COLUMBIA UNIVERSITY THE LIBRARIES HEALTH SCIENCES LIBRARY L. ^ ^ CoUege of Pfjpsficians anb burgeons: itibrarp Digitized by the Internet Archive in 2010 with funding from Open Knowledge Commons http://www.archive.org/details/americanmedicalb13bige AMEBICAN" BEING A COLLECTIOJf I^ATIVE MEDICINAL PLANTS UNITED STATES, CONTAINING THEIR BOTANICAL HISTORY AND CHEMICAL ANALYSIS, AND PROPERTIES AND USES IN MEDICINE, DIET AND THE ARTS, WITH COLOURED ENGRAVINGS. BY JACOB BIGELQW, M. D. HUMFOKD PKOFKSSOR AND lECTUKER ON ^rATERTA MEBICA AND BOTANY IN HAKVAllD UNIVERSITY. yoL. I BOSTON: PUBLISHED BY CUMMINGS AND HIELIARD, AT THE BOSTON BOOKSTORE, NO. 1 CORNHIIL. TJNiyERSITK PHESS....HIM.IAHO AND METCALF. 1818. KZ-J DISTRICT OF :MASSACHUSETTS, TO WIl : District Clerk's Office. BE it remombei-ed, that on the twenty' eighth day of October, A. D, 1818, and in the forty third year ol' the Independence of the United States of America, Jacob Bigelow, M. D. of the said dis- trict, has deposited in this office the title of a book, the right whereof he claims as author, in the words follov.mg, viz. " American Medical Botany, being a collection of the native medicinal plants of the United States, containing their botanical history and chemical analysis, and properties and uses in medicine, diet and the arts, T\ith coloured engi-avings. By Jacob Bigelow, M. D. Rumford Professor and Lec- turer on Materia Medica and 13otany in Harvard University. Vol. II." In conformity to the Act of the Congress of the United States, entitled " An Act for the en- couragement of learning, by securing the copies of maps, charts and books, to the authors and propiietors of such copies, during the times therein mentioned :" and also to an act entitled, " An act supplementai-y to an act entitled, an act for the encouragement of learning, by securing the copies of maps, charts and books, to the authors and proprietors of such copies during the times therein mentioned ; and extendmg the benefits thereof to the arts of designing, engraving and etching historical and other printj. TOHVW TiAVT«; S Clerk of the District JOHN W. DAY lb, ^ of Massachusetts. \ PI .1 . Tio.h m\ ^ ^y//^i. ■^f fr/ /y/t // /// /// / J , AMEEICAN MEDICAL BOTANY. DATURA STRAMONIUM. Thorn Jipple, PLATE I. 1 HE Datura Stramonium, is a wandering an- nual plant, which follows tlie progress of culti- vation, and is rarelj found remote from the vi- cinity of dwellings. It occurs in every part of the Atlantic coast from Maine to the Floridas, and is also found in the Western States in the neighbourhood of settlements. Its favorite haunts are the borders of fields and roadsides, among rubbish and in neglected spots of I'ich ground. It emigrates with great facility, and often springs up in the ballast of ships, and in earth carried from one country to another. This circumstance in Europe has undeservedly given rise to the opinion, that it is originally an American plant. Its native country, however, is doubtful, from 18 DATURA STRAMONIUM. tlie want of autlientic descriptions of sufficient antiquity. One of the oldest satisfactory accounts of it is that of Gerarde in 1597, wlio has published a description and figure of this plant, and states that it was introduced into England by himself, from seeds received froniConstantinople. [JVb^e A.] Its common name in Europe, derived from the form of its fruit, is Thorn apple. In this country its provincial names are Apple of Perif, J)e- tWs apple^ and Jamestown weed. It is a plant of rank growth and luxuriant foliage, varying in height from one to six feet, according to the soil in which it grows. In Carolina it begins to flower in May, and in Massachusetts about the latter part of Ju- ly, and continues until the arrival of frosts. The Datura Stramonium belongs to the first order of the fifth class in the Linnsean artificial arrangement. In its natural order it is found among the Luridge of Linnseus and the Solanese of Jussieu. The following are the essential anarks which characterize the genus Datura. The corolla funnel form and plaited. The calyao tu- hulart angular and deciduous. The capsule four TaZred.— Under this genus are comprehended a number of species, a great part of which are na- tives of warm latitudes. The species Stramoni- um is distinguished from the rest by the follow- THORN APPLE. 19 ing character. Capsules thorny, erect, ovate; leaves ovate, angular, smooth. — A more particular de- scription of tlie plant is as follows. Stem erect, simple at bottom, much branched at top by repeat- ed forks, smooth or slightly pubescent, hollow in the large plants, often solid in small ones. Leaves given off from the forks of the stem, five or six inches long, acute, irregularly sinuated and tooth- ed, with large acute teeth and round sinuses, the sides of the base extending unequally down the petiole. Flowers single, axillary, on short stalks, erect or nodding. Calyx composed of one leaf, tubular, with five angles and five teeth, deciduous by breaking off from its base. Corolla funnel shaped with a long tube, five angled, its margin waved and folded, and terminating in five acumi- nate teeth. Stamens growing to the tube by their filaments, with oblong erect anthers. Germ su- perior, hairy with tlie rudiments of spines, ovate ; style as long as the stamens ; stigma obtuse^ parted at base. Capsule ovate, fleshy, covered with thorns, four valved, four celled, opening at top. Seeds numerous, reniform, black, attached to a longitudinal receptacle, which occupies the centre of each cell. At least two distinct varieties of Datura Stra-> monium are common in the United States. One 20 DATURA STRAMONIUM. of these has a green stalk and white flowers, and agrees with the figures of Sowerhj and Woodville, except that the anthers are somewhat longer and the dissepiment of the capsule thinner. The sec- ond variety, the one represented in our figure, has a dark reddish stem, minutely dotted with green ; and purple flowers striped with deep pur- ple inside. It is generally a larger plant, and its stem more universally hollow. This variety is probably the D. tatula of Linnseus, answering to the description in the Species plantarum. The distinguishing marks laid down between the two plants are not sufficient to make them distinct species. I have cultivated both together and watched them throughout their growth, without being able to detect any difference except in col- our. Their sensible and medical properties are the same. Sir James Edward Smith has lately informed me, that on consulting the herbarium of Linnseus, the original specimens of D. Stramoni- um and tatula did not appear to be more than va- rieties of the same plant. [JVofe B.] Every part of the Stramonium, when recent, has a strong, heavy, disagreeable odour, and a bitter, nauseous taste. Taken internally it proves a violent narcotic poison, affecting the mind and body in the most powerful manner. Its usual THORN APPLE. 31 consequences when swallowed in considerable quantity, are vertigo and confusion of mind, in- sensibility of the retina, occasioning dilatation of the pupil and loss of sight, tremors of the limbs and loss of the power of voluntary motion, head- ach, dryness of the throat, nausea and vomiting, anxiety and faintness, and sometimes furious de- lirium. If the amount taken be large and not speedily ejected from the stomach, the symptoms pass into convulsions or lethargic stupor, which continue till death. When not fatal, its effects, like those of other narcotics, are temporary, dis- appearing in from one to two days, and frequent- ly in a shorter period. — The remedies to be re- sorted to in cases of poison from Stramonium, are a prompt emetic, followed by a free use of vegeta- ble acids and strong coffee. Many stories have been related of the power of this and other species of Datura to produce mental alienation, without at the same time ma- terially affecting the body. [JVbfe C] These ac- counts are generally of somewhat ancient date, and not correspondent with the observations of later physicians. They were suited to those days of credulity, in which the Eoyal Society of London gravely inquired of Sir Philberto Vernatti, "Wheth- er the Indians can ^ so prepare the stupifyin.c^^ 22 DATURA STRAMONIUM. herb Datura, tliat they make it lie several days, months, or years, according as they will have it, in a man's body ; and at the end kill him with- out missing half an hour's time ?" Like opium and like other powerful medi- cines, this plant, when taken in small quantity, and under suitable regulations, proves a remedy of importance, and a useful agent in the hands of physicians. In common with some other narco- tics, it seems first to have been introduced freely into practice by Baron Storck of Vienna, as a rem- edy in Mania, Epilepsy, Convulsions, ^c. Many subsequent physicians have given testimony to its efficacy in certain forms of these disorders, yet the instances of its failure have doubtless been more frequent than those of its success. In Murray's Apparatus Medicaminum may be found a sum- mary of the reports of many medical men, who have tried it with various success in the diseases in question, as well as in others. Dr. CuUen has no doubt that it may be a remedy in certain ca- ses of mania and epilepsy ; but doubts if any per- son has learned to distinguish the cases to which it is properly adapted. Dr. Fisher, President of the Massachusetts Medical Society, has published in theu* communi- cations some remarks on the employment of Stra- THORN APPLE. 23 inonium in epilepsy. He divides the cases of that disease into tliree kinds ; tliose of which the fits return daily ; those in which they recur at regular periods, as monthly, or give warning of their approach by previous symptoms ; lastly, those in which they do not observe any regular period, and do not give any warning of their ap- proach. In the two first kinds he asserts, that all the cases which came under his care, and which were not very few, had been cured by Stramoni- um. In those of the third kind he found it of no benefit whatever. Dr. Archer of Maryland has formed distinc- tions nearly similar in the application of Stramo- nium to epilepsy. In a case of Tic doloureux of loner standing I found the extract, taken in as large doses as the stomach would bear, to afford decided relief. Sev- eral practitioners have spoken to me of its effica- cy in this formidable disease. It should be ta- ken in large doses, and the system kept for some time under its influence. Within a few years, the thorn apple has at- tracted much notice, both in Europe and in this country, as an efficacious palliative in Asthma and some other affections of the lungs, when used by smoking, in the same manner as tobacco. 24f DATURA STRAMONIUM. The practice was first suggested by the employ- ment of another species, the Datura ferooo^ for similar complaints, in the East Indies. An En- glish gentleman, having exhausted the stock with which he had been supplied of the oriental plant, was advised by Dr. Sims to have recourse to the common Stramonium as a substitute ; and upon trial, experienced the same benefit as he had done from the former species. This instance of suc- cess led to further trials, and in a short time sev- eral publications appeared, containing cases of great relief afforded by smoking this plant in the paroxysms of Asthma. Many individuals, of dif- ferent ages, habits, and constitutions, had used it with the effect of producing immediate relief, and of terminating the paroxysm in a short time. The efiicacy however of this medicine was called in question by Dr. Bree, a physician well known by his elaborate treatise on Asthma, who publish- ed in the Medical and Physical Journal a letter, containing the result of a great number of unsuc- cessful trials of Stramonium in asthmatic cases. It may be doubted whether any other physician has been so unfortunate in its use as Dr. Bree, since he affirms tliat not one case of those under his care was benefitted by it. Certain it is, that in this country the thorn apple is employed with THOBN APPLE. gg very frequent success by asthmatic patients, and It would not be diffictdt to designate a dozen indi- viduals in Boston and its vicinity, who are in the habit of employing it with unfailing relief in the paroxysms of tliis distressing complaint. The ca- ses, which it is fitted to reliere, are those of pure spasmodic asthma, in which it doubtless acts by its sedative and antispasmodic effects. In those depending upon effusion of serum in the lungs, or upon the presence of exciting causes in the' first passages, or elsewhere, requiring to be removed ; it must not be expected that remedies of th,s class can afford benefit. In several cases of plethoric and intemperate people, I have tound It fad altogether, and venesection after- wards to give speedy relief. The part of the plant, which I have employed for smoking, is the leaf prepared in the same way as tobacco. The root, which has commonly been the part used, is more woody and fibrous, and pos- sesses less of the juices of the plant, than its more pulpy and succulent parts. The root also, bemg strictly annual, has no opportunity to accu- mulate the virtues of the plant, beyond any other part. In the seventh volume of the Medico-Chirur- gical Transactions, for 1816, is a paper on tlse 4 S6 DATURA STRAMONIUM. properties of the Stramonium by Dr. Marcet of London, Physician to Guy's Hospital. As the result of his experience, it appeared that this medicine taken internally had relieved acute pains of various kinds more effectually than any other narcotic substance. Its usual effects under his observation, when administered in appropriate doses, in chronic diseases attended with acute pain; were, to lessen powerfully and almost imme- diately sensibility and pain ; to occasion a sort of nervous shock, which is frequently attended with a momentary affection of the head and eyes, with a degree of nausea, and with phenomena re- sembling those produced by intoxication ; to ex- cite in many instances nervous sensations, which are referred to the oesophagus or bronchise or fau- ces, and which sometimes amount to a sense like suffocation ; to have rather a relaxing, than an astringent effect on the bowels ; to have no mark- ed influence on the pulse, except in a few instan- ces to seem to render it slower ; to produce but a transitory and inconsiderable dilatation of the pupil, and to have but little immediate tendency to produce sleep, except from the state of com- parative serenity and ease, which follows the pre- ceding symptoms.' — In some instances its bene- ficial effects were obtained without the ]>atient experiencing any of the uneasy sensations above mentioned. THORN APPLE. gi^ The cases in which Dr. Marcet employed the Stramonium, with their results, appear in the fol- lowing summary. In four cases of Sciatica, decide ed benefit was obtained. The efficacy of the med- icine was still more strongly marked in two cases of sciatica combined with syphilitic pains. It failed in two instances of diseased hip joint. It produced considerable relief of pain in a case of supposed disease of the spine, followed hj para» plegia I and likewise in one of cancer of the breast. It allayed materially the pain occasioned hy an acute uterine disease. It was of great and repeated utility in a case of Tie doloureux, its utlL ity in a second case of the same description was Tery doubtful, and in a third it entirely failed. There are some authorities for the success of Stramonium in Chorea. Professor Chapman of Philadelphia has found it of use in dysmenorrhea, also with or without mercury in syphilitic and scrophulous ulcers of ill condition. The external use of Stramonium is of mucli older date than its internal exhibition. Gerarde in his Herbal, published in 1597, says, "The iuyce of Thorne apples, boiled with hog's grease to the forme of an unguent or salye, cureth ail in. flammations whatsoever, all manner of burnings or Bcaldings, and that in yery short time, as mv^ 28 DATURA STRAMONIUM. self liaye found by my dayly practise, to my great credit and profit." Others, since the time of Ge- rarde, have used this preparation, if not with the same gratifying success, at least with some bene- fit as an anodyne, sedative application. It miti- gates the pain in burns and inflammatory tumors, and promotes the cure of certain cutaneous erup- tions. In some irritable ulcers with thickened edges and a sanious discharge^ I have found it re- markably efficacious in changing the condition and promoting the granulations and cicatrization. In painful hemorrhoidal tumors the ointment of Stramonium with the ointment of acetate of lead gives, in many cases, very prompt and satisfacto- ry relief, being in this respect inferior to no ap- plication, with which I have been acquainted. Applied topically to the eye, the preparations of Stramonium diminish the sensibility of the re- tina, and relax the iris. From this effect it is employed by many surgeons to dilate the pupil, as preparatory to the operation for cataract. The virtues of Stramonium appear to be seat- ed in an extractive principle, which dissolves in water and alcohol, but most readily in the for- mer. It is copiously precipitated from the infu- sion by muriate of tin. With sulphate of iron it gives a deep green colour, and with gelatin suf- THORN APPLE. ^9 fers no change. Water distilled from the plant has the sensible qualities in a slight degree, but does not seem to possess the medicinal po>yers of the plant. Dr. S. Cooper, in a valuable disserta- tion on this plant, sajs, that an ounce of the dis- tilled water was taken into the stomach with little or no effect. The same gentleman states, that upon evaporating the infusion of Stramonium, he observed a large number of minute crystals, re- sembling particles of nitre. Thinking it possible that these might be something analogous to the crystals, said to be obtained by Derosne from opi- um, and by him denominated the narcotic princi- ple, I repeated the experiment by carefully evap- orating separate decoctions of the green and dri- ed leaves. No crystals however were discovera- ble at any stage of the process, either to the touch, or to the eye assisted by a strong magni- fier. The forms in which the Stramonium is prepar- ed for use are the powder, the inspissated juice, the extract, the tincture and the ointment. The powder should be made as soon as the plant is dry, and kept in close stojjped bottles. — The in- spissated juice is made by compressing the bruis- ed leaves in a strong bag, until the juice is forced out. This is to be evaporated in flat vessels at 30 DATURA STRAMONIUM. the heat of boiling salt water to the thickness of honey ; it is then suffered to cool, put tip in glaz- ed vessels and moistened with alcohol. The ecC' tract is prepared by immersing a pound of the leaves in three gallons of water and boiling down to one. The decoction should then be strained and stand six hours to settle, after which it may be drawn off and evaporated to the proper consis- tence. When the seeds are used, the decoction should stand a longer time to separate the oil with which the cotyledons abound, before evaporation. A larger amount of extract may be obtained by boiling the portion, which has been used, a se- cond time in a smaller quantity of water, and mixing the two decoctions before evaporation. For the tincture one ounce of the dried leaves is to be digested for a week in eight ounces of proof spirit, and filtrated through paper. In making the ointment, a pound of the fresh leaves may be simmered in three pounds of hog's lard until the leaves become crisp. It is then to be strained? and cooled gradually. The period for gathering the leaves is from the time the plant begins to flower, until the ar- rival of frost. As the preparations of Stramonium are liable to vary in strength according to the circumstances ^ THORN APPLE. 31 under which they are made, it is always prudent to begin with the smallest dose, and repeat it about three times a day, increasing each dose un- til the effects begin to appear in the stomach or head. The commencing doses of the Stramonium, when properly prepared, are as follows. Of the powdered leaves 1 grain, powdered seeds |- a grain, inspissated juice or extract 1 grain, extract of the seeds from ^ to j- grain, tincture from 15 to 20 drops. BOTANICAL REFERENCES. Datura Stramonium, Linn^us Sp, pi. Fl, Suec. 185 «^c.— ^^ Gronovius Fl. Virg. 23. — GEdek. Fl. Danica 436. — Black- WELi. t. 313. — Gmeiin Iter i. 43. — Poliich. Palatin. 224. — HoFFMAiSTV Germ. 77. — Roth Fl. Germ. i. 92 Sfc. — WooDvrLLE t. 124, — Curtis Lond. vi. t. 17. — Smith Fl. Brit. 254. — Engl. Bot. t. 1288. — ^PuRSH Amer. 141.— Ei^iott Carol, i. 275.— Stramonium foliis angulosis &c. Hailer Helv. 586. Nuci metel- Ix congener planta, Camerarius Epitome 276. — Solanum foeti- da porno spinoso, oblongo, &c. BAUHiN^iw. 168. — Sti'amonium spinosum, Gerarbe Herbal 348. MEDICAL REFERENCES. Storck de Stramonio Sfc. — Lindenstolpe devenenis, 531.— Sauvages JVosoL 2. 430. — Gredikg in Liidwigs Adversaria i. 345. — Murray App.Med.i.670. — Cvjj^n Mat. Med. i'l. 281. — Fowler in Med. Comment, y. 161. — Odhelius cii. m J^/ei. Com- ment v. 161 i- — Papin" in Phil. Trans, abr. vi. 53. — Rush inFkilad. S2 iiATURA STRAMONIUM. Trans, i. 384. — Sclioepf. 24. — Wedenberg in Med. Comment iii.l8. — ^Beverly, Hist. Virg.y. 121. — Medical and Physical Journal, vol. xxv. & xxvi. in various places. Cooper in CaldiveWs Theses, vol. i. — Earto^, Coll. Mat. Med. 46. — Chapman in edit, Murray 146. — Thatcher, Disp, 205. — Marcet Medico-Chi-^ rur. Trans, vir. PLATE I. Fig. 1, »i branch of Datura Stramoniumf the purple variety f with leaves and fiowers. Fig. 2. Stamens and style. Fig. 3. Transverse section of the pericarp, shewing the cellSf re- ceptacles and seeds. J-u^.J/. (^"L/i-a/cKfia^m yi^^y^^/c'^^ ^^^ ^^^ EUPATOEIUM PEBFOLIATUM. Thorough wort PLJITE 11. ± HE peculiar form and arrangement of the leaves in this plant render it very easy of distinc- tion at sight by the most inexperienced botanist. It flowers from midsummer to September, and is found in all latitudes from Nova Scotia to Florida. It inhabits meadows and boggy soils, growing most frequently in bunches, the stems being con- nected by horizontal roots. Its common names are Thorough tvort, Thorough wacc^ Cross wort, Bone set, ^c. The genus Eupatorium, belonging to the first order of the class Syngenesia or Compound flow- ers, and to the order Corymbifer^e of Jussieu, is characterized by its naked receptacle, its down simple or rough, its calya^ ohiong and imbricate^ 5 34 EUPATORUM PERFOLIATUM, its style longer than the corolla, and cloven half way down. The species perfoliatum, exclusively an inhabitant of America, is abundantly distin- guished from the rest, by the peculiar form of its leaves, indicated in its name. Michaux has alter- ed the specific name to connatum I think injudi- ciously. The stems of this plant are erect, round, hairy branched at top only. The leaves, which are per- forated by the stem, are rather perfoliate than connate, since thev have not the character of two leaves joined together, but of one entire leaf, hav- ing its four principal veins proceeding at right an- gles from the four quarters of the stem, two of them being situated in the place of the supposed junction. The upper leaves however are gener- ally divided into pairs. The main leaves are acuminate, decreasing gradually in breadth from the stem, where they are widest, to the extremities. They are serrated, wrinkled, pale underneath, and hairy, especially on the veins. Flowers in corymbs with hairy peduncles. Calyx cylindrical, imbri- cate, the scales lanceolate, acute, hairy. Each ca- lyx contains about twelve or fifteen florets, which are tubular, with fine spreading segments, and sur- rounded with a rough down. The stamens in each consist of five soft filaments, with blackish anthers THOROUGH WORT. 35 united with a tube. Style filiform, divided into two branches, which project above the flower. Seeds oblong on a naked receptacle. Every part of the Eupatorium has an intense- ly bitter taste, combined with a flavour peculiar to the plant, but without astringency or acrimony. The leaves and flowers abound in a bitter extrac- tive matter, in which the important qualities of the plant seem to reside. I find this principle to be alike soluble in water and alcohol, imparting its sensible qualities to both, and neither solution be- ing rendered turbid, at least for some time, by the addition of the other solvent. It forms copious pre- cipitates withmany of the metallic salts, such as mu- riate of tin, nitrate of mercury, nitrate of silver, and acetate of lead. Of the mineral acids, the sulphu- ric and muriatic form slight precipitates with the aqueous decoction ; the oxymuriatic, a more copi- ous one ; the nitric, in my experiments, gave no precipitate, but changed the colour to a red. In the alcoholic solution the oxymuriatic alone form- ed an immediate precipitate. Tannin exists very sparingly in this plant. A solution of isinglass produced a slight precipitate from the tincture, and a hardly perceptible turbidness in separate decoctions of the leaves and flowers. Sulphate of iron gave a dark green precipitate, which par- 36 ETJPATORIUM PERFOLIATUM. tially subsided in a short time. — ^In distillation, water came over very slightly affected with the sensible qualities of the plant, and not alterable by sulphate of iron, A dissertation of merit on this plant was pub- lished a few years since by Dr. Anderson of New York, in which he gives the details of numerous and elaborate chemical trials, made by him on dif- ferent parts of the plant. He concludes, among other things, from his experiments, that the ac- tive properties of the plant reside in greatest quantity in the leaves, and that its virtues are readily obtained by means of a simple decoction. The medical powers of Eupatorium are such as its sensible properties would seem to indicate, those of a tonic stimulant. Given in moderate quantities, either in substance or in cold infusion or decoction, it promotes digestion, strengthens the viscera, and restores tone to the system. Like other vegetable bitters, if given in large quantities, especially in warm infusion or decoction, it proves emetic, sudorific, and aperient. Even in cold infusion it tends to bring on diaphoresis. This plant has been long in use in different parts of the United States, for the same purposes for which the Peruvian bark. Gentian, Chamomile, ^'c. are employed. It has been found competent THOROUGH WORT. 37 to the cure of intermittent fevers by yarioiis prac- titioners in the middle and southern states. Dr. Anderson has detailed six cases of intermittents, quotidian, tertian, and quartan, out of a large number which had been successfully treated with- in his own observation by the Eupatorium both in substance and decoction. In these cases the cures were certainly expeditious, and took place at as early a period as could have been expected from arsenic or the Peruvian bark. Dr. A. cites the experience of several distinguished practi- tioners, particularly Dr. Hosack of Xew York and the late Dr. Barton of Philadelphia, in con- firmation of his own, to shew that the Eupatorium is an efficacious remedy in the treatment of va- rious febrile disorders, also of many cutaneous affections, and diseases of general debility. I have prescribed an infusion of the Euj)ato- rium in various instances to patients in the low stages of fever, where it has appeared instrumen- tal in supporting the strength and promoting a moisture of the skin, without materially increas- ing the heat of the bod} . I have also found the cold infusion or decqction a serviceable tonic in loss of appetite and other symptoms of dyspepsia, as well as in general debility of the system. S8 EUPATORIUM PERFOLIATUM. The warm infusion is a convenient substitute for that of chamomile flowers in facilitating the operation of an emetic. When employed as a tonic, this plant may be taken in powder in doses of twenty or thirty grains, or a teacup full may be used of the infu- sion, rendered moderately bitter. When intend- ed to act as an emetic, a strong decoction may be made from an ounce of the plant in a quart of water, boiled to a pint, BOTANICAL REFERENCES. Eupatorium perfoliatum, Linst-eus, Sp. pi. — ^Aitoiv, Hort, Kew. iii. 160. — Wixidenow, Sp, pi. iii. 1761. — Gronovius, Virg. 119. — CoiDEN-, JVbrefior. 181. — Stokes, iv. 171. — Pursh, ii. 516. — Eupatorium connatum, Michatjx, Fl. Amer. ii. 99.— Eupatorium Virginianum, &c. — Pi.UKE]>rET, t. 87. f. 6.< — Raius, suppl. 189. — Moris ON, hist. iii. 97. MEDICAL REFERENCES. ScHOEPF 121. — GuTHEiE in Jlnnal. Med. iii. 403. — Bart. Coll. 28. — Med. and Phtjs. JbwniaZ.— Thacher Disp, 217. — An- derson, Inaugural Thesis, PLATE II. Fig. 1. Eupatorium perfoliatum. Fig. 2. A Jiower magnified. Fig. S. Jl fioret magnified. Fig. 4. Tii&e of anthers with the style running through. fl'f//f'^/''f PHYTOLACCA DECANDRA. Poke, PLATE III, JbROM tlie testimony of different writers it appearSjthattlie Phytolacca decandra is an inhab- itant not only of North America, but likewise of the south of Europe from Portugal to Greece, and also of the Barbary states in Africa. Its origin is probably American, since I find that it was so considered in the time of Parkinson, who in his Theatrum Botanicum, published in 1640, de- nominates it " Solanum magnum Yirginianum ru- brum." This is one of the oldest accounts I find of it. Plukenet conjectures it may be the Cuechi- liz tomatl of Hernandez, but the description, like most otliers of that loose and superficial writer, are more promotive of obscurity than of knowledge, and it is not easy to draw from it any satisfactory evidence as to its Mexican origin. [JS^ote D.] 40 PHYTOLACCA DEC AND RA. In the autumnal months no plant among us is more remarkable than the Phytolacca for its large size, and the fine coloui' of its clusters of berries. Its most general appellation is Foke, an abbrevia- tion, perhaps, of Pocaii, the name by which it was known in Virginia a century ago. In Xew Eng- land it is more frequently called Garget, Cocum^ Jalap and Pigeon berries. Jussieu has arranged this genus among his Jltriplices, and Linnseus with the Oleracem. The number of its stems and styles, place it in the class Becandria and order Becagynia. Its generic character consists in having no calyx, a corolla of jive petals, and its berries superior with ten cells and ten seeds. The species decandra is the only one which strictly agrees with its class and order, and is known by having ovate leaves, acute at both ends, and itsjiowers with ten stamens and styles. The root of this plant is of large size, frequent- ly exceeding a man's leg in thickness, and is usu- ally divided into two or three principal branches. Its substance is fleshy and fibrous, and easily cut or broken. Internally it is distinctl)^ marked with concentric rings of considerable thickness, while its outer surface is covered Avith a very thin brown- ish bark, which seems to be little more than a cu- I'OKE* 41 tide. The stalks, which are annual, frequently grow to the height of six, and even nine feet. They are round, smooth, and very much branch- ed. When young, their usual colour is green, but in most plants, after the berries have ripened, they are of a fine purple. The leaves are scatter- ed, petioled, ovate-oblong, smooth on both sides, ribbed underneath, entire, acute. The flowers grow on long pedunculated racemes opposite to leaves. Peduncles nearly smooth, angular, as- cending. Pedicels divaricated, sometimes branch- ed, green, white, or purple, furnished with a small linear bracte at base, and two others in the mid- dle. Calyx none. Corolla resembling a calyx, whitish, consisting of five round-ovate, concave, incurving petals. Stamens ten, rather shorter than the petals, with white, roundish, two lobed anthers. Germ greenish, round, depressed, ten furrowed. Styles ten, short, recurved. The flow- ers are succeeded by long clusters of dark purple berries, almost black, depressed or flattened, and marked with ten furrows on the sides. The dried root is light coloured and spongy, with a mild and somewhat sweetish taste. A part of it is soluble both in water and alcohol, and nei- ther of these substances renders turbid the solu- tion in the other, unless the solution has been in- 6 4S PHYTOLACCA DECANDRA. spissatedby long boiling. The soluble portion ap- pears neither resinous nor mucous. It approach- es most nearly to extractive, but has characters somewhat peculiar to itself. A decoction of the root procured by boiling for ten minutes in dis- tilled water, exhibited after filtration the follow- ing results. It was transparent, nearly colourless, and did not alter litmus. It gave no precipitate with the sulphuric, nitric, muriatic, oxy muriatic, and acetous acids. It gave no precipitate with the sulphate of iron, but formed a copious one with the nitrates of mercury and silver, and the ace- tate of lead. Muriate of tin produced no effect at first, but after standing, a liglit precipitate took place. Pearl ash, lime water, and muriate of ba- rytes rendered the solution turbid. Acetate of barytes occasioned no change. Oxymuriate of lime formed an immediate precipitate. The cold infusion exhibited nearly the same results as the decoction. The alcoholic solution underwent no change from muriate of tin, but threw down a dense precipitate with nitrate of mercury. From the above experiments it appears, that the soluble principle of the Phytolacca differs from common vegetable extractive, as defined by the chemists, in several respects, particularly in POKE. not being thrown down by the oxymnriatic or other mineral acids, and in being but partially affected by muriate of tin. In the Jlnnales de Cliimie, vol. Ixxii, is a me- moir on the Chemical properties of the Phyto- lacca decandra by M. Braconnot. His experi- ments indicate the presence of an unusual quan- tity of vegetable alkali in this plant. He found that the ashes, procured by incinerating the stalks, afforded nearly 67 per cent, of dried alkaline car- bonate, and 43 per cent, of pure caustic potash^ This alkali in the plant is neutralized by an acid having considerable affinity to tlie malic, but with a few shades of difference. With lime and lead malic acid forms flocculent precipitates, very easily soluble in distilled vinegar, but those with the phytolaccic acid are insoluble. M. Hracon- not thinks this acid may probably be a mean be- tween the malic and oxalic acids, or an oxygeniz- ed malic acid. The same memoir contains an examination of the colouring matter in the berries of the Phyto- lacca. The juice of these berries is of a very fine, bright purple colour, but this colour is ex- tremely fugacious and disappears in a short time from cloth or pnper that has been tinged with it» A few drops of lime water added to this purple 44? PHYTOLACCA DEC AND RA. juice change it to a yellow colour, but the small- est quantity of acid is sufficient to restore its pur- ple hue. Exposure to the air or large dilu- tions is sufficient to restore the original purple. M, Braconnot considers the yellow liquor pro- duced by the juice of these berries and lime wa- ter as one of the most delicate tests of tlie pres- ence of acid. Into two glasses he put equal quantities of the juice made yellow and of an in- fusion of litmus of equal depth of colour. More than sixty drops of a very weak acid were required to redden the infusion of litmus, but less than fif- teen restored the purple colour of the Phytolacca. Hence it follows, that the yellow liquor is four times as sensible to the presence of acid, as the infusion of litmus. It however requires to be us- ed immediately after it is prepared, since a few hours cause a spontaneous change in it, which be- gins with a precipitate, and ends with a depriva- tion of colour. The effects produced on this purple colour hy other reagents were as follows. Pure alkalis gave it a yellow colour. Alkaline subcarbonates a vio- let, that fades and becomes yellow by standing. Weak acids no perceptible change. Dilute oxy- muriatic acid a complete deprivation of colour with white fiocculi. Alum nothing at first, but POKE. 40 after some days, a very liglit red precipitate. Mu- riate of lime no change. Muriate of tin a red se- diment inclining to lilac, leaving the fluid colour- less. Mtrate of lead a precipitate of the colour of wine lees. Super oxided sulphate of iron, a dirty violet. Many of the above experiments I have repeat- ed, and added others. The yellow colour produc- ed by the alkalis borders on green. Pure stron- tian produces the same change as potash and lime. Pure barytes wholly discharges the colour on standing a short time. Acetate of lead forms a scarlet precipitate, leaving the liquid nearly col- ourless. The purple colour that tinges the cuticle of the stalks of the Phytolacca is stated in the above memoir, to be of the same nature as that in the berries, and to afford the same results. The taste of the berries is sweetish and nause- ous, leaving behind a very slight sense of acrimo- ny. M. Braconnot, found tliat at a moderate tem- perature, the juice underwent the vinous fermen- tation, and yielded alcohol by distillation. Dr. Shultz procured from half a bushel of the berries six pints of spirit sufficiently strong to take fire and burn with readiness. 46 PHYTOLACCA DECANDRA. In its medicinal properties the root of the Phy- tohicca decandra approaches nearer to ipecac- uanha than any American vegetable, I have hith- erto examined. From abundant experience, the result of many trials made in Dispensary practice, I am satisfied that, when properly prepared, it operates in the same doses and with the same cer- tainty, as the South American emetic. Ten grains of the powder will rarely remain on the stomach, and twenty or thirty produce a powerful operation, by emesis and generally by catharsis. In its mode of operation, this medicine has some peculiarities, a part of which are favorable, others disadvanta- geous. Its advantages are, that it operates with ease, and seldom occasions pain or cramp. Its dis- advantages are, 1. That it is slow in its effects, frequently not beginning to operate until an hour, and sometimes two hours after it is taken, 2, That it continues to operate for a greater length of time than is usual for emetics, although as far as I have been able to observe, it is readily checked by an opiate. Tliese disadvantages how- ever are not constant. I have repeatedly known it commence operating in fifteen minutes, and cease after four or five ejections. The represen- tations of patients as to any unpleasant feelings under its effects, are not greater than we should POKE, 4^ naturally expect, when it is recollected, tliat no emetic is altogether comfortable in its operation. Dr. Fisher of Beverly* informs me that whenever he has used the Phytolacca, it has performed its duty as an emetic perfectly well, and that in one patient, a female of irritable stomach, in whom previous emetics had always excited severe spasms, ten grains of the Phytolacca operated ef- fectually, and no spasm followed. I have sometimes observed slight narcotic symptoms during the operation of Phytolacca, particularly vertigo. But others have not always met with this symptom. Br. George Hayward of this town, who has had much experience with this medicine, the results of which were communicat- ed to the Linn^an society, and afterwards publish- ed in the New Eugland Journal, October 1817, states that in doses of a scruple, he never notic- ed any dizziness, or stupor from it, although he had always been particular in his inquiries to know if any such symptoms took place. The above dose was administered by him in nearly thirty cases, in all of which, except in one case, it operated as an emetic and cathartic, usually three or four times, tlioroughly, though not severely, generally commencing its operation on the stom- * Letter dated Novemberj 1815. 48 PHYTOLACCA DECANDRA. ach in an lioui% and rarely continuing longer than four. He found it to excite little or no nausea preyious to its operation, and though it made a powerful impression on the system, it never pro- duced any disagreeable or unusual symptoms. Dr. Hayward also made trial of the powder of the leaves, which he found to possess the same properties with that of the root, hut to be less ef- fectual and less certain in its operation. He al- so prepared a tincture^ decoction, and wine of the root ; hut all these were inferior to the medicine in substance, being less certain in their effect, and sometimes giving rise to troublesome symptoms. Dr. Shultz of Pennsylvania, author of an in- augural dissertation on the Phytolacca decandra, gave the expressed juice of the leaves, berries, and roots, in considerable quantity to animals. It operated by emesis and catharsis, attended with drowsiness. The j nice of the root was most active. He also gave to a dog two ounces of the spiritous liquor distilled from the berries. It occasioned nausea and drowsiness, with slight spasmodic mo- tions, but no vomiting. In the same dissertation, Dr. Shultz refers to several instances of persons who had incautiously eaten large quantities of the root through mistake. Its effects were violent vomiting and pui^ging. POKE. 49 prostration of strength, and in some instances convulsions. The Phytolacca has had some reputation in the treatment of rheumatism, Dr, Griffits, for- merly a professor in the University of Pennsylva- nia, found it of great use in Syphilitic rheumatism. Dr. Hay ward however states, that he derived no advantage from its employment in rheumatic af- fections. The young shoots of this vegetable are desti- tute of medicinal qualities, and are eaten in the spring in some parts of the United States, as sub- stitutes for asparagus. At this time the succus proprius or returning juice of the plant is not yet formed by exposure of the sap to the atmospheric air, in the leaves. The ripe berries are less nox- ious than the green, and are devoured by several species of birds. In Portugal and in France they were formerly employed to improve the colour of red wines, until the interference of government became necessary to put a stop to the prac- tice. The external application of Phytolacca has been found useful in a variety of cases, by its ac- tion as a local stimulant. The ointment and ex- tract have commonly been employed for this pur- pose. These preparations usually excite a sense of 7 50 PHYTOLACCA DECANDRA. heat and smarting on being first applied. I have cured cases of psora with the ointment, and Dr. Hayward states, that he found it successful in cas- es where sulphur had failed. A case of tinia capitis of twelve years' standing, which had re- sisted various kinds of treatment, was also cured hj this application. The Phytolacca is one of those vegetables which has had its temporary reputation for the cure of cancer. For this purpose it has been re- sorted to in various parts of the world, and many m^en of science have been convicts to its efficacy? among whom were Dr. Colden and Dr. Franklin of our country. [JSTote E.] But like other vegetable specifics for cancer, it owes its character to an im- perfect discrimination of that disease, and a mis- application of the name. All that can be strictly inferred from tbe various accounts we have had on this subject, is, that the plant has often proved useful in malignant ulcers by its stimulating and almost escharotic eifects, frequently producing an eschar, and thus altering the condition of the ul- cerated surface. For internal use no preparation of the Phyto- lacca is to be preferred to the powder, of which from ten to fifteen grains is often a sufficient emetic. DRAGON ROOT. 51 The root should he dug late in autumn or dur- ing the winter. It should he cut in transverse slices and dried. After heing pulverized, it should he kept in close stopped phials. The stock should he annually renewed, as its activity is impaired by age. BOTANICAL REFERENCES. Phytolacca decandra, Linn^us, sp.pl. — Aiton, JETor^ TCew. ii» 122. — Botanical Magaaine, t. 931. — Michatjx, Fl. Amer. i. 2r8„ PuBSH. i. 324. — Phytolacca vulgaris, Diulenius, Hort. EUK t. 239. — P. Americana — Boerhaave, Ho7't, Lug. ii. 70. — Solari- um racemosum Americanum, Raius, Hist. 662. — Plukenetj, Phyt, t. 225. /. 3. — Solanum magnum Virginianum rubrum^ Paekinson, Theatrum, 347. — Blitura Americanum^ Muntibt- Gius, Phyt. ciir. t. 212. MEDICAL REFERENCES. Murray, appar. med. iv. 335.^ — Kaim, travels in JV. Jlmer. i. 197. — Graffenreid, Mem. Berne, iii. 185. — Schcepf. 71.— ~ Browne, Hist. Jamaica, 232. — Jimoen. Acad. iv. — Mlller, Dict-^ under the name. — Sprogex. Biss. dr. ven. 24. — Beckman, com- ment. Gotting, 1779, 74.-- Allioni, Flor. Fed. ii. 132.— Frank- MN, works, vol. i. — Cutler, Mem. Amer. Acad. i. 447. — RusHj. i. 259. — Thacher, Bisp. 300. — Shuitz, Inaugural thesis.-^ Hayward, JV. Engl. Journal, vi. PLATE III. Fig. 1. Phytolacca decandra infioiver and infrvAL Fig. 2, Section (^ a berry. AiaUM TRIPHYLLUM. Dragon root. PLATE IV. It appears, that both !N"orth and South Amer- ica give rise to this species of Arum, which is so versatile in its constitution as to bear the winters of Canada, and the perpetual summer of Brazil, In its structure it is one of our most singular veg- etables, and in colour one of the most variable. It grows in swamps and damp shady woods, and is universally known among us by the names of Dra- gon root and Indian turnij). The class to which the family of Arums be- long, is rendered somewhat obscure by the varia- tion of the species. Most botanists have placed them in the class Monaecia, others in Polyandria, The species under consideration is undoubtedly Polygamous. In natural arrangements, the Arums Fu.jt: /f///// /y//f//f///f//ff 54) ARUM TRIPHYLLUM. gether. In some it is wholly green, in otliera dark purple or black. In most it is variegated, as in our figuj-e, with pale greenish stripes on a dark ground. The spadix is much shorter tlian the spathe, club shaped, rounded at the end, green, purple, black, or variegated, suddenly con- tracted into a narrow neck at base, and surround- ed below by the stamens or germs. In the bar- ren plants, its base is covered with conical, flesby filaments, bearing from two to four circular an- thers each. In the fertile plants, it is invested with roundish crowded germs, each tipt with a stigma. Plants which are perfectly moncecious, and which are the least common, have stamens below the germs. There are also frequently found irregular, reniform substances, much larger than the anthers, of which they seem to be a dis- ease. The upper part of the spadix withers with the spathe, while the germs grow into a large compact buncli of shining scarlet berries. Every part of the Arum, and especially the root, is violently acrid, and almost caustic. Ap- plied to the tongue or to any secreting surface, it produces an effect like that of Cayenne pepper, but far more powerful, so much so, as to leave a permanent soreness of many hours' continuance. Of this any one may become satisfied by a simple DRAGON ROOT. 55 application of the root to his mouth. Its action does not readily extend through the cuticle, since the bruised root may be worn upon the external skin until it becomes dry, without occasioning pain or rubefaction. The acrid property, which resides in tliis and other species of Arum, appears to depend upon a distinct vegetable principle in Chemistry, at present but little understood. It is extremely volatile, and disappears almost entirely by heat, drying, or simple exposure to the air. I have en- deavoured, with but partial success, to obtain it in a separate state, or in any perceptible combina- tion. The following were some of the methods by which it was attempted. Portions of the fresh contused root were sepa- rately digested in water, in proof spirit, in alcohol, in ether, in olive oil and in vinegar. The infu- sions were tasted at different periods, but none of them had acquiretl the least acrimony from the plant. The expressed juice of the root upon standing one minute had lost all its pungency. A quantity of the bruised root was placed in a retort and covered with water. Heat was gradu- ally applied, until a fluid began to collect in the receiver. This fluid had the peculiar odour of 56 ARUM TRIPHYLLUM, the root, but was wholly without acrimony. The same experiment was repeated with alcohol, and vinegar, and afforded similar results. In every case the liquid remaining in the retort was also without pungency. Some slices of the root were digested in proof spirit in a close stopped phial. The portions of root retained their acrimony at the end of soma weeks, but had imparted none to the spirit. At the end of two years, the root was examined and found destitute of acrimony, as were also the whole contents of the phial. Suspecting that the acrid principle of this plant must escape in form of gas during the pro- cesses which have been mentioned, the fol- lowing experiment was made. A quantity of the bruised root and stalks were placed in a vessel of water. A glass receiver was filled with water and inverted over them, and sufficient heat applied to raise the water nearly to the boiling point. From the beginning of the process, bubbles of air con- tinued to escape from the plant, and were collect- ed in the upper part of tlie receiver. In the course of half an hour, a considerable quantity of permanent gas was obtainecL A part of this gas, after cooling, was transferred to a phial, in which was a small quantity of atmospheric aii\ On pre- BRAGON ROOT. 57 seating a lighted paper to the mouth of this phi- al, it exploded with a very distinct report. An- other portion of the gas was agitated with lime water, which it rendered turhid. This circum- stance was prohably owing to the mixture of car- bonic acid disengaged from the plant, or from the water by boiling. From the above experiments, which circum- stances did not permit me to pursue, it appears that the acrimony of the Arum resides in a prin- ciple having no affinity for water, alcohol, or oil, being highly volatile, and, in a state of gas, in- flammable. The products of its combustion, as well as its other affinities, remain to be investi- gated.* The acrimony of the Arum when fresh is too powerful to render its internal exhibition safe. The roots, when dried whole, retain a small por- tion of their pungency, and in this state they have been given by some practitioners in the country for flatulence, cramp in the stomachj ^c. also for * The acrimony of the Ranunculi, which approaches that of the Arum, is lost by drying, yet is soluble in water, and passes over with it in distillation. That of Polygonum hydropiper disappears in de- coction and distillation. The same takes place with several other acrid plants which I have examined. Some inquiries into the acrid principle of vegetables I am in hopes to render more mature at a fu- ture period. 58 ARtJM TRIPHYLLtJM. asthmatic affections. As topical stimulants, they promise to be nsefnl when any method shall have been discovered of fixing and preserving their ac- rimony. The late Dr. Barton of Philadelphia ob- serves, that " the recent root of this plant boiled in milk, so as to communicate to the milk a strong impregnation of the peculiar acrimony of the plant, has been advantageously employed in cases of consumption of the lungs." This statement how- ever should be qualified by the recollection, that the Arum imparts none of its acrimony to milk upon boiling. An impression of this kind can only have been received from a partial mixture of the substance of the root with the milk. The root contains a large proportion of very pure white fsecula, resembling the finest arrow root or starch. To procure this, the fresh root should be reduced to a pulp, and placed on a strainer. Repeated portions of cold water should then be poured on it, which in passing through the strainer carry with them the farinaceous part, leaving the fibrous portion behind. The fsecula thus obtained, loses its acrimony on being thor- oughly dried, and forms a very white, delicate and nutritive substance. Dr. M'Call of Georgia found these roots to yield one fourth part of their weight of pure amylaceous matter,— It is not uncommon DRAGON ROOT. 59 for a nutritious fsecula to exist in pungent and poi- sonous roots. The Laplanders prepare a whole- some bread from the acrid roots of Calla palus- tris, and the juice of the Cassava, or bread root tree of the West Indies, is known to be high- ly deleterious wliile recent. [JSTote F.] BOTANICAL REFERENCES. LiNN^TJs, sp. pi. — WiLiDENOW, iv. 480. — AiToiv, Eort KeWc lii. 315. — Waiter, Carol. 224. — Michaux, Fl. ii. 188. — Pursh, ii. 399. Dracunculus s. Serpentaria triphylla, &c. — Bauhu?", Fin, 195. — Arum s. Arisarum, &c. — MoRisojir, Hist, iii. 547, S. 13, t, 5. — Plukenet, t. 77, J. 5. also t. 376, f. 3. MEDICAL REFERENCES. ScHtEPF, Mat. Med. 133. — Rush, ii. 301. — Bartoiv, Coll. 29, &c. — M'CAiiLjMi Philad. Med. and Phys. Journal^ ii. 84. — Tuach- ER, Disp, 153. — CuTXER, Mem. Jlmer. Jlcad. i, 48r. PLATE IV. Fig. 1. Anim triphyllum. Fig. 2. Spadix with anthers. Fig. 3. Spadix with germs. Fig. 4. Longitudinal section of the roofi COPTIS TRIFOLIA. Gold thread. PLATE r. X HE dark sphagnous swamps, "which in the northern partis of our continent are covered with a perpetual shade of firs, cedars and pines, are the favourite haunts of this elegant little ever- green. The coldest situations seem to favour its growth, and it flourishes alike in the morasses of Canada and of Siberia. On our highest mountain tops it plants itself in little bogs and watery clefts of rocks, and perfects its fructification in the short summer allowed it in those situations. I have gathered it upon the summit of the Ascutney in Vermont, and on the Alpine regions of the White mountains. It is here that in company with the Diapensia and Azaleas of Lapland, the blue Men- ziesia, the fragrant Alpine Ilolcii ;, ; ?id other plants r/.r. Tia.R GOLD THREAD. 61 of high northern latitudes, it forms the link of bo- tanical connexion between the two continents. When in situations like this, we seem transported to the frigid zone, and to be present at the point where the hemispheres approach each other, as if to interchange their productions.* In the second volume of the Amcenitates Ac- ademicse is a description and imperfect figure of this plant as brought from Kamschatka, by Hale- nius. He describes it by the name Eelleborus trifolius^ with the observation, " Minima est hiec planta in suo genere, attamen spectabilis." Sub- sequent botanists have ranked it with the Helle- bores, until Mr. Salisbury very properly separat- ed it from a family of plants, with which it wholly disagrees in habit, and constituted a new genus by the name of Coptis, This genus is character- ized by the following marks. Calyx none ; petals Jive or six, caducous ; nectaries five or six, cu- cullate; capsules from five to eight, pedicelled, leak- ed, many seeded. The species trifolia has ternate leaves, and a onefiowered scape, * " Non sine admiratione vidi non solum multas cum rarissimis nostris plantis Lapponicis communes, sed etiam alias, partim ignotas omnino, partim minirae tritas ; et denique quasdam etiam cum Cana- densibus easdem, argumento Canadam a Camscatca non longe dista- re, uti sequentes antea in sola America boreali visse, nunc etiam in estrema ora Siberiee." dmmniiaies Academiccs, ii. 310. 6S COPTIS TRIFOLIA. In botanical arrangements, the Coptis will fol- low the Hellebores, from which it was taken, re- maining in the class and order Polyandria, Folygy- nia, with the Multisiliquse of Linn sens and the Eanunculacese of Jussieu. The roots of this plant, from which the name of goldthread is taken, are perennial and creeping. On removing the moss and decayed leaves from the surface of the ground, they discover them- selves of a bright yeUow colour, running in every direction. The bases of the new stems are in- vested with a number of yellowish, ovate, acumi- nate stipules. Leaves ternate, on long slender petioles ; leafets roundish, acute at base, lobed and crenate, the crenatures acuminate ; smooth, firm, veiny. Scape slender, round, bearing one small, starry white flower, and a minute, ovate, acute bracte at some distance below. Calyx none. Petals ^\e, six or seven, oblong, concave, white. Nectaries five or six, inversely conical, hollow, yel- low at the mouth. Stamens numerous, white, with capillary filaments and roundish anthers. Germs from five to seven, stipitate, oblong, com- ^ pressed ; styles recurved. Capsules pedicelled, umbelled, oblong, compressed, beaked, with nu- merous black oval seeds attached to the inner side. The root of this plant is a pure intense bitter, GOLD THREAD. 63 scarcely modified by any other taste. In distilla- tion it communicates no decided sensible quality to water. The constituent with which it most abounds is a bitter extractive matter, soluble both in water and alcohol. It seems destitute of resi* nous or gummy portions, since the residuum from an evaporated solution in alcohol is readily dissolv- ed in water, and vice versa. It is devoid of astrin- gency when chewed in the mouth, and it gives no indication of the presence of tannin or gallic acid when tested with animal gelatin, or with sulphate of iron. The abundance of the bitter principle is evinced by the acetate of lead and nitrate of sil- ver, both of which throw down a copious precipi- tate. The sulphuric, nitric, and muriatic acids occasion no change, and the muriate of tin gives only a slight precipitate, after some time standing. Of this article larger quantities are sold in the druggists' shops in Boston, than of almost any in- digenous production. The demand for it arises from its supposed efiicacy as a local application in aphthous, and other ulcerations of the mouth. Its reputation however in these cases is wholly unmerited, since it possesses no astringent or stimulating quality, by which it can act on the ul- cerated spots, and where benefit has attended its use, it is doubtless to be ascribed to other articles 64* COPTIS TRIPOLI A. possessing the above properties, with which it is usually combined. As a pure tonic bitter, capable of strengthen- ing the viscera and promoting digestion, it is en- titled to rank with most articles of that kind now in use. Its character resembles that of Gen- tian, Quassia, and Columbo, being a simple bitter without aroma or astringency. The tincture, made by digesting half an ounce of the bruised root in eight ounces of diluted alcohol, forms a preparation of a fine yellow colour, possessing the whole bit- terness of the plant. I have given it in various in- stances to dyspeptics and convalescents, who have generally expressed satisfaction from its effects, at least, as frequently as from other medicines of its class. A teaspoonful may be taken three times a day. In substance, it rests well on the stomach in doses of ten or twenty grains. It is however difficult to reduce to powder on account of the te- nacity of its fibres. BOTANICAL REFERENCES. Coptis ti-ifolia Salisbury, Lin. Trans, viii. 305. — ^Pursh, ii. 390. — Helleborus trifolius, sp. pi. — WiiiD. ii. 1338. Kalm, Travels, iii. 379. — LEPECH.ifer i. 190. — Paiias, Jlfer. iii. 34. — Oeder, F. Dan. t. 566.— Michaux, Fl. i. S^S.^Amccn. dead, ii. 356, t. 4./. 18. GOLD THREAD. 05 MEDICAL REFERENCES. Helleborus trifolius, Bart. ColL Nigella. — Cutlee, Amer, dead. i. 457. — ^Thacher, Bisp. 283. PLATE V. Fig. 1. Coptis trifolia with the root, leaves f Jlowers and last yearns fruit. Fig, 2. MctarieSf stamens, and pistils magnijied. I Fig. 3. Section of a capsule shewing the seeds. ARBUTUS UVA URSI. Bear berry. PLATE ri, -T EW shrubs are more extensively diffused throughout the northern hemisphere, both in the old and new continents, than this trailing ever- green. We are told that it abounds in the nortli- ern parts of Europe, in Sweden, Lapland, and Ice- land, and extends southerly to the shores of the Mediterranean, In Siberia it is also found, and is represented as abundant on the banks of the Wolga. In North America it grows from Hud- son's bay as far south, at least, as the central parts of the United States. It occupies the most barren places, such as gravelly hills and dry, sandy woods, and covers the ground with beds of considerable extent. ri. yj Kn.l. Fi^. M. i{g.m. ^ F^.V. BEAR BERRY, 67 The family of plants bearing the name of Ar- butus have for their distinctive marks a jive-part- ed calyx, an ovate corolla, pellucid at base ; and a superior, five-celled berry. They are closely connected to the Vaccinia or whortleberries, from which they differ principally in the situation of the berry, which in the Arbutus gro\^s above the calyx, and in the Vaccinium below it.^ — Both these genera, at least the American species, prop- erly belong to the class Becandria and order Mano- gynia. The Linna3an natural order is Bicornes. Jussieu has them among his Ericce. The species Uva ursi. Bear's grape or Bear- berry is known from the rest by its procumbent stem and entire leaves. — It trails upon the ground, putting out roots from the principal stems,, and tending upward with the young shoots^ only. The cuticle is deciduous, and peels off from the old stems. Leaves scattered, obovate, acute at base, attached by short petioles, coriaceous, evergreen^ glabrous, shining above, paler beneath, entire, the margin rounded, but scarcely reflexed, and in the young ones pubescent. Flowers in a short cluster on the ends of the branches. Peduncles reflexed, furnished at base with a short acute bracte under- neath, and two minute ones at the sides. Calvx of five roundish segments, of a reddish colour and 68 ARBUTUS UVA URSI. persistent. Corolla ovate or urceolate, white with a reddish tinge, transparent at base, contracted at the mouth, hairy inside, with five short, reilex- ed segments. Stamens inserted at the base of the corolla with hairy filaments, and anthers with two horns and two pores in each. Germ round, style straight, longer than the stamens, stigma simple. Sectary a black indented ring, situated below the germ, and remaining tiU the fruit is ripe. Ber- ries globular, depressed, of a deep red, approach- ing scarlet, containing an insipid, mealy pulp, and . about five seeds, which in the American plant co- here strongly together, so as to appear like the nu- cleus of a drupe. The leaves and stems of the Uva ursi are used in Sweden and Hussia for the purpose of tanning leather. According to Linnseus, large quantities are annually collected for this use. When chewed in the mouth, the leaves have an astringent taste, combined with some degree of bitterness. The result of such chemical trials as I have made with them, shews that they abound in tannin, which is probably their chief active con- stituent. A solution of gelatin occasions a copi- ous precipitate ; sulphate of iron an equally co- pious one of a black colour. Mtrate of mercury and lime water gave large precipitates from the BEAR BERRY. 69 decoction, the first of a light green, the last of a brownish colour. Of the existence of gallic acid, at least as it exists in galls, I have found no suffi- cient proof. The decoction does not redden vege- table blues, and the black precipitate with the sul- phate of iron soon subsides, leaving the fluid nearly colourless. The quantity of resin, mucous mat- ter and extractive, provided they exist in this plant, must be minute ; since the decoction was not ren- dered turbid by the addition of alcohol or ether, nor the tincture by the addition of water, although after standing twenty four hours, some slight floc- culi appeared. Muriate of tin produced no precip- itation from the decoction, though it gave one from the tincture. Acetite of lead and nitrate of sil- ver gave large precipitates. "Water distilled from this plant, suffered no change with sulphate of ii'on, or muriate of tin. Professor Murray of Gottingen, finding a great- er amount of soluble matter taken up by water than by alcohol, considers the former as the best menstruum for this article. A similar inference from the American plant was made by Dr. John S. Mitchell in an inaugural dissertation, published at Philadelphia in 1803. For medical uses, 31ur- ray prefers the decoction to the infusion. yO ARBUTUS UVA URSI. The Uva ursi was probably known to the an- cients, as it grows in all the southern parts of Eu- rope. Clusius thinks it was the u^ktov o-TccCpuXti of Galen, celebrated by him as a remedy in hemop- tysis, and described as follows. "Uva ursi in Ponto nascitur, planta humilis et fruticosa. folio Memaicyli, fructum ferens rubrum, rotundum, ffustu austerum." But it is well known that the brief and imperfect descriptions of the ancients were productive of little else than uncertainty in Botany. In modern times the Uva ursi was brought into notice about the middle of the eighteenth century by De Haen, as an efficient remedy in nephritic and even in calculous cases. It had been previously in use for these complaints in Spain, at Naples and Montpellier, and as a gener- al astringent, at a still earlier period. Its reputa- tion was still further augmented by subsequent dissertations, published upon its properties, and different sets of experiments were instituted to ascertain if it were not actually capable of dissolv- ing the stone of the bladder. The results most in favour of its solvent power were those of Girardi,^ who diminished the weight and consistency of uri- nary calculi, by digesting them in a preparatioa of this plant. It appears however that the prep- BEAR BERRY. 71 aration, wliich he employed, was an acid liquor, obtained by a destruf tive distillation of the leaves, and probably not superior to other weak acids in its solvent powers. On the other hand, Professor Murray found what might reasonably be expect- ed, that these calculi were not materially affected by long digestion in a decoction of this plant at various temperatures. The attention of many medical writers has been called to the properties of this medicine, and their reports as to its success are extremely various. Among its greatest friends, are De Haen, Professor Murray, and Dr. Ferriar ; while of those whose opinion is more unfavourable, are Sauvages, Haller, Donald, Munro and FothergiU. Dr. CuUen adopts the opinion of De Heucher, that the symptoms of calculus generally are suscepti- ble of relief from astringents, and believes that on this principle the Uva ursi is capable of mitigat- ing complaints arising from that source.* In this country the Uva ursi has acquired the good opinion of practitioners of medicine in re- * In the preface to the third volume of Medical Observations and Inquiries, published at London, it is stated in very general terms, that the Uva ursi had been prescribed unsuccessfully hj msnnj of the mem- bers of the Society of Physicians in London. Dr. Woodville, in his Medical Botany, has unfortunately misquoted this passage, by read- ing " successfully" instead of" unsuccessfully." 7S ARBUTUS UVA URSI. peated instances. Professor Wistar of Phila- delphia, as cited by Dr. Mitchell, has in several cases found symptoms like those of urinary calcu- lus completely removed by this medicine. But these could not probably have been cases of real calculus. The late Professor Barton found the plant of much service in his own case of nephrit- ic paroxysms, alternating with gout in the feet. From the various testimonies which have been given respecting the properties of this article, we are not warranted in believing it to possess any real lithontriptic power. At the same time it un- doubtedly proves a palliative for calculous symp- toms in many cases. I have repeatedly watched its effects in parox- ysms of nephritis, brought on by gravelly concre- tions, and am on the whole inclined to believe in its tendency to allay sensibility in these cases, and to hasten the relief of the symptoms. It ought generally to be preceded by evacuationSj and may be advantageously accompanied with opium. — In cases of dysury arising from a vari- ety of causes, I have given the decoction of this plant with very satisfactory success in repeated instances. The other diseases in which this plant has been recommended are, catarrhus yesicse, leucorrhsea BEAR BERRY, 73 mid gonorrhsea. Ali these complaints it has doubt- less cured, but is at the same time inferior to other medicines in use for the same purposes. Some years ago the Uva ursi was recommend- ed as a remedy in pulmonary consumption bvBr, Bourne of Oxford in England, and by other wri- ters in the periodical works. It was stated to have a very sensible effect in diminishing hectic fever, and abating the frequency of the pulse de- pendent on it. We do not find however that sub- sequent experience has justilied the expectations formed of it in this disease. In Dr. Mitchell's experiments on the pulse with this medicine, it appears that the pulsations were sometimes, not always, slightly increased af- ter taking it, but that in every case they soon sunk below the natural standard, and remained so for some time. Of the powder of the leaves of Uva ursi, from one to two scruples may be given to most patients. Br. Ferriar's dose in nephritis was from five to ten grains, but a larger quantity is more effec- tual, and is readily borne by the stomach. The decoction may be made from half an ounce of the leaves boiled for ten minutes in a pint of water. From a wine glass to a gill of this may be taken every hour. 10 74 ARBUTUS UVA URSI. BOTANICAL REFERENCES. Arbutus Uva ursi, LiNN-aEUs, Fl. Lapponica, 162, t. vi./. 3.— * Oeder, Fl. Ban. t. 33. — ^Woodville, i. t. 70. — Smith, Fl. BriU 443. — Engl. Bot. t. 714. — Michaux, Fl. i. 249. — Pursh, i. 282. Uva ursi, J. Batjhin, i. 523. — Ciusius, Mspan. 79. — Lobei, Icon.}. 366.-— PAKKiNSOif, theatr. 1457. — ^Vitis Idsea, Raius, HisU 1489, MEDICAL REFERENCES. Murray, Apparatus Med. ii. 64. — Girardi, de Uva ursina, &c. — De HABJf, Ratio medendh ii. 160, &c. — Satjvages, J^'osol. iii. 2, 200. — D. Munro, Mat. Med. iii. 288. — Fothergill, Med, Obs. 144. — Axexander, Exp. essays, 151. — Ferriar i. 109. — Hebbrden 79, 360. — Davie, Med. and Phys. Journal, xv. 347. — BouRivE, in ditto, xiv.^463. — Schcepf, 67. — Mitchell, Inaugu- ral Thesis. PLATE VI. Fig. 1. »:irhutus Uva ursi, the American vanety. Fig. 2. The magnijied corolla opened, shewing the insertion of the stamens. Fig. 3. Calyx, nectary, germ, and stijle magnified. Fig. 4, Calyx and nectary. Fig. 5. Berry. ^t: /■/ . / //. • Aim ^^mg'MMafya^ ^rt//a^/^/fM» SAI^GUINARIA CANADENSIS^ Blood root PLATE VIL Among the earliest visiters of spring the hota= nist will find in almost any part of the United States the Sangiiinarici Canadensis, Its fine white flowers proceeding from the bosom of a youngs convoluted leaf, become visible in the woods, in Carolina, in the month of March, and in New En- gland, toward th^ end of x\pril. Its most com- mon name is Blood root. It has also the appella tion of Puccoon, Turmeric, Med root, ^c. It is the only species we at present possess of the genus Sanguinaria, distinguished by a two leaved caly^ eight petals, and an ohlong capsule, with one cell and many seeds.^— Class Polyandria, order Mono- gynia» Natural order Mhceadecv, L, Papaveracew^ Jiiss, 7Q SANGUINARIA CANADENSIS. The flower and leaf proceed from the end of a horizontal, fleshy, abrupt root, fed by numerous radicles. This root makes ofi'sets from its sides, which separate as the old root decays, acquiring by this separation the abrupt or premorse form. Externally the colour of the root is a brownish red. Internally it is pale, and when divided emits a bright orange coloured juice from numerous points of its surface. The bud or hybernaculum, which terminates the root, is composed of succes- sive scales or sheaths, the last of which acquires a considerable size, as the plant springs up. By dissecting this hybernaculum in the summer or autumn, we may discover the embryo leaf and flower of the succeeding spring, and with a com- mon magnifier, even the stamens may be counted. The Sanguinaria is smooth throughout. The leaves grow on long channelled petioles. When spread out, they are reniform or heart shaped, with large roundish lobes separated by obtuse si- nuses. The under side is strongly reticulated with veins ; it is paler than the upper, and at length becomes glaucous. The scape is round, rises in front of the petiole, and is infolded by the young leaf. The calyx consists of two concave, ovate, obtuse leaves, which are perfect in the bud, but fall off when the corolla expands. Petals eight, BLOOD ROOT. 77 spreading, concave, obtuse, the alternate or ex- ternal ones longer, so that the flower has a squai'e appearance. This is its natural charac- ter, although cultivation sometimes increases the number of petals. Stamens numerous, with ob- long yellow anthers. Germ oblong, compressed, style none, stigma thick, somewhat two lobed. Capsule oblong, acute at both extremities, two valved. Seeds numerous, roundish, compressed, dark shining red, half surrounded with a peculiar white vermiform appendage, which projects at the lower end. After the flower has fallen, the leaves continue to grow, and by midsummer have acquired-so large a size as to appear like a different plant. The root of this vegetable is the only part which I have submitted to chemical examination. The experiments made on this substance, gave evidence of the following constituent principles. 1. A peculiar resin. Alcohol comes ofl*from the root strongly impregnated with its colour and taste. This solution is rendered turbid by the addition of water. When evaporated to dryness, it leaves a residuum partially, but not wholly soluble in water. When successive quantities of water have been agitated with the powdered root until the infusion comes off colourless, alcohol acquu-es 78 SANGUINARIA CANADENSIS. a colour from the remainder. jEtlier receives from the root a yellowish colom', and when eva- porated, leaves the resin nearly pure. In this state it is moderately adhesive, of a deep orange colour, bitter and acrid, diffusible, bat not soluble in water. The resin may also be precipitated in small quantities from alcohol by water. S. A bitter principle. Both water and alcohol acquire a strong bitter taste when digested on the root. From both these solutions a copious pre- cipitate is thrown down by the nitrate of silver and the acetite of lead. 3Iuriate of tin gradually renders the solution turbid, but without a precipi- tate. Oxymuriatic acid renders the alcoholic so- lution turbid, but produces no change in the wa- tery solution for some time. At length a precip- itate forms and slowly subsides; but produces no change in the watery solution. No precipitate was formed from the cold aqueous infusion in an hour by the sulphuric or nitric acids, by lime water, ni- trate of mercury, muriate of barytes, oxalate of ammonia, sulphate of iron, gelatine or hydro-sul- phuret of potash. After standing twenty four hours, a very slight precipitate was discovered from the lime water and nitrate of mercury onl}^ 3. An acrid principle. The acrimony resides in part in the resin, but is also communicated to BLOOD ROOT. 79 water. It is diminished by heat, yet it does not come over with water in distillation. 4. Fsecula. The infusion of the root in cold water is limpid. The hot infusion is viscid and glutinous and stiffens linen. From this solution the fascula is precipitated in a white powder by al- cohol. Nitric acid dissolves this precipitate, which may be again thrown down by alcohol. 5. A fibrous or woody portion. The beautiful colour of the root seems to re- side more in the resin than in any other princi- ple, since the alcoholic solution has always more than twice as much colour as the aqueous. Pa- pers dipt in these solutions receive a bright salmon colour from the tincture, but a very faint one from the aqueous infusion. This circumstance furnish- es an impediment to the use of this article in dyeing. The medical properties of the Sanguinaria are those of an acrid narcotic. When taken in a large dose it irritates the fauces, leaving an impression in the throat for considerable time after it is swal- lowed. It occasions heartburn, nausea, faintness, and frequently vertigo and diminished vision. At length it vomits, but in this operation it is less certain than other emetics in common use. The above effects are produced by a dose of from eight to twenty grains of the fresh powdered root. so SAN GUIN ARIA CANADENSIS. When given in smaller doses, such as produce nausea without vomiting, and repeated at fre- quent intervals, it lessens the frequency of the pulse in a manner somewhat analogous to the op- eration of Digitalis. This however is a seconda- ry effect, since in its primary operation it seems to accelerate the circulation. Exhibited in this manner, it has been found useful in several diseases. In still smaller doses, or such as do not excite nausea, it has acquired some reputation as a tonic stimulant. Professor Smith of Hanover, New Hampshire, in a paper on this plant, published in the London Medical Transactions, vol. i. states that he found the powder to operate violently as an emetic, pro- ducing great prostration of strength, during its operation, which continued for some time. He liad not known it to act as a cathartic. Snuffed up the nostrils, it proved sternutatory, and left a sensa- tion of heat for some time. Applied to fungous flesh it proved escliarotic, and several polypi of the soft kind were cured by it in his hands. He found it of great use in the incipient stages of pulmona- ry consumption, given in as large doses as the stomach would bear, and repeated. In cases of great irritation it was combined with opium. Some BLOOD ROOT. 81 other complaints were benefitted by it, such as acute rheumatism and jaundice. Professor Ives of New Haven* considers the Blood root as a remedy of importance in many dis- eases, particularly of the lungs and liver. He ob- serves, that in typhoid pneumonia, "in plethoric constitutions, when respiration is very difiicult, the cheeks and hands become livid, the pulse full soft, vibrating and easily compressed, — the Blood root has done more to obviate the symptoms and remove the disease," than any remedy which he has used. In such cases, he observes, " the dose must be large in proportion to the violence of the disease, and often repeated, until it excites vomit- ing, or relieves the symptoms." He infuses from a scruple to half a drachm of the powdered root in half a gill of hot water, and gives one or two tea- spoonfuls every half hour, in urgent cases, until the effect is produced. This treatment has often removed the symptoms in a few hours. Dr. Ives thinks highly of its use in influenza, in phthisis, and particularly in hooping cough. He also states, that given in large doses, sufficient to produce full vomiting, it often removes the Croup, if administered in the first stages. It has been given, he remarks, "for many years in the * Letter dated November 5, 1816. 11 82 SAUGUINARIA CANADENSIS. country, some physicians relying wholly on this remedy for the cure of croup." Dr. Macbride, of Charleston, S. C. who has contributed many judicious remarks on the medi- cinal properties of plants, to Mr. Elliott's excel- lent Botany of the Southern States ; informs me,* that he has found the Blood root useful in Hy- drothorax, given in doses of sixty drops, ter de die, and increased until nausea followed each dose. In a week or two the good eifect was evident, the pulse being rendered slow and regular, and the respiration much improved. In the same letter he observes, " In torpor of the liver, attended with colic and yellowness of the skin, a disease com- mon in this climate, I use the Puccoon with evi- dent advantage. We use it also in jaundice, but in this disease I do not trust exclusively to it. I prefer the pill or powder (dose from two to five grains) and vinous infusion, to the spirituous tinc- ture." The tincture of Sanguinaria may be made by digesting an ounce of the powdered root in eight ounces of diluted alcohol. This preparation pos- sesses all the bitterness, but less of the nauseat- ing quality, than the infusion. In the dose of a small teaspoonful, it is used by many practitioners * Letter dated December, 1816. BLOOD ROOT. 8S as a stimulating tonic, capable of increasing the appetite and promoting digestion. BOTANICAL REFERENCES. Sanguinaria Canadensis, Lin. sp<, pi. — Curtis, Botan. Mag^ t. 162. — AiToiv, Hort. ICe%v, ii. 222. — Waiter, Carol. 153.— MiCHAUx, Flora 1, 309.' — Pursh, ii. 366. — Sanguinaria minor, BixiENius, Elth. /. 326 and S. major, / 325 in t. 252. — Cheli- donium maximum acaulon Canadense Raius, Hist. 1887. — Ran- unculus Virg. albus. Parkinsoiv, Th. 326. — Chelidonium ma- jus Canad. acaulon Cornutus, Canad. 212. MEDICAL REFERENCES. ScHffiPF, 85. — Smith, Trans. Lond. Med. Society, i. 179.— » Bart. Coll. 28. — CuTiER, Mem. dmer. dead. i. 455. — Thacher>, Bisp. 331. GEEAMUM MACULATUM. Common CraneshilL PLATE nil. JLN common language the term Geranium in- cludes all that extensive tribe of plants comprised by the old genus of that name, and principally characterised by their beaked fruit and five seeds ■which are scattered by means of awns. L'Heri- tier has divided this family into three distinct gen- era, under different orders in the artificial class Monmlelphia. These are Erodium^ haviog five sta- mens, five nectariferous scales and glands, and the awns of the fruit twisted and bearded. Pelargoni' uin, which includes most of the Cape species so commonly cultivated among us, having about seven stamens, an irregular corolla, and a nectareous tube running down the peduncle. Lastly, Geranium having ten stamens, a regular corolla, five nee- yj. \iu. COMMON CEANESBILL. 8S tariferous glands at the base of the longer fila- ments, the awns of the fruit neither bearded nor twisted. To this division belongs the plant under consideration, which has the following specific character. Erect, hairy backward ; stem forked; leaves opposite, three or jive parted, cut; peduncles mostly two flowered ; petals, ohovate, entire, Jussieu has formed a natural order by the name of Gerania, which nearly corresponds to the Gruinales of Linnseus. Although we have few species of Geranium in the United States, yet the present species, by its extensive diffusion, is a sufficient representative of the race. It is very common in low grounds, about Boston and Philadelphia, in the Carolinas, and in the western country upon the banks of the Ohio and Illinois. The root of Geranium maculatum is perennial, horizontal, thick, rough and knobby. In most plants it sends up a stem and several root leaves. The leaves are spreading, hairy, divided in a pal- mate manner into three, five, or seven lobes, which are variously cut and toothed at their extremi- ties ; those of the root are on long petioles, those at the middle of the stem opposite and petioled, those at the top opposite and nearly sessile. The stem is erect, round, hispid with reversed hairs, 86 GERANIUM MACULATUM. dichotomous, with a flower stalk in the fork. Sti- pules and bractes linear, dilated at base. Pedun- cles round, hairy, swelling at base, generally two flowered. Calyx of five oblong, ribbed, mucron- ated leaves, with the parts, which are outermost in the bud, hairy. Petals five, obovate, not emargi- nate, of a light purple colour, which is deeper when the plant grows in the shade, marked with green at the base. Stamens ten, erect or curving outward, the alternate ones a little longer, with nectariferous glands at the base ; filaments dilat- ed and united together at base ; anthers oblong, deciduous, so that the number frequently appears less than ten. Germ ovate ; style straight, as long as the stamens ; stigmas five, at first erect, afterwards recurved. Capsule hje seeded, sur- mounted by a long straight beak, from the sides of which when ripe are separated five thin, flat awns, which curl up, having cast off the seed contained in the cell at the base of each. The root of the Geranium, which is the part to be used in medicine, is internally of a green col- our, and when dry is exceedingly brittle and easi- ly reduced to powder. It is one of the most pow- erful astringents we possess, and from its decided properties, as well as the ease of procuring it, it may well supersede in medicine many foreign ar- COMMON CRANESBILL. 87 tides of its class which are consumed among us. The experiments, which I have made upon this root, have been principally directed to the exami- nation of its astringent qualities. A drachm of the powdered root was steeped in two ounces of cold water and the infusion filtrat- ed. Successive portions of water were add- ed until the liquid came off colourless and taste- less. The collected infusion had a pale greenish colour, and a styptic, austere taste. It did not redden vegetable blues. To half this infusion was added a drachm of gelatin in solution. The liquor instantly became of a milky whiteness, and a copious white precipi- tate was thrown down. This precipitate was dri- ed and assumed a semi-transparent, horny ap- pearance. Its weight was eleven grains. A drachm of kino treated in the same man- ner was rendered turbid, but gave a very scanty precipitate with the gelatin. To portions of the same infusions was added a solution of the muriate of tin. In both of them a greenisli precipitate was formed, but that of the Geranium was much the most immediate and abundant. The sulphate of iron struck a dark purple col- our with the infusion of Geranium. The com- a& GERANIUM MACULATUM. pound remained principally suspended at the end of twenty four hours, and when used in writing had the appearance of common ink, but in a few days changed to a dull brown colour. A por- tion of the fresh infusion was distilled, but the li- quid which came over was not altered in colour by the sulphate of iron. The above experiments indicate the presence of tannin and gallic acid, the former in large quan- tities, in the root of the Geranium^ The propor- tion of tannin seems considerably to exceed that in the kino of the shops. The gallic acid is in- dicated by the dark precipitate remaining in so- lution. This is Berthollet's criterion. It differs however from the acid of oak galls in not reddening vegetable blues, and not passing over in distillation. Alcohol and proof spirit readily dissolve the active constituents of the Geranium. The tinc- ture has a great sensible astringency, and i& a convenient mode of keeping tlie article for use. The Geranium has been repeatedly employed in medicine by various practitioners in this coun- try. I have found it useful in a number of cases, where astringents were capable of rendering ser- vice. It is particularly suited to the treatment of such discharges as continue from debility after the removal of their exciting causes. The tine- COMMON CRxlNESBILL, 89 ture forms an excellent local application in sore throats and ulcerations of the mouth. Its internal use has been recommended in dvs- entery and cholera infantum, but astringents are not always admissible in these complaints, at least in their early stages, during the existence of much actiye inflammation, or during the presence of any substance requiring to be removed. The Geranium may be used in powder in ex- tract, or in tincture. Its doses are similar to those of kino and catechu, a drachm or two of the tincture, twenty or thirty grains of the pow- der, and a quantity somewhat less of the extract. BOTANICAL REFERENCES. Geranium maculatum, Sp.pl. Wilidejvow, iii. 705. — GEoiiro- vius, Virg. 101. — Waiter, Carol. 175. — Michaux, ii. 35. — . PuRSH, ii. 448. — G. caiile erecto, herbaceo, foliis oppositis, quin- quepartitis, incisis &c. Caa'^aiviiles, diss. t. 86,/. 2. — G. batra- chioides, Americanum, maculatum, floribus obsolete cceruleis, T)lLL.Elth. 158. t 131,/. 159. MEDICAL REFERENCES. ScHffiPF, 107. — Bart. Coll. 7. — Cutler, Mem, Mier. Jlcailt i. 469 Thacher, Disp. 224. PLATE VIIL Fig. 1. Geranium maciilatnm. Fig. 2. The fruit. Fig. 3. The root, IS TEIOSTEUM PERFOLIATUM. Fever root PLATE IX. X HIS is rather a solitary plant, and tliougli met with in most parts of the United States, it rarely, I believe, occurs in large quantities. About Boston it is found in several places at the borders of woods in rich, shady situations. Its common names are Fever root and Wild ipecac.^ Pursh observes, that it is rare, and generally occurs in limestone soils. With us it flowers in June and ripens its fruit in September. The genus Triosteum is found in the class * The quaint appellation of Dr. Tinker's weed, which has heen bestowed on this plant, is thus gravely commented on by Poiret. *' Ses racines et celles de Fespece precedente passent pour emeti- ques ; le docteur Tinkar est le premier qui les a mises en usage, et qui a fait donner a cette plante par plusieurs habitans de I'Amerique septentrionale le nom d' herbe saiivage du docteur Tinkar.''[ JPLIX. -^^ Fi.K II rig. m /,vV..,^//A '"/////// A'; FEVER ROOT. 91 Pentandria and order Monogynia. Its natural affinities place it among the Aggregatce of Lin- naeus and the Capi^ifolia of Jussieu. It is charac- terized by a monopetalous, five-lohed^ unequal co- rolla ; a calyoc as long as the corolla ; and a ber- ry with three cells and three seeds. The species perfoliatum differs from the rest in having its leaves connate, and itsfiotvers sessile and whorled. The root of this plant is perennial and subdi- vided into numerous horizontal branches. The stem is erect, hairy, fistulous, round, from one to four feet high. The leaves are opposite, the pairs crossing each other, connate, ovate, acumi- nate, entire, rather flat, abruptly contracted at base into a sort of neck, resembling a winged petiole. This portion varies in width, as Michaux has expressed it, "foliis latins, angustiusve con natis," In general it is narrow when the plant is in flower, as represented in the figure; and wider when it is in fruit. The flowers are axillary, sessile, five or six in a whorl, the upper ones generally in a single pair. Each axil is furnished with two or three linear bractes. The calyx consists of five segments which are spreading, oblong-linear coloured, unequal, persistent. Corolla tubular, curving, of a dull brownish purple, covered with minute hairs, its base gibbous, its border open and 9S TRIOSTEUM PERFOLIATUM. divided into five rounded, unequal lobes. Stamens inserted in tlie tube of the corolla, hairy, with oblong anthers. Germ inferior, roundisli ; style longer than the corolla; stigma peltate. The fruit is an oval berry of a deep orange yellow,* hairy, somewhat three sided, crowned with the calyx, containing three cells and three hard, bony, furrowed seeds, from which the name of the genus is taken. This plant was made the subject of an inter- esting communication to the Linn^ean society of Kew England, by Dr. John Randall. The exper- iments made by him on its medical uses and phar- maceutical preparations were numerous, and serve to throw much light on its properties. In trying the solvent powers of water and alcohol, he found that water afforded a much greater quanti- ty of extract than alcohol, and that the spirituous extract was perfectly soluble in water, whence he infers that no resin in a pure state exists in the plant. He discovered no volatile oil by distilla- tion, nor any other principle of activity in water distilled from the plant. He concludes also, that * Pursh observes that the flowers and berries are purple. In all the specimens I have examined, which have not been few in number* the fruit was of a bright orange colour. If Pursh has seen a plant %vith purple berries, it is probably a diiferent species from the true plant of Linnseus and Diilenius, which had ^^fructus lutescentes,^^ FEVER ROOT. 98 no free acid exists in this vegetable. Of the dif- ferent parts submitted to examination, the leaves yielded the greatest quantity of soluble matter, but the root afforded that of the greatest activity. By decoction and evaporation with water an ounce of the dried stalks afforded one drachm of ex- tract ; an ounce of the dry roots, two drachms and two scruples, and the same quantity of leaves half an ounce. From a similar treatment of equal portions with alcohol, rather more than half the above quantities of extract were obtained. The sensible qualities of the root were found essentially different from those of the herb. Both of them possess a large share of bitterness, but the root has also a nauseous taste and smell, some- what approaching to those of ipecacuanha. The medical properties of the Triosteum are those of an emetic and cathartic. In the above disserta- tion, about thirty cases are detailed, in which dif- ferent preparations and quantities of the article were given to various persons with a view to their medicinal effects. The general inference to be made from them is, that the bark of the root acts with tolerable certainty as an evacuant upon the alimentary canal, both hy emesis and catharsis. When given alone, either in powder or decoction, the instances of its failure were not many, and 94> TRIOSTEUM PERFOLIATUM, when combined with calomel, its operation was at- tended with a certainty, hardly inferior to that of jalap. The aqueous and spirituous extract of the root were likewise efficacious, and nearly in an equal degree. Preparations made from different parts of the herb possessed much less activity, the decoction of the leaves operating only as a diapho- retic, and that of the stalk producing no effect. The late Professor Barton of Philadelphia, in his Collections toward a Materia Medica of the U- iiited States, speaks of this plant as a mild and good cathartic, sometimes operating as a diuretic and in large doses as an emetic. My own experience with this plant has not been extensive, yet sufficient to satisfy me of its medicinal power. Where I have administered it, it has generally proved cathartic, a larger dose however being requisite for this purpose, than of jalap or aloes. It has sometimes failed to pro- duce any effiact, and I am inclined to believe that its efficacy is much impaired by age. Those who may incline to employ it, will do well to renew their stock annually, and to keep the powder in close stopped phials. A dose of the bark of the root in powder is twenty or twenty five grains, and of the extractj a somewhat smaller quantity. FEYER ROOT. 95 BOTANICAL REFERENCES. Triosteum perfoliatiira, Lin. sp. pi. Aiton, Hort. Ketv, i. 234. — PuRSH. i. 162. — Triosteum majiis, Michaux, Fl. i. 107. — T. floribus verticLllatis, sessilibus, Gronov. 31. — Triosteosper- mum latiore folio, flore rutilo, Dij^lenius, Elth. t. 293. /. 378. MEDICAL REFERENCES. ScHOEPF, 23. — ^Bart. Coll. 29. PLATE IX. Fig. 1. Triosteum perfoliatum. Fig. 2. .5 Jloxver separated. Fig. 3. The corolla opened, shewing the stamens and style. Fig. 4. The calyx. Fig. 5. The fruit, crowned with the calyx. Fig. 6. The same dissected to shew the three seeds. Fig, 7. d seed. EHUS VERmX. Poison Sumach or Dogwood, FL^TE X. Xhe fine, smooth foliage of the Rhus vernis render it one of the most elegant of our native shrubs, while its well known poisonous qualities make it an object of aversion, and deter most per- sons from a near inspection of its structure and characteristics. From Canada to Carolina it is a common tenant of swamps and meadows, usually attaining the height of ten or fifteen feet, but sometimes rising into a tree of twice that altitude. The names of Poison tree, Poison wood, Poison ash, ^c. are applied to it in different parts of the United States. In Massachusetts it is universal- ly known by the name of Dogwood, This appel- lation, being applied throughout the country to Cormis florida, serves to shew the fallacy of de- >>'/. J- POISON SUMACH. ^7 pending on vulgar or provincial names for the distinction of plants. A mistake of very injuri- ous consequence might easily arise from the confu- sion of the English names of two trees so dissimi- lar in their qualities. The class Pentandria and order Trigynia ; the Linnsean order Biimosm and the Jussieuean Tere- bintacece include the genus to which this shrub belongs. The generic character consists in an inferior, jive-parted calyx, a corolla of five petals^ and a berry tvitli one seed. The Ehus vernix has its leaves annual, pinnate, glabrous ; its leafets ob- long, entire, acuminate ; its panicle lacv, and its fiowers diodcious. The trunk of the poison sumach is from one to five inches in diameter, branching at top, and covered with a pale greyish bark. The wood is light and brittle, and contains much pith. The ends of the young shoots and the petioles are usu- ally of a fine red colour, which contributes much to the beauty of the shrub. The leaves are pin- nate, the leafets oblong or oval, entire, or some- times slightly sinuate, acuminate, smooth, paler underneath, nearly sessile, except the terminal one. The flow ers, which appear in June, are very small, green, in loose axillary panicles. Where they appear not axillary, it is because the leat un- 13 98 RHUS VERNIX. der tliem lias been detached. Tlie barren and fertile flowers grow on different trees. The panicles of barren flowers are the largest and most branched. They are furnished with short, oblong bractes, and downy pedicels. The ca- lyx has five ovate segments, and the corolla five oblong, sigmoid petals. The stamens are longer than the petals, and project through their in- terstices. The rudiment of a three-cleft style is found in the centre. — In the fertile flowers, the panicles of which are much smaller, the calyx and petals resemble the last, while the centre is occupied by an oval germ, ending in three circular stigmas. The fruit is a bunch of dry berries or rather drupes of a greenish white, sometimes marked with slight purple veins, and becoming wrinkled when old. They are roundish, a little broadest at the upper end, and compressed ', containing one white, hard, furrow- ed seed. A tree, supposed to be the same with the Rhus vernix, grows in Japan, and furnishes the celebrated black varnish of that country. A controversy respecting the identity of the Japanese and American species, was carried on in the forty ninth and fiftieth volumes of the London Philosophical transactions, by Mr. Philip Miller POISON SUMACH. 99 and Mr. John Ellis. The mass of evidence seems to justify the belief, that notwithstanding the re- moteness of their situation, they are one and the same species. The description of the oriental tree, given in Ksempfer's Amcenitates exotics, agrees very closely with that of the American species. [JVo^e G.] Like our native Rhus, the Japanese tree possesses a poisonous influence, and frequently causes a severe cutaneous affection in those who approach or gather it. It only re- mains to shew, that a varnish may be obtained from the American Ehus vernix, to furnish strong presumptive evidence of the identity of the two. If an incision be made in the bark of our Rhus vernix in the spring or autumn, a quantity of thick viscid fluid immediately exudes, and sometimes with such rapidity as to drop off be- fore it can be collected. This juice has an Dpaque, whitish appearance, and a strong, pene- trating, disagreeable smell. On exposure to the atmosphere, its colour soon changes to a deep black. It is extremely slow in drying, and per- manently retains its black colour. In the month of October, 1814, with the as- sistance of Dr. Pierson, whose case is afterwards described ; I collected several ounces of this juice from a thicket of trees in Brighton. Being col- 100 RHUS VERNIX. lected in a pliial, it retained its whitish colour, except at the surface, where it turned black from its contact with the air in the upper part, lliis juice was kept for more than two years without any change in its appearance. In cold weather it was extremely viscid, and flowed with difficulty. Different portions of this juice were submitted to chemical examination. It was perfectly insolu- ble in water, although upon boiling with it, it formed a thick emulsion. Alcohol dissolved it sparingly, and the solution was rendered turbid by water. jEther combined with it more large- ly, forming a thick, opaque compound. Strong sulphuric acid combined with it, producing a black solid mass. Alkalies also combined with it, and a strong solution of pearl ash dissolved a portion of it, which was afterwards precipitated hy sulphuric acid. It had an affinity for metallic oxyds, and powdered litharge, upon being boiled with it. rendered it nearly solid. In distillation at the heat of boiling water, nothing came over except a slight fdm upon the surface of the wa- ter. When the heat was raised to the boiling point of the juice, a quantity of thin, blackish, vol- atile oil came over, which dried up on being ex- posed to the air, leaving a slight coating on the surface of the vessel which contained it. The POISON SUMACH. lOl portion remaining in the retort was much inspis- sated, and upon cooling became nearly solid. Being desirous to try the effect of this juice, employed as a varnish, I applied a coating of it with a brush to different surfaces of wood, glass, tinned iron, paper, and cloth. These were ex- posed to the air and light during the whole of the months of July and August, at the expira- tion of which period they had not become dry. Each of the coatings was half fluid and adhesive, and had collected much dust. Upon the cloth and paper the juice had spread extensively, giv- ing them an oily appearance. Concluding from this experiment that the juice could not be usefully employed in its crude state, I endeavoured to render it more drying by the addition of litharge. The compound, which resulted from boiling with this oxyd, became dry in a short time, but was not distinguished for any remarkable degree of lustre. The third and last experiment proved more satisfactory. A quantity of the juice was boiled alone, until nearly all the volatile oil had escaped, and the remainder was reduced almost to the state of a resin. In this state it was applied while warm to several substances, which after cooling exhibited the most brilliant, glossy, jet black sur- 103 RHUS VERNIX. face. The coating appeared very durable and firm, and was not affected by moisture. It was elastic and perfectly opaque, and seemed calcu- lated to answer the purposes of both paint and varnish. The chemical constitution of the juice of the Rhus vernix seems, from the foregoing experi- ments, to be most analogous to that of the bal- sams, consisting chiefly of a resin and an essen- tial oil. The oil dissipates slowly at low temper- atures, approaching in this and some other res- pects to the character of a fixed oil. The resin, "when procured in contact with the atmospheric air, is black, opaque, and solid, rendered very ad- hesive, and at length fluid by heat. A very distressing, cutaneous disease, it is "well known, ensues in many persons from the con- I tact, and even from the effluvium of this shrub, I The poisonous influence which produces this af- fection is common to several other trees and plants, such as the Poison vine or Poison ivy, (Rhus radicans,) the Cashew nut, (dnacardium occidentale,) and the Manchineel, (Wppomane inancinella») Even the garden Rue, and com- mon Oleander, are said to ajffect some persons in a similar manner. — The Rhus vernix is the most formidable of this tribe which is found among us. POISON SUMACH. lOS and occasionally produces the most severe effects* It is however extremely various in its action, up- on persons of different idosyncrasies. Some can- not come within the atmosphere of the shrub, without suffering the most violent consequences. Others are but slightly affected by handling it, and some can even rub, chew, and swallow the leaves without the smallest inconvenience. The most formidable cases in persons subject to this poison, usually commence within twenty four hours after the exposure. The interval is sometimes longer, but more frequently shorter. The symptoms are generally ushered in by a sense of itching and a tumefaction of the hands and face. The swelling gradually extends over various parts of the body, assuming an erysipela- tous appearance. The inflamed parts become more elevated, acquiring a livid redness, attended with a painful burning sensation. Small vesicles now appear upon the surface, which extend and run into each other. They contain a transparent fluid, which by degrees becomes yellow, and at length assumes a purulent appearance. A dis- charge takes place from these vesicles or pustules, giving rise to a yellowish incrustation, which af- terwards becomes brown. In the mean time an insupportable sensation of itching and burning is \ \ 104 RHUS VERNIX. felt. The inflamed parts become excessively swollen, so that not unfrequently the eyes are closed, and the countenance assumes a shapeless and cadaverous appearance, which has been com- pared to that in malignant small pox. The dis- ease is usually at its height from the fourth to the sixth day, after which the skin and incrustations begin to separate from the diseased parts, and the symptoms gradually subside. It is not com- mon for any scars or permanent traces of the dis- ease to remain. Notwithstanding the violent character which it sometimes assumes, I never knew an authenticated case of its terminating fa- tally. It is however capable of occasioning the most distressing symptoms. Kalm, in his travels in North America, mentions a person who, by the simple exhalation of the Rhus vernix, was swol- len to such a degree, that " he was stiif as a log of wood, and could only be turned about in sheets." Dr. Thacher mentions a case, in which the head and body were swollen to a prodigious degree, so as to occasion the loss of sight for some time j and the patient recovered at the end of several weeks with the loss of his hair and nails. Of the cases which have fallen under my no- tice, the following affords a fair instance of the operation of this poison, as it ordinarily effects POISON SUMACH. 405 those who are constitutionally liable to it. On the 27th of October, 1814, Dr. A. L. Pierson, then a student of medicine, accompanied me to Brighton for the purpose of collecting the juice of the Rhus vernix, growing at that place. He had always supposed himself constitutionally exempt from, liability to the poison. The day proved warm, and the eflluvium from the incisions we had made in the trees was very powerful. We were engag- ed in the collection for upwards of an hour, dur- ing which he was less exposed than myself, be- ing absent a part of the time. His own account of the symptoms which followed this exposure is as follows : " I felt no unpleasant effects for six or seven hours after returning to Boston, About 8 o'clock P, M. I perceived the backs of my hands were swollen and puffy, but without pain or itching ; my forehead and upper lip were soon in the same state. On the morning of the S8th the tumefac- tion had increased, and I discovered various other parts of my body to be infected. The backs of my hands and wrists, which were the most advanced, began to show small w atery vesicles, No appli- cations were made till the nqon of this day. I then applied cloths dipped in lead water to one hand and wrist, and in a spirituous solution of the 14j 108 RHUS VERNIX. the coiTOsiye muriate of mercury to the other. From this and subsequent trials, I am induced to prefer the lead. The parts began to itch — the tumefaction increased — vesication began to take place on the swollen surface — small pustules formed and ran into each other, and at last some were formed as large as nutmegs. On the S9th, my eyes were nearly closed, in consequence of the swelling of my forehead, eyebrows and cheeks. The contents of the vesicles were perfectly lim- pid — inoculation from them to other parts had no effect — ■neither in this nor any subsequent stage. On the evening of the 30th, the inflam- mation appeared at its height. The burning sen- sation and itching were intolerable. I could scarce- ly discern any object. On the 31st, the pustules hegan to appear a little milky — and before night the inflammation was evidently on the decline. I this day applied an ointment, composed of Ung. Stramonii, 1 oz.— Subm. Hyd. c. Ammonia (white precipitate) 1 dr. mixed — with a very pleasant effect. It was now soothing, although before it had seemed to irritate, and produced pain when applied. !Xovember 1st, a very free desquama- tion began, first on my forehead, hands and wrists. And in just a fortnight I was enabled to leave my chamber, blessed with a new cuticle from the root POISON SUMACH. 107 of tbe hair on my forehead to my breast, from the middle of my forearm to the tips of my fingers, and on the whole inside of my thighs. The con- stitutional effects of this thorough vesication were but slight. During the first fire days, my pulses were increased from ten to twenty strokes in the minute. The time of duration of the inflamma- tory symptoms in this case accords pretty well with the account of Prof. Barton, who states, I think, the height of it to be on the fifth day. It is WLOi^th observing^ that the operation of the poi- son seemed to have a considerable effect in reliev- ing me from dispeptic symptoms, with which I had been previously troubled, and also benefitted a chronic inflammation of my eyes. I am stiM subject to an eruption of watery pustules between my fingers, which dry up, and the cuticle peels off." Letter date dJuly, 1815. Many constitutions are but slightly, or not at all, affected by the poison of the Rhus vernLx. This I find to be my own case. After the same exposure, which occasioned the case just detailed, I experienced no ill consequence, except a slight vesicular eruption on the backs of the hands and about the eyes, which disappeared in a short time, without farther inconvenience. The same slight affection I have felt upon several subsequent ex- 108 RHUS VERNIX. posures, particularly when making, from a recent specimen, the drawing which accompanies tlus account. I apprehend that a majority of persons are not liable to the injurious effects of the poisonous su- macs. Among persons residing in the country, exposures must occur yery frequently from the abundance of these shrubs, especially of the Rhus radicans, by roadsides and elsewhere. Very few however, in proportion to the number exposed, have personal experience of their deleterious ef- fects. In those on the contrary, in whom a con- stitutional liability to the poison exists, the disease frequently returns several times during life, not- withstanding the utmost precaution in avoiding its causes. A gentleman residing in the coun- try informed me, that he had been seven times poisoned to the most violent degree. In such constitutions a slight exposure is sufficient to ex- cite the disease. I have known individuals bad- ly poisoned in winter from the wood of the Rhus vernix, accidentally burnt on the fire. Others have made the same observation. Some farther remarks on the poison of these shrubs, and on the treatment of the disease oc- casioned by them, will be made in a future part of this work, under the head of Mhus radicans. POISON SUMACH. 109 Many interesting observations on the proper- ties of these species of Sumach, will be found in an inaugural dissertation, by Dr. Thomas Hors- field of Bethlehem, Pa. a work of much industry and merit. In the New York Medical Repository is an account of a swarm of bees, which, bavins: alisjlit- ed on the branches of the Rhus vernix, were the next day found dead, with their bodies black and swollen. This is a remarkable circumstance. There is certainly no instinctive aversion in these animals for the tree. In the flowering season the blossoms, which are very fragrant, are always thronged with a multitude of winged insects in quest of their honey. The introduction of the juice into the arts will not perhaps take place among us, during the present high price of labour, and the general pre- judice which exists against the shrub. In some fu- ture period, it is probable that a substance, which is found so valuable in the eastern countries, will not be neglected among us. It might safely be procured by persons not subject to the poison, and, with proper precautions, would injure no one during its preparation and use. A pound of the juice in a day might be collected by an individ- ual. When thoroughly dry, it ceases to emit an 110 :rhus vernix. effluvium, and nothing farther is to be apprehend- ed from its effects. BOTANICAL REFERENCES. Rhus vernix Linn^us, Sp, pi. — Aiton, Hort. Kew. i. 366. — MicHAUX, i. 183. — PuRSH, i. 205. — Pennated toxicodendron Eu-is, Phil, trans, abr. xi. passim. American toxicodendron Miller, ibid. — ^Toxicodendron carolinianura foliis pinnatis, &c. Mazeas, ibid. x. 595. — Toxicodendron foliis alatis, fructu rhomboideo, Dill. Elth. 390, t. £92,/. 377. — Arbor Americana alatis foliis, succo lacteo, venenato, Plukenet, j7%f . 1. 145./. 1. MEDICAL REFERENCES. Dudley, Phil, trans, abr. vi. 507. — Sherard, ditto. 508.— Kalm, travels^ i. 77. — Marshall, arbust. 130. — Cutler, Amer, Acad. 427. — Barton, Coll. 24. — Thacher, Disp. 321. — Hor»- riELD, Inaugural JJissertation, PLATE X. Fig. 1. Rhus vernix, with staminijerous flowers. Fig. 2. A staminiferous or barren flower magnifledi. Fig. 3. Stamens and rudiment of a pistil. Fig. 4. .S fertile flower magnifled. Fig. 5. Germ and stigmas. Fig. 6. Thefmit. /v. ^ri. f>/t/// f/t itirr,-/^/r//r- ' • AMERICAN MEDICAL BOTANY. COOTUM MACTJLATUM. Hemlock. FLJITE XL A PLANT bearing the name of Conium^ nrnziov. lias been noted as a poison from remote antiquity. In consequence of tlie power which it possessed when given in sufficient quantities, of destroying life in a certain and almost immediate manner, it was used at Athens as a mode of execution for those condemned to death by the tribunal of Areopagus. Socrates andPhocion were among the distinguished ancients, who suifered death by the agency of this mortal poison. The accounts which have been left respecting it would lead us to believe that its operation was speedy, and unattended with any violent or long protracted suffering. It was not only employed as an instrument of public execu- 114 CONIUM MACULATUM. tions, but was resorted to by those who sought to encounter suicide in its least formidable shape. Among other instances, that of the Cean old men is related by iElian, who when they had become useless to the state, and tu-ed of the infirmities of life ; invited each other to a banquet, and having crowned themselves as in celebration of a joyous festival ; drank the Conium, and terminated their existence together. The description which has been left by Di- oscorides of the Conium, only shews it to have been an umbellate plant, his character of which might apply to many species. The mention made of it by Latin writers under the name of Cicuta are not more satisfactory. Linnseus, in- fluenced by the noxious character of the modern officinal Hemlock, has appropriated to that plant the name of the Grecian species, and most subse- quent botanists have followed liis example. Hal- le r, however, is of opinion that the ancient poison was not procured from this plant, but from the Cicuta virosa L. a poisonous aquatic, much more powerful and violent in its operation than the common Hemlock. Lamarck adopts the opin- ion of Linnaeus, and believes that the Conium ma- culatum was really the Grrecian poison, and that it3 properties were rendered more active by the HEMLOCK. 115 lieat of the climate in which it grew. Guersent supposes that the poisonous draught used bj the Greeks was not the product of a single species, but a compound prepared from several plants. Were it not for the tranquillity and ease which attended death from the ancient hemlock, and which Plato has described with interesting' mmuteness, there would not have been much diffi- culty in supposing the Grecian plant to be the same with that known at the present day. [JVoie H.] It appears that a lai^ge quantity was requisite to insure death. The poison was swallowed in the crude juice, recently expressed from the plant. Of this the draught taken by Phocion was large enough to cost twelve drachmae.^ Socrates was prevented from making a libation of a part of the contents of his fatal cup, by being told that the whole was necessary to produce the consummation of his sen- tence. A large quantity of the modern hemlock might probably have been equally fatal, though with more violent symptoms than those which, if Plato be correct, were experienced hj the Atheni- an philosopher. The plant, represented in our plate, undoubt- edly came to us from Europe. It is now suffi- ciently common in the United States, about road * Plutarch, Life of Phocion. 116 CONIUM MACULATtJM. sides and in waste ground, especially in those parts of the country which have been longest set- tled. It is usually found in bunches, and attains the full height of a man. It flowers from June until the arrival of frost. The very natural order, called Umbellatge by Linnaeus and Umbelliferse by Jussieu, to which tliis plant and the following one belong, is found in the class Pentandria and order Digynia of the Linnsean artificial method. The genus Conium of Linnseus has both general and partial involucres, the latter being halved. The fruit roundish and furrowed. The species maculatum has the fruit un^ armed with the ridges undulated^ Its more complete description is as follows. Boot biennial, somewhat fusiform and generally branched. Stalk round, very smooth, striated, hol- low, jointed, and more or less marked with pur- plish spots. Leaves two or three times pinnate, of a very bright green, with long, sheathing peti- oles inserted on the joints of the stem ; the leafets pinnatifid and toothed. Flowers in terminal umbels, the general involucre with half a dozen - lanceolate, reflected leafets, the partial involucre with three or four situated on the outside. Flow- ers very small, white. Petals five, oval with their HEMLOCK. 117 points inflexed. Stamens five, spreading, about the length of the corolla. Germ inferior. Styles two reflexed outwardly. Fruit roundish-oyal, com- pressed, ribbed, the ribs being transyersely wrin- kled or crenate ; separating into two oblong-hem- ispherical seeds. Hemlock when fresh has a strong nauseous odour and taste. If the green leaves are distilledj the water which collects in the receiver has an in- supportably nauseous taste, while that wliich re- mains in the retort is comparatively insipid. This cu-cumstance, and likewise the fact that the dried leaves become inert by age and exposure, render it probable that the chief medicinal efficacy resides in a volatile portion of the plant. Of the more fixed ingredients of Hemlock, a variety of analyses have been made. The most recent which I have met with is that of Sclirader, who from a thousand grains of the plant obtained the foUoAving substances. Extractive 27.3 — Gummy extract 35.2 — Resin 1.5 — Albumen 3.1 — Green fsecula 8. — He also detected various earthy and alkaline salts. These however are found to vary according to the soil in which the plant grows. The vola- tile portion, which I obtained in water distilled from the leaves, did not exhibit any essential oil, and effected no change in the colour of litmus. It 118 CONIUM MACULATUM. was not altered by sulphate of iron nor acetite of lead. The Coniuni maculatum is a narcotic poison, though not of the most powerful kind. Instances of fatal effects from it have been recorded by Dr. Wat- son m the Pliilosophical Transactions, and by sev- eral other writers. A remarkable case of this sort, which occurred in Spain, is cited by Orfila in his Traid des poisons. But there is scarcely any narcotic plant respecting the character of which such various and opposite testimony has been ad- duced by medical writers. Even the experiments of the same individual are apt to present different results from its use, unless great care be taken in the collection and preparation of the medicine. The truth is, the plant varies exceedingly at differ- ent ages, and in different places of growth, and the strength of its preparations is greatly influenced by external cu'cumstances. When the green leaves of a mature plant which has grown in the sun, or the juice of these leaves, either crude, or properly inspissated, is taken into the stomach ; the following symptoms, if the quantity has been sufficient, will rarely fail to take place ; viz. a dizziness of the head and nausea of the stomach, a sense of fullness in the eyes and diminished power of vision, together with HEMLOCK. iiQ a general faintness or muscular weakness of the whole body. These sensations usually begin in the course of half an hour. If the dose has"" been moderate, they will for the most part disappeai- in the course of half a day, and seldom continue beyond twenty four hours. Larger doses occasion more severe symptoms, as it happens with other narcotics. The idiosyncrasies of different persons render them variously susceptible of the action of Hem- lock. Some are but slightly affected by a quanti- tj, which would prove dangerous to others. The Hemlock has been for many years a sub- ject of attention with physicians, and has been found a remedy of importance in several diseases. It would occupy a volume to state the whole of the evidences which have been given for and against its use. I shall only mention those com. plaints in which it has been most employed, and particularly in this country. In Jaundice— Dr. Fisher, President of the Massachusetts Medical Society, in his paper on the narcotic vegetables, bears unequivocal testimony in favour of the efficacy of Hemlock in tliis com. plaint. He was first induced to employ it with a view to its relaxing effect in facilitating the passage of biliary calculi. Afterwards it was 16 ISt) CONIUM MACULATUjM. gh en by him to many icteric patients, and witli the exception of three complicated cases, it never failed in his hands or witliin liis knowledge to re- moYe the disease. Dr. Jackson, Professor of the Theory and Practice of Physic in our University, informs me that he has found it of great utility in jaundice, and that except in one or two instances, it has always effected the cure of those cases, which proved susceptible of relief from any medi- cine. I have repeatedl}^ employed it in the same complaint with indubitable advantage. The dose should be gradually increased until its effects are distinctly felt in the head and stomach. This inconvenience is temporary, and will be preferred by most patients to the evil of a mercurial ptya- lism. The yellowness of the skin and eyes, in fa- vourable cases, begins to disappear at an early pe- riod, frequently by the second day. — The forego- ing practice in jaundice is not new, having been employed in Sweden by Eosenstein, and in other places. In tic doloureux. In a discourse on this painful disease by Dr. Jackson, }>ublished in the Kew England Journal, Yol. II. a number of cases are detailed, in which perfect relief was afforded by the Hemlock given in large doses, and rapidly in- creased until a decided effect upon the system was HEMLOCK. i2i felt. Dr. Jackson recommends to begin with a single gTain of the extract, and to increase to five grains for the second or thu'd dose ; afterwards to add five grains to every dose until a full effect is felt on the system. In this discourse he cites the experience of Dr. Fothergill, who had employed the Conium successfully in several cases of tliis disease under a different name. It appears also that some French physicians, whose writings 1 have not seen, as Chaussier and Dumeril, have con- firmed the success of our plant in tic dolom^eux. It must he confessed however, although the Hem- lock is more successful in this complaint than per- haps any internal medicine, which has been tried ; yet there are cases of such obstinacy, as wholly to baffle the powers of its operation. In scliirrus and cancer. Since the time of Storck, tliis medicine has been long and abundant-. ly tried, but without any increase of reputation. The experience of modern physicians, and amono- others of M. Alibert, who tried it in more than a hundred cases in the hospital of St. Louis, have pretty well established the fact, that it is wholly in- capable of curing either scliirrus or cancer of the confirmed and genuine kind. It is however still ad- ministered, rather with a view to its anotlyne and palliative efiect, than any expectation of radical ben- i22 CONIUMMACULATUM. efit. In tills way its external use is sometimes serviceable. In old syphilitic affections, it is occasionally useful. It lias been recommended in hooping cough, but it is not a perfectly safe medicine for cliildren, owing to the difficulty ofascertaining when its constitutional effects take place in them. — I am informed on the best medical authority, that it is of great use in some cases of hemicrania, which are not regularly intermittent. The most common form of preserving the Hemlock for use, as well as the most convenient for its exhibition, is that of the inspissated juice or ex- tract. It is well known however, that the extracts kept in our shops differ materially in their strength, so that in beginning from a new parcel, the physi- cian can seldom predict the degree of operation of his jSrst doses. In some instances very great quan- tities have been taken without the least effect. The extract is apt to prove inert when the plant is gathered too young, when the evaporation is con- ducted with too much heat, when a decoction of the dried plant has been evaporated instead of the fresh leaves, and lastly when the extract itself has become old. To give the extract its due strength, the plant should be collected at full maturity, while in flower, or in fruit provided it remains green, and HEMLOCK. 123 tliejiiice or the decoction should be evaporated at the heat of boiling salt water. The stock should be renewed every year. A suitable dose for commence, ment is from one to five grains. This may be in- creased at every time of taking it, until its constitu- tional effects are felt. In beginning the use of a new parcel, more caution is requisite at first, than after its strength has been tested. The ^thusa cynapium, an umbellate plant very common in Boston, has sometimes been mis- taken for Hemlock, wliich it considerably resem- bles. It is a smaller plant, with its stalk not spot- ted. It differs also in having no general involucre, wliile its partial one is very long. BOTANICAL REFERENCES. Conium Maculatum, LiiofiEus. Sp. PZ.— AVoodviile, t. 22.— Curtis, Fl. Loud. i. 1 7 — Smith, Engl. Bot. 1. 1191.— Pttrsh, i. 195.— Ciciita vulgaris, Morisost, Umb. t. 6 — Parklyson, Theatr. 933 — Ciciita major, Lamarck, Encijdopedie Methodique Ci- cutaria Tuigaris, Cittsitts, Hist. 200. MEDICAL REFERENCES. ^ Murray, Apparatus medicaminum, i. 322.— Cuilek, Mat. Med. ii. 263.— FoTHERGTLt, Med. Obs. iii. 400.— Hu.vter on the ve- nereal, 108, 175, 199, 247, &c.— Home, Jlnnals Med. iii. 66.— But- TER, Med. Comment, i. 373.— Fisher, Mem. Mas. Soc. i.— Jack- so^r, JX". Engl. Journ. ii. 105— Guersent. Diet. Sciences Medi- rales, v. 208.— Orfila, Toxicologie, ill. 279, &c. &c. ^c. 124} CONIUai MACULATUM. PLATE XI. Fig. 1. A branch of Coiiiummaculatum. Fig. 2. Flower magnified. Fig. 3. Fruit magnified. J'/..W . CICUTA MACULATA. American Hemlock. PLATE XU, J-T is a rule sanctioned by the observations of medical botanists, that umbelliferous plants, which grow in or about the water, are of a poisonous na- ture. This rule will generally be found correct, al- though it has exceptions. As far as aquatic plants of this natural order have been examined, theu* properties, in a great majority of instances, have been found, more or less of a deleterious kind. The Clcuta virosa of Europe is a highly poisonous plant, possessing such formidable activity that its internal use is hardly attempted in medicine. An American species, the Cicuta maculata, the sub- ject of this article, is very closely allied in its bo- tanical habit to the European plant, and was equal- ly deserving of suspicion from its appearance, al- though the public were not generally aware of its true character. Witliin a few years past, several 126 CICUTA MACULATA. instances have been brought to light of fatal ef- fects ensuing from tliis plant being incautiously eaten by cliildren. It is therefore necessary that the species should be suitably designated, that a source of so much danger may be known and avoided. The Cicuta maculata, to which I have applied the name of American Hemlock, not having heard any common appellation except that of Snakeweed, inhabits wet meadows and banks, from the northern to the southern limits of the United States, flowering in July and August. It is so fre- quently cut with hay, among wliich it often grows in lai'ge quantities, that we might expect to see its deleterious properties operating on domestic cat- tle, were it not that their bodies are probably less susceptible of its poison than ours. The Euro- pean Cicuta, above mentioned, is higlily noxious to man, and to some domestic animals, yet goats and sheep eat it with impunity. The genus Cicuta differs from other genera of umbellate plants in having no general involu- cre, a short, partial involucre, and a fruit which is nearly orbicular^ compressed and furrowed.^ * This description of the fruit agrees with the present species and also with Cicuta bulbifera, a smaller species not uncommon about Boston. The Cicuta virosa of Europe I have never seen. AMERICAN HEMLOCK. 127 The species iiiaciilata has a fascicled root and oblong leaves with mucronate serratures. The class and orders are as in the last article. This plant is so remarkable for the form of its root, that had not the name of maculata been con- firmed to me by the best authorities, I shonld have thought that of fasciciilata to be greatly pre- ferable. Tlus root is composed of a number of large, oblong, fleshy tubers, diverging from the base of the stem, and frequently being found of the size and length of the finger. The root is pe- rennial, and has a strong, penetrating smell and taste. In various parts of the bark it contains distinct cells or cavities, which are filled with a yellowish resinous juice. The plant is from three to six feet high. Its stem is smooth, branched at top, hollow, jointed, striated, and commonly of a purple colour, except when the plant grows in the shade, in which case it is green. The leaves are compound, the largest being about three times pin- nate, the uppermost only ternate. Most of the pe» tioles are furnished with long obtuse stipules, which clasp the stem with theii* base. Leafets ob- long acuminate, serrate, the serratures very acute or mucronated. The veins end in the notches, and not at the points of the serratures. The flowers grow in umbels of a middling size, without a general invo- 17 128 CICUTA MACULATA. lucre. The partial umbels are furnished with iiir. volucres of very short, narrow, acute leafets. The distinctness or sepai^ation of these umbels charac- terizes this plant at a distance among other plants of its kind, whose umbels are more crowded. Ca- lyx of five very minute segments. Petals five, white, obovate with inflected points. Fruit nearly orbicular, compressed, ten furrowed, crowned at top, and separating into two semicircular seeds. The fleshy root of the Cicuta maculata, when pressed, emits from its divided extremities a viscid yellowish juice of a strong penetrating taste. This juice dissolves in alcohol, from wliich it is precipi- tated by water. When distilled, a thick volatile oil collects in the receiver in the form of a film upon the surface of the water. The remainder of the juice yields a resin of a dark orange colour, fusible and inflammable. The decoction of the root affords a pearl coloured fluid, not very sensi- ble to the tests of mucus, fsecula, tannin or ex- tractive. In August 1814, an account was sent to Bos- ton by Br. Stockbridge of Bath (Maine) of the ef- fect protluced on three boys by eating a poisonous root, which they had dug up, supposing it to be- long to the plant called " Life of man." One of them was siezed with violent convulsions, frothed AMERICAN HEMLOCK. ^gg at the mouth, and died in an hour and a half. The other two were affected with vomitmg, stupor, dil- atation of the pupil, great paleness and universal distress ; which symptoms disappeared m one in twenty four, and in the other in thirty six hours. It was supposed that the first boy had swallowed about a drachm of the root, and the others about half that quantity. A specimen of the plant was sent to me at the same time with the account, and proved to be the Cicuta maculata. Dr. Stock- bridge's letter, wliich was published in the K^ew England Journal, contains two other cases of the effect of tliis root, in one of wliich it proved fatal. Shortly after the publication of the above facts, an article appeared in the New York Medical Re-' pository, containing an account by Dr. Ely of Butchess county, of the effects of an unknown poisonous root, supposed to be the white helle. bore. Three small boys, who had gone into a meadow in search of sweet flag root, had dug up and eaten another root hj mistake. Two of them died in convulsions in about an hour after they had swallowed it. They discharged much blood and froth from the mouth and nose ; then- eyes were fixed, with the pupils dilated, and a rapid motion of the eye lids. The tlm^d boy vomited, and recovered. When taken to the place the next 130 CICUTA MACULATA. day, he pointed out the spot where they had dug the root, and where a considerable quantity of it remamed. Some of the root was planted by Dr. Mitcliill in the ]>few York Hospital garden, where it vegetated and produced flowers and fruit. It turned out to be the Cicuta maculata of Linnseus. In the same article, is a letter from Dr. Muhlen- berg, stating that he had received specimens from Savannah and from West Pennsylvania, where it had destroyed several persons, who ate it, by mis- take for angelica. All the specimens were simi- lar, so that there could be no doubt of the identity of the plant. In the same letter. Dr. Muhlenberg remarks, that he had reason to believe that the poi- sonous quality of the root is altered by cultivation in a dry soil. The foregoing facts are sufficient to establish the poisonous character of the plant under consid- eration. They may also serve to shew the im- portance of accm*ate descriptions and faithful en- gravings of noxious vegetables, wliicli may enable even unlearned observers to distinguish them at sight. There can be little doubt that cases, like those above described, have occurred iii repeated instances, which have never met the l^ublic eye. Perhaps also from an ignorance of the real cause of the s^^nptoms, the proper remedies have been AMERICAN HEMLOCK. 131 neglected. The plant is extremely common in many parts of the United States, and I believe its true character is not generally suspected. A yery respectable physician informed me, that it was used in his vicinity as a gargle for sore tlii'oats, by people unsuspicious of its qualities. Since the discovery of its narcotic properties, the Cicuta has been used in small doses, as a sub- stitute for the conium, by one or two practitioners in tills place. Its effects were very analogous to those of the true hemlock, as far as they were observed, but more powerful. A primary symptom, wliich attended a large dose, was nausea and vomiting. The treatment of persons poisoned by this plant, as in the case of other narcotics, should pri- marily consist in a thorough evacuation of the stom- ach. As there commonly exists a spontaneous tendency to vomit, occasioned by the poison itself, this should be assisted by mechanical means, by irritating the tliroat with the finger, or with a feath- er. Of emetics, the sulphate of zinc is to be pre- ferred, on account of its speetly operation. Cas- tor oil or infusion of senna, shoukl be given as soon as vomiting has taken place. The vegeta])le acids, such as lemon juice or vinegar, have a neu- tralizing influence on the narcotic, and are there- fore useful. Stron^^' coffee and tea are the best an- iS2 CICUTA MACULATA. tidotes for the stupor, and should be promptly ad- ministered. In violent cases, bloodletting should be resorted to. As most narcotic poisons act by destroying the functions of the brain, respu'ation being suspended, because it is under the influence of that organ ; Mr. Brodie is of opinion, that in some cases, life might be preserved by keeping up ai^tificial respu^ation, after death has apparently taken place. BOTANICAL REFERENCES. Cicuta maculata. Linnjbus Sp.pl. — ^Puesh, i 195. — ^gopo- dium foliis lanceolatis, acuminatis, serratis. Gnoivovius, Virgt 32. — Angelica Caiibeearum elatior, olusatri folio ; flore albo 5 seminibus kiteis, striatis, cumiui odore et sapore ? Pxukenet, Mm. 31, Phyt. t. 76, f. 1. MEDICAL REFERENCES. ScHffiPF, 36. — Bart. Coll. 18, 46. — Stockbeidge, JVetv Engl. Journal, iii. 334. Mitchill, EtT and Muhlenberg, Med. Repository, xvii. 303. ri.jcJJi. Sr^ ^^t€iCrrili4.y trytrf/oiffi KALMIA LATIFOLIA. Mountain laurel. PLATE xm. A HE Swedish botanist, Peter Kalm, a pupil of Linn^us, who travelled in North America in 1748 — 9, has had the honor of giving name to one of the most elegant genera of flowering shrubs wliich our continent produces. The genus named Kalmia hj Linnaeus, includes several species, of singular beauty, among which the Mountain lau- rel is much the largest and most elegant, as well as the one whose properties have received most atten- tion. Its occurrence in the United States is very frequent, and its common appellations of course va- rious. The names of Laurel, Lambkill, Ivy, Spoon- wood, and Calico bush, it seems, are applied to it in various parts of the country. This slu'ub grows in the southern parts of New Hampshire, and is oc- casionally met with throughout Massachusetts. In the Middle States it becomes more frequent, 134 KALMIA LATIFOLIA. and it is said to extend near to the southern lim- its of the Union. Michaiix, in his account of the forest trees, states, that it is particularly abundant through the whole range of Allegany mountains, upon the borders and near the sources of rivers. It gradually diminishes however on both sides as these rivers approach to the sea, or to then* con- fluence with the great western streams. The botanical character of the genus consists in a jive parted calyoc^ a hy po crater if orm corolla^ containing ten depressions in its border, in which the anthers are lodged ; a capsule jive celled. The specific chai*acter is, that the leaves are scattered, petioled, oval and smooth ; the coryjnbs terminal, viscid and pubescent. Class Lecandria, order Monogynia. Katui^l orders Bicornes, Linn. Mhododendra, Juss. The height of the Kalmia latifolia is generally that of a shiaib, sometimes however attaining to the altitude of a small tree. Its leaves are ev- ergreen, coriaceous, very smooth, with the under side somewhat palest. Their form is oval, acute and entire ; their insertion by scattered petioles, on the sides and extremities of the branches. The flowers vary from wliite to red; they grow in termi- nal corymbs, simple or compound with opposite branches, and made up of slender peduncles. These Mountain laurel. 13S^ are invested with a glutinous pubescence, and sup- ported at base by oyate, acuminate bractes. The calyx is small, five parted, persistent, with oval, a- cute segments. The corolla is nionopetalous, with a cylindrical tube, a spreading disc, and an erect, five cleft margin. At the circumference of the disc on the inside, are ten depressions or pits, accom- panied with corresponding prominences on the outside. In these depressions the anthers are found lodged at the time when the flower expands. The stamens originate from the base of the corol- la, and bend outwardly, so as to lotlge their an- thers in the cells of the corolla. From tliis con- finement they liberate themselves during the pe- riod of flowering and strike against the sides of the stigma. The germ is roundish, the style lon- ger than the corolla and declined, the stigma ob- tuse. Capsule roundish, depressed^ five ceiled and five valved, with numerous small seeds. I have examined chemically the leaves of the ILalmia, gathered at the time the slii^ub'' was in fruit. The following constituent principles' were found to exist in them. 1. Vegetable mucus. This exists in large quan- tities, and is dissolved in water both by infusion and decoction, rendering it extremely muciia&i- Eous or ropy. When alcohol is added to this so- 136 KALMIA LATIFOLIA. lution, the mucus separates in the form of a floe- culent coagukim, which is tough and stringy, and on di'jing has a brownish colour. When chewed, it soon fills the mouth with mucilage. Silicated potash rendered the upper stratum of the liquid dark and opaque, but without any pre- cipitate like that which takes place in the mucilage of gum. 2, Tannin. This is readily thi^own down from the decoction and tincture by gelatin. The sul- phate of iron strikes with it a very black colour. 3. Resin. Tliis also exists plentifully. It communicates to alcohol a reddish colour, and is instantly precipitated from it by water. When obtained pure, it is of a reddish cast, fusible, in- flammable and moderately bitter. I have not detected any extractive, properly so called, in these leaves. When the muriate of tin is added to the decoction, it separates a very copious yellow precipitate. Tliis however is ow- ing to the mucus. If alcohol be first added to the decoction, and the coagulum which it forms with- drawn ; the fluid no longer gives a precipitate with muriate of tin, although it readily yields one to gelatin. Distillation with w ater affords a mild fluid with little taste or odour. MOUNTAIN LAUREL. 137 The Kalmia latifolia, together with some oth- er species of its genus, has long had the reputa- tion, in various parts of the country, of heing poi- sonous to certain domestic animals. Catesby says of it, that "d«er feed on its green leayes with im- punity ; yet when cattle and sheep, by severe win- ters deprived of better food, feed on the leaves of this plant, a great many of them die annually." Kalm, the Swedish traveller, who gave name to this genus, says of Kalmia latifolia, " The leaves are poison to some animals, and food for others ; experience has taught the people, that when sheep eat of these leaves, they either die immediately, or fall very sick, and recover with great difficulty. The young and more tender sheep are killed by a small portion, but the older ones can bear a stron- ger dose. Yet this food will likewise prove mor» tal to them, if they take too much of it. The same noxious effect it shews in regard to calves which eat too much of the leaves ; the}^ either dicj or do not recover easily. I can remember that in the year 1748 some calves ate of the leaves ; they fell very sick, swelled, foamed at the mouth and could hardly stand ; however, they were cured by giving them gunpowder and other medicines. The sheep are most exposed to be tempted with these leaves in winter, for after having been kept in sta- 138 KALMIA LATIFOLIA. bles for some months, tliey are greedy of all greens^ especially if the snow still lies upon the ground, and therefore the green but poisonous leaves of the Kalmia are to them very tempting. Horses, oxen and cows, which have eaten them, have like- wise been very ill after the meal, and though none of them ever died of eating these leaves, yet most people believed, that if they took too great a por- tion of them, death would certainly be the result." " On the other hand, the leaves of the Kalmia are the food of stags, when the snow covers the ground and hides all other provisions from them. There- fore, if they be shot in winter, their bowels are found filled with these leaves, and it is very extra- ordinary, that if those bowels are given to dogs, they become quite stupid, and, as it were, intoxi- cated, and often fall so sick, that they seem to be at the point of death ; but the people who have eaten the venison have not felt the least indisposi- tion." — Travels in JS'^orth America, vol. i. There is a common belief, that the flesh of the American Pheasant or Partridge is at certain times imbued with a poisonous quality. This cii'cumstance has been attributed (I know not with what evidence) to their feeding in winter upon the buds of the Kalmia. Mr. Wilson, the ornitholo- gist, informs us, that he has sometimes found the MOUNTAIN LAUREL. 139 crops of these birds distended almost entii^ely with laurel buds ; but that he has eaten freely of the flesh of these very bu-ds, without any ill conse- quence whatever. On the human system, the Kalmia has been also said to manifest a deleterious influence. The late Professor Barton has atkluced some evidences of its noxious character.* He states that the In- dians make use of a decoction of the leaves to de- stroy themselves. In an Inaugural Dissertation on two species of Kalmia, the latifolia and angus- tifolia, by Dr. G. K. Thomas, we are told that the leaves of these shrubs possess a decidedly nai'cotic property. I have not recently seen Dr. Thomas' Dissertation, and therefore quote from memory and from extracts. From his experiments howev- er it appeared, that a very small quantity was suffi- cient to produce sensible inconvenience. Thu*ty drops of a strong decoction, given six times a day, are said to have occasioned so much vertigo, as to render it necessary to diminish the frequency of its exhibition. Fi-om my own experience, I am not disposed to tliink very liighly of the narcotic power of the * Dr. Barton states, that a few drops of the tincture poured upon the body of a large and vigorous rattlesnake, killed the reptile in a very short time. 140 KALMIA LATIFOLIA. Kalmia. I have repeatedly chewed and swallowed agreenleaf of the largest size, without perceiving the least effect in consequence. I have also seen the powder, freshly made from leaves recently dri- ed, taken in doses of from ten to twenty grainSj without any subsequent inconvenience or percep- tible effect. The taste of these leaves is perfectly mild and mucilaginous, being less disagreeable than that of most of our common forest leaves. I am inclined to believe that the noxious eifect of the Kalmia upon young grazing animals may be in some measure attributed to its indigestible quality, owing to the quantity of resin contained in the leaves. An ointment made of the powdered leaves has been recommended in tinea capitis and some oth- er cutaneous affections. I have seen an eruption, very much resembling psora, removed by it. The wood of the Kalmia is hard and dense, ap- proaching in its character to that of box. It is much used for the handles of mechanics' tools, ^c. and it has even been employed as a material for musical instruments. As an ornamental shrub, this species stands in the highest rank, and by the fre- quency of its growth and the brilliancy of its flow- ers, it contributes in a great degree to the ele- gance of the natural scenery in those mountains MOUNTAIN LAUREL. I4I and woods, which it inhabits. When cultivated in gardens, it requires a soil wliicli is somewhat moist, and a shady or northern aspect. BOTANICAL REFERENCES. Kalmia latifolia, Liiv. Sp. ^Z.— Curtis, Bot. Mag. t. 175.— MicHAux/. fibres forestiers, iii. 147", t. 5.— Pursh i. 296.— Cha- msedaphne foliis tini, &c.— Catesby, Carolina, i'ut. 98.— Ledum floribus buUatis. &c. Treav, t. 38.— Cistus cham^rhododendros, &C. PXIIKENET, Phijt. t. 379,/. 6. MEDICAL REFERENCES. KAJ.M, travels, I 335, &c.— Bart. Coll. i. 18, 48; ii. 2$. Thacher, Lisp. 247. — Thomas, Inaugural dissertation. PLATE XIIL Fig. 1. Branches of Kalmia latifolia with flowers and fruit. Fig. 2. Stamens. Fig. 3. Calyx and instil. SPIGELIA MARILANDICA. Carolina Pink root. PLATE XIV, We are told by different writers, that this fine plant is a native of all the southern states from Pennsylvania to Georgia and Louisiana, growing in rich soils, especially about the borders of woods. It does not bear the severity of a nor- thern winter. For my living specimens I was in- debted to my excellent and learned friend, the late Dr. James Macbride, of Charleston, S. C. The genus Spigelia has a funnel shaped corol- la and a capsule, which is double, two celled and many seeded. The species Marilandica is peren- nial, with a simple stem and opposite leaves. Class PerifantlWft; order Monogynia, Natural orders Stellatce, Lin. Gentianm, Juss. The root of the Spigelia Marilandica is peren- nial, with many fibrous branches. The stalks proceed several from a root 5 they are simple pij^n CAROLINA PINK ROOT. 143 four sided and nearly smooth. Leaves opposite, sessile, ovate, acuminate, entire, smooth, with the mai^^ins and veins sometimes puhescent. The stalk commonly terminates in a simple one-sided raceme of flowers, although I have seen luxuriant specimens with two. The peduncles are extreme- ly short, so that the raceme may without impro- priety be denominated a spike. Calyx persistent, with five linear-subulate, finely serrulate leaves, which are reflexed in the ripe fruit. Corolla five times as long as the calyx, scarlet or crimson without, orange coloured within, the tube inflated and angular at top, the border divided into five acute, spreading segments. Stamens very short, inserted into the mouth of the corolla between the segments ; anthers oblong-heart shaped. Germ small, superior, ovate. Style longer than the co- rolla, jointed near its base and bearded at the ex- tremity. Capsule double, consisting of two, co- hering, one celled, globular portions, seated on a common receptacle. The Spigelia is a mucilaginous plant, with a mild and not very disagreeable taste. The infu- sion and decoction of the root and leaves aiford a flocculent precipitate with alcohol. They are discoloured but not precipitated by silicated pot- ash. They have little sensibility to gelatin, al- 19 144 SPIGELIA MARILANDICA. tliougli the tincture is made turbid by it. After the decoction was filtrated from the mucus, which had been coagulated by alcohol, it gave a precipitate with nitrate of mercury, but none with muriate of tin. Sulphate of iron caused a dark green precip- itate from the decoction, and but little change in the tincture. No distinct evidence of resin pre- sented itself. A substance which may perhaps be considered a variety of extractive matter, ap- pears to exist in this plant, as the tincture was affected in nearly the same manner by the salts of tin and mercury above mentioned, as the fil- trated decoction. Water may be considered an adequate solvent for the chief proximate principles of this plant. The medicinal reputation of the Spigelia is founded on the powers which it is supposed to possess as a vermifuge. This reputation is now so generally established, that the plant has be- come a considerable article of commerce to vari- ous parts of the world, from our southern states. Tliis is a sufiicient evidence, that the medicine has, to a certain extent, satisfied public expecta- tion, and obtained the sanction of practitioners. But beyond tliis, it is difficult to speak confident- ly on the subject. The Spigelia belongs to a class of medicines, which are frequently prescrib- CAROLINA PINK ROOT. 145 ed, without positive proof of the existence of the cause which they are intended to remove ; which often fail altogether in the hands of the most suc- cessful practitioners ; which frequently succeed merely because they are hacked with medicines of a more active class ; and whose apparent suc- cess is sometimes the consequence solely of a dis- eased state of the body.* Our plant is however entitled to trial, especially where it can be obtain- ed fresh, and in full strength. A physician of the southern states, for whose opinion I have much respect, Dr. ISTorcom of Edenton, N. C. inform- ed me some years since, that the Spigelia was * From the list of equivocal anthelmintics, I would except those which have a cathartic operation, also a number of mineral origin. But I am fully persuaded, that many reputed vermifuges have en- joyed a reputation which they do not deserve. The Dolichos pruriens has received the commendations of practitioners and medical writers, on the presumption that its spiculae exert the same stimulant effect on the bodies of worms in the alimentary canal, that they do on the nu- man skin externally. I was long ago inclined to doubt the power of these spiculse to withstand the digestive process of the stomach. My suspicions were confirmed upon finding that simple macera^ lion in warm water for an nour, dissolves their virus, and renders them incapable of producing their usual stimulus of itching, fwhen applied to the skin. Some late experiments by my pupil, Dr. Chan- dler, have shewn that the gastric juice destroys their activity in the same manner. It is not necessary in this place to revert to the Fern root of Mad- ame Nouffer, and various other exploded anthelmintics of its kind. 146 SPIGELIA MARILANDICA. most active when recently dried, and tliat its efficacy was always impaii'ed by keeping more than six months. Dr. Garden had previously made observations somewhat similar. If tliis be the case, we may account for its failures in the hands of those who obtain it at a distance when half a dozen years old. Drs. Lining, Garden, and Chalmers of Caroli- na, are the writers who first introduced the Spi- gelia to notice, and who have spoken most une- quivocally in its praise. Each of these physi- cians has represented it as an anthelmintic of superior efficacy. It appears that under certain circumstances, it is capable of operating as a ca- thartic, and that in these instances, the most ad- vantage has been experienced from it. Dr. Gar- den says, that he had given it in hundreds of cases, and that he " never found it do much good except when it proved gently purgative." As the action of the Spigelia upon the bowels is quite uncfertain, most practitioners either unite, or fol- low it with calomel or some purgative medicine. We are told that the pink root, when in its most active state, if given m large quantities, indu- ces narcotic symptoms, such as stupor, headach, dilated pupil, ^c. Dr. H. Thompson, who took large doses of the root to try its effect on himself. CAROLINA PINK ROOT. 14^ found that it produced an increased quickness of the pulse, drowsiness, flushing of the face and stiifness of the eyelids. Dr. Chalmers attributes to its too free use the cases of two childi'en, who died in convulsions. Dr. Macbride informs us that its narcotic effects are seldom or never at- tended with danger, and that some physicians consider them an evidence of the favorable opera- tion of the medicine. The opinion that tliis effect is owing to the root of some deleterious plant taken up with the Spigelia, seems to be void of foundation. As in most other perennial plants, the root of the Spigelia possesses a greater share of activity than the herb. Of this root ten grains may be given in powder to a cliild four years old, twenty to one which is seven, and a di-achm to an adult. If no inconvenience ensue, it may be repeated two or three times a day. If the infusion is prefer- red, an ounce of the root may be infused in a pint of water, and half the quantity taken by an adult or one or two spoonfuls by a cliild. BOTAISICAL REFERENCES. Spigelia Marilandica, Liior. Sp, ^jZ.^Cfrtis, Bot. Mag. t. 80.— WooDviiXE, ii. t. 105.— Waxter, Flou Car. 92 -Mi- cHAux, i, 147.— PuESH, i, 139 — EiiioTT, i. 236.— Lonlcera 148 SPIGELIA MARILANDICA. spicis terminalibus, &c. Gronov. Virg, SO. — ^Periclymeni Vir- giniani flore cocoineo planta Marilandica, &c. Catesby, ii. U 78. MEDICAL REFERENCES. Chaimers, 071 the weather and diseases of South Carolina) i. 67. — Lining, Essay Sf phys. and lit, i. 436. Garden, ditto, iii. 145.— Home, Clin, exper, 420. — Murray, .ij)p. Med. i. 548— Macbride, in Elliott's Car. 237. — Thompson, Inaug. JHss. PLATE XIV. Fig. 1. Spigelia Marilandica. Fig. 2. The capsule with the reflected calyx. Fig. 5. Corolla opened. FJ.n'. ASARUM CAIS^ADENSE. Canada Snake root. Wild ginger. PLATE XV. A HE properties of this mild aromatic have been so far misconceived, probably from its re- lation to an European species, that it would be improper in a work of this kind, to pass over it without notice of its real character. It affords a striking exception to the rule, that botanical affin- ities are capable of indicating the medicinal qualities of vegetables. This plant in its effect on the human system, is widely different from the European asarabacca, although it approaches it so neai'ly in its form, that Michaux styles it " vix dis- tinctum ab Europseo." The As arum Canadense grows in old woods and mountainous tracts from Canada to Cai^olina. It is one of the humblest plants, presenting only two leaves with their stalks, which appear to con- stitute the whole of the plant above the ground. 150 ASARUM CANADENSE. On plucking the plant, the two leaves are found connected below, with an obscui^e flower in their fork, wliich had rested on the surface of the ground, or been buried under the decayed leaves and sod. Its flowering time is from May to July. Tliis plant, from the number of its stamens, is placed by Linnseus and Michaux in the class Bodecandria. Pursh, who has omitted this class in his Flora, has transferred the Asarums to Gy- nandria, from the cu^cumstance that the stamens are inserted on the germ. Tliis place however is not better suited to the As arum, than to a multi- tude of other plants whose germ is inferior. Linnseus' natural order for this plant is Sar- mentacece and Jussieu's Jiristolochice. Generic character. Calyoo three or four cleft, superior; corolla none; anthers growing to the middle of the filaments. Capsule coriaceous, crowned. Specific character. Leaves two, reniform ; calyoc ivoolly, cleft to the base; its segments spreading at top. The root of the Asarum is creeping, fleshy, and somewhat jointed. Leaves kidney shaped, pubescent on both sides, with long, round, haii'y petioles. Flower solitary, growing from the fork of the stem, on a pendulous hairy peduncle. Ca- WILD GINGER. 151 lyx very liaiiy or woolly, consisting of three broad, concave leafets, which are mostly of a brownish or dull purple on the inside at top and bottom, and terminated by a long, spreading, inflected point, with reflexed sides. The colour varies greatly according to the amount of light which the plant enjoys, being sometimes nearly green. Stamens twelve, inserted on the germ at a dis- tance from the calyx, the alternate ones longer. Anthers growing to the filaments below theu^ ex- tremity, l^ear the divisions of the calyx are three sliort, curved, filamentary substances, which may perhaps be called nectaries. Germ mferior, somewhat hexagonal, marked at top inside with a dark red line ; style conical, striate, parted at top into six recurved, radiating stigmas. The root of the As arum has an agreeable aro- matic taste, which is intermediate between that of ginger and the aristolochia serpentaria. This quality has given it the names of Wild ginger and Snake root in different sections of the country. The name ColVsfoot is also applied to it. The chemical trials, to which I have subjected the root, bring to view the following substances: — 1. A light coloured, pungent, volatile oil, possess- ing the characteristic taste and smell of the plant in a high degree. 2. A resin, which is of a red- 20 152 ASARUM CANADENSE. dish colour and very bitter. These two constitu- ents communicate to alcohol the active properties of the plant. 3. Fcecula. 4. A gummy mucus. Tliese exist in such quantities as to impede the filtration of the decoction. Astringency hardly exists in tliis root, as a gelatinous solution gave no evidence of tannin, and the sulphate of iron pro- duced a green colour hardly bordering on black. It has been asserted, and the statement copied from one book to another, that the Asarum Cana- dense is a powerful emetic. I presume that sub- sequent writers have taken their opinion from Cornutus, who, in his plants of Canada, informs us, that two spoonfuls of the juice of the leaves of the Asarum, (meaning the European plant, rather than the American,) ai^e found to evacuate the stomach powerfully. I can hardly doubt, that if such an operation has really been produced from the Canadian species, it must have taken place in irritable stomachs, to whom two spoonfuls of any crude vegetable juice would have proved emetic. Having seen the root of tliis plant used in the country in considerable quantities as a sudorific, I was long since induced to doubt its emetic power. Subsequent experience has satis- fied me that the freshly powdered root, given to the extent of half a drachm, and probably in still WILD GINGER. j_^^ larger quantity, excites no yomiting nor even nausea. Still however the plant deserves not to he dis- carded from use. The aromatic flavour of the root is more agreeable than that of the aristolochia serpentaria, which article it seems to resemble in its medicinal powers. Several country prac- titioners, who have employed it, have spoken to me favourably of its effect, as a warm stimulant and diaphoretic. As a substitute for ginger, in common domestic use, I know of no indigenous article wliich promises so fairly as tliis. Alcohol is the proper solvent for the active properties of this plant. The tincture has a dark red colour, and a highly concentrated taste of the root. BOTANICAL REFERENCES. Asarum Canadense, hix. Sp. pl.—MicuAvx, i. £79 —Puksh 11. 596.-Asarumfoliisreniformibus,mucronatis, binis, GrJz.o' vius, 72.— Asaron Canadense, Corl^utus, Canad, 24, t 25 — Asaron Americanum, Parkinson, theatr. 266. MEDICAL REFERENCES. ScHffiPF, 72.— Bart. coll. 26, 48— Coxe, Disp. 568. 154 AS ARUM CANADENSE. PLATE XV. Fig. 1. Asanmi Canadense. Fig. 2. The germ with the stamens and nectareousJilaments» Fig. 3. ►^ petal. Fig. 4. ^ stamen a little magnified. Fig. 5, ^^2/ie and stigmas magnijied^ p/^rn IRIS VERSICOLOE. Blue Flag, or Flower de luce, PLATE XVI. In the Hortus Elthaiiiensis, published by John J. Dillenius in 1732? there are figures of two plants under the name of " Iris Americana versi- color," the one with an entire, the other with a crenate style. To one of these, the plant repre- sented in our plate apparently belongs. This plant however is so subject to variation in the colour of its flowers, the crenatures and direction of its stigmas, ^c. that it has received from differ- ent botanists dissimilar names. The Linmean characters of Iris versicolor and Virginica are hardly sufficient to distinguish them from each other. Our plant is the Iris versicolor of Muh- lenburgh's catalogue, by his own declaration. In the character of its stem however, it agrees equally well with Iris virginica of Linnseus and Michaux. It may be doubted whether the plant figured in 156 IRIS VERSICOLOR. the Botanical Magazine, t 703, is more than a va- riety of this species. The characters taken from the comparative length of the stem and leaves, of the inner petals and stigmas, and the direction of the stem and of the stigmas ; are all subject to variation. Michaux, Elliott and Pursh make the Virginica synonymous with Iris hexagona of Wal- ter, which seems permanently distinguished by the deep furrows in the angles of its capsule. The Iris versicolor is found throughout the United States in the borders of swamps and in wet meadows, of which it forms a principal orna- ment in the month of June. Ko race of vegeta- bles can be better marked than the elegant genus to which this plant belongs. They are essential- ly distinguished by a corolla, parted into sisc seg- ments or petals, of which three are rejleaced and three are erect. The stigmas resembling petals. The species m our plate has ensiform leaves, its stem acute on one side, its capsules oblong, three sided, with obtuse angles. Class Triandria,— Order Monogynia.—NsLtnV' al orders, Ensatw, Lin. Irides, Juss. The root is fleshy, horizontal, sending down a multitude of fibres. Stem two or three feet high, round on one side, acute on the other, frequently branched, and bearing from two to six flowers. BLUE FLAG. 157 Leaves sword shaped, striated, sheathing at base. Bractes becoming scarious. Peduncles of yarious length, flattened on the inside. Germ three cor- nered, with flat sides and obtuse angles. Outer petals of the flower spatulate, beardless, the bor- der purple, the claw variegated with green, yel- low and white, and veined with purple. Inner petals erect, varying in shape from spatulate to lanceolate, usually paler than the outer, entu'e or emarginate. Style short, concealed; stigmas tliree, petal-form, pm^ple or violet, resting on the outer petals, then* extremeties bifid, crenate, and more or less reflexed ; their lower lip short. Stamens concealed under the stigmas, with oblong-Hnear anthers. Capsule three celled, three valved ; when ripe, oblong, turgid, three sided, with round- ish angles. Seeds numerous, flat. The young leaves of this and some other spe- cies of Iris, aiford an excellent view of the spiral filament, wliicli lines the sap vessels of the leaf. If a leaf, which has just emerged from the gi^ound, be carefully broken across, and the segments , gradually drawn asunder, these fine filaments will unroll themselves, and their spiral structure be- come very obvious to the microscope. The root of the Iris versicolor has a nauseous taste, and when swallowed or held in the mouth. 138 lllIS VERSICOLOR. even in small quantities, it leaves behind a pow- erful sense of heat and acrimony in the fauces. Its most active chemical constituent appears to be a resin, which separates in the form of a white precipitate, when water is added to the alcoholic solution. The decoction suffers little or no change with alcohol, gelatin or salts of iron. Mu- riate of tin aifects it slightly, the nitrate of mer- cury more abundantly. Its taste is much weaker than that of the tincture. Water distilled from the root has a highly nauseous taste and odour. The root of the Iris versicolor given medicin- ally is an active cathartic. Mr. William Bartram, in his travels in Georgia and Florida, informs us, that on his arrival at Ottasse, an Indian town on the Tallapoose, he found the natives " fasting, tak- ing medicine, and praying, to avert a grevious ca- lamity of sickness which had lately afflicted them, and laid in the grave abundance of then* citizens. The first seven or eight days, during which time they eat or drink nothing, but a meagre gruel made of a little corn-flour and water ; taking at the same time, by way of medicine or physic, a strong decoction of the roots of the Iris versicolor^ wliich is a powerful cathartic. They hold this root in high estimation, and every town cultivates a little plantation of it, havihg a large artificial BLUE FLAG. 159 pond just without the town, planted and almost overgrown with it." Having myself formerly made use of this root in dispensary practice, I can hear testimony to its efficacy as a medicine, though not altogether to its convenience. A small quantity of the re- cent root, or a few grains of the root newly dried, are generally certain and active in their operation on the bowels. They are however apt to occasion a distressing nausea like sea sickness, with a pros- tration of strength of some hours' continuance ; so that I think the plant will not he like to come into favor as a cathai'tic, at least when better ones are at hand. The activity of this article is dimin- ished by age. The stimulating properties of the Iris render it capable of exciting many of the secretions, as well as excretions. But I know of no purpose for which it seems better calculated, than that of a diuretic. The late Dr. Macbride of Carolina as- sured me, that he had found great benefit in drop- sical alFections from a decoction of the roots of this plant in combination with those of Eryngium yuc- cifolium. In consequence of iiis recommenda- tion, I administered the tincture of the Iris in small doses to several persons affected with ana- sarca and with hydro thorax. It was evidently of SI 160 IRIS VERSICOLOR. service to a majority of those who took it, for a cer- tain time. That it did not always cure the dis- ease, is a reproach which it must divide with diuret- ic remedies of much older celehrity. The Iris gracilis, a species descrihed in the Florula Bostoniensis, the Iris pseudacorus of Eu- rope, and several others of the genus, appear to possess properties very similar to those of the plant described. BOTAJSICAL REFERENCES. Iris versicolor, Lin. Sp. pi. — DtLiEiyius, Elth. t 155.—. Curtis, Bot. Mag. t. 21, a variety. — ^Pursh, i. 29. — ^Eixiott^ Can i. 45, Walter, Car, 67. MEDICAL REFERENCES. Bartram, travelSf 454, Lond. edit. — Cutier, Mem. Jimer, Acad. 405 — 6. — Macbuibb, in Elliott^ s Car. i. 45. PLATE XVI. Fig. 1. Iris versicolor. Fig. 2. Style and stigmas with a stamen. Ti .^rvn. ,7ry/t.j FoTHERGiLL, Med. Soc. Lond. i. 310. — Ho3IE> clinical escfts-. 22 168 HYOSCYAMUS NIGER. 197. — ^Withering, Med. Cmiment. Bee. II, vi. SGr.— Kifg- lAKE, Lond. Med. and Fhys. Journal^ v. 438. — Brown, dittOf iii. 406. — Murray, ^pp, Med. i. 655, &c. &c. PLATE XVII. Fig. 1. Hyoscijamus niger. Fig. 2. Corolla laid open. Fig. S. Calyx. Fig. 4. Calyx of the fruit laid open to shew the capsuk within it. Tl .^ijn. •''■'?■ ^1- ■^• ^=J^^^//h' yC^f^^/a Tia m. LOBELIA INFLATA. Indian tobacco^ PL^TE XIX, In the United States there are many species of Lobelia, wliich are interesting for their beauty singularity or use. We have few plants more' elegant than the cardinal flower, and few more curious in structure than the Lobelia Dortmanna. In medicinal powers, the subject of this article is entitled to take precedence of the rest. It is an annual plant, found in fields and road sides, from Canada to the southern states. It flowers from midsummer until the arrival of frosts. The genus Lobelia h^^ a five cleft caly^ ; a monopetalous, irregular corolla, with a cleft tube; the anthers cohering; the capsule two or three celled. The species inflata is branching and hairy, with ovate, serrate leaves, and turgid capsules. 178 LOBELIA INFLATA. The connexion of the anthers into a tube has caused some ambiguity and difference of opinion, as to the place wliich this genus should occupy, in the Linn^an system. Linnseus placed it in his order Monogamia of the class Syngenesia. Most of our late botanists haye very properly remov- ed the plants of this order from the compound flowers, with which they have no natural affinity, to Pentandria, which place their number of sta- mens authorizes them to occupy. Pursh has pla- ced the Lobelias under Monadelphia. The Nat- ural order which contains them is the Cam- panacem of Linnseus and Jussieu. The Lobelia inflata vaiies in height from six inches to two or three feet. The small plants are nearly simple, the large ones much branched. Eoot fibrous. Stem erect, in the full sized plant much branched, angular, very hau*y. Leaves scattered, sessile, oval, serrate, veiny and haiiy. Flowers m spikes or racemes, pedunculated, each one in the axil of a small leaf. Segments of the calyx lineal*, acute, standing on the germ, which is oval and striated. Corolla bluish purple, the tube prismatic and cleft above, the segments spreading, acute, the two upper ones lanceolate, the three lower ones oval. Anthers collected in- to an oblong, curved body, purple ; fdaments INDIAN TOBACCO. 179 wliite. Style filiform ; stigma cm*ved and inclos- ed by the anthers. Capsides two celled, tui'gid, oval, compressed, ten angled, covered with the ca- lyx. Seeds numerous, small, oblong, brown. The Lobelia inflata when broken, emits a milky juice. When chewed, it communicates to the mouth a burning, acrimonious sensation, not un- like the taste of green tobacco. It exhibits the following noticeable ingredients upon chemical examination. 1. An acritl principle. This is ev- ident to the taste in the tmcture, decoction, and distilled water. S. Caoutchouc. Sulphuric ether dissolves more of the plant than alcohol, and ac- quires a higher colour. The solution in alcohol is scarcely rendered turbid by water, that in ether is disturbed by alcohol, and grows tliick as the ether evaporates. 3. Extractive. 'No gummy or astringent fjualities were manifested in my exper- iments. The great acrimony of the leaves and capsules, combined with a narcotic property, appears to be the foundation of their medicinal power. Dr. Cutler informs us, that if the leaves be held for some time in the mouth, they produce giddiness and pain in the head, with a trembling agitation of the whole body, and at length bring on nausea and vomiting. These effects are analagous to 180 LOBELIA INFLATA. those, which the chewing or smoking of tohacco occasions in persons unaccustomed to its use. When swallowed in substance, it excites very speedy vomiting, accompanied with distressing and long continued sickness, and even with dan- gerous symptoms, if the dose he large. A melan- choly instance of death, occasioned hy the use of this plant, in the hands of a quack, is detailed in the sixth volume of the Massachusetts Reports, in the trial of Samuel Thomson, an empiric practising in Beverly, for the murder of Ezra Lovett, In this trial it appeared, that the patient, being con- fined by a cold, sent for the pretended physician, who gave liim three powders of Lobelia in the course of half an hour, each of wliich vomited liim violently, and left him in a great perspiration during the night. The next day two more pow- ders were administered, each of which operated by vomiting and occasioned great distress. In like manner two other powders were given the subsequent day, leaving the patient in a state of great prostration. Several days after this, the physician came again, and finding his patient still worse, administered several more powders, which occasioned great distress, and at length ceased to operate. Finding that the stomach was not sensible to the emetic effect of the Lobelia, INDIAN TOBACCO. 181 the physician repeated the dose, and when the pa- tient complained of great distress at the hreast and said he was dying, the doctor assured him the medicine would soon get down, or operate as a ca- thartic. However, on the same evening, the pa- tient lost his reason and became convulsed, so that two men were required to hold him. To relieve which, the doctor forced down two more of his powders, and the patient, as was to be expected, grew worse, and continued so until he expired. The doctor, who had thus terminated the dis- ease and the patient at once, was arrested and put upon trial for murder ; but the homicide proving a legitimate one from the want of sufficient evi- dence of malice propense, he was acquitted and set at liberty. From the violence of its effects, and the dis- tressing nausea which it occasions, it is probable that the Lobelia will never come into use for the common purposes of an emetic, while other emet- ics can be obtained. , It has however been found to exert a beneficial influence on particular diseas- es, and on this account is entitled to a place in the Materia Medica. Dr. Cutler, and a number of physicians in Essex county and elsewhere, have found benefit from its use in asthma, some in dos- es of a table spoonful of the saturated tincture, 18S LOBELIA INPLATA. others in doses of a teaspoonfiil. Indeed the for- mer dose appears to be a very large one, and greater than most stomachs would bear with im- punity. I have tried tliis medicine in several cases of asthma with some advantage. It has not however in general succeeded in affording re- lief of the paroxysm, until full vomiting was pro- duced, which effect, with me, has happened after taking one or two teaspoonfuls. A communication from Dr. Cutler, on the op- eration of this plant, is inserted in Dr. Thacher's Dispensatory. The venerable writer having him- self suffered from asthma for ten years, had, dur- ing the paroxysms, resorted to many medicines for relief, without experiencing much benefit from any. He was at length induced to make trial of a tincture, prepared by liimself from the Lobelia inflata. " In a paroxysm," says he, "which per- haps was as severe as I had ever experienced ; the difficulty of breathing extreme, and after it had continued for a considerable time, I took a ta- ble spoonful. In three or four minutes my breath- ing was as free as it ever was, but I felt no nau- sea at the stomach. In ten minutes I took anoth- er spoonful, which occasioned sickness. After ten minutes I took a thu'd, which produced sensi- ble effects upon the coats of the stomach, and a / INDIAN TOBACCO. 183 very little moderate puking^ and a kind of prickly sensation through the whole system, even to the extremities of the fingers and toes. But all these sensations very soon subsided, and a vigour seemed to be restored to the constitution, which I had not experienced for years. I have not since had a paroxysm, and only a few times some small symptoms of asthma. Besides the violent at- tacks, I had scarcely passed a night without more or less of it, and often so as not to be able to lie in bed. Since that time I have enjoyed as good health, as perhaps before the first attack." Dr. Cutler considers his disease to be what Dr. Bree in his " Practical inquiries on disorder- ed respiration" calls the first species, " an asthma from pulmonic iiTitation of effused serum." Dr. Randall informs me, that he has given the Lobelia to many persons of different ages suffer- ing from asthma and catarrh, and with considera- ble variation in the form and degree of the dose. In asthma he finds it as successful as any article he has tried. When given in doses of a drachm of the saturated tincture, and two or three times repeated at convenient intervals ; also in the form of other preparations of similar strength, he has found it usually to remove the paroxysm in a short time, and to restore the patient to qui- 24 184 LOBELIA INFLATA. etude and case. In catarrh, when given in small doses and frequently repeated, it has op- erated as a sure and speedy expectorant, pro- ducin,^ effects in then' most important character, very similar to those of antimony and squills. Dr. Randall has not observed any narcotic effect to ensue from moderate doses, nor found it to pro- duce uTitation of the coats of the bladder, as has been suggested by some practitioners. In his hands it has not produced any more unpleasant consequence than frequent nausea, and occasional emesis, with a copious flow from the glands of the mouth. Dr. Bradstreet of Newburyport acquaints me, that besides asthmatic cases, he has given the sat- urated tincture in two or three instances of dys- pepsia, also in some cases of a rheumatic nature with beneficial consequences. He considers its sensible effects to be very like those of common tobacco, but its medicinal action moi*e speedy and difilisible, and of shorter duration. He thmks that it affects those accus- tomed to the use of tobacco as readily as others. The Lobelia has been recommended as a rem- edy in hooping cough and croup. In the former of these complaints, I can say nothing of its use from experience, but in the latter disease I am INDIAN TOBACCO. 180 persuaded, it aifords no benefit, having seen it largely tried b j different practitioners in a number of fatal cases, where it only produced a distress- ing nausea, without, in any degree, facilitating the respiration, or relieving the disease. The active properties of the Lobelia are readi- ly extracted both by water and alcohol. The tinc- ture however is most easily kept, and is the most convenient form for exhibition. The Essex dis- trict medical society have recommended a formu- la for this composition, which dii'ects two ounces of the dried plant to be digested in a pint of di- luted alcohol. Of this tincture, a teaspoonful giv- en to an adult, will generally produce nausea, and sometimes vomiting. In certain instances how- ever, much larger doses have been given, without producing any other effect than a flow of saliva. BOTANICAL REFERENCES. Lobelia inflata, Lijf. Sp. pi. — Act. Vjjsal 1741, p. 23, t 1.— Gronovius, Virg. 134.— Wiild. Sp,plA. 946.— Michaux, ii, 142. — PuESH, ii. 448. MEDICAL REFERENCES. Ctjtlee, Mem. Jimer. Jlcad. i. 484 Schoepf, 128. — Bart, CoL 36, 56.— Thacher, Disp. Q67,— Massachusetts Reports^ vol, vi. 186 LOBELIA INFLATA. PLATE XIX. Fig. 1. Lobelia injlata. Fig. 2. Corolla with the stamens projecting from the cleft in the upper side. Fig. 5. Capside cut across. ri^^jr ' ',.f/f>^'^. SOLIDAGO ODOEA. Sweet scented Golden rod. TLdTE XX. JN o part of vegetation in the United States is so conspicuous and gaudy in the autumnal months, and at the same time furnishes to the botanist so difficult a task of discrimination, as the multitu- dinous and Protean genera Solidago and Aster. Each of these genera contains many well defined species, sufficiently marked by their external characters, sensible qualities, habits and places of growth. But between them, is a great multitude of subspecies, liable to variation from external circumstances, changing their appearance with their places of growth, and running together by so many points of resemblance, that it is a labour yet remaining for botanists to separate those species which are in nature distinct, from those which are varieties onlv. 188 SOLIDAGO ODORA. The genus Solidago is characterized by a na- ked receptacle, the down simple, rays of the corolla about Jive, scales of the Qalyao imbricated and close. It is a very natural genus, easily distinguished at sight by its crowded tufts of compound flowers, which are almost always of a deep golden yellow.* The species odora has its stem nearly smooth, leaves linear-lanceolate, entire, smooth, with a rough margin, and covered with pellucid dots, Macemes panicled, one sided. Class Syngenesia, — Order Superjiua, — Natural orders Compositor, Lin. Corymhiferce, Juss. The sweet scented Golden rod grows in wootls and fields throughout the United States, and flow- ers in September. It has a smooth appearance, and is among the smaller species of its family. The root is woody, much branched and creeping. Stem slender, from two to three feet high, smooth or slightly pubescent below, pubescent at top. The leaves are linear-lanceolate, closely sessile, broad at base, entire, acute, with only the midrib distinct, rough at the margin but otherwise smooth, and covered with pellucid dots, like Hy- pericum perforatum. The flowers grow in a com- pound, panicled raceme, with each of its branches * The only exception which I now recollect is Solidago hicoloTy whose ray is white. SWEET SCENTED GOLDEN ROD. 189 supported by a small leaf. These branches or peduncles are very slender and rigid, each giving off a row of ascending, downy pedicels, with small, linear bractes at their bases. Scales of the calyx oblong, acute, smooth, or slightly pubescent, the lower ones shorter and closely imbricating the rest. Florets of the ray few, with oblong, obtuse, ligules. Those of the disc funnel shaped, with acute segments. Down simple to the naked eye, feathery under the microscope. Seeds oblong. This plant is the Solidago odora of Muhlen- berg, and agrees with the character of Alton. The Solidago odora of Michaux is possibly a differ- ent species. Willdenow's plant was undoubtedly different. The folia pmicticulosa, which consti- tutes so distinct a mark in this species, I have not seen noticed by any botanist. The leaves of the Solidao:o otlora have a delio'lit- fully fragrant odour, partaking of that of anise and sassafras, but different from either. When sub- jected to distillation, a volatile oil, possessing the taste and aroma of the plant in a high degree, col- lects in the receiver. This oil apparently has its residence in the transparent cells, which consti- tute the dotting of the leaves, for the root is whol- ly destitute of the peculiar fragrance of the herb, and has rather a nauseous taste. This is contra- 190 SOLID AGO ODORA. ry to the remark of Willdenow, who informs us that the root is the fragrant part possessing the scent of Geum urbanum. As the volatile oil appears to possess all the medicinal v alue of this plant, I haye not proseciit- ed its chemical investigation any farther. The claims of the Solidago to stand as an ar- ticle of the Materia Medica are of a humble, but not despicable kind. We import and consume many foreign drugs which possess no virtue be- yond that of being aromatic, pleasant to the taste, gently stimulant, diaphoretic and carminative. All these properties the Golden rod seems fully to possess. An essence macle by dissolving the es- sential oil in proof spirit, is used in the eastern states as a remedy in complaints, arising from flat- ulence, and as a vehicle for unpleasant medicines of various kinds. I have employed it to allay vomiting, and to relieve spasmodic pains in the stomach of the milder kind, with satisfactory suc- cess. From its pleasant flavour, it serves to cover the taste of laudanum, castor oil, and other med- icines, whose disagreeable taste causes them to be rejected by delicate and irritable stomachs. Mr. Pursh inforins us, that this plant when dried, is used in some parts of the United States as an agreeable substitute for tea. He further states. GOLDEN ROD. 191 that it has for some time been an article of ex- portation to China, where it fetches a liigh price. BOTANICAL REFERENCES. Solidago odora, Aiton, Eort. Keiv. iii. 214. — Puesh, ii. 539. — Virga Aurea Americana, Tarraconis facie et sapore, panicu- la speciosissima ? TiaUHewet, Mm, 389? t. 116,/, 6. PLATE XX. Fig. 1. Solida odora. Fig. 2. Ajiower magnified. Fig. 3. AJloret of the ray. Fig. 4. AJloretof the disc. 25 NOTES. jMost European writers seem to considei* the Datura stra- monium as a native of America. In Miller's Dictionary by Martyn, the editor says, « That it is a native of America, we have the most undoubted proofs, for in earth brought with plants from various paiis of that extensive country, we are sure to have the Tliorn apple come up. Kalm says, that it grows about all the villages, and that this and the Phytolacca are the worst weeds there. Our old writers call it Thorny Apples of Peru." This evidence however is by no means sufficient. The plant appears in earth and ballast, carried from either continent alike. The name Apple of Peru has also been applied to Datura metel, a plant of Africa and the East Indies. JVofe B. In the Catalogue of plants in the Botanic garden at Calcutta, published in 1814, a species is inserted by the name of Datura Tatula, said to be a native of the Cape of Good Hope. TMs is probably different from the Datura Tatula of Linn^us. JS^ote C. <' The Jamestown weed, (which resembles the thorny apples of Peru, and I take it to be the plant so called,) is supposed to be one of the greatest coolers in the world. This being an early plant, was gathered very young for a boiled sallad, by some of the soldiers sent thither to quell the rebellion of Bacon ; and some of them ate plentifully of it, the effect of which was a very NOTES. 193 pleasant comedy, for they turned natural fools upon it for several days. One would blow up a feather in the air, another would dart straws at it with much fury ; another stark naked was sit- ting up in a corner like a monkey, grinning, and making mows at them ; a fourth would fondly kiss and paw his companions, and sneer in their faces with a countenance more antic, than any in a Dutch droll. In this frantic condition they were confined, lest, in their folly, they should destroy themselves. A thousand simple tricks tliey played, and after eleven days returned to themselves again, not remembering any thing that had passed." Beverly's History of Virginia, p. 121. JTote B, «f De Cuechyliztomatl, sen Tomatl sonalis. Genus est Solani Tonchiclii forma et viribus simile, sed foliis paulisper undulatts, et fructu acinoso racematimque depen- dente, kc" Hernandexif ii. 12. J^ote E, <' I am heartily glad to hear more instances of the success of the Poke weed in the cure of cancer. You will deserve highly of mankind for the communication. But I find in Boston they are at a loss to know the right plant, some asserting it is what they call Mechoacan, others other things. In one of their late pa- pers it is publicly requested that a perfect decription may be giv- en of the plant, its places of growth, &c. I have mislaid the pa- per, or would send it to you. I thought you had described it pretty fully." Letter from Dr. Franklin to Br. Colden, " I apprehend that our poke- weed is what botanists term Phytolacca. This plant bears berries as large as peas. The skin is black, but it contains a crimson juice. It is this juice thickened by evaporation in the sun which was employed. It caused great pain, bui some persons were said to have been cured, I am not quite certain of the facts ^ all that I know is 194^ NOTES. that Dr. Colden had a good opinion of the remedy." Letter from Dr. Franklin to M. Dubourg. Xote F. Liiinseus, in his Flora Laponica, tells us that the roots of Calla palustris, although acrid and caustic in the highest degree, fignis Jirme instaVfJ are made into a kind of bread in high esti- mation, called Missebroed. This is performed by drying and grinding the roots, afterwards boiling and macerating them un- til they ai'e deprived of acrimony, when they are baked like other farinaceous substances into bread. The recent juice of the Jatropha manihot, or Cassava tree of the West Indies, is highly poisonous. The deleterious princi- ple however resides in a volatile portion, which is dissipated by heat. The remaining substance of the root is used by the in- habitants for bread, as a material for a kind of soup, and as the basis of a fermented liquor. JS^ote G. The following is Kgempfer's description taken from his Amoe- iiitates Exoticse, p. 791. His accompanying figure resembles the American Rhus vernix, except, that the end of the branch and bud are larger in proportion than with us. « 8it%f vel. SitzdsjUf i. e. SitXi planta, vulgo Urus seu Uiiis no Jii, Arbor vernicifera legitima, folio pinnato Juglandis, fructu racemoso ciceris facie. " Arbor paucis ramis brachiata, salicis ad altitudinem luxuri- ose exsurgit. Cortice donatur incano, ex verruculis scabro, facile abscedente ; ligno saligneo fragillimo ,• medulla copiosa, ligno adnata i Surculis longis crassis in extreraitate inordinate foliosis. Folium est impaiiter pennatum, spithamale vel longius, Juglandis folio semulum, costa tereti, leviter lanuginosa ; quara a semipal- mari nuditate stipant lobi sive folia simplicia, pediculo perbrevi nixa, tenuia, plana, ovata, trium vel quatuor unciarum longitu- NOTES. 195 dinis, basi insequaliter rotunda, mucrone brevi angusto, margine integro, suprema facie obscure viridi, Isevi, et ex nervis lacunosa, dorso incano et molliter lanuginoso. Nervus mediiis in mucro- nem terminans subinde miiltos a latere demittit nervos minores, eitra marginem deficientes. Sapor folio sylvestris inest, cum sensibili calore ; humor afFrictus extemplo chartam ferrugineo colore imbuit. In surculis quibusdam ex foliorum axillis sin- guli surgunt Racemi laxe ramosi, palmares, tenues, qui, petiolis in calyculos rotundos desinentibus, Fhsculos continent pumilos, et citra Coriandri seminis magnitudinem radiantes, in luteum lierbaceos, pentapetalos, petalis carnosis noniiihil oblongis et repandis ,- staminibus ad petalorum interstitia singulis, apicatis, brevissimis, stylo perbrevi tricipite, floris turbini insidente. Ordorem spirant dulcera, Aurantio llori affinem et pergratum. JFrudus flosculura excipit gibbosus, utcumque in rhomboidis figu- ram compressus, bifidus, facie ac magnitudine ciceris, mem- branula tenui raicante vestitus, per maturitatem durissimus et obsoleti coloris. ^* Cortex arboris cultro crenatus lacteum fundit lentorem, liumore crystallino (ex aliis diictibus stillante) permixtum, qui ad aeris coiitactum nigrescit. Eimdem surculi divulsi, foliorum pediculi, et nervi produnt, nuUius gustabilis qualitatis partici- pem, nisi califacientis sine acredine. Venenatos tamen spiritus hsec arbor exhalare dicitin% vehementes adeo, ut pueris circa eandem conimorautibus exanthemata in corpore pariant : qualia etiam lignum tractantes alii (non omnes) experiuntur. Collectio Urusj, sive Vernicis, ut instituatur, caudices prsecipue triennes, paucis crenis vulnerandfs sunt, ex quibus stillans liquor subinde excipitur, iterata in reccnte loco sectione, donee exsucci marces- eant. Emulsi atquc omni succo orbati, illico amputandi sunt ; sic nova e radice provenit soboles, quse, triennis facta, coUectioni denuo subjicitur/' ^ * * <' Vernix nativavix prseparatione indiget, Japonica per dupli- catam chartam siibtilissimam, telee aranearum pene similem, et 196 NOTES. earn in rem singulariter constructara docta ey^et^tjTt torqueii solet, ut a particulis heterogeneis et crassioribus mundetur; mundatse pauxillum admiscetur (centissima fere pars) olei Toi dicti ex finictu arboris Mri, Sic vasibus ligneis iudita per Japo* niam venalis traiisvehitur." J\*ote H. The following account of the death of Socrates is translated from the Phcedon of Plato. And Crito hearing this gave the sign to the boy who stood near. And the boy departing after some time returned bringing with him the man, who was to administer the poison, who brought it ready bruised in a cup. And Socrates beholding the man, said, *< Good friend, come hither, you are experienced in these affairs, — What is to be done ?" ** Nothing," replied the man, " only when you have drank the poison, you are to walk about until a heaviness takes place in your legs. Then lie down. This is all you have to do." At the same time he presented him the cup. Socrates received it from him with great calmness, without fear or change of countenance, and regarding the man with his usual stern aspect, he asked, " What say you of this potion ? Is it lawful to sprinkle any portion of it on the earth as a libation, or not I" " We only bruise," said the man, " as much as is barely sufficient for the purpose." " I understand you," said Socrates, « but it is certainly lawful and proper to pray the gods that my departure from hence may be prosperous and happy, which I indeed beseech them to grant." So saying, he carried the cup to his mouth and drank it with great prompt- ness and facility. Thus far most of us had been able to refrain from weeping. But when we saw that he was drinking and actually had drunk the poison, we could no longer restrain our tears. And from me they broke forth with such violence, that I covered my face and deplored my wretchedness. I did not weep for his fate, so much. NOTES. 197 as for the loss of a friend and benefactor, which I was about to sustain. But Crito unable to restrain his tears was compelled to rise. And Apollodorus, who had been incessantly weeping, now broke forth into loud lamentations, which infected all who were present except Socrates. But, he observing us, exclaimed, <« What is it you do, my excellent friends ? I have sent away the women that they might not betray such weakness. I have heard that it is our duty to die cheerfully and with expressions of joy and praise. Be silent therefore, and let your fortitude be seen." At this address we blushed and suppressed our tears. But So- crates, after walking about, now told us that his legs were begin- ning to grow heavy, and immediately laid down, for so he had been ordered. At the same time the man who had given Mm the poison, examined his feet and legs, touching them at inter- vals. At length he pressed violently upon his foot, and asked if he felt it. To which Socrates replied, that he did not. The man then pressed his legs and so on, shewing us that he was becoming cold and stiff. And Socrates feeling of himself assured us, that when the effects had ascended to his heart he should then be gone. And now tlie middle of his body growing cold, he threw aside his clothes and spoke for the last time, ** Crito, we owe the sacrifice of a cock to JEsculapius. Dis- charge this and neglect it not." " It shall be done, said Crito ; have you any thing else to say ?" He made no reply, but a mo- ment after moved, and his eyes became fixed. And Crito seeing this, closed his eyelids and mouth. CONTENTS OF THE FIRST VOLUME, Datura stramonium, Eupatorium perfoliatumf Phytolacca decandra, Arum tnphyllum, Coptis trifolia. Arbutus uva ursi, Sanguinaria canadensis. Geranium maculatum, Triosteum perfoliatum, Itliux vernix, Conium maculatum, Cicuta macidata, Kalmia latifolia, Spigelia marilandicaf Asarum canadense, Iris 'versicolor, Hyoscyamus niger, Solanum dulcamara, Lobelia injlata, Solidago odora, M)tes, Thorn apple, page 17 Thorough wort, 33 Poke, 39 Dragon root, 52 Gold thread, 60 Bearberry, 66 Blood root, 75 Craneshill, 84 Fever root, 90 Poison sumach, 96 Hemlock, 113 American hemlock, 125 Mountain laurel, 133 Carolina pinkroot, 142 Wild Ginger, 149 Blue flag, 155 Henbane, 161 Bitter sweet, 169 Indian tobacco, 177 Sweet scented Golden rod, 187 192 ADVERTISEMENT. Upon presenting to the public the portion of this work, which completes one half of his labours, the author of the American Medical Botany feels himself bound to offer some report of the progress and prospects of his undertaking. The plan of this work was formed and announced at a time when such a subject was wholly novel, and when coloured bo- tanical engravings, from the difficulty and expense of their exe- cution, were almost unknown in this country. It was endeav- oured that the plan should be such as in some degree to insure, what both authors and their friends should desire, extensive cir- culation and permanent utility. An edition of a thousand copies was printed, and that the work miglit be generally accessible, the price was fixed at a lower rate, in proportion to the number of plates, than works of the kind have ever been placed at in this country; a rate which the probable sale of the whole edition could alone justify. As permanent utility was esteemed of more importance than ephemeral success, the work has not been hur- ried in any stage of its execution, even though some temporary advantages might have been obtained by its earlier appearance. The author has not willingly adopted the opinions of others in bot- any or medicine without examination, and has thought no delay in- jurious which might lead to the establishment of truth or the de- tection of error. He has been desirous, in adding the results of his own experience, that the book should have, in some degree at VI ADVERTISEMENT. least, the character of an original work, rather than of a compi- lation ; at the same time that it should present a fair view of what is known on the subjects of which it treats. The figures of the plants have, in every instance, been made from original drawings, which were executed by himself, with the exception of two or three presented by his friends. Tlie style of engraving is wholly new in this country, and is one which has been suc- cessfully attempted only by the first artists in France. It gives him pleasure to state, that the reception of the work, in all parts of the United States, has exceeded his anticipations, that the subscription is already more than sufficient to defray the expense of publishing, and that its regular increase renders it probable that the whole edition will be taken up at an early period. He avails himself of this occasion to return his acknowledg- ments to those correspondents who have obligingly assisted him by the communication of specimens for the work, and of the re- sults of their own researches and experience. Particularly he would express this remembrance to Zaccheus Coixins Esq. of Philadelphia, a gentleman whose active kindness has repeatedly supplied his botanical necessities ; and whose extensive erudition has enabled him to afford counsel, which would not have been sought at a less respectable source. To Professor Ives of New Haven, a zealous and inteUigent cultivator of the American Ma- teria Medica, he would express the obligations derived from his communications and correspondence. It would be unjust to for- get that many medicinal plants of the Southern States, with ob- servations on their properties, were furnished expressly for this work, by the late Dr. James Macbkide of Charleston, S. C. a 4% ADVERTISEMENT. VIL physician and a botanist, whose premature dcatli has terminated a career of honourable usefulness and of active, liberal and efficient prosecution of science. His friends cannot remember without re- gret a man, who had the rare quality of being learned without ostentation, who was ambitious of usefulness more than of fame, and who sought rather to be valuable to others than just to him- self. As the materials for the rest of the American Medical Bota- ny are now principally collected, and most of the drawings finished ; the remaining numbers will be issued with as much promptness and regularity, as is consistent with their faithful execution. PREFACE TO THE SECOND VOLUME. As frequent use is made in these pages of observations drawn from the auxiliary sciences, as affording some light on the medicinal properties of plants, it may be proper to examine how far tes- timony of this kind is entitled to receive credit in our inquiries and examinations. There can be no question, that the actual op- eration of medicines upon the human system, gathered from positive experience, is, in the pres- ent state of our knowledge, the only criterion by which we can pronounce, with universal certainty, on their properties. There are nevertheless many things to be learnt from chemical analysis, sensible qualities, and botanical affinity, which may afford us, in some instances certainty, and in most others presumptive evidence of the medicinal characters of vegetables. The correspondence in these respects is frequently so striking, that we can hardly resist the belief, that an entire liar= mony of properties exists, which, if we are unable X/ PREFACE. fiiJlv to comprehend, it is rather o'^inpf to the im- perfectioQ of science, than to the iiTeGTularitv of nature. A few illustrations of this point, taken from general facts already ascertained, will place the suhject in a clearer li|;cht. The chemical suhstances. known hr the names of Gum iMuciis and Fascula. are constantly emol- lient, demulcent and nutritious. They manifest these qualities even when extracted from acrid and poisonous vegetables, as in Arum; Calla. and Jatropha. Sugar is nutritious and demulcent. T^Tien subjected to a spontaneous chemical chanjje by the vinous fermentation, it is universally a stroma diffusible stimulus. Fi-xed oils are emollient and laxative. Also nutritious. Volatile oils on the contrary are acrid, stimu- latinjj. heatin^s:. and antispasmodic. Tannin and the Gallic acid are uniformly an- tiseptic andpowerfullv a^trinj;(ent. The ^icetous. Citric. Tartaric and similar veg- etable acids are refrigerant and antiseptic. Bitter Extractive substances are u-ually tonic. JResins. which [ire bitter and acrid, are coni- raonlv cathartic. PREFACE. XI Emetine, as separated by Pelletier and Magen- die, is powerfully emetic. Morphiiim, obtained by Sertnrner, is a vei-y strong narcotic. The foregoing are some of the examples, which the present state of Chemistry allows us to ob- serve of affinity between chemical and medicinal characters. With a few exceptions they will be found to be strictly true. Yet the analysis of vege- tables is at present but imperfectly known, and an extended investigation is continually bringing new principles to light. We can hardly expect that the business of generalization should be attempted with complete success, until tlie constituent facts are better understood. From what we already know, however, it is not chimerical to predict, that if the chemistry of vegetables were as per- fectly known in all its parts, as in those which we have detailed ; their medicinal properties might be inferred, with at least as great certainty, as that which now attends most inferences in the conjectural science of medicine. In regard to the botanical affinities of plants, as affording evidence of their medicinal powers, much has been said and written. Petiver, Hoff- man, Linnaeus, Hasselqnist, and recently the learned Professor Decandolle have bestowed much XU PREFACE. investigation on tliis subject. It is regarded as a desideratum by all, and as the consummation of botanical science by many, tliat plants should be so arranged, as that then* assemblages should agree, not only in external forms, but in internal qualities and operative powers. Certain general agreements of this kind evidently prevail through- out nature ; yet they are so varied, and subject to so many exceptions, that it is difficult to establish them by general scientific descriptions, and when they are rendered too minute they seem to lose much of their importance. It is perhaps as easy to know the properties of plants from theu* exter- nal habit, as to understand the characters of man- kind from their physiognomy. Accurate obser- vers know more than they can communicate the means of knowing to others, yet the most accu- rate are liable to be mistaken. Many vegetables of the closest affinity and resemblance, even spe- cies of the same genus, differ wholly from each other in their effects. Witness the species of Cucumis, Convolvulus, and Solanum, some of which are salutary, and others highly deleteri- ous. Kevertheless there are many general truths, or at least general probabilities, by which every one would be influenced, and w hich have so much importance, that they will never be forgotten. PREFACE. Xlli No botanist, even if in danger of starving in a wilderness, would indulge liis hunger on a root or fruit taken from an unknown plant of the nat- ural order Luridce, of the Multisiliquce, or the um- belliferous aquatics. On the contrary, he would not feel a moment's hesitation in regard to any of the Gramina, the fruit of the Pomacew, and several other natural families of plants, which are known to be uniformly innocent in their effects. The sensible properties of plants afford another clue to their influence on the human system. It is true, that observations derived from this source will not serve us in forming very minute distinc- tions. They are, however, almost always adequate in vegetable productions, to enable us to distin- guish what is innocent and salubrious, from what is noxious and virulent. The brute creation de- pend wholly upon the powers of sense in selecting their food, and this reliance does not often betray them. In regard to mankind it almost uniformly happens, that what is sweet, delicious, or aromat- ic, proves nutritive or salutary ; while on the oth- er hand, vegetable poisons are nauseous, acrid, and disgusting. It has been observed, that it would have been a sort of treachery in nature to have made it otherwise. Considering the univer- sal dissemination of poisonous plants, and the XVI PREFACE. number of them, which frequent the vicinity of human habitations, this arrangement of Provi- dence, by making ungrateful what is dangerous, has furnished ahnost the only safeguard from harm, to the inexperienced and unwary. These remarks have been offered on account of an impression which many persons entertain, that collateral evidences of the characters of plants are worthless and undeserving of attention. Even if the community were composed exclusively of physicians, such an opinion could not be wholly correct. Every one may be called on to form hasty decisions on subjects where his experience is deficient, and where an acquaintance with aux- iliary facts might lead him to a correct issue. It is not onl}^ curious and instructive to perceive the harmonies of nature, but to every inquirer among her works it must be practically useful. It can no where be more useful, or more deserving of study, than in a new country, where the face of nature presents an ungathered harvest, and where every clue to useful discovery derives importance from its influence and tendency. ih' 4 3 & 7 d 9 20 J2 -?5 AMERICAN MEDICAL BOTANY, PYROLA UMBELLATA. Winter Green. PLATE XXL JL his most beautiful of the species of Pjrola is extensively diffused througliout the northern hemisphere. It inhabits all latitudes in the Unit- ed States, and extends across the continent to the shores of the Pacific ocean. It is also found in the forests of Siberia, and in several of the northern and temperate countries of Europe. It only grows in shady woods, where it is protected from the sun, and nourished by the peculiar soil formed from the decomposition of leaves and wood. The most common appellations, by which it is known in the United States, are Winter green and Pipsis^ sewa. It floAvers in June and July, being some- what later than most of the other species of its family. 16 . PYROLA UMBELLATA. By Pursliari(l some other American botanists, this species and one other have been separated from the genus Pyrola, to constitute a new family by the name of Chimaphila. As the grounds of distinction, however, between them are not suffi- cient to render it certain tliat this genus will ul- timately stand ; I have preferred retaining the orisrinal Linnsean name.* * It is somewhat remarkable, that the genus Chimaphila was first established upon characters, which hardly exist in either of the plants it is intended to comprehend. The pxnncipal grounds of distinction, suggested by Michaux and adopted by Pursh, seem to consist in a sessile stigma, and anthers opening by a siibbivalve foramen. Now the stigma is not sessile, since that term implies the absence of a style, and the anthers do not open by any subbivalve foramen, differing from the rest, but by two tubular poi-es, precisely as in the other spe- cies of Pyrola. Mr. Nuttall, in his interesting work on North Ameri- can genera, has amended the character of Chimaphila, by bringing into view the calyx, filaments, &c. while he has added to the char- acteristics of Pyrola, a ilowny connexion of the valves of the cap- sule. In the calyx, however, the two species of Chimaphila are at different extremes from each other ; one of them having a five leaved calyx, the leaves overlaying each other at base ; the other having a five toothed calyx only, while the remaining species of Pyrola, being five parted, come between them. I have not been able to find the tomentum spoken of by Mr. Nuttall, in all the spiked species, and par- ticularly in P. secunda. If the genus Pyrola were ever to be dismembered, it should be into at least four distinct genera, as follows j 1. Style declined, stigma anmdate. P. rotundifolia, P. asarifolia, &,c. WINTEU GREEN. i7 The genus Pyrola belongs to the class Be- candria, and order Monogynia, It ranks among 2. Style straight, stio^ma peltate. P. secunda, P. uniflora, &c, S. Style incrassatedj calyx five leaved^ P. maculata. 4, Style immersed^ calyx five toothed, P. umbellata. If we go farther and take into view the direction and form of the filaments, and the other parts of flower and fruit, with their various combinations ; we shall have nearly as many genera as there are now species, since it is well known that many of the most important spe- cific distinctions in this genus are taken from the fructification. On these accounts there can be no doubt that the genus Pyrola had better remain entire. In habit it is certainly one of the most natural genera we possess. All the species are humble evergreens, growing in woods, with creeping roots, ascending sterns, and nodding flowers. All of them have their leaves in irregular whorls, flower with reversed anthers, and retain their style until the fruit is ripe. In. inflorescence, one is solitary, two somewhat corymbed, and the rest spiked. The leaves of P. secunda, umbellata and maculata are usu- ally in two or more whorls ; those of most others in one radical whorl OF aggregate. One species is said to be leafless. In the dissections accompanying the figure of P. umbellata I have endeavoured to represent the evident gradation of the style from the species in which it is longest, to that in which it is shortest. In the same plate are added some of the varieties of the calyx and stamens. The following remark of Sir James Edward Smith, the learned president of the Linnsean society, is from Rees' Cyclopedia, Jirt. Pyrola. " We can by no means assent to the establishment of that able writer's (Fursh's) Genus Chimaphila, there being surely no di- versity of habrt to support it, nor any character but a diSereuce in the length of the style ; which the other species of Pyrola shew to af- ford admirable specific, but no generic distinctions. 18 PYROLA UMBELLATA. tlie Bicornes of Linnaeus and the Ericw of Jus- sieu. The generic character is as follows. Calyx mostly jive parted ; petals jive ; anthers inverted^ opening hy two tubular pores ; capsule jive celled, jive valved. The species umhellata has its leaves wedge shaped and toothed, flowers somewhat umhelled, calyocfive toothed^ and style immersed. Its more minute description is as follows : Root woodj, creepin,^, sending up stems at various distances. The stems are ascending, somewhat angular, and marked with the scars of the former leaves The leaves grow in irregular whorls, of which there are from one to four. They are evergreen, coriaceous, on very short petioles, wedge shaped, subacute, serrate, smooth, shin- ing, the lower surface somewhat paler. The flowers grow in a small corymb, on nodding pe- duncles, which are furnished with linear bractes about their middle. Calyx of five roundish suba- cute teeth or segments, much shorter than the corolla. Petals five, roundish, concave, spreading, cream coloured, with a tinge of purple at base. Stamens ten. Filaments sigmoid, the lower half fleshy, triangular, dilated, and slightly pubescent at the edges ; the upper half filiform. Anthers WINTER GREEN. 19 two celled, each cell opening by a short, round, tubular orifice, which points downward in the bud, but upward in the flower. Pollen white. Germ roundish, depressed, furrowed, obscurely five lobed, with a funnel shaped cavity at top. Style straight, half as long as the germ, inversely conical, insert- ed in the cavity of the germ, and concealed by the stigma. Stigma large peltate, convex, moist, ob- scurely five rayed. Capsules erect, depressed, five celled, five valved, the partitions from the middle of the valves. Seeds linear, chaffy, very numerous and minute. This plant, like the other species of Pyrola, is very difficult to cultivate, when transplanted from its native soil; although it thrives luxuriantly in the shade and rich mould of the forests where it originates. The leaves of P3 rola umbellata, when chewed, communicate to the mouth a taste which partakes of both sweet and bitter. The stalk and roots possess the same taste, combined with a moderate degree of pungency. A Dissertation " De Pyrola umbellata," published at Gottingen, by Dr. Wolf, in I8I75 contains an elaborate chemical examina- tion of this plant. As the result of his trials, this author concludes, that 100 parts of Pyrola umbel- lata contain about 18 of a bitter extractive princi- 30 PYROIiA TJMBELLATA pie, 2.04 of resin, 1.38 of tannin, a slight portion of gum, and the rest of fibrina and earthy salts. The resin is adhesive, brownish, readily soluble in etlier apd alkalis, burning with flame and a res- inous odour, and leaving a white cinder. From my own trials the quantity of resin in this plant appears to be very small. A saturated tincture of a deep brown colour does not give a precipitate on the first addition of water. It is only after some time standing, and partly perhaps from the evaporation of the alcohol, that a turbid- ness begins to appear in the solution. It is prob. able that spirit is a better menstruum than watept, for the soluble portions of this plant, although the latter is capable of extracting the greater part of its virtue. The Pyrola umhellata, though scarcely known as a medicine until within a few years past, has at the present day acquired a reputation of con- siderable extent in the treatment of various dis- eases. Its popular celebrity seems to have origi- nated in its application to the treatment of fever and rheumatism ; but the attention of physicians has been chiefly drawn towards its use in other complaints. The instances in which this plant has received favourable testimonies on medical authority, of its successful use, both in America WINTER GREEN. SjL and Europe, are principally the following. 1. As a palliative in strangury and nephritis. 2. As a diuretic in dropsy. 3. As an external stimulant, susceptible of useful application to various cases. In the first of these cases, the Pyrola is entitled to attention and confidence. Some practitioners in this country have employed it with advantage in the same cases, in which the Arbutus Uva ursi is recommended*. Dr. Wolf, the German writer lately cited, has reported a number of cases of ischuria and dysuria, arising from various causes, in which the Pyrola, given in infusion, produced the most evident relief, and took precedence of a variety of remedies which had been tried. His method of administering it was to give a table spoonful of a strong infusion, with a little syrup, every hour. In all the cases he has detailed, small as the dose was, it gave relief in a very short time. In one case its effect was so distinctly marked, that the disease returned whenever the medicine was omitted and was removed on re- suming its use. A tonic operation attended its other effects, so that the appetite was improved and digestion promoted during the period of its employment. * See Dr. Mitchell's Inaugural Dissertation. Philadelphia, 1803. S« PYROLA UMBELLATA. The diuretic properties of the Pyrola umbel- lata, seem to have been fully illustrated by Dr. W. Somerville in a paper on this vegetable, pub- lished in the 5th volume of the London Medico- Chirurgical transactions. The facts presented by this physician afford satisfactory evidence of the power of this medicine to promote the renal excretion, and to afford relief to patients afflicted with dropsy in its various forms. The most dis- tinguished case presented by him, is that of Sir James Craig, the British governour in Canada, who was labouring under a general dropsy, which in its progress had assumed the forms of hydro- thorax, anasarca and ascites, and which was com- bined with different organic diseases, especially of the liver. After having tried with little or tempora- ry success, almost every variety of diuretic and ca- thartic medicines, and submitted twice to the operation of tapping, tlie patient had recourse to a strong infusion of the Pyrola, in the quantity of a pint every twenty four hours. Although the case was altogether an unpromising one, yet the plant gave relief, not only in the first, but in the sub- sequent instances of its use. It increased the urinal discharge, and at the same time produced an augmentation of strength and an invigorated appetite. WINTER GREEN. 3S Several other cases of dropsy are detailed in Dr. Somerville's paper, in which the Pyrola was administered by himself and by other practioners with decided advantage. Dr. Satterly and Dr. Marcet are among those who have added their observations to the testimonies in its favour. Dr. Somerville found his patients to remark, that an agreeable sensation was perceived in the stomach soon after taking the Pyrola, and that this was followed in some instances by an extraordinary increase of appetite. He considers it as having in this respect a great advantage over other diu- retics, none of which are agreeable to the stomach, and most of them very offensive to it. He fur- ther states, that no circumstance had occurred within his own experience or information, to for- bid its use in any form, or to limit the dose. Dr. Wolf has given one very satisfactory case of the utility of our plant in ascites. He also found it to alleviate altogether the ardor urinse attendant on gonorrhea. Such are the most important facts which to my knowledge have been published respecting the internal use of the Pyrola umbellata. I have administered this plant on various occasions, and attended to its mode of operation. In a number of dropsical cases, when first given, it made a dis- ^4? PYROLA U3IBELLA1'A. tinct and evident impression on the disease, com- municating an increased activity to the absorbents, followed by a great augmentation of the excretion from the kidnies. The benefit, however, with me has been in most instances temporary, and it was found better to omit the medicine for a time and to resume it afresh, than to continue it until the system had become insensible to its stimulus. After suspending it for a week or two, the same distinct operation took place on returning to its use, as had been manifested in the first instance. It proved in almost every instance, a very accep- table medicine to the patient, and was preferred both for its sensible qualities and its effects on the stomach, to other diuretics and alteratives which had been prescribed. The Pyrola has been considerably employed as an external application in tumours and ulcers of various descriptions. It first acquired notice in consequence of some newspaper attestations of its efiicacy in the cure of cancer. Those persons who know how seldom genuine cancers occur in comparison with reputed ones, will be more ready to allow it the character of curing ulcerous, than really cancerous affections. There are undoubt- edly many ulcers, and those frequently of a malig- nant kind, which are benefitted by antiseptic WINTER GREEN. S5 stimulants ; ^nd to such the Pyrola may he useful. But of its efficacy in real cancer we require more evidence than is at present possessed, before we ascribe to it the power of controlling so for- midable a malady. Dr. Miller of Franklin informs me that he has used a decoction and cataplasm of this plant with apparent success in various chronic indurated swellings. It acts as a topical stimulant, and when long continued, not unfrequently vesicates. Tumours of long standing have in several in- stances disappeared under its use. BOTANICAL REFERENCES. Pyrola umbellata, Liif. Sp. jyl. Gmeliiv, Flora Sihirica. Roth, Flora Germanica. — Bot. Mag, t. 778. — Michatjx, Flora Americana, i. 251. — Pyrola fruticans, Parkinsox, Theatrum, 509. — J. Bauhin, Mst. plant, iii. 536. — Chiinaphila corymbosa, PuESH, i, 300. — ^NuTTALi, Genera, i. 274. ' MEDICAL REFERENCES. Mitchell, Inaugural Dissertation. — Somerville, Medico- Chirurgical Transactions, vol. v. — ^Wolf, Dissertatio Inauguralis. PLATE XXI. Fig. 1. Ptjrola unibellata. Fig. 2. Pistil of Ptjrola rotundifolia. Fig. S. Pistil of Pyrola secunda. Fig. 4. Pistil of Pyrola uniflora. Fig. 5, Pistil of Pijrola maculata. 4 gg PYROLA UMBELLATA. Fig. 6. Pistil of Pyrola umMlata. ^ Fig. 7. Section of the same, shewing the length of the style. Fig. 8. Five toothed calyx of P. umhellata. Fig. 9. Five leaved calyx and incrassated pedicel of P. ma- calata* Fig. 10. Anther magnified ofF. secunda. Fig. It. Ditto of F. rotundifolia. Fig. 12. Stamen magnified of P. umUllata. Ft"-. 13. Ditto ofF. maculata. XZi^ X J / i u 7 3 ~ -» )(^C/f /J^/'i'^^'J- GAULTHERIA PROCUMBENS. Partridge Berry, PLATE xxrr. HERE is no soil so inhospitable, that it does not afford the means of sustenance and growth to some vegetable tenant. The most arid and penu- rious spots of earth not only give support to a variety of plants, but tliej are even selected by certain species, which make them their perma- nent residence, and thrive better in the midst of poverty and drought than they could in the most fertile and luxuriant situations. The Craultheria procumbeos is one of those hardy and abstemious plants, wbich are better satisfied with the clear air of the mountaios, than with a deep or mellow soil. It is found growing in large beds under the shade of shrubs and trees upon elevated tracts of ground, or upon the sand and gravel of the driest forests. Its bright evergreen leaves seem adapt- ^8 GAULTHERIA PROCUMBENS. ed for ready absorption and slow perspiration, so that it derives from the dews and rain, what the earth fails to supply it. The Gaultheria procumbens is remarkable for the different periods of producing its flowers and fruit. It is found in blossom not only in the early part of spring, but in the last weeks of sum- mer, and the fruit is found ripe at corresponding periods. Whether this appearance is the product of different shoots, or whether the same stems blossom twice in a year, I am unable to say. I have, however, met with beds of the Gaultheria in full flower in August and September, quite as frequently as in May. I have also seen the fruit in the market at various periods of the summer, fall, and spring. The plant takes its vulgar names from the fruit, and is denominated in different parts of the United States, Fartridge berry, Chequer herry, Booc herry, ^c. Its domestic use has also given it the name of Mountain tea. The genus Gaultheria is beautifully singular and distinct in its character, derived from the form of its fruit. The caly.v is jive cleft, caly- ciilated, or Mhracteate at base. Corolla ovate. Capsule five celled, invested with the baccated calyx. PARTRIDGE BERRY. 29 The species prociimheiis has a prostrate stem, with ascending branches. Leaves in a terminal tuft, obovate with a few ciliate serratures. Flowers accillary. Class Decandria, order Monogynia, IVatural orders Bicornes Linn. Ericm Jiiss. The stem, or as it might be called root of this plant is horizontal, woody, often a quarter of an inch in thickness. The branches are ascending, but a few inches high, round and somewhat downy. Leaves scattered, near the extremities of the branches, evergreen, coriaceous, shining, oval or obovate, acute at both ends, re volute at the edge, and furnished with a few small serratures, each terminating in a bristle. Flowers axillary, drooping, on round downy stalks. Outer calyx of two concave, heart shaped leafets, which may with perhaps more propriety be called bractes. Inner calyx monophyllous, white, cleft into five roundish subacute segments. Corolla white, urceolate, five angled, contracted at the mouth, the border divid- ed into five short, reflexed segments, Filaments white, hairy, bent in a semicircular manner to ac- commoelate themselves to the cavity between the corolla and germ. Anthers oblong, orange col- oured, ending in two double horns, bursting out- wardly, for their w hole length above the filaments, 30 GAULTHERIA PROCUMBENS. and not opening by pores as in Pyroia. Pollen white. Germ roundish, depressed, five angled, resting on a reddish, ten toothed, glandular ring. Style erect, straight. Stigma simple, moist. The fruit is a small, five celled capsule, invested with the calyx, which becomes large, round, and fleshy, having the appearance of a bright scarlet berry. If the aroma or odour and also the taste of plants were susceptible of description in as defi- nite language as their proportions and form, the sensible qualities of many vegetables might afford new grounds for generalizing and combining them together. The aromatic flavour of the Partridge berry, which cannot easily be mistaken by those who have once tasted it, may be recognised in a variety of other plants, wliose botanical habits are very dissimilar. It exists very exactly in some of the other species of the same genus, particu- larly in Gaultlieria hisphlula ; also in Spirwa nlma- ria and the root of Spivcea lohata. It is particu- larly distinct in the bark of the Sweet birch, Betula lenta, one of our most useful and interest- ini? trees. This taste and odour reside in a volatile oil, which is easily separated by distillation. The essential oil of Gaultlieria, which is often kept in our druggists' shops, is of a pale or greenish white PARTRIDGE BERRY. 31 colour and perfectly transparent. It is one of the heaviest of the volatile oils, and sinks rapidly in water if a sufficient quantity be added to overcome the repulsion of two heterogeneous fluids. Its taste is aromatic, sweet and highly pungent. The oil appears to contain the chief medicinal virtue of the plant, since I know of no case in which the leaves, deprived of their aroma, have been employed for any purpose. They are nev- ertheless considerably astringent, and exhibit the usual evidences of this property when combined with preparations of iron. The berries, or berry-like calyces, have a pulpy but rather dry consistence, and a strong flavour of the plant. They are esteemed hj some persons, but are hardly palatable enough to be considered esculent. In the colder seasons they afford food to the partridges and some other wild animals. The leaves, the essence and the oil of this plant are kept for use in the apothecaries' shops. An infusion of the leaves has been used to com- municate an agreeable flavour to tea, also as a substitute for that article by people in the country. Some physicians have prescribed it medicinally as an emmenagogue, with success in cases attended with debility. The oil, though somewliat less pun- gent than those of peppermint and origanum, is 3S GAULTHERIA PROCUMBENS. employed for the same purposes. It shares with them the property of diminishing the sensibility of the nerve exposed by a carious tooth, when, repeatedly applied. The essence, consisting of the volatile oil dissolved in alcohol or proof spirit, is antispasmodic and diaphoretic, and may be applied in all cases where warm or cordial stimu- lants are indicated. A tincture, formed by digest- ing the leaves in spirit, possesses the astringency as well as warmth of the plant, and has been use- fully employed in diarrhsea. A respectable physician of Boston informs me, that he has in various instances found the infu- sion of this plant very eifectual in promoting the mammary secretion, when deficient ; and even in restoring that important function after it had been for some time suspended. Whether the medi- cine has any specific influence of this sort, inde- pendent of the general state of the patient's health, I am not prepared to say. BOTANICAL REFERENCES. Gaultlieria procumbens, Liivn. Sp. pi. — Michaux, Flow i. p. 249. — PuESH, i. 283. — NuTTAiL, Gen. i. 263. — Andrews, BoU Repository, t. 116. — Wiild. Arh. 123. — 'Vitis Id^ea Canadensis Pyrolse folio, Tournefort, Inst, 608. — Anonyma pedunculis arcuatis, Coidejt, Mveh, 98. PARTRIDGE BERRY. S3 MEDICAL REFERENCES. Kalm^ Amxnitates ^cademicce, iii. 14, — Bart. Coll. i. 19. PLATE XXIT. Fig. 1. Gaultheria prociimbens. Fig. 2. The bractes or^ outer calyx. Fig. 3. The true calyx. Fig. 4. Stamen of the natural si'ze. Fig. 5. Anther magnifiedf the dark places shewing the mode of opening. Fig. 6. Calyx and pistil. Fig. 7. Fruit. Fig. 8. Longitudinal section of the fruit. Fig. 9. Transverse section of the capsule. PODOPHYLLUM PELTATUM. May Apple. PLATE XXIU, _L HE Podophyllimi peltatum or May apple, otherwise called Mandrake in this country, in- habits low shady situations from New England to Georgia. On the Atlantic coast I have never met with it farther north than Boston, yet in the interior of the country it has a more extensive range. From its large creeping roots, it has a great tendency to multiply, and is always found in beds of greater or less extent. Its flowering time is from March to May. This plant is one of the ^anunculacem of Jus- sieu and Rhoeades of Linn&eus ; and is in the first order of the Class Polyandria. Its generic character consists in a calycc of three leaves ; from six to nine petals ; and a one-cel- led herry crowned with the stigma. Only one spe- an.. 3 i:y^^oJihe^Mi^/7?y Ae/lu^ MAY APPLE. 35 cies is at present known which strictly belongs to the genus. The May apple has a jointed running root about half the size of the finger, by which it spreads extensively in rich grounds, where it gets introduced. The stem is about a foot in height, and invested at its base by the sheaths which covefed it when in bud. It is smooth, round and erect, dividing at top into two round petioles from three to six inches long. Each petiole supports a large peltate, palmate leaf, smooth above, slightly pu- bescent beneath, deeply divided into about seven lobes, which are wedge shaped, two parted and toothed at the extremity. On the inside the leaf is cleft almost to the petiole. In barren stems which support but one leaf this does not take place, and the leaf is very perfectly peltate. In the fork of the stem is a solitary flower on a round nodding peduncle one or two inches long. Calyx of three oval, obtuse, concave leaves, cohering in the bud by their scarious margins, and breaking off at base when the flower expands. Petals from six to nine. Linnseus makes them nine in his gene- ric character, but in this climate I have found them more frequently seven even in luxuriant specimens growing in very rich soil. They are obovate, obtuse, concave, smooth, white with slight 36 PODOPHYLLUM PELTATUM. transparent veins. Stamens shorter than the pe- tals, curving upwards ; the anthers oblong, twice as long as their filaments. Germ oval, compress- ed, obscurely angTilar. Stigma nearly sessile, convex, its surface rendered irregular by nume- rous convolutions and folds. The flower is suc- ceeded by a large ovate yellowish fruit, which is one celled, many seeded and crowned with the stigma. Its early period of ripening has given rise to the trivial name of May apple. The dried root of the May apple is fragile and easily reduced to powder. It has a peculiar and rather unpleasant taste, but without much acri- mony. When chcAved for some time, it manifests a strong bitter taste. Both the tincture and de- coction are intensely bitter. When water is add- ed to the alcoholic solution the mixture becomes very gradually turbid, and at length opaque. On the other hand, alcohol disturbs both the infusion and decoction, especially the latter, in which it produces, after some time, a pearly whiteness. The trials I have made with it lead me to con- clude that it contains a resin, a bitter extractive matter, fsecula and a slight proportion of a gummy substance. The medicinal properties of the Podophyllum peltatum are those of a sure and active cathartic^ MAY APPLE. 37 in which character it deseryes a high rank among our indigenous productions. We have hardly any native plant which answers better the common purposes of jalap, aloes and rhubarb, and which is more safe and mild in its operation. The root is the part to be employed, and should be given in substance in fine powder. I have commonly found twenty grains to operate with efficacy, and not to be attended with pain or inconvenience. In irritable stomachs it sometimes occasions nau- sea and vomiting, but this effect, as is well known, may ensue from any cathartic medicine. The late Professor Barton informs us, that although the root is an excellent cathartic, the leaves are poi- sonous, and the whole plant has something of a narcotic quality. Its botanical affinities would justify, a priori, a suspicion of this kind. In the various trials which I have made with it, I have not observed any such property in the root. The leaves I have never subjected to experiment for any purpose. The fruit is acid and agreeable to the taste of many persons. It is sometimes called wild lem- ons, and is eaten with impunity. The root is said by some physicians to be a medicine particularly suited to dropsy. It has 38 PODOPHYLLUM PELTATUM. also had tlie character in the Southern States of curing intermittent fever. A physician in Albany informs me that the Shakers at Lebanon, N. Y. prepare an extract of the Podophyllum, which is much esteemed by medical practitioners as a mild cathartic. These people are well known to our druggists by the care and neatness with which they prepare a va- riety of medicines from native and naturalized pharmaceutical plants. For medicinal use the root of the May apple is advised to be dug in the cold season, when veg- etation is not active, viz. in the autumn and win- ter. At this part of the year the secretions of perennial plants are concentrated in their roots, and the same weight of their substance is less di- luted with the watery or ascending sap, than it is at any other period. This constitutes a rea- son why the roots of all perennial plants should, as far as practicable, be taken up during the cold season. But from what I have been able to ob- serve, the difference of their virtue in different months is much less than is commonly supposed. I never knew a medicinal plant whose efficacy was destroyed in consequence of being taken up even at midsummer, although it may be in some degree lessened. It is probable that those roots MAY APPLE. 39 which constitute staple articles of commerce, as ipecac, gentian, rhuharb, §c. are gathered indis- criminately for exportation at all seasons when they are to be found. Being collected by savages or by ignorant persons, who seek for them in theu* native wilds, and who are not much interested in their future efficacy ; it is probable they would be gathered in greatest quantities when their vege- tation was most luxuriant, because at this time their shoots and tops would be most conspicuous. We know this to be the case with our Ginseng, Spigelia, Snake root, ^c. which form considerable articles of exportation, and which it would be dif- ficult to find at any other than the vegetating sea- son.* * Annual plants should be gathered at the time when their veg- etation is most vigorous, which is generally from the time they begin to flower, until the leaves begin to change. The leaves contain the greatest activity in most annual plants employed for medicine, while the root is a comparatively insignificant part, being small, woody and fibrous. Thus the leaves of Stramonium and Tobacco are much more active than the root. Biennial plants should, in most instances, be gathered in the second season of their growth, and about the time of flowering. The leaves of these plants also contain their medicinal activity, as in Hem- lock and Henbane. The roots are medicinal, but usually in a less degree. In some aromatic biennials, the seeds are the most impor- tant part of the plant. 40 P0D0PI1YLLU31 PELTATUM. BOTA]>fICAL REFERENCES. Podophyllum peltatum, Lrtof. Sp. pi. — Michaux, Flora^ i. 309. — PuRSH, ii. 366. — Lamarck, Illust. gen, — Trew, Ehret. U 29. — Anapodophyllum Canadense, Catesbt, Car, i. 24. — Aco- iiitifolius humilis &c. Mentz. ^itg-. t. 11, MEDICAL REFERENCES. ScHoePF, 86, — B. S. Bartoij, edit, of CuUenf 375.— «Thach- ER, Disp, 307. — Chapman, Mat, Med, 209. PLATE XXIIL Fig. 1. Podophyllum peltatum. Fig. 2. Calyx, Fig. 3. Stamens, Fig. 4. Germ and stigma. Fig. 5. Fruit. rtJou\'. ICTODES FOETIDUS. Skunk Cabbage. PLJiTE xxir. A HIS is one of our most noticeable plants, both from the frequency of its occurrence and the peculiarity of its sensible properties. Scarcely a swamp or meadow is found in the middle and northern parts of the United States in which this vegetable may not be discovered at a distance, es- pecially in the spring season, by its large tufts of rank, crowded leaves. Its singular flowers are among the first which break from the ground, after the rigours of winter, appearing in different latitudes, from February to April. The vegeta- tion is rapid, so that in most instances the fruit is ripe and the leaves wholly decayed before the end of August. From this precocity of the plant to- gether with the depth to which the roots pene- trate the earth, it seems calculated to bear the 6 4S ICTODES F(ETIDUS. cold of high latitudes. I have found the flowers a second time formed, and shooting from the ground in Kovember. The strong and unpleasant odour which every part of the plant emits on being broken, and which is precisely similar to that of the Viverra mephitis ; has given it by an almost common consent, in every part of the country, the appellations of Skunk weed and Skunk cabbage. The structure of this singular vegetable has caused it successively to be assigned to the gene- ra »irum, Bi^acontium and Pothos, with none of which it fully agrees. Of the Aroidese, to which it is related, it approaches most nearly in its flow- er to Fothos ; while its fruit has more affinity to Orontium. The Eev. Dr. Cutler many years ago, in the Transactions of the American Academy, pointed out the distinctive characters of this plant, and pronounced it a new genus, ^o name, how- ever, substantiated by a character, has to my knowl- edge been given it, in any botanical work, except the name of Symplocarpns, a term lately adopted by some American botanists on the alleged au- thority of Mr. Salisbury. As this name by its ety- mology implies a resemblance of the fruit to Symplocos, a genus with which the plant has not the least affinity ; it appears to me inadmissible. Although I am averse to multiply the confusion SKUNK CABBAGE. 43 of synonyms, with which our science is tdready too much burdened, yet in the present instance an appropriate name, which should not be at va- riance with the character of the plant, appeared to be required. With the advice of the venerahle Dr. Cutler, I have translated, as nearly as possible, the common English appellation for the plant. The name Ictodes from inTig, viverra, and c^oj, oleo ; is sufficiently expressive of the property from which its common name is derived. The genus Ictodes has for its character a hooded spathe, spadicc covered with perfect fiow- ers, calyoc with four segments^ petals no7ie, style pyramidal, seeds immersed i\i the spadivc. Only the present plant can be assigned to this genus. It belongs to Tetrcmdria, monogynia ; and is found among the Piperitce of Linn^us and Jiroidem of Jussieu. The root is large and abrupt, with nu- merous, crowded, fleshy fibres. The spathe which emerges from the ground some time before the leaves, is ovate, swelling, various in width, cucul- late, spotted and sometimes nearly covered with dull brownish purple, the top acuminate and in- curved, the edges infolded, auriculate at base, and at length coalescing. Within this is the oval spadix, on a short peduncle, covered with perfect tetrandrous flowers, and of the same colour with 44 ICTODES FCETIDUS, , the spathe. Calyx leaves four, fleshy, wedge shaped, truncate, the top and edges inflected, the whole crowded together so as to form a compact covering for the spadix. Stamens four, opposite the calyx leaves, with subulate filaments equal in length to the calyx, and oblong four celled anthers. Style four sided, tapering ; stigma minute, pubes- cent ; germ roundish, concealed within the spadix. After the spathe decays, the spadix continues to grow, and with it every part of the flowers except the anthers. When the fruit is ripe, the spadix has attained many times its original dimensions, while the calyx, filaments and style are larger, very prominent and separated from each other. "Within the spadix at the base of each style is a round, fleshy seed, as large as a pea, white, tinged with green and purple, invested with a separate membranous coat, and with a prominent corcu- lum situated in a depression at top. The leaves which spring up some time after the flowers are numerous, large and crowded, ob- long heart shaped, acute, smooth, with numerous fleshy veins of a paler colour. They spring from the root on long petioles, hollowed in front, and furnished with large oblong sheaths. They con- tinae to increase in size for a month or two after the flowering period is past. SKUNK CABBAGE. 45 Mr. Niittall, who has observed the germination of this plant, informs us that the seed does not ap- pear to possesss any other cotyledon, than a sheathing stipule, similar to that which is after- wards produced in the plant. The principle hulk of the seed is formed by what he considers a, yitellus, having the embryo exactly resembling the future plant, situated in an umbilical depres- sion at its top. The attachment of this body to the embryo is at first by a minute funicuhis, which enlarges and becomes more distinct dur- ing the progress of germination ; but the most sin- gular circumstance respecting it is the length of time for which it continues attached to the grow- ing plant, apparently inert at the base of the can- dex for twelve or even eighteen months. The offensiA'^e and powerful odour which char- acterizes this plant is not peculiar to it. The fruit of some of the North American currants, and particularly Mihes rigens of Michaux, a species often met with on the high mountains of the East- ern States ; emits when bruised a scent exactly similar to this vegetable. The odour of the Ictodes resides in a princi- ple which is extremely volatile. I have not been able to separate it by distillation from any part of the plant, the decoction and the distilled water be- 46 ICTODES lOETIDUS. ing in my experiments but slightly impregnated with its sensible character. Alcohol, digested on the plant, retains its odour for a time, but this is soon dissipated by exposure to the air. An acrid principle exists in the root even when perfectly dry, producing an effect like that of the Arum and Ranunculi. When chewed in the mouth, the root is slow in manifesting its pe- culiar taste ; but after some moments, a pricking sensation is felt, which soon amounts to a disa- greeable smarting, and continues for some time. This acrimony is readily dissipated by heat. The decoction retains none of it. The distilled water is impregnated with it, if the process be carefully conducted, but loses it on standing a short time. A resinous substance is dislodged from the alcoholic solution of the root by the addition of water, the solution becoming moderately turbid. A gummy or mucous principle is also present, and fills the mouth with mucilage when the root is chewed. It is separated from the decoction in sinsil Jiocculi when alcohol is added. The spadix consists of a fleshy cellular sub- stance, which shrinks very much in drying. The seeds when dry are reduced to half their former size, and in this state they have a tough waxy SKUNK CABBAGE. 47 eonsistence and an animal odour. They contain fixed oil in abundance, which is easily forced out from them by expression. Their principal bulk appears to be albumen, and when reduced to powder they are less easily soluble in boiling water, than grains which are less oleaginous. They burn with an oily smoke, leaving behind a large coal. The sensible properties of the Ictodes having a strong ajQinity with those of assafcetida and tJie other foetid gums, practitioners have been led to expect from it a similar antispasmodic power. Experience has justified these expectations in a variety of disorders of the spasmodic and nervous kind. The Eev. Dr. Cutler of Massachusetts was the first who recommended its use in asth- matic cases. In his account of indigenous Amer- ican vegetables, he tells us that the roots dried and powdered form an excellent remedy in asthma, and often give relief when other means prove in- effectual. It may be given, he says, with safety to children as well as adults ; to the former in dos- es of four, ^\e or six grains, and to the latter in doses of twenty grains and upward. In a private letter he states, that he made use of it in his own case of asthma for several years, and generally found relief. Jn the winter he used the dried 48 ICTODES FffiTIIiUS. root in powder, and in summer, the fresh grated root. It continued to afford more reUef than any other remedy, so long as the paroxysms remain- ed under the influence of any medicine. Since the recommendation of Dr. Cutler, many country physicians have employed the root in asthma, catarrh and chronic coughs, with evident benefit. A number of cases have fallen under my own ob- servation of the catarrh affections of old people, in which a syrup prepared from the root in substance has alleviated and removed the complaint. Dr. Thacher informs us on various authorities, that the powdered root has given immediate relief in hysteric paroxysm, that it has afiected the cure of dropsy, and that rheumatic patients have found great benefit from its use. Its strong and pene- trating acrimony would lead us, a priori, to ex- pect advantage from it in these complaints. Even in the more formidable disease of epilepsy, it has appeared to do good. Some caution, however, is requisite in its man- agement, as serious inconvenience may ensue from an over dose. In delicate stomachs I have found it frequently to occasion vomiting even in a small quantity. In several cases of gastrodynia where it was given with a view to its antispas- modic effect, it was ejected from the stomach SKUNK CABBAGE. 49 more speedily than common cathartic medicines. I have known it in a dose of thirty grains to bring on not only vomiting, but headach, vertigo and temporary blindness. Other practitioners have given it in larger quantities witliout any evil of this kind, but I think such an exemption must be attributed to the age and deteriorated quality of the root. Its active ingredients being more or less volatile, it must necessarily be impaired in strength by long keeping, especially in a pulveriz- ed state. To insure a tolerably uniform activity of this medicine, the root should be kept in dried slices and not reduced to powder until it is wanted for use. It may then be taken in pills or mixed with syrup in doses of from ten to twenty grains. These may in most instances be repeated three times a day. BOTANICAL REFERENCES. Arum Americanum, Catesbt, Car. ii. i. 71. — Dracontium foetidum, Lin. Stjst. pi. — Willd. ii. 288. — Pothos fosfida, Mi- CHAUx, Amer, ii. 186. — Pursh, ii. 398. — Bot. Mag. 836. — Sym- plocarpus foetida, Nuttaxi, genera, i. 105. MEDICAL REFERENCES. Cutler, Trans, Amer, dead, 1. 407". Thachee, Dispensa- tory , 150. 50 ICTODES FCETIDUS. PLATE XXIV. Fig. 1. Modes fodidus injlower, the spathe inclosing the €padix» Fig. 2. The spadix taken out of the spathe* Fig. 3. The leaves, stalkSf <^c. Fig. 4. The spadix in fruity one quarter heing cut away to show the seeds. Fig. 5. djlower magnified. Fig. 6. The same opened. Fig. 7. Petal and Stamen* Fig. 8. Style, Fig. 9, 10. Seeds. .r J' 1 /i^a^ff^f STATICE CAROLINIANA. Marsh Mosemary, FLATE XXV. HE class of vegetables, denominated mari- time, or sea shore plants, are constituted to occupy extensive tracts of ground, which, from their im- pregnation with sea salt, are incapable of sustain- ing the life and growth of other species. The mu- riate of soda, if poured at the roots of the most vigo- rous plants belonging to a fresh soil, will often de- stroy them in a short time. Few forest trees of the temperate zones can grow in marshes where their roots are wholly exposed to the access of salt wa- ter. Yet such is the wise arrangement of nature, that this substance, which proves a poison to most vegetables, is converted into the food and necessa- ry stimulus of the rest. Maritime plants flourish alike in places visited by the tide, and those ira- S2 STATICE CAROLINIANA. pregiiated by the salt springs of the mterior. The degree in which they require the presence of the mineral is various, some growing upon the beach, where the earth is saturated with salt, and others at the extreme edge of marshes, where the impreg- nation is much less powerful. With a few excep- tions, they cannot long be cultivated in fresh earth, but soon decay when removed from their native marshes. Maritime plants derive a peculiar character from their place of growth, which distinguishes them even when dry from other vegetables. The salt with which they are impregnated crystallizes on their surface in dry weather ; and deliquesces so as to render them damp and supple, when the atmosphere is moist. These plants are trouble- some in an herbarium from the facility with which they contract moisture from the atmosphere, and communicate it to the adjacent papers. The hay cut upon salt marshes often becomes extremely damp, and would be entirely spoiled, were it not for the antiseptic and preservative quality of the salt. The barilla of commerce is obtained by the combustion of maritime vegetables. Many of these plants are thick and fleshy in their mode of growth, and differ remarkably in this res- pect from their co-species on dry ground. This is MARSH ROSEMARY. 53 particularly seen in Arenaria, Gerardia, Chenopo- dium, ^c. The vegetable wliich is the subject of this ar- ticle is exclusively a maritime plant. It is one of the few ornamental species in our salt marshes, and is very conspicuous for its purple tops ap- pearing among the grass in all the summer months. It varies from a few inches, to a foot and more in heischt. This species has generally been considered a variety of the Statice limonmm, which is a com- mon plant in the salt marshes of Europe. In- deed, several of the maritime species of this genus approach each other so closely in their characters, that they have been considered the same by able botanists. The American plant, to which the name of Caroliniana was given by Walter in his Flora of Carolina, is distinguished from the Eu- ropean principally by its smaller ilowers and plain or flat leaves. From the Statice Gmelini, an Asiatic species, it differs appp^rently still less in its general form. The genus Statice belongs to the class Pentan- dria and order Pentagynia, Its natural orders are Aggregatce of Linnseus and Pliimhagmes of Jussieu. It is characterized by a cahjx mono- phyllous^ plaited and scarioiis. Petals jive with 54 STATICE CAROLINIANA. the Stamens inserted in their claws. Seed one^ in- vested with the calyx. The species Caroliniana has its scape round and panicled ; its leaves oho- vate-lanceolate, smooth, obtuse, mucronated, and flat on the margin. The root of this plant is perennial, large, fleshy, fusiform or branched. Several tufts of leaves and scapes are often produced from the same root. The leaves are narrow-obovate^ sup- ported by long petioles, smooth, veinless, obtuse, mucronated by the prolongation of the middle rib, level and flat on the margin, in which respect they difier from S. limonium, which is undulated. Scape round, smooth, furnished with a few scales, flexuous at top, giving off numerous branches, which end in spikes of flowers ; the whole form- ing a large panicle. The base of each branch and flower is supported by an ovate, mucronated scale. The flowers are alternate, erect, consequently one sided in the horizontal branches ; mostly in pairs, but appearing single from one expanding before the other. They grow on a short, forked pedun- cle, which is concealed by several sheathing scales, part of which are common to the two, and part peculiar to the upper one. The calyx is funnel shaped, five angled, the angles ciliate and end- ing in long acute teeth with sometimes, not al- MARSH ROSEMARY, 55 ways, minute intermediate teeth. Tlie upper part of the calyx is scarious and of a pink colour. Petals spatulate, obtuse, longer than the calyx, pale bluish purple. Stamens inserted in the claws of the petals, anthers heart shaped. Germ small, obovate, with five ascending styles shorter than the stamens. Seed oblong, invested with the persistent calyx. The root, which is the officinal part of the Marsh Rosemary, is one of the most intense and powerful astringents in the vegetable materia medica. It communicates to the mouth an high- ly austere and astringent taste, combined with a good deal of bitterness. Few vegetable substan- ces, when chemically treated, give more distinct and copious evidence of the presence of both tannin and gallic acid. The sulphate of iron strikes a fine purple colour with the solution, and soon deposits a precipitate, which, on expo- sure to the air, becomes of an inky blackness. Gelatin also throws down a copious, whitish, in- soluble precipitate. Resin hardly exists in this root, nor any thing else exclusively soluble in al- cohol. The impregnation with sea salt is readily made obvious. Dr. Mott, Professor of Surgery in the Univer- sity of New York, has published an interesting 06 STATICE CAROLINIANA. and valuable iavestigation of the properties of this plant in 1806. He informs ns that the astringen- cy, indicated by the sulphate of iron, was greater in the tincture than in the infusion under experi- ments precisely similar ; from which it may be inferred, that alcohol is a better solvent for this root than water. He also found the cold infusion more powerful than the hot, a circumstance prob- ably to be accounted for by the escape of a part of the gallic acid by evaporation. The astringen- cy w as found fully equal to that of galls, and ink made from equal quantities of the two, similarly treated, was equal in blackness. The Statice Caroliniana possesses much me- dicinal reputation as an astringent, and large quantities of it are annually consumed in different parts of the United States. In Boston it is reg- ularly kept by the druggists, and larger quantities are sold, than of almost any indigenous article. It is principally sought for as a topical remedy in aphtha and other ulcerative affections of the mouth and fauces. From its astringent and an- tiseptic quality, it is peculiarly suited to correct the state of these local maladies, and its applica- tion is commonly followed with success. It is much better suited to such complaints than the Coptis trifolia or gold thread, with which it is MARSH ROSEMARY, 57 frequently combined, and which is only a tonic bitter without astringency. Dr. Baylies of Dighton, Mass. emplojed a de- coction of the root, both internally and externally, in the Cynanche maligna, a disease which has at times been epidemic and very destructive in dif- ferent parts of our country. It proved very suc- cessful not only under his own observation, but under that of other physicians in this dangerous complaint. Dr. Mott informs us, that in the chronic stages of dysentery, after tlie inflammatory diathesis, great tenesmus, 6)'c. are removed ; a strong de- coction of the root has restored patients to health, after various tonics and astringents had been used to no effect. « BOTANICAL REFERENCES. Statice Caroliniana, "Walter, Flora Car. 1 1 8. — Pursh, i. 212. — NuTTALL, i. 206. — Statice limoniiim, Muhlenberg, Cat- aloguCf 33. — Elliott, Carolina, i. 874. MEDICAL REFERENCES. Mott, Inaugural Dissertation. — Thacher, Disp, 345. — Bay- lies, Papers of the Mass. Med, Society, vol. i. 8 58 STATICE CAROLINIAlifA. PLATE XXV. Fig. 1, Statice Caroliniana, '% Fig, 2. Jl Jlower magnified. Fig. 3. Calyx ditto, '"' Fig. 4. A petal and stamen ditto. Fig. 5, 6rerni and styles ditto. MV MM^-^ ASCLEPIAS TUBEROSAe Buttevfiy Weed, PLATE XXVI, F Ew genera are more curious and intricate in their structure, than that to which our present article belongs. The plants which constitute the family of Asclepias are so peculiar in their habit, that they are easily recognized even by the inex^ perienced botanist, while their minute structure is so complicated, as to require not a little atten- tion for its perfect development. This fine race of plants are so abundant in the United States, that every month of the summer season presents us a number of beautiful species. By far the most rich and gaudy of these in appearance is the Asclepias tuberosa, known by the vulgar names of Biittevjly weed and Fleurisy rooty and found in dry, sandy soils, pine woods, §c. from Massachu- 60 ASCLEPIAS TURBEROSA, setts' to Georgia. It is the Asclepias decumbens of Walter. This genus has a Jive parted calyx ; a five parU ed vefieoced corolla ; a nectary of five erect, ciicul- late leaves, each producing an iifiected horn from its cavity ; stamens united, with ten pollen masses hanging by pairs in their cavities. The species tuberosa is hairy, its leaves alternate, oblong-lance- olate ; its branches cymose. Class Pentandria, order Bigynia, Natural or- ders Contortas, L. Apocinece, Juss. The root of this plant is large, fleshy, branch- ing, and often somewhat fusiform. It is only by comparison with the other species that it can be called tuberous. The stems are numerous, grow- ing in bunches from tlie root. They are erect, ascending or procumbent, round, hairy, green or red. Leaves scattered, the lower ones peduncu- lated, the upper ones sessile. They are narrow, oblong, hairy, obtuse at base, waved on the edge, and in the old plants sometimes re volute. The stem usually divides at top into from two to four branches, whicli give off crowded umbels from their upper side. The involucrum consists of nu- merous, short, subulate leafets. Flowers nume- rous, erect, of a beautifully bright orange colour. Calyx much smaller than the corolla, five parted, BUTTERFLY WEED. 61 the segments subulate, reflexed and concealed by the corolla. Corolla five parted, reflexed, the seg- ments oblong. The nectary or stamineal crown is formed of five erect, cucullate leaves or cups, with an oblique mouth, having a small, incurved, acute horn proceeding from the base of the cavity of each and meeting at the centre of the flower. The mass of stamens is a tough, horny, somewhat pyramidal substance, separable into five anthers. Each of these is bordered by membranous, reflect- ed edges contiguous to those of the next, and ter- minated by a membranous, reflected summit. In- ternally they have two cells. The pollen forms ten distinct, yellowish, transparent bodies, of a flat and spatulate form, ending in curved filaments, which unite them by pairs to a minute dark tuber- cle at top. Each pair is suspended in the cells of two adjoining anthers, so that if a needle be in- serted between the membranous edges of two an- thers and forced out at top, it carries with it a pair of the pollen masses. Pistils two, completely con- cealed within the mass of anthers. Germs ovate, with erect styles. The fruit, as in other spe- cies, is an erect lanceolate follicle on a sigmoid pe- duncle. In this it is green, with a reddish tinge and downy. Seeds ovate, flat, margined, connect- ed to the receptacle by long silken hairs. Recep- tacle longitudinal, loose, chaffy. 62 ASCLEPIAS TUBEROSA. The down or silk of the seeds, in this and oth- er species, furnishes an admirable mechanism for their dissemination. When the seeds are liberat- ed by the bursting of the follicle which contains them, the silken fibres immediately expand so as to form a sort of globe of branching and highly attenuated rays, with the seed suspended at its cen- tre. In this state they are elevated by the wind to an indefinite height, and carried forward with a voyage like that of a balloon, until some obstacle intercepts their flight, or rain precipitates them to the ground. The down of different species of Asclepias is susceptible of application to various useful and or- namental purposes. If the fibre were sufficiently long to admit of its being woven or spun, it would ap- proach more closely to silk in its gloss and texture, than any vegetable product we possess. As it is, it has been substituted for fur, in the manufacture of hats, and for feathers in beds and cushions, "When attached by its ends to any woven fabric, this down forms a beautiful imitation of the finest and softest fur skins, and is applicable to various purposes of dress. The Asclepias Syriaca, from its frequency and the large size of its pods, has been most frequently employed for the foregoing purposes. [JVofe A.] BUTTERFLY WEED. 63 The root of the Butterfly weed when dry is brittle and easily reduced to powder. Its taste is moderately bitter, but not otherwise unpleasant. Its most abundant soluble portions are a bitter ex- tractive matter and fsecula, iKTo evidence of as- tringency is afforded on adding solutions of isin- glass or copperas, and hardly any traces of resin on adding w ater to alcohol digested on the root. The decoction afforded a flaky precipitate to alco- hol, when the infusion did not. Boiling water may be considered the proper menstruum for this plant. This fine vegetable is eminently intitled to the attention of physicians as an expectorant and dia- phoretic. It produces eff'ects of this kind with great gentleness, and without the heating tenden- cy which accompanies many vegetable sudorifics. It has been long employed by practitioners in the Southern States in pulmonary complaints, particu- larly in catarrh, pneumonia and pleurisy, and has acquired much confidence for the relief of these maladies. It appears to be an expectorant pecu- liarly suited to the advanced stages of pulmonary inflammation, fifter depletion has been carried to the requisite extent. Dr. Parker of Virginia, as cited by Dr. Thacher, having been in the habit of employing this root for twenty five years, cojjsid- 64 ASCLEPIAS TUBEROSA. ers.it as possessing a peculiar and almost specific quality of acting upon the organs of respiration, promoting suppressed expectoration, and relieving the breathing of pleuritic patients in the most ad- vanced stage of the disease. Dr. Chapman, Professor of medicine in Phil- adelphia, informs us that his experience with this medicine is sufficient to enable him to speak with confidence of its powers. As a diaphoretic he thinks it is distinguished by great certainty and permanency of operation, and has this estimable property, that it produces its efiects without in- creasing much the force of the circulation, raising the temperature of the surface, or creating inqui- etude and restlessness. On these accounts it is well suited to excite perspiration in the forming states of most of the inflammatory diseases of winter, and is not less useful in the same cases at a more advanced period, after the reduction of ac- tion by bleeding, §c. The common notion of its having a peculiar efficacy in pleurisy, he is inclin- ed to think is not without foundation. Certain it is, says he, that it very much relieves the oppres- sion of the chest in recent catarrh, and is unques- tionably an expectorant in the protracted pneu- monies. BUTTERFLY WEED. 6d As far as my own observation with this plant extends, I am persuaded of its usefulness in va- rious complaints. It appears to exert a mild ton- ic effect, as well as a stimulant power on the ex- cretories. Like other vegetable bitters, if given in large quantities, especially in infusion and de- coction, it operates on the alimentary canal, though its efficacy in this respect is not suffi- cient to entitle it to rank among active cathartics. I am satisfied of its utility as an expectorant med- icine, and have seen no inconsiderable benefit arise from its use as a palliative in phthisis pul- monalis. Among other instances may be cited that of a young physician in this town, who died two years since of pulmonary consumption. He made great use of the decoction of this root, and persevered in it a long time from choice, finding that it facilitated expectoration and relieved the dyspnoea and pain in the chest, more than any other medicine. The best mode of administering the Asclepias is in decoction or in substance. A teacup full of the strong decoction, or from twenty to thirty grains of the powder, may be given in pulmonary complaints several times in a day. In most cases after the inflammatory diathesis is in some degree subsided, it may be freely repeated as long as it agrees with the stomach and bowels. 9 66 ASCLEPIAS TUBEROSA. BOTANICAL BEFERENCES. Asclepias tuberosa, Lin. Sp. pL — Pursh, i. 183. — Michaux, i. 117. — Elliott, Car. i. 325. — Asclepias decumbens, a variety, Lin. Pursh, &c. — Apocynum Novse Anglise hirsutum radice tuberosa, floribus aurantiacis, Herman, HorL 646. U 647. — DiL- lENius, Elth. S5, t. 30, /. 34. MEDICAL REFERENCES. B. S. Barton, CoUectionSf 48. — Thacher, Disp, 154.— Chapman, Therapeutics and Mat. Med. i. 346. PLATE XXVI. Fig. 1, Asclepias tuherosa. Fig. 2. Jl fiotver. Fig. 3. Jljiower dissected, showing the iviass of anthers, undone nectary with. its horn. Fig. 4. Magnified section of the mass of anthers, showing the sit- iiation of the pistils itiside, ^c. A pair of pollen masses is drawn out at the top. Fig. 5. Fistils magnified, and calyx. JCXV21 MAGNOLIA GLAUCA, Small Magnolia. PLATE XXVIL \3y the splendid family of trees known by the name of Magnolia, the American continent lias many species. Taken collectively they fur- nish perhaps the most elegant assemblage produc- ed in the forests of the temperate zone. They are distinguished by their rich, smooth foliage, large fragrant flowers, and aromatic bark. Some of them are trees of very exalted stature, taking rank with the highest tenants of the woods. The present species is more humble than the rest in its growth, yet more interesting in some of its oth- er properties. The Magnolia glauca has the most extensive range, especially near the sea board, of any of the species of its family. Its most northern bounda- 68 MAGNOLIA GLAUCA. ry appears to be in a sheltered swamp in Man- Chester, Cape Ann, about thirty miles north of Boston. It here attains to but small size, and is frequently killed to the ground by severe winters. It is common in the Middle and Southern States, and Michaux informs us, that it is one of the most abundant trees in the morasses of Florida and Lower Louisiana. According to this author how- ever, it is not usually met with far in the interior, or to the west of the mountains. Its common names are various, and change with almost every district. In Massachusetts it has no other name than Magiiolia ; in the Middle States it is called Swamp sassafras and Beaver tree ; while in the Southern States it is denominated Sweet hay and White hay. It is naturally a tenant of deep boggy swamps, and is somewhat irregular in its growth. It acquires more symmetry of form when cultivat- ed in an upland soil, although its transplantation is difficult. To insure it sussessful cultivation in a dry soil, the tree should be raised from the seed. This tree begins to flower in different parts of the United States in May, June and July. The flowers are highly fragrant, and may be perceived by their perfume at a considerable distance. A few of them shut up in a room over night commu- nicate to the air a heavy and almost insupportable odour. SMALI. MAGNOLIA. 69 The Magnolias are found in the class Folyan- dria and order Polygynia ; the Coadunatas of Lin- naeus and Magnoliw of Jussieu. This genus has a calyx of three leaves, a co- rolla of six petals or more ; capsules two-valved, imbricated, forming a cone ; seeds berried, pendu- lous. The present species has oval leaves, glaucous underneath ; and obovate petals, narrowed at base. The bark of the young twigs is of a bright, smooth green, with rings at the insertion and scars of the leaves. The leaves are scattered, petioled, regularly elliptical, entire, and glabrous. Their under side, except the midrib, is of a beautifully pale, glaucous colour, by which the tree may be distinguished at a distance. When young, this surface is covered with a silken pubescence. Flow- ers solitary, terminal, on a short, incrassated pe- duncle. Calyx of three spatulate, obtuse, concave segments. Corolla of from eight to fourteen obo- vate, obtuse, concave petals, contracted at tlieii' base. The stamens are very numerous and in- serted in common with the petals on the sides of a conical receptacle. Filaments very short ; an- thers linear, mucronated, two-celled, opening in- wardly. Germs oval, collected into a cone, each one divided by a furrow and tipt with a brownish, yQ MAGNOLIA GLAUCA. linear, recurved style. The fruit is a cone, con- sisting of imbricated cells, which open longitudi- nally for the escape of the seed. The seeds are obovate, scarlet, connected to the cone by a thread, which suspends them some time after they have fallen out. The bark of the Magnolia glauca has a bit- ter taste, combined with a strong aromatic pun- gency, which approaches that of Sassafras and of the Acorns calamus. The aroma resides in a vol- atile portion, which is probably an essential oil, or a variety of camphor. It is lost from the bark in the dry state, after it has been kept some time. Water distilled from the green bark has its pecu- liar flavour with an empyreumatic smell. No oil appears on the surface, when the experiment is conducted in the small way. The dried bark af- fords a little resin, and more of a bitter extractive substance. Chalybeate tests produce a very slight darkening of the green colour of the decoction, but gelatin occasions no change. This might be anticipated from the little taste of astringency in the bark. As a medicinal article, the Magnolia is to be considered an aromatic tonic, approaching in its charactertoCascarilla, Canella, and articles of their class. Considered simply in regard to its tonic SMALL MAGNOLIA. ' 71 powers, it is probably of a secondary order, though from the additional properties which it possesses of a warm stimulant and diaphoretic is found use- ful in certain disorders. Chronic rheumatism is one of the diseases in which it exhibits most effi- cacy. Not only the bark, but tlie seeds and cones which are strongly imbued with the sensible qual- ities of the tree, are employed in tincture with very good success in this disease. In intermittent and remittent fevers the Mag- nolia is one of the many tonics which have been resorted to for cure by the inhabitants of the marshy countries where they prevail. Sufficient testimony has been given in favour of the bark of this tree, to warrant a belief that it is fully ade- quate to the removal of fever and ague, when ad- ministered like the Cinchona, in liberal quantities between the paroxysms. In the more continuous forms of fever of the typhoid type, it has also re- ceived tile commendations of physicians. Several other species of Magnolia resemble the present very closely in their sensible properties, and as far as experiments have been tried, they are similar in their medicinal effects. In order to secure the whole efficacy residing in these trees, a tincture should be made from the bark or cones while green or very recently dried, before their more volatile parts have escaped. 72 MAGNOLIA CJLAUCA. BOTANICAL REFERENCES. Magnolia glauca, Liiv. Sp. pi.— Michaux, i. 323. — Ptjrsh, ii. 381. — ^MicHAux, rix. Arb. foresU iii. 77. — Magnolia lauri folio subtus albicante. Catesbt, Car. i, t. 39. — Trew, sel. t. 9. — DiLLENius, Rort. £0r. 1 168, /. 205. — Laurus tulipifera &c. — Raius, hist. 1690. MEDICAL REFERENCES. Kaim, Travels, i. 205. — Marshall, Arbustum, 83. — ^Hum- phries, Med. Commentaries^ vol. xviii. — Bart. Coll. 46. — Price, Inaugural Diss. Philad. 1812. PLATE XXVII. Fig. 1. .R flowering branch of Magnolia glauca. Fig. 2. The fruit and seeds. Fig. 3. Stamen magnified. Fig. 4, A germ and style ditto. pi.xzvin. COBNUS FLOEIDA. Logwooih PLATE XXVlIh T HE family of Cornels, if surveyed bj oth- er eyes than those of botanists, is remarkable for the difference of growth and appearance of its various species. Many of them are shrubs ; a few attain to the stature of trees, while some are so humble in their growth as to be deemed hardly more than herbaceous. A part have their flowers surrounded with a fine white involucrum, many tioies exceeding the whole bunch in magnitude 5 while others present their naked cymes unadorn- ed by any investment. To the botanical observer they all exhibit a close affinity and resemblance to each other ; which is seen in the form and anatom- ical texture of their leaves, the structure of their flowers and the appearance of their fruit, 10 74 CORNCJS FLORIDA. The Cormis florida, or flowering Dogwood, is the largest and most splendid of its genus, and is one of the chief ornaments of our forests. As a tree it is rather below the middle stature, not usually reaching the height of more than twenty or thirty feet. It is however among the most conspicuous objects in the forests, in the months of April, May and June, according to its latitude, being then covered with a profusion of its large and ele- gant flowers. In Massachusetts, especially about Boston, it is not a common tree, only scatter- ed individuals appearing here and there in the woods. In the Middle States it is extremely com- mon, especially in moist woods. Michaux informs us, that in the Carolinas, Georgia and the Floridas it is found only on the borders of swamps, and never in the pine barrens, where the soil is too dry and sandy to sustain its vegetation. It is al- so not very common in the most fertile parts of the Western States, being chiefly found where the soil is of secondary quality.* * Mr. William Bartram, in his travels in Georgia and Floridajgives the following account of the appearance of this tree near the banks of the Alabama river. *' We now entered a very remarkable grove of Dogwood trees, f CornusJiorida,J which continued nine or ten miles unalterable, except here and there a towering Magnolia grandijiora. The land on which they stand is an exact level ; the surface a shallow, loose, black mould, on a stratum of stiff, yellowish clay. These trees -% DOGWOOD. 75 The genus Cornus is characterized by the fol- lowing marks. Petals four, superior ; involucriun of four leaves, or wanting ; drupe with a two-cell- ed nut. The species ^oWdrt is arboreous, with its flozvers in heads surrounded by an involucmim of obovate leaves with recurved points. Class Tetandria, order Monogynia, natural or- der Stellatoe, Lin, Caprifolia. Juss. The Cornus florida is of slow growth, and pos- sesses a very compact wood, covered with a rough, broken bark. The branches are smooth, covered with a reddish bark, marked with rings at the place of the former leaves. The leaves, which are small at the flowering time, are opposite, peti- oled, oval, acute, entire, nearly smooth, paler be- were about twelve feet high, spreading horizontally, their limbs, meet- ing and interlocking with each other, formed one vast, shadj, cool grove, so dense and humid as to exclude the sun-beams, and prevent the intrusion of almost every other vegetable, aflfording us a most de- sirable shelter from the fervid sun-beams at noon day. This admi- rable grove has by way of eminence acquired the name of Dog woods. During a progress of near seventy miles through this high forest, there constantly presented to view, on one hand or the other, spa- cious groves of this fine flowering tree, which must in the spring sea- son, when covered with blossoms, present a most pleasing spectacle, when at the same time a variety of other sweet shrubs display their beauty ; as the Halesia, Stewartia, ^sculus. Azalea, &c. en- tangled with garlands of Bignonia, Glycine, Lonicera, &c. &c. at the same time the superb Magnolia grandiflora standing in front of the dark groves, towering far above the commoa level." Travels, p. 399. 76 CGRNTJS FLORIDA. neath, and marked, as in others of the genus, with strong parallel veins. The flowers, which are very small, grow in heads or sessile umbels, upon peduncles an inch or more in length. At the base of each bunch is the large spreading involu- crum,constitatingthe chief beauty of the tree when in flower. This involucrum is composed of four white, nerved, obovate leaves, having their point turned abruptly down or up, so as to give them an obcordate appearance. This point has frequently a reddish tinge. Calyx superior, somewhat bell- shaped, ending in four obtuse spreading teeth. Petals four, oblong, obtuse, reflexed. Stamens four, erect, the anthers oblong with the filaments inserted in their middle. Style erect, shorter than the stamens, with an obtuse stignua. The fruit is an oval drupe of a glossy scarlet colour, containing a nucleus with two cells and two seeds. The bark of the Cornus florida is a powerful bitter, possessing also an astringent and somewhat aromatic taste. Both tannin and the gallic acid are abundantly developed in its solutions by their proper tests. In my experiments with the bark of young twigs, but a small quantity of pure resin was made manifest. It would seem that the prin- cipal seat of the bitterness is in a variety of ex- tractive matter. DOGWOOD. 77 In a valuable inaugural dissertation on tlie CornuS florida and Cornus sericea by Dr. Walker of Virginia, much attention appears to have been bestowed on the chemical properties of their bark. He found that water distilled from the bark in powder had a transparent, whitish appearance, with a slight aromatic odour, and no perceptible taste. When the heat was increased, the fluid had a lemon colour, with an unpleasant smell and an acerb taste. These effects were probably pro- duced by the volatilization and partial decompo- sition of portions of the bark in consequence of the heat being continued until the mixture was evaporated nearly to dryness. With a view to ascertain the effect of different menstrua. Dr. Walker subjected to experiment the residual mass furnished by evaporating a decoc- tion of the root of Cornus florida. Two drachms of this residuum, which had been furnished by seven and an half ounces of the decoction, were macerated in successive quantities of the best al- cohol, until the last portion ceased to be changed in colour and taste. The part, which remained undissolved, weighed only half a drachm. When redissolved it was destitute of taste, and underwent no change of colour on adding the test of iron. The alcohol, which had been employed in the ex- 78 CORNUS FLORIDA. periment, was found to possess an intensely bitter taste with astringency, of a clear red colour, and turning to a deep black on the addition of iron. On evaporation, it yielded a drachm and an half of residuum. — Dr. Walker attempted to ascertain the quantity of resin by macerating the alcoholic ex- tract in repeated portions of sulphuric ether. The ether acquired a dark colour and a bitter taste, and was found to have dissolved three quar- ters of the extract. When tested with iron, it was found that the remaining quarter only was chang- ed to a black colour. The Cornus florida is one of the many vege- tables wliich, by the union of their gallic acid with the salts of iron, form a black compound, applica- ble to the purposes of ink. The constancy of the black colour thus produced varies greatly, ac- cording to the substance from which the gallic acid is derived. It is often extremely fugacious, sometimes fading in a few days, and at others be- coming indistinct after some weeks or months. Considering the very great importance of the pur- poses for which ink is employed, and the immense evils which may result from its obliteration in writ- ings intended for permanency ; it is with extreme caution that we should recommend the introduction of any change in the mode of its formation. The DOGWOOD. 79 oak gall has had the experience of ages in favour of its permanence and immutability. It is not until some indigenous article, producing au equal intensity of colour, has undergone a series of tri- als from time and exposure, sufficient to establish beyond a doubt its durability, that its substitution in the manufacture of ink should be considered expedient or even justifiable. Upon the human body the bark of the Cornus florid a acts as a tonic, an astringent and an anti- septic, approaching in its general effects to the character of the Peruvian bark. From a variety of experiments made by Dr. Walker upon the healthy system, it was found that this medicine uniformly increased the force and frequency of the pulse, and augmented the heat of the body. Collateral experiments were made at the same time with the Peruvian bark, with which the Cor- nus appeared to agree both in its internal and ex- ternal effects. In disease it has been principally employed in the same cases for which the cinchona is resorted to, particularly intermittent and remittent fever, iJr. Gregg of Pennsylvania, cited by Dr. Walker, states, that after employing the Cornus florida ha- bitually for twenty three years in the treatment of iiitermittents, he was satisfied that it was not in- BO CORNLS FLORIDA, ferior to the Peruvian bark as a means of care ia such cases. Among the number of cures by this medicine, was tliat of his own case. He observ- ed that in its recent state it sometimes disagreed with the stomach and bowels, but that this ten- dency in the article was corrected by age. He recommends the bark as being in the best state after it has been dried a year. Other medical men have employed the bark of this tree with advantage in intermittents, and also in continued fevers of the typhoid type. Its tonic operation in these cases appears very analo- gous to that of the Peruvian bark. I have employed the tincture of Cornus flori- da as a stomachic in various instances of loss of appetite and indigestion. The report of those who have taken it has perhaps been as frequently in favour of its effects, as of gentian, columbo, and the other imported tonics of the shops, though perhaps it is somewhat more liable to offend the stomach in large doses. In the Southern States a decoction of the buds and twigs has been thought to agree better with weak stomachs, than the oth- er preparations. Some other species of this family resemble the present tree in the bitterness and tonic power of tlieir bark, particularly the Cornus circinata and C. sericea. i30GW00D. 81 The wood of the Cornus florida is hard, heavy and fine grained, and susceptible of a good pol- ish. It is employed for various purposes where strength and solidity are required, although its small size does not permit it to be used for ob- jects of much magnitude. From its hardness it is found peculiarly useful for handles of instru- ments, the teeth of wheels, and the smaller parts of wooden machinery. BOTANICAL REFERENCES. Conius florida, Liw. Sp.pl. — Gron^ovitjs, Virg. 17.— -Kaxm, •travels, ii. 321. — Wastgenheim, Amer. p. 51, t. 17. — L'Heri- TiEE, Corn, n. 3.— Schmidt, Jirh. t. 62 — Botanical Mag. t. 526. — -PuRSH, i. 108. — ^MiCHAUx, FiL. ArbresforestierSs iii. 138, trans- latedf i. 255. — Eliiott, Car. i. 207. — Cornus mas Virginianaj kc. — .Pltjkenet, Mm. 120, t. %J. 3. — Catesby, Car. t. 27. MEDICAL REFERENCES. -Walkee, Inaugural Disseftatmh Philail. 1303. — EAFiT. Colt. 12. — .THACHEa, Disp. 203. — Elliott, ut supra. ■ PLATE XXVIII. Fig, 1. Cornus fiorMa, a braiidi witlijiowers, and one with havts. Fig. 2. Fruit. Fis:. S. A Hower. PA]^Ax auiisrauEFOLimi. Ginseng. TLJITE XXIX. N the early part of the eighteenth century some accounts were sent to Europe hy travellers and missionaries, of a root growing in Chinese Tartary, known by the name of Ginsengs upon which a \\m\\ value was set bv the eastern Asiat- ics, and which was sold in the cities of China at an enormous price. Father Jartoux, a missionary at Pekin, who had an opportunity of witnessing the collection and use of this root, made a drawing of the plant, accompanied with a particular descrip- tion, and an account of its uses, and the cause of its high estimation and demand among the Chi- nese. While on a journey among the mountains of Tartary, performed under the sanction of the emperor of China, he met in various instances GINSENG. 83 with the plant, and with people employed in col- lecting it. He states that the root is found prin- cipally between the 39th and 47th degree of north latitude, in thick forests, upon the declivities of mountains, on the hanks of torrents, and about the roots of trees. It never grows in the open plains or vallies, but always in dark, shady situa- tions, remote from the sun's rays. As the right of gathering this root is monop- olized by the emperor of China, the most exten- sile precautions are taken by him to prevent an encroachment on this privilege. The places where the Ginseng is known to grow are guarded with great vigilance, and a whole province, that of Q,uantong, bordering on the desert, is surround- ed by a barrier of wooden stakes, about which guards continually patrole, to keep the inhabitants within bounds, and prevent them from making excursions into the woods, in search of the pro- hibited drug. Notwithstanding this vigilance, their eagerness after gain incites the Chinese to wander by stealth in the desert, sometimes to the number of two or three thousand, in searcli of the root, at the hazard of losing their libert}, and all the fruits of their labour, if they are taken. The emperor employs his own servants for the pur- pose of collection, and in the year 1709, had ten 84 PANAX QUINQCEFOLIUM. thousand Tartars engaged in scouring tlie woods in pursuit of the plant. Each man so employed was obligated to present his majesty two ounces of the best he should collect, and to sell him the rest for its weight in pure silver. At this rate it was computed that the emperor would get in a year, about 20,000 Chinese pounds, which would cost him not above one quarter of its value, at the common rate of selling it. The collectors of the Ginseng carry with them neither tents nor beds, every one being sufficient- ly loaded with his provision, which is only parch- ed millet, on which he is obliged to subsist during the whole journey. The mandarins send them from time to time some pieces of beef, with such game as they happen to take, which they eat very greedily, and almost raw. They are accustomed to sleep on the ground, and notwithstanding six months are passed in this way, they continue lus* ty and in perfect health. The army of herbalists, in order to scour the country effectually, divide themselves into compa- nies of one hundred each, which proceed forward in direct line, every ten of them keeping at a dis- tance from the rest. In this way they overrun an extensive wilderness in a short space of time. GINSENG, 85 If any one of the company ^vas wanting, as it often happened, either hy having wandered oat of the way, or being attacked by wild beasts, the party devoted a day or two to search for him, and then returned to their labour. The root of the Ginseng is the only part pre- served. The collectors bury in the ground every ten or fifteen days all that they have procured. In order to prepare it for use, they dip it in scald- ing water, and scour it with a brush. The roots ai*e then prepared with the fumes of a species of millet, to give them a yellow colour. The millet is put in a vessel with a little water and boiled over a gentle fire. The roots are placed over the vessel upon transverse pieces of wood, being first covered with a linen cloth or another vessel. When treated in this way they assume upon dry- ing a horny or semi-trans parant appearance. The roots may also be dried in the sun, or by the fire, and retain their qualities perfectly. In this case, however, they have not that yellow col- our, which the Chinese so much admire. The Chinese consider the Ginseng as possessing unequalled medicinal powers, antl their physicians have written many volumes upon the qualities of the plant. It is made an ingredient in almost all the remedies which they ^ive to their nobility, its 86 PANAX QUINQUEFOLIUM. price being' too expensive for the common people* The sick take it to recover health, and the healthy to make themselves stronger and more vigorous. They affirm that it removes all fatigue, either of body or mind, dissolves humours, cures pulmona- ry diseases, strengthens the stomach, increases tlie vital spirits, and prolongs life to old age. [ts price at Pekin, according to travellers, has been eight or nine times its weight in silver, and even more. Father Jartoux became so far a convert to the virtues of the plant, that he tells us that after hav- ing taken half of a root, he found his pulse quick- er and fuller, iiis appetite improved, and his strength increased so as to bear labour better than before. On another occasion, finding liim- self so fatigued and wearied as to be scarce able to sit on horseback, a mandarin in company per- ceiving his distress, gave one of the roots. He took half of it, and in an hour was not sensible of any weariness. "I have observed," says he, " that the green leaves, especially the fibrous part of them, when chewed, would produce nearly the same effect. The Tartars often bring us the leaves of Ginseng instead of tea, and I always find myself so well afterwards, that I should read- ily prefer them before the best tea. Their de- GINSENG. 87" coction is of a grateful colour, and when one has taken it twice or tlmce, its taste and smell be- come very pleasant.'' The Chinese use a decoction of the root, for which they employ about a fifth part of an ounce at a time. This they boil in a covered vessel with two successive portions of water, in order to extract all its virtue. The following is the substance of Jartoux's de- scription of the Asiatic plant. The root is whit- ish, rugged and uneven. The stalk is round, and shaded with red ; it terminates in a knot or joint at top, from which proceed four equal branches. Each branch produces five leaves, which are equi- distant from each other, and from the ground. The leaves are unusually thin and fine, with their fibres very distinguishable, and a few whitish hairs on the upper side. Their colour is dark green above, and a pale, shining green underneath. All the leaves are serrated or finely indented on the edge, — From the centre of the branches rises a second stalk which is very straight and smooth, and whitish from bottom to top, bearing a bunch of round fruit, of a beautiful red colour, composed of twenty four red berries. The red skin of the berry is thin and smooth, and contains a white pulp. As these berries were double, (for they 88 PANAX Q.UINQ.UEPOLIUM. are sometimes found single,) each of tliem had two rough stones, separated from each other, of nearly the size and figure of common lentils. The herries were supported on small sprigs, •which rose from a common centre like the rays of a sphere. The fruit is not good to eat. The ber- ries are not round but a little flat on each side. When they are double there is a depression or hollow place in the middle where the two parts unite. Each berry has a small beard at top dia- metrically opposite to the sprig on which it hangs. When the berry is dry there remains only a shrivel- led skin, adhering close to tbe stones, of a dark red, or black colour. The plant dies away and springs up again every year. The number of years may be known by the number of stalks it has shot fortb, of which there always remains a mark or scar on the up- per pai't of the root. "As to the flower,'' says he, "not liaving seen it, I can give no description of it. Some say it is white and very small; others have assured me that the plant has none, and that nobody ever saw it. I rather believe that it is so small and so little remarkable, that none of tb.em ever took notice of it. GINSENG. 89 " There are some plants, Avhich, besides the bunch of berries, have one or two berries like the former, placed an inch or an inch and an half be- low the bunch. And when this happens, they say if any one takes notice of the point of compass to which these berries direct, he will not fail to find more of the plant." The foregoing description of Jartoux is intro- duced as being a very iotelligible description of a plant, in language not the most botanical. The drawing, which accompanies the description, is verv satisfactory. The report of the high value of the Ginseng at Peldn led to an inquiry among Europeans, wheth- er the plant was not to be found in parallel lati- tudes, in the forests of Xorth America. Father Lafiteau, a Jesuit, missionary among the Iroquois, after much search, found a plant in Canada an- swering the description, and sent it to France. In 17 18, M. Sarrasin published in the Memoirs of the Academy an account of the American Gin- seng ; which, together v. ith one published by Laf- iteau the same year, seemed to put its identity vdth the Chinese vescetable bevond a doubt. Soon after this the French commenced the collection of the root in Canada for exportation. For this purpose they employed the Indians. \v!io 12 90 PANAX QUINQUEJPOLIUM. brought it to tlie mercliants for a certain com- pensation. At one period the Indians about Que- bec and Montreal were so wholly taken up in the search for Ginseng, that their services could not be engaged for any other purpose. The Ameri- can English engaged in the same traffic, and al- though the plant is a rare one in the woods, yet very large quantities of the root were collected. In 1748, Kalm tells us the common price of the root at Quebec was from five to six livres a pound. The first shipments to China proved extremely profitable to those concerned, especially to the French. In a short time, however, the amount exported overstocked the market, the Chinese be- gan to think the American Ginseng inferior to the Tartarian, and its value depreciated, so that it ceased to be an object of profitable commerce. Its demand has not materially risen at any subse- quent period, although it is still occasionally ex- ported. The Chinese most readily purchase the forked or branching roots ; and those exporters have been most successful, who have prepared their Ginseng by clarifying it after the Chinese manner. The American Ginseng is thinly scattered throughout the mountainous regions of the North- ern and Middle States. Kalm informs us, that it GINSENG. 91 is seldom found north of Montreal. Miehanx states that it inhabits mountains and rich, shady woods from Canada to Tennessee. I have princi- pally met with this plant in the western parts of Massachusetts, and in Vermont, especially on the sides of the Ascutney mountain. Bertram found it near the mouth of the Delaware. Linnsgiis has given to the genus of plants, which includes the Ginseng, the name of Panacv^ a Greek word, intended to express the reputed character of the Chinese pcnicicea. The character of this genus consists in a sim- ple nmhel ; corolla jive petaUed; herry iiiferior, two or three seeded; plants polygamous . The species quinquefoUum has three qidnate lea.ves. The root of this plant consists of one or more fleshy, oblong and somewhat fusiform portions, of a whitish colour, transversely wrinkled, and ter- minating in various radicles. Its upper portion is slender and marked with the scars of the former shoots. Stem smooth, round, green, with often a tinge of red, regularly divided at top into three petioles, witli a flower-stalk at their centre. Peti- oles round, smooth, swelling at base. Leaves three, compound, containing five, rarely three or seven leafets. The partial leaf-stalks are given 92 PANAX QtllNQUEFOLIUM. off in a digitate manner, and are smooth, com- pressed and farrowed above. Leafets oblong, ob- ovate, sharply serrate, acuminate, smooth on both sides, with scattered bristles on the veins above. The flowers, which are small, grow in a simple umbel on a round, slender peduncle, longer than the petioles. The involucrum consists of a mul- titude of short subulate leafets, interspersed with the flower-stalks. These stalks or rays are so short as to give the appearance of a head, rath- er than umbel. In the perfect flowers the calyx has five small acute teeth ; the corolla five petals, "which are oval, reflexed and deciduous. Sta- mens five, with oblong anthers. Styles two, re- flexed, persistent ; germ large, inferior, ovate- heart shaped, compressed. The berries are kid- ney shaped, retuse at both ends, compressed, of a bright scarlet colour, crowned with the calyx and styles, and containing two semi-circular seeds. In most umbels there are flowers with only one style, in which case the berry has a semi-cordate form, as represented in fig. 3. Sometimes there are three styles and three seeds. The outermost flowers ripen first, and their berries often obtain their full size before the central ones are expand- ed. The middle flowers are frequently abortive. GINSENG. * 93 There are also barren flowers, on sepai'ate plants, which botanists describe as having hirger petals, and an entire calyx. I have not met with plants of this description in flower. The foregoing character leaves little donbt that the American plant is precisely the same with the Asiatic, although Loureiro and some oth- ers have disputed their identity. The description of Jartoux, which has been given, as well as his drawing of the plant, agrees in every respect, ex- cept that his plant had four branches or leaves, instead of three. This is accounted for by sup- posing he had chosen a luxuriant specimen. — It is somewhat remarkable that the names of the Chinese, and of the North American Indians, should signify the same thing in their respective languages, viz. a resemblance to the figure of a man. This resemblance, however, it must be con- fessed, even in the branching roots, is rather of a humble kind. The genus Panax was placed by Linnaeus in his class Polygamm, and by late writers in Pen- tandria^ Bigynia, The plants of this f^imily were also referred by Linnaeus to his natural order Ilederacew, or somewhat heterogeneous assem- ' blage of vegetables ; antl by Jussieu to his Araliw. Later botanists have placed them among the Um- 94 PANAX QUINQUEFOLIUM. helUferoiLS vegetables, from which they differ ill their berried fruit. The ^eniis most near to Pa- Dax is unquestionably Aralia, which differs only in the number of styles, a character extremely Aa- liable in the Ginsengs.* .g. Tlie root of the Ginseng has an agreeable taste, consisting of a mixture of sweet and bitter, with some aromatic pungency. Water, both cohl and hot, receives a gummy mucus, which is pre- cipitated by alcohol. The watery extract has the taste and smell of the root in a strong degree. The distilled water gives evidence of a volatile oil, and has the aroma, without the sweetness of the root. The common tests indicate the presence of but little resin, and no tannin. As far as Ginseng has been tried medicinally in this country, and in Europe, its virtues do not appear, by any means, to justify the high estima- tion of it by the Chinese. That it is not a very active substance, is proved by the fact, that a whole root may be eaten without inconvenience. Its place in the materia mcdica is among demul- cents. It approaches more nearly to liquorice, than to any other uiedicine in its taste and exter- * Panax trifoliiim, a beautiful little plant, with nearly the herb of Anemone nemorosa, has always three styles and a tricoccous ber- ry. P. quinquefolium varies from one to three styles, though the usual number is two. GINSENG. ^O iial qualities. Its extract forms a very neat pre- paration, and is by no means unpleasant to the taste. Dr. Fotliergill tells us, that " iu tedious chronic coughs, incident to people in years, a de- coction of it has been of service. It consists of a lubricating mucilage combined with some degree of aromatic warmth.'' Crinseng is principally sold by our druggists as a masticatory, many people having acquired an habitual fondness for chewing it. It is certainly one of the most innocent articles for this purpose. BOTANICAL REFERENCES. Panax quinquefolium, Lin. sp. pi. — Michaux, Florae ii. 256. ■— PuE-SH, i. 191. — WooDviuLE, Med, Bot. i. t, 58. — Botanical Mag. t, 1023. — Aureliana Canadensis, Catesby, Car. Suppl. t. 16.' — Bretnius in Prod, rar, p. 52. — Araliastrum foliis ternis quinquepartitis, Ginseng sen Ninsin officinarum. — Tkew, Ehr. f. 6,/. 1. MEDICAL REFERENCES. BouRDELiJT, Hist, de VJlcad. 1797. — Jartoux, tr. in Phil. Trans. xxviii. 237.— Lafiteau, Memoires concernant la precieuse plante de Ginseng. Paris, 1718. — Sarrasin, Hist. Acad. 1718. — Kaxm, travels, tr. iii. 114. — Osbeck, China, p. 145. — Heberdeiv, Med, Trans, iii. 34. — Fothergill, Gent. Mag. xxiii. 209. — Cuxlen^, Mat. Med. Vol. ii. &c. 9(5 PANAX QUINQUEFOLIUM, PLATE XXIX. Fig. 1. Panax quinquefolium. Fig. 2. A Jiower magnified. Fig. 3. JJmUl in jloxver, the external fruit nearly grown. Fig. 4. Germ, calyx and styles magmfied. Fig. 5. Root. ? 0i) lAJ) FOLYG-ALA SENEGA, Seneca Snake root. PLATE XXX. HE Seneca snake root lias attracted so gen- eral an attention from the medical public, as to have become an article of exportation to Europe, and one which holds a regular place in the drug- gist stores. The plant which produces it has nothing to boast on the score of elegance, and little to attract attention independent of its me- dicinal virtues. It grows in most latitudes of the United States, especially in the mountainous tracts. The specimen, from which our drawing was taken, was .gathered on the borders of Lake Champlain. Tile genus Polygala has a jive leaved calyoc^ two of the leaves wing like, and coloured. Capsule ohcordate, two celled, and two valved. 13 98 POLYGALA SENEGA. The species Senega has erect, smooth, simple stems, with alternate, lanceolate leaves, broadest at base. Flowers slightly crested. Class Biadelphia, order Octandria; natural orders Loment ace as, Jjinn. Fediculares, Juss. The Poljgala senega has a firm, hard, branch- ing perennial root, consisting of a moderately solid wood, and a thick bark. This root sends up a number of annual stems, which are simple, smooth, occasionally tinged with red. The leaves are scattered, nearly or quite sessile, lanceolate, with a subacute point, smooth, paler underneath. Flow- ers white, in a close terminal spike. 1 he calyx, which in this genus is the most conspicuous part cf the flower, consists of five leafets, the two larg- est of which, or wings, are roundish-ovate, white, and slightly veined. Corolla small, closed, having two obtuse lateral segments, and a short crested extremity. Capsules obcordate, invested by the persistent calyx, compressed, two celled, two valved. Seeds two oblong-obovate, acute at one end, slightly hairy, curved, blackish, with a longi- tudinal, bifid, white appendage on the concave side. The spike opens gradually, so that the lower flow- ers ai'ein fruit while the upper ones are in blos- som. SENECA SNAKE ROOT. 99 The rose coloured variety of this plant, as it has heen considered hj Michaux, proves to be a distinct species. Some species wliicli I possess from Carolina have branching, pubescent stems, and very long, loose spikes. Tlie flowers are sev- eral times larger than those of P. senega. The root of the Polygala senega has an un- pleasant and somewhat acid taste. After chewing', it leaves a sensation of acrimony in the mouth, and still more in the fauces, if it has been swal- lowed. These properties it coinmunicates fully to water upon boiling. The process of decoction does not appear to dissipate any of its power, since the distilled water is destitute of the taste and smell of the plant. Alcohol dissolves a substance, apparently of the resinous kind, giving a precipi- tate when water is added. Iron produces little change in solutions of this root, and gelatin oc- casions no alteration whatever. Medicinally administered, the Seneca snake root is sudorific and expectorant in small doses, and emetic and cathartic in large ones. Its most usual mode of exhibition is in decoction, which may be made of suitable strength by boiling an ounce of the root in a pint and an half of water, till it is reduced to a pint. This preparation may 100 POLY GALA SENEGA. in most cases be given in doses of a table spoonful and upward without disturbing the stomach. The first reputation of the Seneca root was one which it divides with a multitude of other plants, that of curing the bite of the Rattlesnake. A re- ward was given by the legislature of Pennsylva- nia to Dr. Tennent for the promulgation of this supposed property. When, however, we consider the number of cases of recovery from the bite of this serpent, under every variety of treatment, we cannot avoid the conclusion, that these injuries are not necessarily dangerous, and that spontane- ous recoveries are perhaps as frequent as those which are promoted by medicine. More certain success attends the use of the Seneca in pneumonia and some diseases related to it. In the advanced stages of pneumonic inflam- mation, after venesection and tlie other usual rem- edies have been carried to their proper extent ; and the cough still remains dry and painful, while the debility of the patient forbids further depletion ; in these cases, I have often found a decoction of the Seneca root to afford very marked relief by promoting expectoration, and relieving the tight- ness and oppression of the chest. Various medl- ey}, writers have spoken favourably of its employ- SENECA SNAKE ROOT. 101 mentin these cases, among whom are Lemery and others, in the Memoirs of the French Academy. It has been found injurious, from its stimulating properties, when given at too early a stage, or during the prevalence of much acute inflamma- tion. Benefit has been derived in asthma from the use of this plant. The following is Dr. Bree's opinion, quoted from his treatise on that disease. " Decoction of seneka is eminently useful in the first species, administered to old people, but in the paroxysm of young persons, I have found it too irritating. This distinction applies to convulsive asthma purely uncomplicated, but the disease is frequently observed in middle aged and elderly persons, to take the character of peripneumonia notha in the winter and spring, and seneka is then the most useful medicine that I have tried. In such cases, it should be united with acetated am- monia, during the febrile state, and as this state gives way, the adtlition of squill, and camphorated tincture of opium, will be found to pi'omote ex- pectoration, perspiration, and urine in a most powerful manner." In croup, this medicine was introduced into notice by Dr. Archer of Maryland. He speaks with much confidence of its utility in that disease, dOS POLYGALA SENEGA. particularly in promoting the separation and dis- charge of the membrane formed in the trachea of patients affected by it. Such a membrane, how- ever, does not exist in all cases of croup. And in the early part of the complaint it may be ques- tioned, how far a medicine, which acts as a stimu- lant to the fauces and neighbouring organs, is en- titled to reliance, in a local inflammation of the trachea. It ought not from such a reliance to exclude more active remedies, especially vcec- section. Dr. Archer's mode of administering it is to give a tea-spoonful of a strong decoction every hour or half hour, according to the urgency of the symptoms, and during the intervals, a few drops occasionally, to keep up a sensible action of the medicine upon the mouth and throat, until it acts as an emetic or cathartic. In various forms of dropsy, the Seneca root has been resorted to with advantage, and has re- ceived the commendations of Percival, Millman, and some others. Its cathartic and diuretic effects are vei-y considerable, when regularly persevered in, in quantities as lai'ge as will set easily on the stomach ; and have in various instances effected the dissipation of dropsical swellings. In chronic rheumatism, this root sometimes does good by its universally stimulant and diapho- SENECA SNAKE ROOT. iOS retic effects. The following case occurred to me some time since in practice. A man labouring under severe rheumatism was ordered to take at intervals a wine glass full of a strong decoction of the Senega made from an ounce of the root in a pint of water. The patient, from a desire to expedite the cure, thought proper to drink the whole quantity at once. The consequence was the most violent vomiting and purging, which lasted the whole night, accompanied with profuse diaphoresis. The patient, as might have been hoped from the violence of the operation, was rad- ically relieved of his disorder. In uterine complaints, particularly amenorrhea, the Polygala senega has been found of decided efficacy. Dr. Chapman of Philadelphia is one of the authorities for its use in these cases. It must be given largely, and continued for some time. The most common mode of exhibition of this root is in decoction, as already mentioned. It is also given in pov/der in doses of twenty or thirty grains. Dr. Tennent likewise employed a wine of Senega made by digesting four ounces of the root in a pound of wine, of which three spoonfuls were given at a dose. 104 POLY GALA SENEGA. \ BOTANICAL REFERENCES. Polygala senega, Liiv. Sp, pL Walter, Car 178. — Wood- viLLE, ii. t. 93. — Bot. Mug. t. 1051. — Michatjx, ii. 53. — Pursh, ii.464.' — 'Polygala caule simplici erecto, &c. Gronovius, Virg. 80. MEDICAL REFERENCES. Tennent, Biseases of Virginia. — Lemery, Duhamei, &c. HisU de VJlcad. 1739, 136. — Archer, Med. Sf Phtjs. Journal, i. 83, 106. — Percival, Med. Journal, iv. 67.— Bree on Asthma, 258« — Massie, Inaug. Diss. Fhilad. 1803. — Thacher, Disjj. 319. — JV*. Evg. Journal, vii. 206. PLATE XXX. Fig. 1. Polygala senega. Fig. 2, Jijlower magnified. Fig. 3. Calyx of the same. Fig. 4. Corolla magnified* Fig. 5. Capsule. Fig. 6. Jlseed, ^^ .^zj:i AMERICAN MEDICAL BOTANY. LIRIODENDROX TULIPIFERA. Tulip Tree, PLATE xxxi. J. HE vegetable world can hardly offer a more interesting object, than a tree of exalted stature and extensive shade, covered with a beautiful and singular foliage, putting forth from its boughs an immense number of large and variegated flowers, at the same time that its trunk affords one of the most useful species of wood, and its bark an aro- matic medicinal agent. Such an one is the Tulip tree of the United States. The forests of the Middle and Western States, according to the representation of Michaux, a- bound with the Liriodendron tulipifera, as do like- wise the elevated parts of Carolina and Georgia. It is found in the Kew England states, but is principally confined to the southern parts of them. 108 LIRIODENDRON TULIPIFERA. Cultivated trees are common in Boston and its vicinity, but I have never met with it in the woods of this part of the country, nor to the north of it upon the sea hoard. In point of size the Liriodendron is exceeded by few trees of the !North American forest. Its growth is regular, straight and majestic. Its trunk often acquires a diameter of from two to three feet, and an elevation of eighty or ninety. In fa- vourable situations it frequently exceeds these di- mensions. Michaux measured a tree near Louis- ville in Kentucky, which at five feet from the ground was twenty two feet and an half in circum- ference, and which he estimated to be a hundred and twenty or a hundred and forty feet in height. Catesby informs us that the circumference is sometimes thirty feet. The names of Tulip tree, White wood, Canoe wood, and Poplar are applied to this tree in diffe- rent parts of the United States. Its flowering tim^ is in the months of May and June. The genus Liriodendron, to which Linnseus has assigned four species of trees, is characterized by a double calyoc, the outer of two, the inner of three leaves ; petals si^, seeds imbricated into a cone. TULIP TREE. 109 The species tulipifera, the only one in Amer- ica, is remarkably distinguished by its lobed and truncated leaves. Together with several other of our finest flow- ering trees and shrubs, the Liriodendron is found in the class Polyandria and order Polygynia, and the natural orders Coadiinatas of Linnseus and Magnolice of Jussieu. The branches of the Tulip tree are of a grey- ish colour inclining to red. The buds which ter- minate them in winter are very curiously con- structed. They are obovate, and flattened or compressed into a sharp edge at the extremity. They are made up of a number of concentric sheaths, each of which contains a single minia- ture leaf between it and the next interior sheath. This leaf, instead of embracing the next sheath, is folded up and bent down upon one side of it. When vegetation begins in the spring the sheaths swell to a large size before bursting, and at length liberate the leaves one at a time, the remains of each sheath becoming converted into a stipule. The leaves of the Tulip tree have a form alto- gether peculiar, and which is not resembled by any other production of our forests. They are divided into four pointed lobes and terminated by a shallow notch, the extremity being nearly 110 URIODENDRON TULIPIFERA. square, and the middle rib ending abruptly, as if eut aff. In the large leaves, the two lower lobes are furnished with a tooth or additional lobe on their outside. They are attached by long pedun- cles and have a beautifully smooth and bright green surface. There is one variety of this tree which has the lobes of its leaves not pointed, but very obtuse. The flowers are large, solitary, and terminal. The outer calyx has two triangular leaves which fall off as the flower expands. The inner calyx consists of three large, oval, concave, veined leaves, of a pale green colour, spreading at first, but afterwards reflexed. Petals six, some- times more, obtuse, concave, veined, of a pale yel- lowish green, marked with an irregular, indented crescent of bright orange on both sides toward the base. Stamens numerous, with long linear anthers opening outwardly, and short filaments. Pistil a large, conical, acute body, its upper half covered with minute, blackish, recurved stigmas ; its lower furrowed, being a mass of coalescing styles and germs. The fruit is a cone of imbri- cated seed vessels, which are woody and solid, their upper portion formed by a long lanceolate scale. Seeds two^ blackish, ovate, one or both oftefx abortive. ^^^^^^'' TULIP TREE. Ill The bark of the Tulip tree has a very bitter taste and a strong aromatic pungency. The lat- ter property appears to reside in a volatile oil. When the bark is distilled with water, it fills the apartment with its fragrant odour, yet the product of the distillation, at least when the process is con- ducted in the small way with the luting of the ap- paratus not perfectly tight, has scarcely any taste or smell. Dr. Kogers informs us that he obtain- ed an oily matter in th« form of a whitish scum on the surface of the water in the receiver. A bitter resin exists in small quantities in the bark. Water dissolves a mucous substance, which is precipitated in a flocculent form by alcohol. Wa- ter is also impregnated with the bitterness, and, if too much heat be not employed, with some of the aroma of the tree. The sulphate of iron pro- duced a dark brown colour, but a solution of isin- glass did not increase the chemical evidence of astringency, producing a barely perceptible effect. Alcohol and proof spirit may be considered the most perfect solvents of the active ingredients of this article, although water dissolves enough to produce its medicinal effect. The bark both of the root and branches acts on the system as a stimulating tonic and diapho- retic, having properties resembling the Cascarilla 113 LIRIODENDRON TULIPIFERA. and other aromatic barks of the shops. The dis- ease ia which it has been most employed is in- termittent fever. But the triumph which results from the occasional cure of this disease is now di- vided among so large a list of tonic medicines, that the distinction conferred by it is not of the most signal kind. As a warm sudorific, this bark seems well adapted to the treatment of chronic rheumatism, and for this purpose it has been employed with success by various medical practitioners in the United States. In some dis- eases of an inflammatory type in which it has been recommended, its stimulating properties render it more like to do harm than good. The only personal acquaintance which I have had with it, is as a stomachic. Administered with this view, it has been acceptable and apparently useful to patients who had derived occasional benefit from " Huxham's tincture," " Stoughton's elixir,'' and similar compositions of bitter and aromatic drugs. The wood of the Tulip tree is smooth and fine grained, very easily wrought and not liable to split. It is used for various kinds of carving and ornamental work, and for articles of house furni- ture. In the Western States where pine lumber is scarce, Michaux tells us, that the joinery or in- side work of houses is most frequently of this TULIP TREE. 113 material. A common use of it tliroughout the United States is in the manufacture of carriages to form the pannels of coach and chaise bodies. For this purpose it is particularly fitted by its smoothness, flexibility and toughness.* The true or heart wood of this tree is of a yel- lowish colour and differs in proportion in different trunks. We are told that two varieties of the tree exist, denominated the yellow and the white, and which appear to be in some measure produc- ed by the mode and place of growth. The yellow variety is most valuable, having least alburnum and being less subject than the other to decay. The Tulip tree has been long since introduc- ed from this country into the forests and fields of Europe. Its use, ornamental appearance, and the facility with v» hicli it is raised, have rendered it one of the most prominent and interesting objects of forest cultivation. * The various economical uses of this tree are treated of at large in the splendid work of the younger Michaux on the Forest trees of JS^orth America. Those who appreciate the value of a cor- rect knowledge of the various internal resources of our country, will be gratified that a translation of this important work, with the origi- nal plates, is now publishing at Paris and Philadelphia. i 14 LIRIODENDRON TULIPIFERA. BOTANICAL REFERENCES. Liriodendron tulipifera, LiivNieus, Sp. pi. — Curtis, Bot. Mag. t, 275. — MiCHAUX, i. 526. — Michaux, rii, Arbresforesti- erSf iii. 202. — Puesh, ii. 382. — Liriodendron foliis angulatis trun- catis, Trew, Ehret, 2. t. 10. Tulipifera virginiana &c« •Catesbt, Car. 1. U 48, — Pxukenet, 1. 117./. 5. &c. MEDICAL REFERENCES. Rush, Trans. FhU. Col. i. 183. — Bart. Coll. 14. — Ciax- TON, Phil. Trans, ahr, viii. 332. — Rogers, Znaitg-Mraidisserfoiiojij 1802. PLATE XXXI. Fig. 1. Jl branch of Liriodendron tulipifera. Fig. 2. Stamens presenting different sides. Fig. 3. FistiU Fig. 4. Fruit. Fig. 5. One of the seeds with its scale or envelope. wBt^.'.-'i: '^^^I'L:\:.. IfeiWi ■0^^ mm M|gpiiqqm %5^ m ^^ @. JUGLANS CIISEREA. Butternut, PLATE XXXII, Of the forest trees which deserve attention for other properties than the uses of their timber, the Butternut is undoubtedly one of the most in- teresting ; its fruit, bark and juices being all con- vertible to use. In favourable situations it becomes a large tree, having frequently a trunk of three feet in diameter. It is abundant in the North- ern and Middle States, as well as in the Western country. Some parts of the District of Maine, I am told, produce woods of considerable extent, consisting wholly of this tree. Michaux tells us, that it is common in the states of Kentucky and Tennessee, that it abounds on the banks of Lake Erie, the Ohio and even the Missouri. The same author states that it is found in the mountainous 116 JUG1.ANS CINEREA. parts of Carolina and Georgia, but that he has not met with it in the lower or level portions of the Southern States. It is variously known by the names o£ Butternut, Oilnut and White Walnut, The genus Jugians or Walnut appertains to thfeLinnae an class Monwcia and order Polyan- drial' Its natural orders are Jimentaceoe of Lin- nsetis and Terebintacem of Jussieu. This genus h^s its harren flowers in aments with a siiJC'parted calyx ; its fertile flowers with a four-cleft superior calyx ; a four-parted corolla i two styles ; anil a coriaceous drupe with a furrow- ed nut ^sr^'^";^'' The species cinerea has its leaflets numerous, ohlong-lanceolate, rounded at hase, downy under^ neath, serrate. Fruit ohlong-o^mte with a termin- al projection, viscid and hairy ; nut oblong, acumi- nate, with a rough, indented and ragged surface. The leaves of the Butternut tree when fully grown are very long, consisting of fifteen or seven- teen leafets, each of which is two or three inches long, rounded at base, acuminate, finely serrate and downy. The flowers appear in May before the leaves are expanded to theu'fuU size. The barren flow- ers hang in large aments from the sides of the last year's shoots, near their extremities. The BtTTERNUT. 117 scales which compose them are ohlong" and deep- ly cleft on each side into about three teeth or segments. The anthers are about eight or ten in number, oblong and nearly sessile. The fertile flowers grow in a short spike at the end of the new shoot. They are sessile and universally pubescent and viscid. When fully grown, they seem to consist of a large oblong germ and a forked feathery style. The top of the germ, however, presents an obscurely four-toothed ca- 1}^.' Within this is a corolla of four nari'ow lan- ceolate petals growing to the sides of the style. The style divides into two large, diverging, feath- ery stigmas nearly as long as the germ. These flowers are somewhat later than the aments in their appearance. The fruit is sessile, several to- gether on the sides and extremity of a long pe- duncle. It is of a green colour, broAvn when ripe, oblong-oval, pointed, hairy and extremely viscid. It contains a nut which is of a dark colour, cari- nated on both sides, sharp pointed, its whole sur- face roughened by deep indentures and sharp prominences. The kernel is more regular than in most nuts of its kind, is very oily, pleasant to the taste when fresh, but acquires a rancid taste bv ao-e. 118 JUGLANS GINEREA. The bark of the branches affords a large quan- tity of soluble matter, chiefly of the extractive kind. In a concentrated tincture I have not been able to detect any appearance of resin. N^o evi- dence of tannin is produced by the test of gelatin. A brownish black colour is caused by the sulphate of iron. The distilled water possesses the taste of the bark in a considerable degree. We are authorized to conclude that water is an adequate solvent for this article, and experience has shewn that the watery extract is one of its best prepar- ations. The sap of the Butternut tree is saccharine, like that of the Maple, and may be procured in large quantities. In the third volume of the Mas- sachusetts Agricultural Repository is an account of an experiment made on this tree by Mr. M. P. Gray. He states that four trees, the trunks of which were only from eight to ten inches in di- ameter, produced in one day nine quarts of sap, from which was made one pound and a quarter of sugar. This quantity, it appears from his state- ment, is equal if not superior to that which the maple affords in the same vicinity. The inner bark of tliis tree, especially that ob- tained from the root, affords one of the most mild and efficacious laxatives which we possess. It is BUTTERNUT. 119 commonly employed in the form of an extract, which preparation is kept in our druggists' shops. Ten or twelve grains of this extract operate gent- ly, and twenty or thirty grains with considerable activity on the bow^els. It has been used for many years in this town by the miost respectable practitioners. The lute Dr. Warren thought highly of its efficacy, and employed it extensively in various complaints, especially in dysentery. During the revolutionary war, when foreign medi- cines were scarce, this extract was resorted to by many of the army surgeons, as a substitute for more expensive imported drugs. In dysentery it seems at one time to have acquired a sort of spe- cific reputation. From numerous trials which I have made with this medicine, it appears to me to possess the qualities of an useful and innocent laxative. When fresli and properly prepared, it is very certain in its effect, and leaves the bowels in a good state. in cases of habitual costiveness it is to be prefer- red to more stimulating cathartics, and many persons whose state of health has rendered them dependent on the use of laxative medicines, have given this the preference after the trial of a vari- ety of other medicines. 120 JUGLANS CINEREA. A patent medicine, long vended in this state under the name of Ciiamberlain's Bilious Cordial, was a tincture of this bark combined with various aromatic seeds. The bark is said to be rubefacient when exter- nally applied, and even capable of exciting a blis- ter. Of this I have had no experience. BOTANICAL REFEREINCES. Juglans cinerea, LiNT?fjEUs, Sp. pi. — jAcquijr, Ic. rar, i. t, 192. — WiLU)Exow, arb. 156. — Wangenheim, »Slmer. 21. t9.f. 21. — MiCHAux, ii. 191. — Pursh, ii. 636. Juglans oblonga Retz. Obs. i. p. 10. — Juglans cathartica, MicHAUX, rn. Arbres foresiiers, i. 165. MEDICAL REFERENCES. Thacher, Dis^, 245. — Bart. Col, 23. 32. — Rush, Med. 06s. i. 112. PLATE XXXIL Fig. 1. Ji. branch of Juglans cinerea in Jlower, the leaves not fully expanded. Fig. 2. J. scale or barren flower from the ament magnified. Fig. 3. J fertile flower magmfed. Fig. 4. The fruit. 3 2 1 ^.y> VERATRUM VIRIDE. American Hellebore. PLATE XXXIIt Xn many parts of the United States the swamps and wet meadows, which have been converted into mowing lands, are peculiarly marked in the early part of spring by two species of plants. These are the Ictodes foetidus already described (PI. xxiv) and Veratrum viride, usually denominated Poke root and Hellebore. Both of these plants spring up more rapidly than the grass around them, and from the largeness and bright green colour of their leaves they are often the most no- ticeable objects in the places of their growth. As the season advances, the Ictodes continues only a tuft of radical leaves, while the Veratrum sends up a straight leafy stalk, which frequently acquires the full height of a man, 16 ISS TERATRUM VIRIDE. This plant is not only found in boggy mead- ows, but by the sides of brooks in rocky and mountainous situations, from Canada to Carolina* Its flowering time is from May to July. •The Vevatrum album or White Hellebore, a well known medicinal plant found in most coun- tries of Europe, has a very close resemblance to the American species. It is, however, a smooth- er plant, and differs somewhat in its flowers, bractes and stalks. .iiroqcnoo m baJiidi'il > "S^^i>$ nThe root of this plant is thick and fleshy. Its ^gupper portion tunicated, its lower half solid and i>scndLng forth a multitude of large whitish radi* cles. The stem is from three to five feet high, roimdisli. solid, striated and pubescent. Through- AMERICAN HELLEBORE. 12^ out the greater part of its length it is closely in- vested with the sheathiilg bases of the leaves. The lower leaves are large, from half a foot to a foot long, oval, acuminate, pubescent, strongly plaited and nerved ; the lower part of their edges meeting round the stem. The upper leaves be- come gradually narrower and the uppermost, which perform the office of bractes, are linear- lanceolate. The flowers are numerous and dis- tributed in compound racemes axillary from the upper leaves, and terminal ; the whole forming a sort of panicle. Peduncles roundish, downy. Bractes boat-shaped, acuminate, downy. The pe- dicel of each flower is many times shorter than its bracte. Calyx none. Corolla divided into six green, oval, acute, nerved segments, of which the alternate ones are longest. All the segments are contracted at base into a sort of claw with a thick- ened or cartilaginous edge. Stamens six with recurved filaments and roundish, two-lobed an- thers. Germs three, cohering, with acute recurv- ed styles as long as the stamens. A part of the flowers are barren and have only the rudiments of styles, so that the plant is strictly polygamous. The seed vessel consists of three capsules united together, separating at top and opening on their inner side. Seeds flat imbricated. 124 VERATRUM VIRIDE. The root of the Veratrum has a bitter taste accompanied with acrimony, and leaves a durable impression on the mouth and fauces when it has been chewed or swallowed. It abounds with a resinous juice, which adheres closely to a knife with which the root has been cut. This resin dissolves abundantly in alcohol. When water is added to the solution, a white turbidness gradu- ally appeal's rendering the liquid opaque, but with- out sediment. The decoction has an intensely bitter taste. It is not rendered turbid by alcohol although some slight flocculi are separated after standing. It is probable that this bitterness re- sides in an extractive principle. The distilled water of the root has a slightly unpleasant taste, without bitterness or pungency. This plant in its medicinal powers resembles the Veratrum album or White hellebore of Eu- rope. It is an acrid emetic and a powerful stim- ulant, followed by sedative effects. As a medicine or as a poisonous plant, it has been known from an early period. The aborigines of the country were fully apprized of its activity. Josselyn in his voyage to New England, which took place not long after the first settlement of the country, in- forms us that the young Indians had a custom of electing their chiefs by a sort of ordeal instituted AMERICAN HELLEBORE, 1^5 with the roots of this plant, which he denominates " white hellebore." A portion of this root was repeatedly given to each individual, and he whose stomach made the most vigorous resistance or soonest recovered from its eifects was considered the stoutest of the party and entitled to command the rest. Kalm tells us that the people of this country, at the time of his travels, employed a decoction of this plant externally in the cure of scorbutic af- fections, and for the destruction of vermin. He further states, that corn before planting was soak- ed in a strong decoction of the Veratrum to protect it against the birds which infest our fields and devour the grain after it is deposited in the ground. When the corn is thus prepared, it is observed, that those birds which swallow it be- come giddy and fall to the ground, an example, the writer informs us, which has the effect to frighten the remainder of the tribe away from the place. Since the celebrity acquired bv the European white hellebore as a remedy for gout, that plant being for a time supposed the basis of the cele- brated Eau medicinale ; the attention of some practitioners has been turned to investigating the properties of the American plant, which so close- 1^6 VERAI^RUM VIRIDE. ly resembles the Veratrum album in its external habitudes. The result of such trials as have been made, establishes beyound a doubt the medicinal similarity of these two vegetables. I have em- ployed the American plant in dispensary practice laldfc■'S'>L»i■:: " " As to its influence as an emetic upon diseased states of the system, there were few opportuni- ties of administering it where any considerable def- rangement existed. In those cases which did oc-. cur it did not appear to be inferior to the common emetics. '' ' '• The degree of operation did not seem to be much increased by the increase of the dose of the medicine. Doses of six grains appeared, when they took effect, to produce vomiting as thorough and complete, as that which followed from larger doses j except that the larger were perhaps more speedy in operating. [ could find no cause for the failure of so many of those cases in which the dose amounted to six or eight grains, except an insensibility in the patient to the stimulus of the medicine ; and this was rendered more probable from the circumstance that generally in those in- stances, the substance failed in producing any ef- fect whatever ; nausea did not often occur when vomiting was not to follow it, and in no instance was it very clear that purging was produced. "Indeed this appeared to be rather a singulaj? circumstance relating to this substance, and one 130 VERATRUM VIRIDE. in which it diflers from most or all other emetics* These articles, when they fail of producing vomit- ing, generally occasion a determination down- wards, and thus produce all the phenomena of ca- thartic medicines. This effect is also frequently produced when they have operated in their pecu- liar way. But in no instance did this appear to he the case with the Hellebore. Some patients, indeed, said that it operated upon them by stool very slightly — but on strict inquiry I did not think that the medicine had had any effect in this way, and that what was told me proceeded from a desire in the persons to attribute some sort of ef- fect to what had been given them. "In the greater number of the cases, the Helle- bore was longer before it produced vomiting than is the case generally with other emetics. It did not often operate in less than three quarters of an hour or an hour — but sometimes the interval was extended to two or three hours — and in one case, although the dose was administered at twelve at noon, its effects were not produced until between nine and ten o'clock in the evening. This tardi- ness in manifesting its effects on the system cor- responds with what has been observed with re- spect to the European species. AMERICiLN HELLEBOPtE. 131 " I made a few experiments with the powder of the Veratrum album in order to compare its pow- ers with those which existed in om* native species. It was given in six cases — of two doses of three grains — neither produced any effect — ane of four was not more effectual — six grains produced some vomiting, but not to any considerable extent — seven no effect whatever — and eight produced in about four hours after taking it considerable effect. If these experiments are to be depended upon, the foreign certainly is not more powerful than the native species. " I endeavoured next to ascertain what degree of power the Hellebore was possessed of over cu- taneous diseases. It has the reputation in the country of some efficacy in these complaints. The ointment and decoction were applied in a number of cases, and it certainly proved to be an applica- tion of considerable power. Its effects in some cases amounted to a removal of the disease en- tirely — and in most, some diminution of it fol- lowed, which was more or less durable. "In one case where there was an eruption about the wrists and other parts of the body, supposed to be the itch — the ointment (made by simmering together a dram of Hellebore in an ounce of lard) after being applied for some time, removed the 13S VERATRUM VIRIIIE, disease. The cure, however, was protracted and tedious. iiii^ A second case was that of a hoy who had on the hack of his head, what appeared to he the com- mencement of Tinea capitis. The ointment made in the same way as that before mentioned, except that simmering was omitted, removed it in the course of a fortnight. It returned again in the course of a few weeks and was again destroyed by the same application. It did not recur so long as I had an opportunity of observing the child, which was, however, not long. "In one clear case of itch, the ointment failed of producing any beneficial effect, and it was ne- cessary to have recourse to the usual remedy. " An instance of a very troublesome and irritat- ing eruption upon the hands and fingers, accom- panied by a venereal taint of the system, was very much relieved by this ointment. Its final remov- al, however, could not be attributed to this, since the patient was under the influence of mercury at the same time. " In some other cases both the ointment and decoction were used with success for a time, but the effects they produced wei;e only partial and temporary.". it :...iU AMERICAN HELLEBORE. 133 Of the power of this plant to relieve the formi- dahle disease of gout, we have the most satisfac- tory evidence. A composition Intended to imi- tate the celebrated Eau medicinale was prepared in England by Mr. Moore from the wine of white hellebore and wine of opium in the proportion of three parts of the former to one of the latter. This compound was used by many arthritic pa- tients both in Europe and America with great success in relieving the paroxysms of the disease. In Boston a considerable number of individuals have been induced to make trial of the remedy, and generally with advantage. But I am inform- ed by several of our most repectable apotheca- ries, that for a long time, especially during the late war, when the white hellebore could not be obtained from Europe, the American plant was used in the preparation of the medicine upon the supposition of its being the same with the European. Various gouty patients made use of it, and no difference was perceived hy them or their physicians in its mode of operation or effect upon the disease. Some were relieved by small doses, which did not even nauseate, such as fifteen or twenty drops, repeated if necessary. Others found a drachm of the mixture necessary, which quantity affected them unpleasantly by vomiting 13.4 VERATRUM YIRIDE. or otherwise. Some experienced such severe ef- fects as to deter them after one trial from a repe- tition of the experiment. In general the parox- ysm of gout was completely suspended hy the op- eration of the medicine. On the whole, we liave sufficient knowledge of the American green hellebore, to feel assured that it is a plant of great activity, closely resem- bling in its properties the Veratrum album of Europe ; and that like that plant it has given re- lief in the paroxysms of gout and in rheumatism. Whether the original Eaii medicinale he a prep- aration of Veratrum, Colchicum, or any other ac- rid narcotic, it is not of consequence here to de- cide. These plants, with several others that might be mentioned, are similar in theii* operation, and probably influence the system when under disease, much in the same way. Some individu- als obtain relief from moderate doses, which do not occasion nausea or any very disagreeable ef- fects. Otliers have not derived benefit except from such quantities as bring on vomiting. Some have experienced very distressing consequences, such as excessive sickness, purging, great pros- tration of strength, impaired vision, and even total insensibility, where the dose has been im- prudently large. AMERICAN HELLEBORE. 135 The wine of green hellebore is prepared like that of the 'vhite, by iniusing for ten days eight ounces of the sliced root, in two pints and an half of Spanish white wine. Before being givenj in gout, it is combined with one fourth part its quantity of wine of opium. Of this compound the dose varies from twenty drops to a drachm. From some observations made by Sir Everard Home respecting the wine of Colchicum autum- nale, it is probable that the wine of Yeratrum may be less violent in its effects, if freed from the sediment which it deposits by standing. Of the substance of the root freshly powdered, from two to six grains will be found a sufficient dose. For medicinal use, however, in most cases it is probable that tlie liquid preparation above described promises more. The external application of the ointment and decoction sometimes produces the same effect on the stomach as the internal use of the plant. In one instance a patient was nauseated and vomit- ing brought on by the ointment applied to an ulcer of the leg. I have known similar conse- quences from a strong decoction in cutaneous af- fections. Might the topical application of this plant be of any service in gout ? 136 YERATRUM VIRli>E. BOTANICAL REFERENCES. Veratrum viiide, Aiton, Kew. iii. 422. — ^Whldenow, S^^ pi. iv. 896. — PuRSH, i. 242. — Rees* Cyclopedia, ad. verb. — ^Ve- ratrum album, MiCHAux, ii. 249.— Helonias viridis, Bot. Mag. 1096. MEDICAL REFERENCES. K.A1M, travds, ii. 91. — Josseitbt, Voyage to Mew Englandi, f. 60. — Thacher, JW Eng. Journal, PLATE XXXII. Fig. 1. Leaf and Jlowers of Veratrum viride. Fig. 2. Petal magnified. Fig. 3, Stamens. Fig. 4. Fistils. Fig. 5. Capsule. Fig. 6. Section of the capsule, showing the seeds. Fig. 7. A seed. yv, . j'.nryi C/e/i/^y?2/€^n' a ^t^a^Vifia^nuj/v^um/ Annin 8c Smitfi, Sc. dog's bane. 149 Class Pentantlria, order Digynia ; natural or- ders Contortce, Linnseus ; Jipocinew, Jussieu. The Apocynum Andros^mifoliura grows often to the height of five or six feet, though its com- mon elevation is three or four. Its stalk is smooth, simple below, branching repeatedly at top, red on the side exposed to the sun. Leaves opposite, smooth on both sides, paler beneath, ovate, acute, on short petioles. The flowers grow in nodding cymes from the ends of the branches and axils of the upper leaves, furnished with mi- nute acute bractes. Calyx five-cleft, acute, much shorter than the corolla. Corolla white tinged with red, monopetalous, campanulate, with five acute, spreading segments. Stamens five, with very short filaments, and connivent, oblong arrow- shaped anthers, cohering with the stigma about their middle. Tlie nectary consists of five ob- long glandular bodies alternating with the sta- mens. Germs two, ovate, concealed by the an- thers. Stigma thick, roundish, agglutinated to the anthers. The fruit is a pair of slender linear- lanceolate follicles, containing numerous imbri- cated seeds each crowned with a long pappus or down, and attached to a slender central recep- tacle. 150 APOCYNUM ANDROS^MIFOLIUai. Every part of the Apocynum when wounded emits copiously a milky juice. When chewed, the root communicates an unpleasant and in- tensely bitter taste. It exhibits, when dry, the following chemical phsenomena.— -If a solution in ether be mixed with alcohol, the alcohol, though not turbid at first, becomes so when the ether evaporates. An aqueous infusion or decoction is of a deep red colour and intensely bitter. A so- lution in alcohol is nearly destitute of colour, but retains the whole bitterness of the plant, and is not disturbed by the addition of water. When submitted to distillation a slight oily film floats on the surface of water in the receiver. — From these facts we may conclude that the Apocynum con- tains, 1. A bitter extractive principle. 3. A col- ouring principle soluble in water and not in al- cohol. 3. Caoutchouc. 4. A volatile oil. In various parts of the Eastern States this plant has been shewn to me by country practi- tioners under the name of Ipecac. This name is applied to it from its power of acting on the stomach in the same manner as the Brazilian emetic. Several physicians, among whom is Dr. RicTiardson of Medway, inform me that they have found about thirty grains of the root to evacuate the contents of the stomach as efiectually as two dog's bane. 151 thirds the quantity of Ipecacuanha. In my own trials it has appeared to me much less powerful than the latter substance, and although it produces vomiting, yet this power is diminished by keeping, and appears to be eventually destroyed by age. When used for the purpose of an emetic, the re- cently powdered root should be employed. The sensible and chemical qualities of this root seem to promise a good effect when given in small doses as a tonic medicine to the stomach. My observations on this subject may hereafter be more mature. (See Appendix.) We have certain- ly very few indigenous vegetables which exceed the Apocynum in bitterness. Perhaps its emetic property when given in large doses may be owing to this quality. Most bitter vegetables produce vomiting when administered in large quantities. Kalm observes in his travels in North Ameri- ca, that in some parts of the country tliis plant was suspected of poisonous properties like those of the Rhus vernix. The country people inform- ed him that the milky juice rubbed on the hands produced blistering in many persons, and that some were affected in the same way even by the effluvium of the plant. — -I know of no other au- thority than that stated above for the existence of .such a property in the Apocynum. The plant is 15S APOCYNUM ANDROSiEMIFOLIUM. common and well known in Massachusetts, Yet I have never heard it suspected of deleterious properties. The flowers of the Apocynum have a power of catching flies and small insects which was as- cribed by Dr. Darwin to an irritability in the in- ternal organs. Mr. Curtis in the Botanical mag- azine, has considered this subject at large, and ascribes the property to a more rational cause. In consequence of the close convergency of the anthers and their adhesion to the stigma, a nar- row fissure or slit exists, which becomes more contracted near the top. The insect in search of the honey at the bottom of the flower, inserts his proboscis between the stamens into the cavity within them. In extricating it from this situa- tion the proboscis is sometimes caught in the fis- sure, and in proportion to the efforts made by the insect to 'escape it becomes more closely wedged in the upper part of the slit, so that its deliverance by its own powers becomes at length impractica- ble. Musquitoes, gnats, and small flies are fre- quently found dead in this confinement. DOG'S BANE. 153 BOTANICAL REFERENCES. Apocynum androssemifolium, Lin. Sp, pi. — Curtis, Botani- cal Magazine, t. 280. — Darwiiv, Botanic Garden^ ii. 182. — Mx- €HAUX, Flora, i. 121. — PmisH, i. 179i MEDICAL REFERENCE. Kalm, Travels, iii. 26. PLATE XXXVI. T'ig. 1. Branch of Jlpocijnum androscamifolium. Fig. 2. Fair of follicles. Fig. 3. Cone formed of the united stamens. Fig. 4. Stamen detached. Fig. 5. /Si(fe view of the calyx, nectaries and germs. Fig. 6. Fronf Tiew of the same. Fig. 7. ,i seed. DIRCA PALUSTRIS. Leather Wood, FLdTE xxxrn. X HE diversity of climate in different latitudes of the United States does not prevent this shrub from appearing in the most rigorously cold as well as in the warmest sections of the country. I have seen it growing plentifully on the hanks of the Kennebec, in Maine, and Mr. Bartrani found it in great vigour on the Savannah river in Georgia. It is a marshy shrub frequenting low woods and the vicinity of water, flowering in April and May. It is commonly of humble growth, though Mr. Bartram found specimens six or seven feet in height. It is remarkable for the flexibility of its wood and toughness of its bark, which are so great that it cannot be broken with- out great difficulty. The Aborigines employed LEATHER WOOD. 153 it for their cordage, and from its great tenacity the name of Leather wood lias been applied to it in most parts of the United States. The Canadian French called it Bois de Plomb or Leaden wood from its flexibility. The generic character of Dirca consists in k tubular corolla without calyx^ having its border obsoletely toothed. Stamens longer than the corol- la. Berry one-seeded. The genus contains but a single species. Class Octandria^ order Monogynia, Natural orders Vepreculce, Lin. Thymelww, Juss. The Dirca is an irregular shrub somewhat distinguished by the horizontal tendency of its branches and leaves. The branches have an in- terrupted or jointed mode of growth. The leaves are scattered or alternate, with very short petioles. They are oval, entire, subacute, downy, when young, smooth and membranous when fully grown, and pale on the under side. The flowers appear long before the leaves. Previously to their emerging they exist in miniature within a small hau^y bud, which occupies a sheath or cavity in the end of each flowering branch. They are commonly in bunches of three together with their peduncles cohering. Each flower is about half an inch long, of a yellow colour and without ca- 156 DIRCA PALUSTRIS, lyx. The corolla is funnel-shaped, with a con« traction near the base and another in the middle, its border dilated, and slightly and irregularly toothed. Stamens eight, much longer than the corolla, the alternate ones longest, the filaments capillary and inserted into the tube ; the anthers roundish. Germ ovate placed obliquely, the style appearing to issue from one side. The style is capillary, curved, and longer than the stamens. The fruit is a small oval, acute, red, one-seeded berry. Chemically examined, the bark of this shrub discovers a slightly resinous character by the pearliness which its tincture assumes on admix- ture with water. The decoction is somewhat mucilaginous and deposits slight flocculi on the addition of alcohol. Iron and gelatin produce no evidence of tannin or gallic acid. The distilled water has an unpleasant odour, but is void of ac- rimony. * The bark of the Dirca has a peculiar and rather unpleasant taste. When swallowed, it leaves a sensation of acrimony in the fauces which continues for some time. If taken in the quantity of six or eight grains, it produces a sense of heat in the stomach and at length brings on LEATHER WOOD. 107 vomiting. This effect pretty certainly occurs if the bark be recent or freshly powdered. A variety of observations on this shrub have been made by my pupil, Dr. John Locke, who first called my attention to the examination of its properties. He found on experiment that not only the distilled water, but the decoction also was void of acrimony, and that in the boiled bark this property was very much diminished, though still present. The watery extract had consider- able bitterness, but scarcely any of the peculiar acrimony of the plant. Taken in doses of a drachm, it did not produce any very sensible ef- fect. Alcohol without heat acquired but slight sensible properties from the bark. ^N'othiug came over by distillation with alcohol, but the alcohol remaining in the retort had acquired the acrimony. The spirituous extract procured by evaporating this decoction was equal to one twen- ty fourth of the bark from which it was obtained. It contained the acrimony in a concentrated form, producing a more powerful effect on the fauces than the fresh bark. It was largely but not com- pletely soluble in water. » Dr. Locke gave the freshly dried root to various patients in doses of from five to ten grains, which quantity in most instances proved powerfully 158 DIRCA PALUSTRIS. emetic, and sometimes cathartic. It was found to be deteriorated by keeping, and did not pro- duce the same effects when very old. In conse- quence of some statements which have been made in regard to its vesicating properties, Dr. Locke applied portions of the bark moistened with vinegar to the skin of his arm. In twelve hours no effect was produced, in twenty four some red- ness and itching took place and in thirty a com- plete vesication followed. The fruit of the Dirca has been suspected of narcotic properties. Dr. Perkins, of Hanover, N. H. has communicated the case of a child which had eaten these berries with effects like those produced by Stramonium, such as stupor, insensibility, and dilatation of the pupils. An emetic brought up the berries and the child grad- ually recovered. A medical student who took several of the berries found that they produced nausea and giddiness. The medicinal action of the bark of the Dirca probably depends on its acrid constituents, which appear to be partly of a resinous and partly of a volatile nature. Its properties appear somewhat allied to those of Polygala senega, for which it might perhaps be substituted in small quanti- ties. It is best given in substance, though on ac- LEATHER WOOD. 159 count of the tenacity of its fibres it is difficult of subdivision. After beating in a mortar it resem- bles fine lint more than powder. Its vesicating properties appear too feeble to promise much utility. I have introduced the Dirca in this place, not so much because it has been yet applied to any medical purpose of great importance ; but be- cause it would be improper, in a work like the present, to pass over unnoticed a shrub of such decided activity. BOTANICAL REFERENCES. Dirca palustris, List. Ammnitates academiccEf iii, 1. 1. 6. 7. = DuHAMEL, w3r&. vi. t. 212. — PuRSHji. 236. — Michaux, i. 268. Baetram, Travels, 309. — Kaxm, Travels, ii. 148. MEDICAL REFERENCE. B. S. Barton, Coll, 32. PLATE XXXVII. Fig. 1. A branch with leaves of Dirca palusiris. Fig. 2. A branch injlower. Fig. 3. Fruit, Fig. 4. Germ and shjle much magnijied. Fig. 5. Magnified corolla, laid open. Fig. 6, Flower magnified. UUBUS VILLOSUS. Tall Blttckberry, PLATE XXXVIU. J. HE family of shrubs comprized under the term Rubus, including the various species of Baspherry, Blackberry, Beivberry, ^c. is exten- sively diffused througliout the United States. Many of them are known as troublesome bram- bles, a few are unarmed, and a certain number are nearly herbaceous. Some are distinguished by the elegance of their flowers, and others by the deliciousness of their fruit. The Rubus vil- losus is one of the most common and interesting species. It abounds among the brushwood of neglected fields and pastures, about fences and the borders of woods, from the Eastern to the Southern states. Being of rapid growth, it is frequently troublesome to the farmer by spread- JlTz^-tn. & Smr^t- Sc TAIiL BLACKBERRY. I6i ing in his lands, although it offers some amends for the intrusion by the abundance and fine flavour of its fruit. It is commonly called tall or high blackberry in distinction from the B. trivia- lis or low blackberry, which it greatly resembles in the quality of its fruit. It is in flower in June and its fruit is ripe in August and September. For the generic character, it has a Jive-cleft calyx ; five petals ; ami a compound herry com- posed of one-seeded acini* — This species is puhes- cent, bristly and prickly, the leaves in threes or fives, leafets ovate, acuminate, serrate, pubescent, with the petioles prickly ; fiowers racemed. Class Icosandria, order Polygynia ; natural or- orders Senticosoe, Lin. Rosaceoe, Juss. This shrub has a tall, branching, prickly stem, which is more or less furrowed and angu- lar. Leaves mostly in threes on a channelled, hairy petiole. A few are solitary and some qui- nate. Leafets ovate, acuminate, sharply and une- qually serrate, covered with scattered hairs above, and with a thick soft pubescence underneath. The terminal leafet is pedicelled, the two side ones sessile. The petiole and back of the mid- dle rib are commonly armed with short recurved prickles. The flowers grow in erect racemes with a hairy, prickly stalk. The pedicels are SI •0 163 RUB us VILLOSUS. slender, an inch or two in length, covered with glandular hairs and supported bj lanceolate hractes. Calyx divided into five ovate, concave, hairy segments ending in an acuminate point or a lanceolate leafet. Petals five, white, ovate or oblong, concave, contracted into a short claw at hase. Stamens very numerous, with roundish anthers and slender, white filaments. Germs nu- merous, covering a conic central receptacle. Styles capillary, arising from the sides of the germs, persistent. Fruit a black, shining, com- pound berry formed of pulpy acini attached to the receptacle, each containing a single oblong seed. The bark of the root of this bramble is the part which has been medicinally employed. It is a pure and strong astringent, which property it manifests both by its sensible elTects and by chemical examination. When treated with the sulphate of iron both the tincture and decoction assume a beautiful dark purple colour and throw down a copious precipitate. A precipitate also takes place on the addition of gelatin, which is copious, white and opaque. The alcoholic solu- tion is in part decomposed by water. The sub- stance precipitated does not occasion the uniform turbidness which usually attends the separation TALL BLACKBERRY. 163 ©f resins, but exhibits a floctulent appearance like that of congulated mucilage. These flocculi, however, when collected and dried, exhibit the common resinous properties on exposure to heato I subjected the dried bark to distillation, but the distilled water was nearly insipid, possessing only a very slight flavour of the root. 1 he properties of this bark ai'e those of a very powerful astringent. I have tried its operation . sufficiently to become satisfied of its efficacy both internally and externally used in a variety of cases which admit of relief from medicines of its class. It is true that our list of vegetable astringents has become very numerous and the cases which re- quire them are perhaps less frequent than vfas formerly imagined ; yet as we continue to im- port and consume various foreign medicines of this kind, we ought not to exclude from attention native articles of equal efficacy. Professor Chap- man, of Philadelphia, expresses a very decided opinion in regard to the powers of this substance. " Of the vegetable astringents," says he, ''this I have reason to believe is among the most active and decidedly efficacious in certain cases. To the declining stages of dysentery after the symp- toms of active inflammation are removed, it i^ well suited, though I have given it. T think, with 164 IIUBUS VILLOSUS, greater advatitage under nearly similar circum- stances, in cholera infantum. To check the in- ordinate evacuations which commonly attend the protracted cases of this disease, no remedy has ever done so much in my hands. Even two or three doses will sometimes so bind the bowels that purgatives became necessary. Being so powerfully astringent, this medicine is useful in all excessive purgings, and especially in the di- arrhea of very old people, as well as when it oc- curs at the close of diseases. During my atten- dance in our public institutions I had abundant opportunities of testing its efficacy in these cases." The fruit of the blackberry is among the most delicious productions of the uncultivated forest. To an agreeable combination of sweetness and acid it adds an aromatic fragrance which is surpassed by few of the lighter fruits produced among us. It differs in size and perfection in different seasons, warm and dry summers being most favourable to its perfect maturity. Our markets, however, are rarely destitute of this fine fruit in the months of August and September. Some other species of Rubus are closely allied to this in the qualities of their fruit and bark, particularly the Miibus procumbens, commonly called low or running blackberry or dewberry. TALL BLACKBERRY. 165 The fruit of this species is usually larger but produced in smaller quantity from the inflores- cence b^ing nearly solitary. The bark is not less astringent than in the present species. BOTANICAL REFERENCES. Rubus villosus, Aiton, Kew, ii. 210. — ^Wiildenow, ii. 1085. -MiCHATJX, i. £97. — PuESH, i. 346. MEDICAL REFERENCES. Chapmaw, Therapeutics and Mat, Med, ii. 474.^.Thacheii, nisp. 341. PLATE XXXVIII. Fig. 1. Jl specimen of Rubus viUosus in Aower. Fig. 2. Stamen. Fig. 3. Pistils, Fig. 4. The ripe fruit. CASSIA MARILAISBICA. Jiniericmi Senna, FLJiTE XXXIX, A HIS tall and luxuriant plant is found in rich soils ill the vicinity of water from New England to Carolina, and westward to the banks of the Missouri. The most northern situation in which I have known it decidedly indigenous, is on tlie banks of the Quinebaug river near the southern boundary of Massachusetts. It is, liowever, cul- tivated in gardens for medicinal use much further to the north. It is a vigorous herbaceous peren- nial with stalks four or five feet high, having their summits covered in July and August with brilliant yellow flowers. The extensive genus Cassia has a five-leaved calyoc and five petals ; anthers unequal, the three uppermost harren, the three lowermost longer, AMERICAN SENNA. ' 167 curved and beahed. Legume two-valved.^—The species Marilandica has eight or nine pairs of leaf- ets, which are oblong-lanceolate, and mucronate ; an obovate gland on the petiole. Bacemes axillary and terminal ; legumes linear and curved. Class Becandria, order Monogynia. Natural orders Lomeniaceae, Linn. Leguminosw, Juss. The stems, which grow in bunches and often attain the height of five or six feet, are round, striated, and invested with a few scattered hairs. Petioles compressed, channelled above, bearing from eight to ten pairs of leafets, which are ob- long, smooth, somewhat hairj at the edges, pale on the under side, supported by short crooked pedicels, and mucronated with a rigid bristle at the end. On the base of the petiole is a large ovate pedicelled gland, of a shining green, ter= minating in a dark point at top, which is some- times double. Each petiole is also furnished with a pair of linear-subulate, ciliate, deciduous stip- ules. The flowers grow in axillary racemes, ex- tending quite to the top of the stem. The pe- duncles are slightly furrowed, pedicels supported by bractes like the stipules, and marked with mi- nute, blackish, glandular hairs. Leaves of the calyx yellow oval, obtuse, the lateral ones longest. Petals five, bright yellow, spatulate, concave, veiy 168 CASSIA MARILANDICA. obtuse, three ascending and two descending^ Stamens ten with yellow filaments and brown anthers. The three upper have short abortive anthers. To these succeed two pairs of deflexed linear anthers. The remaining three, or lower- most, are much longer, crooked, and taper into a sort of beak, the middle one being shortest. The anthers open by a terminal pore. Germ descend- ing with the lower stamens, hairy ; style ascend- ing, stigma hairy, moist. The fruit consists of long legumes which are pendulous linear, curved, swelling at the seeds, and ftirnished with slight hairs. The predominant constituents of the leaves in this plant appear to be resin extractive, and a volatile matter. The tincture is of a dark brown colour and is rendered extremely turbid by water. The infusion and decoction have a lighter colour and the peculiar taste of the plant. The dis- tilled water is nauseous. It is found that both the infusion and decoction answer for medicinal use, yet it is probable that the tincture would be more strongly operative, did not the sedative ef- fects of the alcohol prove a balance for the addi- tional parts of the medicine dissolved. The Cassia Marilandica is related to the ori- ental Senna in its botanical habit, and nearly re- AMERICAN SENNA. 169 senibles it in its medicinal virtues.* Neither of tbese plants is to be ranked among the most ac- tive cathartics, and they require to be taken in much larger quantities than aloes, rhubarb or * There is no, doubt that the true Alexandrian Senna is the product of the Cassia Senna of Linnseus and of Willdenow. La- marck has occasioned an unnecessary confusion on this subject, and misled other botanists, bj changing the Linnasan name C. senna to C. lanceolata ; while he has appropriated the name C. senna to the variety /3 of Linnseus, which is the Italian senna, since very properly named C. Ifalica. See Rees' Cyclopedia, Art. Cassia, &c. The African plant is accounted the most active, although the Italian Sen- na cultivated in Jamaica, according to Dr. Wright, proved fully- equal to it in efficacy. The greater part of the Senna consumed in the United States is imported from the East Indies. Smaller quantities occasionally reach us from different ports of the Mediterranean and Red seas. The common India senna has a lanceolate leaf narrow and acute; pe- tioles Vv'ithout glands, bearing from five to nine pairs of leaves; and a flat oblong curved legume. Medicinally considered, it is one of the most valuable sorts, operating with mildness and certainty. The facility and cheapness with which it is obtained in India, has long caused it to predominate in our markets. The India senna, which I have examined, has been very pure, consisting only of leaves of Cassia. The Egyptian has frequently a slight admixture of foreign leaves which are nauseous and bitter. The Cassia senna would doubtless succeed in our Southern states. The product, consisting of the whole leaves of the plant, must necessarily be large, and would well reward the attention of planters. Ripe seeds may probably be found among the senna of the shops which will vegetate, if not too old. According to Roxburgh and Carey, the Arabian senna cultivated at the Bengal garden is a biennial plant. 22 170 CASSIA MARILANDICA. jalap, to produce their desired effect. Hence the common form of administering senna is in in- fusion, a large portion being made to communi- cate its strength to water at a time. As far as I have been able to observe, about one third more of the Cassia mai^ilandica is required to produce a given effect, than of the C. senna. This objec- tion will prevent it from superseding the senna of the shops, although the facility, with which it may be raised in any part of the United States, will render it a convenient medicine where cheap- ness is an object. It is already cultivated in gardens for medicinal use, and the infusion and decoction are considerably employed by families and country practitioners. BOTANICAL REFERENCES. Cassia Marilandica, Liif. Sp. pi. — Marttn, Cent. t. 23. — MiCHATJX, Flora, i. 261. — Puhsh, i. 306. — Nuttajll, i. 280. — Cassia mimosse foliis, &c. — Duxenius, t. 260,/. 339. MEDICAL REFERENCES. B. S. BARToif, Coll. 32. — Thachee, Bisp. 178, — Chap- man-, Therapentics. PLATE XXXIX. Fig. 1. Cassia Marilandica. Fig. 2. The three upper stamens. Fig. 3. The fourth andjifth ditto. Fig. 4. The sixth and seventh ditto. Fig. 5. The three lowest ditto. Fig. 6. *3 legume. ' J'l.XL ^ceoi!^^^-n.f EOOKSTOB.E, NO. 1 COE.NHILL. TT5rir.PRESS....HII.XIAED AJTD MZTCALF* 1820. PREFACE TO THE THIRD VOLUME. A HE subjects of the present work, for reasons which prevail in many publications of the kind, have been inserted without reference to any par- ticular arrangement or system. Those plants received the earliest place, the observations re- specting which were earliest matured, and the drawings of which were first completed. Al- though this plan has been objected to in some foreign criticisms, it is the one pursued in several of the most extensive and useful botanical works of the day, which are accompanied with plates ; and in periodical publications, or those wbich appear in successive numbers, it has more than one decided advantage. It gives time for all the figures to be completed at leisure, from perfect specimens, in proper and convenient seasons ; at the same time that it does not necessitate prema- ture and imperfect descriptions of their subjects, which must take place were an arrangement adopt- VI PREFACE. ed, which might require the first insertion for plants not yet obtained or imperfectly examined, A systematic method may be adhered to in a work which is furnished for the press at once, but must occasion delay and imperfection in a periodical one. As the American Medical Botany is terminat- ed by the completion of its third volume, the opportunity is now afforded for taking a methodi- cal view of its contents. Considered in a medici- nal point of view, the subjects will be best classed as in systems of Materia Medica, by a reference to their leading properties or most striking modes of operating on the human system. In this light they may be arranged as follows. JVarcotics. Tonics. Datura Stramonium, Menjanthes trifoliata.. Conium maculatum. Hamulus Lupulus, Cicuta maculata, Eupatorium perfoliatum^ Hjoscjamus iiiger, Coptis trifolia, Nicotiana tabacum, Cornus fiorida, Solanum dulcamara, Gentiana Catesbsei, Kalmia latifolia r Aletris farinosa, Pol jgala rubella, Astringents. Sabbatia angularis. Geranium maculatum, Piiuos verticillatus, Statice Caroliniana, Liriodendron tulipifera. Arbutus Uva ursi. Magnolia glauca. Rubus villosus, AcHd stimulants. Rhododendron maximum, Arum triphyllum, Nympheea odorata, Ictodes fcetidus, IMvrica cerifera. Ranunculus bulbosus. PREFACE. Vll Emetics. Lobelia inflata, Phytolacca decandra, Gillenia trifollata, Veratrum viride, Sanguinaria Canadensis, Iris versicolor, Apocynum androssemifolium, Dirca palustris. Euphorbia ipecacuanha, Euphorbia corollata. Erythronium Americanuni. Solidago odora, Gaultheria procumbens, Laurus sassafras, Illicium Floridanum. Diuretics. Juniperus communis, Pyrola Umbellata. Expectorants. Polygala senega, Asclepias tuberosa. Cathartics. Podophyllum peltatum, Juglans cinerea, Triosteum perfoliatum, Cassia marilandica. Demulcents. Panax quinqefolium- Anthelmintics. Spigelia marilandica. Diaphoretics. Aristolochia serpentaria, Asarum Canadense, Xanthoxylum fraxineum. External stimulants. Juniperus Yirginiana, Rhus Vernix, Rhus radicans. We avail ourselves of classification in the Materia Medica founded on the kind of operation which medicines exert on the human hody, be- cause there are seemingly no better characteris- tics by which to arrange them. But even this method is defective, because few medicines are simple in their operation, and of course most of them have claims to stand in more tlian one class. As examples, Tobacco, Henbane, Fox- Vill PREFACE. glove, and Opium are all of them properly placed by authors under the head of Narcotics. But of these, Tobacco is an emetic, Henbane a cathartic, Foxglove a diuretic, and Opium, while it checks all other excretions, is itself sudorific. Mercury, under its different forms and modes of adminis- tration, is capable of fulfilling hrJi' a dozen differ- ent intentions. The classifier of medicines then can do no more than to arrange them by their most obvious and well known properties, whatever these may be, leaving it understood that the name of a class is by no means fully descriptive of the character of its contents,* In forming a selection of sixty plants to be represented in this work, it has been endeavoured to choose those which are among the most interesting to botanists, at the same time that they possess claims upon the attention of medi- cal men. It is by no means to be asserted that all these possess so decided an efficacy as to enti- tle them to the rank of standard medicines, or to make it advisable that pharmacopceias should be swelled by their introduction. A part of them no doubt are eminently entitled to this distinction. Others are efficacious only in a second degree, * For a botanical arrangement of the plants, see the systematic index at the end of the volume. PREFACE. IX but are still in use, and often advantageously so, in the hands of country practitioners. Tisere jare some of yet inferior efficacy, which, having formerly enjoyed a, certain degree of medicinul notoriety, are inserted here with a view of defin- ing their true character. The progress of botanical students is mucli facilitated by the possession of correct drawings and dissections of a variety of dissimilar plants. In this country botanical figures, especially of American plants, are scarce, and accessible to but a small number of those who pursue this study. It is hoped that the present work may, in a cer- tain degree, supply the deficiency, at least until the extension of natural science among us, and the increased number of botanical students, shall call forth and support works of greater magnitude. A part of the plants contained in this work have never been figured in any botanical work. Others have been represented a great number of times ; yet their importance, in a medical point of view, required their admission ; and the figure being always made from an American specimen, it may, on this account, be not destitute of in- terest. Having arrived at the termination of the American Medical Botany, the author feels it 9, X PREFACE. incumbent on him to state, that he has at no time, had cause to regret the undertaking of a work, which has furnished a most interesting employ- ment for his leisure hours ; and which has been honored with a patronage, greatly exceeding his anticipations. AMERICAN MEDICAL BOTANY, GILLENIA TRIFOLIATA. Common Gillenia, PLATE XLI. iN OTWITHSTANDING tlie principle avowed bj Linnseus, that genera are formed by nature ; the determination of generic consanguinity in species occasions in many instances one of the greatest perplexities of the botanist. What difference in structure and cisternal form either of flower or fruit, is sufficient to separate families of plants from each other ; is a point often difficult to decide , and is perhaps as frequently set at rest by conve- nience and by arbitrary decision, as it is by any unexceptionable boundaries designated in nature. When the species of a vegetable order are exceed- ingly numerous, and a close similarity pervades the whole ; genera are multiplied by botanists, that the discrimination of species may be iVtciiitat- 13 GILL.ENIA TRIFOLIATA, ed. Oil the otlier hand, where a group of species is not unwieldy from its size, or deficient in dis- tinctive marks, the genera are made as compre- hensive, as natural afiinity will permit. The di- versity of structure, which exists in the flowers of Gentiana^ or the fruit of Bimias, would he deemed ample f jundation for constructing half a dozen ge- nera among the umhelliferous, leguminous, or gramineous orders. But as the species of the genera above have a strong agreement in one part of their fructification, as well as in general habit, and as no great obscurity or inconvenience results from keeping them together, it has not been thought worth while to multiply nomenclature by arranging them under separate titles. The separation of Gillenia from Spiraea is one of those cases, upon which the botanist may hesi- tate long, without finding reasons strong enough to influence his decision. The natural order to which they belong is remarkable for having its genera well defined, so that there is no necessity for the separation, arising from confusion or indis- tinctness. The fruit of Gillenia is exactly the fruit of Spiraea, and the habit of the herb in one is not very foreign from that of the other. There is nevertheless something in the irregular corolla, taken in conjunction witli the campanulate calyx, COMMON GILLENIA. 13 which I think would prevent any one, at first sight, from considering the plant a Spirsea ; and which may afford sufficient ground for following the example of Moench in considering it a distinct genus. The Crillenia trifoliata grows in woods, in a light soil, from Canada to Florida. In the mari- time states I have not met with it north of the Hudson. Its flowering time is in June and July. The generic character, which distinguishes this plant frOm Spirsea, is as follows : Calyac cam- paniilcde, fixJe toothed ; corolla irregular^ petals lanceolate^ contracted near the claws ; capsules five, The species trifoliata has ternate, hmceolate, serrate leaves, and stipules tvhich are minute, linea- lanceolate and nearly entire. Class Icosandria, order Pentagynia. Natural orders Seniicosce, Lin. Mosacew, Juss. This plant has commonly a number of stems from the same root, which are a foot or two in height, erect, slender, flexuous, smooth, commonly of a reddish tinge, and considerably branched. The leaves are alternate, trifoliate, with very short petioles, furnished with small lanceolate, slightly toothed stipules at the base. Leafets ovate, lan- ceolate, acuminate, sharply toothed, the upper ones often single. The flowers are few in nurn- 14 GILLENIA TRIFOLIATA. ber, scattered, terminal, nodding, formin^^ a sort of panicle, with long peduncles, occasionally fur* nished with minute lanceolate bractes. Calyx subcampanulate, or tubular, with the lower half narrowest, the border divided into five reflexed acute teeth. Petals five, the two upper ones separated from the three lower, white, with a red- dish tinge on the edge of the outside, lanceolate, unguiculate, contracted, and approximated at base. Stamens about twenty in a double series within the calyx. Germ round, styles approximated. Capsules five, not one^ as some authors have stated, diverging, oblong, acuminate, gibbous without, sharp edged witbin, two valved, one celled, one or two seeded ; seeds oblong, corresponding in shape to the capsule. The root of this plant is much branched and knotty. It consists of a woody portion, invested with a thick bark, which when dry is brittle, and Tery bitter to the taste. The predominant, solu- ble ingredients in tiiis root appear to be a bitter extractive matter, and resin. When boiled in water, it imparts to it a beautiful, deep red, wine colour, and an intensely bitter taste. This decoc- tion undergoes no cliange from alcohol or gela- tine, though it gives a precipitate with muriate of tin. Water distilled from the I'oot has its peculiar COMMON GILLENIA. 15 flavour, with little of the bitterness. A large portion of resin is precipitated on the addition of water to an alcoholic tincture of the root. Under the name of Spirsea trifoliata, this plant is well known to students of the American Materia Medica, as an emetic. To the remarks which have been made by various writers, I can add my own testimony of its possessing properties in a certain degree analogous to those of ipecacuanha. It requires, however, a larger dose, and I have not been satisfied that it is at all certain in its opera- tion. At times I have known fifteen grains to produce a full operation ; at others thirty grains have been given to a person already predisposed to vomit, without producing the least sensible effect. The best printed account which I liave found respecting its mode of operation is contained in an Inaugural Dissertation, published at Phila- delphia in 1810, by Dr. De la Motta, then of Charleston, S. C This gentleman, in addition to other trials, took tlie root himself twice in sufficient quantity to produce vomiting. '' In order," he says, " to ascertain this particular power of the Spirsea, I, early in the morning, fasting, prescribed for myself twenty -five grains of the powdered root of this plant. 1 divided this quantity into four 46 OILLENIATRIFOLIATA. equal parts, one of which I took every fifteen minutes, conceiving this a sufficient length of time to allow for the action of each dose in my stomacli. The first dose taken produced no manifest effect. At the expiration of fifteen minutes I took a second dose ; — a degree of un- easiness was experienced, attended with some nausea ; — at the end of fifteen minutes more I swallowed a third dose, — nausea increased, until the convulsive action of my stomach took place. The fourth dose was now taken ; considerable effi)rts were made to vomit, and finally the con- tents of my stomach were thrown up, together with a profuse quantity of bile. The determina- tion of blood to my head, the frequency of my pulse, and heat of my system were much aug- mented. I now drank half a pint of warm water ; the action of my stomach subsided, and the nau- sea gradually wore off. A portion of the medicine, I was induced to believe, had insinuated itself into the intestines, as two copious evacuations were produced within the space of three hours. During the day I felt much debilitated, but im- puted this to the general effect of emetics. " I was thus satisfied with respect to its efficacy as an emetic upon an empty stomach. But, being still desirous of becoming better acquainted with COMMON GILLENIA. 17 its particular operation after eating an usual meal, I made a second experiment, one month after the first. In the morning, one hour after I had eaten a hearty breakfast, I took twenty grains of the medicine, in divided doses, as in the former ex- periment. At the expiration of a very few min- utes nausea commenced, which continuing to increase, with very few efforts I discharged the contents of my stomach. The effects of the second trial answered exactly my expectations." Some authors have attributed a tonic power to the Gillenia, when administered in s*mall doses. That it possesses such a power is rendered prob- ble by its bitter taste, and by the fact, that small doses of ipecacuanha exert a beneficial stimulus on the stomach in certain cases of debility in that organ. IS GILLENIA TRIPOLI AT A. BOTANICAL REFERENCES. Gillenia trifoliata, Mcench, Metli. suppl. p. 286. — Nuttall, Genera, i. 307. — Spirgea trifoliata, Lin. — Willd. Sp. pi. ii. 1063.— Curtis, Bot. Mag. t. 489. — Miller, Icones, 256. — Michaux, Flor, i. 294.— PuRSH, i. 243. MEDICAL REFERENCES. ScHOEPF, 80. — B. S. Barton, Coll. 26. — De la Motta, Inaugural Bissertation. , PLATE XLL Fig. 1. Gillenia trifoliata. Fig. 2. Calyx. Fig. 3. *i petal. Fig. 4. Flower opened, shelving the situation of the stamens. Fig. 5. Germ and styles. Fig. 6. Styles separated. P/.. .\7.// 3 ^ '. /l/f^.) rarnrrr/dti % Annirr I- Sr;ifJ> RHUS EADICANS. Poison Ivy. PLdTE XLIL JuiKE the Rhus vernix, describetl in our first volume, this plant is regarded with aversion, and too frequently furnishes cause to be remembered by persons of susceptible constitution, who un- warily become exposed to its poisonous influence. The general recognition of its deleterious charac- ter is evinced in the application of the names Foison vine, Poison creeper, and Poison Ivy, which are given to it in all parts of the United States. The Rhus radicans is a pretty common inhabitant of the borders of fields and of woods in most soils which are not very wet. Its mode of growtli is much like that of the common creeper, the Ampelopsis quinquefolia of Michaux ; and like that vine, and the European Ivy, it would doubtless be cultivated for ornament, were 30 RHUS RADICATES. it harmless as it is handsome. As its name implies, this vine ascends upon tall objects in its neighbourhood by means of strong lateral rooting fibres, which project in great numbers from its sides, and attach themselves to the bark of trees and the surface of stones. The extreme branches of these fibres appear very strong in proportion to their fineness, and insinuate themselves into the minutest pores and crevices. The adhesion of the vine to the hark of trees is frequently so strong, that it cannot be torn off without breaking, and I have repeatedly seen large stems of the Hhus completely buried in the trunks of old trees, the bark having grown over and enveloped them. The fibres are analogous in their struc- ture to fine roots, and consist of a regular wood and bark. They are sometimes thrown out in such numbers on all sides, as to give the vine a shaggy appearance and conceal its bark. In general, however, they tend to tlie shady side, and are attracted toward opaque objects, furnish- ing an exemplification of Mr. Knight's beautiful explanation of motion in tendrils, which, by their propensity to avoid the light and approach the shade, are directed into contact with bodies capable of yielding them support. POISON IVY. 21 The size of the stem in this vine is commonly not more than an inch. Sometimes, however, in very old plants, it is found several times as large. It is usually compressed on the side which adheres to the support. In favourable situations it ascends to the tops of the highest rocks and trees, and is often seen restoring to decayed trunks the verdure which they have lost. When it does not meet with an elevated prop, the plant becomes stunted in its growth, is more branched, and affects a spiral mode of grow th ; or falls to the ground, takes root and rises again. The genus Rhus is placed by Linnaeus in the class Pentamhna, and order Trigynia. The present species, however, is dioecious, a fact which is also true of most of the American species of Rhus which I have examined. The Rhoes belong to the Linn&ean natural order Biimosw, and to the Terebintacew of Jussieu. The leaves of the Rhus radicans are ternate, and grow on long semicylindrical petioles. Leafets ovate or rhomboidal, acute, smooth and shining on both sides, the veins sometimes a little hairy beneath. The margin is sometimes entire and sometimes variously toothed and lobed, in the same plant. The flowers are small and greenish wliitc. They grow" in panicles or SS RHUS RADICANS. compound racemes on the sides of the new shoots, and are chiefly axillary. The barren flowers have a calyx of five erect, acute segments, and a corolla of five oblong recurved petals. Stamens erect with oblong anthers. In the centre is a rudiment of a style. — The fertile flowers, situated on a different plant, are about half the size of the preceding. The calyx and corolla are similar but more erect. They have five small, abortive stamens and a roundish germ surmounted with a short, erect style, ending in three stigmas. The berries are roundish and of a pale green colour, approaching to white. A plant has long appeared in the Pharmaco- poeias under the name of Mhiis toa^icodendron. Botanists are not agreed whether this plant is a separate species from the one under considera- tion, or whether they are varieties of the same. Linnseus made them different with the distinction of the leaves being naked and entire in Rhus radicans, while they are pubescent and angular in Ehus toxicodendron. Michaux and Pursh, whose opportunities of observation have been more extensive, consider the two as mere local varieties ; while Elliott and Nuttall still hold them to be distinct species. Among the plants which grow abundantly around Boston, I have POISON IVY. 33 frequently observed individual shoots from the same stock having the characters of both varieties. 1 have also observed that young plants of Ehus radicans frequently do not put out rooting fibres until they are several years old, and that they seem, in this respect, to be considerably influ- enced by the contiguity of supporting objects. The wood of the Poison Ivy is brittle, fine grained and white, with a yellow heart in the old plants. If a leaf or stem of tbis plant be broken off, a yellowish milky juice immediately exudes from the wounded extremity. After a short exposure to the air, it becomes of a deep black colour and does not again change. This juice, when applied to linen, forms one of the most perfect kinds of indelible ink. It does not fade from age, washing, or exposure to any of the common chemical agents. I have repeatedly, when in the country, marked my wristband with spots of this juice. The stain was at first faint and hardly perceptible, but in fifteen minutes it became black, and was never afterwards eradi- cated by washing, but continued to grow darker as long as the linen lasted. Dr. Thomas Horsfield, in his valuable disser- tation on the American species of Ehus, made 24i RHUS RAUICANS. various unsuccessful experiments with a view to ascertain the nature of this coh)uring principle, and the means of fixing it on stuffs. He found that the juice, expressed from the pounded leaves, did not produce the black colour, and that strong decoctions of the plant, impregnated with various chemical mordants, produced nothing more than a dull yellow, brownish or fawn colour. The reason of this is, that the colouring principle resides not in the sap, but in the succiis proprius or peculiar juice of the plant, that this juice exists only in small quantity, and is wholly insol- uble in water, a circumstance which contributes to the permanency of its colour, at the same time that it renders some other medium necessary for its solution. With a view to ascertain the proper menstru- um for this black substance, I subjected bits of cloth stained with it, to the action of various chemical agents. Water, at various temperatures assisted by soap and alkali, produced no change in its colour. Alcohol, both cold and boiling, was equally ineffectual. A portion of the cloth, di- gested several hours in cold ether with occasional agitation, was hardly altered in appearance. Sulphuric acid reddened the spots, but scarcely rendered them fainter. The fumes of oxymuriatie POISON IVY. 25 acid which bleached vegetable leaves and bits of calico in the same vessel, exerted no effect on this colour. Boiling ether is the proper solvent of this juice. A piece of linen spotted with the Hhus \ was immersed in ether and placed over a lamp. j As soon as the fluid boiled, the spot began to ; grow fainter, and in a few minutes was wholly | discharged, the ether acquiring from it a dark I colour. The linen at the same time became tinged throughout with a pale greyish colour, acquired from the solution. This nigrescent juice, in common with that of the Rhus vernix, has, perhaps, claims to be considered a distinct proximate principle in vegetable chemistry. The leaves and bark are astringent to the ^^ taste, which quality appears to be occasioned by gallic acid rather than tannin. The infusion and decoction become black on the addition of salts of iron, but discover hardly any sensibility to i gelatin. A poisonous quality exists in the juice ,and effluvium of this plant, like that which is found in the Ehus vernix already described. It is said, that some other species of Rhus, such as Rhus pumilum and Rhus typliinum, possess the same 4 26 RHUS RADICANS, propertj in a greater or less degree. The poison Ivj, however, appears to be less frequently inju- rious than the poison Dogwood, and many persons can come in contact with the former with impu- nity, who are soon affected by the latter. I have never, in ray own person, been affected by hand- ling or chewing the Rhus radicans, though the E,hus vernix has often occasioned a slight eruption. Indeed, the former plant is so commonly diffused by road-sides and near habitations, that its ill consequences must be extremely frequent, were many individuals susceptible of its poison. Those persons who are constitutionally liable to the influence of this poison, experience from it a train of symptoms very similar to those which result from exposure to the Blius vernix. These consist in itching, redness and tumefaction of the affected parts, particularly of the face ; succeeded by blisters, suppuration, aggravated swelling, heat, pain, and fever. When the disease is at its height, the skin becomes covered with a crust, aiM the swelling is so great as in many instances to close the eyes and almost obliterate the features of the face. The symptoms begin in a few hours after the exposure, and are commonly at the height on the fourth or fifth day ; after which, desqua- mation begins to take place, and the distress, in most instances, to diminislL POISON IVY. ^7 Sometimes the eruption is less general, and confines itself to the part which has been exposed to contact with the poison. A gentleman, vTith whom I was in company, marked his wristband with the fresh juice, to observe the effect of the colour. The next day his arm was covered with an eruption from the wrist to the shoulder, but the disease did not extend further. It sometimes happens that the eruption continues for a longer time than that which has been stated, and that one set of vesications succeeds another, so as to protract the disease beyond the usual period of recovery. The symptoms of this malady, though often highly distressing, are rarely fatal. I have nev- ertheless been told of cases in which death appeared to be the consequence of this poison. The disease brought on by the different species of Rhus appears to be of an erysipelatous nature. It is to be treated by the means which resist inflammation, such as rest, low diet, and evacuations. Purging with the neutral salts is peculiarly useful, and in the case of plethoric constitutions, or where the fever and arterial excitement are very great, blood-letting has been found of service. The extreme irritability and burning sensa- tion may be greatly mitigated by opium. Cold §8 RHUS RADICANS. applications, in the form of ice or cold water, are strongly recomraended by Dr. Horsefield in his treatise, and when persevered in, they appear to exert a remarkably beneficial effect. The^cetate_ of lead is perhaps as useful as any external palliative, and it should be used in solution rather than in the ointment, that it may be applied as cold as possible. The late Dr. Barton speaks highly of a solution of corrosive sublimate exter- nally applied in this disease, but from trials of the two remedies made at the same time and in the same patient, I have found the lead the more beneficial of the two. A person who has been in contact with the Shus and finds himself poisoned, should imme- diately examine his hands, clothes, ^c. to see if there are no spots of the juice adhering to him. These, if present, should be removed, as they will otherwise serve to keep up and extend the dis- order. From a want of this precaution, the disease is frequently transferred from the hands to different parts of the body, and likewise kept up for a longer time than if the cause had been early removed. As washing does not eradicate the stains of this very adhesive juice, it is best to rub them off with some absorbent powder. POISON IVY. 29 The Rhus radicans has been administered internally in certain diseases by a few practi- tioners in Europe and America. Dr. Horsefield, in several instances, administered a strong infusion in the dose of about a teacup full to consumptive and anasarcous patients. It ap- peared to act as an immediate stimulant to the stomach, producing some uneasiness in that organ, also promoting perspiration and diuresis. Some practitioners in the Middle States, we are told by the same author, have exhibited it with supposed benefit in pulmonary consumption. A French physician, Du Fresnoy, has reported seven cases of obstinate herpetic eruption, which were cured by the preparations of this plant. His attention was drawn to the subject by finding that a young man who had a dartre upon his wrist of six years' standing, was cured of it by accidentally becoming poisoned with this plant. The same physician administered the extract in several cases of palsy, four of which, he says, were cured by it. Dr. Alderson, of Hull, in England, gave the Hhus toxicodendron in doses of half a grain, or a grain three times a day, in several cases oi paralysis ; and states, that all his patients recov- ered, to a certain degree, the use of their limbs. 30 EHUS RADICANS. The first symptom of amendment was an un- pleasant feeling of prickling or twitching in the paralytic limbs. Dr Duncan, author of the Edinburgh Dispensatory, states, that he had given it in larger doses witliout experiencing the same success, although he thinks it not inactive as a medicine. My own opinion is, that the plant under consideration is too uncertain and hazardous to be employed in medicine, or kept in apothecaries' shops. It is true, that not more than one person in ten is probably susceptible of poison from it. Tet, even this chance, small as it is, should deter us from employing it. In persons not constitu- tionally susceptible of the eruptive disease, it is probably an inert medicine, since we find that Du Fresnoy's patients sometimes carried the dose as high as an ounce of the extract, three times a day, without perceiving any efifect from it. It is true that the external application of the E,hus radicans and Rhus vernix would, in certain cases, aiford a more violent external stimulus, than any medicinal substance with which we are acquainted. But since it is neither certain in its effect, nor manageable in its extent, the prospect of benefit, even in diseases like palsy and mania, is not sufficient to justify the risk of great evil. POISON IVY. 31 JBOTANICAL REFERENCES. Rhus radicans, Willd. Sp. pi. i. 1481. — Elliott, i. — Rhus toxicodendron, &c. Michaux, Flor. i. 183. — Pursh, i. 205. — Toxi- codendron rectum &c. — Dillenius, Elth. t. 291. MEDICAL REFERENCES. Du Fresno Y, quoted in Jlnnals of Medicine, iv. 182. — v. 483. — Med. and Phys. Journal, i. 308. — vi. 273. — x. 486. — Duncan, Dis- pens. 294 — ^Horsefield, Dissertation, Philad. 1798. PLATE XLIL g. 1. Rhus radicans, the barren plant in flower^ g. 2. Fruit. g. 3. Barren flower. g. 4. Fertile flower. g. 5, Petal. g. 6. Stamens and rudiment of a style in the barren floiver, g. 7. Germ, style and abortive stamens in the fertile flower. MYRICA CEEIFERA. Ifucv Myrtle. PLATE XLIIL Almost every region of the United States produces varieties of the Wax myrtle. Michaux considers them all as belonging to one species, a conclusion which is warranted by the great num- ber of intermediate sizes, and forms of leaf, which may he observed between the different extremes. Pursh, however, has chosen to distinguish three species which bear wax, and which he names cerifera after Linnseus, Caroliniensis from Will* denow, and Pennsylvanica from Lamarck. The Waoc myrtle or Bayherry, as it is often called, which is common in New England, varies in height from one to seven or eight feet. It is found in every kind of soil from the borders of swamps to the tops of barren hills, and is very much influenced in its size and appearance, by the place in which it happens to grow. I^LXLUr O ./^ r^rt^r rr'i'//<'7'n' WAX MYRTLE. S3 The genus Myrica belongs to the class Bioecia and order Tetrandria. It is also ranked among the Jlmentaceod of Linnaeus and Jussieu. The generic cliaracter consists in an imbri- cated ament ; the scales without a corolla ; the barren floivers containing four anthers, the fortile ones two styles. Fruit, one seeded^ — The spe- cific character, as given by Michaux, is as follows. Leaves wedge-lanceolate, with a fow serratures at top ; barren aments lax ; fruit spherical, naked, distinct. The Wax myrtle is found bearing fruit at every size, from the heiglit of one foot, to six or eight. In Louisiana, it is said to grow to twelve feet. The top is much branched, and covered with a grayish bark. The leaves are wedge- lanceolate, varying in width, sometimes entire, but more frequently toothed, particularly toward the end. They are somewhat pubescent, a little paler beneath, and generally twisted, or revolute in their mode of growth. They are inserted in a scattered manner by short petioles. The flowers appear in May before the leaves are fully ex- panded. 1 he barren ones grow in catkins, which are sessile, erect, about half an inch or three quarters long ; originating from the sides of the last year's twigs. Every flower is formed by a 5 34j myrica cerifera. concave rhomboidal scale, containing three or four pairs of roundish anthers on a branched footstalk. The fertile flowers, which grow on a different shrub, are less than half the size of the barren ones, and consist of narrower scales, with each an ovate germ, and two filiform styles. To these anients succeed clusters or aggre- gations of small globular fruits resembling berries, which are at first green, but finally become nearly white. They consist of a hard stone inclosing a dicotyledonous kernel. This stone is studded on its outside with small black grains resembling fine gun-powder, over which is a crust of dry white v/ax, fitted to the grains and giving the surface of the fruit a granulated appearance. Botanically speaking, this fruit has been im- properly called a berry, and a drupe ; since it is always dry and never invested with a cuticle, or any thing but the grains and wax. Every young part of the Wax myrtle has a fragrant, balsamic smell, which it communicates to the fingers when rubbed by them. This appears to be derived from a resinous exudation, which may be seen in minute points of a bright transparent yellow, covering the young shoots and under surface of the leaves. In the berries this resinous substance is within the wax. WAX MYRTLE. 35 The bark and leaves of the Myrica cerifera contain gallic acid, tannin, resin, and a small quantity of mucilage, which are manifested by their usual tests. The wax of the Myrica is obtained for com- mon purposes by boiling large quantities of the berries in kettles with water enough to cover them to the depth of several inches. The ber- ries, which float at first, gradually subside to the bottom when the wax is melted off, which latter substance floats on the surface. When the boiling has been continued long enough to divest the berries of most of their wax, the liquid is suffered to cool, and the wax concretes on the top. It is purified by melting it anew, and is then cast into masses. In this state it is of a greenish gray colour, with a consistence which is intermediate between that of bees wax and tallow, being brittle and not remarkable for adhesiveness or unctuosity. It burns with a white flame, which is less vivid than that of tallow or whale oil. The cliemical properties of this wax have been examined by M. Cadet, in France, and Dr. Bostock, in England. From their experiments, we learn that water has no action on the Myrtle wax, either cold or at the boilina* heat. Dr. 36 MYRICA CERIFERA. Bostock informs us that alcohol, at the ordinary temperature of the atmosphere, has no action upon it ; but one hundred parts by weight of the fluid, when boiling, dissolve about five parts of the wax. About four fifths of this is deposited by cooling, and the rest is slowly deposited in a few days, or may be precipitated by water. Of the mass of wax, a certain portion remains insol- uble in alcohol. Sulphuric ether, according to Dr. Bostock, dissolves but little of the wax, when cold, but acts upon it rapidly, when boiling, taking up somewhat more than one quarter of its own weight. Upon evaporation, the wax is deposited in a crystalline or lamellated form, its texture resembling that of spermaceti. — Rectified oil of turpentine, when assisted by heat, dissolves about six per cent of its own weight, most of which is deposited on cooling. — Pure potash, in water, renders the wax colourless by boiling, and forms a soap with a small part, which may be decom- posed by an acid, and affords' the wax nearly un- changed. — The sulphuric acid, assisted by heat, dissolves about one twelfth of its own weight, and forms a dark brown mass. The nitric and muriatic acids exert very little action upon it. Dr. Bostock considers the Myrtle wax to be a fixed vegetable oil, rendered concrete by oxygen. WAX MYRTLE. 37 M. Cadet, in addition to many of the above characteristics of Myrtle wax, found that it com- bined readily with the semivitreoiis oxyde of lead, forming a very hard plaister. When distilled in a retort, the wax was partly decomposed, and a portion which passed over was white and of a soft consistence. Oxygenated muriatic acid bleaches it, but with more difficulty than bees wax. The experiments which I have made on this substance confirm the preceding statements with the following exceptions. Cold alcohol dissolves a minute portion, which is gradually separated by the addition of water, and floats in perceptible flocci, near the surface. Cold ether dissolves about one sixteenth of its weight. Tliis it does with great rapidity, and if thin shavings of the wax be dropped into a vessel of ether, they disappear almost immediately. Dr. J. F. Dana has published, in Silliman's Journal, an account of some experiments made to ascertain the proportion of wax, and of tbe other parts which compose the entire berry. He found the wax to constitute nearly a third of the whole, or thirty two per cent ; the kernels 47.00, the black powder 1^.00, with about d.OO of a resino-extractive matter. 38 MYRICA CERIFERA. There undoubtedly exists, in the berries of this shrub, some interesting constituents beside the wax and insoluble portions, as the following results will show. If water be distilled from the fresh berries, it acquires a slight pearly appear- ance and a fine aromatic odour and taste. This indicates the presence of a volatile oil, though I have not performed the experiment sufficiently in the large way to obtain any oil separate. The decoction remaining in the retort gives proofs of gallic acid. When the wax, in a separate state, is boiled in alcohol, a portion is dissolved, which is mostly deposited on cooling, leaving the fluid clear. But if alcohol be boiled upon the berries till a strong solution is formed, it does not give a deposit on cooling, but the solution coagulates into a soft solid and remains afterwards unaltered. This coagulum is readily soluble in cold ether, and melts when exposed to heat. If the berries be boiled in water until the wax is melted and principally detached, the remaining parts still give a coagulating solution with alcohol. — The tincture made by digesting cold alcohol on the bruised berries is considerably coloured, and becomes turbid on the addition of water, but whether the resinous sybstance thus precipitated WAX MYRTLE. 3^ is the same in small quantity, which produces the coagulation in a large one , I am not pre- pared to say. It appears, then, that there exists in the berries of the Myrica a peculiar vegetable prin- ciple, bearing nearly the same relation to alcohol^ as starch and gelatin do to water. I have not yet obtained it in a separate state, and cannot there- fore give any additional characteristics to those which have been already stated. The Myrtle wax is useful for many of the purposes for which bees wax and tallow are employed, particularly for candles. It burns with a clear flame, though less vivid than that of common oil, and emits a considerable fragrance. It was formerly much in demand as an ingredi- ent in a species of Macking ball, to which it com- m^unicated a tempori^'y lustre and power of re- pelling water. It has occasionally been used in pharmacy in various compositions intended for external use, aod is mild or stimulating according as it is more or less pure and freed from the colouring matter. In some parts of Europe plantations of this shrub have been raised with a view to the profit to be derived from the wax. In this country, where the shrub abounds, the berries are often 4^0 MYRICA CERIFERA. neglected, their collectioQ and the separation of the wax being deemed too laborious to compen- sate the trouble. In Dr. Thatcher's Dispensatory, we are in- formed, on the authority of Dr. Mann, that the bark of the root of the Mjrica cerifera is emetic. With a view to examining thoroughly its medici- nal properties, Dr. S. L. Dana, in 1818, made it the subject of an inaugural dissertation. He found that the powdered bark was acrid and as- tringent, but did not appear to possess any other qualities than were attributable to those two. Moderate doses of the powder and decoction pro- duced no effect on the stomach or bowels. Large doses, for instance two scruples, were swallowed with difficulty on account of their acrimony, and occasioned heat and nausea at the stomach. Larger doses, of a drachm, produced a powerful burning sensation and vomiting. Costiveness generally followed the use of this medicine. The powder, when snuffed up the nose, proved pow- erfully sternutatory, and when applied to the fungous granulations of an ulcerated leg, it pro- duced so much pain as compelled the patient to wash it off. Yf e may then consider the bark of the Myrica as an acrid stimulant and astringent. That it WAX MYRTLE. 4i scunetimes proves emetic, in large doses, is to be explained in the same way as tlie operation of mustard and horse-radish, which some of the older physicians employed as emetics. "When the stomach is burdened with an undue quantity of stimulus, it naturally tends to relieve itself by vomiting. On the whole, we are to esteem the Myrica cerifera as more interesting in a chemical, than a medical point of view. The pleasant aroma of the water distilled from the berries, and the ap- plication of the wax to some purposes of phar- macy, are all, that this shrub at present offers, much deserving the attention of physicians. BOTANICAL REFERENCES. Myrica cerifera, Willd. iv. 745. — Michaux, ii. 227. — Pursh^ ii. 620. — Myrtus foliis lanceolatis, &c. — Gronovius, 155.— Myrtus brabanticse similis, &c. — Catesby, i. 13 ? MEDICAL AND CHEMICAL REFERENCES. Cadkt, translated in JSTicliohon's Journal, 8^'o. vol. iv. 187.—= BosTocK, in ditto, 129. — Kalm, Travels, i, 129. — Dana, in Silliman's Journal, vol. i. — Thacher, Disp. 288. 6 4^ MYRICA CEllIFERA. PLATE XLIII. Fig, 1. Myrica cerifera, with fruit not fully ripe. Fig. 2. Jl barren branch in flower. Fig. 3, Fertile ditto in flower. Fig. 4. Jl barren flower. Fig. 5. The same with the scale turned down, shewing the mode of growth of the anthers. Fig. 6. Fertile flower. Fig. 7. Fruit somewhat magnified. j}ir^^y^<'^^^' ^^'''''''' /?fj JUNIPEEUS COMMUNIS. Common Juniper. PLATE XLiv:^ A HE prostrate variety of the common Juniper is so peculiar in its mode of growth, that it has some claims to he considered a distinct species. On comparing it, however, with European speci- mens, I find the similarity so great, that I do not see sufficient grounds for separating it, especially as there are, in Europe, several varieties in size and mode of growth, which are not recognized as separate species. The variety, which is the only one I have met with in the Northern States, is a large trailing shrub, continually throwing out roots from its branches, and spreading in all directions until it forms beds, which are many rods in circumference. In this way it continues to advance outward, supporting itself by new roots even after the original trunks, at the centre, * Very beautiful drawings, froui which this and the following plate are engraved, were sent me by a lady in Hampshire county. 44 JUNIPERUS COMMUNIS. are dead and decayed. It seldom rises more thaii two or three feet from the ground. The genus Juniperus belongs to the class Dioecia, order Monadelphia, and natural order Coniferce of Linnaeus and Jussieu. It is distin- guished by an ovate anient with peltate scales, which, in the barren flowers, are whorled in threes^ with from two to four anthers ; in the fertile ones opposite. Berry three seeded^^-^ln the common Juniper, the leaves are ternate^ spreading^ mucro^ nate, larger than the herry. The Juniper is with us always a shrub, never rising into a tree. The tips of the branches are smooth and angular. The leaves grow in threes and are linear-acerose, sharply mucronate, shining green on their lower surface, but with a broad glaucous line through the centre of the upper. These leaves, however, are always resupinate, and turn their upper surface toward the ground. The barren flowers grow in small axillary aments, with roundish, acute, stipitate scales, inclosing several anthers. The fertile flov/ers, growing on a separate shrub, have a small, three parted calyx growing to the germ ; and three styles. The fruit is a fleshy, roundish, oblong berry, of a dark purplish colour, formed of the germ and conflu- ent calyx, marked with three prominences or COMMON JUNIPER. 45 resides at top, and containing three seeds. It requires two seasons to arrive at maturity from the flower. The leaves of the Juniper have a strong and rather unpleasant taste, with a little astringency. The peculiar juice of the bark appears to consist of resin and volatile oil. Gum Sandarach, which fns'nishes the material of pounce, is obtained from the European Juuiper, from which it exudes spontaneously through crevices and perforations in the bark. The part principally used in medicine is the berries. These have a strong peculiar taste, accompanied with considerable sweetness. When long chewed, they leave an impression of bitter- ness. The sweetness appears to reside in the pulp, the bitterness in the seeds, or in their im- mediate investment, and the aromatic flavour in the essential oil.. Dr. Lewis observes, that tinc- tures, made with these berries, differ according as they are prepared with the berries entire or bruised. When of a good quality these berries yield, in distillation, a large quantity of pungent, volatile oil of a peculiar flavour, the same which it com- municates to gin. The medicinal powers, for which this article is employed, may be considexed as residing in this oil. ^^. JUNIPERUS COMMUNIS, The berries of the Juniper have long been employed for the purposes of a diuretic, particu- larly in dropsy. Many of the older writers, whose names are of high authority in medicine, have given favorable reports of the operation of this medicine in hydropic cases. It has been used in substance, in infusion, and in various compound medicines. The effects of its most popular prepara- tion, that of an ardent spirit, are too universally known to require particular ekicidation. In addi- tion to the specific effect of the essential oil, some physicians have attributed virtues to the rob, or inspissated decoction of the berries. Hoff- man found it of great use in debility of the stomach and intestines, particularly in old people. The stronger preparations have been found useful in uterine obstructions, and in paralytic affections of the vesica urinaria. Linnseus informs us, in his Flora Lapponica, that a fermented decoction of Juniper berries is used in Sweden as a common drink, but he denies the infusion being substituted for tea and coffee, as some writers have stated, in Lapland. Wood- ville and others have misquoted him on this point. The American Juniper berries are considera* bly inferior to the European in strength and COMMON JUNIPER. 47 flavour. The best of the latter are said to be from Italy. But of the imported specimens, which I have examined at the druggists' shops in this country, very few possess any remains of the original strength, and much the greater portion of them appear to have undergone at least one distillation, before their exportation from Europe. The best Juniper berries have a strong impregnation of volatile oil, which, having been once tasted, cannot be easily mistaken. Those which have been subjected to distillation are dry and tasteless. BOTANICAL BEFERENCES. Juniperus communis, Linn. — Smith, Flor. Brit. iii. 1085. — EngL Bot. t 1100. — WooDviLLE, ii. t. 95. — Michaux, ii. 245. — .Pursh, ik 646. — Blackwell, t. 187. MEDICAL REFERENCES. MuiiRAY, Jlp2J. Med. i. 34. — Lewis, Disp, 240. — Linnaeus, Flora Lapj). 376. — WooDviLLE, ut supra. 48 JUNIPERUS COMMUNIS, PLATE XLIV. Fig. 1. A hrancli ofJuniperiis communis in fniih Fig. 2. A barren twig in flower. Fig;. 3. Barren ament. Fig. 4. Scale of anthers of the same-. Fig. 5. ' Fertile flower. JUNIPERUS VIRGINIANA. Red Cedar, PLATE XLV. Unlike the subject of the preceding article, this species rises into a tree of considerable size. It is the largest of the Junipers growing within the original limits of the United States, though it appears that Lewis and Clarke brought home specimens of a loftj tree, with foliage resembling the Savin, found on the banks of streams among the Rocky mountains, and which is supposed to be the same with J. excelsa, growing in Siberia. Michaux, in his North American Sjlva, in- forms us, that it is found from Maine and from Lake Champlain, without interruption to the Cape of Florida. In the Middle and Northern states, it frequents the most barren soils, being found in abundance upon dry, rocky hills, where scarcely any other tree can subsist. Its size, however, is said to be here inferior to that which it attains in Virginia, and farther south. 50 JUNIPEllUS VIRGINIANA. Its habit and foliage abundantly distinguish it from the species in the last article. From the Juniperus Sabina, or common Savin of Europe, its botanical distinction is by no means easy. The general appearance and arrangement of the leaves in the full grown specimens of both is precisely the same, except that in the Red cedar the leaves are shorter and more compactly im- bricated, having an ovate form, while in the Savin they are somewhat longer and more remote, and may be called lanceolate. In the Red cedar they are also more universally and pungently acute. The characters of the latter species, which I have seen given by different botanists, are almost all defective, in ascribing to it ternate kaves, which, I believe, never exist except in imperfect or distorted specimens. Its more true .character is as follows. Trunk arboreous, upper leaves imbricated in four rows, ovate, pungently acute. It is by no means certain that on mature examination all the present species of Juniper will be found sufficiently distinct to be kept separate. The Red cedar, when full grown, is a middling sized tree, though, on account of the value of its wood, it is seldom suffered to reach its full dimen- sions. The trunk is straight and decreases rapidly IIED CEDAR. 51 from the ground, giving off many horizontal branches. Its surface is generally unequal, and disfigured by knots, and the crevices and protu- berances they occasion. The small twigs are cov - ered with minute, densely imbricated leaves, which continue to increase in size as the branch groAVS, till they are broken up and confoundetl with the rough bark. These leaves are fleshy, ovate, con- cave, rigidly acute, marked, with a small depressed gland on tlie middle of their outer side, growing in pairs, which are united at base to each other, and to the pairs above and below them. They do not alter their situation, but continue opposite till they are obliterated by age. A singular variety sometimes appears in the young shoots, especially those which issue from the base of the trees. This consists in an elongation of the leaves to five or six times their usual length, while they become spreading, acerose, considerably remote from each other, and irregular in their insertion, being either opposite or ternate. These shoots are so dissimilar to the parent tree that they have repeatedly been mistaken for individuals of a different species. — The barren flowers grow in small oblong aments, formed by peltate scales with the anthers concealed within them. The fertile flawers have a proper perianth, which 53 JUNIPERUS yiRGINlANA, coalesces with the germ and forms a small round- ish berry, Avith two or three seeds, covered on its outer surface with a bright blue powder. The leaves of the Red cedar have a strong disagreeable taste, with some pungency and bitterness. The peculiar taste and odour reside, no doubt, in a volatile oil, which, however, is not readily separated by distillations in a small way. The tincture becomes turbid ^vhen water is added, and very much so if suffered to stand a day or two. The presence of tannin is devel- oped by the admixture of dissolved isinglass, >vith a decoction of the bark and leaves. The botanical similarity of this tree to the Savin, which is an European shrub, has already been mentioned. In their sensible and medicinal properties, they are equally allied. The taste of the two species is nearly the same, except that the cedar leaves are the more nauseous of the two. As the American tree is frequently known throughout the country by the name of Savin, our apothecaries have been led to presume upon its identity with that medicine, and it has long been used in cases where the true Savin is recom- mended. Its most frequent use, however, is in the composition of the cerate employed for keep- ing up the irritation and discharge of blisters. RED CEDAR. 52 This preparation is the same with the Savin cerate, used in Europe, the leaves of the Red cedar being substituted for those of the Savin. When properly prepared by boiling the fresh leaves for a short time in about twice their weight of lard with the addition of a little wax, a cerate is formed of • peculiar efficacy as a perpetual epispastic. When applied as a dressing to a newly vesicated surface, and afterwards repeated twice a day, it rarely fails to keep up the dis- charge for an indefinite length of time. Under its operation, the discharge usually changes from a serous to a puriform appearance, and concretes upon the surface ; so that it requires to be re- moved from time to time, to admit the full action of the cerate. Internally the leaves of the Juniperus Virgin- iana have been found to exert effects very similar to those of the Savin. They have proved useful as an emmenagogue, and as a general stimulant and diaphoretic in rheumatism. They have also liad some reputation as a diuretic in dropsy. The wood of the Red cedar is smooth, light, and \evj durable. Its alburnum is white, but the heart wood of a beautiful red colour, whence its name is derived. It is principally employed for posts in fences, in which capacity it proves 54! JUNIPERUS VIRGINIANA. more du-able than almost any species of wood used for the same purpose. BOTANICAIi REFERENCES. Juniperus Virginiana, Willd. iv. 8€2,— -!Pursh, ii. 647.— Mi- CHAuXjjfiL JV. d. Sylva, t. 155. MEDICAL REFERENCE, Thacher, Disp. 247. PLATE XLV. Fig. 1. Juniperus Virginiana in fruit. Fig. 2. Variety with long leaves. Fig. 3. Barren branch in flower. Fig. 4. Barren anient magnified, Fiff. 5. Scale and anthers. 7V. mm^ ._ ^5^y2^' Ni m ^/r/y/rr//r/r^/^'^ /V//4*//'/'^ RANUNCULUS BULBOSUS. Bulbous Crowfoot. PLATE XLVIL J.T is a remarkable fact that a great portion of the weeds, which are most troublesome in the United States, are of European origin, having intruduced themselves since the discovery of th^s country. Some of these emigrants have settled in our grazing and mowing lands, such as the Ranunculus bulbosus, acris and repens, indis- criminately called Buttercups, Crowfoot, and Tellow weed; the Chrysanthemum leucanthe- mum, or White weed; the Rumex acetosella, or Sorrel; the Hypericum perforatum, or St. John^s wort, ^c. In our cornfields and gardens are quartered the Couch grass, Triticum repens , the different species of Goosefoot or Pig weed, Che- nopodium ; the Bock, Rumex crispus, ^c. ; the Charlock or Wild Radish, Raphanus Raphanis- trum j Burdock, Arctium lappa, ^'c. Some have 62 RANUNCULUS BULEOSUS. commenced their inroads within a few years, such as the Cnicus arvensis, improperly called Canada thistle ; the Genista tinctoria or Byer^s weed, §c. — In retnrn for these introductions, we have sent them the Erigeron Canadense, and the prolific families of Ambrosia and Amaranthus. No race of plants is more familiarly known than the Eanunculi. Of numerous species, both native and imported, which we possess ; several resemble each other so nearly, as to pass with common observers for the same plant. The great similarity of their properties renders it almost unnecessary in a medical or economical point of view to distinguish them. I have selected the bulbous-rooted species, not because it is more active in its properties than many others, but because it is one of the most common and best known. The genus belongs to the class Polyandria, and order Foly^ynia. It is found in the natural orders Multisiliquoe, Linn, and Banimculacew, Juss. Its generic character is formed by a jive leaved calyoc ; five petals, with a melliferous pore at the base of each ; the seeds naked. No genus can be more strictly natural than this. A general resemblance pervades the whole of the species, which indicates their consanguinity at sight. BULBOUS CROWFOOT. 63 The nectary, the never failing concomitant of this genus, is a small cavity at the inside of the claw of each petal, generally covered by a flat scale, sometimes surrounded with a concave brim, and at others inclosed in a short cylinder. A subtle and violent acrimony, on which the medical properties seem to depend, is found in most, if not in all, of the species. The species bulbosiis has coinpoimd leaves^ mi erect many flowered stem^ a furroived peduncle^ rejlejoed calyiv, and bulbous root. It grows gen- erally in dry pastures, mowing lands and road sides, flowering abundantly in May and the first part of June, after which it gives place to its equally abundant successors, E. acris and repens, which, however, generally prefer a more moist soil. These three species, having flowers of similar size and appearance, are indiscriminately known by the name of Buttercups. Then* distinction affords a pleasing instance of different combina- tions of features, forming separate characters for similar plants. The R. bulbosus has a furrowed flower-stalk and reflexed calyx ; B. repens a furrowed flower-stalk and spreading calyx, and B,. acris a round flower-stalk and spreading calyx. 6# RANUNCULUS BULBOSUS. A more particular description of the plant in our figure is as follows. Boot fleshy, solid, roundish, depressed, sending out radicles from its under side. In autumn it gives off lateral bulbs near its top, which afford plants for the next year, while the old root decays. Stems several, erect, round, hairy, branching. Root leaves on long petioles, tern ate, sometimes quinate ; the segments variously cut, lobed and toothed ; hairy. Stem leaves sessile, temate, the upper ones more simple. Flowers several on a stem, solitary, of a bright glossy yellow. Pedun- cles furrowed, angular, hairy. Calyx leaves oblong, hairy, bent back against the peduncle. Petals five, inversely heart shaped ; the nectary at the claw covered with a small wedge-shaped emarginate scale. Stamens numerous, yellow, with oblong erect anthers. Germs numerous with reflexed stigmas. Fruit a spherical head composed of acute, naked, diverging seeds with recurved points. The roots of Ranunculus bulbosus appear to consist principally of albumen intermixed with ligneous fibres. If the root be macerated in cold water, it gives a solution of this substance, which coagulates in flocks on the application of heat; and undergoes the same process slowly on the BULBOUS CROWFOOT. Q5 admixture of alcohol. But the most interestinar constituent in this, and in most other species, is the acrid principle which pervades every part of the plant in its green state. Like the acrimony of the Arum, it is volatile, and disappears in dry- ing, or upon the application of heat. It differs, however, in not being destroyed by a moderate heat, and in being fully preserved in distillation. I have subjected various species of Ranunculus to this experiment, and always found the distilled water to possess a strong acrimony ; while the decoction and portions of the plant remaining in the retort were wholly destitute of this property. This distilled water, when first taken into the mouth, excited no particular effect ; but after a few seconds a sharp, stinging sensation was always produced. When swallowed, a great sense of heat took place in the stomach. I pre- served some of the water distilled from leaves of Eanunculus repens, for several months in a close stopped pliial ; during which time it retained its acrimony undiminished. In winter time it froze, and on thawing had lost this property. Tilebein, as quoted by I)r. Pulteney, in some experiments on this genus of plants, found that water distilled from a. sceleratus, on cooling, deposited small crystals, which were hardly soluble in any men- 66 RANUNCULUS BULBOSUS. struum, and were of an inflammable natm^e. 1 have not met with an appearance of this kind. The distilled water, however, had a substance dissolved in sufficient quantity to yield a gradual precipitate with some reagents, such as muriate of tin and acetate of lead. The strength of the distilled water is impaired by continuing the op? ration too long. 1 he acrimony of the plant is expended in a very short time at the boiling heat, and a farther continuance of the distillation brings over only water. Since the time of Dioscorides [JVofe A.] the acrid and stimulating properties of the Ranunculi have been well known. This acrimony resides in all the species, with the exception of JR. aiivi- comus, which is said to be mild, and perhaps two or three others. It is so powerful that it speed- ily inflames or corrodes the lips and tongue, if kept in contact with them. In the nostrils it acts as a violent sternutatory, and if swallowed in considerable quantity, it brings on great pain, heat and inflammation of the stomach, and has even occasioned convulsions and death. Before the introduction of Cantharides as a vesicatory, different species of Ranunculus were used upon the skin, as external stimulants. Their power of occasioning erosion and ulceration BULBOUS CROWFOOT. 67 appears to have been known to the ancients. Different medical writers have given accounts of their mode of operation ; but the most extensive history and investigation is that of Krapf, pub- lished at Vienna, in 1766. This work, which I have not seen, is quoted in all its principal facts by Professor Murray of Gftttingen in the Appara- tus medicaminum. According to this author the various species, with which his experiments were made, proved capable of exciting inflammation, blistering and ulceration, when applied to the skin. A slice of the fresh root of R. bulbosus placed in contact with the inside of the finger, brought on a sense of burning in two minutes. When taken off, the skin was found without red- ness, and the sense of heat and itching ceased. In two hours, however, it returned again, and in ten hours a full serous blister was raised. This was followed bv an ulcer of bad character and difficult to heal. He remarks that, if the appli- cation is continued after the first itching, the pain and subsequent erosion is much greater. From the accounts given of this species, also of R. sceleratus, H. acris, and some others, it appears that the leaves, flowers, buds, or roots of these plants, if bruised and applied to the skin, excite redness and vesication. This effect is not &8 RANUNCULUS BULBOSUS. constant, but fails to take place in certain con- stitutions or at certain seasons of the year, (xenerally, however, they are said to operate in half an hour, or less, from the time of their appli- cation. They are stated to possess the advantage over blisters made by flies, that they never occa- sion symptoms of strangui'y. With a view to their external stimulus they have been used advantageously in rheumatism, the hip disease, hemicrania, and fixed pains of various descriptions. Among the old practition- ers, who have recorded instances of their effects, are Baglivi, Storck, and Sennertius. A curious practice, at one time, prevailed in several coun- tries in Europe, of applying the Ranunculus to the wrists or fingers, for the cure of intermittent fever. This is mentioned by Yan Swieten, Tissot, and some others. In hemicrania it was applied to the head, and in this case it did not produce a discharge, nor break the skin ; but occasioned tumefaction of the hairy scalp. An objection against the use of the Eanunculi, as external stimulants, exists in the uncertainty of their operation, and the violent effects which sometimes have followed after they had been ap- plied. Those writers, who have witnessed their application, record instances in which these vege- BULBOUS CROWFOOT. 09 table blisters have been followed by deep, ill- conditioned and slongbiug ulcers, which were not healed without great difficulty. Tissot mentions an instance, in which an application made to the thumb caused a deep, painful ulcer, which pene- trated to the bone, and occupied some months in its cure. In another case the blister spread, in a few hours, over the whole arm, occasioning fever and delirium, and was followed by such a tendency to gangrene, that the limb was with difficulty saved. Chesnau, quoted by Murray, advises that the Eanunculus should be applied to a small surface only, and through a perforation in an adhesive plaister, to prevent it from spread- ing. From want of this caution, he had known extensive inflammation to arise and spread over a greater part of the face, neck, and breast. — Linnseus, in his Flora Suecica, relates that beg- gars, in Sweden, were known to excite ulcerations of their feet with the Eanunculus sceleratus, to assist them in extorting charity from passengers. I know not to what extent the efficacy of the Ranunculi, externally applied, can be depended on. Certain it is that they do not affect all persons alike, and this fact is avowed by those who have used them most. I have repeatedly made applications of the contused roots and fO RANUNCULUS BULBOSUS. leaves of different species to my arm and hand^ and worn them for a dozen hours, without feeling any particular sensation, or perceiving any visible eifect. The rapid drying up of the moisture of the plant seemed to prevent it from acting upon the skin. I am inclined to believe, there is something in the action of these vegetables anal- ogous to that of the poisonous species of Rhus described in this work ; which some individuals, but not all, are susceptible of. The extensive and spreading inflammation, which they occa- sionally produce, resembles more the effect of these shrubs, than of any of the ordinary rube- facients or vesicants. The burning sensation which the Ranunculi excite in the mouth when chewed, extends to the stomach if they are swallowed. Krapf states that a small portion of a leaf or flower of R. sceleratus, or two drops of the juice, excited acute pain in the stomach, and a sense of inflam- mation in the throat. He gave a large quantity of the juice to a dog, which brought on vomiting and great distress ; and the animal being killed, was found with the stomacli inflamed and con- tracted, and the pylorus hardly pervious. The same author informs us that dilution greatly diminishes the power of this fluid, so that half a BULBOUS CROWFOOT. 71 drachm of the juice, in six ounces of water, may be taken with entire safety. Dr. Withering, as quoted by Dr. Pulteney in the Liiinsean transactions, asserts, that the dis- tilh'd water of Ranunculus flammula is an emetic more instantaneous and less offensive than sul- phate of zinc. I know not in what publication of Dr. W. this statement is made, but the fact appears to me not improbable. Acrid substances, sucli as mustard, pepper, and horse-radish, if swallowed in large quantities, excite the stomach to relieve itself by vomiting. An objection, however, exists against the distilled water, owinsc to the uncertainty of its strength ; which must vary in proportion to the quantity of the plant employed, the time occupied in distillation, and the subsequent time for which the fluid is kept. Krapf states that R. auricomus and R. lanugi- nosus are so free from acrimony, that they are eaten as greens or sallads. All the species lose their pungency in boiliog, so that even the R. sceleratus, one of the most acrid, is used for the same purpose. Grazing cattle generally avoid the plants of this genus, which grow among grass, as far as it is possible for them to do it. Accordingly we observe the flowers of Ranunculi left untouched. f^ llANUNCULUS BULBOSUS. while the grass is closely cropped around them. It is nevertheless unavoidable, so common are these plants, that portions of them should be eaten very often by these animals. It is probable that small quantities of the less acrid sorts do them no injury. At least, it appears that their stomachs are much less susceptible to this kind of stimulus than ours. In the Pan Suecus some experiments upon these plants, with domestic animals, are detailed ; in which, it is stated that, horned cattle refused to eat all the species when offered to them, except R. auricomus. This species was rejected by horses, while they would eat R. flammula. Sheep and goats eat the R. acris, one of the most pungent species. Dr. Pulteney states, as a well known fact, that hogs. in England, devour the roots of R. bulbosus. How it is that these animals resist the deleterious effects of so virulent plants, it is not easy to say. It is, however, a not more remarkable fact, than the power of some animals to devour CantharideS and even mineral poisons with impunity.* In their dry state, various species of Ranun- culus enter into the composition of hay, particu- larly R. acris. Having lost their acrimony altogether in drying, they are haniiless and probably nutritive. * See a notCj vol. i. p. 164. BULBOUS CROWFOOT. 73 I)r. Pulteney has published a memoir in the Liiiiiffian transactions on the economical use of some of the Ranunculi, particularly the R. fluvia- tilis, which he considers a variety of R. aquatilis. Contrary to the common effects of the other species, this plant is said, by him, to be not only imiocent, but highly nutritive to cattle. He states that, " in the neighbourhood of Ringwood, on the borders of the Avon, which affords this vegetable in great abundance all the year, some of the cottagers sustain their cows, and even horses/ almost wholly upon this plant ; since the remain- ing part of their food is nothing more than a scanty pittance, they get on the adjacent heath, which affords little more than Ling, Lichen, Bog- moss or Sphagnum, ^c. It is usual to employ a man to collect a quantity for the day every morning, and bring it in the boat to the edge of the water, from which the cows, in the instance seen, stood eating it with great avidity. I was indeed informed," says he, " they relished it so highly, that it was unsafe to allow them more than a certain quantity; I think between twenty five and thirty pounds daily, ea* h ; but with variation according to circumstances. The cows I saw were apparently not in a mean condition, and gave a sufficient quantity of good milk. I 10 74 RANUNCULUS BULBOSUS. was told by tlie person whose cattle were feeding on it, that he kept five cows and one horse so entirely on this plant and what the heath afibrded, that they had not consumed half a ton of hay throughout the whole year ; none being used except when the river was frozen over. I exam- ined the whole parcel on which four cows were feeding, in the beginning March, and found the whole consisted exclusively of the Ranunculus fluviatilis without any mixture of the Potamoge- ton, Carex, Sparganium, or other aquatic plants. In summer, however, it can hardly be avoided but that there must be a mixture of some of these, but other plants are not chosen. " This account was confirmed to me by dififer- ent persons ; by whom I was further informed that hogs are also fed with the same plant, on which they improve so well, that it is not neces- sary to allow them other sustenance, till it is proper to put them up to fatten." In Veterinary practice the Ranunculus bul- bosus has been employed as an external stimu- lant. To this purpose Dr. Chapman, in his Therapeutics, thinks it may be better adapted than other topical excitants. BULBOUS CROWFOOT. 75" BOTANICAL REFERENCES. Ranunculus bulbosus, Linn. Sp. pi. — Curtis, Flora Lond. i. 38. — Mautyn, F/ora rziSitica, f. 28. — Smith, Flora Britt. 591. — Engl. Bot. t. 515. — MicHAUx, i. 321. — Pursh, ii. 393. — Ranunculus tube- rosus magor, J. Bauhin, iii. 417". — Ranunculus pratensis, &c,— (Eder, FL Dan. t. 515. MEDICAL REFERENCES. Murray, Apparatus, Med. iii. 88. — Krapf. Ranunculi. Vienna, 1 766,— Lewis, Mat. Med. ii. 262.— B. S. Barton, 23.— Pulteney, Lin. transactions, v. 14. — Chapman, Therapeutics, ii. 411. PLATE XL VII. Fig. 1. Ranunculus bulbosus, the radical leaf of the largest size and more subdivided than common. ^ Fig. 2. Radical leaf of siualler size and more common shape. Fig. 3. Petal and nectary. Fig. 4. Two stamens enlarged. Fig. 5. Fruit. ILLICIUM FLOEIDANUM, Starry Anise, TLdTE XLVIII, J. HE same qualities which entitle the Lirio- dendron and Magnolias to a place among medi- cinal plants, exist abundantly in the kirtdred genus of lllicium. Ihis familj consists of fine, spicy, flowering shrubs, one of which, the I. anisatum, growing in Eastern Asia, derives its name from the similiarity of its flavour to that of Anise, a quility which exists, though less simple, in the subject of the present article. Another species, the I. parviflorum, a shrub with small yeUowish flowers, first discovered by Michaux in the mountains of Georgia and Carolina, has so exactly the flavour of the Sassafras root, that they are not to be distinguished by the taste. The I. Floridanum forms beautiful thickets in the country bordering on the north of the Gulf of STARRY ANISE. 77 Mexico, and is often mentioned by the traveller Bartram, with his accustomed enthusiasm, as one of the chief beauties of that exuberant region. In the Northern states, as well as in Europe, it is preserved by artificial heat. The drawing, which illustrates our description, was made from a greenhouse specimen. The character assigned to this genus is formed by a sia? leaved ealya^, twenty seven petals^ and a number^ of capsules arranged in a circle, ttvo valved, one seeded. The species Floridaniim has its leaves acuminate and its petals numerous^ oblong and linear. The class and order are Polyandria, Folygy- nia; and the Natural orders Coadunatm, Linn. Magnolias^ Juss. The lliicium Floridanum is a shrub, in gome instances entitled to be considered a small tree. Its leaves are scattered, or grow in tufts, on short petioles. They are evergreen, oval lanceolate, slightly acuminate, entire, smooth on both sides, and firm or flesliy. The flower buds proceed from the sides of the branches at the axils of the last year's leaves. The flowers grow on slender, nodding peduncles, an inch or two long. When fully expanded, they are about the size of a dollar, and of a dark, purplish crimson. Calyx deci- 78 ILLTCIUM FLORIDANUM, diious. Petals linear, obtuse, in three rows, about nine in a row, the uppermost row ascend- ing, the lowermost descending, and broader of more spatulate. Stamens thirty or more, diverg- ing, flat, depressed with the anthers recurved ; pollen white. Germs a dozen or more, round- ish-rhomboidal, compressed and arranged in a circular manner; styles short, recurved, pubescent on the inside. The fruit, which I have not seen, is represented by authors, as has been stated in the generic character. The leaves and young shoots of this species of Starry anise abound in a fine, clear mucilage, which becomes immediately perceptible in the mouth, if these parts are chewed, and which com- municates to water in a short time a ropy con- sistence. This mucilage is separated from the decoction by alcohol in the form of dark brown, tough, stringy coagiila. Muriate of tin causes a precipitate after these coagula are withdrawn, which seems to indicate the presence of extract. Sulphate of iron added to the decoction, coagu- lated the mucus and darkened the colour. I discovered no traces of resin in the portions submitted to experiment, and a strong tincture was not disturbed by water. The trial, howeverj was conducted on a small scale. STARRY ANISE. 7ff The bark and leaves of the lUieium Florida- num are strongly impregnated with a spicy, aromatic taste and smell, approaching that of the Magnolias and Liriodendron, but perhaps more similar to that of some of the pnngent seeds, particularly Anise and Coriander, between which they seem intermediate. This aroma is preserved in the distilled water, and fills the room with its fragrance, while distillation is going on. I was not able in my limited experiments to separate any volatile oil or camphor, on one of which principles, as in similar cases, the aroma doubtless depends. An account of this species of lUicium is given, with a figure, in the Philosophical trans- * actions for 1770, by John Eilis^v Esq. He says, "We are indebted for the discovery of this curious American tree to a servant of William Clifton, Esq. of West Florida, who was sent to collect specimens of all the rarer plants by his master ; and in April 176«'J», he met with it growing in a swamp near Pensacola. After this, in the latter end of January 1705, Mr. John Bartram, the king's botanist for the Floridas, discovered it on the banks of the river St. John, in East Florida, as appears from his description of it, and a draw- ing of a seed-vessel with some of the leaves, sent 80 iLLICIUai FLORIDAKUM. to Mr. Collinson." Mr. Bartrani's description of it, as it appears in his journal up the river fet. John, published by Dr. Stork, in his account of East Florida, is as follows. "Near here my son found a lovely, sweet tree, with leaves like the sweet bay, which smelled like Sassafras, and produces a strange kmd of seed-pop ; but all the seed was shed. The severe frost had not hurt it ; — some of them grow nearly twenty feet high, a charming bright evergreen aromatic.''* Of the medicinal properties of this shrub, I am unable to speak with the certainty, which might have attended an extensive number of trials, mhde with the bark of full grown specimens. From the evidence afforded by the bark and leaves of a o-reenhouse specimen, and by the analogy of other species, and similar trees, I {-hould not feel much hesitation in attributing to the lilicium the prop- erties of a tonic-stimulant and diaphoretic. 1 have at least satisfied myself that the bark of a twig, and three or four of the leaves, produce no un- pleasant consequence. Its bitter taste and aro- matic quality point out its analogy to Cascarilla, Canella, Sassafras, and other aromatic barks, which are regularly consumed in the shops. Its * It is very possible the above description may have been in- tended for lilicium parviflorum. STARRY ANISE. 81 co-species, the lllicium anisatum of the East, is used as a condiment to communicate an acjreeable flavour to certain dishes. The Chinese chew it after dinner as a stomachic and a SAveetener of the breath. In some parts of the East Indies the natives and Dutch mix it witli their tea and sherbet. It is also burnt as incense before their idols hy some of the oriental nations, and care- fully kept as an antidote to various poisons. The beauty of both these shrubs renders them desirable acquisitions to collectors of plants. BOTANICAL BEFERENCES. lllicium Floridanum, Link. — Curtis, Bot. Mag, L 439.' — Mi< CHAux, i. 526 — PuRSH, ii. 3S0. MEDICAL REFERENCES. Ellis, in Philosophical transactions abridged, xiii. Sr. f. 2. — SCHCETF, 91. PLATE XLVIII. Fig. 1. lllicium Floridanum. Fig. 2. Several stamens magnified. Fig. 3. Pistils magnified. Fig. 4. ti pistil separate. 11 AEISTOLOCHIA SEKPENTAEIA. Virginia Snakeroot PLATE XLIX.* J-T is probable tbat this root, like many other articles now used in medicine, was indebted to its sensible qualities, for its first introduction into use. As the name implies, its earliest medicinal character was founded on a supposed antidotal power against the bite of venomous serpents. Cornutus, at the end of his book on the plants of Canada, published at Paris in 163.^, tells us, that a root had been sent to him from " JSTotha Jlnglia,^^ which was called Serpentaria, and in the vernac- ular tongue Snagrdel. This root was a very sure safeguard against the bite of a huge serpent in that country, which proved inevitably fatal within twelve hours, unless a good portion of the antidote * I am indebted to a gentleman in Georgia for the very natural drawing of this plant. J'L.XLLY VIRGINIA SNAKEROOT. 83 was swallowed in season ; which being done, no one was ever known to be in danger of his life from this cause. The snagroel has had a great many rivals in the character of specifics against the bite of serpents. So great, indeed, is the number of articles which are called uniformly successful in sucli cases, that we are compelled to believe, that the bite of the rattle snake, and doubtless of other venomous serpents in the country, although attended with severe and alarming consequences, is nevertheless but seldom fatal ; and hence that the honor of proving specific in these cases is one of cheap acquisition. The Serpentaria grows in woods in the South- ern and Middle parts of the United States. It bears cultivation in any part of the union, though the most northerly situation, from which 1 have received wild specimens, is the vicinity of New Haven, from which place some living plants were sent to me by Dr. Monson. The genus Avistolochia has a monopclalous^ tuhuUir, crooked corolla^ swelling at base, and dilated at the border. Capsule inferior, sia^ celled^ The species Serpentaria has its leaves hearts shaped, oblong, acuminate ; stem Jlextioiis ; pe^ diincles radical. Pursh mentions a variety with 8% ARISTOLOCHIA SERPENTARIA. leaves so narrow, as to appear like a distinct species ; the flower, however, being not different. Woodville's figure of our plant has the leaves much too broad for the common habit of the vegetable. It belongs to the class Gynandria, order Hea^andria, or more properly Bodecandria, It is one of the few genera placed bj Linuseus in that class which are not of the Orchideous tribe. Natural orders Sarmentacece, Linn. AristolGchiWy Juss. This vegetable is humble in its growtli, being most commonly under a foot in height. The root is extremely fibrous, and sends up a number of stems. These are simple or slightly branched, jointed, flexuous, and often of a reddish tinge. The leaves are alternate, on sliort petioles, oblong, entire, acuminate, heart-shaped at base and three nerved. The flowers grow close to the ground, like those of Asarum. They have a stiff leathery texture, and a dull brownish purple colour. The peduncle which supports them has one or more leafets, and gradually enlarges into a furrowed obovate germ. The corolla, like others in this singular genus, consists of a long contorted tube, bent in the form of the letter S, swelling at its VIRGINIA SNAKEROOT. 85" two extremities, having its throat surrounded hy ail elevated edge or brim, and its border expanded into a broad irregular margin, forming an upper and under lip, which are closed in a triangular manner in the bud. The anthers are twelve in number, growing in pairs to the sides of the fleshy style, which is situated in the bottom of the corolla, and covered by a firm, spreading convoluted stigma, which extends over the an- thers. The capsule is obovate, six angled, six celled, with numerous small flat seeds. Snakeroot has a penetrating, rather agreea- ble, resinous smell, and a pungent bitter taste, resembling somewhat that of the Pinus Canaden- sis, or Hemlock spruce. It communicates its qualities both to spirit and water, but most to the former. 1 subjected a quantity of the root to distillation for one hour, and obtained in the re- ceiver a whitish pearly fluid, very strongly im- pregnated with the aroma, but less bitter than the root. On standing twenty four hours, this fluid deposited round the edges of the surface a considerable number of small white crystals, which proved to be pure camphor. They were inflammable, fusible with a sudden, and volatile with a gradual heat. I perceived no essential oil, though I)r. Lewis informs us, that if the 86 ARISTOIiOCHIA SERPENT ARIA. quantity of root, submitted to the operation, be large, there arises a small portion of pale coloured essential oil of a considerable smell but of no very strong taste. There is probably a portion of resin present, as I found that the root, after hav- ing been boiled in water an hour, still impregnated alcohol so as to cause a precipitate with water. The bitterness communicated to the infusion and decoction appears to reside in a variety of extrac- tive matter. Medicinally considered, Serpentaria is a tonic, diaphoretic, and in certain cases an antispasmodic and anodyne. It has been abundantly used in fevers of various descriptions, and has been com- mended by a host of medical writers. There is no doubt that it has been injudiciously employed in many cases, in fever attended with an active pulse and inflammatory diathesis. The early stages, also, of febrile diseases rarely admit the exhibition of so decided a stimulant, without injury. But in the advanced stages of fever and those attended with typhoidal symptoms, this medicine is resorted to with great advantage, both, alone and in combinaton with other tonics and stimulants. It is peculiarly useful in supporting the strength, and in allaying the irregular actions which attend great febrile debility, such as VIRGINIA SNAKEROOT. 87 subsnltus tendinum, delirium, watchfulness, ^c. Its bitter ingredients, and the camphor which it contains, no doubt contribute to these effects. It is most advantageously given in combination with bark, or with wine and opium. Snakeroot is a popular remedy in exanthema- tous disorders as a diaphoretic, being given to keep out the eruption, and to restore it when it has receded. In the latter case its use is doubt- less injudicious, and if it fails to reproduce the eruption, it greatly increases the heat, pain, and restlessness of the patient. It is better in cases where the eruption has receded to the disadvan- tage of the patient, to attempt its restoration by nauseating and saline diaphoretics, and even by a full emetic, than to incur the risk of aggravating the symptoms by a stimulating regimen. Dr. Chapman, in hi;^ Therapeutics, considers the Serpentaria as partaking the mixed qualities of a stimulant and tonic, and acting also as a diaphoretic and diuretic. It is peculiarly useful as an auxiliary to the bark. He states, that one .of the more early uses of the medicine was in the cure of intermittent fever. Whether alone it was found adequate to this purpose, does not clearly appear. "It was used by Sydenham in con- junction with wine, to prevent the recurrence of 88 ARISTOLOCHIA SERPENTARIA. the paroxysm, and from his account, not without advantage. As a general rule, he says, that in all cases, where it is expedient to combine wine with bark, the effect will be much increased by adding Serpentaria. The correctness of this observation has been fully confirmed by subse- quent experience, and it is now very much the practice to unite the two articles in the low states of disease." Dr. Chapman farther states, that though it is doubtful whether the Serpentaria, by itself, will cure ague and fever, it is certainly a powerful assistant to bark, not only in increasing its effi- cacy, but, v/hat is of great consequence, in enabling the stomach to retain the medicine. To remittent fever he thinks this medicine better adapted. It has here, in many cases, an indisputable superiority over bark, inasmuch as it is rarely offensive to the stomach, and may be given without injury, in those obscure states of the disease, where the remission is not readily tliscernible. He prefers, in these cases, a com- bination of bark, snakeroot, and soda. Snakeroot, he informs us, is much resorted to as a popular remedy in the management of the secondary stages of pleurisy. After bleeding, it is the ordinary practice, in many parts of our TiRGiNiA snak:eroot. 89 eountry, to resort to a strong infusion of this article with a view of exciting perspiration. Ca- tarrhs, rheumatisms, and other winter complaints, incident to rustic life, are managed in the same way. In that species of pleui'isy which is properly enough designated hy the epithet bilious, he has repeatedly had occasion to recur to the Serpen- taria, and always with more or less utility. This bilious pleurisy he considers as having all the characters of pneumonic inflammation, with the addition of some of the symptoms incident to au- tumnal fever, such as headach, great gastric dis- tress, and almost always violent vomitings of bile. It differs also from ordinary pleurisy in having less activity of inflammation, and consequently in not bearing the same extent of depletion. The sys- tem, indeed, will often be very evidently depressed by one or two bleedmgs. In this case the practice which has been commonly pursued is, after the removal of a comparatively small portion of blood, and the thorough evacuation of the alimentary canal ; to administer very freely draughts of the infusion of the Serpentaria in order to excite copious diaphoresis. Dr. Chapman concludes his remarks on this article, by stating, that it is admirably suited to check vomitings, and to tranquillize the stomach, 13 90 ARISTOLOCHIA SERPENTARIA. more particularly in bilious cases. It is given for this purpose in decoction, in the small dose of half an ounce or less at a time, and frequently repeated. The most common form of exhibiting snake- root is in infusion, for which purpose half an ounce may be steeped in a pint of boiling water for two hours, in a covered vessel. Of this in- fusion an ounce or two may be taken every three or four hours. Decoction is a less proper mode of preparing this plant, as it tends to dissipate the volatile parts, a portion of which is detained in a state of mixture by the infusion. Sometimes the powder is given in doses of from ten to thirty grains. A tincture of snakeroot is made by di- gesting an ounce of the root in a pound or some- what less of proof spirit. The compound tincture of bark, commonly called Huxham's tincture, contains Serpentaria as one of its ingredients. BOTANICAL REFERENCES. Aristolochia serpentaria, Linn. Sp. pi. — Walter, Flor. Car. 223. — WooDviLLE, ii. 291. t. 106. — ^Michaux, ii. 162. — Pursh, ii. 596. — Pistolochia sive Serpentaria Virginiana, &c. — Plukenet, t, 148./. 5.— Catesby, Car. i. 29. yiRGINIA SNAKEROOT. 91 MEDICAL REFERENCES. Murray, ^jpp. Med. i. 348. — Cullen, Mat. Med. ii. 85.— Chap= MAN, Therapeutics, ii. 411. — Lind. Hot climates, 104, 254. PLATE XLIX. Fig. 1. Jlristolochia serpentaria with the jloioer beginning t& expand. Fig. 2. /Slide view of the flower expanded. Fig. 3. Front of ditto. Fig. 4. Longitudinal section of the flower. Fig. 5. Style, anthers, and stigma magnified^ Fig. 6. Fruit. ALETEIS FAEINOSA. Star Grass. PLATE L. JL KNOW of no plant which surpasses the Alteris farinosa in genuine, intense and perma- nent bitterness. Neither aloes, gentian, nor quassia exceed it in the impression produced on the tongue. It has, on account of this property, attracted the observation of some medical men, and may hereafter become an article of more consequence in the Materia Medica. Although the number of trials, hitherto made, are perhaps not sufficient to fix with precision its exact char- acter, yet in a collection of American medicinal vegetables it ought not to pass unnoticed. This plant grows in most parts of the United States in fields and about the edges of woods, and flowers in June and July. I have found it near Boston on the south, but never to the north of it. JPI.Z.. jinjii.ii^:;-n /? frrY-^j y^/'/ rv //t^^ijry STAR GRASS, 93 Its mode of growth is not without beauty, the leaves spreading close to the ground in a radiated manner, like a star ; while the spike is supported by an almost naked stalk, at a distance above them. Tile names Star Grass and Blazing star are generally given to it in the country, from the peculiar appearance of its leaves. The genus Aletris has its corolla tiihiilar^ sice cleft, wrinkled, persistent ; stamens inserted into the base of the segments ; style triangular, separa- ble into three ; capsule opening at top, three celled, many seeded. The species farinosa, called alba by Michaux and Pursh, has its fiowers pedicelled, oblong-tubular, somewhat wrinkled in fruit ; the leaves broad lanceolate. Michaux observes that of the species referred by Linnseus to this genus, the A. farinosa is the only one which strictly belongs to it. Class Heocandria ; order Monogy- nia; natural orders Liliacew, Linn. Jlsphodeli, Juss. This plant has a single circle of radical leaves, which are sessile, nerved, lanceolate, and smooth. The stem or scape is from one to three feet high, invested with remote scales, which sometimes expand into small leaves. The flowers form a slender, scattered spike with Yevy short pedicels and minute bractes. Calvx none. Corolla white, 94/ ALETRIS FARINOSA. of an oblong bell-shape, divided at the mouth into six acute, spreading segments. The outside, particularly as the flower grows old, has a rough- is h, wrinkled or mealy appearance, by which the specific name was suggested. The stamens are short, inserted near the mouth of the corolla at the base of the segments. The circumstance of their being opposite to the segments, and not alternate with them, affords the most distinguish- ing mark of this genus. The anthers are some- what heart-shaped. Grerm pyramidal, half infe- rior, tapering : style triangular, separable into three. Capsule invested with the permanent corolla, triangular, three celled, three valved at top. Seeds numerous, minute, fixed to a central receptacle. The Metvis aiirea, of Michaux and Pursh, closely resembles this species, and it is difficult, by comparing specimens of the two, to point out any permanent distinctive marks. The leaves of A. aurea are somewhat narrower and the flowers bright yellow. Walter places it under A. farinosa as a variety, and adds that he could not detect a specific difference ; although the time of flowering and place of growth indicate that they are dis- tinct. In sensible properties they are similar. STAR GRASS. 95 In the London Philosophical transactions for 1730, a plant is mentioned by Clayton, which, though not described in botanical language, leaves little doubt that the Aletris farinosa is intended. He says, " there is another root of the species of hyacinths ; the leaves are grass-like, but smooth and stiff, of a willow-green colour, and spread like a star on the ground. From the middle shoots a tall, long, rush-like stem, without leaves, near two feet high ; on one side grow little white bell-flowers one above another. The root is black outwardly, but brown within. It is bitter and probably has the same virtues as Little Centaury. Some call it ague grass, others ague root^ others star grass.'^'' The root of the Aletris is highly resinous, and appears to contain a portion of extractive matter. The tincture, made by digesting the root in alcohol, is intensely bitter, and assumes a milky turbidness if water be added to it. The decoction is moderately bitter, and is not dis- turbed by alcohol. With chalybeate solutions it undergoes little change. The tincture is to be considered a stronger preparation than the de- coction, although the latter has a good share of the yii'tues of the plant. S)6 ALETRIS 1 ARINOSA. The bitterness of this vegetable has brought it into notice in the quality of a tonic and stomachic. I have been informed of its use for this purpose by physicians in diiferent parts of the country. The most common mode of its employment, I understand, is by infusion or decoction. Pursh speaks of it as a remedy in the colic, but on what principle it can operate in relieving that disease, I am at a loss to say.— The amount of bitter resin, which the plant contains, led me to suspect that it might possess some of the properties of aloes, to which the plant is botanically related ; but on trial, made in several instances with the root in powder, a dose of ten or twelve grains produced no effect of this kind whatever. A physician, who experimented with larger quantities, with a view to test this quality, informed me that a dose of twenty grains occa- sioned much nausea and tendency to vomit, followed by some dizziness ; but that no cathartic operation took place. Dr. Cutler, in his account of the plants of New England, informs us, that this plant has been considered useful in chronic rheumatism ; but does not mention the dose or preparation. As f\ir as we can sum up the testimony hith- erto offered respecting the general properties of STAR GRASS. 97 this plant, it appears that the infusion or decoction acts as a tonic in small doses. Indeed the exhi- bition of large ones would he inconvenient from the extreme bitterness of the plant. The powder, in small quantities, produces no immediate visible effect, except that it has appeared to invigorate the appetite. In large doses it disturbs the stomach, and possibly exerts some narcotic effect on the system. It remains to be determined whether these consequences are attributable to the resin, which the infusion does not dissolve ; or whether the largeness of the dose is alone instru- mental. It is well known that the stomach does not tolerate even gentian or any common bitter in large a dose. And it seems probable that if the Aletris should ever increase in reputation as a tonic bitter, it will only be by its use in limited quantities. BOTANICAL REFERENCES. Aletris farinosa, Linn. — Willd. iSp. pi. ii. 183.-~i?o^. Mag. t, 141 8.— Aletris alba, Michaux, Flora, i. 189. — Pursh, i. 225. — Hyacinthu« floridanus spicatus, Plukenet, amalth. 119, t. 437, /. 2; — Hyacynthus caiile nudo, &c,— -Gronov. Virg, 38, 13 98 AliETRIS FARINOSA. MEDICAL REFERENCES. Clayton, Phil. Trans, ahr. viii. 333. — Cutler, *imerican ^ead:. vol. i. 435. PLATE L. Fig. 1. Mefris farinosa. Fig. 2. Corolla opened to shew the insertion of the stamens. Fig. 3. Stamen magnified. Fig. 4. Fistil magnified. ^ ^/?Y>f/r^ r//-// r/i i/r/f /^i^r./YmM-'/M^ AMERICAN MEDICAL BOTANY, RHODODENDRON MAXIMUM. American 'Rose hay. PLATE LL XHE scenery of the American forest is dis- tinguished not less by the greatness of its natural features, the imposing and picturesque appearance of its mountains, its rocky precipices, its broad streams and lakes ; than it is by the magnificent clothing of wild shrubs and trees, the uncommon beauty of which, gives to rough and inaccessible spots a richness, that cultivation can hardly imi- tate. The Kalmia, described in our first volume, and the Rhododendron of the present article, which are reared with care and difficulty aa ornaments of European gardens and pleasure grounds, can be seen in perfection no where but in the uncultivated recesses of our own continent* lOS RHODODENDRON MAXIMUM. Near the summits of mountains, on the hanks of torrents and deep ravines, from which rivers take their rise, where the deep shade, moist soil and dashing water, preserve the atmosphere in a state of perpetual humidity ; these shrubs, in luxuriant size and vigour, are seen to eover tracts of great extent, at one season presenting an unbroken landscape of gorgeous flowers, and at another w ith their evergreen foliage forming an impene- trable shelter for the wild animals of the forest. Of the Rhododendron maximum, Mr. Pursli has designated three varieties. These are, 1. The Red, which inhabits swamps and the borders of mountain lakes from Canada to Caro- lina ; 2. The White, found in the swamps of New Jersey and Delaware ; 3. The Purple, on the highest mountains of Virginia and Carolina. This last variety is represented as peculiarly magnificent, growing to the size of a small tree, having its trunk eighteen inches and more in diameter, and its foliage triple the size of any other species. The first variety of this elegant shrub grows abundantly on the banks of Charles river, a dozen or fifteen miles from Boston. It even supports the winter as far north as the state of Maine, and was observed, by Dr. Eaton, growing plentifully AMERICAN ROSE BAY. 103 on the borders of Sebago lake near Portland. It does not bear transplantation well, but is apt to dwindle after the first or second year. It succeeds best when removed to a damp springy soil, and to a situation calculated to afford it shelter from the sun. The Shododendron, of the N^orthern states, is a large straggling shrub, very irregular in its mode of growth. The bark is of a greyish colour, very mucii cracked and broken. The leaves are in tufts at the ends of the branches. They ai*e evergreen, coriaceous, on round fleshy petioles, oblong-oval, entire, revolute at the edges, and pale underneath. Both leaves and petioles, when young, are covered with a light woolly substance. The flowers form a terminal cluster or thyrsus immediately above the leaves, the stalks and cal;yces of which are covered with a glutinous pubescence. Previous to its expansion, the w hole bunch forms a large compound bud, resemblino" a strobilus or cone, each individual flower-bud being covered by a rhomboidal bracte, which fails off when the flower expands. Calyx small, of five unequal obtuse segments > Corolla mo- nopetalous, funnel-shaped, with a short tube, the border divided into five large, unequal segments, which are white, shaded w ith lake, the upper and 104* RHODODENDRON MAXIMUM, largest, having a collection of orange coloured spots at its centre. Stamens declinate, unequal ; the filaments white, thickened and hairy at base , anthers two celled, opening by two pores at top ; pollen white. Germ ovate, hairy, glutinous ; style declinate, equal to the longest stamens, thickened upwards ; stigma a rough surface with five points. Capsule ovate, obtusely angular, five-celled. Seeds numerous, minute. Considered in its chemical character, this shrub is a resinous astringent. A decoction of the leaves gives strong proofs of the presence of tannin in large quantities. Both the bark and leaves, digested in alcohol, produce a resinous tincture, which is immediately rendered turbid by water. The glutinous covering of the flower stalks appears of a resinous nature. A decoction of the leaves in water affords nothing which is not soluble in alcohol, and did not alter by it in two days' standing. I have been induced to examine the Rhodo- dendron and to insert it in this work, on account of the reputation it has possessed of being poison- ous. The late Professor Barton, in his collec- tions towards an American Materia Medica, has given various intimations of this sort, the most conclusive of which is his expression, " This is AMERICAN ROSE BAY. 105 certainly a poison.'' — The result of my own attention to this shrub does not give reason for attaching to it suspicions of possessing a very deleterious nature. IN^one of its external charac- ters would lead to apprehensions of this sort, particularly the taste, which is simply astringent and herbaceous, and much like that of a common oak leaf. I know not what quantity might prove injurious, but under the conviction that the plant was not particularly dangerous, I have swallowed a green leaf of the middle size, so large that it required some resolution to masticate so unpala- table a morsel, but have found no ill effect what- ever to result from it. Medicinally considered, I think it must be ranked among the astringents, a place which both its sensible and chemical properties entitle it to hold. If it have any narcotic powers, they will probably be developed only by an extraordinary dose, which few persons will be likely to put to the test 106 RHODODENDRON MAXIMUM. BOTANICAL REFERENCES. Rhododendron maximum, Willd. Sp. pi. ii. 606. — Bot. Mag. t. 951. —Schmidt, Arb. t 121.— Pursh, i. 297.— Michaux, .A^. Jl. Sylva, t. 67. MEDICAL REFERENCE. B. S. Barton, Collections, i. 18. PLATE LI. Fig. 1. .4 branch of Rhododendron niaccimum in fiower and in bud. Fig. 2. Calyx and style. Fia;. 3. Stamen* YrrY/r^////rt' EUPHOEBIA IPECACUANHA. Ipecacuanha spurge. PLATE LIL JJ ROM the specific name given to this vege- table we infer, that befoi-e the true origin of the officinal ipecacuanha was known, this plant, among others, was for a time considered the source of that drug. The Pharmacopceia Danica was one of the works in which this reference was made, and Linnaeus undoubtedly paid some respect to the opinion in assigning the specific name. Nearly all the species of Euphorbia appear to possess the power of acting with violence on the stomach and alimentary canal. This power particularly resides in a milky juice which they exude on being wounded. Of the species which have been most extensively submitted to experi- ment are Euphorbia officinarum, esula, heliosco- 15 108 EUPHORBIA IPECACUANHA. pia, dalcis, peplus, exigua, Cyparissias, palustris, and Cliaracias. Professor Murray has collected details respecting the operation of most of these, from various medical authorities. It appears that they all excite vomiting or purging, and in large doses hring on violent burning pains of the stomach and bowels, heat and thirst, followed by great prostration of strength, cold sweats, and in some instance, death. In small quantities, how- ever, they have been used as medicines with safety, although some of them are uncertain in regard to their dose, and difficult to manage in their operation. [JVofe B.] The genus Euphorbia comprises a vast num- ber of species, of different habit, size and mode of growth. The flowers are frequently minute, very complex, and difficult of examination. They have a calyciform involiicriim with four or Jive segments like petals, and the same niimher of interior segments like nectaries. Stamens twelve or more. Filaments articulated. Fertile fower solitary, stipitate, naked. Styles three, hifid. Capsule three seedet?.— The species Ipecacuanha is procumhent, with opposite, ohovate, ohlong or linear leaves ; peduncles axillary, one flowered, elongated. IPECACUANHA SPURGE. 109 The genus was placed by Linnaeus in the class Bodecandria, order Trigynia, Michaux, considering as separate male flowers, the bodies of stamens which correspond, in number, to the nectaries or lacinulse, has referred the genus ta Monwcia, Monadelphia. In this he has been followed by various American botanists.— In natural arrangements this genus is among the Tricoccas of Linn, and Eiiphorbice of Juss. The Euphorbia ipecacuanha is a low, tufted plant, growing in sandy soils in the Middle and Southern states. Michaux remarks, that the plants are sometimes buried in the sand. It is a polymorphous vegetable both in its shape and colour, the leaves continually differing in their outline, even in contiguous plants ; and the colour varying from green to crimson. The root is irregular and fleshy, very large in proportion to the plant it bears, running deep into the sand, sometimes, as Mr. Pursh informs us, extending to the depth of six feet. The stems, from one root, are numerous, erect or procumbent, forming large bunches on the surface of the ground. They are smooth, regu- larly dichotomous, and jointed at the forks. The leaves are inserted at the joints, opposite, sessile, smooth, having most frequently an oblong shape 110 EUPHORBIA IPECACUANHA. though different plants possess every intermediate variety in the form of the leaf, from circular to linear. Their size and colour are likewise vari- able. The flowers are solitary on long peduncles from the forks of the stem. Calyx spreading, divided into five obtuse segments. Inner seg- ments or nectaries five, small, gibbous. Stamens numerous, in five parcels, appearing, at different times, two or three together, with double anthers. The fertile flowers have a large, roundish, droop- ing, pedicelled germ, crowned with six revolute stigmas. Capsule three celled. T!ie dried root of the Euphorbia ipecacuanha is of a greyish colour outside, and white within. It is light and brittle and has about the hardness of cork. To the taste it is sweetish and not particularly unpleasant. I subjected some portions of the root to chemical examination and obtained the following results. — Sulphuric ether digested on the pow- dered root dissolves a part of it ; and this ethereal solution gives a precipitate, if alcohol is added to it. — Alcohol alone takes up another portion of the root, and assumes a pearly turbidness after water is added. Both the ethereal and alcoholic solu- tions, evaporated to dryness, leave a residuum which is fusible and inflammable. The decoction. IPECACUANHA SPURGE. HI gives no precipitate with gelatin or sulphate of iron. With alcohol it gave out a white precipi- tate which rendered the solution turbid, and subsided in flocks. The cold infusion exhibited the same phenomena in a smaller degree. From these appearances we may infer that the root contains caoutchouc, resin, mucus and probably fsBcula. The Euphorbia ipecacuanha has long been known to possess the same property, which is so frequent in its genus, of exciting the stomach powerfully as an emetic. The appropriation of its specific name seems even to imply that such a property had been recognised in this species in a more eminent degree, than in the rest. It does not appear, however, tliat it has ever con- tinued long in use, this being prevented, proba- bly, by the suspicious character of the race of plants to which it belongs. The late Dr. Barton mentions this vegetable among his indigenous emetics, but considers it too violent and uncer- tain to be depended on as a safe medicine. Within a few years the plant has been attended to by some medical gentlemen in Philadelphia, who report more favourably of its powers and mode of operation ; and consider it as a safe, certain and manageable emetic, applica- lis EUPHORBIA IPECACUANHA. ble to most of the cases in which medicines of this kind are called for. Being desirous to obtain personal knowledge of the medicinal character of this vegetable, I instituted trials with different parcels of the dried root, some of which were gathered by myself, in flower, near Philadelphia, and the rest sent me by friends from Baltimore and Washington. Portions of these roots were given to a variety of patients in the Dispensary and Almshouse by myself and by other physicians, who have obliged me by communicating the results of their obser- vations. These experiments have led to the conclusion that the Euphorbia ipecacuanha in doses of from ten to twenty grains is both aa emetic and cathartic ; that it is more active than ipecacuanha in proportion to the number of grains administered ; that in small doses it operates with as much ease as most emetics, in a majority of instances. If it fails, however, at first, it is not so safely repeated as the other emetics in com- mon use. Given in large doses it excites active and long continued vomiting, attended with a sense of heat, vertigo, indistinct vision, and prostration of strength. I have not ventured upon any large dose myself, but have been informed, that such is the effect^ by those who have given the root in IPECACUANHA SPURGE. 113 doses of two scruples and upwards. The plant appears to differ from the South American Ipe- cacuanha in having the degree of its operation proportionate to the quantity taken ; the process of vomiting not being checked by the powder being thrown off of the stomachj as frequently happens, when common Ipecac is given in large doses. At my request. Dr. James McKeen made this plant and another species, E. corollata, the sub- jects of an inaugural dissertation at Harvard University, in 1830. As his observations have been made with some care, and illustrate very fairly the action of the medicine, I insert the principal cases from his manuscript. " Case I. The first experiment," he observes, " made with this species of the Euphorbia was upon a man of intemperate habits, about twenty seven years of age, and who appeared to be a candidate for Delirium Tremens. I gave him ten grains. He told me that it always required powerful doses of medicine to produce any effects upon his stomach or bowels, but as I was then a stranger to the powers of the Euphorbia ipecacu- anha, it was thought prudent not to hazard a large quantity until something had been ascer- tained of its strength. ¥» lien I called in the 114^^ EUPHORBIA IPECACUANHA. morning after it was taken, I learned that the medicine had produced a gentle purging, pre- ceded by a considerable degree of nausea, but that there had been no vomiting. " Case II. The next fair opportunity which occurred for experiment was in the case of a female about thirty seven years of age. This woman, for a considerable portion of her life, had suffered from syphilis ; nothing remained now, however, specifically of this kind, excepting the marked effects of a constitution shattered by disease. I gave her at first ten grains of the Euphorbia ipecacuanha, and in twenty minutes, no signs of vomiting occurring, I gave her eight grains more, and kept adding to the quantity, which she had taken, until it amounted in the whole to forty grains. I remained by this patient until vomiting commenced, which was precisely thirty five minutes after the exhibition of the first ten grains. As the influence of the mind, in contemplating the effects of an emetic, will often induce its more speedy operation, I diverted the patient's attention as much as possible, that no consequences might ensue, but such as were produced by the specific action of the medicine. As soon as I ascertained that this Euphorbia- ipecacuanha was likely to produce effectual IPECACUANHA SPURGE, H.^ Vomiting, I left the house. About thirty hours afterwards I called to see tliis patient, and with much surprise found that the quantity I had given her had continued to operate by emesis and catharsis ever since. She was, however, very little exhausted, and there was nothing of cramp either on the stomach or extremities which so often distress those who are too severely vomited. About this time there was a cessation of vomiting without the assistance of remedies. Two days afterwards this woman told me she had not been as well as she then was for a number of years. The powerful vomiting produced a considerable degree of dizziness, but this went off in the course of twenty four hours. I had quite despaired of vomiting this patient with tlie Euphorbia ipecacuanha. In no instance after- wards was this medicine more than half as long in producing vomiting as it was in this case. Case III. A gu4 of about eighteen years of age, whose manner of living was similar to that of the person mentioned in the preceding case, applied to me for an emetic ; I gave her thirty grains of the Euphorbia ipecacuanha, and told her to take half of this quantity, and if it did not operate in half an hour, she might take the re- mainder. Contrary to my injunctions she took 16 116 EUPHORBIA IPECACUANHA. the whole at a single draught. In fifteen minutes her attendants told me she began to vomit, and continued to throw up, at intervals, smartly for five hours, and was purged seven or eight hours more. For some time after this she complained much of dizziness. Case IV. As I had found, in the first trial, that ten grains of the Euphorbia ipecacuanha failed to produce vomiting, I tried the same dose upon another subject, which was a woman of about forty eight years of age, to determine if so small a quantity would produce vomiting. In about fifteen or twenty minutes after the medicine was received into the stomach, it began to operate. After she had vomited three times, it commenced purging, and produced three or four evacuations. This woman did not complain of any dizziness, as those did in the two preced- ing cases. Case V. A woman about thirty one years of age took fifteen grains of the Euphorbia ipecacu- anha ; in seventeen minutes it began to operate, and vomited the patient every few minutes, until the operation amounted to five or six times, and afterwards a moderate purging ensued. The operation, in this case, was more satisfactory than any preceding ones, as it effectually evacuated IPECACUANHA SPURGE. 117 the stomach and bowels, without a too long con- tinuance of the vomiting'. Case YI. A man of forty years of age was seized with symptoms of fever. Four grains ctf sulphate of copper and twelve of common ipecac were given. This dose produced no emetic operation, but occasioned violent purging. Forty eight hours after, I gave him twenty grains of Euphorbia ipecacuanha, in powder, which pro- duced very effectual evacuations from the stomach, vomiting him eight or nine times ; after which he had one or two alvine discharges. Case VII. In one instance, for experiment, I gave four grains of this plant j but it neither affected the stomach nor bowels, nor the feelings of the patient, nor his pulse." From what is now known respecting the Euphorbia ipecacuanha, we are justified in con- sidering it an active emetic, and, if prudently administered, more safe than a majority of the species of its genus. It wants, however, the peculiar mildness of the officinal Ipecacuanha, which, in cases of slow operation, permits the dose to be accumulated by repetition, until its due effect takes place, without danger of excessive violence in the length and degree of evacuation, and without an injurious impression on the 118 EUPHORBIA IPECACUANHA, nervous system. This, indeed, appears to be the common defect of the active North American emetics hitherto examined. And until a more exteusive examination has brought to light new substances of this class, or better defined the modes of preparation and use of those already known, we cannot wish that the South American drug should be diminished in our markets, or less familiar to our physicians. BOTANICAL REFERENCES. Euphorbia Ipecacuanha, Linn. Sp. pi. — Willd. ii. 900.— Mi- CHAux, Flora, ii. 212. — Pursh, ii. 606. — Botanical Magazine, t, 1494. — Euphorbia inermis, &c. — Gronovius, Virg. 74. — Tithymalus flore minimo herbaceo ? — Clayton, Phil, trans, abr. viii. 331. MEDICAL REFERENCES. ScH«EPF, Mat. Med. 74.— B. S. Barton, Coll. 26 W. P. C^ Barton, Teg. Mat. Med. vol. i. PLATE LII. Fig. 1. Euphorbia Ipecacuanha. Fig. 2, 5, 4, 5. Different forms and sizes of tfie leaf observed in individuals of this species. Fig. 6. Red variety of the leaves. Fig. 7. Calyx. Fig. 8. Calyoe opened, with five of the stamens expanded} Fig. 9. Ji perfect flower. Tig. 10. Styles and stigmas magnified'. J*I, JJJf (:'/^A//-^z^i-a e^ny/^xAz ulnnin kSmUA- EUPHORBIA COROLLATA. Large jlowering spurge. PLATE LIIL Jln point of stature and the siiewy appear- ance of its flowers, this species of Euphorbia differs eminently from that described in the last article. In the common features, however, of the genus, such as its lactescence, its taste, and its medicinal powers j the consanguinity of the two plants evidently appears. I am not aware that this species has been much known for its operative qualities, until within a very recent period. The indians were, indeed, acquainted with the medicinal properties of more than one species of Euphorbia. They doubtless made use of the E. ipecacuanha, and not impossibly of the present species also. In Mr. Clayton's letter to Dr. Grew, contained in the Transactions of the Royal society for 1730; and which we have noticed 1^0 EUPHORBIA COROLLATA. in speaking of Aletris farinosa, the writer states, that the Aborigines made use of " the roots of Tjthymal, of which there are two sorts, the one Jlore minimo herbaceo, the other floi^e albo. The flower of this last," he says, " is small, but large in comparison with the other. They are repenteSf and grow in old manured grounds. They chiefly make use of the latter of these, and it is a most excellent purge, though it sometimes vomits. It is quick but moderate in its effect, and has this pe- culiarity, that it opens the body, when other more violent purgatives will not move it." We might safely conclude that the white flowering species, here noticed, is the Euphorbia corollata, were it not for the term repentes applied to both plants. It is not improbable that in this respect, the writer might have been misinformed. Pursh informs us that Euphorbia corollata grows in dry fields from Canada to Carolina. 1/ have never met with it north of Pennsylvania. The drawing which illustrates our description is from a specimen cultivated in the Botanic garden at Cambridge. It is a tall, erect plant, from one to five feet in height, resembling, at a dis- tance, some of the white flowering corymbiferw. It begins to flower in June, but is not fully ex- panded until July or August. Its specific LARGE FLO\YERIN& SPURGE. IM character is as follows. Umbel jive rayed, three parted, dichotomous ; leaves and involucra oblong, obtuse; segments of the ealycc obovate, petaloidy coloured. The shape of the leaves is subject to variety, as is also their smoothness or hairiness. This plant has a large branching root which sends up a number of stems, frequently from two to five feet in height. They are erect, round and in most instances simple. The leaves are scattered, sessile ; oblong, obovate or linear, a little revolute at the margin, smooth in some plants, very hairy in others. The stem divides at top into a large five rayed umbel, supported by an involucrum of as many leaves. Not unfre- quently a small axillary branch or two arise from the sides of the stem below the umbel. The rays of the umbel are repeatedly trifid or dicho- tomous, each fork being attended by two leafets and a flower. The top of the stem or centre of the umbel is turgid, and often bears a precocious flower. The calyx is large, rotate, white, with five obtuse petal-like segments, from which the name of the species has been taken. The nec- taj'ies or inner segments are five, very small, obtuse projections situated at the base of the segments. Stamens a dozen or more emerging two or three at a time, with double anthers. 13S EUPHORBIA COROIiLATA. Germ pedicelled. Capsule three celled. A great portion of the plants are wholly stamini- ferous. The results of a short chemical examination of this plant were very similar to those afforded by E. ipecacuanha. The ethereal solution was made turbed by alcohol, and the alcoholic by water. The precipitate in the last instance seemed denser and more abundant than it was in the former species. The decoction deposited a mucus or feculent substance, by means of alco- hol, as in the other plant. The same sweetish taste characterised the solutions of both veg- etables. It has been observed, by late experimenters in vegetable chemistry, that most of the lactes- cent or milky plants contain caoutchouc. That they contain a substance of this nature, which is dissolved by ether and not by alcohol, I am able to attest from the examination of various lactes- cent plants inserted in this work, and some others. The properties of Euphorbia coroUata have been lately brought into notice by W. Zollic- koffer, M. D. of Baltimore, to whom I was first indebted for my specimens of the root and living plant ; and who has furnished me with a vai'iety LARGE FLOWERING SPURGE. 123 of facts relating to its properties. Dr. Z. states that this plant is fjuite common in some parts of the state of Virginia. In some districts of Mary- land, and more particularly in Anne Arundel county, it grows in the greatest abundance, where it is recognised hj the common appellations of Milkweed, Snake's milk, Ipecacuanha and Indian. Physic. It delights in a poor, dry, and sandy soil. It is seldom or never found growing in the woods, hut in fields that are cultivated every two or three years. The farmers have frequently told him that it is very hurtful to small grain, >vhen it grows in great quantities, and the com- mon means that are made use of, such as plough- ing and harrowing, in order to kill bluegrass^ have the effect of increasing the quantity and rapid growth of this plant. It is never eaten by animals. The root is sometimes used as an emetic by the country people ; and it is esteemed in the cure of dropsy. The stalks, which arise from the common trunk of the root, are some- times as many as thirty, and from this down to a single one. The largest roots, which he recol- lects seeing, measured from an inch to two inches and a half in circumference. He has been in the habit of using the Euphorbia corol- lata, for some time past in practice, as an emetic^ 17 134} EUPHORBIA COROLLATA. ill the place of the Ipecacuanha of the shops ^ and thinks it in no respect inferior to this article. Combined with opium and the Sulph. potassse in the proportions of the Pulv. doveri, he has found it to be a valuable diaphoretic. The con- tused root, in its recent state, will excite inflam- mation and vesication, when applied to any part of the body ; which generally goes oif in the course of four or five days whithout being attended with any inconvenience whatever. He was led to give it a number of trials in this way from the circumstance of his face becoming considerably inflamed after having iiandled large quantities of the root. As an expectorant, this plant, he says, is deserving of the attention of practitioners. Dr. Z. has furnished me with minutes of seventeen cases, in which he administered the powdered root of this plant in doses of fi'om ten to twenty grains. In all of these it operated by vomiting, with the exception of two cases, where it produced nausea, followed by catharsis. Hav- ing tried a variety of preparations, he states, that the extract may be given in doses of from five to eight grains ; the wine prepared in the same way as Vinum ipecacuanha, in dose of an ounce or an ounce and an half. Of the root in powder from fifteen to twenty grains was found a proper LARGE FLOWERING SPURGE. 1^5 emetic. He considers this medicine as liaving' a peculiar advantage in possessing no unpleasant taste ; being only followed by a sense of heat in a few minutes after it is taken. But this is by no means lasting, nor does it produce any material uneasiness. In some experiments, to determine the solu- ble portions of this root, Dr. Z. found that two thousand one hundred and sixty grains of the recent root afforded one hundred and two grains of watery extract ; and a like quantity by diges- tion in alcohol gave one hundred and twenty three grains of alcoholic extract. He did not observe any difference in the activity of these two extracts. Dr. McKeen, v*^hose Dissertation on the species of Euphorbia has been already cited in the last article, has detailed the circumstances of twelve cases, in which he administered the Euphorbia coroUata. His experiments differ from those of Dr. Zollickoffer, in the quantity of the root used, being always smaller. The doses, which he gave, were from three to twelve grains of the powder. In every instance the medicine operated as a cathartic. In most of the cases nausea was produced, but in three only, out of the whole number, it was followed by vomitings 4^6 EUPHORBIA COROLLATA. In one case a dose of three grains proved actively cathartic in four hours. In another five grains produced vomiting. In a third no effect was experienced from twelve grains, except that of a moderate laxative. In one instance twenty grains "v^ere given, which produced vomiting three times, followed by about twenty alvine evacuations. I have placed portions of this plant in the hands of several practitioners and medical stu- dents, with a request to be informed of the effect, when suitable opportunities for its exhibition had occurred. In a majority of the instances I have been told, that a cathartic operation had followed its use ; and sometimes, though less frequently, an emetic. It rarely has proved inactive. The Euphorbia corollata must undoubtedly be ranked among the more efficient medicines of the evacuating class. Dr. McKeen concludes, from his experiments, that it is a very certain purgative, possessing, he thinks, about double the strength of jalap. It exerts its cathartic efficacy in doses of less than ten grains. If given to the amount of fifteen or twenty grains, it is very sure to prove emetic ; the proportion of its failures, being not greater than occurs in the use of other emetic medicines. The only inconven- iences which have come to my knowledge, as liARGE FLOWERING SPURGE. 127 attending it, are, that if given in small doses, for a purgative, it is apt to produce nausea ; while in the large doses suitable for an emetic, it some- times has induced a degree of hypercatharsis. But it must he observed, that many of the medi- cines, in common use, may occasion similar consequences in jtersons of peculiar habit and irritable fibre. Future experiment will, no dc«ubt, determine whether the Euphorbia corollata is any more irregular and unmanageable than other medicines of its kind, or whether it is entitled to a permanent and useful place in the Materia Medica. Many, and perhaps all the species of Euphor- bia are powerful external stimulants. Sover.J are used as a sort of caustic to destroy warts. The gum, called Euphorbium, produced by the Euphorbia officinarum, is a strong vesicatory, employed by farriers, and sometimes used to adulterate the plaister of Cantharides. The blistering power of E. corollata has been stated by Dr. Zollickoffer. This active genus of plants deserves a thorough investigation with a view to this particular property, to determine whether they are safe and manageable vesications, or virulent and uncertain. 138 EUPHORBIA COROLLATA* BOTANICAL REFERENCES. Euphorbia corollata, Linn. — Willd. ii. 916.— Michaux, ii. 210ir — PuRSH, ii. 607. — Tithymalus marianus, &c. — Plukenet, Mant. 182. t. 446./. 2. MEDICAL REFERENCES. Clayton, Philosophical transactions abridged, viii. SSL — Zol- EiCKOFFER, Materia Medica. Baltimore, 1819. PLATE LIII. Fig. 1. Euphorbia corollata, the top of a plant raiJier below ilv& common size. Fig. 2. Barren fioiver. Fig. 3. Calyx not fully expanded. Fig. 4. Stamen. Fig. 5. Fertile flower. 6 7 ^n^in iJmM^ POLYGALA RUBELLA. Bitter Poly gala. FLATE LIV. A HIS plant is interesting from the curious manner in which a part of the fruit is produced, hy a kind of imperfect flower growing close to, and in some instances under, the surface of the ground. It is not the only species of the Polygala which has this peculiarity. I have often observed little shoots at the root of P. paucifolia, one of the most beautiful of the genvis, bearing apterous flowers and subterranean fruit, precisely like those represented in our plate. The P. polygama. of Waller and Pursh, if, indeed, it is a distinct species, has the same remarkable mode of growth. It is difficult to imagine what end is attained by nature in tiiis singular arrangement, by whicli a part of the seeds are ripened in the sun, wiiile the rest, like the fruit of Arachis hypogsea, is 130 POLYGAIiA RUBELLA. buried from the light. To the eye there is no difference between seeds taken from the upper or lower racemes of the plant. It would be Avorth while to ascertain if the two will vegetate equally well. The genus is marked by a calya^ ^ffi'^^ leaves, two of which are wing-like and coloured. Capsule obcordate, two celled and two valved. The spe- cies rubella has its stems simple ; leaves linear- ohlong, mucronated ; flowers racemed, those of the stem tvinged, those of the root apterous. Class Biadelphia, order Octandria; natural orders Lomentacew, Linn. Pediciilares, Juss. The Poly gala rubella, here described, is the plant designated by that name in Muhlenberg's catalogue, as £ have formerly learnt from the author himself. There is little doubt that Willde- now's plant is the same, described from an imperfect specimen. It is found in dry, sandy, or gravelly soils in many parts of the United States, and flowers in June and July. Eoot somewhat fusiform, perennial, branch- ing. Stems numerous, ascending, smooth, angu- lar, simple. Leaves scattered, smooth, the lower ones obovate, smaller; the upper ones linear- lanceolate, obtuse, mucronated, sessile. Flowers purple, short-crested, in terminal racemes. BITTER POLY GALA. 131 Bractes small, ovate-lanceolate, caducous. Wings of the calyx rhomboid-oval, obtuse, with a slight middle nerve. Corolla small, closed, of three segments, the middle one largest and crested by the division of its sides and extremity. Anthers eipht, forming a double row, the filaments coa- lescing. Germ compressed, inversely heart- shaped ; style deflexed ; stigma bearded inside, with a prominence below it. Capsule inversely heart-shaped, nearly smooth, margined, and in- vested with the wings of the calyx. Seeds two, obovate, hairy, with a transparent appendage or strophiole on the inside. From the base of the stems proceed a number of prostrate shoots situated upon, and sometimes nearly under the ground, bearing a row of incomplete fertile flowers. These flowers are furnished with a calyx without wings, a minute corolla and stamens, and a short style. The germ and fruit precisely resemble those of the more perfect flowers. Like some of the European species which it resembles in habit, this plant is a strong and permanent bitter, imparting its sensible proper- ties both to spirit and to water. I digested a portion of the dried plant in ether, and added alcohol to the solution. No change was visible at the time of mixture, but on standing till the 18 133 FOLYGALA RUBELLA. ether had partly evaporated, the alcohol became turbid. A tincture of the plant was not imme- diately affected by adding water, but on standing oyer night it became very turbid, and in a few days deposited a large precipitate. The bitter- ness, which is probably of the extractive kind, was communicated to cold, as well as hot water ; and to alcohol. The aqueous solutions appear strong enough to represent the virtues of this vegetable. The Polygala rubella, from its extreme bit- terness, has attracted the notice of various medical practitioners in the Northern states. I have been assured by those who have tried its efficacy, that the infusion administered in small doses, proves a useful tonic and stimulant to the digestive organs. In large doses it opens the body and excites diaphoresis. Its powers appear to resemble those of Polygala vulgaris and P. amara of Europe, to which it has a close botanical resemblance ; and which have enjoyed a certain degree of medicinal reputation as tonics and expectorants. BITTER POLYGALA. 133 BOTANICAL REFERENCES. Polygala rubella, Muhlenberg, Catal. — Willd. iii. 875. PuRSH, ii. 464. — Polygala polygama ? — ^Nuttall, genera, ii, 87. PLATE LIV. Fig. 1. Polygala rubella. Fig. 2. d flower. Fig. 3. Calyx, Fig. 4. Corolla magnified. Fig. 5. Fruit of ditto. Fig. 6. Body of stamens^ Fig. 7. Pistil NYMPHiEA ODORATA, Sweet scented Water lily. PLATE LV. Ihe common Water lily, of Korth America, tery much resembles that of Europe iu its external form, but differs remarkably in the fine fragrance of its flowers, those of the old continent being nearly destitute of odour. It belongs to a very beautiful tribe of aquatic plants, a great part of which are natives of the torrid zone. Those species which support the cold of our northern latitudes, are enabled to do so only by the depth of water, under which it is their habit to vegetate. Xature has provided a sort of spon- taneous hotbed for these plants, by placing then* roots at such a depth from the surface of the element in which they grow, that the frost, which would otherwise prove fatal, does not reach them at the coldest season. SWEET SCENTED WATER LILY. 135 The Nympbsea odorata, the finest of the iiorthern species, grows abundantly in most parts of the United States, about the edges of rivers and ponds, where the water is more than a foot in depth. It is one of the largest of our native flowers, and though it has often been represented as inferior, in size, to the water lilj of Europe, I am sure that this comparison can only have resulted from the inspection of culti- vated specimens. The annexed drawing was made from a full grown and fully expanded specimen, and is actually smaller than the flower from which it was taken. Every angler is familiar with the leaves and stems of this plant, which, with a few similar aquatics, forms floating beds about the edges of deep fresh waters, affording to the fish a favourite shelter from the light ; and often rendering them Biore essential service, by entangling the hooks and lines of their pursuers. The roots of this plant creep through the muddy bottoms of ponds to a great extent. They are very rough, knotted, blackish, and as large as a man's arm. The porous stalks, which proceed from these, ai'e bouyed up by the quantity of air they contain, and continue to be elongated till they reach the surface of the water, which is 136 NYMPHiEA OD GRATA, often at the height of several feet. The upper side of the leaves has a highly repelleut power for water, owing to its finely polished surface, from which the fluid rolls off as from a coating of oil. When the buds have attained to maturity, they emerge and expand their flowers. This takes place in the morning ; and when the sun is bright, a bed of these flowers presents a truly magnifi- cent spectacle. Owing to the concavity of the calyx and petals they continue to float during a great part of the day. They are seldom elevated from the surface, except when the stem is un- commonly large, or pushed upward by some displacement of the adjacent leaves. At night, or before, the flowers close, and either rest on the surface or sink beneath it till the subsequent day. When flowering is over, the germ sinks to the bottom and there ripens its fruit. The genus IVymphsea is now separated from some other plants formerly attached to it by the following character. Calycc four or five leaved ; petals many, inserted into the germ below the stamens ; stigma radiated, sessile with a tubercle in the middle ; berry many celled, many seeded. This species very nearly resembles the JV*. Alba of Europe, but appears distinct by the following marks. Leaves orbicular-cordate, entire^ the lobes SWEET SCENTED WATER LILY. 137 acuminate, and veins prominent beneath ; catyx four-leaved, equal to the petals. — Linnseus placed this genus in his Miscellanew, and Jussieu with the Hydro charides. The stalks, both of the leaves and flowers, spring directly from the root. They vary in length from one foot to five or six, according to the depth of the water. The petioles are some- what semicircular, the scapes round. Both are perforated throughout by long tubes or air-vessels which serve to float them. The leaves, which swim on the surface, are nearly round with a cleft or sinus extending to the centre, at which the petiole is inserted in a peltate manner. The lobes on each side of this sinus are prolonged into an acute point. The upper surface is of a bright glossy green almost without veins ; the lower surface is reddish and marked by a multi- tude of strong prominent veins diverging from the centre. The calyx has four lanceolate leaves, green without and white within. Petals nume- rous, lanceolate, of a delicate whiteness, with sometimes a tinge of lake on the outside. Sta- mens numerous, yellow, in several rows ; the filaments dilated, especially the outer ones, so as to resemble petals ; the anthers in two longitu- dinal cells growing to the filaments and opening 138 KYMPH^A OD GRATA. inwardly. The stigma has from twelve to twent j four rajs, very much resembling abortive anthers, at first incurved, afterwards spreading. At the centre is a solid hemispherical protuberance, usually called a nectary, but which appears to me more like the true stigma. The roots of this plant are among the strong* est astringents, and we have scarcely any native vegetable which affords more decided evidence of this property. When fresh, if chewed in the mouth, they are extremely styptic and bitter. Their decoction instantly strikes a jet black colour with sulphate of iron, and yields a dense, white precipitate to a solution of gelatin. With alcohol it deposites a slight flocculent substance resem- bling fsecula. Tannin and gallic acid in large quantities are to be considered its most character- istic ingredients. The flowers have a delicious odour, hardly surpassed by any perfume which the summer produces. This fragrance is perfect only when the flowers are fresh, and, as they droop, becomes contaminated with the common smell of aquatic plants. It is peculiar in its character, and resembles that of no other plant with which I am acquainted. I have several times attempted to separate this perfume by distillation both with SWEET SCENTED WATER LILY, 139 water and spirit, but have never succeeded in preserving it in the faintest degree. It is much more fugacious than the perfume of roses, and seems to be destroyed by the application of heat. Possibly the employment of a large quantity of flowers at a time might yield a better product. The stamens appear more odorous than the petals, or at least preserve their odour longer in drying. The roots of the water lily are kept by most of our apothecaries, and are much used by the common people in the composition of poultices. They are, no doubt, often injudiciously applied to suppurating tumours, since their astringency must be rather discutient, than promotive of suppuration. They are occasionally used by physicians in cases where astringent applications are called for, and answer a purpose somewhat analogous to that of lead poultices and alum curds. The roots, which, when fresh, are large and fleshy ; in drying, lose a great part of their weight and size, becoming spongy and friable. The Mymphsea alba of Europe, which appears perfectly similar in its qualities to the American plant, was celebrated by the ancients, [^J^ote C] as an antaphrodisiac, and as a remedy in dysen- tery and some other morbid discharges. To the 11) 140 NYMPHJBA OD GRATA. latter purpose its astringency might, in same instances, make it well suited. The roots and seeds of the Nymphsea lotus were^ used by the ancient Egyptians as bread. BOTANICAL REFERENCES. Njmphsea odorata, WiLLD. Bot. Bepository, 297. — Pursh, ii. 368. — Nympheea alba, Michaux, i. 311. — Walter, ClaroL 155. Castalia pudica, Salisbury, dnnah of BoU ii. 71. MEDICAL REFERENCE. Cutler, Amer, Transactions, i. 456. PLATE LV. Fig. 1. Leaf and jloiver of J\'ymp}icea odorata. Fig. 2. Different stamens from the same fiower. Fig. 3. Stigma. Fig. 4. Section of the germ. Fig. 5. *9 cell of the germ magnified. Fig. 6. Section of the scape. Fig. 7. Section of petiole. '^ /'^Y//.^///aVit^ 1/ /?(9J PEINOS VERTICILLATUS. Black Alder. TLATE LVI, After tlie leaves have fallen in autumn, this shrub becomes conspicuous by its glossy scarlet berries, v^hich adhere in bunches, for a long time, to the sides of the branches. Of the objects which impart any liveliness to this season of decay, the most noticeable are those which change the hue of their leaves from green to red, as the oaks, the vaccinia, ^c. those which flower late, as the Hamamelis, and those whose fruit attains to maturity under the influence of frost, and appears fresh and vegetating, while other things are withering about them. The species of Prinos are of the last description. This genus consists of shrubs, a part of which are deciduous, and a part evergreen ; bearing sin.all lateral or axillary flowers. It is nearly 14^ PRINOS VERTICILLATUS. related to the Ilices or HoUys, differing chiefly in the number of its parts. Its character is formed by a sio? cleft cahjac^ a monopetaloiis subrotate si^c cleft corolla, and a sia^ seeded berry. The Prinos yerticillutus has its leaves deciduous, oval, serrate, acuminate, slightly pubescent be- neath ; fiowers ancillary, aggregate. These shrubs 'have usually been referred to Heccandria Monogynia. The present species and some others having different flowers on separate plants, Michaux was induced to place them in Dicecia. The natural orders to which they are assigned are Bumosce of Linn, and Rhamni of Juss. The Black Alder, for so the shrub is usually called, is found in swamps and about the edges of streams and ponds from Canada to the Southern states. It is irregular in its growth, but most commonly forms bunches six or eight feet in height. The leaves are alternate or scattered, on short petioles, oval, acute at base, sharply serrate, acuminate, with some hairiness, particu- larly on the veins underneath. The flowers are small, white, growing in little tufts or imperfect umbels, which are nearly sessile in the axils of the leaves. Calyx small, six cleft^ persistent. Corolla raonopetalous, spreading, without a tube. BLACK ALDER. 143 the border divided into six obtuse segments. The stamens are erect, with oblong anthers. In. the barren flowers they are equal in length to the corolla, in the fertile ones, shorter. The germ, in the fertile flowers, is large, green, roundish, with a short neck or style, terminating in an obtuse stigma. These are followed by irregular bunches of bright scarlet bierries, which are roundish, supported by the persistent calyx, and crowned with the stigma, six celled, containing six long seeds, which are convex outwardly and sharp edged within. These berries are bitter and unpleasant to the taste, with a little sweet* ness and some acrimony. The bark of the Black alder is moderately bitter, but inferior in this respect to many of our shrubs and trees. It discovers very little astrin- gency either to the taste, or to chemical tests. A decoction which I made of the dried bark underwent no alteration on the addition of dis- solved gelatin, and only changed to a dark green with the sulphate of iron. Alcohol produced hardly any change. The tincture, in alcohol, was found moderately bitter, and was not altered by water. The Black alder has had a considerable repu- liatioii as a tonic medicine, perhaps more than it 144? PRINOS VERTlCIliLATUS. deserves. The late Professor Barton tells us, that the bark has long been a popular remedy in different parts of the United States, being used in intermittents and some other diseases as a sub- stitute for the Peruvian bark ; and on some occasions, he thinks it more useful than that article. " It is employed both in substance and in decoction, most commonly, however, in the latter shape. It is supposed to be especially useful in cases of great debility accompanied with fever ; as a corroborant in anasarcous and other dropsies, and as a tonic in cases of incipient sphacelus or gangrene. In the last case," he says, "it is unquestionably a medicine of great eJB&cacy. It is both given internally and employed externally as a wash." Dr. Thacher recommends a decoction or in- fusion of the bark taken internally in doses of a teacupful, and employed also as a wash, for the cure of cutaneous eruptions, particularly of the herpetic kind. I have had but little experience with the bark of the Prinos which gave me much satis- faction. Indeed the tests of tonic remedies are of a more ambiguous kind than those of most other medicines. Vegetable barks, which are bitter and astringent, are generally tonic, if they BLACK ALDER. 145 have no more striking operation ; and in this property they differ in a degree somewhat pro- portionate to their bitterness and astriugency. Judging by these criterions, the Prinos is not entitled to hold a very exalted rank in the list of tonics. As a bitter it is at best but of the second rate, and in astringency it falls below a multitude of the common forest trees. The berries are recommended by the writers above cited, as possessing the same tonic proper- ties with the bark. They certainly possess some activity, which, in large quantity, is not of the tonic kind. I have known sickness and vomiting produced in a person by eating a number of these berries found in the woods in autumn. BOTANICAL REFERENCES. Prinos verticillatus, Linn, Sp. pi. — Pursh, i. 220. — Prinos Gro- aovii, MioHAux, ii. 236. — Prinos padifolius, Willd. Enum. Berol. 394. MEDICAL REFERENCES. B. S. Barton, Collections, ii, d,— Thacher, Lisp. 324, i4!^ PKINOS VERTICILLATUS. PLATE LVI. Fiff. t. Prinos verticillatus, a branch injlower:^ Fig. 2. Ripe berries. Fig. 3. Calyx magnified. Fig. i. The rest of the flower ditto. Fig. 5. Stamen of the barren flower magnified. Fig. 6. Crerm of the fertile flower dittOi ^^L.LVII ,^a-^M:f^CiX a/i^f^ W^v/d ^in/iin • '7«lT- J ■■ ■■:/':fr.v: /■ ,'.;.Vr.'.g