taken. The vapor was too strong or the inhalations too deep. It is evident that somnoform does not accumulate in the system, because the patient recovers consciousness very quickly no matter how long the anaesthetic state is maintained. My longest somnoform anaesthesia lasted twenty-five minutes, and in a minute after re- moving the inhaler the patient was wide awake. This was a case of crushed fingers. The surgeon thought five minutes would be ample for the operation, but the case proved to be more complicated than at first sup- posed. At the end of five minutes I suggested ether, or chloroform, but there was neither in the office of the physician, and the operation would have been discon- tinued if either of us went to a drug-store, so there was nothing to do but continue with somnoform. I used ten 5 c. c. tubes, and the patient left the office in less than three minutes after the anaesthetic was discon- tinued. Dr. Bronson, a dentist residing at Gowrie, Iowa, told me that he anaesthetized his sister-in-law with somnoform for a surgical operation, and maintained surgical anaesthesia for thirty-five minutes. I had an opportunity to talk with the patient and had her give me a history of the case. She had, on previous occa- sions, been anaesthetized with both ether and chloro- form and was in a position to make a comparison. She General Anasthetics in Dentistry. 201 informed me that the somnoform anaesthesia was in no way unpleasant and that she awoke just as she did mornings from natural sleep. She felt no pain what- ever during the operation. There was no nausea, such as she had experienced with ether and chloroform. The anaesthetist told me he had hardly removed the inhaler when she was wide awake. 1 mention these cases to show that somnoform is not cumulative in the sense that ether and chloroform are cumulative. 1 have had brought to my notice a few cases where patients were drowsy and wanted to sleep after the operation. This is common to chloroform and ether, but seldom occurs as a sequence to nitrous oxid and somnoform. Hewitt, however, mentions a case, reported to him by a physi- cian, of a patient who slept for three days after an anaesthesia induced by nitrous oxid gas. Dudley Buxton, the English anaesthetist, says, "Dr. Swain has examined the blood of patients before and after taking somnoform and found no change in the amount of haemoglobin or in the number of leucocytes. Urinary analyses have been made prior to and at the conclusion of somnoform anaesthesia and no alter- ation in the specific gravity or nature of the urine has been observed. [Buxton.] Somnoform, so far as I have been able to observe, does not irritate the mucous membrane; nor does it irritate the nerves of the nares, pharynx, larynx, tra- chea, bronchi or lungs. Its non-irritability is an ele- ment of safety well worth mentioning. From the fact that it does not irritate the mucous membrane, there is an absence of accumulation of mucus in the throat. 202 • General Anccsthetics in Dentistry. such as we always have accompanying the administra- tion of ether. This mucus sometimes almost defeats surgical anaesthesia, and the anaesthetist must discon- tinue frequently and swab out the throat to prevent suffocation. From the fact that somnoform does not irritate the nerves, we can almost eliminate the condition known as Laryngo Reflex, "Syncope of Duret." Irritating anaesthetic vapors sometimes reflexly cause paralysis of the respiration and circulation, which has already been considered in a previous lecture under "Spasm of the Glottis." From the fact that somnoform is non-irritating to the respiratory apparatus, it is indicated especially in minor surgical operations, and for all patients afflicted with pulmonary disorders. Nitrous oxid causes enlargement of the tongue and the soft tissues of the pharynx and throat from venous engorgement. Patients having hypertrophied tonsils, adenoid vegetations in the upper pharynx, en- larged or oedematous uvula or abnormal growths or neoplasms of the throat are far more comfortably anaes- thetized with somnoform than nitrous oxid. Nitrous oxid increases the size of all these tissues, already ab- normally enlarged, while there is no change in the size of the tissues or organs named when somnoform is the anaesthetic agent used. Nausea is not a very common occurrence during or following somnoform auccsthesia. Rolland claims but one per cent, of nausea. 1 can well understand why some anaesthetists have General Anccsthctics in Dentistry. 303 more nausea than others. Nausea depends mostly on three conditions : First, administering an auccsthetic on a full stomach, or too soon after eating. This cause I will eliminate, because, as dental surgeons operate largely for patients under nitrous oxid and somnoforni just when they happen to come to the office, one den- tist is as apt to get patients of this kind as an()2-304 Soninoform 199 Sylvester artificial 299-300-302 Kesuscitation — Methods of 298-299-300-301-302-304 ElCHARDSON 32 EOLLAND 14-179 schofield 54 Shock — Causes of 22 51 -55-63 Circulatory 50 Classification of 51 Composite 50 Deaths from , 52-53-101 Definition of 50-51 Psychical elements in 51 Respiratory 50 SOMNOFORM — Administration of 207-210 Air in administration of 210 Alcoholics under 214-228-229 Analgesia with 225-232 Dreams under 221 Extraction under 212 213 Inhaler, DeFord 192-lfl2A Inhaler, Stark 188-189 Mucous membrane, effect on 202 Nausea 1 82-202-203-20(5-216 Neurotics in 176 Operations 233 Over-ana>sthization .203-218 Period available 181 Plethorics under 210-213 Respiration in 199 Safety of 182 Spasm — Causes 61 Clonic 133-144 Conjunctival reflex 130-133 Deaths due to 96 Effects duriufj ana'sthesia 60 Larvngial reflex 202 Of irlottis 59 Simpson, Sir .Tames Y 56-270 Stertorous BuEATiiiNr, 131 Success — Elements of '^9 SUOGESTION — As an aid in inducing anspsthesia 82-268 Teter, Ciias. K 98-107-147-162 313 Index. Thorpe, Burtox Lee 104-106 Wells, Horace — Portrait, frontispiece 14-1U4-106 Women — As ana?sthetists 46 Clothing, arrangement of, for antesthesia .59-279-304 Date Due M II ^ iKIh^ -Apr 2 8 1941 ■ f) J