MONOGRAPH ON DIOS C OREA ATIL L S AND DIOSCOREIN; THEIR PHYSIOLOGICAL EFFECTS, TOGETHER WITH THEIR USE IN DISEASE. BY A. M. CUSHING, M. D., ILYNN, XASS. DETROIT, MICH.: PUBLISHED AT DR. LODGE'S HOM(EOPATHIC PHARMACY, 51 WAYNE ST., BETWEEN LARNED ST. AND JEFFERSON AVENUE. Entered according to Act of Congress, in the year 1869, by EDWIN A. LODGE, In the Office of Clerk of the District Court of the United States, for the District of ~Michigan. THE DIOSCOREA VILLOSA and DIOSCOEImN are for sale in any cquantity desired, in tincture, dilution or trituration at Dr. Lodge's Honiceopathic Pharmacy, 51 Wayne street, Detroit, MIichi-an. Pound bottles,...................... $3 75 Eight oz. bottles,................... $1 75 Iour oz. bottles................... 1 09 Two oz. botttles,.................... 55 One oz. bottles,............ 30 Half oz. bottles..,.................... 2 Pure Dioscorein, $2 50 per ounce. DIOSCOPREA ~YLLOSA. [Reprinted from the American Holllceopatic Observer.] %WVe have the pleasure of presenltiing the mnost elaborat'e provin(gs of the Dioscorlea yet mnace. This rnedicine is onle possessing very peculiar and unique properties. Used at first, emlpirically by the botanic and eclectic school as a rermledy for bilious Colic, it was supposed to have but a narrow rangie of remedial action. Dr. Paine, of Philadc'elph-ia, was the first to snougt4est its remediat1l po-wers for prciunful disorders other than the abudomlinal viscera. The experniments of Dr. Paine, anod the pr'ovings of Dr. Burt ancld Dr. Nichol, bo th substantiated this reco:mmendation, alid proved the Dioseorea to be capable of affcting', profoundly, tile general system. Since these provitn's were nmade, the Clinicial experience of other physicians, as well as -imyself, have estlobished thie efact that Dioscorea will prove curative in neulgii e ia, anld rmnny othler nervous disorders, especially if they arce of a refexc clhatracter, and originate in some irritation of the abdominal plexus. The follo wing thoro-fg h experimients, together with those already published, will throw much light upon the sphere of action of this interestingo medicine. In justice to the,author wve will state the reasons why the manuscript came into our hands for publication ~ The Massachusetts St.ate Society of fered a prize for the best provings of Dioscorea, stipulatbinog hat the provings must be * New Remedies, Second Edition, p. 297. 4 DIOSCOREA VILL OSA. made by five different persons. When the time for receiving the provings arrived, Dr. Cushing's experinents were the only ones presented. Owing to the technical obstacles presented by the stipulations, the manuscript was returned. FIRST PROVING, BY A.'A. CUSHING, M. D. December 29, 1867.-At 9:30 P. mI., took 5 drops of the tineture. December 30.-At 8 A. Au., took 5 drops of the tincture. At 2 P. i., hurried, almost irresistible desire for stool; loose stool, with much straining and slight protrusion of the old hemorrhoidal tumor, followed by pain in both knees, worse on going up stairs; the right one worse. At 2:30 P. 3I., took 5 drops of the tincture. At 4 P. xi. sharp pain in the left inguinal region, extendinog down inside of leg. At 5 P. Ar. hard aching pain in left axilla; 10:30 P. ~i. dull grinding pain in left temple; sore pain in center of right lung. At 10:45 r. mr. took 10 drops of the tincture. Pain in both lungs; griping in the umbilical region; both knees weak; all the evening, biting, stinging, pain in corn on the second toe of left foot; shalrp pain in left inguinal region; clraping pain in left h ypochondrium. December 31.-Sleep full of lascivious dreams; emission of semnen during sleep; corns on second toe of both feet sore and painful. At 10:30 At. A., sharp, darting pain just below the left nipple, arresting motion, but relieved by motion; burning at the stomach; most of the evening burning and itching over both scapula; hard cutting pain in left inguinal region; sourness and burning at the stomach; most of the evening, pain in left inguinal region, with occasional chills. At 11 Ir. m. took 20 drops of the tincture; distress at stomach; had to unfasten my clothes; both knees weak; tightness across the upper part of the chest. January 1, 186S.-Sleep full of lascivious dreams; hurried desire for,stool, driving ime out of bed early in the morning; loose, watery stool, with shuddering, but no pain; both knees weak; discharge of very ofiensive flatulence from the bowels; constant desire fbr stool; bad smell in nose; dull pain in right t-enplie; numbness and tiugling of the fingers on right hand. At 9 A. ir., soft, slimy, lirht colored stool At 12 u., took- 10 DIOS'O.REA. VILLO SA. 5 drops of the tinc-ture. At 4 rP. ir., hi tr d grinling pain in -1-inLht knee. At, 0:30 p. j1j., kne1es wveak and treniole woien w ailkilo',; distress in bowels, with some desire for stool all the eveniniio; rumbling of bowels, andcl passing' large qualntities of flatulence. At 10 P. r., Cdistless att stomach; hard g'ri'idlnig' pti:, in rioght thumb first joint; cutting pl.il in fore finger of l'ig'ht hand. At 10:45 P. J1., took 10 drops of the tincture. Hard, shlrup pain above the left nipple, tihroug'h the lung, lasting' several minutes; dull pain in right tenmple; constant exciterent of genital organs, with firequent erections night and day. January 2.-Tn morning mouth dry and bitter; pain in left lung, above the nipple; pain in thle stom-iach and bowels. At 12 31., took 10 drops of the tincture. For two or three daySs past, my nerves have been uncommonly steady. At 10:30 p. -r., took 10 dclops of the tinctlure. On g'oilg to be1 (distroes'sitog pain) in ceioastrinurn extendimg into the bowels, lastillo a hiiilf horli; restless, cannot sleep; eyes siuait and sore. Ja.luary 3. — In morning mouthl dry and bitteri; heavy distressed feelihno in bo\wels; durino fofrenoon bad sinill illn lose. At 2 P. t[., butilno seinsation in left, lungt, in leogion of Inippllc. At a P. A3., sharp p ain right t iemlle. At 7 P.., sharlp p111ai in right thumb; during evenling, sharp pain ol inside of right knee; knees weak; pain in lumb.lr and sacral region; pain in center of right lung. January 4.-In morning mouth dry; fauces feel sore as fiom a cold. At 8 A. -r. took 20 drops of the tincture. All the torenoon felt as if I h}ad a bad cold; bunes aclle; pain in rio'lit temple a.1nd right nllo; ta111 chlilly n11-l hilr. September 11. —Eyes have been sore for several days, feel as if some large, smoothe substance under the upper lids. Septemuber 12. —At 7 A. ir. shlarp twristing pain in left occipital regolon, relieved by rubbing. At 9:30 P. Mr. took 75 drops of 15th dilution. Septermber 1 S —Awoke in the ni~ght with a faint, numb feelino, sitting- up in bcd increased thle faintness, lying down inc reased the mlltlb feeling; lying upon the back and pulling the hair in fionit of both ears for sonme time relieved it. At 7 A. M. sharp, eClraelpitg pn1- in rinhzt elbow. t 6 P. At P. lameness of hlum1albar rle'ion;1 sharp pain in epigy-tstriunm, relieved by sitting erect; r'iglt klnee lame and painfulf; hard pain in left temple and ntg'e of jaw; scrotum cold and moist; penis cold and no erections for severas1 dacys. Septembber 1 -. —At 2 A. Ai. sharp, darting pain in right heel; dartil' to the body, soon passing off; leaving a hard pain in right Linee; in morning'g eyes smart and look red. At 8 A. IA. ulgent (leerire io-' stool with sharp cutting pain in umbilical region e'xteniluing to the rectunnm, with shuddering during stool, anid chilly a ter stool, 32 hours after taking the medicine. (The dischag-ees firomn the bow-els occurred usually about 32 hours after talnino lar'-e dloses of the dilutions higher than the 7th or lo0th). At 8:45 slihairp ptain over i'ight eye; desire for stool. At 12 Mr. hard achingl plai in rigoit knee, relieved entirely by one dose of Ir-is versicolor 3ad. Foi two dcays no symptoms appeared, tlhen for on e -week hid friequent, hardcl, cutting pains in epigastrium. sometimes verv severe, also, sharp pains in mright tempile and riglht knee; ahgolost constant itching- of the rectum.- At one time it seem(id as if the old piles cured by the first proving would return, but fi-otunately did not. Septemnbeo r 2?4.-AAt; 2 P. mm. took 50 drops 15th dilution; in five nminutes took 10 drops Camphora 3d, to see if it would antidote the Tioscorea, but it seemed to increase -Lather than diminish the efleet. F'or half an hour felt sick at the stornach; during the!afternoon hl-td shi-LLp pain in the bowels and temples; a velry sBharp pain in left occipital region; during the evening severe DIOSCOREA VILLOSA. 17 pain in the bowels with discharge of large quantities of flatulence. September 25. —Early in the morning, urgent desire for stool, driving me out of bed; during forenoon, severe pain in occipital region, worse on right side; pain in temples; dull pain in the bowels; after dinner, dull pain in head, worse on back side; in evening, sharp cutting pain in bowels, aggravated by walking; at times a very severe, cramping pain in right occipital region. At 11 P. 3i. pain in right temple; cramping pain in left knee, posterior side; lumbar region quite lame, with phin in left inguinal region. September 26.-At 9 A. M., when walking, a severe, cramping pain at head of left fibula, was very painful, hindered me from walking. Occasionally in the forenoon and quite frequently in the afternoon, a severe, cutting, cramping pain in epigastrium, with a faint feeling as if a diarrhaea would come on, very distressing, extending to near the umbilicus; dreadfully troubled with incarcerated flatulence; dull pain in back of head; knees weak and painful; back painful and lame; bowels feel sore, aggravated by walking. September 27. Bad, distressed feeling in stomach all day, at times sharp and cutting, worse by stooping, at times had to walk around the room to get my breath; very bad after riding or walking, when sitting down; pain in head, cramping pain in knees; knees weak and lame; stools almost white. September 28.-Very frequently during the day, a dreadful, sinking, cramping, cutting sensation at the epigastrium and upper portion of the bowels, relieved by standing erect, or by pressure, almost arresting walking or breathing; sensation as if a diarrhcea would come on; could taste food for ten hours after eating; knees weak and painful; genitals cold and almost insensible; no erections for many days; dreadful distress in stomach and bowels; had to resort to medicines to attend to any business. PROVING OF DIOSCOREIN. BY A. M. CUSHING, M. D., LYNN, MASS. Male, 38 years, nervo-lymphatic, dark brown hair, grey eyes, bordering on blue, complexion about medium. I use neither tea, coffee, tobacco, nor liquor; am well and happy. Three years since, I had a severe attack of hemorrhoids, which left one tumor on the right side of rectum, that always protrudes at stool, and has to be replaced, and is quite troublesome. This tumor slowly but wholly disappeared during the proving. I am also inclined to have little pimples, with dark heads, over the face; these also nearly all disappeared during the proving. The preparations used were the three triturations, were each triturated with pure sugar of milk, one hour. All the preparations were made on the decimal scale. The tourth was made with distilled water; the fifth with equal parts of distilled water and alcohol; the others with pure alcohol; except the largest doses were made one -half pure water, to avoid the stimulating effects of the alcohol. November 11. —While making first trituration, irritation of nasal passages and sneezing; then irritation of fauces, and hacking cough.; later, violent itching of both eyes; then smarting of eyes, right eye worse. At 9 P. Ai. took 5 grains 1st decimal. November 12.-At 7:30 A. M. took 5 grains; stool darker than usual. At 5 P. M. took 5 grains; at 8 P. Ml. took 5 grains; at 10 P. M. took 5 grains. November 13.-At 6 A. M. awoke with sweetish taste in mouth, uneasy feeling in epigastrlum, and dull pain on bot}h sides PRO VING OF DIOSCOREIN. 19 of right leg, below the knee. At':30 A. Ar. took 5 grains followed by burning of left tonsil and left side of throat. At 11 A. ii. burnilg, then itchlin, of left tonsil; at 12 xi. took 5 grains; at 2 P.':. took 5 grains; at 7 pr At. took 5 grains, burning of fauces; at 9 J,. ir. sharp, but not very severe, pain between epigastric and unmbilical re(gions, relieved by standing erect; at 9:30 P. A. dull, stupefyin'r painm in temporal region, both sides; at 10 P. -Tr. took 5 glrains fbllowed by smarting of f:auces, and dull, dizzy feeling of head. November 1 4.-Dark stool. At 7 A. txr. took 5 grains; at 11. A. 31,. weakness of right knee; at 2 P. ar. pulling pain in front of both ears, as precedes vomliting; at 4 P. Mr. weakness of' right knee; at 6 Pr aI..weakness of right knee, tongue sore on side, near last molar tooth, ialkinco talking difficulb; at 10 P. -,%i. took 10 grlains. After taking medicine, discharlge of water fiom left -nostril and smartin;t of flaces, chilly over left scapula, smlarting of internal an le of both eves right one worse; itching of internal ears; ears ifeel stopped up; violent itching of left ankle on front side while walling November 15.-At 6:30 A. Ar. took 10 grains; at 6:45 sharp pain in left hlypochondrium; at 7:30 A. Tr. chills on back, cornmnencinrg over leftt sc-apula; at 3 P. ir. took 10 grains. During the evening' irritation of fuces, with inclination to cough; knees felt weak. At 10 P., i. took 10 grains. November 16. At 6 A. I left knee weak; at 7:30 A. 1r. took 20 gkrains, fbllowed by pain in fi'ont teeth, and burning of mouth land ftauces; at 10:30 A.:r. pain in middle of left fore-arm, betw een nln a and radiuts; at 12 ir. twisting pain at epigastriumn; at 2 r. Tr. dull, eon-lusei feeling in head during stool; at 10 p. Ar. sharp pain of shoit duration darting through the liver; at 10:30 P. Ar. took 20 grallins of second trituration. November 17. —At 9 A. 3r. took 20 griains; at 10 A. Ar. pain in right lung, opposite or at the side of the nipple very sharp, relieved. by pressule; at i5 P. ir. pain ill ight knee, at the head of the tibia, relieved by imotion; weakness of right knee aggravated by walkiog; c'ontinued( walling curedcl it. At 5 P. ri. vialent itching of the left airkle wrhen wvalking; sharp pain in epigastriumn r elieeved by eatinc'; sharp pain in both temples, not aggravated nor relieved by ridinol, walking, nor shakingo the head. At 9:15 p. Ar. took 4-0 orrain1s; at 9:30 p. Ar. sharp pain in left hypo-,llond(rium, at angle of' ribs; at 10 P. Ar. sharp pain in epigastriumn. Novenmber 18.- At 6 A. A. sharp pain in epigastrium. At 7 A. Ar. took 40 gr1ails. At 7:30 A. AL. sharp pain in left temple, with nalusea and chills, beoinring on back, worse over left scapula; during forenooo n pain at epigastrium. At 11:30 A. Ir. sharp 20 PRO VING OF D.OSCORQ EITLV. pain through right lung, at the side of the nipple. At 1 2 M. took 20 grains. At 12:30 dull pain inll left shoulder; afternoon left knee weak. At 5 P. mr. sharp pain in lower piortion of riglht lung', commencing in the back and darsting throuogh to the front. At 8 P. ii. took 20 grails. At 10 P. bTI too0k 40 Irains 3d attenuation. At 10:30 P. x. sharp parn at epiastriurml.i November 19.-At 2:30 A. rI. sharp pain:t epigastrlium, extendto left hypochondriunm1, lastni-o one ioni. At 3.. jainint fbelinel illg, came lera syncope; ac-ling pain l right luno' At 2 -P. x. took 40 grains; dull, drawing pain in right leg, fion hip to knee on inner and back side. At 5 A. Lr. preSSingt pain in left hypochondrium; violenit itbchin of right ankle on frSont side, extending over the joint while walking. At 8. P. i,Y. took 40 gralus. November 20.-: 30 t. t. took 40 ctralls. At 11:30 A. M. sharp pain in left lung, outside and parallel with -the nipple. At 2 P. i. tcook 40 gorains. At 3 P. rN sharp pain in nleft llnno, in region of nipple. At 5 P. mr. sharp, sore pain in epigastliluml. At 6 P.. numbness oi left hand and armL to the elbow, as if asleep, continuincg several minutes, worse at the little finger. At 7'P. i tearing pain thlrouglh the scapuila a-lnd 1n11g; ii' itation of lartynx and inclination to cough 1 hard panl at epigastrllinm; pain in the rioht knee at head of tibia; deep coi h, dull pain in head, seems to be deep in center of he'adl; dluing afternoon dull, lame pain in lun3bar region, extending down thie hilps to the legs. At 8:45 P. a. sharp, severe pain in left ichek or l. wer portion of temporal region, followed by dTy cotogh; dulll pain in riiht leg, whole length, on back sid, worse at buttock and Ieel; shlip pain at epigastriumn; severe pain at inicldle of left fiblila; belching of largec quantities of tasteless wind, relievingu the distress at the stomachi frl a minute. At 10 O 1. xi. severe dull pa)in in the back of' neek1 extendinig to back of' hlead and both shoulders, worse in left. At 10 p. ri. took 40 Ogr'ains. November 21. -In the mor'ning mouth bitter and1 sticky; tongue d y and stiff at sides; soreness and pain at epi-;astrmim; )ain'below right hypochondrlium and't the left of umbilicus nausea with chills; h aid, aicling pain:at head of right tibi;; throat sore and anm hboarse. At 7 A.:r. took 40 i-cins; linm bness of left ]hand and pricking pain in fore finger; pain t1hrongh left scapula and ling. At 8 A. Ai. hard, aching pain in lower third or left, forearm, ulna side, extendii(' to little finer. At 8:45 A. i. dull, grinding pain in middle of left foreairI, quite severe; severe, deep seatedl pain in left occipital reoionl; shia:rp pain in region of right nipple, hinderling breatiingi. At 1 2,. dizzy while eating; sore place on left side of lose quite painfhil, but no redness nor swelling. At i5 Pxpi. rviolent itchlinn of fionlt side of right ankle, while walkin') on the stireec; tip of' onognue sore wbhile eatingcr. At 5:30 P.. a. hrd achilno )ain inl middle of' tbrearn.l; itching of wrists. LAt 6:30 P. rii. halld dl1 paill in miiddle of rioight forearm, returned at intervals dulling the evCenig. At 6:45 a- r ms PRO VlNG OFP DIOSCORETiI. 21 and hands n-umb; dizzy. At 7 P. mi. hard pain at head of right tibia, extendino into tile knee joint; belching of bitter tasting wind. At 1_0:45 P. Mr. belching of wind and pain in left klnee. At 11 r. r.T took 80 grains. November 22.-In inmorning moith bitter; aching pain at epigastriuln and left hypochondrium; severe pain in first joint of right thumb; deep and dry coullh in the moninigo At 8:30 A. xr. dull pain thlrough right scapuila and lung; faint pain at the rnlibilicus, extendinog to epiastlrium; hardc pain in the bones of iright leg, 1belowX the knee. At 8.. pa)iln in filrst joint of right thnruib; hard, grinding pain in left elbow. At 9 A. rt. pain in fi-st joint of right thllumbl continues. At 10 -. i. sh arp pain in ri-ght lulimo; sharp, diggoing:)ain in left temnple; lhad, griiling pain in first joint in rigit thull b; pain in bones of left fotrearm. At 3. P. r. hal'rd pain in riglt arm between elbows andcl shoulder. At 5 r. ir. pain in the iioght thilumb; pain in the left scapula, thronogh the lung; dull, hard pain in left luinbar re'eioll; diggin pain ill te left hypoehon drimill; pain in the left left tirm below the elbow; Ihal, aching painl in light lunc, and in rihlit knee; durlingo aftelrnoon pain in penis aiid left testicle. At?7 P. Ar. took 80 grains; during' the evenin', belchinig of bitter, sour wind. At 10:45 P. ixr. wvealkness of rilht ktnee; vhen walking am dizzy and inclined to oo to the iiollt; in eveningo pain and sorenesis of left inguinal regrion and inlguinal,lands. November 23. —In imorning, on wakingi, month bitter; left knee weak and painfill. At 9:30 A. I. pail:l illn rio' lumbr; riegion; swelling, soreness and pain of left inguinal l Ylands. At 11 A. x. hard, sharp pain in region of onall bladdlerl; weakness of right knee. At 1 p. P. left knee paintifl on inside, ttave felt it for two or three clays; pain and soreness in left, axilla; hanids feel weak. At 3 P,. -i took 25 drops of the 4th dilution. At 5 Jxo,r. violent itchingf of left ankle when xwalkinl; clttin pain in left lugo.'At 2:30 pain in le-t forealrmi. At 4 1.. iscitaro-e of bright red blood fromi left nostril, followecd by one d-acik clot antd spitting of'X blood. At 7 P. ar. ptil iti fiist joint of left tllumb. At 7:30 p. xr. pain in bones of both i folreaLis; puling pain in the occiput; pain ili il'St joint of right tlhumb. \t 8. r. Ii sharp, deep senated pain belhitll right e:ar. At 9. rI lioring, achin-l )Lin in iriht little toe; corn oi: second toe of left foot verxy painfll and is sore; cutdilin pain ill left, seap)Il.a; pain in left (reat toe; lett ingouinal reg'ion very'sore; very' slhar1p seve1re pain in rigiht little toe; relieved by pressure; hardi pun ill n iddle of right t;ibia; p in in i idldle of letl ulna; pa;in in left, knee, as if out of joint, and could not ulove it, but is relieved by motion; diill painl in epi'astriurm; rio'lit knee wea-lk ad(:l painfil; sharp pain ill regiion of liver, thlolluol to ba.lek; pullillg pain iil left occiput, causi1n a,1 stupid sensation; hard, siiairp p;ain in rihlit temple; pain iln )back and lit llt side of th roat, ca.uslingr a chokinir sesllsation; trermbling, vitii fitint feelinl:a:t stoniacli; pain in righilt 22 PROVING O. DIOSCOREIN. elbow, then right knee; sore-nes so- left side of nose better, but sore on top and right side At':30 P. ir. very sharp, darting pain in left temple; hard,'-!Ki,,: t rain in both temples; sharp pain in right hand; achin.,!i:~i in left scapula, through the lung; pain in middle of left hum~:us, quite sharp; belching of wind, slightly bitter, causing;- or accompanied by shuddering; left ingninal region quite sore; sharp, darting pain in rectum; itching of various parts of the body and limbs; hard pain in right elbow; strong smelling perspiration on scrotum and pubes, quite uncommon; dull pain in right lumbar region; chilly in a warm rooni; bad sick feeling at epigastrium, as of undigested food. At 10:45 P. ir. took 25 drops fourth dilution; pain in region of liver, and am chilly. November 24.-In morning nasty, sticky mouth; sharp pain in left hypochondrium; pulling pain in left occiput; pulling pain in righlt shoulder; faint feeling at epigastrium, partially relieved by raising wind. At 8 A. M. took 25 drops fourth dilution; discharge of very offensive flatulence from the bowels; one coming into the room, thought the gas was escaping; it had a coppery odor; after breakfast, head feels tight, as if squeezed; a dull, pressing pain in front of both ears; a dull, pressing pain in both temples, relieved at once by pressure; sharp pain in right thumb; pain in left popliteal space, hindering walking; pain in righit thigh; dull pain in liver, quite steady during the forenoon. At 9 A. ir. hard sharp pain in left ankle; at 10 A. M. dull pain in'head, left knee weak and paintiul; at 11 A. ri. pain in left popli. teal space, then in right knee, then right popliteal space; at 2:30 P. M. took 25 drops; at 3 P. r ilame pain in sacral region, hindering movement; have felt it sl;t'rttiv Ti)rseveral days; at 3:30 P. Mi. took 50 drops; at 4 P. M. pain: {eft hand; at 5 P. xf. pain in left knee; repeated sharp jerking:,eviis in left shoulder; aching pain in left hypochondriumrn, and f-x;it ftieling at stomach, with chills in tack, pain in right templi, si;; i pain in middle of left tibia, belching of acrid wind, with sb-.:.dering. At 8 P. AI. took 150 drops, tburth dilution. At 9 ). pr. sharp, tearing pain in left knee; distressing pain at epigais iriumn, relieved by raising sour, bitter wind; sharp pain in let't; t,iple, raising sour, bitter wind, with shuddering; burning at epigastrium; right knee very lame and stiff; weakness of right hand.; pain and distress at left hypocholndrium; sore pain in right popliteal space; eyes smart all the evening, right one worse; pain and lameness of sacral region; feel confuhsed; call things by wrong names; when I mean left leg or arm, I write it right arm or leg, and have to change it; continued belching of wind, tasting bitter and sour, with pain in epigastrium and left hypochondrium; both knees weak and painful. At 10:30 to 11 P. -M. distress in stomach and bowels, with raising of bitter wind; knees weak and. trembling. November 25.-In morning mouth tastes nasty and bitter; both eyes sinart; pain in both tenlporal regions; sharp pain behind PR OV INO 95_.i ~'._.OSCOREIN. 23 right ear; dull pain in front f J —; pain and soreness at piegastrium; sharp pain in lel-;-:,-:hondrium; sharp pain over right eye. At 8 A. rI. tooe::;:F: — ops fifth (ilution. At S:15 sharp pain in left knee; sll: i -::i in left shoulder joint; friequent sharp pains in right sI::V —::~; sonr stomach; belching of sour water; during forenoo p!u:<'nt pains ill ight knee; also, left shoulder, and sour stomln-:'"t 1:30 P.AL pain in right knee. At 2:30 P. u. took 50 drops. P;: -: c. Lr. frequent paiiis on top of left shoulder; quite sh1arp —:il3 in rig ht leg; acid stomach; belching of sour wind; lamv:i 4f lumbar and sacral regions. At 4:30 1,. Nr. took 50 drops. At 7 P. tr. hard pain in left knee. during evetning sharp pain in Ituntmbar region; pain in left knee; pressing pain in both templces; corn on second toe of left ioot quite painfulf; sharp pain in ell i-astziUm. and left hypoclhondriuin spasmodic action of lower jaw, bit my tongue several times during' the evelling, when I was neither talking or c11hewiln(g; shami.r1 pain in left side of chest aun( leit temple; distress at stomach; hard, aching pain in rectlum;.iirtcess at stomacal; had to unlfitsten my clothes, usually quitel loCle; pain in lrillt ankle. At 10:30 i'. r. belching of laroge (quiant tAies of windc with a feeling as if both temples were in a vice, occasional pulling, twisting pain in recteum. At 10:45 P. tI. too1 0) dr ops. Novemnber 26.0-Awoke wi\itt. bitter, sticky mouth; swallow ing caused nausea and shudcerS~:.^;' sharlp pain in niuscles of lunnbar region; sharp pain in left:- I felt as thoullh I could not move it; sharp pain on top o:i hl:oulderl; slharp pain in fi ont and behind bot}h ears; sha:r:: in center of left luno; hicd, pulling pain in back of neeS.-:;-d - on left side all the plsail except headache, are relieve:-.:'ion, but iiot as readily as at the conimencenent of the l-: conlstalnt desire to swa,llow, but it causes nausea; fireqtei, -: pains in regionl of heart, oir a few seconds at a time. A.:; r. took 50 drops. At 10:15 sharp pain in back side of - and in seapula extecndii, down inside of left arim; fee; easily troubled. At 9 A. Mx. sharp pain in region of heart —':.; Co the left of it; pa. in i lett shoulder; stool lihlit colored, I::II;::,-)0;-., white, and sliny; mnith sore. At 1 P. I. roof of m-outh sore; g urs on inside of fi'ont upper teeth swollen; pain in right leg below the knee, worse on the back side; pulling pain in right knee; also, knee laine and weak; sha'rp pain in center of' lriht lung,;, shp paini in right hip joint; left knee weak. and puainifl; hard, pullinng pain all day on topl of left shoulder, extencding to neck nd hed-l,. hd worse ait the attalelhmeut of the ste rnocleido riilastoi(leus u-llcle; pain in left luno,, parlallel with and at the side of the nipple',,in ii rilit hand; ashiar:- pailn n left hypocliondrilm, with a ni,,:., stabbing pain, thell a dull ache in left temple; dull, heavys o and soreness in le f-t iljniuilal region; arlio, paui in Iig' re;iolln At'7:80 i. taool! 50 d rops; fullness at, et-p 0:.:: lotthes feel tight; feel (liull and stupid; eyes smart, and.d.. stiff. tAt 9 P. s. took 100 241 PROVI-NG OF DIOSCOREIN. drops. At 9:30 sharp pain in left little finger; sharp pain over left eye; drsawing pain at angle of' jaw; left side teeth feel sore; feel tlred and langunid; still keep nmoving around the room, restless; sharp palin in left thumb; dull pain in front of right ear,'and shilrp pain over left eye at same time; sharp pain in left tibia, near tle ankle, which made me limp; then pain in right tibia; then in right hand. At 11:30 P. pr. pain in back; pain in epigastrim-; pail in left hand. - At 12, midnight, sharp pain in right shoulder; pain and soreness in right axilla, extending down the armn, agcravated by walking; sharp pain at epigastrium; sharp pain in right knee and ri ht elbow; both eyes smart, and feel as if dust or eye-lashes were in them. November 27. —In morning mrouth dry and sticky, roof of mouth quite sore; righlt knee paintiul, both knees weak; sharp pain in posterior portion of right luIln; nausea after eating; pain in right knee, riolt ankle, and right elbow; sharp pain in lumbar region, extending to the testicles; eves sore and smnart badly; eyelids feel stiff, eyes do not look sore. At 8:30 A.o L. sharp, squineilg pain in licir; sharl pain left temple; pain in left shoulder; dull, hard pain in right hip; rig'ht knee lame and sore; eyes sore, left one worse; soreness fromn left eye to left temple. At 1 P. xr. liardl shap) pain il left popliwteal region; a sharp paiu went friomn the left thioih to the top of' the head, like an eeleetric slhock, vwhile lyinog down after dinner the pain was so severe that it imade me jumnp ip; a sharp, darting pain in a r'ight upper molar tooth, (whiiCh had been filled several yea.irs,) as if I touched a bare nerve; pain in thle jaw near the teeth; soreness of the g'ums extending o to thle roof of the mouth; dull pain in the epigas' triulm, withl fililness; frequent shrpl) pain in the liver; very sharp pain in right upper molar toothl. At 4:45 P. lr. pain in middle of rigcht tibia whern walkingig on the street, which mnade nce limp anid thle bone seenied sore, then the pain extended to the left side of' the knee joint, at edge of patella, lasting some tinie, and made me quite lanme, then the pain moved to the lower portion of fibula, saine leg, but wasr not so sevee; but a hard aching pain. At 6 4-it. I. ore late fbeling of right leg below the knee and in front; viilent itching' of left foot; severe painl in fi'ont and left side of head, overm the eye. At 7. m. a hard, sharp pain behind the left ear; tlhe soreness of the inose is all on the right side, with a small swelling; the inside of both nostrils dry and sore; roof of' mouth sore and troublesome; bothl eyes smrart and quite sore; the left one oflten Iels as if there was dirt in iit; teiting of rectum; left corlier of mouth sore. At 10:30 ) P. xI. itching of left internail calc; sharl- pain oe:r left, eye; thle soreness in left groin is w0rsie, is iiore 1pl infi, t111(1 extends down into the thigh; rig'ht tihia quite sore tanid painl when walking, but not pain-ftiul to the touch; it is relieve d by pressure or contact. At 11:20 took 100 drops sixth decinial dilution. SNovcntber 28. —in mornling imouth sticky and bitter; pain at (pigaStriuli aId lefi iiypoClhondrium. At 8 A. ri. took 50 drops PRO VING OF DI)OSUCORFI. N. 2:5 sixth dilution; eyes sore and lashes stuclk together. At 1.0 A. -I. hard, aching pain in left palotid olancl. At ]'I k. -r. slharp pain on inside of left ankle; roof of mlouth alld o-uins quite sore; in af: ternoon pain in both parotids; discharlle ot very oflensive iatulence firont the bowels; eyes sore; lu(ad, so0e pail 01o illside of left knee; dull pain in right knee; hrd pain oil top of' lelft shollulder; very sharp pain in left sidle oft back, tcat tentl t ib, very sudden; made me jup.]) At S. -it. hard pain in.l left t el))!e, relieved by pressupre, but it produces lieat in tihe left ilostrlil; after the pain a sensation of pressure; itchlin' every e;veninii over tlte lower portion of right sciapul; knees weak when wi:alkingl; darting pain behind left ear; sorllness of stomach; pain ill right leo, above the knee; clarting pain in right iand, feels ias if spr1 aixned; stabbing pain in livrx; bulining at stomach; Iboth pilrotid o'lands sore, with pain extending to tble throat; shar, l} pain in riglht wrist; dull pain in left hip; blunillng at stonlnac l cotinues; tongue sore on right side; feel languid; pain ill rihllt hip, extending down foiont side of leY, near to the knee; lil-ve to limp whenr walking; inllinled to iraise wind, but c(allnot; palil iln back of' neck. At 10 P. took 7i cllops; botlh eyes sore(, fbel as if there were sticks in themn; sharp pailn in rinlht popliteal space, which hinders wsalking; dull pain ini saceal regiorll. November 29.In II or:ling, bitter taste ill mInoutil; shaiiLp pain in right temple; dulll pain in left temple; dull pain ill middle of' bones of fobre-arm; pain in rihllt anllkle; mouth sore; sharp pain through the center of right lungI. At,. Atr. sharp pain throughl left lung, near the nipple; sharp pali in region of Leart; had to stop when walkinlg; pain on inside of tleft iitt t ee 3 %. xtr. sharp pain at lower portion of left scapula, throug li thle lungl-; stomach and bowels feel full, with dull pain during thle evening; pain il:i both temples; tongue sore. At 12, midni(lit, took 100 drops in one gill of twater; after going to bed, eyes sinlrl't So b)'idly thlllt it feels as if hot air was cominlg out of them ad p;ll a 1 ssillg OVe' the ftice; restless, cannot go to sleep. November 30O.In morninm, rmouthl bitter-; i);l)ill ill both ten1ples; discharge of' dreadfully offensive IT.Ittlence fiom tiue bowels, with urgent desire fboi stool; offensive 1stool; burnliin at stollach1; dull pail in back of neck; during tlhe mloring, tour offellsi.ve stools, each one inoe slimy thall the priececling one, micd lore stra.ining, perhtaps aglgravttetl by dinlliilli prtl' of a rlass of (slightly fermented) new cider the prlevious evei l nii, thloumgh I am:n confident the cider alone woutld not I-xave caused it; palins in bones of the hands left one worse; painl in left ara, left leg, and left fboot; fiequent simarp pains inl light lung, one illnchl blow the nipple; pain in right temple, extending to the anole of jaw at tinceS, sharp at others, a dull, squeezing pain; pain in fioont of hleac and temples, as if liftecd up; dull pain in left hip; also, in hleel and sole of' foot; fiequent hard, dull pain in left " tendo Achilles." At 8 1p. Pr, sevxerle gliudinlo pain onl insidle of left Inee; pain in 0 26 PR O VI.NG OF DIOSCOREIN. right lung, one inch below the nipple; it feels:is if it w\)ould arrest breathing, but is not aggravated by a deep 1 inl sp'vlamtion, but gives an inclination to cough; both eyes smart; eyes feel as if some large simooth substance was in them; dull pain in right temple; dull pain in right elbow; pain in first joint of right thumb, at first dull, gradually growing sharper; pa.in and soreness of left axilla; feel dull and cross; desire to be alone; do not einjoy society; am usually quite fond of the society of ladies, but now they seem repulsive; sexual desire sadly diminished; itching over 1right slhoulder blade; pa in il riglit lung, just above the nipple; both eyes snmart. At 10:20 v. Ai. took 150 drops sixth dilution; restless, cannot sleep; multitude of dreamls. December 1.-In imorning mouth bitter, sticky and c(lammny, tongue slightly coated; severe pain in lower part of bowels great desire for stool, driving me out of bed; quite loose stool one and one -lhalf hour later another small, light colored stool, with much straining; during forenoon occasional pains in bones. At 2 r. ir. desire for stool, with faint burning pain i recturn; feel dull and stupid, went to sleep in my room, a very uncommon occurrence, awoke with very bitter mouth; pain in bowels and ect;urm; desire -fobr stool, slimy, stool; during evening, belching of wind and bitter mouth, the bitter seems to be worse oi the sides of the tongue, and back part of it; feel dull and stupid, but feel well in the forenoon. At 8 P. Ar. mouth dry and bitter; pain in both hypochondria. At 9 P. ii. took 5 ldrops. On (omilg to bed could not go to sleep as usual; had pains in joints and bonles. At 1:30 A. r\. was called up; hard pains ill bones of legs an'ud was chilly, with very bitter mouth. On going to bed at 3 A.. Al., could not go to sleep, was quite restless. December 2.-Awoke in the morning with mouth ely bi;tter alnd sticky; paili in both temples; sore pain at angle of jayw left, side; throat seems sore but is lnot; pain in both shouldcers, left one worse; pain in left elbow; pain inl ighlt lung then the left; sharp pain in thle liver; heavy feelingT at stomach as of' udiogested foodl; sorenless of let( hypochonldrium; soreness and pain in rigllt lumbar region; pain in right hip; pail in left thigh; right knee is weak and paintifl; pa i in right tendo- Achilles; sharp, pu-lling pain in left lband. At I1. I r. hIard pl.in in right leg, near the lknee, back side. At 2:)0. Pr. dark, slimy, offensive stool. At (; 1:. xI:. stomach bloated so I had to unfhstenl my clothes. Atl 7:30 r. ii. sharp pain in ball of right eye; both sides of tongue so~,le near back Imolar teeth; roof of mouth and tip of tongue sore; itching over right scapula every eveninlg; immedicately after lying dcowl in bed, a clard lt not very slharp pain in left lypochondrinm, aggravated by lying 0 on rih,'t sicde, but not eia ioe(-l by turning to left. December 3. —Had a restless, dreamy night; in the mnorning mouth bitter, sore ancl clammy; sharp, deep pain at lower PRF to VINGr OF DIOSi'OS(C0ORI iN 27 portion of' left scapula, followed by a shalrp pain throug hcentre of riogit lung; severe pain in both temples and front part of head; I-oth knees weak, rig'ht knee painful; dliawingo pain through both shoulders; finger nails very brittle. A-t 1]. Ar. sharp pain in right knee, the knlee is weak and lame; pain in left side of head, both in fiont and behind the eat'; distress at stomach all tlhe o benoon; dull pain in both temples after dinner; itching over) both scapultex, worse on right. At 9 P1. Mr. sharp pain in center of rigoht lunr,; inside of ilostrils sore; lips sore; knees weak and painful; pain in calf of right leg; both eyes weak and sore and sinart badly; eyelids seem stiff; dull pain in left hypochondrium when lying upon the left side; dull pain in the epigastrium and right hypochondrium. At 11 P. rI. hard, aching pain just below the outer angle of right eye; dull pain in left shoulder; mouth sore; after retiring restless and uneasy; left inguinal region sore and painful; pain in both knees, right elbow, and left shoulderl; pain in liver, worse when lying on right side. At 1 A. )rr. mouth bitter, dry and sore; saliva runs out of the inouth when asleep; sharp pain in middle of right fibula; stomach reels faint and bad; dull pain in front of head; jumpinlg, darting pain in corns on 2nd toes of both feet; dull pain in both hands; lame pain at head of right fibula; sharp pain in right lung and left knee; left groin sore and painful; eyes sore; dull pain in epigastrium and both hypochondria. December 4. — Mouth bitter and sore; pain;in stomach; fiequent pains in joints. At 3 1,. in. hard pain in right knee and ankle. At 5 P. ir. pain in left shoulder; pain in right hand. At 8 P. iNr. pain in left hand; frequent pains in right hand; frequent dull, pressing pains in temples; for several days, feeling in the stomach as if distressed by food, much worse to - day; bad, distressed feeling at stomach after eating only a little; stomach bloated, have to unfasten my clothes. At 10 P. irn. stomach has been distressed all the evening; frequent sharp pains darting firom one part of the body to another; hard, aching pain at the middle of left fibula; restless, dreamy sleep. Decemnber 5.-In: morning, mouth bitter, dry and sore; eyes sore, right one stuck together, for the first time in my life or remembrance. At 7 A. AI. sharp pain in right lung, just below the nipple; sharp pain in left lung, just below the axilla; dull pain in back of neck. At 10 A. nL. sharp pain in right knee; frequent sharp pains in center of right lung. At I p. i-r. sharp pain in back, at lower portion of left scapula; aching pain at top of left shoulder; stomlach feels raw and bad; frequent hard aching pains at the upper portion of left fibula. At 4 P. rn. hard aching pain in right leg, just ab)ove the popliteal space; fiequent hard pains in left elbow; pain in rigiht elbow; fiequent sharp pains in various parts of the body. At 7 uP. in. sharp pain in left lumbar region, that pulled me over backwards, and made me groan out loud; a, dull, numb pain extends down fr'om left elbow towards the wrlist, 28 PRO YV-TATf OF D~OWSUOfVE.~' alono' thle uIna; left shoulder is lame and painful; it seemns ais if I allnot moi)e it, but it is relieved by movement; -idull, grinding pain in left lower jaw, between teeth and angle of jaw; eyes s[nart s svee, sharp, pulling pain on inside of right elbow; jumlnpinllo darting pain at angle of jaw, rigllt side; pricking pain it left hypoehondr'iun dull, aching pain at epigastrium; drawi-ll paiil in upper portion of left fibula; pain in top of left shoullel, so severe I cannot sit still; chloroform applied; gave relief; but it soon returned; the pain extends up into the neck; much itching over the right scapula; hands feel numb, left one worse; belehfinog of wind; bad smell in nose, as from a bilious dysentery patient, every day; rioht knee weak and paintful when -walking; sharp pain in left luni, below and to the left of the nipple; sharp pain in lower portion of right lung; sharp plain at epigastriim; painl and soreness in left axilla; leftngininal region. sore and painful. I)ecembei r 6.-I-n mnorlning, mouth dry and bitter. At 7 A. Af. pail in both temples, left one worse; pulling pain in occiput;.burning pain behind top of sternum; sharp pain in lower portion of left lun,; dlrawing pain in right lung; hard, dull pain in region of gall bladder; left inguinal reoion sore and painful; sharp, drawlwillon pain in left luimbar region; rioght knee painful; sharp, drawing pain in riYght shoulder, extending to the back portion of tie lung; left side of tongue sore; left shoulder painfil. At S i-. I. both knees weak and lame. At 12 ir. severe burning itching oerl rioht scapulla. At 2 p. ur. lame pain ill upper portion of left tibia; dull pain firoi the occiput through to the front part ot the head; sharp pain in center of right lung. At 3 P. mr. pain in fronlt lowel teethl. At 4 P. M. locd riinging in ears, worse in right. At 6 r.:r. pain in lower back teeth, left side, extending to angle of jaw and pariotid gland; pain in upper front teeth; troublesome itching all the evening over the right scapula, even to soreness; pain in right knee; pain ill both knees; eyes smart; sharp, pricking pain in region of heart; bad, falnt feeling at epigastrium;,dull leadache; pulling pain in left tonsil; hard pain at middle of left humerus. Deceniber 7. —In mornino, month dry and bitter; dull pain in left occipital region; sharp pain in right temple and front of the head; irritation of throat, left side, extending to the ear and down thle pharynx, causing cough; stomach feels badly, sore and -faint; sharp pain in left elbow; dull, hard pain in right knee. At 9 A. ri. haid pain in left knee, at head of fibula; sharp pain in lower portion of right lung; sharp pain in right knee and elbow; shap1 pain in rliht temple when eating dinner. At 1 P. -Ar. draw\in(g pulling pain in cervicle vertebra; sharp pain in right llmnbar region, pullinig me over backwards and to the right; slarp pain in left knee, outside; sharp pain in left lumnbar region, pulling me over back'and to the left. At 7 P. 2r. sharp, darting pa in ilower portioi of left lung; stomach feels full and P R VING OF DIOSCOCORE.[. 2-)9!) distressed; itching over right scapula; right knee lame and painf-l. At S i. Ar. stomach distressed and bloated, had to un-'asten my clothee; shlarp pain in left hypochondrium. At 9 P. Nr. burning and itchinog over left scapula; drawing pain in right knee; sharp pain in lower portion of left lunog; dull pain in left thuimb;;grindiill I pain in left elbow; dull pain in left hand; feel dull; desire to Ie alone, conversation is troublesome; lnmbar rcgion lamlle an( stiff; violent itching over right scapula, slight over the left; fi'equent pains through left lung; knees weak and painful; dull paiin at middle of sternum; tip of tongue sore; hard paini in right hand. At 10 P. Mr. sha-rp, wringing pain inl left parotid glandc; drawing pain in right leg above the popliteal space. At 10:30 P. -r. sharp, darting pain over left eye; pulling pain in left lunlbar region; hard, aching pain in left hypochondriun; hard, sharp, twisting pain just below the left axilla; cramp like pain at the epl gastriunm, all relieved by motion; eyes Aweak. -December 8.-Tn morning mouth bitter and clamnmy; tongue coated brown, and is sore on tip; dull pain in head, both fiont and temporal reoion; stomach feels bad and faint; dull, twisting, sinking pain in region of gall bladder; right knee weak and lame; hard, twisting pain at first joint of right thumb; every dlay bloody taste in mouth; dull pain in region of liver, aggravated by inhalation, relieved by exhalation; left elbow lame and stiff; dull pain in temporal region,'both sides; grinding pain iin elbow joint; constant smell in nose, as from bilious fever patients; dull pain in left hypochondrium; dull pain in lower poition of left lung, back side; tongue feels as if burnt. At 1 p. *. achin g pain in right elbow; sharp pain over right eye, extending to the occipital region; lame pain in left elbow, alternating with pains in the knees; both knees weak. At 5 p.:r. dull pain in back portion of left lung. At 6 P. M. dull pain through right hlng; frequent aching pains in knees and elbows; sudden sharp cramlping pami in right lung, just below the nipple, arrestinog motion and breathing for a few seconds; aching pain in left little finger; pulling pain in right popliteal space; dull pai in epigastrium and left hypoehlondrium. At 8 r. ii. pain in left elbow. At 9 p. at. pain in right ankle; outside soreness over right seapula; distress at stomach; dull pain in right temple; drawing pain in left el bow; hard pain in left temlple; eyes smart. December 9.-In morning mnouth clammy and bitter, tongue coated slightly brown; sharp pain in left knee; dull pain in left hypochondrium; drawing pain in left hland; dull pain in both temples; drawing pain. in right knee; both ankles lame and painfl. At 9 A. M. very sharp pain in epigastriunm, causincg nie to bend over; sharp pai n in ight lung; sharp pain in inside of left knee; left wrist lame and painful; pain extending up left leg, from the knee. At 10 A. -r. sharp pain at right side of epigastrium. At 1.1 A. ro sbharp pain in left knee. At 1 2 ar. hard pain P0 PRO VING OF DIOSC'OREVI. in back and central portion of right Ilung; distress in left lung, near the heart. At 2 r. ~i. hard, but not very sharp pain in the back portion of left lung near the lower portion of the scapula: At 4 P. iM. pain in left knee; pain in right knee; slharp, darting pain in region of heart, arresting breatlin,; distess andcl faint feeling at stomach; three light colored, loose, slimy stools; continued desire for stool, stomach seems swollen, have to unifLsten my clothes; dull grinding pain in left elbow, as if out of joint; pain in right forearm; sharp pain in region of' heart, arresting breathing. At 10:3)0 P. -i. continued violent itching' over right scapula; occasional itching over left scapula; itching of right, internal ear; small balls of wax drop out of' tle right ear, almost every day. At 1.1:. ar. sharp, darting pain in left hypochondrium; twisting pain in fi'ont of left ear, causing a nllmbt sensation of the head; after ogoing to bed, severe aching pain in fiont of right ear, lasting soume time. At 11 P. Mr. sharp pain in the epigastriumn; dull, achling pain in liver, worse on lying on right side. December 10.-At 7 A. AM. sharp pain in epigastrium; constant distress at stomach, with fiequent very sharp pains. In morning mouth bitter, dry and rough, pain in left hand. At 1 P. Mi. discharge of very offensive flatulence from the bowels; no stool till afternoon, very uncommon; during the afternoon fiequent severe but not very sharp pains between the third and fburth metacarpal bones of the left hand. At 4 p. har. hard pain through top of left lung. At 8 P. P. dull pain behind top of sternum. At 9 P. AI. dull pain through top of right lung; tongue sore; lips burn; constant dull pain at the epigastrium. At 9:30 N. ir. hard pain in left elbow. At 10 p.:r. grinding pain in right knee, at lower portion of the patella; stomach seems bloated, have to unfasten my clothes; dull pain in temples; irritation ot throat, with inclination to cough; eyes smart; dull pain at epiogastrium, and both lungs aggravated by a deep inspiration, and worse behind sternum. December 11. —Mouth and tongue dry and bitter; bad smell in nose; stomach feels badly. At 2 P. rI. pain in upper portion of left lung. At 4 1,. Ar. pain in the upper portion of the right lung; the old hemorrhoidal tumor hatd nearly all disappeared. but to-day it returned, and is quite sore. At 10 P. ir. both knees quite weak; dull pain in head; constant bad smell in nose, like bilious fever patients; lumbar and sacral regions -very lamne, worse oin stooping; dull pain in both tenmples, worse in right. At 11 p. ~I. took 500 drops sth dilutionl. December 12.-At 5 A.,AI. mouth bitter and clammy; bad smell in nose; discharge of large quantities of flatulence from the bowels. At 7 v. T. hard, aching pain in left knee, commencing in back side and extendinog through to the front; seems as if I could not move the joinlt,; then pain in right knee; then in left again; griping in lowel part of bowels; pain in both knees; pain in PRO OV1NG OF DIOSCOREIN. 31 right hand; distress at stomach, and belching of large quantities of wind; dull pain in both sides of head; great desire for stool; dark, offensive stool; distress at stomach, as of undigested food, -vith occasional sharllp pains and heat in stomach; constant desire for stool. At 9 A. I.- another dark, offensive stool; pain in liver; distress at stonach; hemorrhoidal tumnor quite sore. At 12:Ir. nausea; sharp pain in liver; sharp pain in left hypochondrium; soreness on left side of nose returned; hemrorrhoidal tumor very sore; have to imove with care. At 3 p. ir-. another stool. At 5 P. r-. sharlp )pain extending firom the painful hemorrhoidal tumor to the regioni of the liver; constant distress at stomach; have to unfaisten my clothing; belching of' quite acrid wind; stomach burns and smarts, and is sore; almost constant passing of flatulence from the bowels, with loud rumbling in bowels, left side; dull pain in liver; sudden prickinig pain in rectuml; itching between the shouhller Mlades; darting pain in left temple. At 7 P. 2r. feet and legos to uknees feel nunmb and strange; sudden sharp pain at back part of left lung, near the centerl; burning in stomach al:nd snuartig al:t tllhlroat all the evening; sudden shocks of sharp pain in left temlple hard, aching pain in left fore-finger; burning in stomtlaic, exteanding all over the chest. At 10 P. ir. took 500 drops Sth (lilltioll, followed by dull pain in head. andc wringing pain ill left hypochoncllritul; then in epigastriuml; sharp pain at rnmbiliens; both eyes smart; dull, heavy ache at epigastrium; dull, heavy, cdistressed feeling in liver, in region of gall bladder, when lying onl the right side; knees weak and painful. December 13.-lIn morning mouth dry and h)itter; distress in stomLach alnd liver; back lame; violent itchinlg over both hips, extending down the legs, aggravated by getting cool; bad smell in nose; dark, offensive stool; pain liver; dull pain in back. At 12 i r. harLd pailn in upper posteior palrt of left lung. At 4 ip. iM. shal3rp pnlill ilt left lhypochondriinm. At 6 P. ri. pain in liver; burniat ill stoimaxll; pain in back of head; eyes and inside of' nostrils sma5rt; left side of tongue sore; in evening, pain in liver; sh;larp pnail in left hypochondriuim; sore pam in i upper portion of bothIt lungs; also, in balck side (, left lung; sourness and burning at; stonlil lIt (all the eveninog at tinles extending to the throat and roof of tlle mouth; severee, almost unbearable, itehing over right scapula,,vlithout any elrtption; itching' every day oln thighs and leo's woisec on undlresing or geotting chilly. At 10:45 P. ar. took 1,000 dlops 8tl- dilution, followed by a spasmodic closing of the jaws, and bitming the tongue; pain in liver wvhen in bed. l)ecembel 1-4.IX mloninTg outh dry and bitter; pain in center of' iilht lung'; discharge of very offensive flatulence friom the bowels: dark bilious, slightly costive stool; pain in liver; pain in left illuinl reogion; pain in left axilla; dull pain in the iight telple, it seelms to be over a large srf'ace oni the outside, but conecenlltrated to a small point internally; dull pain in the left t.emple; p, i in both inlguinal egions, extending to the testicles; 32 RPltO VlNCI OF DIOSCOREIN. acid stomach with burning; lischarge of' offensive flatulence from the bowels; violent itching on back, shoulders, and various parts of the body; htemorrhoidal tumlor quite sore all day; bad smell in nose all day, as if somnething in the nose; pain in bowels, as it a dia'llhca would come on; discharge of very offiensive flatulence fiom the bowels; dull pain in middle of fore arm. At 1 P. Mr. shiarp pain in left temple; nose dry and bad smell in it. At 11:15 1,. Ar. took 2,000 drops of' the 8th dilution; immediately belchingo of wind with shuddering and bitter taste in nImouth. Decemlber 15.-In the morning mouth very dry and bitter; tongue dry ald stiff; painl at epigastriunl; pain at the umbilicus; griping pain at hypogastrium as if a diarrhwea would come on; entirely relieved by passing small quantities of flatulence; urgent desire for stool, with small bilious stool, and pain in the bowels during stool; pain in the liver; sharp, cutting pain in the stomachb; very sudden pain in both spermatic cords, extending to the testicles; dull pain in the left leg above the knee; dull pain in right leg, below the knee; during the day and evening, violent iteling over the right and between the scapulhe. At 9 p. tr. took 3,000 drops, or about four fluid ounces of the 8th dilution, followed by hard aching pail in right hand; dull pain in the left temple; itch;ing of rectum; vwringing, twisting pain in the left hypochlondrium; dull, squeezing pain in front of both ears, extending to the angle of the jaws. DIecember 16.-In morning mouth and tongue very dry and bitter; gripingo pain in bowels, worse in lower portion; bilious, very offensive stool. At 1 P. ii. friequent, wringing pain in left inguinal region; violent itching of the rectum, cannot sit nor standl still, soreness of the hcmorrhloidal tumnor nearly all gone; knees weak and lame; little balls of wax drlop out of the right ear; lameness of lumbar and sacral region; tip of tongue sore. At 5 P. -,. severe itching betweenl the scaplulc; itching of the rectum; pain inl ight leg, below the knee; sharp pain in the left knee; dull pain in the right temnple; cligging painl at the angle of left jaw; hard burning at left lnt:iblar regrion; cra1nping pain in small of' the back; violent itching ovei both hlips and the right thigh; fiequent bad smell in nose as of bilious rinces. D)ecernber 1 I7.In lmorning nouth and tollgtue dry, bittelr and sore; dull griping pain in bowels; badl smell in lose; any of'en — sive sm1el remains a longI timne in the nose. At'7. M. stool morel natural, folloiwxed in a half hour by desire fol stool; griping pail in lower p-art of bowels, which goes off enti elv by the same kind of' pain ai)laring' at eligastriuLm, which remnains some time; sharp pain at epigastrium, aggravated by stooping, relieved by standing erect. At 8 A. r. another stool; dull, twisting pain in left ilypochondrin. At 10 A. ar. sharp pain in epigastrium; sharp pai ill left hypoehondrium. At 2 P. MI. itChinlg of rectum. At 7 P. i. hard lame pain in right knee; eyes smart and sore; dull, gyrindinio pain in stolnach, and bad stmeol. in nose; constant PROVING 1OF DI OSOREILV. 3.3 desire to pass flatulence from the bowels: eru:ctations of wind; dull pain in bones of left leg, below the knee; dull pain over left eye; sharp pain and Wkint feeling at reg'ion of heart; itching over right scapula; dull, grinding pain in left, elbow; eyes smart all the evening; bad smell in nose; sharp pain in region of gall bladder; awoke suddenly from sleep with hard, but slow, beating of the heart, shaking the chest. December 18.-In morning, mouth dry and bitter; dull pain in both temples; both knees weak and painful; distress at stomach; bowels feel full and distressed; left shloulder painfil; very bad smell in nose, like bilious faces; frequent sharp pains in region of heart. At 4 P. 3&. sharp pain in ri'ht lung, below and to the right of the nipple. At 5 r. M;. left knee lame and painfi l; had to limnp when walking; sharp pain in right lung. December 19. —In morning mouth dry and bitter, At 4 A. i. sharp pain in hypogastrium, relieved by dischargie of flatllence, followed by urgent desire for stool, dri1iving me out of bed; stool passed with a great deal of oirce, ftllowired by straiining. At 5 A. M. sharp pain in umbilicus; dull, sqiueeziing paii in botli temples, with nausea and chills, and mouth dly, but no thirst; desire:for stool. At 6 _.:N. niouth dr1y, pain in bowels, wNith desire for stool. At 6:30 A. AI.,pai in towelsn; ui'get desire foi stool; stool, with fbrcing, fbllo-wed bv stlrai'tinin and pain in hemorrloidal tumor.. At 7 A.. A constMnt chitll, l rilnding pain in bowels,.and desire for stool; chilly; dull hIeadacle inl both temples; soreness of lower portion of bowels; tolglle coated slightly brownA; dull pain in bone of right leg, above the k]nee; constant sharp pain in umbilicus an