HXOOO 15067 Columbia ®ntoersttp x ^ fa tfje City of Jleto govk COLLEGE OF PHYSICIANS AND SURGEONS Reference Library Given by ^v Yv. ^ -S •^ c CONSTITUTION, BY-LAWS, OFFICERS and LIST of MEMBERS of the SOCIETY of ALUMNI of ^BELLEVUE HOSPITAL 1913 NEW YORK 3nbex Frontispiece "Bellevue as Proposed" 3 Officers and Standing Committees for 1913 4 Officers and Standing Committees for 1914-15 5 Bellevue Chronicles 6 President's Inaugural Address 18 Obituary: J. O. Pingry, J. E. Allen, E. S. Bogert 33 I. W. Condict, M. Thomson, W. S. Cheesman 34 H. J. Owen, J. C. Young, F. Hartley 35 R. L. Brodie, C. McBurney 36 C. Phelps 37 Death Roll 38 Programs 45 Prize Essay 51 Constitution and By-Laws 69 Roster : Resident Active Members 87 Non-Resident Active Members ( 99 Emeritus Members 104 Permanent Associate Members 105 Non-Resident Permanent Associate Members 105 Honorary Members 105 Associate Members ; 106 Statistics 107 Officers : Presidents 108 Vice-Presidents 109 Secretaries 110 Treasurers 110 Historian 110 Founders Ill Digitized by the Internet Archive in 2010 with funding from Open Knowledge Commons http://www.archive.org/details/constitutionbyla1913newy E/O.ST- • BlvtB • FlCiT AvtNut •• 0^ •• 5lock • Plam •- □ COMrl»T» MtLOlMb NtW btLUtVUt . Hoft'lTAt • NtW YoBn ClT)'. 56Mtl-lH W S Ph O ffi to O o ON CO CM~ o o o CM CM ON CM 00 CM 1— 1 On CO On On vO CM ir> CO CM c o CQ a o rt C to o to cc o 00 00 VI- o c a "c5 to -Program* 45 programs October 4th, 1911. Installation of the President-Elect and of the Standing Com- mittees. Floyd M. Crandall, M.D. President's Address. H. Seymour Houghton, M.D. Discussion on the Work of the Society. Joseph D. Bryant, M.D. November 1st, 1911. Resolutions upon the death of Starling Loving, M.D. and Stephen Pierson, M.D. Report on Fulguration of papillary growths of the bladder, with presentation of patients (7 cases.) J. F. McCarthy, M.D. The Paper of the Evening: Cardiospasm: Its general considerations. John E. Erdmann, M.D. December 6th, 1911. The Paper of the Evening: Some Recent Advances in Sewage Disposal. Clyde Potts, C. E. ; M. Am. Soc. C. E. (by invitation.) January 3rd, 1912. Presentation of a Case of Thoracic Aneurism Treated with Gold Wire and Galvanism. W. C. Lusk, M.D. Paper: Local Anesthesia in Major Surgery. A. S. Morrow, M.D. The Paper of the Evening: The Neurologist and the Surgeon. Robert T. Morris, M.D. 46 programs February 7th, 1912. The Paper of the Evening: Post-operative Gastro-Enteric Paresis, with Cinematograph Demonstration of the Action of Drugs on the Peristaltic Movements of the Intestines. James Taft Pilcher, M.D. March 6th, 1912. Paper: The Significance of an Acid Gastric Juice in the Fasting Stomach. Harold Barclay, M.D. The Paper of the Evening: Operative and Post-operative Treatment of Appendicitus. Parker Syms, M.D. April 3rd, 1912. Paper: Clinical Observations on Morphinism and its Treatment. Ernest S. Bishop, M.D. A Consideration of Gas Bacillus Infections with Special Refer- ence to Treatment. Walter C. Cramp, M.D. May 1st, 1912. Paper: {A.) Management of Occiput Posterior. Frederick W. Rice, M.D. Paper: (B.) The Treatment of Eclampsia. Harold C. Bailey, M.D. May 29th, 1912. Presentation of Cases: I. a. Cerebro-Spinal Syphilis. b. Charcot Joint. Clarence G. Bandler, M.D. II. c. A Case of Elephantiasis. b. A Case of Extrophy. J. F. McCarthy, M.D. programs! 47 III. Paper: Vesical Neoplasms. Their Diagnosis and Treat- ment. (Lantern Slide Demonstration.) J. F. McCarthy, M.D. October 2nd, 1912. The Paper of the Evening: Mechanism of Narcotic Addiction. Emest g Bishop> M D November 6th, 1912. Presentation of Patients. Case of Restoration of Entire Nose by Rhinoplasty and Bone Transplantation. W. W. Carter, M.D. Paper: Artificial Feeding of Infants. Ward Bryant Hoag, M.D. - December 4th, 1912. Paper: Preserving the Sphincters in the Treatment of Fissure and Fistula. Gustavus A. Humphreys, M.D. January 8th, 1913. Installation of the President-El ect and of the Standing Com- mittees. H. Seymour Houghton, M.D. President's Address. Henry Mann Silver, M.D. Paper: The Control and Prevention of Compensation in Cardiac Disease, with Lantern Demonstrations. Charles E. Quimby, M.D. February Sth, 1913. A Contribution to the Etiology of Pernicious Anaemia. James T. Pilcher, M.D. Paper: Later Notes on the Subject of Loose Kidney. Robert T. Morris, M.D. 48 -program? March 5th, 1913. Report of a Case of Syphilis of the Eye. J. H. Woodward, M.D. Paper: Consideration and Treatment of Malignant Conditions of the Colon. John F. Erdmann, M.D. Pathology and Laboratory Aids in Diagnosis of Malignant Conditions of the Colon. Frederic E'. Sondeon, M.D. (by invitation.) Lantern Illustration: Radiographic Indications of Colonic Ob- struction and Points of Differentiation between Malignant and Non-malignant Lesions. Lewis Gregory Cole, M.D. (by invitation.) April 2nd, 1913. Clinical Meeting held at Bellevue Hospital. I. Presentation of New Instruments. a. An Improved Aspirating Endoscope for Bladder and Deep Urethra. b. An Improved Prismatic Cystoscope and Deep Urethro- scope. Demonstration of Use of Above Instruments to Small Groups in a Side Room. Joseph Francis McCarthy, M.D. 11. Presentation of Patients. a. Medical Divisions. Edmund Le Roy Dow, M.D. W. Gilman Thompson, M.D. Samuel Albertus Brown, M.D. Alexander Lambert, M.D. b. Pediatric Division. Linnaeus Edford La Fetra, M.D. (by invitation . ) c. Surgical Divisions. Lucius Wales Hotchkiss, M.D. George Woolsey, M.D. George David Stewart, M.D. Howard Lilienthal, M.D. (by invitation.) programs 49 III. The Roll of the Roentgen Examination in the Diagnosis of Obscure Conditions. Isaac Seth Hirsch, M.D. (by invitation.) May 14th, 1913. Paper: The Freudian Conception of the Psychoneuroses. Horace Westake Frink, M.D. The Technique of Psychoanalysis. Clarence Paul Oberndorf, M.D. June 4th, 1913. Paper: Oedema in Infants not due to Nephritis. Henry Dwight Chapin, M.D. Meningitis and Meningismus in Pneumonia of Children. Francis Huber, M.D. October 1st, 1913. Paper: Joint Symptoms Following the Use of Serum Therapy. Wisner R. Townsend, M.D. The Importance of Early Diagnosis in the Prevention of De- formity in Joint Disease. Reginald H. Sayre, M.D. Reading of the Annual Prize Essay— "The Acidosis Index. A Method of Determination for the Use of the General Practi- tioner, by Means of a Universal Colorimeter." November Sth, 1913. Clinical Meeting held at Bellevue Hospital. 1st Medical Division. Frank Erdwurm, M.D. o. Demonstration of Artificial Pneumothorax by Filling the Pleural Cavity with Nitrogen Gas. b. Lantern Exhibition of X-Ray Slides of Filled Chests. 4th Medical Division. Chas. E. Nammack, M.D. o. Progressive Muscular Dystrophy. b. Syringomyelia Morvan's Type. 50 programs! Poycopathic Division. M. S. Gregory, M.D. (by invitation.) a. Depression (Maniac-Depressive Psychosis) in a Child of Ten Years with Some Remarks on the Psychoses of Childhood. b. Tabes Dorsalis, with Superimposed Melancholia: Fre- quently Mistaken for General Paralysis. 1st Surgical Division. John B. Walker, M.D. a. Localization of Foreign Bodies by Surface Markings. b. Pansinusities of Nasal Sinuses. c. Old Outward Dislocation of Elbow. d. Operation for Old Fracture of Oscalcis. 2nd Surgical Division. John A. Hartwell, M.D. a. Jejunal Ulcer: Secondary to Gastroenterostomy. b. Epithelioma of the Tongue. Roentgen Ray Department T. S. Hirsch, M.D. (by invitation.) The Roentgen Ray Diagnosis of Oesophageal Diseases. December 3rd, 1913. 1st Paper. Julius H. Woodward, M.D. Ophthalmological Signs of Posterior Spinal Schlerosis. 2nd Paper. Robert T. Morris, M.D. Adventitious Tissues in the Peritoneal Cavity. $rt?e Cstfap 5 1 THE ACIDOSIS INDEX. (Awarded the Annual Prize for 1913) A Method of Determination, for the Use of the General Practitioner by Means of a Universal Colorimeter. "There is nothing truly valuable which can be purchased without pain and labor." — Tattler If we were to chose a text for this paper, we probably could do no better than to quote a sentence from Sir William Osier's introduction to his Modern Medicine, as it has in it the very essence of what I have tried to bring out in the first few pages to follow. Under the heading, "The Evolution of Internal Medicine," he says, "Just as the clinical laboratory is a necessity to the hospital physician engaged in the solution of the most advanced problems in medicine, so the private laboratory is in- dispensable in the every-day work of the busy practi- tioner." Once having been wedded to the laboratory in our hospital work, the partnership becomes vitally es- sential, and ignorance alone can make us insensible to its loss. Knowing that instances of cure are exceedingly rare in certain chronic diseases, in many cases the general practi- tioner takes the attitude of sympathetic tolerance and indifference, dismissing his patient with a few text-book directions on diet and hygiene, and with orders to report at irregular intervals with a specimen of urine for routine qualitative analysis. Losing sight of the pos- sibility of prolonging life, looking only at the ultimate outcome, how many of us turn our attentions to the acute illnesses of known etiology, preferring to consider the more obscure chronic conditions as playthings of extreme interest to the detail laboratory man and physiologic 52 $ri?e €a£ap \- : chemist, but as far too complex and hopeless for us who dub ourselves practical men. We have allowed ourselves to become confused in the entangled maze of experi- mental reports constantly appearing in our journals; we have turned back when confronted by bewildering organic formulae and theories of pathological metabolism, and have left to the well equipped laboratories the long, careful quantative estimations, so helpful in following the progress of our case. As a result, in general practice the chronic case is usually avoided, treated indifferently, or sent to a hospital where responsibility may be shifted on to the hospital staff. But can the responsibility be shifted? In summing up the few cases of diabetes mellitus that I have had opportunity to work over, the hospital histories may be generalized somewhat as follows : At the advice of his physician, patient A enters the hospital with well marked signs and symptoms of diabetes mellitus. Previous records often show that he has been at some hospital at some previous date for treatment of the same condition. Enthusiastic members of the hospital staff, after careful labora- tory estimations, place the patient on a diet which is checked by laboratory reports. Every detail is carefully worked out. Improvement probably takes place, when, suddenly, the patient decides to leave. He may object to the treatment, it may be a question of time or expense, the fact remains, however, the patient leaves. All the careful work, the elaborate charts, the painstaking feeding, as far as the patient goes, is probably for naught, for he immediately goes on a carbohydrate debauch and sooner or later seeks his family physician in about the same condition as when he entered the hospital. The responsibility, therefore, returns to the general practitioner, and it is for him to regulate the life of this man who refuses to spend the remainder of his days in the wards of a hospital. Diabetes mellitus is a striking example of that type of disease which can be made to pause in its relentless march by proper treatment, and the end postponed for months and at times for years. Considerable advance has been made of late concerning its causes and we have developed a method of feeding whereby we can to a certain degree control the sugar output and influence the acidosis, there- by prolonging the life of the individual. However, the influence of a strict diet may be decidedly detrimental, and tend only to hasten the fatal termination. Without a laboratory check, therefore, we group as one in the dark and often find the dreaded Coma the only reward for our efforts. Coma, particularly in the young, is the termination in a considerable proportion of the cases of diabetes mellitus, coming on sometimes slowly, sometimes swiftly, but never unannounced to him who is watching for it. Naunyn reports nineteen cases of Coma out of forty-four fatal cases of diabetes mellitus ; Frerichs reports one hundred and fifty out of two hundred and fifty fatal cases; Taylor, twenty-six out of forty-three; Mackenzie, nineteen out of eighty-seven ; Williamson, twenty-eight out of forty. (Osier.) Von Norden, in "Newer Aspects of Diabetes" says, "the observation that diabetic Coma is coincident with excretion of large quantities of acetone bodies has lead us to consider the acetone bodies the most dangerous enemies of diabetics." "Coma," the manifestation of a profound intoxication, "is an almost hopeless complica- tion." (Osier.) Since Coma spells the end in so many of our diabetic cases, since it is not only coincident with, 54 $ri^ Cssap but also preceded by acidosis, is it not important, then, that the estimation of the degree of acidosis be made when by this method we can anticipate Coma and thus prolong a possible useful life by proper treatment? The presence of Beta-oxybutyric acid and diacetic acid is usually of serious import, but in a great many cases diacetic acid may be present for months with apparently no serious consequences. A case in Dr. Alexander Lambert's wards at Bellevue Hospital, while I was intern, was a striking example of this condition. The patient, Case I, was sent into Ward B 3 by an outside physician with a history of long standing diabetes mellitus. On admission, sugar and acetone bodies were found present in large quantities in his urine. Under treatment, the patient gained weight, constitutional symptoms disappeared, but despite every effort tests for acetone and diacetic acid were always strongly positive. Finally the patient left, much improved but with sugar and diacetic acid still present in his urine. The diabetic, therefore, develops what may be termed an "acidosis tolerance" within the limits of which he may improve and enjoy life. As this degree of tolerance varies with the individual, it is quite important then that the danger point be ascertained in order that the physi- cian may know just where his patient stands as regards acidosis tolerance, and be ready to treat any increase without forcing the patient needlessly to undergo treat- ment for acidosis when he is within his limit of tolerance. Again, knowing the limit of tolerance, how readily can the effect of a change of diet or medication on the acidosis be noted and how quickly can the error be remedied if such a change tends to increase the acidosis? 3$vi}t Cssap 55 That, during change of diet or medication, the patient should be carefully watched as regards his acidosis, is emphasized by the following case : Case II entered Ward A 2 about the same time that Case I, referred to, was under observation. He also had a typical diabetic history, and, on admission, was excreting acetone bodies in large amounts. Under careful dieting the patient gained weight, constitutional symptoms disappeared, and he was thinking seriously of leaving the hospital. His urine, during the several weeks he was under observation, showed the persistent presence of acetone bodies. At this time I attempted to follow out Hart's method of quantative estimation of diacetic acid with a modi- fied apparatus, but because of an error in the original article the standard solution did not give the required color reaction. An attempt to reduce the sugar present by giving the patient Fowler's solution, as suggested in Forcheimer's treatment, resulted in a rapid increased acidosis, Coma and death. If, when the treatment with Fowler's Solution was begun, a simple method of measuring the increased acidosis had been at hand I feel confident that we could have stopped the treatment in time to prevent the Coma, provided that we had known the patient's acidosis tolerance from previous observations. Granted that the responsibility for the welfare of the diabetic rests largely with the general practitioner, that in the estimation of the acidosis index he has a method of anticipating approaching Coma, and that by anticipat- ing Coma he can prolong his patient's life in many cases, the only conclusion that can be drawn is that the general practitioner must, in order to conscientiously follow his patient, estimate at frequent intervals the acidosis index, 56 $kt?e Cstfap daily estimations being necessary when the acidosis toler- ance is exceeded, when changes in diet or medication are being made, or while the patient is suffering from some acute illness. If the busy practitioner is to determine the acidosis index, how shall he do it? Glancing over the various methods for the quantitative determination of the acitone bodies in urine, we find several among which are (1) the quantitative estimation of the bases and inorganic acids; (2) the direct estimation of acetone and diacetic acid by Messenger's method; (3) the polariscopic method; and (4) the estimation of the increased amount of ammonia. The same objections, in the main, apply to all these methods; they take time, special skill, and complex apparatus. The ammonia determination is used more frequently than the other methods but is subject to many errors, and cannot be used when the patient is taking alkalies. So, if quantitative laboratory estima- tions are to become popular, methods must be devised that are simple, inexpensive, and time saving. In the Esbach albuminometer we have such an apparatus and since its advent puerperal toxaemia has been carefully and scientifically treated by all conscientious physicians, and the course of an acute nephritis intelligently follow- ed. If the quantitative estimation of albumen has aided the general practitioner in anticipating approaching eclampsia, why should not the estimation of the acidosis index be placed on a similar footing in the anticipation of diabetic Coma? The answer to this question is that there is no efficient popular method by which this can be done. T. Stewart Hart, in the Archives of Internal Medicine, Vol. VII, described a method by which he could roughly compare the color of urine treated with ferric chloride. The principle was one of dilution, similar to that used by Gower in his Haemoglolinometer. This method, with a modified apparatus, referred to under Case II, although proving unsuccessful at the time the article appeared because of a publisher's error, made us realize how helpful a simple method for determining the quantative diacetic acid output would be. With these initial attempts in mind I have since been working on such a method, and have produced something, I think, that will be very helpful to the profession at large, not only in cases of acidosis but in all cases where color comparisons can be used in quantitative estimations. The method is particularly useful in the determination of the acidosis index and in the functional kidney tests where dyes are used. In approaching the problem of a colorimeter, substances for standards must be found which give the correct color, and, if the color is not lasting, a method must be developed which takes this into consideration. Many colors in solution slowly fade. Phenol-Sulphone-Patha- lein is an example. Serial dilutions of this substance show color changes after one or two months which are sufficient to make the standard unreliable. Fixed colors are difficult to match if made from substances differing from the substance to be tested for. Using the well known Gerhart's Ferric Chloride test for diacetic acid as the foundation of the work, a colori- meter has been developed which, I think, will fulfill the previously stated requirements. The Standard Solutions. Solution I. A great many substances react with ferric chloride resulting in color changes. These must be thought of in using the Gerhart Test for diacetic acid. Salicilic acid and other salicilates (diuretin, asperin, 58 $rt?e Csstap etc.) give a color reaction with ferric chloride similar to but more bluish than the diacetic reaction, the blue deepening as the strength of the salicilate is increased. Sodium acetate has more of the red to its reaction, quite evident in the stronger solutions. The ester of diacetic (aceto acetic) acid, aceto acetis ester, gives an exact color for comparison and this reagent was chosen for the standard. After working with aceto acetic ester I found in later numbers of the Archives of Internal Medicine, the correction of Hart's original article, and the corrected reagent was stated as ethyl aceto acetate, which is equivalent to my aceto acetic ester. Aceto acetic ester is stable, gives the typical Bordeaux red color with ferric chloride, and is cheap, being listed in Merck's cata- logue at sixty cents an ounce, obtainable through the New York office. It is a clear, colorless liquid, rather oily in consistency, and with a distinct fruity odor. One c. c. disolves quite readily in 1000 c. c. of water when shaken up well. This 1 to 1000 solution is used as Solution I. Solution II. A given number of grams of the solid ferric chloride dissolved in an equal number of c. c. of water makes a concentrated solution which, when added to solution I, drop by drop, gives the maximum 1 color without causing an appreciable dilution, as weaker solutions would. Dilution of the specimen is to be avoided. In experimenting with Gerhart's method the following observations were made : (1) The maximum intensity of color is not reached immediately but gradually over a period of half a minute or so in the case of the aceto acetic $rt?e €&$ap 59 ester solution. The ferric chloride, therefore, should be added drop by drop, stirring the solution until the color reaches its height. This is important. If too little ferric chloride is added the color is less than it should be, and if too much be added the standard is diluted and takes a little of the brownish hue of the ferric chloride. (2) The color resulting from the reaction gradu- ally fades. In a series of dilution varying fro 1% to .1% changes were noted in the weaker solutions in two weeks, the change continuing until the color was completely gone in the 1% solution. Addition of ferric chloride to the stronger solution caused a return in part of the color, but the weaker solutions remained colorless. (3) Inquiring into the cause of the fading of the color it was found that increasing the acidity of the original solution of aceto acetic ester with con- centrated hydrochloric acid increased the rapidity with which the color faded. A point of acidity was reached where the addition of ferric chloride caused no color change. Testing the ferric chloride it was found acid to litmus. It was concluded then that in the presence of this acid salt the color could not be made to remain permanent. Taking one of the solutions that had been discolorized by the addition of a few drops of hydrochloric acid, by carefully adding a base, like sodium hydroxide, the color returns for a moment but as the base predominates, the iron precipitates as the flocculent hydrate. However, adding to this the ferric chloride solution until the base is completely precipitated as the hydrate, an excess of the ferric chloride at once brings out the color as intense as originally. We 60 $ri?e Caslap conclude from this that the fading of our color is not due to decomposition of the aceto acetic ester alone but that the acid ferric chloride takes part in the reaction. (4) Experimenting with a basic solution of aceto acetic ester, an interesting point was brought out which would apply to urines from patients under alkaline treatment. Until the acidity of the ferric chloride had neutralized the alkalinity of the urine no typical color reaction appeared. Then a large amount of ferric chloride would have to be used in strongly alkaline urines before the neutral point was reached where color changes would begin. This not only wastes reagent, but what is more important, as will be seen later, causes dilution of the specimen, leaving a source of error in the readings to be taken later. Again, in alkaline urines, a thick heavy precipitate of ferric oxide forms on the addition of ferric chloride which, when caught in the effervescence of the escaping carbon dioxide, results in a thick, frothy chocolate colored mixture which, if not impossible to filter, certainly delays that procedure greatly. Fe, CI. -|- 6 (Na HC0 3 )=Fe 2 8 -|- 6 CO* -|- 6 NaCl -|- 3 H2O. This hindrance can be eliminated in the following way. Place a piece of litmus in the alkaline specimen of urine to be tested and add con- centrated hydrochloric acid, drop by drop, until the litmus shows a faint acid reaction. The CO* is eliminated, thus leaving a clear solution. Na HCOe -|- HCl=NaCl -|- PLO -J- CO*. Having eliminated the carbonates with a minimum amount of dilution add the ferric chloride as directed. The only pre- cipitation that forms, if any, will be due to the phos- phates. These are quickly filtered out. $rt*e Cssap 61 (5) Sodium Salicilate, salicilic acid, diuretin, as- perin and the other salicylates in solutions could easily be mistaken for diacetic acid, but when compared side by side, the color of the salicilates is more of a blue than a red, the strong solutions having a deep indigo color. Staubli has shown that in benign cases of acidosis, in spite of a high content of acetone and diacetic acid, the amount of Beta-oxybutyric acid in the urine is small. However, with an increase of Beta-oxybutyric acid, there would necessarily be an increase of diacetic acid; there- fore, knowing the diacetic tolerance, the rise and fall will parallel the rise and fall of the Beta-oxybutyric acid. Hart found in his cases that the measure of the acidosis index, based on the depth of color obtained with the ferric chloride reaction, paralleled the results obtained by the polariscopic method and the ammonia output. The principle of the colorimeter in which our solutions are used is founded on the following physical laws : (1) Media, which we commonly speak of as transparent, if not employed in too great thicknesses, transmit, without appreciable absorption, the range of wave lengths within the region of the visible spectrum. (Physical Optics — Wood.) (2) In the case of most of the absorbing media, the color of the transmitted light does not depend to any degree on the thickness, the depth or satura- tion merely increasing. (Physical Optics — Wood.) The depth or saturation, therefore, the color remain- ing the same, will vary with the thickness, that is, with the number of molicules of the dissolved substance in a given length of the medium transmitting the light. Hence, two media containing the same amount of a given color substance in solution, transmit light of the same 62 3^vi}t CsSap color and the same depth or intensity. The volume remaining the same, the depth or intensity of the color varies with the amount of color substance in solution; or the depth or intensity remaining the same, the volumes vary with the amount of color substance in solution. Through the same distance a 1% solution of a given color transmits light of half the intensity as through a 2% solution of the same color substance ; or to give a color of the same intensity, light must pass through but one half the distance in a 2% solution as in a 1% solution of the same color substance. We have, therefore, simply to arrange an apparatus that will lengthen or shorten a column of liquid in order to increase or decrease at will the intensity of the color, the light being transmitted through the full length of the column. Description of Colorimeter. I. The Containers. Two glass tubes 12 cm. long, and of at least 15/16 inches in diameter. With shorter diameters the light reflected from the sides is confusing. A polished crown-glass base for each tube. Crown-glass transmits a pure ray of white light. The base is ground so as to set into the tube giving a better grib for the cement. Both tubes are graduated in centimeters, beginning at the level of the inner surface of the base, from one to ten inclusive, each centimeter being sub- divided into quarters. II. The Holders and Reflector. Two brass tubes into which each container can slip easily, act as supports and shut out the side lights. The tubes are threaded perpendicularly close together into a common base, the base of each tube being open so as to allow the light to be transmitted $rt?e Cssfap 63 the full length, but with a diameter just small enough to support each container as it is slipped in, thus preventing the container from slipping through. A white enameled reflector at an angle of 45° allows a bright light to enter the base of the tubes and gives a white background for the color. The black lines on the reflector give the observer an object to focus on as at first the different heights of the two columns of liquid may be confusing, and they also help in judging the intensity of the color. III. The pipet is simply a tube 12 cm. or more in length with a small bulb attached. With this the fluid in the tubes can be raised or lowered at will. It is bent at right angles at the 12 cm. point so that bulb will not be in the line of light. Directions for using colorimeter. Take about 40 c.c. of the standard solution I, and add to it, drop by drop, sufficient of the standard solution II to bring about the maximum color, stir- ring solution at least half a minute after last drop, to insure that the reaction has been completed. Fill one of the containers up to the 5 c.c. mark with this solution and place container in the stand, pre- ferably in the left hand tube. Treat the specimen of urine as directed previously with the ferric chloride, sol. II, and filter. A drop more ferric chloride will insure complete reaction. Fill the second container up to the 10 c.c. mark with the filtered specimen and place the container in the right hand tube of the stand. Arrange reflector so as to get the maximum light and compare the intensity of the colors. If the specimen on the right is darker than the standard, draw it off with the pipett until the two match 64 $rt?e €*siap exactly. If the specimen is lighter, lower the standard with the pipett until the two match. Having matched the tubes exactly, take out both containers and read the heights. For convenience we will call the 1 to 1,000 aceto acetic ester solution 1, and make the readings of the diacetic acid in the specimen of urine in terms of the standard, thus the index per thousand c.c. of a specimen whose color, density and height of column in the scale were the same as that of the standard, would be 1. We have, therefore, an inverse proportion between the lengths of the columns of the two solutions on the scales, and the amount of color substance in the solutions, and knowing three of these quantities we can easily find the fourth. If "A" is the height of the standard on the scale, "B" the height of the specimen, "1" the index of the standard and x the index of the specimen, then j • x = B -A The acidosis index per letter then is -g- and for 24 hours -3- multiplied by the letters passed in 24 hours. Hypothetical Case. If patient passes 5 leters in 24 hours, and the height of the standard is 5, and the height of the specimen is 2.5, then x = Y5 — 2. Acidosis index per letter. 5x = 10. Acidosis index per 24 hours. How helpful this method can be to one following a case with acidosis is easily seen, and its simplicity brings it within the reach of all. With such a method the progress of the case can be satisfactorily and $ri?e Csteap 65 scientifically followed, determination being made even while the patient is in the office without waiting for a complicated laboratory report from some distant laboratory. In hospital work, having once been checked up by an ammonia determination, or by one of the other methods, daily estimations may be made by the intern which will be of great help to the visiting staff who know what laboratory delay is where frequent long analyses are called for. The following chart shows the acidosis index of a case of long standing diabetes mellitus, who, under treatment, has gained weight and shows marked improvement. From the time the patient came under observation acetone and diacetic acid have been pres- ent in the urine. The chart shows a probable acido- sis tolerance ranging between 10 and 15 in 24 hours. The fact that it is fairly constant and that the patient is improving shows that no special treatment for the acidosis is necessary. WW --_.fi The colorimeter was developed primarily for work with cases showing diacetic acid in the urine. The prin- 66 $rne CtfSap < - - " - ciple can be applied, however, to any quantitative esti- mation where color comparison is used, provided a suitable standard can be found. In the lunctional kidney tests, using a known dilution of the dye as a standard, the percentage excreted in the urine can easily be deter- mined by this method. Because I have found in my limited experience that this colorimeter has been a great help in certain cases, and because it will fill a place in the laboratory of the general practitioner which has long been neglected, I have taken this opportunity to bring it before the pro- fession, hoping that some, at least, may find it helpful in their work, making the treatment of such cases as diabetes mellitus more scientific and more satisfactory. References T. S. Hart, Archives of Internal Medicine. Vol. I and Vol. VII. R. W. Wood, Optics. E. C. C. Baily, Stectroscopy. Von Norden, Newer Aspects of Diabetes. Osier's Modern Medicine. A. M. MEADS, M. D., Bellevue Hospital, July, 1910-July, 1912. %xm Cstfap 67 CO NT* IN6R. STANO t— , 1— J »-- v P ■fc * * "itt. * E± -w^H^y^\ ^ i*