HV^ Columbia ^mbersiitp inttcCitpof^etogorfe department of ^urgerp ^uU iilemonal Jf unD Digitized by the Internet Archive in 2010 with funding from Open Knowledge Commons http://www.archive.org/details/americantextbookOOkeen AN AMERICAN TEXT-BOOK OF SURGERY, FOR PRACTITIONERS AND STUDENTS. BY PHIXEAS S. CONNER, iM. D., FREDERIC S. DENNIS. M. D., WILLIAM W. KEEN, M. D., CHARLES B. NANCREDE, M. D. ROSWELL PARK, M. D.. LEWIS S. PILCHER, M. D . NICHOLAS SENN, M. D., FRANCIS J. SHEPHERD. M. D., LEWIS A. STIMSON, M. D.. J. COLLINS WARREN, M. D., AND J. WILLIA:\I WHITE. M.D. EDITED BY WILLIAM W. KEEN, M. D., LLD., AND J. WILLIAM WHITE, M. D., Ph.D. THIRD EDITION, THOROUGHLY REVISED. PHILADELPHIA: W. B. SAUNDERS, 925 Walnut Street. 1899. Copyright, 1899, by W. B. SAUNDERS. ELECTROTVPED BY PRESS OF WESTCOTT A THOMSON, PMILAD^ ^, B. SAVNDERS, PHILADA. TO THE MEDICAL PROFESSION AND MEDICAL STUDENTS OF AMERICA THEIR CO-WORKERS AND FELLOW STUDENTS, THE AUTHORS. LIST OF AUTHORS. PHINEAS S. CONNER, M. D., LL.D., Professor of Surgery, Medical College of Ohio and Dartmouth Medical College; Surgeon to the Cincinnati and Good Samaritan Hospitals. FREDERIC S. DENNIS, M. D., F. R. C. S., Professor of Clinical Surgery, Cornell University, New York City ; Attending Surgeon to the Bellevuc and St. Vincent Hospitals ; Consulting Surgeon to the Montefiore Home, New Yoi-k City. WILLIAM W. KEEN, M. D., LL.D., Professor of the Principles of Surgery and of Clinical Surgery, Jefferson Medical College, Philadelphia: Surgeon to the Jefferson Medical College Hospital; Consulting Surgeon to the Philadelphia Orthopedic Hospital and Infirmary for Nervous Diseases, to St. Agnes' Hospital, and to the Woman's Hospital; Membre correspondant etranger de la Societ^ de Chirurgie de Paris ;' Membre honoraire de la Societe Beige de Chirurgie. CHARLES B. NANCREDE, M. D., LL.D., Professor of Surgery and of Clinical Surgery, University of Michigan ; Surgeon to the University Hospital, Ann Arbor; Emeritus Professor of General and Orthopedic Surgery in the Philadelphia Polyclinic and School for Graduates in Medicine ; late Major and Chief Surgeon, U. S. V. ROSWELL PARK, M. D., Professor of Surgery, Medical Department of the University of Buffalo; Attending Sur- geon to the Buffalo General Hospital ; Consulting Surgeon to the Fitch Accident Hospital. LEWIS STEPHEN PILCHER, M. D., Surgeon to the Methodist Episcopal Hospital, New York City. NICHOLAS SENN, M. D., Ph.D., LL.D., Professor of Surgery, Rush Medical College, in affiliation with the Chicago University ; Professor of Surgery, Chicago Polyclinic ; Attending Surgeon to the Presbyterian Hospital ; Surgeon-in-Chief to St. Joseph's Hospital. FRANCIS J. SHEPHERD, M. D., C. M., Professor of Anatomy and Lecturer on Operative Surgery, McGill University; Senior Surgeon to the Montreal General Hospital. LEWIS A. STIMSON, B. A., M. D., Professor of Surgery in Cornell University ; Attending Surgeon to the New York and Hudson Street Hospitals ; Consulting Surgeon to Bellevue Hosjiital, New York City ; Cor- responding Member of the Societe de Chirurgie, Paris. J. COLLINS WARREN, M. D., LL.D., Professor of Surgery, Harvard University ; Surgeon to the Massachusetts General Hosi>ital. J. WILLIAM WHITE, M. D., Ph.D., Professor of Clinical Surgery, University of Pennsylvania; Surgeon to the University Hospital ; Consulting Surgeon to the Maternity and Samaritan Hospitals. PREFACE TO THE THIRD EDITION. Of the two former editions of the Ameriraii Text-book of Surgery there have been 'sold nearly 29,000 copies. This and its adoption as a text-book in over 100 medical colleges have been gratifying evidences of the approval of the profession and a stimulus to the authors to keep the work abreast of the times by another careful revision ; indeed, to all copies of the second edition printed during the last two years a chapter on the use of the Ront- gen rays and a number of illustrations were added without waiting for an entirely new edition. This chapter has now been brought up to date throuc^h the kindness of Dr. C. L. Leonard. In the present edition, among the new topics introduced are a full con- sideration of orrho- (serum-) therapy ; leucocytosis ; post-operative insanity ; the use of dry heat, at high temperatures ; Kronlein's method of locating the cerebral fissures ; Hoffa's and Lorenz's operations for contrenital disloca- tions of the hip; Allis's researches on dislocations of the hip-joint; lumbar puncture; the forcible reposition of the spine in Pott's disease; the treatment of exophthalmic goitre; the surgery of typhoid fever; gastrectomy and other operations on the .stomach; several new methods of operating upon the intestines; the use of Kelly's rectal specula; the surgery of the ureter; Schleich's infiltration-method and the use of eucaine for local anesthesia; Krause's method of skin-grafting; the newer methods of disinfecting the hands ; the use of gloves, etc. The sections on Appendicitis, on Fractures, and on Gynecological Opera- tions have been revised and enlarged, and many other changes and improve- ments have been introduced throughout the book. A considerable number of new illustrations, including a colored plate of several specimens of appendicitis (which we owe to the courtesy of Dr. Maurice H. Richardson, of Boston), have been added, and enhance the value of the work. Our thanks are due to our co-authors for their willing aid, to Prof. J. Chalmers DaCosta and Dr. Alfred C. Wood for much assistance in the revis- ion, and to Mr. W. B. Saunders, the Publisher, for valuable services ren- dered through his Editorial Department. The increasing specialization of the surgery of the eye and the ear, and the growth of the American Text-hook in size, have compelled the editors to omit these two chapters. This has been done with great reluctance, and in spite of the mo.st sincere appreciation of the admirable work of Drs. Burnett and Thomson. William W. Keen, \ J. William White.) PREFACE TO THE SECOND EDITION. The success of the American Text-Book of Surgery, as evinced by its extraordinary sale and its adoption as a text-book in over one hundred medical schools in this country, as well as by a large sale abroad, has been most grati- fvin]•) « 212 170 " 276 " 276 " 518 " 518 " 518 " 522 " 522 " 564 " 568 « 580 " 760 " 826 " 826 " 828 " 828 " 940 " 940 " 942 "1062 " 10()2 " 10(;4 " 1064 "1116 "1118 " 1 1 20 "1122 "1124 "1126 " 1 1 28 "1130 "1132 " 1176 "1178 "1180 " 1182 "1192 « 1194 AN AMERICAN TEXT-BOOK OF SURGERY. *BOOK I. GEJYERAL SURGERY. CHAPTER I. SUEGICAL BACTERIOLOGY. Bacteria or micro-organisms, or microbes, as they are variously called, belong to the lowest order of the vegetable kingdom, and are closely allied to the algae. They derive their name from j^axrijpiov, a rod, which some of them resemble in shape. The developed organism is, in form, a cell, consisting of a membrane enclosing a protoplasm. This protoplasm can be strongly stained by aniline dyes. The membrane, with difficulty separated from the contents, consists of a substance closely allied to cellulose. There is a gelatinous intercellular substance present in varying amounts and at times forming a distinct demonstrable capsule surrounding the microorgan- ism. During the process of division this holds the organisms together, and as they multiply may form the zooglea or glue-like mass in which they are sometimes grouped. Many bacterial growths are highly colored, being red, yellow, or blue ; according to some observers, the coloring-matter is in the protoplasm ; according to others, it lies in granules which have been exuded — both observations are true. Many bacilli and spirilla have the power of motion, which is attained either by means of flagella or by serpentine move- ments of the protoplasm. Micrococci and some bacilli, as the bacilli of tuberculosis and of anthrax, have no motility. The principal forms of bacteria are the micrococcus or globular form (xoxxoc, a berry), the bacillus or staff shape (bacillus, a little rod or staff), and spirillum or spiral shape. The micrococci, when developing rapidly, are seen often in the stage of division, and, being grouped in "pairs," are called diplococci. When arranged in rows or " chains " they are called streptococci (azpsTZTO^, a chain); when bunched together in "grape-like" masses they are called staphylococci {(rraifuhj, a bunch of grapes). Bacterial forms undergo no essential changes, although under differing conditions of soil, warmth, and moisture they may have an altered appearance. They multiply by fission, the 2 AN AMKRKAy TEXT- HOOK OF SURGERY. process bcitii; more rcutlily observed in the eoeei than in tht," ])aeilli. A number of the baeilli and a few spirilhi undergo germination, spore-formation taking phice within the eell before it is finally destroyed. There may be only one spore to oaeh cell, the spore thus formed ])ossessing an extremely dense enveloj)ing meml»rane, which protects it from external influences until it can find conditions favorable for future growth. The cell is usually distended either in the middle or at one end by the spore, and when the latter has reached its full developuient the cell-membrane undergoes a gelatinous softening, the cell breaks up. and the spore is free. When the spore begins to develop into a bacillus it loses its tough envelope, and is then nmch more readily destroyed. Bacteria are to be found everywhere, even occasionally in the interior of the healthy living tissues. They exist in the air, the soil, the water, in our clothing, on the* surface of our bodies, and on the mucous membrane of the intestinal and respiration tracts. They grow best in alkaline or neutral media. They multiply under favorable conditions with great rapidity : according to Cohn, a bacillus divides into two in the space of an hour, into four at the end of a second hour, and so on. In twenty-four hours the nuui])er of bacteria derived from a single bacillus will amount to sixteen and a half millions. It is chiefly in dead organic substances that they find a favorable soil, and it is through them that the process of decomposition is carried on. Those concerned in this process are called saprophytic or saprogenic. A certain number grow in the living body, causing by their presence morbid conditions, and are known as the pathogenic or disease-producing bacteria, among which those producing pus, the pyogenic bacteria, are of the greatest surgical importance. Pasteur divided bacteria into aerobic, or those which live best in the pres- ence of oxygen, and anaerobic, or those Avhich live without oxygen. The greater portion of the l)acteria are aerobic. Some are so sensitive that a slight diminution in the amount of oxygen is sufficient to prevent their development. These are called the oblijjate aerobic bacteria. Others, however, can grow well in media rich in oxygen, but are also able to grow where there is no oxy- gen. These are called the facultative aerobic bacteria. Most of the pathogenic bacteria belong to this variety, the oxygen of the body not being found in large quantities and being soon consumed by the micro-organisms in their growth. It is rare that we find a strictly anaerobic pathogenic form. An example of this variety is the bacillus of tetanus. The presence of sunlight is unfavorable to the growth of bacteria. The growth of the saprophytic, and particularly the anaerobic, bacteria upon albuminoid nuitter, whether animal or vegetable, causes the jirocess of decomposition, in the course of which the complex organic material is broken up and new chemical comjtounds are formed, some of whicii have been iso- lated and are called ptomaines {-ribna, a dead body). They are the animal bases derived from the direct action of the bacteria on albuminoid bodies, and have an excess of hydrogen and little or no oxygen in their make-up, and are, therefore, oxidizable. The sepsin of Bergmaiin and the cadaverin and putrescin of Brieger are examples of these chemical substances. The ptomaines are frequently very poisonous. Thus bacteria, harmless if intro- duced into the living animal, may by their growth in articles of food develop poisons which can cause the severest toxic symjjtoms (])tomaine- poisoning). The pathogenic bacteria, having gaineil entrance into an organism and multiplying there, cause disease in virtue of toxini< which they produce dur- ing their development. These toxins are set free or secreted by the bacteria, SURGICAL IIACTERIOLOGY. 3 and are analogous to the active principle of the venom of snakes and to the so-called extractives from our excreta. They apj)ear to be of an albuminoid nature and are more closely allied to the nueleo-albumins, though often ap- pearing to belong to the class of nucleins or proteids. From a physiological point of view, it is necessary to compare them with soluble ferments or enzymes, as they act by their power to split up or peptonize proteid bodies. If this action takes place locally, there is an inflammatory reaction devel- oped ; if the toxin becomes diffused through the body, constitutional svmp- toms apjiear. through the ferment-like action of the toxin upon the tissues of the boily and upon the thermic centers. In the most localized conditions, however, there is usually "septic absorption " enough to cause some general disturbance. It has been observed that while some animals are very susceptible to a given form of pathogenic bacteria, otliers are much less so. and still others are immune, and it has been found that immunity can be conferred upon sus- ceptible animals in various ways — by vaccines, by the injection of gradually increasing doses of the bacteria or their toxins, or by the blood-serum either of a naturally immune animal or of one that has been made immune. This immunity is probably due to cell activity in the organism. When the tissues are threatened by any pathogenic organisms and their toxins, new cells are called to the seat of the invasion by what is known as the chemotactic action of the bacteria. Some of the cells probably actually destroy the bacteria by a phagocytic action ; but by far the most important action of these cells is to furnish to the organism a material, the antitoxin, which is capable of neu- tralizing the toxin. In bacterial diseases these plasma, connective-tissue cells, and leucocytes by their action enable the organism to overcome the poisonous effect of the bacteria ; but in fatal cases the amount of toxin is sufficient to overcome the organism before these cells either make their appearance or develop in sufficient quantities to neutralize the toxins. For the consideration of Orrhotherapy (Serumtherapy) see page 81. The question of the direct transmission of microbic disease from parent to offspring is one not susceptible of easy demonstration. There are two routes through which hereditary disease may be communicated : through the placenta during intra-uterine life, or during the act of conception through the semen as a vehicle. Placental infection has been observed in small-pox, erysipelas, typhoid, and intermittent fever. Glanders has been transmitted in this wav from mare to foal, and the bacilli of anthrax, glanders, and malicr- nant oedema have been shown by experiment to pass through the placenta to the foetus. The tubercle bacillus has been found in the seminal fluid of consump- tives not suffering from tuberculosis of the genital organs: Tubercular lesions have been found in the human foetus at varying periods of intra-uterine life. There is therefore no doubt that this disease may be transmitted from parent to child : it is merely at the present time a question of the frequency and method of transmission of the disease (Baumgarten). It is also well known that syphilis may be acquired through both the semen (by impregnation) and the placenta, although the fact that no specific organism has as yet been discovered renders it impossible to furnish the bacteriological proofs. Most bacteria grow best at a temperature varying from 86° to 104° F. The saprophytic or putrefactive organisms prefer a temperature of about 75° F., or the ordinary house temperature. The pathogenic bacteria grow best at a temperature of from 95° to 104° F. Subjecting solutions containing bacteria to freezing temperatures does not generally kill the micro-organisms. They 4 AX A mi: RICA X TEXT-BOOK OF SURGERY. all lose the power of movement and reproduction at this temperature, but may preserve the power to resume their activity at a higher temperature. Cohn has reduced the tc-mperature of liquids containing bacteria as low as — 186° F. without destroying their vitality. Cold is therefore an agent which can- not be employed to destroy these organisms. Experiments show that organ- isms containing aporen^ like the bacilli of anthrax, are much more difficult to kill than the micrococci, which do not contain spores. If dry heat is used as a means of sterilization, it is necessary to expose the latter to a temperature of 212° F. for an hour and a half in order to destroy them. Bacilli containing spores, however, must be subjected to a temperature of 284° F. for three hours before they are rendered incapable of further growth. The dry heat, moreover, does not always penetrate easily to the centre of arti- cles subjected to this process, and most materials, and particularly instruments, are permanently injured by such high temperatures. The fact that boiling ivater will kill all kinds of organisms and spores in a few minutes suggested the application of hot steam for the purpose of disinfec- tion. Experiments showed that moist heat had in fact a much greater germicidal value than dry heat. In Koch's sterilizer all kinds of bacteria are destroyed in half an hour when subjected to a temperature of 212° F., even in those cases where the organisms were surrounded by voluminous dressings and materials of different kinds. Most of the ordinary pyogenic bacteria are micrococci, and therefore produce no spores. They are not tenacious of life, but are easily destroyed by heat. The bacilli of anthrax, malignant oedema, and tetanus, spore-bearing surgical bacteria, can practically be left out of consideration in the sterilization of surgical instruments. The following experiment shows how readily the ordinary surgical bacteria can be destroyed : Agar-agar tubes planted with a mixed growth of cocci were exposed to the action of steam in the Arnold sterilizer, and one tube was removed at the end of five minutes, a second tube at the end of ten minutes, and so on. A second series of tubes "was inoculated from the first tube removed, and all of them remained sterile. No further growth occurred in the original tubes, showing that the micrococci were destroyed by the action of the steam for the minimum length of time, five minutes (A. K. Stone), The Arnold sterilizer, which is cheap and convenient, and is in common use in America at present, furnishes a rapid and easy method of generating steam, by which surgical dressings and instruments may be sterilized. The best method, however, for the sterilization of instruments is to boil them for five minutes in water to which sodium bicarbonate, in the proportion of a teaspoonfnl to a quart, has been added. This prevents rusting by neutraliz- ing the carbonic acid in the water. The most powerful of bactericidal drugs is corrosive sublimate. A solution of 1 : 1,000,000 exercises a marked retarding influence upon the develop- ment of bacteria. A solution of 1 : 20,000 kills the spores of bacilli in ten minutes, and a solution of the strength of 1 : 1000, according to Koch, destroys the most powerful organism in a few minutes, without any previous preparation of the object to be disinfected. Aqueous solutions of carbolic acid, in the strength of 1 : 100, destroy in two minutes sporeless anthrax bacilli, and in the strength of 1 : 30 is sufficient for all ordinary surgical purposes, as it retards the development of the spores and kills the mature organisms. But solu- tions in oil have not the least influence upon the life of micro-organisms. Boric acid and salicylic acid have been regarded as useful antiseptic drugs, but their gennicidal power is now known to be almost nil. Iodoform is not a germicide, but markedly retards the growth of bacteria ; used as a powder, it SURGICAL BACTERIOLOGY. Plate I. m. 1. staphylococcus pyogenes aureus and albus : a, pus-cell with nuclei ; b, free nuclei. [Camera Lucida. Zeiss Apochromalic objective 2.0 mm. ocular 6.] WM 2. Streptococcus pyogenes in pus : a, pus-cell with nuclei ; b, free nuclei. [Same power as fig. 1.] SURGICAL BACTERIOLOGY. 5 has a tendency to stop serous oozhi>f, a condition favorable to bacterial growth. When moistened it liberates iodine, which has a certain antiseptic value. It does not procure asepsis of material, instruments, or wounds. The inicroseo/jicdl stiuh/ of bacteria has been greatly facilitated by the use of the Abbd condenser, which is placed Ijeneath the object-glass and throws a cone of ravs Avith a very broad base, thus giving powerful illumination of the section and making it possible to use higher powers wdiich would otherwise cut off the light. By this means the section is flooded with light and the structure of the tissues is made quite transparent. If now we use aniline dyes, which stain the micro-organisms, and wash the sections afterward in alcohol or acetic acid, the coloring matter will be in great part removed from the tissues, and the bacteria alone will retain the dye. In this way the bacteria are readily dis- tinguished from other objects, when examined Avith suitable lenses. For this purpose immersion lenses alone are reliable. Furthermore, contrast-stains can be often advantageously employed, by means of which the tissues are given a decidedly different though paler hue. Fragments of tissue which it is desired to examine for bacteria should be cut in pieces half an inch square and placed immediately in absolute alcohol. This should be changed once or twice, and in tAvo days the specimen is ready for cutting. The sections are placed for five to fifteen minutes in dilute solutions of fuchsin or gentian-violet. They are then decolorized in acidulated Avater, and afterAvard washed in water; after alcohol has been used to remove the water from the specimen it is mounted in Canada balsam. It is often necessary to examine the tirine or the sjnifa for tubercle bacilli, for the purposes of diagnosis. The urine, Avhich should be collected in con- siderable quantity, is alloAved to deposit a compact sediment. A small portion of this sediment is spread upon a thin cover-glass held by a pair of forceps. It is best to let this become nearly or completely dry, and then to pass the cover-glass three times gently through the flame of an alcohol lamp in order better to fix upon the glass the material it is proposed to examine. If the sediment is light, a second or even a third drop is added, and each time evaporated to dryness. The cover-glass is noAV placed in the following solution, (Ziehl), Avhich has been slightly warmed, for from five to ten minutes : ^ Fuchsin, 1 gram ; Carbolic acid solution (5 ^), 80 c.c. ; Alcohol (95 %), 20 c.c. It is then decolorized by placing it in a 5 per cent, solution of strong sul- phuric acid, Avhich removes the fuchsin from all but the bacilli. The length of time necessary for the bleaching process must be determined by experi- ment, and is hastened by transferring to 60 per cent, alcohol. The coA^er- glass is next Avashed thoroughly Avith distilled Avater, and is then placed in a strong Avatery solution of methyl-blue for about five minutes. The glass is finally washed in distilled Avater, dried thoroughly, and mounted in Canada balsam upon a glass slide. The bacilli appear under the micro- scope as minute red rods scattered about upon a blue background. The same 1 Koch-Ehrlich Stain for the Barjlltis of Tuberculosis.— 1. Sections or cover-glass preparations are left in aniline-water fuchsin (or gentian-violet) solution for twenty-four hours in the cold. 2. Transfer to a solution of nitric acid (1 part to 3 of water if sections, 1 part to 4 of water if cover-glasses) for two to three seconds (just long enough to pass them through). 3. Then transfer to 60 per cent, alcohol for a moment, to complete the decolorization. 4. Wash in water. 5. A contrast-stain may be made with a watery solution of methylene-blue (if fuchsin be the first stain) or vesuvin (if gentian-violet be first" used). 6. Wash thoroughlv in water, dry, and mount, if cover-glasses. Dehydrate, clear in oil of cedar, and mount, if sections. 6 AN AMA'BICAX TEXT-JiOOK OF SUltGERY. method of staininj^ is applicable to the detection of tlie tu])ercle bacillus in the sputa of jihtiiisical jiaticnts. A drop of the sputum is selected from one of the tough yello^v clumj)s Hoatiiig in the sputum and placed upon the cover-glass; a second cover-glass is then placed on top of it, and the sputum is pressed out into a thin layer. The glasses are then separated and dried, and furnish two specimens for the coloring process. Bacteria are not usuaUy found in the healthy tissues of the body, although occasionally they may be concealed in certain structures "which show no symp- toms of disease, and first make themselves manifest after the infliction of an injury or during the course of some intlamnuitory process. Cocci and spores may remain latent in cicatrices for a considerable length of time, awaiting a suitable opportunity for development. It is not uncommon to discover the presence of tubercle bacilli in individuals apjiarently healthy. An injury or a slight bruise under such circumstances "would offer an opportunity for their development either as a local or a general tul)erculosis. Micrococci are often found tem- porarily in the blood of individuals "whose vital powers are enfeebled. They may disappear quite rapidly — even in a tew hours — without having given rise to any Avell-defined pathological process. Bacteria are found in all kinds of true inflammations. The term '' sim- ple inflammation" is intended to designate that variety in which no micro- organisms are found. This form of inflammation is a more limited one than was formerly supposed, and is confined chiefly to those jjrocesses "which follow injury and are concerned in repair if bacteria are excluded (Senn). The forms of bacteria most frequently met "with in surgical diseases are those "which produce suppuration. These organisms are known as the pus microbes or pyogenic cocci. The Pus microbes consist of several varieties, but the most common form is the staphylococcus pyogenes aureus (PI. I, Fig. 1), so called from the grouping of the cocci in clusters. Its shape is globular, and it meas- ures from 0.7 to 0.87 micromillimeters in diameter. It multiplies by division, but the line of fission is difficult to see. It is a very resistant organism, and requires several minutes' boiling or steaming to destroy its power of gro"wth. It is readily stained by all the coloring agents. It grows well at the ordinary house temperature, but is more active "when growing at a temperature nearer that of the body. It does not need a large amount of oxygen for its growth. When cultivated in the test-tube upon beef gelatin it forms at first a yellowish-white layer, which later changes to an orange color ; hence the last part of its name — aureus. If thrust deeply into the gelatin, the upper surface softens as the growth forms, and becomes liquefied in virtue of peptonizing action exerted by the organism. It has a peculiar odor of sour paste. The aureus is found abun- dantly outside of the human body. It can be obtained from dirty dish-water, the soil, or the air, particularly in foul hospital wards, but its most conmion seat is the superficial layers of the skin, particularly of the axill» and other moist parts, and also under the ends of the finger-nails. It is also found in the mucus of the pharynx and digestive tract. Other forms of the'])yogenic cocci, but less frequently seen than the aureus, are the staphylococcus pyogenes albus and the staphylococcus pyo- genes citreus. These may occur alone or be combined with the aureus. The Streptococcus pyogenes (PI. I, Fig. 2), is an important variety of the pus cocci. The arrangement of the organism is in chains or rows, six to ten being usually attached together. These cocci measure about one micro- millimeter in diameter. On culture-media the growth reaches its development in four or five days, and has at first a transparent whitish look, but later a SURGICAL BACTERIOLOGY. Plate II. 1. Bacilli of tuberculosis in sputum. [Camera Lucida. Zeiss apochrornatie objective 2.0 mm. ocular 6.] T ; / 2. Gonococcus from gonorrheal pus. 3. Bacillus tetani. Cover-glass preparation [Sawie power as fig. 1.] from culture by Kitasato. [Same power as fig. 1.] SURGICAL BACTERIOLOGY. 7 brownish color. Tlie streptococci are found under normal conditions in the saliva, socrctions dt" the nostrils, vaj^ina, and urethra. The Bacillus pyocyaneus is an organism wiiieh is found in green or blue pus. It is a small, thin rod with distinctly rounded ends. It has no spores, has a flagellum at one end, and is actively motile. The pigment is deposited from the bacilli when in contact with oxygen, and is then seen principally on the exposed edges of dressings. The substance thus found is termed injocyanine. The pyogenic cocci are found in all acute abscesses. I'he staphylococci are found in circumscribed abscesses, as boils, carbuncles, suppurating glands, em- pveraa, osteomyelitis, etc. The streptococci are more frequently seen in the spreading inflammations, as phlegmonous cellulitis, erysipelas, ulcerative endo- carditis, and metastatic abscesses such as are seen in pyemia. In order that suppuration should take place it is not simply necessary that the pyogenic cocci sliould be introduced into the living tissues. It is found that other conditions are of ecjual imj)ortance. Cheyne has shown by experi- ment that the number of bacteria injected is an important factor. The dose must be sufficiently large. It is owing, probably, to this fact that many cases of imperfect asepsis in surgical operations often heal well. Doses of less than 18,000,000 of the Proteus vulgaris when injected into the muscular tissue of a rabbit seldom cause any result, and it rec^uires so large a number as 250,000,000 to produce a circumscribed abscess. But the Htate of tKe tissues in Avhich the organisms are arrested is also a matter of great importance. Tissues which have been damaged by injury or inflammation are not so resistant to tlie action of bacteria as Avhen in a state of health. A healthy peritoneum may receive and absorb a large number of bacteria, but if damaged during a laparotomy, so that a considerable portion of its secreting surface has been destroyed and at the same time considerable oozing of blood and serum has taken place from the injured surfaces, a soil favorable for the growth of the organisms is provided and a septic peritonitis may result. Tense sutures are more likely to be followed by " stitch abscesses " than where the sutured margins of the wound come easily together. The question has arisen. Can sujJjniration take place without the presence of bacteria ? Steinhaus has shown that calomel, and also nitrate of silver, when injected into the tissues can produce pus in certain animals. Even the chemical substances formed by the pyogenic cocci, when separated from them and injected, can produce non-bacterial pus. But, as Senn remarks, the matter remains practically where it was before, as clinically we do not meet Avith examples of acute" suppuration without the introduction of the pyogenic cocci into the system. Foreign bodies or mechanical irritation cannot produce pus without the aid of bacteria. The pus-producing power of the cocci lies in their ability to liquefy the fibrinous exudation of inflammation. The pyogenic cocci are not usually found in cold abscesses. It was sup- posed that this form of abscess was produced by the tubercle bacillus only, but Ernst and others have found the aureus and albus in several cases of psoas abscess. It is possible that the failure to obtain cultures from this kind of pus is due to the dying out of the organism owing to the age of the abscess. The Streptococcus erysipelatis resembles closely in all respects the streptococcus pyogenes, and the weight of evidence is at present strongly in favor of their identity. In all cases it is the cause of the disease, and direct proof has been given of its power by inoculation of open wounds in the human subj ect. The Gonococcus (PI. II, Fig. 2) is the specific organism which pro- duces gonorrhea. It measures 1.25 micromillimeters in diameter, and is 8 AN AMERICAN TEXT- HOOK OF SURGERY. usually arran^iod as a dijilococcus. One of the most striking peculiarities ■which distinguishes it from nearly all other forms of micrococci is its ability to penetrate cells and multiply rajiidly within them. In this way it may he read- ily recognized under tiie microscope. It is difficult to cultivate, as it will oidy grow on blood-serum ami when isolated from other cocci. The gonococci are stained well with methyl-blue, and may be prepared for examination by the cover-glass method mentioned previously. The organisms grow more readily on those mucous membranes which possess a cylinder epithelium or one closely allied to it, as the membranes of the male and female urethra, the uterus, and the conjunctiva. It does not penetrate below the epithelial layer, the more deep-seated suppuration, such as bubo, being due to the presence of the pyo- genic cocci. The Tetanus bacillus (I'l. II, Fig. 3) is a large, slender rod with somewhat rounded ends. Spore-formation takes place at the end of the bacillus, and, as it enlarges the cell considerably, gives it the so-called drumstick shape. It is mov- able, belongs to the strictly anaerobic organisms, and rapidly dies when exposed to the air. It is readily colored by methyl-blue and fuchsin. It can be culti- vated in cultures of gelatin mixed with grape-sugar, and grows well at the bottom of the inoculation puncture, whence it sends out innumerable little pro- longations, giving the growth the appearance of the fir tree. It is difficult to separate from other organisms, but improved laboratory techniijue has made it comparatively easy to obtain pure cultures. The spores are found in garden soil, in masonry, in decomposing liquids, and in manure. Hence the frequency of the disease in those employed about stables. It is quite frequently met with in the dust of the streets, but owing to its anaerobic nature is not easily inoculated into the living tissues. Brieger has obtained from cultures a number of toxines, to one of which he has given the name tetanin, and inasmuch as the same group of symptoms are obtained experimentally by the toxines as by the bacilli, and as the latter are hard to find in the blood and internal organs in individuals who have died of tetanus, it has been thought probable that the symptoms of the disease are produced, in a great measure, by this substance. The Tubercle Bacillus (PI. II, Fig. 1). — This organism was first seen under the microscope by Bauingarten, but Koch cultivated and fully identified the organism with the disease in 1882. The bacilli are small, thin rods, two to four micromillimeters in length — that is, about one-half the diameter of a red blood-corpuscle. The rod is slightly bent in the middle and its ends some- what rounded. The longest rods are usually seen in phthisical sputa. They are usually single, occasionally being found in pairs or arranged in the form of the letter V. They do not possess the power of motion. The bacillus possesses great powers of resistance to destructive agencies, the organisms in tuberculous sputa being destroyed only after twenty minutes' boiling. The expectoration can be kept for months and even years in a dried state without destruction of the bacilli. They are stained by the ordinary aniline dyes with far greater dif- ficulty than any other bacteria, and, in common with the bacilli of leprosy, which they closely resemble, do not yield to bleaching fluids like all other bacteria. The bacilli are found between the leucocytes in the tubercles, in the epithelioid cells, and also in sm:dl numbers in the giant cell, being generally seen at its periphery. The organism is very difficult to cultivate, and grows well only on a hardened blood-serum or a combination of the ordinary nutrient media with glycerin, for which latter agent it appears to have a special predilection. When cultivated on agar the first signs of the growth appear at the end of fourteen days, and one to two weeks more pass before full development has taken place. It appears then as thick scales of a dull grayish-white color, which are very dry SURGICAL BACTERIOLOGY. Plate 111. \ \ / \ / 1. Bacillus of malignant oedema. Cover-glass preparation from spleen of white mouse. [ Camera -Lucida. Zeiss apochrmnatic objective i.O mm. ociilar h.] / x' \ 2. Bacillus anthracis. (/'over-glass preparation from spleen of white mouse. [iSame p(/wer as Jig J.J SURGICAL llM'TFJUOUKiY. 9 and brittle. The material lor culture is usually obtained by inoculatin0, and has been called the keystone to the arch of bacteriolofry. It is very large, being 1.5 micromilli- meters in thickness and 3 to G micromillimeters in length. The spores when forming are seen as bright, glistening bodies in the centre of the rods. The bacilli are comj)aratively delicate, but the spores belong to the most durable of bacterial organisms, and are therefore generally used as a standard test of the values of disinfectants. In animals, chieHy cattle, they produce the disease known as anthra.x or splenic fever, and are found in immense numbers in the caj)illaries of the internal organs. Pasteur succeeded in weakening the strength of these bacilli by cultivating them at high temperatures or for a long time, and thus produced an attenuated virus by means of which he was able to protect animals from the disease by "vaccination." The immunity, however, is not permanent, and does not protect against infection through the intestinal canal. CHAPTER II. INFLAMMATION. Inflammation is a disturbance of the mechanism of nutrition, and affects the structures concerned in this function. It is "the response of living tissue to injury." It was formerly supposed to be an increased nutrition of the palt, but the more modern view, as expressed by Sanderson, is that the condition is the result of damage which, if not severe enough to cause death of the part, will be followed by a series of characteristic changes in the blood-vessels and the surrounding connective tissue. As the result of this disturbance, however, we have conditions favorable for the process of repair or for the neutralization or removal of the primary microbic cause. These changes give rise to tlie Jive cardinal HjimptoniH of inflammation — pain, heat, redness, swelling, and Impaired function (dolor, calor, rubor, tumor, functio l;csa). In an acute inflammation of the connective tissue (cellulitis) we find the part greatly swollen and sensitive. The tissues also become much firmer than they were before. The skin is not only redder than natural, but is much warmer to the touch. The patient complains of a thro]tl)ing pain in the part, and if an incision is made through the skin the flow of blood is unusually I'apid and copious. The function of the limb affected for the time being is impaired, and the muscles in the immediate neighborhood become more or less rigid. As the disease progresses all these symptoms are intensified, and finally at the point of severest pain the part becomes softer, an examination shows that fluid is collecting beneath the skin, and we recognize that suppuration has taken SURGilCAL liACTElllOLOCJY. Plate IV. Isjc^^* «™. .-^^^ ^SSS!^J^ e B o m o^»' I hi i' i'-o i-^-k / 1. Section of human tonarue showing priant-cells of tuberculosis, aurronnded with inflammatory tissue [submiliary tubercle]: a, muscular liber [^Vamera Lucida. Zeiss ohjeclive Ul) ocular U] "^ V 2. Giant-cell of tuberculosis of human tongue before stage of cheesy degenerations showing bacilli. [Camera Lucida. Zeiss apochromatic objective 2.0 mm. octUar 6'.] INFLAMMA TION. 11 place. The symptoms may, however, hegin to abate before this stage is reached, and the part may gradually return to its normal condition. The intianimation is then said to have terminated by resolution. In order to understand the meaning of these symptoms a study of the patliology of inflammation is necessary. The changes seen in the blood-vessels claim our first attention. The experiments of Cohnheim in 18G7 greatly increased our knowledge of this part of the process. Previous to that time the great number of cells found in an inflamed part were supposed to be due to the proliferation of the cells of the connective tissue, but Recklinghausen showed that many of the connective-tissue cells possessed the power of motion and wandered into the inflamed tissues. They are called amoeboid cells from their resemblance to the amoeba. Following this discovery came that of Cohnheim, who identified the cells in the inflamed tissue with the white corpuscles of the blood or the leucocytes. If Ave paralyze a frog with curare, and draw a loop of his intestine through an incision made on one side of the abdomen, we obtain in the exposed mesen- FlG. 1. Fig. 2. Normal Vessels and Blood-Stream (original). Dilatation of the Vessels in Inflammation (original). tery a thin, transparent membrane, in which the circulation can be studied with ease under the microscope. It may also be readily observed in the web of a frog's foot or in the frog's tongue. The exposure of the mesentery is sufficient in itself to produce an inflammation, but an application of a caustic will be necessary, in the case of the web or the tongue, to bring about the same result. If we examine such an area under the microscope, we can gen- erally see an arteriole with its rapid pulsating current of blood, and near by a small vein in Avhich the blood flows with a more steady movement. The red blood-corpuscles occupy the axis of the blood-vessel, and the few white corpuscles which are seen float i« the more sluggish stream of plasma which occupies the borders of the lumen and appears as a transparent layer (Fig. 1). The capillaries are not readily seen, but careful observation 12 AN AMERICAN TEXT-BOOK OF SURGERY will detect the elianiiels through wliieh, occasionally, a few hlood-corpnscles pass. At the beginning of" the inHaniniatory process the rajiidilif of the fliiiv of blood is iireatli/ iiicrcascd and a greater amount of blood is observed in the part. Tlie Imiuni of the artcn/ is yreater than before, and the column of red corpuscles is much broader and fills a comparatively greater portion of the lumen of the vessel. The capillaries are now quite distinctly seen, and nre crowded with blood-corpuscles. They appear to be considerably larger than they were before. The tlow of blood is also more rapid in the veins, and it is of a brighter and more arterial color. This condition of the circulation is known as Jiypi'vemia (Fig. 2), and is presently succeeded by a slowing of the current, which soon becomes much more ^"^•- '^ sluggish than in the normal state. This is first noticed in the capilla- ries, and soon after in the veins. The })ulsation, however, continues in the arteries. As a result of this diminution of speed the column of blood-corpuscles becomes broader, and almost completely fills the in- terior of the vessels. In the veins a great aceuriiulation of tvhite cor- puscles takes place on the interior of the walls. Being of a lower specific gravity than the red cor- puscles, the leucocytes are not forced onward with the same mo- mentum, and are drop])ed, as it were, here and there on the vessel- wall. Finally they are so greatly increased in numbers that the entire Avail of the vessel appears to be lined Avith leucocytes. The Avhite corpuscles also accunmlate in the capillaries, but not to the same extent. In the arterioles these corpuscles cling more readily to the Avail during the diastole, but they are soon swept aAvay again into the blood- current. Another step in the process, beginning concurrently Avith the sloAving of the blood-stream, is the emigration of the leucocijtes from the interior of the veins (diapedesis) (Figs. 3 and 4). Many leucocytes, b}' a change of shape, send out little prolongations of protoplasm into the substance of the Avail, and slight protuberances are soon seen projecting from its outer surface. These enlarge, and Ave noAv see the corpuscles presenting an hour-glass appearance. The por- tions Avithin the vessel soon folloAv those Avithout, and the leucocytes escape from all contact Avith the vessel. Many corpuscles appear to folloAv one another through the same point in the wall. AVhether there are actual holes (stomata) between the endothelial cells of the vessel through Avhich the leucocytes escape or not is still a disputed question. The amoeboid movements of the leuco- cytes are effected by a poAver of those cells to change their shape. Processes (pseudopodia) are throAvn out from the protoplasm of the cell, Avhich noA\' becomes elongated or fiask-shaped. As the ])rotoplasmic mass resumes its more or less globular form, the main portion folloAvs the protruded mass, and stasis of Blood and Diapedesis of White Corpuscles in Inflammation (original). INFLAMMA TION. 13 a change iu the position of the cell results. The white corpuscle is a minute mass of granular, or, according to some authors, reticulated, protoplasm, con- FiG. 4. 10.30 P.M. 10.40. 11. 11.15. 11.40. 12.20. Stages of the Migration of a Single White Blood-corpuscle, through the Wall of a Vein in One Hour and Fifty Minutes (mesentery of the frog ; Caton). taining one or more nuclei, and without any limiting membrane. The cells which accumulate in large numbers outside the walls of the blood-vessels in Fig. 5. Changes seen in the Leucocyte of a Frog during Ten Minutes (original). inflammation have the same appearance. Migration takes place to a limited extent also from the capillary vessels, but no such process is observed in the walls of the arteries. Leucocytosis. — In most local inflammatory processes, as well as in most acute infectious diseases and in many toxemic conditions, the number of polynuclear leucocytes in the circulating blood is greatly increased. This is usually considered to be due to what is known as chemotaxis, by which is to be understood an attraction exerted by the products of bacterial activitv 14 ^iV^ AMERICAN TEXT-BOOK OF SURGERY. upon the leucocytes in tlie blood-iuiikinf]; organs, which arc probably stimu- lated to an increased rate of production. The number of leucocytes jier c.cm. of blood is thus increased from HUGO ± (the normal number) up to 20,000-40,000 or even 100,000, according to the severity of the infection and the resisting power '"'^*- ^- ^"■' '^- of the organism. Viru- lent infections well re- sisted cause the greatest leucocytosis. Where the infection is very mild, or where it is so overwhelmingly violent that the resistance of the system is easily overpowered, the leuco- , T., , rrv. 1,1 , 1 . ■ cyte count may be nor- Normal Blood. The Blood in Leucocvtosis. "^ , , -^ , mal or subnormal. Any suppurative process, such as appendicitis, felon, osteomyelitis, ischio- rectal abscess, perinephric abscess, etc., usually gives rise to leucocytosis. In a general way, the course of the leucocytosis follows that of the tem- perature ; but the leucocytes may increase while the temperature falls, and in some cases {e. ^., in appendicitis) the increasing leucocytosis may be evidence of* a spreading peritonitis which temperature and other signs would not indicate. In the diagnosis of deep-seated suppurative processes, septicemia, and pyemia the leucocyte count is not infre(|uently of value. After free drainage of an abscess cavity has been established by incision or otherwise, the leucocyte count falls rapidly to normal and remains so, despite a free purulent discharge. If, however, the proper drainage is in any Avay interfered with, the leucocyte count again rises. "Nervousness" never increases the leucocyte count. The examinations should always be made directly before a meal, since a slight increase (up to 15,000 or 17.000) may be caused by the influence of proteid digestion. The blood-plaques probably comprise several different elements, into the nature of Avhich it is not profitable here to enter. They are colorless, irregularly oval or grape-like masses, from 1.5 to 3.5 fx in diameter, and usually cling together in masses. No nucleus can be made out. In various inflammatory conditions they may be increased in number. Normally, they are about 200,000 per c.mm. The changes seen in the circulation account for two of the cardinal symp- toms — viz. heat and redness. The rapid return of color seen after pressing the finger on an inflamed surface indicates the increased amount of blood. The copious bleeding from incisions in an inflamed tissue shows the increased detei'mination of blood to the part and the distention of even the smallest capillaries. The bright scarlet redness is also an indication of the active hyperemia Avhich exists in acute inflammation. In the more chronic forms, or in those in which the congestion is very intense and the flow of blood is consequently not so rapid, there is a bluish tinge to the reddened surface. If the color cannot be entirely pressed away Avith the finger, this is due either to decomposition of the coloring matter of the blood, which leaves a yellowish tinge behind, or, if a reddish tint remains, it is caused by the presence of red blood-corpuscles which have been forced out of the vessels by the inten- sity of the pressure. This "hemorrhagic" form of inflammation has often INFLA MM A TION. \ 5 a much deeper and more irregular coloring than is usually seen in acute inflammation. Redness is entirely absent in bloodless parts, as in the cor- nea, but in this case we find a hyperemia of the vessels of the conjunctiva, and later an actual development of vascular loops in the direction of the inflamed spot. It was at one time su])posed that the increased warmth of the part was due to a local production of heat. It is now known that the local rise of temperature is due to the greater amount of blood which flows throu'^h the vessels. One of the most constant symptoms of inflammation is the swelling. This is rarely absent, and is seen even in non-vascular parts. The increase\ i.raiuilaii' ia'ocess new vessels begin to form in loops which develop from the pre-exist- ing vessels. On the surface of a capillary loop a mass of granular protoplasm is seen, which gradually increases in size and grows to an elongated mass of solid nucleated protoplasm which projects toward the edge of the wound. These prolongations either become attached to the wall of another vessel, or unite with similar outgrowths from other vessels or with the cells of the sur- rounding tissue. Later, the central portion of these newly-formed structures melts away, and they become hollow and establish a communication with the vessels from which they spring. The wall of the new vessel is at first homo- geneous, but later becomes nucleated and lined with endothelium. In this w^ay a mass of capillary loops form on either side of the wound, eventually becoming united and forming an exceedingly rich capillary network in the new tissue. As cicatrization completes itself many of the spindle cells and round cells dis- appear. Some undergo granular degeneration and are absorbed ; others wander into the adjacent lymph-spaces, and are taken up again into the circulation; many, after reaching a certain stage of development, are destroyed by the more active cells in the reparative process. As the cells vanish new fibers make their appearance, and the wound becomes thus firmly united. In the mean time, on the surface a clot or crust of broken-down blood-corpuscles, epithelial scales, and exudation-material has formed, underneath w^hich new epithelium develops from the deeper layers of the rete mucosum which covers in the sur- face of the wound. When from loss of tissue or other cause it has not been possible to close a wound, and the lips are separated widely from one another, union can only take place by the process of healing by granulation, or second intention (Fig. 9). If we watch such a wound with the naked eye we shall observe, in the course of an hour, that a film has formed upon the surface ; the wound has become glazed by the deposition of a thin layer of coagulated fibrin. This layer, at first trans- parent, soon becomes stained with masses of coagulated blood and fragments of 28 AN AMERICAN TEXT-BOOK OE SURGERY. fibers torn from their surroun(lin<^s and lyin^ upon tlie surface. This hiyer is also soon occupied by numbers of emigrated leucocytes. In this way the wound is covered over so that the structures beneath can no longer be recognized. The discharge which flows from the wound is at first of a reddisli liue, and consists chiefly of bloody serum in which are floating fragments of broken-down tissue. This gradually changes to a grayish color, and is found to contain more white corpuscles and fewer red corpuscles as time goes on. In a few days the dirty layer covering the surface of the wound is washed away by the discharge, which has now assumed the yellowish-white or creamy color of pus, and the wound is said, in surgical parlance, to clean off". As the d6bris is swept away we find underneath a surface of bright and irregular-shaped nodules wliich are called granulations. The time which granulations take to form may vary from two or three days to a week, according to the health of the individual or the nature of the tissue involved. Microscopically, tbe tissue consists chiefly of small round cells mingled with epithelioid or larger cells, such as are seen in the so-called granulation-tissue, the origin of which has already been described. The velvety appearance of a granulating surface is due to the little elevations on the surface produced partly by growth of colls near the blood-vessels and partly by the oedema of certain portions of the tissue. The cavity of the wound is gradually obliterated, partly by the growth of the granulations and partly by cicatricial contraction by wdiich the edges of the wound are approximated. In the mean time the epidermic cells by prolifera- tion begin to cover in the margins of the open surfiice of the wound, and a thin bluish-white border indicates the presence of a fresh epithelial cell-growth. New formation of epithelial cells cannot occur in the center of the wound unless some fragment of epithelial structure, such as a portion of a papilla, sweat-ducts, or hair-follicles, may have remained, from which such an outgrowth could take place; hence cicatrization always progresses from the circumference toward the centre. Occasionally the growth of granulations is so exuberant that they project above the surface of the skin, and the epithelium may then be unable to cover in all the surface. This "proud flesh," as it is popularly called, must be removed with the knife or caustic before the healing process can be completed. Healing may take place by direct union of granulating surfaces, or healing- by third intention. It readily occurs in wounds ren- dered aseptic and kept so by the use of iodoform or sterilized gauze. The gauze being removed on the second or third day, the surfaces from which little or no secretion exudes are brought in apposition and unite. After the cicatrix has freely developed, it consists of fibers interwoven in various directions possessing great contractile powers, which cause many of the delicate vessels to disappear and the red scar to grow pale. In extensive scars this contraction gives rise to groat deformities, particularly Avhen the wound is situated in regions where two adjacent portions of the body may be thus bound together by a dense scar. Examples of tliis may be seen after burns on the neck or at the flexures of the joints (see Burns). Granulations are not always firm and red: occasionally they are pale and flabby, which appearance is due to an unusually oedcmatous condition. These are often seen in tubercular processes. Erothistic granulations bleed easily and are excessively painful. They appear to be caused by some mechanical disturbance of the wound. The surface of the wound will sometimes be found covered with a membrane which has a diphtheritic appearance, and is caused by imperfect development of the capillary vessels or is due to their obstruction by inflammation. A coagulation-necrosis of the upper layers of the granulation is thus produced. THE PROCESS OF REPAIR. 29 The healing of subcutaneous wounds does not differ essentially from the j)rocess already described. Kejjair, however, usually takes place without suppuration. In this case we find the seat of the wound occupied by a blood- clot, sometimes of considerable size. As repair progresses the extravasated blood is gradually absorbed, and granulations j)usli out from the surrounding connective tissue and ramify in the clot, which furnishes a favorable culture soil for the new cell-growth. The amount of inflammation which will accom- pany this process depends upon the degree of injury or upon bacterial infec- tion. In the case of infection by sloughing of the integuments or of intra- vascular infection, suppuration will take place and an abscess will form. The same mode of healing under a blood-clot occurs when an open sterile wound has been filled with an ase})tic blood-clot which is allowed to remain. The layer of clot which covers the surface becomes hard and dry, and gradually loses its dark color. As the clot shrinks the epithelial margins follow close upon its edges, while the connective tissue-growth beneath has been substituting itself for the fibrin and blood-corpuscles which are gradually absorbed. When the wound has healed the remains of the surface clot break up and come away with the dressings, and a firm cicatrix is disclosed. If infection of the wound has taken place, the clot will break down and be swept Fig. 10. 6- Process of Repair of a Wound : a, cells forming connective-tissue ; 6, leucocytes ; c, newly-formed blood- vessels (original). away with pus which forms, and the wound Avill then heal by granulation. This method of healing by organization of the blood-clot, as it has been called, is the one which usually occurs in ruptures of the internal organs, such as the liver or the kidneys. The formation of fibrillar connective tissue is accomplished by the prolifera- tion of the fixed cells of the connective tissue. Cell-division takes place either directly or indirectly. Direct cell-division (Fig. 10), which is simply a segmen- tation of the nucleus followed by a division of the whole cell, was thought to be the ordinary mode of cell-growth, but the indirect method is the one which usually occurs. This latter is known as karyokinesis (Fig. 11). When such 30 AN AMi:i!I('AX Ti:XT-lU)OK OF SLRUKllY a mode of cell-division is iil)oiit tf) take ])lacc, the delicate reticulum of fiber of which the nucleus is composed when in the (juiescent state — an ^. ,^ ^ Temperature Chart of a case of Aseptic Fever (original). torn necessarily associated with infection of the wound, but after the anti- septic treatment of wounds was perfected it was discovered that many wounds thus treated were accompanied by a considerable rise of temperature, par- 1 See pp. 60 and 63. THE TRAUMATIC FEVERS. 35 ticularly those in whicli a large amount of blood-clot existed between the lips of the wound, or in large wounds where, necessarily, more or less bruising of the tissues has occurred (Fig. 16). It has been shown by experiment that a large number of chemical sub- stances when introduced into the circulation will produce a rise of tempera- ture. Among them is the fluid obtained from defibrinated blood, which contains a substance known as fibrin-ferment. When injected into animals this ferment produces extensive coagulation of blood in the vessels and death. Other substances, as pepsin, and even water, when injected will produce febrile disturbance. During the healing of a large wound there is necessarily a breaking down of minute portions of tissue and blood-clot, which, Avith eifused serum, are absorbed in greater or lesser quantity. These chemical substances are but slightly altered from their normal condition, but when absorbed appear to have what is known as a pyrogenous or fever-producing action. The normal temperature of the body is 98.4° F., or 37° C. During this form of constitutional disturbance the temperature may rise to 102° F., and not return to normal for several days. Beyond the pyrexia there are but few symptoms in aseptic fever. The patients thus affected do not suffer from malaise or delirium, and are rarely conscious of feeling ill. They may be able to sit up in bed or to move about the room. This form of fever is seen during the healing of simple fractures and of wounds in which no drainage has been employed, or in very large wounds which are healing by first intention. Traumatic, Septic, or Surgical Fever. — Before the introduction of the antiseptic method of treatment all wounds healed with more or less inflam- mation, even when suppuration did not occur, and this Avas supposed to be a part of the process of repair. The amount of constitutional disturbance was considerable, and was called surgical or traumatic fever. Examples of this type are seen to-day in Avounds that have not been treated antiseptically, partic- ularly those Avhich are d\ie to injuries and have been exposed to septic infection. The presence of bacteria of various kinds in the secretions of such wounds gives rise to a fermentative process during Avhich ptomaines are developed and are absorbed, producing fever. Very fcAv bacteria are found in the blood during this type of fever, and if present they are rapidly eliminated. There is no progressive development of bacteria in the system, as in septicemia. Surgical fever is not to be confounded with suppurative fever, for, although suppuration may occur in inflammations Avhich produce the former, the tem- perature falls when suppuration takes place, and the decomposing fragments of tissue, together with the ptomaines they produce, are Avashed aAvay. Sur- gical fever is produced by the products of decomposition rather than by those of suppuration. The constitutional symptoms correspond pretty accurately with the con- dition of the wound and the amount of inflammation. There is a sharp rise of temperature a day or tAvo after the operation or injury ; the skin is hot and dry, the pulse rapid, and the tongue coated. The subjective symptoms are also more marked; the patient suffers greatly from heat, thirst, and rest- lessness, and there may be delirium. The urine is scanty and highly colored. On the evening of the second day the thermometer indicates a temperature of 102° or more in the axilla. The folloA\dng morning the temperature drops a degree, to rise higher than before in the evening. On the third or fourth day, when suppuration is established, the wound cleans off, granula- tions spring up, the chemical substances which have caused the pyrexia are 36 AN AMERICAN TEXT-BOOK OF SURGERY. no longer absorbed, and the temperature falls. Surgical fever does not last over a week, by the end of uhich time the symptoms of fever liave entirely disappeared. ihe constitutional disturbance in this form of fever usually corresponds pretty accurately with the local condition of the wound. Wlien, therefore, all symi)toms are well marked, infection of the Avound siiould be suspected and the dressing should be removed for a thorough examination. The lips of the wound are usually found red, swollen, and tender, and on pressure decom- posed blood-clot, and perhaps pus, may ooze at one or two points from between the lips of the wound. The stitches should be removed, the wound opened and disinfected, and a moist dressing in the form of antiseptic fomentations should be applied. In slight disturbances such a dressing may suffice to carry off all decom- posing secretions without removing the stitches, and the wound may heal after all by first intention. Experience only will enable the surgeon to decide whether to interfere or to leave the wound undisturbed. Suppurative fever, or, as it is sometimes called, secondary fever, is a term employed to denote that febrile condition which prevails after sup- puration has been established. It occurs only in those cases in which pus is retained, so that some of its constituents are absorbed. If at the usual period of defervescence of surgical fever we find the tem- perature remains high, or there is a rise after the usual fall, it is highly probable that an accumulation of pus has taken place between the lips of the wound and is unable to escape. The pyrexia is probably produced by the absorption of a chemical substance which has been formed by the pyogenic organisms. The micrococci are not found to any extent in the blood or tissues, and the fever curve drops as soon as the pus is evacuated. It is evident, therefore, that there is no progressive infection of the system by virus already absorbed, as in pj^emia. When pus is confined in a wound the constitutional disturbance is usually well marked. There is a sharp rise of temperature, accompanied perhaps by a chill. If the pus is evacuated promptly, the suppurative process may be arrested, but occasionally the surrounding tissues become affected and the pus burrows in various directions. The fever corresponds pretty accurately Avith the degree of local inflam- mation. During the acute stage the fever remains high with slight diurnal variations ; later, when a state of chronic suppuration has been established and pus is to be found accumulating at the bottom of numerous sinuses, the fever curve assumes a remittent type, falling in the morning to the normal point, to rise again several degrees in the evening. This is the type of the so-called hectic fever (Ixr^zor, a habit), accompanying the chronic suppura- tions Avhich are so marked a complication of the tubercular process. ^^ ith the continuance of the fever there are marked emaciation and prostration. The pulse becomes weak and rapid. Diarrliea and night-sweats are often prominent symptoms, and unless the sup])uration is checked the patient may succumb to septic poisoning or to exhaustion. In the more chronic form the emaciation is gradual. Enlargements of the lymphatic glands and amyloid degeneration of the internal organs are often found. The treatment of acute suppuration consists in the establishment of thorough drainage with disinfection of the entire suppurating surface. For this purpose free incisions should be made in order to lay open the pus-cavity and render its walls accessible to the curette. After all the infected material that can be removed is scraped away, the remaining surfaces should be THE TRAUMATIC FEVERS. 37 thonnighlv cleansed with peroxide of ljydro«ren or sulphurous acid (1 : 30) and disinfected with solutions of carbolic acid, corrosive sublimate, or zinc chloride. When joints are involved the question of resection must be considered. The presence of an amyloid degeneration of the kidneys, as revealed by an examination of the urine, is a contraindication to resection, and in these cases amputation may offer a better chance of saving life. Free stimulation and a nutritious diet are indispensable. In many cases placing the patient in the open air for several hours daily may bring about a decided improvement, even in serious cases. When, however, those pro- cesses are associated with tuberculosis the prognosis is most unfavorable. Surgical Scarlet Fever. — A scarlet rash may occur after surgical opera- tions, and the eru))tion may bo followed by desquamation. In many of these cases there has been an infection of the system through the wound^ with the virus of scarlet fever. Such infections are more likely to occur if the wound involves a mucous membrane, as in cases of lithotomy. The appearance of the symptoms of surgical scarlet fever are, according to Paget, quite "disorderly," the period of incubation, for instance, being much shorter than usual. Scarlet rashes may occur also as the result of vaso-motor disturbances, or from the absorption of a chemical poison from the wound, or from bacterial invasion, as in pyemia and septicemia. Urethral fever is a term given to the chill and pyrexia which often folloAv the introduction of a catheter or sound into the bladder. It has been cited as an example of the purely nervous origin of fever. Many of these cases are probably due to the infection of a wound of the mucous membrane caused by the instrument, but some cases are not to be accounted for in this way, but are to be explained only by reflex nervous action. Traumatic Delirium. This term is used to denote those forms of delirium which occur as the result of injury, and are not due to alcoholism. The anatomical seat of delirium is in the cortical gray matter of the brain. The delirium is due either to functional disturbance or anemia of that region or to inflammations of the cortex and meninges — more particularly of the middle and posterior lobes (Hunt). The causes of delirium are as numerous almost as the injuries which give rise to constitutional disturbance, but there are certain lesions which seem more prone to this form of functional disturbance than others. In some cases of shock there is considerable mental exaltation and excitement which are quite characteristic, the condition being known as "pros- tration with excitement." There is usually no marked delirium, but at times a temporary mental aberration of a well-defined character. It may precede and accompany cerebral lesions, such as hemorrhage from trauma, or throm- bosis and embolism. Delirium is often noticed in children and the aged after capital operations, after operations for cataract, and also in many forms of chronic inflamma- tion in aged, anemic, and feeble patients. Among other surgical lesions, severe burns and scalds and facial erysipelas may be mentioned as par- ticularly liable to be accompanied by delirium. In some individuals pain alone is often sufficient to produce a temporary mental aberration, which dis- appears immediately upon the subsidence of the pain. This form of delirium is allied to the so-called delirium nervosum of the German writers — a condition of nervous disturbance which comes on after injuries in hysterical subjects. It may occur in the stage of convalescence following erysipelas and other inflam- 38 AN AMERICA y TEXT-BOOK OF SURGERY. matory diseases in nervous patients. It is characterizetl by considerable mental depression. Transitory psychical disturbances may also follow sur<^ical opera- tions, and there may be developed at times not only melancholia, but a suicidal mania. A nervous delirium without fever is occasionally noticed after opera,- tions upon portions of the body supplied with unusually sensitive nerves. The operation for phimosis, with an unusual am(»unt of irritation of the ;^lans penis, is an example. Severe nervous disturbance and delirium following operations or injuries, without a corresponding amount of inflammation or fever, should cause the surgeon to inquire as to the possibility of poisoning by iodoform or carbolic acid — conditions readily shown by an examination of the urine. The treatment of this form of delirium consists in the removal of all local sources of irritation, in the application of ice to the head in some ca,ses, and in the use of the bromides and hyj)notics. If due to cerebral anemia from loss of blood, suitable stimulation is indicated. Opium is usually not well borne, and should be reserved for those violent cases which cannot be controlled in any other way. Post-operative Insaxity. Occasionally after an operation or an accident, even when the head was not the part involved, a condition of genuine insanity develops. This condition is afebrile, occurs in those who are weak and exhausted, is especially common in persons who possess a hereditary tendency toward the development of psychoses, and is similar to and identical with post- febrile insanity. The most common form encountered is characterized by great mental confusion (confusional insanity of Wood), but either mania, melancholia, or delusional insanity may arise. The prognosis, as a rule, is favorable if sys- tematized delusions are not present. The treatment consists in the adminis- tration of large amounts of nourishment, the use of tonics, and proper men- tal exercise. Most of these cases should be treated in a hosj)ital for the insane. Delirium Tremens. This disease is a form of mental disturbance characterized by delirium, and accompanied by a peculiar tremor of the muscles, occurring in individuals habitually intemperate in the use of alcoholic stimulants. It follows either a debauch or some injury which suddenly confines such a patient to bed; hence its consideration here. It is said to be much less common in countries where wine and beer are the national beverages than in those in which spiritu- ous liquor is consumed. The habitual use of various drugs is said to produce it, as opium, tobacco, and cannabis indica, and even tea and coffee. The term mania-a-potu is used to denote an acute type of delirium following a debauch, in which the patient may become maniacal. Delirium tremens was formerly supposed to be due to an inflammation of the brain. Usually, however, the post-mortem appearances indicate no sign ef active inflammation beyond some thickening of the meninges. According to Hunt, there is a condition so characteristic that it has been called "wet brain," consisting of a passive congestion with serous exudation in and under the pia mater, filling the ventricles and following the convolutions. Chronic gastric catarrh is also found to exist, and atheromatous degeneration of the arteries, fotty liver, and Bright's disease. The symptoms of delirium set in gradually. The patient, removed from his ordinary surroundings, complains of feeling uncomfortable ; he is THE TRAUMATIV FEVERS. ;i9 restless and tremulous; there is inueli depression of spirits, and his sleeji is disturbed with nightmares ; he talks in his sleep, and may wander about during the night, but the next morning asserts that he has slept well. When it fol- lows an injury, the onset of the disease is usually sudden. With the full develoj>nient of the disease there is complete insomnia, with a muttering delir- ium fre((uently broken by loud cries, and a peculiar tremor of all the mus- cles. The patient is constantly employed pulling the bed-clothes about, tear- ing off dressings and splints, and endeavoring to get out of bed. He appears to be more or less insensible to pain, and may walk upon a broken leg Avithout showing any signs of suffering. He is the victim of all manner of delusions, usually of a horrible nature. The hallucinations take the form of hideous animals and insects ; occasionally they are obscene in cliaracter. The patient may be momentarily recalled to himself sufficiently to give an intelligent answer, but relapses immediately into his previous condition. There is little fever, although occasionally there may be a marked rise of temperature. The pulse is weak and quick, and there is rapid loss of strength, due to the small amount of nourishment taken during the debauch and the later inability to retain food. In favorable cases, after two or three days of insomnia sleep comes sud- denly, and on awakening the delirium is found to have disappeared. In severe or fatal forms the prosti^tion increases rapidly and is a marked feature, the pulse foiling greatly in strength. The patient may die suddenly from heart failure. Pneumonia, a complication unusually frequent in alcoholic subjects, may supervene, and bring about a fatal issue. The prognosis of the disease is, however, usually favorable. Among the most reliable symptoms which give a clue to the patient's condition are the pulse and temperature. The weak and rapid pulse is a measure of the prostration, and the rise of temperature is a warning of complications such as pneumonia or septic infection of the wound. The prophylactic treatment consists in the employment of alcoholic stim- ulants in moderate quantities, of capsicum and digitalis, and of nourishing food. The last is only secondary in importance to sleep. By these means the nervous system is steadied and the strength of the patient maintained. Any indica- tion of nervousness or insomnia should be met Avith a free use of the bromides. An attack may in this way be warded oif. During the attack mild stimulation with liquor or beer is usually advisable, although the use of stimulants must be determined by the circumstances of each case. The drugs which are most frequently used at the present time are chloral hydrate and the bromides. It is probable that sulphonal in sufficient doses to cause sleep has rather too depress- ing an influence upon the heart's action. The question of the use of opium in this disease has been much discussed. In mild cases it is not necessary, but it may be of much value in quieting restlessness when it is of great importance that splints or dressings should not be disturbed, or when the delirium is of so acute a type that all other remedies fail to control the patient. 40 AN AMERICAN TEXT-HOOK OF SIJROEHY. CHAPTER V. SUPPURATION AND ABSCESS. SECTION I— SUPPURATION. Suppuration is due to the action of the pyogenic cocci upon the tissues, •ind is the usual termination of infective infianiniation. It is the process by means of which the exudate and the tissues involved become liquefied and con- verted into pus. The organisms most frequently found in pus are the staphylo- coccus pyogenes aureus and albus. They have a tendency to accumulate in clusters, and when growing in the tissues produce circumscribed forms of sup];uration. The streptococcus, which is sometiuies present, on the other hand, shows less tendency to cause local suppuration, but spreads rapidly through the tissues by the lymphatics, and eventually gives rise to a diffused form of suppuration. When grown on beef gelatin the staphylococcus causes a liquefaction of the culture medium in virtue of its peptonizing action, which is due to the presence of a soluble peptonizing ferment, and it is in consequence of this action that the fibrinous exudate and the inflamed tissues become converted into pus. That the pyogenic cocci are the cause of suppuration has been abundantly shown by microscopical investigation and experiment. They are found in the pus of all acute abscesses, and sometimes in cold abscesses. The failure to find them in the latter class of abscess has been explained in various ways. By some these abscesses are supposed to be caused by the bacillus of tuberculosis alone, but the most probable explanation is the dying out of the organisms and the deposition of their remains as a sediment. Experiments on animals show that these organisms when injected in sufficient quantity under the skin will produce suppuration. When absorption takes place rapidly, however, a larger (juantity can be injected without producing suppuration. In man inoculation through abrasions or Avounds, and even through the uninjured skin, will cause suppu- ration. Garre produced furuncles of the forearm by rubbing in a culture of the aureus. The question of suppuration without the agency of bacteria has been carefully studied recently. Ex})criments on animals with the injection of calomel, mercury, turpentine, and croton oil show that certain drugs can produce in certain animals pus, or, as it would be better called, " puruloid material," containing no bacteria. Non-bacterial pus can also be produced by introducing cultures of cocci which have been sterilized by heat. In this case the organ- isms have been removed, but their chemical products still remain, and are undoubtedly important factors in the production of inflammation and suppu- ration. Practically, however, the surgeon never has to deal with non-bacterial suppuration. Among the predisposing causes of suppuration may be mentioned diminished vitality of the tissues. The healthy body is intolerant of bacteria, and will resist the invasion of a mass of organisms which an inflamed or diseased part may be unable to withstand. The milder types of inflammation seem partic- ularly well adapted to encourage bacterial growth. Some of the severest types of suppuration, such as acute osteo-myelitis, follow often slight blows or inju- ries. The delicate reticulum of blood-vessels found in the medullary cavities of bones furnishes a convenient lodging-place for swarms of bacteria, owing to the slowness of the blood-current and tlie tortuous course of the blood-channels. When the circulation has been impaired or arrested by an extravasation of blood or a congestion of the part, the conditions are favorable for an intravas- SUPPURATION AND ABSCESS. 41 cular infection if organisms happen to be circulating in the l^lood at the time. As we have seen, micro-organisms may from time to time be found in the cir- culating blood, particularly in individuals of feeble constitutions. The ana- tomical nature of the part will therefore fjivor suppuration in certain localities. A most familiar example is the lymphatic gland tissue. There the organisms which have invaded the tissues through a wound, and have found their way into the lympliatic vessels, are arrested, and a glandular abscess results. The condition of tlie blood is also a predisposing cause, as tlie tendency to carbun- cular inlianniKition in dia])etes shows. The material which forms as the result of suppurative inflammation is pus. Pus is a yellowish-white fluid of the consistency of milk or cream, of an alkaline reaction, and commonly nearly odorless. It has a specific gravity of about 1030, and when allowed to stand it separates into a clear fluid known as pus serum, and a sediment which averages from 10 per cent, to 20 per cent, of the whole amount. The liquor puris, or pus serum, is a pale greenish-yellow fluid which does not coagulate spontaneously, and contains an albuminous substance known as peptone. The salts which it contains are present in about the same proportion as in the blood. The sediment consists of pus-corpuscles, the pyogenic cocci and the other forms of micro-organisms that may be present, and fragments of broken-down tissue. Most of the pus-corpuscles are the altered leucocytes which have escaped from the blood-vessels with the exudation; others are derived from the prolif- erated fixed connective-tissue cells. When first taken from a fresh abscess many of them are found to possess amoeboid movements. They are a little larger than the white blood-corpuscles. Their protoplasm is somewhat gran- ular, and when acetic acid is added to them they are found to contain several nuclei. This polynuclear condition was supposed to be evidence of an ability of the pus-corpuscles to proliferate, but it is now recognized as a sign of degen- eration. They also occasionally contain drops of fat ; others are full of large granules, which, Avhen they break up, liberate a granular detritus Avhich may be seen suspended in the fluid. The color of pus is occasionally blue. This is due to the presence of the bacillus pyocyaneus, ordinarily considered a harmless organism, but the presence of which indicates slowness of repair. Orange-colored pus is caused by the presence of hematoidin crystals, and is found in some forms of inflammation. It is probably due to the fact that many red corpuscles in the exudation have been broken up by the septic process, The peculiar foul odor of pus which comes from the neighborhood of the vagina or rectum is due to the presence of the bacillus pyogenes foetidus. The thick creamy, odorless pus which flows from an acute abscess was formerly known as healthy or laudable pus. It contains comparatively few bacteria. Pus may occasionally undergo decomposition ; in this case the micro-organisms of putrefaction also are found in it, and the pus-corpuscles are broken down and much diminished in number. This is known as ichorous pus, and Avhen mixed with blood which is seen flowing from a rapidly-spreading abscess is called sanious pus. These unhealthy forms of pus are very acrid and give an acid reaction. A microscopical examination of the connective tissue in suppurative inflam- mation shows that in the early stages of the process the stellate cells of the tissue lose their prolongations, become rounded, and undergo karyokinesis, and 42 .l.V AMElilL'Ay TEXT-BOOK . 1 BSCKSS. 43 tion. In this ease the whole part is apt to become gangrenous. Free incisions are foHowod by the escape of a sero-punileiit iliiid. There is profound constitu- tional disturbance with perhaps acute septicemia. Probaldy in these cases there is a mixed infection, and bacilli of putrefaction are mingled with the micrococci. When infection of a wound takes place the slight swelling which ordi- narily accompanies the healing process is much increased at some portion of the wound, and is accompanied by reddening and induration. This will usually occur around one of the stitches which has been the source of infection, or pus may collect in some part of the wound Avhere the surfaces were not accurately brought in apposition and where the Avound fluids have accumulated from imperfect drainage. The rise of temperature will give speedy warning of the approach of suppuration in such cases. The general plan of treatment to be adopted in cases of spreading suppuration is the emploA'ment of free incisions which expose the extreme limits of the suppurating area. This operation should be accompanied by a thorough curetting of the surface of the pus-cavity to remove the bacteria from the surrounding tissues and by thorough disinfection with appropriate antiseptic drugs. In the case of an extremity this can best be accomplished by immersion of the limb in an antiseptic bath. The agent used should be largely diluted (sublimate 1 to 10,000, or carbolic acid 1 to 500) to prevent poisoning by the drug. Following the bath antiseptic fomentations may be applied. For this purpose some of the milder drugs containing carbolic acid, as sulpho- naphthol, may be used. When other methods fail, irrigation is often successful. Sterilized water may be used for this purpose or. extremely Aveak solutions of disinfectants. If a dry dressing is preferred, iodoform or aristol or boric acid may be dusted freely upon the part, and the Avound may then be packed with an antiseptic gauze. The use of stimulants and careful feeding should be the chief feature of the general treatment of the case. SECTION II.— ABSCESS. An abscess is a circumscribed collection of pus, and is caused usually by the presence of the staphylococci in the tissues. When these organisms invade a part, Ave find even at the end of tAventy-four hours an enormous number of leucocytes in the exudation which takes place. The connective-tissue fibers are SAA^ollen and the lymph-spaces are distended and filled with cells. As we have already seen, the fixed cells of the tissue undergo changes of an active nature, and form nucleated cells Avhich cannot be distinguished from the leucocvtes : they are, however, usually much less numerous than the latter. The small vessels are dilated and distended with blood, and in many cases with leucocytes. The cocci in the mean time inci^ease in number and tend to group in masses. As they exert a peptonizing action upon the intercellular substance and the fibrin of the exudation, liquefaction takes place in the center of the inflamed tissue, and an abscess is formed. The walls of the pus-cavity are formed by a zone of granulation-tissue, the cells and intercellular substance of which have not been broken down by the action of the bacteria, and remain to form a protecting layer betAveen the infected area and the surrounding healthy tissues. This is the mode of development of an abscess in some of the looser tissues like connective tissue. In the denser structures and in the internal organs when a plug of microccocci becomes arrested at some point in the circu- laton, as, for instance, in a glomerulus of the kidney or in a lymphatic gland or in the cutis vera, Ave find that the tissue immediately surrounding it undergoes a chemical change due to the action of the ptomaines upon its cells, the 44 AX AMKRICAX TKXT-li( )<)k' OF SURGERY. result of which is that coaofulation-nccrosis of the tissue takes plaee. This ring of dead tissue is readily seen in sections taken for microscopic })ur- poses, as the necrosed area does not take any of the staininjr fluids ■\\hicii act upon the surrounding tissues. Outside of this area a ring of granulation- tissue forms. Eventually the necrosed area is invaded both by the bacteria and the leucocytes, and becomes liquefied by the action of the cocci. An abscess of this type, when examined microscopically, will show a mass or plug of bacteria in the center, around which is a layer of pus and shreds of tissue enclosed in a zone of granulation-tissue, the miscalled pyogenic membrane of the older ])athologists, who thouglit that the wall of an abscess was a sort of secreting surface from which pus was formed. The symptoms of an acute abscess are usually well marked. The large amount of local swelling, Avith a varying amount of pain according to the density of the tissues which lie between the cavity of the abscess and the surface, is accompanied frequently by a chill or a gradual rise of temperature as pus begins to form. As the abscess forms a progressive softening of the integuments takes place until the pus reaches the surface. Considerable resist- ance will be offered by certain tissues, as fascia, a joint capsule, or bone, and the pus may take a devious path before the abscess begins to point. Fluctua- tion will now be distinctly felt, and redness witli oedema of the skin and subcu- taneous tissue will indicate the near approach of pus. The skin becomes stretched and thin and its vessels compressed, and over a certain area the blood Avill not circulate ; death of this area occurs, and the abscess then easily breaks through it. It is not usually difficult to diagnosticate the presence of an acute abscess. Acute forms of inflammation may occur, however, in which the sensation of fluctuation is apparently well marked when an incision fails to reveal the pres- ence of pus. No harm is done, the inflammation may be relieved by such an operation, and the impending abscess prevented. Deeply seated abscesses under a dense fascia, as in the neck, may be over- looked, as no fluctuation can be felt. The local oedema and brawny feel, with other signs of suppuration, are always a sufficient warrant for a deep but care- ful exploratory incision at an early date to prevent wide and dangerous burrow- ing of the pus under the fascia. An aneurysm may, however, be mistaken for abscess, particularly when its presence is obscured by the symptoms of inflam- mation, and the use of the knife in such a case Avould be a grave error. An aneurysm will declare itself by its less acute history, by the thrill, bruit, and expansile pulsation, and can exist only in connection Avith a large vessel. Some forms of rapidly-growing malignant tumors may also simulate suppura- tive processes. In all such cases the use of the aspirator or of the hypoder- matic needle is of great value. The heat of the part, the sense of fluctuation, the local oedema, and the rise of temperature, as shown by the thermometer, are all important diagnostic symptoms, and will usually be sufficient to estab- lish the presence of an abscess. When an acute abscess breaks the pus which is discharged is of a thick cream-like consistency, and is frequently mingled with soft sloughs of con- nective tissue or fascire, or fragments of lymphatic glands Avhich have under- gone a necrosis due either to the great tension of the part or to the formation of destructive chemical substances by the pyogenic cocci. The treatment of acute abscess consists in incision as soon as it can be definitely ascertained that pus has formed, and sometimes even earlier. Nothing is to be gained by delay, and extensive injury may be inflicted upon the surrounding tissues if the abscess is not opened early. In some regions SUPPURATION AXI> ABSCESS. 45 the (lan^'crs of delay are very great. An abscess in tlie neighborhood of the appendix verniifonnis may produce a fatal peritonitis if allowed to remain unopened. ])eep-seated abscesses of the neck may burrow widely, and mav seriously interfere with res])iration by pressure upon the trachea. An abscess near the rectum should be opened as soon as induration is discovered, in order to prevent a fistula. If no pus has formed the incision may prevent it. The incision, as a rule, should be a free one, and so made as to favor drainage and to leave the least conspicuous scar. The finger should then be introduced to determine the size and situation of the various pockets. In case of abscesses near large vessels or other important structures Hilton's method may be used to advantage. This consists in making an incision through the skin and deep fascia by the knife. The seat of the pus can be ascertained by pushing in a pair of closed hemostatic forceps or blunt scissors or a sinus dilator, and the opening so made can be easily enlarged by drawing them out open. If neces- sary, to facilitate the escape of the pus by gravity, a counter-opening can often be made by pushing the hemostatic forceps entirely through the tissues to the opposite skin, and cutting between its partly opened blades. The cavity of the abscess should be thoroughly emptied, curetted, and syringed out with anti- septic solutions. These may consist of corrosive sublimate 1 : 5000 or carbolic acid 1 : 100, or if a milder antiseptic fluid is needed phenyl (sulpho-naphthol) 1 : 250. When the pus. and sloughs have been thoroughly removed in this way, a drainage-tube of a sufficient size should be inserted, and retained either by a safety pin inserted through its extremity or by stitching it to the skin to avoid its falling out of the abscess, or, still worse, of being lost in its cavity. An antiseptic poultice (made of aseptic cotton and cheese-cloth and wrung out of a weak antiseptic solution) may be applied, or a dry absorbent dressing may be used. In freely-discharging abscesses the dressing should be changed at the end of twelve hours or less, and the cavitv Avashed out again. The fountain syringe fitted with a tube ending in a conical glass point is well adapted for this purpose. It gives a continuous stream, and causes but little pain to the patient in its application. In a few days the inner surface of the abscess-wall "cleans off" and healthy granulations make their appearance. The tube can be shortened daily as the cavity shrinks, but the time of its removal will depend entirely upon the length and ramifications of the cavity. Cold abscess is caused in the great majority of cases by tubercular infection, although occasionally it may be of syphilitic origin. In the ordinary tubercular cold abscess we find a peculiar membranous wall formerly called the "pyogenic membrane" (the " pyophylactic membrane" of Park), which is readily scraped off and is infiltrated Avith tubercles. In the syphilitic abscess no such condition exists. This membrane, as also the pus of cold abscess, is more fully described in the chapter on Tuberculosis. The organisms found in the contents of the abscesses before they are opened are the bacilli of tuberculosis. Sometimes before, and always after they have opened spontaneously or have been opened without due antiseptic precautions, there is added the infection with pyogenic cocci, or the bacteria of putrefaction. This is an example of what is called mixed infection. Clinically, we find few of the symptoms of acute abscess. There is in most cases no redness of the part until the abscess is about to break. Pain and heat are usually wanting. The swelling is frequently quite large and fluctua- tion is distinct. Such abscesses may exist for months before they burst. Dur- ing their formation the constitutional disturbance is usually slight. There may be, however, considerable emaciation due to the progress of the tuberculosis. The temperature is usually slightly raised, and in cases of doubtful diagnosis 46 A\ AMi:i:icAX 'nixr-nooK of surgery. the tlieruiometer ■will give valuable inroriuation. (.)iie of the most coniiuon seats of cold abscess is the vicinity of the spinal colunin, and such abscesses are due to tubercular disease of the vertebra} (Pott's disease). The \)\\^ bur- rowino; along the psoas muscle (])soas abscess) points above or below J*(»uj»art's lig;»ment or on the thiixh external to the vessels, or it may ))oint in the lumbar region near the margin of the (juadratus lumborum muscle (lumltar abscess). Treatment. — These abscesses should be opened with every antiseptic precaution, otherwise true suppuration with hectic fever will follow from the mixed infection which inevitably occurs. They must lie tlioioughly scraped out and the wound stuff'ecl with iodoform gauze. Such treatment is best adapted to those abscesses which have few ramifications, and the walls of which are evervAvhere accessible to the curette. Treves treats psoas abscess by an opening in the loin which passes external to the latissimus dorsi and erector spinas muscles and through the quadratus lumborum and psoas muscles. The diseased vertebra is first explored, and fragments of bone are removed, and the abscess-wall is repeatedly scraped and wijied out, and also washed out with a douche of corrosive sublimate, 1 : 5000, at 100° F. The wound is then closed and dressed with an iodoform dressing retained by a bandage. The patient should be kept at rest in the recumbent position for many months. If the abscess-cavity refills, the operation should be repeated. In many cases of cold abscess it is well to evacuate the contents with the aspirator and to inject some preparation of iodoform. A large canula is sometimes necessary, owing to the thick plugs of cheesy matter which obstruct the flow of pus. The cavity is now washed out with a 3 per cent, solution of boric acid. Among the preparations of iodoform recommended is a 5 per cent, ethereal solution, but not more than three ounces should be injected for fear of iodoform-poisoning. It causes considerable pain. A 10 per cent, emulsion of iodoform in olive oil can be introduced safely. The fol- lowing emulsion is also sometimes used, and is considered safe so far as poi- soning is concerned : Iodoform 10 parts ; glycerin 20 ; mucilag. gum. Acac. 5 ; carbolic acid 1 ; and Avater 100 parts. From one to three ounces should be injected, and the abscess-cavity should be carefully manipulated so as to intro- duce the drug into all the pouches. Tavo or three such injections are made at intervals of three or four weeks. A cure may not be obtained for several months. Equal parts of iodoform and olive oil may be injected freely into tubercular sinuses which have resulted from the burstinff of such abscesses. If this treatment fails, recourse may be had to incision, as above described. The general treatment consists of good food, cod-liver oil and other tonics, and a careful selection of climate. Mechanical contrivances may be needed for the support of joints or bones. Abscesses of different regions of the body ])ossess characteristic peculiarities. The most common form of abscess in the integuments is the furuncle or boil. This is caused by a growth of the cocci from the deeper layers of the epidermis doAvnward along the sheaths of the hair-follicles, and a final accumulation near the root of a hair. If the cocci are arrested in their groAvth at the mouth of the follicle, a pustule is formed, but in many cases the development contiimes doAvnAvard and a true furuncle is developed. The boil in its early stages appears as a pustule. The amount of coagulation-necrosis is considerable, and the result is a '"core" Avhich is discharged Avhen the abscess breaks. A crucial incision Avill promptly arrest the groAvth of a boil in its early stages, or an application of the liquefied crystals of carbolic acid may be used if it is desired to avoid a scar. A carbuncle is a suppuration and necrosis of the subcutaneous tissue, and is situated most frequently under the thick srrrrRATioN and abscess. 47 skin of the back of the neck. Like tlie ])oil, it is at first superficial, ])ut rapidly spreads to the deeper parts. It has erroneously been called a collec- tion of boils, owing to the fact that numerous points of })us a]»))ear on the surface, and when opened it ])resents a honevcond)ed appearance. This peculiarity of the carbuncle is due to the anatomical structure of the skin and subcutaneous tissues of this part of the body. The pus forms in the dense fibrous reticulum -which underlies the thick cutis, and makes its Avay to the surfiice through the columniie adipostc, in which the fine lanugo hairs are situated, causing disintegration of the parts and sloughing of the tissues and the formation of a central crater (Warren). ^Phe carbuncle should be freely incised and all the sloughs removed by the sharp spoon or scissors, and the part disinfected as thoroughly as possible. Complete excision of the car- buncle with thorough disinfection of the parts will often lead to an arrest of the process and a speedy convalescence. Abscess of the lymjjhatic glands may form in the groins, as the result of suppuration complicating venereal disease; in the neck, following inflammation of an adjacent mucous membrane; in the axilla, as the result of suppuration in the fingers or hand ; or in the saphenous glands, from suppuration in the toes or foot. A deep abscess of the neck should be opened by Hilton's method. A retropharyngeal ab- scess should be opened through the neck, the incision being made at the anterior or posterior edge of the sterno-cleido-mastoid muscle. Felons and palmar abscesses are often supposed to be caused by direct local trauma, but are more frequently due to indirect infection by pyogenic cocci which probably follows an injury of some kind. The precise seat of the suppura- tion will vary according to the situation of the infection. Nowhere is an early incision of more importance, as the usefulness of the finger or hand is at stake. When abscesses form in and around the internal organs they are usually designated by special names derived from the parts with which they are asso- ciated, as perinephric, psoas, or subdiaphragmatic abscesses. Sub- phrenic abscess, as the latter is sometimes called, is usually due to a circum- scribed peritonitis caused by a perforating ulcer of the stomach, duodenum, or appendix, and more rarely of some other portion of the intestinal tract or to inflammation of the liver, spleen, or kidney. The abscess sometimes contains air and may resemble pyopneumothorax. It may be treated by an intercostal or an abdominal incision (Mason). Abscesses of the liver are occasionally observed in America. They are caused by inflammations in the intestinal tract and contain a brown grumous material, in which is found the amoeba coli {vide infra). Abscess is found in bones near the epiphyseal line (" Brodie's abscess ") in acute inflammation (osteomyelitis), and tuberculous abscesses are often seen near the ends of long bones in connection with joint-disease {vide infra). Abscesses in the brain are occasionally observed as metastatic abscess or in connection with middle-ear suppurations or after injuries. Pus in the thorax is most frequently found in the pleural cavity, consti- tuting empyema. An empyema can rarely be cured by aspiration, but should be promptly opened and drained. A cure may be retarded by the mechanical difficulty of bringing the abscess walls together, owing to the contraction of the lung and the rigidity of the chest Avail. In these cases resection of several ribs is necessary to allow the thoracic wall to come in contact with the lung (Estlander's or Schede's operation). Tuberculosis is often a complication of this variety of suppuration. Abscesses occur also, but much more rarely, in the lung itself. These can be opened and drained 48 AN AMERICAN TEXT- BOOK OF SURGERY. by ail incision bet^vceii tlio ribs or by resection of one or more ril)s. The operation is much simplified if adhesion of the lung to the thoracic wall has already taken place. Details regarding abscesses of special regions will be found in their appropriate places. CHAPTER VI. ULCERATION AND FISTULA. SECTION I. ULCERATION. An ulcer is a loss of substance due to inflammation of a superficial structure. There is also a tendency to necrosis or death of the granulations which are formed by the tissues in an effort at repair. If the retrograde changes equal the reparative, the ulcer will remain stationary ; but if the for- mer exceed the latter, the ulcer will constantly increase in size. The causes of ulceration are of widely different origin. Some develop during the course of certain infectious diseases, particularly those of a chronic type, as syphilis, tuberculosis, leprosy, and glanders. Another kind of ulcer depends upon widespread disturbances in nutrition. These are known as dyscrasic or constitutional ulcers. To this class belong the scorbutic ulcers, which appear to form as a result of disease of the blood-vessels brought about by the absence of a sufficient variety of nutriment ; also the cachectic ulcers, due to exhaustion of the system from starvation, exposure, or disease. Ulceration may also be ftivored by certain local conditions. A passive hyperemia due to retardation in the venous circulation may be the cause of the varicose ulcer. Decubitus, or bed-sore, is due to a feeble circulation, which is easily arrested by continuous pressure from lying in bed, causing death of the part. Neuro-paralytic ulcers are caused by diminished innervation. The so-called trophic disturbance belongs in this class. A striking example of this variety is the ''mal perforant," or perforatm;/ ulcer of the foot, for which the nerves of the leg have been stretched with success. We may also have ulceration as the result of the breaking down of maJif/uaut (/rowt/is, as sarcoma and carcinoma, particularly in the epithelial forms of the disease. Finally, ulcerations occur which are the result of certain mechanical dif- ficulties obstructing the healing process. Extensive loss of substance, burns of the skin, or avulsion of the scalp may result in the existence of a permanent granulating surface constantly contracting or enlarging, but never fully healing. Sloughing of the flaps of an amputation-stump may be followed by an adhe- sion of the integuments to the ends of the bones, which protrude slightly and are covered with granulations. Wounds may be prevented from healing by mechanical irritation, such as chafing or rubbing or the application of irritating ointments or acids. A section taken from an ulcer and examined microscopically shows generally a thickening of the tissues around the ulcer due to a hypertrophy of the papilli^J and an accumulation of the epidermic cells, which sometimes form an overhanging mass, giving the appearance of " callous edges. In the deep layers of the rete mucosum and in the papillary layer of the true skin deposits of blood pigment are often seen. The surface of the ulcer is covered with a layer of granulation-tissue. This tissue may resemble the type seen in ULCERATION AND FISTULA. 49 healthy granuhitions, being composed of roiuul cells closely packed together and supplied with a rich capillary network of blood-vessels, or we may find a condition of coagulation-necrosis due to breaking down of portions of the granulations. In old ulcers the cell-growth is much less abundant, and a gelat- inous intercellular substance is seen in which clusters of cells are scattered here and there. The granulation layer is quite superficial, and beneath it we see either the nearly normal tissue or a mass of fibrous cicatricial tissue. Ulcers are either acute or chronic. An acute ulcer is a spreading ulcer, in and about which acute destructive inflammation exists. Such an ulcer is of irregular outline, its floor is sloughy, its discharge is purulent, and the parts about are inflamed. In such a case the ulcer is rendered aseptic and the parts about it are treated as is any case of acute inflammation. A chronic ulcer is an ulcer which does not tend to heal or which heals very slowly. In treating a chronic ulcer it is necessary to discover the cause which prevents healing and remove it. Such ulcers occasionally develop epithelioma at their margins, but this is very rare. In such cases they should be freely excised at an early date, together with any enlarged glands. Ulcers are classified not only on the basis of their mode of origin, but also according to certain peculiarities which are characteristic. Thus an ulcer may be healthy, fungous, erethistic, callous or atonic, phagedenic, etc. A liealtluf ulcer is one in which the granulations are small and florid and the edges show a bluish border of cicatrization. If it be small, it may be allowed to scab and cicatrize under the crust. If larger, carbolated oxide- of-zinc ointment, with or without calomel (3J@§j), with suitable protection by a bandao-e, and rest, is all that is needed as a rule. Simple avoidance of irrita- tion by means of a bit of "protective or gutta-percha tissue under an anti- septic dressing is often better than ointments. If slow in healing, stimulation by the occasional light application of nitrate of silver or a solution of chloral (gr. X @ ^j) or potassio-tartrate of iron (gr. v @ 5J) will be useful. Skin-grafting is required in large ulcers, and is now done early in many cases of large loss of tissue which would result in an ulcer at a later period. For the details of its application see the chapter on Plastic Surgery. If the granulations are too exuberant or are fungous, the application of the solid nitrate of silver, a solution of sulphate of copper (gr. i-x («; 3J), or shaving off" the exuberant granulations with a bistoury, followed by compression by Martin's rubber bandage or strapping or skin-grafting, will favor the healing of such ulcers. When the fungous granulations are pale and edematous, they may be due to tubercular disease, and in this case a thorough curetting of the surface should precede the application of caustic or actual cautery. The erethistic, irritable, or painful ulcer is a name applied to ulcers which are extremely sensitive. The cause of this sensitiveness is not always clear. They are found in regions liberally supplied with sensitive nerve-fibers, as the anus or matrix of the nail, and are then doubtless due to an exposure of the terminal nerve-branches in the w^ound. They are found frequently in the lower extremities about the ankle or over the surface of carious bone, as the tibia. Fissure of the anus is a good instance of this kind of ulcer, which by inducing constipation and other digestive disturbances often seriously undermines the general health. It is easily overlooked unless carefully sought for in the folds of the anal mucous membrane. It is best treated by forcible dilatation of the sphincter muscle. Ingrotving nail or ulceration of the matrix of the nail is due to irritation from a sharp corner of the nail, which should be removed. The local treatment consists of drying and soothing powders, such as iodo- form, or, better, the removal of the sensitive granulations with the curette 4 50 ^iV^ AMERICA X TEXT- HOOK OF SURGERY. or kiiitc imder cocaine anesthesia, and protection of the raw surface by daily packing a very small bit of absorbent cotton under the edge of the so-called "ingrowing" nail. It is really "overgrowing granulation" rather than " intrrowiim' nail." The calloH>i nicer is sometimes called indolent or atonic, and is due to a diminution to the minimum of the reparative process. The thickened edges are caused by the ineflectual attempts of the surrounding skin to form cicatricial tissue and epidermis. It is found in laboring and ill-nourished people, and is often due to the presence of varicose veins (varicose ulcers) or to eczema of the skin. Occasionally we find, as the result of long-standing disease and neglect in old people, a general hypertrophy of the affected leg, simulating elejjhantiasis. The treatment of such ulcers consists in rest in bed, elevation of the limb, and the employment of antiseptic or emollient dressings, and later perhaps skin-grafting. These ulcers are likely to recur unless support is given to the part b}' an elastic stocking or a bandage of flannel cut bias, or Martin's rubber bandage. When circumstances render it imjjossible for the patient to rest in bed, the ulcer may be treated by strapping with adhesive plaster, and a band- age made of some elastic material to give support to the blood-vessels of Fig. 17. riiroiiic rioers of the Legs. the limb. The strips of adhesive plaster should be an inch wide and long enough to encircle two-thirds of the limb, and should overlap each other from below upward like the clapboards of a frame house. Concentric incisions made through the indurated tissues around an indolent ulcer may relieve the cicatricial pressure on the circulation and enable the edges of the ulcer to cicatrize. The thickened margins, consisting of contracting cicatricial tissue, so inter- fere with the access of arterial and the egi'ess of venous blood that the foi-mation of healthy granulations is impossible. As much of the healing of all ulcers results from the reduction in size effected by the contraction of their bases, caused by the organization of the deep layers of the granulation-tissue into young connective tissue, rather than by epidermization, the fixation of the margins and base of a chronic ulcer to the subjacent parts must prevent healing. Upon this fact depends the utility of incisions a little distance from the margins of the ulcer. Blisters and the pressure of strapping owe much of their efl'ect to the removal by absorption of the constricting effect of the old cicatricial tissue upon the circulation through the ulcer. The j^hagedenic ulcer is due to infection by different forms of micro- organisms. When seen on the genitalia it usually follows venereal disease. In ULCERATION AND FISTULA. 51 other regions of the body it ma}^ be caused by constitutional conditions combined ■with unhealthy suiToun(lino;s. Jnteni])enince and scurvy are predisposing causes, and wlien individuals affected in this -way are crowded together in barracks or hospitals in time of war, such types of ulceration are not uncommon. The surface of the ulcer is devoid of granulations, and is covered with a mass of slougliing tissue. Its edges are sharply defined and appear as if eaten out, and it spreads with great rapidity. The treatment consists in curetting by a sharp spoon and removal of the overhanging edges by the knife or scissors, followed by a thorough disinfection of the part by the application of antiseptic agents, such as pure carbolic acid, bromine, sublimate solution 1 : 500, and, if these fail, in the use of the Paquelin cautery. Constitutional treatment by means of tonics and stimulants and favorable hygienic surroundings should be employed. In mild cases pure iodoform or aristol or cliloral (gr. x-xx (a^ gj), or the potassio- tartrate of iron (gr. v@sj), Avill often effect a cure. Ulcers depending upon specific origin, such as the strumous, scorbutic, lupoid, and syphilitic ulcers, will be considered more fully under their appropriate head- ings. The ulcerations seen in malignant diseases are chiefly carcinomatous. One of the most frequent forms is rodent ulcer, which is situated on the nose and cheeks, and often resembles specific or tuberculous ulcerations. It is, however, due to the breaking down of a genuine epithelial growth (Warren). Deep-seated cancers, when they reach the surface, enter upon an ulcerating stage, and may affect large surfaces in this way. Sarcomatous ulcers are com- paratively rare. SECTION II.— FISTULA AND SINUS. A FISTULA is an abnormal opening into a normal canal or organ — e. g. the rectum or the duct of a salivary gland — or a communicating passage between two adjacent mucous cavities — e. g. the bladder and vagina, etc. Such a fistula when it communicates with an unhealed wound or old abscess-cavity is usually called a sinus. The terms are often used interchangeably. There is a great variety of fistulse, each kind being named from the organ with which it commu- nicates. Fistulas may be due to congenital deformity, as a branchial fistula, •which is formed by the non-union of one of the branchial clefts. They may be the result of injury or sloughing, as the salivary or vesico- vaginal fistula. Si- nuses which result from the failure of an abscess to heal, and which have opened into some canal or cavity, are usually called fistulee, as the urinary fistula and fistula in ano. A SINUS is usually a canal opening upon the surface of the skin or a mucous membrane and terminating in the cavity of an old abscess. It may, however, result from the burrowing of pus beneath the skin, and will then form a tor- tuous series of canals extending in various directions. The failure of such a pus-cavity to heal is usually due to the presence of some secretion which pours into it, or to the pi'esence of a foreign body, as a piece of dead bone, or to the inability of the walls of the cavity to collapse and come in contact with each other, as in empyema or abscess in the spongy end of a bone. Frequently the diseased condition of the Avails of the sinus is an obstacle to repair. Many such sinuses are due to the presence of the bacillus of tuberculosis. In such cases they are lined with a membrane resembling that of cold abscesses, which must always be carefully extirpated or cauterized. The treatment consists, first, in the removal of all irritating or diseased substances. It is often necessary to lay the fistula fully open and thoroughly to curette its walls before healthy granulations Avill s])ring uj) and aid in the heal- ing process. Special fistulie will be considered under their respective regions. 52 ^^V AMERICAN TEXT-BOOK OF SURGERY CHAPTER VII GAXGRENE. Gangrene is a term employed to denote death of a part of the body in mass. Necrosis and mortification are terms used in a simihir sense, but in sur- gery necrosis is often limited to death of bone : it is applied also to death of internal organs where, owing to the absence of bacteria, putrefaction does not take place and the dead mass is absorbed, new tissue growing in from the sur- rounding healthy parts to take its place. Gangrene results either from a ces- sation of the arterial blood-supply or from an obstruction to the venous outflow, or purely from a stasis of blood in the capillary vessels. It may also take place independently of any disturbance of the circulation by the direct action of destructive agents upon the cells of the tissues. The most frequent non-traumatic cause of deprivation of arterial blood- supplv is a diseased condition of the arteries, such as is seen in senile gangrene. It mav also be due to arterial spasm, such as is produced by the action of ergot or disturbance in function of the vaso-motor nerves. Obstruction to the flow of venous blood is usually of a purely mechanical origin, as in strangulated hernia, or it may be the result of a venous thrombosis. Many causes act directly upon the tissues of the part, such as pressure, mechanical or chemical injuries, inflam- matory swelling, heat or cold, and bacterial infection. The state of the tissue, due to an impaired nutrition of the body, is often favorable to the development of wano-rene. This is observed during the progress of fevers or in individuals suffering from grave constitutional conditions, such as diabetes, or in parts deprived of their nerve-supply. , Typical gangrene occurs chiefly in two forms, the moist and the dry, which present striking contrasts to each other in their physical appearances. Dry gangrene (Fig. 18), or mummification, is a condition produced by the loss of water from the tissues. The skin becomes black and wrinkled, and is often of a leather-like hardness. The amount of decomposition which occurs in this form is very slight, and the dead part in typical cases causes but slight disturbance to the adjacent living tissues. In this form of gangrene there is a gradual diminution in the supply of arterial blood, while the outflow of venous Fig. 18. Dry Gangrene (original). blood continues unobstructed. In this way, aided by evaporation, water is gradually removed from the part. GANGRENE. 53 The most typical form of this variety is known as senile gangrene, due to arterial sclerosis, the result of an obliterating endarteritis or of atheromatous changes in the walls of the vessels, combined with feeble heart-action. The calcareous condition of the arteries can often be easily detected at the wrist. The circulation in the capillaries becomes very feeble, and a slight bruise suf- fices to produce permanent stasis. Senile gangrene usually occurs in the lower extremities, involving the toes, where the circulation is least vigorous. The tibial arferies are frequently the seat of an endarteritis which materially dimin- ishes their lumen, and a serious lessening of the blood-supply may exist in all the regions supplied by these vessels. The arterial blood may also be cut oft' by the presence of an embolus derived from valvular growths incidental to cardiac disease. In this case the disturbance in the circulation may occur so rapidly that mummification may not take place and moist gangrene will result. Dry gangrene may, however, be produced by embolism, and a large portion of an upper or lower extremity may occasionally be involved. Symptoms. — The disease usually originates in some slight injury, as the bruising of a toe or the tearing of a portion of the nail, and is recognized by the change of color in the part, the dark -red congestion which at first appears gradually assuming a purple hue. The surrounding tissues are deeply con- gested, and the boundary-line between them and the dead tissue is at first imperfectly marked. The gangrene slowly advances beyond the limits of the toe in which it originated, and the adjacent toes may also become involved. When the progress of the disease is arrested, the inflamed parts set up a barrier of granulation-tissue and the line of demarcation is formed. The suppura- tion which follows separates the dead tissue from the living, and a spontaneous cure may be eff"ected in this way. As the line of demarcation forms, the colors of the respective parts stand out in strong contrast. The inflamed tissues assume a brighter tint, while the purple hue of the dead part changes to black. An attempt on the part of the adjacent tissue to form a barrier to the advance of the disease often fails, and the gangrene spreads and may involve the whole foot, and even all the parts supplied by the tibial arteries. In the milder forms of the disease the amount of constitutional disturbance is slight, but when a large portion of a foot or leg is involved there is more or less septic infection, and a rise of temperature will indicate the presence of fever. This type is sometimes called uliopathie gangrene. The amount of pain is not great in this variety : during the early stages there may be a stinging or smarting pain, but after the formation of a line of demarcation this disappears. The pain in dry gangrene due to embolism is, however, much more severe, and generally is the cause of much intense sufiering. Occasionally obliteration of the arteries of internal organs may take place also, and infarctions Avith necrosis may be associated Avith senile gangrene. Moist gangrene (PI. VI) is caused by a sudden arrest of the arterial blood- supply or a similar obstruction to the return of the blood through the veins. It is likely to occur in deeply-seated tissues where evaporation cannot easily take place, as in strangulated hernia. Idiopathic gangrene may be of the moist type when the obstruction of the circulation is rapidly brought about and involves a large portion of a limb. Severely contused or lacerated wounds of the soft parts, or fractures com- plicated with laceration of the large vessels, are a frequent cause of moist gan- grene, known in this case as traumatic gangrene. Acute inflammations may be attended with such intense congestion and swelling that the circulation may be arrested over a considerable area, and death of the part will then occur. The same result will ensue from burns and frost-bites. In this form of fran- 54 ^.V AMERIVAX TEXT-BOOK OF SURGERY. grene — localized traumatic gangrene — tlie tissues become soft iuid jmlpy, the skin is discolored and clianges to a deep purple or black or is covered Avith green and black spots. A thin brownish fluid filters through the skin, and raises the epidermis in the form of blisters or exudes from the open surface of wounds. Decomposition takes place tlirough the agency of the saprogenic bacteria. In most cases a line of demarcation forms around the area affected by the destructive agency. There is. however, another form of traumatic gangrene — spreading traumatic gangrene — in which the disease extends with frightful raj)idity, due to an acute infectious process. These are cases in which the main artery or vein has been ruptured and the blood-supply of a portion of an extrem- ity is suddenl}' cut off, followed by infection. In other cases acute inflammation of severe type, together with the intense septic infection, produces the death of the part. The gangrene spreads rapidly, even hour by hour, up the limb. Acute putrefaction sets in and spreads through the agency of micrococci or bacilli. The changes in color are rapid and striking : a deep bronze hue, like rind of bacon, spreads rapidly along the line of extension of the disease, and is accompanied by streaks of green and black. The part feels dense and brawmy. The evolution of gas produced by the changes brought about by the putrefactive bacteria sometimes gives an emphysematous crackling to the sub- cutaneous tissue — a condition which is often observed somewhat in advance of the gangrenous changes. Constitutional disturbance is by this time very marked, and is due to the absorption of ptomaines, which the process of decom- position forces into the lymphatic channels and connective-tissue spaces or beneath fasciae or along the course of tendon sheaths. As the parts through which the gangrene spreads are beyond the point of injury, no opportunity offers itself for the escape of these chemical poisons, and they spread upward through the circulation. The result is septicemia of a grave type, from which the patient succumbs unless the progress of the gangrene has been arrested by amputation. This type of gangrene is sometimes known as ful- minating gangrene or gangrenous emphysema. Fortunately, such grave results do not always follow death of a part from trauma. The gangrene may be limited to the part the circulation in Avhich has been arrested, and a line of demarcation will soon separate it from the adjacent healthy parts. This form occurs frequently in a stump after amputation for railroad injury when the limb has not been removed at a point sufficiently remote from the seat of injury. A considerable portion of a limb may be destroyed by injury without a tendency of the gangrene to spread. In. this case the numerous lacerations permit an escape of blood and serum, and the conditions for the development and spreading of the intense forms of decom- position are less favorable. Smaller portions of dead tissue, such as the flap of an amputation-stump or masses of connective tissue or skin, are usually called sloughs. These are separated from the living parts by the septic inflammation which ensues and which results in suppuration ; and, as the wound cleanses itself and the sloughs are thrown off, healthy granulations are found covering its surface. Gangrene may residt occasionally from pressure, but unless the latter is excessive this occurs only in parts where the circidation is already feel)le and the conditions are favorable for complete stasis. Decubitus, or bed-sore, is pro- duced in this way from long rest in the recumbent posture in individuals debili- tated by fevers or long-standing chronic disease. When the slough has separated the ulcer thus formed may enlarge, and sometimes becomes quite formidable in size, and may be a complication more serious than the original disease. The H.-VI il' > ■"^^^ AMtmcftN (.rTHOoR«pmc«o Schullzc. pin •, GANGRENE FOLLOWING A SHOT LACERATION OF THE FEMORAL ARTERY. GANGRENE. 55 parts most frequently attacked are the integuments lying over the sacrum and coccyx, or, more rarely, the shoulder-blades and great trochanters. Sloughs may also be produced by bandages and splints wlien applied to a iVactured limb. A tVe(iuent seat of such a "splint-sore" is the posterior aspect of the heel or the skin covering the tendo A chillis. This form of local gangrene is much more likely to occur if the parts sub- jected to pressure have been deprived of their accustomed nerve-supply. Neuro- pathic gangrene, as it is sometimes called, is frequently observed after fractures of the spine. Sloughs Avill form "with great rapidity under the heels and sacrum. This predisposition to death of the part has been ascribed to a functional dis- turbance of the vaso-motor nerves or to an abnormal action of the so-called ''trophic nerves" which are supposed to preside over the nutrition of a part. A type of gangrene more clearly due to abnormal vaso-motor action is the symmetrical gangrene, or Raynaud's disease. This appears most fre- quently upon the tips of the fingers or the toes. It may also be found in various other parts of the body, as the tip of the nose, the cheeks, the knee, and other salient points where the heat of the body is less than in deeper parts. It is due to a spasm of the vaso-constrictors brought about by reflex action. It is extremely rare in America. The "cold finger" often observed in bathers is ascribed to a similar cause. In symmetrical gangrene the parts affected are at first the seat of abnormal pallor and numbness, then of a purplish dis- coloration, and a small slough finally forms which is thrown off and is followed by healing of the sore thus produced. Several fingers are simultaneously affected on both hands. A similar spasm of the vaso-motor nerves is produced by the prolonged use of ergot, and epidemics of gangrene have been observed in France and else- where which were due to the presence of ergot of rye (tSecale cornutum) in the grain employed as food. Individuals affected with diabetes are frequently attacked with diabetic gangrene. This is often seen in elderly people subjects of the disease, and may be mistaken for senile gangrene. The presence of sugar in the urine should therefore be carefully sought for. Operations upon such persons are supposed to be followed by gangrene or sloughing of the lips of the wound, and it is advised by some authorities to abstain from surgical operations if they can be avoided. A more extended experience with aseptic surgery, however, will probably not bear out this view. In one case known to the writer both legs were success- fully amputated for diabetic gangrene. There was an interval of one or two years between the two operations. Noma, or cancrum oris, is a gangrene of the cheek usually occurring in children as a complication of the eruptive fevers — e. g. scarlatina. It is the result of a gangrenous stomatitis, and is of bacterial origin, producing capillary thrombosis. The disease may even attack the bone, and in the majority of cases is fatal. If recovery takes place a large defect usually results which must be restored by a plastic operation. Gangrene from frost-bite may result partly from the intensity of the cold and partly from the enfeebled condition of the individual. The part at first is blanched, but subsequently turns black. It may assume the dry or the moist condition. It may be limited to the toes, which are the most frequent seat of this form of gangrene, or the whole foot may be involved. It is frequently quite superficial, and no attempt at surgical interference should be made until the line of demarcation is clearly established. Treatment. — The prophylactic treatment of gangrene consists in the removal, as far as possible, of the causes Avhich may favor the development of 56 AN AMERICAN TEXl-BOOK OF SURGERY. gangrene, and in the adoption of" such measures as uill promote the circula- tion of blood in the part. If inflammation threatens to terminate in gangrene, free incisions may relieve the tension sufficiently to avert the impending danger. Division of the constricting ring of a strangulated hernia Avill remove the obstruction to the circulation in the bowel. If, however, the obstruction cannot be removed, as in embolism or throm- bosis, attention must be given to the establishment of the collateral circulation in the limb by favoring as much as possible the flow of venous blood and preserving thewarmth of the part. Moderate elevation of the limb and gentle massage may favor the return of Itlood through the superficial veins. Slightly flexing the joints will favor the flow of blood through the larger vessels. An equable temperature of the desired degree may be maintained by enveloping the limb in dry cotton-wool, which should be loosely applied. Minute abrasions or sores about the nails in feeble individuals should receive careful attention, but meddlesome interference should be avoided, as these are frequently the starting-points of senile gangrene. If death of the part is unavoidable, great care should be taken to prevent infection and decomposition. The gangrenous part must be disinfected witli the same care as for an operation, and then be kept dry and odorless. Antiseptic dressings containing powders, as iodoform, boric acid, or aristol, should be applied. If the fluid products of decomposition are retained beneath the surface, they should be released by incisions into the gangrenous tissues, or if pus is bur- rowing, openings should be made into the living tissues to evacuate it. It was at one time the almost universal custom to wait for the line of demarcation to form in senile gangrene before making any attempt to remove the dead mass, and as a rule it is better to adopt this plan. If the gangrene shows a disposition to localize itself, it would be bad practice to interfere in any way Avith the processes that are going on in the enfeebled living tissues, as any disturbance of them might cause the gangrene to spread still farther. As soon as the gangrene involves the sole or the dorsum of the foot, the question of amputation will become one of vital importance. In determining the point at which to amputate the pathology of the disease should be kept in mind. If we have to deal with a disease of the tibial arteries, it will be necessary to decide at what point in their course the circulation is of sufficient volume to maintain the life of the stump. Never amputate low down. Heidenhain recommends amputation of the thigh as close above the condyles as possible. An amputation of the leg below the tubercle of the tibia in some cases may be sufficiently high, but generally it is necessary to remove the leg at or above the knee. The latter point is often to be preferred, since the flaps will then be largely nourished by branches of the profunda femoris, which is rarely thrombosed. A considerable number of cases which in former times were allowed to die without surgical interference are now undoubtedly saved by amputation. In gangrene from embolism amputation should be performed well above the gangrenous area as soon as the extent of the gangrene has been determined by the establishment of a line of demarcation. In traumatic gangrene involving portions of the integuments it is not necessary to attempt removal of the sloughs until the line of demarcation indicates clearly the extent of the injury. A partial removal of the dead skin may, however, favor drainage of the parts below. When a portion of a limb is destroyed by injury, the question of an imme- diate amputation should first be carefully considered. If this is not done and GANGRENE. 57 gangrene sets in, and there are any signs of its spreading, this should prompt the surgeon to urge the necessity ofainputiition. If the gangrene is localized, the general condition of the patient "will enable one to decide whether it is best to remove the dead portion of a limb immedi- ately or not. The effect of the presence of such a putrescible mass must be weighed against the danger of an operation in a patient suffering from shock and possibly other severe injuries. The conditions of each case will enable one to decide whether it is better to remove the limb at the line of demarcation or to amputate through sound tissue. In spreading traumatic gangrene it will of course be necessary to amputate instantly and tar away ; that is, sufficiently high to remove all tissues involved in the septic process. There is perhaps no atlection in the whole domain of surgery which demands such prompt interference in order to avert impending death. The constitutional treatment consists in attention to the condition of shock and in supporting the strength of the patient. Absolute rest, careful nursing, and a diet that will be nutritious without interfering with the digestive func- tions will best meet these indications. Alcoholic stimulants are also of great value and should be used freely, but with due regard to the patient's powers of assimilation. The treatment of bed-sores is largely prophylactic by frequent change of posture, and — thanks to the present system of nursing — the attention of the physician or surgeon is now rarely called to this affection. Dry dressings are to be preferred, as moisture favors the enlargement of ulcers produced in this way. Mechanical support to relieve pressure and strict attention to antisepsis will usually arrest the progress of the disease. The rules for the treatment of diabetic gangrene vary but slightly from those laid down for senile gangrene. The disease is not necessarily a contra- indication to amputation. In any event a most careful attention to the diet will form an important factor in the prognosis of the case. Little operative interference is necessary in symmetrical gangrene: the main points in the treatment of such cases are attention to the diet and hygienic surroundings and the administration of tonics. Hospital gangrene is one of the traumatic infective diseases, and is characterized by a septic inflammation of the surface of a wound, causing ulceration and the formation of sloughs, and is accompanied by more or less constitutional disturbance. The disease at the present time has almost com- pletely disappeared, oAving to the general employment of aseptic and antiseptic treatment. It formerly occurred when patients were crowded together in small quarters with insufficient attendance and food and under poor hygienic condi- tions. The principal varieties usually described are the diphtheritic, the ulcer- ating, and the pulpy forms. The disease has been regarded by some as iden- tical Avith diphtheria, but, as the latter disease has continued its activity for twenty years after gangrene has disappeared, this assumption does not appear probable. No bacteriological studies of value have been made, but some writers report large numbers of streptococci, and Koch produced in mice a disease resembling hospital gangrene in which the streptococcus was found. The diphtheritic form is characterized by the occurrence of coagulation- necrosis in the granulations. There is, moreover, less inflammation in the mar- gin of the wound in proportion to the depth to which the tissues are involved. The discharge is at first diminished, but later becomes more watery in char- acter, the sloughs separate, the wound has a crater shape, and its edges are eroded. In the ulcerating form there is a progressive enlargement of the 58 AN AMERICAN TEXT-BOOK OF SUROERY. wound, cliielly on tlic .surface, accompanied by an unhealthy or grayish dis- coloration of the granulations. The edges break down, recede daily, and have a gnawed look, and the wound may finally become very large. This type is sometimes called pliagedcna. 'Die j)ul|)y form is more common in epidemics. The granulations swell, become oedeiuatous and necrotic, the surface of the wound is soon enormously swollen, and a fetid discharge wells up in large (}uantities from its depths. Its margins become swollen, everted, and are ex(iuisitely sensitive. There are great discoloration and swelling of the surrounding parts, with profound constitutional disturbance. The wound increases in size with great rapidity, and secondary hemorrhage often occurs. Joints are laid open and muscles dissected out as the disease spreads, and if the disease is not arrested, the ])aticiit finally succumbs to se[)ticemia. The prophylactic treatment consists in the application of the rules of aseptic surgery, and when, as in time of war, these cannot be observed with sufficient care, in avoiding the accumulation of great numbers of patients in confined ((uarters and their prompt isolation if the disease appears. Tiie local treatment consists in a thorough disinfection of the surface of the wound and the surrounding infected tissues. This may be accomplished by removing the diseased tissue with the curette or scissors, and by the sub- sequent application of the cautery, bromine, fuming nitric acid, or acid nitrate of mercury. The operation will require anesthesia, as even the ordi- nary dressing of such a wound is exceedingly painful. For milder cases a weak solution of nitric acid may }je used with advantage, or the wound may be freely dusted with iodoform. Perchloride of iron was used with success by the French in their last war. Whatever the agent employed, it must be applied as directly as possible to the living tissues. The constitutional treatment consists in the free use of stimulants and supporting diet. An entire change of the patient's surroundings may bring about a prompt improvement. Epidemics have been broken up by moving the patients from the wards of a hospital into tents. All clothing and bedding and dressings should be changed at the same time. Amputation may be sometimes called for, and can be successfully done under strict antiseptic precautions. The disease being distinctly contagious, isolation and the non-use of sponges, towels, basins, etc., from patient to patient, are evidently necessary. CHAPTER VIII THROMBOSIS AND EMBOLISM. A THROMBUS is a clot of blood Avhich forms in the blood-vessels during life. An embolus is a detached fragment of a thrombus, a fragment of a vegetation on one of the valves of the heart, a globule of fat or of air, etc., which has been transported to some other part of the arterial system and acts as a plug. Coagulation of l)lood may take place in one of two ways : "When blood is allowed to remain stagnant in a fiask, the clot which forms is nearly as large as the whole amount of blood, and is of a deep-red color, which still remains after the serum has been pressed out. It contains chiefly red corpuscles held together by fibrin. It is such a clot that is found in the red thrombus. The clot from blood beaten with a stick loses its red color, and is of a yel- Tl[h'()}riiOSIS ANJ) KMliOIJSM. 59 Fk;. 19. lowisli-wliite tiiifje, consisting of a tough mass of fibrin containing' but few red corpuscles. As has been shoAvn else^vhere, this coaguluni contains chiefly broken-(h)wn white corpuscles which have yielded up their fibrin-j)roducing material. This is one way in which a w/iifc thnnnbuH is formed. Coagulation appears to be due to slowing of the current and also to roughness of the inner wall of the vessel, to injury to the wall of the vessel, or to septic infection. A thrombus usually forms in a vein, but it may also form in the distal portions of the arterial system and in the heart. After a thrombus has formed it may undergo several changes. It may become organized, young tissue growing into it from the vessel-wall and forming cicatricial tissue. As portions of the clot are disintegrated and absorbed spaces are h^ft, and the thrombus is then said to be canalized. Blood flows through these channels, and the circulation is in this Avay partly re-established. At other times the fibrin and leucocytes break up and form a slimy fluid, which is swept away and the thrombus disappears. When sep- tic infection takes j)lacc the thrombus is said to undergo a " puriform softening." A thrombus thus disorganized may break into fragments, which become detached and are swept into the circulation as infective .emboli. Such thrombi are often found in the cerebral venous sinuses or in the large veins of the extremities in septic inflammations. A thrombus once formed may grow by addi- tions of coagulated blood, and, when it has devel- oped so as to project into a large vessel, a por- tion of the protruding clot may become detached and give rise to embolism. Pulmonary embo- lism, a fatal complication, is produced in this way, and may follow phlebitis or capital opera- tions, such as hysterectomy. Very small emboli may pass through the lungs and enter the arterial system. Emboli are found in the arteries and also in the veins of the liver. When an embolus is lodged in a terminal" artery^ the part sup- A Thrombus in a Vessel. The de- tached fragment about to be carried away in the direction of the blood-stream is an em- bolus (Billroth). plied by this vessel is deprived of its circulation and becomes anemic, or occasionally a backward flow of blood takes place from the veins into the emptied vessels and a congestion with extrava- sation or a "hemorrhagic infarction" occurs. If the embolus is an infected one, suppuration will take place and a metastatic abscess forms. Emltoli which are detached from the endocardium are lodged in the peripheral portions of the arterial system. Those found in the brain are of little practical interest, as they produce conditions not amenable to surgical interference. Emboli are occasionally arrested in the arteries of the extrem- ities, and produce that form of gangrene known as embolic gangrene. Such emboli are found in the brachial arteries or one of the arteries of the fore- arm ; but more often in one of the tibial arteries. When a large vessel is thus plugged a thrombus begins to form upon the proximal side of the em- ' Terminal arteries are arteries without anastomoses, and are found in the brain, lung, spleen, and kidney. 60 .l.V AMKRICAX TEXT-BOOK OF SURGERY. bolus, and often extends a long distance toward the main trunk, tims increas- ing the extent of the gangrenous area. Thrombi are also occasionally found in the terminal portions of the diseased arteries of aged or infirm individuals, and may give rise to gangrene. Embolism of a mesenteric artery may give rise to gangrene of the intestine ; but if the embolus is small enough to find its way into one of the intestinal branches, no serious results may be feared, as the anasto- mosis is very free. Thrombosis of the mesenteric veins occurs as the result of marasmus, cirrhosis of the liver, or thrombophlebitis. Elliot successfully removed four feet of intestine which had become gangrenous from this cause. The treatment of thrombosis or embolism is mainly prophylactic. Care should be taken that the thrombus does not give rise to emboli. The part therefore should be kept at rest until organization or absorption of the thrombus has taken place. The danger of embolism from thrombosis usually ceases about three weeks from the time of the development of the thrombus, as the clot by this time has become firmly adherent to the vessel-wall. When an artery of an extremity has been plugged the limb should be kept warm : no constricting dressings should be applied, and every oppor- tunity for the establishment of a collateral circulation should be given. CHAPTER IX, SEPTICEMIA. Septicemia is a disease due to the absoi-ption of the products of putrefac- tion into the system, or to the introduction into the blood and tissues of bacteria which rapidly multiply there. It is characterized by grave constitutional disturbance, with acute fever, disorders of the nervous system, inflammation of certain viscera, and a local infection of the wound. The nature of the poison which produces the disease is not yet fuUy understood. Experiments on animals have .shown that there are two varieties of this form of blood-poisoning. In certain cases .symptoms supervene immediately upon the inoculation, and the animals die of a chemical poison, no bacteria being found in the blood or tis- sues (sapremia, toxemia, or septic intoxication). In other cases the symptoms come on le.-s rapidly. anrtt'(l. particularly in the chronic forms of the disease. Treatment. — The prophylactic treatment consists in the prevention of suppuration. The antiseptic treatment of wounds has almost abolished the disease in hospitals, where it was formerly of frecjuent occurrence. When the first septic disturbances have developed in the wound and adjacent veins an attempt should l)e made to arrest the further progress of the disease by a thorough disinfection, not only of the wound, but of the interior of the vein. Such attempts liave been successfully carried out in thrombosis of the lateral sinuses and jugular veins following suppuration in the mastoid cells. If the interior of the vein cannot be th(ti'oughly disinfected, a ligature may be placed upon it at a point between the puriform thrombus and the heart. When the infected area is seated in an extremity amputation may be performed, provided the surgeon can be reasonably certain that the thrombus does not extend above the point selected for the operation. When it is possible all metastatic ab- scesses or suppurating joints should be laid open and thoroughly disinfected. Drugs are of little use in the internal treatment of the disease. Anti- streptococcic serum has been advocated and tried, but its usefulness is still in doubt. Antipyretics depress the hearts action. Carbonate of ammonium and digitalis are more likely to be of service during the stage of prostration. Alcohol should be given freely, and in as large quantities as the patient will bear. Easily-digested food should also be administered unsparingly. If the patient is in a hospital, he should be immediately isolated from all other patients, and as strict a quarantine as possible of those in attendance should be preserved. Ventilation should be free, and the patient may be placed in a tent, or even for a portion of the time in the open air, in certain cases. CHAPTER XI, ERYSIPELAS. Erysipelas is an acute infective inflammation spreading along the upper layers of the integuments of the body and mucous membranes tlirough the lymphatic system. It is accompanied by a remittent type of fever and shows a tendency to recur. The name is probably derived from ioo&oo^, red, and TrikXa, skin. Erysipelas was known to the ancients, but authentic accounts are of comparatively recent date. Severe epidemics of erysipelas raged in France in 1750. in Great Britain in 1800, and in 1842-43 both Europe and America were visited by an epidemic of a most virulent type. Since then there are no records of epidemics of similar severitv. Although much less frequently met with since the introduction of the antiseptic treatment, it is the most common of the traumatic infective diseases seen at the present time. Etiology. — The organism Avhich is the cause of the disease is the strepto- coccus erysipelath. This has been abundantly proved by experiments in ani- mals and man. Opinions vary as to the identity of the streptococcus pyogenes with the streptococcus of erysipelas. The cocci grow in serpentine chains ; each measures from 0.3 to 0.4 micro-millimeters in diameter. These cocci are said to be somewhat larger than the streptococcus pyogenes, but smaller than the staphylococcus. They are found in the capillary lymphatics of the ERYSIPELAS. 67 skin cliielly, but tliov may also be seen occasionally in the capillary blood- vessels, 'riiey are most active near the marpeared during an attack. Lympho-sarcoma of the neck has been absorbed, tiie cells having uiulergone fatty degeneration. Both lupus and epithelial ulcers of tlie face have been known to break down, healthy granulations su))sequently appearing which healed rapidly. Fehleisen took advantage of this circum- stance to inoculate certain ulcers with cultures of the streptococci of erysipelas, and thus demonstrated the identity of the virus of the disease (p. 207). '^\\Q prognosis of erysipelas is usually favorable, as there is a tendency to self-limitation. The severity of the disease cannot, how^ever, be predicted in any given case, but in small granulating wounds the disease is usually lighter than in large fresh wounds. Danger frequently arises from complications, as oedema of the glottis or secondary hemorrhage. Treatment. — Attempts to restrain the infective process by antiseptic applications have thus for not been very successful. The apparent success of many drugs may be due to the spontaneous arrest of the process which so often occurs. Hot fomentations, containing corrosive sublimate of the strength of 1 : 10,000 or 1 : 15,000, or carbolic acid may be used ; but care must be taken to avoid increased local irritation or poisoning by absorption of the drugs when a large surface is covered. An ointment of carbolic acid and vaseline, 1 to 100, may be brushed on the face with a soft brush or applied to other surfaces and protected with a thin layer of gutta-percha tissue or oiled paper. Zinc ointment, or an ointment of ichthyol (25 per cent.), is often useful. In phlegmonous erysipelas free incisions are indicated. The slough should be removed, and the pus-cavities must be disinfected as thoroughly as possible. Pressure with plasters or bandages in situations where they can be conveniently applied, has been advised to arrest the spread of the disease. The constitutional treatment should always be supporting, and any deplet- ing measures should be carefully avoided. The presence of delirium does not necessarily contraindicate the use of stitnulants. Tincture of the chloride of iron has been recommended in large and frequent doses on account of its action upon the red blood-corpuscles, which are found crenated, and when placed under the microscope run together readily. This method was at one time received with great favor, but is less used at present. Quinine has also enjoyed a great popularity. Antipyretics as a rule have little effect upon the fever, and should be avoided, owing to the depressing influence upon the heart's action which many of them exert. Opium in some form and hypnotics are indispensable to allay the pain and procure sleep. Food should be carefully and frequently administered. When the blush has disappeared a complete change of bedding and clothing, with careful disinfection, may serve to pro- tect the patient from a relapse due to a reinfection of the system. 70 .l.V AMKIUCAX TKXT-nOOK OF SLlKiEUY. CHAPTER XII. TETANUS. Tetanus is an infective disease, almost always originating from a wound. The central nervous system is the region chiefly affected by the bacterial poison which is the cause of the disease. The bacillus of tetanus (PI. IT, Fig. T)) was discovered in 1885 by Nicolaier. It is a siiort rod with an enlargement at one end. due to sporulation, which gives it the characteristic drumstick shape. Although it is found in the dust of the street, it rarely finds an opportunity to grow in the living ti.ssues, owing to its anaerobic properties ; hence the rarity of the disease. It is found principally in the tissue near the wound, and is rarely, if ever, seen in the internal organs or blood. Several ptomaines have been extracted from the cultures of this bacillus, such as tetanine and tetano-toxine, and it is probable that most of the symptoms of irritation of the nervous system are due to the presence of these substances, as but few bacilli are found there. Punctured wounds naturally offer the best opportunity for the growth of the anaerobic bacillus, and if such wounds are inflicted in dirty parts of the body, as the hands or feet, or foreign bodies covered with dust containing the bacilli are lodged in the tissues, the conditions favorable for infection are obtained. The state of the weather is said to have an influence upon the development of the disease. It has appeared in epidemic form with sudden changes in the weather after battles. It is also said to be much more common in tropical climates. Tetanus is said to be traumatic or idiopathic. It is probable, however, that all cases of tetanus are traumatic, but tliat the wound is so slight in many cases as to escape notice. It has been known to follow such injuries as simple fracture, in which case internal infection probably occurs. Acute tetanus most fre((uently makes its appearance at the end of the first week after the infliction of an injury, although tliis period varies considerably. The first symptom complained of is a stiff neck, which the patient attributes to a slight cold. The muscles of the face and jaw are next involved, and the patient is unable to open his mouth, this symptom giving rise to the popular name " lock-jaw." The muscles of the fauces and the pharynx are often in a state of spasm, rendering deglutition difficult. The muscles of the thorax and abdomen are next involved, and the muscles of the back are so painfully contracted that the head is thrown l)ack, the spine is arched, and the body assumes the position known as opisthotonos. The lower extremities may also become rigid ; the arms are, hoAvcver, only partially affected. The muscular spasms, which are tonic, permit of little rest, and the sufferings of the patient are excessive and almost continuous. The expression of the face is totally changed by the contraction of the various muscles, which jn-oduces the characteristic risus sardonicus. The patient often experiences considerable difiiculty in passing urine or in having a movement of the bowels. Any dis- turbing influence, especially noise, instantly evokes the muscular contractions and adds to the patient's sufterings. These have been known at times to be so severe as to produce rupture of a muscle or fracture of a bone. Such a condition permits of little sleep, and in the acute cases the patient rarely obtains any rest from the moment the disease makes its appearance. The temperature is usually not much elevated, but the skin is bathed in perspira- tion. The pulse is weak and rapid, and as the disease progresses the exhaus- tion becomes marked, owing to loss of food and sleep. Sudden death often TiyrAxcs. 71 occurs in :i jKiroxysm of dysj)iieii. The niiiid is usually clear to the last. Such an attack will run its course usually in two or three days. In chronic tetanus the disease makes its appearance at a later date. The muscles arc extensively involved, but there are ])eri()ds of comparative relief, and as these intervals become ( n< <)isii;(;i:in'. product is calcified. If, however, the process extends, the caseons nodule becomes laro;er, the necrosed material breaks up into a granular d(''bris, and a fluid is produced which in appearance resembles true pus. These products of degeneration frequently contain the bacilli, and when inoculated into animals may re])roduce the disease. This tuherruIouH pus or puruloid material contains the broken-down masses of cells and a certain numl)er of leucocytes and fragnu-nts of the coagulation- necrosis. The contents of cold abscesses arising from tuberculous processes are usually of this character, but occasionally the pyogenic organisms are found in this fluid, in which case true suppuration occurs. The tubercular pus is thin and of a peculiar white or chalk-like color: it contains lumps of cheesy matter the product of tubercular softening, and fragments of sloughs of the connective tissiu'. Crumbs of bone may occasionally be felt in it. If the tubercular nodule is on the surface of the skin or a membrane, such degenerative changes will lead to ulceration. The local spreading of tubercular inflannnation is caused by the growth of the bacilli, Avhich involve new areas of tissue. Adjacent cavities or organs mav thus be invaded. By the breaking down of bone-tissue the bacilli may gain an entrance into a joint, or the peritoneum may become infected from a tuberculosis of the intestine. When the bacilli enter the blood-vessels or lymphatics, they may be transported alone, or in the interior of small emboli, to a distant organ, and a general miliary tuberculosis may be thus produced. Tuberculosis is probably the most common of all diseases, for it is estimated that IS per cent, of all cases of death occur from this cause. According to Baumgarten, it arises more frequently by inheritance than in any other way ; but, although the bacillus may undoubtedly ])e transmitted from parent to off- spring, it is probable that only a predisposition to the disease is the more fre- quent result of heredity. The disease easily arises then in such predisposed persons when the bacillus gains an entrance to the body through the respiratory organs, Avhether inhaled with the air as dust arising from dried sputa and other excretions, or taken into the alimentary canal with food and penetrating the intestinal mucous membrane. It may also be introduced through wounds of the skin, chiefly of a trifling character, such as bruises or scratches. It is undoubtedly an infectious disease, and may be contracted by persons of healthy ancestry by continued exposure to its germs. Tiiherculosis of the skin includes a number of diseases which until recently have been regarded as diff'erent aflcctions. The most frequent form is that known as lupus. This disease is now recognized as a lesion due to the pres- ence of the bacillus of tuberculosis, although it is often extremely difficult to find the organism. The tendency of the disease is to remain local, but it may occasionally lead to a general tuberculosis. Lupus vuJ(/an's is most frequently seen on tlie face, but other portions of the body may be the scat of the affection, particularly the extremities. It is characterized by a chronic inflammatory process, forming brown-red nodules with a tendency to ulceration and sul)se- quent cicatrization. In this way a considerable area gradually may be involved. When the tendency to ulceration is excessive we have the form known as lupus exedens, although this name is often given erroneously to ulcerating forms of cancer of the face. In other cases the amount of granulation-tissue may be a prominent feature, and then we have the form known as Jup}(s hi/pfrfropJu'eus. When there is a tendency to the formation of cicatricial tissue the disease may produce exten- sive superficial alterations in the skin, and give rise to great deformity, the TUBEJicrLOSIS. 77 whole surface of the face bring occasionally involved. l*atients with lupus not infre(iuently die of pulmonary tuberculosis. The aft'ection known to surgeons as anatomical tubercle, and frequently found on the fingers and hands of assistants in the autopsy and dissecting rooms, is now recognized as tubercular, and is regarded as almost identical with the variety known chietly as tuberculosis verrucosa cutis or verruca necrogenica. It is characterized by plaques situated chiefly on the backs of the hands, arms, and fingers, looking at first sight like a cluster of inflamed warts. There are also erythematous patches and pustules. Scrofuloderma is a name applied to certain tuberculous affections of the skin which formerly were not regarded as allied to lupus. It occurs as a more or less deep-seated, chronic inflammatory process in any part of the skin, prefer- ably on the neck, body, or extremities, and shows a tendency to the formation of granulation-tissue, which breaks down and gives rise to sinuses or minute ulcerations. It is occasionally associated with disease of the lymphatic glands and bones. It is sometimes called scrofulous gumma, owing to its resemblance to syphilis. Primary tuberculosis of the panniculus adiposus is observed, particularly in children, in the form of flat subcutaneous nodules which gradually soften and break down and discharge. In some cases they may burrow extensively with- out coming to the surface- Tubercular abscesses of the deeper connective tissue are, however, usually secondary to some affection of the bones or joints or lym- phatic glands. The larger abscesses, generally known as cold abscesses, originate most frequently from tuberculous disease of the bones. Such cavities, when opened, present a characteristic appearance. The walls are covered with a membrane of a grayish-yellow or grayish-red color, which is loosely attached, and can readily be removed with the finger or sharp spoon in large fragments. It consists of a very soft and slimy material, which con- tains great numbers of miliary tubercles closely packed together and imbed- ded in masses of fibrin. AVhen scraped away healthy tissue is exposed. At one spot the persistence of a small islet of granulations indicates the opening of a fistulous track which leads to diseased bone. Occasionally no such fistula can be found. This is the case in the so-called peri- or para-articular abscess when the septic infection of the connective tissue is transmitted from a diseased bone or joint through the lymphatics. Such abscesses, although at first not communicating with the affected joint, may later establish an opening into it. Fistulse leading to tubercular abscesses are also lined Avith a tuberculous mem- brane. The pus of these abscesses may contain a few leucocytes, but consists chiefly of the products of caseous degeneration. The presence of the bacilli of tuberculosis, although not easily determined with the microscope, is often demonstrated by experimental inoculation in guinea-pigs. In the tyj^ical cold abscess pyogenic cocci are not usually found under the microscope, nor can they be obtained from cultures of this pus. The absence of fever in cases where these large abscesses are found is thus explained, and the constitutional dis- turbance which frequently follows the opening of a cold abscess is undoubtedly due to a subsequent additional infection with the pyogenic cocci. Adjacent muscles are rarely infected by tubercular abscess: it is now well understood that striped muscular fiber is not liable to tuberculous disease. Tuberculosis of the mucous membranes may follow or accompany lupus of the skin. A direct extension may take place from the alae of the nose or from the lips to the nostrils, gums, or pharynx. Tuberculosis of the tongue is a comparatively rare affection, and is liable to be mistaken for cancer or syphilis. It appears as a chronic inflammatory pro- 78 AN AMEJIICAX TEXT-BOOK OF srUdKRV. cess Avhicli produces an infiltration extending to the dee|)er muscular tissue. On the surface ulceration may take place. It may he associated Avith tuhercu- losis elsewhere, and the presence of pulmonary signs or fistula in ano ■would serve as aids to diagnosis. The prognosis will depend largely upon the general condition of the patient. Lupus of the vcluiii, totis/Ls, and pliarjpix is often found associated with lupus of the skin, and, according to Lennox IJrowne, is more likely to be seen in skin than in throat clinics. It appears in the form of numerous suj)er- ficial ulcerations surrounded l)y inflamed and thickened borders, which show a tendency to become confluent. There is less loss of substance than in syphilitic lesions of these parts, as the ulcer tends to cicatri/-e. The adjacent mucous membrane is often found studded with miliary nodules, which run together, break down, and form new ulcerations. The miliary tubercles are situated immediately beneath the epithelial layer, and may also involve the intermuscular and connective tissue. The giant-cells are numerous and well developed; the number of bacilli is, however, usually small. Many of the patients wlio are the subjects of these affections succumb to pulmonary tuber- culosis. Tuberculosis of the throat or lungs may give rise to tubercular disease of the intestinal canal. As a result of such infection ulcers may form in the neighborhood of the caecum and appendix, and may perforate the bowel and give rise to a tubercular abscess. Tubercular inflammation of the large intestine has been known to give rise to so much obstruction as to necessitate laparotomy, which has been successfully performed. The development of tubercular peritonitis from this source is supposed to be much less common than from the Fallojiian tubes. Most cases of fistula in ano are tuberculous. They are characterized by the formation of fungous granulations and a tendency to burrow beneath the skin and mucous membrane. In many of these cases symptoms of pul- monary disease are also present, and the prognosis is then exceedingly unfiivor- able. All portions of the f/enito-urinari/ tract appear to be affected by tuber- culosis. Lupus is found occasionally on the labia majora. Cornil has found the bacilli in ulcerations of the vagina adjoining a vesico-vaginal fistula. In six autopsies of cases of tuberculosis of the uterus he found in three a number of bacilli. Tubercular infection of the Fallopian tubes often supervenes upon a clnonic catanlial salpingitis in cases of tubercular disease of other portions of the genital mucous membrane. It is possible that infection of the female o-enital organs may result from coitus, as the bacilli of tuberculosis have been found in the semen of tuberculous men even in cases where the genital organs are not the seat of tuberculous disease. Tuberculous peritonitis not infre- quently accompanies tuberculous pyosalpinx. Tuberculosis of the mamma is rare. Tuberculous ulcerations or sinuses may occasionally be seen about the nipple, and yield readily to treatment. Several cases are reported by Cornil where miliary tubercles containing giant- cells and bacilli were found in the ducts of the gland. Tillmans recommends, in every case of tuberculosis of the mamma, extirpation of the breast and the lymphatic glands. Tuberculosis of the 7nale genital organs has usually an unfavorable prog- nosis. Tuberculosis of the testicle occurs most frequently in early adult life. Many cases of cure occur without operative interference, although there is danger that the disease may propagate itself along the course of the vas deferens to the vesiculae seminales, the prostate, and the bladder if the testicle TUBERCULOSIS. 7!) is not removed. Tubercles are found in tlic uictlii;!, in llie nienibninous por- tion chiellvi but the disease is more fre(iuently described as existing in the bladder. It nuiy at times be quite extensive and involve the kidneys. It is one of the most difficult forms of the affection to deal with, and early diagnosis by detection of bacilli in the urine is therefore important. The tubercular affections oi' bones are found most frec^uently in the vascular spongy tissue of the epiphyseal ends of the long bones. Tuberculosis of the shaft of' the long bones is comparatively rare. The disease is found in the short spongy bones, as the bodies of the vertebraj and the bones of the tarsus and carpus. It is also seen occasionally in the fiat bones, as those of the skull and the pelvis, the orbital portion of the superior maxilla, and the ribs. In the epiphysis the tuberculous nodule is usually formed some little distance from the cartilage. On section of the bone one sees, in the beginning of the disease, a yelloAvish-'white or pure yellow well-defined mass lying in the spongy tissue, which even with low powers can be seen to be made up of miliary tubercles, some of them already in a state of cheesy degeneration. As this nodule grows in size it becomes softened, and finally forms a cavit}'^ containing a more or less softened material mingled with minute fragments of bone ; or the degenerated bone becomes necrosed in a mass and forms a sequestrum. This is generally of a roundish form and frequently as large as a walnut, and is surrounded by a layer of granulation-tissue which is also infected with tubercle bacilli. More rarely the tuberculous nodule may break down and form a small abscess. Such pus-cavities are most often seen in the extremities of the tibige. Occasionally the nodule may remain for a long time unaltered, and is then surrounded by a dense capsule. Sclerosis or eburnation of the surrounding bone may occur under these circumstances. The bacilli reach the epiphysis usually through the circulation. They are most frequently conveyed there as single organisms floating in the blood, but they may be transmitted in emboli, possibly from a tubercular mass in the bronchial glands. If such an embolus should plug a terminal arteriole, an infarction of the bony tissue may result, forming a wedge-shaped sequestrum with its base directed toward the joint and the apex pointing toward the diaphysis. These Avedge-shaped tubercular infarctions have been produced experimentally in animals by injecting tuberculous pus into the tibial artery. It is possible that a growth of granulations may invade the tubercular mass, and that complete absorption may take place ; and the part may be thus restored to its normal condition. Even a tubercular seques- trum may be disposed of in this way under favorable conditions. Usually, however, the nodule softens and the tubercular pus breaks into the joint or into the adjacent connective tissue. When the joint is involved, tubercular infection of its surface will occur and disorganization will probably take place- When the pus discharges through the periosteum, a cold abscess will form which may burroAv extensively and finally break externally. Tuberculous osteomyelitis of the shaft of the long bones occurs chiefly in the phalanges of the hands and feet. The disease appears first in the marrow, which with the cortical bone is changed into granulation-tissue : at the same time the periosteum is stimulated into a new bone-formation, which in its turn becomes involved. In consequence of these progressive changes the bone is much distended in the middle of its shaft, the so-called spina ventosa. The disease may undergo spontaneous cure or suppuration may take place. Con- siderable deformity may be caused by atrophy of the affected bones in early life. Tuberculosis is also frequently observed in the short spongy bones, par- ticularly in the bodies of the vertehroe, giving rise to Pott's disease, and in the bones of the carpus and tarsus. The changes produced in bone-tissue by 80 AN AMKUICAX TEXT-BOOK OF SURGERY. the bacillus of tuberculosis is that known hitherto as caries; that is, an absorp- tion of the bony tissue, giving it a worm-eaten appearance. Necrosis is more freciuently the result of acute inflannnation produced l)y the ])resence of the pyogenic cocci, but, as we have seen, it may occasionally be due to the action of the bacilli of tuberculosis. Tuberculosis of the joints (known often as white swelling, tumor albus, hip disease, ankle disease, etc.) usually results from infection by the opening of a primary nodule from the bone into the joint. A primary tuberculosis of the synovial membrane, however, may also occur. As the consequence of infiltra- tion with miliary tubercles we find a thickening of the membrane with forma- tion of granulation-tissue which may not be accompanied by any collection of fluid in the joint. At other times there is considerable turbid or bloody fluid, or suppuration may take place and the joint contain the characteristic thin and pale tubercular pus. AVhen the tendency to the formation of granulation- tissue is excessive, the condition known as caries sicca exists. Little or no pus is formed, but there is extensive loss of bone as the result of caries. Occasionally circumscribed tubercular nodules form on the synovial membrane and project into the joints as small pedunculated tumors, consisting of fibrous tissue, but containing a softened tuberculous mass in the interior. In the serous form of tuberculous synovitis numerous '■'rice bodies'' or '■'melon-seed" bodies are seen in some cases, either free in the joint or attached to the capsule by a pedicle. They are composed of concentric layers of fibrin, a substance which is so often associated with the formation of tubercles. As the disease progresses the articular cartilage is attacked by the granu- lation-tissue in the joint, and ulceration takes place, or granulation-tissue may form in the epiphyses and perforate the cartilage from beneath. In cases of long standing the disease spreads from the capsule to the surrounding tissues, and the connective tissue, the tendons, and even the muscles, become involved in a gelatinous degeneration. This peculiar change is supposed by some to be a saturation of the diseased tissue with a fluid of a mucous or synovial character. Under favorable conditions a more or less complete restoration of the joint- cavity may take place, but when the disease is once Avell develo|)t'd the best that can be hoped for is a fibrous or bony ankylosis. If suppuration takes place, the abscess may open externally, and fistuhie communicating with the joint may be established. In long-standing cases of joint-suppuration amyloid changes are found in the internal organs. Tuberculosis of the tendon sheaths is usually secondary to bone or joint disease, but it occurs occasionally as a primary affection. A thickening of the tendon sheaths takes place and develops into a cylindrical doughy swelling, Avhich is usually not painful. Rice or melon-seed bodies often form. A por- tion of the new tissue softens down and fistulous openings occur. If the sheath is laid open by a longitudinal incision, a mass of gelatinous tissue is found which can easily be stripped off. Such an operation may result in cure. Tuberculosis of the hpnphatic glands is a very common affection. Enlarged glands may be found at the autopsies of children dying of almost any disease, and on examination prove to be the seat of tubercle. The disease may occur in the glands secondarily to the involvement of some adjacent organ, as in the bronchial or mesenteric glands from pulmonary or intestinal tuberculosis. In the glands of the neck, which are by far most frequently affected, the disease often appears to occur primarily, but is in reality usually secondary to a catarrh of a mucous membrane or to a cutaneous eczema. The bacilli are few in num- ber except in the glands nearest to the primary focus, and in many glands they cannot be found. In abscesses of lymphatic glands they may be found in the TUBERCULOSIS. 81 tuberculous membrane which lines their walls. In the ))r(jnchiiil glands the bacilli are often seen in the capsule and the periglandular tissue. As a result of caseous degeneration and infection with pus cocci abscesses may form, and a spontaneous cure may be rarely eifected. Where an extensive invasion of the lymphatic system takes place the bacilli eventually reach the circulation, and acute miliary tuberculosis may result; but this is brought about more freciuently by the entrance of the bacilli into the veins and their dispersion in emboli to diflferent parts of the body. The diagnosis of tuberculosis can usually be established by the clinical symptoms and history of the case, but in doubtful cases a microscopic examina- tion may reveal the presence of the bacilli. This can be done by an exami- nation of the sputa or urine. (See Surgical Bacteriology.) If the case is one of doubtful lupus, a fragment can be punched out Avith the Mixter exploring canula, and sections can thus be obtained for microscopical study. In those cases in which the bacilli cannot be found recourse must be had to experimental inoculation. A fragment of the suspected tissue can be implanted into the subcutaneous connective tissue of the groin of a guinea-pig, and if the speci- men is tuberculous a miliary tuberculosis will be produced in from five to six weeks. The prognosis of the disease depends greatly upon its locality. In tuber- culosis of the skin and Superficial tissues it is more favorable than that of internal organs. In children the prognosis is generally more favorable than in adults. Any tuberculous nodule is always a source of danger, and should not be allowed to remain if it can be removed. There is always the possibility of recurrence even after operation. The operative treatment consists either in complete removal of the dis- eased tissue by incisions carried through the surrounding healthy tissue or in a thorough curetting, followed by free irrigation with iodine-water or painting with tincture of iodine, packing with iodoform, or occasionally by the actual cautery. In laying open healthy tissues the possibility of an infection of the system with bacilli should not be forgotten ; hence thorough removal or no operation is the rule. Tuberculous cavities, like cold abscess or tuberculosis of the joints, may be treated by the injection of an emulsion of iodoform. A 10 per cent, suspension of iodoform in glycerin may be used for this purpose, or a 10 per cent, suspension of iodoform in Avater with 20 per cent, glvcerin, 5 per cent, gum arabic, and 1 per cent, carbolic acid. The cavity should be first irrigated with a 3 per cent, solution of boric acid. The emulsion is tlien introduced with a trocar about 2 mm. in diameter. The special methods ol dealing with the local conditions Avill be considered in their appropriate places. The general treatment of the disease is of the greatest importance. This consists chiefly in the selection of a suitable nourishing diet and an appropriate climate. When change of residence can- not be effected the patient should be kept as much as possible in the open air. Among the most valuable of internal remedies are cod-liver oil, the hypophosphites, and alcohol. Orriiotherapy (Serumtherapy). The brilliant results which have followed the introduction of orrhotherapy in diphtheria, and the large number of attempts to apply similar principles to other diseases of bacterial origin, make it necessary that all should under- stand, as far as possible, the theories upon which this form of medication is based, what its present status is, and what may be hoped from it in the future. 6 82 .l.V A.Vi:i{r('AX TEXT-BOOK OF SFRf; KHY. Tlie threat difficulty wliich lies in the way of further lulvance i.s the incom- pleteness of our knowledge of the toxins and antitoxins with which we have to deal. A short sketch of the general suhject will give the student some idea of the j)rohlenis involved. The starting-point lies in the fact that certain animals are found to he immune to the attacks of bacteria which are specially virulent to other ani- mals. Thus rats, dogs, and the carnivora generally are not harmed by anthrax bacilli, while mice, cattle, guinea-pigs, and rabbits are vet}' susceptible. Next, it was observed that all fresh blood had some bactericidal pi'operties which it lost if allowed to stand or was heated to .')0° C. (131° F. ). The blood of different animals varied much in its germicidal powers. The potent part was found to lie in the serum, and not in the cellular elements of the blood. Still further study showed that though a given serum or blood might have but little bactericidal |)Ower, yet it might be able to modify the toxin in virtue of which the bacteria exerted their disease-producing power. It was argued that if the bloo c.c. of the serum. Hydrophobia or Rabies. — Orrhotherapy of rabies is quite different from tile method of treatment introduced by Pasteur, lie treated patients who had been bitten by rabid dogs, by injecting emulsions made from the spinal cords of rabbits which had died of rabies, beginning with cords that had been removed for two weeks, and repeating the injection each day or every other day with fresher cords, the theory being that by the time the period of incubation had passed the ))atient would be rendered immune. There has been marked success from this method of treatment, although it has been subjected to much adverse criticism. In the attemj)ts at orrho- therapy, sheep and dogs have been immunized in the above manner, and from their serum a precipitate has been obtained which it is hoped will neu- tralize the poison of rabies and at the same time do away with most of the objectionable features of the Pasteur treatment. Snake-venom. — Calmette maintains that the active toxin of all snake-, lizard-, and scorpion-venom is identical, and that by immunizing a horse with repeated doses of cobra-poison, the strongest of the snake-venoms, he is able to produce a serum of antivenomous properties and capable of neutralizing the poison of the most venomous serpents. The dose of this serum is about 20 c.c, and the serum Avill bear transportation to the tropics and yet retain its antivenomous power. A number of very favorable cases are reported in which lives have been saved by its use (see p. 127). Glanders ; Mallein. — This disease is common to both animals and man. The mallein, which is a glycerin extract of the toxins of the bacillus of glan- ders has a twofold use — diagnostic and immunizing. Injected into a horse having glanders, a characteristic "reaction" takes place. At the end of four to six hours there is a rise of temperature which reaches its maximum of 2^^ C. (3.6° F.) in eight to sixteen hours, rarely longer, and returns to normal in twenty-four to thirty-six hours. This result does not take place in unaffected horses. Immunity follows the injection of gradually-increasing doses, and it is asserted that cures have occurred both in man and in animals in chronic cases treated in a similar manner. Tuberculin. — The treatment of tuberculosis presents many difficulties. In the first place, there seems to be no such thing as immunity. One patient may have a tuberculous process continue for years, and another who has a healed tuberculous lesion appears to be specially susceptible to reinfection. The only conditions in which anything like immunity is obtained are those in which there is a general dispersion of bacilli through the whole organism, as in acute miliary tuberculosis or the form seen in guinea-pigs. If dead bacilli are injected into living tissues, they |)roduce sterile abscesses. The first attempt to secure cure and immunity was by the use of tuberculin, which was a glycerin extract of the toxins of the bacilli of tuberculosis. The iniection of this material gave a distinct characteristic "reaction," or rise of tempei'ature. Tuberculous processes were seen to improve after its use. and as the doses were increased the patient ceased to react even to large doses of the tuberculin. This was a toxin-immunity, and not a bacterial immunity, and only partly a toxin-immunity, as there are other toxins than those extracted BIIA CJIiriS. 85 with ;:;lyct'rin. 'I'lio iiiiprovc'iiK'Ht observed was doubtless due to the stimu- hiting action of th<; toxin upon the tissue-cells. Its use as a diagnostic agent has distinct value. Koch and many others assert tliat there is no danger of setting bacilli free and causing a spread of the disease, as others have maintained to be the case. Some people and some animals react either when the tuberculosis is absent or when it is of but small im]>ortance from a diagnostic point of view, being absolutely latent. Hence, in its use, one has to take this fact into consideration. Koch's new tuberculin, or tuberculin T. R., as it is called, is made with an attempt to overcome the faults of the old glycerin extract. It is impossible, as stated above, to introduce bacilli of tuberculosis and to have them absorbed without abscess-formation. Hence the bacilli are mechanically broken up by grinding in an agate mortar, are put in distilled water, and are centriiugalized. The upper portion of the mass has the properties of the old tuberculin, while the residue at the bottom has different properties, and is called Tuberculin T. R. This contains the constituents of the bacilli insoluble in glycerin, pro- duces no abscess or rise of temperature, and has immunizing power. This immunization takes place in the course of about three weeks in guinea-pigs. The period in man is also short — from four to six weeks. The method of treatment is to begin with a dose of 5^75- of a milligram, doubling the dose each day until a dose of 20 milligrams has been reached. The course of treatment, therefore, covers about four w eeks' time if there are no unpleasant reactions. Lupus and other surface-lesions seem to be most easily affected. Enough time has not yet elapsed to determine finally the exact curative value of the proceeding. Though many favorable cases have been reported, the results are not as satisfactory as could be wished. Serum of horses treated with tuberculin has been tried, but without special success, and now some are advocating the serum of horses that have been treated with tuberculin T. R. In tuberculosis, as in all cases in which orrhotherapy is employed, it is well to begin the treatment in the earliest stage of the disease, in order to secure the best results. CHAPTER XV. EHACHITIS. The term rhachitis is derived from pd-'/e', the spine. The English name rickets is. however, more commonly used. It is a general disturbance of the nutrition of the body in infancy and childhood, and consists principally in an insufficient deposit of lime-salts and in absorption of already-formed bone. Etiology. — It is a disease seen chiefly among the poor in large cities, less frequently in the country. It is much more common and severe in Europe than in America. In America the disease is neither very prevalent nor very severe, and except in colored children or in Italians and Portuguese very great deformity is rare (Bradford). Bad hygienic influences, such as poor venti- lation, damp dwellings, and crowded rooms, are frequent causes of the disease, but the most important cause of all is improper feeding. The substitution of patent foods for the mother's breast-milk is said to favor its development In menag- eries, where animals live under highly artificial conditions, the disease is frequently 86 A.\ AMKRICAX TEXT-llOOK OF SURGERY. observed. In congenital sj'philis changes in the bones closely resembling those of rickets are occasionally seen. The disease begins in the first or second year of life, exceptionally after the fifth or sixth. It is not often seen in newborn infants, but rliachitic changes are occasionally found in the bones during fetal life. The pathological changes are due to the formation of incompletely calcified bone. '* Osteoid tissue " persists, therefore, much longer than usual. At the epiphyses there is an absence of the line of calcification ; there is a great increase in size of the zone of cartilage-growth, and the medullary tissue grows into the cartilage area in the most irregular manner. The cortical portion of the bone becomes porous, and the trabeculne of the spongy bone become thinner or disappear entirely. After the disease has run its course calcification may take place on an increased scale, and sclerosis of the bone may occur. Rhachitic bones are frequently so soft that they can be cut with the knife, and as a result of this change great deformity often occurs. In older children such changes are seen in the bones of the thorax, spine, and extremities ; less frequently in the skull. The ligaments are relaxed and movements of the joints are often painful. The promontory of the sacrum is depressed, and the pelvis thus greatly narrowed. Curvatures of the spine, as scoliosis or lateral deviation, kt/phosis or curvature with convexity back- ward, and lordosis or curvature with convexity forward, are also observed. In the skull the bones are often unnaturally thin and crackle under pressure like parchment. This condition is known as craniotahes. Dentition is often delayed, and during convalescence progresses with great rapidity. It is always irregular. The brain may be hypertrophied, and sometimes is sclerosed ; hydro- cephalus may also occur. The bronchial tubes are filled with mucus, and emphysema of the lungs is occasionally found. Evidences of intestinal catarrh are seen. The spleen is often enlarged. Among the early symptoms is restlessness at night, Avith a tendency to profuse perspiration especially about the head ; the bowels are constipated and the belly becomes distended. The urine is large in amount and loaded with phosphates. In the bones the earliest changes are seen at the epiphyses, which become thickened chiefly at the end of the radius, and in the ribs, where the row of beaded enlargements is quite characteristic. "With the softening of the bones deformities of the spine and extremities begin. The head is increased in size, particularly the forehead and the frontal eminences. The distortion of the ribs gives rise to the characteristic pigeon-breasted deformity. Catarrhal affections, as bronchitis, and even pneumonia, may occur as complications, as also laryngismus stridulus. Among important diagnostic symptoms are delayed dentition and delayed closure of the anterior fontanel. A search for the epiphyseal enlargements will usually settle the diagnosis. Rickety children are often stunted in stature. The prognosis is usually favorable. Deformity disappears in 90 per cent, of the cases. A few cases terminate fatally from complications, such as broncho-pneumonia. In the treatment of rickets careful regulation of the diet is of the utmost importance. Fresh food should be given in preference to prepared foods; fresh milk properly diluted for infants, and meat-juice or raw beef for older children. Fresh air and light in the nursery should be obtained if possible. Salt-water bathing is highly recommended. Cod-liver oil is considered the most valuable of drugs. Phosphorus is also a favorite remedy ; syrup of the iodide of iron is perhaps to be preferred. Lacto-phosphate of lime is given on theoretical grounds chiefly, but is a good tonic for children. Those modem CONTUSIONS AND WOUNDS. 87 inventions, "sea-.shore homes" and "clay nurseries," are particularly adajited for the treatment of this disease. The surgical operations for deformities of bones are described elsewhere. CHAPTER XVI. CONTUSIO^'S AND WOUNDS. SECTION I.— CONTUSIONS. An injury produced by a blunt body in which tissue-elements are more or less rent asunder, but in Avhich there is no gross or manifest external breach of tissue, constitutes a contusion. In a simple contusion or bruise the area of damage is limited by the area of impact of the bruising body, but the amount of damage may be of any grade, from the imperceptible molecular division of a slight bruise to the pulpification of large masses of tissue. The element of contusion is present as a complication of most wounds, and in many constitutes a grave and most important factor. The distinction between a contusion and wound is therefore one of degree and not of kind. A contusion should be defined more properly as a hidden wound, the firmer tissues of the skin being able to resist the rending effect of the blow, which produces its greater effect upon softer tissues underneath. Whether an injury shall be defined as a con- tusion or a wound depends also upon the character of the injured structures and the nature of the tissues which lie underneath the surface. Thus a hard, bony surface, so related to the tissues on which a blow is struck that they are forced against it by the bruising body, will necessarily aggravate an injury, and much more readily cause an absolute destruction of all the tissues, including the skin, and so produce a wound, than if a thick cushion of soft tissue alone is involved. The results of blows over the shin are examples of the first, while those upon the surface of the abdomen or upon the fleshy masses of the nates or the thighs are examples of the second. Pathology. — The pathology of a contusion is that of a subcutaneous wound. The more delicate and easily-torn tissues suffer first and most exten- sively ; ruptured blood-vessels give rise to more or less hemorrhage; injured nerve-fibrils are the sources of pain ; functional disability follows according to the extent and character of the tissues injured; local swelling, both from hemorrhage and from serous effusion, quickly ensues. When the effused blood ahows itself as a somewhat diffused subcutaneous discoloration, an ecchymosis is said to be present ; when, however, it is collected in a more or less well-defined cavity, so as to constitute a blood-tumor, it is known as a hematoma. When blood-vessels of some size are involved in a contusion, special conditions of hemorrhage may ari.se ; thus they may be either ruptured outright or their walls so bruised that they subsequently slough, and so occasion a later hemorrhage. The hemorrhage from the smaller vessels is usually soon controlled after moder- ate escape of blood by the reactive pressure of the surrounding engorged tissues. The force of the blood-current in large veins and in most arteries is likely to be such as to cause a considerable loss of blood, especially when it escapes into any of the great cavities of the body or when the locality involved is one in which there is present much loose connective tissue. Contusions of nerves may produce more or less paralysis of the regions supplied by them. A pro- gressive degeneration of a nerve may result from the changes produced in it 88 A.\ AMI'JilCAX TKX'l-BOOK OF SrUCKHY. by a violent contusion. The effects of contusions of muscles depend upon the extent of the damage done ; local soreness and pain upon movement attend less severe injuries ; rapid recovery under rest and proper treatment is to be expected in such instances ; from even quite extensive lacerations ultimate rectnerv with full functional power often takes place. In less favorable cases, however, atrophy, contracture, and permanent loss of power may result. The contusions of bone Avhen short of absolute fracture are usually rapidly recov- ered from, but may develop into acute or chronic inflammatory conditions or determine caries or necrosis, or even the development of malignant changes. Diagnosis. — The symptoms which indicate the occurrence of a contusion are easily recognized. The part is tender and quickly becomes somewhat swollen, with some elevation of temperature. In simple and superficial con- tusions discoloration of the skin soon declares itself as the result of the subcutaneous hemorrhage. In cases where deeper structures are especially contused the appearance of the external discoloration may be delayed for some days, owing to tlie slowness with which the effused blood finds its way to the surface. Loss of function may be present, dependent upon the character of the tissues injured and the extent of the injury inflicted. The amount of pain in the part may vary. At first there is numbness, followed quickly by severe acute pain, which gradually subsides with the lapse of time. Shock is almost always present to some extent. Contusions of moderate severity pro- duce a degree of shock characterized by momentary stunning ; others of greater severity may produce faintness or total loss of consciousness for a variable period ; while in the more severe cases, as in contusions of the abdomen, immediate death may ensue. Treatment. — For the general shock and the local pain the treatment required for such conditions accompanying any injury is indicated. For the contusion itself the first thing to be secured is rest to the injured part. This is especially important when the contusion is severe and the injuries to deeper structures are extensive. For securing rest, if voluntary immobiliza- tion is not sufficient, the use of apparatus of some kind may be required. Bandages, slings, splints, a recumbent position in bed, all may have their use. By rest local irritation is diminished, hemorrhage and inflammatory effusions are restricted, the absorption of effused fluids and of necrotic tissue is favored, and the normal repair of the injured tissue is fostered. Of all means for treating these injuries, rest is the one of primary and greatest importance. Next, hemorrhage and serous effusion may require attention. Equable, elastic, and firm compression is to be recommended for their control. Com- presses of cotton wool secured by proper bandages are especially serviceable for this purpose. A simple flannel bandage alone will often be of great service. When, for any cause, the use of compresses and bandages is inconvenient or undesirable, some advantage may be obtained from the ap])lication of cold, by ice-bags, evaporating lotions, or affusions of cold water. In the more severe forms of contusion cold is to be used with caution, since by its continued use the vitality of the parts is depressed, and tissues which under more stimulating treatment might be preserved from necrosis and regain their normal condition may be precipitated into absolute death. In the slighter and more superficial forms of contusions evaporating lotions are frequently both convenient and effi- cient. As an example of such a lotion a solution of chloride of annnonium and alcohol (gr. v (o^ f5j) is to be recommended. Tincture of camphor, tincture of arnica, tincture of witch-hazel, all favorite popular Applications for contusions, are of use, but depend for their efficiency chiefly upon the alcohol which they contain. COXTUSIOXS AXl) WOUNDS. 89 In eases in Avhieli much bruising and disorganization of tissues are present great care must be taken to avoid everything which may still further depress the vitality of the part. The indications are, then, to support and stimulate. In addition to the rest already recommended, a moderate amount of heat will be of use ; hot-water bags, the hot-water coil, masses of cotton wool, or flan- nel previously heated, may be found useful. In the later history of many contusions massage and stimulating liniments are of value. Thev promote the activity of circulation in the part, break up and diffuse among the tissues blood-clots and serous accumulations, and hasten their absorption ; they pro- mote the nutrition of the injured tissues, break up adhesions, and expedite the return of the normal functional activity of the contused parts. Blood- extravasations as a rule should be left to the natural processes of absorption for their removal. Blood-effusions Avidely dispersed along connective-tissue planes, infiltrating tissues already lowered in their vitality by a contusion, present conditions eminently favorable for the development of widespread and disastrous septic infection, for which reason an attempt to evacuate a hematoma by incision under ordinary circumstances is always to be deprecated. When, however, continuous subcutaneous hemorrhage is present, showing the existence of a wound of a vessel of importance, it is imperative to make a free incision, so as fully to expose the wounded vessel, and to apply a ligature to it. In such cases the incisions through the external parts should be very free, and all recesses into which the effused blood has found its way should if possible be opened up. All clots should be turned out, and the most perfect disinfec- tion and drainage of the infiltrated areas provided for. Circumscribed blocd- tumors may sometimes be relieved by aspiration. After the lapse of two or three weeks from the time of the original injury any persisting blood-tumcr may be more freely laid open and its contents evacuated ; by this time it will be surrounded by a layer of condensed connective tissue reinforced by inflam- matory exudation ; the surrounding tissues will have recovered from the state of depression immediately following the injury ; and as the result of these con- ditions the danger of septic infection will have greatly diminished. Severe inflammatory reaction following contusion must be treated upon general surgical principles, including rest, elevation of the parts, evaporating lotions, together with such constitutional measures as may be required for relieving pain, reducing temperature, and lessening the intensity of the general febrile reaction. If suppuration occurs, adequate incisions must be made for the evacuation of the pus ; if local gangrene threatens, stimulating applications are first required, as dry heat or stimulating liniments, until the line of demarcation of the slough is distinctly formed. Fomentations should now be used, composed of compresses wet with some antiseptic solution and covered with rubber dam or oil silk, to hasten the separation of the slough. If phlegmonous inflamma- tion advances into adjacent parts, free incision into the inflamed tissues, with abundant antiseptic irrigation and iodoform tampons, should be used. SECTION II. — WOUNDS. A "WOUND is a solution of continuity of any tissue, produced either directly or indirectly by sudden mechanical force. The occurrence of a solution of continu- ity in any of the solid tissues of the body may be due to slowly-acting causes, as the gradual waste of atrophy, or the more active disintegration of ulceration ; but a breach of tissue thus affected would not be a wound. There is involved in the idea of a wound the action of a force outside of the tissue itself, which by mechanical violence has rent or divided its substance. The term " wound," 90 .-l.V AJfKL'fCAX TKXT-JiOOK o/' SI ' l;( ; i:i! V. tlierefore, is susceptible of a very wide range of application. Contusions, sprains, fractures, subcutaneous as well as cutaneous breaches of tissue, are included in the term. In all essential particulars they are identical accidents, involving the same methods of repair and subject to the same principles of treatment, the apparent differences depending upon accidental differences of structure, function, nutrition, relation to other parts, extent of traumatism suf- fered and of exposure to intiuences from without. In the present chapter the ■wounds of bones will not be considered. Classification. — Wounds may be divided primarily into the two great classes of subcutaneous and open wounds. Subcutaneous wounds include all which are unaccompanied by breach of the skin. Protected by the unbroken skin from external irritation and infection, their repair is usually rapid and undisturbed by untoward irritations. The preceding paragraphs devoted to the consideration of contusions are descriptive of the greater number of subcuta- neous wounds. Open wounds, as a class, include all in which there has been a breach of the skin or mucous membrane. Open wounds are subdivided, according to the manner in which they are produced, into incised, punctured, contused, lacerated, gunshot, or poisoned wounds, according as the wounding agent has been a sharp cutting edge, a penetrating point, a dull and bruising body, a tearing force, a projectile impelled by the force of an explosive, or one which carries with it into the wound a poison. Penetrating wounds are those in which the vulnerating body enters a cavity without emerging ; perforating wounds, those in which the vulnerating body both enters and emerges from the cavity. All wounds are accompanied by death of tissue in their track ; even the path of the keenest knife-edge through a tissue is lined by disorganized particles that have been killed by its impact. Between a slight and clean incised wound, in which the destruction of tissue is limited to the molecules traversed by the Fig. 22. Showing the Extensive and Frightful Effects of a Severe Accident (original i. cutting instrument, and an extensive lacerated wound (Fig. 'I'l), with roughly torn and contused edges, or between a slight bruise and a contusion producing the death and disorganization of large masses of tissue, the diff'crence is one of degree and not of kind. The important practical difference which has COATi)SJOA\S AND WOUNDS. 91 always been recognized in the healing of these different classes of wounds depends simply upon the difference between tlie facility with which the devi- talized tissue is j)revented from becoming a source of disturbance to the heal- ing of the wound in the several instances. Wounds may be again classed as aseptic and septic. Asejitic wounds include all which are preserved from contamination by poisonous bacterial products, whether such poison come in contact with the wound directly or be generated in it by the action of germs that gain access to it. An aseptic condition in a wound may be obtained either by the protection which the wound received from the first against the access of any septic agent, or by the power of tissues to resist and destroy septic agents, or by the application to the wound of substances which destroy them. Subcutaneous wounds, as a rule, remain aseptic in consequence of the protecting covering which the skin affords; operative wounds inflicted under certain precautions may be aseptic ; all open wounds in which union by first intention is secured without special and adequate aseptic precautions are examples of the power of living tissues to resist septic infection. Septic wounds include all those in which any agent capable of exciting fermentation or putre- faction lodges and grows. In all cases they are attended Avith some degree of inflammation and suppuration and with sloughing of dead tissue. Symptoms. — The symptoms indicative of a wound are local, dependent upon the efi'ects produced at the point at which the wound is inflicted, and con- stitutionalj dependent upon the effects on the body at large. Local Symptoms. — First, Impairment of Fuxctiox. — A certain amount of disability is the inevitable result of a division of tissue. Its extent and nature will depend upon the amount of injury and the tissue injured. The duration of the disability will depend upon the promptness of healing and the susceptibility of the wounded tissue for perfect repair. Divided tissues tend to retract from each other, and thus a greater or less amount of gaping becomes a wound-symptom. Pain is a usual accompaniment of a wound. It is due to the irritation sustained by the sensory nerves. The amount of pain is of variable quantity. At the moment of the infliction of a wound no pain at all may be experienced, owing to mental preoccupation or excitement or to the rapidity with which the wound was inflicted. The temperament of the individual may modify the amount of pain. Some individuals experience great pain from causes which in others produce but little suffering. The sharp pain usually felt at the moment of the infliction of a wound soon gives way to a dull aching or smarting pain, which may last for some hours, but will finally subside and disappear, provided the Avounded parts are kept at rest and their repair progresses without disturb- ance. Attempts at motion in a wounded part, which tend to pull apart the divided tissues, or the occurrence of a high orrade of inflammation, causing tension and excessive congestion, awakens pain anew. "When large sensory nerve-trunks have been involved in wounds, later and continuous pain may be due to slight inflammatory conditions extending from the wound upward along these nerves ; hence the pain often complained of in the stumps of amputated limbs during the first few days following operation. Hemorrhage. — Some amount of bleeding is the immediate effect of every wound. It is always the invariable and most manifest symptom that a Avound has been inflicted, but the amount of the blood lost may vary greatly according to the constitutional condition of the wounded person, to the character of the tissue wounded, and to the size of the blood-vessels implicated. In scorbutic conditions of the system, and in those occasional instances where a hemor- rhagic diathesis exists, prolonged and even dangerous loss of blood may result 92 .L^' AMERICAN TEXT- HOOK OF SLRGEliY. from a trifling wound. Ordinarily, when merely capillai-ics or small arterioles or venules are divided, spontaneous cessation of licinorrhajije quickl}- occurs, especially if the tissues wounded are retractile, so that the wounded vessels become withdrawn among and embraced by them. AVhatevcr favors the production and retention of a clot about a wounded vessel favors the arrest of hemorrhage; hence lacerated wounds, where the wound-edges are ragged and the openings of the vessels themselves irregular, the coats of the larger vessels, being unevenly divided, are not likely to bleed much, on account of the entan- glement of the blood-fibrin in the irregularities of the wound-surfaces and the speedy production of blood-clot. When large blood-vessels are opened profuse and speedily fatal hemorrliage may occur. Shock. — The primary constitutional symptom of a wound is "shock." Shock is that condition of general vital depression which marks the immediate effect upon the individual as a whole produced by the local wound. It may be of any grade of intensity, from a slight, evanescent, and hardly appreci- able disturbance of mental force to the most profound general depression and speedy death. Its manifestations are through the nervous system, and are exhibited most markedly by depressed action of the circulatory organs — vaso- motor paralysis. Shock is to be distinguished from the effects of hemorrhage ; and in cases of surgical operations from the effects of anesthetics, although in many instances it may be aggravated by either or both. Martin and Hare have recently proposed to use the hemoglobinometer as a means of distinguish- ing hemorrhage, especially intra-abdominal, from shock. In shock the hemo- globin would be unaltered ; in hemorrhage the hemoglobin would be greatly diminished. The pathology of shock cannot be determined by the ordinary methods of research. In such cases death leaves no change which can be detected in any of the tissues. The eff"ects manifest themselves chiefly through the agency of the nervous system in the same way as all the phenomena of life which are controlled by that system. Sometimes, however, as seems to have been shown by Goltz, a marked distention of the intra-abdominal veins exists. The phenomena of shock must be accepted as the measure of the ability of an individual to resist hurtful influences from without. The same injury will produce different degrees of shock in different individuals, and diff"erent degrees likewise in the same individual at different times. Women, as a class, are less susceptible to shock than men. Persons who are inured to suffering, or who by long confinement to bed or by. the influence of drugs have acquired a cer- tain torpidity of the nervous energies, are less susceptible to shock than indi- viduals whose nervous forces are in a high degree of activity. Temperament modifies the manifestations of shock. The phlegmatic and lymphatic tem- peraments resist shock ; the sanguine and mobile temperaments favor it in the highest degree. Mental conditions modify shock ; fear, despair, despond- ency, disappointment, depressed mental states of any kind, aggravate shock ; on the contrary, hope, joy, cheerfulness, glad expectation, success, diminish shock. Age modifies shock. The young bear injuries well, and rally quickly from shock Avhen unaccompanied with much loss of blood ; in the aged the frequent presence of organic disease often renders shock more severe and })rolonged. In the absence of organic derangements the dulled nervous susceptibility of the aged diminishes their liability to shock. Symptoms of Shock. — The symptoms of shock are those of geno-al depres- sion : the skin is pale and cool ; the pulse is feeble and rapid, the respiration is shallow and irregular; the body-temperature is lowered; a sense of faintness is experienced by the individual, and in the more severe forms total loss of consciousness ensues ; the functional activity of all the organs of the body is CONTUSIONS AND WOUNDS. 93 retarded ; musc-ular tone is diminished, with a sense of general muscular pow- erlessness ; the sphincters may fail to act, causing involuntary evacuations ; nausea and vomiting often occur. Every degree of intensity in these symp- toms of depression which have been enumerated may exist in diff'erent cases, from a transient feeling of weakness and momentary mental confusion to abso- lute death. The symptoms of shock are the immediate consequence of the injury sustained. The assumption of the possibility of a condition of delayed shock is not consistent with what has been said as to the nature of shock itself. Whenever a condition of sudden and marked depression declares itself some time after the reception of an injury, it is always due to some dis- tinct cause other than the original injury, and when recovery from shock is delayed and manifests oscillations of improvement and retrogression, distinct diseased conditions, possibly directly resulting from the injury, are always its cause. For this reason the terms which are found in older text-books, and which are still often used in ordinary surgical parlance — namely, delayed shock, secondary shock, and imperfect reaction from shock — may be misleading, as they tend to divert the attention from real conditions. The conditions which most frequently cause these symptoms of later depression are concealed hemorrhage, septic infection, and fat embolism. Pulmonary oedema and renal congestion are also possible conditions always to be inquired after when a sudden unfavorable turn occurs in the condition of a patient soon after an injury has been sustained, especially when ether has been used as an anesthetic. The occurrence of any of these conditions may, of course, produce its own shock, but this shock arises de novo. Prognosis of Shock. — Very quick and complete recovery from a state of most profound shock may occur. The chief elements upon which recovery from shock depend are these: First, whether the injury has to do with a vital part ; and second, whether it entails a continued source of irritation and depres- sion. Thus in injuries to the head the immediate shock may be overwhelm- ing in consequence of the vital relations of the injured part, or Avhen not at once fatal may be continued and masked by inflammatory conditions arising in the cerebral tissues as a consequence of the injury. So in crushing injuries of the extremities: the immediate shock of the injury may be pro- longed and intensified by the pain and irritation arising in the mangled tissues, so that the surgeon is often called upon, even in the presence of much general shock, to run the risks of subjecting his patient to the additional brief shock of an amputation, rather than to leave him exposed to the continued irritation of his mangled limb, with possible added septic infection, while waiting for reac- tion to be established. In general it may be said that Avhen an injury is not primarily fatal through shock, and continually renewed shock can be prevented, speedy recovery therefrom may be confidently looked for under proper treat- ment. Severe shock is so often complicated with the acute anemia caused by loss of blood that it is difficult to separate its prognosis and its treatment from those of the latter condition ; nor in practice is it essential to do so. Reaction. — The symptoms which indicate the passing away of the effects of shock are a gradual increase of the strength and volume of the pulse, a dimi- nution in its frequency, a more natural color and heat of the skin, return of con- sciousness, and the manifestation of muscular power, as the shifting of his position by the patient. The appearance of such favorable symptoms constitutes w^hat is termed a state of reaction. In the most favorable cases reaction is gradual and progressive, though it may occupy many hours or even days in its course. Returning color to the face and an increased power in the heart's action are unmistakable signs of its occurrence. In certain cases fluctations in the reac- 94 A.y A.VKIUCAX TEXT-IIOOK OF SintdKRY. tioH occur, relapse alternating with improvement for a variable time. The real significance of such fluctuations has already been (hvelt upon. In other cases, before perfect reaction ha»s been accomplished, there supervenes a condition characterizeil by a rapid and weak heart's action, cerebral excitement and delirium, muscular tremor, and high body-temperature. These are the signs of septic infection. Reaction from shock is commonly attended by some ele- vation of the body-temperature, quickening of the pulse, thirst, derangement of the secretions, restlessness, and headache. This fever attending reaction may be so trifling and evanescent as to escape notice. Its grade of severity depends chiefly upon the nervous activity of the patient, his previous constitutional condition, and the amount of local irritation produced by the injury, ("liil- dren manifest it most readily. It makes its appearance usually within a few hours after the reception of an injury, and may be expected to decline on or after the second day. This aseptic fever is to be distinguished from the traumatic or surgical fever which sometimes complicates the repair of injuries, which does not develop until two or three days after an injury, and which is dependent upon general blood-infection by absorption of septic matter from the injured part. Propliylaxh of Shock. — In cases of surgical operations it is possible for the surgeon to diminish to some extent the shock resulting from the wounds inflicted. These means include moral, physical, and medicinal measures. The patient should be inspired to believe that success will crown the surgeon's efl"orts. and to place implicit reliance upon his skill. However plainly the surgeon should state the possibilities of mischance to the friends of the patient, nothing but hope and happy expectation should usually be expressed to the patient himself. Among physical means are included all measures of a general character which tend to diminish nervous irritability and promote the general resisting power of the individual. Confinement to the bed for some days is of value as a nervous sedative. The regulation of all the secretions of the body 80 as to secure as nearly a perfect condition of well-being as possible is not to be overlooked. The choice of the period of the day for operating when the vital powers are at their best is likewise to be considered. As a rule, this is during the morning hours. All unnecessary exposure of the body occasioning loss of' body-heat is to be avoided ; if the operation is to be long, artificial heat by hot- water bags and bottles should be applied during the operation. Hemorrhage is to be carefully guarded against and restrained. Medicinal measures include the use of narcotics, as opiates, the bromides, and the free administration of alcohol. These may be of benefit when a state of excessive nervous irritability has to be antagonized. They are of special value in preparing alcoholic subjects for operation. In patients the subjects of malarial cachexia the free preliminary use of quinine should be resorted to. The administration of an anesthetic should be conducted with great care, lest the depressing eff"ect of excessive anesthesia should be added to that of the surgical procedure, but at the same time complete anesthesia should be secured. For the same reason, while avoiding undue haste, operations should be done a? quickly as possible. Strychnia may be used hypodermatically in full medicinal dose, "517 ^^ TmT ^^ ^ grain, after anesthesia has been induced, at the beginning of serious surgical procedures, as a prophylactic against shock through its stim- ulating action upon the cerebro-spinal centers. Treatment of Shock. — Shock, having once become established in a severe degree, requires prompt treatment. If it occurs in the course of a surgical operation, the operation must be brought to a conclusion as speedily as possible, or may even have to be suspended. The head should be lowered and the body CONTUSIONS AND WOUNDS. 95 placed ill tlio reeuiiibciit j)()sitioii, if it is not already so. l{esj)iration should be kept free from impediment, and when practicable thestiinulatiiiiT effect of inhala- tions of oxyijen should be resorted to. Tloat should be applied not only to the extremities, but to tlie whole surface of the body as far as juacticahle. Hot- water bottles and hot blankets should iiave been ])r(»vided for this j)urpose. In cases of severe shock an ellicient and S})eedy method of api)lyiiiK OF SCUdl.HY. is i"(>niic(l between tliein. witli wliicli tlicv hlcml. \\\ the or^raiii/ation aiul development of" the new tissue a |)erniaiient ttoiid of" uiiioTi is foimccl. In no case is union of divided tissue effected without tlie inteijtosition of new material. AVheii divided tissues are at once hrouf^ht into jx'rfect apposition, and there retained and shielded from disturbance, the amount of new tissue required for the accomplishment of union will be extremely small, and may be with difficulty recognizal)le ; but its existence in some degree is nevertheless undeniable. When the process of i-ejiair wliereby the union of divided surfaces is secured proceeds without comj)lication or interruption, union by first intention or by primary adhesion is said to have taken place. (See Cha])ter TIL) This pri- mary union is the ideal to be sought for whenever possible. To secure it it is necessary that the divided surfaces be brought together and kept in close apposition ; that the wound be protected and kept from all further injury ; and that adefjuate local nutritive conditions be maintained. Wliatever interferes ■with any of these conditions will introduce a complication in the healing of a ■wound. It is not infrequently the case that wounds occur in which from the outset it is apparent to a surgeon that in some one or all of these respects it will be impossible to secure the necessary conditions, so that no attempt to secure union by first intention can be made. Thus the loss of tissue may be so great that apposition of the 1 ing cavities, resort must be had to taiii])oning the wound-cavities with materials impregnated with a permanent antiseptic, as iodoform or boric or salicylic acid. In these latter cases, of course, union by granulation is what commonly occui's, but what is practically primary union may sometimes be attained by "secondary sutures." Coaptation. — In the coaptation of wounds the aim of the surgeon must be to bring the severed parts as far as possible into the same relations with each other as existed before the wound was inflicted, and especially to secure the closest possible apposition of eveiy portion of the wound-surfaces. When im})ortant nerves, muscles, and tendons have been divided, especial care must be taken to bring and secure together the divided ends ; all dead spaces where secretions may gather are to be prevented ; and by various means and devices the tissues are to be retained in their restored relation until definite reunion has been accomplished. Under the term " coaptation " all the various aims and methods referred to are included. In the section devoted to Minor Suro-erv the means of accomplishing coaptation ai'e described in detail. Here, however, it will be proper to speak of the general principles which should guide the surgeon in the choice of means and methods. First, much tension must be avoided. When tissues are put unduly upon the stretch in an effort to bring them together, the circulation of the blood within them is impeded, ' nutrition is impaired, the formation of sloughs is invited, and suppurative disturbances are promoted. It is far better to be content with whatever amount of coaptation can be easily secured, and to seek for the healing of any surfaces left uncovered, either by granulation and ulti- mate cicatrization or by skin-grafts. In the second place, care must be taken w^ile securing coaptation to avoid such adjustment of sutures or other retentive apparatus as would be likely to produce strangulation of any portion of the tissue. Sutures too closely applied and too tightly drawn are a frequent cause of necrosis of wound-edges : the pressure of compresses and bandages may likewise be so great as to produce local tissue-necrosis, so that good judg- meiat should always be used in their application. Thirdly, the relaxation of tissues by position should not be overlooked by the surgeon. The spontaneous gaping or falling together of wounds in varying attitudes of a wounded part need but be noticed to suggest the advantage to be derived from placing a part in that position or attitude in which any tendency to gape during the healing process will be reduced to a minimum. The general rule is, therefore, in order to favor coaptation of a wound, to put the part in that position in which the greatest relaxation of the wounded structures can be secured, and in this position they should be fixed and held until firm union has been accomplished. As an accessory to the use of position for securing relaxation is the device of sliding toward the wound tissues somewhat distant from it. By the use of sutures traversing a deeper portion of the wound, and made to embrace portions of tissue on either side at a considerable distance from the wound-edges, and then secured after the manner in which an upholsterer secures the two sides of a mattress together, wounds which gape widely at first may often have their edges so approximated that they are easily brought together without tension. The choice of materials for ensuring continued coaptation is worthy of con- sideration. When a wound is small and there is no tendency to gape, or when that tendency has been overcome by attention to position, the use of a simple compress held in place by a roller bandage may be all that is required to ensure undisturbed healing. In general, however, additional means for secur- ing undisturbed coaptation will be required. For this purpose are used adhe- sive strips and sutures. 102 AX AMi:iil \\()UM)S. lO.'i Hoxiblo, uiiirritating, easy to manipulate, easily sterilized, nearly ahvays attainable, and eheap. A drainage-tube, of Avliatever substance composed, is a foreign body, and as long as it remains in a wound is liable to produce disturbance. It should therefore be removed as soon as the period of profuse secretion which made its original use necessary has passed away, or as soon as the cavity which it was intende WOUNDS. 105 used, it should be chosen ; such splints accurately take the shape of the part, forming a firm mould that encases and fixes the limb ^ithont pressing unduly on anv one ])oint. As a result, such splints are borne "vvith comfort, and thus indirectly contribute still more to the well-doing of the wound. In an emer- gency, however, the ingenuity of the surgeon may be able to bend to his pur- pose, for giving support and fixation to a wounded part, a multitude of difter- ent substances. Constitutional Treatment. — The existence of pain or general restless- ness riMjuirc's the administration of opiates for their relief. The age of the patient, his previous constitutional condition, the coexistence of disease or tendencies to disease, and the hygienic conditions in which he is placed, each must engage the attention of the surgeon in order that whatever special indica- tions they present may be met, and every possible influence that might inter- fere with re])air be guarded against. Even the mental state of the wounded should be regarded. The surgeon who is able to arouse hope, expectation, and faith in the minds of his patients will see their wounds heal more rapidly and certainly than when opposite states of mind exist. As regards the influ- ence of age upon the healing of wounds, although in some cases aged persons display unimpaired ability to repair their wounds, yet as a rule in the aged healincr is much more sluggish and more likelv to suffer from disturbance. In aged patients especial attention must be paid to their nutrition, to maintaining their bodily warmth, and to giving them the stimulating effects of abundant sunlight and pure air. In all cases whatever departures from a perfect standard of health a patient may present should engage the attention of the surgeon. Plethora, anemia, obesity ; that peculiar vulnerability associated with the scrofulous diathesis ; alcoholism ; the exhaustion from overwork, underfeeding, or mental strain ; the depression produced by vicious habits and the habitual inhalation of vitiated air, — these are some of the conditions for the relief of which the surgeon should see that proper constitutional treatment be given. Closely allied to the conditions just named are certain well-marked diseased states, such as s^^philis, tuberculosis, malaria, diabetes mellitus, and scurvy, which by the nutritive defects which they determine delay repair, often arrest it, and subject wounds to the most serious complications. The pre-existence of pyemia, septicemia, erysipelas, phlebitis, or any diffuse inflammation will add special dangers to any traumatism. Diseases of the various organs of the body, and particularly cardiac, pulmonary, hepatic, and renal diseases, modify the effects of wounds, both directly by the constitutional states which they create and w^hich are unfavorable to repair and diminish the resisting powers of the tissues in general, and indirectly by the reaction of the injury upon the pre-existing affection, producing in it temporary exacerbation or per- manent and excessive aggravation, with, not infrequently, speedy death. Each of the conditions named when present will demand constitutional treatment in order to neutralize as far as possible any influence for evil which it might exert upon the healing of the wound. The general hygiene of the patient should be made as favorable as possible. Food insufficient in quantity or bad in quality, extremes of tem- perature, absence of sunlight, depressing climatic conditions, lack of exercise, insufficient and impure air, — these not only create previous constitutional con- ditions unfavorable to repair, but, when continued after the reception of a wound, directly diminish the activity of its reparative processes. The diet of the patient should be regulated so'^that his supply of food should be ample, palatable, and digestible, due regard being paid to personal taste and instincts. lUG .l.V AMi:iiI('AN TEXT-BOOK OF SURGERY. In connection with the sul)joct of aliincut.ition attention should he paid to the action of the bowels and all the excretions and secretions of the body. An abundant supply of sunliglit and of pure air is es[)e('ially iinjwrtant for the well-doing of a person who is confined by a wound to one place, and thus is dependent upon what is brought to him from without for the purification and renewal of the air which he must breathe. This is alike necessary for isolated cases in their own homes and for those in the crowded wards of a hospital. After-Treatment. — The least possible interference with a wound while the healing process is going on is a cardinal principle in surgery. Too early and too frequent interference inevital)ly prevents the steady progress of the healing process. Infrequent dressing is eminently conducive to that absolute I'est which is to be kept in view whatever method of treatment is adopted. When the first dressing of the wound has been conducted in accordance with the principles that have been described, the after-care from the surgeon will be limited to a watchful oversight of the means of protection and immobilization, of drainage, and of apposition that have been employed, so that they may be removed, substituted, or reinforced by others as soon as they are no longer called for or have become inefficient. The prevention of the access of septic organisms, and the removal as fast as formed of materials that may decompose or become the lodging-places of these organisms, constitute two great indications, to fulfil both of Avhich the surgeon must continually strive to the best of his ability if he would acquit himself of reproach for the results of dis- turbance that may supervene in the progress of the wound. Inflammatory, erysipelatous, gangrenous, or septicemic complications attacking wounds are not always to be regarded as unfortunate and unavoidable accidents, but must some- times be accepted as the results of errors or failures in the treatment which the wounds have received. When in the first dressing of a wound it has been possible to close it after perfectly satisfying the indications for treatment that have been detailed, it should not be disturbed until a sufficient time has elapsed for the adhesion of the wounded parts to become firm. From ten to fourteen days may often be permitted to pass before the dressings are removed. The indica- tions which might call for earlier interference, such as the removal of drainage- tubes, have been detailed in a preceding paragraph ; but whenever the external jH'otective dressings remain dry, the wound is free from pain and fetor, and there is no acceleration of the pulse or elevation of the temperature, the dressings may be left undisturbed. Sutures may be allowed to remain as long as their support seems to be desirable, provided they are not causing irritation or sup- puration. In the latter case they should be removed at once. It is impossible to fix arbitrarily the periods for the renewal of the dressings : each case must be a law unto itself. In the changing of the dressings and in all the manipu- lations required about the wound the utmost gentleness should be used. INTERCURRENT COMPLICATIONS. The regular course of the healing of a wound may become disturbed by inflammation, entailing suppuration and possibly gangrene, and if healing is ultimately secured it is accomplished only by a prolonged process of granula- tion. By the absorption into the general circulation of materials formed in wounds thus complicated the general phenomena of septicemia and of pyemia may be produced. "^Inflammation. — With but few exceptions an inflamed wound is a septic wound, and the cause of the inflammation is the irritation of the products of COXTUSIOXS AM) WOrXDS. 107 (lecomposition of retained secretions. It is accordingly those wounds in which the retention of sccrt'tions is most difficult to prevent, as of wounds of joints and other cavities, wounds leading down to fractured }»one, and deep irregular punciured Avounds, in which severe inflamnuition is frecjuently met with. To give free vent, therefore, to all wound-secretions that may have Hbeen retained is the first thing to be attended to in the treatment of such a wound. Tliis may require nothing more than the cutting of a stitch, so that the luitural gaping of the wound nuiy suffice for the reijuired vent, or it may re(|uire counter-incis- ions and tlie use of drains. AVhenever an inflannnation shows a tendency to spread into the adjacent parts, abundant, thorough, and systematic incisions into the affected area must be made, sufficient to provide for the free escape of all irritating secretions. Wherever there is a possibility of a foreign substanee having been left in the wound, such as a splinter of wood, a piece of glass, a rusty nail, a bit of clothing, a detached piece of bone, etc., it should be care- fully souirlit for and removed. If the inflammation has been caused or asirra- vated by mechanical irritation, by motion, or by the premature use of the wounded part, the recognition of such a fact will at once lead to its correction. When the causes of the inflammation have been removed, the parts should be placed in an elevated and comfortable position and subjected to such additional means for relieving the pain, heat, and swelling of the part, and overcoming the vascular congestion on which these depend, as the judgment of the surgeon may determine. In brief, however, it may be said that for the relief of inflamed wounds the surgeon will find of especial value the use of irrigation with cooling antiseptic solutions. Gangrene. — The appearance of gangrene in a wound calls for the imme- diate adoption of even more energetic and thorough antiseptic methods of treatment than have been prescribed in the preceding paragraphs. All loose gangrenous tissue should be removed at once Avith knife and scissors, and the living tissues exposed should be freely and thoroughly cauterized by an 8 per cent, chloride-of-zinc solution, which should be injected into every cavity and recess of the wound. Free incisions and counter-incisions should be made into the swollen and infiltrated tissues leadins; from the firansrenous focus, so as to permit the escape of secretions and debris and to enable the disinfecting liquid to reach every infected part. The Avound should be left uncovered, and contin- uous irrigation Avith an antiseptic solution established. For such irrigating liquid a 1 per cent, solution of carbolic acid or of acetate of aluminium or a 1 : 15,000 sublimate solution may be used. The antiseptic irrigation should be continued until permanent arrest of the gangrenous process is manifest, all necrotic tissues have come away, and a healthy granulating surface has formed. Erysipelas. — The appearance of erysipelas is ahvays due to some defect or neglect in the antiseptic precautions. It is ahvays of specific septic origin, and it most especially calls for that method of treatment adapted to septic Avounds. (For a full consideration of this subject see Erysipelas.) Suppuration. — The occurrence of suppuration in a Avound makes it neces- sary that full provision should at once be made for the easy and perfect escape of the pus. This has already been considered in Avhat has been said in regard to drainage. Some further thought, hoAvever, should be given to the manage- ment of a suppurating Avound, Avith a vicAV to the restriction of the process of suppuration and the hastening of the healing of the Avound as much as possible. When the Avound is shalloAv and Avidely open, and not too extensive, iodoform gauze may be applied upon its Avhole surface as a dressing, and Avill diminish greatly the amount of pus secreted and stimulate the granulating process. The final healing may then be accelerated by the application of a secondary suture 1U8 AN AMEHlCAy TKXT-JiOOK OF SlJiGERY. ■when possible or the employment of skin-grafts. When the supj)uratinif cavity is deep or tortuous, or its external ojx'iiing is conij)aratively small, antiseptic irrigations are of value. Care should be taken in the use of all such irriga- tions not to inject the fluid with so much force as to break up adhesions already formed. Care must also be taken that the possibly poisonous antiseptic be not retained in the wound. This is best accomplished by finally flushing the wound with warm boiled water to wash away the antiseptic solution. Injecting a fr^'sh solution of pero.xide of hydrogen into a suppurating wound answers the same purpose, and is an efficient means of decomposing any retained pus and of sterilizing the Avound-cavity. Solutions of bichloride of mercury, 1 : 2000, of carbolic acid, 2 per cent., or of boro-salicylic acid in saturated solution, are also efficient. "When, notwithstanding the use of these means, the granulating process remains sluggish and the wound-cavities delay in contracting and healing, more strongly stimulating applications are indicated. Naphthalin in powder freely sprinkled over the sluggish surface, or tlie balsams of Peru or of copaiba freely instilled, or tampons of gauze saturated with these agents, may be used. If these are not efficient, superficial cauterizing agents, such as carbolic acid of full strength, fused nitrate of silver, or an 8 per cent, solution of chloride of zinc may be used. In all these cases constant attention should be paid to keeping the deeper parts of the Avound-cavities in apposition by properly-applied pressure, and to securing absolute rest for the injured parts. Especial care must be taken that the external dressings that are applied are such as Avill freely absorb the pus which is brought to the surface. Nothing \eill more aggravate the condition of a suppurating Avound than a dressing that dams back and causes retention of its secretions. Viscid pus is not absorbed to any great degree by the ordinary cotton dressings, and if they are used they must be frequently removed and the Avound cleansed. In ordinary pine saAv- dust of moderate coarseness the surgeon Avill alwaA'S find an easily obtainable substance Avhich absorbs pus freely. It can be made aseptic by baking, and then antiseptic by Avetting Avith a sublimate solution. This saAvdust made into convenient-sized pads by enclosing in any thin gauzy stuff", like cheese-cloth, may be used as a dressing, Avith a certainty that retention Avill not be caused by it, so that infrequent dressing may be the rule even in such Avounds. When by any of the means described a vigorous granulating surface has been obtained and the case is not suitable for secondary suture or skin-grafting, the further treatment of the granulating surface must be one of protection Avhile the gradual process of cicatrization by extension of the cuticle from the edges is going on. Bland or mildly stimulating ointments spread on soft antiseptic dressings of some kind are commonly used for this purpose. Suit- able material for such ointments are the simple cerate of the Pharmacopeia, oxide-of-zinc ointment Avith which a little carbolic acid has been incorporated (f^ss to 5j), boric-acid ointment 15 per cent., iodoform Avith a petroleum basis, such as carbolated cosmoline (sj to .5j), make invaluable a]>plications to such surfaces, and should be employed by preference Avhen the Avound is near a mucous outlet or other possible source of infection. An efficient protection, and one even more cleanl}' and in harmony Avitli ideal asepsis, is to be found in strips of rubber gauze or in the fine oiled-silk material knoAvn as "protective." These should be sterilized by immersion in a carbolic or bichloride lotion of suitable strength for some time before they are used, and Avhen applied upon a granulating surface Avhich has previously been sterilized, and then covered by a suitable antiseptic absorbent dressing, the Avhole forms an ideal dressing for a granulating surface. AVhenever the granulating surface is of any size, resort should be had to skin-grafting for the purpose of hastening its cicatrization COXTCSKjys AM) WOUNDS. 109 whenever practicable. Tliis is a most valuable means for shortening the period of cure in cases of open wounds, and deserves to be frequently used by surgeons. (For the technique of skin-grafting see the chapter on Plastic Surgery.) INCISED WOUNDS. By incised wounds are meant those clean-cut divisions of tissue which are produced by the edges of a sharp instrument. They may vary in size from the most trivial to formidable and deep incisions of many inches in length — from a superficial scratch to wounds opening deep cavities or almost severing entire members from the body. Their surfaces present in a minimum degree an imperceptible layer of devitalized tissue destroyed by the impact of the cutting instrument, tissue, which is quickly removed in the early stages of normal repair and produces no disturbance in the healing of the w^ound. For this reason they present conditions most favorable for speedy healing, and deserve from the surgeon careful attention to all the details of cleansing, apposition, and rest which have been described in previous pages, so that primary union may be obtained. Symptoms. — Pain resulting from an incised wound is severe and sharp at the moment of its infliction, subsiding into a smarting or burning which persists for some time ; . hemorrhage is free, and the gaping of the tissues is restrained only by the limits of the contractility of the tissues divided. Treatment. — In the arrest of hemorrhage, Avhich in general will be accomplished with but little diflSculty, care must be taken to avoid any means or agents which could later prove a source of disturbance in the heal- ing process. The use of all styptic agents should be especially avoided. Bleeding from all but vessels of considerable size will be arrested by temporary pressure, by exposure to the air, or by the application of hot water aided by compression. The mutual pressure of the wound-surfaces against each other after they have been brought into apposition serves to restrain any tendency to further hemorrhage. When large blood-vessels are wounded ligatures are required ; w^ounds involving such vessels are most dangerous, and may quickly terminate fatally from loss of blood, so that the most energetic and instant resort to measures for the arrest of hemorrhage is called for in such cases. When a vessel is but partially divided, it is more difficult to stay the bleeding from it than if it is cut through entirely. In such cases the first thing to be done is to complete the division of the vessel, ligating it later if necessary. The drainage of incised Avounds, when Avith proper care their deeper parts can be maintained in apposition, is very simple. In the more extensive wounds capillary drains or small tubular drains during the first twenty-four or thirty-six hours will suffice. In a large proportion of cases where compression and immobilization of the part can be effected no provision for drainage is required. The apposition of the wounded surfaces should be attended to with the utmost care and minuteness, so that, by the use of sutures, compresses, bandages, and position, coaptation of every part should be perfect and no spaces be left for the collection of secretions. The protective dressings required by incised wounds the coaptation of the surfaces of which is possible are very simple. Exposure of the line of suture to the air, so that the desiccation of the slight amount of secretion that gathers there may form a protective crust, gives excellent results Avhen the conditions of the wound are such as to make it practicable. A light, dry, clean absorbent dressing of some kind is all that is required at any time. The provisions for rest in the case of incised wounds may and should be made absolute by splints. The removal and readjustment of no AN AMFJilCAX TKXT-IK tOK OF SriidKHY. dressing should be long deferred. The ideal to be aimed at is perfect healing without local discomfort or constitutional disturbance under a single dressing. LACERATED AND CONTUSKD WOUNDS. A lacerated wound is one in which the tissues have been forcibly torn asunder ; a contused wound, one in which the wounding force has been of a crushing character. In many instances both the lacerating and crushing elements are mingled. In any case the character and course of both classes of wounds arc similar, so that they may properly be considered together. The surface of such wounds is irregular, shreddy, possibly presenting long flangling strips of fibrous and tendinous tissue, with more or less blood-clot filling the exposed cavities, and with a variable amount of dead or partially disorganized tissue scattered upon its surface. The skin-wound is irregularly torn, less in extent than the wounds of the deeper structures, from which it is more or less separated, while its borders present an area of variable dimensions that is livid and cold, ready to fall into necrosis. The great increase in the use of machin- ery in modern times, and of rapidly-moving and heavy vehicles operated by steam, electric, and horse-power, has vastly multiplied the frequency of lace- rated and contused wounds. Such wounds produce greater shock than do incised wounds, but arc accom- panied by less appreciable pain. The pain is dull and aching in character; the hemorrhage is generallv slight, owing to the surface irregularity that favors the coagulation of the blood fiowing over it, and to the fact that the larger blood-vessels have had their coats so irregularly torn that an occlusive clot is at once formed in the torn ends. The tissue-interspaces for some distance from the wound-opening become infiltrated with diffused and clotted blood, and in many instances foreign material, dirt of every conceivable character, is ground into the Avound-surfiices, so as to defy every effort to remove it entirely. In cases of severe injury of this kind the partial syncope resulting from shock so diminishes the force «f the circulation as also materially to lessen the tendency to hemorrhage. Although for these reasons primary hemorrhage is generally slight, serious later hemorrhage is not infrequent, either within a few hours, when the heart's action has regained its power and local reaction has set in ('Mntermediate " or ''reactionary" or "consecutive" hemorrhage), or at a more distant period, when by the separation of sloughs the vessels are again opened (" secondary " hemorrhage). The external apjjcarance of these wounds often gives no suggestion of the extent of the damage which has been done. They should therefore always be examined with great care, and the possibilities of far-extending subcutaneous injury should be kept in mind. JNIore or less death of tissue is inevitable in the after-course of such wounds. Some tissue, often much, is killed outright by the violence, while yet more is left in a seriously damaged state, prone to fail into necrosis from the defective nutrition that for a time exists in the part. Much of the abundant and irreg- ularlv diffused blood-clot which is present will subsef[uently disintegrate and liquefy. AVhen, with greater or less rapidity according to the activity of the nutritive processes in' the part, all necrotic tissue has separated and been removed, and the blood-clot has either been absorbed or has broken down and escaped, there remains behind a uniform granulating surface, and the further course of the wound is toward healing by granulation. All the conditions presented by these wounds are such as to render them specially liable to septic infection of serious character. Treatment. — Although there may be but little hemorrhage at the time of COyTUSIONS AND WOUNDS. Ill the first dressing of a lacerated or contused wound, yet if vessels of any size have been torn it is the part of -wisdom to a])])ly ligatures to them, though they may not be bleeding at the time. The period of reaction from shock is to be watched with especial care to guard against possil)le hemonhage. Should this hemorrhage at any time occur, the application of a ligature is imper- ative, even though the bleeding may have ceased spontaneously as the lieart's action is Aveakened ; for so soon as the reaction again comes on and the heart beats strongly once moi'e, the hemorrhage will surely recur. The j)rimary cleansing of the wound should be conducted with great care by rubbing sweet oil thoroughly over the surface, including the adjacent skin, then cleansing by soa]) and warm Avater well scrubbed on, following this by washing with alcohol, and finally l)y thorough scrubbing with suldimate solution, 1 : 1000. All detached particles of bone and of the soft parts should be carefully removed, and tissues into Avhich foreign matter has been so ground that the complete removal of the dirt is impossible should be trimmed away with scissors or knife. Bruised portions of tissue that are still attached should be carefully cleansed and replaced and preserved from further traumat- ism, since much that appears to be hopelessly destroyed may be saved in many cases by care in fostering its nutrition. Thorough scrubbing and irrigation of a contused and lacerated wound with a warm antiseptic lotion until no element of sepsis • is left within it is important, for all the conditions of these wounds are such as to create and present to a large degree the material favorable for the rank development of septic organisms. The natural resisting power of the tissues, which enables the surfaces exposed in ordinary incised wounds to resist the development of sepsis and to preserve the minute devital- ized fragments of tissue that are present from undergoing putrefaction, is no longer to be relied on, for the bruised wound-surfaces have to struggle to retain their own vitality, and large masses of devitalized tissue and more copious effusions of putrefiable secretions have to be disposed of. The fullest provision must be made for drainage from all the recesses of the wound. Free counter-incisions must be made wdierever necessary for this pur- pose. Efforts at accomplishing apposition of the wound-surfaces must be sub- ordinated to the need for drainage and the provision for the unhindered separa- tion of necrotic tissue. In cases of severe contusion a degree of uncertainty will always exist as to the ability of the injured tissue to retain its vitality, and a certain amount of necrosis is to be expected and provided for. This necrosis will be reduced to a minimum in proportion as the provisions for making and keep- ing the wound aseptic are thorough and successful. When adequate antiseptic measures are practicable, greater efforts at securing coaptation of the wound- surfaces are proper. Special care should be observed to avoid all tension of the Avounded tissues in the endeavor to approximate them. In a large propor- tion of contused and lacerated wounds there will be such an amount of destruc- tion of tissue that any attempt at closing them to secure primary union will be manifestly contraindicated. In such cases the efforts of the surgeon should be chiefly directed toward protecting the Avound from sources of disturbance dur- ing the time that the separation of the sloughs and the process of granulation are going on. These are the cases in Avhich local septic inflammations, gan- grene, erysipelas, and general septic infection are most prone to occur. The manner in Avhich such disturbances are to be met has been fully discussed in preceding pages. While the constitutional symptoms produced by them Avill often require special treatment, they Avill spontaneously subside if adequate local antiseptic measures are employed. The latter, therefore, should ahvays engage the first and most constant attention of the surgeon. 112 AN AMERICAN TENT- HOOK OF SURGERY. Brush Buhx. — By tliis term is meant a peculiar form of" siiperfieial lace- rated and contused wound caused by friction applied to the surface of the body, as when a portion of skin is brouujht into contact with a rapidly-nioving belt of machinery, or by an involuntary slide down a steep incline, or by the slip- ping of a rope through the closed hand. In this injury the superficial tissiies are ground off and an eschar of considerable depth results. They should be treated by antiseptic fomentations until the eschar has separated and a granu- lating surface has formed, which should then receive the treatment elsewhere described. PUNCTURED WOUNDS. Deeply perforating wounds made by pointed substances will partake of the nature of either incised or contused and lacerated wounds, according to the sharpness of the point of the wounding instrument. Punctured wounds made with sharp, clean-pointed instruments, as pins, needles, trocars, dagger and stiletto points, partake of the nature of limited incised wounds, and unless in their course they have wounded organs of im])ortance, as large blood-ves- sels or nerves, the Avithdrawal of the instrument is followed by rapid and per- fect recovery. Should the puncturing instrument, however, be contaminated with active septic material, an acute septic inflammation will result, depending upon its depth from the surface for its importance, and demanding free incisions for the relief of the pent-up secretions. For its further care those measures which have been described as required for inflamed and infected incised wounds will be indicated. Punctured wounds which are formed by the thrusting into the tissues of irregularly-shaped and blunt substances, such as splinters of wood, nails, a bayonet, and the like, form deep and narrow wound-tracks, the walls of which are contused and lacerated, Avhile minute fragments of devitalized tissues or small fragments of infected material are driven in and deposited in the depths of the wound. The dangers and difficulties attending ordinary contused and lacerated wounds are aggravated in these cases by the long and narrow track which leads from their bottom to the surface. Should no septic material have been introduced by the wounding body, such wounds may yet be expected to heal kindly and promptly if care is taken to avoid their subsequent infection from Avithout and to keep the wounded part at rest while repair is taking place. In view of the impossibility of ade([uately disin- fecting such a wound by mere applications to the surface at the time of the dress- ing, as a general rule it should be freely laid open to the bottom by additional incisions, and there should be thorough disinfection of the wound and the adjacent integument. It should then be covered with an abundant antiseptic dressing, which should be supplemented by any posture or by the application of whatever apparatus that may be required to keep the part at rest. If, notwithstanding this, inflammation of the deeper part of the wound develo))s, immediate resort should be had to suitable free incisions to give vent to pent-up eflusions and for subsequent disinfection and drainage. The more deep and narrow the wound- track, the more important that free and early incisions should be made. Still more important, if possible, are such early incisions when the puncture has involved strong fasciae, the thecfe of tendons, or joint-cavities. Delay in resort- ing to such incisions is not only sure to produce extensive local damage, but may even prove dangerous to life. Not infrequently portions of puncturing bodies are broken off and left imbedded in the tissues. In some cases such imbedded substances may remain innocuous for an indefinite period of time. In yet other instances their presence provokes irritative symptoms of a marked character. Foreign VOXTUSIONS AM> WOUNDS. 113 bodies in the iK'i^liltorhood of joints, or piercing nerves, tendons, or blood- vessels, are sure to be followed by excessive pain, muscular spasm, or hemor- rhage. Diligent effort should be made to detect and remove foiipign bodies at the bottom of punctured wounds whenever there is reason to suppose from the nature of the body or the nature of the tissues wounded that they will become a source of peril or discomfort if allowed to remain, or in any case when the conditions are favorable to making such a search without an unduly extended or dangerous dissection. The instrument inflict- ing the wound should always be inspected to determine whether an}^ of it has been broken off and left in the tissues. For the removal of such bodies the enlargement of the original wound may suffice, or possibly counter-openings at distant points may be re(iuired, so as to give more ready access to the body sought for. Such counter-openings may be of additional value in pro- viding means for thorough drainage. In attempting the removal of minute bodies, such as the fragment of a needle or a small bit of glass, the search may often be facilitated by raising a triangular flap in the centre of the base of which is the original point of puncture, the apex of the flap lying in the direc- tion toward which the body has penetrated. This flap should include the skin and superficial fascia, and Avhen raised gives more easy access to the deeper tissues, and permits a more free and thorough search for any small body which may be imbedded among- them. To make such an operation bloodless, Es- march's bandage is often of the greatest use. The removal of a puncturing body when it projects from the surface, or lies so near the surface that it can be readily seized, is usually easy, but in some cases, by reason of the irreg- ularity of its surface or its being barbed, as a fish-hook or arrow-head, its removal is difficult. Whenever the location of such an entangled body permits it to be easily pushed through to the other side, such a course should be adopted. When this manoeuvre is not feasible, whatever incisions may be required to free the body from entanglement and allow it to be easily plucked out should be made. The hemorrhage in punctured wounds is usually slight and requires no special attention. Should it be at all free, the possibility of the wounding of a large vessel should suggest itself, and a careful review of the anatomical relations of the puncture should be made. Should the hemorrhage not be easily controlled by pressure, the wound should be enlarged, the bleeding point identified, and a ligature applied. A false aneurysm is the not infrequent result of partial divisions of arteries in punctured wounds. Punctured wounds impaling a vein and an artery lying in contact with each other are occasionally the cause of arterio-venous aneurysms. Such sequeli^ call in many cases for free incisions and for exposure of the wounded vessels and ligature above and below the point of Avound. GUNSHOT WOUNDS. The term " gunshot wound " is applied generically to injuries inflicted by missiles, whatever their character, whose force is derived from the explosive power of gunpowder. This definition, therefore, includes every grade of mis- sile, from the smallest bird shot to the immense projectile fired from mammoth pieces of heavy ordnance, and every grade of injury, from the mere peppering of the surface of the skin Avith grains of gunpowder or minute shot to the laceration and comminution of extensive portions of the body. The character of the injury produced when the missile has penetrated the tissues, which is usually the case, is that of a contused, lacerated, punctured wound ; when the surface is merely grazed, it partakes of the nature of the 114 l.V AMERICAN TEXT-HOOK OE SURGERY. brush burn, as already described. In occasional instances a large missile mov- ing with slight momentum fails to break the skin, but produces extensive damage to the subcutaneous tissue. The missiles which are more frequently met with in gunshot wounds are {a) the shot used in fowling-pieces, which are of various sizes, from that of a buck shot, which weighs 133 grains, to that of the smallest bird shot, one of which weighs only ^ of a grain ; {b) pistol bul- lets, varying in size from about ^ of an inch to | of an inch in diameter, and weighing from 20 grains to 240 grains. The size of a pistol bullet is usually designated according to the decimal part of an inch which makes its diameter; thus a 22-caliber bullet is one whose diameter is 22-hundredths of an inch. {<•) The rifle bullet, which is the missile of the modern arm of precision, long and generally conoidal, and weighing from | to 1^ ounces. For military use yet larger missiles have been devised which hardly arrive at the dignity of can- non shot, and yet are heavier than the rifle balls of the infantryman, such as the projectiles thrown by the mitrailleuse, (jatling. and llotchkiss guns. The rifles which are now in general use as military weapons project bullets of small caliber (.25-.32 caliber; 6.5 to 8 millimeters in diameter), which, by the use of cellulose-powder, shells of cupro-nickled steel, and a more abrupt rifling, are driven with greatly increased velocity, and made to revolve upon their longitudinal axis at the rate of over two thousand revolutions during the first second, and to carry to a much greater distance. The destructive effect of the missile is correspondingly greater. It penetrates and de- stroys every tissue with which it comes in contact, pulpefies such organs as the liver and kidneys, and extensively shatters bones. These explosive efti'Cts are not developed at short ranges, but are especially marked at distances of 500 to 2500 Fk;. 2R ber lead bullet (powder, 6 not become encysted like bullets. The experience of military surgeons is uniform that an arrow-head lodged in the soft tissues invariably produces serious results. Hence the rule is without exception that an arrow-head left behind and lodged in the tissues must be removed as soon as j)o.ssible, even \i this removal should recjuire the severest and most dangerous ope- ration (Bill). Injuries t)'otn Electric Currents. — Lii/Iit)iiti(/-!are the cells which are in immediate relation with it for the hyperplasia which soon constitutes the chancre. The chancre ahvays appears at the point of inoculation. If Ave suppose that the syphilitic poison is from the first carried everywhere in the economy, it is difficult to understand why there is not, during one or two months, any other lesion elsewhere than at the point of entrance. The primary lesion is invariably met Avith at the point inoculated, never elscAvhere ; and secondarily, a neighboring gland is SAVollen after the appearance of the chancre, then sev- eral glands ; such glands, as we know from our study of other diseases, arrest for some time the diffusion or generalization of morbid products and tumors. This conception of the localization of the virus at the beginning of the con- tamination is very important in a practical point of view. It Avould indicate that the destruction of the chancre at the moment of its appearance Avould pre- vent syphilis. While there is great difference of opinion among syphilogra- phers upon this point, the weight of authority is against the probability of the abortion of syphilis by excising or otherAvise destroying the chancre. Most authorities are agreed, how'ever, that cauterization or excision of an abraded or absorbing surface soon after exposure, and before the development of the chancre, is strongly indicated, and has probably in several cases prevented constitutional infection. The infecting chancre has a period of incubation varying from ten days to six weeks, the average being about three Aveeks. It is an excellent general rule for prognosis in cases of suspicious ulcers upon the genitals to assume that if an interval of ten days or more has elapsed between the last exposure to contagion and the development of the sore, the latter is probably the initial lesion of syphilis. It begins sometimes by a superficial papule, Avhich generally extends in circumference and depth ; sometimes by an excoriation or a superficial fissure, often very slight. As it spreads upon the skin there are seen accom])anying redness and desquamation of the epidermis : upon the mucous membranes a superficial abrasion or an ulceration covered by a grayish or yelloAvish false membrane ; there is also observed an induration, sometimes giving the sensation of a hard nodule, fibrous or cartilaginous ; at other times, that of a thin plate like parchment or paper. There may be no absolute loss of epidermis over the surface of a chancre, but merely a gradual thinning of the e])idermic layers from the margins of the sore tOAvard its center. Ulceration, Avhen it exists, is a simple cup-shaped depression ; its surface is smooth and the margins are not .SYPHILIS. 143 iibnipt. At the center of the ehanere there is fouii