PTELEA TRIFOLIATA.
BY E. M. HALE, M.D., OF CHICAGO.
THE Ptelea trifoliata, of Linneus, is a shrub or small tree
of the natural order Rutaceme; or, according to earlier views,
of an order Xanthoxylaceae, or, still earlier, of the artificial
class Moncecia and order Tetra-pentandria, of the Sexual System of Linnaeus.
It is figured as follows:Miller, Icones, t. 211;
Gaertner, de Fructibus et Seminibus, pl. 49;
Schkuhr, Botanisches Handbuch, pl. 25;
Guimpel, Fremden Holzarten, pl. 74;
La M'arck, Planches de Botanique de l'Encyclopedie, pl. 84;
Duhamel, Arbres et Arbustes en Pleine Terre, 2d ed.,
vol. 1, pl. 57;
Dictionnaire des Sciences Naturelles, pl. 128;
Memoires du Museum d'Histoire Naturelle, vol. 12, pl. 26;
Gray, Genera Illustrata, pl. 157;
Dillenius, Horti Elthamensis Plant. Rar., pl. 122;
Payer, Organogenie, pl. 24;
Agardh, Theoria Systematis Plantarum, pl. 19;
Loudon, Arboretum Britannicum, vol. 5, pl. 59.
The Xanthoxylaceae included those Rutaceae which have unisexual flowers. The genus Ptelea has polygamous flowers, with
four or five stamens, with samaroid, two-celled fruit, but one



4
celled by abortion. Its name is the Greek for Elm, given because of the resemblance of the samaroid fruits.
Its six known species are all North-American. Three are
Mexican, - P. pentandra, P. podocarpa, and P. angustifolia. P.
mollis, of the Carolinas, is clothed with a silky pubesence. P.
Baldwinii, of East Florida, has minute leaves with obtuse leaflets.
The remaining species, Ptelea trifoliata, Three-leaved Ptelea,
Hop-tree, Wing-seed, Wafer-ash (known in Britain as Shrubby
trefoil and Tree trefoil, in France as Orme de Samarie a trois
feuilles, and in Germany as Dreiblittrige Lederblume), is indigenous throughout the United States, from the East to beyond
the Mississippi, and even to Texas, in moist, shady places, and
on the borders of woods and among rocks. It is a tall shrub,
but under cultivation at Gordon Castle, Bannfshire, Scotland, it
had, in 1835, reached the height of forty-five feet, with a trunk
fifteen inches in diameter, and with branches extending twentyseven feet from side to side.
Two varieties have been found, — one with five leaflets (P. pentaphylla, Moench); the other with the branches, petioles, and
under surface of the leaves clothed with a soft tomentose pubescence, even when old (P. pubescens, Pursh).
It was originally sent to England by Bannister, but, being
lost, was re-introduced by Catesby in 1724, from Carolina. It
is common in the gardens of Europe; and in the Jardin des
Plantes, at Paris, a tree may be seen, the crown of which had,
in sixty years from planting, attained a diameter of forty-five
feet.
[To this same Rue family belong the Xanthoxylum Americanum, Northern Prickly-ash, and X. Carolinianurn, the Pricklyash of the South. And in some respects they are medicinal
as well as botanical analogues of the Ptelea.]
Pharmaceutical History. - The bark of the root is the officinal portion. It yields its properties to boiling water, but alco



5
hol is the best solvent. It is, when dried, of a light brownish-yellow color externally, in cylindrical rolls or quills, a line
or two in thickness, and from one to several inches in length,
irregularly wrinkled and furrowed externally, with broad transverse lines or rings at short but irregular intervals, and covered
with a thin epidermis; internally it is yellowish-white, but becomes darker on exposure, and is wrinkled longitudinally. It is
brittle, with an almost smooth resinous fracture, granular under
the microscope, resembling wax. It has a peculiar smell, which
some describe as like that of liquorice root; but to me the bark,
and especially the tincture, strongly resembles in odor that of
the boiling linseed oil used in the manufacture of white paint.
The taste is peculiar, almost indescribable: bitter, resinous,
pungent, acrid, very disagreeable, speedily and powerfully acting on the mouth and fauces; and its pungency is persistent,
owing probably to the oil.
The tincture of the bark should be made with the strongest
alcohol: the addition of a small quantity of water causes it to
turn as milky as the balsam of Copaiva under similar circumstances.
A tinctureltrituration may be nlade from  the mother-tilcture,
and is a very eligible preparation.
The flowers, fruit, leaves, and bark of the branches, all possess the same medicinal qualities as the root, but in a less
degree. I have used the tincture of the hardly-ripe fruit. The
woody portion of the shrub is but feebly medicinal. Ptelein,
or the active principle, may be used in tincture, as it is perfectly
soluble in alcohol; but the triturations are preferable.  (See
Chemical History.)
I do not know that for medicinal preparations the fresh bark
possesses any superiority over the dried.  The bark should be
gathered in the fall, -at the time of its greatest strength, - after
its constituent qualities have been fully elaborated in its cells.
The leaves should be used when fully developed, but before the




6
ripening; the flowers, just before the petals drop; and the fruits,
just at the period of ripening.
The process of drying these portions should be conducted in
a warm, shaded place, with care that they do not become
moldy, or infested by insects of any kind.
CHEMICAL HISTORY.-An oleo-resin, improperly called Ptelein,
is considered the active principle of the Ptelea. It is described
as of the consistence of thick syrup or molasses, dark-brown in
mass, much lighter when in thin layers, and having a peculiar
odor, somewhat similar to that of the extract of liquorice, and
an oily, bitterish, acrid, persistent taste, peculiar and rather disagreeable, and acting powerfully on the fauces. It is soluble in
alcohol, ether, oil of turpentine, and rather imperfectly in alkaline solutions; insoluble in acids and water. It imparts a slight
milky color to water, and separates into two portions, one of
which floats on the water, while the other sinks. Acetic acid
added to the alcoholic or ethereal solutions does not disturb
them unless added in excess. Water added to the alcoholic
solution produces a milky color, precipitating the resin; added
to the ethereal solution, it separates the oil, which floats on the
surface.  The bark was not subjected to a chemical analysis
until 1862, when Geo. M. Smyser, of Philadelphia, presented an
Inaugural Essay to the Philadelphia College of Pharmacy, having for its subject Ptelea trifoliata. The following were the
experiments: —
" First. A cold infusion was prepared by percolating six
drachms of the powdered leaves with water, until six ounces of
liquid had passed. This was of a dark-brown color, had a bitter, aromatic taste, and an odor strongly resembling that of hops.
To a portion of this infusion a solution of bichloride of mercury
was added, which produced a dirty-white precipitate. And,
with successive portions of the infusion, sulphuric and muriatic
acids produced each a precipitate.  The infusion was also
coagulated by heat, showing the presence of vegetable albumen.




To a portion of the infusion a few drops of tincture of chloride
of iron was added, which produced a black color. To different
portions were added nitrate of silver, sulphate of copper, and a
solution of gelatine, all of which produced precipitates, indicating the presence of tannic acid. The portion which was precipitated by gelatine was filtered; and, with the filtered liquid, tincture
of chloride of iron produced a greenish-black color, which disappeared when the liquid was heated, showing the presence of
gallic acid.
" Second. An infusion of the fruit was prepared, similar to
that from the leaves. This infusion had a very bitter taste, and,
upon treating it as in the former experiments, the result was the
same.
" Third. Two and a half ounces of the powdered fruit was
treated with ether, —to deprive it of fixed oil,- dried and treated
with alcohol. To the resulting tincture, acetate of lead was
added, which threw down a large quantity of coloring matter
and some resin: the liquid was filtered, and treated by passing
sulphureted hydrogen through it to get rid of the excess of lead,
and then again filtered and heated to drive off the excess of
sulphureted hydrogen. To the liquid, yet warm, water was
added in drops until it began to produce a precipitate. It was
then placed on a sand-bath, and evaporated to a syrupy consistence: when it had cooled, it was agitated with an equal bulk of
chloroform; and, when allowed to rest a few minutes, it separated into two layers, the watery liquid being on the top; this
was decanted, and on evaporation yielded a small quantity of an
extract of a very bitter taste. I made repeated attempts to
obtain crystals from this extract, but without success. The
chloroformic solution, when evaporated, gave a soft, resinous
substance of a slightly acrid, bitter taste.
"Fourth. Three ounces of the powdered fruit was moistened
with equal parts of alcohol and water, placed in a percolator,
and the menstruum of alcohol and water passed through it until




8
it was exhausted. The resulting tincture was evaporated to an
extract, which was of a dark-brown color and a bitter, acrid
taste. One drachm of this extract was washed with alcohol,
which dissolved out a small quantity of a soft resin, which was
very acrid to the taste. The same part of the extract was
washed with ether; this dissolved a portion of it, and on
evaporation yielded a brittle resin, which was odorless and
almost tasteless. The part which remained after being washed
with the alcohol and ether was principally bitter, extractive
matter, and which had none of the acrimony of the extract."
MEDICAL HISTORY. - The first mention of the Ptelea in the
medical literature of this country is found in Rafinesque's Medical Botany.  He observes that "the leaves are vulnerary, used
for poultices, good for worms." In Louisiana "it is called Boispuant." He makes no mention of the bark of the root. It is
mentioned in Griffith's Medical Botany: " The native species
P. trifoliata. is said by Schcepf to be anthelmintic, for which
purpose the leaves and young shoots are used in strong
infusion.  The fruit is aromatic and bitter, and is stated to be a
good substitute for hops."
In Howard's Botanic Medicine, 1836, it is described under
the vulgar names of Heal-all, Ague-bark, Pickaway, Anise, and
Wing-seed.' The bark of the root is an excellent stimulant,
expectorant, tonic; useful in all cases of debility, and particularly
in agues.  It has been highly extolled as a remedy in consumption of the lungs, having been sold as a nostrum at a high price.
in this instance it was tinctured in whiskey."
In Dr. J. G. Jones's Eclectic Practice (first edition), it was
erroneously mentioned under the name of Staphylea trifolia, the
name of another shrub in no way resembling it. In the second
edition it was properly designated as Ptelea trifoliata, and
extolled as "' a pure, unirritating tonic, having rather a soothing
influence when applied to irritated mucous membranes." He
advises it " in the convalescence after fevers, and in debility con



9
nected with gastro-enteritic irritation.  It promotes the appetite, enables the stomach to endure suitable nourishment, favors
the early re-establishment of digestion, and will be tolerated by
the stomach when other tonics are rejected."   He prescribes
the cold infusion, half a fluidounce every two or four hours.
In the various eclectic medical journals have appeared, from
time to time, short articles alluding to its powers as a tonic.
(See Eclectic Mcd. Jour., Cincinnati, 1867, p. 159.)  King's
Dispensatory describes it, and, in addition to the above medicinal uses, says: "A tincture made of Ptelea in whiskey is reputed to have cured several cases of asthma, and it is said to
cause, in many instances where it has been used, a troublesome, ex
ternal ery.sipelatous inflammation, either general or local, but which,
if the use of the tincture be persisted in, finally disappears, and the
patient becomes at the same time cured of the disease for which he
was treated."
Jones and Scudder, in their Eclectic Materia AMedica (1858),
add: "We have found a saturated solution of it beneficial in
chronic rheumatism."  They asseru it to be "alterative, tonic,
stomachic, diaphoretic, excitant," etc.  Svudder has "known it
to be employed in epilepsy with decided advantage."
Dr. Kost (Mat. AMed., p. 631) has an article on Ptelea.
These crude uses and unscientific recommendations comprise
all that can be gleaned from eclectic sources up to this time.
It has formed the basis of many nostrums, "ague-cures,"
"tonics," and even I" expectorants."  In 1866, Mr. Chapman, of
Hudson, Michigan, manufactured a preparation of " Pepsin and
Wafer-ash," in which the pepsin was united with the tincture of
Ptelea, pure anhydrous glycerine being used as the menstruum.
This preparation is very extensively used by some physicians as
a chemico-dynamic remedy in dyspepsia, and very highly valued
for its curative virtues. In my own practice, and under my
observation, cases of atonic dyspepsia, with deficiency of gastric
uice, have been cured by this preparation, when the usual rem
2




10
edies failed to effect any improvement. A notable symptom in
all these cases was, profound depression of spirits.
The first homceopathic physician who used the Ptelea in any
form was Dr. P. H. Hale. Guided by the pathogenetic symptom found in King's Dispensatory, he gave it in some obstinate
cases of chronic erysipelatous disease; also in affections of the
bronchia and stomach, arising from the metastasis of such eruptions. He made some notable cures with the lower dilutions.
At the meeting of the Western Institute of Homceopathy, held at
Indianapolis, in 1867, Dr. Hale reported some of these cases,
but they have not yet been published. I have occasionally prescribed it for symptoms similar to those obtained in the provings, especially a variety of urticaria, in which the raised spots
assumed the appearance of a bruise. In a few cases it appeared
to relieve the pain and itching, and shorten the duration of the
disease. I do not know of any other clinical experience in the
homceopathic school.
Allopathic experience is very limited. The only report on
its use is to be found in Tilden's Journal of Materia Medica,
vol. 5, page 321, by Dr. O. F. Potter, of St. Louis, Mo.
History of the Provings.-In 1866, the American Institute of
Homoeopathy appointed me one of the Bureau of LMateria Medica. I selected Ptelea as the subject of my report, and offered
two prizes for the best two series of physiological provilgs, and
one prize of $50 for the best pathological proving on animals, " to
consist of all the symptoms observed during life, a record of the
pathological or normal appearance of each organ after death,
a microscopic examination of the diseased organ or tissue, and
any abnormal tissue or product."
At the time of the annual meeting of the Institute, in 1867,
I had received only four physiological provings. I did not, therefore, award any prizes, or send inll any report to the Institute,
except the request to be continued on the Bureau during the
next year. In the course of the year 1868, I received seven




11
additional series of physiological provings, but no pathological
experiment. I name the following provers in the order of the
excellence of their experiments:1. Prof. T. Nichol, M.D., of Belleville, (First Prize).
2. Drs. Fish and Train (Second Prize).
3. Dr. Winm. HI. Burt, of Lincoln, Ill.
4. Dr. Cowles, of Bloomington, Ill.
5. Dr. A. Cowperthwait, of Toulon, Ill.
6. Dr. C. H. Lutes, of Ligonier, Ind.
7. Dr. C. W. Pierce, of Ft. Smith, Ark.
8. Dr. A. V. Marshall, of West Cornwall, Vt.
9. Dr. E. Parsons, of Kewanee, Ill.
10. Dr. Hayward, of Romeo, Mich.
11. Dr. Hunter, of Bellefontaine, O.
Total, twenty-two provings.
PROVINGS BY PROF. THOMAS NICHOL, M.D.
Prover, thirty-six years of age; strong and muscular; of sanguine temperament, with fair hair and gray eyes. Has been
for a number of years accustomed to experiment with drugs,
and is easily affected by them.
FIRST PROVING.
April 16, 1867. —Being in perfect health, took thirty drops
of the strong tincture of Ptelea.  In a few minutes, roughllness of the fauces, with feeling as if vomiting would come
on. At twenty minutes to nine, A.M., sudden and unexpected
urging to stool. Stool at first of natural consistence, but towards the close thinner and diarrhceic, with slight tenesmus.
Passage accompanied by sweat on the forehead and head, though
the morning was cool. Half past nine, A.M. Slight but persistent
nausea, not at all disagreeable, somewhat resembling the effect
of a few inhalations of sulphuric ether.  Pressive feeling at the
base of the brain, with nausea, closely resembling the well



12
known Ipecac symptom: "Headache, as if the hair and skull
were bruised, penetrating through the bones down to the root
of the tongue, with nausea."  Flushes of heat, alternating with
chilliness, all through the day. Pulse 88. The appetite good
at dinner, but entirely absent at supper-time. At five, P.M., urging to stool, at an unusual time. Half past six, P M. stool,
with straining; the discharge thinner than usual. Slight, but
persistent nausea from nine till eleven, P.M.
April 17, quarter past seven, A M. - Thirty drops. Sleep during
the preceding night restless; languid and unrefreshed on waking. Feverish heat, lasting all day, accompanied by pains in
all the limbs, and nausea.  Disinclination for mental exertion.
Frontal headache all day, pressing from within outwards.
April 18, noon.-Forty  drops; immediately followed by
retching, with increase of the frontal headache. At quarter to one,
P.M., piercing pain shooting through the temples, with increased
headache and nausea. After dinner, increased nausea, with heat
of skin and profuse perspiration on the forehead; pulse 96,
small and hard. Half past one, P.M.  Inclination to vomit gradually passing off. In the evening, amelioration of all the symptoms; though still languid and drowsy.  Constipation; no
morning stool as usual, but at seven, P.M., small, hard stool,
after much straining. Sound sleep all night, but haunted by
firightful dreams.
April 19. -The symptoms were an exact copy of those
developed on the preceding day.
Four, P.M. - Forty drops. Resolved to let this dose act for
twenty-four hours, and then go on with more frequent doses.
April 20.-Awakened at one, A.M., by a pressing pain in the
stomach; a feeling as of a weight; worse on motion, and aggravated by pressure with the hands. Also a rising of bitter
fluid, with a deathly nausea, confusion of the head, and sweat on
the forehead. Thoughts chased each other through the mind, it
seeming impossible to fix the attention upon any one object.




13
This attack, which resembled acute dyspepsia, lasted from one
till five, A.M., followed by sleep until seven, A.M.; languid and
tired on awaking.  During the whole forenoon, sharp pains in
the right hypochondriac region
Half past three, P.M. - Twenty drops in water. At four, P.M.,
had sour risings from the stomach; heat of skin; pulse 96,
small and fluttering. Nausea all the afternoon and evening,
with splitting headache, incapacitating for mental exertion.
April 21, half past ten, A.M.-Thirty drops. Extraordinary
inclination to sleep. Bitter taste in the mouth; the tongue,
which had hitherto been clean, was coated with a yellowish fur,
and the nausea was persistent. No stool today (an unusual
occurrence).  Up to this date, the medicine had had no effect
on the temper, but to-day it produced fretfulness and irritability
without the slightest exciting cause.  Sleepiness excessive; went
to bed at eight, P.M. At a quarter past nine, was roused to go and
see a patient, and on awaking was attacked with a kind of nightmare; quite conscious, but unable to stir on account of a pressing weight in the stomach and whole front of the trunk.
April 22.-On rising, giddiness, with piercing pain through
the brain, accompanied by severe aching pain in the stomach.
Quarter past six, A.M. - Thirty drops. All day, from six, A.M.,
till three, P.M., urging to stool, with rumbling in the bowels.
Three, P.M. - Thirty drops. The sickness of the stomach less
to-day.
April 23, half past seven, A.M. - Thirty drops. Hard and difficult stool, with smarting of the anus after the passage. Three,
P.M. Tenderness of the splenic region, with soreness to the touch.
Four, P.M.- Thirty drops. Giddiness, with vertigo at five, P.M.;
vertigo long-continued, and, after it, increase of abdominal tenderness.
April 24, seven, A.M. - Forty drops.  The abdominal pain
extending more toward the umbilical region, and worse on
motion. On drawing a long breath, a sharp stitch proceeds




14
from the umbilicus, toward the back-bone, and the tenderness
on pressure is increased. Half past eleven, A.M. Sharp, cutting pains through the front of the brain, alleviated by pressing
it with the hands. Three, P.M. - Forty drops.
April 25. —Sleep last night restless and uneasy, awaking
unrefreshed and languid.  The abdomen much swollen, and
tender over its whole extent, especially over the splenic region.
Six, A.M. - Forty drops. Nine, A.M. Hard and difficult stool.
Ten, A.M. - Forty drops. Persistent nausea and vomiting,
with giddiness of the head, and a feeling as if unsteady in the
legs. Unfit for mental exertion all day, and toward the afternoon had to give up exertion of every kind.
Five, P.M. - Forty drops, and again at ten.
April 26, half past six, A.M. -Fifty drops. The giddiness of
head and reeling in walking much increased.
Three, P.M. - Fifty drops. Four, P.M. The pain in the splenic
region much increased, and the swelling evidently greater. Constant feeling of weight in the hypochondria when walking:
a dragging pain, which affects the right as well as the left side.
Six, P.M. — Fifty drops. Head confused and giddy when
retiring to bed, at half past ten.
April 27. —Head weak and confused.  Seven, A.M. -Fifty
drops.  Nine, A.M.  Attacked with too much giddiness and
vertigo to keep up.  Nausea and vomiting soon followed,
although no relief came after the vomiting; bitter taste in the
mouth; tongue dry and coated brownish-yellow; splenic pain
much aggravated. Hot and feverish all day.
I was obliged to discontinue the proving, as the effects were
so severe. I have had attacks before, but nothing of such a
bilious character. I insert the symptoms for the reasons given
by Dr. Dudgeon, on page 209 of Lectures on the Theory and
Practice of Homceopathy: "He (the prover) should be in
a good state of health, - not necessarily absolutely healthy, for
that is a rare property.  He may possess what is called an




15
idiosyncrasy, a weak point, and yet be perfectly capable of
physiological experimentation, and the symptoms developed in
him by virtue of this idiosyncrasy may still be received as part
of the action of the medicine; for what is this idiosyncrasy but
a tendency to be acted on by a specific with more than usual
severity? It is in fact only the predisposing cause heightened
in sensitiveness; and for the action of the medicine, as well as
of the morbific agent, a predisposing cause is always requisite."
SECOND PROVING.
Oct. 21, 1867, quarter to seven, A.M. - Ten drops of tincture.  Half past seven, A.M.  Slight nausea rising from the
stomach upwards, accompanied by roughness of the back part
of the tongue. A very mild nausea —by no means unpleasant- lasted during the whole forenoon.
Eleven, A.M. - Fifteen drops. At dinner the appetite not as
good as usual, though, before beginning the proving, it had
been keen.  Throughout the course of the meal, tile same
faint nausea persisted.  One, P.M. Aching pain at the base of
the brain, though the intellectual powers were as active as usual.
At four, P.M., ate a bunch of somewhat tart grapes, and all
the symptoms disappeared; the nausea and headache were
entirely removed in a few minutes.
Quarter past eight, P.M. -Twenty drops. At half past nine,
nausea, with rumbling in the bowels, accompanied by discharge
of flatus, with desire for stool. Nausea, and pressing pain in
the forehead; the pain presses from  within outwards.  No
passage from the bowels to day, - a very unusual occurrence.
At eleven, P.M., went to bed. Nausea aggravated by lying
down. Restless and tossing, and some difficulty in falling asleep.
Oct. 22. —The dreams during the niglht were so vivid and
lifelike as to seem, on' waking, as if he had been up all night.
In the morning, weak and languid; hands and feet hot and feverish; pulse 72, weak and fluttering.




16
Half past six, A.M. - Twenty-five drops. At half past seven,
ringing in the ears, with slight giddiness, the ringing lasting
from two to three minutes, and returning for the same length of
time half an hour later.  Little appetite for breakfast; the
bread seemed tasteless; no thirst.  Quarter past nine, A.M.
Transient giddiness, with heat of the head and face, especially
on the forehead.  Goes about his professional duties in a perfunctory manner, very unlike the fiery zeal with which he
usually combats disease and his allopathic step-brethren.
_Heaviness in the occipital region, with gloomy feeling in
the forehead. At dinner, all food seemed tasteless.  Three,
P.M. Faiit feeling in the stomach, with sourish rising.  The
nausea is much worse  on walking.  At quarter to seven
P.M., was weighing  out a trituration, and the mental confusion was so great that he had some difficulty in telling
what was the tenth part of 150 grains. Appetite, at ten, was
indifferently good, but food was still tasteless. Singing increases
the nausea, and aggravates the headache, causing shooting pains
from within outwards.  At quarter past eight, P.M., a squeezing
pain in the epigastric region.
Half past nine, P.M. —Twenty-five drops.  In  bed, the
griping pain in the epigastric region worse than during the
day, and the abdomen swollen, but not painful.  During
the night, heavy sleep, with less vivid dreams than on the
previous night.  Frontal headache, so severe that he almost
felt it during sleep; and, on  waking  at intervals during
the night, noted that it was more intense than during the
day.
Oct. 23.- The heavy, pressing, frontal headache still continues; the pain pressing fi-om within outwards, aggravated by
stooping. Less nausea; stomach now feels weak. Aching pains
with occasional stitching in the region of the diaphragm.
Twenty minutes past seven, A.M. —Twenty-five drops. At
Eight, A M., regurgitation, tasting of the medicine, but with little




17
nausea. Temper as good as usual yesterday, but to-day was
unusually annoyed by noise.  Headache, a stunning, pressing pain in the frontal region, closely resembling a chronic
headache, which he had had for many years, and which his master
in the institutes of homneopathy, Dr. Constantine Hering
cured with one prescription of Rhus toxicodendron. At dinner,
a complete repugnance to animal food, although there was
less nausea than on the preceding day. Unable to eat rich
pudding, of which he is ordinarily fond. At two, P.M., head
languid and heavy; unable to follow the train of thought when
reading what is b)y no means difficult. Strong inclination to lie
down and rest. At ten minutes past two, sour risings from the
stomach, with feeling of weight and uneasiness in the stomach.
Half past eight, P.M.  His intellectual powers moved slowly
and heavily, and had difficulty in recalling familiar things to
mind. At ten minutes past nine, P.M., slight vertigo, with a
choking feeling in the pharynx.  Took no dose, at noon or
night, to-day. All the afternoon, felt a curious malaise, which
prevented him firom  doing business with alacrity. Attended to
his duties as usual, but felt such an oppression and weakness at
the stomach that he had no heart to work. Stools, to-day and
yesterday, of usual consistence and slimy coating.
Oct. 24. — The sleep during the preceding night was heavy
but restless, with fantastic dreams, - practising medicine among
people of gigantic stature; suddenly the scene would change,
and his patients were about the size of peas. When awake,
during the night, felt that the weight at the stomach was much
worse than during the day. Conscious of the stunning headache before he was awake.  Extraordinary weakness of memory; was unable to recall the names of familiar people. Felt
feverish, irritable, and intolerant of noise. At breakfast he ate
some pudding; symptoms all aggravated at once, especially the
heaviness at the stomach and the difficulty of concentrating
thought.  One, P.M.  At dinner, complete disgust at animal
3




18
food, — unable to eat any, - and the appetite was very poor.
Quarter past three, P.M.  Eructations, tasting of rotten eggs.
Dry heat over the whole body, especially in the palms of the
hands; pulse 104, small and weak. Aching, pressive pain in the
temples, aggravated by chewing.  Aching pains in the back
part of the thighs. At four, P.M., liard stool, with straining.
Soon after, eructations, almost blringing on emesis.  HIalf past
four, P.M. Aching in the bowels while walking; on standing
still; pain aggravated by a deep inspiration; severe prostration
of mind. At ten, P.M., a sharp, cutting pain in the right hypochondriac region, aggravated by deep inspiration, sufficiently
severe to prevent sleep.
Oct. 25. — Sleep heavy and dreamn-haunted.  Quarter to
seven, A.M- Five drops. Splitting headache, aggravated by
stooping, moving the eyes, and by reading. Dull, heavy pain in
the right hypochondriac region, apparently on the convex surface of the liver.  No passage from  the bowels.  At dinner,
ate roast beef and pudding.  Pain and distress in the stomach
soon after, with feeling as if a stone were there.
Five, P.M. -Ten drops.  Throbbing pain in the epigastric
region, aggravated by full and deep respiration.  Urine is
deeper itn color, and scalds slightly during passage. Weakness
of mind very marked. Sleep good.
Oct. 26.-  Sleep was better last night; awoke with the usual
morning headache, with weight at the stomach. Aching of all
the limbs, especially of the flexor muscles. Half past seven, A.M.
Fifteen drops. At quarter to twelve, A.M., griping pains, with
rumbling in the right iliac fossa.  The epigastric region is sore
to the touch, and pressure aggravates the nausea.  Two, P.M.
Pain and soreness extending from the right to the left hypochondriac regions, but worse in the epigastric region; a feeling
of weight, aggravated by standing erect or sitting erect, and
relieved by stooping forward. Good appetite at dinner, but
the usual aggravation followed. Urine was high-colored, - the




19
"yellowish-red " of Neubauer and Vogel. At supper, voracious
appetite, followed by pain in the epigastlric region; despondency.
Slight swelling in the region of the liver.
Ten, P.M. - Twenty drops.
Oct. 27. — Sleep uneasy and unrefreshing, and with more
annoying dreams than before.  Awoke with dry heat over the
whole body, especially on the face and hands. The tongue was
coated yellow, and the papillae were red and prominent. Bitter
taste in the mouth, with dryness.
Quarter to nine. - Twenty drops. This morning the headache is so severe that mental exertion is a burden, and the
pain is materially aggravated by any attempt at study.  The
face is yellowish, and the slin feels dry and harsh. The diy
heat over the body continues, though the feet are cold. The
appetite is now voracious; food has not its natural taste; and
pain at the stomach follows every meal. The liver is perceptibly swollen, and sore on pressure, which causes a dull and
aching pain.
Nov. 1. - Has taken none of the drug since Oct. 27. Thle
effects mentioned in the proving have gradually declined. The
only new phase consists in a number of thoracic symptoms, which
have come on very gradually, and which now cause considerable
pain.  As the various gastric and hepatic symptoms declined,
uneasiness and difficulty in breathing came on, with dull pain,
especially in the right infra-clavicular region, accompanied by
hacking cough without expectoration. This has come on very
insidiously, and now the right lung is dull on percussion, especially in the right infra-clavicular region.  On auscultating the
region over the bifurcation of the trachea and the upper part of
the sternum (with Cammann's stethoscope), the respiration was
found to be tubular, the sound was higher ill pitch than the normal vesicular sound, and more rapidly evolved.  Expiration
and inspiration were of equal length, with a slight interval
between them. On making a full inspiration, sharp pains shot




20
from the sternum towards the nipples, especially that of the left
side. Pressure on the intercostal spaces close to the sternum
caused pain of a dull, aching nature. These thoracic symptoms
were better in the house, and aggravated by exposure to the
keen air.
Nov. 7. - The thoracic symptoms had gradually declined.
THIRD PROVING.
November 29, 1867, half past seven, A.M. —Took twenty
drops sixth dec. dil.  Ate a light breakfast at a quarter to
eight. Weight and fullness at the stomach in an hour afterwards, with dull headache, pressing from  within outwards.
The headache does not incapacitate for mental exertion, but
causes a languor and indisposition to work. At twenty minutes
past eleven, A.M., griping in the stomach, with sharp pain on
slight pressure. At dinner appetite very poor, after driving
in the cool air all the forenoon.   Twenty minutes past
two, P.M.  Rumbling in the umbilical region, with swelling
accompanied by slight vertigo, with sweat on the forehead.
At three, P.M., eructations of a bitter taste, with slight nausea.  Marked indisposition for mental work.  Ten minutes
past three.  Straining at stool, with increase of the vertigo.
Twenty-five minutes past three, P.M.  Increase of the headache, with marked forgetfulness.  In writing a letter, felt a
curious and unusual disposition to hurry through with it as
quickly as possible, hardly taking time to write the words. The
headache and vertigo were aggravated  by even a moderate
warmth of the room; all the symptoms agg ravated in a hot room,
and ameliorated in the cool air.
Quarter to nine, P.M. Twenty drops. At nine, P.M., involuntary discharge of flatus, with urging to stool.
November 30. -Sleep unusually deep and heavy.  Racking
frontal headache on waking, aggravated by rolling the eyes
upward. Weight in the stomach, with bloating of the abdomen.




21
Continued speaking, even for five minutes, causes stitching pains
in the diaphragm.
Half past seven, A.M. - Twenty drops sixth decimal dilution.
At quarter to eleven, A.M., the headache had been persistent; sharp pains shoot from the right to the left frontal
region.  At ten minutes before noon, eructations, with a bitter
taste in the mouth, causing nausea and abortive attempts at vomiting. At dinner, marked repugnance to butter and fatty foods.
A very moderate meal was followed in half an hour by a sensation of stuffing and fullness.  Headache a little better before
dinner; all hour and a half after, much worse, and aggravated
by mental exertion.  Stitching pains in the upper part of the
posterior tnediastinum, aggravated by deep breathing, and by
the recumbent position; this is accompanied by soreness of the
trapezius muscles.  Forgetfulness is even more marked than
yesterday.  The headache worse.  Half past three, P.M.  An
attack of vertigo, without any exciting cause, other than the Ptelea. Attack so violent as to compel discontinuance of writing
and to bow the head on the hands, closingr the eyes.  The vertigo was preceded and accompanied by mild nausea, with slight
griping pains in the stomach. During the attack the pains in
the posterior mediastinum  were aggravated.  At seven, P.M.,
urging to stool, but it merely resulted in the difficult discharge
of a few balls of hardened faeces.  During the whole day,
unusual indisposition to mental or physical exertion.
Half past nine, P.M. - Twenty drops.
Dec. 1. —Sleep broken and restless; and, at waking intervals,
hardly able to determine whether sleeping or waking. Unpleasant dreams during the whole night. Awoke at seven, A. M., languid and unrefreshed.
Eight, A.M. - Twenty drops.  At half past eight, dull aching
pains in the left scapula, aggravated by the slight exertion
of writing.  Ten minutes to nine, A.M.   Griping pain in
the epigastrium, aggravated by speaking and by deep respi



22
ration; pressure aggravates the  pain, and  causes nausea.
Malaise of body and mind; desire to lie on the lounge, and
"think of nothing at all."  Drowsy and sleepy during the whole
afternoon, with bitter taste in the mouth. At five, P.M., urging
to stool; a continued pressure on the rectum, but on attempting
to have passage it resulted in nothing.
Ten minutes to ten, P.M. - Twenty drops.
Dec. 2. —Sleep broken by dreams, at first of a frightful nature,
but, towards morning, lascivious. Awoke languid and unrefreshed, and with the feeling of being mentally unequal to the
business of the day.
Seven, A.M. - Twenty  drops.  After breakfast, ineffectual
urging to stool, as on the  previous day.  Lassitude andc'
weariness, with disposition to hurry.  At three, P.M., feeling of weight, and dull pain in the right hypochondriac region,
with qualmishness of the stomach. The feeling of pressure in
the rectum lasted all day, and, at five, finally resulted in the discharge of a small quantity of indurated faces, with only slight
relief. There is, apparently, a true torpor of the rectum.
Nine, P.M. - Twenty drops.
Dec. 3. - Awoke at six, with a bruised sensation in all the
limbs, especially worse in the muscles of the back. The sore,
bruised pain was increased by pressure with the fingers.
Eight, A.M. - Twenty drops. Hot, dry feeling, over the whole
body, with a sensation as of having slept without undressing, or
having sat up all night. The tongue coated yellowish, with red
papillae; bitter taste in the mouth, with absence of thirst. Appetite deficient, and food has an unnatural taste, as on recovering
from a long illness. Mental lassitude, as on the previous day.
The right hypochondriac refgion is swollen, and the clothes feel
too tight. Irritable mood; a very slight annoyance keeps recurring, to his mind, impelling him  to speak about it.  Better
able to study than on previous day, but difficult to concentrate
his thoughts. More forgetful than befor'e the proving; and yet,




23
by collecting the thoughts, able to recall things read many years
ago. Able to supply some additional items to a professional
paper, intended to be exhaustive. At four, P.M., the lumbar pains,
aggravated, with stitching pains in the right hypochondriac region, which is swollen. At half-past six, P.M., racking frontal
headache, with heat of the face and head.  Able to examine patients, but inclined to hurry through with it; and, in selecting
the remedy, inclined to follow Fred Humphrey's rule, — " First
impressions are the best."  The appetite good at supper; pressure on the stomach, and increase of the hepatic pains after a
lighlt meal.
Quarter past ten. — Twenty drops.  No stool today, but
continual urging in the rectum.
Dec. 4. —Awake nearly all night from the harassing nature of
the pains, especially in the back, -in all the regions, but especially the dorsal. Dry heat; most on the parts where the pain
is worst.  The hepatic pain is aggravated, also the urging in the
rectum. At breakfast, repugnance to butter; even a small
quantity aggravates the epigastric pain.
Three, P.M.- Twenty drops. All the symptoms are aggravated
in the warm  room  and ameliorated in the open air.  The
muscular pains are relieved by rapid motion in the open air,
though they are worse on commencing motion. Rumbling in the
bowels, with tenderness on pressure.
Dec. 5.-Awoke by the pains in the back; less in the limbs
than on the preceding day.  The pain accompanied by rumbling
in the bowels, with bloating and tenderness on pressure. Liver
feels heavy and sore, especially when lying on the left side.
Less pressure on the rectum than formerly.  The mental lassitude and forgetfulness continue. At supper, ate some sour
apple-sauce, when all the symptoms became milder and gradually disappeared. During the whole experiment, the urine was
redder than usual.




24
FOURTH PROVING.
Dec. 13, 1867, twenty-five minutes past noon. —Being in
excellent health, a little before dinner-time, took, five hundred
drops of the concentrated tincture. Before taking the dose, had
a good appetite, but, after swallowing it, found that he could not
bear the sight or smell of food, especially of roast beef. Rumbling
in the stomach, with inclination to vomit.  Chilliness and shivering over the whole body; could not keep warm, even by sitting
over the stove.  Confusion of thought, with hurriedness of
manner. Forgetfulness,- writing one familiar word for another
of similar sound. Pulse quickened from 72 to 104 in fifteen
minutes; small and hard. At quarter to one, P.M., on turning
the head to look at the clock, taken with sudden giddiness and
with faint feeling. Sick and faint, with a sudden shrinking
from any mental work. At five minutes to one, P.M., the taste
of the medicine continually returning in gusts to the mouth;
a feeling as if vomiting would relieve.  Turning the head,
even gradually, aggravated the vertigo. At one, P.M., pressure
over the eves, aggravated by lifting the eyebrows. Sudden
sleepiness. Five minutes later, too giddy to sit up.  OGrdinary conversation in the room greatly annoys. Ten minutes
past one, P.M.  The qualmishness  increased, and  the old
pressure at the rectum  returned.  Rising from  the chair
aggravated the vertigo; the frontal headache was aggravated by
moving the eyes, and by noise; speaking aggravated the nausea.
Shivering in a warm room, and the head hot; shivering from the
hips downwards. Rising aggravates the giddiness, and also the
nausea. Burning and qualmishness at the stomach, with pain
on pressure. Attempting to walk aggravates the vertigo very
much; unable to stand alone.
Eructations, tasting of the medicine, with increased nausea;
bitterness in the mouth, with dryness.  Twenty-six minutes past
one, P.M. The pain in the head, the nausea, and the pressure




25
in the rectum aggravated by rising.  A little ordinary writing,
difficult, from vertigo and confusion of mind. Thirty-five min
utes past one. Pulse 126, small and thready; shivering, with
chattering of the teeth, scarcely comfortable near a large fire.
Ten minutes past two. All the symptoms ameliorated by a
walk in the open air.  Half-past two, P.M. Aching, drawing
pains in the left ankle, aggravated by motion; the pain extends
up the calf of the leg. Dryness of the mouth, with bitter taste.
Drawing pain in the left elbow. Ten minutes later. Extreme
forgetfulness.  Quarter to three, P.M. Violent urging to stool.
Three, P.M. Stool of more fluid consistence than usual, and of
very fetid smell; followed by renewed urging in the rectum.
The  passage is accompanied  by chilliness and shivering.
Twenty-five minutes past three, P.M. Marked dryness of the
lips and tongue, with hawking of mucus from the pharynx. Sickly
paleness of the face, especially around the eyes.  Languid and
dull, with little inclination for either mental or physical exertion.
Quarter to four, P.M. Shuddering and horripilation, with
eructations tasting of Ptelea. At Four, P.M., a griping, contractive pain in the stomach for half an hour. Half-past four.
The pain moved downwards to the abdomen. Quarter to five.
Urging to stool, and sudden discharge of a quantity of thin
diarrhoeic fteces, of cadaverous smell, with smarting of the anus.
Rumbling in the bowels after stool. Five, P.M. Rending pains
around the left knee, which come and go rapidly. Very little
appetite, after eleven hours' abstinence, with a strong repugnance
to butter. Twenty minutes past seven, P.M. Another stool of
the same nature as the previous one, yet somewhat thinner in
consistence, and even more cadaverous in smell. Lassitude of
mind, with disinclination to study; tasks performed in a perfunctory manner.  Thirty-five minutes past eight, P.M.  Griping
in the bowels, with swelling of the liver, which is tender to
pressure.
Retired at nine. Very sick indeed. After a restless, dream4




26
haunted slumber till one, A.M., awoke with a seated, dull, heavy
pain in the abdominal region, felt distinctly in the liver, which
was easiest when lying on the right side; also a feeling of pressure on the lungs, and of suffocation when lying on the back.
Lying on the left side, the liver dragging on its ligaments, and
swollen and tender even to a light touch. There is also griping
in the bowels, with rumbling, and pressure in the rectum. Abdomen bloated; pressure increased the griping. Rending, tearing
pains in the left scapula.  Head hot and feverish, with dull
aching in the frontal region, especially on moving the eyes.
Dry heat over the whole body, especially on the palms of the
hands. Restless and uneasy; unable to sleep. At half past
five, A.M., fell into a light sleep, and awoke at seven, tired and
unref'reshed.
Dec. 14. - Bitter taste in the mouth; tongue dry and coated,
light brown. Appetite at breakfast poor, with the usual repugnance to butter.  Eating a very small piece of cheese aggravated all the hepatic and gastric symptoms. All the symptoms
are better in the open air, though rapid motion causes sharp
pains in the right hypochondriac and epigastric regions.  The
griping and rumbling continue, and there is pressure on the rectum, such as precedes a dysenteric passage. Urine scanty, and
of a deep reddish-yellow tint. Labor performed in a perfunctory manner. Mind feels dazed and languid.
Quarter past eight, A.M. —A discharge of fbaces, coated with
slime. The passage is followed by tenesmus, which brings on a
small discharge of f(eces with a larger quantity of mucus, and this
again is followed by tenesmus. During the stool, shuddering with
chilliness of the sacral region; after the stool, smarting of the
anus, with itching. The dejection does not relieve the pressure
of the rectum, which becomes worse as night advances. Half
past ten, P.M. The pulse at 104, very small and weak. Eleven,
P.M.  A sudden attack of vertigo, lasting about one minute.
Quarter past eleven, P.M. Great dryness of the mouth.




27
Dec. 15. - Slept from midnight till about seven, A.M. The
pain in the forehead is deeper in the brain than it has been.
Pressure, as of a stone at the pit of the stomach, aggravated by
a light meal. Dry heat over the body, with sweat on the forehead. Eleven, AxM. A dull, aching pain in the small of the back,
aggravated by motion. Thirty-five minutes past eleven, A.M.
Acute, cutting pain in the spleen. Forty minutes past two,
P.M. Aching, drawing pains in the left scapula and shoulderjoint. Ten, P.M. All day had felt extremely weak. Remembered having heard Dr. Constantine Hering in his famous morning lectures, which, with characteristic kindliness, were without
money and without price, lay down the position that "provers
generally indulge in superlatives."  Nevertheless, felt entirely
justified in writing "extremely weak."  Felt weak in every
limb,- weak in brain, weak in memory, thouglht, and will, as
if a powerful and all-pervading disease had fastened upon him.
Dec. 16. —Slept all night, though the sleep was dreamhaunted, as before. Became conscious of a dull, aching pain in
the small of the back; motion adds a sharp, sticking pain to the
dull one. Heavy, aching pain inl the liver, with deficient appetite. Half past eleven, A.M. Copious stool of fluid consistence
and bilious smell, with a very copious expulsion of ascarides.
Stool followed by tenesmus, and succeeded by itching and smarting of the anus. Had to work a good deal to-day, though weak
in body and mind.
Dec. 17. - Slept fi-om ten, P.M., till four, when he was awakened
by the severity of the lumbar pain, worse than yesterday morning. Weight and pain in the liver relieved by lying on the right
side; aggravated by lying on the left, which causes a dragging
pain.  Griping in the epigastric region, with dryness of the
mouth, yellow-coated tongue, and bitter taste. Weak and irritable all the forenoon, and with the frontal headache incessant
through the proving. Legs weak during the forenoon, with
drawing pains in the knees and the flexor muscles.




28
Dec. 18. -One long and remarkably vivid dream all night,
till four. Awakened by hepatic and gastric symptoms, all of
which are aggravated towards morning. The urine, all through
the proving, of deep reddish-yellow, and small in quantity. No
stool all day. Appetite better than on former days.
Dec. 19. - Last night sat up till half past eleven, with a view
of testing whether the early waking was a result of the
remedy, or a mere accident. Was very sleepy when he went to
bed, but, nevertheless, awoke about half past three. The gastric
and hepatic symptoms were milder than they had been. Forty
minutes past seven. A stool of natural consistence, smell, and
appearance. Appetite at breakfast very poor, with muddled
feeling in the head. Ten, P.M.  All the symptoms have declined to-day, especially the headache.
PROVINGS BY DRS. FISH AND TRAIN.
Prover, twenty-five years old, with nervo-sanguineous temperament; light hair, blue eyes, and light build; weight one hundred and thirty-five pounds; in excellent health, having been
free from sickness of any serious character for years; appetite
good; diet temperate, using coffee once a day; continued the
same during the proving as before; never used intoxicating
liquors in any shape, nor tobacco.
FIRST PROVING.
March 30, 1867, ten, A.M. -Took ten drops of the tincture.
Soon experienced a sensation of nausea, with a nervous pain
alternating from the left arm to left eye and parietal region.
Noon. —Ten drops. Dinner in half an hour, followed by
an empty feeling in the stomach.
Two, P.M. —Fifteen drops. Great lassitude and weariness
throughout the afternoon. Unusual fatigue after slight exertion.
Half past six, P.M. - Twenty drops. Nausea for a few minutes. In about an hour began to be feverish, thirsty, lips cracked




29
and sore, — an unusual occurrence with the prover. Slept soundly
during the night. Saliva very profuse; ran from the mouth
during sleep, and wet the pillow.
March 31, four, A.M. -Awoke (earlier than customary) with
some fever, accelerated pulse, parched mouth, and an awakening
of sexual desire. Took no medicine during the forenoon.
Slight, continuous headache, lowness of spirits.
Two, P.M. —Twenty drops one hour after a hearty meal.
Felt a burden in the stomach soon after, although previously no
discomfort was produced by the dinner. It all passed away in
two hours. Four, P.M. Felt very well; some lassitude.
Six, P.M.- Thirty drops. Within ten minutes, a full, throbbing headache, with dizziness and nausea; radial pulse, 68, but
very strong, so as to be readily seen. Headache continued the
same for half an hour, when it became sharp, and darted from
temple to temple; very painful, especially when moving. Urinated five ounces (two ounces more than normal quantity).
Naturalin appearance; no evidence of albumen or urea crystals
by tests. At seven, P.M., pain in the hypogastrium, in the region
of the bladder; continued fifteen minutes. During this time
the headache intermitted.  Headache resumed in the left zygomatic region. These aches are very changeable, shooting rather
quickly from place to place. Dull pain sets in about eight, P.M.,
in the umbilical region, quite severe, continuing half an hour.
All symptoms disappeared during the evening.
Half past nine, P.m. - Thirty drops. Urinated five and a
half ounces; clear. Retired soon after, and slept soundly
during the night.
April 1, five, A.M. —Awoke refreshed; saliva flowed from
mouth very profusely during the night; sexual desire increased;
flatulence. Pulse slow, strong, irregular, 60; urinated six
ounces; normal in appearance.
Six, P.. — Twenty drops. Slight return of the head symp



30
toms. In half an hour, full, pressive ache in the frontal and
temporal regions.
Eleven, A.M. — Thirty drops.  Stool, natural; headache, oppression at the epigastrium; unsteadiness and nervous irritability.
Half past one, P.M. - Thirty drops. Rumbling in the bowels;
constriction of the pharynx; painful sensations in the temporal
region, continuing over an hour.  During the afternoon, a sensation of languor and weariness spreads over the whole system.
Six, P.M. - Thirty drops. Dull, oppressive headache came on
while reading, about nine. Urinated six ounces; rumbling in the
bowels; perceptible increase in the flow of saliva. Retired at
ten. Slept well, with the exception of troublesome driveling.
April 2. —Awoke about six, A.M.  Took  no medicine
during the forenoon. Very languid; energy entirely gone.
Appetite normal; urinated seven ounces. Stool natural; borborygmus; considerable flighty headache. Took ten drops at
three, P.M., at fifteen minutes past, at half past, at four, and at
half past. The attendant symptoms were headache, oppression, pain in the stomach, evident signs of gastralgia, tenderness at the sternum, and sensitiveness to the light during the
whole day.
Five, P.M. - Twenty drops.  Slight nausea; pulse full and
hard, very irregular; feeling as of sand in the stomach;
urinated six and a half ounces, clear, normal. Retired at nine
with the usual feeling of malaise; head just ready to ache.
Slept unusually well; saliva not so troublesome.
April 3, six, A.M.- Awoke with desire to urinate; passed
seven ounces, clear. Unusual hunger, craving for acid food.
Twenty drops. Headache in the frontal and temporal regions.
Eleven, A.M. -Twenty drops. Headache; weariness; urinated seven and a half ounces.  Two, P.M.  Headache in the
occipital region, lasting half an hour, passing then to the frontal,
over the eyes, not very severe.  Six, P.m. —Twenty drops.




31
Passed seven ounces clear urine, natural stool. At ten, P.M.
urinated five and a half ounces. Uneasiness in the bowels,
with flatulence; unusual quantity of saliva, thin and watery.
Retired at quarter past ten.  Sleep disturbed by dreams.
Driveling.
April 4, six, A.M. - Awoke feeling much refreshed; no pains
or aches; urinated nine ounces. Took no medicine during the
day. The day passed with scarcely a recurrence of symptoms
till evening, when the feeling of uneasiness in the bowels (umbilical region) came on, increasing in severity until nine, when
it was almost intolerable. It was of a peculiar character, bearing down, sometimes spasmodic, and griping; sometimes sharp
and throbbing. Ten, P.M. Some relief, but a headache set in,
confined to the temporal regions. Urinated seven and a half
ounces. This really severe attack passed off by midnight, and
sleep brought entire relief.
April 5, half past five, A.M. —Awoke with the same pain in
the bowels as the night before.  Appetite poor; ate a light
breakfast, which seemed to afford some relief.
Nine, A.M. - Twenty drops. At quarter past ten, pain in the
bowels came on with redoubled vigor; headache also set in;
obliged to lie down; great increase in the amount of saliva;
urinated eight ounces.  One, P.M. Pain less; headache less;
appetite pretty good; ate a light dinner. Two, P.M. No pain for
an hour and a half. Three, P.M. A slight touch in the umbilical
region, disappearing in half an hour. Drowsiness succeeded, and
the slightest effort seemed to weary.  Five, P.M. But little
change; no prominent symptoms.  Retired at half past ten.
Urinated during the evening eight and a half ounces; stool
natural.
April 6. - Slight headache in the morning.  No trouble in
the stomach or bowels until after dinner, when, immediately
after eating, the stomach seemed perfectly empty; very troublesome sensation of goneness. Somewhat feverish; pulse natural,




32
rather full.  During the preceding days the fever-symptoms
had been absent. Some headache during the evening. Urinated
during the day twenty-five ounces. Stool natural.
April 7, half past five, A.M. - Headache set in upon waking;
continued during the forenoon.  Pulse 85, full.  Feverish;
thirsty, with a dry feeling all over the system.  Voided
twenty-seven ounces of rather clear urine.  No further symptoms.
April 8. —No symptoms during the entire day, except the
same nervous weakness of the eyes, experienced during the
early part of the proving.  Whole system  seems relieved.
Urinated twenty-two and a half ounces. Pulse natural; stool
natural.
April 9.- Slight headache in the morning.  Feels perfectly
well.
During the above proving, the appetite was generally good,
the bowels natural; respiration unchanged; pulse, first full
and hard, but, during the severe symptoms, quiet; again feverish and full at the close. Urine greatly increased in quantity,
in quality unchanged. Saliva very abundant; almost constant
driveling during sleep.
SECOND PROVING.
April 16, 1867.-  One week from the last record of the first
proving. During the past few days the prover has felt unusually well.
Seven, A.M.- Forty drops of tincture.  Slight nausea.
One, P.M. - Forty drops. Quick, sudden starts of headache
during the afternoon; malaise.
Seven, P.M. - Forty drops. A general change in the system
seemed to have taken place, and the former weary feeling
supervened, with tenderness of the abdominal viscera,- i.e.,
readiness to become painful. Retired at ten. Felt a strange
uneasiness in the bladder and prostate.  Smarting sensation




33
in the urethra upon urinating, rising out of bed for the purpose. Nearly ten ounces were passed. Smarting in urethra
continued for twenty minutes after urinating.
April 17, morning.- Felt well. Eight, A.M.- Sixty drops.
An immediate feeling of heaviness in the stomach; eructation of
wind; nausea; felt well in an hour.
Ten, A.M. —Sixty drops. Repetition of former symptoms.
Well again an hour after.
Three, P.M. - Sixty drops. Headache now set in. At about
five, the old pain in the umbilical region became a prominent
symptom. The headache and pain continued without intermission; both rather severe.
Ten, P.M. - Took sixty drops and retired. Passed a restless
night. Arose twice to urinate. Passed during the day and
night thirty-one ounces. Stool natural.
April 18, five, A.M. — Arose, feeling sore, tired, and sick.
Headache soon set in. Urinated nine ounces.
Eight, A.M. —Sixty drops. Appetite not very good. Umbilical region very tender; and seemingly on the point of aching.
Noon, ate a light dinner. Urinated eight and a half ounces.
One, P.M. - Sixty drops. During the afternoon noticed an
increase in the amount of saliva. Spitting became frequent,
though unusual in health. Headache severe.
Three, P.M. - Sixty drops. Pain in the umbilicus and stomach set in with vigor. Throbbing headache in the frontal and
temporal regions; very painful. Pain in the abdomen, very
severe. Nervous irritability of the eyes. Urinated six ounces.
Stool natural.
Seven, P.M.-Feeling very sick. Took sixty drops, and retired. Restless, and in pain all over the head, stomach, and
bladder. At eight, was obliged to get up and urinate; passed six
and a half ounces. Considerable burning in the urethra. Heat
in the region of the prostate. Pulse full, hard, tense, but not
rapid.  Skin dry and parched; lips cracked, although the
5




34
saliva is greatly increased in quantity, and keeps up a constant
driveling while lying on the face. Rolled around till after
midnight, when sleep gave some intermission to the constant
pain.
April 19, nine, A.M. - Arose with headache, feeling very sore,
tired, and disgusted with everything. Urinated about six ounces.
Pulse more rapid (90). Took one hundred drops, followed in
an hour by thirty-five more. Nothing experienced from  the
fresh doses until about half past eleven, when, on a sudden
movement, the headache became violent, and the whole abdominal region began to ache and pain. Rumbling in the bowels, followed at half past twelve by a diarrhleic stool, very
dark in color, and sulphurous in smell. Pulse much more natural than on the preceding day. Saliva very abundant. Appetite all gone; eyes sensitive to light; general malaise. Pain in
the bowels was eased but a moment by the stool. Three, P.M.
Symptoms unchanged. Half past fours Headache confined to
the left side. Abdominal pain settled to a steady, dull pain,
not so severe as before. Diarrhceic stool. Headache passed
off after the stool.  Abdominal pain the same.  Six, P.M.
Headache resumed. Relieved at nine, feeling better than the
night before, yet in much pain. Urine not measured during the
day; about the same in amount as the day before; saliva not
very troublesome.
April 20. -Same general feeling of malaise, tenderness and
pain in the umbilicus, and dull headache continued all day.
Slept most of the afternoon.  Three stools during the day,
rather diarrhceic; urine nearer the normal amount; pulse rapid,
-- from 80 to 90; saliva troublesome.
April 21. —Occasional headache; bowel pains continue.
Stools diarrhoeic. Diarrhceic stools continued a full week, when
the unnatural condition was removed. In a week more, the
tendency to headache had passed off, but it was full three weeks
before pressure on the abdomen could be endured without pain.




35
An unusual amount of saliva has troubled the prover ever since.
Urine natural in a few days.
THIRD PROVING.
Prover, twenty-one years of age; nervo-sanguineous temperament; light-brown hair; gray eyes; weight, one hundred and
twenty-five pounds; in good health; no constitutional disease;
temperate in habits, never indulging in the use of ardent spirits
or tobacco. The medicine was of the third dilution, prepared
with distilled water by the decimal scale, from Prof. Hale's
tincture. Diet unchanged during proving.
April 15, 1867, seven, A.M. — Took five drops. No symptoms. At eleven, took five drops. No symptoms. At six, P.M.,
five drops. Tickling in urethra after urinating. Urine deposits
muddy sediment.
April 16, seven, A.M. - Ten drops; dull headache set in
at about ten.
Half past eleven. - Ten drops. At two, P.M, urine increased
in amount, filled with whitish sediment. Sensitiveness of the
urethra; headache continues.
Six, P.M.-Ten drops. Feeling of nausea; pulse rapid at bedtime; oppressive headache over eyes.
April 17, seven, A.M. - Fifteen drops. No symptoms during
forenoon. Fifteen drops at half past eleven. Headache during
afternoon; soreness at pit of stomach; appetite poor.
Six, P.M.-Fifteen drops. Headache intcreases during evening; quite severe upon retiring. Urine more nearly normal.
April 18, six, AM. - Arose feeling restless and uneasy. Sleep
disturbed by dreams. Perceptible increase in sexual desire.
Awoke during night with nightmare.
Seven, A.M. - Took fifteen drops. No  special symptoms
during forenoon.  Took fif een drops at half past eleven;
pulse, small and rapid; thirst; furred tongue; poor appetite;
desire for acid food; headache; nervousness.
Six, P.M., fifteen drops. Diarrhceic stool; headache contin



36
ued; drank a great deal of water; retired at nine, feeling
unwell.
April 19, seven, A.M. —Took fifteen drops. Repetition of
symptoms of day before; diarrhoea; five stools during the day.
Half past eleven. —Fifteen drops. Headache during afternoon;
feverish.
Six, P.M. — Fifteen drops. Felt better during the evening;
urine, normal.
April 20, seven, A.M. - Slept much better than night before.
Took fifteen drops. Headache; some diarrhoea; no further
symptoms during day, with the exception of a diarrhoeic stool
and feeling of malaise.
April 21. —Awoke with slight headache, which passed off
during the forenoon; diarrhoea; urine increased in quantity;
pulse natural.
April 22.- No symptoms.
The diarrhoea passed off in the course of a few days, and no
further effects were experienced from the proving.
PROVINGS BY WM. H. BURT, M.D.
Prover of sanguine-nervous temperament, with a little of the
lymphatic; weight, one hundred and forty-eight pounds; habits
temperate, using no form of distilled or spirituous liquors,
tobacco, coffee, or the like. Health excellent; appetite good;
bowels move regularly once a day, generally in the morning.
FIRST PROVING.
April 20, 1867, six, A.M. - Took half an ounce of thirtieth
dec. dil., prepared by myself in rain-water.  Had a natural
stool before breakfast. At ten, A.M., had a stool of a mushy
character, with distress in the hypogastric region. At noon,
dull, pressive pains in the temples, with occasional fine, neuralgic pains in the temples. The headache is aggravated by walking. Headache continued all day, with eructations of sour fluid




37
from the stomach, and great lowness of spirits. A sour stomach
is something he is never troubled with.
April 21.- Great depression of spirits all day, with a black,
lumpy stool at two, P.M.
April 22, six, A.M.- Took half an ounce one hour before eating. Felt unusually well all day until eight, P.M.; then had
colicky pains in the small intestines every few minutes for one
hour; the pains were not severe.
April 23, five, A.M. -Mushy stool; another at ten, P.M. Unusually irritable all day, with slight, colicky pain in the epigastric region, and drawing distress in right hypochondrium. Legs
ached all day.
April 24, six, A.M.- -Half an ounce. Had a few sharp pains
in the arms in the morning. While in bed in the evening, had
fine, prickly pains in the fingers.
SECOND PROVING.
The thirtieth dilution produced so few symptoms upon him,
that he determined to use the sixth, prepared as before, in rainwater.
April 27, six, A.M. -Feeling well.  Took half an ounce
an hour before eating.  At half past six, severe distress in
the region of the spleen. Seven. Sudden, pressive pain in
the temples; it feels as if the temples would be pressed together; with distress in the epigastric region. Eight. Natural stool, followed by distress in the anus. Nine, A.M. Constant distress in the small intestines, with an urgency to stool.
Occasional flying pains in the abdomen. Dull, frontal headache,
feeling as if the temples would be pressed together. Drawing
pains in the left heel. Noon. Have had frequent distress in
the bowels. Two, P.M. Had severe nausea for five minutes,
with distress in the umbilicus, and dull, pressive headache.
Frequent fine pains in the fingers, and region of the spleen.
Nine, P.M. Languid all day, with aching distress in all the




38
joints, especially in the knees, ankles, and feet. All the evening
had a drawing, aching distress in the right hypochondrium.
April 28, seven, A.M. -Half an ounce, half an hour before
breakfast.  A number of times through the forenoon had a
feeling in the forehead as if it was being pressed together
from temple to temple, with severe distress in the region of
the spleen and right side of umbilicus; stool rather constipated.
Very languid all the afternoon, with severe. aching distress in
the wrists, knees, ankles, and feet. Fine, sharp pains in the fingers. Dull, aching distress in the small of the back.  Constant
aching distress in the whole abdomen.  The pressive headache
has troubled me more than any other symptom to-day, with the
aching in the back and legs.
April 29. - Awoke with severe backache, which passed off in
one hour. Seven, A.M. - Half an ounce, an hour before eating.
Several times through the forenoon had pressive pains from one
temple to the other; natural stool. Very languid from noon
until six, with flushed face and a feeling as if I had fever; but
the pulse was two beats below the natural standard. Constant
frontal headache, with severe pressive pains in the temples, from
one temple to the other, every ten or fifteen minutes.  Almost
constant cutting pains in the left umbilical and epigastric region,
with aching distress in the right hypochondrium.  Frequent
rumbling in the bowels, with desire for stool. Dull backache.
April 30. - Awoke with severe pain in lumbar region.
Seven, A.M. - Half an ounce, one hour before eating. Had constant pressive headache, with aching distress in the bowels, back
and legs, with great languor, all the forenoon. Natural stool.
Head, back, knees, and calves of the legs continued aching
severely all day, with rheumatic drawing pains in the elbows
and bowels. Fauces feel sore. Atmosphere quite damp.
May 1, 1867. - Languid all day, with aching distress in
the small of the back, knees, and calves of the legs. A number
of times through the day had hard, pressive pains in the temples.




39
Very irritable and desponding.  Natural stool.  Frequent
drawing pains in the right and left hypochondrium. Occasional
sharp pains in the stomach.
May 2. - Legs and back ached all the afternoon.  Several
times through the day had drawing pains in right elbow-joint
and fingers. Natural stool.
May 3. -Natural stool. Legs ached all the afternoon until
seven, P.M.
THIRD PROVING.
May 6, noon. - Feeling well.  Took half an ounce of the
second dec. dil., half an hour before dinner.  In the afternoon,
had hard, pressive pains at times in the left temple, with frequent
cutting pains in the epigastric and umbilical regions, and constant drawing pains in the wrists, knees, and ankles, worse in
the right knee and right wrist and fingers. Had very severe aching distress in the right knee all the evening; had repeated
colicky pains in the small intestines, lasting but a minute or two
at a time.
May 7. - Natural stool, morning and night, with colicky
pains in the hypogastriurn in the evening, before stool.
May 8, six, A.M. —Half an ounce.  In the forenoon had
slight distress in the abdomen, but all the afternoon had severe
aching distress in the whole lumbar and sacral region. Natural
stool, morning and night.
May 9. -Awoke with hard headache; passed off in a short
time. Natural stool.  Seven, A.M. —-Half ounce of the first
dec. dil. one hour before eating. At eight, A.M., sharp pains in
the umbilicus. Three, P.M. Excessive languor, with a feeling
as if he had fever; pulse 88, soft and weak, with constant
inclination to yawn. Five, P.M. For the last hour has had
colicky pains in the umbilicus, and drawing pains in the hands
and ankles.  Pulse 74; feeling much better.  Once in the
evening had hard, pressing pains in the right temple.




40
May 10. -Awoke with severe backache, which lasted about
half an hour.  Six, A.M. - Two ounces first dec. dil. one and a
half hours before eating. At eight, A.M., natural stool. Several
times in the forenoon had severe cutting pains in the right temple. Noon. For the last hour has had constant distress in
the right hypochondrium and epigastric region, with drawing
pains in the fingers and ankles.  Three, P.M. Very languid
and feverish; pulse 88.   Has had frequent cutting pains in
the umbilicus.
May 11. - Same symptoms as yesterday, but not so strongly
marked.
Had a few rheumatic symptoms for several days, similar to
the above noted.
FOURTH PROVING.
May 27, 1867, six, A.M. - Feeling well. Took forty grains
of the solid extract, prepared by myself from the bark of the
root of a Ptelea tree six inches in diameter.  In twenty minutes, sharp neuralgic pains in the right temple. In forty minutes,
dull distress in the stomach, with fine stitches in right temple.
Seven, A.M. Frequent darting pains in right temple, with constant distress in stomach (probably mechanical).  In one hour
and ten minutes after taking the medicine, ate breakfast, which
relieved the distress in the stomach. At nine, A.M., natural but
lumpy stool. Same pains in the temples. Tongue feeling as if
it had been scalded; the whole upper surface feels as after
taking Aconite.  Noon.   Has had, a number of times, fine,
sharp pains of a pressive character in the left temple.  Tongue
still has fine, sticking pains all over the upper surface. Frequent
distress in the stomach.  Aching distress in the calves of both
legs. Hands hot and dry.  Three, P.M.  Feeling  feverish,
hands are hot and dry, and ache constantly. Pulse 80. Occasional
pains in the left temple. At five, P.M., hard, dull, aching pains
in the wrists, hands, fingers, and ancles.  Nine, P.M. Tongue




41
has felt as if it were scalded all day; occasional pains in the
bowels. Languid feeling. Thermometer 62. Rainy day.
May 28. - Slept well; awoke very languid. Tongue coated
yellow, and feeling rough. Urine high-colored. Lumpy, darkcolored stool.
Six, A.M.- Took eighty grains. Ate breakfast an hour and
a quarter after. Eight, A.M. Dull headache, with a feeling
as if he had fever; breath seems to burn the nostrils. Tongue
feeling as if it had been burned. Nothing tastes natural. Distress in the epigastrium; had constant dull headache all the forenoon, with frequent paroxysms of pain in the right temple, as if
it would be pressed to the left side. Noon. Smarting of the
eyes.  Acrid feeling in the tongue.  Languid and feverish.
Rheumatic pains in the wrist, hands, fingers, knees, and ankles.
Four, P.M. Languid, with dull feeling of the head. Several
times through the afternoon and evening had sharp, colicky pains
in the umbilical region. Thermometer 70. Cloudy day.
May 29.- Slept well. Rough, flat taste in the mouth; tongue
yellow. coated along the centre and base. Natural stool.
Six, A.M. - One hundred and fiftv grains. In half an hour, hard,
pressive pain in right temple. Breakfast at half past seven.
Nine, A.M. Severe, dull headache, aggravated by walking upstairs. Stinging, biting sensation all over the tongue. Teeth
all ache and feel sore; increased flow of saliva that tastes saltish. Hands and fingers ache constantly. Ten minutes before
noon. Severe nausea for two minutes, with efforts to vomit.
Has had a severe dull headache all day, aggravated by walking. Increased secretion of saliva, with biting sensation in the
tongue.  Burning distress in the epigastrium  (not severe).
Slight colicky pains in the umbilical region. Dull, aching distress in the hands, fingers, knees, and ankles. Breath seems so
hot that it irritates the nostrils; pulse 74. Languid. At two,
P.M., soft stool. Nine, P.M. Same symptoms as in the forenoon,
but not so strongly marked.
6




42
PROVINGS BY MRS. S. M.
Under the Direction of Dr. Cowles.
Prover aged twenty-seven; of a bilious-sanguine temperament;
with dark-brown, or almost black, hair and eyes; of' decided, yet
mild, disposition; with strong constitution. A housekeeper. General health has been regarded good. Has been troubled somewhat with sedimentous urine, after the use of some kinds of
food. Some tendency to rheumatism. Requires about eight
hours of sleep regularly; subject to dreams, yet sleep is good
and refreshing. For some days previous to proving, found
urine as follows: Variation in quantity from  twenty-two to
thirty-five ounces; average for fourteen days was twenty-eight
ounces. When it was the least, it had some red sediment upon
standing. Weather mild and pleasant. No epidemic.
FIRST PROVING.
April 6, 1867. —Took ten drops of the first dec. dil. on
sugar, regularly three times a day, about one hour before eating.
Ten, A.M. Feels a trembling and weariness in the lower limbs.
Two, P. M.  Rumbling in bowels.  Four, P. M. Stitches in
shoulder and hip. Nine, P.M. Dull pain in left shoulder-blade,
and some unpleasant sensation in stomach; sticking pain in left
knee.
April 7. - On getting up, had a feeling of lameness in small
of back.  Urine during last twenty-four hours only sixteen
ounces, with reddish, cloudy sediment. Six, P.M. -Soon after
taking the drug, had a pain behind the right ear; also twice
during the evening.
April 8. -Lameness in back on getting up. Twenty ounces
of clear urine. Half past eleven. About half an hour after
taking drug, had a sharp pain behind the right ear, near the
carotid artery.  Three, P.M.  Hiccough; face burns; dull




43
pain in right side of head; pain behind right ear.  From  two
to six, slight burning in face, followed by rheumatic pains in
right leg and arm.  Nine, P.M. Pain in back of left breast
near the axilla; feeling rather languid; appetite somewhat increased.
April 9. - [lad dreams of food and awoke hungry. Dull,
rheumatic pain in anterior muscles of right femur and humerus,
which disappear after getting up.  Twenty-four ounces of rather
red urine. Afternoon. Some pain ini left biceps muscle. Six,
P.M. Pain behind right ear, in left temple and in back of neck.
Ten, P.m. Hard pain in left side of head, and behind right
ear.
April 10.- Slept pretty well, but had some dreams of food.
Awoke towards morning, feeling somewhat feverish.  Awoke
having hard, sticking pain in left temple, followed by a dull
headache, and cords of the neck lame on the right side; occasional stitches behind the right ear; pulse 104, quick, small, and
somewliat intermittent; mouth and throat dry; a faint feeling
in stomach.  About noon, headache, worse in left temple;
pain in back of neck; whole neck feels swollen; pain in right
mastoid process of temporal bone.  Two, P.M.  Pulse 84;
head aches, and feels large.  Three, P. M. Pulse 96; hot
flushes and pain iu top of head and eyes. For three days has
had no stool till to-day. Stool nearly natural. Rainy by spells
to-day. Feels sick all over and indifferent to duties. Went to
bed in the afternoon and soon to sleep. Awoke at five, P.M.,
with pain behind r-ight ear and in shoulder, near the spine of
right scapula; a lame spot on the inside of right knee as large
as a penny; otherwise quite well.
April 11.-  A cool night after the rain.  Had ten hours of
sound, refreshing sleep. Feels quite well; pulse 80; twenty-eight
ounces of clear urine in the last twenty-four hours. Lame spot still
felt; back somewhat lame on waking. Eleven, A.M. A few minutes after taking drug, had a very severe pain in the right ear;




44
had been ironing one hour. Pulse 92. Two, P.M. Severe backache, worse in lumbar region; transient rheumatic pains in right
side and right shoulder-blade; dull pain in region of liver. Had a
slight headache and an unpleasant feeling in the throat all the
afternoon. Five, P.M. Pulse 88, and occasionally intermitting.
Seven, P.M. Feels as though diarrhoea were coming; desire
for stool, tenesmus, but no stool. Heat and dryness of the
oesophagus, as before.
April 12. — Slept ten hours. Awoke three or four times
during the night with hard pain in the bowels; mouth and
throat very dry. Awoke with backache, and unable to speak
aloud for some time; a faint feeling. Twenty-one ounces of
clear urine in twenty-four hours. Pulse 75. Weary feeling in
the limbs; rheumatic pains in arms. Two, P.M. Pulse 106;
hot flushes and slight headache. Seven, P.M. Hard backache
the whole length of spine and back of neck; also through right
shoulder. Appetite good, but no stool for two days.
April 13. -Had a restless night, full of dreams, with some
fever. Backache in the morning, pain in the bowels, and constipation. Nine, A.M. Hard stool, and after it a smarting like
piles. Some backache and shooting pains through shoulder and
chest. Has taken no more of the drug since yesterday. Two,
P.M. Pulse 96, with burning cheeks and hot flushes.
Symptoms passed off in three or four days after leaving off
the drug. Less tendency to costiveness.
SECOND PROVING.
May 7, 1867.- The tasks incident to a change of abode have
required much more labor than usual. During the week past,
has had a rather profuse flow of urine of a light color, with
occasional rheumatic pains in upper and lower limbs, and neuralgic headache one afternoon, which was relieved by Aconite.
Bowels regular, not having been costive since ceasing to take
drug. Catamenia returned two days too soon, and quite copious.




45
The second experiment was with the sixth decimal attenuation. During the seven days of proving, took ten drops regularly three times a day. Weather warm and pleasant. No
epidemic.
No symptoms on the first day, except a slight headache after
a long walk.  During evening took slight cold.
May 8.- Thirty ounces of clear urine during last twentyfour hours. Soft stool at seven, A.M. Eight, A.M. Pulse 88.
Three, P.M. Pulse 82. No symptoms.
May 9. - Slept soundly all night, but dreamed of dead animals. Twenty-six ounces of' clear urine in twenty-four hours.
Nine, A.M. Felt a sharp pain behind the right ear; has not
felt one since the last proving, and never any before that. Increasing appetite. No stool to-day.
May 10.- Slept well and feels well. Twenty-six ounces of
urine in twenty four hours; pain behind the right ear at half
past eight, A.M. Increasing appetite. At seven, P.M., soft stool,
with tenesmus.
May 11.- Twenty-eight ounces of urine in twenty-four hours.
Slept very soundly. Hungry all the time; unusual energy to
work; in fact, feels better than before commencing the proving.
At night had a slight headache. Retired at eight, and slept
soundly all night.
May 12. - On awaking, had a pain in the small of the back,
which ceased after rising, leaving, for a while, a tired feeling.
Eight, A.M. Soft stool. At nine, A.M., felt a hard pain in the epigastrium, with slight feeling of nausea for about five minutes
and afterwards, three or four times during the day. Bowels
slightly distended at night, and feeling like diarrhoea. During
the day would be startled at slight, unusual sounds. Went to
bed early, and slept soundly all night.
May 13. - Feels lame in the region of the kidneys, on waking.
Soon after rising and taking drug, felt sharp stitches through
the right lung, which is sound. Soon after, had a pain behind




46
the right ear, which she felt certain was caused by the drug.
Bowels soon felt tendency to diarrhcea. Eiglht, A. M. Very soft
stool. At ten, a darting pain under right breast. From two to
four, P.M., headache on the left side, and sharp pain in left temple. Pulse 92.
May 14.- Awoke with headache and hunger, both of which
passed off after a hearty breakfast. Urine twenty-eight ounces
in twenty-four hours; clear.  Took last dose in this proving this morning. Rumbling in bowels.  Eight, A.M. Had a
sharp pain in left ear. Two, P.M. After a walk, lay down and
slept three hours. Awoke with slight pain near the heart, arnd
afterward shooting pain under the right breast. Pulse, on rising,
100; one hour later, 80. Natural stool in the evening.
Remarks. - Thinks the provings have improved the condition
of kidneys. Bowels nearly natural after first proving, but very
costive since the second.
PROVINGS BY MR. ALLEN C. COWPERTHWAIT.
Prover a student of medicine. Age twenty years; mentalvital temperament predominant; dark hair; gray eyes; weighs
one hundred and forty-two pounds;  height five feet eight
inches.
FIRST PROVING.
March 17, 1867. -Took five drops of sixth dec. dil., four
times per day,- one hour before each meal, and before going
to bed. Eleven, A.M. A severe frontal headache, lasting about
ten minutes. One, P.M. Dull frontal headache, lasting all the
afternoon.
March 18, seven, A.M.- Dull feeling, with sensation of weakness in upper extremities, which lasts all day. Towards evening the weakness extends to lower extremities.
March 19. - Nervous trembliing of hands. Pressure in frontal region, extending into root of nose, with a sensation as if a




47
nail was being driven into the brain on the left side. Symptoms
ameliorate towards evening.
March 20. - Before rising in the morning, sensation as of a
foreign substance in the larynx; on rising, pain in the right hypochondrium, disappearing on pressure.  Throat sore, growing
worse in the afternoon.  From  four to eight, P.M., aching of
right molar teeth, commencing in lower jaw and gradually ex,
tending to the upper of same side. After going to bed, colicky
pains in umbilical region, with a desire to press them, but pressure aggravates; better on rising. Stomach feels empty. Pains
shoot fromn right hypochondrium downwards.
March 21, ten, A.M.-Feeling as if the tongue had been cut
in the middle, and was just healing up. Two, P.M. Aching of
right molar teeth, lasting only a few minutes; returning at six,
P.M., lasting the remainder of the evening. Seven, P.M. Sore
throat; worse than yesterday.  After going to bed, colic similar
to that described yesterday, but not quite as severe.
March 22. — A dull, stupid feeling all day. 0C'ic pains came
on earlier than yesterday, and are of short duration.
March 23. —A feeling of dullness, and inability to pursue
studies; otherwise well.
March 24.  Took last of preparation last night. Three, P.M.
Throbbing pains in the right hypochondrium.
March 25.- A general depression of spirits; no appetite.
March 26. -All the former symptoms, but greatly ameliorated.
March 27, six, P.M. - Itching of the right ear.
March 28. -Right ear inflamed, and somewhat swollen.
March 29.-  Right ear broke out in white blisters on red
base; copious discharge of a watery fluid on puncturing; shiooting pains in ear, when lying on that side.
March 30. - Soreness and swelling of the lymphatic gland
under right ear.  Four, P.M. Steady, cutting pain iln right bypochondrium.




48
March 31. - Vesicles on ear dried up, and cuticle desquamating. Aching in outer edge of ear, when lying down, relieved by
pressure.
April 1. - No symptoms; perfectly well.
SECOND PROVING.
April 8, 1867.- First dec. dil. taken same as in first proving. Seven, P.M. - Aching of right molar teeth, lower jaw.
April 9. - On rising ill the morning, a feeling of pressure in
frontal region, and in root of nose; dull, frontal headache all
day.
April 10. - Soreness in the abdomen; occasional stitches in
right hypochondrium; some colic after retiring at night.
April 11. — Colic pains in the morning before rising, with
discharge of flatulence. Dull pains in the forehead; heavy feeling over the eyes; pressure in the nose. After going to bed at
night, colic, with emission of flatulence and borborygmus; awakens from sleep.
Friday, April 12.- Before rising, colic, with excessively bitter taste in the mouth; headache all through cerebrum; relieved
somewhat on rising; colic disappears on motion, but comes on
at intervals all day, with frequent discharge of wind from the
bowels. Occasional throbbing pain over eyes, first right, then
left; nervous trerabling of hands. Eruption under the right ear,
discharging a watery fluid.
April 13. -Dull, heavy feeling in the head; severe pains in
left iliac region, worse on motion, occasionally changing to right
side. In the evening, when first lying down, intense throbbing
pain, commencing in glans penis, and extending to left pubic
region, and gradually disappearing. When lying on the back, a
feeling of pressure on abdomen.
April 14. - Shooting pains in the head before rising in the
morning. Nine. A.M. Throbbing pains in left hip, lasting only
a few minutes. About noon, severe colic, which seems mostly




49
on the right side. Nervousness; an unexpected noise startles
and causes a shooting pain over the eyes.  Dizziness when
walking.  Nervous twitching of upper lip, extending to left
eye.
April 15. - Throbbing pains in gluteal region.  Cramp-like
pains in region of the heart. In the afternoon, a severe headache, with depression of spirits, and a feeling of anxiety about
some unknown thing.
April 16.- Headache over the eyes; weakness of the whole
body; the walls of the chest, especially, feel as if they would
sink in. Disposition to worry about something, he hardly knows
what. Throbbing pains over left temple, then over right; colic
pains below umbilicus.  After going to bed, severe throbbing
pains over eyes, first right, then left. Took the last of the drug
at night.
April 17. -Sensation of fullness in brain. When walking,
a cramp-like pain in the sacral region, left side, so severe that
he has to stand still until it passes off.
April 18.-  Occasional pains in  right hypochondrium,
shooting downwards. Cutting pains over right eye, sometimes
left.
April 19. - When bending the body, cramp-like pains in cardiac region. In the evening, walls of chest feel as if they had
not power to expand when breathing.
April 20. — Sensation as if food was lodged between the
teeth on right side, commencing on lower jaw, extending to
upper; teeth feel as if elongated. Throbbing pain over right
eye; intense itching on back of right hand.  Eight, P. m.
Throat sore on right side.
April 21. - Throbbing pain over right eye, sometimes shooting from the root of nose upward.  Two, P.M. Throat sore
on right side; passed off about four P.M. Seven, P.M. Some
colic pains in the hypogastrium; toothache on right side.
April 22 - Soreness and inflammation of fauces, worse on
7




50
right side; soft palate and uvula inflamed. Dorsum of tongue
sore on right side, causing painful mastication and deglutition.
April 23.- Throat ulcerated on right side; right side of
tongue inflamed, not swollen.
April 24. - Throat better. Throbbing pains in left temple.
April 27. -- No symptoms, except a dull frontal headache.
April 28. - Severe throbbing headache on rising; weakness
of the whole body; at times cold streaks run up and down the
spine; great hoarseness of the voice; breath hot, eyes heavy;
throbbing pains over left eye, also in right temporal region;
throat sore; when coughing, head feels as if it would burst.
April 29. - Headache seems to be more in the cerebellum.
In the afternoon, the nape of neck grows stiff, causing painful
tension when moving.
April 30. - Sweat all last night. In the morning everything
tastes and smells sour. Some throbbing pain in right temple.
Swelling of lymphatic gland under right ear.
May 1, 1867. -Felt better generally; some pains in head on
left side, but by evening the symptoms were all gone.
May 2. - In evening, intellse itching of right ear.
May 3. — Ear swollen, little white vesicles rising under epidermis. Shooting and throbbing pains in right hypogastrium.
A boil began to make its appearance on right side of forehead,
(the first in his life).
May 4. — Swelling of ear increasing. Steady pain in left
hypogastrium, continuing several hours.
May 5. - The white vesicles in ear assumed a purple tinge.
Swelling of lymphatics was disappearing.
May 6. - Ear not so much swollen.
May 7. - Desquamation of cuticle of right ear; the blisters
discharged water.
May 8. - A feeling of weakness through the whole body.
Nausea, and bitter taste in the mouth; tongue coated yellow;
headache; eyes heavy. Frequent eructations of wind from the




51
stomach; a distressing feeling of emptiness in osophagus.
Aching of right molar teeth, lower jaw, after going to bed; also
shlooting pains from left ear down to the spine.
May 9, seven, A.M. - Stinging pains iln right ear; great soreness of the ear during the day; the blisters on ear scab over,
and become filled with a greenish-looking pus; moving jaws
painful. Five, P.M. Pains in ear of intense throbbing nature,
worse on moving and exposure to the air. When walking, wants
to hold his hand over it; sometimes pains shoot from it to the
boil on forehead.
May 10. - Dull, heavy feeling in frontal region; face swollen
in front of ri-ght ear, and painful to the touch. The ear is not
painful to-day; some pus is discharged, and the scabs desquamate. After retiring, aching of right molar teeth on lower
jaW.
May 12.- A slight bruise on the large joint of little finver
of right hand inflames and suppurates, causing painful tension
of the finlgers of that hand.
May 15.-Ear healing up; boil on forehead discharges some
pus every day.
May 16. -Vesicular eruption on right hand, commencing at
the sore on little finger and gradually extending upwards.
May 17. The eruption appears under right ear, and gradually extends over the whole face and neck, and on right hip;
burning and itching sensation in the eruptions; on scratching,
they discharge water.
Saturday, 18.- Burning in eruptions, increased on exposure
to air; much worse to-day than yesterday.
May 19. — No more burning or itching; the eruptions
began to disappear, and by the 22d they were all gone, and
desquamation of the cuticle had set in. The boil on forehead
discharged no more, and by the 25th it had entirely disappeared. About the same time another one made its appearance on right side of the chin, which conltinued painful until




52
June 2d, when it discharged some purulent matter, and then
began to pass off; by June 5th, it was all gone, and from  that
date he experienced no symptoms.
During the above proving, he kept an accurate account of
the rate of pulse, and could not detect any change; once, April
28, the pulse ran as high as 90; but often, in apparent health, it
has been higher than that; average, during proving, 72. Kept
account of the specific quantity of urine, and found but little
change; standard, 1019,-average during proving, 1023. Since
the proving, one of the right molar teeth of lower jaw has commenced to decay, but whether the effect of the remedy, or not,
was uncertain.
GENERALITIES. — Right side principally affected; symptoms
more from right to left, from above downwards, and from within
outwards. Aggravated towards evening and on lying down.
Ameliorated on motion and on rising.
Note. -Dr. Bacmeister, his preceptor, thinks it will prove a valuable
antipsoric remedy: he has prescribed it in a case of eruption similar to
that described in this proving, and it worked like a charm, curing the case
in a few days.
PROVINGS BY C. H. LUTES, M.D.
Prover of nervo-bilious temperament; age thirty years; of
good health at the time.  Proving made with mother tincture,
taken in water.
FIRST PROVING.
February 22, 1867, two, P.M. —Took three drops.  Half
past three, P.M. - Three drops. Nine, P.M. (In bed); sharp,
thin pain across abdomen from side to side, half an inch above
umbilicus; comes in flashes, at intervals of about one minute;
relieved by pressure. Awoke in after part of the night with
heartburn, and a sensation of fine, violent agitation of all the
muscles of the body and limbs, worse in hands and fingers.
This sensation passed away gradually in about five minutes.




53
February 23, seven, A.M. - Six drops.  Nine, A.M. Sensation of intoxication; fits of vertigo, lasting three to five minutes, relieved by moving about, but worse on sudden motion.
Sensation as if all objects about him were in quick, violent
agitation.  Ten, A.M.  Sensation of cold and numbness in
hands; they feel clumsy and stiff, with tingling and prickling9 as
if recovering from cold. Eleven, A.M. Fits of vertigo not so
frequent, but more decided; worse on sudden motion and bending forward. One, P.M. Vertigo only when stooping.  Two,
P.M. Vertigo all gone, but head feels a little muddled. Took
six drops; no symptoms.
February 24, noon. - Seven drops.  No symptoms.  Halfpast five, P.M. — Ten drops. Six, P.M. Dull, heavy, passive
pain around the umbilicus, with a fine, active pain above umbilicus, across the abdomen; relieved by pressure. Seven, P.M.
No symptoms after supper.
February 25, nine, A.M.- Ten drops.  Eleven, A.M. Dull,
constant, heavy pain in the umbilical region.  Abdomen feels
hollow, empty, caved in. Took ten drops. No symptoms.
Three, P.M. - Fifteen drops. No symptoms.
SECOND PROVING.
April 15, 1867, nine, A.M. -Took five drops of the mother
tincture. Ten, A.M.- Fifteen drops. Eleven, A M. Felt languid and lazy; had no inclination to stir; aversion to all muscular exertion.; constant nausea, and feeling of uneasiness in
umbilical region; abdomen felt caved in.  Sensation of softness in abdomen, and as if its front walls were drawn in
towards.the spine; dull, heavy pain in umbilical region.  Abdomen weak, lax; sick; wanted to be let alone. Pulsations in
umbilicus isochronous with those of the heart.  One, P.M.
Symptoms gone.
Three, P.M. - Took ten drops. At half past four, P.M. -
Fifteen drops.  Five, P.M.  Dull, heavy, aching in region




54
of umbilicus; abdomen feels caved in, with sense of heat;
general feeling of muscular weakness; inclination to avoid all
exertion, mental and muscular; sensation as if the nervous system were resting; flushes of heat in abdomen.  Half past five,
P.M. Prickling numbness in hands; sensation as if they were
cold, and larger than usual. Six, P.M. Feeling in hands like
that produced by electricity. Symptoms in the abdomen nearly
gone. Nine, P.M. Beating in abdomen; tingling in hands and
fingers; head feels light; mind confused; intolerance of loud
talking.  A voice usually pleasant sounds very coarse and
rough; thought that it would produce spasms if he were obliged
to listen. Impression produced by the sound heard last continues a long time.
April 16, half past five, A.M. - Ten drops.  Ten, A.M. - Fifteen drops. No symptoms.
April 17, nine, A.M. —  Twenty drops.  Noon. -  Twenty
drops. In half an hour, a feeling of warmth in abdomen and
stomach; dull pain in abdomen; general feeling of intoxication.
Brain seems agitated, mind confused, pupils contracted; sensation as if all objects were in violent agitation; nothing seems
to be at rest. One, P.M. Symptoms all less marked.  Three,
P.M. - Symptoms gone. Took twenty drops; no symptoms.
Proving discontinued for want of time to attend to it.
Remark. - The above proving, though not very satisfactory
to the prover, was not spun out, and made up from imagination.
No symptoms were given but those well marked, and which
could not reasonably be attributed to any cause but that of the
drug.                                           C. H. L.
PROVINGS BY C. W. PIERCE, M.D.
Prover in good health, but having from birth a tendency to
unnatural desquamation of the skin.




55
FIRST PROVING.
Nov. 12, 1867, nine, P.M. - Took ten drops, mother tincture,
in one ounce of water. Slept well until two, A.M., when he
awoke, dreaming of fighting.
Nov. 13, seven, A.M. —Ten drops.  Nine, A.M.  A sharp,
darting pain through upper lobe of left lung, lasting only a short
time, but returning every half-hour; aggravated by descending
stairs; did not feel it after the first day.
Noon. - Ten drops. Appetite very good. A feeling of mental
uneasiness, wandering from onte subject to another.
Nine, P.M. -Ten drops.  Was quite hungry, but did not eat
very heartily.  Had most fiightful dreams; dreamed of getting
whipped, and killing snakes.
Nov. 14, seven, A.M. — Twenty drops.  Had an abnormal
appetite, but his food did not distress him. After eating, a feeling of liveliness and activity for one hour; next hour, gradual
passing off of cheerfulness, amounting to sadness, and a disposition to be displeased with everybody and everything. Could not
concentrate his thoughts. Soreness and weariness in lower extremities.
Noon. - Took twenty drops.  One, P.M. Felt a sharp, darting pain through left superciliary ridge, extending deep into
the head, lasting but a short time; would return at intervals,
whether in motion or not. A prickling in lower extremities,
almost like that of pins, mostly in popliteal space; on scratching, it burns like fire, but no change in color of the skin.
Nine, P.M. - Twenty drops. Dreamed as before. Had a dull,
heavy headache in frontal region; burning in the skin of lower
extremities like fire.  Could get more relief from rubbing than
scratching.
Nov. 15, seven, A.M. -Sixty drops. Feeling, as before, of
liveliness after eating, followed by great depression of spirits.
Red spots on lower extremities, alike in position on both; after




56
an hour or so, they would change to a purple color; there would
be no itching quite near or on the spots, but around on the
healthy skin. Weakness and depression all over the body,
especially in lower extremities.
Noon. - Took sixty drops. Felt all the afternoon as though
he would break out into a profuse perspiration, but did not.
Bright-red spots in various parts of the body, changing as
before to a purple color.
Ten, P.M.- Sixty drops. Could go to sleep quite easily;
was able to sleep only a short time, awalking from horrible
dreams, and covered with a profuse perspiration. Itching was
not so annoying while perspiring.
Nov, 16, seven, A.M.- One hundred drops. One hour before
breakfast counted as many as fifty spots on various parts of the
body, most of them on upper and lower extremities; one or two
on the chest. Itching more confined to the trunk. Discontinued the use of the drug for two weeks, during which time the
itching continued as annoying as ever. By getting in the least
degree excited or warmed, the spots would be as red as ever,
but in an hour or so would subside and assume a purple hue.
After the expiration of two weeks, could see where the spots
had been. The itching was as annoying as ever; it did not
produce any disorganization of the skin. As the spots disappeared, they became of a dirty-yellow color, somewhat like that
left by a bruise. Appetite remained quite good for two weeks.
SECOND PROVING.
Nov. 30, 1867. -Took ten drops of the first dec. dil. three
times a day for three days. Did not get any prominent symptoms, and discontinued the use of the drug.




57
PROVING  BY  MRS. W.
Reportcd by Dr. Pierce.
Prover aged thirty-five; of a bilious temperament; took the
dinug for thriee days.
Nov. 12-14, inclusive.-Three times per day.  The first day,
ten drops at a time; second day, twenty; third, sixty.  It occasioned quite an irritation of the skili, but not the peculiar spots
manifested in the preceding case.  The itchlling  was so intense
all over the body that she could not be induced to continue the
proving longer.  She described it as so many thousand fleas on
her; could not refrain from constant scratching.  Thle itching
was not worse at nighrlt.  The drug did not seem  to have any
other effect upon her.
PROVINGS BY A. V. MARSHALL, M.D.
FIRST PROVING.
To one hundred grains of sugar-of-milk, on which Prof.
Hale had dropped one hlundred drops of the tincture, the prover
added one and a half ounces of alcohol.  Of tlis solution he
took a dose four times a day, commencing with three drops and
gradually increasing, till, at last, lie took drachm  doses, until
the preparation was all gone. No symptoms could be found.
SECOND PROVING.
lIe then waited four days and commenced taking the first decimal triturtatiozn, in three-grain doses, four times a day, gradually
increasing the dose to fifteen grains, wllen fifty grains (all which
Dr. Hale had sent) were exhausted.  During the last three or
four days, there was a peculiar reddish-clouded appearance of
the skin over the whole body.  Aside from  that, he remained
perfectly healthly, taking his usual meals without tea or coffee.
Bowels continued to move once a day, as usual; would not
have known from his feelings that he had taken any drug. Two
8




58
days after discontinuing the drug, the clouded appearance of
the skin disappeared.
THIRD PROVING.
April 13, 1867.- Took one scruple of Ptelein, one-fifth, at
three different times on an empty stomach, and continued to
take it in the same manner for four succeeding days. Felt as
well as usual till evening, when suddenly had a severe urging
to stool; it was very loose and dark-colored. The diarrhiea
did not continue.
April 14. - Bowels regular.
April 15. - No symptoms.
April 16. —Rose with a dull headache, which wore away
after an hour or two.  Had  dreamed  of armies of soldiers rising out of their graves, and marching into the house.
Bowels regular.  Occasional pains in various parts of the abdomen throughout the day. Went to bed at half past eight,
P.M. Dropped to sleep, and at nine o'clock was awakened by
a painful urging to stool; it proved to be another attack of
diarrhcea; quantity small, but with much pain throughout the
bowels.
April 17. —Dull headache in morning. Had dreamed of
enemies prowling about the house. Felt a soreness about the
abdomen, aggravated more by bending the body in any direction
than by pressure. The soreness or heaviness of the bowels is
such as to incline him, when sitting or walking, to support the
abdomen with the hands, indicating a moderate degree of congestion of the abdominal viscera. Appetite about the same as
usual, except that he gets tired before he gets through eating.
Yesterday the tongue was slightly swollen, and had white fur on
it; more of swelling and fur to-day, with burning of the mouth
and lips as it touched with tincture of Aconite. After taking
the drug, had sour stomach and a dull, heavy pain, extending
around the small of the back.




59
April 18.-Rose with a headache; brassy taste in mouth;
stomach sour; bowels costive. anid not so sore as yesterday.
The soreness or lameness of the lumbar region is worse. Same
doses. Pain in the lower part of each lung in the evening.
April 19. - Rose with a headache and general soreness of
the body, and wandering pains about the limbs. Pain in lumbar region most of the time, and sometimes in the right hip.
April 22. - Symptoms similar to those on the 19th, except
there is less energy and less appetite.
April 25. - The symptoms have gradually worn away.
May 1, 1867. - For some days has felt free from the influence of the drug. Has no acquaintance with it, except from
these provings.  Would think it might be of use in treating
certain rheumatic cases in aged people, in which there is a
general soreness of the body and limbs; and especially of the
abdominal and lumbar regions, with alternate diarrhoea and
constipation.  Possibly it may be of use in some forms of
skin disease.
PROVING BY E. PARSONS, M.D.
Jan. 12, 1867, ten, A.M.-Commenced the proving by taking
fifty drops of the tincture. Noon. —Took fifty drops. After
this, experienced slight nausea and giddiness. Sharp, darting
pains through the forehead and temples.
Half past two, P.M.- Fifty drops. Half past three.  Confusion of ideas, and drowsiness.
Half past four, P.M.- Fifty drops.
Jan. 13, nine, A.M.- Fifty drops. Ten, A.M. A severe pain
in the region of the heart, lasting several minutes.  Eleven,
A.M. Severe pain in the left leg, three inches below the knee.
Half an hour after, severe darting pain in the right temple, and
throbbing pains in the left supra-orbital region. Fifty drops at
half past one, half past five, and at nine, P.M. Retired about
half past ten. Severe, sharp, darting pains in the right thigh;




60
pains seemed to be muscular, and lasting for several minutes;
also severe darting pains through forehead.
Jan. 14. -  Before rising, felt pricking pains through and in the
throat, particularly in the tonsils and larynx, lasting several minutes, and quite severe; roaring in the ears.  Half past eight. --
Fifty drops. Extreme lassitude; disinclination for mental labor
or bodily exertion.  Heaviness of the head, with a muddled feeling, and dull, aching pain in forehead. Took fifty drops at ten,
A.M., at noon, and at two, P.M. Giddiness, dullness, and languor.
Four, P.. - Fifty drops.  Soon after this experienced severe
darting and throbbing pains in the left supra-orbital region.
Eight, P.M. - Fifty drops, soon followed by a sensation as if
diarrhoea would come on. Sleep heavy, and troubled with
dreams of robbers, &c.
Jan. 15. -  Took fifty drops at nine, A.M., noon, and three,
P.M. Extreme lassitude.  Pain in left lung, lasting for several
minutes.  Roaring in the ears. Disinclination for mental labor.
Severe darting pains just above the supra-orbital ridge.
Six, P.. -Fifty drops. Severe darting pains ill righlt temporal
region.  Half past nine. -  Fifty drops.  Pain in carious tooth,
with extreme sensitiveness; soreness of the gums.  All tile teeth
feel sensitive, with a dull, aching pain. Pulse 85, regular, full;
normal pulse 75.  Ten, P.M.  Pain and rumbling in bowels,
as if diarrhoea would supervene. Severe frontal headache. The
pain throbbing.  Half past ten.  Pain and rumbling in bowels,
with copious evacuation.  Chilliness, with great sensitiveness to
cold air, and desire to be near the fire.  General feeling of
malaise, with aching in the lower extremities, and premonitory
symptoms of fever.
Jan. 16. —Took fifty drops at nine, A.M., noon, three and
seven, P.M.  Felt very badly all day. Dull. aching pain through
forehead and temples; roaring in the ears; severe pain in the
lower extremities, worse on standing.  Weakness, with disinlclination to move or study; chilliness, and extreme sensitiveness




61
to cold air. Pulse 85. Urine scanty, with copious deposit of
phosphates and epithelial scales.  Sp. gr. 1035.
Jan. 17.-Fifty drops at nine, A.M., noon, three, five, and
seven, P.M. -Felt better this morning, but in the afternoon felt
quite badly again, with pain in the forehead and temples, aching
in the lilnbs, dullness, drowsiness, and incontinence of urine.
Sp. gr. 1035.  A  free deposit of phosphates.  Constipation.
Pulse 80.
Jan. 18.-Fifty drops at half past eizht and eleven, A.M.,
two and six, P.M. Felt better in the morning, but in the afternoon and evening much worse again.  Pains to day worse in
the riglht side.  Pains in the right leg, below the knee, extending to the ankle.  Dull, acling pain i~I the small of the back.
Pain in right zygoma, and in the right temple; also in the forehead. Nose stuffed up; sneezing; soreness of nasal passages;
influenza.  Pulse 80. Urine frequent, rathler scanty, some scalding, and difficulty of retention. Sp. gr. 1030. Deposit less
copious.
Jan. 19. —Fifty drops at nine, A.M., noon, and four, P.M.
Felt much better to-day till half past four, when the pains of the
extremities, back, and head all returned.  Pains in head quite
severe at half past nine, P.M.  Pulse 84.  Urine scanty during
thle day; the scalding and difficulty of retention all gone.  Sp.
gr. 1030.
Jan. 20. - Took no medicine. Feel some better. Catarrhal
symptoms still continue, but less violent.  Pain in the llead,
limbs, etc., not so severe. Urine slightly alkaline; copious deposit of phosphates and urates, tinged with purpurine.  Sp. gr.
1035.
Jan. 21.- Awoke about two, A.M., with severe pains in fore.
head, roalming in the ears, and very severe pain in righlt kidney.
Very restless and uneasy, rolling and tossing about.  Could nIot
get to sleep for a, long time, from pain and restlessness.  In the
morninrg felt some better.  Pain in kidney relieved.  Slight




62
pain in the head, and roaring in the ears, which increase in severity towards evening. In the evening, while riding on cars,
had a severe pain in right forearm, lasting several minutes. Tile
pain seemed to be in the flexor muscles of the forearm.
This ended the proving; all the unpleasant symptoms gradually
disappeared, and at the end of a week he felt as well as usual.
Remark. -The prover was naturally of a costive habit, and
was costive when he commenced the proving. But, after taking
the drug, the bowels moved regularly every morning, without
any particular uneasiness, for two or three days, when symptoms of diarrhoea came on, which, however, amounted only to
one thorough operation as from cathartic action. After this the
bowels became constipated again, there being no movement for
two or three days at a time.
The appetite was much increased for the first few days of the
proving, after which it diminished. No particular loathing of
food, but rather an indifference to it.
The sexual appetite was very much increased for several days,
after which there was a total absence of sexual excitement, until
the medicine was discontinued.
PROVING BY A. HAYWARD, M.D.
Prover, aged thirty-seven, nervo-bilious temperament, health
good.
April 17, 1867, eleven, A.M.- Took two grains of the third
decimal trituration, and again at three, P.M.
April 18. —Sleep natural. No symptoms. Took doses of two
grains, at six and ten, A.M. Frontal headache. Two, P.M. -Two
grains. Dull headache throughout the head. Six, P.M. -Two
grains. Severe pains in forehead and occiput.
April 19.-Slept well. Very little pain in the morning. Four
grains at nine, A.M., and again at two, P.M. Head nearly fiee
from pain. Nine, P.M.- Four grains. Not much headache.




63
April 20. -Very little headache; sleep natural.  Doses of
six grains at six, ten, two, and six, P.M. Symptoms unchanged.
April 21.- No symptoms. Doses of ten grains at eight, A.M.,
noon, and four, P.M.
April 22. - Doses of fifteen grains at eight, A.M., noon, four,
and nine, P.M. No symptoms.
April 23.- Doses of fifteen grains at six and nine, A.M. No
symptoms. Two, P.M.-Frontal headache. Fifteen grains; and
again at five, P..; slight ptyalism and headache.
April 24, six, A.M. - Slight ptyalism and headache.  Twenty
grains; again at ten, and at three, P.M. Ptyalisrn, but head
nearly free fiom pain. Slight burning in throat and stomach.
April 25. — Doses of twenty grains at eight, eleven, A.M., three,
six, and nine, P.M. No symptoms during the day, except slight
ptyalism and a little dull headache.
April 26.- Doses of twenty grains at six and ten, A.M., and
three, P.M. Headache and slight sickness at stomach.
April 27 to 30. - Took doses of twenty grains four times a
day, about three hours apart. No symptoms, except slight headache and ptyalism. Tongue smarts and prickles, and burns a
little.
May 1 to 4. -Took daily four doses of twenty grains, three
hours apart. No symptoms
May 5 to 11. - Took daily three doses of twenty grains four
hours apart. No symptoms.
May 12. -Two doses of two grains, first dec. trit., six hours
apart. No symptoms.
May 13. - Doses of two grains at six and nine, A.M., three and
six, P.M. Slight salivation.  Out of medicine.
PROVING BY G. C. HUNTER, M.D.
Prover 45 years of age; temperament bilious, nervous, and
lymphatic, - bilious predominating; weight one hundred and
ninety-five pounds; slightly dyspeptic.




64
April 19, 1867. - Took five doses of thirty drops each of
the saturated tincture of the fresh root, commencing at half past
ten, A.M.
April 21. - Took six doses of thirty drops each.
April 22, eleven, A.M.- Took eighty drops, which was all
he had prepared.  He took in all four hundred and ten drops.
Could not say that he felt the slightest unusual symptom during
the time or since.  Concluded  that either his tincture was
worthless, or that he was not a good subject for proving it.
CLINICAL OBSERVATIONS ON PTELEA.
PTYRIASIS VERSICOLOR. A middle-aged man was covered with
this eruption on all parts of the body except hlands and face. I-le
had all the usual characteristics of the disease.  Eie had tried
Arsenicum, Kali iod. and Sarsaparilla, with no good results.
Ptelea, second dil., ten drops three times daily, cured the case in
six weeks.                                   E. M. HALE.
CHRONIC GASTRITIS.-A middle-a(ed woman had for several
years a constant sensation of corrosion, heat, or burning in the
stomach; occasional vomiting of ingesta, constipation; fever every
afternoon; lowness of spirits, and debility. She had taken Nux
vom., Carbo veg., Phosphorus, and several other remedies, with
only temporary benefit. Ptelea, second dil., ten drops in a spoonful of water before each meal, effected a permanent cure in five
weeks.                                       P. H. HALE.
ERYSIPELAS. -Two cases of erysipelas came under my treatment, in which quinia and iron had been used in large doses
without success, and rather with injury to the patient.  A rapid
recovery ensued after the use of Ptelea.      DR. MILLER.
ICTERUS, WITH HYPERXEMIA OF THE LIVER.-In severe cases of
this disease, I have found Ptelea an excellent remedy. Ptelea
primarily affects the liver; the stools are generally of a brown
or gray color, with considerable odor.        DR. MILLER.




65
ASTHMA. —In two cases of asthma, Ptelea was of more service
than any other remedy.                          DR. MILLER.
AsCITES. —I found Ptelea to cure a case of ascites of very
severe type after many agents had been employed without success.                                           DR. MILLER.
PHTHISIS.-Several cases of hectic fever, with purulent expectoration of a sweetish taste, but without any other chest symptom than a slight mucous rhonchus, and sibilant rate, were cured
completely with Ptelea.                         DR. MILLER.
RESUME OF PTELEA TRIFOLIATA.
[Explanation of Symbols. - (') A pathogenetic symptom not confirmed by
clinical experience. (*) Confirmed by clinical experience.  (o) Curative,
but not observed as pathogenetic.  (v) Verified by one or more other
provers. The symptoms in Italics denote the persistence of a symptom in
all the provings. With in Italics couples symptoms of two classes.]
MIND AND DISPOSITION.
1    ~ Great languor and indisposition for either mental or
physical labor (vvvv).
* Malaise of body and mind (vv); desire to lie down and
think of nothing at all.
Inability to concentrate the thoughts; they seem chasing
each other through the brain.
~ Complete incapacity for mental exertion, with headache (vv).
5     ~ Fretful and irritable at very slight causes (vv)... Compelled to give up any attempt at exertion in P.M.
Petformed his duties in a perfunctory manner.
~ Great mental confusion (vv).
~ The mind moves slowly and heavily; with difficulty in
remembering familiar things.
9




66
10    ~Extraordinary weakness of memory; inability to recall
familiar names.
* Peevish, irritable feeling, and intolerance of noise (v).
* Marked forgetfulness, with increased headache, and disposition to hurry when writing.
- Great forgetfulness, and yet an ability, on collecting the
thoughts, to recall things read many years ago.
* Confusion of thought, with hurriedness of manner; forgetfulness, with mistakes in writing. (From a large dose.)
15    ~ Sick and faint (v); desire to shrink from any mental
work.
~ Dull and stupid feeling (v).
~ Great depression of spirits, with sour stomach.
~ Aversion to society; a wish to be let alone (v).
- Annoyance and irritation from ordinary conversation (v).
20     -Liveliness for an hour after eating, followed by great
depression and sadness.
HEAD.
~ Pressive feeling at the base of the brain, with nausea,
closely resembling the Ipecac symptom; "Headache as if
the brain and skull were bruised, penetrating through all
the bones down to the root of the tongue, with nausea."
- Frontal headache all day (vvvv); pressing from within
outwards.
- Pressive pain in the frontal region, extending to the
roots of the nose, as if a nail were driven into the brain
(left side).
Piercing pain shooting through the temples (vv), with
increased headache and nausea.
25     ~ Splitting headache, with nausea.
~ Piercing pain in the brain, with giddiness, and severe
aching pain in the stomach.
~ Headache after dinner, aggravated by mental exertion.




67
*Sharp, cutting pains through the front of the brain,
alleviated by pressure.
* Racking frontal headache, with heat of the face and head,
and great desire to hurry his business.
30    ~ Heaviness in the occiput, with a gloomy feeling in the
forehead.
* Heavy, pressive frontal headache, worse at night, pressing from within outwards, and aggravated by stooping.
Stunning, pressing headache (a similar one was cured
by Rhus).
~ Head feels languid and heavy, with inability to follow a
connected train of thought.
* Persistent headache, with sharp pains shooting from the
frontal to the left parietal region.
35    - Frontal headache, aggravated by moving the eyes, and
by noise.
~ Frontal headache deep in the brain.
Sudden, pressive pains in the temples, worse in the
right (vvv).
Fine, neuralgic pains in the temples, worse in the right.
Constant dull headache (vv), aggravated by going upstairs, and by walking.
40    - Sharp, darting pain over the left eye, extending deep into
the brain.
* Throbbing pains over the eyes, from right to left.
-Shooting pains in the head, before rising in the morning (vv).
~ Throbbing pains over the temples, from left to right.
* Severe throbbing headache on rising, with great weakness.
45    -Dull, frontal headache, with depression and sour stomach.
- Headache intermitting with pain in the hypogastrium,
dizziness, and nausea.




68
* Pain in the left side of the head and right side of the
neck.
* Headache over the eyes (v).
* Sudden pressive pain in the temples, as if they would be
pressed together, or as if the right would be pressed to
the left (frequently recurring during the proving).
50    - Frontal and occipital headache (vvv).
* Headache while reading (v).
SENSORIUM.
* Giddiness on rising in the morning.
* Giddiness, with continual vertigo and increased abdominal tenderness.
* Giddiness of the head, and, when walking, reeling as if
intoxicated (vv).
55    - Giddiness and vertigo in A.M., so as to necessitate a recumbent posture.
~ Severe attack of vertigo, with increased headache, and
aggravation of all the symptoms.
-Sudden giddiness, with faintness on turning the head;
vertigo aggravated by even a gradual turning of the head.
~Vertigo and nausea, aggravated by rising to the feet,
also by walking; inability to stand without the aid of a
chair.
- Vertigo and confusion too severe to permit letterwriting.
60    - Sudden atttack of vertigo, lasting a minute.
* Everything seemed to be in violent agitation.
EYES.
*Twitching of the eyelids.
A shooting pain over the eyes when startled.
~ Nervous twitching of the upper lip, extending to left
eye.




69
65     ~ Nervous pain, extending from the left arm to left eye.
* Rolling the eyes upwards aggravated the frontal head.
ache.
~Pressure over the eyes, aggravated by lifting the eyebrows.
* Heavy feeling over the eyes (v).
- Pain in the eyes (v).
70     * Pupils contracted.
*Painful sensitiveness to light, with irritability.
EARS.
* Ringing in the ears, with slight giddiness.
Sensitiveness to sounds (v); impression of sounds last
heard continues for a long time.
-Intolerance of noise, and of loud talking; annoyance at
even ordinary conversation.
175    *.Easily startled at unusual sounds.
* Pain in the right ear.
Continuous pain behind the right ear.
Intense throbbing pain in the ear, worse on motion.
~ Itching of the right ear, with inflammation and swelling,
terminating in white blisters on a red base, discharging a
copious, watery fluid. (Occurred twice on the same spot.)
FACE, ETC.
80          Burning heat of cheeks and face (v).. Heat of head and face, especially of the forehead.
~ Yellowish face, with dry, hot skin (v).
~ Sickly paleness of the face, especially around the eyes.
* Pressure at the roots of the nose (v).
MOUTH, TONGUE, ETC.
85     - Feverishness and dryness of the lips, with thirst.  (Primary.)




70
* The lips cracked and sore, notwithstanding an abundance of saliva. (Secondary.)
* Burning, prickling sensation of the mouth and tongue.
* Much dryness of the lips and tongue, with hawking of
mucous from the pharynx.
* Great dryness of the mouth, with bitter taste.
90    - Great dryness of the mouth and throat (v).
~ Increased secretion of saliva of a saltish or bitter taste.
~ Drooling in the night, wetting the pillow.
~ Fine prickling sensation over the whole surface of the
tongue (vvv).
- Tongue coated with a yellowish fur; the papillae red and
prominent.
95    ~ Tongue dry and brownish-yellow, or light-brown (v).
Tongue swollen (v), and furred; white.
* Tongue coated yellow along the centre and base (v).
~ Tongae feeling as if it had been cut through the middle
and was now healing up.
* Tongue feeling as if scalded, or as after taking Aconite.
100' Tongue inflamed (vvv), but not swollen.
JAWS AND TEETH.
~ Dull, aching pains in all the teeth.
~ Teeth all feel sore, with increased secretion of saltish
saliva.
~ Pain in the right molar teeth; first lower, then upper.
Teeth feeling elongated, and as if something was crowding them apart.
105   ~ Pain when moving the jaws.
THROAT.
~ Roughness of the fauces, with nausea (v).
- Sensation as of a foreign body in the larynx.




71
* Slight vertigo, with a choking feeling in the pharnyx (at
evening).
* Soreness and inflammation of the fauces (vvv), soft palate, and uvula (worse on right side).
110   ~ Throat ulcerated and tongue inflamed (right side).
* Distressing feeling of emptiness in the oesophagus.
* Slight burning in the throat and stomach.
* Hiccough.
* Sense of obstruction in the larynx on waking.
115   -Great hoarseness; inability to speak aloud (vv).
TASTE AND APPETITE.
Appetite increased (vvvvv). (Primary.)
~ Unusual hunger; craving for acid food.
-Voracious appetite; food had not its natural taste; with
pain in epigastrium following every meal; despondency.
- Appetite poor (vvvv); but little appetite and no
thirst.
120   ~ Bread seemed tasteless; all other food tasteless or unnatural.
* Great repugnance to animal food; and to rich puddings,
of which he is ordinarily fond.
~ Grea repugna.nce to butter and fatty foods; even a small
quantity aggravated the epigastric pain.
* Disgust at the sight or smell of food, especially of roast
beef.
* The taste of the medicine continually returning in gusts
to the mouth, with a feeling as if vomiting would relieve.
125   -Very little appetite (vv), with great repugnance to
butter.
~Eructations tasting of the medicine, with persistent
nausea (v).
~Eructations tasting of rotten eggs.
~ Sour eructations (vvv).




72
~Frequent bitter taste in the mouth (vv), with dryness.
130   - Taste of brass on rising in the morning.
GASTRIC DERANGEMENTS.
* Slight but persistent nausea (vvv).
* Nausea and retching, with increase of frontal headache; aggravated by speaking.
* Severe nausea, with efforts to vo nit, for two minutes.
135   - Sensation of goneness, or an empty feeling in the stomach after eating.
Nausea, with distress in the umbilical region, and headache (vv).
- Increased nausea, with heat of skin and profuse perspiration on the forehead (vv), after dinner.
* Sensation of repletion and fullness after a meal.
*Nausea and vomiting, without relief from the frontal
headache (vv).
140   ~ Persistent nausea (vvvv) and vomiting, with giddiness
and unsteadiness of the legs; aggravated by walking (v).
Awakened at one, A.M., by a pressing pain in the stomach, as of a weight; aggravated by motion arid pressure,
accompanied with eructations of a bitter fluid, with deathly
nausea, confusion of head, and sweat on the forehead. (The
attack lasted four hours, and resembled acute dyspepsia.)
~ Eructations, which almost caused emesis (after stool).
~ Griping in the epigastric region, with dryness of the
mouth, yellow-coated tongue, and a bitter taste (v).
* Eructations of bitter fluid, with deathly nausea.
145   ~ Colic, with emission of flatus, and borborygmus (vv).
* Emission of flatus, relieved by motion.
Remark. - All the gastric symptoms were much aggravated after
meals.




'73
HEPATIC SYMPTOMS.
* Sharp pains in the right hypochondrium (vv).
~ Constant feeling of weight in both hypochondria when
walking; a dragging pain (vv).
* Sharp, cutting pain in right hypochondrium, aggravated
by a deep inspiration (while in bed).
150   ~ Occasional pains in right hypochondrium, shooting
downwards (v).
* Dull, heavy pain, apparently on the convex surface of
the liver.
* Liver perceptibly swollen and sore on pressure, causing
a dull, aching pain, with stitches.
* Awakened by a dull, heavy pain in the liver, relieved
by lying on the right side. A feeling, when lying on the
left side, as of the liver dragging on its ligaments.
Liver swollen, and tender to a light touch.
155   ~ Heavy, aching pain in the liver, with deficient appetite.
* Sharp pains in the right hypochondriac and epigastric
regions, caused by rapid motion.
-Awoke with hard, aching distress in the base of the
liver (v).
~ Hepatic and gastric symptoms, aggravated towards
morning, awaking the prover at four o'clock.
~Tertian ague, with profuse vomiting of bilious matters.
160   0 Attacks of quartan ague, continuing for two years, resisting many remedies.
STOMACH AND ABDOMEN.
* Tenderness of the splenic region, with soreness on pressure (vv).
Abdomen swollen and tender, with severe splenic pain
(vv).
10




74
* Severe abdominal pain near umbilicus (vvv). Worse on
motion.
* Sharp stitch proceeding from the umbilicus towards the
spine when taking a deep inspiration, with increased tenderness on pressure.
165   ~ A faint feeling in the stomach, with sourish eructations
(v).
* A squeezing pain in the epigastrium, worse in bed, with
swollen but not painful abdomen.
* Aching of the bowels while walking (v).
* Throbbing, griping pains in the epigastrium, aggravated
by a full, deep inspiration, by speaking, and by pressure,
causing nausea.
* Pain and soreness across the abdomen, and in the epigastrium (vvv), aggravated by standing or sitting erect,
and relieved by stooping forwards.
170   - Rumbling in the umbilical region, and swelling, with
slight vertigo, and sweat on the forehead.
* Rumbling in the bowels (vvvv), and bloating, with tenderness on pressure.
- Burning and qualmishness at the. stomach, with pain on
pressure.
* Griping, conltractive pain in the stomach, moving downwards (v).
* Griping, worse on pressure, in the bowels, with rumbling
and bloating.
175   ~ Pressure as of a stone at the pit of the stomach (vv),
aggravated by a light meal.
* Colicky pains in the small intestines (during the evening).
* Flying pains in the abdomen, with desire for stool.
~ Stomach feels empty after eating; a sensation of "goneness " (v).
- Severe aching distress in the left hypochondrium (vv).




75
180   ~ Frequent drawing pains in the epigastric and umbilical
regions (vvv).
* Stitches in the abdomen, relieved by pressure (v).
* Pain in the epigastrium, with nausea (vv).
* Severe pains in the left iliac region, changing to the
right; worse on motion.
* Severe, bearing-down pains in the bowels; spasmodic
and griping, or sharp and throbbing.
185   - Pain in the hypogastrium (vv) and bladder, with headache, intermitting during the paroxyms.
* Retraction of the abdomen (vvv), with pulsations isochronous with the heart.
~Soreness of the abdomen, aggravated by motion, and
relieved by carrying it with the hands (vv).
* Abdomen tender on pressure for three weeks after the
proving.
STOOL AND ANUS.
* Sudden and unexpected urging to go to stool, which was
diarrhoeic, with slight tenesmus, accompanied by sweat on
the forehead and head (vv).
190   ~ Urging before stool, with straining during a diarrhoeic
stool.
* Constipation (vvvv), with a continual urging in the rectum.
- Constant urging to stool, with rumbling in the bowels all
day (vvv).
* Small, hard stool, with much straining (vvv).
Hard and difficult stool, followed by smarting of the
anus (vv).
195   * Stools of usual consistence, with slimy coating, accompanied with straining and vertigo.
~ Involuntary discharge of flatus, with ineffectual urging
to stool.




76
~ Urging to stool, with difficult passage of balls of hardened faeces.
* Constant ineffectual urging to stool; a continual pressure
in the rectum (vv).
* Pressure in the rectum all day, resulting in the discharge
of a small stool of indurated faeces, with slight relief; apparently a true torpor of the rectum.
200   ~ Pressure in the rectum, with qualmishness, aggravated
by motion. (From a dose of five hundred drops. See,
also, the next five symptoms).
* Violent urging, followed by a stool of fluid consistence
and fetid smell; the passage accompanied with chilliness
and shivering; and, after this, renewed tenesmus.
- Urging to stool, and sudden copious discharge of thin
diarrhceic feaces, of a cadaverous smell, with smarting of
the anus.
- Pressure in the rectum, as in dysentery, not relieved by
a stool.
- Two stools in succession of faeces coated with mucus,
followed by tenesmus; during stool, shuddering and chilliness of sacral region; after stool, smarting of the anus,
with itching.
205   - Copious stool of fluid consistence and bilious smell; with
it was a very copious expulsion of ascarides.: Diarrhceic stools of a dark color, and sulphurous smell.
~ Distress in the small intestines before stool.
~ Mushy stools.
* Dark-colored, lumpy stools.
SEXUAL ORGANS, —  MALE.
210   - Intense throbbing pain in the glans penis, extending into
the pubic region, when retiring.
~ Increase of sexual desire at night.
~ Lascivious dreams in the morning.




77
SEXUAL ORGANS, — FEMALE.
* Catamenia two days too early, and quite copious (after
continued exertion).
URINARY ORGANS.
* High-colored urine (vv).
215   ~ Urine of a deep color, and scalding slightly during its
passage (v).
* Urine high-colored; the yellowish-red of Neubauer and
Vogel.
Urine redder than usual during the whole proving (v).
Urine scanty, and of a deep-reddish or reddish-yellow
tint, during the whole proving.
* Urine less, with a reddish, cloudy sediment.
220'Urine profuse, and of a light color; the quantity decreased and then increased during the proving.
* A deposit of muddy sediment in the urine; afterwards
whitish, with increase in quantity.
- Pain in the region of the bladder, with headache intermitting.
~ Pain in the stomach and bladder.
- Uneasiness in the bladder and prostate gland; obliged
to rise in the night to urinate.
225   ~ Pain in the prostatic region.
- Tickling and uneasiness in the urethra after urinating.
~ Smarting sensation in the urethra while urinating.
~ Burning in the urethra.
Remark.- The quantity of urine increased each day, and
afterwards slightly decreased (during two provings).
The condition of the kidneys improved by the proving.




78
RESPIRATORY ORGANS.
* Aching pain, with occasional stitches, in the region of the
diaphragm.
230   - Stitches in the diaphragm, arising from continued speaking.
* Stitching pains in the upper part of the posterior mediastinum, aggravated by breathing or a recumbent position,
and accompanied with soreness of the trapezius muscles.
* Pressure on the lungs, with a sense of suffocation.
- Uneasiness and difficulty of breathing, coming on as the
gastric and hepatic symptoms declined; with dull pain
especially in the right infra-clavicular region, accompanied
by- Hacking cough, without expectoration. This has approached very insidiously, and now -
235   ~ The right lung is dull on percussion at the apex.
During a full inspiration, sharp pains shoot from the
sternum towards the nipples; worse on the left.
- Pressure on the intercostal spaces, close to the sternum,
causes a dull, aching pain.
Remark. - These thoracic symptoms are better in the house, and
aggravated in the keen air. (Secondary.) By T. N. from
the tincture.]: Cough, with bursting headache, in the morning.
* A sharp, darting pain through the upper part of left
lung; frequently returning, and aggravated by stepping
downwards.
240   ~ Pain in the lower part of each lung, in the evening.
~ Stitches through the right lung, which is sound.
~ Pain back of the left breast, near the axilla.
~ Pain under the right breast.
~ Cramp-like pain in the cardiac region (v).




79
245.Dyspncea; the walls of the chest feel as though they
would sink in (vv).
BACK AND NECK.
~Severe aching in the lumbar and sacral regions (vvvv).
* Dull backache every morning on waking (vv).
* Hard, aching distress in the dorsal region, for an hour
in the morning (vv).
* Pains in the left scapula, aggravated by the exertion of
writing.
250   - Bruised sensation in all the limbs and back; worse on
pressure.
* Rending, tearing pains in the left scapula.
* Drawing, aching pains in tihe left scapula and shoulderjoint (vv).
~ Dull, aching pain in the small of the back, aggravated
by motion.
* Severe pains in the back, worse in dorsal region, disturbing sleep.
255   - Awakened by aggravated pains in the lumbar region.
- Hard backache the whole length of spine and back of
the neck, also through the right shoulder.
* Walking arrested by a cramp-like pain in the left sacral
region.
~ Lameness in the cords of the neck, right side.
* The whole neck feels swollen.
260   - Dull, heavy pain and soreness in the lumbar region.
UPPER EXTREMITIES.
* A tingling, prickling in the hands and fingers, like that
produced by electricity (vv).
- A prickling numbness in the hands, which seem larger
than usual and clumsy (vv).
- Fine, sharp pains in the fingers.




80
* Dull, aching distress in the hands and fingers.
265   ~ Hands and feet are hot, dry, and feverish (vv).
* Hands and fingers cold, numb, clumsy, and stiff (vv).
* Dull pains in the elbows and wrists.
* Frequent drawing pains in the right elbow-joint.
* Drawing pain in the left elbow.
270. Sharp pains in the arms while in bed, in the morning.
~ Rheumatic pains in the right leg and arm.
- Flying, nervous pain, alternating friom the left arm to the
left eye and parietal region.
* Stitches in the shoulder and hip.
~ Wandering pains and soreness in all the limbs.
LOWER EXTREMITIES.
275   ~ Aching pains in the back part of the thighs (vv).
Aching drawing in the left ankle, aggravated by motion, extending up the calf of the leg.
- Rending pains around the left knee; flying, fugitive pains,
which come and go rapidly.
Legs weak, with drawing in the knees and flexor muscles.
*Constant aching distress in the calves of the legs (vv).
280   ~ Severe, aching distress in the legs all day.
~ Hard, aching distress in the right knee all the evening.
* Aching distress in the knees, ankles, and toes.
~ Sticking, penetrating pain in the left knee.
A lame spot on the right knee.
285   ~ Throbbing pains in the left hip and gluteal region.
~ Wandering pains in the limbs and right hip.
Great weariness of the lower limbs, with trembling
(vvvv).
- Drawing pains in the left heel.




81
SKIN.
~ A peculiar reddish, clouded appearance of the entire surface of the skin, lasting two days (v).
290   ~ Red spots on various parts of the body, mostly on the
extremities, soon changing to purple, lasting two weeks,
with itching around the spots.
-Prickling, like pins, mainly in the popliteal space; itching and burning, like fire; alleviated by sweating.
~ Itching and irritation all over, like flea-bites.
* Eruption under the right ear.
- A boil on the forehead. [The prover never had one
before.]
295   - A slight bruise inflamed and suppurated.
-Vesicular eruption on various parts; burning and itching, aggravated by exposure to the air.
~ Profuse night-sweats.
*Hot skin, with profuse perspiration on the forehead.
* Dry heat over the whole body, especially the palms of
the hands and the face, with a feeling as if the prover had
been up all night; feeling worse when the pains are worse.
SLEEP.
300   ~ Sleep sound, but haunted by frightful dreams (vv).
~ Sleep deep and heavy; awaking with racking frontal
headache, aggravated by rolling the eyes upwards.
* The sleep is broken and restless (vvvvv), and disturbed
by frightful or annoying dreams.
~ Frightful dreams, awaking in a profuse perspiration (v).
~ Sleep restless, and disturbed by dreams and by drooling of saliva.
305   - Languid on awaking, and unrefreshed (vvvv).
~ Nightmare (v).
~ Dreams of fighting; of killing snakes.
11




82
* Dreams of seeing soldiers.
* Dreams of food.
310   ~ Dreams very vivid and lifelike.
* Sleep restless, dream-haunted, with pain in the liver
on awaking.
* Sleeplessness almost total, from harassing pain in the
back; worse in early morning.
~ Excessive inclination to sleep during the day.
~ Sleep restless and heavy, with fantastic dreams of practising medicine among Brobdingnagians and Liliputians.
315' Languid and drowsy by day, with bitter taste in the
mouth.
~ Sleepiness, though he had felt unusually keen, and had
enjoyed the full night's rest previous to taking the large
dose (500 gtt.).
Attacked with a kind of nightmare on being awakened
at quarter past nine, P.M.; quite conscious, but unable to
stir on account of a pressing weight on the stomach, and
whole front of the body.
FEVER, PULSE, AND HEART.
Flashes of heat, mingled with chilliness, all day. Pulse
88.
Cold chills running up and down the spine.
320   ~ Feverish heat, lasting all day, with pains in the limbs,
and nausea (vv).
* Increase of the nausea after dinner, with heat of the
skin, and profuse perspiration on the forehead. Pulse 96,
small and hard.
Hot, dry feeling on the body, with cold feet (v).
~ Dry heat over the whole body, with sweat on the forehead.
~Chilliness and shivering over the whole body, in a




83
warm room; inability to keep warm at the stove (after
taking five hundred drops).
325   - Pulse 104, an increase of 32 beats in fifteen minutes.
* Shivering in a warm room, with heat of the head; shivering over the legs from the hips downwards.
* Pulse 126, small and thready, seventy minutes after the
large dose; shivering, with chattering of the teeth; scarcely
comfortable near a large fire; but all the symptoms ameliorated in the open air.
* Shivering and horripilation, with eructations tasting of
Ptelea.
- Aching distress in all the joints, with great languor (v).
330   * Very languid and faint, with flushed face and feverishness (v).
- Rheumatic, drawing pains in all the joints.
* Pulse 72, weak and fluttering.
- Pulse increased twelve beats, soft and weak.
- Pulse accelerated (vvvv) and intermittent.
335   ~ Hot and feverish all day (vvvvv).: Hot breath, which seems to burn the nostrils.: Hot flashes, with pain in the top of the head and in the eyes.
- Profuse night sweats.
Pulse slow, strong, and irregular.
GENERALITIES.
340   - A curious malaise, with such oppression and weakness
at the stomach as to discourage all attempts at work.
- Great lassitude and weariness, with a disposition to
hurry through duties (vvv).
~ Extreme weakness of limbs, brain, memory, thought, and
will (v), as if from a powerful and all-pervading disease.. Aching of all the limbs, especially of the flexor muscles.
~ A fine, violent agitation of all the muscles of body and
limbs.




84
345   -Dullness, with weakness in upper limbs, extending to
lower.
* Great languor and indifference to duties (vvv).
~ Soreness of the whole body.
* Frontal headache during the whole proving.
* Rheumatic, drawing, or wandering pains throughout the
body.
350' Flighty, nervous pains in different parts of the body.
-Loss of energy (v); languor and depression of spirits
(Primary).
*Unusual aches and pains all over the body, especially
in the abdomen and head.
Singing increases the nausea, and aggravates the headache, causing shooting pains from within outwards.
Soreness and swelling of lymphatic glands under the
right ear.
355   ~ Great restlessness and despondency.
Irritability of the sensory nerves.
An unusual energy to work (secondary).
CONDITIONS.
The symptoms assume the form of a severe bilious attack.
All the symptoms suddenly disappear after eating sour things,
as sour grapes, or sour apple-sauce.
All the symptoms are better in the cool, open air (primary).
The thoracic symptoms are worse in the keen air (secondary).
The symptoms are all aggravated in the warm room.
The gastric and hepatic symptoms are aggravated by pressure after meals, towards morning, and after eating cheese, rich
pudding, butter, or any fatty food; but relieved by motion in
the open air.
The nausea is aggravated by lying down, or by noise.
The pains in the head press from within outwards.




85
The headache is worse after eating, or from mental exertion,
moving the eyes, noise, walking, going upstairs, stooping, or
warmth, or during the night, while in bed; but alleviated in
the cool, open air, or by pressure.
Predominantly aggravated in the warm room, after eating
fatty food, when lying down, or early in the morning, from noise,
or when stooping.
Predominantly alleviated in the cool, open air, when rising from
bed, or during continued motion, and by the use of vegetable
acids.
Directions. - From above downwards, from within outwards,
mainly in the right side, or from right to left.