"RGiSZ^ e<^^ (Enlumhta ilnittfratty \i\ thp (Etty of Nm fork l^tUvtntt Stfarary Digitized by the Internet Archive in 2010 with funding from Open Knowledge Commons http://www.archive.org/details/practiceofobstetOOedga THE PRACTICE OF OBSTETRICS EDGAR THE PRACTICE OF OBSTETRICS DESIGNED FOR THE USE OF STUDENTS AND PRACTITIONERS OF MEDICINE J. CLIFTON EDGAR PROFESSOR OF OESTETKICS AND CLINICAL MIDWIFERY IN THE CORNELL UNIVERSITY MEDICAL COLLEGE; VISITING OBSTETRICIAN TO THE EMERGENCY HOSPITAL OF BELLEVUE HOSPITAL, NEW YORK CITY; SURGEON TO THE MANHATTAN MATERNITY AND DISPENSARY; CONSULTING OBSTETRICIAN TO THE NEW YORK MATERNITY HOSPITAL THIRD EDITION, REVISED TWENTY-THIRD THOUSAND mitb 1279 flUustrations, incluMno tiv>e colored plates ant) 38 figures printed in Colors PHILADELPHIA P. BLAK ISTON'S SON & CO IOI2 WALNUT STREET I9IO Copyright, 1903, by P. Blakiston's Son & Co. Copyright, 1904, by P. Blakiston's Son & Co. Copyright, iqo6, by P. Blakiston's Son & Co. Reprinted, 1910 PP.ESS or F. FELL COMPANY PHILADELPHIA TO THE STUDENTS OF OBSTETRICS OF THE PAST DECADE AND A HALF, WHOM IT HAS BEEN MY PRIVILEGE TO INSTRUCT, THIS BOOK IS DEDICATED BY THE AUTHOR PREFACE TO THE THIRD EDITION. When the first edition of this book appeared three years ago, the author stated in the preface that "the aim of the present Practice of Obstetrics is to . present the subject of midwifery from a practical and clinical standpoint, so that it will best facilitate the requirements of the student of medicine and of the active obstetrician." "To this end the simplest classification has I believe been adopted." This object the author has kept constantly before him in the revisions for the new editions, and how far success has attended his efforts is at- tested to by the demand for ii,ooo copies of the work in less than three years from its publication. The classification adopted in the first edition has been adhered to in the subsequent ones, as from the experience of other teachers and that of the author it has been found generally satisfactory. It has been the author's purpose in the third edition to weigh carefully such criticisms as have appeared, and when possible to meet them. The principal criticism, that the book was too large, has been answered by reducing its size in the present edition by about one hundred pages, although much new matter and 140 new illustrations have been added. This has been accomplished by rewriting, condensing, the omission of some now obsolete matter, and reducing the size of some of the illustrations. Again, it will be noted that the classification is rendered more graphic by the addition of page numbers to the ten part headings throughout the book. It will be noted in comparing the second and third editions that the follow- ing new subjects have been added to the latter, namely: i. Appendicitis Com- plicating Pregnancy. 2. Tapeworm Complicating Pregnancy. 3. Fibroma Mol- luscum Gravidarum (Illustration). 4. Hematoma of the Vulva (Illustration). 5. Lactation Atrophy of the Uterus and Breasts. 6. Brachial Birth Paralysis. 7. Vaginal Incision and Drainage (Illustration). 8. New History Charts for Institution Work. It will be still further noted that the following subjects have been rewritten in whole ..or in part: i. The Development of the Ovum, Embryo, Fetus, Fetal Membranes, and Fetal Structures. 2. Chorio-epithelioma Malignum. 3. The Treatment of Placenta Prsevia. 4. The Toxemia of Pregnancy. 5. The Eti- ology of Eclampsia. 6. Ectopic Gestation. 7. Treatment of Pelvic Deformity. 8. Morbidity in the Puerperium. 9. Indications for the Induction of Abortion and Premature Labor. 10. The Forceps. 11. Caesarean Section. 12. Vaginal Csesarean Section. 13. Porro-Caesarean Section. 14. Complete and Incom- plete Abdominal Hysterectomy. From the foregoing changes it will appear that much time and work have been expended in the present edition in bringing the embryology and pathology of the subject up to date, and that the section on Obstetric Surgery has been largely rewritten and added to. viii PREFACE TO, THE THIRD EDITION. The author still believes it is inadvisable in a text-book designed for stu- dents to burden the text with extensive bibliography and history of the various subjects treated; hence he has introduced this matter only where he has deemed it advisable. The clinical material and experience found in this book were obtained by the author as Attending Obstetric Surgeon during the past eighteen years in The Bellevue Emergency Hospital; The New York Maternity Hospital; The Midwifery Dispensary; The Society of the Lying-in Hospital; The Mothers' and Babies' Hospital; and The Manhattan Maternity and Dispensary. During the above period at least 20,000 cases of confinement have come more or less under the personal observation of the author. With two of the foregoing institutions named, The Bellevue Emergency Hospital and The Man- hattan Maternity and Dispensary, the author is still actively connected as at- tending surgeon. ['$1 For the third time the author desires to express his thanks to the publishers for their continued generosity and courtesy, J. Clifton Edgar. 50 East 34TH Street, New York City. October 15, igo6. PREFACE TO THE SECOND EDITION. The exhaustion of the first edition of this Practice of Obstetrics within four months of the date of its publication, and the many compUmentary reviews which have appeared and personal letters received by the author, have been most gratifying, and I desire to express my appreciation of the fact that my efforts to present the subject of obstetrics from the practical and clinical stand- point have not been entirely unsuccessful. Too short a time has elapsed since the appearance of the first edition to make necessary a complete revision of the work. 1. Under Pathological Pregnancy will be found a section on "The Toxemia of Pregnancy," and under this latter subject I have placed, (i) Nausea and Vomiting, (2) Icterus, (3) Convulsions and Coma, (4) Eclampsia. 2. The section on Fever in the Puerperium in Part VIII of the first edition which included Puerperal Sepsis, has been entirely rewritten and brought up to date under the heading of Morbidity in the Puerperium. 3. All the colored plates of the first edition have been remade, and three new ones have been added to the second edition, namely, two of the Toxemia of Pregnancy, and one of the Stools of Healthy Breast-fed Infants. 4. It will be noticed that many of the illustrations of the first edition have been redrawn, and that forty-five new illustrations have been added to the second edition. Some typographical errors have been corrected and a number of minor changes made throughout the text. 5. I find it necessary in the present edition to restate my position regarding the indications for Embryotomy and Caesarean section, which from the stand point of laboratory and theoretical obstetrics were apparently misunderstood and therefore criticized I find it unnecessary, however, in the second edition to change the relative amount of space devoted to Embryotomy and Cassarean section, namely, eighteen pages to the former and eight to the latter; because Embryotomy comprises eight distinct operations, many of them complicated, and some of them fre- quently performed upon the dead fetus, while Cassarean section, on the other hand, is a single and simple operation, and not so frequently made use of. It is a far cry in obstetrics from the theoretical deductions of the library and the laboratory to the clinical conditions we find at the bedside. The amount of space devoted in the present edition to the Toxemia of Preg- nancy does not imply that the existence of a universal toxic pregnant state is X PREFACE TO^ THE SECOND EDITION. yet established or even fully believed in. The subject is daily assuming in- creasing importance and interest, and it is to be hoped that the physician will study his cases of pregnancy with this possibility in mind, will record and report his observations, and will especially give his patients the benefit of any doubts which may arise when the question of a toxic state is in any way suggested. I desire to express my indebtedness to James Ewing, M.D., Professor of Pathology in the Cornell Medical College, for much valuable help in the prepara- tion of the section upon The Toxemia of Pregnancy. Again I wish to thank the publishers for their continued generosity and courtesy. J. Clifton Edgar. 50 East 34TH Street, New York City. June I, I go 4. PREFACE TO THE FIRST EDITION. This Practice of Obstetrics is founded upon fifteen years' work in maternity hospitals and in bedside and didactic teaching. The cHnical and theoretical material collected from these sources has been rearranged, rewritten, and as far as possible compared with modern authorities. The aim of the present Practice of Obstetrics is to present the subject of midwifery from a practical and clinical standpoint, so that it will best facilitate the requirements of the student of medicine and of the active obstet- rician. To this end the simplest classification has, I believe, been adopted. I have omitted as unnecessary in such a work the elaborate section upon the anatomy of the female genital organs usually found in the works upon obstetrics, and have entered directly upon the physiology of these organs. The omission of the separate section upon anatomy is to avoid repetition, since the anatomy, histological and topographical, of the pelvis and its contents will be found in its appropriate place under the Parts on the Physiology of Pregnancy and Labor. I have divided the work into ten Parts, namely: I. The Physiology of the Female Genital Organs. II. Physiological Pregnancy. III. Pathological Pregnancy. IV, Physiological Labor. V. Pathological Labor. VI. Physio- logical Puerperium. VII. Pathological Puerperium. VIII. The Physiology of the Newly Born. IX. The Pathology of the Newly Born. X. Obstetric Surgery. This classification, elaborated and broadened from year to year, is practi- cally the same that I have followed during the above period in the two depart- ments of teaching. Several innovations will be found in this book. 1. At the beginning of each Part the table of the contents of the part in question has been placed, and to further insure ease of reference each Part is subdivided into sections, each section in turn headed with a sub-table of its subject-matter. 2. The subjects of asepsis and of pelvimetry, including cephalometry, are treated under The Examination of Pregnancy. I believe that this is the proper time and place for the student to be drilled in these subjects. 3. The subject of Deformities and Monstrosities of the Fetus has been entered into more fully than usual under Antenatal Pathology, with 144 illustrations, including all of the common and most of the rarer monstrosities. 4. The illustrations of the mechanism of labor and moulding of the fetal skull in vertex, bregma, brow, face, and pelvic presentation are mostly new, and are arranged as it has been my custom to teach these subjects. The illus- trations of cervical engagement of the presenting part were obtained by palpating with two fingers of the left hand, and at the same time sketching with a soft pencil in the right hand. Inspection of the cervical engagement by the aid of a perineal retractor and reflected light was also used, but this method was less satisfactory than palpation except in the case of face presentation. The illustrations of vulval engagement of the presenting parts are from flash-light xii PREFACE. photographs. Most of this work was done at the Emergency Hospital of Bellevue Hospital. The photographs of fetal skulls showing the result of head moulding are from skulls in the author's collection, which now numbers over one hundred. 5. Short sections upon the medico-legal aspects of obstetrics, together with a brief study of Rape, the latter including an analysis of six hundred con- secutive examinations for evidences of the same, are placed under their appro- priate Part headings. 6. I would especially call attention to the following subjects: (i) The relation of tuberculosis to pregnancy. (2) The teeth in pregnancy. (3) Antenatal path- ology. (4) Monstrosities, and deformities of the fetus. (5) Labor in elderly primiparse. (6) Prophylactic diet in fetal dystocia. (7) Prematurity and asphyxia of the newly born. (8) The diseases of the newly born. (9) Posture in ob- stetrics, and Obstetric Surgery. (10) The complete presentation of the subject of cephalometry. (11) New method for illustrating the mechanism of labor. (12) Pelvic Deformity. (13) Morbidity in the Puerperium. (14) An appendix on obstetric history keeping. Radiography in obstetrical practice is still in its infancy and the results as to fetography have been disappointing. On the other hand, Rontgen pho- tography of the maternal pelvis is a highly promising field, but as yet offers no practical advantages. As far as possible the subject of Embryology has been considered from the practical and clinical standpoint, and detail has been omitted as not suited to a work on practical obstetrics. Anatomical descriptions, except as necessary for the subjects of pregnancy and labor, have also been omitted. Much work had been expended upon the section on antenatal diseases of the fetus, before the appearance of Dr. Ballantyne's pioneer book upon Ante- natal Pathology. This work I have freely consulted in the revision of my manuscript. The 2200 confinement cases from which many of my statistics are drawn comprise 1000 cases from the New York Maternity Hospital and 1200 from the Mothers' and Babies' Hospital; 800 of the latter being dispensary or outdoor cases. The bound histories of these cases have been presented to the New York Academy of Medicine, and are there available for inspection. All unnecessary division into chapters has been discarded, and as far as possible italicizing has also been avoided. To replace the latter a system of paragraphing by means of display type in four series has been uniformly adopted throughout, supplemented by numerical divisions. It will be observed that as far as possible full-page illustrations have been avoided. My aim has been to insert the illustrations in the midst of the text itself so as to more readily catch the eye of the reader. To this end a rather wider page of printed matter than usual has been made use of and the illustrations are of moderate size. Many of the illustrations are new, collected during fifteen years of clinical work, and most of those taken from other sources have been redrawn. The illustrations, as will be noted, are not reproduced to a given scale, as I have found that clearness of detail is best obtained by the use of different scales of reproduction. All weights and measurements are given in English, with the metric system equivalents in parenthesis. To Simon Henry Gage, B.S., Professor of Histology and Embryology in the Cornell University, I am indebted for his critical revision of my manuscript on "The Phenomena Produced by Pregnancy within the Uterus." Also to Drs. Edward Preble and Emma E. Walker for much valuable assistance in the search PREFACE. xiii through recent foreign obstetric literature and in the preparation of the index. The drawings for the illustrations were executed by Frank Stout, Howard J. Shannon, Frederick A. Fulton, and H. C. Lehmann. The author desires to thank most cordially the successive members of the House Staffs of the New York Maternity Hospital, and Emergency Hospitals, for valuable assistance in the preparation of the histories and records of obstetric cases; also Mr. Kenneth M. Blakiston, of the pubhshing firm of Messrs. P. Blakiston's Son & Co., for his unfailing courtesy in the many details of the preparation of the illustrations and the publication of the work. J. Clifton Edgar. 50 East 34TH Street, New York City, yune 15, I go 3. TABLE OF CONTENTS. PART I. PAGE THE PHYSIOLOGY OF THE FEMALE GENITAL ORGANS, i6 This Part Contains 37 Illustrations. SECTION I. Ovulation, 1 7-19 II. Menstruation, 20-26 III. Insemination, 26 IV. Impregnation, . 27-29 V. Rape, 29-34 VI. Hygiene of the Sexual Functions, 35-39 PART IL PHYSIOLOGICAL PREGNANCY, 41 This Part Contains 192 Illustrations. I. Phenomena Produced by Pregnancy within the Uterus 41- 88 II. Phenomena Produced by Pregnancy in the Maternal Organism, 89-118 III. The Diagnosis of Pregnancy 1 19-132 IV. The Differential Diagnosis of Pregnancy, 132-138 V. Feigned Pregnancy — Pseudocyesis, 138-139 VI. Unconscious Pregnancy 139 VII. Multiple Pregnancy 140-144 VIII. The Duration op Pregnancy 144-145 IX. Calculating the Date of Confinement 146-14S X. The Examination of Pregnancy, 14S-184 XL The Hygiene and Management of Pregnancy, 184-188 PART III. PATHOLOGICAL PREGNANCY, 1S9 This Part Contains 276 Illustrations. I. Diseases of the Decidu^, 101-198 II. Diseases of the Chorion, 198-201 III. Anomalies of the Amnion and Liquor Amnii, 201 -208 XV xvi TABLE OF CONTENTS. SECTION PAGE IV. Anomalies and Diseases of the Placenta, 208-237 V. Anomalies of the Umbilical Cord 237-242 VI. Deformities and Monstrosities of the Fetus, 244-254 VII. Antenatal Diseases of the Fetus .255-271 VIII. Death of the Fetus, 272-274 IX. Diseases of the Genital Organs, 274-291 X. Toxemia of Pregnancy, 291-314 XI. Diseases of the Urinary Tract 315-321 XII. Diseases of the Alimentary Tract, 321-325 XIII. Diseases of the Circulatory System, 325-328 XIV. Diseases of the Respiratory System, 329-332 XV. Diseases of the Nervous System 332-33S XVI. Infectious Diseases :i3^-337 XVII. Skin Diseases 337-34° XVIII. Diseases of the Osseous System : 340-342 XIX. The Premature Interruption of Pregnancy 342-361 XX. Ectopic Gestation, 361-367 XXI. Pregnancy in One Horn of a Uterus; Unicornis or Bicornis 367-368 XXII- Missed Labor, 3^8 XXIII. Sudden Death During Pregnancy, 369 XXIV. Injuries and Operations upon Pregnant Women, 369-37° XXV. Pregnancy after Operations Involving the Genitals 370 XXVI. The Fever of Pregnancy, 370 XXVII. The Metrorrhagia of Pregnancy 3 7^-372 PART IV. PHYSIOLOGICAL LABOR, 373 This Part Contains 132 Illustrations. I. The Passages, 375-408 II. The Fetus 408-427 III. Expelling Forces, 428-431 IV. Etiology of Labor, 431 V. The Stages of Labor 432-440 VI. The Mechanism of Labor, 440-448 VII. The Duration of Labor 448 VIII. Live Birth 448 IX. Feigned Delivery, 449 X. Unconscious Delivery, , 449-450 XI. Vertex Presentation, 450-463 XII. Management of Labor 463-496 PART V. * PATHOLOGICAL LABOR, 499 This Part Contains 269 Illustrations. DUE TO ABNORMAL CONDITIONS OF THE FETUS: FETAL DYSTOCIA, 499 Fetal Dystocia from Faulty Attitude, 499 I. Excessive Flexion of the Head, Roederer's Obliquity, 499-500 TABLE OF CONTENTS. xvii SECTION PAGE II. Bregma Presentation. . Incomplete Flexion 500-503 III. Brow Presentation, 503-508 IV. Face Presentation, 508-5 1 8 V. Presentation of Anterior Parietal Bone or Ear. Naegele's Obli- quity 518 VI. Presentation of Posterior Parietal Bone or Ear. Litzmann's Obliquity, 5 ig VII. Prolapse of the Arms. Dorsal Displacement of the Arm 520-522 VIII. Prolapse of the Legs 522 IX. Prolapse of the Cord, 522-527 Fetal Dystocia from Faulty Presentation, 527 X. Pelvic Presentation 527-538 XI. Shoulder Presentation, 538-544 Fetal Dystocia from Faulty Position, 545 XII. Persistent Occipito-posterior Position 545-550 XIII. Persistent Mento-posterior Position 550-553 XIV. Transverse Position of Head at Outlet, 553-554 Fetal Dystocia from General Fetal Conditions, 554 XV. Multiple Birth 554-557 XVI. Multiple or Compound Presentations, 558-559 XVII. Excessively Long Cord 559 XVIII. Short Cord 559-560 XIX. Rupture of the Cord 560 XX. Decapitation of the Fetus 560 XXI. Avulsion of Fetal Extremities 560 XXII. Malformations, Deformities, and Anomalies Producing Dystocia,. . .560-565 XXIII. Fetal Rigor Mortis 565 DUE TO ABNORMAL CONDITIONS OF THE MOTHER. MATERNAL DYS- TOCIA, 566 Maternal Dystocia from the Forces, 567 I. Precipitate ' Labor, 567-568 II. Protracted OR Retarded Labor: Uterine and Abdominal Inertia, .568-574 Maternal Dystocia in the Parturient Tract and Adnexa, 574 III. Retention of Placenta and Membranes 574-577 IV. PosT-PARTUM Hemorrhage 577-584 V. Rupture of the Uterus, 584-590 VI. Inversion of the Uterus, 590-592 VII. Excessive Right Lateral Obliquity of the Uterus 592 VIII. Rupture of Cervix, Vagina, Rectum, Perineum 592-600 IX. Labor After Anterior Fixation or Suspension of the Uterus, 600-602 Maternal Dystocia from Obstructed Labor, 602 X. Uterine, Ovarian, Renal, Peritoneal Tumors, 602-605 XI. Anomalies of the Membranes 605 XII. Rigidity of the External and Internal Os. Trismus Uteri 606-608 XIII. Deviation or Malposition of the Os, 608-609 XIV. Occlusion of the External Os 609 XV. Cancer of the Uterus, 610 XVI. Rigidity and Atresia of the Vagina and Vulva, 610-612 XVII. Vaginal and Vulval Thrombosis and CEdema, 613 XVIII. Distended Bladder and Rectum, Cystocele, Rectocele, Vesical Calculus, 613-615 XIX. Fractures of the Pelvis 615 XX. Diastasis of the Pelvic Joints, 615 XXI. Pelvic Deformity 616-665 xviii TABLE OF CONTENTS. SECTION PAGE Maternal Dystocia from General Maternal Conditions, 665 XXII. Labor in Elderly Primipar^ 665-667 XXIII. Intestinal Hernia 667 XXIV. Cardiac and Pulmonary Disease, 668 XXV. Cerebral and Spinal Disease 668 XXVI. Digestive Disturbances 669 XXVII. Sudden Death, 669 XXVIII. Postmortem Delivery, 669-670 XXIX. The Metrorrhagia of Labor, 671 PART VI. PHYSIOLOGICAL PUERPERIUM. THE PUERPERAL WOMAN, 672 This Part Contains 18 Illustrations. I. General Phenomena, 672-677 II. Local Phenomena, 677-687 III. Diagnosis of the Puerperium, 687-688 IV. Management of the Puerperium, 688-698 PART VII. PATHOLOGICAL PUERPERIUM, 700 This Part Contains 54 Illustrations. I. Puerperal Hemorrhages 701-705 II. Intestinal Anomalies 705 III. Urinary Anomalies, ' 705-707 IV. Anomalies of the Genital Tract, 708-7 10 V. Anomalies of the Pelvic Articulations 710 VI. Diastasis of the Abdominal Muscles 711 VII. Fever in the Puerperium, 71 1-758 VIII. Anomalies of the Breasts, 759-760 IX. Anomalies of the Milk Secretion, 760-761 X. Diseases of the Breasts 761-768 XI. Blood Conditions, 768-769 XII. Diseases of the Nervous System, 769-773 XIII. Skin Diseases, 773 XIV. General Diseases, 773 XV. Sudden Death, 773-776 PART VIII. THE PHYSIOLOGY OF THE NEWLY BORN, 778 This Part Contains 19 Illustrations. I. General Phenomena 779-7S5 II. Hygiene and Management of the Newly Born, 785-796 TABLE OF CONTENTS. xix PART IX. PAGE THE PATHOLOGY OF THE NEWLY BORN, 798 This Part Contains 37 Illustrations. SECTION I. Pathology due to Interrupted Pregnancy. Prematurity, 800-807 II. Affections of Antenatal Origin which Extend into Extrauterine Life, 807-812 III. Affections which Originate Intra partum, 812-837 IV. Diseases Incident to Change of Environment 837-840 V. Diseases due to Bacteria and Fungi, 840-847 VI. Diseases of Unknown Nature, 847-S51 VII. General Post-partum Conditions, •. 852-856 PART X. OBSTETRIC SURGERY, 858 This Part Contains 239 Illustrations. (A) INTRODUCTION, S59 I. Preparations for Operation, 860-86 1 II. Decinormal Saline Solution Injections, 86 1-S65 III. Anesthesia in Obstetrics, S65-S68 IV. Posture in Obstetrics, 868-879 V. Vaginal Examination 879 VI. Digital Exploration of the Uterus, S80 VII. Vulval Douche, S81 VIII. Vaginal Douche, S81-882 IX. Intrauterine Douche 882-S84 X. Vaginal Tampon S84-S85 XI. Uterine Tampon, 885-887 XII. Passing the Catheter 887 (B) OPERATIONS PREPARATORY TO DELIVERY, 887 I. Artificial Rupture of the Membranes, 887-888 II. Induction of Abortion and Premature Labor, 888-895 III. Manual Dilatation of the Cervix, 895-901 IV. Instrumental Dilatation of the Cervix 902-906 V. Manual and Instrumental Dilatation of the Vagina and Vulva, 906-907 VI. Incisions of the Cervix, Vagina, and Vulva 907-91 1 VII. Correction of Faulty Postures, Malpositions, and Malpresenta- TioNS 911-914 VIII. Vectis 915 IX. Fillet, 915-916 X. Reposition of Prolapsed Small Parts, Foot, and Cord, 916-9 19 XI. Version 919-936 XII. Pelviotomy, 936 XIII. Symphyseotomy, 937-942 XIV. Embryotomy in General, ^- 942-944 XV. Perforation 944-946 XVI. Rachidotomy, 946 XVII. Cranioclasm, 947-951 XVIII. Cephalotripsy 951-955 XX TABLE OF CONTENTS. SECTION PAGE XIX. Decapitation 955-960 XX, Evisceration, 960-961 XXI, Amputation of Extremities 961 XXII. Cleidotomy 961-962 XXIII. Spondylotomy 963 (C) OPERATIONS FOR DELIVERY, 963 I. Expression of the Fetus, Expressio Fcetus, 963-964 II. Forcible Delivery, Accouchement Force, 964-965 III. Manual Extraction of the Fore-coming Head, 965 IV. Shoulder Extraction in Head-first Labors, 966-968 V. Breech Extraction, 968-973 VI, Extraction of the After-coming Head 974-982 VII. Forceps 982-1007 VIII. Sling or Soft Fillet 1007-1009 IX. Blunt Hook, 1009-1010 X. Crochet, 10 10 XI. Extraction of the Fetus Mutilated by Embryotomy, loii XII. CjESarean Section 1011-1016 XIII. Abdominal Hysterectomy, 1016-1020 XIV. Porro-C.«;sarean Section 1020-1022 XV, Vaginal Cesarean Section, 1022-1025 XVI. Post-mortem Cesarean Section, 1025 XVII. Delivery of Placenta and Membranes 102 5-103 1 (D) OPERATIONS FOR THE CORRECTION OF INJURIES, 103 1 I. Celiotomy for Rupture of the Uterus, 1032 II. Celiotomy for Sepsis of the Uterus, 1032 III. Repair of Injuries to Cervix, Vagina, Rectum, Perineum, 1032-1037 APPENDIX. This Contains 10 Illustrations. Private History Records 1039-1042 Institutional Records 1043-1046 INDEX ' I047 \ PART ONE. The Physiology of the Female Genital Organs* I. OVULATION. (Page 17.) Definition ; Origin of the Ova ; Causes of Rup- ture of the Graafian Follicle ; Mechanism of the Conveyance of the Ovum to the Tubes and Uterus ; Corpus Luteum ; Retrograde Changes in the Corpus Luteum ; Obliteration of Follicles which do not Rupture. II. MENSTRUATION. (Page 20.) Synonyms; Definition; Puberty; Pheno- mena ; Changes in the Endometrium during Menstruation ; Time of Occur- rence; Conditions Influencing Menstruation; The Menstrual Cycle; Men- struation — Temporary, Intermittent, and Periodic; Duration; Quantity of Blood Lost ; Composition of the Menstrual Blood ; Modifications and Ano- malies ; Relation between Menstruation and Ovulation ; The Menopause. III. INSEMINATION. (Page 27.) Definition; Phenomena. IV. IMPREGNATION. (Page 27.) Synonyms; Definition; The Semen; The Spermatozoa ; Ascent of the Spermatozoa ; Place of Meeting of Spermatozoa and Ovum; Relation between Impregnation and Menstruation; Unconscious Impregnation. V. RAPE. (Page 29.) Definition ; Law of Rape ; Rape on Females after Pub- erty; Conditions Simulating Defloration; Rape upon Children and Infants; Rape by Boys and Children ; Rape on the Dead ; Statistics of 600 Consecu- tive Examinations for Evidences of Rape. VI. HYGIENE OF THE SEXUAL FUNCTIONS. (Page 35.) Heredity; Educa- tion ; Mode of Life ; Dress ; Sexual Life ; Prevention of Conception ; Child- birth ; Climacteric ; Cancer ; Family Physician. I. OVULATION. Definition. — -This term includes the formation, growth, and expulsion of the mature ovum from the ovary. The chief function of the ovary is accomplished in this process. It takes place spontaneously in all viviparous animals. Origin of the Ova. — The ova originate from certain cells which are derived from the ingrowth of the germinal epithelium that surrounds the young ovary, and which are gradually differentiated into the female generative elements. This occurs very early; in fact, the formation of the Graafian follicles is nearly completed during the antenatal period. After birth the formation of new cells is much restricted, and at the end of the second year is supposed to cease entirely. The ovaries of a child of two years are estimated to contain about 70,000 Graafian follicles. The greater number of ova never arrive at maturity. Before puberty some of these immature ova undoubtedly develop to a certain point, but it is not until the establishment of menstruation that the normally complete maturation of the follicles with their ova takes place. With the advent of puberty the sur- face of the ovary becomes covered with small projections. These prominences are the Graafian follicles, which are distended by the liquid within them. They approach the ovarian periphery, cause a thinning of the tunica albuginea, and give rise to the vesicles before mentioned. Gradually the blood-vessels and lymphatics disappear, and at a certain point the covering of the follicles becomes thin and translucent, usually at the place called the macula, or stigma folliculi. When the follicle reaches maturity it bursts, discharging its contents, which consist of an ovum, the liquor folliculi, and a few cells of the discus proligerus. This change takes place periodically, now in one, now in more than one follicle, during the entire child-bearing period. Several follicles in different stages of development may be found at the same time. The particular follicle that is nearing maturity becomes congested and some of the enlarged blood-vessels burst into its cavity, thus increasing the distention and the tendency to rupture. When mature, the follicle is, on account of the escaped blood, of a bright red color. As to the time of rupture of the follicle, whether it occurs before or after menstruation, is a question not yet definitely settled. In order that the ovule may escape, not only must the layers of the follicle be lacerated but also all of the structures covering it. Causes of Rupture of the Graafian Follicle. — Follicular rupture is produced by a combination of several factors: (i) By the pressure of the liquor folliculi, which causes thinning and absorption of the theca folliculi, the follicular wall having been weakened by fatty degeneration of the tissues. (2) B}^ the proliferation of the lutein cells, causing the tension of the liquor to be raised. (3) By the swell- ing of the ovary at every menstrual period. (4) By the contraction of the ovarian muscular fibers. (5) Ovulation is a periodic process, and in nearly all mammals, except man, it occurs only at certain seasons of the year, so that the young are born at a time when food suitable for the parent is most abundant. (6) Sexual congress may influence the discharge of the ovum, probably only hastening the normal process. (7) The sympathetic nervous S3'-stem also in some way affects the process. 2 17 IS PHYSIOLOGY OF THE FEMALE GENITAL ORGANS. Mechanism of the Conveyance of the Ovum to the Tubes and Uterus. — The oldest theory of this conveyance, that held by Rouget, was that the fimbriated extremity of the tube became erectile and, aided by muscular contraction, grasped the ovary. The existence of a peculiar erectility in the Fallopian tubes has, however, been disproved, as experiments show that it possesses none of the characteristics of erectile tissue. Galvanization of the tubes shortly after death produces only a vermicular action which has no effect on the position of the fimbriae. Kehrer's theory was that the ova were ejaculated from the follicle into the tube, a view that has been upheld by few. The most probable theory is that of Henle, that the ova are carried along in the serum by currents generated by the ciliated epithelium which covers the fimbriae of the tubes. This ciliary motion causes a current in Douglas' cul-de-sac. This action has been demon- strated by Pinner, who injected powdered insoluble coloring-matter into the abdominal cavity of a rabbit. Particles were found after death in the uterus and vagina. The same phenomenon was observed by Jani (W^igert's laboratory) in regard to tubercle bacilli. Lodi injected the eggs of a tapeworm into the peri- toneal cavity of rabbits and recovered them in the tubes and uterus. In the lower animals the majority of the ova pass into the tube, but in man it would seem that the greater part are thrown into the abdominal cavity. It is usually stated that it takes eight days for the ova to reach the uterus. In a certain number of cases there is a migration of ova, which pass across the abdominal cavity and come down the opposite tube. This is called external migration. Pathological conditions afford proof of this fact. There are two classes of such cases: (i) With normal tubes. If we find a corpus luteum in the right ovary and the right tube converted into a hydrosalpinx, the inference of external migra- tion may be drawn. Also in tubal pregnancy: given an occluded right tube with a corpus luteum in the right ovary, and a pregnancy in the left tube with no •corpus luteum in the left ovary, and we must draw the same inference. (2) In the case of bicornate uterus a corpus luteum may be found in one ovary and pregnancy in the other side of the uterus. Kussmaul was the first to advocate this view of external migration. Leopold and others have experimented by removing in an animal a tube and the opposite ovary. Later, if the animal became pregnant the proof of external migration was positive. I have re- peatedly demonstrated this external migration of the ovum by operating upon rabbits in the Loomis Laboratory. Older writers declared that there was internal migration causing tubal pregnancy in the opposite tube, the ovum having passed through the uterus. This statement cannot be denied, neither can it be proved. Hence we see that external migration does take place, whereas the occurrence of internal, though possible, has not been proved. Corpus Luteum. — After the follicle has ruptured and the ovum has been cast off, the corpus luteum is formed. As has been said, previous to rupture there has occurred a fatt}^ degeneration of the cells of the membrana granulosa and of the discus proligerus. There is a certain amount of hemorrhage within the follicle, the walls collapse, and this is the first stage of the corpus luteum. The hematin of the extravasated blood gives rise to the "yellow" color. The cells of the internal layer of the theca folliculi rapidly proliferate, forming festoons which project into the blood-clot contained in the cavity of the folHcle (Fig. i). This yellow layer is quite thick, being about one-half the thickness of the whole corpus, which meas- ures half an inch (1.25 cm.). These cells are lutein cells. The stroma of the ovary also sends ingrowths into this mass. The blood-clot organizes, the walls contract, and finally a small, irregular cavity is left. This is at last obliterated by the meeting of the walls, and merely a cleft remains. A corpus luteum is formed OVULATION. 19 with every bursting of a follicle. When fertilization of the ovum occurs, the corpus luteum becomes larger. ■ The old terminology recognizes a corpus luteum verum and a corpus luteum spurium. The corpus luteum of pregnancy meas- ures from about four-fifths to one inch (2 to 2.5 cm.) in diameter, while the ordinary corpus luteum measures about three- fifths inch (1.5 cm.). For some time the idea obtained that there was a marked difference between the corpus luteum verum and the corpus luteum spurium; it has, however, been shown that the only difference is that of size, due to the greater blood-supply during preg- nancy. There has been endless discussion about the corpus luteum, the principal point of dispute being the hyaline change. Retrograde Changes in the Corpus Luteum. — After the formation of the corpus luteum the yellow layer is converted into a hyaline mass which is penetrated by a Tunica externa Tunica interna Stratum granulo- sum (follicular epithelium) Cumulus ovigerus Ovum with zona pellucida, germi- nal vesicle, and germinal spot Fig. I. — Section of a Large Graafian Follicle of a Child Eight Years Old. X 9°- The clear space within the follicle contains the liquor follictdi. — (Stohr.) few bands of ovarian stroma. Finally a thin layer of connective tissue is the only representative of the blood-clot, and this stage is known as the corpus fibrosum or corpus albicans. But still further changes must go on, for only a few of these bodies are to be found in an ovary. The minor details of these changes are not well known. The ovarian stroma prolongations increase, while the hyahne material diminishes and assumes bizarre forms. At last there may be only a trace of connective tissue remaining. Only twenty or thirty folhcles rupture in a year and many ova disappear. Many folhcles never rupture at all. Obliteration of Follicles which do not Rupture. — The ovum may assume signs of maturity, fatty degeneration takes place in the membrana granulosa, the whole mass dissolves in the hquor follicuH, and the fluid finally disappears and the walls collapse. There is absence of blood-clot. The foUicle is surrounded by a thin hyaline stratum formed from the inner layer of the theca foUiculi. 20 PHYSIOLOGY OF THE FEMALE GENITAL ORGANS. II. MENSTRUATION. Synonyms. — Menses; Menstrual flow; Menstrual flux; Flow; Catamenia. Definition. — By menstruation is meant the monthly hemorrhage which takes place in the uterus during the child-bearing period of the normal woman, except during pregnancy and lactation, when it is nearly always suspended. Puberty. — The first occurrence of menstruation with the accompanying changes marks the stage of sexual maturity at which, in the female, fecundation becomes possible. The signs are: The growth of hair on the pubes and on other parts of the body; the enlargement of the breasts; the increased grace of the general contour of the body ; the establishment of ovulation and menstruation ; the full development of the pelvis; the growth of the sexual sense; alteration in. Fig. 2. — Uterus and Adnexa showing Coincident Menstruation and Ovulation. Suicidal death from morphine on second day of menstruation. — (Author's specimen.) the mental qualities, the girl becoming more retiring. The menstrual function is not generally established at once, but for the first few months there may be only premonitory symptoms of a vague and uncomfortable nature. There may soon occur a slight discharge of mucus tinged with blood, and later the regular menses will be established. Phenomena. — (i) The General Phenomena consist of pains in various parts of the body, chilliness, heat flashes, and hysterical symptoms. The reflex nervous system is always at its maximum point of irritability and there is often depression with drowsiness. There are general discomfort, weariness, and a marked distaste for active exercise. Dark circles appear under the eyes, the breasts swell and become painful, and a sense of fulness and oppression is felt in the head (Fig. 6). There are often considerable changes in the general nutritive processes and the excretion of urea by the kidneys is lessened. (2) The Local Phenomena are those of pelvic congestion. Rupture of an ovisac occurs, the MENSTRUATION. 21 - Epithelium Gland tubule Mucosa uterus becomes much congested, the cervix softens and is of a bluish color with relaxation of the external and of the internal os. The uterine mucous membrane is also swollen, congested, and raised into folds which give the surface an irregular appearance (Fig. 2); abundant secretion pours from the glands, and, at least in some cases, the epithelium desquamates, and the capillaries losing their support, their walls undergo fatty degeneration, burst, and discharge the blood (Fig. 4). The tubes are also congested and thickened, and blood sometimes escapes into them. The vagina becomes darker in color, gland secretion is abundant, and the temperature is slightly elevated, often by 1° F. (0.5° C.) (Fig. 7). The whole vulva is swollen and tense and pruritus may occur (herpes menstrualis). Changes in the Endometrium during Menstruation. — Various views have been held as to the changes in the uterus at this time. The prevailing view is that a certain amount of the mu- cosa, though small, is cast off; that there is fatty de- generation of the walls of the blood-vessels which per- mits the outflow of blood, and this is the primary change during menstrua- tion. The flow arises from diapedesis of the blood-cor- puscles. The amount of blood is comparatively small and does not really consti- tute a true hemorrhage. The flow is preceded by altera- tions in the glands, which become hypertrophied and present a zigzag appearance on cross-section, while the cells in the lower part of the glandular structure may become larger and resemble epithelial cells. The con- nective-tissue cells also un- dergo hypertrophy (Figs. 4 and 3). Time of Occurrence. — As has been stated, the establishment of puberty ushers in the process of menstruation. The accompany- ing physical changes give evidence of the capacity for conception and child- bearing now assumed by the woman. In temperate climates the average age for the beginning of menstruation is the fifteenth year. There are, however, many exceptions to this rule within normal limits, as it is not so very uncommon to observe the beginning of this process at the tenth or eleventh year, or its delay to the eighteenth or twentieth. The average age in India is said to be the ninth year, while in Iceland it is given as the sixteenth year. There are recorded curiously abnormal cases of menstruation, pregnancy, and childbirth in early childhood, also of childbirth years after the menopause, which normally occurs about the forty-fifth year. Conditions Influencing Menstruation. — Menstruation is influenced by (i) Fig. 3. — Mucous Membrane of the Resting Uterus OF A Young Woman. X 35. — (Afier Bohm and von Davidojj.) 22 PHYSIOLOGY OF THE FEMALE GENITAL ORGANS. race; (2) mode of life; (3) climate; (4) heredity; and (5) genital sense. Some authors lay considerable stress on the influence of race. It is said that English girls in Calcutta menstruate no earlier than in England, although subjected to the same climatic influences as the Hindoos, i or 2 per cent, of whom menstruate as early as the ninth year, while 25 per cent, menstruate at twelve years of age. The children of the superior classes, being of a higher nervous organization, are apt to menstruate earlier. Their manner of life is more luxurious and mental stimulation is premature, as shown in the earlier period of menstruation. As to the influence Disintegrated surface ":T..pji^~,Jy'.->f'^. Blood-vessels ■ - '.' j?x>^s^V fe^: Excretory duct ._J:?Mv'S^I Superficial epithelium Disintegrated surface Glandular lumen ^■^C'- ;{■■.U/^'^ — ^P'Kit" J — Depression in mucosa '^^y^\-^^,':^lf?^'':J.':l l':M ■S^-^^'^'^-^A%''^-^^^ — Excretory duct •- Gland-tubule Blood-vessel Blood-vessel >-- Muscularis Fig. 4. — Mucous Membrane of a Virgin Uterus during the First Day of Menstrua- tion. X 30. — (Schafer.) of climate, it has no doubt been exaggerated, although the general rule holds that menstruation occurs somewhat earlier in the tropical than in the arctic regions. Premature or late sexual development is often noticed as a family trait. Sexual excitement is thought to influence the advent of menstruation, and Clay * has noted this excitement among the hard-working factory girls of Manchester, where, in the nature of the work, there is a promiscuous mixing of sexes. In the case of pregnancy, menstruation is nearly always suspended during the whole period of gestation, recurring from six to eight weeks after the birth of the * "Brit. Record of Obstet. Med.," vol. i. MENSTRUATION. 23 child. Exceptions to the rule of suspended menstruation in pregnancy occur now and then during the early months, and are explained by the fact that the uterine cavity is not obliterated by the junction of the decidua reflexa and the mucous membrane of the uterus, or the decidua vera, till the close of the fifth month. In case the menses continue throughout pregnancy, — a very rare con- dition indeed, — there is probably an abnormal and incomplete fusion of the deciduag. Naegele * held that menstruation regenerates the capacity for con- ception which had failed by degrees during the intermenstrual period. The relation between menstruation and the "heat" of lower animals is a very interesting study. The most satisfactory theory appears to be that menstru- ation is caused by a central nervous influence reflected through the sympathetic nervous system to the ovaries and uterus. The Menstrual Cycle. — The entire menstrual cycle comprises four stages (Marshall), and extends, as a rule, over twenty-eight days: (i) The preparatory or constructive stage consists in making ready for the reception of the ovum. This preparation, according to Marshall, is probably made for the ovum which is discharged at the preceding period, for it is probable that a week is consumed in the migration of the ovum from the ovary to the uterus. When pregnancy does not occur, this stage is followed by degenerative changes. (2) The destructive stage comprises all the ordinary phenomena of menstruation. It lasts about five days, varying, however, according to individual peculiarities. (3) The re- parative stage is occupied with the regeneration of the destroyed parts of the uterine tissue — the focus of new growth being the unharmed deeper tissues still existing. This process takes place in from three to four days. (4) The quies- cent stage comprises the remaining twelve or fourteen days of the whole cycle and just precedes the beginning of the next period. Menstruation is Temporary, Intermittent, and Periodic. — It is temporary be- cause it exists only during the sexual life of the woman, asserting itself at puberty and declining at the menopause till it ceases altogether. It is intermittent because it comes and goes, and periodic because the series of phenomena repre- senting this physiological process reproduce themselves at intervals of usually one month, being the result of the hyperemia which occurs in the whole genital system of the woman — ovary, tubes, uterus, and broad ligaments. Periodicity is variable, but twenty-eight days is considered the normal period. Two sisters are mentioned in whom menstruation occurred only two or three times a year (Joulin). Duration. — The duration of menstruation averages five days, but varies from three to seven. Some cases are known in which menstruation lasts only a few hours, others in which it lasts many days. Quantity of Blood Lost. — The total amount lost varies normally from five to ten ounces. The amount, even if rather large, need not be considered abnormal unless the general health suffers. High living, rich diet, and, indeed, anything that abnormally stimulates mind and body, will tend to increase the flow. Con- sequently city-lDred girls and those of the higher classes have a greater flow than the hard-worked women of the laboring classes. It is also greater in warm climates than in cold, and English women in India menstruate profusely, while on their return to England there is marked decrease of the flow. The same fact has been noted in American women moving from the Southern States to the Lake region. It appears that women sometimes menstruate more profusely in summer than in winter. The daily loss is not the same during the period. It is shght at first, as a rule, reaches the maximum on the third day, and then gradually de- * "Erfahrungen und Abhandlungen," Mannheim, 1S12. 24 PHYSIOLOGY OF THE FEMALE GENITAL ORGANS. creases. At the last it often ceases for a few hours and then returns. Emotion or excitement of any kind is very apt to bring it on. Composition of the Menstrual Blood. — The discharge is made up of water, red and white blood-corpuscles, mucus-corpuscles, abundant epithelial cells from the uterus and vagina, and rarely strips of uterine mucosa. Virchow believes that some of the epithelium comes from the interior of the uterine glands. The direct discharge from the uterus consists of pure blood, and if it is collected by the speculum it will coagulate. The fact that ordinary menstrual blood does not coagulate has caused much speculation. Mandl has given the true explanation by showing that small quantities of mucus or pus will keep fibrin in solution, and that the former is always found in the secretions from the cervix and vagina and mingles with the blood in its passage from the uterus to the external world. However, in case of excessive flow there will not be sufficient mucus to act on all the fibrin. The color is generally dark at first, while later it becomes paler. Women in poor health often have a very pale discharge. The amount of inter- mingled mucus doubtless has much to do with the differences in color. The reac- tion is alkaline. There is always a faint odor to menstrual blood which is char- acteristic. It has been likened to that of marigolds. It is probabty due either to decomposing mucus or to the mixture of the secretions of the vulvar sebaceous glands. This peculiarity has been noted from the earliest times, and even now in England on many farms the old prejudice of the deleterious effects of menstrual blood is seen in the custom of not allowing menstruating women to attend to the making of butter, preserves, cheese, etc. The influence of menstruation on the general health is very apparent. It is quite common to observe symptoms of marked toxemia occurring a day or two before the flow, such as headache, nausea and vomiting, jaundice, vertigo, and high blood-pressure, which subside upon the establishment of the hemorrhage. Modifications and Anomalies of Menstruation. — At times menstruation occurs through the skin of the mammae. This is probably due to their intimate sympa- thetic connection with the generative organs. Bleeding may also take place from the surface of an ulcer or from hemorrhoids. All of these locations are such as to give easy external escape to the blood. In other cases the bleeding occurs from the nose ; or there may be vomiting of blood or bleeding from the lungs. Cutaneous hemorrhage may take place. Vicarious menstruation is generally a sign of ill health and is usually seen in young women of highly nervous organization. It may begin at puberty and continue throughout the entire sexual life. Its occur- rence is periodic, corresponding with the menstrual nisus, although the amount of blood is generally considerably less than that lost in normal menses. AVe find also such abnormalities as menorrhagia, dysmenorrhea, and retention of menses from obliteration of the neck of the uterus or the vaginal orifice. Other modi- fications are in the suppression of menstruation from pregnancy, from lactation, or from emotion. Relation between Menstruation and Ovulation. — This relation is not entirely clear. Menstruation is not necessary to child-bearing, but there is a marked connection between ovulation and menstruation. Various theories are ad- vanced: by Pfliiger, that the presence of the ripe follicle causes a reflex action which brings on menstruation; by Strassmann, that menstruation is due to pressure changes in the ovary. To prove this he injected a sterile fluid into the ovary and found the animal went in "heat" as a result. It has also been observed that on the second or third day after ovariotomy the patient often undergoes a pseudo-menstruation, probably caused by the pressure of the Hgatures; also that menstruation may continue after ovariotomy. Some have MENSTRUATION. 25 tried to explain this by saying that a portion of the ovary had been left behind or that the discharge was. due to some pathological condition not noticed at the time. These cases, however, are too numerous to be explained on the sup- position of a mistake. Leopold showed that ova mature at all times, both before puberty and after the menopause, and this was observed by others. Lowenthal thought that menstruation depended upon non-fertilization of the ovum; that is, was a primitive abortion. Variations of three weeks have been noticed in the time of delivery corresponding to fertilization just before or just after menstru- ation. Young girls have also become pregnant before menstruation began, and ruptured follicles have sometimes been found in the ovary in the inter- menstrual period. Pregnancy seldom occurs during lactation, though men- struation begins much sooner than the end of lactation. Lawson Tait believed that there are nerves from the tubes to the sympathetic system, and these he called menstruating nerves. All of these facts make the relationship of menstruation to ovulation somewhat obscure. The following conclusions, however, may safely be drawn: Ovulation and menstruation occur about the same time, although ovulation often follows menstruation and may occur be- tween the menses. The ovarian changes which precede ovulation, by producing ovarian tension, refiexly excite the uterus and cause menstruation. These changes are nearly or quite complete before the bursting of the Graafian follicle. The time of labor cannot be accurately estimated, and rules for avoiding concep- tion are very uncertain. Both ovulation and menstruation are under some ner- vous control, yet either process may occur independently. Conception is more apt to result from a coitus just after a menstrual flow than at any other time. Three theories have been advanced as to these relations: (i) Ovulation deter- mines menstruation; (2) menstrual congestion favors ovulation, since there occur simultaneously congestion of the ovary and uterus; (3) menstruation and ovu- lation are interdependent. The Menopause. — The climacteric or change of life varies as widely as does the establishment of menstruation, although the average age is between forty and fifty years. Cases of women menstruating till the eightieth or ninetieth year, which have been reported, must be regarded as exceptional and as having no bearing on the general rule. The great majority of women cease to menstruate in the forty-sixth year; most cases of prolonged menstruation are dependent on pathological conditions — organic disease of some kind, malignant or otherwise. Cases in which menstruation ceased between the ages of thirty and forty years are noted, certain instances being recorded as early as the twenty-fifth year. It is the generally received opinion that women who begin to menstruate early cease to do so at a correspondingly early period, so that the average duration of the function is about the same in all women. But Cazeaux and Raciborski think differently, and they are upheld by the opinion of Guy, which he formed from the observation of 1500 cases. These authors think that the earlier a woman begins to menstruate, the longer she will continue; believing that early menstruation indicates extreme vital energy, and that this continues during the entire child-bearing epoch. Thirty years of sexual activity are considered the normal duration. Climate and other accidental factors do not seem to have so much influence on the cessation of menstruation as on its establishment. The menopause is generally ushered in b}^ gradual changes in the amount of discharge. There are irregularities in its occurrence, and a diminution in amount, or even at times an increase, till finally it ceases altogether. The genitalia all undergo an atrophic change and nervous phenomena appear (Fig. 5). Flashes of heat are very characteristic, and both the physical and mental being may undergo altera- 26 PHYSIOLOGY OF THE FEMALE GENITAL ORGANS. tions. There is a more or less constant tendency to obesity at the time. The notions among the laity as to the great dangers of the menopause are, without doubt, greatly exaggerated. It is not uncommon to see a woman who for years has suffered from uterine and other complaints seem to enjoy robust health after this trying period has been passed. Statistics conclusively prove that mortality at this time is no greater than at any other period. Some have noted that in certain cases, especially of unmarried women, there is a loss of feminine traits LINE OF'SECTION Crural nerve Psoas muscle Iliac muscle ' al artery ( injected) undibiilo-pelvic liga- m.ent >)emng of right tube Obturator artery ngin of uterine and vesicular arteries Broad ligarnent Right ovary Mesenterium tubts fiddle hemorrhoidal artery j?7;g-Ai' ureter Right tube Co7n»wn pudic art. Transverse sec. of round lig- Gluteal miiscle Transverse sec. of rectum Fig. 5. — Atrophy and Prolapse of Rectum Crural nerve Crural artery {injec Med. and small glut, m.uscle Obturator nerve Obturator artery Origin of uterine ar vesicular arteries Ligament, latum cov Left ureter. [left < Left broadjigameni Ischialjierve Middle hemorrhoidi artery ~ Left t,^be Ant. border of pyriform. muscle Transverse sec. of round lig. Common pudic art. Retroverted uterine body Douglas^ pouch Uterus and Adnexa following the Menopause. — and the assumption of certain anatomical male characteristics — a more an- gular form, a harsher voice, or even the development of an imperfect beard or moustache. III. INSEMINATION. Definition. — By insemination is meant the deposition of the seminal fluid within the genital tract of the female during sexual intercourse. Phenomena. — Before conception can take place there must be a meeting and fusion of the vital elements of the two sexes. This is brought about by coitus or copulation, by means of which the semen of the male is deposited in the vagina of the female. This act is called insemination, although fecundation does not follow unless the ovum and spermatozoon come together and amalgamate. When this occurs, the woman conceives and enters upon the period of pregnancy or gesta- tion. The orgasm is the climax of the sexual act. Its normal occurrence is simultaneous in the male and female, and makes conception more probable. When it is not simultaneous, the cervical alkaline mucus protects the spermatozoa Fig. 6. — Breast of a Nulli parous, Married Woman a Few Days Before a Menstrual Period, Showing Changes Identical with Those Produced by Pregnancy. * S» irf to -<• " fjsk Fig. 7. — Vaginal ^^[urous -Memhrane of .v Nulliiwrous \\'oman the First Day of ]\fENSTKUAL PEk lOU. S llOWING CHANGES ANALOGOUS TO I'lUiSE PkoDUCEI) T.V PkEGNANCV. IMPREGNATION. 27 from the acid secretion of the vagina. The collection of semen covering the cervix permits the spermatozoa, by virtue of their inherent power of locomo- tion, to enter the uterus. This explains the occurrence of conception in cases in which the woman has been apathetic during sexual intercourse, having no orgasm, or when she was unconscious from any cause. The time at which insemi- nation is least likely to be followed by fertilization is from the seventeenth to the twenty-third day after menstruation has ceased. It is most apt to occur on the first day after menstruation. IV. IMPREGNATION. Synonyms. — Fertilization; Incarnation; Fecundation. Definition. — By impregnation is meant the union of the ovum and the sperma- tozoon. A woman who has never given birth to a child is called nulliparous, or a nullipara, and her condition is termed nulliparity. The state of capacity for having children is called parity. When a woman is pregnant for the first time she is said to be a primipara, or a primigravida, or a primigravidous woman, or in the condition of primigravidity. In suc- ceeding pregnancies she is a multipara, or a multigravida, a multigravidous woman, or in the state of multiparity. The Semen. — The medium by which the spermatozoa reach the female generative organs is the semen. The semen is a thick, viscid, albuminous fluid, whitish, yel- lowish, or opalescent in color, with a peculiar odor that has been likened to lime or to the filings of bone. It consists of the secretion of the testicles together with that of the prostate and Cowper's glands. It is composed of the liquor seminis, in which are found microscopically the seminal granules and numerous minute anatomical elements termed spermatozoa, which are the vital ele- ments. The liquor seminis, which on chemical exam- ination yields 82 per cent, of water, holds in solution a mucilaginous, odoriferous body called spermatin, as well as protein matter, fats, phosphates, chlorides, and other inorganic materials. The Spermatozoa. — Each spermatozoid (Fig. 8) consists of a flat oval head, which measures about -g-oVo iiich (3-5-0 mm.) in width, and represents the nucleus of an epithelial cell; a small body, and a very long fiHform tail, or flagellum, which in the living spermatozoon is in constant motion. The general appearance of a spermatozoid is that of a tadpole. These little bodies come from the special- ized sperm cells of the epithelium of the seminal tubules in the testicles. The profile of the spermatozoid is pyriform in shape, and its entire length is -g-J-g- to j|-Q- inch (0.05 to 0.06 mm.). The spermatozoa, the most important elements, are not passive constituents of the liquor seminis, simply floating in this medium ; they are endowed with motility, and seem to dart hither and thither as though endowed with volition. It is difficult to realize, in watching the curious move- ments of these minute organisms, as they advance now en masse, now singly, at times diving down, then coming to the surface again, then in their gyrations skilfully avoiding obstacles many times their size, that they are not to a certain Fig. 8. — Human Sper- matozoa. X 360. I. Viewed from the sur- face. 2. Viewed in pro- file. 3. Coiled seminal filament. 4. Sperma- tozoon of bull: a, head; h, middle-piece; c, main-piece. The end- piece and the demar- cation of these parts cannot be perceived with this magnifica- tion. — (Stdhr.) 28 PHYSIOLOGY OF THE FEMALE GENITAL ORGANS. extent possessed of the power of voluntary motion. However, these motions are doubtless due to the undulatory vibrations of the tail, which depend purely upon molecular tissue changes like those which give rise to the movements of ciliated epithelium, or to the ameboid movements of protoplasm. The rate of motion of the spermatozoa has been variously estimated; Henle states that they travel an inch in seven to twelve minutes, or from the hymen to the cervix in three hours (Sims). They have been found within the female genital .organs, with their power of motion unimpaired, eight to ten days after they were deposited there. As soon as the spermatozoa are deprived of this motility their vitalizing power is lost. Environment has much to do with the retention of this power. Extreme heat or cold or excessively acid or alkaline secretions will destroy them. Mercuric chloride has a most untoward effect upon them, as have also the mineral poisons and lack of water. They may be dead when ejaculated, as the result of disease or catarrh of the seminal vesicles or alcoholic or sexual excess; or they may be absent from the seminal fluid in consequence of anatomical defect, or inflammation and obliteration of the seminal ducts. The seminal granule, or accessory corpuscle, is that part of the cell which is extruded in the development of the spermatozoon, and is analogous to the polar globule in the maturation of the ovum. The fifteenth or sixteenth year marks the first appearance of the spermatic particles in the sexual discharge ; although there is frequently a seminal discharge several years earlier, it seldom contains these elements. Very often spermatozoa disappear from the seminal fluid of old men, sixty-five years being the average age, though many exceptions to this rule are on record. The amount of spermatic fluid ejaculated in sexual congress averages about i dram (3.7 c.c.) and the number of spermatozoa, as estimated by Lode, is 226,257,900. If much in excess of this, the condition is termed polyspermism; while if much less, the condition is pathological, and is designated as oligospermism. Ascent of the Spermatozoa, — Many theories have been suggested as to the method by which the spermatozoa reach the uterus. Litzmann, Wernicke, and Beck proposed the aspiration theory, according to which the hood-like layer of the uterus contracts, forcing the cervix down into the lake of spermatic fluid, then, re- laxation following, the semen is aspirated into the canal. Marion Sims' view has been received with the greatest favor. It is that the semen forms a lake in the posterior cul-de-sac, and, the cervix dipping in, the fluid passes up into the uterus. A proof of the truth of this theory is offered by the observation of the great infrequency of pregnancy in cases in which uteri, after operation, cannot dip into the spermatic fluid. It was formerly thought that the current produced by the cilia of the uterus carried the spermatozoa along their upward path, while the tubal cilia wafted the ovum toward the uterus; but Hofmeier, several years ago, showed that the ciliary motion was all in the same direction, toward the outlet of the uterus. Tubal pregnancy shows that the spermatozoa must get into the tube by their own inherent motion. Occasional cases of pregnancy in which conception occurs through a minute opening and an almost imperforate hymen prove the extreme motility inherent in the spermatozoa. Place of Meeting of Spermatozoon and Ovum. — Various authorities have located the point of fecundation in the uterus, tubes, and ovary, and isolated observations are on record showing that fecundation may take place in any one of these organs, as the spermatozoa reach the uterus by reason of their own motility, aided by other mechanism, whence they pass to the tube and wait for the ovum, which may or may not be fertilized. Relation between Impregnation and Menstruation. — It has been practically proved from observations on the wives of sailors and from artificial impregna- IMPREGNATION. 29 tion* that the most favorable time for impregnation is immediately after men- struation ; and also that the spermatozoa may retain their vitality in the vagina for at least seventeen days, even through a menstrual period. Instances are known in which insemination, occurring just before a menstrual period, was followed by pregnancy and delivery at term.f Menstruation under such circumstances may be perfectly normal, and the downward current of blood does not interfere with the upward passage of the spermatozoa to the Fallopian tubes. Hist examined sixteen embryos with the utmost care. He found that in twelve the stage of development proved that impregnation had occurred, not at the time of the last, but at what would have been the next, menstrual (first missed) epoch, had not the woman become pregnant. The remaining four embryos in their develop- ment corresponded to impregnation occurring at the last menstrual period. Duncan says, in this connection, that when a fertilizing insemination takes place just before the period is due, the latter frequently "does not take place at all, or only very scantily; the uterine system, as it were, anticipating the conception and preventing the failure which might result from a free discharge of blood." It is quite evident that such cases, occurring in married women, would be very liable to be considered "cases of gestation protracted a. month." Unconscious Impregnation. — A woman may become pregnant in a state of partial or complete unconsciousness. In cases of rape young girls have been impregnated while unconscious as the result of fright, a blow, drugs, or alcohol. Impregnation during unconsciousness as the result of anesthetics, chloroform, ether, or nitrous oxide is also possible. Artificial impregnation, the seminal fluid having, with suitable instruments, been injected directly into the uterus, has also been successfully performed. Brouardel,^ who has studied and written upon this subject, states that copulation and impregnation can occur in a woman without her knowledge during hypnotic sleep. "That a woman should be un- conscious both of the fact of sexual intercourse, and also continue unconscious of the resulting pregnancy up to the birth of the child, we decline to believe, unless she was feeble-minded or idiotic." (Reese.) V. RAPE.II Definition. — Rape, derived from raptus mulierum, signifies carnal knowledge of a female by a man, forcibly and unlawfully, without her consent. It may, however, be committed by fraud or by intimidation. Law of Rape. — Common law declares a female under thirteen years of age incapable of giving consent. Carnal knowledge between thirteen and sixteen is regarded as a misdemeanor ; it is not a crime if the age is over sixteen and there is consent. The testimony of the prosecutrix alone is considered legally com- petent, since she and the offender are generally without other witnesses. As false accusations of rape are common, the corroborative testimony of medical evidence is generally required. In 600 accusations I could find evidences of penetration in but 386 instances. In 212 there was no evidence what- * Bossi: " Nouvelles Archives d'0bst6trique et de Gyn^cologie," Paris, April, 1S91. t Milne Murray: "Edinburgh Med. Jour.," Sept., 1S92. t "Anatomie menschl. Embryonen," Abth. I. V., II., Leipzig, 1SS2. § " Gaz. des Hopitaux," 1S77. II See more exhaustive article, "Medico-legal Consideration of Rape," by Edgar and Johnston, "Medical Jurisprudence, Forensic Medicine and Toxicology.'," Witthaiis and Becker, vol. 11. 30 PHYSIOLOGY OF THE FEMALE GENITAL ORGANS. ever of penetration of the genital organs and in two cases menstruation and chancroids rendered the diagnosis uncertain. The examination should be made as soon as possible after the assault, and the physician should carefully note the time of his examination and try to obtain by inquiry the exact time of assault. The female should be allowed no time to prepare for the examination. Several points should be kept in mind and noted by the physician: (i) Signs of violence on the genitals of the female; (2) signs of violence on her body or that of the defendant; (3) evidence of blood or semen on the body or clothes of either; (4) the existence of venereal disease, syphilis, chancroid, or gonorrhea, in one or both of the individuals concerned. The evidence of masturbation and criminal assault may be present in the same instance, and in the majority of cases the medical expert can swear only to the "penetration of some blunt instrument." The subject may be treated in four parts: (i) Rape on females after puberty; (2) rape on children and infants; (3) rape by boys and women; (4) rape on the dead (necrophilia). False accusations are considered throughout the text. I. Rape on Females after Puberty. — The fourchette and posterior commissure are often destroyed by the first delivery, but they are seldom injured by sexual intercourse. In 386 penetrations the fourchette was lacerated in but 17 of the cases observed by me. The hymen is the most convincing sign of virginity. It is a membranous structure guarding the entrance to the vagina and making a line of demarcation between it and the external genitals. There are four chief forms, with many variations. These are: (i) A form with a central, antero-posterior opening; (2) the semilunar; (3) the annular; and (4) the diaphragmatic. (Figs. 9 to 33.) * The first and third are the most common varieties. The imper- forate hymen is a pathological condition. Is the presence of an intact hymen evidence of virginity? Although the presence of the hymen is not absolutely invariable, still it is unquestionably the most valuable physical sign. However, even when it rem.ains uninjured, it does not offer positive proof that rape has not been committed. This is especially true in the case of young children, in whom it is deeply placed, and the organs are undeveloped; for it must be remembered that the slightest penetration is a crime. Authentic cases in which prostitutes have had perfectly preserved hymens are on record. f It may even persist after delivery, remaining as a loose ring. J Does the absence of the integrity of the hymen, on the contrary, indicate defloration? The greatest care must be exer- cised in deciding this question. The hymen may be injured manually, as in one of my cases by a midwife; or it may be destroyed by accident, as by falling astride of an object; again, violent exercise may rupture it — e. g., horseback- riding. Congenital absence of the hymen is known (Fig. 35). Surgical opera- tions or vaginal examinations, roughly conducted, not infrequently cause rup- ture. The breasts are only slightly affected by handling and sexual indulgence. One sign alone cannot afford positive proof of virginity, but all taken together give assurance of it. It is well known that the use of vaginal astringents may tone up and narrow the vagina and even restore the hymen to a great degree. In complete recent defloration the hymen will furnish the most convincing proof, but the external genitals may also be inflamed to a greater or less extent ; and if the inflammation is extreme the patient's movements will be interfered with and she will evince a great dread of opening the thighs. These signs are most im- portant and are seldom simulated. There may also be signs of violence on the *Figs. 9 to 33 inclusive, and Fig. 35, are from E. Von Hofmann's "Atlas of iLegal Medicine." t Grey's " Forensic Medicine," p. 49. J Stolz: "Annales d'Hygi^ne," 1873, t. 2, p 148. RAPE. 31 Fig. 9. — Circular Hymen WITH Wide Opening and Circular Smooth-edged Margin of Equable Height Throughout, Fig. 10. — Semilunar Hymen. Fig. II. — Semilunar Hymen. ,. if^^' Fig. 12. — Hymen of Newly Fig. 13. — Circular Hymen Fig. 14. — Deep Irregular Born Child with Deep with Deep Congenital Notch of the Hymen of Notches to the Right Notches. Edges Smooth a Newly Born Infant. AND Left. and Rounded. Fig. 15. — Congenital Deep Irregular Notch of Hy- men. Fig. 16. — Fimbriated Hy- men in a Virgin. Fig. 17. — Serrated or Fim- briated Hymen in a Vir- gin. 32 PHYSIOLOGY OF THE FEMALE GENITAL ORGANS. Fig. i8. — Hymen Bipartus OR Septus or Divided Hy- men. Fig. 19. — Hymen Bipartus orSeptus or Divided Hy- men. Fig. 20. — Hymen Septus in AN Unmarried Woman Twenty-four Years Old. Strong and Thick Sep- tum. P^^. T^l'Cf Fig. 21. — Large and Small Openings in a Divided Circular Hymen. Fig. 22.— Circular Hymen Fig. 23. — Circular Hymen OF AN Adult Parous of Virgin, Age Twenty Woman. Years. Hymen Partim Septus. Fig. 24. — Circular Hymen with Congenital Trans- verse Septum in Girl of Seventeen Fig. 25. — Divided Hymen Fig. 26. — Circular Hymen of Infant with Thick of Child, Age Twelve, Transverse Septum. Ruptured by Rape. Death in Ten Days from Peritonitis. RAPE. 33 Fig. 27.— Circular Hymen WITH Old Healed Lac- eration TO Left and Right. Fig. 28. — Remains of Hy- Fig. 29. — Hymen after Sev- MEN Six Months after eral Labors. Shape Or- Delivery at Term. Car- iginally Circular. UNCULiE MyRTIFORMES. Fig. 30. — Divided Hymen OF A Prostitute Eigh- teen Years Old. Coitus Took Place through the Left Opening. Fig. 31. — Remains of a Di- vided Hymen after De- floration AND Parturi- tion. Fig. 32. — Hymen from a Woman, Age Twenty- nine, Who Died in Sixth Month of First Preg- nancy. Originally a Di- vided Circular Hymen. .^^i^.y-*- FiG. 33. — Hymen from El- derly Multiparous Woman. Fig. 34. — Parental Rape ON Infant Eight Months Old. Complete Lacera- tion OF Pelvic Floor. — (New York Children's So- ciety.) -# r~ --•>* Fig. 35. — Congenital Ab- sence OF Hymen. Mas- culine PSEUDOHERMAPH- rodism. Female Infant WITH Normal Internal AND Hermaphroditic Ex- ternal Organs. 34 PHYSIOLOGY OF THE FEMALE GENITAL ORGANS. genitals, thighs, abdomen, or perineum. The hymeneal tear itself may be attended with pain and difficulty in walking. Attention should be paid to the manner in which the hymen is torn, as well as to the appearance of the edges of the segments. As a rule, healing takes place in from eight to twelve, or at most twenty, days. Rarely the tears of the hymen unite; if they do, a cicatrix may remain. Incomplete recent defloration is usually seen in young children. Non- recent defloration may be told chiefly from the absence of a complete hymen, its remnants only remaining. The vulval canal is likely to be dilated. Conditions Simulating Defloration. — Traumatism, all ulcerative and gangren- ous affections of the pudendum, chancre, chancroid, mucous patches, and herpes progenitalis may each cause such destruction that the results may simulate those caused by intromission. An extreme degree of leucorrhea or an excessive menstrual discharge may cause dilatation of the vagina and superficial ulceration of the mucous membrane, like that produced by coitus. Again, marks of vio- lence must be considered. Stains of blood and semen should be carefully exam- ined. Vaginal discharges must be scientifically considered. Leucorrhea must be differentiated from gonorrhea. Can a woman be violated against her will? The best authorities believe fully that a mature woman, in full possession of her faculties, cannot be raped by a single man against her will. In the case of a child or an old woman, or when there are two or more assailants, the conditions are very different. Terror may in certain instances cause paralysis. Can rape be accomplished during natural sleep? This is probably unlikely, indeed impossible, in the case of a virgin. Rape by fraud, unfortunately, is widely prevalent, as in the impersonation of a husband. Rape on psychopathic individuals, in the hypnotic state, and during unconsciousness from narcotism, alcoholism, and anesthesia has occurred. 2. Rape upon Children and Infants. — This is far more common than the crime on adults, for it is easier to perpetrate, and there is a wide-spread super- stition among some nationalities that intercourse with a virgin is a sure cure for venereal disease. On account of the disproportion between the organs, the crime usually consists in placing the head of the penis between the labia majora or the thighs of the child. There are great differences between the genital organs of the child and the adult. The whole vulval canal is relatively much longer in youth than after puberty. It is important to examine the fourchette and com- missure for evidence of rape in children, since, on account of the very small open- ing, injury is more common in their case than in that of mature women. The hymen is very deeply situated in the child and there is almost no possibility of intromission. The pubic arch, as well as the vagina and its entrance, are very narrow. One of my 600 cases was rape by a father upon his daughter eight months old, causing complete laceration of the perineum from vagina to rectum. The hemorrhage was controlled and the perineum repaired with sutures (Case No. 70,542) (Fig. 34). G. P.; bom in United States; aged eight months; seen February 17, 1893, soon after assault. The external genital organs were found to be greatly swollen, contused, and oedema- tous. Complete laceration was foiuid to have occurred at the vaginal and rectal orifices, ■causing loss of tissue between these two orifices and for some distance up on the recto-vaginal ■septum, so that the vaginal and anal orifices appeared as one, surrounded by a bleeding ■mass of lacerations. The child was removed to a hospital and an operation requiring the introduction of several sutures was necessary to control the bleeding and partially to repair the torn parts and restore them to their original condition. Defendant in this case was ■charged with attempt at rape, pleaded not guilty, was adjudged insane, and committed to tiie State Asylum for Insane Criminals at Matteawan. 3. Rape by Boys and Women. — Erections are known to be possible at four HYGIENE OF THE SEXUAL FUNCTIONS. 35 years of age, although both in this country and in England a boy under seven years cannot legally commit a' felony. Rape by women, or rape by females on males, is not uncommon. It is generally committed by an adult woman to gratify a perverted sexual instinct, or while in a state of nymphomania. There is a super- stition among the ignorant that the act will cure venereal disease. 4. Rape on the Dead, or Necrophilia. — This subject must not be confused with that which deals with the evidence of rape found on the dead body, the crime having been committed before death. The history of this revolting deed extends back through the ages. In the State of New York this crime is punishable by the maximum penalty of twenty years of imprisonment.* Physical evidence of it would be difficult if it were not seen. Several instances of this crime occurred in the old New York city morgue. Statistics. — In my study of 600 consecutive examinations for evidence of rape made in New York, for the Society for the Prevention of Cruelty to Children, I obtained the following statistics: Age: The' yoiongest child was eight months, the oldest eighteen years, and the average age was eleven years. Nativity: 405, or 67.50 per cent., were native bom; 65, or 10.83 per cent., were Italians; 36, or 6 per cent., were Germans; 23, or 3.83 per cent., Russians; 13, or 2.16 per cent., Enghsh; 10, or 1.66 per cent., Austrians; 8, or 1.33 per cent., Irish; 4, or 0.66 per cent., Scotch; 4, or 0.66 per cent., Swiss; 4, or 0.66 per cent., Hvmgarians; 3, or 0.50 per cent., French; 3, or 0.50 per cent., Belgian; and 2, or 0.33 per cent., Bohemian. Marks oj a struggle: I found marks of a struggle in only 15 cases, or 2.50 per cent. These included abrasions, contusions of the thighs, groins, buttocks, shoulder, and arm, 11 cases, or 1.83 per cent.; scratches of the hand and face, 3 cases, or 0.50 per cent.; and black eye in i case, or 0.17 per cent. Condition oj the external genitals: Contusions, abrasions, or lacerations were present in 21 cases, or 3.60 per cent.; vulvo- vaginal abscess in i case, or 0.17 per cent.; chancres or chancroids in 18 cases, or 3.01 per cent.; the fourchette was lacerated in 17 cases, or 2.83 per cent. The hymen was found to have been ruptured in 338, or 57.46 per cent, of cases; inflamed in 7 cases, or 1.19 per cent.; stretched in 11 cases, or 1.83 per cent.; contused in i case, or 0.17 per cent.; and abraded in 2, pr 0.33 per cent, of cases. Secretions: A muco-purulent or purulent discharge was found in 67 cases, or 11. 16 per cent.; the gonococcus was found in 16 cases, or 2.66 per cent.; and spermatozoa in 2, or 0.33 percent. Impregnation, as far as the cases could be followed, was known to have occurred in 22, or 4 per cent. Undoubtedly this is a low percentage, as many cases passed from observation. Penetration of the genital organs by a blunt instrument was considered to have been recent in character in 201, or ^7, per cent.; non-recent, in 180, or 30 per cent., and both recent and non-recent in 5 cases. Penetration was thus determined in 386 cases, or 65 per cent. In 2 cases, because of menstruation and venereal sores, it was impossible to determine whether pene- tration had occurred or not. This leaves 212 cases, or 35 per cent., in which there was no evidence whatever of penetration of the genital organs. VI. HYGIENE OF THE SEXUAL FUNCTIONS. The health of the young girl should be most carefully guarded with a view of preserving the integrity and vitality of the sexual functions. The difference in vigor between the American women and their English and Continental sisters points strongly to the superiority of the habits of hfe of the latter. The vulnera- bility of the female pelvic organs is well known, and most of the dangers attend- ing their treatment in former times have been done away with by modern aseptic technique. The causes of gynecological disease are (i) predisposing and (2) exciting. Chronologically considered, the first predisposing cause is heredity. Heredity. — The untoward results of this factor are seen either in the direct transmission from mother to daughter of specific physical defects, or in general ill health as the heritage of ill-conditioned parents. It is generally accepted that * Rust's "New York Penal Code and Criminal Procedure," 1891, chap, v, p 63, sec 303. clause 4 36 PHYSIOLOGY OF THE FEMALE GENITAL ORGANS. the children of parents of advanced years are apt to be less vigorous than those of younger progenitors. Education. — This has a powerful influence on the genital functions. Great concentration in study uses up the nerve energy of the body and leaves the uterus and ovaries without their legitimate share. Especially does close application to music have a deleterious effect on these functions, by its emotional influences and the expenditure of nervous energy which it demands. Hyperemia of the pelvis, however caused, tends to produce disease of its contained organs. Sexual excite- ment produced either through mental or physical influences — e. g., the observa- tion of obscene sights or pictures, or masturbation — is also a cause. Mode of Life. — Lack of exercise and of outdoor air is a fruitful cause of disease and poor pelvic circulation. In the last few years attention has been called to these defects in the life of the average American girl, and athletic sports, com- paring favorably with those of men, have been instituted. Neglect of the skin as the medium for so much of the vitiated excretions of the body is particularly noted among the poorer class of foreigners. The amount and kind of food exer- cises an important influence on the young girl's health. A common habit, which grows stronger with every repetition, is the omission of breakfast. Soda-water, ice-cream, and candy are most harmful if taken to excess, as they very often are. Indigestible and non-nutritious foods should be avoided. All these factors tend to produce anemia and general ill health. Neglect of the excretions is a very common fault in young girls, as well as in women, and especially those with gynecological troubles. The bowels, instead of moving once or twice a day, as they should normally, are evacuated perhaps once a week. The poisons of the waste matter are absorbed and sapremia results. The circulating impurities show themselves in the anemic appearance, lack of energy, headache, and neuralgic pains.- Then, again, the bladder is often not emptied when it should be; consequently distention and displacement of the uterus by the enlarged bladder, or paralysis of that organ, or cystitis may result. Disregard of the menstrual periods causes much trouble. Girls during these periods are very apt to make no difference in their manner of life from that at any other time. Oftentimes violent exercise and exposure at these periods bring on serious con- sequences. Dress. — The manner of dressing has much to do with health or disease ; it is especially faulty amongst women. Tight garments for any part are most inju- rious. The disproportionate arrangement of clothes as to the warmth they afford is injurious; for instance, when the lower abdomen is not sufficiently pro- tected. Incorrect corsets exert a most baneful effect on the female organism. The old-fashioned garment, even when worn loose, exerts a pressure of thirty pounds (Fig. 36). The abdomen suffers from this more than the thorax. There is a thinning and weakening of the abdominal wall, which becomes relaxed and pushed forward, in the upright position, by the liver and intestines. In the sitting posture, the pressure exerted by the abdominal wall, which should be backward against the spine, is exerted downward toward the pelvis, and causes bulging of the vulva even to the extent of half an inch (1.27 cm.). Corsets made to sup- port the lower abdomen have not these objections (Fig. 37). High heels should be avoided, for when they are worn, especially by the young, whose bones and articulations are soft and pliable, they not only distort the foot but often en- gender other troubles, such as neuralgic pains in the legs, alterations in the shape of the pelvis, and curvature of the spine. Ordinary social pleasures entailing late hours have a very bad effect on a girl's nervous organization. Sexual Life. — Normal sexual intercourse, even when frequent, is not apt to HYGIENE OF THE SEXUAL FUNCTIONS. 37 injure a healthy woman. But irregularities indulged in will bring in their train many complaints. Marriage, if pelvic disease exists, is often attended with dire results, and causes much misery to both husband and wife. The growth of fibro- mata seems especially active in the uteri of unmarried women and in those who have never borne children. It would seem that the energies of that organ, which are normally applied to the formation of a child, being deprived of that object, • are free to take part in the production of a new growth. The Prevention of Reproduction. — The act of reproduction may be set at naught in a twofold manner: (i) By conditions which prevent the union of the Fig. 36. — Corset Improperly Titted, so THAT Abdominal Contents are Pushed Downward and Backward, thus Fa- voring Posterior Uterine Displace- ments. Note the unnatural pressure upon the breasts. — (Photographed from life.) Fig. 37. — Properly Fitting Corset. Hy- pogastrium Supported from Below Upward. Breasts Free and only their Lower Portions Supported. — (Photographed from life.) reproductive units, and (2) by death of the embryo which results from the union of these units. I. Non-impregnation. — When non-impregnation comes about solely through conscious efforts of the participants, we have a condition of affairs known as artificial sterility, a subject which has a distinct obstetrical significance, because in order to save the Hves of certain women, and at the same time to avoid feticide, it is justifiable to prohibit impregnation. Unless either the life or the health of the woman is certain to be wrecked by bearing a child, or unless she is incapable of giving birth to a normal living child, the prevention of impregnation is justly regarded as a violation of the moral law, an injury to the State, and to a certain extent a detriment to the health of the participants. Technically, at least, it is a 38 PHYSIOLOGY OF THE FEMALE GENITAL ORGANS. violation of the criminal code, the various contrivances used for the prevention of conception being regarded as contraband. A sharp distinction should there- fore be made between artificial sterility which is practised to save the more ' valuable life, and that which simply seeks to prevent reproduction in itself. Therapeutic Prevention. — This expression signifies the prevention of impreg- nation in cases in which the reproduction of a healthy, living child is quite impos- sible, or if possible would mean either the death or permanent invalidism of the^ mother. Indications. — These comprise: (i) General conditions in the mother which are likely to be transmitted to the child — syphilis, the tuberculous dyscrasia, insanity, epilepsy. (2) General conditions in the mother which would be aggra- vated to such an extent by reproduction that her death would be determined, or, if inevitable in any case, greatly accelerated — heart disease, tuberculosis, cancer, nephritis, diabetes, etc. (3) Conditions in the mother which, by producing extreme dystocia, would make Caesarean section the only route by which the child could be born — high degrees of contracted pelvis, obstruction of the birth tract by inoperable tumors. Management. — In the case of a woman who furnishes any of the indications just enumerated, it is the duty of the physician to inform the patient and her husband of all the consequences of impregnation under the circumstances. If the matter is left to him to decide, he must insist that conception shall not occur. Much further than this he can hardly go. Realizing that cohabitation without intercourse is a condition difficult to realize, he may suggest a separation, tem- porary or not. If this is refused, coitus might be permitted during the so-called agenetic period of the intermenstrual cycle (from the seventeenth to the twenty- fourth day after cessation of a period). The married pair should be informed that this precaution simply diminishes the risk, and that if the lS,tter is assumed, impregnation, if it occur, will necessitate interruption of the pregnancy, which will submit the mother to more or less danger, hardship, expense, etc. If the matter is left to the physician, he can hardly sanction coitus under any circum- stances. Sooner or later the question will arise as to the use of so-called illegiti- mate measures of preventing conception. If asked the objections to these, he must take the stand that every one of these preventive measures constitutes an abuse of a normal function. The coitus interruptus, coitus reservatus, simple or antiseptic douching after coitus, wearing of coverings for the penis or obturators for the uterus, etc., are all unphysiological and many of them untrustworthy. A physician can never sanction anything which is frankly unphysiological, and should explain to his patients that the act. of intercourse consists in three distinct stages: (i) The male organ becomes completely rigid, passing from a state of flaccidity into erection. (2) The second stage comprises intromission, friction, and the orgasm or crisis. (3) The act of copulation is not concluded by the orgasm. The penis, therefore, should not be withdrawn at once, but allowed to remain until the gradual subsidence of the erection leaves it in its original flaccid state. This final stage of copulation undoubtedly plays an important role in impregnation, and if it is shortened or omitted, the consequences appear to be unpleasantly felt by both sexes. In other words, withdraw^al of the penis immediately after the orgasm is virtually a coitus interruptus. It is character- istic of the various illegitimate measures for preventing conception that all of them interfere with the second or third stage of coitus. The consequences to the woman of these illegitimate practices are in part: (i) An unnatural local congestion which leads to oophoritis, endometritis, leucorrhea, dysmenorrhea, sterility, metrorrhagia, and cancer of the uterus; (2) neuroses of various kinds, HYGIENE OF THE SEXUAL FUNCTIONS. 39 spinal irritation, neurasthenia, etc. In the man the consequences are similar in character, with the addition of dissatisfaction with imperfect coitus with his wife, which often foments dislike, unfaithfulness, marital infelicity, and divorce. If impregnation is actually contraindicated in a given case, the practitioner can- not recommend any of the illegitimate modes of prevention of conception because they are either harmful, or untrustworthy, or both. There is, however, one course possible, which may be recommended as both safe and efficacious, and one which can hardly be abused. That is, obhteration of the Fallopian tubes for a short extent by the vaginal route. This course is unobjectionable in theory from any standpoint; yet I fear it hardly constitutes a solution to the problem. 2. Interruption op Pregnancy. — After pregnancy has begun it may be in- terrupted by the natural death of the fetus from disease, trauma, etc. This is con- sidered under the heads of death of the fetus, abortion, etc. (Part III). Preg- nancy intentionally ended is feticide. Criminal feticide is the destruction of fetal life for no other reason than to avoid child-birth. This is considered under the head of criminal abortion (Part III). Therapeutic feticide, on the contrary, con- sists in taking the fetal life when non-interference with pregnancy would result in the death or permanent invalidism of the mother, or the birth of an abnormal unit of society. The subject of therapeutic feticide is considered under " Ob- stetric Operations " (Part X). Child-birth. — Child-birth not infrequently is the origin of disease of the pelvic organs, which hinders or prevents their normal functions. These troubles may or may not result from improper medicinal or surgical treatment. Abortion is a fruitful cause of pelvic trouble. Puerperse should receive the most careful attention, and should be kept in bed till the uterus has contracted back into the pelvis. In order to avoid the perils of gonorrheal and syphilitic infection, these subjects are now receiving like attention with tuberculosis. The application of the general principles of aseptic midwifery and early operative measures in case of delayed labor, with immediate surgical attention given to lesions of the soft parts, are doing much to prevent the frequent pelvic troubles so common in former years. . Climacteric. — The climacteric, although a physiological process, is a period during which various diseases may show themselves. Nervous phenomena are among the most common disturbances. The most serious occurrence is the appearance of carcinoma, either in the uterus or in the breast. During this period the bowels should be kept open. Cold bathing followed by brisk rubbing, and lukewarm baths taken at intervals of a few days, tend to calm the nerves. The diet should be carefully supervised. The patient should be supported men- tally and encouraged by a favorable prognosis. In case of hemorrhage, it should be checked just as in ordinary cases. Cancer. — There is little possible prophylaxis at present for malignant disease of the pelvic organs, but there is hope for the future. As. soon as the true cause of cancer is discovered, some method of preventing or at least arresting its progress will present itself. Family Physician. — The family physician should be the guide of the child from infancy through the various stages of life up to womanhood. He should instruct not only the girl, but her mother also, in regard to the importance of the sexual organs, their functions, and their proper care. The generative organs are the last to develop, and when the girl is deficient in vitality these organs are the first to suffer, for when undeveloped they are most prone to disease. PART TWO, Physiological Pregnancy* PHENOMENA PRODUCED BY PREGNANCY WITHIN THE UTERUS. (Page 41.)— The Ovum; Maturation; Fertilization; Primitive Chorion; Deciduse; Segmentation; Qerm=layers; Primitive Organs; Origin of Mem- branes; Amnion; Allantois; Chorion; Placenta; Umbilical Cord; Nutrition and Metabolism of the Ovum, Embryo, and Fetus ; Characteristics during the Several Lunar Months ; Evolution and Determination of Sex. II. PHENOMENA PRODUCED BY PREGNANCY IN THE MATERNAL OR- GANISM. (Page 89.) — Local Phenomena in the Genital Tract, Adnexa, Pelvis, and Breasts; General Phenomena in the Digestive System, Heart, Lungs, Liver, Nervous System, Blood, Urine, Skin, etc. III. THE DIAGNOSIS OF PREGNANCY. (Page 119.) IV. THE DIFFERENTIAL DIAGNOSIS OF PREGNANCY. (Page 132.) V. FEIGNED PREGNANCY— PSEUDOCYESIS. (Page 138.) VI. UNCONSCIOUS PREGNANCY. (Page 139.) VII. MULTIPLE PREGNANCY. (Page 140.) VIII. THE DURATION OF PREGNANCY. (Page 144.) IX. CALCULATING THE DATE OF CONFINEMENT. (Page 146.) X. THE EXAMINATION OF PREGNANCY. (Page 148.)— Obstetric Asepsis of Patient and Physician ; Objects, External or Abdominal ; External Pelvi- metry; Internal or Vaginal; Internal Pelvimetry; Rontgen Pelvimetry; Pelvigraphy; Indirect Pelvimetry; Cliseometry; Cephalometry. XI. THE HYGIENE AND MANAGEMENT OF PREGNANCY. (Page 184.) — Prophylaxis; Exercise; Diet; Drink; Bowels; Fresh Air; Care of Skin, Clothing, Breasts ; Mental Condition ; Examination of Urine ; Sexual Intercourse. I. THE PHENOMENA PRODUCED BY PREGNANCY IN THE UTERUS. THE DEVELOPMENT OF THE OVUM, EMBRYO, FETUS, FETAL MEMBRANES, AND FETAL STRUCTURES. Introduction. — Pregnancy begins with conception and normally ends with labor at the fortieth week. If no complications arise during this time, we have a physiological pregnancy (Part II). On the other hand, various accidents may bring about a pathological pregnancy (Part III). A nulliparous woman, or a nullipara, is one who has never borne a child, and the condition is one of nulliparity; A primigravidous woman, or a primigravida (or primipara), is one who is pregnant for the first time, and in subsequent pregnancies she is known as a multigravidous woman or a midtigravida (or multipara). Different degrees of gravidity or parity are usually designated by the Roman numerals, thus: Ipara, a woman in her first pregnancy; Ilpara, one in her second pregnancy; Illpara, IVpara, Vpara, etc. In the following review of the subject of embryology, emphasis is placed upon the growth of the embryo, fetal membranes, and fetal circulation — facts which bear most directly upon the subject of obstetrics. For a full consideration of the subject special works on embryology should be consulted. Among these, Minot's discussions of difficult points are valuable, while the most recent book with an almost exclusive bearing upon human embry- ology is KoUmann's " Entwickelungsgeschichte der Menschen." The embryological part of Quain's "Anatomy" and Hertwig-Mark's "Embryology" also give excellent accounts of the subject. For the latest information one must refer to the monographs which are appear- ing in scientific periodicals. His's monumental work* is the source of the greater portion of the accurate informa- tion on the sub j ect of human embryology. The phenomena of the development of the human being in its earliest stages have not been adequately worked out; hence the gaps in knowledge are usually filled in by statements from com- parative embryology. We shall endeavor to differentiate what is known of human development from that which is ■ y,-^ inferential. \\|x The Ovum. — At birth the ovary of a child is ''^'^^-, ua believed to contain the maximum number of ova, "^ ~ -or~ "-' estimated as high as 70,000. These primordial ova Fig. 38. — Primitive Folli- are typical, spherical cells containing a nucleus ^^ ^^^^l. "^"^ ^^J^'^V^^^t . , •'^ ' ^ . ,*',,. .„. Woman Thirty-two Years with a membrane and one or several nucleoli (rig. Qld. th, Connective-tissue 38). They are arranged in so-called egg-tubes of layer; theca folliculi ; /, epi- Pfluger and egg-nests (Fig. 39), which extend for t^f^^i', '^^^S. some distance into the body of the ovary. By or germinative vesicle. — the gradual ingrowth of vascular connective- tissue {Ajter W. Nagel.) between the individuals of the tubes and nests the ova are separated and become entirely surrounded by a connective-tissue sheath the theca folliculi. Thus are formed the primitive follicles which at a later stage * "Anatomie menschlicher Embryonen," 18S0-18S5. 41 ^^ ^^f^ ■^ ■J-V^ v^ t 'Ov 42 PHYSIOLOGICAL PREGNANCY. of development are known as Graafian follicles (Fig. i). As the ova develop they increase in size until at maturity they are about y-^ inch (0.2 mm.) in diameter, surrounded by a porous membrane, the zona pellucida or radiata; this in turn is surrounded by a several-layered follicular epithelium known as the corona radiata. A cell membrane limits the ovum proper, between which and the zona pellucida there exists a narrow fissure known as the perivitelline space The cell body, or vitellus, is protoplasmic and contains a few granules of food- yolk similar to that which forms so marked a feature of the hen's egg. On account of this small amount of food-yolk, or deutoplasm, the mammalian egg is said to be alecithal (without yolk), in contradistinction to telolecithal eggs, as best exemplified by Amphibia and birds, where the nutritive yolk is massed J^S KE PS Fig. 40. — Full-grown Human Ovum before Maturation. A spherical cell with nucleus, nucleolus, and yolk granules, z.p.. Zona pel- lucida; y. ox v., yolk or vitellus; g.v., germinal vesicle with nucleolus; cr., corona radiata; pz., protoplasmic zone of ovum; p.s., perivitelline space. — (After Nagel.) Fig. 39. — Development of Graafian Follicle of Mammals. D, Cumulus oophorus; Ei, ripe egg with its germ i- native vesicle and germinative spot (K); Ke, germinal epithelium; Lf, liquor folliculi; Mg, stratum granu- losum; Mp, membrana pellucida ; Ps, Pfluger's tubes; 5, fissure between follicular cells {G) and cumulus oopho- rus; 5o, connective-tissue stroma with blood-vessels (g); Tf, theca folliculi; V, V, primitive follicles. — {After Wie- dersheim.) at one pole; and centrolecithal eggs, as exemplified by Arthropods, where the deutoplasm has a central position. The nucleus becomes somewhat eccentrically placed and contains a conspi- cuous nucleolus (Figs, i and 40). The whole ovum is encapsuled by the Graaf- ian follicle. The follicles are scattered at different levels throughout the stroma of the ovary (compare Ovulation, page 17). Maturation of the Ovum and Zoosperm. — In many of the lower animals a process called maturation of the ovum has been observed, whereby the nucleus migrates toward the surface and by an active process of division throws off a part of its substance in the form of polar globules, the part remaining in the cell being called the female pronucleus or egg nucleus. PHYSIOLOGICAL PREGNANCY, 43 Polar bodies in different stages of development have been found in the eggs of mammals (Figs. 41 and 42), and we may reasonably infer that a similar pro- cess transpires in the human ovum. As the result of a somewhat analogous process of maturation and division, the zoosperm or mature male element (Fig. Fig. 41. — Formation of Polar Globules, Mouse. Showing the nucleus of the ovum dividing to form the first polar globule, p.g., and at the right a zoo- sperm, s, which has entered at the pro- jecting portion. — (After Sobotta.) Fro. 42. — Fertilization in the Mouse Showing an ovum with two polar globules and the male and female pronuclei about to unite; g. s., achromatic spindle.^ (Ajier Sohotta.) 'y^ Fig. 43. — Ovum of White Mouse. First segmen- tation spindle with the chromosomes of the pro- nuclei still forming two distinct groups. X 1500 diams. — {After Sohotta.) Fig. 44. — Ovum of White Mouse. First segmenta- tion spindle with equa- torial plate of chromo- somes. X 1500 diams. — {After Sobotta.) Fig. 45. — Ovum of White Mouse. First segmenta- tion spindle. The chro- mosomes have divided and migrated toward the poles of the spindle, form- ing two groups. X 1500 diams. — {After Sobotta.) 8) contains a nucleus, — the male pronucleus, or sperm nucleus, — which repre- sents only a part of the original nucleus from which it was derived. Fertilization or Impregnation. — When the two sexual elements come in contact in the upper part of the Fallopian tube, the zoosperm enters the ovum, where its body becomes indistinguishable (Fig. 42), and a union of the two 44 PHYSIOLOGICAL PREGNANCY. pronuclei takes place. This is considered the essential step in fertiHzation, the union giving rise to a new nucleus called the segmentation nucleus. In the ovum of the white mouse, according to Sobotta, the pronuclei never actually fuse to form a membranate segmentation nucleus. Here the pronuclei lie first in close apposition and are then separated by the formation of the achromatic spindle (Fig. 42). The pronuclei now break up into chromosomes and arrange themselves first into two groups about the spindle (Fig. 43) and then into an equatorial plate (Fig. 44). At this stage there occurs a longitudinal splitting of the chromosomes and a consequent doubling of their original number. The chromosomes next draw apart toward the two poles of the spindle (Fig. 45), where, after the completion of the first segmentation, they give rise to the nuclei of the resulting cells. It is now believed that a similar process of fertilization takes place in all mam- malian ova. Facts of this sort have great bearing upon theories of heredity, ■)•■■■ Fig. 46. — Transverse Section of the Uterus from a Six-months' Fetus AT THE Level of the Internal Os. I, Cylindrical ciliated epithelium; 2, connective-tissue stroma of mucous membrane containing blood-vessels; 3, muscular layer with arteries; 4, sub- serous connective tissue; 5, peritoneal endothelium; 6, intraligamentary connective tissue, containing main branches of uterine artery. — {Schaej- jer.) Fig. 47. — Uterus and Ovum at Seventh or Eighth Day. Section through Fig. 48. o, Decidua vera; b, d, decidua reflexa; c, ovum; o.i., internal os. — {Leopold.) because it is evident that the actual sub- stance derived from both parents goes to form the new individual and appar- ently is distributed by subsequent nuclear division to every portion of the body (see Impregnation, page 29). Primitive Chorion. — During its passage through the Fallopian tube the ovum derives more or less nourishment from the parts by which it is surrounded. This is accomplished at a very early period by the formation upon all of the extra-embryonic somatopleure of a growth of delicate villi which give to the ovum even at this time a shaggy appearance. This is the primitive chorion, and the whole ovum at this time is called the chorionic vesicle. The Deciduae. — The uterus prepares for the reception of the fertilized ovum by the premenstrual swelling of its mucosa which forms a pulpy nidus for its new occupant. If the fertilized ovum does not then appear, menstruation takes place. If the fertilized ovum remains in the genital tract, then the uterine PHYSIOLOGICAL PREGNANCY. 45 mucosa undergoes changes by which it is converted into decidua. That formed in pregnancy is called decidua gravidilaiis. The normal uterine mucosa is thin, averaging from 0.039 to 0.117 inch (i to 3 mm.) in thickness. Its most marked change in pregnancy is the increase in this dimension, for in this condition it often attains -g- inch (i cm.) in thickness. It is very vascular, soft and velvety in consistence, and its surface is wavy or undulating, studded with depressions which correspond to the openings of glands. With the beginning of pregnancy the decidua comprises three parts : ( i ) Decidua vera is the hypertrophied mucous membrane of the entire uterus (Figs. 47, 48, and 49). It atrophies in the last third of pregnancy and is cast off in part with the membranes at labor and in part with the lochia. (2) Decidua serotina, placental serotina or decidua basilis, is that part of the decidua vera upon which the ovum is embedded and which subsequently takes part in the formation of the placenta (Fig. 47). (3) Decidua reflexa, circumfiexa or capsularis, or epichorial decidua, is not, as its original name indicates, reflected, but is formed by growth of the uterine tissues over the ovum till they meet above its surface (Figs. 47 and 49). This Fig. 48. — Uterus and Ovum at Seventh or Eighth Day, showing Decidua Vera. o.i, Internal os; a, uterine wall. — (Leopold.) process of reflexion is nearly completed in the youngest human ovum, Peters 's (Fig. 51), and is quite finished in from eight to twelve days after the migration of the ovum into the uterus. The capsule grows with the increase of the ovum until the second month, when it begins to degenerate, disappearing entirely by the seventh month (Fig. 53). Theories of the Origin of the Decidua. — There have been various theories concerning the decidua. In 1840 Weber and Sharpy demonstrated glands within it and showed it to be a hypertrophied mucosa. Friedlander's ideas concerning the structure of the decidua are, in general, correct. He found therein glands lined by high, columnar, ciliated epit;helium. The decidua vera comprises two layers; the upper layer, or stratum compactum, consisting of decidual cells with gland ducts here and there, while the attached layer, or stratum spongiosum, is of spongy consistency, and made up of a few decidual 46 PHYSIOLOGICAL PREGNANCY. cells, blood-vessels, and dilated glands or cavities.. Friedlander believed that at the end of pregnancy the compact layer is thrown off; while there is left the / '..'^Si^ V5:>;/T(V Cih:: ■ y^'^.'-z'r-^-^--^M^^^. Fig. 49. — Microscopic Section through an Ovum in Situ at the Seventh or Eighth Day, showing Uterine Wall, Decidua Vera and Reflexa. — (Leopold.) Fig 50. — Uterus and Ovu.m at Two Weeks, o, Ovum; d, decidua vera; o.i., internal os; 5, external os. — (Leopold.) spongy layer, which is the dilated, irregular surface usually seen. It is now known that the line of demarcation is somewhat deeper than Friedlander be- lieved. His work has been verified by Leopold and Meinert. PHYSIOLOGICAL PREGNANCY. 47 ""'" %^'0^^^^^S&iSi:frioni^eye Fig. 94. — Schematic Representation of Early Embryonic Structures. is not completed on the ventral side. This interval is completed by the simple layer of ectoderm forming Rauber's layer. The modification is still further emphasized by the atrophy and disappearance of the cells of this layer. The facts just stated have given rise to many ill-founded theories with regard to human development; thus, Rauber's layer was supposed to have no relation to the true ectoderm, and as the entoderm seemed to come to the surface, it was supposed that there was a so-called "inversion of the germ-layers." Fig. 95. — Human Ovum Twelfth to Thirteenth Day. — {Reichert.) Another modification of the membrane-formation which has been used to explain the condition in man is well illustrated in the mouse and some other rodents. The heap of cells at the pole first differentiates off a few entodermal cells which multiply and form a layer. A cavity then appears in the ectodermic portion of the mass of cells which enlarges so greatly as to form a sac nearly covered by the ectodermic layer, the whole extending far into the interior of THE MEMBRANES AT TERM. 65 the outer or Rauber's layer of the ovum. The embryo is formed at the deepest portion of this invagination. The amnion is produced by the growing together in an hour-glass-Uke formation of the invagination over the back of the embryo; the remaining portion next the original implantation of the heap of cells becoming the chorion and finally a part of the placenta. Here, too, the remaining portion of the ectoderm in Rauber's layer does not apparently become a part of the chorion. Contrary to the condition in the chick, rabbit, and many other mammals, the allantois of the mouse does not form a large pouch of ento- derm, but is a small tubular invagination of the yolk-sac. It is, however, covered by mesoderm, which continues as a sheet over the chorion and carries the blood- vessels of the embryo to the placenta, where the blood is aerated. In Peters 's embryo, the youngest human specimen studied, it is seen that the conditions are not as in the chick, with early formation of embryo and sub- sequent differentiation of membranes; nor as in the rabbit, nor even quite as in the mouse. The membranes in Peters's embryo have been developed preco- ciously (Fig. 51). The chorion is a completely closed sac with amesodermic lining, such as occurs quite late in the chick. There is no sign of the disintegration of the outer ectodermic layer, as in the Rauber's layer of the rabbit, but later stages (according to Mall) indicate that it becomes transformed into the syncy- tial layer of the chorion {q. v.). The amnion is also a closed sac with the un- differentiated embryo, a simple thickened plate of cells, lying in its deepest portion, thus having a strong resemblance to the early condition in the mouse. The yolk-sac is also closed and is larger than the amnion, but is not constricted with any indication of an alimentary tract, as would be the case in the chick at a similar stage of development with reference to the mesoderm. The latter has, indeed, attained a remarkable development. It has entirely invested the yolk-sac forming the splanchnopleure, while the somatopleure is represented by the amnion and the chorion completely invested by the mesoderm before there is an indication of the formation of somites. Whether the amniotic sac becomes hollowed out of a solid mass of cells, as seems to be the case in the mouse, or whether there is only a division of the amnion from the chorion, such as occurs in the rabbit (as surmised by His and Nagel), although taking place relatively earlier, cannot be determined without further investigation. In Graf Spec's embryo (Figs. 65 and 66), and in an ape examined by Selenka, an appear- ance is found which points to the latter conclusion ; since the amnion in these speci- mens has a diverticulum pointing toward the chorion, as though just constricted off therefrom. The important point in this connection is that the amniotic sac never separates completely from the chorion as with the rabbit, but remains connected with it by a broad band of mesoderm. In the next later stages of human embryos it is found that a small diverticulum of the yolk-sac extends into this mass of mesoderm, which has become relatively smaller, forming the stalk which with further development becomes the umbilical cord. Although a true allantois — in the sense that it occurs in the chick and many mammals — is not present, the mesodermic layer of that organ may be said to exist; since the blood-vessels, when they arise, pass by way of this allantoic rudiment through the abdominal stalk to the chorion. To sum up, but that this earliest human ovum, before an embryo has even been outlined, has membranes of a stage of develop- ment corresponding to a much later stage in the chick, a closed chorion, a closed amnion, a closed yolk-sac. The essential difference is that there is no free allan- tois containing an extensive entodermic cavity, and that the mesoderm con nects the embryo with the chorion from the earliest stages and not secondarily. The Membranes at Term. — At term the fetus is surrounded by three mem- 5 66 PHYSIOLOGICAL PREGNANCY. branes, two of which are of fetal and one of maternal origin. Their order, from within outward, is: amnion, chorion of fetal origin, and decidua refiexa and vera of maternal origin. The Amnion. — As seen above, the amnion is the innermost of the fetal mem- branes. At first it encloses only the dorsal part of the embryo, but with growth and closure of the body- wall around the umbilicus, it completely invests the embryo except that the cord passes through it. It is continuous with the fetal epidermis at the umbilicus (Figs. 65, 66, 67, 93, and 94). It consists of two layers, one of flattened cells derived from the ectoderm and continuous with the epidermis, the other of connective-tissue cells and fibers, mesoblastic in origin. The enclosed space constitutes the true amniotic cavity or sac, and its chief function is the secretion of liquor amnii. At first the amnion, as com- pared with the embryo, is quite large. Then the embryo grows more rapidly and the amnion closely invests it ; and finally at the second month a more rapid growth of the amnion takes place, which ultimately re- sults in a close relationship between it and the chorion. As long as a cavity exists be- tween amnion and chorion it is sometimes called the false amniotic cavity and is filled with a liquid somewhat sim- ilar to the amniotic fluid. At birth the bag of waters con- sists of the amnion and part of the chorion. Sometimes this is not ruptured until after the head is born. Liquor Amnii. — The am- niotic fluid contained in the amniotic sac is somewhat variable in quantity, the aver- age being about a liter, or quart. Of this, nearly one- half is formed during the last three lunar months. At times this fluid is very scanty, so that it interferes with the growth of the fetus, and causes its premature expulsion. There is on record a case in which, in the absence of a normal supply of liquid, ulcers were formed on the knees and ankles of a fetus, due possibly to friction. Many other deformities have been found to be correlated with the same condition. When its amount is exces- sive, the condition is called hydramnios, in which many quarts of fluid may be present. The amniotic fluid is alkaline in reaction. Its greatest bulk — nearly 99 per cent. — consists of water, in which are found albumin; creatin; epithelial cells from the fetal skin, bladder, and kidneys; sebaceous material; urea and several inorganic salts (phosphates, chlorides); as well as many other constituents. Its specific gravity varies between 1.0005 and 1.0082. It is generally opaque, white in color, although this may change from the presence of unusual ingredients, meconium giving it a dark brown tinge, while a macerated fetus colors it red. It has a heavy and characteristic odor. Keim has found that the freezing-point of this fluid is higher at term than that of the maternal p.m. y.s. Fig. 96. — Ruptured Human Ovum Fifteenth to Eighteenth Day. Amnion has been opened, a.s., AUantois stalk; p.m., parietal mesoblast; y.s., yolk- sac; a., amnion; h., heart. — {Coste.) THE LIQUOR AM NIL 67 or fetal blood-serum. This indicates an intrinsic tendency to absorption. Its origin is a moot question. The theory that it consists chiefly of fetal urine is disproved by chemical analysis, only a small part arising from this source. The fetal tissues contribute a small portion by exudation. The greater part is of maternal origin and the result of transudation through the placenta. The investigations in regard to the two sources of the amniotic fluid have been as varied as they are interesting. As to the excretion of urine by the fetus, there seems to be undeniable evidence, more than three pints of this excretion having been found in the fetal bladder. After the communication between the bladder and the exterior of the body is completed through the agency of the urethra, there is from time to time a passage of the renal secretion from the fetus into the amniotic fluid. At just what stage of fetal development this occurs has not yet been decided. This prenatal urine is very poor in coloring-matters, as may be seen from the specimens collected soon after birth. Another theory Fig. 97. — Isolated Terminal Branch of Fig. Villus from the Chorion of an Embryo of Twelve Weeks. — (Minot.) : .