cyo On I miljeCtipofBfttigtfrk LIBRARY Digitized by the Internet Archive in 2011 with funding from Open Knowledge Commons http://www.archive.org/details/inauguraldissertOOonde J\/'.'2'//<;/,,,, P Jiiizarj'a, Jjlffioh'my. AN INAUGURAL DISSERTATION ON STONE IN THE BLADDER. Submitted to the public Examination of the Faculty of Physic under the Authority of the Trustees of Columbia College, in the State of New -York, The Right Rev. BENJAMIN MOORE, D. D. President? FOR THE DEGREE OF DOCTOR OF PHYSIC, On the 13th Day of November, 1810, BY HENRY U. ONDERDONK, A. M. Member of the Royal College of Surgeons, London. " The ancients only laid the foundation, which was doing considerable service : they who have come after them, have worked upon their plan, and from time to time, the art of Surgery has received improvements." Gataker's Translation of Le Droll's Operations, I $eto*Iorri: Printed by T. & J. SWORDS, Printers to the Faculty of Physic of Columbia College, No. 160 Pearl-Street. 1810, &OLXJMBXA3XA. v A " tL i' '{ A- "C^^z^C^Z TO DOCTOR JOHN ONDERDONk AS A TRIBUTE OF FILIAL DUTY AND GRATITUDE TO WRIGHT POST, ESQ. Professor of Anatomy and Surgery in Columbia College, and Surgeon to the New- York Hospital, AS A TESTIMONIAL OF RESPECT AS AN INSTRUCTOR 5 AND OF ESTEEM AS A FRIEND; AND TO THOMAS BLIZARD, ESQ. Fellow of the Royal Societies of London and Edinburgh, and Surgeon to the London Hospital, AS AN ACKNOWLEDGMENT OF PROFESSIONAL AND PERSONAL CIVILITIES; THIS DISSERTATION 15 RESPECTFULLY INSCRIBED ADVERTISEMENT. T. HE author of the following pages was led to select his subject from having witnessed at the Hospitals in London, the frequent use of a bistoury in lithotomy ; and from a convic- tion, that it was an instrument superior in principle to any other he had seen used. But to have merely dwelt upon the merits of the knife, would not have afforded matter suffi- cient for an Inaugural Dissertation of reason- able length. He has therefore given a general history of the disease, for whose removal the instrument is proposed. He is sensible that much of this is mere selection; but he has endeavoured to quote from such authorities as are standard, and to adduce only such facts and observations as are of importance. These, he trusts, will compensate for any deficiency In his own remarks. Nassau-Street, Oct. 2, 1810. on STONE IN THE BLADDER. CALCULOUS concretions are found in many parts of the body; but their most usual situation is in the urinary organs ; in the kidney, ureter, blad- der, prostate gland, urethra, and around the corona glandis. The nature of those found in the bladder, the symptoms they occasion, and the methods of relief, are the subjects of the present dissertation. Calculi in the bladder vary in size, number, and composition. The most usual sizes are between those of a musket ball and a hen's egg. But they are sometimes much larger. At the lectures of the Royal College of Surgeons in London, a stone is exhibited, which weighs 44 oz. and is 16 inches in one circumference, and 14 in the other. An at- tempt was made to extract this b y S i r Jamoo fcafte-, but he, of course, failed, and the patient died from consequent irritation. Calculi are sometimes much smaller than the size above limited. Commonly there is but one calculus in the blad- der, Much variety however in this respect is met 8 with. I have seen two sets, one of 37, and another of 22, each taken from a single bladder. Dessault extracted 200 from one bladder,* which were most probably small. Mr. Home relates an instance of 350 from one patient. f When more than one exist, their surfaces are smooth. Cheselden gives a plate of two from one bladder, which had opposing smooth surfaces like a joint: J they had probably been re- tained in the bladder in such a situation that their friction upon one another was confined to these sur- faces. Dr. R. S. Kissam showed me a single cal- culus with a small part of its surface polished, which he attributed to its lying constantly upon an enlarged prostate. Mr. Brande, in a paper published in the Philoso- phical Transactions for 1808, § has arranged urinary calculi into three kinds : Those composed chiefly of uric acid ; those made up chiefly of an ammoniaco- magnesian phosphate, or of phosphate of lime, or of both ; and those which contain oxalate of lime^ called also mulberry calculi. The first kind are those passed from the kidney out of the body, without remaining in the bladder at all, or only a short time. They consist of uric acid and animal matter, in proportions varying from nearly equal quantities of each, to two thirds of the former. This species are soluble in alkalies, and disappear before the blow-pipe: they have smooth surfaces, and are made up of concentric layers like a section of a tree; their colour is commonly brown s * Parisian Journal, vol. ii. p. 386. f Philosophical Transactions, 1808, page 244. - Cheselden's Anatomy, edit. 1.722, plate SO ; ) Page 223. 9 I have, however, seen them white. Dr. G. Pearson, in a paper of the Philosophical Transactions for 1798,* terms the acid which constitutes the base of this kind of calculus, uric oxide: he asserts that it is only found in the human subject, and may be dis- covered in gouty concretions, but not in those of the teeth, stomach, intestines, lungs, brain, &c. He notices some analogies which induce him to be- lieve, that, if man lived on vegetables alone, he would not have this oxide formed in his body.- — The first detection of uric acid by analysis of urinary calculus was by Scheele. The next division made by Mr. Brande, compre- hends such calculi as are principally made up of the ammoniaco-magnesian phosphate, or of phosphate of lime, or of both. These substances, he asserts, are met with when the stone has been some time in the bladder, or when a stone is detained longer than usual in the kidneys. These are commonly the most abundant ingredients in a large calculus. They are generally mixed with the uric acid, either in dis- tinct layers, or by mechanical diffusion. Calculi formed of these alone, are found in the bladder only, and have some loosely agglutinated particles of the same matter for a nucleus. The colour of calculi of this species is a whitish grey; their surfaces fre- quently exhibit transparent crystals ; they generally are firm, but not unfrequently so friable as to crum- ble under very slight pressure; they are soluble in muriatic acid. They are thought to be connected with greater disease of the bladder than either of the other species. Page lc 2 10 The last division of Mr. Brande contains the few specimens which exhibit on analysis oxalate of lime. These are found only in the kidney, or are immediately passed thence. If they have been re- tained in the bladder, they are only nuclei for some other species. When they are passed immediately out, the patient is less liable to a return of the com- plaint. The surface of this species of stone is rough, not unlike the fruit to which it is compared; they are firm in texture, and difficultly soluble in acids. The following is the result of the analysis of 150 calculi, made by this chemist. It exhibits the pro- portional frequency of the several species, and may afford some useful hints in considering the means proposed for dissolving a stone. 16 consisted of uric acid ; 45 of uric acid as the larger, and the phosphates as the smaller ingredient ; 66 of the phosphates as the larger, and uric acid as the smaller ingredient ; 12 of the phosphates alone; 5 of uric acid and the phosphates, with a nucleus of oxalate of lime; 6 of oxalate of lime chiefly. The analysis of urinary calculi was extended by Mr. Brande to those found in the brute creation, Specimens from the horse, ox, sheep, dog, hog, rabbit, and rhinoceros were examined; and the grand difference between them and the human, was, that they contained no uric acid, but carbonate of lime very generally, an ingredient not discovered in the human specimen? 11 SYMPTOMS. A patient generally first experiences an itching or smarting sensation about the frenum. This induces him to rub the part frequently, and the prepuce is thus sometimes preternaturally elongated. When very violent, the sensation has been compared to cutting with a red-hot knife. A frequency in making water, together with pain, is soon observed; and this pain is particularly great while voiding the last drops, during which the bladder contracts firmly upon the stone, and undergoes excessive irritation. The pain at the glans is most acute, from that part being a centre of sympathy for the bladder and ure- thra; that in the region of the bladder is of a more dull nature. A more remarkable and more certain diagnostic of the disease, is an irregularity in passing the urine. It first flows in a full stream, and then is suddenly stopped. This arises from a falling (as it is usually termed) of the stone against the mouth of the ure- thra. But the obstruction is rather caused by the stone being raised to this point, from the lower pos- terior bulging part of the cavity ; into which its own gravity will incline it to subside, and which becomes obliterated while the bladder is contracting to void the urine : when the stone is raised to the point men- tioned, it will be disposed to remain in the funnel- like cavity, until a new distention of the bladder allows it to subside to its first situation. This symptom occurs also in that disease of the prostate, where a part of that gland is made to project into the bladder. Agitation greatly increases the pain from a stone. Riding in a carriage or on horseback will occasion excruciating torture, and not unfrequently cause the urine to be tinged with blood. If the bladder be particularly irritable, the mere change from a stand- ing to a recumbent posture will give pain. These symptoms do not take place in enlarged prostate, and may serve as distinctive marks between the two diseases. When the pain is very violent, there is often a sense of weight in the rectum, with a frequent de- sire to go to stool. Sometimes there are prolapsus ani, and piles. Incontinence of urine is also enu- merated as a symptom. This probably arises from the relaxation of the sphincter of the bladder, in consequence of an irritation in its general muscular coat. It may also arise from the stone being so large, as nearly to fill the whole cavity of the bladder, and thus leave no room for the accumulation of urine, which will necessarily be constantly passing off. I have assisted in the examination of a patient, who died under the latter circumstances. The urine is sometimes limpid, commonly it has a wheyey appearance, probably from the quantity of mucus it contains, and which it deposits in the form of sediment. This increased quantity of mucus is secreted, as a defence to the bladder from the irri- tation of the stone. After violent exercise, blood is mixed with the urine. Mucus, speckled with blood, is deemed an unequivocal symptom. A gravelly deposit is also common : it may be either the Uric acid precipitated in the vessel, or a gravel of the phosphates. When the complaint has proceeded to a violent 13 height, and what may be termed the latter stages have set in, the constitution will suffer from the irri- tation, the abdominal muscles take on a spasmodic action, and there will be frequent and violent ri- gors. If the stone be small and have an even surface, it may cause the patient little or no uneasiness. And whatever be the size, the pain is not constant. It returns occasionally, making what have been termed fits. These are not regular in their recurrence, and arise most probably from the bladder being more irritable at one time than at another. They have been likewise attributed to the stone resting upon the commencement of the urethra. A stone passing from the kidney will also cause a fit. Exercise will sometimes produce it. The roughness of a calculus will also be the cause of much additional pain. A boy of about 14 years old had symptoms of stone from his infancy, but of the milder kind. A few weeks before the operation, his pain became violent. Dr. Post extracted the stone ; its surface was smooth, except a portion on which some crystals had formed; these were probably of a late date, and gave rise to the increase of pain. CAUSES. These, at present, are involved in great obscurity. What circumstances give some persons a disposition to these concretions, while others remain exempt, 14 have not been satisfactorily traced. The complaint seems occasionally to be hereditary; in some cases it has been ascribed to the waters of a particular tract of country. But these explanations are unsatis- factory, in as much as their application is far from general. Any solid substance introduced into the bladder, 1 will form a nucleus for the concretion of a stone. Cheselden gives a plate of a calculus, formed on a bullet " shot through the upper and back part of the thigh into the bladder of a soldier."* I have seen a similar specimen in the Museum of the Royal Col- lege of Surgeons, London. There is said to be one of a like kind in a Museum at Philadelphia. Mr. Astley Cooper exhibits to his class, a calculus formed in the urethra of a sailor on a piece of wood which he had introduced while at sea, as a substi- tute for a bougie. In the above Museum in Lon- don, besides the specimen of bullet nucleus, Sir Wm. Blizard, in his lectures at the College, exhi- bited stones formed on bougies, on pins, on a bod- kin, a needle, a pea, and a hazel-nut. Le Dran took a calculus from a child, formed on a dossil of lint, which had slipped into the bladder from a former operation.f In the Parisian Journal, mention is made of one whose nucleus was an " ear of corn; "J and of one extracted by Dessault in the Hotel Dieu, whose nucleus was a " small apple." § And in * Cheselden's Anatomy, edit. 1722, plate 30. j- Le Dran's Operations, page 250. £ The American reader may be apprised that Indian corn is not here meant. £ Vol. ii. page 386. 15 some papers, published by the Massachusetts Medi- cal Society, in 1790, a stone is described to have formed on " two or three inches of the smooth stalk of a plant, broken off in the bladder by acci- dent."* It is also familiar to surgeons, that a sil- ver catheter, left for three or four days in the blad- der, has a calculous crust deposited on its extremity. The consideration of these facts would induce a belief that calculi were generally deposited upon a nucleus ; and in the cases where an external one was wanting, a clot of blood, a piece of hardened mu- cus, a small quantity of gravel, and a stone from the kidney, have been assigned ; they are almost al- ways found in the centres of calculi. The various ingredients which make up the che- mical composition of calculi, are found in the urine. Uric acid is a permanent ingredient, although " most abundant in sick people ;"t the degree or nature of sickness which may produce it, is not indeed traced, but it may be owing to local diseased action, as well as to general sickness. The acid phosphate of lime, the phosphate of magnesia, and phosphate of am- monia, are also constant ingredients. The oxalate of lime is also found "as it were by accident." Animal matter, that is, gelatin and albumen, are likewise always present; but " very variable in their proportions in different kinds of urine." These " afford the gluten, which holds the particles of cal- culi together." Calculi of uric acid, and of oxalate of lime, ap- pear to be the only ones formed in the kidney, with- * Page 92. f Thompson's notes on Fourerov's Chemistry, vol. jii. p. 321- 16 out a nucleus. Why this should be the situation of the spontaneous concretion of these alone, cannot be well explained; unless we suppose that uric acid, when abundant, is only mechanically diffused in the urine ; a supposition which derives support from its spontaneous subsidence after urine is discharged. If such a subsidence took place in the bladder, as the particles would be very small, they would easily be washed out in passing the water, and the complaint would remain in the stage of gravel only ; no nu- cleus being retained to give rise to a stone. If this subsidence, and consequent concretion, should take place in the tubular part of the kidney, the stone would be there wedged in, and gradually receive ad- ditional laminae, until it passed to the bladder. The urine is secreted in the bladder in a dilute state, — dilute, comparing the proportion of water and salts. This dilution is lessened by retention in the bladder.* The salts, of course, may then be more readily deposited; and the presence of a nucleus, will probably make this deposition invariable. Crys- tallization, perhaps, results from a still farther depri- vation of the aqueous parts of the urine. f There are but few data on which to ground an opinion, as to the formation of mulberry calculi. They seem to be deposited in the kidney, but on what principles I cannot offer a conjecture. By adapting the above circumstances as may be necessary, and by bearing in mind, that in some * Edin. Syst. Anat. vol. ii. p. 412. Haller's Physiol, p. 390. f Admitting that uric acid and the phosphates are deposited in the raan- aer noticed, a difference between gravel and stone may be assigned. Gra- vel is the deposition of these materials, previous to their having undergone aggregation or concretion; after this process has begun, the disease is stone 17 oases the secretion of abundant uric acid may not be constant, we may account for the different species of calculi, whether of uric acid alone ; of that mixed throughout the phosphates, alternating with them in layers, or forming a nucleus for them; or of the phosphates alone. The animal operation which yields the material, will not indeed be accounted for ; but a single step towards an ultimate explana- tion is not without its value . CURE. The first analysis of urinary calculus led to the discovery of a new acid. On the ground of this dis- covery, alkalies were used, in the expectation, that passing by the kidneys, they might become so far a component part of the urine, as to dissolve the stone. In some instances these proved beneficial; but it was impossible, that in the greater number of cases, they could remove the concretion. By referring to the table before quoted, it will be seen that 128 of 150, contained more or less of the phosphates, which, as will presently be noticed, are rather increased than lessened by the exhibition of alkalies. Mr. Abernethy, in his lectures, relates a singular fact, much connected with the present subject. Two portions of calculus were put into different vessels. Into one of these, the urine of a person taking alkali was frequently discharged; into the other, urine from a person not using any medicine. 3 18 The first portion of calculus in a short time crum- bled, the other remained firm. This experiment proves, that alkalies can enter the circulation, and pass by the kidneys ; or at least, that they can so alter the urine, as to make it capable of dissolving a stone. But in this case, the subjects of experiment were exposed to the air, an agent, which may have materially promoted the dissolution of the first. Alkalies, however, are known to have a soothing effect on the bladder. They are useful in irritation of the bladder or kidneys. By this operation, they have probably gained their reputation as cures for the stone. Mr. Home* relates two cases of reputed cure of this disease by alkalies, in one of which were found after death 20, and in the other, 14 cal- culi. The symptoms he supposed to have ceased from the confinement of these stones behind the en- larged "posterior lobe of the prostate," but it is more probable, that the bladder had been rendered insensi- ble to their presence, by the remedies employed. The formation of a cyst may also account for some cases of reputed cure. In the opinion of Mr. Brande, alkalies may often be hurtful in this disease, at least they may increase the size of the stone. The phosphates are dis- solved in urine by an excess of phosphoric acid. An alkali, by neutralizing this, may increase the de- position of these substances. This opinion every practitioner will balance in his own mind, with the propriety of exhibiting alka- lies under certain circumstances ; for circumstances exist, in which they are proper. The operation is * Philos. Trans, loc. cit. 19 sometimes unadvisable, and the painful situation of the patient may call for some assistance. In such a case, as alkalies have proved at least palliative, they certainly deserve a trial. Caustic alkali, with opium in linseed decoction, is a very useful prescription. Ef- floresced soda in pills, and soda water, are used ; but are not probably so efficacious as the former, as the carbonic acid contained in them, having a stronger affinity to the alkali than the uric acid, will retain it, and prevent the chance of a solution of the stone by its uric acid uniting with the alkali. The dose of alkali is in no case to be large. With the alkaline remedies, may be noticed lime- water. Its solvent powers are analogous to those of alkalies : how far it may prove soothing, I have no authority to determine. Messrs. Fourcroy and Vauquelin have lately re- vived attempts to dissolve a stone by injecting alka- lies into the bladder. They have found occasional success. But in addition to the objections to alkalies in general, this plan is imperfect, from the dilute state in which the medicine must be introduced, and the indisposition of the bladder to bear artificial distention. It is probable too, that the success has been very limited, or the method would now have more numerous advocates, as their experiments were instituted several years since. As the phosphate calculi are soluble in muriatic acid, this has been exhibited as a remedy. It is ad- mitted by Mr. Brande, that it possesses efficacy, so far as the phosphate materials of a calculus are con- cerned. But if the stone be made up in part of uric acid, or if its nucleus be of that substance, we only lose time in the experiment. The patient will de- 20 rive but limited benefit from a partial cure, and the operation will be as necessary after a course of acid, as before. A reference to the table will show, that uric acid is an ingredient too frequently met with, to warrant an expectation of success. Similar objections exist to the injection of this, as were noticed of alkalies. To the practical surgeon, however, it is needless to multiply proofs of the inefficacy of cures for stone.* An operation becomes in almost every case neces- sary. And if a patient's situation does not forbid, it is improper to defer it, lest the kidneys become so diseased as to render it of no avail. Old age does not appear to be an objection to ope- rating. Patients above 80 have been successfully cut, between 60 and 70 frequently, and at 60 very frequently. It is not well to operate on a very young- child, as untoward occurrences during the operation are more seriously felt The youngest child on whom I have heard of its being performed with suc- cess, was a year and nine months old. The existence of another disease in the system may forbid an operation. To add a new disturbance to a constitution in such a state, would be a great hazard of life. The other disease should be re- moved, and then the operation may be safely under- taken. If there be pain in the loins, and other symptoms of a descending calculus, it is proper to wait until * In a preceding note, a distinction was pointed out between gravel and stone. From that it will appear, that the former of these will only be known by observing the gravelly discharge. If the complaint be in this state without symptoms of stone, the exhibition of alkalies or muriatic acid may be useful. 21 these have subsided, that the additional calculus may be removed by the same operation. A discharge of blood on introducing the sound, and other symptoms of highly irritable bladder, may render it prudent to wait, until, by the exhibition of alkalies and other remedies, the excessive irritability be subdued. A slight degree of irritability is no objection to operating. SOUNDING. No single symptom of stone is sufficiently une- quivocal to warrant an operation. Nay, although the whole united may afford the highest presump- tive proof of the existence of a calculus, no surgeon is justified in operating, unless he receive the more full conviction to be obtained from sounding. Previous to introducing the sound, the urine should have been retained a few hours, that the bladder may be sufficiently distended to allow the necessary mo- tion of the instrument. The most convenient position is a recumbent one, with the head and chest elevated. The hip and knee joints are to be flexed, the knees are to remain asun- der, and the patient must allow his muscles to be as relaxed as possible. Other positions may be neces- sary, but these must be regulated by circumstances. The introduction of a sound, if there be no dis- ease, is effected without much difficulty. The canal of the urethra is to be followed; and if the point of 22 the instrument be entangled in the folds of its lining membrane, or in the orifices of the lacunas, it must be slightly withdrawn, and the attempt repeated. A large sound, in a healthy urethra, is most easily in- troduced. Some have disputed whether a sound should be passed with its convex or concave side to the abdo- men. The former requires a turn when the point reaches the membranous part of the urethra. This turn is supposed to increase very much the pain of introduction — a pain so great in some cases, that I heard a boy, who had been twice before cut, while on the table for a third operation, entreat the surgeon not to introduce the staff, as he feared it more than the incisions themselves. I have inquired of pa- tients, in whom I introduced the catheter both ways, and they found no perceptible difference. From this fact, and from finding surgeons divided in opinion, it is probable that there is no very great dif- ference between the two methods. Introducing it with the convex part to the abdomen, appears rather the easiest to the surgeon. Stricture may prevent the passage of a sound. If this be spasmodic, a gentle pressure against the ob- struction will often make it dilate. If the stricture be permanent, its cure is to be first effected. Enlargement of the prostate will change the curve pf the urethra, giving it a turn upwards. When the sound is checked at this part, a finger should be in- troduced into the rectum to raise its point. The stone is often felt immediately on the enter- ing of the sound. Sometimes it is lodged in the in- ferior posterior part of the bladder, so as to require a finger in the rectum, to elevate it until it strikes 23 the instrument. The patient's position may be va- ried. Or a catheter may be introduced in place of the sound, which, as it allows the urine to flow, will make the bladder contract so as to bring the stone in contact with it. Mr. J. Bell* is very strenuous in advising* the introduction of a finger or two into the anus, to ascertain the relative situation of parts, and the size of the stone. But I think, that a surgeon should rely with caution on information so indis- tinctly obtained. Mr. Abemethy relates in his lectures, that a pa- tient was obliged to introduce a catheter eveiy two hours for several years, to discharge his urine ; but never discovered any stone. Seven were found in his bladder after death. Dessaultf records a case, in which the operation was performed after (as the surgeon and his assist- ants thought) having felt and heard the stone by the sound. When the forceps were introduced, they could not be opened to grasp the stone. A scoop was passed in to assist the extraction, and made the noise of two hard bodies in collision ; but no stone was extracted. On examination, " no stone was found to exist ; but the bladder was found compact, cartilaginous in its circumference." — It is reported of Mr. Cheselden, " that in the course of his prac- tice, which indeed was very extensive, three patients were cut by him in whom no stones were discovered, and where a schirrous or hardened state of the blad- der had given rise to the mistake.":!; These cases * Smith's Abridgement, page 174. f Parisian Journal, vol. ii. p. 125. 4 R. Bell's Surgery, vol. iii. p. 164. Troy edit. 24 cannot render the feel of a stone in sounding a less reasonable ground for operating. It must be held as an invariable maxim, never to operate unless the stone be felt by the staff, when introduced for the operation. Cases have occurred, in which the stone has slipped between the fasciculi of the muscular coat of the bladder, and carrying with it the internal membrane, has formed a sac, se- parate from the general cavity of that viscus. Mr. Home, in the paper above quoted, states that he has frequently met with them, even two, three, or four in one bladder, and each containing a stone. Dr. Smith, in his notes on J. Bell's Surgery, mentions that he has seen one.* In Mr. Abernethy's collec- tion, I have seen such specimens. When in such a sac, a stone is not painful; and as the sac may be formed between the times of first sounding and of operating, it would be unjustifiable to hazard the pa- tient's life, for the removal of a disease which was to be no longer troublesome. These sacs have sometimes prevented the extraction of a stone after an operation for that purpose. Dr, W. Moore re- lated to me an instance of this, which occurred to the late Dr. J. Jones of this city. The nature of the case, and the existence of the sac, were made evident by examination. An operation similarly un- successful occurred lately in this place. An ex- amination of the patient could not be procured; but as it was a child, the not finding the stone arose more probably from its being in a sac, than from a disease of the bladder resembling that in Dessault's and Cheselden's cases. These are cases which ought * Paare 187 25 not to prevent us from deeming the sound a sufficient test of the propriety of an operation, as the circum- stances, from their nature, are not within the know- ledge or control of the surgeon, and as we know of no test equal in certainty to this instrument. ANATOMY OF THE PARTS CONCERNED IN THE OPERATION. In lithotomy, as in all other operations, an accu- rate acquaintance with the parts through which in- cisions are to be made, is absolutely necessary. A moderate share of anatomical knowledge has indeed sufficed for some operators. Thus Frere Jacques is said to have performed the operation, " without any direction and without any knowledge of the parts he was to cut;" his patients " were found with the blad- der cut through, guts wounded," &c. — The only means of giving a humane operator confidence, is a perfect " knowledge of the parts he is to cut." It will be readily seen, that mere description of the anatomy of these parts, will not convey an ade- quate idea of them. Dissection alone can do this. A point in the perineum, just below the bulb of the. urethra, is to be considered the centre. From this, the transversi perinei, accelerator urinse, and sphincter ani muscles proceed. The transversi pe- rinei are reckoned two ; they are given off laterally from this point, and are inserted into the tuber ischii. The accelerator urin