STATE BOARD EXAMINATION QUESTIONS & ANSWERS €>f flottytate$ ana Ctoo Canafcian ptofottueg A PRACTICAL WORK, GIVING AUTHENTIC QUESTIONS AND AUTHORITATIVE ANSWERS THAT WILL PROVE HELPFUL IN PASSING STATE BOARD EXAMINA- TIONS. REPRINTED FROM THE MEDICAL RECORD. €l)ir& €&ition Revised and Greatly Enlarged NEW YORK WILLIAM WOOD & COMPANY MDCCCCX v<\ Copyright 1910 By WILLIAM WOOD & COMPANY First Edition, November, 1907 Second Printing, April, 1908 Second Edition, September, 1908 Third Edition, October, 1910 ©CLA275043 CONTENTS Pages Questions Answers Alabama 5 g Arizona 21 26 Arkansas 41 44 California 49 54 Colorado 71 75 Connecticut 91 94 Delaware 109 113 Florida 126 129 Georgia 140 143 Idaho 155 159 Illinois 176 181 Indiana 195 200 Kansas 217 221 Kentucky 232 236 Maryland 258 262 Massachusetts 276 280 Michigan 294 299 Minnesota 315 319 Mississippi 340 342 Missouri 352 356 Montana 371 373 Nebraska...- 386 389 Nevada 401 405 New Hampshire 417 420 New Jersey 429 435 New York 458 463 North Carolina 480 483 North Dakota 500 504 Ohio 518 522 Oklahoma 534 538 Oregon 552 557 Pennsylvania 581 584 South Carolina 597 602 South Dakota 617 621 Tennessee 638 641 Texas '. 650 655 Vermont 678 682 Virginia 698 703 Washington 722 727 West Virginia 743 747 Wisconsin 761 764 British Columbia 776 77& Ontario. 790 797 Requirements for Medical Licensure.... 818 Bulletin of Approaching Examinations . 819 MEDICAL RECORD. &iai* M&xtnl Wixtt ttatng Htmvba. STATE BOARD EXAMINATION QUESTIONS. Alabama State Board of Medical Examiners. ANATOMY. (For graduates of less than five years' standing.) 1. Describe the upper third of the femur. 2. Give the class of joint, the articulation, and ligaments of the shoulder joint. 3. Trace blood from the heart by way of the subclavian artery to the circle of Willis, naming the arteries uniting to form the circle. 4. Name the muscles of the anterior chest, and give origin and insertion of the largest one of them. 5. Name the main superficial venous trunks of the upper arm, describing one of them. 6. Describe the gall-bladder and the bile-ducts. 7. Describe the great sciatic nerve. 8. Describe the rectum. (For graduates of more than five years' standing.) 1. Name the bones of the lower extremity. 2. Name and locate the valves of the heart. 3. Describe in full the sartorius muscle. 4. Locate the spleen and describe its gross anatomy. 5. Describe in full the pulmonary veins. 6. Describe the contents in Scarpa's triangle and give their relations. 7. Name the lobes and ventricles of the brain. 8. Name the ligaments supporting the uterus and describe its blood supply. PHYSIOLOGY. 1. Explain the functions of the spinal cord. 2. What are the functions of the trifacial or fifth pair of cranial nerves? 3. What is meant by cell action? Give examples. 4. What are the supposed functions of the spleen? 5. What are the supposed functions of the thyroid gland? What symptoms sometimes follow its removal? 6. Explain the glycogenic function of the liver. 7. How is the equilibrium of the circulation of the blood maintained in the body? 8. What are the functions of the skin? CHEMISTRY. (Answer eight.) 1. What is the difference between analytic and synthetic methods in chemistry? Illustrate each. MEDICAL RECORD 2. Explain the reaction which occurs when the aqueous solutions of the two parts of a Seidlitz powder arc mixed. 3. Write the equations which show the reaction occurring when corrosive sublimate and potassium iodide in solution are brought together. 4. What is the essential element of all acids? Differenti- ate between hydracids and oxyacids? 5. Give a test for H 2 S0 4 when an adulterant in vinegar. 6. Give the technical names of (a) aqua regia, (b) oil of vitriol, (c) green vitriol, and the formula of one of them. 7. What is the chemical composition of ordinary alum? 8. Give the chemical reaction of (a) tears, (b) bile, (c) blood, (d) saliva, (e) milk, and state what salt causes acidity of urine. 9. Give a test for ferrous salts. 10. Explain the difference between a sulphate and a fulphite. Give an example of each. 11. Give tests for albumin and sugar in urine. 12. Describe a chemical test for blood. PHYSICAL DIAGNOSIS. 1. In what pathological conditions of the lungs is moder- ate dullness found; in what is absolute dullness found? 2. Give differential diagnosis between acute bronchitis and lobar pneumonia. 3. What are the principal points of difference between pleuritic friction sounds and bronchial rales. 4. Give the diagnostic signs of aortic aneurysm. 5. What are the conditions most favorable for the pro- duction of metallic tinkle? 6. Give the differential diagnosis between endocarditis and pericarditis. 7. Give the diagnostic symptoms of emphysema of the lungs. 8. Differentiate between aortic stenosis and mitral in- sufficiency. ETIOLOGY, PATHOLOGY, SYMPTOMATOLOGY, AND DIAGNOSIS. i. Give the etiology of cirrhosis of the liver. 2. Give the etiology of pyelitis. 3. Give the pathology of arterial sclerosis. 4. Give the symptoms and diagnosis of hookworm disease. 5. Give the differential diagnosis between pericarditis and acute pleurisy. 6. Give the pathology of cerebrospinal meningitis. 7. Give the etiology of erysipelas. 8. Give the pathology of pneumonia. OBSTETRICS. 1. What is meant by the inclined planes of the pelvis? 6 MEDICAL RECORD. 2. What are the forces by which the child is expelled? 3. Give operation for adherent placenta. 4. Give mechanism of left occipitoposterior position. 5. How would you manage a shoulder presentation? 6. Give 'causes and treatment of asphyxia in a new-born child. 7. How would you apply forceps at the inferior strait when the occiput has rotated to the pubic symphysis ? 8. Give the degrees of perineal laceration and manage- ment of each. GYNECOLOGY. 1. Give causes and treatment of hemorrhage of the uterus. 2. Give the cause and treatment of amenorrhea. 3. Define ectopic pregnancy and give varieties. 4. Give differential diagnosis between fluid and solid neo- plasms in the abdominal cavity. 5. Under what conditions and why would you prefer vaginal to abdominal hysterectomy? 6. Give symptoms of fibroid tumors of the uterus. 7. Give etiology of retrodisplacement of the uterus. 8. Describe the technique of a gynecologic examination. SURGERY. 1. Give general rules for the treatment of wounds. 2. Give symptoms and treatment of traumatic spreading gangrene. 3. Give general rules for the treatment of tubercular ab- scesses. 4. Give differential diagnosis between chancre and chan- croid. 5. Give treatment of a compound, comminuted fracture of the femur. 6. Give symptoms and treatment of subcoracoid disloca- tion of head of humerus. 7. Give symptoms and treatment of stone in the kidney. 8. Give treatment of penetrating gunshot wound of the abdomen. EYE, EAR, NOSE, AND THROAT. 1. Give symptoms and management of acute catarrhal conjunctivitis. 2. Give the symptoms, dangers, and management of gon- orrheal ophthalmia in the adult and in the new-born. 3. Give the management of ulcer of the cornea. 4. In what part of the ear does cerumen sometimes be- come impacted, and how diagnosed and treated? 5. What is the seat of acute suppurative otitis media, and what the symptoms, dangers, and management? 6. In the absence of the special instrument for the pur- MEDICAL RECORD. pose how would you arrest an alarming hemorrhage from the nose? 7. What is the most conclusive symptom of diphtheria, and how ascertained ? What is the most generally accepted treatment? Give in detail the method of administering the treatment, and the dose. 8. Name three instances in which intubation of the larynx would be indicated. Name three in which laryngotomy or laryngotracheotomy would be required, and describe the operation. HYGIENE AND MEDICAL JURISPRUDENCE. 1. What is the period of incubation of smallpox? Of measles? Give the differential diagnosis between these two diseases. 2. What is immunity? What susceptibility? 3. How is typhoid fever disseminated! Give the hygienic management of a case. 4. Describe briefly the proper location and construction of a school building. 5. Define malpractice. 6. What are illusions? Delusions? 7. Give the differential diagnosis between strychnine poi- soning and tetanic convulsions. 8. What are the symptoms of acute poisoning from coal tar derivatives? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Alabama State Board of Medical Examiners. ANATOMY. (For graduates of less than five years' standing.) 1. See Cunningham's ''Anatomy" (1909), page 223; or Gray's "Anatomy" (1908), page 223. 2. The shoulder joint is an enarthrodial variety of a diarthrosis ; it is formed by the head of the humerus being received into the glenoid cavity of the scapula; the liga- ments are: Glenoid, capsular, coraco-humeral, and trans- verse humeral. 3. Heart, aorta (innominate, on right side only), sub- clavian, vertebral, basilar ; then to posterior cerebral (which is part of Circle of Willis). This circle is formed: In front by the two anterior cerebral arteries (branches of the internal carotid), which are connected by the anterior communicating artery; behind, by the two posterior cere- brals (branches of the basilar artery), which are connected to the internal carotid on each side by the posterior com- municating artery. 8 MEDICAL RECORD. 4. Muscles of anterior chest are: Pectoralis major, pec- toralis minor, and subclavius. The largest of these is the pectoralis major. Origin: Anterior surface of inner half of clavicle, anterior surface of sternum, from the carti- lages of the second to sixth ribs, and from the aponeurosis of the external oblique of the abdomen. Insertion: Into the outer bicipital ridge of the humerus. 5. See Cunningham's "Anatomy" (1909), page 891; or Gray's "Anatomy" (1908), page 745. 6. The gall-bladder and bile-ducts. The gall-bladder is a conical bag placed in a fossa on the under surface of the right lobe of the liver. Its upper surface is attached to the liver, and its fundus and posterior surfaces are in- vested by peritoneum reflected from the adjacent surface of the liver. The body is in relation in front with the liver, and behind with the first part of duodenum, the pylorus, and the hepatic flexure of colon. The fundus is in contact with the parietes opposite the ninth right costal cartilage. The hepatic duct, formed by union of ducts from right and left lobes, issues from the liver at the bottom of the transverse fissure. It passes downward and to the right in the layers of gastrohepatic omentum, having the vena porta behind and the hepatic artery on the left. It joins the cystic duct, the two forming the common bile-duct. The cystic duct passes from the neck to the gall-bladder downward, backward, and to the left, to join the preceding. The ductus communis choledochus or common bile-duct is the result of the union of the hepatic and cystic ducts. It passes behind the first part of the duodenum, in front of the vena portse, with the hepatic artery on the left, be- tween the layers of the gastrohepatic omentum, and, pass- ing between the pancreas and second part of the duodenum, enters the small intestine obliquely a little below the middle of the descending part of the duodenum by an opening common to it and the pancreatic duct. — (From Aids to Anatomy.) 7. See Cunningham's "Anatomy" (1909), page 648; or Gray's Anatomy" (1908), page 1030. 8. See Cunningham's "Anatomy" (1909), page 1087; 01 Gray's "anatomy" (1908), page 1320. (For graduates of more than five years' standing.) 1. Os innominatum (ilium, ischium, pubis), femur, pa- tella, tibia, fibula, os calcis, astragalus, cuboid, scaphoid, three cuneiforms, five metatarsals, and fourteen phalanges. 2. In the right auricle are the Eustachian and coronary valves^ the former is situated between the anterior margin of the inferior vena cava and the c.uriculo-ventricular ori- MEDICAL RECORD. fice. In the right ventricle are the tricuspid and semilunar valves. In the left ventricle are the mitral and semilunar valves. Aortic valves, behind the third intercostal space, close to the left side of the sternum. Pulmonary valves, in front of the aortic, behind the junction of the third rib, on the left side, with the sternum. Tricuspid valves, behind the middle of the sternum, about the level of the fourth costal cartilage. Mitral valves, behind the third intercostal space, about one inch to the left of the sternum. 3. See Cunningham's "Anatomy" (1909), page 356; or Gray's "Anatomy" (1908;, page 518. 4. The spleen is situated in the back part of the left hypo- chondriac and epigastric regions, being covered by the ninth, tenth, and eleventh ribs, on the left side. It is of an oblong, flattened form, the external surface being con- vex ; on the inner surface is a vertical ridge dividing it into two parts, the posterior of which is applied to the outer surface of the left kidney, while the anterior one receives the tail of the pancreas and lies against the cardiac end of the stomach. Near this ridge is a fissure, the hilum, where the vessels enter. The anterior border is notched and the lower end is pointed and rests on the costocolic ligament, situated in the left hypochondriac region. It is covered by peritoneum, except at the hilum, where it passes forward and inward in a double line enclosing the vessels, as the gastrosplenic omentum, to the fundus of the stomach. It usually measures 5 by 3 by 1 or 1^ inches, and weighs about 7 ounces. — (From Aids to Anatomy.) 5. See Cunningham's "Anatomy" (1909), page 870; or Gray's "Anatomy" (1908), page 723. 6. Contents: The femoral vessels pass from about the center of the base to the apex, the artery being on the outer side of the vein; the artery gives off the superficial and profunda branches, and the vein receives the deep femoral and internal saphenous; the anterior crural nerve lies to the outer side of the femoral artery; the external cutaneous nerve is still further external, lying in the outer corner of the space; just to the outer side of the femoral artery, and in the sheath with it, is the crural branch of the genitocrural nerve. At the apex the vein (which at the base was internal to the artery) lies behind the artery. The triangle also contains fat and lymphatics. 7. Lobes of brain: Frontal, parietal, occipital, temporal, central (or island of Reil), limbic, olfactory, cuneate, orbi- tal, precentral, postcentral, quadrate. Ventricles: Two lateral, third, fourth, and fifth. 8. Ligaments of uterus: Anterior, posterior, two broad (or lateral), two sacrouterine, and two round ligaments. Blood supply: Uterine and ovarian arteries and veins of same name. 10 MEDICAL RECORD PHYSIOLOGY. i. The functions of the spinal cord are: (i) The con- duction of nerve impulses; (2) reflex action; (3) co- ordination ; it also contains special centers which preside over definite functions. In the spinal cord: (a) The white substance simply con- ducts nerve impulses; (b) the gray substance contains groups of cells which act as centers for and distributors of nerve impulses, and are also concerned in reflexes; (c) the anterior cornua have a motor and trophic function; (d) the posterior cornua are sensory. 2. The functions of the fifth cranial nerve. First ophthalmic branch supplies sensation to conjunctiva and skin of upper eyelid, cornea, skin of forehead and nose, lachrymal glands, mucous membrane of nose. Second, or superior maxillary branch, supplies sensation to skin and conjunctiva of lower lid, nose, cheek, upper lip, upper teeth and alveolar processes, and palate. Third, or inferior maxillary branch, supplies sensation to external auditory meatus, side of head, mucous membrane of mouth, anterior two-thirds of tongue, lower teeth, lower lip, and skin of the lower part of the face. This branch, in addition, sup- plies motion to the muscles of mastication (masseter, tem- poral, external pterygoid, internal pterygoid), also to mylo- hyoid and anterior belly of digastric. 3. By cell action is meant the function of cells, such as power of movement, of growth, of ingestion, of egestion, of reproduction, of secretion, of response to various stimuli. 4. The function of the spleen: The following theories have been held: (1) It is a source of production of the white blood corpuscles ; (2) it is a source of production of the red blood corpuscles during fetal life: (3) it is a place where the red blood corpuscles are destroyed; (4) uric acid is produced in the spleen; (5) an enzyme is pro- duced in the spleen and is carried by the blood to the pan- creas, where it converts the trypsinogen into trypsin. 5. The function of the thyroid is not definitely settled; (1) it has some trophic function, regulating oxidation in the body, and it is supposed to have also a special influence on the vasomotor nerves, the skin, the bones, and on the sexual functions; (2) it is supposed to antagonize toxic substances, and (3) it produces an internal secretion. Removal of the thyroid gland causes mental and bodily dullness and apathy, tremors, twitchings, overgrowth of the connective tissues, and development of fat; the hairs fall out and the patient becomes unwieldy and clumsy in II MEDICAL RECORD. both body and mind. The complete removal causes death in most animals, and it is not considered justifiable in man. 6. Glycogen is chiefly formed from the carbohydrates. The liver cells act upon the dextrose into which the carbo- hydrates have been converted by the action of the ptyalin and amylopsin of the digestive juices. This may occur by a simple process of dehydration : C3H12U6 — H2O = CetlioOs But the precise process by which it occurs in the liver cells is not known. At a subsequent period the glycogen is transformed into dextrose and is returned to the circulation. Hence the blood of the hepatic veins contains more sugar than the blood of the arteries, and these latter more than the blood in the veins (except the hepatic). This is the generally accepted view, but it is denied by Pavy, and the whole sub- ject is in a state of uncertainty. 7. The circulation of the blood is regulated in (a) the arteries by: (1) The elasticity and tone of the arteries, (2) the force and frequency of the cardiac contractions, (3) the resistance in the capillaries; (b) in the capillaries it is regulated by (1) the action of the heart, (2) the action of the arteries ; (c) in the veins it is regulated by (1) the action of the heart, (2) aspiration of the thorax, (3) the contraction of the muscles, and (4) slightly by the valves in the veins. 8. The functions of the skin are : Protection, sense of touch, excretion, regulation of body temperature, absorp- tion, and respiration. CHEMISTRY. 1. Analytic methods consist in breaking up a compound into its elements or into simpler compounds, as by acting on a carbonate with an acid we get water and carbon dioxide : CaC0 3 + H 2 S0 4 = CaS0 4 + H 2 + C0 2 . Synthetic methods are the reverse of this, and consist in building up compounds out of simpler compounds or out of elements, as when 2H 2 -f- 2 = 2H2O. 2. The monosodic carbonate is decomposed by the tar- taric acid ; sodium tartrate remains in the solution, and the liberated C0 2 causes the effervescence. 3. HgCl 2 + 2KI = Hgl 2 + 2KCI. 4. Hydrogen is the essential element of all acids. Hydracids contain no oxygen; oxyacids contain oxygen as well as hydrogen. 5. Add cane sugar and evaporate; if the sugar turns black H 2 S0 4 is piesent. 12 MEDICAL RECORD. (a) Aqua regia. (b) Oil of vitriol. (c) Green vitriol. CHEMICAL NAME. Nitrohydrochloric acid. Sulphuric acid. Ferrous sulphate. FORMULA. HNO.+3HC1. H 2 SO*. FeS(X 7. Ordinary alum is aluminium ammonium sulphate. 8. They are all alkaline. The acidity of the urine is due to monosodic phosphate. 9. Ferrous salts, on the addition of solution of potassium hydroxide, give a greenish-white precipitate, changing to green and then to reddish-brown, soluble in hydrochloric acid, but insoluble in ammonium hydroxide. 10. A sulphate is a salt of sulphuric acid, and contains more oxygen than a sulphite, which is a salt of sulphurous acid: H 2 S0 3 CaS0 3 Sulphurous acid Calcium sulphite H 2 Sp 4 CaS0 4 Sulphuric acid Calcium sulphate 11. Test for albumin in the urine: "The urine must be perfectly clear. If not so, it is to be filtered, and if this does not render it transparent it is to be treated with a few drops of magnesia mixture and again filtered. The reaction is first observed. If it be acid, the urine is simply heated to near the boiling point. If the urine be neutral or alka- line^ it is rendered faintly acid by the addition of dilute acetic acid and heated. If albumin be present a coagulum is formed, varying in quantity from a faint cloudiness to entire solidification, according to the quantity of albumin present. The coagulum is not redissolved upon the addi- tion of HNOs." For sugar: Render the urine strongly alkaline by addi- tion of Na 2 C0 3 . Divide about 6 c.c. of the alkaline liquid in two test-tubes. To one test-tube add a very minute quantity of powdered subnitrate of bismuth; to the other as much powdered litharge. Boil the contents of both tubes. The presence of glucose is indicated by a dark or black color of the bismuth powder, the litharge retaining its natural color. 12. Chemical test for blood: Boil a fragment of dried blood with a drop of glacial acetic acid on a slide; on cooling, hemin crystals separate out. If the blood stain is not recent a crystal of sodium chloride should be added with the acetic acid. PHYSICAL DIAGNOSIS. 1. Moderate dullness is found in: Consolidation of lung (in phthisis, pneumonia, gangrene, tumors), collapse of 13 MEDICAL RECORD. lung, congestion of lung, thickened pleura. Absolute dull- ness is found in : Rydrothorax or pleurisy with effusion, empyema. 2. Acute bronchitis begins with coryza; soreness and tenderness may be behind the sternum ; pain may be caused by coughing ; expectoration is abundant ; dyspnea is in pro- portion to the extent of the disease; the pulse-respiration ratio is not altered; fever is slight or absent; various rales may be present; the condition is generally bilateral; ends by lysis. Lobar pneumonia begins with rigors, sometimes also with vomiting; pain on affected side; expectoration is rusty and tenacious; breathing is very rapid; the pulse- respiration ratio is much disturbed; there is considerable fever; crepitant rales are heard in first stage, also in third stage (rale redux) ; usually only one side is affected; ends by crisis. 3. Rales are produced within bronchi or lungs, while friction sounds occur in the pleura and do not pass away after coughing. The creaking or crackling pleuritic fric- tion is often mistaken for a crepitant rale, and Tyson gives the following distinguishing characteristics : The friction so and does not pass away after coughing, while the crepi- tant rale may do so; the friction sound is more superficial and localized, while the crepitant rale is deep and more diffuse; the friction sound has a to and fro movement during inspiration and expiration, while the crepitant rale is only heard at the end of inspiration; pleuritic friction sounds are generally heard in the axilla or side of the chest, while the crepitant rale is most frequently posterior, often at the base of the lung. — (From Gould and Pyle's Cyclo- pedia.) 4. See French's "Practice of Medicine" (1907), page 630; or Osier's "Practice of Medicine" (1909), page 857. 5. Pneumothorax, or cavity in the lung. 6. In endocarditis: The murmur is soft, not harsh; it is systolic or diastolic; it may be transmitted; it is heard loudest at definite points ; it is not followed by signs of effusion ; the apex beat may be strong. In Pericarditis: The murmur is harsh; is not in connec- tion with the heart sounds: is heard loudest at the base of the heart and over the precordium; is followed by (or accompanied with) signs of effusion; the apex beat is gen- erally feeble. 7. See French's "Practice of Medicine" (1907), page 681; or Osier's "Practice of Medicine" (1909), page 635. 8. See French's "Practice of Medicine" (1907), page 579; or Osier's "Practice of Medicine" (1909), pages 802 and 807. 14 MEDICAL RECORD. ETIOLOGY. PATHOLOGY, SYMPTOMATOLOGY.. AND DIAGNOSIS. 1. See French's "Practice of Medicine" (1907), page 824; or Osier's "Practice of Medicine" (1909), pages 556, 557, and 560. 2. See French's "Practice of Medicine" (1907), page 907; or Osier's "Practice of Medicine ' (1909), page 703. 3. See French's "Practice of Medicine" (1907), page 625; or Osier's "Practice of Medicine" (1909;, page 849. 4. See French's "Practice of Medicine" (1907), page 498; or Osier's "Practice of Medicine" (1909), page 45. 5. In pericarditis: The friction sound is not affected by the patient holding his breath ; the pulse is feeble ; the pain is slight and is not affected by respiration. In acute pleu- risy: The friction sound ceases when the patient holds his breath; the pulse is regular and strong; the pain is sharp and cutting, and is worse on inspiration. 6. See French's "Practice of Medicine" (1907), page 141; or Osier's "Practice of Medicine" (1909), page 159. 7. See French's "Practice of Medicine" (1907), page 218; or Osier's "Practice of Medicine" (1909), page 210. 8. See French's "Practice of Medicine" (1907), page 154; or Osier's "Practice of Medicine" (1909), page 170. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), pages 3 and 262. 2. Forces by which the child is expelled: (1) Uterine contractions; (2) contractions of the diaphragm; (3) con- tractions of the abdominal muscles. 3. See Williams' "Obstetrics" (1909), page 478; or Hirst's "Obstetrics" (1909), page 436. 4. See Williams' "Obstetrics" (1909), page 267; or Hirst's "Obstetrics" (1909), page 404. 5. In cases of shoulder presentation, if seen before labor, version should be performed to correct the mal- presentation ; in case of impaction a cesarean section is indicated ; sometimes decapitation or embryotomy has been performed, but a cesarean section is preferable. Cases of shoulder presentation have been known to terminate spon- taneously, but it is not advisable to rely on this possi- bility. 6. See Williams' "Obstetrics" (1909), page 846; or Hirst's "Obstetrics" (1909), page 939. 7. See Williams' "Obstetrics" (1909), page 403. 8. See Williams' "Obstetrics" (1909), page 325; or Hirst's "Obstetrics" (1909), pages 609 and 867. GYNECOLOGY. 1. The following (from Gould and Pyle's Cyclopedia of MEDICAL RECORD, Medicine and Surgery) is a useful classification of uterine hemorrhages, and also give the causes of the same: 1. Hemorrhages complicating pregnancy, labor, or the puerperium: A. Hemorrhages of pregnancy : Caused by (i) placenta praevia; (2) premature separation of a normally situated placenta; (3) apoplexy of the decidua or placenta. B. Hemorrhages of labor: Caused by (1) placenta praevia; (2) premature separation of a normally situated placenta; (3) relaxation of the uterus; (4) laceration of the cervix;- (5) rupture or inversion of the uterus. C. Hemorrhages of the puerperium: Caused by (1) re- tained secundines; (2) displaced uterus; (3) displaced thrombi; (4) fibroid tumors; (5) hypertrophied decidua; (6) carcinoma. II. Hemorrhages occurring in the non-pregnant woman: A. In virgins before the age of thirty: Caused by (1) uterine congestion, the result of cold or exposure; (2) endometritis; (3) polypi and fibroid tumors. B. In married women before the age of thirty: Caused by (1) subinvolution; (2) laceration of the cervix; (3) endometritis; (4) retrodisplacements of the uterus; (5) polypi and fibroid tumors. C. In women after the age of thirty: Caused by (1) carcinoma of the cervix; (2) carcinoma of the body of the uterus; (?) sarcoma of the uterus. The treatment depends on the cause. For details see any work on obstetrics or gynecology. 2. Amenorrhea may be due to : Absence or imperfect development of the generative organs; also to stenosis, obstructions, or atresia of the genital tract; also to oper- ative removal of the uterus c r its appendages. Other causative factors are: Acute infectious diseases, anemia, chlorosis, obesity, drug habits, alcoholism, overstudy, lack of exercise, exposure to cold, and various emotional causes. Pregnancy or lactation may be the cause. Treatment consists in : Removing or treating the cause. 3. Ectopic pregnancy is^ a pregnancy in which the product of conception is not inside the uterine cavity. Varieties: Tubal, ovarian, interstitial, abdominal. 4. "The consistency of a tumor is ascertained by palpa- ting it in all directions between the fingers of both hands and by tapping it to determine the absence or presence of fluctuation. The left hand is placed firmly over the abdo- men on one side of the tumor and the fingers of the other hand strike or tap the abdominal wall on the opposite side; if fluid is present a thrill or wave is detected. The fluctu- ation wave, however, may be absent in multilocular cysts and in tumors having thick, tense walls or viscid contents. The length and intensity of the thrill over different parts 16 MEDICAL RECORD. of an abdominal enlargement are of great diagnostic value in many instances. Thus, in ascites and unilocular cysts there is no variation in the character of the wave, whereas in a multilocular tumor it differs as to length and intensity over different parts of the growth. In obese womei. the fat contained in the belly walls causes false wave or thrill when the abdomen is tapped, which may be mistaken at times for the presence of fluid, lo eliminate this factor an assistant places the ulnar edge of his hand firmly on the abdominal wall in the median line, while the examiner taps the abdomen in the usual manner/' — (From Ashton's Gynecology.) 5. As to preference between the vaginal and abdominal routes, the following is taken from Garrigues' Gynecology: "If the vaginal route is available it should be preferred, because it entails much less shock, requires a simple after- treatment, does not leave any visible cicatrix, predisposes less to hernia, and allows the patient to resume work in shorter time. On the other hand, the vaginal route is more difficult on account of the limited space. Hemorrhage is more troublesome to check, adhesions are harder to sepa- rate, and the bladder and intestine more exposed to injury and less accessible for repair. The pelvic cavity cannot be seen so well and the abdominal not at all. If tissue is left to mortify it emits an offensive odor." 6. Symptoms of nbroids: Hemorrhage, leucorrhea, pain, pressure symptoms (disturbances and displacements of bladder, rectum, urethra, and uterus), backache, bearing- down sensation, dysmenorrhea. 7. Retroversion. Etiology: Relaxation of uterine liga- ments; increased weight of fundus; subinvolution; ovarian or other tumor pressing on front of uterus ; distended bladder; peritonitis or cystitis; prolonged dorsal decubitus and tight bandaging in the puerperium. Retroflexion. Etiology: Tight lacing and tight cloth- ing ; congenital conditions ; pressure by tumors ; metrititis and parametritis with adhesions ; atonic conditions of the uterus following labor, and the conditions that cause retro- version. 8. A complete gynecologica* examinaticn would include (1) anamnesis, including family history; personal history, with special reference to menstruation, labors, and mis- carriages, and present illness. (2) Examination of the abdomen (and breasts), including inspection, palpation, percussion, auscultation, and mensuration. (3) Inspection of the external genitals. (4) Vaginal examination, digital, bimanual, and with speculum. (5) Bimanual examination of uterus and appendages. (6) Sometimes the sound, or curette, may be required. (7) Chemical and microscopical examination of the urine. (8) Microscopical examination 17 MEDICAL RECORD. of discharges or uterine scrapings. (9) Rectal examina- tion. (10) Cystoscopic examination and perhaps ureteral catheterization. (11) In case of phantom tumor or pseudo- cyesis, anesthetization would be required. SURGERY. 1. The general rules for treatment of wounds: Stop the bleeding; remove foreign bodies; make as aseptic as pos- sible; coapt the edges; drain when necessary; dress, and secure rest to the part; bring about reaction; ease pain. 2. See Rose and Carless' "Surgery" (1908), page 112; or Da Costa's "Surgery" (1908), page 174. 3. See Rose and Carless' "Surgery" (1908), page 175; or Da Costa's "Surgery" (1908), page 154. 4. CHANCRE. First lesion of a constitu- tional disease, viz., syph- ilis. Due to syphilitic infection. Generally a venereal infec- tion. May occur anywhere on the body. Period of incubation never so short as ten days. Generally single. Not autoinoculable. Secretion slight. Slightly or not at all painful. As a rule only occurs once in any patient. Buboes are painless and sel- dom suppurate. CHANCROID. A local disease. Due to contact with secre- tion from chancroid. Always a venereal infec- tion. Nearly always on genitals. Period of incubation always less than ten days (gener- ally about three). Generally multiple. Autoinoculable. Secretion profuse and puru- lent. Generally painful. May reoccur in same patient. Buboes are painful and usually suppurate. 5. See Rose and Carless' "Surgery" (1908), page 481; or Da Costa's "Surgery" (1908), page 464. 6. See Rose and Carless' "Surgery" (1908), pages 620 621, and 622; or Da Costa's "Surgery" (1908), pages 588 and 590. 7. See Rose and Carless' "Surgery" (1908), pages 1175 and 1176; or Da Costa's "Surgery" (1908), pages 1110 and mi. . 8. See Rose and Carless' "Surgery" (1908), page 909; or Da Costa's "Surgery" (1908), page 821. 18 MEDICAL RECORD. EYE, EAR, NOSE, AND THROAT. 1. Acute catarrhal conjunctivitis. Symptoms: Hy- peremia, profuse lacrymation, epiphora, a profuse discharge, sensation of sand in the eye, and sometimes photophobia. Treatment : Astringent and antiseptic washes are of value. Ascertain the underlying cause, if possible, and remove it. Anointing the lids with pure or medicated vaseline every evening is necessary. Alum, tannic acid, silver nitrate, and zinc sulphate are valuable as astringents. In intractable cases a 50 per cent, solution of boroglycerid in glycerin should be applied once daily. — (Gould and Pyle's Cyclo- pedia.) 2. Gonorrheal ophthalmia. Symptoms: Swelling and redness of the eyes, the presence of a discharge which soon becomes purulent, the conjunctiva of the lids becomes thickened, the eyelids are edematous, pain is severe, and there is some fever. Dangers: Ulceration and sloughing of the cornea, perforation of the anterior chamber, and blindness. Management: Protect the sound eye. Wash the eye carefully every half hour with a saturated solution of boric acid; pus must not be allowed to accumulate. Two drops of a 2 per cent, solution of nitrate of silver must also be dropped onto the cornea every night and morning. The eyes must be covered with a light, cold, wet compress. The patient must be isolated, and all cloths and compresses used must be burnt. In adults the irrigation must be frequent, about every half hour or hour. 3. Management of corneal ulcer: The treatment con- sists in putting the eye at rest, instilling atropin, and the application of a bandage. Leeches to the temple will re- lieve the pain. Hot compresses have the same effect. The eye should be douched with sublimate solution, 1 :5ooo, and iodoform dusted upon the cornea. Stronger sublimate solution, boroglycerid 50 per cent., and formalin 10 per cent, are sometimes necessary. Cauterization is occa- sionally indicated. If perforation seems probable, it should be hastened by a puncture. — (Gould and Pyle's Cyclopedia.) 4. Cerumen may become impacted in the external au- ditory canal. It may cause deafness, tinnitus, giddiness, cough; it is diagnosed by being seen (with the aid of an ear speculum). Syringing with warm water containing sodium bicarbonate and glycerin ; if near the orifice, it may be removed with a spud. 5. In acute suppurative otitis media: Pain (lessened when drum perforates), fever (ioo° to 104 R), tinnitus, deafness (usually partial only), and purulent discharge (after perforation). Treatment: Dry heat allays the pain. Wanned water or warmed carbolic acid solution (1:40) 19 MEDICAL RECORD. may be used. Inflations, aspirations, etc., should be avoided. If the nares are filled with tough secretions, a spray of Dobell's solution may be used. If the pain con- tinues over six hours in a child or over twelve hours in an adult without spontaneous perforation of the tympanic membrane, paracentesis of that structure should be per- formed. The concha and meatus should be smeared with petrolatum to avoid chapping, and the secretions should be gently mopped off as they appear. Under this treatment the ear usually returns to normal in two to three weeks." — (Gould and Pyle's Pocket Cyclopedia of Medicine and Surgery. ) 6. To arrest epistaxis: (i) Try to cauterize the bleeding point; (2) plug the nasal cavity with gauze soaked in adrenalin; (3) inject into the nares a solution of peroxide of hydrogen; (4) plug the nares, anteriorly and poste- riorly; (5) an inflating plug may be used. 7. The most conclusive evidence of diphtheria is the finding of the Klebs-Loeffler bacillus. See French's "Prac- tice of Medicine" (1907), pages 192 and 196; or Osier's "Practice" (1909), pages 205 and 209. 8. Intubation is indicated in : Diphtheria, edema of glot- tis, and laryngeal obstruction. Laryngotomy in : Spasm of glottis, foreign body in the larynx, and dyspnea due to some sudden obstruction. See Rose and Carless' "Sur- gery" (1908), page 914; or Da Costa's "Surgery" (1908), page 770. HYGIENE AND MEDICAL JURISPRUDENCE. i. See French's "Practice of Medicine" (1907), pages 301, 326, and 307; or Osier's "Practice of Medicine" (1909), pages 115, 141, 120, and 144. 2. Immunity is the ability of a tissue or organism to resist infection. The absence or loss of this defensive power against infection is called susceptibility. 3. See French's "Practice of Medicine" (1907), page 107; or Osier's "Practice of Medicine" (1909), pages 97 and 99. 4. The school building should be as near as possible to the center of the area which it is to serve; the site should be airy and open, of sufficient size, and somewhat ele- vated; it should not be too near factories, busy streets, or railways; the soil should be as free as possible from organic matter. The building should be so planned that the corners < look towards the four points of the com- pass. In this way the sun will have access to each side and to every room during some part of the day. The building should have as few stories as possible. The walls should be of brick or stone, and should be pointed with cement; the inner surface of the wall should be 20 MEDICAL RECORD, cemented smooth. The foundations must be solid. The general arrangement will depend upon size of site, number of scholars, and number of required rooms. Fifteen square feet per child should be allowed. Details will have to be considered on : plans, accommodations to be pro- vided, shape and size of class rooms, distribution of rooms, teachers' rooms, corridors, entrances and stair- cases, playground, ventilation, heating, lighting, and plac- ing of windows, sanitation, lavatories, water supply, drink- ing water, sewage disposal, removal of refuse, sanitary appliances, and drainage. 5. Malpractice is a failure on the part of a medical prac- titioner to use such skill, care, and judgment in the treat- ment of a patient as the law requires ; and thereby the patient suffers damage. If due to negligence only, it is civil malpractice. But if done deliberately, or wrongfully, or if gross carelessness or neglect have been shown, or if some illegal operation (such as criminal abortion) be per- formed, it is criminal malpractice. 6. A delusion is a belief in something which has no real existence, but is purely imaginary; and o"ut of which the person cannot be reasoned. An illusion is a false or per- verted impression, received through one of the senses. 7. In tetanus, the onset is gradual, is apt to begin with trismus, swallowing is difficult or impossible, the condition is persistent, consciousness is dulled or lost, and there is history of a wound or injury. In strychnine poisoning the onset is more sudden, the muscles of the jaw and neck are generally the last to be affected, there are marked re- missions with muscular relaxation, consciousness is re- tained, and there is no history of a wound or injury. 8. The symptoms of acute poisoning by coal tar deriva- tives are given by Riley as follows : After a full toxic dose there soon follows a sense of chilliness and, especially in the case of antipyrin, nausea, and vomiting. The skin becomes cyanosed and covered with cold perspiration. The pulse becomes soft, slow, and weak, and the respirations slow and shallow, death usually resulting from respiratory paralysis. Occasionally paroxysms of sneezing have been observed. STATE BOARD EXAMINATION QUESTIONS. Board of Medical Examiners, Territory of Arizona. ANATOMY. 1. Give a description of the general lymphatic system. 2. Give the histology of compact bone. 3. Give the structure of the spinal cord. 21 MEDICAL RECORD. 4. Name the muscles of the back, grouping them in their different layers. 5. Give the origin, insertion, action, blood and nerve supply of the following muscles; occipitofrontalis, pector- alis major, deltoid, adductor longus, rectus abdominis, and sternomastoid. 6. Name the lobes and fissure of the brain. 7. Describe the peritoneum. 8. Name the anatomical structures derived from the epiblast, mesoblast, hypoblast. 9. Give the gross and minute anatomy of the kidney. 10. Describe the brachial plexus and give its distribu- tion. MATERIA MEDICA. i. Explain the distinction between the physiological action and the therapeutic use of drugs; between rational and empirical therapeutics. 2. What ratios do hypodermic and rectal dosage bear to that by the mouth? Give rule for children's dosage. 3. What are alkaloids ? Give the four official alkaloids of cinchona bark. 4. Give a safe and efficient dose for an adult of mor- phine sulphate ; strychnine sulphate, cocaine hydrobromide ; hyoscine hydrobromate ; tr. digitalis ; tr. aconite. 5. Give the active principles of digitalis ; give indica- tions and contraindications for the use of the drug in diseases of the heart. 6. Name five potassium salts commonly used in medi- cine. State dose. 7. Give source and action of ergot. 8. Name some of the chief alkaloids of opium and state the therapeutic differences in the use of opium and mor- phine. 9. What hypnotic should be avoided if patient has a weak heart? 10. What anesthetic do you use, and why do you pre- fer it? PHYSIOLOGY. 1. Upon what theory is physiology founded? What is the structural basis of all organisms? 2. Life is in its ultimate analysis the metabolism of plasm; define plasm and metabolism. Give chemical con- stituents of plasm. 3. Lymph : where elaborated ; how conveyed ; compo- sition and function. 4. Give source and function of adrenalin, thyroidin, and opsonin. 5. Describe the local peculiarities of the circulation of the blood in the brain, lungs, liver, and erectile organs. 22 MEDICAL RECORD. 6. Give mechanism of respiratory movements; ratio of respiration to pulse ; effects of atmospheric pressure on respiration; influence of respiratory movements on heart and circulation of the blood and lymph. 7. Give the source and action of the various secretions concerned in the process of digestion. 8. Where are the following centers: (a) Parturition, (b) auditory, (c) respiratory, (d) visual, (e) micturition? 9. Define: (a) Amnion, (b) corpus luteum, (c) leucin, (d) erythrocyte, (e) neuron, (/) hemolysin. 10. Distinguish between cerebral and spinal paralysis in (a) muscle-tonus, (b) nutrition of muscles, (c) electrical reactions of muscles. CHEMISTRY. 1. Define decomposition. Name three physical decom- posing agents. 2. Sulphur: (a) occurrence in nature, (&) physical and chemical properties, (c) what compound of sulphur is lib- erated in decomposing organic matter? 3. Give chemical formula for (a) hydrochloric acid, (b) sulphuric acid, (c) Epsom salts, (d) Rochelle salts, (e) Glauber salts. 4. What is an alkaloid? Name five important ones and give derivation of same. 5. What are ptomains ? Give usual symptoms present in ptomain poisoning. 6. Name the general properties of carbohydrates and mention the occurrences in nature. 7. Describe in detail (a) a chemical test for blood; (b) for pus in the urine, (c) What urinary test is considered most important from a diagnostic and prognostic stand- point in pulmonary tuberculosis? (d) How may the amount of total solids passed in the urine in 24 hours be approximated? (e) How many grains of total solids should a man weighing 160 pounds pass in 24 hours? (/) Give normal sp. gr. of human urine, (g) Give test for albumin in urine; (h) for sugar in urine. (1) What is the normal amount of urea passed by man in 24 hours, and give a method of estimating the amount excreted. 8. (a) Name a test by which arsenic may be detected with certainty, (b) Give antidote for arsenic poisoning. 9. Name some drugs which combined in a prescription would be chemically incompatible. Give chemical formulae. 10. Give chemistry of pancreatic ferment in digestion. PATHOLOGY. 1. In what diseases does hypertrophy of the heart most commonly result? Why? 2. What are the commonest underlying conditions in angina pectoris? 23 MEDICAL RECORD. 3. What are the microscopic characteristics of the ex- udate in croupous pneumonia? In catarrhal pneumonia? 4. What pathological conditions are productive of icterus? 5. Differentiate, pathologically, between a typhoid ulcer and a tuberculous ulcer of the intestine. 6. ^ Give the usual methods of metastatic extension of carcinoma and of sarcoma. 7. In what locations in the body is the typhoid bacillus found in typhoid fever? 8. Name the parasite of malaria and describe its develop- ment in the blood. 9. Describe briefly lesions in the cord in tabes dorsalis. 10. What is pathological leucocytosis ? PRACTICE. 1. Give differential diagnosis between measles, scarlet fever, and smallpox. 2. Give treatment of acute gastrointestinal catarrh in children. 3. Give predisposing cause and treatment of pulmonary hemorrhage. 4. Describe the etiology and pathology of typhoid fever. 5. Give diagnosis and treatment of pneumonia. 6. W r hat is the prognosis as to the cure of epilepsy? Treatment of epilepsy? 7. Give treatment of acute bronchitis. 8. What are the complications and sequelae of scarlet fever? 9. Give varieties of erysipelas, with treatment. 10. Give treatment of asthma. SURGERY. i< What is the point of election for ligation of the subclavian artery? Describe fully the technique. 2. Give differential diagnosis of osteosarcoma and tuber- culous knee-joint. 3. Differential diagnosis of renal and cystic calculi. Give treatment of each. 4. How does the Halstead differ from the Bassini opera- tion for inguinal hernia? 5. Symptoms, diagnosis, and treatment of prostatic hypertrophy. 6. Etiology, diagnosis, and treatment of fistula in ano. 7. Diagnosis and treatment of embolism of the mesen- teric vessels. 8. Diagnosis and treatment of ulcerative perforation of the intestine. 9. Differential diagnosis and treatment of hydrothorax and pyothorax. <* 24 MEDICAL RECORD. io. Describe minutely the operation for enucleation of the eye. OBSTETRICS. i. Describe the changes that take place in the mucous lining of the uterus preparing it for the reception of the fertilized ovum. If it becomes attached, what further changes take place? If it passes without becoming at- tached, what further changes? 2. Describe the conditions most likely to result in laceration of the cervix and perineum and what remedies would you use and what treatment would you employ to reduce the danger as much as possible? 3. Describe fully how you would conduct a face presen- tation. 4. Describe how you would conduct a breech presenta- tion to decrease the danger to both mother and child as much as possible. 5. Classify, give symptoms, and treatment of extra- uterine pregnancy. 6. Give classifications, symptoms, and treatment of pla- centa prsevia. 7. Give technique of obstetric asepsis and antisepsis dur- ing pregnancy, parturition, and the puerperium. 8. Mention four important causes of active uterine con- tractions of normal labor. 9. Give the cause and treatment of puerperal sepsis. 10. Give the three important diameters of the fetal head at term; the diameters of the normal female pelvis. GYNECOLOGY. 1. What are the most common causes of pelvic cellulitis? 2. State how chronic purulent salpingitis may cause sterility. 3. Give differential diagnosis between acute non- puerperal ovaritis and appendicitis. 4. Describe urethral caruncle and give treatment. 5. When is ventral fixation contraindicated? 6. What is vaginismus? Give its causes and treatment. 7. Give treatment in detail of retroversion of less than one year's standing. 8. Explain how fibroid tumors may cause ascites. 9. When would you perform trachelorrhaphy and when amputation of cervix in cervical lacerations? Give tech- nique of trachelorrhaphy. 10. What is the cause of chronic inflammation of Skene's glands? Give treatment. 25 MEDICAL RECORD, ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Board of Medical Examiners, Territory of Arizona. ANATOMY. i. See Cunningham's "Anatomy" (1909), page 904; or Gray's "Anatomy" (1908), page 772. 2. See Cunningham's "Anatomy" (1909), page 72; or Gray's "Anatomy" (1908), page 38. 3. See Cunningham's "Anatomy" (1909), page 456; or Gray's "Anatomy" (1*908), page 843. 4. Muscles of the Back. First layer: Trapezius, and Latissimus dorsi. Second layer: Levator anguli scapulae, Rhomboideus major and Rhomboideus minor. Third layer: Serratus posticus superior, Serratus pos- ticus inferior, Splenius capitis et colli. Fourth layer: Erector spinae, Iliocostalis, Longissimus dorsi, Spinalis dorsi, Cervicalis ascendens, Transversalis cervicis, Trachelomastoid, Complexus, Biventer cervicis, and Spinalis colli. Fifth layer: Semispinalis dorsi, Semispinalis colli, Mul- tifidus spinae, Rotatores spinae, Supraspinales, Interspinals, Extensor coccygis, Intertransversalis, Rectus capit'is posticus major, Rectus capitis posticus minor, Obliquus capitis superior, and Obliquus capitis inferior. 5. See Cunningham's "Anatomy" (1909). pages 395, 323, 328, 362, 426, and 405; or Gray's "Anatomy" (1908), pages 369, 466, 472, 522, 444, and 391. 6. Lobes of the brain: Frontal, parietal, occipital, tem- poral, central, limbic, and olfactory. Fissures of the brain: Longitudinal, transverse, Sylvian, of Rolando, calcarine, parietal, and parieto-occipital. 7. See Cunningham's "Anatomy" (1909), pages 1048 and 1097; or Gray's "Anatomy" (1908), page 1255. 8. From the epiblast are derived: The skin, and its appendages (hair, nails), and glands (including the mam- mary glands) ; the nervous system (brain, spinal cord, ganglia and nerves) ; the epithelial parts of the organs of special sense. From the mesoblast are derived: The skeleton; con- nective tissues ; muscles and bones ; heart, blood-vessels, lymphatics, and spleen; the urinary and generative organs. From the hypoblast are derived: The epithelial lining^ of the alimentary canal and its glands; the epithelial^ lining of the respiratory tract, Eustachian tube, thyroid and thymus. 9. See Cunningham's "Anatomy" (1909), page 1130; or Gray's "Anatomy" (1908), page 1419. 26 MEDICAL RECORD. io. See Cunningham's "Anatomy" (1909), page 622; or Gray's "Anatomy" (1908), page 994. MATERIA MEDICA. 1. The physiological action of a drug is the influence which the drug exerts upon the various bodily organs or tissues in a state of health. The therapeutic use signifies the use of drugs in accordance with "rational" or "em- pirical" usage as defined below. Rational therapeutics is the use of remedies based on a combined knowledge of their physiological action and of the pathological condition present in the patient. Empirical therapeutics is the use of remedies based on no other "reason" but that some one has found them use- ful or beneficial in conditions similar to the one under treatment. 2. If the dose by mouth, is one grain, the hypodermic dose would be about one-half grain, and the dose by rec- tum about one and a half grains. Rule for children's dosage: x Let x = the age of a patient ; then = the x + 12 fraction of the adult dose which the patient should receive. Thus, a patient of four years old should receive 4 4 1 = — = — of an adult dose. 4 + 12 16 4 3. Alkaloids are organic nitrogenized substances, alka- line in reaction, and capable of combining with acids to form salts in the same way that ammonia does. The four official alkaloids of cinchona bark, are : Quinine, quinidine, cinchonine, and cinchonidine. 4. Morphine sulphate, dose, gr. X A ; strychnine sulphate, dose, gr. 1/64; cocaine hydrobromide, not used, the dose of cocaine hydrochloride is gr. % ; hyoscine hydrobromate, dose, gr. 1/128; tr. digitalis, dose TT£xv; tr. aconite, dose TT£viij. 5. Digitalis. Active principles: Digitalin, digitalein, digitin, digitoxin, and digitonin. Digitalis is indicated in diseases of the heart, (1) when the heart action is rapid and feeble, with low arterial ten- sion ; (2) in mitral lesions when compensation has begun to fail; (3) in non-valvular cardiac affections; (4) in irritable heart, due to nerve exhaustion. Digitalis is contraindicated in diseases of the heart (1) in aortic lesions when uncom- bined with mitral lesions ; (2) when the heart action is strong, and arterial tension high. 6. Five potassium salts: Potassium bromide, dose, gr. xv : potassium iodide, dose, gr. vijss; potassium acet- ate, dose, gr. xxx; potassium citrate, dose, gr. xv; potas- sium chlorate, dose, gr. iv. 27 MEDICAL RECORD 7. Ergot. Source: The sclerotium of the claviceps pur- purea. Physiological action: Ergot stimulates and causes con- traction of involuntary muscle fibers, hence it is a vaso- constrictor, hemostatic, and oxytocic. It is also a cardiac sedative, it raises the blood pressure, it increases peristal- sis, and is an emmenagogue. 8. The chief alkaloids of opium, are: Morphine, codeine, thebaine, narceine, narcotine, papaverine, and pseudomor- phine. Therapeutic differences in the use of opium wnd mor- phine: Opium is more slowly absorbed, acts more slowly, the effect lasts longer, and its immediate local effect on the intestines is more marked. Morphine is less irritating, less constipating, less, diaphoretic, less stimulating to the heart and nervous system, and affects the secretions less than opium. Morphine is more liable to cause skin eruption and itching, it is more certain and rapid as an anodyne and hypnotic, and is also more quickly elim- inated. 9. If a patient has a weak heart, chloral should not be used as a hypnotic. 10. Ether; because it is safer (as shown by statistics). And see Rose and Carless' "Surgery" (1908), page 1323; or Da Costa's "Surgery" (1908), page 1026. PHYSIOLOGY. 1. Physiology is not founded upon any theory; it is rather based upon a knowledge of anatomy, histology, chemistry and physics. Perhaps the examiner wants "Virchow's cellular theory ." Cells are the structural basis of all organisms. 2. Plasm (or protoplasm) is the physiological basis of life, being the substance of which the cells are made. Metabolism is the name given to the entire series of changes which occur in ja cell or organism during the processes of nutrition. It is of two kinds: (1) Assimila- tive, or constructive, called anabolism; and (2) destruc- tive, called katabolism. The chemical constituents of protoplasm, are: Water, and solids; the chief of the latter are proteids (which con- tain carbon, hydrogen, oxygen, nitrogen, sulphur, phos- phorus) ; lecithin; cholesterin; and chlorides and phos- phates of calcium, sodium, and potassium. 3. Lymph. Elaboration: There are two theories as to the formation of lymph: (1) That it is formed from the blood plasma by the processes of filtration, diffusion, and osmosis. (2) That, in addition to these, the endothelial cells of the capillaries exercise some influence. It is conveyed by the lymphatic circulation, which is, 28 MEDICAL RECORD. strictly speaking, not a circulation at all ; since the lymph flows only in one direction, namely, toward the heart. The lvmph capillaries take up any excess of the blood plasma which is not required for the nutrition of the tis- sues. These capillaries consist of a single layer of epithe- lium, and empty themselves into vessels very like the veins. The lymph vessels are well provided with valves, which are so closely approximated as to give the vessels a beaded appearance. All the lymphatic vessels, except those of the right upper half of ti* : body empty into the thoracic duct, which terminates in the left subclavian vein, where the left internal jugular vein also enters. Those from the right upper half of the body discharge into the right lymphatic duct, which, in turn, empties into the right subclavian vein at its junction with the right internal jugu- lar vein. Composition: Lymph plasma (fibrinogen, serum globu- lin, and serum albumin) and lymphocytes. Function: Nutrition of tissues. 4. Adrenalin is obtained from the medulla of the suprarenal gland. It is supposed to maintain the tonicity of the muscles, also to maintain the blood pressure, and to stimulate the muscle fibers of the heart and arteries. Thyroidin is found in the thyroid gland. It is supposed to have some favorable influence on general metabolism, and to antagonize certain toxic substances. Opsonin has its origin in the blood serum. It is said to increase the phagocytic action of the leucocytes. 5. In the brain: This organ requires a large supply of blood, which is supplied by the two internal carotids and the two vertebrals. To lessen the pressure the arteries are very tortuous and anastomose freely in the circle of Willis. These two factors ensure a uniform supply of blood to the brain. The venous trunks or sinuses are so arranged as to allow little or no change in size, and are neither com- pressible nor distensible. In the lungs: "The lungs receive blood from two sources, (a) the pulmonary artery, (b) the bronchial ar- teries. The former conveys venous blood to the lungs for its arterialization, and this blood takes no share in the nutrition of the pulmonary tissues through which it passes. (b) The branches of the bronchial arteries ramify for nutrition's sake in the walls of the bronchi, of the larger pulmonarv vessels, in the interlobular connective tissue, etc. ; the blood of the bronchial vessels being returned chiefly through the bronchial and partly through the pul- monary veins." In the liver: The portal vein, the hepatic artery, and the hepatic duct run together through the substance of the liver. "To take the distribution of the portal vein first: 29 MEDICAL RECORD, In its course through the liver this vessel gives off small branches which divide and subdivide between the lobules surrounding them and limiting them, and from this cir- cumstance called inter-lobular veins. From these small vessels a dense capillary network is prolonged into the substance of the lobule, and this network, gradually gather- ing itself up, so to speak, into larger vessels, converges finally to a single small vein, occupying the center of the lobule, and hence called in^ra-lobular. The small intra- lobular veins discharge their contents into veins called sub- lobular, while these again, by their union, form the main branches of the hepatic veins, which leave the posterior border of the liver to end by two or three principal trunks in the inferior vena cava, just before its passage through the diaphragm. The hepatic artery, the chief function of which is to distribute blood for nutrition to Glisson's capsule, the walls of the ducts and blood-vessels, and other parts of the liver, is distributed in a very similar manner to the portal vein, its blood being returned by smaller branches either into the ramifications of the portal vein, or into the capillary plexus of the lobules which con- nect the inter- and intra-lobular veins. The hepatic duct divides and subdivides in a manner very like that of the portal vein and hepatic artery, the larger branches being lined by cylindrical, and the smaller by small polygonal epithelium. The bile capillaries commence between the hepatic cells, and are bounded by a delicate membranous wall of their own. They appear to be always bounded by hepatic cells on all sides, and are thus separated from the nearest blood capillary by at least the breadth of one cell." — (From Kirkes' Physiology.) The erectile tissues are susceptible of turgescence and increase in size; they contain a collection of arteries and veins, the latter being tortuous and varicose and contained in spaces formed by trabecular of fibrous tissue. 6. Mechanism of respiratory movements: See Cunning- ham's "Anatomy" (1909), pages 415 and 419; or Gray's "Anatomy" (1908), pages 289 and 433. Ratio of respira- tion to pulse is about 1 '.4. Effects of atmospheric pressure on respiration: Decrease of pressure causes nose bleed, dyspnea, convulsions ; increase of pressure may cause dyspnea or tetanic convulsions. Influence t of respiratory movements on heart and circulation: Inspiration aids the circulation and so increases the arterial tension; expira- tion does not materially aid or hinder circulation; violent extirpation may obstruct circulation. 7. The various secretions concerned in the process of digestion, are the saliva, gastric juice, pancreatic juice, bile, and succus entericus. The source of the saliva is the salivary glands; of the 30 MEDICAL RECORD gastric juice, the glands of the stomach; of the pan- creatic juice, the pancreas; of the bile, the liver; and of the succus entericus, the glands of the small intestine. The functions of the saliva are: (i) To moisten the mouth, (2) to assist in the solution of the soluble portions of the food, and thus (3) to administer to the sense of taste, (4) to lubricate the bolus of food, and thus (5) to facilitate the acts of mastication and deglutition, and (6) to change starches into dextrin and sugar. The functions of the gastric juice are: (1) To change proteids into proteoses and peptones, and (2) to curdle the casein of milk. The functions of the pancreatic juice are: (1) To change proteids into proteoses and peptones, and afterwards de- compose them into leucin and tyrosin; (2) to convert starch into maltose; (3) to emulsify and saponify fats; and (4) to cause milk to curdle. The functions of the bile are: (1) To assist in the emulsification and saponification of fats; (2) to aid in the absorption of fats; (3) to stimulate the cells of the intes- tine to increased secretory activity, and so promote peris- talsis, and at the same time tend to keep the feces moist; (4) to eliminate waste products of metabolism, such as lecithin and cholesterin; (5) it has a slight action in con- verting starch into sugar; (6) it neutralizes the acid chyme from the stomach and thus inhibits peptic digestion; (7) it has a very feeble antiseptic action. The functions of the succus entericus are : The secre- tion of enterokinase, secretin, and crepsin, which assist the pancreatic juice in digestion. 8. The center for (a) parturition is in the lumbar en- largement of the spinal cord; (b) auditory, is in the first and second convolutions of the temporal lobes of the brain ; (c) respiratory, is in the floor of the fourth ven- tricle ; (d) visual, is in the occipital lobes of the brain; (e) micturition, is in the lumbar enlargement of the spinal cord. 9. (a) Amnion, is the innermost of the fetal mem- branes, it secretes and contains the liquor amnii. (b) Corpus luteum is the scar or yellow body left on the ovary at the site where a Graafian follicle has dis- charged its ovum. (c) Leucin is amidocaproic acid; it is found in the pan- creas, spleen, liver, kidneys, thymus, lymphatic and sali- vary glands ; it is due to the decomposition of proteins by acids or alkaloids, and during putrefaction. (d) Erythrocyte is a red blood-corpuscle. (e) Neuron is a nerve cell with all its processes. (/) Hemolysin is "a substance produced in the body of one species of animal by the introduction of red blood 31 MEDICAL RECORD. corpuscles derived from the body of another species; it is capable of dissolving the red blood corpuscles of the ani- mal species from which the blood was obtained." — Gould. 10. Cerebral Paralysis. Spinal Paralysis. (a) Muscle tonus. Spastic ; may be contractures. Flaccid. (b) Nutrition of Normal, or slight Marked atrophy. muscle atrophy. (c) Electrical re- Normal. Little or no re- action sponse to fara- dic current ; par- tial or complete reaction of de- generation t galvanic current. CHEMISTRY. 1. Decomposition is the splitting up of a compound into simpler compounds or into its constituent element's. Three physical decomposing agents : Heat, light, and electricity. 2. Sulphur, (a) Occurrence in nature: It is found free, also in combination in the sulphides and sulphates, and in proteids, especially the keratins. (b) Physical and chemical properties: Yellow crystal- line solid, slight odor and taste which are characteristic, insoluble in water, soluble in carbon disulphide, it is di- morphous; on being heated, it first fuses to a thin yellow liquid, on further heating it becomes thick and brown, at a still higher temperature it again becomes thin and lighter in color, and at a higher temperature again it boils, at the same time giving off a brownish-yellow vapor. Suphur has a valence of two or six, atomic weight of 32, molecular weight of 64; it readily combines with other elements ; heated in air or oxygen, sulphur dioxide is pro- duced; if burnt in hydrogen, hydrogen sulphide is pro- duced. The compounds of sulphur are similar in consti- tution and (to some extent) in chemical properties to the compounds of oxygen. (c) In decomposing organic matter, sulphuretted hydro- gen H 2 S is liberated. 3. («) Hydrochloric acid, HC1; (b) sulphuric acid, HsjSCX; (c) Epsom salts, MgS0 4 ; (d) Rochelle salts, NaKCJLOa; (e) Glauber salts, Na 2 S0 4 . 4. An alkaloid is a basic nitrogenous substance of alka- line reaction and capable of acting with an acid to form salts in the same way that ammonia does. 32 MEDICAL RECORD Five important alkaloids: (i) Strychnine, from strychnos nux vomica; (2) Atropine, from atropa bella- donna; (3) Coniine, from Conium maculatum; (4) Nico- tine, from tobacco; (5) Cocaine, from coca erythroxylon. 5. Ptomains are basic, nitrogenous compounds, pro- duced from protein material by the bacteria which cause putrefaction. Ptomain poisoning. Symptoms: Chilliness, headache, vertigo, muscular twitchings, hallucinations, imperfect vision, weak and rapid pulse, nausea, vomiting, diarrhea, cyanosis, early dyspnea, often subnormal temperature, and occasionally cutaneous eruptions. The prognosis is guard- edly favorable. 6. Carbohydrates. "The carbohydrates are bodies com- posed of C, H, and O, as aldehydes and ketols. They are classified as monosaccharides, dextrose, galactose, etc. These are the simplest molecules of the hexoses. They are sweet, odorless, soluble in water, and oxidize readily, hence their reducing power. They form crystalline osa- zones. They rotate polarized hVht. Their formula is CeH^Oe. Disaccharides, maltose, saccharose, lactose, etc. They are formed by the union of two simpler molecules and the elimination of a molecule of water. They have the formula G2H22O11. And polysaccharides, glycogen, starch, dextrin, gum, etc. They are much less soluble, can be hydrolyzed into the simpler forms, and have the formula (CeHioC^n. "Monosaccharides are especially soluble and polysaccha- rides are especially insoluble; monosaccharides and disac- charides do not give colored solutions with iodine, while polysaccharides do; monosaccharides and (except sac- charose) disaccharides reduce Fehling's solution, while polysaccharides do not." — (Kirkes' Physiology.) Occurrences: Starch, cellulose, plants, seeds, roots, fruits, sugar. 7. (a) Chemical test for blood in the urine: To the urine add a solution of potassium hydroxide to distinct alkaline reaction; heat nearly to boiling (do not boil). A red precipitate is produced. (b) For pus in the urine: Acidify the urine with acetic acid, then filter it, and treat the filter with a few drops of freshly prepared tincture of guaiacum ; a deep blue color denotes the presence of pus. (c) Ehrlich's diazo reaction. (d) and (e) The average amount of solids in the urine is about 850 to 950 grains in twenty-four hours. It can be estimated as follows : Take the specific gravity of the twenty-four hours' output ; multiply the two last figures of this specific gravity by the number of ounces of urine 33 MEDICAL RECORD. passed in the twenty-four hours ; multiply this product by i.i; this represents the total urinary solids in grains. (/) The normal specific gravity of the urine is about 1015 to 1025. (g) Test for albumin: "The urine must be perfectly clear. If not so, it is to be filtered, and, if this does not render it transparent, it is to be treated with a few drops of magnesia mixture, and again filtered. "The reaction is then observed. If it be acid, the urine is simply heated to near the boiling point. If the urine be neutral or alkaline, it is rendered faintly acid by the addition of dilute acetic acid, and heated. If albumin be present, a coagulum is formed, varying in quantity from a faint cloudiness to entire solidification, according to the quantity of albumin present. The coagulum is not redis- solved upon the addition of nitric acid." (h) Test for sugar: First remove any albumin that may be present, then "render the liquid strongly alkaline by addition of sodium carbonate. Divide about 6 c.c of the alkaline liquid in two test-tubes. To one test-tube add a. very minute quantity of powdered subnitrate of bismuth, to the other as much powdered litharge. Boil the contents of both tubes. The presence of glucose is indicated by a dark or black color of the bismuth powder, the litharge retaining its natural color." (i) The normal amount of urea passed by a man in twenty-four hours is about five hundred and twenty grains. A comparatively easy test for Urea is that of Fowler, based upon the loss of the specific gravity of the urine after the decomposition of the urea by hypochlorite. "To apply this method the specific gravity of the urine is care- fully determined, as well as that of the liquor sodse chlorinatse (Squibb's). One volume of the urine is then mixed with exactly seven volumes of the liquor sodae chlorinatse, and, after the first violence of the reaction has subsided, the mixture is shaken from time to time during an hour, when the decomposition is complete ; the specific gravity of the mixture is then determined. As the reaction begins instantaneously when the urine and reagent are mixed, the specific gravity of the mixture must be calcu- lated by adding together once the specific gravity of the urine and seven times the specific gravity of the liquor sodse chlorinatse, and dividing the sum by eight. From the quotient so obtained the specific gravity of the mix- ture after decomposition is subtracted; every degree of loss in specific gravity indicates 0.7791 gram of urea in 100 c.c. of urine. The specific gravity determinations must all be made at the same temperature ; and that of the mixture only when the evolution of gas has ceased entirely." — (Witthaus' Manual of Chemistry.) 34 MEDICAL RECORD. 8. {a) Test for arsenic: Reinsch's test is as follows : To the suspected fluid add a little pure HC1 ; suspend in the fluid a small strip of bright copper foil, and boil. If a deposit forms on the copper, remove the copper, wash it with pure water, dry on filter paper, but be careful not to rub off the deposit. Coil up the copper, and put it into a clean dry glass tube, open at both ends, and apply heat at the part where the copper is. If arsenic is present there will appear in the cold part of the tube a mirror, which will be found on microscopical examination to consist of octahedral crystals of arsenic trioxide. (b) The chemical antidote for arsenic poisoning is freshly prepared ferric hydroxide. The ferric hydroxide changes the arsenic into ferrous arsenate, which is non- poisonous. 9. Lead acetate, Pb (C2H.3O2), and Potassium iodide, KI, are chemically incompatible in a prescription. 10. The pancreatic juice contains three ferments: (1) Trypsin, which changes proteids into proteoses and pep- tones, and afterwards decomposes them into leucin and tyrosin ; it only acts in an alkaline or faintly acid me- dium. (2) Amylopsin, which converts starches into mal- tose. (3) Sieapsin, which emulsifies and saponifies fats. PATHOLOGY. i. Hypertrophy of the heart most commonly results from the following diseases : Arteriosclerosis, chronic in- terstitial nephritis, exophthalmic goiter, valvular disease (particularly aortic), pulmonary emphysema, adherent peri- cardium. 2. The commonest underlying conditions in angina pec- toris, are : Arteriosclerosis (either general, or of the aorta) ; obstruction of the coronary arteries, from ather- oma, embolism or thrombosis ; degeneration of the myo- cardium. 3. See French's "Practice of Medicine" (1907), pages 155 and 671; or Osier's "Practice of Medicine" (1909).. pages 170 and 620. 4. Pathological conditions productive of icterus, are: Catarrh of the duodenum and common bile duct, pancre- atic disease, gallstones, cirrhosis of the liver, obstruction of the bile ducts, septicemia, acute yellow atrophy of the liver, tumors of liver, pancreas, stomach, or kidney. 5. In the typhoid ulcer: (1) The main axis of the ulcer lies parallel with that of the intestine ; (2) it lies opposite to the mesenteric attachment; (3) it has smooth floor and undermined edges ; (4) it commonly leads to perforation. In tuberculous ulcer: (1) The long axis of the ulcer lies at right angles to that of the intestine ; (2) it is not 35 MEDICAL RECORD. necessarily situated opposite the mesenteric attachment; (3) its floor is not smooth nor are its edges undermined, but rather funnel-shaped and irregular; (4) it is not apt to perforate, but it does not tend to heal, rather to spread. 6. The usual method of metastatic extension of carci- noma, is by the lymphatics, occasionally by the blood-ves- sels ; of sarcoma, by the blood-vessels. 7. In typhoid fever, the typhoid bacillus may be found in : The intestinal lesions, intestinal contents, spleen, liver, kidneys, urine, blood of the macular spots in the skin, lungs, parotid glands. 8. See French's " Practice of Medicine" (1907), page 233; or Osier's "Practice of Medicine" (1909), page 12. 9. In locomotor ataxia, the posterior columns of the spinal cord are gray and shrunken and show considerable overgrowth of connective tissue in the columns of Goll, B.urdach, and Lissauer; this process extends upward from the lumbrosacral region; the posterior nerve roots degen- erate and become atrophic. The meninges over the af- fected parts become opaque and adherent. 10. Pathological leucocytosis is an increase in the num- ber of the white blood corpuscles when associated with diseased conditions, or when not accompanying mere physi- ological processes, such as pregnancy, lactation, exercise, digestion, etc. PRACTICE. 1. Scarlet fever: Period of incubation, from a few hours to seven days. Stage of invasion, twenty-four hours. Character of eruption, a scarlet punctate rash, beginning on neck and chest, then covering face and body; desqua- mation is scaly or in flakes. The eruption is brighter, is on a red background, punctiform, and is more uniform; the temperature is higher, the pulse quicker; the tongue is of the "strawberry" type, the lymphatics in the neck may be swollen, and there is sore throat; Koplik's spots are absent. Smallpox: The eruption usually appears first on the forehead and wrists, and on the third or fourth day; it is first mascular, then papular, then vesicular, and finally pustular; it does not appear in successive crops; the spots are multilocular, and do not collapse on being punctured; the papule is hard and shotty, and does not disappear on stretching the skin. Period of incubation is from eight to fourteen days. Measles: Period of incubation, ten to twelve days. Stage of invasion, four days. Character of eruption, small, dark red papules with crescentic borders, beginning on face and rapidly spreading oyer the entire body; desquamation is branny. The eruption is darker, less uniform; more shotty; the temperature is lower, pulse slower, the tongue is not of the "strawberry" type ; coryza, 36 MEDICAL RECORD. coughing, and sneezing may be present; Koplik's spots are present. 2. See French's "Practice of Medicine" (1907), page 781 ; or Osier's "Practice of Medicine" (1909), page 509. 3. See French's "Practice of Medicine" (1907), page 666; or Osier's "Practice of Medicine" (1909), page 617. 4. See French's "Practice of Medicine" (1907), pages 65 and 70; or Osier's "Practice of Medicine" (1909), pages 57 and 65. 5. See French's "Practiceof Medicine" (1907), pages 171 and 174; or Osier's "Practice of Medicine" (1909), pages 172 and 189. 6. See s French's "Practice of Medicine" (1907), page 1 132; or Osier's "Practice of Medicine" (1909), page 1064. 7. See French's "Practice of Medicine" (1907), page 650; or Osier's "Practice of Medicine" (1909), page 603. 8. See French's "Practice of Medicine" (1907), page 320; or Osier's "Practice of Medicine" (1909), page 134. 9. See French's "Practice of Medicine" (1907), pages 218 and 221; or Osier's "Practice of Medicine" (1909), page 213. 10. See French's "Practice of Medicine" (1907), page 661; or Osier's "Practice of Medicine" (1909), page 612. SURGERY. 1. See Rose and Carless' "Surgery" (1908), page 333; or Da Costa's "Surgery" (1908), page 410. 2. See Da Costa's "Surgery" (1908), page 558; and Rose and Carless' "Surgery" (1908), page 604. 3. See Rose and Carless' "Surgery" (1908), pages 1175 and 1212; or Da Costa's "Surgery" (1908), pages 11 10 and 1 132. 4. The Halstead differs from the Bassini operation for inguinal hernia, in that in the Halstead operation: (1) A new and closely fitting internal ring is made; (2) the internal oblique and transversalis muscles are incised as well as the external oblique; (3) the spermatic cord is left between the skin and the aponeurosis of the external oblique ; and (4) most of the veins of the spermatic cord are excised. 5. Symptoms of hypertrophy of the prostate gland: Slowness in starting urination; difficult micturition; fre- quency of micturition, particularly at night; the presence of residual urine; dull, aching pain in the perineum and above the pubes ; enlargement of the lateral lobes of the prostate; there may be cystitis and retention of urine. Treatment consists in : Catheterization, under proper pre- cautions ; prostatectomy may be required ; formerly less radical measures were occasionally employed, such as cas- tration, vasectomy, and Bottini's operation. 37 MEDICAL RECORD. 6. See Rose and Carless' "Surgery" (1908), page 1134; or Da Costa's "Surgery" (1908), page 1010. 7. Embolism of the mesenteric vessels is diagnosed by the sudden onset of intense pain, which is sometimes per- sistent and sometimes has paroxysms of extra intensity, rapid pulse, subnormal temperature, abdominal rigidity, exhaustion, nausea, vomiting, and in about half the cases bloody diarrhea ; meteorism may be present, and a mass may be palpated over the affected region. Treatment: Exploratory laparotomy, and if the affected area is small, resection of the part of the intestine involved is indicated. If a large portion of the intestine is gan- grenous, little or nothing can be done. 8. See Rose and Carless' "Surgery" (1908), page 1009; or Da Costa's "Surgery" (1908), page 845. 9. See French's "Practice of Medicine" (1907), pages 702 and 696; and Da Costa's "Surgery" (1908), page 774. - 10. Enucleation of the eyeball is performed as follows : "A general anesthetic is generally given. After introduc- tion of the speculum, the conjunctiva is divided all around the cornea, as close to its border as possible, and dissected back as far as the insertions of the recti muscles. A squint hook is passed beneath the tendon of the internal rectus, and the latter is divided with the strabismus scissors close to its insertion; then the other straight muscles are cut in the same way, together with the subconjunctival con- nective tissue for some distance beyond the equator. The points of the scissors must always be directed toward the eyeball and the latter stripped as clean as possible to avoid any unnecessary removal of orbital tissue. Instead of commencing with a circumcorneal division of the conjunc- tiva, we may begin with a tenotomy of tfie internal rectus and then divide the conjuctiva as we pass from tendon to tendon. The hook is passed around the globe to make sure that the attachments of the muscles have been com- pletely divided. The eyeball is then dislocated forward by pressing the speculum backward, and thus the optic nerve is put on the stretch. A pair of enucleation scissors, closed, are passed between sclera and conjunctiva, feeling for the optic nerve ; they are withdrawn, slightly opened, and the nerve is divided close to the sclera. The eyeball is held between the thumb and index finger of the left hand, and the oblique muscles, and other unsevered attach- ments are divided. The orbit is plugged for a few minutes to control hemorrhage, and the conjunctiva is usually closed with a single suture, which is passed through its edge at intervals and tied like the string of a pouch. The eye is bandaged and the patient kept in bed for a day." — (May, Diseases of the Eye.) 38 MEDICAL RECORD. OBSTETRICS. i. See Williams' "Obstetrics" (1909), pages 81 and 119; or Hirst's ''Obstetrics" (1909), pages 58 and 143. 2. See Williams' "Obstetrics" (1909), pages 830, 316, and 419; or Hirst's "Obstetrics" (1909), pages 898, 333, 607, and 86j. 3. If the chin is presenting anteriorly, expectant treat- ment may suffice ; but care must be taken to observe that the chin does not rotate backwards. Spontaneous version may occur, and the presentation become a vertex one. Failing this, or as a means of favoring this, postural treatment, such as Walcher's position, has been recom- mended. If, in spite of this, engagement has not occurred, cephalic version is indicated, care being taken not to rup- ture the membranes. If this is not successful, podalic version should be tried. If, after all these manipulations, the child is still alive and the head is engaged, symphyse- otomy is indicated; if the child is dead, craniotomy should be performed. 4. See Williams' "Obstetrics" (1909), page 289; or Hirst's "Obstetrics" (1909), page 425. 5. The varieties of ectopic pregnancy are: (1) Tubal, (2) interstitial, (3) ovarian, and (4) abdominal. In differentiating this condition from a normal preg- nancy, the following signs and symptoms are of most reli- ance : "When extrauterine pregnancy exists, there are: (1) The general and reflex symptoms of pregnancy; thev have often come on after an uncertain period of sterility. Nau- sea and vomiting appear aggravated. (2) Then comes a disordered menstruation, especially metrorrhagia, accom- panied with gushes of blood, and with pelvic pain coinci- dent with the above symptoms of pregnancy. Pains are often very severe, with marked tenderness within the pelvis. Such symptoms are highly suggestive. (3) There is the presence of a pelvic tumor characterized as a tense cyst, sensitive to the touch, actively pulsating. This tumor has a steady and progressive growth. In the first two months it has the size of a pigeon's egg; in the third month it has the size of a hen's egg ; in the fourth month it has the size of two fists. (4) The os uteri is patulous : the uterus is displaced, but is slightly enlarged and empty. (5) Symptoms No. 2 may be absent until the end of the third month, when suddenly they become severe, with spasmodic pains, followed by the general symptoms of col- lapse. (6) Expulsion of the decidua, in part or whole. Xos. 1 and 2 are presumptive signs; Xos. 3 and 4 are probable signs; Xos. 5 and 6 are positive signs." — (Amer- ican Text-Book of Obstetrics.) Treatment consists in removal of the product of con- 39 MEDICAL RECORD. ception, by a laparotomy, as soon as the diagnosis is made. 6. See Williams' "Obstetrics" (1909), page 809; or Hirst's "Obstetrics" (1909), page 574. 7. See Hirst's "Obstetrics" (1909), pages 773, etc. 8. (1) Increased muscular irritability of the walls of the uterus; (2) exaggerated reflex excitability of the spinal cord; (3) distention of the uterus; (4) movements of the child. 9. See Williams' "Obstetrics" (1909), page 852; or Hirst's "Obstetrics" (1909), page 712. 10. Fetal head: Occipito-mental, about 5^2 inches; oc- cipitofrontal, about 4^ inches ; sub-occipito-bregmatic, about 3J/2 inches. The pelvic diameters: Antero-posterior. Oblique. Transverse. Inlet 4 inches 4 T A inches 5 inches Outlet 5 inches 4^2 inches 4 inches GYNECOLOGY. 1. The most common causes of pelvic cellulitis, are : Traumatism during labor or the puerperium, abortions, sepsis, gonorrhea, an ill-fitting pessary, spread of inflam- mation from any part of the genital tract. 2. Chronic purulent salpingitis may cause sterility, by : Destroying the cilia in the tube, and so hindering the transmission of the ovum ; causing adhesions, thickening, stenosis, kinking, or atresia of the tube, and thus hinder- ing the transmission of the ovum ; pathological secretions may also destroy the ovum. 3. In appendicitis the pain is of sudden onset -and is localized in the right iliac fossa; there is abdominal rigi- dity, chiefly of the right rectus muscle, and tenderness at McBurney's point; there are usually fever, nausea, vomit- ing, and constipation. In inflammation of the right ovary the pain is not local- ized, but may be bilateral, and spreads to the vagina and rectum; there is no tenderness at McBurney's point; it is usually worse just before the menstrual period, which sometimes affords relief ; on vaginal examination the ovary is found to be tender. 4. Urethral caruncle is a small red fleshy growth gener- ally situated on the posterior part of the meatus of the urethra. There are local pain and tenderness, which may be excessive ; a burning sensation is experienced on urina- tion ; it may bleed. The proper treatment is to excise it or destroy it with the thermocautery. 5. Ventral -fixation is contraindicated when there is any possibility of a future pregnancy. 6. Vaginismus is a condition of painful and spasmodic contraction of the vaginal orifice, which renders coitus 40 MEDICAL RECORD. either painful or altogether impossible. Its causes are irritable hymen, ulcer, or fissure anywhere in the immedi- ate vicinity, urethral caruncle, carunculae myrtiformes, a long perineum with vaginal orifice placed too anteriorly. The treatment consists in removing the cause when pos- sible, tonics and general constitutional treatment, dilatation of the vaginal orifice ; local application of a 5 per cent, solution of cocaine will relieve the hyperesthesia and allow coitus. The condition is sometimes incurable. 7. The palliative treatment of retroversion of the uterus consists in: (1) Removing the cause, if possible; (2) re- placing the uterus; (3) keeping the uterus in position by means of pessaries, tampons, and knee-chest position; (4) tampons, ichthyol, pelvic massage, and vaginal douches; (5) the enforcing of proper hygiene, particular attention being paid to the bowels, clothing, and exercise. Curative treatment is operative, and the choice lies be- tween ventral suspension of the uterus and shortening of the round ligament. 8. Fibroid tumors cause ascites by pressure on the large vessels which thus induces an effusion of liquid through the walls of these vessels. 9. Trachelorrhaphy should be done : When the lesion is slight, and there is not much loss of tissue or erosion; or in uncomplicated cases. Amputation should be done: When the lesion is greater, or stellate, or where there is much loss of tissue, or when complications are present. 10. Generally gonorrhea, or maybe tuberculosis. Treatment: The tubules should be slit open and cauter- ized with pure carbolic acid, or excised. STATE BOARD EXAMINATION QUESTIONS. Arkansas State Board of Medical Examiners. anatomy. 1. At what time in the development of the fetus is the hair formed? 2. Give the general classification of bones. 3. Name the bones of the upper extremity. 4. Describe the diaphragm, giving origin, insertion, nerve supply, and action. 5. Name the superficial group of the muscles of the abdomen. 6. Name the openings of the heart. 7. Name the branches of the anterior tibial artery. 8. Describe the pia-mater. 9. Describe the uterus. 10. Describe the gall-bladder. 4i MEDICAL RECORD. PHYSIOLOGY. 1. Name and describe the glands of the intestines and tell in which portion of the intestine each kind is situated. 2. Describe the glycogenic function of the liver and tell the destination of glycogen. 3. Give origin, distribution, and function of the fifth pair of cranial nerves. 4. (a) How is the nervous system arranged anatomi- cally? (b) Give a short sketch of each system. 5. How many .pairs of spinal nerves are there? De- scribe them. CHEMISTRY. 1. What is albumin? 2. In what form in nature do we find albumin in its purest form? 3. In what case of poisoning do we use albumin as an antidote? 4. Name a metallic poison for which albumin is espe- cially recommended. 5. What is meant by toxicology? 6. What causes the decay of animal or vegetable matter when deprived of life? 7. What is meant by ptomain poison? 8. What is the origin of ptomain poison, or, in other words, how and from what are ptomains derived? 9. When the atmosphere we live in becomes charged with an excess of carbonic acid, how is it purified and made fit for the support of animal life? MATERIA MEDICA AND THERAPEUTICS. i. What is an alkaloid, a tincture, a fluid extract? 2. Name four different classes of medicine, with an ex- ample of each class. Give dose of example. 3. What drugs would you use hypodermatically to meet the following requirements? (3.) To stimulate the heart's action; (b) to produce emesis ; (c) to control hemorrhage. 4. What is the strength of normal salt solution? Give indications for its use and mode of administration. 5. Give principal alkaloid of belladonna and indications Cor its use ; also dose. 6. Name the three (3) most used preparations of opium, and how much of each contains one grain of opium. 7. Give hypodermatic dose of the following: Sulphate of strychnine, sulphate of atropine, sulphate of morphine, apomorphin hydrochlorate, nitroglycerin, and pilocarpine hydrochlorate. 8. Write a complete prescription for a diuretic contain- ing not less than three ingredients. 42 MEDICAL RECORD 9. How are the cathartic effects produced by salines? 10. How is nitrite of amyl used, and for what purpose? PRACTICE. 1. Differentiate between acute alcoholism and apoplexy. 2. Give etiology, physical signs, and treatment of peri- carditis. 3. Give physical signs of acute lobar pneumonia. 4. Give etiology, diagnosis, and treatment of biliary colic. 5. What are the two common complications of typhoid fever during the second or third week? and give treat- ment. 6. Describe a case of acute catarrhal dysentery and give treatment. 7. Give etiology, diagnosis, and treatment of gon- orrhea. 8. Give diagnosis and treatment of acute articular rheu- matism. 9. Give etiology, morbid anatomy, period of measles in- cubation, common complications and their treatment. 10. Describe three stages of malarial paroxysm and give treatment in each stage. SURGERY. 1. Describe symptoms and operation for gallstones. 2. Through what would you pass, in the open method of operating for hydrocele? 3. What are the contraindications for hemorrhoidal operation? 4. How would you differentiate between gallstones, gas- tric ulcer, and appendicitis? 5. Give surgical treatment for Bright's disease. OBSTETRICS. 1. Describe the Fallopian tubes. 2. Describe the placenta and give its functions. 3. Give differential diagnosis of pregnancy from ovar- ian cystoma. 4. Give treatment for threatened abortion. 5. Write prescription for vaginitis. 6. Give treatment for placenta prsevia. 7. What are the indications for vaginal tamponing? 8. Give method of performmg Gephalic version. 9. Give treatment of uterine inertia. 10. Give management of normal labor. 43 MEDICAL RECORD, ANSWERS TO S'TATE BOARD EXAMINATION QUESTIONS. Arkansas State Board of Medical Examiners. anatomy. i. Hair begins to develop at about the third month of fetal life. 2. Bones are classified as: (i) Long, (2) short, (3) flat, and (4) irregular bones. 3. -Scapula, clavicle, humerus, ulna, radius, carpal (scaph- oid, semilunar, cuneiform, pisiform, trapezium, trapezoid, os magnum, unciform), five metacarpals, and fourteen phalanges. 4. The diaphragm is a musculofibrous septum which di- vides the thoracic from the abdominal cavity; it is fan- shaped; the broad, elliptical portion is horizontal, and the crura are vertical. It is attached to the ensiform, to the internal surfaces of the lower six costal cartilages, to bodies and intervertebral substances of first, scond, and third lumbar vertebrae. Its openings are: (1) The aortic, (2) the esophageal, (3) the opening for the vena cava, (4) the right crural, (5) the left crural. Nerve supply: Phre- nic, lower intercostal, and sympathetic. Action: It is the chief inspiratory muscle; also used in all expulsive ef- forts (laughing, sneezing, coughing, crying, vomiting, urin- ation, defecation, and parturition). 5. External oblique, internal oblique, transversalis, rec- tus, pyramidalis. 6. Openings of superior vena cava, of inferior vena cava, of coronary sinus, of foramina of Thebesius, right auriculo- ventricular, of pulmonary veins, left auriculo-ventricular, of pulmonary artery, and of aorta. 7. Anterior and posterior recurrent tibial, superior fibular, muscular, external, and internal malleolar. 8. See Cunningham's "Anatomy" (1909), page 603; or Gray's "Anatomy" (1908), page 980. 9. See Cunningham's "Anatomy" (1909), page 1187; or Gray's "Anatomy" (1908), page 1498. 10. See Cunningham's "Anatomy" (1909), page 11 18; or Gray's "Anatomy" (1908), page 1350. PHYSIOLOGY. 1. Lieberkiihn's glands are found throughout the small and large intestine; Brunner's glands are found in the duodenum; the solitary glands are found throughout the entire intestine, but are most abundant in the lower part of the ileum and the upper part of the large intestine; Peyer's patches are found in the lower two-thirds of the small intestine, chiefly in the ileum. 44 MEDICAL RECORD. 2. Glycogen is chiefly formed from the carbohydrates. The liver cells act upon the dextrose into which the carbo- hydrates have been converted by the action of the ptyalin and amylopsin. This may occur by dehydration, but the exact process is not known. At a subsequent period the glycogen is transformed into dextrose and is returned to the circulation. Hence the blood of the hepatic veins contains more sugar than the blood of the arteries, and these latter more than the blood in the veins (except the hepatic). It is the generally accepted view, but it is de- nied by Pavy, and the whole subject is in a state of un- certainty. The destination of glycogen: It is converted into sugar (dextrose), is given off to the blood, and is finally oxidized in the tissues. 3. Fifth pair of cranial nerves. Origin: Superficial, from side of pons Varolii ; deep, from medulla, and floor of fourth ventricle. Distribution and Functions: First, ophthalmic; sensory to anterior half of scalp, conjunctiva, and skin of upper eyelid, cornea, skin of nose, mucous membrane of nose, lacrymal gland. Second, superior max- illary; sensory to conjunctiva and skin of lower eyelid, nose, cheek, upper lip, palate, upper teeth, and alveolar processes. Third, inferior maxillary; sensory to external auditory meatus, side of head, mucous membrane of mouth, anterior two-thirds of tongue, lower lip, teeth and alveolar processes of lower jaw. It is also motor to the muscles of mastication (temporal, masseter, two pterygoids), mylo- hyoid, and anterior belly of the digastric. 4. See Cunningham's "Anatomy" (1909)* page 443; or Gray's "Anatomy" (1908), page 815- 5. See Cunningham's "Anatomy" (1909), page 607; or Gray's "Anatomy" (1908), page 982. CHEMISTRY. 1. Albumin is a protein substance, found in most ani- mal tissues, and consisting of carbon, hydrogen, oxygen, nitrogen, and sulphur. It is soluble in pure water, and is coagulated by heat. 2. In the white of hen's egg. 3. and 4. In mercurial poisoning (by corrosive sub- limate), also in poisoning by nitrate of silver. 5. By toxicology is meant that branch of medical science which appertains to poisons ; it includes their char- acter, origin, actions, symptoms produced, antidotes, treat ment, and detection. 6. The process of slow oxidation. 7. By ptomain poison is meant the poisonous products of putrefaction of dead animal tissues and fluids. 8. Ptomains are derived from dead animal matter. 45 3 MEDICAL RECORD. 9. By the action of plants : the chlorophyl of which, under the influence. of sunlight, decomposes the C0 2 into C and Oi. The plants retain the carbon in organic combina- tion, and return the oxygen to the air. MATERIA MEDICA AND THERAPEUTICS. 1. An alkaloid is an organic, nitrogenized substance, alkaline in reaction, and capable of combining with acids to form salts in the same way that ammonia does. A tincture is an alcoholic solution of a nonvolatile substance. A fluid extract is a permanent solution of a vegetable drug, in which one cubic centimeter of the solution represents one gram of the drug. 2. (1) Emetics, as tartar emetic, dose one to two grains; (2) diuretics, as potassium acetate, dose five to sixty grains; (3) hypnotics, as chloral hydrate, dose five to twenty grains; (4) mydriatics, as atropine sulphate, dose one one-hundred-and-twentieth to one-twentieth of a grain. 3. To stimulate the heart's action, strychnine; to pro- duce emesis, apomorphine; to control hemorrhage, ergot. 4. Normal salt solution is of the strength of 0.7 of 1 per cent. It is indicated in shock or hemorrhage, as an irri- gating fluid, and for intravenous infusion. For method see Rose and Carless' "Surgery" (1907), pages 260, 977, and 2J7 ; or Da Costa's "Surgery" (1908), pages 241 and 242. 5. Principal alkaloid of belladonna is atropine; dose, gr. 1/160. Indications : To relieve pain, relax spasms, to check secretions, to dilate the pupil, to prevent the griping of purgatives, in urinary incontinence, in inflammatory conditions, in asthma, whooping cough, and for the night sweats of phthisis. 6. Pulvis ipecacuanhse et opii, ten grains; tinctura opii, about ten minims ; tinctura opii camphorata, about half an ounce. 7. Sulphate of strychnine, gr. 1/90; sulphate of atropine, gr. 1/200; sulphate of morphine, gr. 1/6; apomorphine hydrochloride, gr. 1/12 ; nitroglycerin, Tl# % ; pilocarpine hydrochloride, gr. 1/6. 8. 5 Potassii acetatis Potassii bitartratis Potassii citratis a a 3ij Aquae destillatae q.s ad Sviij. Misce. Signa : One tablespoonful three times a day, in half a glass of water. 9. Salines cause a great increase in the amount of fluid secreted by the intestinal glands; they also hinder the re- absorption of this fluid. The result is an accumulation of 46 MEDICAL RECORD fluid in the intestine, which, by distention, excites peri- stalsis. \g) Xitrite of amyl is inhaled; it is kept in pedes, which are crushed when required. It is used to dilate the blood- vessels in angina pectoris, epilepsy, cardiac dyspnea. PRACTICE. i. See French's "Practice of Medicine" (1907), pages 954 and 1076. 2. See French's "Practice of Medicine" (1907), page 557; or Osier's "Practice of Medicine" (1909), page 775. 3. See French's "Practice of Medicine" (1907), page 158; or Osier's "Practice of Medicine" (1909), page 175. 4. See French's "Practice of Medicine" (1907), page 850; or Osier's "Practice of Medicine" (1909), page 550. 5. Hemorrhage and perforation of intestines. See French's "Practice of Medicine" (1907), pages 117 and 118; or Osier's "Practice of Medicine" (1909), page 103. 6. See French's "Practice of Medicine" (1907), page 225; or Osier's "Practice of Medicine" (1909), page 244. 7. See French's "Practice of Medicine" (1907), page 214; or Osier's "Practice of Medicine" (1909), page 281. 8. See French's "Practice of Medicine" (1907), page 228] or Osier's "Practice of Medicine" (1909), page 225. 9. See French's "Practice of Medicine" (1907), page 326: or Osier's "Practice of Medicine" (1909), page 141. 10. See French's "Practice of Medicine" (1907), pages 242 and 248; or Osier's "Practice of Medicine" (1909), pages 16 and 24. SURGERY. i. See Rose and Carless' "Surgery" (1908), pages 1059 and 1061 ; or Da Costa's "Surgery" (1908), pages 891, 894, and 965. 2. Skin, dartos, intercolumnar fascia, cremasteric fascia, infundibuliform fascia, and the parietal layer of the tunica vaginalis. 3. Contraindications for hemorrhoidal operation: Can- cer, or other serious rectal disease; hepatic or cardiac dis- ease, as the cause of the hemorrhoids. 4. In gallstones there is excruciating pain in the right hypochondrium and epigastrium, muscular rigidity, vomit- ing, jaundice, and fever. In gastric nicer the pain is not so severe, is in the epigastrium, begins soon after eating ; there is no rigidity and no fever. In appendicitis: "There is no initial rise of temperature, the latter usually appearing after a few hours. The vomit- ing in biliary colic immediately follows the onset, and not after a few hours, as in appendicitis. It is also more fre- quent during the continuance of the pain in biliary colic. 47 MEDICAL RECORD. The pain in the latter is more severe than in appendicitis, is located higher in the abdomen, as a rule, and radiates to the right shoulder. The muscular rigidity and tender- ness are also higher, being most marked just beneath the costal arch. Appendicitis and chol lithiasis at times co- exist, so that the clinical picture is a most confusing one." — (Eisendrath.) 5. See Rose and Carless' "Surgery" (1908), page 1166; or Da Costa's "Surgery" (1908), page 11 16. OBSTETRICS. 1. See Cunningham's "Anatomy" (1909), page n85; or Gray's "Anatomy" (1908), page 15 10. 2. At full term the placenta is a soft, spongy mass, roughly saucer-shaped, from six to nine inches in diameter, about three-quarters of an inch in thickness at the central point, and weighs about one pound. Its functions are: (1) To supply nourishment to the fetus; (2) to act as a respiratory organ for the fetus; (3) to act as an excretory organ for the fetus. 3. Differential diagnosis— Pregnancy: The tumor is hard and does not fluctuate, is situated in the median line, and may give fetal heart sounds and movements; the cer- vix is soft, and the other signs of pregnancy are present. The rate of growth of the tumor, and the general condition of the patient's health may also help in arriving at a diagnosis. Ovarian cystoma: Absence of the chief signs of preg- nancy; there may be the characteristic facies, the tumor is soft, fluctuating, is more to one side, and does not show fetal signs. 4. See Williams' "Obstetrics" (1909), page 618; or Hirst's "Obstetrics" (1909), page 280. 5. I£. Acidi borici. Sodii bicarbonatis aa, Jj. M. Signa : Put two teaspoonf uls in douche bag of hot water and use as douche morning and evening. 6. See Williams' "Obstetrics" (1909), page 815; or Hirst's "Obstetrics" (1909), page 577- 7. For controlling hemorrhage, either vaginal or uterine ; to exert pressure ; to support the uterus ; as a means of applying medication locally; and for depleting inflamma- tory conditions. 8. See Williams' "Obstetrics" (1909), page 434; or Hirst's "Obstetrics" (1909), page 414. 9. See Williams' "Obstetrics" (1909). page 661; or Hirst's "Obstetrics" (1909), page 442. 10. See Williams' "Obstetrics" (1909), page 225; or Hirst's "Obstetrics" (1909), page 324. 48 MEDICAL RECORD. STATE BOARD EXAMINATION QUESTIONS. California State Board of Medical Examiners. ANATOMY. (Answer ten questions only.) 1. Trace cerebrospinal fluid from the lateral ventricles to the spinal canal. 2. Describe the rami communicantes. 3. Name the bones of the tarsus ; use diagram. 4. Indicate, on the diagram, the points of exit from the pelvis of the following nerves; external cutaneous, an- terior crural, genitocrural, obturator, sciatic, pudic, superior gluteal. 5. Indicate, on the diagram, the course of the common, internal, and external iliac arteries. 6. What veins are without valves? 7. What cranial nerves are distributed to muscles only, i.e. are motor? 8. Give topographical outline of the lungs and bronchi on the anterior chest wall ; use the diagram. 9. Give origin and course of the eleventh cranial nerve as far as its exit from the skull. 10. What are the characteristics of arthrodial joints? Give five examples of this class of joints. 11. What is the ischiorectal fossa, how bounded, and what does it contain? 12. When the arm is hanging with palm forward, what bony prominences at shoulder, elbow, and wrist are nor- mally in line? HISTOLOGY. (Answer eight written questions and identify slides.) 1. (a) Name the structures found in red bone marrow; (b) give the function of red bone marrow. 2. Draw diagram illustrating long tissue, naming differ- ent structures. 3. Explain the difference between the mucosa of the endometrium and that of the vaginal portion of the cervix. Also make drawing. 4. Give structure of the tonsil. 5. From which germ layers are the following derived? Pancreas, spleen, large intestine, salivary glands, fat. 6. Draw a transverse section of the brain, at a point just anterior to the pons varolii. Name most important parts. 7. Draw diagram illustrating a cell and name all the necessary constituents. 8. Describe the structure of the liver. 49 MEDICAL RECORD. 9. Explain the difference between the white and gray matter of the brain. 10. What are terminal arteries? Name organs which are so supplied. 11. Identify slides. 12. Identify slides. PHYSIOLOGY. (Answer ten questions only.) 1. How and where is lymph formed? 2. Discuss sleep and its causation. 3. Discuss briefly the influence of the nervous system on the digestive secretions. 4. Describe the movements of the intestines during diges- tion. 5. Explain the effect of (a) expiration on the volume of the brain, (b) inspiration. 6. Discuss the formation, function, and fate of glycogen. 7. What is the physiological difference between the brain of man and that of lower animals? 8. Under what circumstances may functional union be made between fibers of different nerve trunks? What practical value has this operation? 9. Give nerve supply and action of muscles concerned in the movements of the eyeball. 10. Do we determine the function of a nerve by the location or function of the center from which it comes or by its peripheral connections? Give your reasons. 11. What is the effect of a destructive lesion in the posterior limb of the internal capsule? 12. To what extent is the secretion of sweat under (a) nervous control; (b) vascular control? BACTERIOLOGY. (Answer eight questions only.) 1. What are the differences in structure, methods of multiplication sporulation, etc., between the blastomycetes or yeasts and bacteria? 2. What changes are produced on the culture media when Bacillus Coli Communis is grown: (a) upon gelatin, (b) in milk, (c) in dextrose, (d) in lactose? 3. Describe the conditions necessary to successfully grow Bacillus tetani and the appearance of a stab culture in agar or gelatin about the sixth day. 4. What is the difference between an antitoxin and a bacterial vaccine? 5. Name four (4) pathogenic anerobic bacteria. 50 MEDICAL RECORD. 6. Differentiate between bacillus tuberculosis and bacillus leprae, taking into consideration staining, culture peculiari- ties, effect on tissues, and relation to tissue cells of the host. 7. Describe briefly how you would make gelatin plate cultures, using material from a furuncle as the source from which to obtain the germ. 8. Name ten (10) pathogenic bacteria that are Gram positive. 9. What do you understand by the opsonic index? 10. How would you sterilize: (a) a culture tube of gelatin, (b) a p"lass container with rubber stopper, (c) a platinum needle in a glass handle? 11. Identification of cultures. 12. Identification of slides. CHEMISTRY. (Answer ten questions only.) 1. What is the poison in most headache powders? Its effect? Antidote. 2. Mention six elementary substances commonly used in their pure state in medicine. 3. What does the presence of an abnormal quantity of chlorine in drinking water indicate? 4. How would you detect the presence of bile in the urine? Give two tests. 5. Give the reaction, specific gravity, and percentage of fats in normal cow's and woman's milk. 6. Mention a secretion in the body that contains choles- terin; one that contains pepsin, and one that contains trypsin. 7. What antidotes should be used in phosphorus poison- ing? Explain the action of each. 8. Define and illustrate (a) capillary attraction, (b) absorption, (c) diffusion, (d) osmosis, (e) endosmosis. 9. In what principal form is nitrogen eliminated from the body? Give the chemical properties of nitrogen. 10. What is the -chemical composition of the various renal calculi? 11. Mention one chemical antidote for each of the fol- lowing: (a) Phenol, (b) arsenious oxide, (c) sulphuric acid, (d) mercuric chloride, (e) oxalic acid. 12. What are the distinguishing characteristics of urates and uric acid as found in the urine? Give test for uric acid. GENERAL DIAGNOSIS. (Answer ten questions only.) 1. Give the physical signs of a pleurisy with effusion. 2. Give the symptoms of bubonic plague. 51 MEDICAL RECORD. 3. Give the symptoms and physical signs of aortic in- sufficiency in the stage of failing compensation. 4. Give varieties, etiology, and symptoms of chorea. 5. Give the symptoms of tabes dorsalis. 6. Describe a Colles' fracture. 7. Give the points upon which you would make a diag- nosis of cancer of the stomach. 8. Describe diabetes mellitus, and differentiate it from diabetes insioidus. 9. Differentiate rubeola from scarlet fever. 10. Describe the secondary lesions of syphilis. 11. Give the symptoms of a transverse myelitis. 12. Give the symptoms of cholelithiasis. PATHOLOGY. (Answer eight of the written questions and identify four slides. ) 1. Describe the difference in the pathological changes which take place in degeneration of the tissues and those which take place in atrophy. 2. Give the pathology of tabes dorsalis. 3. Describe the gross and microscopic changes which take place in the spleen, liver, and kidneys as a result of prolonged exposure to malarial infection. 4. What are the postmortem changes usually found in diabetes mellitus in (a) children, (b) adults of middle age, (r) adults of advanced age? 5. What is the average blood pressure in adults fifty to sixty years of age measured in millimeters of mercury? Describe the results if this pressure is exceeded for a con- siderable time. 6. In bony tissue what variety of malignant growths usually occur, and why? 7. Under what conditions is cerebral embolism most likely to occur? What blood-vessels are most likely to be affected, and why? 8. Describe the local lesion caused by infection by anthrax bacilli; the general or systemic effects, and state how infection usually occurs. 9. Describe the condition present in acute dilatation of the heart. Give the immediate and predisposing causes and the usual final result. 10. State fully why urinary bladder disorders are so fre- quent and so resistant to treatment in both elderly men and elderly women. 11. Identify two slides. 12. Identify two slides. 52 MEDICAL RECORD OBSTETRICS. (Answer ten questions only.) i. What zymotic diseases are liable to affect the pregnant and puerperal woman, and how? 2. How soon after the completion of the second stage of labor should the umbilical cord be ligated? How dressed? What are the dangers of improper dressing? 3. What injuries are liable to occur to the birth canal during labor? 4. Under what circumstances are anesthetics indicated in labor? What are the dangers? 5. What are the causes of premature rupture of the membranes? How does it influence the progress of labor? 6. How would you determine if a child is premature at birth? _ 7. Differentiate between retained and adherent placenta; the management of each. 8. What can be determined by external palpitation of the pregnant woman at the eighth month? How should it be performed? 9. What are the so-called false pains of labor? Differen- tiate from true pains. 10. Rupture of the uterus ; etiology and symptoms. 11. Give the physiology of menstruation; of ovulation; relation, if any. 12. What is inversion of the uterus? Diagnosis and management. GYNECOLOGY. (Answer ten questions only.) 1. Give the conditions justifying operative measures in fixed retrodisplacement of the uterus. 2. Describe a pelvic hematocele, and give the usual cause. 3. What is the pathology of pelvic cellulitis, and what are the physical signs? 4. Name the most important causes of sterility. 5. Differentiate between a pudendal hernia and pudendal hematocele. 6. What do you understand by the operation for peri- neorrhaphy? 7. Give the etiology and pathology of chronic endocer- vicitis? 8. Describe a case of carcinoma uteri, and give some of the most prominent physical signs. 9. Discuss the matter of relative protmosis^ of cancer of che body of the uterus and cancer of the cervix. 53 MEDICAL RECORD. io. Describe the mode of use and purpose of a vaginal tampon. ii. Differentiate between herpes of the vulva and chancre. 12. Name the muscles of the perineum, and give the functions or the perineal body. HYGIENE. (Answer ten questions only.) i. Describe in detail the method of transmission of yellow fever. 2. What measures would you adopt to prevent the spread of typhoid fever during an epidemic? 3. What is a septic tank? Describe construction and explain how it acts. 4. What sanitary measures should be adopted in caring for tuberculous patients? 5. Name five of the most common intestinal parasites, and give a short description of each. 6. Give three ways of fumigating a room with formalin ; also two methods with other disinfectants. 7. What effect have venereal diseases on the propagation of the human species? Explain. 8. How does the hookworm usually enter the human body? What means would you adopt to prevent its spread? 9. Describe the technique of vaccination, and give the course of a successful case. 10. What is the period of incubation of the following diseases: Plague, smallpox, diphtheria, scarlatina, measles? 11. What is the object of placing traps on all waste pipes? What danger to health would arise if there were no traps? 12. Describe two types of water filter. What should be accomplished by a good filter? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. California State Board of Medical Examiners. ANATOMY. i. The cerebrospinal fluid passes from the lateral ventri- cles through the foramen of Monro into the third ventri- cle; then through the aqueduct of Sylvius (or iter a tertio ad quartum ventriculum) into the fourth ventricle, through the latter, and into the central canal of the spinal cord. 2. See Cunningham's "Anatomy" (1909), pages 615, 616, 54 MEDICAL RECORD. and 609; or Gray's "Anatomy" (1908), pages 1078 and 1079. 3. The bones of the tarsus are: Calcaneus, astragalus, cuboid, scaphoid, internal cuneiform, middle cuneiform, and external cuneiform. For diagram, see Cunningham's "Anatomy" (1909), page 239; or Gray's "Anatomy" (1908), page 242. 4. See Cunningham's "Anatomy" (1909), page 641; or Gray's "Anatomy" (1908), pages 1017 and 1029. 5. See Cunningham's "Anatomy" (1909), pages 840 and 857; or Gray's "Anatomy" (1908), pages 671 and 686. 6. The veins without valves are : The venae cavse, hepatic veins, portal vein and its branches, renal, uterine, ovarian, pulmonary, cerebral, spinal, and umbilical veins. The sinuses of the skull and very small veins are also without valves. 7. The cranial nerves exclusively motor are: Oculomotor (3) ; Trochlear (4) ; Abducens (6) ; Facial (7) ; Spinal ac- cessory (11) ; and Hypoglossal (12). 8. See Cunningham's "Anatomy" (1909), page 1257. 9. See Cunningham's "Anatomy" (1909), page 695; or Gray's "Anatomy" (1908), page 1073. 10. See Cunningham's "Anatomy" (1909), page 257; or Gray's "Anatomy" (1908), page 268. 11. See Cunningham's "Anatomy" (1909), page 1281 ; or Gray's "Anatomy" (1908), page 1548. 12. When the arm is hanging with palm forward the acromion process of the shoulder, the external condyle of the humerus, and the styloid process of the radius are normally in line. HISTOLOGY. 1. (a) See Cunningham's "Anatomy" (1909), page 71; or Gray's "Anatomy" (1908), page s^> ( ] °) The function of red bone marrow is to form red blood corpuscles; also to help in the formation of bone. 2. See Cunningham's "Anatomy" (1909), page 990; or Gray's "Anatomy" (1908), page 1403. 3. See Cunningham's "Anatomy" (1909), page 1191; or Gray's "Anatomy" (1908), page 1504. 4. See Cunningham's "Anatomy" (1909), page 1035; or Gray's "Anatomy" (1908), page 1223. 5. Pancreas is derived from entoderm; spleen, from mesoderm; Large intestine, from entoderm; Salivary glands, from ectoderm ; Fat, from mesoderm. 7. See Cunningham's "Anatomy" (1909), page 8. 8. See Cunningham's "Anatomy" (1909) page 1121; or Gray's "Anatomy" (1908), page 1345. 9. See Cunningham's "Anatomy" (1909), page 443; or Gray's "Anatomy" (1908), page 833. 55 MEDICAL RECORD. io. Terminal arteries are such as do not anastomose with other arteries, either directly or by branches. Organs supplied with terminal arteries: Retina, brain, kidneys, spleen, lungs. PHYSIOLOGY. i. There are two theories as to the formation of lymph: (i) That it is formed from the blood plasma by the processes of filtration, diffusion, and osmosis. (2) That in addition to these -the endothelial cells of the capillaries exercise some influence. 2. Sleep is a condition of partial or complete uncon- sciousness, during which the brain and body can recuperate. Metabolism in general is diminished, anabolism is (rela- tively) in excess of katabolism. During sleep the respira- tions are slower and deeper, most of the secretions are diminished, the pulse is slower, the eyeballs roll inward and upward, and oxidation in the tissues is decreased. The cause of sleep is not known. Bradbury (in Allbutt's "System of Medicine") gives the following as hypotheses as to the causation of sleep: (1) Cerebral anemia; (2) chemical changes in the brain cells or neurons, such as an exhaustion of their intramolecular oxygen, or an accumula- tion of fatigue products; (3) contraction of the dendritic processes and a consequent break in the transmission of nerve impulses ; (4) expansion of the neuroglial cell proc- esses, insulating the nerve processes and producing the same effect; (5) loss of consciousness apart from any physical or chemical change ; (6) the most probable hypoth- esis is that of an altered metabolism of the cerebral^ cells dependent upon exhaustion and diminished influx of stimuli. Quite recently two new theories have been promulgated; one attributes the causation of sleep to an internal secre- tion of the pituitary body; the other makes it due to osmosis. 3. "The secretion of the digestive fluids is governed by the action of the nervous system, so that they are poured into the alimentary canal during the digestive process as they are required. The saliva is continuously secreted in sufficient quantities to keep the mouth moist, but _ the quantity formed is greatly increased by the sight or idea of food, as well as by the actual presence of food in the mouth, or the savory smell of food acting on the olfactory nerve. "Stimulation of the mucous membrane of the stomach gives rise to increased vascularity, also to a copious secre- tion of gastric juice. It is probable that the food acts directly upon a local nervous mechanism in the wall of the stomach, possibly Meissner's plexus, yet it is certain 56 MEDICAL RECORD. that the secretion of the gastric fluid is more or less under the influence of the central nervous system. ^ This is seen in the manner in which the digestive function is arrested by fear, anger, and other mental conditions. Moreover, the secretion of the gastric juice commences before food is actually introduced into the stomach, as the smell, taste, or idea of food stimulates its glands to activity. As division of the vagus below the origin of the recurrent branch during digestion causes the gastric mucous membrane to become pale, and diminishes the secretion of gastric juice, it may be inferred that this nerve is an efferent nerve, the action of which normally inhibits the vasoconstrictor action of the sympathetic. "The secretion of the pancreas, like that of the salivary glands, is undoubtedly under the control of the nervous system, and a large flow of pancreatic juice occurs imme- diately food is taken; and a second but less copious flow takes place about four hours afterwards, probably when the principal discharge of chyme from the stomach into the duodenum takes place. "In the intestine the rich nervous plexus of Meissner, which is found in the submucous tissue, is concerned in regulating the secretion of the glands in the intestinal wall. Similar plexuses are found in the esophagus and stomach, and in the latter, it has been already stated, a local nerv- ous mechanism probably regulates the act of secretion." — (Aids to Physiology.) 4. See Gray's "Anatomy" (1908), page 1330. 5. The volume of the brain is increased during expira- tion, and is diminished in inspiration. This can be ob- served in infants before the fontanelles are closed, and in adults when the brain is exposed. "With the act of ex- piration the flow of blood in the arteries is favored and the current in the veins is retarded. If the effort be vio- lent, the valve at the opening of the internal jugular maybe closed. This act would produce an expansion of the brain, not from reflux by the veins, but from the fact that the flow into the chest is impeded, and the blood, while passing in more freely by the arteries, is momentarily confined. With inspiration the flow into the thorax is materially aided, and the brain is in some degree relieved of this expanding force."— (Flint's Physiology.) 6. Glycogen is chiefly formed from the carbohydrates. The liver cells act upon the dextrose into which the carbo- hydrates have been converted by the action of the ptyalin and amylopsin of the digestive juices. This may occur by a simple process of dehydration : C6H12U6 — H 2 = CsHioOs 57 MEDICAL RECORD. But the precise process by which it occurs in the liver cells is not known. At a subsequent period the glycogen is transformed into dextrose and is returned to the cir- culation. Hence the blood of the hepatic veins contains more sugar than the blood of the arteries, and these latter more than the blood in the veins (except the hepatic). This is the generally accepted view, but it is denied by Pavy, and the whole subject is in a state of uncertainty. The function of glycogen is to form a temporary re- serve supply of carbohydrate material that is stored up in the liver during digestion, and made use of between meals ; at the same time the percentage of sugar in the systemic blood is kept nearly constant. 7. The brain of man, as compared with that of lower animals: (1) Is greater in size and weight; (2) shows a greater complexity of the convolutions; (3) has frontal lobes relatively greater in size and complexity; (4) has temporo-sphenoidal lobes less prominent; (5) the fissure of Sylvius is nearly horizontal; and (6) the fissure of Rolando is more distinct. — (From Kirkes' Physiology.) 8. This procedure is of very limited application because of the necessity of finding large nerves in the neighbor- hood; it is utilized nearly exclusively in the upper extrem- ity; it seems to make no difference whether a sensory nerve be grafted to a motor or to a mixed nerve — or vice versa. The object is to switch an interrupted nerve impulse into a neighboring sound nerve, and then have it returned to the original nerve (lower down), and so transmitted to its final distribution as though there had been no interruption. 9. See Cunningham's "Anatomy" (1909), page 401; or Gray's "Anatomy" (1908), page 376. 10. The function of a nerve is determined by dividing the nerve and then observing whether there is any loss of sensation, or muscular paralysis, or absence of secretory function, or degeneration of tissue. 11. A destructive lesion in the posterior limb of the in- ternal capsule will cause hemiplegia of the opposite side, followed by contractures ; and also hemianesthesia, in which the special senses may be included. 12. (a) The secretion of sweat is chiefly under nervous control; and (b) but slightly under vascular control. "The relation of the secretion of perspiration to the temperature of the body, and the amount formed, is under the control of the nervous system. An increased supply of blood to the skin, the result of vasomotor inhibition, acts only in- directly in increasing the secretion, which is under the direct control of special secretory nerves. This can be shown by the stimulation of a cutaneous nerve even after 58 MEDICAL RECORD. the blood supply has been cut off. Stimulation of the sciatic of the amputated limb of an animal will produce a discharge of sweat upon the foot. The copious sweat produced on the pale, cold, anemic skin by fear and in some forms of death are evidence that sweat, like saliva, may be secreted in considerable quantity without any in- creased, and, indeed, with a greatly diminished, blood sup- ply." — (Aids to Physiology.) BACTERIOLOGY. i. Blastomycetes. Structure: A protoplasmic body sur- rounded by a double-contoured capsule. Sometimes drops of fat, granules, and vacuoles are seen ; the presence of a nucleus is doubtful. Sometimes they appear as long, cylin- drical hyphce. Multiplication is by budding; sometimes also by sporulation. Bacteria. Structure: A protoplasmic body surrounded by a cell wall and nucleated, often flagellated, and some- times granular. Multiplication is by fission, sometimes also by sporulation. 2. Bacillus coli communis (a) shows colonies in twenty- four hours on gelatin. The deeper colonies are round and brownish ; the more superficial ones are larger and more diffuse ; the edges are dentate ; the gelatin is not liquefied. (b) The milk coagulates, becomes acid, gas is given off, and a fecal odor is observed, (c) Dextrose is fermented, and gases are formed (mainly C0 2 and H 2 , generally two parts of H 2 to one of CO2). (d) Lactose is fermented, and gases are formed (mainly C0 2 and H, but in less constant proportion than in dextrose). 3. Absence of oxygen is necessary for the growth of the tetanus bacillus ; otherwise the conditions are much the same as for other bacilli. The appearance of a stab cul- ture, in gelatin, about the sixth day, is that of a fir tree. 4. Difference between an antitoxin and a bacterial vac- cine: ''The antitoxic sera act directly upon the poison secreted by the living bacterial cell and neutralize its toxic property, while the bacteriolytic sera affect the bacteria themselves and destroy them or paralyze their action. Since the antibacterial sera are without effect upon the formed toxin, they are mainly useful in practice as a means of protecting against the bacterial invasion, while the antitoxic sera {e.g. diphtheria) may be employed to combat an infection already in progress. Broadly speak- ing, the latter are curative, the former protective." — (Jor- dan's Bacteriology.) 5. Four pathogenic anaerobic bacteria: Bacillus tetani, Bacillus cedematis maligni, Bacillus cerogenes capsulatus, and Bacillus botulinus. 59 MEDICAL RECORD 6. Differentiation between Bacillus tuberculosis and Bacil- lus leprae: (i) It is claimed that the leprosy bacillus is stained by an exposure of six or seven minutes to a cold, saturated, watery solution of fuchsin, and retains the stain when subsequently treated with acid alcohol (nitric acid i part to alcohol 10 parts). When treated for the same length of time the Bacillus tuberculosis does not ordinarily become stained. (2) The leprosy bacilli are found in enormous numbers, especially in large vacuolated cells (lepra cells), and lie in the lymph spaces. They are fre- quently beaded and lie in masses which have been likened to a bundle of cigars tied together. It is necessary to examine for long periods of time smears made from tuberculous lesions of skin before finding a single organ- ism. (3) Leprosy bacilli have not surely been cultivated. (4) Injected into guinea-pigs, they do not produce lesions. 7. To make a gelatin plate culture : Melt three tubes of gelatin, and let them cool in a water bath to about 30 C. Sterilize the platinum wire. Inoculate tube 1 with a platinum loopful of the material to be plated (pus from the furuncle) and mix thoroughly. Replace the cotton plug, and take care that it does not get soiled. From tube 1 transfer two loopfuls to tube 2, and mix, and replace plug as before. From tube 2 similarly transfer two loop- fuls to tube 3, and mix, and replace plug as at first. Then pour the contents of each tube into a sterile Petri dish; heat the neck of the tube as soon as the plug is removed, insert it under the edge of the lifted Petri di§h cover and pour quickly. 8. Ten pathogenic bacteria that are Gram positive: Staphylococcus pyogenes aureus, Staphylococcus pyogenes albus, Streptococcus pyogenes, Pneumococcus, Bacillus anthracis, Bacillus tuberculosis, Bacillus leprce, Bacillus diphtheria, Bacillus tetani, Micrococcus tetragenus. 9. The opsonic index is the relative amount of opsonins in a serum, as compared with the normal standard. It is obtained by dividing the average number of bacteria taken up by a leucocyte under the influence of a given serum by the average number taken up by a leucocyte under the in- fluence of a standard normal serum. 10. To sterilize (a) a culture tube of gelatin: Put it in an Arnold sterilizer on three successive days, or in the autoclave at about 8 or 9 pounds' pressure for ten minutes. (b) A glass container with rubber stopper: Take out the stopper, clean it with soap and water, and let it stand for an hour in a solution of bichloride of mercury 1 :iooo, and then wash with sterile water ; plug the glass with non- absorbent cotton and put it in a hot-air sterilizer at 170 C. for one hour, (c) A platinum needle in a glass handle: 60 MEDICAL RECORD Heat the needle in an alcohol flame till red hot, and then allow to cool. CHEMISTRY. i. The poison in most headache powders is Acetanilid. It produces a sense of chilliness, cold perspiration, cyanosis, pulse soft and slow, respirations slow and shallow, dizzi- ness, dyspnea, collapse, and coma. Antidote, strychnine. 2. Sulphur, mercury, phosphorus, oxygen, carbon, and iodine. 3. The presence of an abnormal quantity of chlorine in drinking water generally indicates sewage contamination. 4. Gmelin's test for bile pigments: Put 3 c.c. HN0 3 in a test tube, add a piece of wood, and heat until the acid is yellow; cool. When cold, float some of the urine to be tested upon the surface of the acid. A green band is formed at the junction of the liquids, which gradually rises, and is succeeded from below by blue, reddish-violet, and yellow. The Pettenkofer test: Dissolve one or two drops of a solution of cane sugar 1:4 in the liquid to be examined; shake the mixture and float it carefully upon concentrated H2SO4. In the presence of bile acids the solution becomes turbid at the zone of junction of the two layers; this is soon replaced by a deep reddish purple zone, which extends upward and downward. 5- Reaction Specific gravity — Percentage of fats. cow's MILK. Alkaline or ampho- teric. 1028 to 1034. 3 to 4. woman's milk. Alkaline or ampho- teric. 1026 to 1036. 3 to 4. 6. Cholesterin is found in the bile ; pepsin, in the gastric juice; trypsin, in the pancreatic juice. 7. In phosphorus poisoning the antidotes are: (1) Solu- tion of potassium permanganate (1 per cent.) ; this oxi- dizes the phosphorus, forming phosphoric acid and phos- phates; the potassium permanganate itself becoming man- ganese dioxide. (2) Old, acid, oil of turpentine; this is said to combine with the phosphorus to produce a non- poisonous substance. 8. (a) Capillary attraction is the force which attracts fluids in contact with small tubes thrust into them, so that the fluid is drawn up above the surface of the liquid in the containing vessel. (&) Absorption is the process by which one substance is taken up or into another by molecular action. 61 MEDICAL RECORD. (c) Diffusion is the gradual and spontaneous passage of one gas into another gas, or of one liquid or dissolved sub- stance into another liquid. (d) and (e) If two liquids be separated from each other by a membrane each will pass through the membrane into the other; this process is called osmosis; they do not pass with equal rapidity. Endosmosis is the term used to de- note the more rapid osmosis, and exosmosis, the slower. These terms are also used to denote the direction (inward or outward osmosis, respectively). 9. Nitrogen is chiefly eliminated from the body as urea. Chemical properties of nitrogen: It is a gas, colorless, odorless, tasteless; it is not combustible, and does not support combustion; is but slightly soluble in water; it is very slow to enter into combination ; it is not poisonous, but it is incapable of supporting respiration. 10. Chemical composition of various renal calculi: Uric acid, sodium urate, ammonium urate, calcium oxalate, cal- cium phosphate, ammonium magnesium phosphate; occa- sionally, cystin, xanthin, and urates of potassium, calcium, and magnesium. 11. Chemical antidote for (a) Phenol, sodium sulphate; (b) arsenious oxide, freshly prepared solution of ferric hydroxide; (c) sulphuric acid, magnesia; (d) mercuric chloride, white of egg; (e) oxalic acid, lime water. 12. Urates show a pinkish color, and dissolve on warm- ing the urine. Uric acid is recognized by its crystalline form, and by the murexide reaction. The murexide test is : Add a little dilute nitric acid to the urine, evaporate to dryness, a yellowish-red residue is left, add a few drops of ammonia, the residue turns to violet. This is due to the formation of murexide (or purpurate of ammonia). GENERAL DIAGNOSIS. i. See French's "Practice of Medicine" (1907), page 701 ; or Osier's "Practice of Medicine" (1909), page 646. 2. See French's "Practice of Medicine (1907), page 284; or Osier's "Practice of Medicine" (1909), page 240. 3. See French's "Practice of Medicine" (1907), page 585; or Osier's "Practice of Medicine" (1909), page 799. 4. See French's "Practice of Medicine" (1907), page 1 1 17; or Osier's "Practice of Medicine" (1909), page 1045. 5. See French's "Practice of Medicine" (1907), page 1047; or Osier's "Practice of Medicine" (1909), page 889. 6. See Rose and Carless' "Surgery" (1908), page 521; or Da Costa's "Surgery" (1908), page 506. 62 MEDICAL RECORD. 7. See French's "Practice of Medicine" (1907), page 759; or Osiers "Practice of Medicine" (1909)* page 485. 8. See French's "Practice of Medicine" (1907), pages 935, 943, and 947; or Osier's "Practice of Medicine" (1909), pages 408, 419, and 425. 9. See French's "Practice of Medicine (1907), pages 322, 323, and 330; or Osier's "Practice of Medicine" (1909)* pages 136, 137, and 144. 10. See French's "Practice of Medicine" (1907), page 421 ; or Osier's "Practice of Medicine" (1909), page 267. 11. See French's "Practice of Medicine" (1907), page 1030; or Osier's "Practice of Medicine" (1909), page 946. 12. See French's "Practice of Medicine" (1907), page 852; or Osier's "Practice of Medicine" (1909)* page 550. PATHOLOGY. 1. Degeneration is a pathological process in which ab- normal substances are formed within living cells, or the entire cells are transformed into abnormal material. Atrophy is decrease in the amount of a tissue, owing to diminution in size (simple atrophy) or number (numerical atrophy) of the histological elements of which it is com- posed. There are also loss of weight and impairment of function. There is no definite disease of the cells or tis- sues ; frequently the two conditions (degeneration and atrophy) merge, and it may be difficult to draw a dividing line between them. 2. In tabes dorsalis the posterior columns of the spinal cord and the posterior nerve roots are involved. The posterior columns of the spinal cord are gray and shrunken, and show considerable overgrowth of connective tissue in the columns of Goll, Burdach, and Lissauer; this process extends upward from the lumbosacral region ; the posterior nerve roots degenerate and become atrophic. The meninges over the affected parts become opaque and adherent. Some of the cranial nerves may also atrophy, notably the optic, but also the motor oculi and vagus. The process is de- structive and progressive ; it is not a simple wasting, although the nerve fibers are atrophied, but it is character- ized by irritation, changes in the axis cylinders, overgrowth of the connective tissue, and sometimes congestion; the spinal ganglia may be affected. 3. See French's "Practice of Medicine" (1907), page 239; or Osier's "Practice of Medicine" (1909), page 15. 4. For the changes, in general, see French's "Practice of Medicine" (1907), page 939; or Osier's "Practice of Medi- cine" (1909), page 412. As to the distinction asked in the question, we can find no information. 63 MEDICAL RECORD. 5. The average blood pressure in adults fifty to sixty years of age is about 100 to 145 mm. mercury. If this pres- sure is exceeded for a considerable time there will be hypertrophy and dilatation of the heart; possibly, also, bursting of a blood-vessel, with its consequences. 6. Sarcoma is the most usual malignant growth in bone; the reason is that bone is a connective tissue, and sarcoma is the only malignant tumor of the connective tissue type. 7. Cerebral embolism most frequently occurs as a result of vegetations of an endocarditis. The artery of the Syl- vian fissure is most likely to be affected, owing to anatom- ical conditions by which the embolus takes the most direct route from the left side of the heart to the brain (through the aorta, left common carotid, internal carotid, middle cerebral, and so to artery of Sylvian fissure). The anterior cerebral artery may also be obstructed; or the posterior cerebral (in which case the embolus travels along the vertebral and through the basilar). 8. See French's "Practice of Medicine" (1907), page 454; or Osier's "Practice of Medicine" (1909), page 252. 9. See French's "Practice of Medicine" (1907), page 599; or Osier's "Practice of Medicine" (1909), page 820. 10. In old age the walls of the bladder grow thicker, and the capacity becomes smaller; in men the prostate gland enlarges; urinary troubles follow, caused partly by the above and partly by diseases of the kidneys or other organs. All the resisting and recuperative powers of the body are diminished, the reparative processes no longer act, or act feebly and slowly; the nutrition of the tissues is enfeebled; hence diseases tend to become chronic. Degenerative proc- esses are also common. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), pages 480 and 916; or Hirst's "Obstetrics" (1909), pages 263 and 674. 2. There is no fixed time for the ligation of the cord; as a rule it should not be ligated till it has ceased to pul- sate, unless there is some urgent reason to the contrary. Dry, aseptic cotton or gauze (borated or salicylated) makes the best dressing. It should be kept dry and aseptic, and, if possible, be touched by no one but the physician. The dangers of improper dressing are : Infection, peritonitis, and death of the child. 3. Injuries which may occur to the birth canal during labor: Lacerated perineum, tears and abrasions of labia, injuries of blood-vessels, laceration of vagina, laceration of vulva, injuries to levator ani muscle, lacerations of 64 MEDICAL RECORD. cervix, rupture of uterus, instrumental perforation of uterus, inversion of the uterus. 4. Anesthetics are used in labor to lessen suffering produced by labor pains; to lessen the pain attending ob- stetric operations ; to relax the uterus when its rigid con- traction interferes with version; to promote dilatation of the os uteri; to reduce excessive nervous excitement which may interfere with progress of early stage of labor; to relieve eclamptic convulsions and mania ; in cases of uterine inversion to relax the constricting cervix and so facilitate replacement; in bipolar version to lessen pain of introduc- ing the hand into vagina ; in precipitate labor to suspend action of voluntary muscles and retard delivery; in all cutting operations upon the abdomen; and sometimes in sewing up a lacerated perineum when many sutures are required. — (From King's Obstetrics.) Dangers: It lessens the efficiency of the uterine con- tractions ; it predisposes to postpartum hemorrhage ; and, if given too freely, may be followed by headache, nausea, and vomiting. 5. Premature rupture of the membranes. Causes: Deformed pelvis, shoulder presentation, unusual friability of the membranes, endometritis. The progress of labor is lengthened and rendered more difficult; hence infection is more likely. It conduces to laceration of the cervix, rup- ture of cervix, prolapse of funis, maternal exhaustion and shock, and fetal death. 6. See Williams' "Obstetrics" (1909), page 146; or Hirst's "Obstetrics" (1909), page 86. 7. Adherent placenta is not common. It cannot be ex- pressed. There is no descent of the cord. Pressure on the fundus causes a thrill of the cord; there is hemorrhage. In retained placenta the opposite of the above will be observed. For treatment see Williams' "Obstetrics" (1909), page 301; or Hirst's "Obstetrics" (1909), pages 434 and 436. 8. See Williams' "Obstetrics" (1909), page 211 ; or Hirst's "Obstetrics" (1909), pages 200 and 389. 9. False pains are irregular uterine contractions which occur before the beginning of labor, and which may be either painful or painless, and which do not cause the "show," nor yet dilate the os. True pains are uterine contractions occurring at the be- ginning and lasting through the first two stages of labor. They are usually very painful; they advance labor, dilate the os, and cause the "show." 10. See Williams' "Obstetrics" (1909), pages 833 and 836; or Hirst's "Obstetrics" (1909), pages 593 and 597. 65 MEDICAL RECORD. ii. See Williams 5 "Obstetrics" (1909), page 81; or Hirst's "Obstetrics" (1909), pages 57 and 61. The relation existing between ovulation and menstrua- tion is not known. The two processes are usually coexist- ent, but they may be independent of each other. The fol= lowing theories have been held*: (1) Menstruation is de- pendent upon ovulation; (2) ovulation is dependent upon menstruation; (3) they are independent of each other; (4) they both depend upon some other (at present unknown) cause. 12. See Williams' "Obstetrics" (1909), page 824; or Hirst's "Obstetrics" (1909), pages 614 and 616. GYNECOLOGY. 1. "Many cases of displacements are so complicated by prolapsed and adherent^ ovaries, by advanced disease of the ovaries and Fallopian tubes, by tumors, by inflam- matory exudates, or by peritoneal adhesions that replace- ment is impossible, or, replacement being possible, the pessary is either intolerable from pain or proves inadequate to sustain the uterus. Such cases, unless relievable by non- surgical measures, furnish a definite indication for sur- gical treatment." — (Dudley's Gynecology.) 2. Pelvic hematocele is an accumulation of blood in the pelvis, due to rupture of a blood-vessel ; it is generally due to rupture of a tubal pregnancy, or to a tubal abortion. Symptoms: Pain, which is sudden and severe, over abdo- men and pelvis ; nausea, cold perspiration, cold extremities, pulse rapid and weak, pinched features, and shock. 3. Pelvic cellulitis. Pathology: "Pelvic cellulitis is the inflammation of the connective tissue in the pelvis, above the pelvic diaphragm. It is particularly found in the broad ligaments, the surroundings of the cervix, and the sacro-uterine ligaments. It may be acute or chronic. The former may arise from a tear in the cervix extending into the parametrium, spread from the interior of the uterus, or originate in the depth of bruised tissue. Gener- ally it is combined with peritonitis, lymphangitis, or phle- bitis. It is as a rule unilateral. It may be traumatic or septic. Both are caused by germs, but the former is due to simple saprophytes, the latter to pathogenic microbes. Either of them may be puerperal or non-puerperal. The traumatic spreads in the loose connective tissue lying between the denser membranes ; the septic does not respect any boundary. First, there is a stage of infiltration, which may end in resolution, induration, or suppuration. Of all pelvic inflammations, cellulitis is the one most prone to end in suppuration. The pus spreads, and the abscess may open in a way similar to that followed by an intraperitoneal 66 xMEDICAL RECORD. one ; but while the puerperal form has a tendency to break through the skin, the non-puerperal form usually opens into one of the hollow organs. Rupture into the peritoneal cavity is rare. Cellulitis may end in cicatricial retraction, causing uterine displacement. Indurated tissue is apt to suppurate after a long time. Physical signs: The patient may have a chill, there is a rise in temperature; the pulse is accelerated ; she has pain in the lower part of the abdomen, and perhaps vesical and rectal tenesmus; she has no appetite; and her tongue is furred. But the pain does not come on so suddenly as in peritonitis, and is not so severe. There is less tendency to vomiting, and no meteorismus. By vaginal examination we find the vagina hot, swollen, and tender. If the seat of inflammation is in the broad ligament, we find at the side of the uterus a tumor that is sensitive on pressure and crowds the uterus to the opposite side. If both ligaments are inflamed the uterus is lifted up. If the sacro-uterine ligaments are inflamed we feel one or, both folds at the top of Douglas' pouch swollen and sensitive. More rarely the swelling is situated behind or in front of the uterus. If the affec- tion extends into the iliac fossa the corresponding leg is drawn up. If the tissue suppurates the swelling becomes softer, but rarely distinctly fluctuating, and there is an in- crease in the fever." — (Garrigues' Gynecology.) 4. The most common causes of sterility in woman are: Gonorrhea, absence or errors in development of any part of the genital tract, malformations of genitals, fistulse, lacerations, obesity, alcoholism, pelvic inflammations, dyspareunia, inflammations of uterus, tubes, or ovaries, elongated cervix. The cause may not be in the woman, but in the man. 5. In pudendal hernia: There is a tumor which is soft, insensitive, and rounded ; and which is apt to disap- pear with a gurgling sound on pressure or if the patient is put in the knee chest position ; it is tympanitic on per- cussion, and may give an impulse on coughing. In puden- dal hematocele: There is generally a history of trauma, no impulse on coughing, no resonance on percussion, and it is not reducible. 6. By perineorrhaphy is meant the various operations that are performed for the repair of lacerations of the perineum in the female. 7. Chronic endocervicitis. Etiology: Bacteria, especial- ly gonococci; lacerations of the cervix, tumors^ polypi, and excessive coitus. Pathology. The inflammation may spread, causing endometritis, salpingitis, ovaritis and peri- tonitis ; the body of the uterus is very apt to become in- volved. The mucous membrane becomes congested, thick- 67 MEDICAL RECORD. ened, and everted, and the cervix appears hypertrophied ; the secretion is increased and is thick, ropy, viscid and profuse. The cervical epithelium becomes eroded and the glands become enlarged. 8. See Rose and Carless' "Surgery" (1907), page 1285. 9. In both cases the prognosis is bad, a fatal result being inevitable unless timely and thorough operation is per- formed. Cancer of the body of the uterus progresses much slower than cancer of the cervix, and therefore in the former the disease will last longer. In cancer of the cer- vix the only hope lies in an early diagnosis, followed by operation. Hysterectomy gives much better results in cancer of the body of the uterus than it does in cancer of the cervix ; the ratio of cures being about 60 per cent. : 5 per cent. So the prognosis may be said to be better in cancer of the body of the uterus. 10. A tampon is a small roll of absorbent cotton, about 2Y2 x 1 inches, and is inserted into the vagina either with or without some medicinal substance. Around the center of the tampon is a strong string, long enough to hang out from the vulva, and by which the tampon can be removed. The details of the mode of use will depend upon the con- dition for which the tampon is used. In any case the pa- tient's bowels should be empty, and as a rule she is placed in either the dorsal or knee-chest position. The tampons are removed after about 36 hours, and a douche is then taken. The purposes of a vaginal tampon are: For con- trolling hemorrhage, either vaginal or uterine; to exert pressure; to support the uterus; as a means of applying medication locally; and for depleting inflammatory condi- tions. 11. Chancre of vulva is the first lesion of syphilis, is due to infection, has a long period of incubation, is gen- erally single, is not as a rule painful, only occurs once in a patient, buboes are apt to follow. Herpes of vulva is a local neurosis, is due to irritation, has no incubation pe- riod, consists of multiple vesicles appearing in crops, tingles and itches, has no lymphatic involvement. 12. Muscles of perineum : Transversus perinei, sphincter vaginae, erector clitoridis, compressor urethrae (and levator ani). Functions of perineal body: It holds in position the lower end of the rectum, vagina, and urethra and enables them to perform the functions of defecation, coitus, parturition, and urination; it strengthens the pelvic floor. HYGIENE. 1. See French's "Practice of Medicine" (1907), page 267; or Osier's "Practice of Medicine" (1909), page 234. 68 MEDICAL RECORD. 2. See French's "Practice of Medicine" (1907), page 107; or Osier's "Practice of Medicine" (1909), page 96. 3. A septic tank is a specially constructed tank for the treatment of sewage ; in it the sewage as such is destroyed, and new substances are built up in its place. In Cameron's septic tank system "the sewage is first led into a tank from which air and light are excluded. Digestive changes take place in the sewage within this tank as the result of anaerobic bacterial action, which is favored by the dark- ness, the absence of air, and the perfect stillness at which the sewage is maintained. Under these circumstances much of the solid matter is rendered soluble and dis- solved." — (Notter and Firth's Hygiene.) 4. Hygienic precautions to be taken in treating a case of tuberculosis: "The patient's quarters should be free from dust and admit of his spending many hours daily in the open air in all weathers, properly sheltered, and, if very ill, lying wrapped in a hammock or reclining chair. His bedroom should be well aired at night, draughts being avoided. The room should be uncarpeted and free from hangings. It should be often cleaned and periodically dis- infected. All sputum should be collected in paper spit- cups, which should be burned daily. Smoking should be forbidden. Harm is done by any exercise which results in fatigue, and while fever exists it should not be at- tempted at all. Patients should be taught the necessity of practicing lung gymnastics and breathing only through the nose, which should be kept clear and free from oc- clusion by secretions, or an hypertrophied catarrhal mu- cosa. * * * The clothing should be woolen, but not too heavy, or sweating is increased; and a flannel night- gown and loosely knit leggings should be worn at night in cool weather. The skin should be cleansed daily with alcohol and water." — (Thompson's Practical Medicine.) 5. See French's "Practice of Medicine" (1907), page 474; or Osier's "Practice of Medicine" (1909), page 28. 6. The best means of fumigating by formaldehyde gas are: (1) By Trillat's apparatus, which "allows the solu- tion of formalin to flow in a fine stream through a copper coil heated to redness by a flame beneath, and the gas and vapor passing directly into the room. The apparatus may be operated outside of a room, and the amount of gas liberated depends directly upon the strength and quan- tity of the solution evaporated. (2) In Schering's method the solid paraform is heated in a receptacle over an alcohol lamp, and is especially valuable in disinfecting small rooms, closets, etc. (3) The cheapest and most common form develops the gas directly by the oxidation of methyl 69 MEDICAL RECORD alcohol, the vapors of the latter passing over or through tubes or coils of heated metal. — (Gould and Pyle.) To fumigate by chlorine: For 1,000 cubic feet of space pour two ounces of H 2 S0 4 and three ounces of water, previously mixed and cooled, upon eight ounces of Nad and two ounces of Mn0 2 . The fluids must be mixed slowly and with care, and the salts should be in an earthen vessel upon a bed of sand. The generating apparatus should be high because chlorine gas is heavy. To fumigate by sulphur dioxide: For each i,ooo cubic feet of space, three pounds of sulphur are burned, care being taken to prevent accidents. In all cases, all aper- tures and crevices of the room should be closed, all closets, drawers, or other receptacles opened; and after the fumi- gation the room should be well ventilated and thoroughly cleansed with a solution of corrosive sublimate. 7. Gonorrhea exerts an inhibitory influence upon the procreative capacity of both man and woman; in the man it may cause oligospermia, azoospermia, spermatozoa without power of movement, epididymitis, stricture, etc. ; in the woman it may cause vaginitis, endocervicitis, endo- metritis, salpingitis, ovaritis. Each of these may inter- fere with propagation. Syphilis may cause disease or death of the fetus. Hence both gonorrhea and syphilis tend to prevent the propagation of the human specie?. 8. See French's "Practice of Medicine" (1907), page 499; or Osier's "Practice of Medicine" (1909), page 45. 9. See French's "Practice of Medicine" (1907), page 311; or Osier's "Practice of Medicine" (1909), page 127. 10. Incubation period of: Plague, is about 2 to 7 days; Smallpox, about 12 days; Diphtheria, about 2 to 7 days; Scarlatina, about 1 to 8 days; Measles, about 7 to 14 days. 11. The object of traps is to prevent the passage of sewer air into houses. If there were no traps sewer air would enter the houses, and there would follow symp- toms such as : Vomiting, diarrhea, headache, prostration, pallor, languor, loss of appetite, and susceptibility or liabil- ity to certain infectious diseases would be increased. 12. Two types of water filter: 1. The first has a filtering medium of carbon (charcoal), or iron. Such filters strain off the grosser suspended impurities and make the water more palatable through aeration. The best, when new, slowly oxidize organic matter, lessen hardness, diminish nitrites and ammonia, and increase nitrates. They do not remove disease germs; but may, after a few days' use, increase the number of bacteria. 2. The second type provides bacteriologically pure water, but has no effect on the chemical constituents in solution ; its pores are so 70 MEDICAL RECORD. tine as to strain off all microorganisms. Of this class are the Pasteur-Chamberland filter of unglazed porcelain, and the Berkefeld filter of infusorial earth. STATE BOARD EXAMINATION QUESTIONS. Colorado State Board of Medical Examiners. anatomy. i. Describe the clavicle, naming the muscles and liga- ments attached to it. 2. Name the muscles attached to the tibia. 3. Describe the hip joint. 4. Give the boundaries and contents of the popliteal space. 5. Give the origin, insertion, and nerve supply of the following muscles: Sartorius, triceps (in arm), gastroc- nemius, pectoral muscles. 6. Give the relations of the heart to the chest wall, and name the valves of the heart. 7. Describe the brachial plexus. 8. Describe the diaphragm ; mention its attachments and openings and tell what they transmit. 9. Give the relations of the prostate gland. 10. Name the structures seen in a cross-section of the thigh at its middle. physiology. 1. Give a physical description of the blood, together with its functions. 2. Give (a) origin, function, number per c.m.m. of red blood corpuscles, (b) origin, classification, function, and number per c.m.m. white blood corpuscles. 3. Give the forces which cause the blood to circulate in its vessels. 4. Give a physical description of lymph, together with its functions. 5. Define respiration, its function, and tell how per- formed. 6. Name the digestive ferments, tell the origin and function of each. 7. Name the organs of elimination and tell the function of each. 8. Give the function of (a) the liver, (b) spleen, (c) thyroid gland. MEDICAL RECORD. 9. Give the distribution and functions of the first five cranial nerves. 10. Give a short description of the vasomotor nervous system, with its functions. CHEMISTRY. 1. What is the chemistry of Fehling's test for glyco- suria? 2. Give a test for chlorides in water. 3. Name the principal chemical constituents and their average percentage in the stomach three hours after a meal of mixed food. 4. What is the significance of nitrites in drinking water? 5. Name the principal chemical constituents, and their average percentage, of normal urine. 6. What chemical reaction takes place when solutions of ammonia and acetic acid are mixed? 7. What is the chemical composition of the various renal calculi ? 8. What is percentage of albumin in normal blood serum? 9. Name tests^ for albumin in urine other than nitric acid and the application of heat. 10. What is a base? an acid? an alkali? an acohol? an ether? TOXICOLOGY. 1. Define toxicology. 2. Give symptoms of an overdose of chloroform, and treatment. 3. Give post-mortem appearance in a case of death from chloroform. 4. Give symptoms of poisoning by oxalic acid, and treatment. 5. Post-mortem appearance in death from an overdose of oxalic acid. 6. Give symptoms of poisoning by acetate of lead, and treatment. 7. Post-mortem appearance in death from acetate of lead. 8. Give signs of death by drowning. 9. Give symptoms of one asphyxiated by vapor from burning charcoal. 10. Post-mortem appearance of one asphyxiated by charcoal vapors. 72 MEDICAL RECORD SYMPTOMATOLOGY. i. What is pseudoleukemia and what are its principal symptoms and prognosis? 2. Differentiate bronchopneumonia from acute lobar pneumonia and capillary bronchitis. 3. What is exophthalmic goiter? Give its principal symptoms. 4. Give the etiology, symptomatology, and prognosis of tabes dorsalis. 5. What conditions commonly cause icterus? 6. What are the general classes of diabetes and how is each diagnosed? 7. Define variola ; describe the stages of this disease. 8. Name the exanthematous diseases of children and give the symptoms and differential diagnosis of each. 9. Name the different forms of nephritis ; give the symptoms and differential diagnosis of each. 10. Discuss the diagnosis of the following case : The patient is a married woman, age 34, large and fat in person. She has had two children and three miscarriages, the last six weeks ago. Otherwise she says her health has always been good until within three or four months; has been in the habit of drinking beer freely, but has not been intemperate. For two weeks there has been pronounced jaundice, anorexia, and bilious vomiting soon after eating; dizziness, flatulence, occasional diarrhea, with pain at epigastrium ; slight edema of feet and ankles. These symptoms have been increasing. There has been no head- ache and no hemorrhages or chills. The tongue was clean, the pulse 80, temperature 97-8°. The heart and lungs were normal. The liver was much enlarged and smooth. The spleen was felt below the ribs. There was no ascites. The urine had a sp. gr. of 1017, was of a deep yellow color, and contained a trace of albumen and much bile; sediment normal. The blood was negative. PATHOLOGY. 1. Name the system diseases of the afferent or sensory nervous system. 2. How is malaria propagated? 3. Enumerate the causes of sudden death in children. 4. What is the pathology of diabetes? 5. Describe the bacillus of diphtheria. 6. What are the causes of fatty liver? 73 MEDICAL RECORD. ;. Describe the blood in leucemia. 8. Discuss the relationship between arterial disease and chronic nephritis. 9. What are the microscopic findings of simple chronic gastritis? 10. Define : Vaccine, opsonin, bacterin, agglutinin, lysin. OBSTETRICS. 1. Give the various diameters of the inlet and outlet of the pelvis. 2. Give a good description of the anatomy of the uterus. 3. What are the different stages of labor? Describe each. 4. Give the various diameters of the fetal head. 5. Describe the sutures, fontanelles, and protuberances of the fetal head. 6. What is the mechanism of delivery in the R. O. P. position? 7. What are the indications and contraindications for the use of the obstetric forceps? 8. Give the indications for the induction of premature labor and describe the best method. 9. What is post-partum hemorrhage? How prevented? 10. What is puerperal sepsis? Give treatment. surgery. 1. Give the symptoms and prognosis of fracture of the olecranon process of the ulna. 2. Give the causes of non-union of fractures. 3. Give the causes and symptoms of compression of the brain. 4. Describe the different forms of dislocation of the shoulder-joint, and state which is the most frequent. 5. Give the symptoms and diagnosis of tuberculosis of the knee-joint. 6. Give the symptoms and diagnosis of hydrocele. 7. Give symptoms and diagnosis of stone in the common duct. 8. Give some of the causes of vesical hemorrhage. 9. Describe acute osteomyelitis. 10. What are the early symptoms of carcinoma of the breast? 74 MEDICAL RECORD ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Colorado State Board of "Medical Examiners. ANATOMY. i. The clavicle forms the anterior part of the shouldei girdle; it articulates internally with the first part of the sternum, and externally with the acromion process of the scapula. It is broad and flattened at its outer end, and thick and rounded at the inner end. It consists of a double curve, the outer part is concave forward, the inner part convex forward. The bone has two surfaces, superior and inferior; and two borders, anterior and posterior. On the under surface are the conoid tubercle, a groove for the subclavius, a rough impression for the rhomboid ligament. Muscles attached to it are: Deltoid, trapezius, pectoralis major, subclavius, sternomastoid, and sternohyoid. Liga- ments attached to it are: Interclavicular, rhomboid, conoid, trapezoid, and capsular (of sternoclavicular and acromio- clavicular articulations ) . 2. Muscles attached to the tibia are : Semimembranosus, semitendinosus, biceps, gracilis, sartorius, tibialis anticus, extensor longus digitorum, tibialis posticus, soleus, poplit- eus, flexor longus digitorum, quadriceps extensor. 3. The hip- joint is an enarthrodial joint, formed by the head of the femur and the acetabulum. The articular sur- faces are covered with cartilage. Near the center of the head of the femur is attached the ligamentum teres. The ligaments are: (1) The capsular, which embraces the mar- gin of the acetabulum above, and the neck of the femur below. (2) The ileofemoral or Y ligament,, which passes obliquely across the front of the joint, and is attached above to the anterior inferior spine of the ileum, and below to the anterior intertrochanteric line. (3) The ligamentum teres. (4) The cotyloid ligament, which deepens the aceta- bulum, and bridges over the cotyloid notch, being there called (5) the transverse ligament. The joint has a very extensive synovial membrane. It is capable of the follow- ing movements: Flexion, extension, abduction, adduction, circumduction, and rotation. 4. The Popliteal Space is bounded: Above, and ex- ternally by the Biceps; above, and internally by the Semi- membranosus and Semitendinosus; below, and externally by the Plantaris and external head of the Gastrocnemius; below, and internally by the inner head of the Gastroc- nemius. Contents: Popliteal vessels with branches, external 75 MEDICAL RECORD. saphenous vein, external and internal popliteal nerves, small sciatic nerve, lymphatic glands, and loose areolar tissue. 5. Sartorius. Origin: Anterior superior spine of ilium, and part of notch below. Insertion: Inner side of tibia near tubercle. Nerve supply: Middle cutaneous, or branch from anterior crural. Triceps : The long, or middle, head arises from a de- pression on the axillary border of the scapula immediately below the glenoid cavity; the external head from the root of the great tuberosity on the posterior surface of the humerus, and the upper part of the musculospiral groove ; the internal head from the posterior surface of shaft of humerus, below musculospiral groove, and the internal and external muscular septa. It is inserted into the back part of the upper surface of the olecranon process of the ulna. Nerve supply: Musculospiral. Gastrocnemius : The inner head arises from a depres- sion on the upper and back part of the inner condyle of the femur and the adjacent part of the femur; the outer head from an impression on the external surface of the outer condyle ; and from the posterior surface of the femur im- mediately above the condyle. It unites with the tendon of the soleus to form the tendo Achillis, which is inserted into the lower part of the posterior surface of the os calcis. Nerve supply: Internal popliteal. Pectoralis major. Origin: Anterior surface of inner half of clavicle, anterior surface of sternum, from the cartilages of the second to sixth ribs, and from the aponeu- rosis of the external oblique of the abdomen. Insertion: Into the outer bicipital ridge of the humerus. Nerve sup- ply: External and internal anterior thoracic. Pectoralis minor. Origin: From third and fourth and fifth ribs, just external to the cartilages, and from aponeu- rosis over intercostal muscles. Insertion: Into coracoid process of scapula. Nerve supply: Internal anterior thoracic. 6. A line from the lower border of the second left costal cartilage (one inch from sternum) to upper border of third right costal cartilage represents the base line; the right side will be a line drawn from right side of upper limit to seventh right chondrosternal articulation; the lower limit is a line from this last point to the apex (in fifth intercostal space, three and one-half inches from mid- line) ; the left side, from left end of upper border to left of apex. The valves are : Aortic, mitral, tricuspid, pul- monary (and Eustachian and coronary). 7. The brachial plexus is formed by the union and subse- quent division of the anterior divisions of the fifth, sixth, seventh, and eighth cervical and the first dorsal nerves. The union of the fifth and sixth makes the upper trunk; 76 MEDICAL RECORD. the seventh forms the middle trunk, and the eighth cervical and first dorsal make the lower trunk. Each of these trunks is divided into an anterior and a posterior branch. The anterior branches, from the upper and middle trunks, make the upper or outer cord of the plexus; the anterior branch of the lower trunk becomes the lower or inner cord; the three posterior branches unite to form the posterior or middle cord. The plexus lies between the Scalenus anticus and medius. The branches are: (r) Above the clavicle; communicating, muscular, posterior thoracic, and supra- scapular. (2) From outer cord: External anterior thoracic, musculocutaneous, and outer head of median. (3) From inner cord: Internal anterior thoracic, lesser internal cuta- neous, ulnar, and inner head of median. (4) From pos- terior cord: Subscapular, circumflex, and musculospiral. 8. The diaphragm is a musculofibrous septum which di- vides the thoracic from the abdominal cavity; it is fan- shaped; the broad, eliptical portion is horizontal, and the crura are vertical. It is attached to the ensiform, to the internal surfaces of the lower six costal cartilages, to bodies and intervertebral substances of first, second, and third lumbar vertebrae. Its openings are: (1) The aortic, transmitting the aorta, vena azygos major, and the thoracic duct; (2) the esophageal, transmitting the esophagus, pneumogastric nerves, and some small esophageal arteries ; (3) the opening for the vena cava, transmitting the inferior vena cava, and small branches of the right phrenic nerve ; (4) the right crural, transmitting the right splanchnic nerves; (5) the left crural, transmitting the left splanchnic nerves and the vena azygos minor. 9. Relations of prostate. Anteriorly: Symphysis pubis, anterior ligaments of bladder, branches of dorsal vein of penis. Posteriorly: Rectum. Laterally: Levator ani. Base: Surrounds neck of bladder, seminal vesicles, and vasa deferentia. The apex rests on triangular ligament. 10. At middle of thigh would be cut: Skin; fascia; muscles, adductor longus, sartorius, gracilis, rectus femoris, adductor brevis, adductor magnus, semimembranosus, semi- tendinosus, vastus internus, crureus, vastus externus, biceps ; vessels : profunda, femoral, external circumflex, internal saphenous vein ; nerves : external cutaneous, super- ficial obturator, anterior crural, sciatic, small sciatic ; bone : femur. PHYSIOLOGY. i. Physical properties of blood: Fluid, somewhat viscid, red, specific gravity from 1055 to 1062, alkaline reaction, saltish taste, characteristic odor, variable temperature (average about ioo° F.). Functions: For red and white corpuscles, see Question 2. 77 MEDICAL RECORD. Plasm conveys nutriment to the tissue; it holds in solu- tion the carbon dioxide and water which it receives from the tissues, and takes them to be eliminated by the lungs, kidneys, and skin ; it also holds in solution urea and other nitrogenous substances that are taken to and excreted by the liver or kidneys. 2. (a) Red Corpuscles. Origin: From red marrow of bones (and during fetal life from spleen, liver, and con- nective tissue cells). Function: To carry oxygen from the lungs to the tissues. Number: About 4,500,000 to 5,000,000 per cubic millimeter,. (b) White Corpuscles. Origin: From spleen, lymphatic glands, and lymphoid tissue. Classification: (1) Small mononuclears; (2) large mononuclears ; (3) transitionals ; (4) polynuclears; (5) eosinophils; and (6) mast cells. Function: (1) To serve as a protection to the body from the incursions of pathogenic microorganisms; (2) they take some part in the process of the coagulation of the blood; (3) they aid in the absorption of fats and peptones from the intestine, and (4) they help to maintain the proper proteid content of the blood plasma. Number: Normally between 7,000 and 10,000 or 12,000 in each cubic millimeter of blood. 3. The forces concerned in the circulation of the blood are : The force and frequency of the contractions of the heart, the elasticity and tone of the arterial walls, the resistance in the capillaries and tissues, the valves in the veins, the contraction of the muscles, the aspiration of the thorax. 4. Lymph is a colorless, albuminous fluid, alkaline in reaction, specific gravity of about 1015. Function: (1) It conveys nutriment to all cells not directly reached by the blood ; (2) in the intestines, it absorbs nutrient material (chiefly fat) and pours it into the blood stream for distri- bution; (3) it takes certain waste matters to the blood to be later eliminated by the lungs, kidneys, and skin. 5. Respiration is the act by which air is taken into and expelled from the lungs. Function: (1) To introduce oxygen into the system; (2) to excrete carbon dioxide. It is performed by inspiration and expiration. 6. DIGESTIVE FERMENTS ORIGIN Ptyalin. Pepsin Saliva. Gastric juice. FUNCTION Changes starches into dextrin and sugar. Changes proteids into proteoses and peptones in an acid medium. 7S MEDICAL RECORD DIGESTIVE FERMENTS ORIGIN FUNCTION Trypsin, Changes proteids into proteoses and peptones, and afterward decom- •- Pancreatic juice. poses them into leucin and tyrosin ; in an alka- line medium. Amylopsin. Steapsin. Converts starches into maltose. Emulsifies and saponifies fats. Invertin. Intestinal juice. Converts maltose into glucose. 7. The organs of elimination are: (1) Skin, for sweat (urea, water, salts) ; (2) lungs (for carbon dioxide, water) ; (3) kidneys, for urine (water, urea, salts), and (4) intestines (feces). 8. (a) The functions of the liver are: (1) The secretion of bile; (2) the formation of glycogen; (3) the formation of urea and uric acid; (4) the manufacture of heat, and (5) the conversion of poisonous and harmful into inert material. (b)The function of the spleen: The following theories have been held: (1) It is a source of production of the white blood corpuscles; (2) it is a source of production of the red blood corpuscles during fetal life; (3) it is a place where the red blood corpuscles are destroyed; (4) uric acid is produced in the spleen; (5) an enzyme is produced in the spleen and is carried by the blood to the pancreas, where it converts the trypsinogen into trypsin. (c) The function of the thyroid is not definitely settled; (1) it has some trophic function, regulating oxidation in the body, and it is supposed to have also a special influence on the vasomotor nerves, the skin, the bones, and on the sexual functions; (2) it is supposed to antagonize toxic substances, and (3) it produces an internal secretion. 9. I. Olfactory. Distributed to the Schneiderian mem- brane of nose. Function, sense of smell. - II. Optic. Distributed to retina. Function, sense of sight. III. Motor oculi. Distributed to: Superior rectus, in- ferior rectus, internal rectus, inferior oblique, and levator palDebrarum muscles. Function, motor to these muscles. IV. Trochlear. Distributed to superior oblique muscle. Function, motor to this muscle. V. Trifacial. First, or ophthalmic branch, supplies sen- sation to conjunctiva and skin of upper eyelid, cornea, skin 79 MEDICAL RECORD. of forehead and nose, lachrymal gland, and skin of nose. Second, or superior maxillary branch, supplies sensation to skin and conjunctiva of lower eyelid, nose, cheek, upper lip, upper teeth,, and palate. Third, or inferior maxillary branch, supplies sensation to external auditory meatus, side of head, mucous membrane of mouth, anterior two-thirds of tongue, lower teeth, and skin of lower part of face. This branch, in addition, supplies motion to the muscles of mastication (Masseter, temporal, external, and internal pterygoids), and the mylohyoid and anterior belly of the digastric. 10. The vasomotor nervous system consists of a center in the medulla, subsidiary centers in the spinal cord and vaso- motor nerves. The nerves are: (i) Vasodilator (which increase the caliber of the arterioles), and (2) vasocon- strictors (which diminish the caliber of the arterioles). Functions: (1) To dilate arterioles; (2) to constrict arterioles; (3) to maintain tonicity of blood vessels; (4) to maintain peripheral resistance; (5) to regulate the amount of blood supplied to a part. CHEMISTRY. 1. The glucose in the urine reduces the cupric sulphate of Fehling's solution to copper oxide. 2. Add a small amount of solution of nitrate of silver; in the presence of chlorides there will be a white precipi- tate insoluble in dilute HN0 3 , but soluble in dilute NH 8 . 3. Hydrochloric acid, pepsin, proteoses, peptones, etc. The relative and absolute amounts will necessarily vary according to the kind and quantity of food ingested. 4. Nitrites in drinking water denote contamination by sewage. 5. Normal urine consists of : Water, 95 per cent. ; solids, 5 per cent. The latter are : Urea, 2.8 per cent. ; uric acid, 0.06 per cent. ; hippuric acid, 0.03 per cent. ; creatinin, 0.06 per cent. ; extractives, 0.8 per cent. ; sodium chloride, 0.8 per cent.; phosphates, 0.2 per cent; sulphates, 0.1 per cent.; oxides of calcium, magnesium, sodium, and potassium, 0.1 per cent. 6. Ammonium acetate is formed. 7. Calculi are composed of: (1) Most frequently, uric acid, sodium or ammonium urate, calcium oxalate, calcium phosphate, and ammonio-magnesium phosphate. (2) More rarely, cystin, xanthin, potassium or magnesium or calcium urate, and calcium carbonate. 8. About 8 per cent. 9. Trichloracetic acid, salicyl-sulphonic acid, picric acid, potassium ferrocyanide, Spiegler's test, Tanret's test, Jolle's reagent. 80 MEDICAL RECORD. io. A base is a ternary compound capable of entering into double decomposition with an acid and producing a salt and water. An acid is a compound of an electro-negative element or radicle with hydrogen, part or all of which hydrogen it can part with in exchange for an electro-positive element with- out the formation of a base. An alkali is a substance which is basic in character, alka- line in reaction, is caustic in action, and can saponify fats. An alcohol is the hydroxide of a hydrocarbon radicle. An ether is the oxide of a hydrocarbon radicle. TOXICOLOGY. i. Toxicology is that branch of medical science which appertains to poisons; it includes their character, origin, actions, symptoms produced, antidotes, treatment, and de- tection. 2. Overdose of chloroform. Symptoms: I. Flushed face, contracted pupils, rapid and full pulse. II. Slow respira- tion, lowered temperature, dilated pupils, relaxed muscles, slow and full pulse. III. Irregular pulse, superficial respi- ration, dilated pupils, blue skin and lips, stertorous breath- ing, skin cool and covered with perspiration. Treatment : If the chloroform has been swallowed : Wash out the stomach, keep the patient warm, give hypodermic of strych- nine. If during inhalation, stop further administration, start artificial respiration, give oxygen, and faradic current. 3. Post-mortem appearances: Cerebral and meningeal vessels are engorged ; the lungs, liver, and kidneys are con- gested; the blood is dark and fluid; if the chloroform has been swallowed, the mucous membrane of mouth, stomach, and intestines is inflamed. The odor of chloroform may be present. 4. Symptoms of poisoning by oxalic acid: "The sour taste of the acid is rapidly followed by a burning pain, increasing in intensity, in the mouth, throat, and stomach, and persistent vomiting of a dark, 'coffee-ground' material. The pulse becomes small and imperceptible, and the patient dies in collapse, preceded frequently by convulsions, within half an hour. If the case be prolonged, swallowing becomes very difficult and painful ; there are numbness and tingling of the skin; twitchings of the facial muscles; convulsions, frequently tetanic ; delirium, and lumbar pain. Death occurs in some cases within three to ten minutes, sometimes almost immediately, and in some cases it is delayed for several days." Treatment: "Magnesia (magnesia usta) or slaked lime suspended in a small quantity of water, or mucilaginous liquid, should be given as soon as possible. If vomiting do not occur, and if the symptoms of corrosion be not marked, 81 MEDICAL RECORD. an emetic. The stomach pump should not be used, nor should the alkaline carbonates be depended upon as anti- dotes." 5. Post-mortem appearances: The mucous membrane of mouth, esophagus, and stomach is whitish, easily detached, and looks as if it had been scalded; the muscular coat is red and thick; the stomach contains a pultaceous material, acid, and like "coffee-ground" vomitus; the kidneys may show crystals of calcium oxalate; the urine may contain oxalates. 6. The symptoms of acute lead poisoning are : "Metallic taste; dryness of the throat; thirst; severe colicky abdom- inal pains, referred particularly to the umbilical region, and relieved by pressure ; pulse very feeble and slow ; great prostration; constipation; urine scanty and red; violent cramps ; paralysis of the lower extremities ; convulsions, and tetanic spasms." The treatment consists in administering "magnesium sulphate, which brings about the formation of the insoluble lead sulphate, while the purgative action of the magnesia is also useful. It should be preceded by an emetic, or by the use of the stomach tube." 7. Post-mortem appearances: Not always characteristic; mucous membrane of stomach may be red or gray; there is a blue line on the gums ; the colon may be constricted. 8. Signs of death by drowning: Froth at nostrils and mouth; pallor and goose-skin; maceration of epidermis of palms of hands and soles of feet; sand or mud may be under the nails or in the hands ; water and foreign matter are generally in the stomach and also in bronchi ; lungs are swollen and emphysematous; the right side of the heart is engorged and the left side is empty; the liver is engorged. 9. Symptoms of asphyxiation by charcoal vapor: Head- ache, drowsiness, vertigo, tinnitus aurium, vomiting, dysp- nea, pain and oppression in chest, irregular heart, stertorous breathing. 10. Post-mortem appearances: The blood is of a bright red color and the skin shows bright reddish spots on face, chest, and abdomen ; the brain is congested ; all the internal organs are colored by the bright red blood. SYMPTOMATOLOGY. i. Pseudoleukemia is a disease characterized by hyper- plasia of the lymphatic glands and progressive anemia; there is no great excess of white corpuscles. It is also known as Hodgkin's disease. Symptoms: Glands of neck, axilla, and groin are enlarged ; anemia is present ; the swellings are painless and do not, as a rule, suppurate; dyspnea may ensue; spleen and thyroid are apt to become enlarged; palpitation, shortness of breath, and hemic mur- 82 MEDICAL RECORD murs may be found. Prognosis is unfavorable; recovery is rare; cases may last from six months to three or four years. 2. Bronchopneumonia and capillary bronchitis are the same. LOBAR PNEUMONIA Generally a primary disease. Age has little influence. Sudden onset. Fever is high and regular. Ends by crisis between sixth and tenth day. Generally only one lung af- fected. The physical signs are dis- tinct, and there is a large area of consolidation. Sputum is rusty. BRONCHOPNEUMONIA Generally secondary (to bronchitis or an infectious disease). Generally found in very young or very old. Gradual onset. Fever is not so high, and is irregular. Ends by lysis, at no partic- ular date. Generally both lungs af- fected. Physical signs indistinct, and the evidences of con- solidation are indefinite. Sputum is rather streaked with blood. 3. Exophthalmic goiter is a disease characterized by: Exophthalmos, enlarged thyroid, tachycardia, and tremors. The principal symptoms are the four just mentioned, with sometimes anemia, fever, emaciation, diarrhea, pigmenta- tion, and profuse perspiration. 4. Tabes dorsalis. Etiology: Tabes dorsalis is a disease of adult life; is more common in men than in women; is more common in cities than in the country; syphilis is believed to be the most frequent direct cause; alcoholism, injury, exposure to cold and wet, have all been urged as causes, but they are not now assigned so important a place as etiological factors as was formerly the case. Symptoms: Loss of coordination; characteristic and unsteady gait; tendency to stagger when standing up with feet together and eyes closed ; sharp and paroxysmal pain, called crises; girdle sensation ; loss of knee-jerk and other reflexes ; Argyll-Robertson pupil. Prognosis: The disease is probably never cured; it may be arrested, and some of the symptoms may be ameliorated. It may last from four to twenty years. 5. Icterus may be caused by: Catarrh of the duodenum and common bile duct, pancreatic disease, gallstones, cir- rhosis of the liver, obstruction of the bile ducts, septicemia, 83 MEDICAL RECORD. acute yellow atrophy of the liver, tumors of liver, pancreas, stomach, or kidney, certain infections and poisons. 6. Diabetes mellitus and diabetes insipidus. In diabetes mellitus the urine has a high specific gravity and contains glucose ; complications are many and frequent. In diabetes insipidus the urine has a low specific gravity and does not contain glucose ; complications are rare. 7. Variola is an acute infectious and contagious disease, of unknown origin, and characterized by rapid onset and fever, pains in head and back, and a rash which appears on the third or fourth day and passes through the stages of macule, papule, vesicle, and pustule. For description of the stages of the disease, see French's "Practice of Medicine" (1907), pages 301 et seq., or Osier's "Practice of Medicine" (1909), pages 115 et seq. 8. The exanthematous diseases of children are: Variola, varicella, scarlet fever, measles, and German measles. Variola: The eruption usually appears first on the fore- head and wrists, and on the third or four day; it is first macular, then papular, then vesicular, and, finally, pustu- lar; it does not appear in successive crops; the spots are multilocular, and do not collapse on being punctured; the papule is hard and shotty, and does not disappear on stretching the skin. Varicella: The eruption usually ap- pears first on the trunk, is evident on the first day, comes in successive crops, is not shotty, and disappears on stretch- ing the skin ; the spots are unilocular, and collapse on being punctured. Scarlet fever: Period of incubation, from a few hours to seven days. Stage of invasion, twenty-four hours. Character of eruption, a scarlet punctate rash, beginning on neck and chest, then covering face and body; deesquamation is scaly or in flakes. The eruption is brighter, is on a red background, punctiform, and is more uniform; the temperature is higher, the pulse quicker; the tongue is of the "strawberry" type; the lymphatics in the neck may be swollen, and there is sore throat; Koplik's spots are absent. Measles: Period of incubation, ten to twelve days. Stage of invasion, four days. Character of eruption, small, dark red papules with crescentic borders, beginning on face and rapidly spreading over the entire body ; desquamation is branny. The eruption is darker, less uniform, more shotty; the temperature is lower, pulse slower, the tongue is not of the "strawberry" type ; coryza, coughing, and sneezing may be present; Koplik's spots are present. German measles: Period of incubation, ten to seventeen days. Stage of invasion, one day. Eruption ap- pears on first day, is most intense on second day, consists of red papules, often fades from face before it is seen on the limbs. The pulse is not much accelerated, all the symp- toms are slight. Desquamation is very slight. There may 84 MEDICAL RECORD. be slight sore throat and swollen cervical glands. Koplik's spots are absent. 9. The different forms of nephritis are: (1) Acute parenchymatous; (2) chronic parenchymatous ; (3) chronic interstitial. The following table is from Gould & Pyle's Cyclopedia : ACUTE PAREN- CHYMATOUS NEPHRITIS 1. Most common in children, from exposure or infec- tious fevers. 2. Edema of lower eyelids ; then of upper extremi- ties, trunk, and, lastly, lower ex- tremities. 3. Urine scanty, dark or smoky color, high specific gravity, 1025 or over. 4. Large amount of albumin. 5. Variety of casts, such as hya- line, blood, epithe- lial, and waxy casts, also free red blood globules, and epithelial cells. 6. Urea dimin- ished. 7. R e c o v e ries frequent. CHRONIC PAREN- CHYMATOUS NEPHRITIS i. Later life; often the conse- quence of acute at- tack. 2. In early stage same as acute form; later, drop- sy may diminish. 3. Urine normal or increased amount; specific gravity may fall to 1010; urine pale. 4. Late in at- tack, greatly di- minished ; occa- sionally absent. 5. Large and small granular casts ; compound granule cells, and fatty epithelium. 6. Urea dimin- ished. 7. R e c o v e ries rare. CHRONIC INTER- STITIAL NEPHRITIS i. Late life; of- ten results from alcoholism, gout, lead poisoning. 2. Dropsy slight or entirely absent. 3. Urine greatly increased ; specific gravity low, 1005; urine pale in color. 4. Albumin greatly diminished, often absent. 5. Hyaline or finely granular casts, occasionally dark in color; in- frequently blood casts and oil drop- lets. 6. Urea dimin- ished. 7. Indefinite du- ration, but never cured. 10. ''Gallstone in the common duct is possible, but un- likely, owing to the presence of splenic tumor, the lack of any intermission in the symptoms, and the absence of pain, fever, or chills. Catarrhal jaundice cannot be excluded, though it rarely leads to much enlargement of the liver or spleen. The points against cancer are the absence of pain, cachexia, or irregularities on the liver surface. Syphilis might produce all these symptoms, and can be positively 85 MEDICAL RECORD. excluded only by the therapeutic test. Cirrhosis, or the combination of cirrhosis and fatty infiltration, is the most likely diagnosis. This accounts better than any other hypothesis for the splenic enlargement, the large, smooth liver, and the jaundice. The gastric symptoms would then result from passive congestion of the stomach. The course of the case confirmed the diagnosis of cirrhosis.'* — (Cabot's Case Teaching in Medicine, from which the question is taken.) PATHOLOGY. i. Locomotor ataxia; general paralysis of the insane; herpes zoster. 2. Malaria is propagated by the bite of a mosquito (ano- pheles), which harbors the plasmodium malarise. 3. Causes of sudden death in children: Asphyxia, mal- formations, status lymphaticus, atelectasis, marasmus, in- ternal hemorrrhages, convulsions, and heart failure after diphtheria. 4. For pathology of diabetes, see French's "Practice of Medicine" (1907), pages 935 et seq.; or Osier's "Practice of Medicine" (1909), pages 412 et seq. 5. The characteristics of the bacillus of diphtheria: The bacilli are from 2 to 6 mikrons in length and from 0.2 to 1.0 mikron in breadth; are slightly curved, and often have clubbed and rounded ends; occur either singly or in pairs, or in irregular groups, but do not form chains; they have no flagella, are non-motile, and aerobic; they are noted for their pleomorphism; they do not stain uniformly, but stain well by Gram's method and very beautifully with Loefiler's alkaline-methylene blue. 6. The causes of fatty liver are : Anemia, phthisis, ca- chetic conditions, obesity, phosphorus poisoning, pulmonary diseases, infectious diseases (as yellow fever, pyemia). 7. In leukemia the blood is light in color, specific gravity is lowered, coagulation is slow, the white corpuscles are much increased in number (there may be from 150,000 to 500,000 per c. mm., or even more) ; myelocytes are present in large numbers in the splenomedullary type; red cells may be moderately diminished, and some may be nucleated. 8. Chronic nephritis is often secondary to anterioscle- rosis ; in other cases the arteries are sclerotic even if there is no causal relation between the two conditions ; sometimes it is hard to say which condition was primary. In many cases one or more of the coats of the arteries are thickened ; this thickening is not evenly distributed, and is apt to be most marked in the renal vessels. Aneurysm, atheroma- tous or hyaline changes are often present in the blood- vessels in nephritis. 9. In simple chronic gastritis, the cells of the glands are 86 MEDICAL RECORD. eroded, or atrophied, or show cloudy swelling; round cell infiltration is present in the tubules; the glands are dilated and filled with an exudate and desquamated cells ; new connective tissue forms between the glands. 10. Vaccine is an attenuated virus which, when intro- duced into the body of an animal, enables it to withstand the development of an infectious disease. Opsonin is that quality of a serum which makes a microorganism more susceptible to phagocytosis. Bacterin "is a preparation of killed bacteria suspended in normal solution which is injected for the purpose of raising the opsonic index of patients suffering from infection by that organism. Agglu- tinin is something in the blood serum of an animal affected with a bacterial disease which is capable of causing the clumping of the bacteria which caused the disease. Lysins are bacterial products which are capable of destroying alexins, and so promote the growth of the bacteria. OBSTETRICS. i. The pelvic diameters : Anterio-posterior. Oblique. Transverse. Inlet 4 inches. 4^2 inches. 5 inches. Outlet 5 inches. 4^ inches. 4 inches. 2. In the nulliparous adult the uterus is about three inches long, about two inches wide at the upper part, and about one inch thick. The uterus lies between the rectum behind and the bladder in front; it is below the abdominal cavity and above the vagina. Its position is one of slight anteflexion, with its long axis at right angles to the long axis of the vagina. The anterior surface of its body rests on the bladder, and the cervix points backward toward the coccyx. The uterus is not fixed, but moves freely within certain limits. It is held in place by ligaments — broad liga- ments, round ligaments, vesicouterine, and rectouterine. The arteries are the uterine and ovarian ; the nerves are from the uterovaginal plexus, the hypogastric plexus, and the vesical plexus. 3. Labor is divided into three stages : The first stage begins with the commencement of labor and ends with the complete dilatation of the os uteri. The second stage begins with the complete dilatation of the os uteri and ends with the birth of the child. The third stage immediately follows the second, and ends with the expulsion of the placenta and the beginning contraction of the uterus. For description of each, see Williams' "Obstetrics" (1909), pages 226 et seq.; or Hirst's "Obstetrics" (1909), pages 317 et seq. 4. The fetal head has the following diameters : Occipito- frontal, occipitomental, bitemporal, biparietal, suboccipito- bregmatic, trachelobregmatic, and mentobregmatic. Of 87 MEDICAL RECORD. these, the occipitofrontal is 4^2 inches, the occipitomental is 5J4 inches, and all the others are approximately ^A inches. 5. See Williams' "Obstetrics" (1909), page 152. 6. See Williams' "Obstetrics" (1909), pages 267 et seq.; or Hirst's "Obstetrics" (1909), page 404. 7. Indications for the use of forceps are: (1) Forces at fault: Inertia uteri in the presence of conditions likely to jeopardize the interests of mother or child, (a) Impending exhaustion; (b) arrest of head, from feeble pains. (2) Passages at fault: Moderate narrowing, 3% to 2> Z A inches, true conjugate; moderate obstruction in the soft parts. (3) Passenger at fault: A. Dystocia due to (a) occipito-poste- rior; (b) mentoanterior face; (c) breech arrested in cavity. B. Evidence of fetal exhaustion (pulse above 160 or below 100 per minute). (4) Accidental complications: Hemor- rhage ; prolapse funis ; eclampsia. All acute or chronic dis- eases or complications in which immediate delivery is required in the interest of mother or child, or both. Contraindications for the use of the forceps are: Me- chanical obstruction of any nature in the parturient canal ; incomplete dilatation of the os ; non-rupture of membranes ; non-engagement of the presenting part; the fact that the fetal head is either too large or too small ; distended blad- der or rectum. 8. Conditions that justify the induction of premature labor: (1) Certain pelvic deformities; (2) placenta prsevia; (3) pernicious anemia; (4) toxemia of pregnancy; (5) habitual death of a fetus toward the end of pregnancy; (6) the presence of a hydatidiform mole; (7) habitually large fetal head. The methods that may be employed are : Partial dilata- tion of the cervix and the introduction within the cervix (and vagina) of a tamponade of sterile gauze; (2) dilata- tion of the cervix; (3) puncturing the membranes; (4) introduction of a soft rubber bougie into the uterus; (5) intrauterine injection of glycerin, water, or some other fluid. For description of method, see Williams' "Obstet- rics" (1909), pages 381 et seq.; or Hirst's "Obstetrics" (1909), page 799- 9. Postpartum hemorrhage is hemorrhage from the par- turient canal occurring after the birth of the child ; it may occur immediately after the birth of the child, or at any time within several hours. Prevention: Exert gentle pressure on the fundus of the uterus during birth of fetus and secundines ; prevent too rapid delivery; after birth of head, give a dram of fluid extract of ergot; after complete delivery, give vaginal douche of creolin and water, and apply a uterine pad (ex- 88 MEDICAL RECORD. ternally) and abdominal binder; the patient should be kept quiet, both mentally and physically. io. Puerperal sepsis is a condition beginning within a week after labor, generally about the third or fourth day, and characterized by fever, inflammation of one ormore of the reproductive organs, and general septic infection. For treatment, see Williams' "Obstetrics" (1909), pages 883, et seq.; or Hirst's "Obstetrics" (1909), pages 732, 737, et seq. SURGERY. 1. Symptoms of fracture of the olecranon process of the ulna are: The upper fragment is drawn upward; swelling; the forearm is partly flexed and cannot be extended read- ily; flexion of elbow increases the distance between the fragments; crepitation is present. The prognosis is fair; fibrous union is common, and ankylosis, or joint stiffness may occur. 2. Causes of non-union of fractures: 111 health, want of approximation of the ends of the bone, want of blood supply in the bone, defective innervation of the bone, dis- ease of the bone, lack of rest, and immobility. 3. Causes of compression of brain: Hemorrhages, ab- scess, tumor, depressed fractures, edema, new growths of bone. Symptoms: Unconsciousness, slow and stertorous breathing, full and slow pulse, later becoming rapid, tem- perature raised, pupils unequal and fixed, hemiplegia, sphincters paralyzed, reflexes increased on paralyzed side. 4. The various dislocations of the shoulder-joint are: (1) Subcoracoid — forward, inward, and downward. (2) Subglenoid — downward, forward, and inward. (3) Sub- spinous — backward, inward, and downward. (4) Subclav- icular — forward, inward, and upward. The special diagnostic signs are : (1) Subcoracoid: The head of the humerus is felt below the outer end of the clavicle ; there is little or no shortening of the limb ; the elbow is directed outward and backward. (2) Subglenoid: The head of the humerus can be felt in the axilla ; the arm is decidedly lengthened ; the elbow is flexed, and there are signs of pressure on vessels and nerves. (3) Subspinous: The head of the humerus is felt below the acromion process and behind ; the arm is rotated in- ward and the elbow is displaced outward. (4) Subclavicular: The head of the humerus is felt below the clavicle ; the elbow is far from the side, and the limb may be shortened. The most frequent of these dislocations of the shoulder joint is the subcoracoid. 89 MEDICAL RECORD. 5. In tuberculosis of the knee-joint there are : Swelling at sides of and above patella; joint is semiflexed; skin is edematous; there is a doughy feel round patella; foot is everted ; muscles of thigh and calf are wasted ; pain is variable; tibia displaced outward and backward, is flexed and externally rotated; the limb shortened; abscesses may form. 6. Hydrocele is diagnosed by its translucency. Further, it is a tumor which grows from below upward, is tense and fluctuating, is generally situated in front of the testicle, and gives no impulse on coughing. 7. Stone in the common duct is characterized by: Jaun- dice, colic, clay-colored stools, collapse, nausea, vomiting; the liver is enlarged and tender, and the gall-bladder is shrunken. 8. Causes of vesical hemorrhage: Traumatism, stone, inflammation, tumors, tuberculosis, and filaria. 9. Acute osteomyelitis is inflammation of the bone and marrow; the term is often used now for inflammation of the bone. It is caused by infection, the bacteria gaining entrance either through a wound or by extension from neighboring tissues, or they may be brought by the blood. Pathological changes: "The area of the medulla affected becomes hyperemic; exudation occurs in the cancellous spaces, Haversian canals, and under the periosteum. Pus soon forms in these three situations. If the disease begins in the superficial part of the bone the pus may only be subperiosteal, the deeper part of the bone escaping, though large areas of the superficial portion may die from the combined action of (1) stripping up of the periosteum by the pus ; (2) strangulation of the vessels in the bone by the pressure of the exudation, and (3) the toxic action of the bacterial products. . . . When the disease begins in the deeper layers of the bone the pus may reach the periosteum, or extend along the medullary cavity, so that the veins become filled with septic thrombus, which may be disinte- grated and carried off as septic emboli (pyemia). There is profound toxemia, and necrosis of the whole diaphysis may occur. ... If the infection is mild, a chronic abscess may be formed in the cancellous tissue. The usual course of an acute case, if a patient survives, is that there is some necrosis of the shaft of the bone. The abscess bursts ex- ternally, and there are numerous openings in the skin lead- ing through openings (cloacae) in the periosteum and in- volucrum down to the sequestrum. The sequestrum be- comes loose in six weeks to six months. Symptoms: Sud- den onset; pain, tenderness, fever, chills, swelling of soft parts ; sometimes the joint can be moved gently ^without pain ; septicemia or pyemia may be present. It is to be diagnosed from three conditions: (1) Rheumatism, in 90 MEDICAL RECORD. which more than one joint is affected and the tenderness is in the joint, and not near it. (2) Tubular arthritis, in which the onset is slow and the trouble starts in the epiphy- sis rather than in the diaphysis. (3) Cellulitis, in which the bone and periosteum are not affected, and in which there is always a wound. 10. Early symptoms of carcinoma of breast: Hard no- dule, painless, fixed to gland, slowly but steadily increases in size; later it becomes harder and is fixed to skin; the skin is dimpled and may ulcerate ; the nipple may be re- tracted ; pain is present, and the breast cannot be freely moved. STATE BOARD EXAMINATION QUESTIONS. Connecticut State Medical Examining Board. anatomy. 1. Give (a) the number of bones in the human body; (b) classify them by regions of body; (c) classify by variety and give examples of each. Give briefly the macro- scopical and the microscopical structure of bone. 2. Describe the bony relationship and landmarks of the elbow joint. 3. Describe (a) the anatomical relations and the struc- ture of the mammary gland; (b) its nerve supply, and (c) its lymphatic drainage. 4. Of what does the sympathetic nervous system con- sist? What does the cerebrospinal system comprise? 5. State the origin and mention three branches of the ophthalmic nerve. To which system does this nerve belong, and what is its function? 6. Give the surface topography of (a) the appendix vermiformis; (b) the apex of the heart; (c) the apices of the lungs; (d) the two kidneys posteriorly. 7. What vessels unite to form (a) the basilar artery? O) What its course. 8. Define epigastric region and tell what organs or parts of organs are found in the same. Diagram. 9. What is (a) the stomach? (b) Give its gross anat- omy, (c) Give the minute anatomy of its mucosa. 10. Write briefly on (a) the decidual teeth; (b) the permanent teeth. PHYSIOLOGY. 1. What is the relation of the red and white corpuscles as to (a) size, (b) numbers, (c) function? What causes the variation in the color of the blood? 2. State the source and describe the function of the 9i MEDICAL RECORD. saliva. Explain the importance of thorough mastication as related to digestion. 3. Describe the muscular movements of the large intes- tine and explain their function. 4. Give a physiological explanation of the rapid respi- ration of pneumonitis. 5. Give the localization in the cerebral cortex of the motor function of (a) the left side of the face; (b) the right arm; (c) the left leg. Also illustrate the external cranial topography of the same. 6. Describe the .physical and nervous mechanism in normal urine evacuation. 7. How is the cornea nourished? 8. Define secretion and excretion. What organs of the body are purely excretory? 9. What part of the retina is most sensitive to visual impressions? Explain this. 10. Explain the condition causing muscle fatigue. CHEMISTRY AND HYGIENE. i. (a) How dangerous is impure air? (b) How tested? And what would be index of impurity? (c) What hygienic measures should be observed in our public schools? 2. Give chemical name and formula for the following: (a) blue vitriol; (b) common salt; (c) plaster of paris; (d) paris green; (e) sugar of lead; (/) corrosive subli- mate. 3. (a) What are peptones? (b) How evolved? (c) What are proteoses? (d) What are ptomaines? 4. (a) What is urea? (b) What is the pathological sig- nificance of urea in the urine? (r) How estimated? 5. (a) Given a neutral or faintly acid urine, and on heating it a precipitate forms. What is this precipitate, and how do you determine it? (b) Given an alkaline urine, and on heating no precipitate is seen; is albumen present? 6. (a) What are ferments? (b) Classify them, (c) Name three. 7. Name the chief constituents of the bile. 8. (a) Discuss the influence of alcohol on the race. Is it food or poison? 9. Is sanatorium treatment of tuberculosis worth while? 10. What are the symptoms of (a) acute poisoning of phosphorus? (b) Treatment and antidote, (c) Test. MATERIA MEDICA AND THERAPEUTICS. 1. What is the physiological action and therapeutics of phenacetin ? 2. What are the secondary effects of alcohol upon (a) 92 MEDICAL RECORD. stomach; (b) liver; (c) vasomotor system; (d) nervous system ? 3. What are emetics? In what way do they act? When indicated? When contraindicated? 4. What changes take place in the blood when illumi- nating gas is inhaled? Give treatment. 5. What is the action and dose of pilocarpine? Of apo- morphine? 6. What is the physiological action and what are the uses of potassium acetate? 7. Name three heart depressants and tell how they act. 8. How and upon what portion of the alimentary tract do the following drugs act: cascara, phosphate of soda, aloes, jalap and calomel? 9. Write a prescription in Latin, unabbreviated, for acute bronchitis, containing four ingredients, and give the action of each. 10. Treat a case of infantile convulsions. PRACTICE, PATHOLOGY AND DIAGNOSIS. 1. Describe the varieties of stomatitis : (a) simple, (b) aphthous, (c) mycotic, (d) ulcerative. Give the causes and treatment. 2. Give the etiology of congestion of the liver, active and passive. 3. Differentiate cardiac asthma from bronchial or spas- modic asthma — symptomatically and pathologically. 4. What are the causes of albuminuria, renal and extra- renal ? 5. Describe a case of acute inflammatory rheumatism; state its complications and sequels. 6. What are the varieties of influenza? Give the promi- nent symptoms of each variety. 7. Diagnosis of scarlet fever, smallpox, measles, and chickenpox; (a) period of incubation; (b) eruption; (c) course of each disease. 8. Differentiate between cerebrospinal fever and tuber- cular meningitis, pathologically. 9. Give the symptoms and treatment of chorea. 10. When is the eye ametropic, and what are the forms of ametropia? OBSTETRICS AND GYNECOLOGY. 1. (a) Describe the relation between ovulation and menstruation; (b) what is the present belief as regards migration of the ovum? 2. (a) State the cause of the premature detachment of the placenta; (b) what are the dangers? (c) Treatment. 3. (a) Give all the causes of prolonged first stage labor; (b) the dangers; (c) management. 93 MEDICAL RECORD. 4. (a) What are the indications for the use of forceps? (b) What condition necessitates version rather than for- ceps? (c) What cesarean section rather than version? 5. (a) What are the changes that occur in the uterus during pregnancy? (b) After delivery? 6. Differentiate an ovarian cyst from (a) ascites; (b) hydramnios; (c) fibroid tumor; (d) distended bladder; (e) hematometra. 7. (a) What is sapremia? (b) How does it differ from septicemia? (c) Should treatment differ? 8. (a) What pathological conditions require curettage? (b) Give the operative technique. 9. (a) Give three causes for post-partum hemorrhage. (b) Your treatment for each. 10. What are the operative procedures in the treatment of prolapsus uteri? Give indications for each. SURGERY. 1. Aneurysm: (a) causation; (b) varieties; (c) diag- nosis. 2. Carbuncle: (a) defined; (b) predisposing causes; (c) diagnosis; (d) treatment. 3. Local anesthesia. Technique of^ its application in hernis, removal of appendix, or thyroidectomy? 4. Practical demonstration of the use of Janeway's manometer. 5. State your views as to the scope and value of blood pressure determinations in operative surgery under gen- eral anesthesia. 6. Describe or depict the arrangement of the synovial sheaths of the palm and fingers. 7. Give the differential diagnosis between a fracture and dislocation at the hip. 8. Diagnosis and treatment of fractured clavicle. 9. What do you consider the best operation for internal hemorrhoids? Describe your technique. 10. Carcinoma: (a) varieties; (b) location in order of frequency; (c) metastasis; (d) differentiation? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Connecticut State Medical Examining Board. anatomy. 1. (a) There are 206 named bones in the human body. (b) By regions: The spine, with sacrum and coccyx; cranium, and face, with ossicles of the ear; hyoid, sternum, and ribs; upper extremities; and lower extremities. 94 MEDICAL RECORD (c) By variety: Long bones, as femur and humerus; short bones, as carpal and tarsal ; flat bones, as parietal and scapula ; irregular bones, as vertebrae and sphenoid. For structure, see Cunningham's "Anatomy" (1909), pages 71 and J2\ or, Gray's "Anatomy" (1908), pages 34 to 40. 2. There are three bony points : The external condyle of the humerus, the internal condyle of the humerus, and the olecranon process of the ulna. When the forearm is extended these three points are in a straight line; when the forearm is flexed, the olecranon is a little below the line joining the two condyles. The head of the radius can be felt from behind, nearly one inch below the external condyle. The internal condyle is more prominent than the external condyle ; the olecranon is nearer to the inner than to the outer condyle. 3. See Cunningham's "Anatomy" (1909), pages 1207 and 923; or, Gray's "Anatomy" (1908), pages 1516 and 810. 4. "The sympathetic nervous system consists of (1) a series of ganglia connected together by a great ganglionic cord, the gangliated cord, extending from the base of the skull to the coccyx, one gangliated cord on each side of the middle line of the body, partly in front and partly on each side of the vertebral column ; (2) of three great gangliated plexuses or aggregations of nerves and ganglia, situated in front of the spine in the thoracic, abdominal, and pelvic cavities respectively; (3) of smaller or terminal ganglia, situated in relation with the abdominal viscera ; and (4) of numerous fibers." The cerebrospinal system comprises the central nervous axis (brain and spinal cord) and the peripheral nerves (cranial and spinal). 5. The ophthalmic nerve is a branch of the trigeminal (fifth cranial) nerve. Its three branches are the Lacrymal, Frontal, and Nasal. It is a sensory nerve belonging to the cerebrospinal system. Its function is to supply sensation to the anterior half of the scalp, conjunctiva and skin of upper eyelid, cornea, skin of nose, mucous membrane of nose, and lacrymal gland. 6. See Gray's "Anatomy" (1908), (a) page 1331 ; (b) page 580; (c) page 1405; (d) page 1434. 7. (a) The two vertebral arteries, (b) It is situated in the center of a groove on the under surface or front of the pons, extending from the posterior to the anterior border. It lies between the sixth pair of cranial nerves. 8. See Cunningham's "Anatomy" (1909), pages 1046 and 1047; or, Gray's "Anatomy" (1908), pages 1243, 1244, and 1246. 9. See Cunningham's "Anatomy" (1909), pages 1050 to 1060; or, Gray's "Anatomy" (1908), pages 1277 to 1285. 95 MEDICAL RECORD. io. See Cunningham's "Anatomy" (1909), pages 1016 and 1022; or, Gray's "Anatomy" (1908), page 1206. PHYSIOLOGY. 1. (a) Red corpuscles are about 1/3200 of an inch in diameter; white corpuscles are about 1/2500 of an inch in diameter. (b) There are about 4,500,000 to 5,000,000 red corpuscles in each cubic millimeter of blood, and about 7,000 to 10,000 or 12,000 white corpuscles in each cubic millimeter of blood. (c) The function of the red corpuscles is to carry oxy- gen from the lungs to the tissues. Function of the white corpuscles: (1) To serve as a protection to the body from the incursions of pathogenic microorganisms; (2) they take some part in the process of the coagulation of the blood; (3) they aid in the absorption of fats and peptones from the intestine, and (4) they help to maintain the proper proteid content of the blood plasma. The variation in the color of the blood is due to the presence of oxygen in combination with hemoglobin, giving to arterial blood its red color, and the presence of carbon dioxide (with lessened oxygen), giving to venous blood its bluish color. 2. Source of saliva: The parotid, submaxillary, and sub- lingual glands (and the small mucous and serous glands of the mouth). The functions of the saliva are: (1) To moisten the mouth, (2) to assist in the solution of the soluble portions of the food, and thus (3) to administer to the sense of taste; (4) to lubricate the bolus of food, and thus (5) to facilitate the acts of mastication and deglutition, and (6) to change starches into dextrin and sugar. Thorough masti- cation prepares the solid and fibrous foods for the more ready and speedy action of the various digestive juices; it enables these foods to present also a larger surface to the action of these juices. Food that is imperfectly masticated may cause suffocation; it is also a well-known cause of indigestion. 3. The muscular movements of the large intestine are chiefly of the peristaltic or vermicular kind. This is a wave-like motion, characterized by a contraction of the circular fibers behind a bolus and a relaxation of the fibers in advance of it. The result is a movement forward of the bolus, and as it moves it is followed by a ring of constric- tion and preceded by a ring of relaxation or inhibition. Under the influence of this peristaltic movement the con- tents of the large intestine (food residues and excrementi- tious matter) are gradually carried downward toward the sigmoid flexure, where they accumulate prior to their ex- trusion from the body. The effects of the peristaltic waves are to some extent interfered with by antiperistaltic waves, 96 MEDICAL RECORD. which, beginning in the transverse colon, run toward and to the cecum. The intestinal contents are thereby driven back toward the cecum. The effect is a still further admixture with the secretions and exposure to the absorbing mucosa. There is some evidence also that the antiperistaltic wave may force some of the liquefied contents through the ileo- colic opening into the small intestine because of the relax- ation of the sphincter muscle. (From Brubaker's Physi- ology.) 4. The rapid respiration in pneumonia is due to: (1) Toxemia, which affects the respiratory center; (2) the amount of lung involved; (3) the limited air space left for use; (4) pain, 5. See Cunningham's "Anatomy" (1909), pages 1224 and 1227; or, Gray's "Anatomy" (1908), pages 966 and 970. 6. "The urine trickles drop by drop down the ureters, into the bladder, where it collects and gradually distends it. The exit from the bladder is opposed by the sphincter vesicae, or, as some believe, by the elastic and muscular fibers of the urethra. The urine is expelled by the con- traction of the walls of the bladder, more especially by the detrusor vesicae, and is assisted when much distended by the contraction of the abdominal walls. Micturition is a reflex act, but one which (with the exception of infants) is under the influence, if not under the control of the will. The mechanism appears to consist of an automatic center in the lumbar part of the cord, maintaining the constant contraction of the sphincter, a second center, which, when stimulated, excites contraction in the detrusor. These centers are antagonistic, so that an afferent impulse from the bladder excites the detrusor center, at the same time inhibiting the sphincter center. These centers are nor- mally under the control of the will, so that, although an afferent impulse may ascend from the bladder to the centers of the cord and up to the sensorium, yet by an effort of will the sphincter center may be assisted and the detrusor inhibited, or vice versa. Thus when the bladder becomes distended an afferent impulse from the bladder reaches both lumbar center and the brain; if the opportunity is favorable for micturition the controlling influence of the will is removed, the reflex contraction of the detrusor taking place, assisted, perhaps by the voluntary abdominal muscles." (Ashby's Physiology.) 7. The cornea is nourished chiefly by the lymph in the corneal spaces or lacunae and canaliculi. At its border, for a very short distance, there are also capillary loops from the sclera and conjunctiva. 8. Secretion is the process by which certain organs (glands and membranes) separate from the blood certain constituents which are further elaborated and serve some further office in the economy. 97 MEDICAL RECORD Excretion is a similar process by which there are re- moved from the blood waste materials, and products of no further use to the body, and which, if retained, would be injurious. The purely excretory organs are : Kidneys and skin. 9. The fovea centralis in the macula lutea is the part of the retina most sensitive to visual impressions. Here the end organs of the optic nerve are most highly developed; the cones are here increased both in number and in size. 10. Causes of fatigue in muscle: Presence of sarcolactic acid and acid potassium phosphate in the muscle; using up of the material from which the energy is obtained; and accumulation of carbon dioxide and other waste products. CHEMISTRY AND HYGIENE. i. (a) The danger of impure air depends upon: (1) The amount of oxygen present; (2) the amount and nature of impurities present (the chief being carbon diox- ide, organic matters, crowd poison, disease germs, com- bustion products, emanations from sewers or marshes, con- taminations from trade and manufacturing processes, and decomposition products). (b) Pettenkofer's method of determining the percentage of carbon dioxide in the air: A large cylindrical container of known capacity, say, 15 liters, is filled with the air to be examined; a known volume of barium hydroxide is then added and shaken up with the air. The carbon dioxide combines with the barium hydroxide to form a barium car- bonate, which is insoluble, and also incapable of acting upon an indicator. The barium hydroxide employed is of known strength, e.g. it may be of such strength that 1 c.c. of the solution neutralizes 1 c.c. of carbon dioxide at nor- mal temperature and pressure. If then we find that 10 c.c. of the barium hydroxide has been neutralized by the carbon dioxide present in the air, we know that 10 c.c. of carbon dioxide is present in 15 liters or 15,000 c.c. of the air examined. 2. CHEMICAL NAME. FORMULA (a) Blue vitriol. Cupric sulphate. CuS0 4 . (b) Common salt. Sodium chloride. NaCl. (c) Plaster of Paris. Calcium sulphate. CaS0 4 . (d) Paris green. Cupric aceto - met Cu(C 2 H 3 2 ) 2 + 3 arsenite. CuAs 2 4 . (e) S ug a r of lead. Lead acetate. Pb(C,H,O0* (f) Corrosive sublimate. Mercuric chloride. HgCl 2 . 98 MEDICAL RECORD 3. (a) Peptones are the final products of the action of proteolytic ferments on proteids. (b) By the action of proteolytic ferment (pepsin and trypsin) on proteids. (c) Proteoses are the intermediate products in the con- version of proteids into peptones. (d) Ptomaines are basic, nitrogenous compounds, pro- duced from protein material by the bacteria which cause putrefaction. 4. (a) Urea is the end product of the proteid metabol- ism of the body. It is a crystalline solid, soluble in water, colorless, odorless, with a slightly bitter taste ; it is neu- tral in reaction, but basic in character ; dilute aqueous solutions are not decomposed by boiling, but by prolonged boiling urea is hydrolized to ammonia and carbon dioxide ; urea forms compounds with acids and also with certain salts and oxides. Formula is CON 2 H 4 . (b) Urea is always present in the urine, a healthy man excreting about 500 grains of urea daily. Pathologically, the amount of urea excreted may be diminished or in- creased, as follows : A diminution may be due to some condition interfering with the normal transformation of proteins in the body, as in certain chronic diseases. More frequently, however, a diminished proportion of urea in the urine is not due to a diminution in the production, but to the fact that the urea formed has not been separated by the kidneys as in uremia, and in diseases attended with dropsical effusions. Pathologically it is increased in the early stages of all acute febrile diseases, except when these are attended by the formation of dropsical deposits or by diarrhea; during reabsorption of dropsical fluids; in both forms of dia- betes, and in chronic interstitial nephritis. (c) "The specific gravity of the urine is carefully de- termined, as well as that of the liquor sodae chlorinatse. One volume of the urine is then mixed with exactly seven volumes of the liquor sodse chlorinatse, and, after the first violence of the reaction has subsided, the mixture is shaken from time to time during an hour, when the decomposi- tion is complete ; the specific gravity of the mixture is then determined. As the reaction begins instantaneously when the urine and reagent are mixed, the specific gravity of the mixture must be calculated by adding together once the specific gravity of the urine and seven times the spe- cific gravity of the liquor sodae chlorinatae, and dividing the sum by eight. From the quotient so obtained the specific gravity of the mixture after decomposition is subtracted; every degree of loss in specific gravity indicates 0.7791 gram of urea in 100 c.c. of urine. The specific gravity de- terminations must all be made at the same temperature, 99 MEDICAL RECORD and that of the mixture only when the evolution of gas has ceased entirely." (Witthaus' Manual of Chemistry.) ^ 5. (a) Albumin or phosphates. Add HN0 3 ; this will dissolve the phosphates, but not the albumin. (b) Albumin may or may not be present. 6. Ferments are certain microorganisms (bacteria, mould and yeast fungi) which, by their growth, cause definite chemical changes in certain substances contained in the media in which they develop. They are classified as: (1) Proteolytic, e.g. trypsin; (2) amylolytic, e.g. ptyalin; (3) steatolytic, e.g. steapsin; (4) inverting, e.g. invertin; (5) coagulating, e.g. milk curdling ferment. 7. Water, sodium glycocholate, sodium taurocholate, bilirubin, biliverdin, fats, soaps, cholesterin, lecithin, urea, sodium chloride. 8. The influence of alcohol on the race cannot be dis- cussed in the space at our disposal. Most of what is written on the subject has absolutely no scientific value, being characterized by prejudices and diatribes rather than by logic and science. Probably most races would benefit if some of the individuals of these races consumed less alcohol. That alcohol is abused or misused is true; so are money and many other things, and the abuse of a thing is no argument against its legitimate use. As to whether alcohol is a food or a poison, there is also much difference of opinion. Taken in excess, it may be a poison ; but many scientists believe that it has also a food value. Much depends on the conditions under which it is used and the quantity in which it is taken. The student (and examiner) will easily find any quantity of "literature" which will favor his own particular views or prejudices in the matter, but very little of it is of scientific value. 9. See French's "Practice of Medicine" (1907), page 394; or, Osier's "Practice of Medicine" (1909), page 354. 10. (a) Eructation of gas having the odor of garlic. The mouth, when observed in the dark, is frequently faintly luminous (phosphorescent). After several hours, pain in the throat, a sense of heat in the epigastrium, nausea, and vomiting. The vomited matters are sometimes bloody, and frequently luminous when agitated in the dark. The abdomen is tender, and there are diarrhea and colicky pains. After one or two days these symptoms cease, there remaining only pain in the back and limbs and a feeble pulse. Death sometimes occurs suddenly in from two to four days. Usually about the fourth day the patient be- comes^ jaundiced, suffers from headache, insomnia, and retention of urine, rapidly becomes delirious and coma- tose, and dies. (b) The unabsorbed^ portion is to be removed as speedily as possible by an emetic of copper sulphate or apomorphin. 100 MEDICAL RECORD. No chemical antidote is known. French oil of turpentine (the older the better) should be given as a physiological antidote. The food should be free from oils and fats. (c) The matters supposed to contain phosphorus are rendered fluid by dilution with water and acidulated with sulphuric acid. They are placed in a flask upon a sand bath and the flask connected with a Liebig's condenser, which is placed in absolute darkness. Upon heating the flask any phosphorus present is volatilized, and, condensing in the tube, forms a luminous ring. This reaction is very delicate, and the appearance of the ring is proof positive of the presence of unoxidized phosphorus. (From Witt- haus' Essentials of Chemistry and Toxicology.) MATERIA MEDICA AND THERAPEUTICS. i. Phenacetin. Physiological Action: Lowers body temperature, and is an analgesic; it is also a cardiac de- pressant. Therapeutics: In fevers, as an antipyretic, and to relieve pain; also used in epilepsy. 2. The stomach is overstimulated and congested, the gas- tric glands are similarly affected, gastric catarrh ensues, digestion is impaired, and morning vomiting may occur. The liver and hepatic cells suffer in a similar way. De- generative changes may follow. It is a vasodilator, and lowers arterial tension. The nervous system is specially affected, and eventually paralysis or epilepsy may result from the long continued use of alcohol. 3. Emetics are agents which produce vomiting. They act: (1) By irritating the nerves of the stomach, esopha- gus, or pharynx; (2) through the circulation; (3) by irri- tation of the vomiting center in the medulla. Indications: To produce vomiting or nausea; in catarrhal conditions of the respiratory tract; to remove poisons or foreign bodies from stomach, esophagus, etc. ; to empty the stomach. Contraindications: Severe cardiac lesions and aortic aneurysm ; atheroma ; when the patient is so weak that there is danger of collapse; in poisoning by caustics; in hernia or peritonitis, or in cases of high arterial tension. 4. When illuminating gas is inhaled, the color of the blood is a very bright red, much brighter than normal ; the cells are not altered in appearance, but the red corpuscles are incapable of carrying oxygen to the tissues, as the carbon monoxide forms with the hemoglobin a compound which is very much more stable than oxyhemoglobin. The spectroscope shows, also, a characteristic absorption spec- trum. Treatment: Stimulants, fresh air, bleeding, and hypodermocleisis, or infusion of normal salt solution. 5. Pilocarpine: Dose, gr. 1/5. Action: Stimulant of secretory nerves and of involuntary muscles, myotic, nerv- ous depressant, sudorific. 101 MEDICAL RECORD. Apomorphine hydrochloride. Dose: As an emetic, gr. i/io subcutaneously ; as an expectorant, gr. 1/30. Physio- logical action: It acts on the vomiting center in the medulla, hence is emetic; it increases pulse, blood pressure, and rate of respiration; it is also an expectorant. 6. Potassium acetate. Physiological action: Antacid, increases alkalinity of the blood and of the urine, is a diuretic, and a diaphonetic. Uses: In rheumatism, gout, fevers, dropsy, nephritis, cystitis, and irritation of the urinary tract. 7. Three cardiac depressants: (1) Antimony, which de- presses the motor ganglia; (2) pilocarpine, which stimu- lates the inhibitory ganglia and depresses the heart muscle and also the motor ganglia; (3) hydrocyanic acid, which is a direct cardiac poison, depressing the heart muscle and the motor ganglia. , 8. Cascara is a stomachic and laxative, and acts on the stomach and small intestine. Phosphate of sodium is a saline, hepatic stimulant, and cholagogue; it acts on liver and colon. Aloes is a purgative, hepatic stimulant, and cholagogue, and acts on the large intestine (chiefly de- scending colon and rectum) and liver. Jalap is a drastic purgative, and acts on the small intestine. Calomel is a simple purgative, and acts on the small intestine. 9. 5- Ammonii carbonatis, 3j. Spiritus chloroformi, 3j. Syrupi pruni virginianse, Jj. Misturse glycyrrhizse composite, q.s. ad. Jviij. Miscc. Signa : One tablespoonful every three hours. The ammonium carbonate is a respiratory stimulant and a stimulating expectorant. The chloroform disguises the taste of the ammonium. The prunus virginiana is a sedative and expectorant. The glycyrrhiza is an expecto- rant. 10. See French's "Practice of Medicine" (1907), page 1 124; or Osier's "Practice of Medicine" (1909), page 1058. practice, pathology, and diagnosis. 1. See French's "Practice of Medicine" (1907), pages 707 to 710; or Osier's "Practice" (1909), pages 434 to 437. 2. See French's "Practice of Medicine" (1907), page 817; or Osier's "Practice of Medicine" (1909), page 541. 3. See French's "Practice of Medicine" (1907), page 659; and Osier's "Practice of Medicine" (1909), page 610. 4. Albuminuria is found: "(1) In fevers, as typhoid and pneumonia. (2) In valvular heart lesions, degeneration of the heart muscles, diseases of the coronary arteries, im- peded pulmonary circulation, in pregnancy by pressure upon the renal veins, in intestinal catarrh, and in Asiatic cholera. 102 MEDICAL RECORD. (3) In purpura, scurvy, leukemia, pernicious anemia, jaun- dice, diabetes, and syphilis. (4) After taking lead, mer- cury, iodine, phosphorus, arsenic, antimony, chloroform, cantharides, oxalic, carbolic, salicylic, or the mineral acids, turpentine and nitrates. (5) In large amounts in acute nephritis and chronic parenchymatous nephritis; in small amounts in chronic interstitial nephritis, and amyloid kid- ney." — (Witthaus' Essentials of Chemistry.) 5. See French's "Practice of Medicine" (1907), pages 222 to 230; or Osier's "Practice of Medicine" (1909), pages 219 to 226. 6. See French's "Practice of Medicine" (1907), pages 132 to 136; or Osier's "Practice of Medicine" (1909), pages 153 and 154. 7. Scarlet fever: Period of incubation, from a few hours to seven days. Stage of invasion, twenty-four hours. Character of eruption, a scarlet punctate rash, beginning on neck and chest, then covering face and body ; desqua- mation is scaly or in flakes. The eruption is brighter, is on a red background, punctiform, and is more uniform; the temperature is higher, the pulse quicker; the tongue is of the "strawberry" type, the lymphatics in the neck may be swollen, and there is sore throat; Koplik's spots are absent. Smallpox: The eruption usually appears first on the forehead and wrists, and on the third or fourth day; it is first mascular, then papular, then vesicular, and finally pustular ; it does not appear in successive crops ; the spots are multilocular, and do not collapse on being punctured; the papule is hard and shotty, and does not disappear on stretching the skin. Period of incubation is from eight to fourteen days. Measles: Period of incubation, ten to twelve days. Stage of invasion, four days. Character of eruption, small, dark red papules with crescentic borders, beginning on face and rapidly spreading over the entire body; desquamation is branny. The eruption is darker, less uniform, more shotty; the temperature is lower, pulse slower, the tongue is not of the "strawberry" type ; coryza, coughing, and sneezing may be present ; Koplik's spots are present. Chickenpox: The eruption usually appears first on the trunk, is evident on the first day, comes in suc- cessive crops, is not shotty, and disappears on stretching the skin ; the spots are unilocular, and collapse on being punctured. The period of incubation is from four to fourteen days. 8. See Osier's "Practice of Medicine" (1909), pages 159 and 301. 9. See French's "Practice of Medicine" (1907), pages 1 1 18 and 1 120; or Osier's "Practice of Medicine" (1909), pages 1048 and 1052. 10. The eye is ametropic when, in a condition of rest, 103 MEDICAL RECORD. parallel rays of light are focussed either behind or in front of the retina, and not on it. The forms of ametropia are: Hyperopia, myopia, and astigmatism. OBSTETRICS AND GYNECOLOGY. i. See Williams' "Obstetrics" (1909), pages 83 and 85; or Hirst's "Obstetrics" (1909), pages 65 and 62. 2. See Williams' "Obstetrics" (1909), pages 805, 808, and 810; or Hirst's "Obstetrics" (1909), pages 583 and 585. 3. See Williams' "Obstetrics" (1909), pages 658 to 663; or Hirst's "Obstetrics" (1909), pages 439 to 444. 4. (a) Indications for the use of forceps are : "1. Forces at fault: Inertia uteri in the presence of conditions likely to jeopardize the interests of mother or child, (a) Im- pending exhaustion; (b) arrest of head, from feeble pains. 2. Passages at fault: Moderate narrowing, 3% to zYa inches, true conjugate; moderate obstruction in the soft parts. 3. Passenger at fault: A. — Dystocia due to (a) oc- cipitoposterior, (b) mentoanterior face, (c) breech ar- rested in cavity. B. — Evidence of fetal exhaustion (pulse above 160 or below 100 per minute). 4. Accidental com- plications: Hemorrhage; prolapsus funis; eclampsia. All acute or chronic diseases or complications in which imme- diate delivery is required in the interest of mother or child, or both." (b) Indications for version are: (1) In trans- verse presentations: (2) in placenta prsevia; (3) in mal- presentations of the head; (4) in simple flattened pelvis, and in minor degrees of pelvic contraction; (5) in pro- lapsed funis; (6) in sudden death of the mother, and (7) in any case where speedy delivery is imperative, (c) Indi- cations for cesarean section are : Extreme pelvic contrac- tion or deformity in which delivery by forceps or version or symphyseotomy is impossible, and in which craniotomy is either impossible or would be more dangerous to the mother; the presence of extreme atresia of the vagina; rupture of the uterus ; sudden maternal death. 5. See Williams' "Obstetrics" (1909), pages 165 to 169, 185, and 332 to 334; or Hirst's "Obstetrics" (1909), pages 182 and 348 to 353- 6. ASCITES. OVARIAN CYST. I. Previous history of 1. No such history. visceral disease. 2. Enlargement compara- 2. Gradual. tively sudden. 3. Face puffy; color 3. Facies ovariana. Ane- waxy; early anemia. mia absent, or later. 104 MEDICAL RECORD ASCITES. OVARIAN CYST. 4. Patient on back, en- largement symmetrical; flat in front. 5. Sitting up, abdomen bulges below. 6. Navel prominent and thinned. 7. Fluctuation decidedly clear, diffuse throughout abdomen, but avoids highest parts in all positions, and al- ways has a hydrostatic level. 8. Intestines float on top of fluid; hence percussion gives clear tympanitic note over the highest parts of abdominal cavity, and dull- ness in lowest parts for all positions, i.e. areas of res- onance and dullness change with position. 9. Vaginal touch detects fluctuation, bulging into va- gina. 10. Uterus in prolapsed location, but position un- changed. Size and mobility unchanged. 11. Hydragogues and diu- retics temporarily remove the fluid. 12. Fluid light straw color and thin. Coagulates spon- taneously. 4. Asymmetrical until tu- mor is quite large; promi- nent in front. 5. No appreciable change. 6. Navel usually un- changed. 7. Less clear; limited to cyst ; not modified by change of position. No hydrostatic level. 8. No change in areas of dullness and resonance with change of position. Dull- ness over cyst. Clear reso- nant note in all parts beyond cyst limits, i.e. in flanks and toward the diaphragm. 9. Vaginal fluctuation less I clear or absent. 10. Uterus displaced for- | ward or backward, or later- j ally by pressure of cyst. 11. Medicines have no ef- fect. 12. Fluid light or dark I and of varying consistency; ! albuminous, but does not I coagulate spontaneously; may contain colloid matter. HYDRAMNIOS. 1. Evidence of pregnancy. 2. Rapid development. 3. Ballottement. 4. Distention symmetrical. 1. 2. 3- 4- side. OVARIAN CYST. Not usual. Less rapid. Absent. Distention more on one 105 MEDICAL RECORD. FIBROID TUMOR. i. Slow growth. 2. Facial expression un- changed. Face may be full and flushed ; later pale from hemorrhage. 3. General health usually- unimpaired except from loss of blood, if submucous or mural ; may be painful. 4. Abdomen usually very asymmetrical from irregu- lar shape of tumor. 5. Abdominal veins not usually enlarged. 6. Action of kidneys nor- mal. 7. Usual menorrhagia. 8. Elasticity, not fluctua- tion. No percussion wave. 9. Surface firm and usual- ly lobulated. 10. Vaginal touch and con- joined examination show tu- mor dense and firm, and, unless pedunculated, contin- uous with uterus. Uterus large and heavy. 11. Uterine cavity much elongated. 12. Uterus moves with tu- mor. OVARIAN CYST. 1. Usually more growth. 2. Facies ovariana. rapid 3. General health early impaired from emaciation. Not painful. 4. Abdomen more sym- metrical, especially when tu- mor is large. 5. Usually enlarged, espe- cially in large polycysts. 6. Kidneys less active. 7. Menstruation unchanged or diminished. 8. Fluctuation marked. Percussion wave marked. 9. Surface yielding; in monocysts, regular; in poly- cysts, irregular. 10. Uterus normal, except displacement from pressure. Tumor compressible, fluctu- ating, detached from uterus. 11. Not materially elon- gated. (This is a most im- portant diagnostic point.) 12. Does not move with tumor. Distended bladder: The use of a catheter will absolutely settle the diagnosis. Hematometra: The enlargement is perfectly symmet- rical, and external os or cervix will be found completely closed. — (Tables from Dudley's Gynecology.) 7. See Williams' "Obstetrics" (1909), pages 852 and 856; or Hirst's "Obstetrics" (1909), page 764. 8. Curettage. Pathological Indications: To remove pieces of retained placenta or decidua, endometritis, mucous polypi, hemorrhage, dysmenorrhea, endocervicitis. Dangers: Sepsis, perforation of uterus, hemorrhage, abortion, inflam- mation of uterus, or adnexa. Procedure: All antiseptic and 106 MEDICAL RECORD. aseptic precautions are necessary, the patient should be in the dorsal position, the vagina is to be disinfected, and the cervical canal dilated ; a speculum is introduced into the vagina and the cervix is drawn down with volsella ; the uterine cavity is irrigated with creolin or lysol ; a curette is inserted to the fundus and moved down to the internal os; the operator should begin at one cornu and go in the same direction all around till he reaches the starting point, and if necessary repeat till no more spongy or hyperplastic tissue appears ; the fundus should be scraped separately by moving the curette along it from side to side; in going towards the fundus no scraping should be done, and care must be taken not to perforate the uterus; should this hap- pen no fluid must be injected; otherwise the uterus and vagina are again irrigated, and one or more strips of iodo- form gauze are inserted into the cavity to act either as a hemostatic plug or as a drain, which is diminished with two days' interval and withdrawn on the sixth day. A hemostatic tampon should be placed in the vagina and withdrawn the following day. If any fever arises, the tampon is at once removed and the vagina douched with antiseptic fluid every three hours. If not, the vagina is only swabbed with the same every day, and packed loosely with iodoform gauze. After the final removal of the gauze the antiseptic douche is given twice a day until there is no more discharge. The patient should remain in bed for a week. 9. See Williams' "Obstetrics" (1909), pages 818 and 821; or Hirst's "Obstetrics" (1909), pages 585 and 587. 10. "A prolapsed uterus must first be placed in proper position, or a procidentia reduced. In many cases the introduction of a rubber ring pessary will then suffice to prevent recurrence. But it will often be found necessary to repair a torn perineum, removing at the same time redundant portions of the vaginal walls, before the ring will remain in the vagina. When such an operation is con- traindicated, and the vaginal orifice is so wide that a ring cannot be kept in, some form of pessary with a vaginal stem and perineal bands will be required. In cases of pro- cidentia, where the exposed surface is much ulcerated, the patient should be kept in bed, emollient applications made to the ulcers, and vaginal douches given. When the ulcers have healed, a pessary may be introduced. Procidentia due to supravaginal elongation of the cervix must be differently dealt with. Amputation of a portion of the cervix must therefore form the first step in the treatment, and it may be required also when the hyperplasia is secondary to descent. Cases of prolapse and procidentia which resist milder measures require further operative procedures, such as ventrofixation of the uterus or the shortening of the 107 MEDICAL RECORD. round ligaments. It is in cases of this kind that hys- teropexy has often given satisfactory results. Total ex- tirpation of the uterus has been advised and practised for the treatment of procidentia." — (Sutton and Giles' Dis- eases of Women.) SURGERY. i. See Rose and Carless' "Surgery" (1908), pages 307, 308, 310, and 311; or Da Costa's "Surgery" (1908), pages 359, 356, and 361. 2. See Rose and Carless' "Surgery" (1908), pages 399 and 400; or Da Costa's "Surgery" (1908), page 1057. 3. See Rose and' Carless' "Surgery" (1908), page 1318; or Da Costa's "Surgery" (190&), page 1047. 4. "The portable instrument of Janeway is accurate and practical because of its broad arm piece, which excludes the errors (high readings) inherent in the narrow compression bands when applied to unusually fat or muscular arms, and because of its accurate regulation of pressure by a stop- cock. Technique: The hollow armlet applied midway be- tween shoulder and elbow is inflated by the hand bulb until the radial pulse is lost, then by the outlet thumb- screw the pressure is lowered until the pulse return is just perceptible. As the pressure is equal in all parts of the closed system, the height of the mercury column in the manometer tube is an exact index, and the reading repre- sents the 'maximum' or 'systolic' pressure. 'Diastolic' or 'minimum' pressure is determined by noting for ten or twelve pulsations the increasing amplitude of the pulse wave registered by the mercury column as the pressure is reduced in 5-mm. series. The point causing maximum excursion is the index of diastolic pressure. Below that is a limited pressure area of equal amplitudes. The 'mean' pressure represents the average of systolic and diastolic readings. Diastolic readings run about 25 to 40 below systolic, and in low tension vary 50 to 80, and in regurgita- tion up to 100 mm. A loose band or a rapid or excessively small pulse makes diastolic pressure determination im- possible, and in every case the arm band should be closely adjusted, the arm supported at the heart level and the same position taken for a series of tests. The limit of error in calcareous arteries is but 5 to 10 mm., and is negligible or easily estimated. The same figures represent the difference between females and and sitting posture. In normal pressure four factors are concerned, viz., the initial heart energy, peripheral resistance, blood volume, and the elasticity of the vessels. The normal readings, according to Janeway, are : For young adults, 100 to 130; older adults, 100 to 145; children, 90 to no; infants under two years, 75 to 90. Excitement 108 MEDICAL RECORD. may cause a rise of 40 mm., and concentrated physical effort a slight increase.'' — (Greene's Diagnosis.) 5. The blood pressure is an indication of the degree of shock; in severe operations it is generally lowered below 100 mm. ; and below 80 mm. is supposed to be indicative of danger. It is not in general use but is (theoretically) of value. 6. See Gray's "Anatomy" (1908), page 494; or Rose and Carless' "Surgery" (1908), page 247. 7. In fracture of the neck of the femur, the head of the femur will be found in the acetabulum; in dislocation, the acetabulum will be empty, and the head of the femur will be found elsewhere, e.g. on the dorsum of the ilium. In the fracture, crepitus may be elicited; in the dislocation, never. In the dislocation there is inversion and a fixed position of the limb, both of which are absent in fracture. 8. See Rose and Carless' "Surgery" (1908), pages 494 and 495 ; or Da Costa's "Surgery" (1908), page 482. 9. See Rose and Carless' "Surgery" (1908), pages 1152 and 1153; or Da Costa's "Surgery" (1908), page 1015. 10. (a) Varieties of carcinoma: (1) Glandular or spher- oid carcinoma. (2) Squamous carcinoma. Synonyms, epithelioma; squamous epithelioma. (3) Rodent cancer or rodent ulcer. (4) Columnar carcinoma. Synonyms, col- umnar epithelioma; adenoid cancer. (5) Thyroid carcino- ma (resembling in structure the thyroid gland). — (From Gould and Pyle's Cyclopedia.) (c) By the lymphatics. For (b) and (►. S rt c3 So U *a5 ea 00 bo |JS ^ r3 p 'age « E en — . tn Si? cd 03 ^ U - T3 3 O S e a w S w p> o -c « ■S"s w £ ; s | ,«° — ,i+^ o . ^.2 « « w o.^w 3 .9. o 149 to B c C3 (U is c c £ 'C.2 ^ ^-" O ~* W. S. r- c -^ -- S ? O rt ° *^ c St t So *> v - C ^•p O U O i_ k.^ in ^-^ MEDICAL RECORD. 4. The area of liver dullness is shown in the table (from Hutchison and Rainy's Clinical Methods) : Upper limit Deep dullness Superficial dullness Middle Line Lower limit Blend with heart dulness Hand's -breadth below base of xiphoid Mammary Line 4th space 6 th rib Costal mar- gin or some- what above or below it Mid-axil- lary Line 7th space 8th rib 10th space Scapular Line 9th space 10th rib Blends with kidney dulness Chronic diseases of the liver: Chronic hyperemia, chronic interstitial hepatitis (cirrhosis), echinocoqcus cyst, chronic perihepatitis, gallstones, amyloid liver, chronic atrophy, fatty liver, syphilis of liver. 5. See French's "Practice of Medicine" (1907), pages 315 to 325; or Osier's "Practice of Medicine" (1909), pages 130 to 140. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), pages 493 and 380. 2. See Williams' "Obstetrics" (1909), page 904; or Hirst's "Obstetrics" (1909). page 647. 3. See Hirst's "Obstetrics" (1909), pages 728 to 752, and 764 to 766. 4. For eclamptic convulsion see Williams' "Obstetrics" (1909), page 525; or Hirst's "Obstetrics" (1909), page 630. Epilepsy is not accompanied by albuminuria, has different prodromata, there is no rise of body temperature, and there is apt to be a history of previous attacks. 5. Indications for the use of forceps are : "1, Forces at fault: Inertia uteri in the presence of conditions likely to jeopardize the interests of mother or child, (a) Impend- ing exhaustion; (b) arrest of head, from feeble pains. 2. Passages at fault: Moderate narrowing, 3% to 3.% inches, true conjugate; moderate obstruction in the soft parts. 3. Passenger at fault: A. Dystocia due to (a) occipito- posterior, (b) mentoanterior face, (c) breech arrested in cavity. B. Evidence of fetal exhaustion (pulse above 160 or below 100 per minute). 4. Accidental complications: Hemorrhage ; prolapsus funis ; eclampsia. _ All acute or chronic diseases or complications in which immediate de- livery is required in the interest of mother or child, or both."— (From Jewett's Practice of Obstetrics.) GYNECOLOGY. i. The following (from Gould and Pyle's Cyclopedia of 150 MEDICAL RECORD. Medicine and Surgery) is a useful classification of uterine hemorrhages, and also gives the causes of the same : 1. Hemorrhages complicating pregnancy, labor, or the puerperium: A. Hemorrhages of pregnancy: Caused by (i) placenta praevia; (2) premature separation of a normally situated placenta; (3) apoplexy of the decidua or placenta. B. Hemorrhages of labor: Caused by (1) placenta previa; (2) premature separation of a normally situated placenta; (3) relaxation of the uterus; (4) laceration of the cervix; (5) rupture or inversion of the uterus. C. Hemorrhages of the puerperium: Caused by (1) re- tained secundines; (2) displaced uterus; (3) displaced thrombi; (4) fibroid tumors; (5) r^pertrophied decidua; (6) carcinoma. II. Hemorrhages occurring in the non-pregnant woman: A. In virgins before the age of thirty: Caused by (1) uterine congestion, the result of cold or exposure; (2) endometritis; (3) polypi and fibroid tumors. B. In married women before the age of thirty: Caused by (1) subinvolution; (2) laceration of the cervix; (3) endometritis; (4) retrodisplacements of the uterus; (5) polypi and fibroid tumors. C. In women after the age of thirty: Caused by (1) carcinoma of the cervix ; (2) carcinoma of the body of the uterus; (3) sarcoma of the uterus. The treatment depends on the cause. For details see any work on obstetrics or gynecology. 2. The indications for hysterectomy are given as fol- lows : For the abdominal operation: All solid or cystic tumors of the uterus ; cancer ; uterine rupture during labor ; certain conditions of puerperal sepsis; pregnancy compli- cated by pelvic deformity, cancer, or other serious obstacle to the passage of the child ; uterine prolapse or inversion, and, incidentally, as a step in the removal of complicated suppurative conditions of the uterine appendages. For the vaginal operation: Bilateral suppurative condi- tions of the appendages; prolapse, cancer, pregnancy with cancer before the sixth month ; certain septic conditions of the uterus ; certain rare conditions which may require the ablation of a small movable uterus. For the combined operation: Cancer, certain compli- cated fibroids; failure to secure hemostasis from below. — (From Reference Handbook of the Medical Sciences.^ 3. Vaginal hysterectomy: 'The patient is catheterized and placed in the lithotomy position and the external geni- tals are thoroughly disinfected. The vagina is held open by broad retractors and the uterus is pulled down by vol- sella forceps grasping the cervix, while the adjoining mu- cous membrane is cut well clear of the disease by blunt- 151 MEDICAL RECORD. pointed scissors. Keeping close to the uterus, the dissec- tion is continued on its anterior and posterior surface by the tip of the finger and short snips of the scissors, but at the sides, after division of the mucous membrane, the cel- lular tissue is simply pushed up as high as possible, or till the pulsations of the uterine artery are felt. The finger is finally thrust through the uterovesical fold of peritoneum, and after cleansing the vagina flat sponges are poked in around the uterus. Douglas' pouch is entered in the same manner, hemorrhage from the vaginal wound being con- trolled by a few catgut sutures through its cut edges, and then the finger is hooked over the fundus, pulling it down into the posterior opening and thus bringing within reach the upper border of the broad ligaments, which are seized by long-bladed clamps and divided on the uterine side. Other clamps are placed on the remaining tissues close to the uterus, which is then excised." — (Stimson's Operative Surgery.) 4- ASCITES. i. Previous history of visceral disease. 2. Enlargement compara- tively sudden. 3. Face puffy ; color waxy ; early anemia. 4. Patient on back; en- largement symmetrical; flat in front. 5. Sitting up, abdomen bulges below. 6. Navel prominent and thinned. 7. Fluctuation decidedly clear, diffuse throughout abdomen, but avoids highest parts in all positions, and al- ways has a hydrostatic level. 8. Intestines float on top of fluid ; hence percussion gives clear tympanitic note over the highest parts of abdominal cavity, and dull- ness in lowest parts for all positions, i.e. areas of res- onance and dullness change with position. 9. Vaginal touch detects fluctuation, bulging into va- gina. OVARIAN CYST. 1. No such history. 2. Gradual. 3. Facies ovarian. Ane- mia absent, or later. 4. Asymmetrical until tu- mor is quite large; promi- nent in front. 5. No appreciable change. 6. Navel usually un- changed. 7. Less clear; limited to cyst; not modified by change of position. No hydrostatic level. 8. No change in areas of dullness and resonance with change of position. Dull- ness over cyst. Clear reso- nant note in all parts beyond cyst limits, i.e. in flanks and toward the diaphragm. 9. Vaginal fluctuation less clear or absent. 152 MEDICAL RECORD. ASCITES. OVARIAN CYST. io. Uterus in prolapsed location, but position un- changed. Size and mobility unchanged. it. Hydragogues and diu- retics temporarily remove the fluid. 12. Fluid light straw color and thin. Coagulates spon- taneously. 10. Uterus displaced for- ward or backward, or later- ally by pressure of cyst. 11. Medicines have no ef- fect. 12. Fluid light or dark and of varying consistency; albuminous, but does not coagulate spontaneously ; mav contain colloid matter. — (From Dudley's Gynecology.) 5. See Williams' "Obstetrics" (1909), page 62s; or Hirst's "Obstetrics" (1909), page 284. SURGERY. 1. Conditions which justify amputation of a limb are: "Any injury, disease, or malformation rendering retention of the limb incompatible with life or comfort; avulsion of limb; compound fracture; compound dislocation; fracture with great comminution of bone; laceration of important vessels ; extensive contusion ; extensive laceration ; gunshot injuries; aneurysm; effects of heat and cold; gangrene; ex- tensive bone disease; tumors; elephantiasis; tetanus; snake bite; deformities." — (Bickham's Operative Surgery.) Amputations are classified in regard to time of operating, as follows: (1) Primary, which is performed soon after the accident, as soon as the patient reacts from shock and before there is any fever. (2) Secondary, which is under- taken some time after the injury, when suppuration or bone or joint disease have supervened. (3) Intermediate, which is performed during the existence of the fever, but before suppuration or bone or joint disease have appeared. The most favorable period of amputating is after moder- ate reaction has been established; in the primary period. See Da Costa's "Surgery" (1908), page 1221. In a cross section of the thigh, at the middle third, there are severed : Muscles, Vastus internus, Rectus femoris, Cru- reus. Vastus externus, Biceps, Semitendinosus, Semimem- branosus, Gracilis, Sartorius, Adductor magnus : Arteries, superficial femoral, anastomotic, deep femoral, perforating. 2. See Rose and Carless' "Surgery" (1908), pages 1068, 1073, 1096, 1 100, 1 103, and 1081 ; or Da Costa's "Surgery'' (1908), pages 971, 999, 994, and 978. 3. See above, Practice of Medicine, No. 3. For erysip- elas, see Rose and Carless' "Surgery" (1908), pages 119 and 122; or Da Costa's "Surgery" O908), page 200. 153 MEDICAL RECORD. FRACTURE. 1. Crepitus may be present. 2. Preternatural mobility. 3. Easily reduced — but 4. Deformity more liable to recur after reduction. 5. The head of the bone is in its proper place. 6. The socket containing the head of the bone is not empty. 7. When rotated the bone does not move as one piece. DISLOCATION. 1. Crepitus never present. 2. Rigidity rather than mo- bility. 3. Difficult to reduce— but 4. Deformity less liable to recur after reduction. 5. The head of the bone is not in its proper place. 6. The socket which should contain the head of the bone is empty. 7. When rotated the bone moves as one piece. The cardinal principles in the treatment of fractures are : Reduction, coaptation, immobilization, and suitable measures for promoting the nutrition of the part and for preventing adhesions in the neighboring joints and mus- cles. Compound fractures, in addition, demand : Asepsis, removal of foreign matter or damaged tissues, stopping the hemorrhage, and measures to combat shock. 4. Inflammatory diseases of bone: Osteitis, periostitis, osteoperiostitis, and osteomyelitis. For ankylosis, see Rose and Carless' "Surgery" (1908), pages 676 and 678; or Da Costa's "Surgery" (1908), pages 575 and 576. For club- foot, see Rose and Carless' "Surgery'' (1908), page 450; or Da Costa's "Surgery" (1908), page 662. 5. For abscess and aneurysm, see Rose and Carless' "Surgery" (1908), page 311; or Da Costa's "Surgery" (1908), page 361. Hydrocele: Is pyriform in shape; the swelling is first noted at the lowest part of the scro- tum ; it is tense, smooth, and fluctuates ; it is dull on per- cussion; it is translucent; the testicle is behind the tumor; there is no impulse on coughing. Scrotal hernia: Is sausage-shaped; the swelling begins above; it is not translucent; the testicle is below the tumor; there is an impulse on coughing, as a rule. — {Treatment of Hydro- cele.) See Rose and Carless' "Surgery" (1908), page 1267; or Da Costa's "Surgery" (1908), page 1201. Method of controlling hemorrhage: Mechanical, elevation, pres- sure, torsion, ligation, compression, acupressure, and forced flexion of limb. Therapeutic, heat, cold, styptics, and the cautery. The constitutional symptoms must also be treated : lower the head, inject normal salt solution, ad- minister alcohol, strychnine, digitalis, morphine. For sec- ondary hemorrhage: See Rose and Carless' "Surgery" (1908), page 290; or Da Costa's "Surgery" (1908), page 394- 154 MEDICAL RECORD. STATE BOARD EXAMINATION QUESTIONS. Idaho State Medical Licensing Board. anatomy. i. Give the deep and superficial origin, course, and dis- tribution of the pneumogastric nerve. 2. What constitutes the brachial plexus? 3. Give the origin, insertion, and nerve supply of the (a) longest and (b) shortest muscle in the body. 4. Name the flexor muscles of the forearm and describe one of them. 5. Describe the sternum, its articulations, and the im- portant muscles attached to it. HISTOLOGY. 1. From what primary layer is the nervous system de- veloped? The peritoneum? The mucous membrane? The kidneys? The teeth? 2. What are the following: Corpus luteum? Macula lutea? Loop of Henle? Paccinian bodies? Stomata? 3. Describe the structure of the thyroid gland. 4. Mention all the histological bodies found in normal blood. 5. Name the layers of the retina. PHYSIOLOGY. 1. Name the reflex centers of the medulla oblongata. 2. Is there any localization in the cerebellar cortex? 3. Name and give the location of the several sympa- thetic ganglia. 4. Name the principal secreting organs and the general types of structure. 5. What change takes place in the blood during its passage through the capillaries of the lungs? 6. Define external and internal secretions, and give an example of each. 7. Define proteoses and peptones, and say by what process those products are evolved during digestion. 8. Describe the structure of the uterus. 9. Give all the causes of contraction of the pupil. 10. Describe the act of deglutition. By what nerve centers is the process controlled? CHEMISTRY AND TOXICOLOGY. i. Give the chemical name and formula of (a) common salt, (b) marble, (c) plaster-of-paris, (d) borax, (e) blue vitriol, ■(/) sulphate of iron. 2. Give the symbol, atomic weight, and valence of five non-metals and of five metals. 155 MEDICAL RECORD. 3. Define molecular weight and molecular volume. Give an example of each. 4. Describe two experiments showing the difference between mechanical and chemical action. 5. Which is the most abundant element? Name the elements represented by the following symbols : K, Na, Ni, Si, Sb, S, Mg, Pb, Cu, Hg, Ag, Co, Mn, F, P. 6. How may poisons be classified? Give the manner of action of each class. 7. What is the difference between ptomains and leuco- mains? Give example of each. 8. Describe symptoms of toxic doses of strychnine, morphine, strophanthus, hydrocyanic acid, and aconite. 9. What antidotes should be used in phosphorus poison- ing? Explain the action of each. 10. What is the chemical treatment for carbolic acid poisoning? PATHOLOGY. 1. Define and describe thrombosis, embolism, metastasis, necrosis. 2. What is amyloid degeneration? In what organs does it generally occur? 3. Describe the process of parenchymatous inflammation. 4. Decribe the bacillus of tuberculosis. Describe a tubercle. 5. State the pathology of fibrinous or lobar pneumonia. 6. Give the pathological lesions of typhoid fever. 7. Give the pathology of chronic interstitial nephritis. 8. Describe the skin lesions occurring in psoriasis. 9. Locomotor ataxia; give its pathology. 10. What changes occur in the red blood corpuscles in progressive pernicious anemia? DIAGNOSIS. 1. Tuberculin tests ; give description of, uses, and results. 2. Give diagnosis of acute pancreatitis. 3. Differentiate choleocystitis and cholangitis. 4. Differentiate nephrolithiasis, chronic parenchymatous nephritis, and chronic interstitial nephritis. 5. Give blood findings in anemia. 6. Name three diseases caused by microorganisms, de- scribe each organism, and give method of staining. 7. Differentiate between chronic pneumonia and tuber- culosis of the lungs. 8. Give concise description of the heart murmurs, where found. 9. Differentiate between cerebral and gastric vomiting. 10. (a) Describe Hutchinson's teeth and state in what disease they are most commonly found. (b) What is 156 MEDICAL RECORD. Babinski's sign? (c) Koplik's spots? (d) Cheyne-Stokes respiration; when found? THEORY AND PRACTICE. i. Give methods of feeding infants who are deprived of mother's milk. 2. Stomatitis, varieties, symptoms, diagnosis, and treat- ment. 3. Give short description of serum therapy and name diseases in which it has been successfully employed. 4. Give etiology, symptoms, prognosis, diagnosis, and treatment of acute ileocolitis. 5. Give etiology, symptoms, diagnosis, prognosis, com- plications, and treatment of typhoid fever. 6. Same of gonorrheal arthritis. 7. Same of tabes dorsalis. 8. Same of cerebrospinal meningitis, including micro- scopic specimen; how obtained and findings. 9. Describe bronchiectasis, give symptoms, physical signs, and treatment. 10. Give etiology, symptoms, prognosis, diagnosis, and treatment of rachitis. OBSTETRICS. 1. Give diagnosis of cystic degeneration of the chorion; treatment; prognosis. 2. Give mechanism of labor, vertex presentation. 3. Give presumptive and positive signs of pregnancy. 4. Give management of lateral placenta prsevia. 5. Give management of threatened abortion ; treatment of complete abortion. 6. How diagnose ectopic pregnancy? 7. What conditions would necessitate (a) version, (b) Cesarean section, (c) forceps delivery? 8. Why is it necessary hastily to deliver the head in breech or foot presentations? . 9. What is the cause of phlegmasia alba dolens? 10. How diagnose and treat invertion of the uterus? GYNECOLOGY. 1. Give the etiology, symptoms, and treatment of acute pelvic peritonitis. 2. Give the etiology, symptoms, and treatment of acute ovaritis. 3. _ Make a differential diagnosis between ascites and ovarian cyst. 4. Give the symptoms and treatment of membranous dysmenorrhea. 5. Define and give the etiology and symptoms of pelvic hematocele. 157 MEDICAL RECORD. 6. Give the etiology, symptoms, and treatment of abscess of the vulvovaginal gland. 7^ Describe the symptoms of salpingitis. Name the va- rieties of salpingitis according to the tubal contents. 8. Give the symptoms and treatment of urethral car- uncle. 9. Describe the symptoms and treatment of a recto- vaginal fistula. io. Give the symptoms and treatment of gonorrheal vaginitis. Name the complications. SURGERY. i. Define asepsis; mention a few of the best antiseptics. 2. Mention five common suture materials and tissues best joined by each. 3. Write less than two hundred words, stating your practice with regard to drainage. 4. Give treatment for paronychia, hordeolum, empyema. 5. How would you diagnose cystic calculi? 6. Give the differential diagnosis of appendicitis. 7. How treat peritonitis? 8. Give treatment for ingrowing toenail; treatment for actinomycosis. 9. Mention surgical complications of typhoid fever. 10. J What is appendicostomy, dactylitis, osteomyelitis, Dubois' abscess, hysterotrachelorrhaphy? HYGIENE. i. Name the principal constituents of soil and its physical properties. 2. Define tilth, marl, loam, humus, peat, muck, and state which of those soils will retain the greatest amount of water, and which is most inimical to pathogenic organisms. 3. To what average depth is soil self -purifying, by what natural agents is the work accomplished, and how do the dwellers on the soil retard it? 4. Name the different sources of our water supply and its sanitary classification. 5. How may a well be polluted by a cessrjool on a lower level or remain unaffected by one on higher ground? Answer by diagram if you wish. 6. Describe an ordinary filter bed for the purification of water, and say what is the fundamental principle of Dibdin's bacteria beds, and Cameron's septic tank. 7. Do we inspire and expire microorganisms? 8. Describe the atmospheric conditions desirable for the support of human life. 9. What effect upon the blood results from the inhala- tion of carbon monoxide and what per cent, by volume is fatal to animal life? 158 MEDICAL RECORD. io. Tabulate the conditions of hygienic interest with regard to various employments. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Idaho State Medical Licensing Board. anatomy. 1. Pneumogastric nerve. Superficial origin: Groove between restiform and olivary bodies. Deep origin: Nuclei in floor of fourth ventricle. Course: Outward across the flocculus, to jugular foramen through which it passes, here it is joined by the accessory portion of the spinal accessory nerve. As it goes down the neck it lies in front of the rectus capitis anticus major and longus colli muscles. It passes in the carotid sheath behind and between the artery and vein. In the thorax the nerve on each side runs a different course. The right passes between the subclavian artery and vein, by side of trachea to root of lung, behind esophagus, through esophageal opening in diaphragm to posterior surface of stomach. The left passes between the subclavian and carotid arteries, in front of arch of aorta to root of lung, along anterior surface of esophagus, through diaphragm, to anterior surface of stomach. Dis- tribution is shown by the names of the branches: Menin- geal, auricular, pharyngeal, superior and inferior laryngeal, cardiac, pulmonary, esophageal, and gastric. 2. The brachial plexus is formed by the union and subse- quent division of the anterior divisions of the fifth, sixth, seventh, and eighth cervical and the first dorsal nerves. The union of the fifth and sixth makes the upper trunk; the seventh forms the middle trunk, and the eighth cervical and first dorsal make the lower trunk. Each of these trunks is divided into an anterior and a posterior branch. The auterior branches, from the upper and middle trunks, make the upper or outer cord of the plexus ; the anterior branch of the lower trunk becomes the lower or inner cord; the three posterior branches unite to form the posterior or middle cord. The plexus lies between the Scalenus anticus and medius. The branches are: (i) Above the clavicle; communicating, muscular, posterior thoracic, and supra- scapular. (2) From outer cord: External anterior thoracic, musculocutaneous, and outer head of median. (3) From inner cord: Internal anterior thoracic, lesser internal cuta- neous, ulnar, and inner head of median. (4) From pos- terior cord: Subscapular, circumflex, and musculospiral. 3. Longest muscle in body is Sartorius. Origin: An- terior superior spine of ilium, and notch below. Insertion: 159 MEDICAL RECORD. Inner and upper part of shaft of tibia. Nerve supply: An- terior crural. Shortest muscle is probably Stapedius. Origin: Pyramid of tympanum. Insertion: Neck of stapes. Nerve supply: Facial. 4. Biceps, brachials anticus, supinator longus, pronator radii teres. The Supinator longus arises from the upper two-thirds of the external supracondylar ridge of the hu- merus, and is inserted into outer side of the base of the styloid process of the radius. It is superficial for most of its extent; it is supplied by the musculospiral nerve. Be- sides being a flexor of the forearm, this muscle acts both as a pronator and supinator ; it tends to bring the bones of the forearm into a position midway between pronation and supination. 5. The Sternum is a flat, narrow bone, situated in the median line of the front of the thorax. It consists of three portions : Manubrium, gladiolus, and ensiform. It is about seven inches long. At the junction of the first two pieces is the angle of Ludovic; and here the second costal carti- lage joins the bone. It articulates with the clavicle and seven costal cartilages on each side. Muscles attached are : Pectoralis major, sternomastoid, sternohyoid, sterno- thyroid, diaphragm, triangularis sterni, and aponeuroses of external oblique, internal oblique, rectus abdominis, and transversalis. HISTOLOGY. 1. The nervous system is developed from the epiblast; the peritoneum, from mesoblast; mucous membrane, from epiblast and hypoblast; kidneys, from mesoblast; teeth, the enamel from the epiblast, dentine from the mesoblast. 2. Corpus luteum is a yellow body formed in the ovary at the site where an ovum has been discharged from a Graafian follicle. Macula lutea is a yellow depressed spot at the center of the retina; vision is most acute here. Loop of Henle is a part of the convoluted uriniferous tubule of the kidney. Pacinian bodies are ovoid, laminated bodies surrounding the termination of certain nerves in the skin and mesentery and corpora cavernosa. Stomata are minute orifices between endothelial (and other) cells. 3. The thyroid gland "is surrounded by a capsule that sends in trabecule, which divide the gland into lobes and lobules. These divisions are irregular, and the lobules are composed of a number of short tubules, sometimes called follicles. Each tubule is lined by cuboidal epithelial^ cells that rest upon a basement membrane ; outside of this is the intralobular, or intertubular, connective tissue that supports the blood-vessels. In the tubules is seen a peculiar, homo- geneous substance, the colloid substance, that is supposedly the result of the activity of the cells. It has a yellowish 160 MEDICAL RECORD. color, and as blood cells are frequently seen in it, the color may be due to the hemoglobin from these." — (Ra- dasch's Compend of Histology.) 4. Ked corpuscles; white corpuscles (small mononuclear, large mononuclear, transitional, polynuclear, esinophile) ; platelets. 5. (1) Layer of pigment cells; (2) layer of rods and cones; (3) the external limiting membrane; (4) the outer nuclear, or granular, layer; (5) the outer molecular, or reticular, layer; (6) the inner nuclear, or granular, layer; (7) the inner molecular or reticular layer; (8) the layer of ganglion cells; (9) the layer of nerve fibers; and (10) the internal limiting membrane. PHYSIOLOGY. 1. (1) Center for mastication, (2) for secretion of saliva, (3) for sucking, (4) for deglution, (5) for vomit- ing, (6) for voice, (7) center for expression, (8) cardiac centers, (9) respiratory centers, (10) vasomotor centers. 2. Strictly speaking, there is no localization. 3. Ganglion of Ribes, on anterior communicating artery. Superior cervical, in front of the transverse processes of the second and third cervical vertebrae. Middle cervical, opposite sixth or seventh cervical vertebra, and in relation with inferior thyroid artery. Inferior cervical, over back of first rib, and beneath vertebral artery. First thoracic, beneath head of first rib; sometimes blends with inferior cervical. Second to eleventh thoracic, on heads of ribs, under cover of pleura. Twelfth thoracic, on side of twelfth thoracic vertebrae, behind diaphragm. Four lumbar ganglia, in front of bodies of lumbar vertebrae, on inner side of psoas, and being overlapped by aorta and inferior vena cava. Four sacral ganglia, on inner side of anterior sacral foramina. Ganglion impar, in front of coccyx. Also ophthalmio ganglia, at back of orbit. Sphenopalatina, in sphenomaxillary fossa. Otic, below foramen ovale. Sub- maxillary, above submaxillary gland and behind mylohyoid muscle. 4. Liver, pancreas, salivary glands, intestinal glands ; sweat, and sebacceous glands ; testes, Cowper's glands, mam- mary glands ; lacrymal glands ; small gland in respiratory tract; ductless glands (spleen, thyroid, thymus, and supra- renals). General types of structure: I. Simple glands. — Duct undivided, (a) Simple tubular: Undilated at end. (b) Simple acinous (alveolar or saccular): Dilated at end. II. Compound glands. — Duct divided. (a) Compound tubular: Branched elongated tubes, no acini, (b) Com- pound acinous or alveolar (racemose glands), branched duct with saccular acini on terminal branches, (c) Acino- 161 MEDICAL RECORD tubular. — Branched duct, with elongated narrow acini on terminal branches. 5. (1) The giving up of the C0 2 by the venous, blood, (2) the absorption of oxygen during inspiration, (3) cool- ing of the blood, (4) loss of a small amount of watery vapor, (5) the color becomes red. 6. External secretions are such as are carried off from the secreting gland by a duct; as, the bile. Internal secre- tions are such as are not carried off by a duct, but are discharged into the blood or lymph; as, the secretion of the thyroid (or other ductless glands). 7. Proteoses are intermediate products between proteids and peptones. Peptones are the final product of digestion of proteids. They are both evolved by the action of the pepsin of the gastric juice, and the trypsin of the pan- creatic juice, during the digestion of proteids. 8. See Cunningham's "Anatomy" (1909), page 1187; or Gray's "Anatomy" (1908), page 1498. 9. (1) Stimulation by light; (2) stimulation of third cranial nerve; (3) paralysis of cervical sympathetic; (4) accommodation for near objects; (5) sleep; (6) myotic drugs, such as opium; (7) turning inwards of the eyeball. 10. Deglutition: "The masticated food is gathered up by the tongue and formed into a bolus between the tongue and the hard palate. The tongue is then pressed from be- fore backwards against the roof of the mouth, and the bolus slips back, through the fauces, and is ultimately grasped by the pharyngeal muscles, and passed into the esophagus. The act of deglutition is divided into three stages : "The first stage is a voluntary act, by which the food is carried back to the anterior pillars of the fauces. The second stage consists in the passage of the bolus from the anterior pillars of the fauces to the commence- ment of the esophagus; this is a reflex act, and is per- formed very rapidly, as the food has to pass over the opening of the larynx. As soon as the bolus arrives at the isthmus of the fauces, the pharynx is prepared for its re- ception. The hyoid bone is drawn forwards and upwards, so that the larynx is protected by the base of the tongue, which projects over it; the epiglottis^ being closed at the same time, and the vocal cords approximated so as to close the rima glottidis. The pharynx itself is shortened and drawn forward by the contraction of the palato-pharyngei muscles ; the soft palate is also raised and made tense, thus cutting off the upper part of the pharynx and posterior nares, and forming an incline under which the bolus is passed into the pharynx. This passage is effected by the elevation of the hyoid bone and the base of the tongue, and the simultaneous contraction of the pillars of the fauces. The bolus is then seized and carried rapidly down past the 162 i MEDICAL RECORD. larynx by the pharyngeal constrictors. The third stage of the act of deglutition is due to the peristaltic contractions of the esophagus." The nerve centers are in the medulla. CHEMISTRY AND TOXICOLOGY. (a) Common salt (&) Marble (c) Plaster of Paris.. (d) Borax (e) Blue vitriol (/) Sulphate of iron. . 2. CHEMICAL NAME. Sodium chloride Calcium carbonate Calcium sulphate Disodic tetraborate Cupic sulphate Ferrous sulphate FORMULA. NaCl CaCOs CaSO* Na 2 B 4 7 CuSO* FeSO* SYMBOL. ATOMIC WEIGHT. VALENCE. Five non-metals: i. Hydrogen 2. Oxygen 3. Nitrogen 4. Fluorine 5. Chlorine Five metals: 1. Mercury 2. Copper 3. Aluminum H N F CI Hg Cu Al Au Ag I 16 14 19 35.5 200 63 27 197 I08 I 2 3 or 5 1 1 2 2 3 1 or 3 1 4. Gold 5. Silver 3. Molecular weight is the weight of a molecule of a substance as compared with the weight of an atom of hydrogen. It may also be said to be the sum of the weights of the atoms composing the molecule. Thus, the molecule weight of sulphuric acid, H 3 S0 4 is (2 + 32 + 64), that is, 98; or 98 times the weight of an atom of hydrogen. Mole- cule volume is the molecular weight divided by the specific gravity. 4. "When a cylinder of lime is strongly heated it be- comes white hot and emits light; it is still lime, however, after the action of the heat, as it was before. This is a physical phenomenon. If, now, we throw this lime into hydrochloric acid it disappears, and, after the action has been completed, we find neither lime nor hydrochloric acid, but two new substances, one a solid, called calcium chlorid, the other a liquid — water; both of which differ in their composition from the original substances, which have disap- peared. This is a chemical phenomenon." 5. The most abundant element is oxygen. K is potas- 163 MEDICAL RECORD. sium ; Na, sodium ; Ni, nickel ; Si, silicon ; Sb, antimony ; S, sulphur ; Mg, magnesium ; Pb, lead ; Cu, copper ; Hg, mercury; Ag, silver; Co, cobalt; Mn, manganese; F, fluor- ine; P, phosphorus. 6. Poisons may be classified as: (i) Mineral, (2) vege- table, (3) animal, and (4) synthetic. 7. Ptomains are basic, nitrogenous compounds, produced from protein material by the bacteria which cause putre- faction. Examples: Cadaverin, and putrescin. Lencomains are similar substances produced in living animals during normal metabolism. Examples: Xanthin and hypoxanthin. . 8. The symptoms of strychnine poisoning are as follows : A sense of suffocation, thirst, tetanic spasms, usually opis- thotonos, sometimes emprosthotonos, occasionally vomiting, contraction of the pupils during the spasms, and death, either by asphyxia during a paroxysm or by exhaustion during a remission. The symptoms of poisoning by mor- phine are as follows : At first there is usually a period of excitation, marked by restlessness, great physical activity, loquacity, and hallucinations. The patient then becomes weary, dull, and drowsy; he yields to the desire for sleep, from which at first he may be roused. The lips are livid, the face pale, the pupils contracted, and the surface bathed in perspiration. The condition of somnolence rapidly passes into narcosis. The patient cannot be roused, and lies motionless and senseless, with completely relaxed mus- cles. The pulse, at first full and strong, becomes feeble, slow, irregular, and easily compressible ; the respiration slow, shallow, stertorous, and accompanied by mucous rales. The patient rapidly becomes comatose, and in fatal cases, dies in from 45 minutes to 56 hours, usually in from 12 to 18 hours. Strop hanthus causes : Nausea, colic, diar- rhea, slow pulse, dyspnea, headache, vertigo, cold extremi- ties, drowsiness, and syncope. Hydrocyanic acid causes : Constriction of throat, vertigo, mental confusion, loss of muscular power, quick pulse, slow respirations, tetanic con- vulsions, loss of control of sphincters, and paralysis. Aconite causes: Numbness and tingling, first of the mouth and fauces, later becoming general. Dryness and constric- tion in the throat. Persistent vomiting usually occurs, but is absent in some cases. There is diminished sensibility, with numbness, great muscular feebleness, giddiness, loss of speech, irregularity and failure of the heart's action. 9. Antidotes to phosphorus are: Old French oil of tur- pentine and potassium permanganate. The latter acts as an oxidizing agent. Fats and oils must not be given, as they would help in the absorption of the phosphorus. 10. For carbolic acid poisoning: Give sodium sulphate, or magnesium sulphate, or albumin ; follow this with lavage. Alcohol is also recommended. 164 MEDICAL RECORD. PATHOLOGY. i. Thrombosis is the coagulation of the blood within the vessels during life. Embolism is the plugging of a blood- vessel by a foreign body. Causes of thrombosis: (i) Changes in the walls of the blood-vessels, due to the pres- ence of infection or foreign bodies; (2) changes in the blood, whereby its tendency to coagulate is increased; (3) diminished rate of the blood flow, due to weak heart action or obstruction. Embolism is generally due to thrombi, but is also caused by fragments of vegetations or atheromatous or calcareous masses from the cardiac valves or the intima of the arteries; other causes are parasites, pieces of new growths, pigment granules, fluid fat, or air. Metastasis is the transfer of some pathological condition from one part of the body to another not immediately connected with it. Necrosis is the complete and permanent arrest of nutrition in a part; or local death of tissue. 2. Amyloid degeneration is a degenerative process in which the affected tissues have a whitish waxy appearance, due to the presence of a colorless, firm, translucent and lardaceous substance. With iodine it gives a blue stain. It generally occurs in : Liver, kidneys, spleen, lymphatic glands, intestines. 3. Parenchymatous inflammation is the name occasionally given to an inflammatory process when it attacks the active cells and tissues of an organ; as in parenchymatous ne- phritis, where the renal epithelium is affected. 4. The tubercle bacillus is rod shaped, is from 1% to $y 2 mikrons in length, and about one-third to one-half a mikron in breadth, is a strict parasite, is not motile, and has no flagella ; it has no spores, is non-liquefying, non-chromo- genic, erobic, and acid-resisting. A tubercle is a small nodule, found in the lungs or other organs in cases of tuberculosis, but also found in other diseased conditions. It consists of three layers, the outer one consisting of lymphoid cells, the middle one of epitheloid cells, and the inner one of giant cells. These layers are squeezed or compressed into a firm mass, which may caseate or un- dergo other pathological processes. There is no blood supply to a tubercle. 5. See French's "Practice of Medicine" (1907), page 154; or Osier's "Practice of Medicine" (1909), page 170. 6. See French's "Practice of Medicine" (1907), page 70; or Osier's "Practice of Medicine" (1909), page 65. 7. See French's "Practice of Medicine" (1907), page 902; or Osier's "Practice of Medicine" (1909), page 695. 8. Round or oval red patches, covered with adherent, silvery, or gray scales; these occur chiefly on the extensor surfaces of elbow, knee, and limbs ; also on scalp. There 165 MEDICAL RECORD. is more or less itching, and the condition is apt to be chronic. On removing the scales a red, punctate, bleed- ing surface is found. 9. See French's "Practice of Medicine" (1907), page 1047; or Osier's "Practice of Medicine" (1909), page 887. 10. (1) Diminution in number; (2) relative increase in amount of hemoglobin; (3) poikilocytosis ; (4) some are nucleated; (5) variation in size. DIAGNOSIS. 1. The tuberculin test consists in giving a hypodermic dose of 1 mg. of the fluid; if no reaction occurs in twenty-four hours, a dose of 2 mg. is given; if, again, there is no reaction in twenty-four hours, a dose of 3 rng. is given. The maximum dose is 10 mg. Its use is to aid in the diagnosis of tuberculosis. Results: It is said to be valuable; but some say it should never be used. 2. Pain in epigastrium, which is sudden and severe; vomiting; collapse; swelling and tenderness over epigas- trium ; and slight fever. 3. In cholecystitis are : Pain in and tenderness over gall- bladder; muscular rigidity; fever, rapid pulse, vomiting. In cholangitis the symptoms are much the same, but the pain is very much more severe, and radiates to right shoul- der; the fever is also less. 4. Neprolithiasis is characterized by: Renal colic, with pain radiating to testicle; hematuria; tenderness over af- fected kidney; jr-ray may show the calculus. This condi- tion is not likely to be mistaken for the two forms of nephritis. In chronic parenchymatous nephritis: The arine is slightly diminished, turbid, has abundance of albu- min, generally some blood, abundance of sediment, blood corpuscles, casts (especially fatty), diminished urea; may be cardiac hypertrophy; marked dropsy, and often uremia. In chronic interstitial nephritis: The urine is increased in quantity, pale, clear, of low specific gravity, little or no albumin, scanty sediment, few casts, diminished urea; the heart is hypertrophied, sometimes considerably; dropsy often absent till heart fails ; uremia frequent. 5. In secondary anemia: (1) A diminution in the num- ber of red corpuscles ; (2) a diminution in the amount of hemoglobin, perhaps greater than that of the red cor- puscles; (3) poikilocytosis, and variations in the size of the red corpuscles; (4) the presence of a few nucleated red corpuscles; (5) a moderate leucocytosis. In pernicious anemia: (1) A diminution in the number of red cor- puscles; (2) a relative increase in the amount of hemo- globin; (3) poikilocytosis; (4) the presence of nucleated red cells; (5) variation in the size of the red cells; (6) the leucocytes may be diminished. 166 MEDICAL RECORD. 6. (i) Tuberculosis. For description of bacillus, see above, Pathology, Question 4. For staining (in sputum) : See French's "Practice of Medicine" (1907). page 1216. (2) Gonorrhea. The Gonococcus is a diplococcus with a special predilection for the mucous membrane of the ureth- ra; it is sometimes found on the conjunctiva. The ap- pearance is that of two coffee beans; the gonococcus is found in the pus cells, stains with ordinary anilin dyes, but not by Gram's method. It is erobic, and can be cultivated on human blood serum; it will not grow on gelatin, agar, bouillon, or potato. (3) Diphtheria. The Klebs-Loeffler bacilli are from 2 to 6 mikrons in length and from 0.2 to 1.0 mikron in breadth; are slightly curved, and often have clubbed and rounded ends ; occur either singly or in pairs, or in irregular groups, but do not form chains; they have no flagella, are non-motile, and erobic; they are noted for their pleomorphism ; they do not stain uniformly, but stain well by Gram's method and very beautifully with Loeffler's alkaline-methylene blue. 7. The symptoms and physical signs of lobar pneumonia and acute pneumonic phthisis may be the same for the first eight or ten days; at this period the fever in pneumonia drops by crisis ; whereas in phthisis the fever continues for some time longer and the patient gets worse; the sputum contains tubercle bacilli and elastic fibers, and instead of retaining the rusty color it becomes purulent and greenish. In pneumonia, the breathing is very rapid, the pulse- respiration rate is disturbed, the fever is usually high, and runs a regular course, crepitant rales are heard at first, then signs of consolidation follow, and crepitant rales again succeed. In phthisis, the breathing is hurried and there is dyspnea, the fever is often high, but does not run a regular course, at first the signs are those of bronchitis, followed by consolidation, a softening, or excavation in different parts of the lungs ; sometimes there is nothing to be heard but scattered rales. 8. (1) A systolic murmur, soft and blowing, heard best at the apex, and transmitted to the left axilla and toward the angle of the left scapula, indicates mitral regurgitation. (2) A presystolic murmur, harsh and rough, heard best very near the apex, and not transmitted, denotes mitral stenosis. (3) A diastolic murmur, soft, heard best in the second right intercostal space, and transmitted down the sternum or toward the apex, denotes aortic regurgitation. (4) A systolic murmur, harsh, heard best in the second right intercostal space, and transmitted into the carotids, denotes aortic stenosis. (5) A systolic murmur, heard best over the lower end of the sternum, denotes tricuspid re- gurgitation. (6) A presystolic murmur, heard best over the ensiform cartilage, and not transmitted, denotes tricuspid 167 MEDICAL RECORD. stenosis. (7) A diastolic murmur, heard best in the second left intercostal space, denotes pulmonary regurgitation. (8) A systolic murmur, heard best in the second left intercostal space, and not transmitted to the large vessels of the neck, denotes pulmonary stenosis. (9) A murmur, usually sys- tolic, soft, and blowing, heard best over the pulmonic area, associated with evidences of chlorosis or anemia, and af- fected by the position of the patient, is a hemic or func- tional murmur, and denotes as a rule an impoverished con- dition of the blood. 9. Cerebral vomiting is projectile in character, and is ac- companied by little or no nausea, is continuous even after stomach is emptied; there is no salivation, no tenderness over liver or stomach. Gastric vomiting relieves the previ- ous nausea, and returns on ingestion of food; salivation is present, also tenderness over liver and stomach. 10. (a) Hutchinson's teeth are notched and stunted in permanent dentition; found in hereditary syphilis. (b) Babinski's sign: When the sole of the foot is tickled,, the toes (particularly the great toe) are over-extended, and separated from one another. (In primary lateral sclerosis.) (c) Koplik's spots are small red spots with a bluish cen- tral area, found on the buccal mucous membrane, in measles. (d) In Cheyne-Stokes respiration the respirations gradu- ally increase in volume and rapidity until they reach a climax, when they gradually subside, and finally cease for from ten to forty seconds, when the same cycle begins again. "In the majority of instances it is associated with apoplexy (toward the end), chronic nephritis (uremia), tumor of the brain, tuberculous meningitis, or degeneration of the heart muscle. Less frequently it is observed as a re- sult of cardiac valvular defects and consequent embolism, diabetes, and certain acute diseases, notably typhoid, pneu- monia, pertussis, cerebrospinal fever, scarlet fever, and septicemic conditions. " — (Butler's Diagnosis of Internal Medicine.) THEORY AND PRACTICE. 1. By wet nurse; by milk of cow or goat; by whole milk and its dilutions ; by cream-milk mixture ; by top-milk mixture; by cream-whey modifications; by milk modified with cereal decoctions or dextrinized gruels; by diluted condensed milk ; by "laboratory milk," which may be gravi- ty-separated or centrifuged; by peptonized milk; or by any of the numerous advertised substitutes. 2. See French's "Practice of Medicine" (1907), page 707; or Osier's "Practice of Medicine" (1909), page 434. 3. "Serum therapy depends upon the fundamental fact that a group of body cells — for example, those of the cen- 168 MEDICAL RECORD. tral nervous system — have a way of rising to the emer- gency when compelled to defend themselves against a group of foreign cells {e.g. tetanus bacilli) and of producing in excess substances antagonistic to such foreign cells or to their products. Such an antagonism is known as immunity. To be immune against a given cell is to possess the power of poisoning or dissolving that cell. This is known as antibacterial immunity. When the body is attacked, not by cell groups but by cellular products, such as toxins, another type of immunity is produced by virtue of which the blood of the immunized individual is able to neutralize and render inert the toxin molecules." — {Reference Handbook of the Medical Sciences.) Diseases in which it has been success- fully employed are : Diphtheria, tetanus, snake-bites, and rabies. a. See French's "Practice of Medicine" (1907), page 771 ; or Osier's "Practice of Medicine" (1909), page 508. 5. See French's "Practice of Medicine" (1907), page 65; or Osier's "Practice of Medicine" (1909), page 57. 6. See French's "Practice of Medicine" (1907), page 216; or Osier's "Practice of Medicine" (1909), page 282. 7. See French's "Practice of Medicine" (1907), page 1046; or Osier's "Practice of Medicine" (1909), page 886. 8. See French's "Practice of Medicine" (1907), page 139; or Osier's "Practice of Medicine" (1909), page 157. 9. See French's "Practice of Medicine" (1907), page 656; or Osier's "Practice of Medicine" (1909), page 606. 10. See French's "Practice of Medicine" (1907), page 932; or Osier's "Practice of Medicine" (1909), page 426. OBSTETRICS. i. See Williams' "Obstetrics" (1909), page 576; or Hirst's "Obstetrics" (1909), page 116. 2. See Williams' "Obstetrics" (1909), page 254; or Hirst's "Obstetrics" (1909), page 395. 3. Presumptive signs of pregnancy: (1) Progressive en- largement of the uterus; (2) Hegar's sign; (3) Braxton Hick's sign; (4) uterine murmur; (5) cessation of men- struation; (6) changes in the breasts; (7) discoloration of the vagina and cervix; (8) pigmentation and striae; (9) morning sickness. Positive signs of pregnancy: (1) Hear- ing the fetal heart sound; (2) active movements of the fetus; (3) ballottement; (4) outlining the fetus in whole or part by palpation; and (5) the umbilical or funic souffle. 4. See Williams' "Obstetrics" (1909), page 815; or Hirst's "Obstetrics" (1909), page 577. 5. See Williams' "Obstetrics" (1909), page 617; or Hirst's "Obstetrics" (1909), page 279. 6. See Williams' "Obstetrics" (1909), page 647; or Hirst's "Obstetrics" (1909), page 304. 169 MEDICAL RECORD. 7. (a) The indications for podalic version are: (1) In transverse presentations; (2) in placenta prsevia; (3) in malpresentations of the head; (4) in simple flattened pel- vis, and in minor degrees of pelvic contraction; (5) in pro- lapsed funis; (6) in sudden death of the mother; and (7) in any case where speedy delivery is imperative, (b) The absolute indications for cesarean section are: Extreme pelvic contraction or deformity in which delivery by for- ceps or version or symphyseotomy is impossible, and in which craniotomy is either impossible or would be more dangerous to the mother; the presence of extreme atresia of the vagina; rupture of the uterus; sudden maternal death, (c) Indications for the use of forceps are: "1. Forces at fault: Inertia uteri in the presence of conditions likely to jeopardize the interests of mother or child, (a) Impending exhaustion; (b) arrest of head, from feeble pains. 2. Passages at fault: Moderate narrowing, 3% to 334 inches, true conjugate; moderate obstruction in the soft parts. 3. Passenger at fault: A. Dystocia due to (a) oc- cipito-posterior, (b) mento-anterior face, (c) breech ar- rested in cavity. B. Evidence of fetal exhaustion (pulse above 160 or below 100 per minute.) 4. Accidental compli- cations: Hemorrhage; prolapsus funis; eclampsia. All acute or chronic diseases or complications in which imme- diate delivery is required in the interest of mother or child, or both." (From Jewett's Practice of Obstetrics.) 8. The head should be delivered promptly to avert the chance of the child being asphyxiated. 9. Phlegmasia alba dolens is a form of manifestation of puerperal sepsis in which there is a thrombosis of the iliac or femoral vein. Sometimes it occurs after a uterine phle- bitis, in which clots are carried from the uterine sinuses to the hypogastric veins, where they cause obstruction to the blood flow in the crural veins. The trouble may also begin as a crural phlebitis. It is thus due either to cellulitis or to thrombosis. It usually appears about the third or fourth week of the puerperium. 10. See Williams' "Obstetrics" (1909), page 824; or Hirst's "Obstetrics" (1909), pages 614 and 616. GYNECOLOGY. 1. Acute pelvic peritonitis. Etiology : Infection. Symp- toms: Intense and diffuse abdominal pain, tenderness, and distention; vomiting, constipation, elevation of the temper- ature (i03°-i04° F.), small, hard, rapid, and wiry pulse (120-140), and increased respiration (30-40) of a painful character are also present. The dorsal decubitus with the legs ancl thighs drawn up is assumed. The duration is from six to nine days and the prognosis is unfavorable. The treatment consists in rest in bed, the administration of 170 MEDICAL RECORD. opium or one of its alkaloids, and the application of hot or cold fomentations or turpentine stupes to the abdo- men. If the affection is due to septic infection a saturated solution of magnesium sulphate should be given. If sup- puration has occurred abdominal section should be per- formed with irrigation of the peritoneal cavity with normal salt solution (temperature i05°-no° F.) and the introduc- tion of drainage. — (Gould's and Pyle's Pocket Cyclopedia.) 2. Acute ovaritis is usually secondary to salpingitis, as in gonorrhea and puerperal sepsis, but may occur as a com- plication of the eruptive fevers. The symptoms are pain and tenderness in the ovarian region, nausea, vomiting, rise of temperature, and rapid pulse. The treatment consists in rest in bed, hot vaginal douches, free purgation, hot fo- mentations over the lower abdomen, and removal of the diseased structures if the symptoms grow worse and sup- puration ensues. ASCITES. i. Previous history of vis- ceral disease. 2. Enlargement compara- tively sudden. 3. Face puffy ; color waxy ; early anemia. 4. Patient on back, en- largement symmetrical; flat in front. 5. Sitting up, abdomen bulges below. 6. Navel prominent and thinned. 7. Fluctuation decidedly clear, diffuse throughout ab- domen, but avoids highest parts in all positions, and always has a hydrostatic level. 8. Intestines float on top of fluid ; hence percussion gives clear tympanitic note over the highest parts of abdominal cavity and dul- ness in lowest parts for all positions — i.e. areas of res- onance and dullness change with position. OVARIAN CYST. 1. No such history. 2. Gradual. 3. Facies ovariana. Ane- mia absent, or later. 4. Asymmetrical until tu- mor is quite large; promi- nent in front. 5. No appreciable change. 6. Navel usually un- changed. 7. Less clear; limited to cyst; not modified by change of position. No hy drostatic level. 8. No change in areas of dulness and resonance with change of position. Dulness over cyst. Clear resonant note in all parts beyond cyst limits, i.e. in flanks and toward the diaphragm. 171 MEDICAL RECORD. ASCITES. 9. Vaginal touch detects fluctuation, bulging into va- gina. 10. Uterus in prolapsed location, but position un- changed. Size and mobility unchanged. 11. Hydragogues and diu- retics temporarily remove the fluid. m 12. Fluid light straw color and thin. Coagulates spon- taneously. OVARIAN CYST. 9. Vaginal fluctuation less clear or absent. 10. Uterus displaced for- ward or backward, or later- ally by pressure of cyst. 11. Medicines have no ef- fect. 12. Fluid light or dark and of varying consistency; albuminous, but does not co- agulate spontaneously; may ^ contain colloid matter. — (From Dudley's Gynecology.) 4. Membranous dysmenorrhea. Symptoms: Severe pain at the beginning of the menstrual period, which increases till the expulsion of a membrane, which may come away whole or in several pieces. After this the pain usually ceases until the next period. Treatment: Curettage, which may have to be repeated (perhaps more than once) before a cure is effected. 5. Pelvic hematocele is an accumulation of blood in the pelvis due to rupture of a blood-vessel ; it is generally due to rupture of a tubal pregnancy, or to a tubal abortion. Symptoms: Pain which is sudden and severe, over ab- domen and pelvis; nausea, cold perspiration, cold extrem- ities pulse rapid and weak, pinched features, and shock. 6. Abscess of valvo-vaginal cland. Etiology: Gonor- rhea, or suppuration following cellulitis. Symptoms: The same as abscess anywhere else (redness, swelling, heat, pain, and sometimes fever and fluctuation). Treatment: Excision, or incision and drainage. 7. Symptoms of salpingitis: Pain or discomfort, made worse by pressure, examination, or defecation ; or colicky pains over the tube; dysmenorrhea; increased menstrual fjow; tabes are found to be dilated and swollen. Varieties: Hematosalpinx, when tubes are distended with blood; Pyosalpinx, when they contain pus ; Hydrosalpinx, when they contain serous fluid or exudate. 8. Urethral caruncle is a small red fleshy growth gen- erally situated on the posterior part of the meatus of the urethra. There are local pain and tenderness, which may be excessive; a burning sensation is experienced on urina- tion ; it may bleed. The proper treatment is to excise it or destroy it with the thermocautery. 172 MEDICAL RECORD. 9. Rectovaginal fistula. Symptoms: Flatus and feces are passed by the vagina. Digital or speculum examina- tion may show the fistula, and if milk is injected into the rectum, it will be noticed in the vagina. Vaginitis and vulvitis are present. Treatment: A plastic operation is necessary. The edges of the fistula are denuded and then approximated with sutures, the same as for vesicovaginal fistula. 10. Gonorrheal vaginitis. Symptoms: Pain and burn- ing in the vulva; pain and burning on micturition; dys- pareunia ; yellowish or greenish discharge, in which the gonococcus can be found; the vagina is hot, red, swollen, and tender. Treatment: Rest in bed, salines, mild unirri- tating diet, bathing of external genitals, copious vaginal douches of bichloride of mercury 1 :2000 three or four times a day; later, the vagina may be swabbed daily with a solution of nitrate of silver 1 to 5 per cent, or with a solution of potassium permanganate 1 per cent. Complica- tions: Cystitis, urethritis vulvitis, endometritis, salpingitis septic peritonitis, sterility, condylomata of vulva, abscess of Bartholin's glands. SURGERY. 1. Asepsis means freedom from germs. Antiseptics: Heat, bichloride of mercury, carbolic acid, iodoform, tormalin, formaldehyde, zinc chloride, albuminum acetate, potassium permanganate, hydrogen dioxide, creolin. 2. Suture. Materials: (1) Silkworm gut, used only on surfaces, from which it may subsequently be removed. (2) Silk, used in abdominal surgery, for suturing intestines and tying pedicles. (3) Catgut, used for buried sutures. (4) Kangaroo tendon, used for bone, and as an absorbable suture which will last a long time. (5) Silver wire, used for bone. 3. See Da Costa's "Surgery" (1908), pages 70 and 245. 4. Paronychia: Free and early incision, drainage, anti- septic dressings, tonics, and stimulants ; the nail may or may not have to be removed. Hordeolum: Hot com- presses, evacuate pus as soon as a yellow spot is seen, correct errors of refraction, look after general health. Empyema: Aspiration, drainage, irrigation, resection of ribs (Estlander's operation) or resection of chest wall (Schede's operation). 5. For diagnosis of stones in the gall-bladder see above, Diagnosis, Question 3. Stone in the urinary bladder may be diagnosed by: Increased frequency of micturition; pain at end of urination, chiefly felt at the end of the penis or in the neck of the bladder ; the urine may contain pus, mucous, or blood; a "click" can be obtained by using a 173 MEDICAL RECORD. searcher or sound; examination by the cystoscope may reveal the presence of the stone. 6. See Rose and Carless' "Surgery" (1908), pages 1044, J2j, and 1115; or Da Costa's "Surgery" (1908), page 858. 7. See Rose and Carless' "Surgery" (1908), pages 975 and 980; or Da Costa's "Surgery" (1908), page 868. 8. See Rose and Carless' "Surgery" (1908), page 408; or Da Costa's "Surgery" (1908), page 1060. Actinomycosis: Treatment consists in free local excision; or incision with erosion and cauterization ; slit up sinuses ; drain pus cavi- ties ; give large doses of potassium iodide ; tonics, stimu- lants, and best hygienic conditions are indicated. 9. The surgical complications of typhoid fever are : Gan- grene; arthritis; abscesses and furuncles; otitis media; hemorrhage from stomach; intestinal perforation; infec- tion of the gall-bladder; perforation of the gall-bladder; orchitis, epididymitis ; parotitis ; cerebral, laryngeal, thyroid, and thoracic troubles. 10. Appendic ostomy consists in suturing the tip of the appendix to the abdominal wall, and then by opening the appendix at the tip access is gained to the cecum for the purpose of irrigating the large intestine. Dactylitis is in- flammation of a finger or toe. Osteomyelitis is inflamma- tion of the marrow of a bone (either with or without involvement of the bone). Dubois' abscess is an abscess of the thymus gland, found in congenital syphilis. Hystero- trachelorrhaphy is a plastic operation for the repair of a lacerated cervix uteri. HYGIENE. 1. Constituents of soil: Silica, aluminum, lime, magne- sium, phosphorus, sulphur, iron, manganese, chlorine, so- dium, potassium, oxygen, nitrogen. Physical properties of soil: Porosity, permeability, capacity to receive water and to contain water, heat, color, compactness, moisture, capac- ity for air and gases. 2. Tilth is the superficial layer of soil which is the re- sult of the disintegration of rocks and the decay of animal and vegetable life; or that part of the soil which is moist- ened by the rain, warmed by the sun, permeated by the atmosphere, in which plants extend their roots and gather their soil food. Marl is a mixture of clay, sand, and amor- phous calcium carbonate. Loam is a mixture of sand, clay, and humus. Humus is the entire product of vegetable de- composition in the various intermediate stages of the process. Peat is the result of the incomplete decay of vegetable matter under water, and is compact and fibrous. Muck is similar to peat, but is less compact, not fibrous, and when dry is easily reduced to powder. Humus will 174 MEDICAL RECORD. retain the greatest amount of water; and peat is probably the most inimical to pathogenic organisms. 3. The average depth to which the soil is self-purifying is about three feet. The dwellers on the soil retard the process by allowing organic filth and moisture to accumu- late. 4. The sources and varieties of water have been classified thus : Wholesome 1. Spring water , na i afa h1e 2. Deep-well water... ^ eI > P alatable - 3. Upland surface water [-moderately palatable. (4. Stored rain water.] Suspicious. A 5. Surface water from cultivated^ I land (6. River water, to which sewage Ipalatable. Dangerous . . i gains access I [7. Shallow- well water J 5. A well may be polluted by a cesspool on a lower level, because it is not the location of the outlet of the well that determines the possibility of pollution ; but rather the rela- tive position of the cesspool and the point where the water enters the well. In those cases in which the cesspool is on higher ground than the well, the latter may be protected by the geological formation of the ground, such as the presence of a ledge of rock. 6. Ordinary filter beds for the purification of water are tanks of varying size, shape, and construction; the walls may be vertical or sloping; upon the paved bottom are pipes to carry off the filtered water. Above these pipes are successive layers of coarse gravel, fine gravel, coarse sand, and at the top fine sand about four feet deep. Through these layers the water passes. The fundamental principle of Dib din's bacteria beds is based on "the idea that purification in a filter bed is not brought about wholly at the surface, but that the whole bulk of the filter is concerned therein, and experiments were made to determine the results of filling a bed and restraining the outflow for different periods, thus giving the organisms throughout the bed the same opportunity for action." (Harrington's Hygiene.) The fundamental principle of Cameron's septic tank sys- tem is that "the sewage is first led into a tank from which air and light are excluded. Digestive changes take place in the sewage within this tank as the result of an anaerobic bacterial action, which is favored by the darkness, the absence of air, and the perfect stillness at which the sewage is maintained. Under these circumstances much 175 MEDICAL RECORD. of the solid matter is rendered soluble and dissolved." — (Notter and Firth's Hygiene.) 7. We inspire microorganisms ; but, in health, we do not expire them. 8. For the support of human life, the air should contain nearly 21 per cent, of oxygen, about 78 per cent, of nitro- gen, about 0.04 per cent, of carbon dioxide. 9. The result of inhaling carbon monoxide is that the carbon monoxide forms a very stable compound with the hemoglobin of the blood, and the result is that the hemo- globin cannot carry oxygen, and therefore asphyxiation occurs. Less than 0.25 per cent, by volume in the air will cause poisoning; and but 1 per cent, is rapidly fatal to animal life. 10. ''The occupations which are of particular hygienic interest embrace those which involve exposure to : Air vitiated by respiration; irritating and poisonous gases and fumes ; irritating and poisonous dusts ; infective matter in dust; offensive gases and vapors; extremes of heat; damp- ness ; abnormal atmospheric pressure ; constrained attitude ; overexercise of parts of the body; sedentary life. Some occupations are conducted under such conditions that they may very properly be regarded as belonging to a number of these groups." — (Harrington's Hygiene.) STATE BOARD EXAMINATION QUESTIONS. Illinois State Board of Health. ANATOMY. i. What becomes of the umbilical vein of the fetus? 2. Where and from what do the colic arteries arise, and what are the distributions? 3. Describe the articulations of the tibia. 4. From where are the renal arteries derived and into what do the renal veins pass ? 5. Where does the trigeminus or fifth pair of cranial nerves arise and What are the branches? 6. W T hat bones compose the orbit of the eye? 7. Where and how do the cavities of the greater and lesser omenta connect? 8. In fracture of the neck of the radius, what muscle draws the upper fragment outward and what ligament limits the extent of the displacement? 9. What is the origin, insertion, nerve supply, and action of the semimembranosus muscle? 10. What are the principal venous trunks? What veins are without valves? 176 MEDICAL RECORD. PHYSIOLOGY. 1. What effect would rapid heart with aortic regurgita- tion have on general blood pressure? Give reasons in detail. 2. Name the different pulse waves usually recorded by the sphygmograph. 3. Explain difference between clonic and tonic contrac- tion as applied to muscle fiber. 4. Discuss the relation of the ovaries to menstruation. 5. What are proteids? How are they digested? 6. What are the functions of the saliva? What glands secrete it? 7. What kinds of food would you recommend in cases of obesity? NEUROLOGY. 1. Name three frequent causes of abscess of the brain. 2. Define and give the symptoms of congenital hydro- cephalus. 3. Give etiology, symptoms, and treatment of facial paralysis. MATERIA MEDICA AND THERAPEUTICS. ■I. Outline the general management of fevers, and ex- plain the physiological action of drugs which lower tem- perature. 2. Name four of the safest antipyretics, giving the dose and therapeutic indications. 3. Give the indications for use of diuretics. Name one of each of the three principal classes, and give the physi- ologic action of one of them. 4. Give the indications for the use of cardiac stimulants, and name three, with dose and mode of administration of each. /5~. Name three of the animal extracts used in medicine, giving doses and indications for use. §/ Give the indications for the use of alteratives. Name three and give doses. 7. What are the indications for the use of expectorants? Name three and give dose of each. 8. Give the physiological action of belladonna. 9. What are the uses of the following: Male fern, ergot, antipyrine, bismuth, sulphate of magnesia, carbonate of magnesia? 10. Give the physiological action of digitalis. CHEMISTRY. 1. Write the equation representing the action which takes place by treating potassium chlorate with sulphuric acid. 2. Of what does turpentine consist? 177 MEDICAL RECORD. 3. What is the general formula of the monobasic acids? 4. Complete the following equations: HgS04+2NaCl= 5. Give the formulae of the chlorate, bromate, iodate, and sulphate of sodium. ETIOLOGY AND HYGIENE. 1. What is the etiology of interstitial hepatitis? 2. What is the etiology of acute parenchymatous ne- phritis? Is only one or are both kidneys affected? 3. What is the etiology of Addison's disease (melasma suprarenale) ? 4. What are the main points to be observed in a general disinfection? 5. What is the advantage in adding a small amount of sulphate of aluminum to impure water? PATHOLOGY. i. Describe the lesions produced in the liver by syphilis. 2. Mention the conditions of the kidneys which may be brought about by tuberculosis. 3. Describe the modes of formation and appearances of typhoid and of tubercular ulcers of the intestines. 4. In what general respects do "anemia" and "progres- sive pernicious anemia" differ? 5. Describe the formation of an acute abscess. BACTERIOLOGY. 1. Describe methods of culture and staining of the bacil- lus of diphtheria. 2. Name the microorganisms most commonly found in connection with acute endocarditis. 3. What bacteria are associated with inflammation and suppuration ? 4. What special culture medium is required for the growth of the gonococcus? 5. Describe the specific organism of tetanus, and state its peculiar culture characteristics. PRACTICE. 1. Give the symptoms and treatment of chronic diarrhea. 2. Give the etiology, symptoms, diagnosis, complications, and treatment of chorea. 3. Give symptoms, dangers, diagnosis, and treatment of bronchial asthma. 4. Give diagnosis, complications, dangers, and treatment of chronic contracting nephritis. 5. Give diagnosis of acute endocarditis, differentiating from chronic, and outline fully the management and treat- ment. 6. Give the diagnosis and treatment of chronic gastritis. 178 MEDICAL RECORD. 7. Differentiate hemiplegia due to apoplexy from that due to thrombosis or embolism, and give the treatment and prognosis. 8. Give the etiology, symptoms, and treatment of myx- edema, and distinguish from cretinism. 9. Give the diagnosis and treatment of pleurisy with effusion. 10. Give treatment of insomnia. PHYSICAL DIAGNOSIS. 1. Give symptoms and physical signs of pericardial effu- sion. 2. Give symptoms and physical signs of hydrothorax. 3. Give symptoms and physical signs of pulmonary ab- scess. 4. Give symptoms and physical signs of aneurysm of the arch of the aorta. 5. Give symptoms and physical signs of cirrhosis of the liver (atrophic form). OPHTHALMOLOGY AND OTOLOGY. i. Give etiology, symptoms, and treatment of iritis. 2. Give etiology, symptoms, and treatment of corneal ulcer. 3. Outline your treatment in a* case of chronic otitis media (suppurative). PEDIATRICS. 1. Give etiology, symptoms, and treatment of enteroco- litis. 2. Give your treatment in a case of marasmus. SURGERY. 1. What are the dangers to the patient during and after thyroidectomy? 2. Differentiate appendicitis from distended gall bladder. 3. Define the following terms : Nephrolith, nephrolith- otomy, nephrorrhagia, and nephrorraphy. 4. Differentiate hip-joint disease from congenital dislo- cation of the hip. 5. Outline surgical treatment of varicocele. 6. Describe the varieties of fracture of the scapula, and give the treatment of each. 7. Xame the structures which are severed in an amputa- tion at the lower third of the leg. 8. Classify tumors and state in what tissues of the body each is found. 9. Outline proper surgical treatment of aneurysm of the brachial artery. 10. Xame the different varieties of wounds, and give treatment of each. 179 .„ MEDICAL RECORD. OBSTETRICS. i. Describe segmentation. Where and at what period does, it occur ? 2. Describe the changes occurring in the mucous mem- brane of the uterus during uterogestation. 3. Enumerate and classify the signs of pregnancy. 4. What are the mental disturbances that may occur during pregnancy? 5. Describe hour-glass contraction, and give treatment of same. 6. Describe an embryo at two months. 7. Enumerate the congenital malformations of the head and face of a child, and state at what period of uterogesta- tion the arrested development occurs. 8. In an ordinary accouchement, what precautions should be observed to prevent infection? 9. Under what conditions is obstetric anesthesia to be employed? What anesthetic do you prefer, and how should it be administered? 10. Discuss the indications for forceps delivery and the application and manipulation of forceps. GYNECOLOGY. 1. Differentiate a fibroid tumor from a pelvic inflamma- tory deposit. 2. Give methods of treatment of carcinoma of the uterus when a radical operation is not indicated. 3. Give the etiology, symptoms, and treatment of steno- sis of the cervix. 4. Give the causes and treatment of pelvic peritonitis. 5. Give the etiology, symptoms, and treatment of ante- flexion of the uterus. 6. Give the causes, diagnosis, and treatment of inversion of the uterus. LARYNGOLOGY AND RHINOLOGY. i. Name the causes and give the appearances of edema of the larynx. 2. Give the symptoms and results of adenoid vegetations if untreated. MEDICAL JURISPRUDENCE. 1. Describe rigor mortis, and mention some of the con- ditions which promote its early appearance. 2. Differentiate a burn inflicted before death from one made after death. 180 MEDICAL RECORD. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Illinois State Board of Health. anatomy. I. The umbilical vein of the fetus dwindles and becomes the round ligament of the liver. 2. ARISE FROM Ileo-colic, Right colic. . Middle colic Left colic.., Superior Mesenteric. Superior Mesenteric. Superior Mesenteric. Inferior Mesenteric. Descending colon. DISTRIBUTION. Ileum, cecum, ileo-ce- cal valve, vermiform appendix. Ascending colon. Transverse colon. 3. The Tibia articulates: Above, with the femur and fibula ; below, with the fibula and astragalus. 4. The renal arteries are derived from the abdominal aorta. The renal veins pass into the inferior vena cava. 5. Trigeminus, or fifth pair of cranial nerves. Origin: (1) Superficial, from the side of the pons varolii; (2) Deep (sensory roots) from the medulla and upper part of cord; (motor root) from floor of fourth ventricle and side of the aqueduct of Sylvius. Branches: (1) Ophthalmic, giving off the: Lacrymal, Frontal, and Nasal. (2) Superior Maxillary, giving off the : Meningeal, Orbital, Spheno-palatine, Posterior superior dental, Middle superior dental, Anterior superior dental, In- fraorbital, Palpebral, Nasal, and Labial. (3) Inferior Max- illary, giving off the : Recurrent, Internal pterygoid, Masse- teric, Deep temporal, Buccal, External pterygoid, Auriculo- temporal, Inferior dental, and Lingual. 6. The bones which enter into the formation of the orbit are : The frontal, -sphenoid, ethmoid, superior maxillary, malar, lacrymal, and palate. 7. The greater and lesser peritoneal cavities connect by means of the foramen of Winslow. 8. In fracture of the neck of the radius the upper frag- ment is drawn outward by the Supinator brevis ; the orbic- ular ligament limits the extent of the displacement. 9. Semimembranosus. Origin: Tuberosity of ischium. Insertion: Inner tuberosity of the tibia, posterior ligament of the knee, and popliteal fascia. Nerve supply: Great sciatic. Action: To flex the leg upon the thigh; then in- ward rotation; also extension of the thigh. 181 MEDICAL RECORD. io. See Cunningham's "Anatomy" (1909), page 870,; or Gray's "Anatomy" (1908), page 723. The veins without vcdves are : The venae cavas, hepatic veins, portal vein and its branches, renal, uterine, ovarian, pulmonary, cerebral, spinal, and umbilical veins. The sinuses of the skull and very small veins are also without valves. PHYSIOLOGY. 1. Rapid heart would tend to raise the general blood pressure; in aortic regurgitation the blood pressure would tend to be lowered. Hence in the combined condition sug- gested in the question the effect on the blood pressure would depend upon the relative effect of the two conditions. The one might neutralize the other and the blood pressure be unaltered; or, either might predominate, with corre- sponding effect on the blood pressure. 2. The pulse waves usually recorded by the sphygmo- graph are : Cataerotic, predicrotic or tidal, dicrotic or recoil, and postdicrotic. 3. In tonic muscular contraction the muscle remains for some time in a state of rigid contraction. In clonic con- traction the muscle alternately contracts and relaxes. 4. Relation of the ovaries to menstruation: "It appears to be clearly demonstrated that the phenomenon of men- struation is dependent upon a periodical activity in the ovaries. When the ovaries are completely removed men- struation ceases (artificial menopause), and the uterus undergoes atrophy. When the ovaries are congenitally lacking, or rudimentary, a condition of amenorrhea also exists. These facts and the connection of the ovaries with menstruation are further corroborated in a striking way by experiments upon transplantation or grafting of the ovary. This experiment has been performed upon lower animals (apes) as well as upon human beings. Removal of both ovaries is followed by a cessation of menstruation. Transplantation of an ovary under the skin serves to main- tain menstruation, but if subsequently removed this func- tion disappears. An ovary or a piece of an ovary trans- planted into the uterus itself or the broad ligament caused a return of the menstrual periods, which had ceased after surgical removal of the glands, or brought on free men- struation in conditions of amenorrhea or dysmenorrhea." — (Howell's Physiology.) 5. Proteid foods are foods containing proteids. They contain nitrogen, and have a composition similar to that of albumin ; other elements contained in them are carbon, hydrogen, oxygen, and sometimes sulphur. Proteids are digested (1) in the stomach, where the pepsin of the gastric juice splits them into proteoses and peptones; and (2) in 182 MEDICAL RECORD the small intestine, where they are similarly treated by the trypsin of the pancreatic juice. 6. The functions of the saliva are: (i) To moisten the mouth, (2) to assist in the sofution of the soluble portions of the food, and thus (3) to administer to the sense of taste; (4) to lubricate the bolus of food, and thus (5) to facilitate the acts of mastication and deglutition, and (6) to change starches into dextrin and sugar. Saliva is secreted by the parotid, submaxillary, and sublingual glands. 7. Foods recommended in case of obesity: Dry foods, with diminished carbohydrates. Ebstein's diet for obesity is as follows : "Breakfast consists of a cup of black tea, without sugar or milk, and two ounces of buttered toast. Dinner, which is given at noon, comprises a meat soup or broth; four to six ounces of boiled or roasted fat beef, with meat gravy, not thickened ; one or two fresh vege- tables in moderation, and for dessert, salads and fresh or dried fruits. He allows a little light wine and black tea, without milk or sugar. Supper includes tea as before, a soft-cooked egg, and a moderate allowance of fish, ham, or cold fat meat, an ounce of thin, buttered bread or toast, and fresh fruit.' , NEUROLOGY. 1. Three frequent causes of abscess of the brain: Micro- bic infection following (1) chronic inflammation of the middle or internal ear; (2) caries of ethmoid, nasal, or orbital bones ; (3) compound fracture of the skull, with direct infection from the wound. 2. Congenital hydrocephalus is an abnormal accumulation of fluid in the ventricles of the brain. Symptoms: The head is of great size and may obstruct delivery: convul- sions, drowsiness, separation of the cranial sutures, bulg- ing of the fontanels, thinning of the bones of the head, and fluctuation may all be present. The forehead is prominent ; the child looks wasted, the head is spherical, and the eyes seem prominent. 3. See French's "Practice of Medicine'' (1907). page 1008; or Osier's "Practice of Medicine" (1909), page 1019. MATERIA MEDICA AND THERAPEUTICS. I. The general management of fevers: Attack the cause when possible {e.g. quinine in malaria) ; diminish heat pro- duction ; increase heat loss (diaphoretics); diminish the amount of nitrogenous food; keep the bowels moderately open ; keep up the heart's strength with stimulants, when necessary, and treat complications as they arise. A large, well ventilated room, with absence of unnecessary furni- ture, and absolute cleanliness are also necessary. The following table (from Potter's Materia Medico) 183 MEDICAL RECORD. gives the chief temperature depressants, with their manner of action: Temperature depression may be done by five different actions working upon two principal lines, viz., by : '(i) diminishing tissue (a) Lessening heat production by * (b) Promoting heat loss by change. (2) reducing the cir- culation. r (3) dilating cutaneous ves- sels, thus increasing heat radiation. (4) promoting perspiration, its evaporation lower- ing the temperature. (5) abstracting heat from the body. The following list of antipyretics includes a few for each of the above-named actions, to which the numbers refer in each case, viz. : Quinine, 1. Aconite, 2. Antipyrin, 1, 4. Phenol, 1. Alcohol, 1, 3. Antimony, 2, 4. Salicin, 1. Nitrous ether, 3, 4. Cold bath, 5. Digitalis, 2. Acetanilid, 1, 4. Cold drinks, 5. Phenacetin, 1, 4. Wet-pack, 5. 2. (1) Cold water, generally, and in typhoid fever. (2) Quinine, especially in malaria, dose, 4 grains of the bisul- phate. (3) Aconite, dose, TT£viij of the tincture. Chiefly acute inflammatory conditions ; it is contraindicated in typhoid. (4) Wet pack, same as cold water. 3. Indications for the use of diuretics: (1) To remove excess of fluid from the tissues, as in dropsy; (2) to dilute the urine; (3) to promote the elimination of waste prod- ucts or poisonous material from the blood, and (4) to maintain the action of the kidneys. (1) Hydragogue diuretic: Digitalis. (2) Stimulant diur- etic: Juniper. (3) Refrigerant duretic: Potassium acetate. 4. Indications for cardiac stimulants : Vasomotor paresis, heart failure, collapse, shock, valvular heart disease, heart weakness. Three: (1) Ammonia, by inhalation, or 3j doses of aro- matic spirit of ammonia in water. (2) Alcohol, dose JiJ of whiskey or brandy in water. (3) Salt solution (nor- mal), injected subcutaneously or into the rectum. 5. Three animal extracts: (1) Desiccated thyroid glands, dose gr. iv; used in myxedema, goiter, arteriosclerosis, and sporadic cretinism. (2) Pepsin, dose gr. iy; used as an aid to gastric digestion, and for predigestion of proteid foods. (3) Pancreatin, dose gr. vij ; used as an aid in digestion, and for predigestion of food. ' 6. Indications for the use of alteratives: Conditions of 184 MEDICAL RECORD. faulty nutrition ; perversions of metabolism ; chronic dis- ease or poisoning; cachexias and dyscrasias. Three alteratives: Mercury, dose of calomel, gr. j ; arsenic, dose of Fowler's solution, TT^iij ; iodine, dose of Potassium iodide, gr. vijss. 7. Indications for expectorants: Catarrhal conditions of larynx, trachea, and bronchi. Ammonium chloride, gr. vij ; glycyrrhiza, gr. xxx; senega, 15 minims of the fluid ex- tract. 8. Physiological action of belladonna: Anodyne, mydri- atic, inhibits secretions, depressant of terminations of nerves, accelerates the heart beat, causes rise in blood pressure, but toxic doses cause the blood pressure to fall ; stimulates the respiratory center, but large doses depress the same ; it may cause vertigo, restlessness, excitement, delirium, or mania. 9. Malefem, for tape worm; ergot, to cause uterine con- tractions and to stop hemorrhage; antipyrine, as an anti- pyretic and analgesic; bismuth, in gastric irritability, vomit- ing, and as a dusting powder; sulphate of magnesium, as a saline cathartic; carbonate of magnesium, in acidity of stomach, sick headache, and as a laxative. 10. Digitalis is a gastrointestinal irritant; a cardiac stimu- lant and tonic, slows the rate of the heart, increases _ its force, prolongs diastole, contracts the blood-vessels, raises the blood pressure, and is a diuretic. CHEMISTRY. 1. KC10s + H 2 S0 4 =rKHS0 4 4-HC103. 2. Turpentine consists of a stearoptene (such as rosin or colophony) and an eleoptene (such as oil of turpentine). 3. There is no general formula for the monobasic acids. In organic chemistry the monobasic acids all have one COOH (carboxyl) group; the acetic series has the gen- eral formula, CnHon0 2 . 4. HgS0 4 + 2NaCl = HgCl 2 + Na^SO*. 5. The formula of Sodium chlorate is NaC10 3 ; of So- dium bromate, is NaBr0 3 ; of Sodium iodate, is NaI0 3 ; of Sodium sulphate, is NaaSCX. ETIOLOGY AND HYGIENE. i. The etiology of interstitial hepatitis: Alcohol, syphi- lis, obstruction of bile ducts, long continued malaria, stim- ulating and highly spiced food; infectious fevers, heart disease. It is most common in males of middle age. 2. The etiology of acute parenchymatous nephritis: Ex- posure to cold and wet, acute specific fevers (especially scarlet fever and endocarditis), irritating drugs (turpen- tine, cantharides, potassium chlorate), extensive burns, and pregnancy. Both kidneys are affected. 18; MEDICAL RECORD. 3. The etiology of Addison's disease: Tubercular lesions in the suprarenal bodies, strains and injuries to the back, blows upon the abdomen, hemorrhage into the suprarenal bodies. More common in men. 4. Disinfection of rooms and their contents: "Articles of little value should be burnt. Bedding, clothing, carpets, etc., should be disinfected by steam. Towels, napkins, and sheeting should be soaked in a 5 per cent, carbolic acid solution and then boiled. Woodwork, floors, and plain furniture should be washed with a chlorinated lime solu- tion (1 per cent.) or with a corrosive sublimate solution (1 15000). Finally, the room should be fumigated with for- maldehyde gas or with sulphur dioxide, preferably with the former." — (Stevens' Materia Medica, etc.) 5. The addition of the sulphate of aluminum tends to purify the water, if calcium carbonate is also present. Cal- cium sulphate is thus formed, and this, with aluminium hydrate, entangles floating particles and carries them to the bottom of the vessel. PATHOLOGY. 1. Lesions produced in the liver by syphilis: "In the early stage there are pale grayish nodules, varying in size from a pea to a marble. The larger present yellowish cen- ters at first, but later there is a pale yellowish, cheese-like nodule of irregular outline, surrounded by a fibrous zone, the outer edge of which loses itself in the lobular tissue, the lobules dwindling gradually in its grasp. This fibrous zone is never very broad; the cheesy center varies in con- sistence from: a gristle-like toughness to a pulpy softness ; it is sometimes mortar-like from cretaceous change. When numerous, the most extensive deformity of the liver is produced in the gradual healing of these gummata. On the surface there are deep, scar-like depressions, and the entire organ may be divided into a cluster of irregular masses, held together by fibrous tissue. " — (Osier's Practice of Medicine.) 2. The condition of the kidneys which may be brought about by tuberculosis: Tubercles first form in the medul- lary portion of the kidneys; these coalesce, then caseate and soften. Cavities are thus formed, separated from each other by fibrous tissue. Ultimately the whole substance of the kidney may be destroyed; the pus is discharged in the urine, causing tuberculous pyelitis, and later, perhaps, pyonephrosis. 3. In the typhoid ulcer (1) the main axis of the ulcer lies parallel with that of the intestine; (2) it lies opposite to the mesenteric attachment; (3) it has smooth floor and undermined edges; (4) it commonly leads to perforation. In tubercular ulcer (1) the long axis of the ulcer lies at 186 MEDICAL RECORD. right angles to that of the intestine ; (2) it is not neces- sarily situated opposite the mesenteric attachment; (3) its floor is not smooth nor are its edges undermined, but rather funnel-shaped and irregular ; (4) it is not apt to perforate, but it does not tend to heal, rather to spread. 4. Anemia is a general term, including a variety of con- ditions, and indicating that the blood is reduced either in quantity, in coloring matter, or in number of red cells. These conditions are often more or less associated. Progressive pernicious anemia is a definite disease, of unknown origin, in which the number of the red cells is greatly diminished, the red cells are also changed in size and shape, nucleated red cells are present, and the disease tends to a fatal termination. 5. See Rose and Carless' "Surgery" (1908), page 62; or Da Costa's "Surgery" (1908), page 132. BACTERIOLOGY. 1. Methods of culture: The bacillus of diphtheria grows upon all the ordinary culture media, and can be readily obtained in pure culture. Loeffler's blood serum, par- ticularly with the addition of a little glucose, is an ad- mirable medium for the rapid growth of this bacillus. The medium should be alkaline and not less than 20 C. Method of staining: It stains with any aqueous solu- tion of an anilin dye, and quite characteristically with Loeffler's alkaline methylene blue. Neisser's stain is also recognized. The bacilli also stain well by Gram's method. 2. The microorganisms most commonly found in con- nection with endocarditis are : Streptococcus pyogenes, Staphylococcus pyogenes aureus, Staphylococcus pyogenes albus, pneumococcus, gonococcus, Bacillus tuberculosis, Eberth's bacillus, Bacillus anthracis, Bacillus coli com- munis, and Micrococcus lanceolatus. 3. The bacteria associated with inflammation and sup- puration are : Staphylococcus pyogenes aureus, Staphylo- coccus pyogenes albus, Staphylococcus pyogenes citreus, Streptococcus pyogenes, pneumococcus, gonococcus, Bacil- lus coli communis, Bacillus pyocyaneus, typhoid bacillus, Micrococcus tetragenus. 4. The special culture medium required for the growth of the gonococcus is blood serum or ascitic or pleuritic fluid. 5. The bacillus of tetanus is characterized by its pecu- liar spore, formed at one end of the bacillus, and giving it the appearance of a pin ; it is purely anaerobic, and cannot be developed at all in the presence of oxygen. It generally comes from the soil, and is found in penetrating wounds. It appears in two forms, the spore-bearing form, as de- scribed above, and the vegetative form, which is a short 187 MEDICAL RECORD. bacillus with rounded ends, and which may occur singly or in pairs, or may form long filaments. It grows in gelatin stab cultures in the middle of the medium, and the colonies look something like a fir tree; its growth is slow, and a disagreeable odor is at the same time emitted. In bouillon, it grows near the bottom of the tube, and produces gases. PRACTICE. 1. See French's "Practice of Medicine" (1907), pages 775 and 778; or Osier's "Practice of Medicine" (1909), page 503. 2. See French's "Practice of Medicine" (1907), page 1 1 17; or Osier's "Practice of Medicine" (1909) page 1045. 3. See French's "Practice of Medicine" (1907), page 659; or Osier's "Practice of Medicine" (1909), page 610. 4. See French's "Practice of Medicine" (1907), page 904; or Osier's "Practice of Medicine" (1909), page 700. 5. See French's "Practice of Medicine" (1907), pages 571, 579, 582, 587, and 589; or Osier's "Practice of Medi- cine" (1909), pages 791, 799, 803, 807, and 809. 6. See French's "Practice of Medicine" (1907), page J2>7\ or Osier's "Practice of Medicine" (1909), page 462. 7. "Cerebral Hemorrhage occurs after the age of fifty- five, as a rule, with atheromatous arteries and an hyper- trophied heart. The onset is sudden, with coma, during exertion or excitement. The temperature falls in an hour, and then rises, sometimes to 106 . Gradual recovery of consciousness takes place in from three to five days, with permanent 'hemiplegia. "Cerebral embolism comes at any age, with heart disease or after childbirth. There is a sudden onset, without loss of consciousness or with slight mental confusion, or with rapid return to consciousness. The temperature does not fall, but may rise as high as 102 °. Improvement occurs within twenty-four hours to a marked degree, but after three or four days the symptoms return. Monoplegia, hemiplegia, or aphasia may remain. Jacksonian epilepsy may develop if the lesion is cortical, involving a special center. "Cerebral thrombosis occurs at any age, but chiefly in syphilitic persons and middle-aged men. There are usually premonitions. The onset is slower, without coma, but with dullness of the mind. The temperature does not fall, but may rise to ioo°. The paralysis is similar to that observed in embolism. "The diagnosis between these three conditions is hardly ever positive." — (-Caille's Differential Diagnosis.) 8. See French's "Practice of Medicine" (1907), pages 552, 553, and 554; or Osier's "Practice of Medicine" (1909)* pages 768 and 770. 188 MEDICAL RECORD. 9. See French's "Practice of Medicine" (1907), pages 691 and 697; or Osier's "Practice of Medicine" (1909), pages 645, 651, and 653. 10. Treatment of insomnia: Removal of the cause, if pos- sible; regulation of the diet; systematic exercise; mild salines; avoidance of tea, coffee, or tobacco may be indi- cated; mental rest, change of scene or occupation; tonics: and, last of all, hypnotics. "When the habit of sleeplessness has become well estab- lished it may require more than the removal of the cause to effect a complete cure. Simple measures, however, should always be tried first before resorting to hypnotics. The bedroom should be quiet, well ventilated, and of moderate temperature. When the feet are cold the blood should be diverted from the head by hot foot baths, which may be made more effective by the addition of mustard. Vigorous rubbing of the limbs is also useful. A glass of hot milk, a cup of bouillon, or a toddy just before retiring often acts favorably as a derivative. In some persons light reading for half an hour, in others a brisk walk will invite sleep. In neurasthenia, massage and the systematic use of the wet-pack are invaluable aids." — (Stevens' Materia Med- ka, etc.) PHYSICAL DIAGNOSIS. 1. Pericardial effusion: Area of cardiac dullness is in- creased, the heart sounds are muffled, other organs may be displaced, dyspnea is present, the apex beat may be displaced to the left, the pulse is feeble, precordial pain and palpitation are present, the precordium bulges. 2. Hydrothorax: Bilateral effusion, distended chest, vocal fremitus is absent, there is dullness on percussion, breath sounds and vocal resonance are absent or distant, neighboring organs may be displaced, dyspnea and cyano- sis are present, Skodaic resonance is obtained above the effusion. 3. Pulmonary abscess: Fever, sweats, chill, leucocytosis, dyspnea, cough, purulent sputum with lung tissue, cavern- ous breathing, pectoriloquy. 4. Aneurysm of arch of aorta: Palpitation, difference in radial pulses (sometimes), dysphagia, dyspnea, cough, change in voice, pressure on nerves may cause irritation or paralysis, edema, intense pain, murmur, there may be a swelling of expansile character and with a thrill, and tracheal tugging. 5. Atrophic cirrhosis of the liver: Ascites, hemorrhoids, hematemesis, anorexia, nausea, gastric congestion, vomit- ing, constipation, muddy skin, first enlargement, later con- traction of liver, jaundice is a late symptom, emaciation, pallor, enlarged spleen, distended veins on abdomen, caput medusae. 189 MEDICAL RECORD. OPHTHALMOLOGY AND OTOLOGY. ^ I. Iritis. Etiology: Syphilis, rheumatism, gonorrhea, gout, diabetes, leprosy, scrofula, tuberculosis, injury, trans- mission from the eye. Symptoms: Pain, photophobia, small pupil, ciliary congestion, discoloration of iris, exudate in anterior chamber. Treatment: Atropine, dionine, the application of leeches to the temples, hot fomentations, absolute rest in bed, protection from the light, light diet, purgatives, abstinence from alcohol, avoidance of all use of the eyes for near work, constitutional treatment vary- ing according to the etiology, paracentesis, and iridectomy. v 2. Corneal ulcer. Causes: Infectious, traumatism, for- eign bodies, extension of inflammation, and nutritional dis- turbances. Symptoms: It is detected by oblique illumina- tion, the ophthalmoscope, or convex lens, and by dropping fluorescin upon the cornea, the denuded area being colored green. Pain, photophobia, lacrimation, swelling of the lids and conjunctiva, and destruction of tissue are symptoms. Treatment: Remove the cause, atropine, eserine, protection of eye by smoked glasses or bandage, hot compresses, anti- septic lotions, cauterization, paracentesis of cornea, or Saemisch's operation. 3. Chronic otitis media (suppurative). Treatment: Cotton must never be worn in the discharging ear. The discharge must be mopped out, but if very thick and copious syringing by means of sterile water or sterile water containing salt (gr. 5-3 1 ) or carbolic acid (1:40) once or twice in twenty-four hours in bad cases is permis- sible. After mopping the ear 10 drops of an antiseptic solution may be instilled. Formalin solution (1:1000- 1:2000), carbolic acid solution (1:40), or, if granulations are present, absolute alcohol may be dropped in and allowed to remain for a few minutes, and then turned out into a towel. This treatment should be continued once or twice a day in very bad cases, and less often when the discharge decreases. If, after several months, improvement does not take place, removal of the ossicles under general anesthesia may be necessary. — (Gould and Pyle's Pocket Cyclopedia.) pediatrics. 1. See French's "Practice of Medicine ,, (1907), page 785; or Osier's "Practice of Medicine" (1909), page 508. 2. Treatment of marasmus: The diet must be carefully investigated and regulated. If the child is breast-fed, the milk must be examined as to its composition, and the health and mode of life of the mother inquired into. In bottle-fed babies absolute cleanliness of bottles, nipples, and milk pans must be insisted on. If diarrhea is marked, it may be necessary to stop the use of milk for a time. Whey and barley water or peptonized milk may be used 190 MEDICAL RECORD. instead. After the diet has been regulated a dose of castor oil or calomel and magnesia may be given to clear away- irritating substances. Or Gray powder and Dover's powder may be given. The child should be warmly clad, and should be taken in the open air as much as possible. Colon irrigations may be beneficial. SURGERY. i. The dangers of thyroidectomy are: Sudden death during the operation, suffocation, dyspnea, cardiac inhibi- tion; tetany or acute myxedema may follow. 2. In appendicitis: The pain is at first diffuse, but later becomes localized over the appendix in the right iliac fossa ; nausea, vomiting, and constipation may be present; tender- ness over the appendix and rigidity of the right rectus abdominis muscle are present; there is generally moderate fever. • In distended gall-bladder: The pain is more severe and sudden, and is in the region of the liver; it radiates to the right scapula and toward the umbilicus; chills and sweats are common ; also vomiting, and sometimes symptoms of collapse and jaundice; all the symptoms come on more suddenly. 3. Nephrolith is calculus of the kidney. Nephrolithotomy is an operation for the removal of calculus from the kidney. Nephrorrhagia is hemorrhage from or into the kidney. Nephrorrhaphy is the suturing of a floating kidney (to the posterior abdominal wall). 4. Hip- joint disease has the symptoms : Muscular spasm (stiffness of the joint, or limitation of its motion) ; lame- ness ; attitude of the limb standing, or walking, or lying (adduction and abduction of the limb), and shortening; atrophy; and swelling. Congenital dislocation: "This need not be mistaken for hip disease, as the clinical history of the former is of continued limp since the child commenced walking. The trochanter is above Nelaton's line. There are no symptoms of muscular stiffness or limitation of motion of the hip in congenital dislocation ; in fact, no symptoms of hip disease except the limp in gait. Patients with congenital dislocation, however, at times have slight attacks of syno- vitis of the hip due to the imperfect mechanism of the joint, but these symptoms subside after a short rest.'' — (Bradford and Lovett.) 5. See Rose and Carless' "Surgery" (1908), page 1270; or Da Costa's "Surgery" (1908), page 397. 6. See Rose and Carless' "Surgery" (1908), page 496; or Da Costa's "Surgery" (1908), page 485.^ 7. The structures severed in an amputation at the lower 191 MEDICAL RECORD. third of the leg are : Skin ; fascia ; muscles, Peroneus longus, Peroneus brevis, tendo Achillis, tendon of Plantaris, Tibialis anticus, Tibialis posticus, Extensor longus hallucis, Extensor communis digitorum, Flexor longus hallucis, Flexor longus digitorum ; Arteries, anterior tibial, posterior tibial, peroneal ; Veins, anterior tibial, posterior tibial, peroneal, external saphenous, internal saphenous; Nerves, anterior tibial, posterior tibial, musculocutaneous, internal saphenous; Bones, tibia and fistula; and interosseous mem- brane. 8. See Rose and Carless' " Surgery" (1908), page 188; or Da Costa's "Surgery" (1908), page 302. 9. See Rose and Carless' "Surgery" (1908), page 326; or Da Costa's "Surgery" (1908), page 408. 10. See Rose and Carless' "Surgery" (1908), page 231; or Da Costa's "Surgery" (1908), pages 239 and 244. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), page 96; or Hirst's "Obstetrics" (1909), page 78. 2. See Williams' "Obstetrics" (1909), page 120; or Hirst's "Obstetrics" (1909), page 144. 3. Positive signs of pregnancy: (1) Hearing the fetal heart sound; (2) active movement of the fetus; (3) bal- lottement; (4) outlining the fetus in whole or part by palpation; and (5) the umbilical or funic souffle. Doubtful signs of pregnancy: (1) Progressive enlarge- ment of the uterus; (2) Hegar's sign; (3) Braxton Hick's sign; (4) uterine murmur; (5) cessation of menstruation; (6) changes in the breasts; (7) discoloration of the vagina and cervix; (8) pigmentation and striae; (9) morning sickness. Subjective signs of pregnancy, in the order of their ap- pearance, are : Cessation of menstruation, morning sick- ness, increased frequency of urination, active fetal move- ments. Objective signs of pregnancy, in the order of their ap- pearance, are : Softening of the cervix, changes in the mammary glands, discoloration of the vulva and vagina, pulsation in the vaginal vault, Hegar's sign, active fetal movements, ballottement, palpation of the fetus, intermit- tent uterine contractions, hearing the fetal heartbeat, rate of growth of the uterine tumor. 4. The mental disturbances that may occur during preg- nancy are : Changes in temper and disposition, the moral sense may be elevated or lowered, delusions may be present. 5. See Williams' "Obstetrics" (1909), page 664. 6. See Williams' "Obstetrics" (1909), page 145; or Hirst's "Obstetrics" (1909), page 84. 7. Congenital malformations of head and face: Acranius, 192 xMEDICAL RECORD. hemicrania, exencephalus, craniorachischisis, cephalocele, hydrocephalus, iniencephalus, microcephalus, micrencepha- lus, porencephalus, cyclocephalus, synophthalmus, synotus arhinencephalus, cyclostomus, anophthalmia, microphthal- mus, aprosopus, hare lip, cleft palate, and other faciai clefts. 8. See Williams' "Obstetrics" (1909), page 308; or Hirst's "Obstetrics" (1909), page. 778. 9. See Williams' "Obstetrics" (1909), page 321; or Hirst's "Obstetrics" (1909), pages 329, 636, and 783. 10. Indications for the use of forceps are: "1. Forces at fault: Inertia uteri in the presence of conditions likely to jeopardize the interests of mother or child, (a) Impend- ing exhaustion; (b) arrest of head, from feeble pains. 2. Passages at fault: Moderate narrowing, 2% to 3I4 inches, true conjugate; moderate obstruction in the soft parts. 3. Passenger at fault: A. Dystocia due to (a) occipito-pos- terior, (b) mento-anterior face, (c) breech arrested in cavity. B. Evidence of fetal exhaustion (pulse above 160 or below 100 per minute). 4. Accidental complications: Hemorrhage; prolapsus funis; eclampsia. All acute or chronic diseases or complications in which immediate de- livery is required in the interest of mother or child, or both." — (From Jewett's Practice of Obstetrics.) Conditions necessary for the use of forceps are: (1) The rectum and bladder must be empty; (2) the os uteri must be fully dilated; (3) the membranes must be rup- tured; (4) the pelvis must be of sufficient size. GYNECOLOGY. 1. Fibroid tumors are characterized by: Hemorrhage, pain, discomfort, pressure and traction symptoms (piles, constipation, tenesmus, dysuria, frequent micturition, uter- ine displacement); a tumor can be felt; pain, backache, bearing down pains, leucorrhea, and dysmenorrhea are common. Pelvic inflammatory infiltrations, unlike fibroids, always give a history of pelvic inflammation, are very tender on pressure, immobile, and prone to disappear by resolution or to undergo suppuration. 2. See Rose and Carless' "Surgery" (1908), page 1287. 3. Stenosis of cervix. Etiology: It may be congenital, or occur after labor, or abortion; or be due to caustics or cautery; or to ulceration. Symptoms: Obstructive dys- menorrhea, sterility, cramps. A probe or sound meets with an obstruction. Treatment: Dilatation, and insertion of gauze or a glass stem. The cervix may be cut in four directions under proper aseptic precautions. 4. Acute pelvic peritonitis. Etiology: Infection. Symp- toms: Intense and diffuse abdominal pain, tenderness, and 193 MEDICAL RECORD. distention ; vomiting, constipation, elevation of the tem- perature (iO3°-i04° F.), small, hard, rapid, and wiry pulse (120-140), and increased respiration (30-40) of a painful character are also present The dorsal decubitus with the legs and thighs drawn up is assumed. The duration is from six to nine days, and the prognosis is unfavorable. The treatment consists in rest in bed, the administration of opium or one of its alkaloids, and the application of hot or cold fomentations or turpentine stupes to the abdomen. If the affection is due to septic infection a saturated solu- tion of magnesium sulphate should be given. If suppura- tion has occurred abdominal section should be performed, with irrigation of the peritoneal cavity with normal salt solution (temperature io5°-no° F.) and the introduction of drainage. — (Gould's and Pyle's Pocket Cyclopedia.) 5. Anteflexion of uterus. Etiology: Congenital, due to arrested development; acquired, due to inflammation of uterus or its surroundings (cellulitis or parametritis), con- stipation, subinvolution, tumor in anterior wall of uterus. Symptoms: Dysmenorrhea, sterility, and various reflex nervous phenomena (such as disturbances of the bladder, headache, backache, leucorrhea, and frequent urination). Treatment: Dilatation of the cervical canal or a plastic operation (division of the cervix). 6. Inversion of uterus. Etiology: Childbirth, and uter- ine tumors. Diagnosis: In the case of polypus, the body and fundus of the uterus are in their normal position in the abdomen, a sound can be passed into the uterus, the uterine and cervical canals are not obliterated, the polypus does not bleed easily, and is not particularly sensible to pain. The inverted uterus shows : Absence of body and fundus from. normal position, will not permit passage of a sound into uterine cavity, the uterine and cervical canals are absent, the inverted uterus tends to bleed easily, and is very sensible to pain. In prolapse the largest part of the tumor is above; the opening of the Fallopian tubes cannot be seen ; a sound can be passed into the uterine cavity. Treatment: Reposition; and see Williams' "Obstetrics" (1909), page 824; or Hirst's "Obstetrics" (1909), page 616. laryngology and rhinology. 1. Edema of the larynx. Causes: Wounds of neck or larynx, burns or scalds of larynx, quinsy, aneurysmi, whoop- ing cough, erysipelas, syphilis, tuberculosis, malignant dis- ease, inflammations, diphtheria, Bright's disease, pneumonia. Appearances: The epiglottis is swollen, and the affected mucous membrane is pale and semi-translucent. \ 2. Symptoms of adenoids: Mouth-breathing; snoring; open mouth ; a vacant, dull expression of the face ; modifi- 194 MEDICAL RECORD. cation of the voice (nasal twang), with inability to pro- nounce certain letters. Effects: Earache and other ear affections; mental de- ficiency; frequent attacks of coryza; nose-bleed; stunted growth; convulsions, laryngismus stridulus, and various other neuroses may also be noticed. MEDICAL JURISPRUDENCE. i. Rigor mortis is the condition of rigidity or contrac- tion into which the muscles of the body pass after death. It begins at a period varying from about fifteen minutes to about six hours. It usually begins in the muscles of the eye, neck, and jaw; then the muscles of the chest and upper extremity, and last of all those of the abdomen and lower extremity are affected. It passes off in the same order. It is said to be due to the coagulation of the muscle plasma. Conditions which promote the early appearance of rigor mortis: Deaths from exhaustion, or violence, or electricity; when the muscular system is fatigued. 2. In burns produced before death: There is usually a blister, with a bright, red base, and containing a serous fluid, which is albuminous; occasionally there will be no blister if there has been excessive shock; also there will be a red line of demarcation between the injured and the uninjured parts, and this, being a vital process, is only developed during life. In burns produced after death there is no true blister, no red base, and gas only is present in place of the serous fluid. STATE BOARD EXAMINATION QUESTIONS. Indiana State Board of Medical Examiners. ANATOMY. i. Give the structure of the gall-bladder and its sur- gical landmarks. 2. Give the origin and insertion of each of the follow- ing muscles of abdomen: Obliquus externus, obliquus in- ternus, transversalis. 3. Name each bony prominence of the elbow and give its relations to the joint. 4. Name the blood-vessels and nerves divided in an amputation of the forearm at the union of the lower and middle third. 5. Name the blood-vessels that constitute the portal venous system, and the organs from which each conveys the blood. 195 MEDICAL RECORD. 6. Give the periods for the eruption of the temporary teeth. 7. Give the branches of the subclavian artery and thy- roid axis. 8. Locate an incision for ligation of external carotid, and state what structures are encountered. 9. What muscles effect the displacement of the frag- ments in an oblique fracture from above, downward and backward, of the femur immediately above the condyles, and how? 10. Make a drawing showing the nine regions of the abdominal cavity with the name and contents of each. PHYSIOLOGY. 1. Mention the chief heat-producing tissues of the body in the order of their capacity, and state why these struc- tures evolve more heat than others. 2. Give your opinion of alcohol as a food, and state your reasons and authority for such opinion. 3. Define absorption, secretion, and excretion, and state through which anatomical structures each occurs with greatest activity. 4. What is the mechanical effect upon the circulation of the blood of inspiration, normal expiration, and violent expiration ? 5. What portion of the vascular system is most sus- ceptible or responsive to the vasomotor nervous influence, and why? 6. In what particular does the condition of the brain in coma differ from its condition in sleep? 7. Explain briefly the difference between emulsification and saponification of oil and fats in the process of di- gestion. MATERIA MEDICA AND THERAPEUTICS. i. Give derivation, physiological action, and indications for the therapeutic application of ergot. 2. Name three medicinal agents which increase diaph- oresis. 3. Name an antagonist to the physiological action of jaborandi. 4. Name three medicinal agents which are emetic in their action, and dose of each. 5. Give physiological action, dose, and therapeutic in- dication for tr. of gelsemium. 6. Name (a) a hydragogue oathartic and (b) a chola- gogue cathartic, and dose of each. 7. Name some therapeutic indications for mercury. 8. What effect has benzoin on urine? Name two prep- arations of the agent with dose of each. 196 MEDICAL RECORD. 9. Give derivation, therapeutic indications, and dose of apomorphine. 10. Write a prescription for acute articular rheumatism. CHEMISTRY. 1. Give antidote in case of poisoning by (a) arsenic, (b) corrosive sublimate, and (c) carbolic acid. 2. Give specific gravity of healthy urine and give test for (a) bile, (b) sugar, and (c) albumin. 3. What is potassium iodide and how prepared? 4. Name the bile salts. 5. Name the fluids of the body that are normally of acid reaction. PATHOLOGY AND BACTERIOLOGY. i. How would you determine whether a dog had rabies or not? 2. Give technique of determination of rabies in the dog. 3. Give technique of determination of an epithelioma. 4. What is the difference between a benign and ma- lignant growth? 5. What is meant by a metastatic growth? 6. Give morphology and method of culture of the diph- theria bacillus. 7. Give morphology and method of culture of the tu- bercle bacillus. 8. Give complete technique of determining a case of diphtheria. 9. How would you stain the tubercle bacillus? 10. What is meant by (a) pathology and (b) bacteri- ology ? PHYSICAL DIAGNOSIS. i. Give technique of diagnostic puncture and the evi- dence derived therefrom. 2. Define ataxia. How is ataxia of the upper extrem- ities tested? How is ataxia of the lower extremities tested? 3. Give discrimination between organic and functional murmurs. 4. Give technique of cardiac percussion. 5. What is the normal pulse rate ? What is the increase for each degree of temperature above normal? INTERNAL MEDICINE. 1. Give common cause, prevention, and treatment of summer diarrheas of infancy and childhood. 2. In auscultation of healthy lung, what sound is heard, and what is it called? 197 MEDICAL RECORD. 3. Name some diagnostic symptoms of secondary syph- ilis. 4. Name the cardinal symptoms of exophthalmic goiter. 5. Give differential diagnosis between renal colic and hepatic colic. 6. Name some of the causes of endocarditis. 7. What conditions predispose to cerebral hemorrhage? 8. Differentiate between cerebral vomiting and gastric vomiting. 9. By what routes and media does the exciting cause of typhoid fever gain entrance to the human organism? How may it be prevented? 10. Name some points of diagnostic value in chronic interstitial nephritis. OBSTETRICS. 1. State the cause of (a) deficient power of the uterine muscle, and (b) excessive power of the uterine muscle. Give proper management of each. 2. Define caput succedaneum, and give etiology. 3. Name four important signs of pregnancy at the third month. 4. Differentiate between pregnancy and fibroid of the uterus. 5. Under what conditions would you perform podalic version? Give technique of operation. 6. What changes occur in the circulation at birth? 7. Give the causes of cystocele and rectocele, and state the treatment which should be employed. 8. When should ergot be employed in obstetric practice? What are its contraindications? 9. Name the symptoms of puerperal sepsis. How would you prevent it? 10. What are the premonitory symptoms of puerperal convulsions? What treatment would you employ to pre- vent puerperal convulsions? GYNECOLOGY. 1. Define the (a) dorsal posture, (b) left lateral-prone posture, and (c) knee-chest posture. 2. Give causes, diagnosis, and treatment of endocervi- citis. 3. Give diagnosis and treatment of ectopic gestation. 4. Give causes, pathology, diagnosis, and treatment of salpingitis. 5. Give preparation of patient for an ordinary plastic operation. 6. Give causes and symptoms of urethrocele. Give differential diagnosis. 198 MEDICAL RECORD. SURGERY. 1. Give diagnostic points of fracture of base of skull. 2. Give diagnosis and treatment of appendicitis. 3. Describe a compound fracture and give treatment. 4. Give diagnosis and treatment of gallstones. 5. How many kinds of hernia are there ? 6. Through what channels is carcinoma disseminated? 7. What indications are to be followed to promote primary union of a wound? 8. Give signs, symptoms, and treatment of fracture of the clavicle. 9. Give indications for trephining in fracture of the skull. 10. Name five causes of swelling in inguinal region. PEDIATRICS. 1. Give sequelae that most frequently follow eruptive fevers occurring in childhood, and state cause and prog- nosis for same. 2. Give diagnosis, cause, and treatment for cholera in- fantum. NEUROLOGY. 1. Give symptoms of cerebral compression. 2. Give definition of dementia and state the more im- portant forms. 3. What are the diagnostic symptoms of multiple sclerosis ? LARYNGOLOGY AND RHINOLOGY. 1. Give treatment of nasal polypi. 2. Give etiology and treatment of hypertrophy of the tonsil. OPHTHALMOLOGY AND OTOLOGY. i. Give causes, diagnosis, and treatment of chronic glaucoma. 2. Give symptoms, diagnosis, and treatment of gonor- rheal conjunctivitis. 3. Give etiology, symptoms, and treatment of acute in- flammation of the middle ear. ETIOLOGY AND HYGIENE. i. Give cause and hygienic treatment of diphtheria. 2. What is most essential from a sanitary standpoint in plumbing a bath-room? 3. What method would you use in filtering a city water supply ? 4. How would you place a water-closet in relation to a farmhouse? 199 MEDICAL RECORD 5. Write an article not exceeding seventy-five words on the practical value of the operation of the Pure Food and Drug Act. MEDICAL JURISPRUDENCE. 1. Give signs of death by morphine. 2. Define (a) delusion, (b) illusion, and (c) hallucina- tion. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Indiana State Board of Medical Examiners. anatomy. 1. See Cunningham's "Anatomy" (1909), pages 11 19 and 1270; or Gray's "Anatomy" (1908), page 1350. 2. See Cunningham's "Anatomy" (1909), page 422; or Gray's "Anatomy" (1908), page 435. 3. The bony prominences at the elbow are: (1) the external condyle of the humerus, (2) the internal condyle of the humerus, and (3) the olecranon process of the ulna. If the forearm is extended, the internal condyle of the humerus, the tip of the olecranon, and the external condyle will all be found on the same transverse line. In extreme extension the tip of the olecranon is slightly above the level of the condyles. If the forearm is flexed to a right angle, the tip of the olecranon is immediately below the condyles. 4. In an amputation of the forearm at the union of the lower and middle thirds there will be divided: (1) Arteries: radial, ulnar, anterior and posterior interosseous. (2) Veins: radials, ulnars, interosseous, median, anterior and posterior ulnars. (3) Nerves: median, radial, ulnar, ante- rior and posterior interosseous, musculocutaneous and in- ternal cutaneous. 5. The blood-vessels that constitute the portal venous system, are: The (1) superior mesenteric vein, which conveys the blood from the small intestines, the cecum, and ascending and transverse colon; (2) splenic vein, which conveys the blood from the spleen; (3) inferior mesenteric vein, which conveys the blood from the descending colon, sigmoid flexure and rectum ; (4) gastric vein, which con- veys the blood from the stomach. 6. See Cunningham's "Anatomy" (1909), page 1028; or Gray's "Anatomy" (1908), page 1219. 7. Branches of subclavian artery: Vertebral, thyroid axis, internal mammary, and superior intercostal. Branches of thyroid axis: Inferior thyroid, suprascapular, and trans- versalis colli. 200 MEDICAL RECORD. 8. The line of incision for ligation of the external caro- tid artery is the upper part of a line drawn from the sternoclavicular articulation to a point midway between the angle of the jaw and the tip of the mastoid process. The portion above the level of the upper border of the thyroid cartilage represents the line of the external carotid. The structures en-countered 'are: The skin; superficial fas- cia with the external jugular vein and the great auricular nerve ; the platysma myoides, and the deep fascia ; the an- terior border of the sternomastoid; the hypoglossal nerve; facial, lingual, and superior thyroid veins. 9. In oblique fracture of the femur, immediately above the condyles : The lower fragment is tilted backward by the gastrocnemius and plantaris. The upper fragment is drawn inward by the pectineus and adductors ; and for- ward by the psoas and iliacus. 10. See Gray's "Anatomy" (1908). pages 1246 and 1244. • PHYSIOLOGY. 1. The chief heat-producing tissues of the body, are : (1) The muscles, during contraction (including the heart) ; (2) the secreting glands, especially the liver; (3) the brain, during mental activity. 2. "The exact value of alcohol as a food, broadly con- sidered, is uncertain. Recent experiments, carefully made on man, however, clearly show that when moderate amounts of alcohol are ingested, the alcohol is burned up in the body — i.e. oxidized like any non-nitrogenous food. The potential energy of the alcohol is transformed into kinetic energy, and consequently alcohol is to be considered as having some food value. It may, therefore, be classified with the non-nitrogenous foods. Further, as a non-nitro- genous food, alcohol may replace an isodynamic amount of fat or carbohydrate in the diet without change in the bal- ance of income and outgo. Alcohol serves to protect body protein and fat from oxidation; i.e. like a typical non-pro- teid food it diminishes the oxidation of tissue proteid by being itself oxidized. These facts, however, do not imply that alcohol is necessarily a desirable food or that it is physiologically economical. It is to be remembered that, prior to its oxidation in the body, alcohol may produce deleterious effects of various kinds, more than counter- balancing any gain which may result from its oxidation. It may likewise give rise to changes, either directly or indirectly, in the various metabolic processes of the body, which must of necessity influence more or less its value as a food. Alcohol has a direct and an indirect influence upon the secretion of gastric juice. In this direction it acts as a stimulant. It likewise stimulates the secretion 201 MEDICAL RECORD. of saliva." — (Chittenden in Reference Handbook of the Medical Sciences.) 3. Absorption is the process by which the products of digestion are taken up into the general circulation. It occurs with greatest activity in the villi of the small intestine. Secretion is the process by which certain organs (glands and membranes) separate from the blood certain constitu- ents which are further elaborated and serve some further office in the economy. It occurs with the greatest activity in the liver (unless the urine is considered as a secre- tion). Excretion is a similar process by which there are re- moved from the blood waste materials, and products of no further use to the body, and which if retained would be injurious. It occurs with greatest activity in the lungs and kidneys. 4. Inspiration causes the blood pressure to rise, and the heart to beat faster, but each beat is shallower. Expiration causes the blood pressure to fall and the heart to beat slower, but the beats are deeper and more dicrotic. 5. The portion of the vascular system most susceptible to the vasomotor nervous influence: The arterioles or small arteries. The reason: Because they contain relatively the greatest amount of muscular tissue. 6. In sleep, the brain is anemic; whereas in coma, the cerebral vessels are congested with venous blood. 7. Under the influence of the steapsin of the pancreatic juice, neutral fats combine with water; the result is a splitting up into glycerin and a free fatty acid. In saponification a similar reaction occurs, but the re- sulting products are glycerin and a soap. EmulsiUcation is a physical rather than a chemical proc- ess ; the fat is broken up into minute globules which are in a state of more or less permanent suspension. Soap solutions make the most permanent emulsions. MATERIA MEDICA AND THERAPEUTICS. i. Ergot. Derivation: The selerotium of the claviceps purpurea. Physiological action: Ergot stimulates and causes con- traction of involuntary muscle fibers, hence it is a vaso- constrictor, hemostatic, and oxytocic. It is also a cardiac sedative, it raises the blood pressure, it increases peristal- sis, and is an emmenagogue. Indications for the therapeutic application: To promote uterine contractions during third stage of labor; fibroids, menorrhagia, post-partum hemorrhage. Some forms of 202 MEDICAL RECORD. amenorrhea and dysmenorrhea, dysentery, arterial hemor- rhage, congestive headaches, laxity of sphincters, of blad- der or rectum, hemorrhoids, aneurysm, diabetes, urinary incontinence, direct paralysis of the sphincter vesicae, atonic spermatorrhea. 2. Three medicinal agents which increase diaphoresis: (i) Alcohol; (2) Dover's powder; (3) pilocarpus. 3. An antagonist to the physiological action of jabor- andi: Atropine. 4. Three emetics: (1) Apomorphine hydrochloride; dose, gr. 1/10 hypodermically. (2) Copper sulphate; dose, gr. iv to vj in water. (3) Zinc sulphate; dose, gr. x to xv in water. 5. Tincture of gelsemium. Physiological action: Cir- culatory, respiratory, and nervous depressant. Dose: 8 minims. Therapeutic Indications: Headache, migraine, asthma, whooping cough, nervous cough, spasmodic dysmenorrhea, torticollis, and other conditions depending upon localized muscular spasm. 6. (ia) A hydragogue cathartic : Elaterin, dose gr. 1/20 to 1/12. (b) A cholagogue cathartic: Podophyllum, dose gr. viij to xij. 7. Therapeutic indications for mercury: As an anti- septic; as an application to ulcers, sores, warts, chancroids, etc. ; as an antisyphilitic ; as a cathartic, a diuretic, and an absorbent. 8. Benzoin increases the acidity of the urine. Sodium benzoate; dose, gr. xv. Benzoic acid; dose, gr. vij. 9. Apomorphine is derived from morphine (by the ab- straction of one molecule of water). Therapeutic indications: To cause prompt vomiting, and as an expectorant (in bronchitis and pneumonia). Dose of apomorphine hydrochloride : gr. 1/30 as an ex- pectorant; and gr. 1/10 as an emetic. 10. For acute articular rheumatism: 5. Sodii salicylatis 3ijss Fluidextracti glycyrrhizae. Tincturae aurantii aa 3ijss. Aquae chloroformi q.s. ad. 3 vn J- Misce. Signa : Take two tablespoonfuls every four hours. chemistry. 1. The antidote to: (a) arsenic, is freshly prepared fer- ric hydroxide; (b) corrosive sublimate, is white of egg in moderate quantity, followed by an emetic; (c) carbolic acid, is sodium sulphate, or alcohol. 2. The specific gravity of healthy urine is about 1015 to 1025. 203 MEDICAL RECORD. (a) Test for bile: Put 3 c.c. HN0 3 in a test tube, add a piece of wood, and heat until the acid is yellow; cool. When cold, float some of the urine to be tested upon the surface of the acid. A green band is formed at the junc- tion of the liquids, which gradually rises, and is succeeded from below by blue, reddish-violet, and yellow. (b) Test for sugar: The urine should first be tested for albumin. If this be present, it should be removed by heating the urine to near the boiling point, and filtering from the coagulum. Fehling's test: Place in a test-tube a few c.c of the liquid prepared as stated below, and boil ; no reddish tinge should be observable, even after five minutes' repose. Add the liquid under examination gradually, and boil after eac^ addition. In the presence of sugar a yellow or red pre- cipitate is formed. In the presence of traces of glucose, only a small amount of precipitate is produced, which ad- heres to the glass, and is best seen when the blue liquid is poured out. [The reagent must be kept in two solutions, which are to be mixed immediately before use. Solution I consists of 34-653 gms. of crystallized CuS0 4 , dissolved in water to 500 c.c. ; and Solution II of 130 gms. of Rochelle salt dis- solved to 500 c.c. in NaHO solution of sp. gr. 1.12. When required for use equal volumes of the two solutions are mixed, and the mixture diluted with four volumes of water.] (c) Test for albumin: The urine must be perfectly clear. If not so, it is to be filtered, and, if this does not render it transparent, it is to be treated with a few drops of mag- nesia mixture, and again filtered. The reaction is then ob- served. If it be acid, the urine is simply heated to near the boiling point. If the urine be neutral or alkaline, it is rendered faintly acid by the addition of dilute acetic acid, and heated. If albumin be present, a coagulum is formed, varying in quantity from a faint cloudiness to entire solidification, according to the quantity of albumin present. The coagulum is not redissolved upon the addi- tion of HNO3. 3. Potassium iodide is a transparent, or milk-white, crystalline, solid; odorless, with a sharp salty taste. It is very soluble in water. It is prepared by saturating a solu- tion of potassium hydroxide with iodine, then evaporating, and calcining the resulting mixture of iodide and iodate with charcoal: 6KHO + 3I2 = KIO3 + 3H 2 + 5KI 4. The bile salts are: Sodium glycocholate and sodium taurocholate. 5. The fluids of the body that are normally of acid re- action, are : The urine, gastric juice, and sometimes sweat 204 MEDICAL RECORD. PATHOLOGY AND BACTERIOLOGY. i and 2. "In order to find out whether the dog has hydro- phobia the animal may either be put up and observed to see whether characteristic symptoms develop, or it may be immediately killed. In the latter case the brain and cord should be examined for the presence of the Negri bodies, and the intervertebral ganglia for the presence of round-cell infiltration which is often marked. Rabbits or guinea-pigs should also be inoculated under the dura. It is safer not to wait for the result of the examination, but to subject the person who is bitten to the Pasteur treatment in advance of this, unless it is improbable that the dog is mad. The examination consists in looking for the Negri bodies and in subdural inoculation of rabbits. If the cord of the dog can be obtained, the intervertebral ganglia will show round-cell infiltration. All other ganglia may also show this change. The plexiform and Gasserian ganglia are convenient for examination. Great care must be taken that the operator may not accidentally infect him- self." — (Williams' Bacteriology.) 3. See Rose and Carless' "Surgery" (1908), page 213. 4. Benign tumors are encapsulated, do not tend to in- filtrate the surrounding tissues, do not give rise to metas- tatic growths, do not tend to recur after removal, do not produce cachexia, and do not have a fatal tendency (ex- cept from their location). Malignant tumors are not encapsulated, tend to infiltrate the surrounding tissues, give rise to metastatic growths, have a tendency to recur after removal, give a cachexia, have a fatal tendency. 5. A metastatic growth is one that is set up in a part of the body not directlv continuous with the original growth. 6. The Klebs-Lceffier bacillus is a short rod, about three to six microns in length, and about a half to one micron in breadth ; the extremities may be rounded or clubbed. The bacilli are slightly curved, and may occur singly, in pairs, or in groups ; they are non-motile, have no flagella. are erobic, and contain granules which take on a deeper stain. The bacillus stains with the analine colors, by Gram's method, and with Loefrler's alkaline methylene-blue. Method? of culture: The bacillus of diphtheria grows uoon all the ordinary culture media, and can be readily obtained in pure ntilture. LoefBer's blood serum, particu- larly with the addition of a little glucose, is an admirable medium for the rapid growth of this bacillus. The medium should be alkaline and not less than 20 C. 7. The tubercle bacillus is rod shaped, is from 1^ to S J /2 microns in length, and about one-third to one-half a micron in breadth, is a strict parasite, is not motile, and has 205 MEDICAL RECORD. no flagella. It is slightly curved, does not form spores, is not liquefying, and nonchromogenic, is aerobic; it resists acids; it grows well on blood serum, glycerin agar-agar, glycerin and gelatin; stains well by Ehrlich's, Ziehl-Niel- sen's, or Gabbett's method; it is Gram-positive. 8. A sterile swab is rubbed over any visible membrane on the tonsils or throat, and is then immediately passed over the surface of the serum in a culture tube. The tube of culture, thus inoculated, is placed in an incubator at 37° C. for about twelve hours, when it is ready for examina- tion. A sterile platinum wire is inserted into the culture tube, and a number of colonies of a whitish color are re- moved by it and placed on a clean cover slip and smeared over its surface. The smear is allowed to dry, is passed two or three times through a flame to fix the bacteria, and is then covered for about five or six minutes with a Loef- fler's methylene-blue solution. The cover slip is then rinsed in clean water, dried, and mounted. The bacilli of diph- theria appear as short, thick rods with rounded ends ; irreg- ular forms are characteristic of this bacillus, and the stain- ing will appear pronounced in some parts of the bacilli and deficient in other parts. 9. The material must be recent, and, if sputum should be free from particles of food or other foreign matter ; se- lect a cheesy-looking nodule and smear it on a slide, mak- ing the smear as thin as possible. Then cover it with some carbolf uchsin, and let it steam over a small flame for about two minutes, care being taken that it does not boil. Wash it thoroughly in water and then decolorize by im- mersing it in a solution of any dilute mineral acid for about a minute. Then make a contrast stain with solution of Loeffler's methylene blue for about a minute; wash it again and examine with oil immersion lens. The tubercle bacilli will appear as thin red rods, while all other bacteria will appear blue. 10. Pathology is that branch of science which treats of disease; it includes the causes, nature, manifestations, structural changes, and results. Bacteriology is that branch of science which treats of bacteria. PHYSICAL DIAGNOSIS. 1. See Da Costa's "Surgery" (1908), pages 763 and 782. 2. Ataxia may be defined as lack of co-ordination in muscular movements, so that the performance of certain acts becomes difficult or impossible. To test ataxia of the upper extremities: The patient, with his eyes closed or bandaged, is asked to touch the tip of his nose or the lobe of his ear, first with one index finger, then with the other; or the tip of one finger with the tip of some other indicated finger. Or the patient may 206 MEDICAL RECORD. be asked to thread a needle. If these things are done successfully the co-ordination is good, and there is no ataxia. To test ataxia of the lower extremities: If the patient can walk, he may be asked to walk along a straight line, such as the crack between two boards of the floor, or along the border of the carpet. If he cannot walk, he should have his eyes covered, and be requested to touch the inner mal- leolus of one foot with the great toe of the other foot. Or the patient may be asked to stand with his heels together and his eyes closed and to notice whether he stands fairly steadily or sways about considerably. In the latter event there is ataxia. 3. Organic murmurs are due to stenosis or incompetency of one or more of the valves of the heart. Functional murmurs are not due to valvular disease. Organic murmurs may be systolic or diastolic; may be accompanied by marked dilatation or hypertrophy, and there will probably be a history of rheumatism or of some other disease capable of producing endocarditis. Whereas a murmur, usually systolic, soft, and blowing, heard best over the pulmonic area, associated with evidences of chloro- sis or anemia, and affected by the position of the patient, is a hemic or functional murmur, and denotes as a rule an impoverished condition of the blood. 4. Method of percussing the heart: "The patient should be recumbent. Commence by defining the area of deep cardiac dullness. . Use moderately strong percussion, and percuss towards the cardiac area. The note is at first pulmonary and gradually grows dull, until the limit of absolute cardiac dullness is reached. For ordinary clinical purposes it is only necessary to percuss in two directions — vertically, parallel to the left margin of the sternum, and transversely, at the level of the fourth rib. (1) Percuss vertically downwards in the left parasternal line, in order to avoid the dullness due to the aorta and pulmonary artery. Percussing downwards from the lower edge of the clavicle, and comparing rib with rib, and interspace with interspace, the full note of the lung becomes impaired at about the upper edge of the third rib. This is, then, the limit of relative or deep cardiac dullness in this situation. (2) Percuss transversely at the level of the fourth rib: To define the left border of the heart commence in the left axilla and, keeping the finger on which percussion is made parallel with the left border of the heart, percuss from left to right along the fourth rib. The left border is nor- mally found about % inch external to the apex beat, or from 2>V2 to 3^4 inches from the mid-sternal line, at the level of the fourth and fifth interspaces, and 3 inches from the mid-sternal line at the level of the fourth rib. To 207 MEDICAL RECORD. define the right border of the heart commence in the right anterior axillary line and percuss from right to left along the fourth rib. The right margin of deep dullness at that level is normally found in the right lateral sternal line, or one inch to the right of the mid-sternal line." — (Brown and Ritchie's Medical Diagnosis.) 5. The normal pulse rate in the adult is about seventy to seventy-five a minute. For each degree of tempera- ture above the normal, the pulse rate is usually increased about eight or ten beats. INTERNAL MEDICINE. i. See French's "Practice of Medicine" (1907), page 780; or Osier's "Practice, of Medicine" (1909), page 504. 2. In auscultation of healthy lung the inspiratory sound is heard, and also a sound during the first part of expira- tion. It is called vesicular breathing. 3. Some diagnostic symptoms of secondary syphilis: Sore throat, mucous patches; the skin lesions or syphilides, which are characterized: By not itching, by being of a coppery or raw ham color, by being painless, by polymor- phism (macules, papules, pustules, etc., being present at the same time), and by being roughly symmetrical. In this stage may also appear ; iritis, periostitis, and alopecia. 4. The cardinal symptoms of exophthalmic goiter are : (1) Tachycardia, (2) goiter, (3) exophthalmos, and (4) tremor. 5. In renal colic: The pain is in the region of the affected kidney, it radiates down the thigh; there are in- tense rigors ; retraction of the testicle may be present ; also history of previous attacks or of calculi; the urine may be scanty, suppressed, or bloody. In hepatic colic: The pain is in the region of the liver, it radiates to the right scapula and toward the umbilicus; chills and sweats are common; also vomiting, and some- times symptoms of collapse and jaundice; calculi are found, if at all, in the feces. 6. Some of the causes of endocarditis, are : Acute articu- lar rheumatism, chorea, tonsillitis, scarlet fever, pneumonia, cancer, gout, diabetes mellitus, Bright' s disease, septicemia, gonorrhea. 7. The conditions which predispose to cerebral hemor- rhage are: Advanced age, rheumatism, gout, syphilis, al- coholic excesses, Bright's disease, prolonged muscular exer- tion, chronic lead poisoning, severe physical or mental ex- citement. 8. Cerebral vomiting is projectile in character, and is accompanied by little or no nausea, is continuous even after stomach is emptied; there is no salivation, no tenderness over liver or stomach. 208 MEDICAL RECORD. Gastric vomiting relieves the previous nausea, and re- turns on ingestion of food; salivation is present, also ten- derness over liver and stomach. 9. Typhoid fever gains entrance to the human body by the mouth, chiefly through water, ice, milk, or other foods. The entrance of typhoid fever into the human organism may be prevented by boiling all water that is to be used for drinking or for washing dishes, etc. ; milk should be boiled also; and no ice should be put in water or other drink or food; flies should be kept out of the house as far as possible, by means of screens or otherwise; all dis- charges from the sick person must be disinfected; all utensils, dishes, etc., used by the patient must be thorough- ly cleansed, and boiled every day; soiled linen must be soaked in a disinfectant solution before being washed, after each attendance on a patient, physicians, nurses, and others should wash their hands in a disinfectant ; thor- ough sterilization of all bedding, etc., must be performed after the disease is over. 10. Some points of diagnostic value in chronic interstitial nephritis, are: Increased arterial tension, urine increased in quantity and of low specific gravity, a few hyaline casts may be present, albumin is either absent or present in very small amount ; hypertrophy of the left ventricle, later on of the whole heart; a systolic murmur; uremia; retinitis, choked disc; anorexia, nausea, vomiting, diarrhea, cramps, numbness, dyspnea. OBSTETRICS. 1. (a) Deficient power of the uterine muscle may be caused by : "Overdistention of the uterus from plural preg- nancy or polyhydramnios; distention of the bladder or rectum; obliquities and displacements of the uterus; thin- ning of the uterine walls resulting from frequent and quickly repeated labors, or from degeneration of the uter- ine tissues; precocious or advanced age; general debility or feebleness of the woman from previous diseases, ener- vating habits, heat of climate, or of season, or the air of a superheated room; exhaustion of the woman from hem- orrhage or from lack of sleep or food. Uterine action is sometimes inefficient from uremia, and when there is mor- bid adhesion between the fetal membranes and uterine wall. Mental emotions : fear, grief, surprise, anxiety, disappoint- ment, and the presence of offensive persons or things will produce it. These last may depend upon idiosyncrasy or unaccountable personal antipathies." — (King's Manual of Obstetrics.) (b) Excessive power of the uterine muscle may be caused by: Abnormally large pelvis, small fetus, unusual relaxation of the maternal soft parts, nervous excitability or peculiar temperament of the woman. 209 MEDICAL RECORD. 2. Caput succedaneum is a swelling on the presenting part of the fetus, which is developed during birth. It is due to edema of that part of the fetus (the presenting part), which is not compressed by the maternal structure during uterine contraction. 3. Four important signs of pregnancy at the third month: Softening of the cervix; purplish hue of the vagina; amenorrhea, and the enlargement, pigmentation, hardening, and possible secretion in the mammary glands. 4. Pregnancy: The tumor is hard and does not fluctu- ate, is situated in the median line, and may give fetal heart sounds and movements; the cervix is soft, and the other signs of pregnancy are present. The rate of growth of the tumor, and the general condition of the patient's health may also help in arriving at a diagnosis. Uterine fibroid: Menstruation is irregular and some- times very profuse; absence of the signs of pregnancy; the tumor is nodular, firm, irregular in outline, and while generally placed somewhat centrally is not in the median line, and is not symmetrical ; the rate of growth is irregu- lar, being, as a rule, slow, and sometimes extending over years. 5. The indications for podalic version are: (1) In transverse presentations; (2) in placenta prsevia; (3) in malpresentations of the head; (4) in simple flattened pel- vis, and in minor degrees of pelvic contraction; (5) in pro- lapsed funis; (6) in sudden death of the mother; and (7) in any case where speedy delivery is imperative. 6. The changes occurring in the circulation at birth, are : The hypogastric arteries become obliterated, the foramen ovale closes, the Eustachian valve atrophies, the ductus arteriosus and ductus venosus become impervious and shrivel up. 7. Cystocele is a hernia of part of the bladder into the vagina, covered by the mucous membrane of the anterior vaginal wall. Rectocele is a hernia of the rectum into the vagina, covered by the mucous membrane of the posterior vaginal wall. The two conditions are generally found to- gether. Causes: Lacerated perineum, prolapsed uterus, relaxation of the structures forming the pelvic floor, and subinvolution of the vagina after labor. Treatment ^ con- sists in repair of the perineum, and sometimes, in addition, removal of the redundant tissue. For radical cure of cystocele: "The patient is placed in dorsal position. The posterior vaginal wall is kept out of the way with a weighted speculum. The cervix is drawn down with a bullet-forceps. With a pair of tenacula the sides of the prominence are drawn together in the median line in order to see how much of the wall is redundant and these points are marked with small nicks. Next, the whole 210 MEDICAL RECORD. surface is put on the stretch between four pairs of forceps — one at each of the sidemarks, one near the cervix, and one at the transverse ridge at the inner end of the urethra. With a pair of scissors curved on the flat, a strip about Y^ inch wide is cut out of the mucous membrane. Similar strips are removed on both sides until an oval is denuded. Finally a running suture of chromicized catgut is passed under the whole pared surface, uniting the edges from side to side." If necessary, a perineorraphy should be done at the same time. 8. Ergot should be employed in obstetric practice to pro- mote uterine contractions after the third stage of labor. It is contraindicated if the birth canal is not free and the os uteri is not dilated. 9. See Williams' "Obstetrics" (1909), pages 875 and 883; or Hirst's "Obstetrics" (1909), pages 728 and 732. 10. The premonitory symptoms of puerperal convulsions are : Headache ; tinnitus aurium ; dizziness ; pain over stomach ; digestive, visual, and nervous disturbances ; gen- eral debility; insomnia, vomiting, and vertigo. For pre- ventive treatment: (1) The amount of nitrogenous food should be diminished to a minimum; (2) the production and absorption of poisonous materials in the intestines and body tissues should be limited and their elimination should be aided by improving the action of the bowels, the kidneys, the liver, the skin, and the lungs; (3) the source of the fetal metabolic products and the peripheral irrita- tion in the uterus should, if necessary, be removed by evacuating that organ. GYNECOLOGY. 1. In the dorsal posture the patient lies on her back. In the left lateral prone posture the patient lies on her left side and chest, with the right knee .and thigh drawn up and her left arm behind her. In the knee-chest posture the patient rests on her knees and chest, with her thighs at right angles to the table on which she is resting. 2. Endocervicitis. Causes: Extension of inflammation from uterus or vagina, gonorrhea, sepsis, laceration, ever- sion, traumatism, suppressed menses, uterine displace- ments, subinvolution, pelvic tumors, or disease. Diagnosis is made from the history, leucorrhea, soft and swollen cervix, and patulous and eroded os. Treatment : Removal of cause, if possible; proper hygiene and clothing: relieve constipation ; abdominal massage ; hot vaginal douches ; ichthyol and glycerin tampons; dilatation, and curettage ; 3. Ectopic gestation. Diagnosis: "When extrauterine pregnancy exists there are: (1) the general and reflex symptoms of pregnancy; they have often comeon after an uncertain period of sterility; nausea and vomiting appear 211 MEDICAL RECORD. aggravated. (2) Then comes a disordered menstruation, especially metrorrhagia, accompanied with gushes of blood, and with pelvic pain coincident with the above symptoms of pregnancy; pains are often very severe, with marked tenderness within the pelvis ; such symptoms are highly suggestive. (3) There is the presence of a pelvic tumor characterized as a tense cyst, sensitive to the touch, actively pulsating; this tumor has a steady and progressive growth. In the first two months it has the size of a pigeon's egg; in the third month it has the size of a hen's egg; in the fourth month it has the size of two fists. (4) The os uteri is patulous; the uterus is displaced, but is slightly en- larged and empty. (5) Symptoms No. 2 may be absent until the end of the third month, when suddenly they be- come severe, with spasmodic pains, followed by the general symptoms of collapse. (6) Expulsion of the decidua, in part or whole. Nos. 1 and 2 are presumptive signs; Nos. 3 and 4 are probable signs; Nos. 5 and 6 are positive signs/' — (American Text-Book of Obstetrics.) Treatment consists in the removal of the product of con- ception by a laparotomy, as soon as the diagnosis is made. 4. Salpingitis. Causes: Gonorrhea, septic infection, displaced or subinvoluted uterus, fibroids, lacerated cervix. Pathology: "The inflammation usually extends all along the mucous membrane of the tube to the fimbriae and ovary. The abdominal, opening is closed by adhesions, thus pre- venting escape of the contents of the tube into the ab- dominal cavity. Resolution is rare. At first there is a hyperemia of the mucous membrane more or less intense; later, swelling and softening of the tubes, the tissues be- coming friable ; the fimbriae share in the swelling. The mucous membrane is covered with a glutinous pus. Usu- ally the abdominal opening now closes from adhesions. The uterine opening may remain patulous to permit the escape of the tubal contents. In some cases, however, the swelling of the mucous membrane is sufficient to close this ostium, and thus cause a retention cyst. The uterine end of the cyst may later open from pressure and the contents be discharged through the uterus at intervals. When the cyst contains clear mucus it is known as hydrosalpinx ; when blood is retained, hematosalpinx; when purulent, pyosalpinx. The dilatation usually occurs in the outer two-thirds of the tube. Extension of the inflammatory process beyond the mucous membrane into the muscular and areolar tissue may occur, producing hyperplasia of these structures and hypertrophy of the tube. Although the tube is very much enlarged, its caliber is frequently much decreased in size; it becomes lengthened and markedly tortuous. The tube and ovary may be bound together by adhesion in Douglas' cul-de-sac." (Wells.) 212 MEDICAL RECORD. Diagnosis: A dragging sensation in the neighborhood of the affected tube; colicky pain, which is increased on exertion or even on standing ; abdominal tenderness ; menstrual disorders, as amenorrhea, metrorrhagia, dys- menorrhea, menorrhagia ; dyspareunia; there may be septic symptoms and peritonitis ; sterility generally ensues. On examination there will be found a fullness in Douglas' pouch and one or both lateral f ornices ; in these latter will be felt either the tubes, distorted and possibly ad- herent, or a sausage-shaped tumor, which is very painful ; the uterus is retroverted or retroflexed, and may be bound down by adhesions ; there may be an intermittent expul- sion of pus, accompanied and preceded by a burning pelvic pain. (Wells.) The treatment of the acute form "consists in rest in bed, free purgation with Rochelle salts (3i every hour), hot vaginal douches, and hot applications to the abdomen. If the symptoms become more severe, celiotomy is indicated. The chronic form may be treated during the menstrual period by rest in bed, free purgation, hot vaginal douches, local applications of iodin to the cervix and vaginal vaults, and glycerin tampons. If these measures fail removal of the tube and ovary and replacing the retroverted uterus, etc., are necessary." 5. See Hirst's "Obstetrics" (1909), page 782. 6. Urethrocele. Causes: Traumatism during labor and stricture or tumor in urethra. Symptoms: Frequent and painful micturition; partial incontinence of urine ; retention of urine in the urethrocele, later becoming alkaline and undergoing decomposition. The bulging in the anterior vaginal wall can be seen and touched, and a sound passed into the urethra can be felt through the urethrocele. Differential Diagnosis: URETHROCELE. Indistinct bulging. Disappears on pressure. Tumor elastic and compressible, not tender on pres- sure. No pain on walk- ing or coitus. SUBURETHRAL ABSCESS. Prominent tumor. Only partially dis- appears, and pus may be squeezed out into urethra. Tumor fluctuating and prominent, very painful on pressure. Very painful. VAGINAL TUMOR. Prominent tumor. Does not disappear on pressure. Tumor firm. 213 MEDICAL RECORD. URETHROCELE. Only the vaginal and urethral wall between the examining finger and a sound in the urethra. SUBURETHRAL ABSCESS. The thickness of the intervening structure is in- creased^ by the presence of the abscess. VAGINAL TUMOR. The thickness of the intervening structure is in- creased by the tumor. i. Inguinal. -{ Direct (Compiled from Ashton's Gynecology.) SURGERY. i. See Rose and Carless' "Surgery" (1908), page 745; or Da Costa's "Surgery" (1908), page 708. 2. See Rose and Carless' "Surgery" (1908), page 1044; or Da Costa's "Surgery" (1908), pages 858 and 861. 3. See Rose and Carless' "Surgery" (1908), page 481; or Da Costa's "Surgery" (1908), pages 446 and 464. 4. See Rose and Carless' "Surgery" (1908), pages 1059 and 1061; or Da Costa's "Surgery" (1908), pages 891 and 894. . 5. Varieties of Hernia: Hernia may be classified: I. Anatomically: f Acquired Oblique i Congenital |v Infantile or encysted ( External ( Internal r Intraparietal Interstitial J Interparietal ^ Extraparietal [Incomplete, or Bubonocele.] Femoral. f Congenital Umbilical. < Of infants (.Of adults 4. Ventral. 5. Lumbar. 6. Obturator. 7. Diaphrag- matic. 8. Pudendal, etc. II. Clinically: Reducible irreducible, obstructed or in- carcerated, inflamed, and strangulated. 6. Carcinoma is desseminated chiefly through the lym- phatics ; less frequently by the circulation ; and occasion- ally by mechanical transportation in the movements of the body. 7. See Rose and Carless' "Surgery" (1908), page 231; or Da Costa's "Surgery" (1908), page 244. 8. See Rose and Carless' "Surgery" (1908), page 494; or Da Costa's. "Surgery" (1908), page 482. 2. 3- 214 MEDICAL RECORD. 9. See Rose and Carless' "Surgery" (1908), page 751; or Da Costa's "Surgery" (1908), page 708. 10. Five causes of swelling in the inguinal region: Inguinal hernia, iliac abscess, lymphadenoma, retained tes- ticle, and hydrocele of the spermatic cord. PEDIATRICS. 1. See French's "Practice of Medicine" (1907), pages 298 and 333; or Osier's "Practice of Medicine" (1909), pages 112 and 145. 2. See French's "Practice of Medicine" (1907), page 782; or Osier's "Practice of Medicine" (1909), page 507. NEUROLOGY. 1. The symptoms of cerebral compression, are: Head- ache, vertigo, vomiting, mental dullness, sometimes paraly- sis, contracted pupils, coma, and cyanosis. 2. Dementia is a general enfeeblement of all the mental powers. The more important forms of dementia, are : Primary, secondary, acute, chronic, senile, paretic, alcoholic, and syphilitic. 3. The diagnostic symptoms of multiple sclerosis, are: Nystagmus, scanning speech, intention tremor, exaggerated patellar reflex, ankle clonus, ataxia, vertigo, unsteady gait. LARYNGOLOGY AND RHIN0L0GY. i. See Rose and Carless' "Surgery" (1908), pages 832 and 834. 2. See Rose and Carless' "Surgery" (1908), page 868. OPHTHALMOLOGY AND OTOLOGY. ^ i. Glaucoma is a diseased condition of the eye, produced by increased intraocular pressure, and resulting in excava- vation and atrophy of the optic disc, and blindness. It is due to increase of the contents of the eye, hypersecretion, retention, old age, gout, rheumatism, nephritis. Symptoms: Visual disturbances, increased ocular tension, hazy and anesthetic cornea, sluggish and dilated pupil, shallow an- terior chamber, ciliary neuralgia, cupping of^ optic disc, blindness. Treatment: Myotics, such aseserine or pilo- carpine; massage of the eyeball; mydriatics are contrain- dicated; operative treatment may include paracentesis, iridectomy, or sclerotomy. >/ 2. Gonorrheal conjunctivitis. Symptoms: Swelling and redness of the eyes, the presence of a discharge which soon becomes purulent, the conjunctiva of the lids becomes thickened, the eyelids are edematous, pain is severe, and there is some fever. Diagnosis: From symptoms and find- ing the gonococcus in the discharge. Treatment: Protect the sound eye. Wash the eye carefully every half hour 215 MEDICAL RECORD. with a saturated solution of boric acid ; pus must not be allowed to accumulate. Two drops of a 2 per cent, solu- tion of nitrate of silver must also be dropped onto the cor- nea every night and morning. The eyes must be covered with a light, cold, wet compress. The patient must be isolated, and all cloths and compresses used must be burnt. In adults the irrigation must be frequent, about every half hour or hour. 3. "Acute catarrhal otitis media is frequently caused by acute coryza and the infectious fevers. There is a painless obstructed sensation in one or both ears, impairment of hearing, and tinnitus. The inflammation causes closure of the Eustachian tube. Inflation and aspiration of the middle ear and syringing and douching the nares and nasopharynx must be avoided. A moderate spray of Dobell's solution may be used. If pain is present, dry heat, in the form of hot-water bottle, hot stone wrapped in flannel, etc., may be applied. A few drops (100), warmed, of carbolic acid solution (1:40), or one of formalin (1:2000), may be in- stilled into the ear. "Acute purulent otitis media: Acute catarrhal otitis media, instead of undergoing resolution, may pass into acute purulent otitis media (especially in exanthemas) from the passage of pathogenic germs from the nasopharynx into the middle ear. The pain will become more intense, the hearing dull; tinnitus will become louder and more distressing, and fever usually sets in. Dry heat allays the pain. Warmed water or warmed carbolic acid solution (1:40) may be used. Inflations, aspirations, etc., should be avoided. If the nares are filled with tough secretions a spray of Dobell's solution may be used. If the pain con- tinues over six hours in a child or over twelve hours in an adult without spontaneous perforation of the tympanic membrane paracentesis of that structure should be per- formed. The concha and meatus should be smeared with petrolatum to avoid chapping, and the secretions should be gently mopped off as they appear. Under this treatment the ear usually returns to normal in two to three weeks." — (Gould and Pyle's Pocket Cyclopedia of Medicine and Surgery.) ETIOLOGY AND HYGIENE. i. See French's "Practice of Medicine" (1907), pages 180 and 194; or Osier's "Practice of Medicine" (1909), pages 193 and 207. 2. To see that there is no connection between the escape pipe of the bath and that of the water closet. 3. Filter beds, with fine sand. 4. If it is a proper water closet, with adequate plumbing, etc., it does not matter where it is placed. If a "privy" 216 MEDICAL RECORD. is meant, it should be placed below the farmhouse, so that water will flow from the farmhouse to the privy, rather than the reverse. 5. The Pure Food and Drug Act, if properly enforced, will do much to prevent the adulteration of articles of food and drink ; it will do away with many of the so-called preservatives; and people will know what they are taking when they indulge in proprietary "remedies." At the same time the publication of the amount of opium or morphine in certain "pacifiers" will doubtless save many lives; and no one can drink peruna and claim ignorance of its enor- mous alcoholic content. MEDICAL JURISPRUDENCE. i. There are no characteristic signs of death by mor- phine. The only lesions are those that may usually be observed after death from asphyxia. The blood is dark and fluid ; the brain, meninges, and lungs may be congested ; the bladder is usually full of urine. 2. A delusion is a belief in something which has no real existence, but is purely imaginary; and out of which the person cannot be reasoned. An illusion is a false or perverted impression, received through one of the senses. An hallucination is the same as an illusion, but without any material basis. If an individual believes himself to be made of glass, and is afraid of being touched lest he be broken, he is suffering from a delusion. If the whistling of the wind is mistaken for a voice telling a person to do a certain thing — that ^ would be an illusion. If a person fancied he heard a voice when there was nothing at all to be heard, that would be an hallucination. STATE BOARD EXAMINATION QUESTIONS. Kansas State Board of Medical Registration and Examination, anatomy and histology. 1. Locate the brachial plexus and its branches, naming the latter. & 2. Describe the medulla oblongata. 3. Locate and describe a femoral hernia and name its coverings, beginning with the surface. 4. Describe the intestinal tract and name its divisions. 5. Locate and describe the omentum, giving the histol- ogy of the same. 6. Describe the valvulae conniventes. 217 MEDICAL RECORD. 7. Locate and describe the pancreas, giving its histology. 8. Give the histology of the arteries. Does it differ from the histology of the veins? If so, how? 9. Describe the sympathetic nerve, naming its divisions, and number of ganglia in each. 10. How many bones are there in the human skeleton? CHEMISTRY AND TOXICOLOGY. i. What is galvanism? 2. How can it be demonstrated that hydrogen is lighter than air? 3. What is analysis and what is synthesis? 4. What is the effect of inhaling air rich with ozone on the respiratory organs? 5. In what manner does arsenic prove poisonous? 6. How does CO act as a poison? 7. What is the action of KOH on the tissues? 8. What is the antidote for acute poisoning by HgCla? 9. What is the reaction of blood during gout? 10. What is Trommer's test for sugar in urine? OBSTETRICS. 1. Write a page on deformities of the pelvis. 2. What would you do in a case of postpartum hemor- rhage? 3. How would you treat a case of hour-glass cpntrac- tion? 4. Write a page on puerperal eclampsia. 5. How would you treat a case of pelvic cellulitis? 6. Into how many stages is labor divided? 7. How would you treat a case of face presentation? 8. How would you treat a case of adherent membranes? 9. Write a page on the use of the forceps. 10. How would you treat fibroid tumors of the uterus? PATHOLOGY. 1. Define gangrene. 2. What is a sarcomatous tunapr? Give its pathology. 3. Define chronic gastritis and give its pathology. 4. Give symptoms, etiology, pathology, diagnosis and prognosis of herpes zoster. 5. Give symptoms, etiology, and prognosis of erysipelas. 6. Give etiology, symptoms, diagnosis, and prognosis of neuritis (multiple). 7. Define lithemia. 8. Define purpura hemorrhagica. 9. Give differential diagnosis of septicemia and pyemia. 10. Describe the pathology of rachitis. 218 MEDICAL RECORD. BACTERIOLOGY. i. How do bacteria multiply? 2. What is essential to the life of bacteria? 3. Name and describe the malarial parasites. 4. What disease does the bite of an infected Stegomyia fasciata produce? 5. Name five culture media. 6. Name and describe the pus-producing germs. 7. Describe Widal's test for typhoid fever. 8. What are leucocytes, and what occurs when they come in contact with pathogenic bacteria ? 9. What are ptomaines and toxins? 10. What are sterilization, antiseptics, disinfectants, and germicides ? PHYSIOLOGY. 1. What are the functions of the spinal cord? 2. What is the origin of urea and of uric acid? 3. (a) Describe the vasomotor nervous system and explain its functions, (b) Where is the vasomotor center located ? 4. (a) Give the function of the suprarenal glands, (b) What is result of their extirpation? 5. What kind of membrane lines the mastoid cells, and why? 6. Explain the portal circulation. 7. (a) What are the functions of bile? (b) Give its con- stituents. 8. Describe the pleurae, giving kind of tissue and func- tions. 9. (a) Give functions of the cerebellum, (b) What is the result of its extirpation? 10. Give the functions of the medulla oblongata, (a) Name the "centers" located in the bulb. SURGERY. 1. What class of patients take ether better than chloro- form, and why? What class take chloroform better, and why ? 2. What are the signals of danger in general anesthesia ? 3. How would you treat a suppurating cavity of the thorax? 4. What is the proper surgical treatment of a chronic varicose ulcer of the leg? Give details. 5. What is osteoplasty, and in what part of the body is it most frequently called for? Give an example. 6. Give the cause and treatment of painful cicatrix, ad- herent cicatrix, contracted cicatrix, and exuberant cicatrix. 219 MEDICAL RECORD. 7. What kinds of tumors are most safely removed? What kinds are the least safely removed? 8. How would you treat an ingrowing toenail? Give full details. 9. What is the best surgical treatment for hemorrhoids? Give details. 10. What bone in the body is frequently fractured and is the most difficult of all bones to reunite by bony union? How should it be treated when fractured? Give details. OPHTHALMOLOGY, OTOLOGY, RHINOLOGY, AND MEDICAL JURIS- PRUDENCE. 1. Name some causes of ozena. 2. Discuss the pathological characteristics of nasopharyn- geal adenoids. 3. Define strabismus. What causes it? 4. Describe the crystalline lens and give its relations. 5. The vast majority of all the diseases of the ear have their origin in inflammations of what particular membrane? 6. Prescribe for chronic case of otitis media purulenta. 7. Nasal polypi — give diagnosis and surgical treatment. 8. What do you understood by medical jurisprudence? 9. What constitutes a dying statement, and what condi- tions are necessary to make it admissible as evidence in a court of justice? 10. Give diagnostic symptoms between diphtheria and follicular tonsillitis. THEORY AND PRACTICE. 1. Write a page on epidemics. 2. Write a page on the treatment of typhoid fever. 3. Give diagnosis and treatment of scarlet fever. 4. Give treatment of erysipelas. 5. Give diagnosis and treatment of rickets. 6. Give diagnosis and treatment of acute laryngitis. 7. Write a page on pneumonia. 8. Describe the different murmurs of the heart and ten what they indicate. 9. Give treatment for acute peritonitis. 10. Write a page on Bright's disease. MATERIA MEDICA. 1. In what disease is opium used principally? 2. Name the excitomotors. 3. What are the preparations and doses of conium? 4. Is ether ever used as a cardiac stimulant? 5- How should poisoning by digitalis be treated? 6. What are the medicinal uses of ipecac? 7. What substances are incompatible with belladonna? 220 MEDICAL RECORD. 8. What are the effects, uses, and doses of calcium chloride? 9. What are the preparations and doses of gold salts? 10. Name the mineral tonics. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Kansas State Board of Medical Registration and Examination. ANATOMY. 1. See Cunningham's "Anatomy" (1909), page 622 ; or Gray's "Anatomy" (1908), page 994. 2. See Cunningham's "Anatomy" (1909), page 481; or Gray's "Anatomy" (1908), page 874. 3. See Gray's "Anatomy" (1908), page 1545. 4. See Cunningham's "Anatomy" (1909), page 1064; ° r Gray's "Anatomy" (1908). page 1290. 5. See Cunningham's "Anatomy" (1909), page 1049; or Gray's "Anatomy" (1908), page 1264. 6. See Cunningham's "Anatomy" (1909), page 1062; or Gray's "Anatomy" (1908), page 1299. 7. See Cunningham's "Anatomy" (1909), page 1124; or Gray's "Anatomy" (1908), page 1355. 8. See Cunningham's "Anatomy" (1909), page 781; or Gray's "Anatomy" (1908), page 586. 9. See Cunningham's "Anatomy" (1909), page 703; or Gray's "Anatomy" (1908), page 1077. 10. There are 206 named bones in the human skeleton. CHEMISTRY AND TOXICOLOGY. i. By the term Galvanism is meant current electricity derived from chemical action, in opposition to that pro- duced by heat or induction. The term is no longer used scientifically; but is laxly employed to denote the constant current as distinguished from the induced current (which is sometimes called Faradism or Faradization) . 2. Soap-bubbles or a toy balloon, if filled with hydrogen gas, will rise rapidly in the air. 3. Analysis is the splitting up of a compound into its elements or into simpler compounds. Synthesis is the build- ing up of a compound from elements or from simpler compounds. 4. It causes severe coryza and hemoptysis. 5. By the ingestion of flypaper, or the water in which it has been placed, poisoning by elementary arsenic may be caused. By the inhalation of hydrogen made from zinc and sulphuric acid containing arsenic, poisoning by Arsin may 221 MEDICAL RECORD. be produced. Arsenic trioxide can cause poisoning by being absorbed from the mouth, stomach, rectum, vagina, or urethra; or by absorption from the skin in the use of parasiticides or cancer cures containing arsenic; also by inhalation of dust from wallpapers containing arsenic; from clothes dyed with arsenic; and by the ingestion of rat poisons, etc. 6. By uniting with the hemoglobin of the blood and forming a more stable compound than oxyhemoglobin. In this way the power of the red corpuscles to carry oxygen from the air to the tissues is destroyed; and asphyxia is thus produced. 7. > It acts as a caustic on living tissues ; and disintegrates all tissues, whether, dead or alive. 8. White of egg, in not too large a quantity, and fol- lowed by an emetic. 9. Alkaline ; but the degree of alkalinity may be lowered, and uric acid crystals may be found in the blood. 10. Place in a test tube some urine free from albumin; add a few drops of a solution of cupric sulphate, and then some liquor potassse (about half as much as the urine) ; shake and boil. A yellow or red precipitate is formed in the presence of sugar. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), page 679; or Hirst's "Obstetrics" (1909), page 446. 2. In postpartum hemorrhage: Grasp the uterus at once, through the abdominal wall, and massage it firmly. Any- thing in the uterus should at once be cleaned out. Pass one hand into the uterus, and with the other on the outside make firm pressure. A hypodermic of ergotin, or ergot can be given by an assistant. An intrauterine douche of hot sterilized water (about 115 F.) may be given. Sometimes a very thorough packing and plugging of gauze of uterus and vagina may be necessary. Whatever is done must be done promptly; and everything likely to be needed for this emergency should be prepared beforehand in every labor. 3. First, give a hypodermic of morphine and atropine, or a dose of chloral or an anesthetic, and then, with one hand in the vagina, gently introduce the index and middle fingers into the uterus and through the constricting band. After a time the resistance of the constriction will be thus overcome. By pressing the uterus downward, the ringers and the border of the placenta are brought in con- tact. Effort is then made to bring part of the placental mass through the constriction; the placenta being removed as in case of adherent placenta. 4. Puerperal eclampsia is an acute morbid condition, oc- curring during pregnancy, labor, or the puerperal state, and 222 MEDICAL RECORD. is characterized by tonic and clonic convulsions, which af- fect first the voluntary and then the involuntary muscles; there is total loss of consciousness, which tends either to coma or to sleep, and the condition may terminate in re- covery or death. Etiology: Uremia, albuminuria, imper- fect elimination of carbon dioxide by the lungs, medicinal poisons, septic infection ; predisposing causes are renal dis- ease and imperfect elimination by the skin, bowels, and kidneys. Symptoms: Headache, nausea, and vomiting, epigastric pain, vertigo, ringing in the ears, flashes of light or darkness, double vision, blindness, deafness, mental dis- turbance., defective memory, somnolence ; symptoms easily explained by the circulation of toxic blood through the nerve centers. These may be preceded by lassitude, and accompanied by constipation, or by diarrhea. Headache is perhaps the most significant and common warning symptom. In bad cases the urine is reduced in quantity (almost sup- pressed), very dark in color, its albumin greatly increased, so that it becomes solid on boiling. Next comes the final catastrophe of convulsions. The convulsive fit begins with twitching of the facial muscles, rolling and fixation of the eyeballs, puckering of the lips, fixation of the jaws, pro- trusion of the tongue, etc., soon followed by violent spasms of the muscles of the trunk and limbs, including those of respiration ; hence lividity of the face and stertorous breath- ing, biting of the tongue, opisthotonus, etc. The fit lasts fifteen or twenty seconds, ending in partial or complete coma, possibly death ; or consciousness may return, to be followed by other convulsions. For preventive treatment: (i) The amount of nitrogenous food should be diminished to a minimum ; (2) the production and absorption of poisonous materials in the intestines and body tissues should be limited and their elimination should be aided by improving the action of the bowels, the kidneys, the liver, the skin, and the lungs; (3) the source of the fetal metabolic products and the peripheral irritation in the uterus should, if necessary, be removed by evacuating that organ. The curative treatment includes: (1) Controlling the convulsions (by chloroform, veratrum, or chloral) ; (2) elimination of the poison or poisons which are presumed to cause the convulsions; (3) emptying the uterus under deep anesthesia, by some method that is rapid and that will cause as little injury to the woman as possible. 5. The vagina should be made as aseptic as possible, by means of vaginal douches of bichloride of mercury 1 :2,ooo. The vaginal vault and the cervix uteri can then be painted with tincture of iodine ; sometimes the insertion of a vaginal suppository containing about thirty grains of iodoform is of benefit. In case suppuration occurs, the abscess should be opened; if it bursts into the rectum or 223 MEDICAL RECORD. vagina, measures must be instituted for drainage and dis- infection. Very frequently an abdominal operation is neces- sary. Antipyretics should be given for the fever; and for the pain cold compresses or ice bags should be applied to the perineum and lower part of the abdomen. 6. Labor is divided into three stages: (i) The first be- gins with the onset of labor, and lasts till the os is com- pletely dilated; (2) the second begins with the complete dilation of the os and ends with the complete expulsion of the child; (3) the third ends with the complete expulsion of the placenta and membranes. 7. If the chin is presenting anteriorly, expectant treat- ment may suffice; but care must be taken to observe that the chin does not rotate backwards. Spontaneous version may occur, and the presentation become a vertex one. Fail- ing this, or as a means of favoring this, postural treatment, such as Walcher's position, has been recommended. If, in spite of this, engagement has not occurred, cephalic version is indicated, care being taken not to rupture the membranes. If this is not successful, podalic version should be tried. If, after all these manipulations, the child is still alive and the head is engaged, symphyseotomy is indicated; if the child is dead, craniotomy should be performed. 8. See ixirst's "Obstetrics" (1909), page 436. 9. See Williams' "Obstetrics" (1909), page 400: or Hirst's "Obstetrics" (1909), page 811. 10. See Rose and Carless' "Surgery" (1908), page 1282. PATHOLOGY. 1. Gangrene is the complete and permanent loss of vitality in a considerable area of tissue. 2. A sarcomatous tumor is one arising from connective tissue, with excessive cell formation and very little intercel- lular substance. The cells are either embryonic or imper- fectly developed connective tissue cells. Sarcomata are always mesoblastic in origin; their blood supply is abun- dant, and it is through this channel that they are dis- seminated; of their lymphatics and nerve supply nothing is known. In gross appearance sarcomata are of a more or less homogeneous nature, the color depending upon the quantity of blood present ; occasionally a milky fluid can be expressed, but there is never anything corresponding to the "cancer- juice" of carcinomata. Sarcomata may undergo various secondary changes, such as fatty degeneration, hemorrhages, and mucoid softening. Sarcomata are malig- nant, hence they have a tendency to spread to distant organs (metastasis), are heterologous, have no definite limiting capsule, tend to infiltrate the surrounding tissues, tend to recur after removal, and cause cachexia and death. They have been classified in a variety of ways: (1) according 224 MEDICAL RECORD. to the cells, as round cell sarcoma, spindle cell sarcoma, giant cell sarcoma, mixed cell sarcoma; (2) according to the stroma, as fibrosarcoma, myxosarcoma, chondrosarcoma, osteosarcoma; and (3) according to secondary changes, as melanosarcoma, liposarcoma, chloroma* 3. See French's "Practice of Medicine" (1907), page 734; or Osier's "Practice of Medicine" (1909), page 459. 4. See French's "Practice of Medicine" (1907), page 994; or Osier's "Practice of Medicine" (1909), page 900. 5. See French's "Practice of Medicine" (1907), page 218; or Osier's ''Practice of Medicine" (1909), page 210. 6. See French's "Practice of Medicine" (1907), page 980; or Osier's "Practice of Medicine" (1909), page 998. 7. Lithemia is a condition due to imperfect metabolism, and is characterized by an accumulation of uii- acid or urates in the blood. It differs from gout in the absence of joint involvement. 8. Purpura Hemorrhagica is a disease of unknown or- igin, and is characterized by hemorrhages into the skin and mucous and serous membranes, and usually runs a rapid and fatal course. 9. Septicemia begins with a rigor, followed by a rise of temperature up to about 104 F., which remains constant. The pulse is weak and progressively rapid; there is an- orexia and constipation, which is followed by diarrhea ; the urine contains albumin; the temperature may become subnormal. There are no repeated^ rigors and no secon- dary (metastatic) abscesses. Pyemia begins with a rigor, which may last for half an hour, and is repeated every one or two days. The temperature rises as in septicemia, but rapidly falls, and at the same time the patient suffers a profuse perspiration. The pulse is weak and rapid ; there is anorexia; and there may be delirium, with jaundice and signs of abscesses in the lungs, joints, etc. In pyemia there are repeated rigors and secondary abscesses. 10. See French's "Practice of Medicine" (1907), page 932; or Osier's "Practice of Medicine" (1909), page 426. BACTERIOLOGY. 1. Bacteria multiply by fission and by sporulation. 2. Most bacteria require (1) proper temperature, gen- erally at or near that of the body ; (2) oxygen is generally needed, those that cannot live without it being called aerobic, and those that can grow without it, anaerobic; (3) nutriment of a proper kind, containing both organic and inorganic material; (4) a slight degree of moisture; (5) a medium of slightly alkaline reaction ; and (6) rest. Indi- vidual bacteria may require modifications of the above essen- tials. 225 MEDICAL RECORD. 3. See French's "Practice of Medicine" (1907), page 233; or Osier's "Practice of Medicine" (1909), page 12. 4. Yellow fever. 5. Gelatin, agar, potato, bouillon, and blood-serum. 6. The pus-producing bacteria are: staphylococcus pyo- genes aureus, staphylococcus pyogenes albus, staphylococ- cus pyogenes citreus, staphylococcus cereus aureus, staphy- lococcus cereus albus, staphylococcus cereus flavus; strep- tococcus pyogenes; micrococcus tetragenus, micrococcus pyogenes tenuis; gonococcus; pneumococcus ; bacillus pyo- cyaneus, bacillus typhosus, and bacillus tuberculosis. 7. The Widal test: "Three drops of blood are taken from the well-washed aseptic finger tip or lobe of the ear, and each lies by itself on a sterile slide, passed through a flame and cooled just before use; this slide may be wrapped in cotton and transported for examination at the laboratory. Here one drop is mixed with a large drop of sterile water, to redissolve it. A drop from the summit of this is then mixed with six drops of fresh broth culture of the bacillus (not over twenty-four hours old) on a sterile slide. From this a small drop of mingled culture and blood is placed in the middle of a sterile cover-glass, and this is inverted over a sterile hollow-ground slide and examined. A posi- tive reaction is obtained when all the bacilli present gather in one or two masses or clumps, and cease their rapid movement inside of twenty minutes." — (From Thayer's Pathology.) 8. Leucocytes are white blood corpuscles. When they come in contact with pathogenic bacteria, if the conditions are favorable, they devour and destroy the bacteria (phago- cytosis) ; sometimes, however, the bacteria manage to de- stroy the leucocytes. 9. Ptomaines are the putrefactive products of dead ani- mal tissues or fluids. Toxins are the products of pathogenic bacteria or of pto- maines or leucomaines, and are actively poisonous. 10. Sterilization is the process of freeing a substance from the live bacteria that may be on it or in it. i Antiseptics are agents which prevent or restrain putre- faction. Disinfectants are agents which restrain infectious diseases by destroying or removing their specific poisons. Germicides are agents whch destroy bacteria and their germs. PHYSIOLOGY. 1. The functions of the spinal cord are: (1) the conduc- tion of nerve impulses ; (2) reflex action ; (3) coordination ; it also contains special centers which preside over definite functions. 226 MEDICAL RECORD. 2. Urea is derived from the nitrogenous food ingested; it is manufactured by the cells of the liver. Uric acid: "In man uric acid has a twofold origin; one portion, coming from the breaking down of the nuclein- containing tissues or cell elements of the man's own body, and hence is of endogenous origin, while the other portion — usually the larger — is of exogenous origin, coming from the transformation of free and combined purin compounds present in the food." (Chittenden.) 3. The vasomotor nervous system consists of (1) a vasomotor center in the bulb, (2) of some subsidiary centers in the spinal cord, and (3) of vasomotor nerves, which are of two kinds: (a) those causing constriction of the vessels, and so-called vasoconstrictor nerves; and (b) those causing dilatation of the vessels, and so-called vaso- dilator nerves. These nerves supply the muscle tissue in the walls of the blood-vessels and regulate their caliber, thus influencing the quantity of blood supplied to a part; at the same time they regulate the quality of blood supplied to a part; they also regulate the nutrition of a part, also secretion and heat production. They are concerned, too, in the control of the heart-beat. The center is in the medulla, in the floor of the fourth ventricle, near the calamus scrip- torius. 4. The function of the suprarenal glands is unknown; it is supposed that they are able to destroy or remove some toxic substance produced elsewhere in the body. Re- moval of these glands is rapidly followed by death. 5. The mastoid cells are lined by epithelium, continuous with that of the tympanic cavity. 6. See Cunningham's "Anatomy" (1909), pages 901 and 1 120; or Gray's "Anatomy" (1908), pages 768 and 769. 7. The functions of the bile are: (1) to assist in the emulsifkation and saponification of fats; (2) to aid in the absorption of fats; (3) to stimulate the cells of the intestine to increased secretory activity, and so promote peristalsis, and at the same time tend to keep the feces moist; (4) to eliminate waste products of metabolism, such as lecithin and cholesterin ; (5) it has a slight action in converting starch into sugar ; (6) it neutralizes the acid chyme from the stomach, and thus inhibits peptic digestion ; (7) it has a very feeble antiseptic action. The constituents of the bile may be shown in the follow- ing table, which presents the averages of three analyses given by Hammarsten ; the results are given in parts per thousand : Water 971.380 Solids 28.620 Mucin and pigments 4.910 227 MEDICAL RECORD Bile salts 12.197 Taurocholate 2.431 Glycocholate 9.766 Fatty acids from soaps 1.243 Cholesterin 1.200 Lecithin and fats 0.970 Soluble salts 7.360 Insoluble salts 0.317 8. See Cunningham's "Anatomy" (1909), page 977; or Gray's "Anatomy" (1908), page 1391. Function of pleura: With the pleural fluid, to prevent friction in the movements of the lungs. 9. The functions of the cerebellum are: (1) coordina- tion, (2) equilibrium. Removal of the cerebellum causes loss of these functions. 10. The functions of the medulla are: (1) Conduction of nerve impulses and impressions, (2) as an independent reflex center. The "centers" located in the bulb are: (1) center for mastication, (2) for secretion of saliva, (3) for sucking, (4) for deglutition, (5) for vomiting, (6) for voice, (7) center for expression (8) cardiac centers, (9) respiratory centers, (10) vasomotor centers. SURGERY. 1. See Rose and Carless' "Surgery" (1908), page 1326; or Da Costa's "Surgery" (1908), page 1028. 2. The danger signals are: (1) lividity or extreme pallor of the face, (2) feeble, irregular, or intermittent pulse, (3) slow and shallow respiration, (4) dilatation of the pupils during deep narcosis. 3. See Rose and Carless' "Surgery" (1908), page 928; or Da Costa's "Surgery" (1908), page 774. 4. See Rose and. Carless' "Surgery" (1908), pages 94 and 352; or Da Costa's "Surgery" (1908), page 396. 5. By osteoplasty is meant the transplantation of bone (with periosteum). It is most frequently performed on the skull. 6. Painful cicatrix is caused by the pressure of a con- tracting cicatrix upon the cut end of a nerve or by the inclusion of a nerve in the scar of an amputation stump. In the former case the painful part should be excised; in the latter the stump must be opened and the end of the affected nerve removed. Adherent cicatrix is caused by simultaneous injury (such as burns or scalds) to contiguous and approximated parts, such as the fingers, or the pinna and the side of the head. A plastic operation is indicated. Contracted cicatrix is most apt to occur in the flexure of a joint; a serious burn of the hand may cause flexion- 228 MEDICAL RECORD contracture of the fingers. The treatment is to divide the cicatrix, dissect out the scar, and follow with skin-grafting. Exuberant cicatrix consists of a hyperplasia of scar tissue, it is most often found in tuberculous patients, and is of unknown etiology. Excision is useless, as it is very apt to recur. Sometimes it disappears spontaneously. 7. Benign tumors are most safely removed; and malig- nant tumors are least safely removed. 8. Ingrowing toenail: 'The essential point is to remove both the edge of the nail and that portion of the matrix from which it grows. The following operation will be found satisfactory : Sterilize the toe as completely as pos- sible and tie a rubber band around its base; inject a few drops of a eucaine or stovaine solution along, the edge of the nail and beneath it as far back as the second phalanx. Make an incision through the nail and overlying skin and matrix in about one-fourth of an inch from the edge of the nail. The overlying skin is next dissected free from the edge of the nail and its matrix. The portion of the nail marked out by the first incision is then dissected out with its matrix, care being taken that all of the matrix corresponding to the nail is removed. The wound is irri- gated with a 1 to 2000 bichloride solution and closed by wrapping a gauze dressing around the toe and securing it by a bandage firmly applied. The rubber bandage is next removed. The wet dressing should be renewed daily for a few days, and after this time a dry dressing may be em- ployed." — (Wharton's Minor Surgery.) 9. See Rose and Carless' "Surgery" (1908), page 1152; or Da Costa's "Surgery" (1908), page 1015. 10. The patella. It is best treated by open operation anu wiring. OPHTHALMOLOGY, OTOLOGY, RHINOLOGY, AND MEDICAL JURIS- PRUDENCE. 1. (1) Atrophic nasal catarrh, due to syphilis, glanders, caries, or necrosis of the nasal bones; (2) ulcers ot a syphilitic, lupoid, or tuberculous origin; (3) foreign bodies and new growths in the nose or nasopharynx. 2. Adenoids consist of lymphoid tissue, which is com- posed of masses of round cells held together by connective tissue. Mucous glands may be found in the deeper parts of the lymphoid tissue; and the whole is covered with cil- iated columnar epithelium. • t 3. Strabismus, or squint, is a condition in which the lines of sight of the two eyes are not directed towards the same object of vision. The causes are: (1) disturbances of equilibrium of the ocular muscles; (2) errors of refraction; (3) opacities in the cornea or lens; (4) intraocular disease. 229 MEDICAL RECORD 4. See Cunningham's " Anatomy" (1909), page 736; or Gray's "Anatomy" (1908), page 1140. 5. The membrana tympani. / 6. $. Acidi borici * gr. xxx Zinci sulphatis gr.xvj Glycerin 3ij Aquas destillatse 3ij- M. Sig. A few drops to be instilled into the ear several times a day. 7. See Rose and Carless' "Surgery" (1908), page 832. 8. Medical jurisprudence is the application of the knowl- edge of any of the branches of medicine to the problem and requirements of the law. 9. Any statement made by a dying person who believes that he cannot recover and that he is, at that very time, in actual danger of death. The statement need not be sworn to; it should be voluntary and sincere; and it is admissible as evidence in a court if the individual dies. - 10. In diphtheria the onset is more gradual ; the temper- / ature rises to about 101 to 103 F. ; the tonsils are not much enlarged; there is an exudate of a thick grayish mem- brane which is very adherent, is removed only with diffi- culty, and leaves a bleeding surface; this membrane soon re-forms and may be found on the fauces and pharynx as well as on the tonsils; in the exudate the Klebs-Loffler bacilli may be found. In follicular tonsillitis the onset is more sudden ; the tem- perature may be a little higher than that of diphtheria ; there is no membrane, but the tonsils are red and swollen, and in the crypts are seen white cheesy spots or plugs, which consist of broken-down epithelium, and are easily brushed away; Klebs-Loffier bacilli are not found. THEORY AND PRACTICE. I. Epidemic diseases are such as attack, either simulta- neously or in rapid succession, a large number of persons in the same locality, or spread rapidly over a large territory. The causes of these epidemic outbursts are not known. "They have been attributed to climatic and meteorological conditions, accumulation of susceptible persons, facilities for convection or transmission, and (as regards cholera and other 'filth-diseases') imperfect sanitation. Scarlet fever, in temperate climates, where it has established itself permanently, tends to become epidemic at intervals of about five years; measles at intervals of about two years. Whooping cough is more irregular than either, but on an average becomes prevalent every second year. Diphtheria shows no very marked periodicity, apart from its depend- ence upon season, and enteric fever none. The liability to each kind of infection varies in man according to age and 230 iMEDICAL RECORD. sex, as well as locality, climate, season, and surroundings. Similar variation occurs among the different races of men. and still more conspicuously among the different genera and species constituting the animal kingdom." 2. See French's "Practice of [Medicine" (1907), page 109; or Osier's "Practice of [Medicine" (1909), page 99. 3. See French's "Practice of [Medicine" (1907), pages 317, 322 and 324; or Osier's "Practice of Medicine" (1909), pages 132, 136, and 138. 4. See French's "Practice of [Medicine" (1907), page 221; or Osier's "Practice of [Medicine" (1909), page 213. 5. See French's "Practice of Medicine" (1907), page 933; or Osier's "Practice of [Medicine" (1909), page 428. 6. See French's "Practice of Medicine" (1907), page 645; or Osier's "Practice of Medicine" (1909), page 597. 7. See "French's "Practice of Medicine" (1907).. page 151 ; or Osier's "Practice of Medicine" (1909), page 164. 8. (1) A systolic murmur, soft and blowing, heard best at the apex, and transmitted to the left axilla and toward the angle of the left scapula, indicates mitral regurgitation. (2) A presystolic murmur, harsh and rough, heard best very near the apex, and not transmitted, denotes mitral stenosis. (3) A diastolic murmur, soft, heard best in the second right intercostal space, and transmitted down the sternum or toward the apex, denotes aortic regurgitation. (4) A systolic murmur, harsh, heard best in the second right intercostal space, and transmitted into the carotids, denotes aortic stenosis. (5) A systolic murmur, heard best over the lower end of the sternum, denotes tricuspid regur- gitation. (6) A presystolic murmur, heard best over the ensiform cartilage, and not transmitted, denotes tricuspid stenosis. (7) A diastolic murmur, heard best in the second left intercostal space, denotes pulmonary regurgitation. (8) A systolic murmur, heard best in the second left inter- costal space, and not transmitted to the large vessels of the neck, denotes pulmonary stenosis. (9) A murmur, usually systolic, soft, and blowing, heard best over the pulmonic area, associated with evidences of chlorosis or anemia, and affected by the position of the patient, is a hemic or func- tional murmur, and denotes as a rule an impoverished con- dition of the blood. 9. See French's "Practice of [Medicine" (1907), page 868; or Osier's "Practice of Medicine" (1909), page 591. 10. See French's Practice of Medicine" (1907), pages 895, 900, 904; or Osiers "Practice of Medicine" (1909)* pages 690, 693, and 700. MATERIA MEDIC A. 1. In diabetes; particularly diabetes mellitus. 2. Nux vomica and ignatia (and their alkaloids strych- 231 MEDICAL RECORD nine and brucine), thebaine, ammonia, ether, chloroform, opium, ergot, alcohol in small doses. 3. Conium, three grains; fluid extract of conium, three minims. 4. Yes; on account of the rapidity of its action, ether is a very valuable cardiac stimulant. 5. The patient must be kept in the recumbent position; the stomach should be washed out with infusion of tea; give stimulants and keep the patient warm; tannic acid may be given, as the chemical antidote; and tincture of aconite, as the physiological antidote. 6. Ipecac is used externally as an antiseptic, in cases of anthrax. Internally as a stomachic, an expectorant, an emetic, a diaphoretic, and a cholagogue. It is given in cases of dyspepsia, dysentery, bronchitis, asthma, croup, and in the vomiting of pregnancy. 7. The caustic alkalies are incompatible with belladonna. 8. It is an irritant; applied externally it hastens the coagulation of the blood and makes a firmer clot. It is used in cases of gastric catarrh and fermentative dyspepsia, in hematemesis and hemoptysis, in glandular swellings of tuberculous patients. It has also been employed in the treat- ment of pneumonia and phthisis. The dose is seven and a half grains. 9. Auri et sodii chloridum is the only official gold salt; dose, one-tenth of a grain. 10. Iron, manganese, arsenic, bismuth, and phosphorus. STATE BOARD EXAMINATION QUESTIONS. State Board of Health of Kentucky. ANATOMY. 1. Describe (a) the gracilis, (b) gastrocnemius, (c) rec- tus femoris, giving origin and insertion of each. 2. Describe the pancreas. 3. Name the structures to be divided in operating for strangulation of an oblique inguinal hernia. 4. Describe the fourth cervical vertebra and distinguish it from the fourth dorsal vertebra. 5. Bound the axilla and name and give relations of structures in axillary space. 6. Name the muscles, nerves, and arteries severed by a cross section of the thigh at the junction of the middle and lower thirds. 7. Describe (a) the superficial and deep palmar arches, (b) the brachial artery, branches and relationship. 8. Describe and give contents and relations of parts in Scarpa's triangle. 232 MEDICAL RECORD 9. Describe (a) the superior longitudinal sinus (b) the lateral sinus, (c) torcular Herophili. 10. Give the anatomy of the liver. SURGERY. 1. Give varieties of hernia; describe one operation for inguinal hernia. 2. (a) Name different kind of fractures and give differ- ential diagnosis between fracture of the neck of the femur and dislocation of hip. (b) Give treatment of the latter. 3. How would you make a diagnosis of gonorrhea? Give a bacteriological examination. 4. What is empyema? Give diagnosis, prognosis, and treatment. 5. Give symptoms, diagnosis, and treatment of intestinal obstruction. 6. How would you diagnose retention of urine? What would you do for it? 7. How would you determine that a limb is injured beyond hope in a crushing accident? 8. What are the indications for appendectomy? 9. Give the treatment of shock resulting from hemor- rhage. 10. Give contraindications to the employment of ether and chloroform? MEDICAL JURISPRUDENCE. 1. What constitutes expert testimony? 2. How would you determine that a full term dead baby was born alive? 3. How would you determine (a) that a wound was in- flicted by a blunt instrument? (b) or that it was done before or after death? 4. Differentiate between idiocy and lunacy. 5. What is paresis? Give symptoms, prognosis, and treatment. OPHTHALMOLOGY. 1. Differentiate iritis and glaucoma, giving symptoms of each. 2. Describe and give etiology of (a) phlyctenular ker- atitis, and (b) interstitial keratitis. 3. What is ophthalmia neonatorum? Give etiology and the probable results of a badly managed case. 4. Give symptoms and etiology of ciliary blepharitis. 5. Differentiate myopia and hyperopia and hypermetro- pia; give the anatomical reasons for their existence, and tell what you would recommend for the relief of each. 233 MEDICAL RECORD. PHYSIOLOGY. i. (a) Give several varieties of food, (b) Which en- zymes act on each variety? 2. (a) Describe absorption, and give the function of the lymphatics, (b) Describe the thoracic duct. 3. Give chemistry and uses of bile. 4. Describe the circulation of the blood. What forces govern it? 5. Give histology of the kidney and function of the various structures. 6. Name and give the function of each of the cranial nerves. 7. Describe and .give functions of sympathetic nervous system. 8. What are the functions of the skin ? 9. Describe the blood. 10. Describe the cardiac cycle. OBSTETRICS AND GYNECOLOGY. 1. Define presentation and position. 2. Tell exactly how you would manage a shoulder pres- entation. 3. What is mensuration? (b) How is it conducted in obstetrical cases? (c) How is it of value? 4. How would you diagnose and conduct the delivery of a hydrocephalic fetus? 5. (a) What would you suspect in antepartum hemor- rhage? (b) How confirm your diagnosis? (c) How manage the case? 6. (a) When is ventrofixation indicated? (b) What is ballottement, (c) when is it valuable and how is it per- formed ? 7. Give diagnosis of extrauterine gestation. 8. Give symptoms and pathology of carcinoma uteri. 9. Describe ovary and uterus during stages of menstru- ation. 10. (a) Give two indications for hysterectomy (b) Reasons for preferring abdominal or vaginal method. CHEMISTRY. 1. What is (a) an atom? (b) a molecule? (c) What are isomeric compounds? 2. (a) What are the symptoms of acute arsenic poison- ing? (b) What is the chemical combination of its anti- dote and how does it act? (c) Tell in detail how to detect arsenic in the stomach of a case of suspected poisoning. 3. Describe in detail a method for the quantitative esti- mation of sugar in the urine. 4. Tell in detail how to detect bile in the urine. 234 MEDICAL RECORD. 5. (a) Contrast dairy milk with human milk, and (b) give a brief description of the essentials for the production of pure dairy milk. 6. What is (a) H 2 S0 4 , (b) Ba0 2 , (c) HC1, (d) HNOs? (e) What is the formula for methyl alcohol? 7. (a) What is acetphenetidin? (b) hexamethylene- tetr- amine? (c) From what are they prepared? 8. (a) Describe oxygen, (b) Give its formula, (c) val- ency, (d) atomic weight, (e) Tell how to prepare it, and give formula of your method. 9. (a) What is specific gravity? (b) How obtained for solids, (c) liquids, (d) gases? 10. Describe the chemical changes in starch during di- gestion in detail, giving formulas. NERVOUS DISEASES. 1. Give etiology of migraine. 2. Give etiology and symptoms of sciatica. 3. Describe (a) epilepsy, (b) catalepsy. 4. Describe a case of progressive bulbar paralysis. 5. Differentiate between (a) illusions, (b) delusions, (c) hallucinations. PREVENTIVE MEDICINE. 1. How long after recovery would you keep in quaran- tine a case of (a) diphtheria, (b) scarlet fever, (c) small- pox? 2. Name the portals of entry of tubercular infection in the order of their importance. 3. Describe in detail just how you would manage cases of typhoid fever for the protection of the community. 4. How would you disinfect a room after a communi- cable disease? 5. What is the difference between contagion and in- fection ? PRACTICE. 1. Define constipation; give etiology, diagnosis, and prognosis. 2. Define vertigo; give varieties and diagnosis. 3. Define myxedema ; give etiology, diagnosis, and prog- nosis. 4. Define hydrothorax ; give etiology, diagnosis and prognosis. 5. Define angina pectoris ; give etiology, diagnosis, and prognosis. 6. Define asthma ; give etiology, diagnosis, and prognosis. 7. Define adenoids ; give etiology, symptoms, and dan- gers. 235 MEDICAL RECORD 8. Define enterocolitis in a child; give etiology, diag- nosis, and prognosis. 9. Give essentials for the production and preservation of pure dairy milk. 10. Give etiology, diagnosis, and prognosis of menin- gitis in a child. OTOLOGY. 1. What is Politzer's method of inflating the tympanum, and how is it accomplished? 2. Define tinnitus aurium, and give the cause of it. 3. Give etiology, symptoms, and diagnosis of acute otitis media. 4. What is the pyramid of light, and where would you expect to find it? 5. Give symptoms, etiology, and probable serious re- sults of mastoiditis. BACTERIOLOGY. 1. Tell in detail (a) how you would detect malarial organisms in bloo~d, (b) how distinguish between the quar- tan and estivoautumnal parasite. 2. Describe (a) Widal's test for typhoid fever; (b) what is its diagnostic value? 3. Differentiate between the culture of ^ Bacillus ty- phosus and that of the Bacillus coli communis. 4. How would you examine a suspected specimen of sputum for tubercle bacilli? Give details. 5. Define (a) toxins, (b) antitoxins, (c) amboceptors, (d) bacterioproteins, (e) lysins. 6. Give the morphology of the tetanus bacillus; what are its toxins? 7. Tell in detail how to examine a suspected urethral discharge for gonococci. 8. Discuss Ehrlich's side-chain theory of immunity. 9. Differentiate between the pneumococcus and Pfeif- fer's bacillus of influenza. 10. What is phagocytosis? What is accomplished by it? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. State Board Of Health of Kentucky. anatomy. 1. See Cunningham's "Anatomy" (1909), pages 362, 376, and 357; or Gray's "Anatomy" (1908), pages 522, 537, and 518. 2. See Cunningham's "Anatomy" (1909), page 1124; or Gray's "Anatomy" (1908), page 1355. 3. The structures to be divided in operating for strangu- 236 MEDICAL RECORD. lation of an oblique inguinal hernia are : Skin, superficial fascia, intercolumnar fascia, Cremaster muscle and fascia, infundibuliform fascia, subserous areolar tissue, and peri- toneum. 4. Differences between the fourth cervical vertebra and the fourth dorsal vertebra : The fourth cervical vertebra has a small, transversely elongated body, with no facets for ribs ; the laminae are long and slender ; the spinous proc- ess is short, nearly horizontal, and bifid; the transverse processes are short and contain a foramen for the vertebral artery; the superior articular process is directed upward and slightly backward; the inferior articular process is di- rected downward and slightly forward ; the spinal foramen is large and triangular. The fourth dorsal vertebra has a heart-shaped body with a facet on each side for articulation with a rib; the lam- inae are broad and deep; the spinous process is long and points downward ; the transverse processes are long, artic- ulate with the tubercle of a rib, and do not contain a fora- men; the superior articular process is directed backward and slightly outward; the inferior articular process is di- rected forward and slightly inward; the spinal foramen is smaller and circular. 5. The axilla is bounded: Anteriorly, by the clavicle, Subclavius, Pectoralis major, costocoracoid membrane, Pec- toralis minor ; posteriorly, by the Subscapulars, Teres major, and Latissimus dorsi; internally, by the first four ribs, first three Intercostal muscles, Serratus magnus ; ex- ternally, by the humerus, Coracobrachialis, and Biceps. "Contents: The axillary vessels and brachial plexus of nerves, with their branches, some branches of the inter- costal nerves, and a large number of lymphatic glands, all connected together by a quantity of fat and loose areolar tissue. Their position : The axillary artery and vein, with the brachial plexus of nerves, extend obliquely along the outer boundary of the axillary space, from its apex to its base, and are placed much nearer the anterior than the posterior wall, the vein lying to the inner or thoracic side of the artery and partially concealing it. At the fore part of the axillary space, in contact with the pectoral muscles, are the thoracic branches of the axillary artery, and along the anterior margin of the axilla the long thoracic artery extends to the side of the chest. At the back part, in con- tact with the lower margin of the subscapularis muscle, are the subscapular vessels and nerves ; winding around the lower border of this muscle is the dorsalis scapulas artery and veins ; and toward the outer extremity of the muscle the posterior circumflex vessels and the circumflex nerve are seen curving backward to the shoulder. 237 MEDICAL RECORD. "Along the inner or thoracic side . . . are some important nerves, viz., the posterior thoracic or external respiratory nerve, descending on the surface of the serratus magnus, to which it is distributed ; and perforating the upper and anterior part of this wall, the intercostohumeral nerve or nerves, passing across the axilla to the inner side of the arm." (Gray's Anatomy.) 6. In a cross section of the thigh, at the junction of the middle and lower thirds there are severed : Muscles, Vas- tus internus, Rectus femoris, Crureus, Vastus externus, Bi- ceps, Semitendinosus, Semimembranosus, Gracitis, Sartor- ius, Adductor magnus ; Nerves, sciatic, long saphenous ; Arteries, superficial femoral, anastomotic, deep femoral, perforating. 7. (a) See Cunningham's "Anatomv" (1909), page 836; or Gray's "Anatomy" (1908), pages 660 and 666. (b) See Cunningham's "Anatomy" (1909), page 830; or Gray's "Anatomy" (1908), page 654. 8. Scarpa's triangle is a triangular area or depression situated just below the fold of the groin. It is bounded above by Poupart's ligament, externally by the Sartorius, and internally by the inner margin of the Adductor longus ; its apex is formed by the junction of the Adductor longus and Sartorius. The floor is formed, from without inward, by the Iliacus, Psoas, Pectineus, Adductor brevis, and Ad- ductor longus. Contents: The femoral vessels pass from about the center of the base to the apex, the artery being on the outer side of the vein ; the artery gives off the su- perficial and profunda branches, and the vein receives the deep femoral and internal saphenous ; the anterior crural nerve lies to the outer side of the femoral artery; the ex- ternal cutaneous nerve is still further external, lying in the outer corner of the space; just to the outer side of the femoral artery, and in the sheath with it, is the crural branch of the genitocrural nerve. At the apex, the vein (which at the base was internal to the artery) lies behind the artery. The triangle also contains fat and lymphatics. 9. (a) See Cunningham's "Anatomy" (1909), page 884; or Gray's "Anatomy" (1908), page 736. (b) See Cunningham's "Anatomy" (1909), page 886; or Gray's "Anatoirly" (1908), page 738. (c) See Cunningham's "Anatomy" (1909), page 884; or Gray's "Anatomy" (1908), page jv. 10. See Cunningham's "Anatomy" (1909), page 1108; or Gray's "Anatomy" (1908), page 1334. SURGERY. 1. Varieties of Hernia: Hernia may be classified: I. Anatomically: 238 MEDICAL RECORD i. Inguinal 2. Femoral 3. Umbilical Oblique Direct Acquired Congenital Infantile or encysted External Internal Intraparietal •j Interparietal I E* Interstitial L Extraparietal [Incomplete, or Bubonocele.] Congenital Of infants Of adults 4. Ventral. 5. Lumbar. 6. Obturator. 7. Diaphragmatic, 8. Pudendal, etc. II. Clinically : Reducible irreducible, obstructed or incar- cerated, inflamed, and strangulated. 2. (a) Fractures are variously classified: I. Simple, compound, and complicated. II. Complete (transverse, oblique, spiral, longitudinal) and incomplete (fissured, greenstick). III. Single, and multiple. IV. Comminuted, impacted, etc. V. Intra- and extra-articular; intra- and extracapsular. In fracture of the neck of the femur, the head of the femur will be found in the acetabulum; in dislocation, the acetabulum will be empty, and the head of the femur will be found elsewhere, e.g. on the dorsum of the ilium. In the fracture, crepitus may be elicited; in the dislocation, never. In the dislocation, there is inversion and a fixed position of the limb, both of which are absent in fracture. 3. The diagnosis of gonorrhea is made by finding gono- cocci within the leucocytes in a urethral discharge. For de- tails, see below — Bacteriology, Number 7. 4. See Rose and Carless' "Surgery'' (1908), page 926; or Da Costa's "Surgery" (1908), page 773. 5- Strangulation. Subjective Symptoms 1. Generally occurs af- ter age of 20. 2. Pain localized, rapid collapse. 3. Pain intense, par- oxysmal in charac- ter. 4. Constipation com- plete. Intussusception. Subjective Symptoms 1. Most frequent in childhood. 2. Constant tenesmus. 3. Pain develops sud- denly and is con- tinuous. 4. Frequent diarrhea, passage of bloody mucus. Twists (Volvulus) Subjective Symptoms 1. Most frequent after age of 30. 2. Pain diffuse. 3. Pain paroxysmal ; re- curs less often than in strangulation. 4. Constipation com- plete. 239 MEDICAL RECORD Strangulation. Objec tiv e Sy mp t oms i. Temperature often subnormal. 2. Pulse very weak. 3. Stercoraceous vom- iting comes on early 4. Location in small in- testine. Intussusception. Objective Symptoms 1. Temperature normal or subnormal. 2. Same as in strang- ulation. 3. Same as in strang- ulation. 4. Localization in small intestine ifoowel fre- quently protrudes at rectum. Twists (Volvulus) Objective Symptoms 1. Temperature slight- ly elevated. 2. Same as in strangu- lation. 3. Samje as in, stranjgu* lation. 4. Location, small in- testine ; abdomen of- ten protrudes, in cer- tain areas, giving dullness on percus- sion. And see Rose and Carless' "Surgery" (1908), pages mi and 1115; or Da Costa's "Surgery" (1908), pages 838 and 841. 6. See Rose and Carless' "Surgery" (1908), pages 1202 and 1244; or Da Costa's "Surgery" (1908), page 1125. 7. A limb may be said to be injured beyond hope in a crushing accident: (1) When it is pulpefied; (2) when the main artery or vein or both are severed and the collateral circulation is also interfered with ; (3) when very extensive cellulitis or gangrene appears within a short time of the accident; (4) when there is extensive laceration of tissues and extensive comminution of the bone. 8. The indications for appendectomy vary according to the views of the surgeon. Some maintain that every case of appendicitis should be operated on as soon as the diagnosis is made. Others would operate only in case of rupture, or when suppuration occurs, or in cases which do not improve in a week or so, or in cases which are steadily getting worse. Probably all would agree in taking out every ap- pendix that has undergone more than one mild attack. 9. See Rose and Carless' "Surgery" (1908), page 260; or Da Costa's "Surgery" (1908), page 242. 10. The following contraindications for ether and chlo- roform are from Hare's Practical Therapeutics: "Ether should not be used by inhalation in bronchitis or acute nephritis, because of its irritant properties; in peritonitis or gastritis, because it is apt to induce vomiting; in aneur- ysm or in the presence of marked vascular atheroma, be- cause it may rupture a blood-vessel by raising arterial pressure; nor in diabetes, lest it produce diabetic coma; and if anemia is present and an examination of the blood shows that the hemoglobin is below 50 per cent, the use of the drug should be avoided if possible. "Chloroform, is not to be used in cases of fatty heart or dilatation of the heart, in those with a known idiosyncrasy, nor in the so-called lymphatic persons with overgrowth of lymphoid tissues, as, for example, adenoids. In the latter 240 MEDICAL RECORD. case it is particularly apt to cause sudden death. In valvu- lar disease of the heart chloroform may be used with caution, although ether is preferable. Given a case of valvular disease that must be subjected to operation, the chances are bettered with an anesthetic than without it, as the pain and mental shock are worse for the heart than is the anesthetic." MEDICAL JURISPRUDENCE. i. In expert testimony the witness may give his opinion on facts or supposed facts as noted by himself or asserted by others. Theoretically, this can only be done by those perfectly familiar with the subject in question; but prac- tically any (or almost any) physician with a license to practise is accepted as an expert witness. 2. If respiration has taken place, its lungs will float on being put into water ; if respiration has not taken place, the lungs will sink. Further, the lungs before respiration are situated at the back of the thorax and do not fill the cavity; whereas, after respiration, they fill the whole cavity. 3. (a) A wound inflicted by a blunt instrument will have somewhat of the appearance of a contused wound; the edges will not be so clean cut, and the surrounding tissues will be more or less bruised. (b) A wound inflicted during life is generally charac- terized by hemorrhage, coagulation of the blood, eversion of the edges, and retraction of its sides. It may also be in- ferred that the wound was inflicted during life if any of the following are noticed : The presence of inflammation, swelling, pus or gangrene on the edges of the wound, or if there is any sign of beginning cicatrization. 4. "Idiocy differs from other states of insanity in the fact that it is marked by a congenital deficiency of the men- tal faculties. There is not here a perversion or a loss of what has once been acquired, but a state in which, from defective structure of the brain, the individual has never been able to acquire any degree of intellectual power to fit him for his social position. It commences with life and continues through it." (Taylor's Medical Jurisprudence.) 5. See French's "Practice of Medicine" (1907), page 1092. OPHTHALMOLOGY. I. — V Age _ Tension . . Secretion . Congestion GLAUCOMA. IRITIS. Over forty. Plus. None, or watery. General, especially scleral. Any. Normal. None, or watery. General, especially circumcorneal. 241 MEDICAL RECORD Cornea Anterior chamber.. Iris Pupil Pain Vision Treatment GLAUCOMA. Cloudy and steamy ^ surface. Shallow. Discolored. Dilated, oval. Severe, contin- uous. Much reduced. Eserine, pilocar- pine, iridectomy. IRITIS. Cloudy. Unchanged. Discolored. Contracted, syn- echias. Especially at night. Somewhat re- duced. Atropine. (From Ailing and Griffin's Diseases of the Eye and Ear.) v 2. (a) Phlyctenular keratitis "is usually associated with phlyctenular conjunctivitis in cnildren of scrofulous dia- thesis, but may occur in others. It is characterized by one or more small cysts found on the limbus of the conjunctiva and extending upon the cornea. The symptoms are acute pain, photophobia, lacrimation, and the characteristic bundle of vessels, with a yellow crescent at the apex, its concavity toward the apex. Blepharospasm is present and may be severe. " (b) Interstitial keratitis. — "Deep inflammation of the cornea. The whole cornea becomes more or less opaque and has a ground-glass appearance. Pericorneal injection is present. Inflammations of the iris, ciliary body, and cho- roid occur as complications. The affection is due to some constitutional disease, usually hereditary syphilis, but some- times tuberculosis. The condition is of long duration and results in reduction of visual acuity. Pain, lacrymation, and photophobia appear as subjective symptoms. " — (Gould and Pyle's Pocket Cyclopedia.) 3. Ophthalmia neonatorum is an infectious, purulent inflammation of the conjunctiva in the newborn, due to the gonococcus or other pyogenic germ; produced by contact of the eye with the vaginal secretion of the mother during labor, or infected fingers, or instruments, etc. The prob- able results of a badly managed case are: Ulceration and sloughing of the cornea, perforation of the anterior cham- / ber, and blindness. ^ 4. Ciliary blepharitis. Symptoms: "In the superficial or non-ulcerative form the margins of the lids are swollen and reddened, and present numerous whitish scales at the bases of the lashes. The latter fall out readily, but are replaced, since there is no destruction of the hair follicles. In the deep or ulcerative form the edges^ of the lids are reddened and swollen, and present yellowish crusts which 242 MEDICAL RECORD. glue the lashes together. On removing these crusts small ulcers are seen about the attachments of the lashes; these ulcers bleed readily. The lashes become distorted, fall out, and grow scarce, since they are not replaced on account of destruction of the hair follicles. In both forms there will be itching, soreness, epiphora, and sensitiveness to light." Etiology: "Poor hygienic surroundings; debilitated con- ditions of the system ; following the exanthemata, espe- cially measles; exposure to irritating atmosphere — smoke, wind, dust ; late hours ; insufficient sleep ; uncorrected errors of refraction, especially hyperopia and astigmatism ; chronic conjunctivitis; lachrymal disorders; lack of clean- liness. The disease occurs at all ages, but is very common in children." — (May's Diseases of the Eye.) v 5. Myopia is a condition in which the eye is practically too long, and therefore parallel rays are brought to a focus in front of the retina. Treatment: Concave lenses. Hypermetropics or Hyperopia is a condition in which the eye is practically too short, and therefore parallel rays are brought to a focus behind the retina. Treatment: Convex lenses. PHYSIOLOGY. 1. (a) Foods are classified as follows: I. Inorganic { ££*■ f Non-nitrogenous f Carbohydrates. II. Organic -j \ Fats. [ Nitrogenous — Proteids. (b) Carbohydrates are acted on by ptyalin and amylopsin, fats by steapsin, and proteids by pepsin and trypsin. 2. Absorption is the process by which the products of digestion are taken into the blood current. The nroducts of digestion find their way into the blood by two routes : (1) By the blood-vessels of the gastrointestinal tract, which unite to form the portal vein, and (2) by the lymph vessels of the small intestine, which converge to empty int© the thoracic duct. The water, inorganic salts, pro- teids, and sugar go by way of the portal vein to the ascend- ing vena cava ; the fats go by way of the thoracic duct to the junction of the left subclavian and internal jugular veins. The function of the lymphatic system is to provide the tissues with material necessary to their functional activity, growth, and repair ; to receive from the tissues their waste products ; and to convey the products of digestion and absorption to the blood current. For thoracic duct see Cunningham's "Anatomy" (1909), page 906; or Gray's "Anatomy" (1908), page 775. 243 MEDICAL RECORD. 3. The constituents of the bile may be shown in the fol- lowing table, which presents the averages of three analyses given by Hammarsten; the results are given in parts per thousand : Water " 971.380 Solids 28-620 Mucin and pigments 4*9 10 Bile salts 12,197 Taurocholate 2.431 Glycocholate 9.766 Fatty acids from soaps 1,200 Cholesterin 1,243 Lecithin and fats 0.970 Soluble salts 7.360 Insoluble salts , . . 0.317 The functions of the bile are: (1) To assist in the emulsification and saponification of fats ; (2) to aid in the absorption of fats; (3) to stimulate the cells of the intestine to increased secretory activity, and so promote peristalsis; and at the same time tend to keep the feces moist; (4) to eliminate waste products of metabolism, such as lecithin and cholesterin; (5) it has a slight action in converting starch into sugar; (6) it neutralizes the acid chyme from the stomach, and thus inhibits peptic diges- tion; (7) it has a very feeble antiseptic action. 4. The circulation of the blood is regulated in (a) the arteries by: (1) The elasticity and tone of the arteries, (2) the force and frequency of the cardiac contractions, (3) the resistance in the capillaries ; (b) in the capillaries it is regulated by (1) the action of the heart, (2) the action of the arteries: (c) in the veins it is regulated by (1) the action of the heart, (2) aspiration of the thorax, (3) the contraction of the muscles, and (4) slightly by the valves in the veins. 5. See Cunningham's "Anatomy" (1909), page 1139; or Gray's "Anatomy" (1908), page 1423. 6. See Cunningham's "Anatomy" U909), page 674; or Gray's "Anatomy" (1908), page 1036. 7. "The sympathetic nervous system consists of (1) a series of ganglia connected together by a great ganglionic cord, the gangliated cord, extending from the base of the skull to the coccyx, one gangliated cord on each side of the middle line of the body, partly in front and partly on each side of the vertebral column ; (2) of three great gangliated plexuses or aggregations of nerves and ganglia, situated m front of the spine in the thoracic, abdominal, and pelvic cavities respectively; (3) of smaller or terminal ganglia, situated in relation with the abdominal viscera; and (4) of numerous fibers." (Gray's Anatomy.) 244 MEDICAL RECORD, Its functions: "It may safely be said that the sympa- thetic system has, to a great extent, a controlling influ- ence over the secretion of most of the glands, the lacry- mal, the salivary, the sweat glands, the glands of the stom- ach and intestines, the liver, the kidney, etc.; that it pre- sides over the circulation by regulating the caliber of the blood-vessels and the action of the heart; that it influences respiration; and, finally, that all involuntary muscles, those of the digestive apparatus, of the genitourinary system, of the hair follicles (pilomotor nerves), are under its control to such extent that, for instance, in certain mammalians the bladder still continues to fulfill its function for weeks after all the cerebrospinal motor nerves leading to it have been severed. In short, we find that all vegetative life of the organism is, to a greater or less extent, under the con- trol of the sympathetic system. Therefore it may prop- erly be called the vegetative nerve system par excellence/' (Reference Handbook of the Medical Sciences.) 8. The functions of the skin are : Protection, excretion, secretion, regulation of the body temperature, absorption, sensation, special sense of touch, respiration. 9. The physical properties of blood: Fluid, somewhat viscid, red; specific gravity, from 1055 to 1062; alkaline re- action; saltish taste; characteristic odor; variable tempera- ture (average, about ioo° F.). The constituents of the blood are plasma and corpuscles. The plasma consists of water and solids (proteids, extract- ives, and inorganic salts). The red corpuscles consist of water and solids (hemoglobin, proteids, fat, and inorganic salts). The white corpuscles consist of water and solids (proteid, leuconuclein, lecithin, histon, etc.). The red blood corpuscles are biconcave discs, about 1-3200 of an inch in diameter; they are non-nucleated, and there are about 4.500,000 or 5,000,000 of them in each cubic millimeter of blood. They are elastic and soft, and their shape is changed by pressure, but is promptly regained on the removal of the pressure. Their color is yellowish. They contain hemoglobin. Their function is to carry oxygen from the lungs to the tissues. The white blood cells are spheroidal masses, varying in size, having no cell wall, and containing one or more nuclei ; there are about 7,000 to 10,000 of them in each cubic millimeter of blood. They differ much in appearance, and are divided into (1) small mononuclear leucocytes, or lymphocytes, (2) large mononuclear, (3) transitional, (4) polynuclear, or polymorphonuclear, or neutrophile, and (5) eosinophile. They are all more or less granular, par- ticularly the last two varieties named. They are probably formed in the spleen, lymphatic glands, and lymphoid tis- 245 MEDICAL RECORD. sues. Their fate is uncertain ; it has been asserted that they are converted into red blood cells; they play a part in the formation of fibrin ferment; they are sometimes con- verted into pus cells. Their functions are (i) to serve as a protection to the body from the incursions of pathogenic microorganisms ; (2) they take some part in the process of the coagulation of the blood; (3) they aid in the absorp- tion of fats and peptones from the intestine, and (4) they help to maintain the proper proteid content of the blood plasma. There are also platelets, which are very small, colorless, irregular shaped bodies; they are about one-fourth the diameter of a red corpuscle. Their function is not deter- mined ; it is possible that they take some part in the coagu- lation of the blood. In number they vary from about 200,000 to more than 500,000 in each cubic millimeter of blood. Plasma conveys nutriment to the tissue; it holds in solu- tion the carbon dioxide and water which it receives from the tissues, and takes them to be eliminated by the lungs, kidneys, and skin; it also holds in solution urea and other nitrogenous substances that are taken to and excreted by the liver or kidneys. 10. The cardiac cycle includes all the changes which occur between the commencement of one heart-beat and the com- mencement of the next ; it consists of the alternate contrac- tions (or systole) and relaxations (or diastole) of the auricles and ventricles of the heart. The contraction of the two auricles takes place simultaneously, and is followed by the simultaneous contraction of the two ventricles; then follows a period during which the whole heart is in a state of diastole. The cycle then begins again with the auricular systole. OBSTETRICS AND GYNECOLOGY. i. By presentation is meant the part of the fetus which presents at the pelvic brim ; examples — vertex, breech, face. By position is meant the relation between a point on the fetus and a point on the maternal pelvis; examples — in a vertex presentation the position may be (1) left occipito- anterior, (2) right occipito-posterior, (3) right occipito- anterior, (4) left occipito-posterior. 2. In cases of shoulder presentation, if seen before labor, version should be performed to correct the mal-presenta- tion; in case of impaction a Cesarean section is indicated; sometimes decapitation or embryotomy has been performed, but a Cesarean section is preferable. Cases of shoulder presentation have been known to terminate spontaneously, but it is not advisable to rely on this possibility. 3. Mensuration is measuring (the pelvis) ; the same as 246 MEDICAL RECORD. pelvimetry. See Williams' ''Obstetrics" (1909), page 683; or Hirst's "Obstetrics" (1909), page 448. 4. See Williams' "Obstetrics" (1909), page 795; or Hirst's "Obstetrics" (1909), page 561. 5. (a) Placenta previa, or premature separation of a normally situated placenta. (b) and (c) See Williams' "Obstetrics" (1909), pages 814 and 815; or Hirst's "Obstetrics" (1909)* page 577. 6. (a) Ventrofixation is indicated in cases of: Retroflexed uterus, prolapsed uterus. (b) and (c) See Williams' "Obstetrics" (1909), page 183; or Hirst's "Obstetrics" (1909), page 203. 7. "When extrauterine pregnancy exists there are: (1) The general and reflex symptoms of pregnancy; they have often come on after an uncertain period of sterility. Nau- sea and vomiting appear aggravated. (2) Then comes a disordered menstruation, especially metrorrhagia, accom- panied with gushes of blood, and with pelvic pain coinci- dent with the above symptoms of pregnancy. Pains are often very severe, with marked tenderness within the pel- vis. Such symptoms are highly suggestive. (3) There is the presence of a pelvic tumor characterized as a tense cyst, sensitive to the touch, actively pulsating. This tumor has a steady and progressive growth. In the first two months it has the size of a pigeon's egg; in the third month it has the size of a hen's egg] in the fourth month it has the size of two fists. (4) The os uteri is patulous ; the uterus is displaced, but is slightly enlarged and empty. (5) Symp- toms No. 2 may be absent until the end of the third month, when suddenly they become severe, with spasmodic pains, followed by the general symptoms of collapse. (6) Expul- sion of the decidua, in part or whole. Nos. 1 and 2 are presumptive signs; Nos. 3 and 4 are probable signs; Nos. 5 and 6 are positive signs." (American Text-Book of Ob- stetrics.) 8. See Rose and Carless' "Surgery" (1908), page 1285. 9. See Williams' "Obstetrics" (1909), pages 81 and 85; or Hirst's "Obstetrics" (1909), pages 58 and 61. 10. (a) Two indications for hysterectomy: Carcinoma and fibroids. (b) As to preference between the vaginal and abdominal routes, the following is taken from Garrigues' Gyne- cology: "If the vaginal route is available, it should be preferred, because it entails much less shock, requires a simple after-treatment, does not leave any visible cicatrix, predisposes less to hernia, and allows the patient to re- sume work in shorter time. On the other hand, the vag- inal route is more difficult on account of the limited space. Hemorrhage is more troublesome to check, adhesions are 247 MEDICAL RECORD. harder to separate, and the bladder and intestine more ex- posed to injury and less accessible for repair. The pelvic cavity cannot be seen so well and the abdominal not at all. If tissue is left to mortify, it emits an offensive odor." CHEMISTRY. i. (a) An atom is the smallest portion of an element that can enter into a chemical reaction, or that can enter into the composition of a molecule. (b) A molecule is the smallest quantity of any substance that can exist in a free state. (c) Isomeric compounds are compounds which, while differing in properties, possess the same percentage com- position. 2. (a) The symptoms of acute arsenical poisoning: "In acute cases the symptoms usually begin in from twenty to forty-five minutes. Nausea and faintness. Violent, burn- ing pain in the stomach, which becomes more and more intense, and increases on pressure. Persisting and distressing vomiting of matters, sometimes brown or gray, or streaked with blood, or green (Paris green). Purging. More or less severe cramps in the lower extremities." (Witthaus' Essentials of Chemistry.) (b) The chemical antidote is freshly prepared ferric hydroxide. The ferric hydroxide changes the arsenic into ferrous arsenate, which is nonpoisonous. The reaction is represented by the following equation: As 2 3 +2Fe 2 (OH) 6 =:Fe(OH)2+sH 2 0+Fe3(As0 4 ) 2 . (c) Test for arsenic: Reinsch's test is as follows: To the suspected fluid add a little pure HC1; suspend in the fluid a small strip of bright copper foil, and boil. If a de- posit forms on the copper, remove the copper, wash it with pure water, dry on filter paper, but be careful not to rub off the deposit. Coil up the copper, and put it into a clean, dry glass tube, open at both ends, and apply heat at the part where the copper is. If arsenic is present there will ap- pear in the cold part of the tube a mirror, which will be found on microscopical examination to consist of octa- hedral crystals of arsenic trioxide. 3. Method for the quantitative estimation of sugar in urine: (( Fehling's method. — The solution is made as fol- lows: I. Dissolve cupric sulphate 51-98 gm. in water to 500.00 c.c. II. Dissolve Rochelle salt 259.9 gm. in sodium hydroxide soln. sp. gr. 1.12 to 1,000 c.c. (Piffard). When required for use, one volume of I. is to be mixed with two volumes of II. The copper contained, in 10 c.c. 248 MEDICAL RECORD. of this mixture is precipitated completely, as cuprous oxid, by 0.05 gm. of glucose. "To determine the quantity of sugar, place 10 c.c. of the mixed soln. in a flask of about 250 c.c. capacity, dilute with H 2 to about 30 c.c, and heat to boiling. On the other hand, the urine to be tested is diluted and thoroughly mixed with four volumes of H 2 if it be poor in sugar, or with nine volumes of H 2 if highly saccharine, and a burette filled with the mixture. When the Fehling soln. boils, add a few gtt. NH 4 HO and then 5 c.c. of the urine from the burette, boil again, and continue the alternate addition of diluted urine and boiling of the mixture until the blue color is quite faint. Now add the diluted urine in quantities of 1 c.c. at a time, boiling after each addition until the blue color just disappears. Have ready a small filter, and, having filtered through it a few gtt. of the hot mixture, acidulate the filtrate with acetic acid, and add to it 1 gtt. soln. of potassium ferrocyanide. If a brownish tinge be produced, add another ^4 c.c. of dil. urine to the flask, boil, and test with ferrocyanide as before. Continue this proceeding until no brown tinge is produced. The burette reading, taken at this point, gives the number of c.c. of dilute urine containing 0.05 gm. glucose, and this divided by 5 or 10, according as the urine was diluted with 4 or 9 volumes of H 2 0, gives the number of c.c. of urine contain- ing 0.05 gm. sugar. The number of c.c. urine passed in twenty-four hours divided by 20 times the number of c.c. containing 0.05 gm. glucose, gives the elimination of glu- cose in twenty-four hours in grams. Example. Urine in 24 hours = 2,436 c.c. Fehling's soln. used = 10 c.c. Urine diluted with 4 vols. H 2 Burette reading = 18.5 c.c. 18.5 = 3-7 = c.c. urine containing 0.05 gm. glucose. 5 2,436 = 32.92 = grams glucose eliminated in 24 hours." 37X20 (Witthaus' Urinalysis.) 4. Test for bile: Put 3 c.c. HN0 3 in a test tube, add a piece of wood, and heat until the acid is yellow; cool, When cold, float some of the urine to be tested upon the surface of the acid. A green band is formed at the junc- tion of the liquids, which gradually rises, and is succeeded from below by blue, reddish-violet, and yellow. 5. (a) Dairy milk (assuming it to be pure) contains (approximately^ 4 per cent, each of proteids, fat, and sugar; whereas in human milk the proteids are about 1 to 2 per cent., the fat about 3 to 4 per cent., and the sugar about 249 MEDICAL RECORD. 6 to 7 per cent. Dairy milk may be acid in reaction and contains numerous bacteria, whereas human milk is ampho- teric or slightly alkaline and generally contains no bacteria. 6. (a) H2SO4 is the formula for a molecule of sulphuric acid; (b) Ba0 2 for one of barium dioxide; (c) HC1 for one of hydrochloric acid; (d) HNO3 for one of nitric acid, (e) The formula for methyl alcohol is H.CH 2 OH. 7. (a) Acetphenetidin (or phenacetin) is ethylpara- acetamidophenate. (b) Hexamethylene-tetramine is urotropin. (c) The former is prepared by the action of glacial acetic acid upon paraphenetidin ; the latter by the action of am- monia upon formaldehyde. 8. (a) Oxygen is a colorless, odorless, tasteless gas, slightly soluble in water, heavier than air. It has a strong tendency to combine with other elements, and forms binary compounds with all elements except fluorine and bromine. Oxygen is necessary to the processes of life and combus- tion. (b) Its symbol is O; (c) valence, two; (d) atomic weight, 16. ( e ) Oygen may be prepared by heating potassium chlorate. 2KCIO3 = 2KCI+3O2. 9. (a) Specific gravity is the weight of any substance as compared with the weight of an equal volume of another substance taken as a standard under like conditions of tem- perature and pressure. (b) Specific gravity of solids: "1. Solids Heavier than Water. — First weigh it in air and then in water. The difference is the weight of the volume of water displaced. The weight in air is divided by this figure. 2. Solids Lighter than Water. — First weigh it in air, then in water with a sinker attached. The specific weight of the sinker is then determined and subtracted from that of both. The specific gravity is calculated as before. 3. Solids Soluble in Water. — The specific gravity is de- termined in a liquid having no solvent action, the specific gravity of which is known, and the weight of a correspond- ing volume of water is calculated." (c) Of Liquids: "Weigh equal volumes of water and the given liquid and divide the latter by the former. The pyknometer is a flask of thin glass holding accurate- ly when completely filled a given volume at a definite tem- perature, and is much used for determining specific gravity of fluids. The hydrometer is an instrument used for this purpose, also, and is generally made of glass tubing^ weighted below to maintain it upright when floating^ and with a stem above showing a scale. One form sinks in water to a mark on 250 MEDICAL RECORD. the scale — usually i — and the other marks show at once the specific gravity of the fluid, according as the instrument floats above or below or at this level." — (McGlannan.) (d) Of Gases: By the specific gravity bottle; or divide the weight of its molecule by two. 10. The ptyalin of the saliva and the amylopsin of the pancreatic juice act upon boiled starch, and by hydrolysis convert it into soluble starch. By further hydrolytic cleav- age, maltose, erythrodextrin, and achroodextrin are formed. "According to Brown and Heron the reactions may be represented thus : One molecule of gelatinous starch is converted by the action of an amylolytic ferment into n molecules of soluble starch. One molecule of soluble starch=io(Ci 2 H»Oio)+8(H 2 0), which is further converted by the ferment into i. Erythrodextrin + Maltose. 9(Cl2H2oOlo) (O2H22O11) then into 2. Erythrodextrin -f- Maltose. 8(CuH»Oio) 2(Ci.H*0u) next into 3. Achroodextrin + Maltose. 7(GsH*Oio) 3(Ci«H»Qn) And so on ; the resultant being : io(GtH»Oio)+8(H,0)=8(C«HaOn)+ 2(CttH»0i«) ." Soluble starch Water Maltose Achroodextrin. (From Kirkes' Physiology.) NERVOUS DISEASES. 1. Etiology of migraine : Heredity, female sex, and age (about the time of puberty) are all predisposing factors; neurotic family history, epilepsy, and hysteria also predis- pose; overwork at school in conjunction with lowered phy- sical health, eyestrain, injury, shock, fatigue, gout, rheuma- tism, indigestion, and autotoxemia may all cause migraine. 2. See French's "Practice of Medicine" (1907), page 997; or Osier's "Practice of Medicine" (1909), page 1039. 3. (a) See French's "Practice of Medicine" (1907), page 1 125; or Osier's "Practice of Medicine" (1909), page 1058. (b) Catalepsy: "A peculiar neurosis characterized by loss of will and muscular rigidity, due to a diseased condition of the central nervous system. It is seen in neurotic indi- viduals between 20 and 30 years, and is commonly asso- ciated with hysteria. It occurs suddenly in paroxysms and usually with loss of consciousness. During the attack ex- ternal stimulation is necessary. Faradization and emetics are also of value. In the interval the neurotic condition 251 MEDICAL RECORD. should receive attention," — (Gould and Pyle's Pocket Cy- clopedia.) 4. See French's "Practice of Medicine" (1907), page 1044; or Osier's "Practice of Medicine" (1909), page 901. 5. A delusion is a belief in something which has no real existence, but is purely imaginary; and out of which the person cannot be reasoned. An illusion is a false or per- verted impression, received through one of the senses. An hallucination is the same as an illusion, but without any material basis. If an individual believes himself to be made of glass, and is afraid of being touched lest he be broken, he is suffering from a delusion. If the whistling of the wind is mistaken for a voice telling' a person to do a certain thing — that would be an illusion. If a person fancied he heard a voice when there was nothing at all to be heard, that would be an hallucination. PREVENTIVE MEDICINE. i. (a) Diphtheria: About four weeks; but all discharges must have ceased, there must be no albumin in the urine, and bacteriological examination of nose and throat must be repeatedly negative. (fr) Scarlet fever: About six weeks; when all desquama- tion, discharge from ears or nose, albuminuria, and sore throat shall have disappeared. (c) Smallpox: About six weeks from the beginning; one week after every scab has disappeared. 2. Air-passages, mouth (with food and drink), wounds in skin and mucous membranes. 3. See French's "Practice of Medicine" (1907), page 108; or Osier's "Practice of Medicine" (1909), page 96. 4. See French's "Practice of Medicine" (1907), page 309. 5. A contagion is an infectious disease in which the causa- tive microorganism is readily communicable from person to person by mediate or immediate contact. An infection is a disease due to a microorganism. PRACTICE. 1. See French's "Practice of Medicine" (1907), page 805; or Osier's "Practice of Medicine" (1909), page 525. 2. Vertigo is a disturbance of the sense of equilibrium, a condition in which the patient or objects surrounding him appear to be in a state of rotation or oscillation. It is not a disease ; but is a symptom of many pathological condi- tions. The chief varieties are: (1) Auditory, or labyrinthine, also called Meniere's disease; (2) cerebral; (3) gastric; (4) toxic; (5) senile; (6) hysterical; (7) essential. 252 MEDICAL RECORD. The diagnosis is based on the histdy of the case, the etiology and the absence of unconsciousness and of convul- sive movements. It is to be differentiated from epilepsy, in which the patient is unconscious and also has convulsive movements. 3. See French's "Practice of Medicine" (1907), page 552; or Osier's "Practice of Medicine" (1909), page 768. 4. See French's "Practice of Medicine" (1907), page 702. 5. See French's "Practice of Medicine" (1907), page 618; or Osier's "Practice of Medicine" (1909), page 839. 6. See French's "Practice of Medicine" (1907), page 658; or Osier's "Practice of Medicine" (1909), page 609. 7. Adenoids are hypertrophied adenoid tissue in the nasopharynx. Causes : The real cause is unknown, but the condition is generally observed in childhood; heredity is also sup- posed to be a factor; males are more frequently affected than females ; malnutrition and scrofula seem to be causa- tive factors ; the condition is often associated with enlarged tonsils, enlarged cervical glands, hypertrophy of the nasal mucous membrane, deviations of the septum, spurs ; it often follows some of the acute infectious diseases. Symptoms: Mouth-breathing; snoring; open-mouth; a vacant, dull expression of the face; modification of the voice (nasal twang), with inability to pronounce certain letters. Effects : Earache and other ear affections ; mental de- ficiency; frequent attacks of coryza; nose-bleed; stunted growth ; convulsions, laryngismus stridulus, and various other neuroses may also be noticed. 8. See French's "Practice of Medicine" (1907), page 784; or Osier's "Practice of Medicine" (1909), page 508. 9. Essentials for the production and preservation of pure dairy milk: Vaughan's rules are as follows: "(1) The cows should be healthy, and the milk of any animal which seems indisposed should not be mixed with that from the healthy animals. (2) Cows must not be fed upon swill or the refuse from breweries or glucose factories,, or upon any other fermented food. (3) Milch cows must not be allowed to drink from stagnant pools, but must have access to fresh, pure water. (4) The pasture must be freed from noxious weeds, and the barn and yard must be kept clean. (5) The udders should be washed and then wiped dry before each milking. (6) The milk must be at once thoroughly cooled. This is best done in the summer by placing the milk can in a tank of cold water or ice water, the water being of the same depth as the milk in the can. It would be well if the water in the tank could be kept flowing, and this will be necessary unless ice water is used. The tank should be 253 MEDICAL RECORD. thoroughly cleaned each day to prevent bad odors. The can should remain uncovered during the cooling, and the milk should be gently stirred. The temperature should be reduced to 6o° F., or lower, within an hour. The can should remain in cold water till ready for delivery. (7) Milk should be delivered during the summer in refrigerated cars or in bottles about which ice is packed during trans- portation. (8) When received by the consumer it must be kept in a clean place, and at a temperature some degrees below 6o° F." 10. See French's "Practice of Medicine" (1907), pages 139, 146, and 148; or Osier's "Practice of Medicine" (1909), pages 158, 163, and 164. OTOLOGY. 1. The Politzer Method. — "In usin^r this mode of inflation the patient is directed to take a sip of water from a glass and retain it within the mouth until instructed by the phy- sician by word or sign to swallow. Ihe nozzle of a Politzer airbag (Fig. 51) is placed snugly into one nostril, while the other is held firmly closed. The patient then swallows at the eiven signal, and the air-bag is simultaneously com- pressed, when, if the soft palate rests tightly enough against the pharyngeal wall, the air makes its passage up the Eustachian tube into the tympanum, as may be heard by the auscultation test. Instead of employing the act of swallow- ing to close the pharyngeal space, the patient may be in- structed to forcibly pronounce the word 'hook/ prolonging the 'k' sound, or markedly distend the cheeks in an attempt at forced expiration, when the air-bag may be used as pre- viously indicated." — (Ailing and Griffin.) 2. Tinnitus aurium is the name given to any subjective sounds heard in the ear. The chief causes are: Neuras- thenia, impacted cerumen, otitis, and other ear diseases; Meniere's disease, obstruction of the Eustachian tube, anemia, leukemia, cerebral hyperemia and anemia, arterio- sclerosis, gout, digestive disorders, excessive use of alcohol or tobacco, and the use of certain drugs such as quinine or salicylic acid. 3. Acute catarrhal otitis media is frequently caused by acute coryza and the infectious fevers. There is a painless obstructed sensation in one or both ears, impairment of hearing, and tinnitus. The inflammation causes closure of the Eustachian tube. Inflation and aspiration of the middle ear and syringing and douching the nares and nasopharynx must be avoided. "Acute purulent otitis media: Acute catarrhal otitis media, instead of undergoing resolution, may pass into acute purulent otitis media (especially in exanthemas) from the passage of pathogenic germs from the nasopharynx into the middle ear. The pain will become more intense, 254 MEDICAL RECORD. the hearing dull; tinnitus will become louder and more distressing, and fever usually sets in. 4. The pyramid of light is a reflection of light from the anterior inferior quadrant of the membrana tympani. It is roughly triangular in shape, and its apex touches the tip of the manubrium of the malleus, while its base lies on or near the periphery of the membrana tympani. 5. See Rose and Carless' "Surgery" (1908), page 885. BACTERIOLOGY. 1. To determine the presence of malarial parasite: A few hours before the chill, a drop of blood should be taken from the cleansed lobe of the ear or tip of the finger of the patient. The blood should be received on the center of a cover-glass, which should then be quickly placed, blood-side down, on a slide. Search should be made with a one-twelfth oil immersion objective, and but little illu- mination. The ordinary tertian parasite appears as a small, pale, and ring-like body within the red corpuscles ; it has an active vibratile motion ; sometimes a dark pigment is present, and segmenting bodies or rosettes may be seen. See trench's "Practice of Medicine" (1907), pages 233 and 235; or Osier's "Practice of Medicine" (1909;, page 12. 2. (a) The Widal test for typhoid fever "depends upon the fact that serum from the blood of one ill with typhoid fever, mixed with a recent culture, will cause the typhoid bacilli to lose their motility and gather in groups, the whole called 'clumping/ Three drops of blood are taken from the well-washed aseptic finger tip or lobe of the ear, and each lies by itself on a sterile slide, passed through a flame and cooled just before use; this slide may be wrapped in cotton and transported for examination at the laboratory. Here one drop is mixed with a large drop of sterile water, to redissolve it. A drop from the summit of this is then mixed with six drops of fresh broth culture of the bacillus (not over twenty-four hours old) on a sterile slide. From this a small drop of mingled culture and blood is placed in the middle of a sterile cover-glass, and this is inverted over a sterile hollow-ground slide and examined. ... A positive reaction is obtained when all the bacilli present gather in one or two masses or clumps, and cease their rapid movement inside of twenty minutes." (From Thayer's Pathology.) (b) Its diagnostic value is believed by some to be great ; others place little reliance on it. It may be absent in cases of typhoid fever ; it may be present for several months after an attack of typhoid ; the reaction may not be obtained till the third week of the disease ; it may be present in other diseases or in perfectly healthy persons. The above have all been urged as objections; certainly only positive results have any value at all. 255 MEDICAL RECORD 3. The cultural and microscopic points of difference be- tween the Bacillus coli communis and the Bacillus ty- phosus (of Eberth) are: "(1) The motility of the colon bacillus is, as a rule, not very pronounced, sometimes absent; that of the typhoid bacillus is usually very active. "(2) On gelatine plates the colon bacillus develops more rapidly and luxuriantly than the typhoid bacillus, and on potato it grows more -abundantly, being almost always visible. "(3) The colon bacillus coagulates milk with acid reac- tion within twenty- four to forty-eight hours; the typhoid bacillus does not coagulate milk. "(4) The colon bacillus causes fermentation with pro- duction of gas in media containing sugar; the typhoid bacillus does not. "(5) In nutrient agar or gelatine containing lactose and litmus tincture and of a slightly alkaline reaction, the color of the colonies of colon bacillus is pink and the sur- rounding medium red; while the colonies of typhoid bacil- lus are blue and there is little or no reddening of the medium. "(6) The colon bacillus produces indol in cultures of bouillon or peptone; the typhoid bacillus does not. "(7) When a twenty-four-hour-old bouillon culture of the colon bacillus is mixed with the blood or serum of a patient suffering from genuine typhoid fever, in a dilu- tion of one to ten or more, after the first week of the dis- ease, the Widal reaction is negative; cultures of the typhoid bacillus treated in the same manner and ex- amined in the hanging drop give the characteristic ag- glutination and clumping of the bacilli." (Reference Hand- book of the Medical Sciences.) 4. The sputum must be recent, free from particles of food or other foreign matter ; select a cheesy-looking nodule and smear it on a slide, making the smear as thin as possible. Then cover it with some carbolfuchsin, and let it steam over a small flame for about two minutes, care being taken that it does not boil. Wash it thoroughly in water and then decolorize by immersing it in a solution of any dilute mineral acid for about a minute. Then make a contrast stain with solution of Loeffler's methylene blue for about a minute ; wash it again and examine with oil immer- sion lens. The tubercle bacilli will appear as thin red rods, while all other bacteria will appear blue. 5. (a) Toxins are the poisonous products of pathogenic bacteria. (b) Antitoxins are substances formed in the body, of a protective character, and capable of rendering inert the poisonous products of bacteria. 256 MEDICAL RECORD. {c) Amboceptors are antibodies having a double com- bining affinity; one linking on to the cell to be destroyed, and the other linking on to the alexin or complement. (d) Bacterio proteins are proteins contained in bacteria. ( *} Lysins are bacterial products which are capable of destroying alexins and so promote the growth of the bac- teria. 6. The bacillus of tetanus is characterized by its pecu- liar spore, formed at one end of the bacillus, and giving it the appearance of a pin; it is purely anaerobic, and cannot be developed at all in the presence of oxygen. It generally comes from the soil, and is found in penetrating wounds. It appears in two forms, the spore-bearing form, as de- scribed above, and the vegetative form, which is a short bacillus with rounded ends, and which may occur singly or in pairs, or may form long filaments. It grows in gelatin stab cultures in the middle of the medium, and the colonies look something like a fir tree; its growth is slow, and a disagreeable odor is at the same time emitted. In bouillon, it grows near the bottom of the tube, and produces gases. Its toxins, are : Tetanospasmin, tetanolysin, tetanotoxin, tetanin, and another (without a name). 7. To demonstrate gonococci in a urethral discharge: On a cover-glass make a smear with the discharge as thin as possible, and let it dry in the air ; cover it with a freshly made solution of anilin-oil-gentian-violet for one or two minutes ; wash it in distilled water ; leave it in Gram's solu- tion for two minutes ; wash it in 95 per cent, alcohol until decolorized ; wash it in distilled water ; counterstain with a dilute carbolfuchsin without heat, or with a saturated aqueous solution of Bismarck brown; wash in distilled water, dry with filter paper, mount, and examine with an oil-immersion lens. The gonococci will appear as diplo- cocci within the leucocytes, which have been decolorized by Gram's stain, and have taken the counterstain. 8. Several theories have been advanced to account for immunity, but the only two that are considered now are : (1) MetchnikofFs theory of phagocytosis and (2) Ehr- lich's side-chain theory. This latter "is based on the idea that the toxin destroys a cell by entering into chemical union with it. The molecule of toxin contains at least two groups of atoms, a toxophore group, in which the poison- ous principle resides, and a haptophore group, which brings the toxophore group into touch with the cell and through which chemical combination takes place. Similarly, the cell contains a haptophore group, but the toxophore group of the toxin can only unite with it and destroy it when its haptophore companion has affinity with that of the cell. If that affinity does not exist the two haptophore groups do not unite, the toxophore group does not come into contact 257 MEDICAL RECORD. with the cell, and the animal is immune. Such is natural immunity. If there is affinity and the cell can throw off a haptophore group (antitoxin), which in its detached con- dition unites with the haptophore group of the toxin, the toxophore group has then nothing with which it can unite and the animal is immunized. When the individual has to contend with a bacterium as well as its toxin, the same principle obtains. Immunity is established by the produc- tion of a double haptophore group, one for the bacterium, the other for its toxin." — (Stenhouse's Pathology.) 9. The pneumococcus is an encapsulated bacillus, non- motile, non-flagellated, aerobic, non-liquefying, non-sporo- genous, non-chromogenic, staining by ordinary methods, but Gram-negative: Pfeiffer's bacillus of influenza is very similar in prop- erties, but it is exceedingly small, and is not encapsulated. 10. Phagocytosis is the faculty of certain cells (notably the mononuclear and polynuclear leucocytes) to take up and destroy bacteria. It has a protective function. STATE BOARD EXAMINATION QUESTIONS. Board of Medical Examiners of Maryland. ANATOMY. 1. Bone? Composition and structure. 2. Name bones with which the temporal articulates. 3. Describe the thoracic duct. 4. Name the ductless glands. 5. Describe any one ductless gland. 6. Make diagram of transverse section of thoracic spinal cord. 7. Give general plan of circulation. 8. Describe the ophthalmic nerve. 9. Describe the middle ear. 10. Origin, insertion, action, and nerve-supply of teres major and gracilis muscles. PHYSIOLOGY. 1. (a) Define human physiology, (b) Define physiolog- ical leucocytosis and mention some conditions in which it is found, (c) Give normal blood-pressure. 2. State what you know of the composition and charac- acter of urine, and mention the most frequent abnormal constituents. 3. (a) What are the sources of oxygen and carbonic- acid gas in the system? (b) What is the effect of each upon the blood? 4. What is meant by absorption and nutrition? 258 MEDICAL RECORD. 5. Where in the body is each of the following found, and what is the function of each : Pepsin, trypsin, glyco- gen, ptyalin, and synovia? 6. Describe the normal heart sounds and factors produc- ing each. 7. Describe briefly the functions of the pneumogastric nerve. 8. Give the functions of the skin, and describe briefly how each function is performed. 9. Lymph : Origin, description, composition, and func- tions. 10. (a) Describe the normal pulse, and give the average rate during infancy, youth, and old age. (fr) What is the normal ratio of the pulse to respiration? CHEMISTRY. 1. Define (a) diffusion, (b) dialysis, (c) combustion, (d) reagents, (e) oxidation, and give an illustration of each. 2. (a) What is the reaction of normal gastric juice, (b) and to what is it due? 3. (a) Give properties, (b) chemical formula, and (c) uses of permanganate of potash. 4. Mention one chemical antidote for each of the fol- lowing: (a) Phenol, (b) arsenious oxide, (c) sulphuric acid, (d) mercuric chloride, (e) oxalic acid. 5. Complete the following equations : (a) Ba0 2 + H 2 S04 = (b) 2K1 + HgCl 2 = (c) Na 2 C0 3 + CaCl 2 = (d) Pb(N0 3 ) 2 + Na 2 S04 = (e) 2KOH -f H 2 S0 4 = 6. Describe in detail the examination of a sample of urine for the detection of sugar, albumen and bile. 7. Give (a) chemical formula, (b) properties, and (c) uses of iodoform. 8. Give a chemical classification of foodstuffs, with an example of each. g. Under what circumstances are the syllables mono, di-, tri-, tetra-, and penta- used in chemical nomenclature? Give examples. 10. Describe Marsh's test for arsenic. MATERIA MEDIC A. i. How is opium obtained? (a) What per cent, of mor- phine should the official powdered opium yield? (b) Name two alkaloids of opium and give doses. 2. Give the official name and composition of (a) Fow- ler's solution, (b) Donovan's solution. 3. Xame five official preparations of mercury. 259 MEDICAL RECORD. 4. State the dose of infusion of digitalis, fluid extract of ergot, oleum terebinthinse, sodium salicylate, and tinctura opii deodorati. 5. Give the official name and dose of (a) Epsom salts, (b) Rochelle salts, (c) Glauber salts. 6. What is incompatibility in medicine, and what are the different kinds of incompatibles ? 7. Would you write potassium chlorate and tannin in the same prescription? Give reasons for your answer. 8. Define narcotics, anesthetics, and sedatives, and give an example of each. 9. Name the four principal alkaloids of cinchona. 1 10. Mention the three principal salts of potassium used ' in medicine, and give dose of each. THERAPEUTICS. 1. Name two respiratory stimulants and two vasomotor depressants. Give doses. 2. Describe and give the indications for the use of car- diac sedatives, with an example. 3. For what purpose is diaphoresis produced? Name three diaphoretics. 4. By what methods do antipyretics act? 5. Define anthelmintics, and name some remedies of this class. 6. Explain how antitoxin produces immunity and effects cure. 7. What therapeutic uses has chloroform other than as an anesthetic? 8. What is cumulative action? Name one drug that has this tendency, and give symptoms of such action. 9. What is the important alkaloid of erythroxylon, and what is its principal therapeutic use? 10. What are the therapeutic uses of the preparations of bismuth ? PATHOLOGY. 1. Define (a) calcification, (b) neuroma and angioma, (c) a retention cyst, (d) What are the degenerative changes of arteries? (e) What is osteomalacia? 2. How does sarcoma differ histologically from car- cinoma ? 3. What pathological changes are found in Addison's disease? 4. Give pathology of tabes dorsalis. 5. Describe pathological change that takes place in the liver from chronic interstitial hepatitis or atrophic cir- rhosis. 6. What pathological changes occur in acute lobar pneu- monia? r 260 MEDICAL RECORD. 7. What is diplococcus ? Name two pathogenic diplococci. 8. Define (a) germicide, (b) antiseptic, (c) asepsis, (d) sterile, (e) disinfectant. 9. What is essential to the life of bacteria? 10. What special culture medium is required for the growth of gonococcus? PRACTICE. 1. Define (a) epidemic parotitis, (b) difference between endemic and epidemic diseases, (c) dysphagia, and name some diseases in which it occurs; (d) Koplik's sign and Kernig's sign. In what diseases do they occur? 2. What is (a) percussion, (b) inspiration, (c) men- suration, (d) palpation, (e) auscultation, (/) succussion, (g) egophony. 3. Give differential diagnosis between membranous and spasmodic croup, and give treatment of each. 4. Give differential diagnosis between varioloid and vari- cella. 5. Give differential diagnosis between hysteria and epi- lepsy. 6. Give symptoms of Graves' or Basedow's disease. 7. Give causes and symptoms of ascites, and indicate how to recognize by what disease it is produced. 8. Give treatment of erysipelas. 9. Give treatment of diabetes mellitus. 10. Describe symptoms of herpes zoster and its treat- ment. SURGERY. 1. What is an abscess, an aneurysm, and with what con- ditions may aneurysm be confounded? 2. Define peritonitis. 3. Describe operation for ligation of subclavian in its third portion. 4. Describe tonsillectomy, and how would you arrest dangerous hemorrhage after this operation? 5. Name and describe the more common errors of re- fraction. 6. Define glaucoma, and describe its surgical treatment. 7. W f here and when, if at all, should metallic sutures be used, and why? 8. Give symptoms, signs, diagnosis, and surgical treat- ment (operative and non-operative) of tuberculous coxitis (hip-joint disease). 9. Name several local anesthetics and mode of applica- tion. 10. Cholecystotomy : Indication, limitations, technicque. OBSTETRICS. 1. What are the factors concerned in normal menstru- 261 MEDICAL RECORD. ation? Under what pathological condition may menstrua- tion be absent? 2. How is external palpation applied in the diagnosis of the position of the fetus? 3. What is puerperal eclampsia? Describe the prophy- laxis and give treatment. 4. Give the causes, diagnosis, and treatment of prolapse of the cord. 5. Give the causes, diagnosis, mechanism, and manage- ment of a face presentation. 6. Mention all the structures divided in complete lacera- tion of the perineum, and describe an operation for their restoration. 7. Give the pathological anatomy, symptoms, diagnosis, and treatment of membranous dysmenorrhea. 8. Give reasons for the shortening of the round liga- ments. Describe the operation. 9. Describe the structures and development of a dermoid cyst of the ovary. 10. Give the causes of icterus of the new-born. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Board of Medical Examiners of Maryland. ANATOMY. 1. See Cunningham's "Anatomy" (1909), pages 70 and 71; or Gray's "Anatomy" (1908), pages 41 and 34. 2. The Temporal bone articulates with the Occipital, Parietal, Sphenoid, Inferior Maxillary, and Malar bones. 3. See Cunningham's "Anatomy" 1909), page 906; or Gray's "Anatomy" (1908), page 775. 4. The ductless glands are: Spleen, thyroid, parathyr- oids, thymus, suprarenale coccygeal, carotid, pineal pituit- ary, and lymphatic glands. 5. See Cunningham's "Anatomy" (1909), page 1210; or Gray's "Anatomy" (1908), page 1407. 6. See Cunningham's "Anatomy" (1909), page 458; or Gray's "Anatomy" (1908), page 843. 7. See Gray's "Anatomy" (1908), page 557. 8. See Cunningham's "Anatomy" (1909), page 679; or Gray's "Anatomy" (1908), page 1043. 9. See Cunningham's "Anatomy" (1909), page 748; or Gray's "Anatomy" (1908), page 1160. 10. Teres Major. Origin: Inferior angle of scapula. Insertion: Inner bicipital ridge of humerus. Action: draws humerus downward and backward, and is internal rotator. Nerve supply: Subscapular nerve. 262 MEDICAL RECORD. Gracilis. Origin: Symphysis pubis. Insertion: Upper part of inner surface of shaft of tibia. Action: Flexes leg, rotates it inward, and adducts thigh. Nerve supply: Obturator nerve. PHYSIOLOGY. i. (a) Human physiology is that branch of science which treats of the functions of the organs and tissues of the human body in a state of health. (b) Physiological leucocytosis is an increase in the num- ber of the white blood corpuscles occurring under normal or physiological conditions, such as : Digestion, exercise, after a cold bath, or during pregnancy. (c) The normal blood pressure in the brachial artery is between no and 130 millimeters of mercury. 2. Normal urine is a yellowish fluid secreted by the kid- neys to the amount of about 1200-1500 c.c. daily; specific gravity, about 1015 to 1025; acid reaction (due to acid sodium phosphate) ; it has a characteristic odor and a salty taste. Its normal constituents are : Water, urea, uric acid, urates, hippuric acid, kreatin, kreatinin, xanthin, hypoxanthin; sulphates, chlorides, and phosphates of so- dium and potassium; phosphates of magnesium and cal- cium; nitrogen, and carbon dioxide. The most frequent abnormal constituents are: Albumin, casts, sugar, blood, pus, excess of indican, bacteria, bile. 4. Absorption is the process by which the products of digestion are conveyed to the circulation. Nutrition is the sum of the processes by which the body digests, ab- sorbs, and assimilates suitable materials brought into con- tact with it. 5. Pepsin is found in the gastric juice; it changes pro- teids into proteoses and peptones in an acid medium. Trypsin is found in the pancreatic juice; it changes pro- teids into proteoses and peptones in an alkaline medium, and afterwards decomposes them into leucin and tyrosin. Glycogen is found in the liver (also in placenta, white blood corpuscles, muscle tissue, etc.) ; it is a source of sugar and of energy. Ptyalin is found in the saliva; it changes starches into dextrin and sugar. Synovia is found in the joints and bursae; it acts as a lubricant. 6. There are two normal heart sounds which follow in quick succession, and are succeeded by a pause. The first, or systolic, sound is dull and somewhat prolonged; the second, or diastolic, sound is sharper and shorter. The sounds may be expressed by the syllables lubb — dup. The first sound is heard best at the apex beat in the fifth left intercostal space; the second sound is heard best over the second right costal cartilage. The causes producing the first sound of the heart are not definitely ascertained; the following are supposed to be causatory factors: (1) The 263 MEDICAL RECORD. vibration and closure of the auriculoventricular valves, (2) the muscular sound produced by the contraction of the ventricles, and (3) the cardiac impulse against the chest wall. The second sound is caused by the vibration due to the closure of the semilunar valves. 7. Function of Pneumo gastric Nerve: It supplies (1) motor influence to the pharynx and esophagus, stomach, and intestines, to the larynx, trachea, bronchi, and lungs ; (2) sensory and, in part, (3) vasomotor influence, to the same regions; (4) inhibitory influence to the heart; (5) inhibitory afferent impulses to the vasomotor center; (6) excito-secretory to the salivary glands; (7) excito-motor in coughing, vomiting, etc. 8. The functions of the skin are: (1) Protection, (2) excretion, (3) secretion, (4) heat regulation, (5) absorp- tion, (6) general sensation, (7) special sense of touch, and (8) respiration. (1) By its mechanical covering, and also by its being an organ of sensation. (2) Very slight; and see (3). (3) It secretes sebum to lubricate the hairs, and sweat (which has several functions : excretion of water, carbon dioxide, and urea; cooling of surface of body; and regu- lator of body heat). (4) By radiation, and see 3. (5) Very slight, chiefly of oily substances. (6) and (7) By end organs. (8) A slight amount of carbon dioxide is exhaled. 9. Lymph. Origin: There are two theories as to the formation of lymph: (1) That it is formed from the blood plasma by the processes of filtration, diffusion, and osmosis. (2) That in addition to these, the endothelial cells of the capillaries exercise some influence. Descrip- tion: Lymph is a colorless, albuminous fluid, alkaline in reaction, with specific gravity of about 1015, containing lymph corpuscles, and coagulating when drawn from its vessels. Composition: Proteins (serum albumin, fibrino- gen), sugar, sodium chloride and carbonate, water, urea, fat. Function: To provide cells and tissues with materials necessary for their growth, repair, and functional activi- ties ; and to receive and carry away their waste product's. 10. The pulse is a wave of expansion which travels along the arteries, and is due to the discharge from the left ventricle of a volume of blood, during systole, into the already full arterial system. The points to be observed are: (1) Its frequency; this gives the rate of the heart beats. (2) Its compressibility ; this denotes the force with which the heart is beating. (3) Its tension; this denotes the peripheral resistance, and also the state of the arterial walls. (4) Its regularity or rhythm; this denotes the regularity (or otherwise) of the heart's action in force or rhythm. The average rate during infancy is about 120 264 MEDICAL RECORD per minute ; during youth, about 80 ; and during old age, about 60. The normal ratio of pulse to respiration is about 4:1. CHEMISTRY. 1. Diffusion is the thorough mixing of liquids or gases which occurs when they are brought together. Thus, two liquids of different densities, even when at perfect rest, will soon have diffused into each other to form a single liquid whose density and composition are the same throughout. Dialysis is the process of separating sub- stances from each other by placing the mixture contain- ing them in a vessel w T ith porous walls and immersing it in water, when the more diffusible substance will pass through. Reagents are substances used to produce chem- ical reactions ; for example, see Question 6 below : By oxidation we mean the act of union of oxygen with another element or compound. This process is attended by the liberation of heat, and, when it takes place rap- idly, of light. The rusting of a given weight of iron is a slow oxidation, while the burning of the same in oxygen is a rapid oxidation. Only the latter produces light, while in both cases the same amount of heat is liberated. By combustion, in a general sense, is meant the rapid union of the oxygen of the air with some other substance, as coal or phosphorus. In a wider sense, however, com- bustion may be defined as any chemical union of two sub- stances attended by liberation of heat and light. 2. (a) Acid, (b) To hydrochloric acid. 3. Potassium Permanganate is a dark crystalline sub- stance, yielding a red powder when broken. It is soluble in water, and gives it a red color even in very dilute solu- tions. It is an oxidizing agent, and disinfectant. Its formula is K 2 Mn 2 O s . 4. One chemical antidote for phenol, sodium sulphate ; for arsenious oxide, freshly prepared solution of ferric hydroxide ; for sulphuric acid, magnesia ; for mercuric chloride, white of egg: for oxalic acid, magnesia. 5. (a) Ba0 2 +H 2 S0 4 = BaS04 + H 2 2 (b) 2KI -f- HgCl, = 2KCI + Hgl 2 (c) Na.,C0 3 + CaCl 2 = 2NaCl + CaCOs (d) Pb(X0 3 ) 2 4- Na 2 S0 4 = PbSO* + 2NaN0a (e) 2KOH + H 2 S0 4 = K 2 S0 4 + 2H 2 6. Test for albumin: "The urine must be perfectly clear. If not so, it is to be filtered, and if this does not render it transparent it is to be treated with a few 7 drops of mag- nesia mixture and again filtered. The reaction is first ob- served. If it be acid, the urine is simply heated to near the boiling point. If the urine be neutral or alkaline, it is rendered faintly acid by the addition of dilute acetic 265 MEDICAL RECORD. acid and heated. If albumin be present, a coagulum is formed, varying in quantity from a faint cloudiness to en- tire solidification, according to the quantity of albumin present. The coagulum is not redissolved upon the addi- tion of HN0 3 ." Test for sugar: Render the urine strongly alkaline by addition of Na 2 C0 3 . Divide about 6 c.c. of the alkaline liquid in two test-tubes. To one test-tube add a very min- ute quantity of powdered subnitrate of bismuth, to the other as much powdered litharge. Boil the contents of both tubes. The presence of glucose is indicated by a dark or black color of the bismuth powder, the litharge retaining its natural color. Test for bile pigment in the urine: Put 3 c.c. HNO3 in a test-tube; add a piece of wood, and heat until the acid is yellow; cool. When cold, float some of the urine to be tested upon the surface of the acid. A green band is formed at the junction of the liquid, which gradually rises, and is succeeded from below by blue, reddish-violet, and yellow. 7. Iodoform has formula CH1 3 . It is a solid, yellow, crystalline substance, insoluble in water, soluble in al- cohol and in ether, with a sweet taste and a peculiar pene- trating odor. It is used as a dressing for wounds, sores and ulcers (particularly tubercular and syphilitic ulcers). 8. Foods are classified as follows : _ T . (Water. I. Inorganic. J Salts (Sodium Chloride.) r Non-nitrogenous [Carbohydrates (Sugar). II. Organic < (Fats (Fat). (_ Nitrogenous — Proteids (Meat). 9. Mono denotes one; thus, CO carbon monoxide. Di means two ; thus, H2O2 hydrogen dioxide. Tri means three; thus C 3 H 5 (OH) 3 glycerol is a triatomic alcohol. Tetra means four; thus, carbon is tetravalent. Penta means five; thus PCI5 phosphorus pentachloride. 10. Marsh's test for arsenic: This test depends on the fact that arsenic hydride is formed when nascent hydro- gen acts on a compound of arsenic: H 3 As03+3H 2 =AsH3+3H 2 0. A small flask fitted with thistle funnel and a delivery tube, as for the production of hydrogen, is used; pure zinc and hydrochloric acid are introduced, and after a short time the hydrogen is ignited. It is advisable to. cover the flask with a cloth before igniting the gas, as an explo- sion may happen unless the air has all been driven out. If the materials are pure the hydrogen flame gives no deposit upon a piece of cold porcelain brought into it, but commercial zinc usually contains arsenic. When the purity of the gas is proved, a little solution of arsenite may be 266 MEDICAL RECORD. poured down the thistle funnel, which will produce a more rapid evolution of gas, and the flame will become larger and perceptibly colored. A piece of cold porcelain de- pressed upon the flame will be covered with a deposit of metallic arsenic. The films of arsenic are metallic looking in the thicker places, brownish near the edges; they are easily volatized by heat, and dissolve in solution of bleach- ing powder. A portion of the glass tube from which the gas is burned should be heated to redness ; the gas decom- poses and a deposit of arsenic appears on the tube, which may be identified in a similar way, or may be converted into crystals of oxide by cautious sublimation in an open tube. — (Fisher's Elementary Chemistry.) MATERIA MEDICA. i. Opium is obtained by incising the unripe capsules of Papaver somniferum. It should yield not less than nine per cent, of morphine. Two alkaloids: Morphine, dose gr. 1/5; Codeine, dose gr. ^2. 2. (a) Fowler's Solution is liquor potasii arsenitis. Its composition is : Arsenic trioxide, potassium bicarbonate, compound tincture of lavender, and water. (b) Donovan's Solution is liquor arseni et hydrargyri iodidi. Its composition is : arsenous iodide, red mercuric iodide, and water. 3. (1) Hydrargyri chloridum corrosivum; (2) Hydrar- gyri chloridum mite; (3) Hydrargyri iodidum flavum; (4) Hydrargyri iodidum rubrum; (5) Hydrargyrum cum creta. 4. Infusion of digitalis, dose 3ij ; Fluidextract of ergot, dose H£xxx; Oleum terebinthinse, no dose; Sodium salicy- late, dose gr. xv; Tinctura opii deodorati, dose Tl£viij. 5. Epsom salt.. Rochelle salt. Glauber's salt OFFICIAL NAME. Magnesii sulphas Potassii et sodii tartras Sodii sulphas DOSE. ~3i7 3ij 3iv 6. By incompatibility is understood the simultaneous ad- ministration or combination of substances not suitable for such combination. Varieties: Chemical, pharmaceutical, and therapeutical. 7. I would not write potassium chlorate and tannin in the same prescription ; because the combination is explosive. 8. Narcotics are agents which produce deep sleep; as opium. Anesthetics are agents which destroy sensation; as ether. Sedatives are agents which reduce functional activity and diminish pain ; as aconite. 9. Quinine, quinidine, cinchonine, cinchonidine. 267 MEDICAL RECORD io. Potassium iodide, dose gr. vijss; potassium chlorate, dose gr. iv; potassium bitartrate, dose gr. xxx. THERAPEUTICS. 1. Two respiratory stimulants: Strychnine, dose of sul- plate, gr. 1/64; and citrated caffeine, dose gr. ij. Two vasomotor depressants: Amyl nitrite, dose T^iij ; and aco- nite, dose of tincture, TT#x. 2. Cardiac sedatives lessen the force and frequency of the heart's action. They are used to control palpitation and overaction of that organ, also to slow the pulse in febrile conditions in sthenic subjects, especially when local inflammation is the exciting cause thereof. Most of them are direct cardiac poisons, depressing both the heart muscle and the motor ganglia. The list includes Aconite and Veratrum, also Muscarine, Pilocarpine, Saponin, Hydro- cyanic Acid, Antimony, Potassium salts, and Digitalis, the last-named acting as a sedative by stimulation of the vagus center and the cardiac muscle, slowing the rate and giving regular rhythm to the action of the heart. — (From Potter's Materia Medica.) 3. Diaphoresis is produced: (1) To remove fluid from the body. (2) To remove poisons from the body. (3) To reestablish disturbed cutaneous circulation, and so to relieve congestion of internal organs. (4) To relieve the kidneys, (5) To increase the alkalinity of the tissues. Three diaphoretics: Alcohol, aconite, and pilocarpus. 4. The following table (from Potter's Materia Medica) gives the chief antipyretics, with their manner of action: Temperature depression may be done by five different actions working upon two principal lines, viz., by: ' ( 1 ) diminishing tissue change. (2) reducing the cir- culation. (3) dilating cutaneous ves- sels, thus increasing heat radiation. (4) promoting perspiration, its evaporation lower- ing the temperature. (5) abstracting heat from the body. The following list of antipyretics includes a few for each of the above-named actions, to which the numbers refer in each case, viz. : Quinine, 1. Aconite, 2. Antipyrin, 1, 4. Phenol, 1. Alcohol, 1, 3. Antimony, 2, 4. Salicin, 1. Nitrous ether, 3, 4. Cold bath, 5. Digitalis, 2. Acetanilid, 1, 4. Cold drinks, 5. Phenacetin, 1, 4 Wet-pack, 5. 268 (a) Lessening heat production by (b) Promoting heat loss by MEDICAL RECORD. 5. Anthelmintics are agents which kill or expel worms inhabiting the intestinal tract. Examples: Oleoresina aspidii, gr. xxx ; Pelletierine tannate, gr. x ; santonin, gr. j ; pumpkin (pepo) seeds, 3J. 6. How antitoxin produces immunity and affects cure is not known, but theories deduced from observed facts are as follows : "As the various pathogenic bacteria produce the causative toxins of their respective diseases, so the organic cells of the body, reacting under the stimulus of the poisons thus introduced, immediately proceed to elab- orate defensive bodies, which if produced in sufficient quantity will neutralize the effects of the toxins. Residual antibodies remaining in the blood after recovery render the animal immune for a time against the disease. The immunizing and curative effects obtained by the injection of the blood serum of an immunized animal into the circulation of another animal are due either to direct chem- ical neutralization of the toxins themselves by the anti- bodies so introduced (Behring, Kitasato), or to a par- ticular influence exerted by the antibodies upon the living cells of the organism which, being affected in two opposite directions, remain neutral to the disease (Buchner). Some authorities hold that these results are due to the conjoint action of leucytic and chemical forces. Ehrlich , s side- chain theory assumes that every toxin contains toxophore molecules having direct toxic action, and haptophore mole- cules which combine the toxophores with a similar com- bining group of molecules in the tissue cell of the attacked organism. The tissue cell molecules being destroyed by the toxophores, a rapid and profuse regeneration of similar molecules occurs in side chains, and these molecules over- growing are carried into the circulation, becoming the antitoxin, which acts by combining with the haptophores of newly arrived toxin, using up their combining power before they can reach the tissue cells." — (Potter's Materia Medica, etc.) 7. Besides being an anesthetic, chloroform is a rubefa- cient, an anodyne, an antipruritic^ it is administered inter- nally as a stomachic, in dyspepsia, to disguise nauseous drugs, in diarrhea, in irritating coughs and bronchitis. 8. Cumulative action is the property which some drugs have of producing more or less sudden and violent action, after single and successive doses have been taken with no untoward effect. Example: Digitalis; this produces fast and irregular pulse, gastroenteritis, small pulse, low blood pressure. 9. The important alkaloid of erythroxylon is cocaine; its principal therapeutic use is as a local anesthetic. 10. Preparations of bismuth are used: (1) Externally, as dusting powders for wounds, sores, some skin diseases; 269 MEDICAL RECORD. (2) internally, in vomiting, diarrhea, gastritis, gastralgia, and as an intestinal antiseptic; (3) also in sore mouth, conjunctivitis, granular lids, coryza, mercurial ptyalism. PATHOLOGY. 1. (a) Calcification is a pathological process in which certain tissues are infiltrated with calcareous particles (salts of calcium and magnesium), (b) Neuroma is a tumor consisting almost entirely of nerve tissue. Angioma is a tumor consisting of blood-vessels bound together by a small amount of connective tissue, (c) A retention cyst is a cyst which results from the retention of a normal secretion (as a sebaceous cyst) ; (d) Fatty, calcareous, hyaline, and amyloid degenerations, (e) Osteomalacia is a disease characterized by progressive softening of the bones. 2. Carcinoma is derived from the epiblast or the hypo- blast; possesses a stroma, in which are both blood-vessels and lymphatics; metastasis occurs by the lymphatics. Sarcoma is derived from the mesoblast; it has no stroma and no lymphatics; metastasis occurs by the blood-vessels which are in contact with the cells. 3. See French's "Practice of Medicine" (1907), page 539; or Osier's "Practice of Medicine" (1909), page 756. 4. In tabes dorsalis the posterior columns of the spinal cord and the posterior nerve roots are involved. The posterior columns of the spinal cord are gray and shrunken, and show considerable overgrowth of connective tissue in the columns of Goll, Burdach, and Lissauer; this process extends upward from the lumbosacral region ; the posterior nerve roots degenerate and become atrophic. The menin- ges over the affected parts become opaque and adherent. Some of the cranial nerves may also atrophy, notably the optic, but also the motor oculi and vagus. The process is destructive and progressive; it is not a simple wasting, although the nerve fibers are atrophied,^ but it is charac- terized by irritation, changes in the axis cylinders, over- growth of the connective tissue, and sometimes congestion ; the spinal ganglia may be affected. 5. In atrophic cirrhosis: The liver is shrunken and in- durated, rough, and of a pale or yellow color; a growth of new connective tissue is disposed in broad bands which run in various directions, and by their contraction divide the liver into numerous irregular lobes. Many acini may be affected at one time. The capsule may be thickened, or adherent to the diaphragm. Jaundice is slight, and comes on late; ascites is pronounced and may occur early. 6. See French's "Practice of Medicine" (1907), page 154; or Osier's "Practice of Medicine" (1909), page 170. 7. A diplo coccus is a form of bacteria made up of two 270 MEDICAL RECORD. cocci attached to each other (in pairs). Two pathogenic diplococci : Diplococcus pneumonia: and Diplococcus intra- cellulars meningitidis. 8. (a) Germicide as an agent capable of destroying bac- teria, (b) Antiseptic is an agent capable of preventing or restraining putrefaction, (c) Asepsis means freedom from pathogenic germs, (d) Sterile means containing neither microorganisms nor spores capable of development, (e) Disinfectant is an agent which restrains infectious diseases by destroying or removing their specific poisons. 9. Most bacteria require proper temperature, generally at or near that of the body; oxygen is generally needed, those that cannot live without it being called aerobic, and those that can grow without it, anaerobic; nutriment of a proper kind, containing both organic and inorganic ma- terial; a slight degree of moisture; a medium of slightly alkaline reaction; and rest. Individual bacteria may re- quire modifications of the above essentials. 10. Human blood serum. PRACTICE. 1. (a) Epidemic parotitis is inflammation of the parotid gland (or mumps), occurring in a large number of people at the same time, (b) An endemic disease is one which is more prevalent in certain localities than elsewhere; an epidemic disease is one which attacks a large number of persons in the same locality in rapid succession. (c) Dysphagia means painful or difficult swallowing; it occurs in peritonsillar abscess, tonsillitis, cancer of tongue, pharyn- gitis, etc. (d) Koplik's sign is the presence of small red spots with a bluish-white center on the inner surface of the cheeks, found in measles prior to the development of the eruption on the skin. Kernig's sign is inability to fully straighten the leg after both thigh and leg have been flexed ; it is found in cerebrospinal meningitis. 2. (a) Percussion is a method of diagnosis, and consists in striking a part with a view to determining the condition of the underlying organs by the sound elicited, (b) In- spiration is the act of breathing in. (c) Mensuration means measuring, (d) Palpation is a method of diagnosis, and consists in feeling or pressing over an organ with fingers or hands, (e) Auscultation is a method of diagno- sis, and consists in listening to the sounds of the heart, blood-vessels, or respiratory apparatus. (/) Succussion is a method of diagnosis, and consists in snaking (slightly) the patient or some viscus. (g) Egophony is a form of vocal resonance in which the voice sounds tremulous and bleating. 3. Spasmodic croup generally comes on suddenly, at night. There is no appreciable fever, no previous malaise 271 MEDICAL RECORD or sickness, and often the patient is asleep again by the time the physician arrives. There is frequently a thick, tenacious mucus, but neither Klebs-Loeffler bacilli nor streptococci are present. It is entirely a local disturbance. Membranous croup is either laryngeal diphtheria or a streptococcus infection. In either case there is a prior stage of malaise, accompanied by chills, fever, and sore throat. The fever may become very high. A membrane forms, in which are found the Klebs-Loeffler bacilli or streptococci. For treatment, see French's "Practice of Medicine" (1907), pages 647 and 195; or Osier's "Practice of Medi- cine" (1909), pages 599 and 207. 4. In varicella the symptoms come on gradually; there i-s no prodromal fever; no pain in the back; the eruption appears on the first day, comes in crops, disappears on stretching the skin, and is not shotty. In varioloid the symptoms come on very suddenly; there is fever; severe pain in the back, and headache; the erup- tion appears on the third or fourth day, as papules, be- coming in turn vesicles and pustules. 5. EPILEPSY. HYSTERIA. I. No apparent cause. I. Cause, emotional. 2. Sudden and rapid onset. 2. Onset gradual, usually after some mental ex- citement. 3- Aura generally present. 3. Globus hystericus or pal- pitation. 4- Consciousness lost. 4. Consciousness generally preserved. 5- Pupils generally dilated. 5. Pupils normal. 6. Tongue often bitten. 6. Tongue never bitten. 7- Patient very liable to 7. Patient not liable to hurt hurt himself. himself; may injure others. 8. May be involuntary blad- der and bowel dis- charges. 8. Never. 9- Of short duration. 9- Duration longer. 6. See French's "Practice of Medicine" (1907), page 548; or Osier's "Practice of Medicine" (1909), page 766. 7. See French's "Practice of Medicine" (1907), page 871; or Osier's "Practice of Medicine" (1909), page 589. 8. See French's "Practice of Medicine" (1907), page 221; or Osier's "Practice of Medicine" (1909), page 213. 9. See French's "Practice of Medicine" (1907), page 944; or Osier's "Practice of Medicine" (1909), page 420. 272 MEDICAL RECORD. io. See French's "Practice of Medicine" (1907), page 995. SURGERY. 1. An abscess is a circumscribed collection of pus in a cavity of new formation. An aneurysm is a pulsating sac containing blood com- municating with the lumen of an artery; it may be con- founded with abscess, cyst, soft tumor. 2. Peritonitis is inflammation of the peritoneum. 3. See Rose and Carless' "Surgery" (1908), page 333; or Da Costa's "Surgery" (1908), page 410. 4. See Rose and Carless' "Surgery" (1908), page 868. 5. The more common errors of refraction are : Myopia, hypermetropia, and astigmatism. Myopia is a condition in which the anteroposterior axis of the eye is abnormally long, and parallel rays are focused in front of the retina. Hypermetropia is a condition in which the anteroposterior axis of the eye is abnormally short, and parallel rays are focused behind the retina. Astigmatism is a condition in which, owing to a greater curvature of the eye in one meridian than in others, the refractive power of the eye varies. 6. Glaucoma is a diseased condition of the eye especially characterized by increased intraocular tension. Surgical treatment is iridectomy: "Having first secured a lid specu- lum in position, a fold of conjunctiva, near the cornea and opposite the place where the incision is to be made, is seized by fixation forceps. A keratome is entered through the cornea at the scleral border, the point being kept nearly perpendicular to the sclera until it has reached the anterior chamber, when the handle is depressed so as to bring the blade parallel to the iris. The blade is then pushed forward until it has made a wound sufficiently large for the purpose of the operation ; still depressing the handle, the blade is withdrawn slowly, and iris for- ceps are thrust through the wound closed, and opened in the anterior chamber to seize the iris. The iris is then drawn out of the wound, and as much of it as desired is excised by fine iridectomy scissors held firmly against the eyeball and parallel to the wound. The stump of the iris is then carefully returned to the anterior chamber, no portion of it being allowed to become incarcerated in the corneal incision. The delicate McClure iris scissors are the best for cutting the iris, but they are rather expensive, and not always obtainable. The eye should be thoroughly cocainized, and the opera- tion should be done under antiseptic precautions ; after the operation the eye should be thoroughly irrigated, a light bandage applied, and the eye kept closed until the corneal 273 MEDICAL RECORD. incision has become united. The incision may be made with the Graefe knife instead of the lance-shaped kerat- oma" — (Gould and Pyle's Compend.) 7. See Rose and Carless' "Surgery" (1908), page 232. 8. See Rose and Carless' "Surgery" (1908), page 679; or Da Costa's "Surgery" (1908), page 552. 9. See Rose and Carless' "Surgery" (1908), page 1318; or Da Costa's Surgery (1908), page 1046. 10. See Rose and Carless' "Surgery" (1908), page 1061 ; or Da Costa's "Surgery" (1908), page 965. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), page 81; or Hirst's "Obstetrics" (1909), page 57. Menstruation may be absent, owing to absence or im- perfect development of the generative organs; also to stenosis, obstructions, or atresia of the genital tract; also to operative removal of the uterus or its appendages. Other causative factors are : Acute infectious diseases, anemia, chlorosis, obesity, drug habits, alcoholism, over- study, lack of exercise, exposure to cold, and various emo- tional causes. 2. See Williams' "Obstetrics" (1909), page 211; or Hirst's "Obstetrics" (1909), page 389. 3. Puerperal eclampsia is an acute morbid condition, oc- curring during pregnancy, labor, or the puerperal state, and is characterized by tonic and clonic convulsions, which af- fect first the voluntary and then the involuntary muscles; there is total loss of consciousness, which tends either to coma or to sleep, and the condition may terminate in re- covery or death. Preventive treatment: (1) The amount of nitrogenous food should be diminished to a minimum; (2) the production and absorption of poisonous materials in the intestines and body tissues should be limited and their elimination should be aided by improving the action of the bowels, the kidneys, the liver, the skin, and the lungs; (3) the source of the fetal metabolic products and the peripheral irritation in the uterus should, if necessary, be removed by evacuating that organ. Curative treatment: (1) Controlling the convulsions (by chloroform, veratrum, or chloral) ; (2) elimination of the poison or poisons which are presumed to cause the convulsions; (3) empty- ing the uterus under deep anesthesia, by some method that is rapid and that will cause as little injury to the woman as possible. 4. See Williams' "Obstetrics" (1909), page 842; or Hirst's "Obstetrics" (1909), page 625. 5. See Williams' "Obstetrics" (1909), page 274; or Hirst's "Obstetrics" (1909), page 409. 6. In incomplete laceration of the perineum any of the 274 MEDICAL RECORD. following tissues may be lacerated : Skin, mucous mem- brane of fourchette, constrictor vaginae, transversus peri- nei, and lavator ani. In complete laceration the sphincter ani and the anterior surface of the rectum are involved, in addition to the structures named above. For repair, see Williams' "Obstetrics" (1909), page 325; or Hirst's "Obstetrics" (1909), page 868. 7. Membranous Dysmenorrhea. "Pathological anat- omy: When complete the membrane is a hollow cast of the interior of the uterus ; it is the shape of an isosceles triangle, the base of which corresponds to the fundus of the uterus. At each of the truncated angles there is an opening, the small ones at the base indicating the position of the uterine ostia of the Fallopian tubes, and the larger apical opening marking the site of the os internum. A menstrual decidua is usually 2.3 centimeters in length and 2 millimeters in thickness. The inner surface is shaggy, as is best seen when the membrane is floated out in water. Histologically, the membrane consists of recent blood-clot, characterized by the presence of a large excess of leuco- cytes ; fragments of organized tissue are found, consisting of small round cells with a small amount of delicate fibrous stroma, and sometimes portions of shed and par- tially disintegrated epithelium. No glands are found, nor are the large decidual cells characteristic of the decidua of pregnancy present. The condition is best described as one of exfoliative menstrual endometritis. Symptoms: The patient complains of severe intermittent pain, begin- ning with the onset of the menstrual period and reaching a maximum just before the expulsion of the membrane, after which the pain usually ceases. The membrane may come away whole, in several pieces, or in numerous shreds, and is usually discharged within forty-eight hours of the commencement of the menstrual flow. Diagnosis: The membranous cast must be distinguished from the decidua that comes away in cases of tubal pregnancy, or from the unimpregnated horn of a gravid uterus, and from the products of early abortion. The histological appearances will usually be decisive ; in addition to which the history will generally serve for a diagnosis. In cases of deciduse associated with pregnancy within or without the uterus there is always a history of one or more missed periods, except in some few cases of tubal gestation. The hemor- rhage in cases of membranous dysmenorrhea is limited to the usual few days, while in cases where the member is de- cidual it may go on for one or several weeks. When the case has been under observation some time the regular painful discharge of membranes at monthly intervals is ab- solutely characteristic. Treatment: No drugs affect the for- mation of the membrane, although pain may be relieved by -75 MEDICAL RECORD. this means. The incidence of pregnancy sometimes effectu- ally arrests the membranous formation, but not always. The best results are obtained from curetting, which affords at least a temporary relief; but it may require to be re- peated." — (Sutton and Giles' Diseases of Women.) 8. The round ligaments are shortened when the uterus is retroverted, or retroflexed, and there are no complica- tions. See Hirst's "Obstetrics" (1909), page 914; or Rose and Carless' "Surgery" (1908), page 1278. 9. Ovarian dermoids: Dermoids are "tumors furnished with skin or mucous membrane occurring in situations where these structures are not found under normal condi- tions." Ovarian dermoids may be lined with skin through- out, or only over a very bmall area. The Sidn may have hair, sebaceous glands, sweat glands, mammae. There may be teeth, muscle, bone, horn, nails; very rarely brain-like tissue. The cavity of a dermoid cyst is generally filled with fluid fat. 10. The cause of icterus of the new-born is not known. It is found most often in premature and weakly infants, and in those born in maternity hospitals. The following theories have been held as to its etiology: "(1) Obstruction to the outflow of bile by (a) plugs of mucus in the com- mon bile duct; (b) partial blocking of the bile ducts by desquamated epithelium, the result of hyperemia and ca- tarrh of the ducts following on the changes in the circula- tion which take place at birth; (c) congenital narrowing of the bile ducts; (d) inability of the ducts to carry off the secretion of bile, which is considerable at first; and O) delayed ligature of the cord. (2) Pressure on the ducts from without by (a) the portal and hepatic veins becoming distended in consequence of the changes in the circulation following birth; (b) swelling and edema of Glisson's capsule, the result of engorgement of the umbili- cal and portal veins — hence the jaundice is hepatogenous. (3) Closure of the umbilical vein, which leads to such a lowering of blood pressure in the capillaries of the liver that reabsorption of bile takes place. (4) The ductus venosus remains open and thereby allows some portal blood, which contains bile, to pass through it and enter the inferior vena cava." — (From Aids to Diseases of Children. ) STATE BOARD EXAMINATION QUESTIONS. Massachusetts Board of Registration in Medicine. anatomy and histology. I. Describe the arrangement of the dura mater and state functions 276 MEDICAL RECORD. 2. Make a diagram of the stomach, moderately distended, and state its anatomical relations. 3. Describe the portal circulation and state how it is con- nected with the systemic. 4. What is Poupart's ligament? State origin and inser- tion, and the structures which pass under it. 5. Describe a muscle fiber. Name three parts of the body in which unstriped muscle is found. 6. State origins of vertebral, internal mammary, and basilar arteries. 7. Name the largest cranial nerve. How many roots has it, and what is its superficial origin? Why is it called a compound nerve? 8. Make a diagram of the second nerve. What is its ex- clusive distribution? 9. Locate and give the gross anatomy of the medulla oblongata. 10. Oral examination. PHYSIOLOGY AND HYGIENE. i. State the functions of the fifth nerve. 2. Trace the nervous path in case of reflex action. Is walking a reflex? 3. What is the purpose of the Haversian canals? What is the function of the marrow and the periosteum? 4. Name and locate the valves of the heart and state their functions. What is the velocity of the blood current? 5. When food of various types is digested, where and in what way does it enter the blood stream ? 6. Describe the phenomena which occur when muscle is in a state of activity. 7. What objections may be given to heating dwelling rooms by direct radiation from stoves and from steam or hot water pipes? What would you recommend as a substitute? 8. What conditions tend to prolong the life of a bacillus outside of the body? 9. Mention diseases where germs are carried by water; also by air. 10. Oral examination. PATHOLOGY AND BACTERIOLOGY. 1. Differentiate death by drowning and death by strangu- lation. 2. Name and describe five abnormal constituents of urine which signify disease. How are they determined? 3. State pathological conditions for relief of which diu- retics are generally administered. 4. Describe a tubercle. What is its origin and what tis- sues are most frequently invaded by it? 277 MEDICAL RECORD. 5. Give the pathology of the initial, the secondary, and the tertiary stages of syphilis. 6. Why does metastasis in carcinoma occur through the lymphatic system and sarcoma through the venous system? 7. What classification is made of bacteria based on the shape of the individuals? 8. What classification of the cocci, based on the arrange- ment of the individuals composing the groups, can you mention ? 9. What bacterium is associated generally with specific urethritis? How may it be determined? 10. State the pathology of hydrocele. DIAGNOSIS AND THERAPEUTICS. i. What is glaucoma? Discuss symptoms and treatment. 2. Define and differentiate hallucinations, delusions, and illusions. 3. Describe paralysis agitans. Give etiology and prog- nosis. 4. Describe characteristic findings in the urine in a case of acute nephritis. 5. Give the symptoms indicating intestinal perforation in typhoid fever. What treatment may avail? 6. Outline the treatment of a case of diphtheria by the use of antitoxin. What is the principle upon which the antitoxin treatment is based? 7. How should an abscess of the middle ear be treated? What serious complications may arise from such an ab- scess? 8. What are the indications and contraindications as to the use of digitalis as a cardiac stimulant? 9. Differentiate diabetes mellitus and diabetes insipidus. What treatment does the latter demand? 10. What is the significance of the patellar reflex as in- dicative of disease? PEDIATRICS AND TOXICOLOGY. i. Symptoms and treatment of tuberculosis of the nose; also of the eye and of the ear. 2. Describe tuberculosis of the lymphatic glands and out- line treatment. 3. State the nature, symptoms, course, and treatment of Pott's disease. 4. Describe scabies. How would you treat a well de- veloped case? I 5. Describe and differentiate pemphigus and varicella. 6. Describe catarrh of the middle ear; etiology, symp- toms, course, and treatment. 7. Arriving within five minutes after your patient has swallowed a 2-ounce solution containing 5 to 8 grains of 278 MEDICAL RECORD. cocaine hydrochlorate, in what condition would you expect to find him, and what would you do for him? 8. Arriving an hour after your patient had taken cocaine as mentioned in question 7, in what condition would you expect to find him, and what would you do for him? 9. State in detail what you would consider the most effi- cient treatment, when promptly administered, for a patient who has swallowed a dangerous dose of carbolic acid? Should the treatment be delayed for half an hour to an hour after ingestion of the dose, what would be your treatment ? 10. In what manner does death ensue in poisoning by hydrocyanic acid, by aconite, by morphine, by atropine, by strychnine ? SURGERY. 1. Give etiology, symptoms, and treatment of empyema. State usual results when not treated. 2. Differentiate chancre and chancroid, and state treat- ment for each. 3. State the symptoms of fracture of both bones of the forearm in their middle third. How would you treat a case? 4. State the causes of nonunion in bone fractures. What should be the treatment in such cases? 5. Differentiate piles, fistula, and fissure. Treat the last. 6. Discuss ascites — causes, differential diagnosis, and treatment. 7. Give the symptoms of renal calculus. State cause and treatment during an attack, and also treatment in the interval between attacks. 8. State the diagnostic points in prostatic hypertrophy. Give palliative treatment. 9. Define psoas abscess. What is the nature of its fluid? What can you say as to its treatment? 10. Oral examination. OBSTETRICS AND GYNECOLOGY. 1. Discuss the conditions which may render anesthesia advisable during labor. What anesthetic would you use, and how would you' administer it? 2. Define second stage of labor and state the conditions which may cause delay of delivery in this stage, and how such conditions should be managed. 3. Describe toxemia as noted in pregnancy, and state measures of prevention and of alleviation. 4. Define endometritis and state cause, symptoms, and treatment. 5. Should the head of the child fail to enter the pelvic brim, how would you conduct your case of labor? 279 MEDICAL RECORD. 6. Mention not less than four conditions liable to cause prolapse of the cord, and outline the treatment for any one condition mentioned. 7. Differentiate the uterus of a virgin and that of a multipara, as observed in post-mortem examination. 8. Discuss possible injuries to the birth-canal incident to labor. How and when are they best discovered, and state how they should be treated. 9. How can you differentiate uterine and vaginal leucor- rhea? 10. Discuss gonorrhea in women — symptoms and far- reaching results. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Massachusetts Board of Registration in Medicine. anatomy and histology. i. For arrangement of dura, see Cunningham's "Anat- omy" (1909), page 597; or Gray's "Anatomy" (1908), page 972. The function of the dura is protection : It forms the internal periosteum of the skull, it forms three parti- tions for the support of the parts of the brain, it forms sinuses or venous channels for the return of the blood from the brain, and it forms sheaths for the nerves as they leave the skull. 2. See Cunningham's "Anatomy" (1909), page 1051 ; or Gray's "Anatomy" (1908), page 1277. 3. See Cunningham's "Anatomy" (1909), page 1120; or Gray's "Anatomy" (1908), page 768. 4. Poupart's ligament is formed by the lower border of the aponeurosis of the external oblique muscle; it extends from the anterior superior spine of the ilium to the spine of the pubes. The anatomical structures which lie beneath Poupart's ligament are (from without inward) : External cutaneous nerve, Iliacus, anterior crural nerve, Psoas, femoral artery, femoral vein, femoral ring. 5. See Gray's "Anatomy" (1908), page 364. Three places in which unstriped muscle is found : Arteries, stom- ach, intestines. 6. Vertebral artery is from subclavian artery ; internal mammary artery is from subclavian artery; basilar artery is from two vertebral arteries. 7. The largest cranial nerve is the fifth, or trigeminal. It has two roots. Its superficial origin is from the side of the pons Varolii, nearer to the upper than the lower border. It is called a compound nerve because it contains both motor and sensory fibers. 8. See Cunningham's "Anatomy" (1909), page 676; or 280 MEDICAL RECORD. Gray's "Anatomy" (1908), page 1038. It is distributed exclusively to the retina. 9. See Cunningham's "Anatomy" (1909), page 481; or Gray's "Anatomy" (1908), page 874. PHYSIOLOGY AND HYGIENE. i. The functions of the fifth cranial nerve. First ophthalmic branch supplies sensation to conjunctiva and skin of upper eyelid, cornea, skin of forehead and nose, lacrymal glands, mucous membrane of nose. Second, or superior maxillary branch, supplies sensation to skin and conjunctiva of lower lid, nose, cheek, upper lip, upper teeth and alveolar processes, and palate. Third, or inferior maxillary branch, supplies sensation to external auditory meatus, side of head, mucous membrane of mouth, an- terior two-thirds of tongue, lower teeth, lower lip, and skin of the lower part of the face. This branch, in addi- tion, supplies motion to the muscles of mastication (Mas- seter, Temporal, External, Pterygoid, Internal Pterygoid), also mylohyoid, and anterior belly of digastric. 2. Reflex actions are involuntary or unconscious move- ments, due to suitable stimuli. They depend upon the integrity of the reflex arc, which is a complex made up of: (1) A surface capable of receiving an impression; (2) an afferent nerve; (3) a nerve cell capable of receiving and also of sending out impulses; (4) an efferent nerve, and (5) a surface capable of responding in some way to the impulse conveyed by the efferent nerve. Reflexes are classified as: (1) Superficial, (2) deep, and (3) visceral. Example: The patellar reflex consists of a contraction of the extensor muscles of the leg and a movement of the foot forward when the ligamentum patellae is struck; the quadriceps extensor must first be slightly stretched by put- ting one knee over the other. Its integrity depends upon a healthy condition of the entire reflex arc, consisting of tendons, afferent or sensory nerve, pulsterior roots, and anterior horn of the spinal cord; the efferent or motor nerve, and the muscle itself. Strictly speaking, walking is primarily a voluntary act; but practically it may be con- sidered as a reflex. 3. The Haversian canals serve to conduct arteries, veins, lymphatics, and nerves to and from the bone substance. The marrow supports the blood-vessels, is concerned in the formation of bone, also nourishes spongy bone, and forms red blood corpuscles. The periosteum acts as a protection to the bone; also generates bone, aids in the repair of bone, and takes part in the nourishment of bone. 4. The valves of the heart are: In the right auricle, the Eustachian and coronary valves ; the former is situated between the anterior margin of the inferior vena cava 281 MEDICAL RECORD and the auriculoventricular orifice. In the fetus it directs the blood from the inferior vena cava through the fora- man ovale into the left auricle; the coronary valve pre- vents the regurgitation of the blood into the coronary sinus during the auricular contraction. In the right ven- tricle are the tricuspid and semi-lunar valves; the former prevents the blood in the right ventricle from flowing back into the right auricle during ventricular cystole; the latter guards the orifice of the pulmonary artery. In the left ventricle are the mitral and semi-lunar valves ; the former acts similarly to the tricuspid; the latter guards the orifice of the aorta. Aortic valves, behind the third intercostal space, close to the left side of the sternum. Pulmonary valves, in front of the aortic, behind the junc- tion of the third rib, on the left side, with the sternum. Tricuspid valves, behind the middle of the sternum, about the level of the fourth costal cartilage. Mitral valves, behind the third intercostal space, about one inch to the left of the sternum. The velocity of the blood current is about one foot per second in the arteries; about one inch per minute in the capillaries; and about eight inches a sec- ond in the veins. The complete circulation around the body is said to occupy a little less than half a minute. 5. The products of digestion find their way into the blood by two routes: (1) By the blood-vessels of the gastrointestinal tract, which unites to form the portal vein, and (2) by the lymph vessels of the small intestines, which converge to empty into the thoracic duct. The water, inorganic salts, proteids, and sugar go by way of the portal vein to the ascending vena cava; and the fats go by way of the thoracic duct to the junction of the left subclavian and internal jugular veins. 6. When a muscle is in a state of activity: (1) It be- comes shorter and thicker, but (2) there is no change in volume; (3) there is an increased consumption of oxygen; (4) more carbon dioxide is set free; (5) sarcolactic acid is produced; and hence (6) the muscle becomes acid in reaction; (7) it becomes more extensible, and (8) less elastic; (9) there is an increase in heat production and consequently a rise of temperature; (10) the electrical re- action becomes relatively negative; and (11) a sound is produced. 7. The objection to stoves is that the air gets dry and unpleasant, the air is thus often hotter than the walls and floor, and so chills are produced; the presence of carbon dioxide is often noted. Steam or hot-water pipes are about as good a method of heating a house as any known. 8. Conditions that tend to prolong the life of a bacillus outside of the body: Moisture, rest, moderate warmth, dim light, alkaline medium, and suitable nourishment. 282 MEDICAL RECORD. 9. Diseases whose germs are carried by water: Typhoid, cholera, dysentery, sometimes diphtheria; germs are car- ried by air: Tuberculosis, scarlet fever, measles, small- pox, pneumonia, influenza, diphtheria, and erysipelas. PATHOLOGY AND BACTERIOLOGY. i. In death by drowning: The surface is pallid, the face appears tranquil, the eyes and mouth being partly open. The skin often has the appearance known as goose- skin, and, if the body has lain upwards of twelve hours in the water, that of the hands and the feet is sodden by imbibition. The most important external sign is the pres- ence on the mouth and nostrils of a fine froth (possibly blood stained), composed of air, mucus, and the medium in which drowning took place; if the body remains three or four days in water, the froth disappears. Exceptionally, fragments of weeds or other small objects may be found tightly grasped in the hands. On opening the thorax the lungs, gray in color, with reddish staining, are seen to be very voluminous, a condition known as ballooning, partly due to infiltration of the lung tissue with some of the medium in which drowning took place, and partly to true edema. The lung substance is inelastic and pits on pres- sure. On section, fluid and froth resembling that found on the lips exude from the divided air passages. Minute subpleural hemorrhages are not infrequently present, and the pleural cavities may contain fluid. The stomach often contains water or other liquid which was involuntarily swallowed during attempts at respiration. Occasionally some of this fluid is forced by vital action into the in- testines. With one exception, the remaining appearances are those met with after death from asphyxia. The ex- ception is constituted by the blood, which is not only dark colored and fluid, as is usual after death from asphyxia, but is also diluted by the imbibition of water from the stomach and lungs. In death by strangulation: The blood is of a dark color, owing to complete reduction of the hemoglobin^ The proportion of carbonic acid is increased, and owing to its excess the blood coagulates slowly or imperfectly; hence it remains fluid or forms few and soft coagula. The large veins, the pulmonary artery, and the cavities of the right side of the heart may be distended with dark fluid blood, but this is by no means necessarily the case. The left side is usually empty or nearly so. The lungs may be congested, but are often pallid and anemic, though the dependent parts usually exhibit appearances of hypo- static engorgement. The abdominal viscera, especially the kidneys, are often congested. The appearance of the brain varies; it may be anemic or more or less congested. Spe- 283 MEDICAL RECORD cial signs characterize special modes of causation of as- phyxia. Very commonly punctate ecchymoses are visible on the conjunctiva, face, neck, and chest. They are consid- ered by Tardieu to be more frequent in strangulation than in asphyxia from other causes, or than in cases of over- straining, which likewise may lead to them. In the sub- cutaneous cellular tissue, and in the fascia of the muscles above and below the hyoid bone extravasations are fre- quently found, as well as on the external surface of the thyroid cartilage and trachea. The lungs vary as regards their vascularity; but on the surface it is common to find pseudomembranous patches, which are due to the rupture of some of the superficial air cells and collection of air bubbles under the pleura. In the substance of the lungs congested patches, or apoplectic extravasations, are often found, varying in size, but larger than those usually found in suffocation. — (From Quain's Dictionary of Medicine.) 2. Five abnormal constituents : Albumin, sugar, blood, bile pigment, and excess of indican. Test for albumin: The urine must be perfectly clear. If not so, it is to be filtered, and, if this does not render it transparent, it is to be treated with a few drops of magnesia mixture and again filtered. The reaction is then observed. If it be acid, the urine is simply heated to near the boiling point. If the urine be neutral or alkaline it is rendered faintly acid by the addition of dilute acetic acid, and heated. If albumin be present, a coagulum is formed, varying in quantity from a faint cloudiness to entire solidification, according to the quantity of albumin present. The coagulum is not redissolved upon the addi- tion of HN0 3 . Test for sugar: Render the urine strongly alkaline by addition of Na 2 C0 3 . Divide about 6 c.c. of the alkaline liquid in two test tubes. To one test tube add a very minute quantity of powdered subnitrate of bismuth, to the other as much powdered litharge. Boil the contents of both tubes. The presence of glucose is indicated by a dark or black color of the bismuth powder, the litharge retaining its natural color. Test for blood: To the urine add a solution of potassium hydroxide to distinct alkaline reaction ; heat nearly to boil- ing (do not boil). A red precipitate is produced. Test for bile pigment: Put 3 c.c. HN0 3 in atest tube, add a piece of wood, and heat until the acid is yellow; cool. When cold, float some of the urine to be tested upon the surface of the acid. A green band is formed at the junction of the liquid, which gradually rises, and is succeeded from below by blue, reddish-violet, and yellow. Test for indican: The urine is mixed with one-fifth its volume of 20 per cent, solution of lead acetate and filtered. 284 MEDICAL RECORD. The filtrate is mixed with an equal volume of fuming hydrochloric acid containing 3 : 1000 of ferric chloride, a few drops of chloroform are added, and the mixture strongly shaken one to two minutes. With normal urine the chloroform remains colorless, or almost so; but if an excess of indoxyl compounds be present the chloroform is colored blue, and the depth of the color is a rough in- dication of the degree of the excess. 3. Indications for the use of diuretics: (1) To remove excessive fluid from the tissues, as in dropsy; (2) to dilute the urine; (3) to promote the elimination of waste prod- ucts, or poisonous material from the blood; and (4) to maintain the action of the kidneys. 4. A tubercle is a small nodule, found in the lungs, etc., in cases of tuberculosis, but also found in other diseased conditions. It consists of three layers, the outer one con- sisting of lymphoid cells, the middle one of epitheloid cells, and the inner one of giant cells. These layers arc squeezed or compressed into a firm mass, which maj caseate or undergo other pathological processes. There is no blood supplied to a tubercle. Its origin is due to the stimulating or irritating effects of the tubercle bacillus upon the fixed connective tissue elements, causing a round- cell proliferation. The tissues most frequently invaded by it are: Lungs, lymphatic glands, bones, joints, intes- tinal tract, peritoneum, skin, testicle, epididymis, brain, liver, kidneys, spleen, Fallopian tubes, ovaries, uterus. 5. See French's "Practice" (1907), page 420; or Osier's "Practice (1909), page 267; or Rose and Carless' "Sur- gery" (1908), pages 144, 148, and 151; or Da Costa's "Sur- gery" (1908), pages 276, 279, and 284. 6. In carcinoma lymphatics are found in the stroma, which abounds; in sarcoma there are no lymphatics, but the blood vessels are in direct contact with the tumor cells. 7. Bacteria are classified as follows: (1) the coccus, which is spherical ; (2) the bacillus, which is rod-shaped ; and (3) the spirillum, which is spiral. 8. Cocci are classified as follows : Diplococci, occurring in pairs ; sarcinae, occurring in bales ; streptococci, occur- ring in chains ; and staphylococci, occuring in bundles. 9. The bacterium generally associated with specific urethritis is the gonococcus of Neisser. The gonococcus is a diplococcus, and is recognized by staining with the ordinary aniline dyes, being found inside the pus cells ; it is Gram negative, and can be cultivated on human blood serum, but will not grow on the ordinary culture media. 10. See Rose and Carless' "Surgery" (1908), page 1265. DIAGNOSIS AND THERAPEUTICS. i. Glaucoma is a diseased condition of the eye, pro- 28s MEDICAL RECORD. duced by increased intraocular pressure, and resulting in excavation and atrophy of the optic disc, and blindness. It is due to increase of the contents of the eye, hyper- secretion, retention, old age, gout, rheumatism, nephritis. Symptoms: Visual disturbances, increased ocular tension, hazy and anesthetic cornea, sluggish and dilated pupil, shallow anterior chamber, ciliary neuralgia, cupping of optic disc, blindness. Treatment: Myotics, such as eserine or pilocarpine; massage of the eyeball; mydriatics are contraindicated ; operative treatment may include para- centesis, iridectomy, or sclerotomy. 2. A delusion is a belief in something which has no real existence, but is purely imaginary, and out of which the person cannot be reasoned. An illusion is a false or per- verted impression, received through one of the senses. An hallucination is the same as an illusion, but without any material basis. If an individual believes himself to be made of glass, and is afraid of being touched lest he be broken, he is suffering from a delusion. If the whistling of the wind is mistaken for a voice telling a person to do a certain thing, that would be an illusion. If a person fancied he heard a voice when there was nothing at all to be heard, that would be an hallucination. 3. See French's "Practice" (1907), page 11 14; or, Osier's "Practice" (1909), page 1042. 4. See French's "Practice" (1907), page 893; or, Osier's "Practice" (1909), page 688. 5. Intestinal perforation in typhoid fever: Sometimes there is severe, sudden pain localized in the abdomen, and sometimes there is little or no pain. Marked tympanites, great weakness, collapse, anxious look, small, rapid' pulse, and difficult breathing are present. The legs are apt to be drawn up, and nausea and vomiting may ensue. Hepatic and splenic dullness appear, and leucocytosis may be present. The treatment is surgical ; laparotomy, with suture of the intestine, should be done as soon as possible. In the meantime opium (or preferably morphine) should be administered. 6. See French's "Practice" (1907), page 196; or, Osier's "Practice" (1909), page 209. 7. Treatment of abscess of the middle ear: Leeches, free incision followed by boric acid irrigation or by in- sufflation of dry boric acid powder. Complications that may arise: Eczema, boils, arthritis of temporo-maxillary joint, ankylosis or necrosis of the ossicles, facial paralysis, mastoiditis, subcranial abscess, meningitis, thrombosis of the lateral sinus, cerebral abscess. 8. Digitalis is indicated in diseases of the heart: (1) when the heart action is rapid and feeble, with low arte- 286 MEDICAL RECORD. rial tension; (2) in mitral lesions when compensation has begun to fail; (3) in non-valvular cardiac affections; (4) in irritable heart, due to nerve exhaustion. Digitalis is contraindicated in diseases of the heart: (1) in aortic lesions when uncombined with mitral lesions; (2) when the heart action is strong and arterial tension is high. 9. See French's "Practice" (1907), pages 935, 947, and 949; or, Osier's "Practice" (1909), pages 408, 424, and 425. 10. The patella reflex is nearly palways present in health, and denotes a healthy condition of the entire reflex arc (tendon, afferent or sensory nerve, posterior roots and anterior horn of the spinal cord, the efferent or motor nerve, and the muscle itself). It is absent when there is a lesion which affects any part of this reflex are, such as is the case in locomotor ataxia, poliomyelitis, Landry's par- alysis, neuritis, in apoplexy just after the shock, and in epilepsy following the convulsion, etc. It is exaggerated in : Hemiplegia, lateral sclerosis, general paresis, trans- verse myelitis, injuries to the spinal cord, hysteria, neu- rasthenia, tetanus, and strychnine poisoning. PEDIATRICS AND TOXICOLOGY. i. Tuberculosis of the nose: "Tuberculosis of the nose is characterized by the formation of neoplasms or ulcera- tion of the mucous membrane, and often accompanies a general pulmonic tuberculosis. Symptoms : In the ulcer- ated form there is an accumulation of crusts which are blown from the nose. There may be more or less stoppage of the nose, perforation of the septum, and nasal catarrh. In the neoplastic form, there is nasal obstruction and symptoms of hypertrophic catarrh. Treatment: In the necrotic form of the disease the nose should be sprayed twice daily with a mild alkaline spray, followed by an oil spray containing acetozone. Small papilla-like growths may be destroyed with the galvano-cautery or removed with snare and scissors. It is advisable to refrain as far as possible from surgical procedure in the nasal cavity in a general tuberculosis. The general treatment is directed to combating the tubercular infection by tonics, sunshine, and outdoor life." Tuberculosis of the ear. "Symptoms: The ear symp- toms frequently appear after the lung complications are established. There may be tinnitus, followed by deafness and painless rupture of the drum, and a thin mucous or mucopurulent discharge. On the other hand, the symptoms may vary in no wise from simple acute otitis media. Treatment: The surgical treatment is the same as for acute or chronic otitis media. Outdoor exercise and nutri- tive diet are especially essential." — (J. J. Kyle's Manual of Diseases of the Ear, Nose, and Throat.) 287 MEDICAL RECORD. Tuberculosis of the eye. " Tuberculosis of the con- junctiva: A rare condition, most frequently associated with lupus of the skin of the face. It is characterized by large, soft granulations in the fornices, studded with miliary tubercles. Usually there is some infiltration of the sclerocorneal margin and of the cornea, so that vision is reduced. Treatment is best effected by thorough re- moval of the granulations by scraping and subsequent in- sufflation with iodoform/' Tubercular iritis: Symptoms: "This is most frequently seen in children and young adults. It is of a quiet, painless, and chronic type. Miliary tuber- cles are to be seen in the iris — small grayish nodules, with a few pink vessels about them. They usually appear at the root of the iris, close into the angle of the anterior cham- ber, but may affect the border of the iris. Spots of lymph of large size, like spots of mutton fat, may be seen on the back of the cornea, indicating cyclitis. In other cases these symptoms may be complicated by a sclerokeratitis. These are of a more severe order, and shrinkage of the eyeball may result. The diagnosis of tubercle is not easy. We may exclude syphilis by history, by the balance of the symptoms, and by the response to treatment. The reac- tion to injection of Koch's tuberculin or the newer oph- thalmoreaction of Calmette may be utilized, or the aqueous may be tapped and inoculated into rabbits." — (Aids to Ophthalmology.) 2. Tuberculosis of the lymphatic glands occurs most commonly in people under twenty years of age; heredi- tary disposition and lowered vitality are predisposing fac- tors. The tubercle bacilli reach the glands either by the blood or lymph or through mucous membrane. The glands are enlarged and firm ; later they run together and caseate and frequently suppurate. Later still periadenitis fixes the mass to the deeper structures and to the skin. Still later the abscess bursts on the surface, leaving one or several openings and discharging pus for a long time. Treatment: Improve the general health by fresh air, sunshine, arsenic, cod liver oil, iron, and good nourishing food. The gland or whole glandular chain may be dissected out in cases where periadenitis is present. Where there is an unopened abscess, either excise and drain or dissect out. 3. See Rose and Carless' "Surgery" (1908), page 718; or, Da Costa's "Surgery" (1908), page 747. 4. Scabies is a contagious, animal, parasitic disease, due to the Sarcoptes scabiei, characterized by burrows and a multiform eruption, and attended by severe itching. The eruption usually occupies certain areas where the skin is thin; these are the interdigital spaces, the flexor surface of the wrist and arm, the anterior and posterior axillary folds, the mammae and nipples (in women), the umbilicus, 288 MEDICAL RECORD. the buttocks, the penis, the inner side of the thighs and legs, and the toes. The face is exempt except occasionally in infants. The itching is intense and worse at night. The affection is curable, but dermatitis may result from over- treatment. Treatment consists in a thorough scrubbing with soap and warm water, followed by friction to dry the skin, and the application of sulphur ointment, the latter to be repeated morning and night for three days. The whole process may need to be repeated one or more times. 5. Pemphigus is an acute or chronic inflammatory dis- ease of the skin, characterized by the formation of suc- cessive crops of variously sized, rounded or oval bullae affecting seriously the general health and sometimes termi- nating fatally. The blebs of pemphigus are tense, abruptly elevated, noninflammatory, and come out in crops. For Varicella, see French's "Practice" (1907), page 313; or, Osier's "Practice" (1909), page 128. 6. ''Acute catarrhal otitis media is frequently caused by acute coryza and the infectious fevers. There is a painless obstructed sensation in one or both ears, impairment of hearing, and tinnitus. The inflammation causes closure of the Eustachian tube. Inflation and aspiration of the middle ear and syringing and douching the nares and nasopharynx must be avoided. A moderate spray of Dobell's solution may be used. If pain is present, dry heat, in the form of hot-water bottle, hot stone wrapped in flannel, etc., may be applied. A few drops (100), warmed, of a carbolic acid solution (1:40), or one of formalin (1:2000), may be instilled into the ear. "Acute purulent otitis media: Acute catarrhal otitis media, instead of undergoing resolution, may pass into acute purulent otitis media (especially in exanthemas) from the passage of pathogenic germs from the naso- pharynx into the middle ear. The pain will become more intense, the hearing dull ; tinnitus will become louder and more distressing, and fever usually sets in. Dry heat allays the pain. Warmed water or warmed carbolic acid solution (1:40) may be used. Inflations, aspirations, etc., should be avoided. If the nares are filled with tough secre- tions, a spray of Dobell's solution may be used. If the pain continues over six hours in a child or over twelve hours in an adult without spontaneous perforation of the tympanic membrane, paracentesis of that structure should be performed. The concha and meatus should be smeared with petrolatum to avoid chapping, and the secretions should be gently mopped off as they appear. Under this treatment the ear usually returns to normal in two to three weeks." (Gould and Pyle's Pocket Cyclopedia of Medicine and Surgery.) 7. The patient will probably be found with pulse in- 289 MEDICAL RECORD. creased in frequency and fulness; the respirations more rapid, much general nervous excitement, and general hyper- esthesia. Empty the stomach, give stimulants; adrenalin is said to be antagonistic; nitroglycerine, amyl nitrite, am- monium carbonate and strychnine, and caffeine have all been recommended. Artificial respiration may be neces- sary; mustard plaster over the heart and stomach may give relief. 8. The patient is now probably in the stage of depres- sion, with shallow breathing, rapid heart action, and pale or cyanotic face. Chloroform or ether may be given sub- cutaneously, and the measures mentioned in question 7 may be adopted. 9. Alcohol (four to eight ounces of whiskey) followed by water is probably the best treatment when seen imme- diately. Later on some soluble sulphate, such as sodium sulphate or magnesium sulphate, is the proper treatment. 10. In poisoning by hydrocyanic acid, death is probably due to asphyxia ; by aconite, to asphyxia ; by morphine, usually to paralysis of respiration, occasionally to paraly- sis of the heart; by atropine, to paralysis of respiration; by strychnine, to fixation of respiratory muscles. SURGERY. 1. See Rose and Carless' "Surgery" (1908), page 926; or, Da Costa's "Surgery" (1908), page 773. 2. CHANCRE First lesion of a constitu- tional disease, viz., syphi- lis. Due to syphilitic infection. Generally a venereal infec- tion. May occur anywhere on the body. Period of incubation never so short as ten days. Generally single. Not autoinoculable. Secretion slight. Slightly or not at all pain- ful. As a rule only occurs once in any patient. Buboes are painless and seldom suppurate. CHANCROID A local disease. Due to contact with secre- tion from chancroid. Always a venereal infec- tion. Nearly always on genitals. Period of incubation al- ways less than ten days (generally about three). Generally multiple. Autoinoculable. Secretion profuse and pur- ulent. Generally painful. May reoccur in same pa- tient. Buboes are painful and usually suppurate. 290 MEDICAL RECORD. For treatment, see Rose and Carless' "Surgery" (1908), pages 157 and 141; or, Da Costa's "Surgery" (1908), pages 288 and 1 180. 3. Rose and Carless' "Surgery" (1908), page 526; or, Da Costa's "Surgery" (1908), page 505. 4. Nonunion of fracture is caused by: 111 health, want of approximation of the end of the bone, want of blood supply in the bone, defective innervation of the bone, dis- ease of the bone, lack of rest, and immobility. Treatment : "When delayed union exists, seek for a cause and remove it, treating constitutionally if required and thoroughly immobilize the parts by plaster. Orthopedic splints may be of value. Use of the limb while splinted, percussing over the fracture, and rubbing the fragments together, thus in each case producing irritation, have all been rec- ommended. Blistering the skin with iodine or firing it has been employed. If the case be very long delayed, forcibly separate the fragments and put in plaster as a fresh break. If these means fail, irritate by subcutaneous drilling or scraping, or, better, by laying open the parts and then drilling and scraping at many places." 5. Rose and Carless' "Surgery" (1908), pages 1134, 1 137, and 1 148; or, Da Costa's "Surgery" (1908), pages 1009 and 1012. 6. Ascites is caused by: Mechanical obstruction of the portal circulation; cardiac or pulmonary diseases ob- structing the general venous circulation; diseases of the peritoneum; diseases of the kidneys; anemia, debility, ex- posure to cold or wet; cancer, syphilis. Symptoms: Gen- erally of gradual onset; abdominal distention, sense of weight and fulness ; dyspnea ; gastrointestinal disturbances ; lineae albicantes, presence of fluid may be detected by pal- pation, percussion or aspiration. If due to heart or lung disease ascites will occur elsewhere, and the legs are gen- erally affected first; in hepatic disorders the abdominal distention is marked, and appears early; in renal disease the abdominal fluid is generally small in amount. Treat- ment: Tapping, drainage, incision, and administration of cathartics have all been recommended. Ovarian tumor, pregnancy, distended bladder, pancreatic cyst, and echi- ni ococcus cyst may be mistaken for it. Ascites is charac- terized by: Enlargement of the abdomen, most marked in the flanks when the patient is lying on his back, and in the hypogastrium, when he is standing up ; there are dilated superficial veins on the abdomen, and the skin is tense ; the umbilicus is prominent; there are fluctuation and vibration on palpation; dulness is found on percussion over the fluid, while the center of the abdomen is reso- nant. 291 MEDICAL RECORD 7. Rose and Carless' "Surgery" (1908), page 1173; or, Da Costa's "Surgery" (1908), page 11 10. 8. Prostatic hypertrophy is characterized by: Slowness in starting urination; difficult micturition; frequency of micturition, particularly at night; the presence of residual urine; dull, aching pain in the perineum and above the pubes; enlargement of the lateral lobes of the prostate; there may be cystitis and retention of urine. The cause: It is a senile change, and may be due to increase of the glandular substance or of the interstitial fibrous or mus- cular tissue. Palliative treatment consists in : Mild and unirritating diet, avoidance of alcohol, taking plenty of milk or water, .or other diluent. Alkalies and sedatives should be taken, also urotropin or other antiseptic so as to prevent cystitis. Regular catheterization, at least once a day, preferably in the evening, and with due aseptic pre- cautions. 9. Rose and Carless' "Surgery" (1908), pages 723 and 730; or, Da Costa's "Surgery" (1908), pages 151 and 156. OBSTETRICS AND GYNECOLOGY. i. See Williams' "Obstetrics" (1909), page 321 ; or, Hirst's "Obstetrics" (1909), page 329. 2. The second stage of labor begins when the os is fully dilated, and terminates with the expulsion of the child. Conditions which may cause delay are rigidity, edema, atresia, or displacement of the os or cervix; fibrous bands or atresia of vagina ; persistent hymen ; unyielding peri- neum ; tumors ; distended bladder or rectum ; hernia ; edema of labia; pelvic deformities; malpositions or mal- presentations of the fetus ; prolapse of limbs ; short cord ; large fetus; dead fetus; twins or monstrosities; uterine inertia; rupture of uterus. 3. Williams' "Obstetrics" (1909), page 507; or, Hirst's "Obstetrics" (1909), page 263. Preventive treatment: (1) The amount of nitrogenous food should be diminished to a minimum; (2) the pro- duction and absorption of poisonous materials in the intes- tines and body tissues should be limited and their elimi- nation should be aided by improving the action of the bowels, the kidneys, the liver, the skin, and the lungs ; v 3) the source of the fetal metabolic products and the periph- eral irritation in the uterus should, if necessar*, be removed by evacuating that organ. Curative treatment includes: (1) Controlling the convulsions (by chloroform, veratrum, or chloral) ; (2) elimination of the poison or poisons which are presumed to cause the convulsions; (3) emptying the uterus under deep anesthesia, by some method that is rapid and that will cause as little injury to the woman as possible. 292 MEDICAL RECORD 4. Endometritis is inflammation of the mucous mem- brane lining the uterus. The acute form is due to the introduction of septic bacteria, and is manifested by pain, constipation, irritability of bladder, rapid pulse, rise of temperature, and a profuse discharge. Treatment follow ing miscarriage or labor consists in curettage, intrauterine hot sterile douche, free purgation, hot stupes over the er abdomen, milk diet and stimulants. Chronic endo- metritis may accompany numerous pathological uterine conditions, but is generally due to gonorrhea. The symp- toms are backache, headache, leucorrhea, profuse men- struation, and impairment of the general health. Treat- ment consists in removing the cause when possible, and when due to gonorrhea curettage and irrigation of the uterus, with the application of an antiseptic. 5. See Williams' '"Obstetrics" (1909), page 737. 6. See Williams' "Obstetrics" (1909), page 842; or, Hirst's •'Obstetrics" (i909\ page 625. 7- VIRGIN" UTERUS The cavity is of normal length and triangular. The cervix is small, hard, and cartilaginous, and of the same length as the body. The external os is a trans- verse slit or pinhole ori- fice with smooth edges. The sides of the cavity of the body are convex in- ward. The uterus is normally anteflexed. There is more or less flat- tening of the anterior and posterior uterine surfaces. The fundus is nearly flat. The internal os is closed. UTERUS OF MULTIPARA The cavity is increased in length, and oval. The cervix is large and soft; it is about one-half the length of the body. The external os is irregular and its edges are fissured. The sides of the cavity of the body are convex out- ward. The uterus is straighter, or even retrodisplaced. The contour of the uterus is more rounded, while its diameters are increased. The fundus is convex. The internal os is patulous. (From Dorland's Obstetrics.) 8. 'Tears of the perineum destroy the integrity- of the pelvic floor and result eventually in rectocele, cystocele. hemorrhoids, and displacements of the pelvic organs. If the tear involves the sphincter ani, incontinence also results. Lacerations of the cervix retard or check involu- tion of the uterus and predispose to endometritis, menor- rhagia, displacements, eversion of the cervical mucous membrane, cystic degeneration, and malignant disease. 293 MEDICAL RECORD. Deep lacerations of the vaginal vault may open into the base of the broad ligaments, and in the majority of in- stances genitourinary fistulas are caused by traumatisms of labor. All lacerations are immediately dangerous on account of the increased liability to sepsis, while the remote results are generally due to interference with in- volution or the pelvic circulation and to the destruction of the normal supports of the pelvis." — (Ashton.) All tears should be repaired as soon as possible (unless there are contraindications). A primary operation is best because the edges are fresh and can be approximated; little (if any more) anesthetic is wanted; the woman has to lie in bed, and therefore only one absence from household work' is requisite; infection is less likely. - In any case, operation may prevent rectocele, cystocele, pro- lapse of uterus, and general weakness, malaise, and dis- ability. For technique, see any text-book on obstetrics or gynecology. ^ • l *\ g. Leucorrhea from the vagina is whitish in color, of a creamy consistency. When from the body of the uterus it is a thin, clear, watery, colorless fluid. From the cervix it is a clear, transparent, tenacious, glairy fluid, like white of egg. By means of a speculum the discharge can be seen coming from the uterus in the two latter conditions. 10. Symptoms: Pain and burning in the vulva and on micturition; dyspareunia; yellowish or greenish discharge containing the gonococcus; the vagina is hot, red, swollen, and tender. Possible results: Cystitis, urethritis, vulvitis, endometritis, salpingitis, septic peritonitis, sterility, condyl- omata of vulva, abscess of Bartholin's glands. STATE BOARD EXAMINATION QUESTIONS. Michigan State Board of Registration in Medicine. ANATOMY. i. Give the origin, insertion, and action of the rectus femoris. 2. Describe the scapula, and name the muscles attached to it. 3. Describe the collateral circulation after ligature of the common carotid artery. 4. Describe the inferior maxillary bone, and name the muscles attached to it. 5. Describe the deep palmar arch, and give its formation. 6. On examination of the under part of the brain, what structures and anatomical features will you observe? 7. Give the arterial and nerve supply of the pharynx, and mention the openings into it. 294 MEDICAL RECORD. 8. Describe the great superficial, petrosal nerve. 9. Describe the solar plexus and give its situation. 10. Describe the knee joint. HISTOLOGY AND EMBRYOLOGY. i. Describe the blood. 2. Does fetal blood and blood pressure differ from that of the mother? If so, how? 3. Describe the structure of the lungs. A. Give the histology of the thyroid gland. 5. Describe the kidney. PHYSIOLOGY. 1. What are the manifestations of cell life? Metabo- lism? Explain significance, and give classification. 2. Name the nerve centers which regulate intestinal peristalsis. Describe their action. 3. Name end products resulting from digestion of the three principal types of food, and explain how and by what channels they enter the circulation. 4. What is the physiological significance of the patellar reflex, and through what nerves is it accomplished? 5. Name the varieties of blood that circulate through the liver. State the source and give the function of each. 6. What purpose is served in boiling starchy foodstuffs, and when can a given amount be said to have been com- pletely digested? 7. Why do we breathe? What sounds are heard on listening to the chest? Where is the respiratory center located? 8. Give three examples illustrating the value of a knowl- edge of physiological chemistry. 9. Describe the special function possessed by each nerve factor concerned in a vasomotor action, and state how either affects arterial tension. 10. What changes take place in the composition of blood as it passes through the kidneys? CHEMISTRY AXD TOXICOLOGY. 1. Name the constituents of the atmosphere. Is air a mechanical mixture or a chemical combination of its con- stituents, and why? What part does carbonic acid play as regards vegetation? State the laws of gaseous diffusion. 2. Give the equations showing the action of sulphuretted hydrogen on solutions of copper sulphate and on alkaline hydroxide; also equations covering the production of car- bon dioxide. 3. What is the difference between atoms and molecules of the elements? What volume does the molecule occupy in the gaseous state? Give examples. 295 MEDICAL RECORD. 4. Give the characteristics of good drinking water, with method of determining same. 5. Name the more important of the petroleum products and their uses. 6. Name three aromatic hydrocarbons, with formulae. 7. Describe the groups of the compound proteids. 8. Give a list of the xanthin and creatinin groups of leucomaines. 9. Symptoms and treatment of poisoning by poison ivy. What active principle is involved? 10. Symptoms and treatment of poisoning by strychnine. MATERIA MEDIC A AND THERAPEUTICS. i. Name the toxic and physiological action of atropine and morphine. 2. What is the true and toxic action of calomel and iodide of potassium? 3. What are the potassium salts used in medicine? 4. What are depresso motors? Excito motors? Oxytox- ics? Mydriatics? Alteratives? Give examples of each class. 5. Give examples of drugs which affect the heart action, their doses, and principal actions. PATHOLOGY. 1. Mention some of the determining causes of disease. 2. Explain the effect of overfeeding upon the body. 3. Mention and define the forms of hemorrhage. 4. What constitutes fatty infiltration? Give etiology and favorite seats. 5. Describe the phenomena of inflammation in vascular tissues. 6. Osteoma : Give general appearance, seats, and struc- ture of. 7. Define glioma. Give its seats, minute structure, and nature. 8. By what term do we designate the destruction of red- blood cells? Give etiology. 9. Etiology and pathological anatomy of aneurysm. 10. What is the condition of the kidney in chronic in- terstitial nephritis? How is the urine affected? BACTERIOLOGY. 1. Describe the Bacillus typhosus, and briefly tell how you would differentiate it from Bacillus coli communis. 2. Describe fully the organism recognized as the cause of syphilis. 3. Define immunity, active and passive, natural and ac- quired. 296 MEDICAL RECORD. 4. Describe fully the different modes of multiplication in bacteria, and spore formation. 5. What are bacterial enzymes? PRACTICE OF MEDICINE. 1. Describe the characteristic symptoms and course of scarlet fever. 2. Discuss the diagnosis, symptoms, and treatment of whooping cough. 3. Discuss pericarditis and its treatment. 4. Describe a method of anesthesia you prefer for your patients. 5. Describe the symptoms present in: (a) Carcinoma of the stomach; (b) gastric ulcer; (c) duodenal ulcer. 6. Outline the management of a case of lobar pneu- monia. 7. Give in detail your advice to a young patient in the earliest stage of tuberculosis. 8. Mention some drugs which lower blood pressure, and give a theory of their action. 9. Give the therapy of acute cystitis. 10. Mention some complications which may follow ty- phoid fever. OBSTETRICS. 1. What is "hour-glass contraction"? How would you overcome it to remove adherent placenta? 2. Describe placenta prsevia, and how would you treat it during labor? 3. How would you manage a face presentation? 4. Give the cause, treatment of puerperal eclampsia, in- sanity, and septicemia. 5. How would you diagnose a shoulder presentation, and its correction? GYNECOLOGY. 1. Describe the uterus, its shape, dimensions, cavities, parts, openings, structure, lining, membranes, secretions, ligaments, nerves, etc. 2. Describe the vulvovaginal glands. 3. What are the causes of downward displacements of the uterus? 4. W T hat is the organ most frequently affected in tuber- culosis of the pelvis? 5. What are the symptoms of extrauterine gestation? SURGERY. i. Give the most approved methods of treatment of hem- orrhoids. 2. Describe fully the best method of procedure in case of recurring dislocation of the sternal end of the clavicle. 297 MEDICAL RECORD. 3. What signs and symptoms are always present in fractures? What are usually present? 4. Describe the best management of penetrating wounds of the skull caused t)y gunshot. 5. Give full description of operation of thyroidectomy. 6. Give the conditions under which resection of the bowel should be undertaken. 7. What is general anesthesia? How is it produced? What are the dangers to be avoided, and how? 8. Under what condition should the common carotid be ligated? Describe the operation. 9. What is surgical shock, and how would you relieve it? 10. Under what circumstances should appendicostomy be resorted to? Give technique of operation. HYGIENE. 1. What is the difference between disinfectants and ger- micides, and how do they severally act in preventing the spread of contagious and infectious materials. 2. What disease-carrying bacilli may be conveyed to the system by the ingestion of milk ? What are the microscopic characteristics of such bacilli? 3. Mention three satisfactory disinfectants, and give in- dications for their use. 4. What deleterious gases accumulate in imperfectly ven- tilated sleeping rooms? 5. Name five diseases requiring quarantine regulations, and state the time necessary for each. EYE, EAR, NOSE, AND THROAT. 1. Describe, in detail, how you would treat a chemical burn of the eyeball. 2. Give indications and contraindications for tracheotomy and intubation. 3. Give causes, symptoms, prognosis, and treatment of chronic suppurative otitis media. 4. Differentiate between trachoma and conjunctivitis. Give prognosis and treatment for trachoma. 5. Describe, in detail, the syphilitic conditions that may be found in the nose and throat. MEDICAL JURISPRUDENCE. i. Define: (a) Medical jurisprudence; (b) expert tes- timony; (c) civil malpractice; (d) criminal malpractice. 2. Give post-mortem appearances due to : (a) Asphyxia ; (b) drowning; (c) strangulation. 3. Describe a proper medical investigation in a suspected case of homicide. 4. How would you determine whether a wound or burn was inflicted before or after death? 298 MEDICAL RECORD 5. What is insanity? Distinguish between intellectual and moral insanity. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Michigan State Board of Registration in Medicine. anatomy. 1. Rectus femoris. Origin: Anterior inferior, spine of ilium; and groove above the brim of the acetabulum. In- sertion: Into the patella. Action: It helps to extend the leg upon the thigh and aids in supporting the pelvis and trunk upon the femur. 2. See Cunningham's "Anatomy" (1909), page 183; or Gray's "Anatomy" (1908), page 172. The muscles attached are: ^ Subscapularis, supraspinatus, infraspinatus, trapezius, deltoid, omohyoid, serratus magnus, levator anguli scapula?, rhomboids major and minor, triceps, teres major and minor, biceps, coraco-brachialis, and pectoralis minor. 3. After ligature of the common carotid artery the col- lateral circulation is: (1) The superior thyroid (of exter- nal carotid) with inferior thyroid (of subclavian) ; (2) the profunda cervicis (of subclavian) with the arteria princeps cervicis (of occipital) ; (3) the transversalis colli with the occipital; (4) branches of the two vertebrals, with branches of the two external carotids; (5) by the circle of Willis. 4. See Cunningham's "Anatomy" (1909), page 142; or Gray's "Anatomy" (1908), page 122. _ The muscles attached are: Levator menti, depressor labii inferioris, depressor anguli oris, platysma myoides, buccinator, masseter, orbi- cularis oris, geniohyoid, geniohyoglossus, mylohyoid, di- gastric, superior constrictor of pharynx, temporal, internal and external pterygoids. 5. See Cunningham's "Anatomy" (1909). page 836; or Gray's "Anatomy" (1908), page 660. 6. On the under surface of the brain there are: (1) In the middle line: Longitudinal fissure ; Rostrum and pedun- cles of corpus callosum; Lamina cinerea; optic commis- sure; Pitiutary body; Inf undibulum ; Tuber cinereum; Corpora albicantia; Posterior perforated space; Pons; Medulla. (2) On each side of the middle line: Frontal lobe; Olfactory bulb, tract, and roots; Anterior perforated space; Fissure of Sylvius; Optic tracts; Crusta; Tem- poral lobe; Hemisphere of cerebellum. 7. Pharynx. Arterial supply: Ascending pharyngeal, pterygopalatine, superior or descending palatine, superior thyroid, descending palatine, and tonsillar. Nerve supply: 299 MEDICAL RECORD. From pharyngeal plexus (from vagus, glossopharyngeal, and sympathetic) and from external and recurrent laryn- geal nerves. Openings: Two posterior nares, two Eusta- chian tubes, mouth, larynx, and esophagus. 8. See Cunningham's "Anatomy" (1909), page 687; or Gray's "Anatomy" (1908), page 1048. 9. See Cunningham's "Anatomy" (1909), page 712; or Gray's "Anatomy" (1908), page 1091. 10. See Cunningham's "Anatomy" (1909), page 297; or Gray's "Anatomy" (1908), page 336. HISTOLOGY AND EMBRYOLOGY. i. The blood is a fluid tissue composed of cellular ele- ments (red corpuscles, white corpuscles, and platelets) and intercellular substance, or liquor sanguinis, or plasma. The red blood corpuscles are biconcave discs, about 1-3200 of an inch in diameter; they are nonnucleated, and there are about 4,500,000 or 5,000,000 of them in each cubic milli- meter of blood. They are elastic and soft, and their shape is changed by pressure, but is promptly regained on the removal of the pressure. Their color is yellowish. They contain hemoglobin. The leucocytes, or white blood cells, are spheroidal masses, varying in size, having no cell wall, and containing one or more nuclei; there are about 7,000 to 10,000 of them in each cubic millimeter of blood. They differ much in appear- ance, and are divided into : ( 1 ) small mononuclear leuco- cytes, or lymphocytes, (2) large mononuclear, (3) transi- tional, (4) polynuclear, or polymorphonuclear, or neutro- phile, and (5) eosinophile. They are all more or less granular, particularly the last two varieties named. They are probably formed in the spleen, lymphatic glands, and lymphoid tissues. Their fate is uncertain; it has been asserted that they are converted into red blood cells; they play a part in the formation of fibrin ferment; they are sometimes converted into pus cells. The platelets are very small, colorless, irregularly shaped bodies; about one-fourth the diameter of a red cell. They vary in number from 200,000 to more than 500,000 per cubic millimeter. 2. Fetal blood has a lower specific gravity; the red cells vary greatly in size and shape, are nucleated, and are defi- cient in hemoglobin ; the white cells have a different pro- portion of their various kinds, the mononuclears prepon- derating. Wth regard to fetal blood pressure, nothing definite is known. 3. See Cunningham's "Anatomy" (1909), page 990; or Gray's "Anatomy" (1908), page 1403. 4. See Cunningham's "Anatomy" (1909), page 1217; or Gray's "Anatomy" (1908), page 1409. 300 MEDICAL RECORD. 5. See Cunningham's "Anatomy'' (1909), page 1138; or Gray's "Anatomy" (1908), page 1426. * PHYSIOLOGY. 1. The manifestations of cell life are: Movement, inges- tion, assimilation, excretion, growth, irritability, and re- production. Metabolism is the entire series of changes that occur in a cell or organism during the processes of nutrition. It is of two kinds: (1) Assimilative, or con- structive (anabolism) ; and (2) destructive (katabolism). 2. Intestinal peristalsis is regulated by: (1) The vagus, which stimulates; and (2) branches of the sympathetic system, by the solar and lumbar plexuses, and the splanch- nics; the effect of the sympathetic system is inhibition. (3) The role of the plexuses of Auerbach and Meissner is not known. 3. Proteids are converted into proteoses and peptones in the stomach, and in the small intestine (by the action of pepsin and trypsin, respectively). Carbohydrates are converted (slightly) into dextrin and sugar in the mouth, by the action of the ptyalin of the saliva ; also in the small intestine (by the action of amy lop- sin) into maltose. Fats are emulsified and saponified in the small intestine by the action of steapsin. Bile also has some slight effect on starches and fat. The products of digestion find their way into the blood by two routes: (1) By the blood-vessels of the gastroin- testinal tract, which unite to form the portal vein, and (2) by the lymph vessels of the small intestine, which converge to empty into the thoracic duct. The water, inorganic salts, proteids, and sugar go by way of the portal vein to the ascending vena cava; the fats go by way of the thoracic duct to the junction of the left subclavian and internal jugular veins. 4. The patellar reflex is generally present in health. The afferent nerve is the anterior crural: the efferent nerve is also the anterior crural. 5. In the liver there is the blood in: (1) The hepatic artery (branch of celiac axis) which supplies Glisson's capsule, walls of the bile ducts, and in general serves for the nutrition of the organ. (2) The hepatic rein, which empties into the inferior vena cava: it arises in the liver, and takes the blood away from the liver. (3) The portal vein, which takes the absorbed products of digestion from the gastric, splenic, superior mesenteric, and inferior mesen- teric veins to the liver. 6. Boiling breaks the starch grains, bursting the cellulose, and thus allowing the digestive juices to come more readily 301 MEDICAL RECORD. in contact with the granulose. The conversion of the starch into sugar takes place more rapidly. A given amount of starch may be said to have been com- pletely digested when no starch is left? it having all been converted into sugar. In the test tube this can be ascer- tained by the iodin test showing the absence of starch, and Fehling's test showing the presence of sugar. 7. The object of respiration is the interchange of gases in the lungs, so that oxygen may be introduced and carried to the tissues, and carbon dioxide may be expelled from the body. Two respiratory sounds are heard on listening to the chest, the inspiratory and expiratory. The respi- ratory center is located in the medulla. 8. Three examples of value of knowledge of physiolog- ical chemistry: (1) That albumin is coagulated by heat; (2) that glucose will reduce alkaline copper sulphate so- lution; (3) that pepsin will only exert its proteolytic action in an acid medium. 9. The nerves concerned in a vasomotor action are: (1) The vasoconstrictor, which causes constriction of the blood- vessels and increase blood pressure; and (2) the vaso- dilator, which causes dilatation of the vessels by inhibiting the action of the vasoconstrictors, and lower blood pres- sure. 10. As the blood passes through the kidneys it loses: Water, salts, urea, carbon dioxide, and extractives. CHEMISTRY AND TOXICOLOGY. i. The constituents of the atmosphere are : Oxygen, ni- trogen, carbon dioxide, water vapor, ammonia, argon, etc. Air is a mixture, and not a definite chemical compound. Proof: (1) The composition is not constant; (2) the pro- portion of its constituents bears no relation to their atomic weights; (3) when air is absorbed by water and then ex- pelled, the ratio of the nitrogen and oxygen is not the same as in the original air ; (4) when oxygen and nitrogen are brought together in proper proportions there is no chemical action, nor is heat given off or absorbed, and yet the resulting mixture has all the properties of air. Carbon dioxide is the food of vegetables, and is by them utilized for the building up of complex organic compounds. Diffusion of gases: If two gases be brought in contact with each other they will quickly mingle so as to make. a uniform mixture. A similar diffusion will take place if they are separated by a porous membrane or partition. Graham's law of diffusion is : The velocity of diffusion of different gases is inversely proportional to the square roots of their densities. 2. H 2 S + CuSO* = CuS + H 2 S0 4 H 2 S + KHO == H2O + KHS 302 MEDICAL RECORD, CaC0 3 + 2HCI = CaCl 2 + C0 2 + H 2 2NaHC0 3 + heat = Na 2 C0 3 + C0 2 + H 2 2CO + 2 = 2 C0 2 3. An atom of an element is the smallest particle of that element which can enter or leave a chemical reaction. A molecule of an element is the smallest particle of that ele- ment which can exist free. The formula weight of the molecule of a gas in grams occupies a volume of 22.4 liters. Thus 2 represents 32 grams of oxygen, which will occupy 22.4 liters; and NH 3 represents 17 grams of ammonia, which will also occupy 22.4 liters. 4. Characteristics of a good drinking water: (1) It should be clear and limpid. Cloudy and muddy waters should be avoided. (2) It should be colorless. A greenish or yel- lowish color is usually due to vegetable or animal matter in solution or to organisms. (3) It should be odorless; especially free from sulphuretted hydrogen or putrefactive animal matter. (4) It should not be too cold, but should have a temperature of from 46 ° F. to 6o° F. (5) It should have an^ agreeable taste ; neither flat, salty, nor sweetish. A certain amount of hardness and dissolved gases give a sparkling taste. It should contain from 25 to 50 c.c. of gases per liter, of which 8 to 10 per cent, is carbon dioxide and the rest oxygen and nitrogen. (6) It should be as free as possible from dissolved organic matter, especially of animal origin. (7) It should not contain too great an amount of hardness. A certain quantity of saline matter is necessary, however, to give it a good taste. It should not contain over three or four parts of chlorine in 100,000 parts of water. — (From Bartley's Chemistry.) 5. Petroleum products: Cymogene (used in ice ma- chines) ; rhigolene (used to produce cold, and as an anes- thetic) ; gasolene and petroleum ether (used for making "air gas") ; naphtha (used as a solvent for fats and rub- ber) ; benzine (used for varnishes and paints) ; kerosene (used for illuminating purposes) ; lubricating oil (for lubri- cating machinery) ; paraffiin (for making candles). 6. Three aromatic hydrocarbons: (1) Benzene C 8 H 6 ; (2) Phenol, C 6 H 5 OH ; (3) Salicylic acid, C 6 H 4 OH, # COOH. 7. Compound proteids are composed of a single proteid united to some non-proteid body. The chief groups are : (a) Hemoglobins — decomposable into an albumin and a crystalline pigment or chromogen. (b) Nucleoproteids — yield nucleic acids and native albumins on decomposition. Nucleohiston, etc. (c) Glycoproteids — decomposable into a reducing substance and a native albumin. Mucin, mucoids, phosphoglycoproteids. 8. Xanthin group of leucomaines: Adenin, hypoxanthin, guanin, xanthin, heteroxanthin, paraxanthin, carnin, pseudo- 303 MEDICAL RECORD. xanthin, spermin. Creatinin group of leucomaines: Creatin, creatinin, xanthrocreatinin, crusocreatinin, amphicreatinin. 9. Poison ivy, Symptoms of poisoning: "When ap- plied to the skin it causes, after a few hours, an intense itching and burning, followed by swelling of the skin of the affected parts, with papular eruption or slight vesica- tion, terminating after a few days in desquamation." Treatment : "An alcoholic solution of lead acetate usually gives prompt relief. If itching is severe it may be com- bined with opium. Painting the parts with ichthyol is successful with many, as is the application of fluid extract of grindelia robusta. Weak alkaline solutions have given excellent results. "7- ( Riley's Toxicology.) The active principle is toxicodendron 10. Symptoms of poisoning by strychnine: A sense of suffocation, thirst, tetanic spasms, usually opisthotonos sometimes emprosthotonos, occasionally vomiting, contrac- tion of the pupils during the spasms, and death, either by asphyxia during a paroxysm, or by exhaustion during a remission. The symptoms appear in from a few minutes to an hour after taking the poison, usually in less than twenty minutes ; and death in from five minutes to six hours, usually within two hours. Treatment: "The con- vulsions are to be arrested or mitigated by bringing the patient under the influence of chloral or chloroform as rapidly as possible; the stomach is to be washed out, and the patient is to be kept as quiet as possible." (Witthaus' Essentials of Chemistry.) PATHOLOGY. 1. Determining causes of disease: Traumatism, tempera- ture (heat, cold, burns), electricity, environment, poisons, autointoxication, food, parasites, and micro-organisms. 2. Effect of overfeeding : Indigestion, disturbed metab- olism, increase of urea, increase of fat or glycogen, obesity, fatty infiltration or degeneration, gout, diabetes, anemia. 3. Hemorrhage is the escape of all the constituents of the blood from the heart or blood-vessels. Forms: Ac- cording to the source of the flow, it may be cardiac, ar- terial, venous, or capillary. ^ Arterial hemorrhages may be primary (occurring at the time of injury), intermediate or reactionary (occurring within twenty-four hours of the in- jury), and secondary (occurring later, even some days after the injury). Petechia are minute, circumscribed hemorrhages, generally subcutaneous ; when larger, they are called ecchymoses, or extravasation, or sugillation; a hema- toma is a collection of blood in a solid tissue. 4. Fatty infiltration consists in the deposition of fat from the circulation between the cells of which a tissue is composed. Etiology: Heredity, excessive nutrition, diges- 304 MEDICAL RECORD. tive disorders, lack of exercise, anemia, alcohol, diminished oxidation, high external temperature. Seats: Beneath skin and serous membranes, in the fasciae, in areolar connective tissue, mesentery, omentum, liver, heart, and kidneys. 5. See Rose and Carless' "Surgery" (1908), page 31; or Da Costa's "Surgery" (1908), pages j$ and 76. 6. Osteoma. General appearance : There are two forms, exostoses and osteoma proper. The former has its sur- face irregular and nodular, and has the consistency of bone. The latter is more rounded and lobulated. Seats: Bone> cartilage, connective tissue near the bones, serous membranes, and organs such as parotid gland and testicle. Structure: Osteoma resembles bone tissue, but cartilage is apt to be mixed with it. Softening and other secondary degenerative changes may occur, and other tumors are apt to be associated with it (chondroma, fibroma, and sar- coma). 7. Glioma. Seats: Brain, spinal cord, and retina. Struc- ture: It consists of cells containing rounded or oval nuclei, with very little protoplasm, and fine protoplasmic extensions which interlace and form an intercellular reticulum, giving a granular appearance. The number of the cells and the density of the intercellular network vary. As a rule, the cells are larger than # neuroglia cells, and sometimes they contain several nuclei. The tumor is generally quite vas- cular, and occasionally teleangiectatic vessels may be ob- served. Nature: It is benign, but dangerous, on account of pressure; growth is slow, but it may become sarcoma- tous. — (From Stengel's Pathology.) 8. Destruction of red blood cells is called : Hemocytoly- sis, or hemolysis. Etiology: It occurs in the liver; it may result from burns, also from infections and toxic agents (such as potassium chlorate) ; malaria, pneumonia, and other diseases may cause it. 9. See Rose and Carless' "Surgery" (1908), page 307; or Da Costa's "Surgery" (1908), pages 359 and 356. 10. See French's "Practice of Medicine" (1907), pages 902 and 903; or Osier's "Practice of Medicine" (1909), pages 695 and 697. BACTERIOLOGY. 1. Bacillus typhosus is a rod-shaped organism, with rounded ends, is from 2 to 4 microns in length, and about three-fourths of a micron in breadth; it does not stain by Gram's method, but stains with all the anilin dyes ; it has flagella, no spores, is aerobic and facultative anaerobic, and is motile. * To distinguish the typhoid bacillus from the colon bacil- lus: (1) On gelatin plates, the colonies of typhoid develop more slowly than those of colon bacillus. (2) The colon bacillus causes fermentation with production of gas in 305 MEDICAL RECORD. media which contain sugar; the typhoid bacillus does not. (3) The colon bacillus produces a strong acid reaction and coagulates milk within twenty-four to forty-eight hours; the typhoid bacillus does not coagulate milk. (4) In pep- tone solution the colon bacillus produces indol ; the typhoid bacillus does not. (5) The typhoid bacillus gives the Widal reaction with typhoid serum ; the colon bacillus does not. 2. The cause of syphilis is the treponema pallidum. It is a very slender spiral, about 4 to 20 microns in length, with very close and regular turns, the curves vary in number from three or four to twelve or twenty. At each pole is a fine flagellum. It can move forward and back- ward, and also rotate on its axis. It is not settled whether division is transverse or longitudinal. It has not yet been cultivated on artificial media. 3. Immunity is the power of resistance of cells and tis- sues to the action of pathogenic bacteria. Immunity may be either natural or acquired. Natural immunity is this power of resistance, natural and inherited, and peculiar to certain groups of animals, but common to every individual of these groups. Acquired immunity is this resistance acquired: (1) By a previous attack of the disease caused by the bacteria, or (2) by the person being made artificially insusceptible. The conditions which give immunity from the pathogenic action of bacteria are: (1) A previous attack of the dis- ease; (2) inoculation, with small quantities of bacteria, so as to produce a mild attack of the disease; (3) vaccination; (4) the introduction of antitoxins; (5) the introduction of the toxins of the bacteria. Active immunity follows an attack of^ a certain disease and secures immunity for that alone ; or it f ollcws inocula- tion of a virus weaker than necessary to cause the typical disease ; or it follows inoculation by bacterial products apart from the organisms themselves. Passive immunity is the term applied to the effect of a serum derived from an immunized animal and injected into one not immune. 4. Bacteria multiply by fission. A bacterium about to divide seems to be larger than normal, and if it is a coccus it becomes more ovoid; changes occur first in the nucleus, and the bacterium just falls in two. It has been calculated that a single bacterium could, by fission, produce two in one hour. Fortunately, they seldom obtain food enough to keep up this process for any length of time. Spore formation is not so much a method of multiplica- tion as of continuance of the life of the individual bacterial cell ; it is a process by which the organism enters a stage in which it can better resist certain deleterious influences, such as high temperature, desiccation, lack of nutrition. 306 MEDICAL RECORD. It occurs chiefly in bacilli. There are two forms : Endo- spores and arthrospores. The former are true spores. 5. Bacterial enzymes are enzymes or ferments produced by bacteria, and which cause certain of the chemical ef- fects supposed to be due to the bacteria. The curdling of milk is due to a bacterial enzyme rather than to a micro- organism directly. PRACTICE OF MEDICINE. i. See French's "Practice of Medicine" (1907), page 317; or Osier's "Practice of Medicine" (1909), page 132. 2. See French's "Practice of Medicine" (1907), page 202; or Osier's "Practice of Medicine" (1909), page 149. 3. See French's "Practice of Medicine" (1907), page 557; or Osier's "Practice of Medicine" (1909), page 775. 4. See Rose and Carless' "Surgery" (1908), page 1323; or Da Costa's "Surgery" (1908), page 1031. 5. Gastric ulcer is generally caused by injury or bacteria, is most apt to occur between the ages of twenty and forty- five; after eating there is pain localized in the stomach, vomiting occurs soon after eating, hematemesis is com- mon, there is localized tenderness over the stomach, and examination of the gastric contents shows an excess of free HC1. Gastric carcinoma does not usually occur before forty years of age, is more common in males, the pain is localized and constant, vomiting is copious and occurs some time after eating; the vomitus contains "coffee ground" mate- rial ; hemorrhages are common ; a tumor may be palpated, and examination of the gastric contents shows absence of free HC1 and presence of lactic acid; severe anemia and cachexia are also present. In duodenal ulcer the pain is apt to be more to the right, and to occur at an interval of two or three hours after meals ; the hemorrhages will be intestinal, and the blood will be passed by way of the bowels, and not vomited. In many cases the symptoms are identical with those of gastric ulcer. 6. See French's "Practice of Medicine" (1907), page 174; or Osier's "Practice of Medicine" (1909), page 189. 7. See French's "Practice of Medicine" (1907), page 391 ; or Osier's "Practice of Medicine" (1909), page 352. 8. Drugs which lower blood pressure: Amyl nitrite, so- dium nitrite, spirit of nitrous ether, nitroglycerin. They act by producing dilatation of the blood-vessels. 9. See Rose and Carless' "Surgery" (1908), page 1192; or Da Costa's "Surgery" (1908), page 1135. 10. Complications which may follow typhoid fever: Re- lapses, indigestion, constipation, diarrhea, perforation of intestine, peritonitis, hepatic abscess, cholecystitis, gall- 307 MEDICAL RECORD stones, hypertrophy of spleen, paralysis, typhoid spine, neuritis. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), page 664. 2. See Williams' "Obstetrics" (1909), pages 809 and 815; or Hirst's "Obstetrics" (1909), pages 572 and 577. 3. If the chin is presenting anteriorly, expectant treat- ment may suffice; but care must be taken to observe that the chin does not rotate backward. Spontaneous version may occur, and the presentation becomes a vertex one. Failing this, or as a means of favoring this, postural treat- ment, such as Walcher's position, has been recommended. If, in spite of this, engagement has not occurred, cephalic version is indicated, care being taken not to rupture the membranes. If this is not successful, podalic version should be tried. If, after all these manipulations the child is still alive and the head is engaged, symphyseotomy is in- dicated; if the child is dead, craniotomy should be per- formed. 4. Puerperal eclampsia. The causes may be : Uremia, albuminuria, imperfect elimination of carbon dioxide by the lungs, medicinal poisons, septic infection; predisposing causes are renal disease, and imperfect elimination of the skin, bowels, and kidneys. The line of treatment laid down by Edgar is as follows: For preventive treatment: (1) The amount of nitrogenous food should be diminished to a minimum; (2) the production and absorption of poison- ous materials in the intestines and body tissues should be limited and their elimination should be aided by improving the action of the bowels, the kidneys, the liver, the skin, and the lungs; (3) the source of the fetal metabolic prod- ucts and the peripheral irritation in the uterus should, if necessary, be removed by evacuating that organ. The curative treatment includes: (1) Controlling the convul- sions (by chloroform, veratrum, or chloral) ; (2) elimina- tion of the poison or poisons which are presumed to cause the convulsions; (3) emptying the uterus under deep anes- thesia, by some method that is rapid and that will cause as little injury to the woman as possible. And see Williams' "Obstetrics" (1909), pages 915 and 852; or Hirst's "Obstetrics" (1909), pages 256 and 764. 5. See Williams' "Obstetrics" (1909), pages 799 and 802; or Hirst's "Obstetrics" (1909), pages 426 and 433. GYNECOLOGY. 1. See Cunningham's "Anatomy" (1909), page 1187; or Gray's "Anatomy" (1908), page 1498. 2. See Cunningham's "Anatomy" (1909), page 1198; or Gray's "Anatomy" (1908), page 1495. 308 MEDICAL RECORD. 3. Causes of downward displacements of the uterus ; (i) Pressure from above ^ (pelvic or abdominal tumors, ascites, tight or heavy clothing, straining at stool, musculaf exertion, fecal accumulations, habitual overdistention of the bladder) ; (2) weakening and relaxation of the uterine sup ports (subinvolution, senile atrophy of pelvic floor, abnor mally large pelvis, increased weight of uterus, puerperal traumatisms, pressure from above, traction from below) ; (3) increased weight of uterus (congestion, subinvolution, metritis, pregnancy, fluid in the endometrium, uterine tu- mors) ; (4) traction from below (vaginal cicatrices, falling of pelvic floor, contraction and congenital shortening of vagina, tumors of cervix or vagina). — (From Dudley's Gynecology.) 4. In tuberculosis of the pelvis the organ most frequently affected is the Fallopian tube. 5. "When extrauterine pregnancy exists there are: (1) The general and reflex symptoms of pregnancy; they have often come on after an uncertain period of sterility ; nausea and vomiting appear aggravated. (2) Then comes a dis- ordered menstruation, especially metrorrhagia, accompanied with gushes of blood, and with pelvic pain coincident with the above symptoms of pregnancy; pains are often very severe, with marked tenderness within the pelvis; such symptoms are highly suggestive. (3) There is the presence of a pelvic tumor characterized as a tense cyst, sensitive to the touch, actively pulsating; this tumor has a steady and progressive growth. In the first two months it has the size of a pigeon's egg; in the third month it has the size of a hen's egg; in the fourth month it has the size of two fists. (4) The os uteri is patulous; the uterus is displaced, but is slightly enlarged and empty. (5) Symptoms No. 2 may be absent until the end of the third month, when sud- denly they become severe, with spasmodic pains, followed by the general symptoms of collapse. (6) Expulsion of the decidua in part or whole Nos. 1 and 2 are presumptive signs; Nos. 3 and 4 are probable signs; Nos. 5 and 6 are positive signs." — (American Text-Book of Obstetrics.) . surgery. 1. See Rose and Carless' "Surgery" (1908), pages 1145 and 1151; or Da Costa's "Surgery" (1908), page 1014. 2. See Rose and Carless' "Surgery" (1908), page 618; or Da Costa's "Surgery" (1908), page 586. 3. See Rose and Carless' "Surgery" (1908), page 470; or Da Costa's "Surgery" (1908), page 435- 4. See Rose and Carless' "Surgery" (1908), page 751; or Da Costa's "Surgery" (1908), page 712. 5. See Rose and Carless' "Surgery" (1908), page 900; or Da Costa's "Surgery" (1908), page 1072. 309 MEDICAL RECORD. 6. Indications for resection of bowel: Strictures of in- testine, gangrene of intestine, extensive injury of intestine, tumors of intestine, tuberculosis of intestine, injury to the vessels supplying intestines, some cases of intussusception, and artificial anus. 7. See Rose and Carless' "Surgery" (1908), page 1325; or Da Costa's "Surgery" (1908), page 1034. 8. Indications for ligature of common carotid: Wounds of either common carotid, external carotid, or internal carotid (and branches of the two latter); in aneurysms; to limit the growth of inoperable tumors; as a temporary procedure. For the operation, see Rose and Carless' "Sur- gery" (1908), page 331; or Da Costa's "Surgery" (1908), page 415. 9. Shock is the name given to a sudden and general de- pression of the vital powers, due to some strong stimula- tion (such as injury or emotion) acting on the vital centers in the medulla, and producing vasomotor paralysis. Treat- ment: Place the patient in the recumbent position, with the head low; apply warmth to the body; administer a stimu- lant, and give a hot saline infusion; morphine, hypoder- matically, may be necessary for the relief of pain. 10. Appendic ostomy is performed to irrigate the colon in cases of chronic ulcerative colitis or chronic dysentery, and in chronic constipation. For technique of the opera- tion, see Da Costa's "Surgery" (1908), page 916. HYGIENE. 1. Disinfectants are agents which restrain infectious dis- eases by destroying or removing their specific poisons ; some are germicides, as chlorine; others act by dilution or removal, as soap and water, and fresh air. Germicides are agents which destroy bacteria and their germs. 2. The following disease-carrying bacilli may be con- veyed by milk : Tubercle bacillus, Klebs-Loeffler bacillus of diphtheria, typhoid bacillus, cholera bacillus. The tubercle bacillus is rod shaped, is from 1^ to 3^ microns in length, and about one-third to one-half a micron in breadth, is a strict parasite, is not motile, and has no flagella. It is slightly curved, does not form spores, is not liquefying, is aerobic and nonchromogenic ; it resists acids; it grows well on blood serum; stains well by Ehrlich's, Ziehl-Nielsen's, or Gabbett's method; it is Gram-positive. The bacillus of diphtheria is from 2 to 6 microns in length and from 0.2 to 1.0 micron in breadth; is slightly curved, and often has clubbed and rounded ends; occurs either singly or in pairs, or in irregular groups, but does not form chains; it has no flagella, is nonmotile, and aerobic; is noted for its pleomorphism ; it does not stain 310 MEDICAL RECORD. uniformly, but stains well by Gram's method and very beautifully with Loeffler's alkaline-methylene blue. The typhoid bacillus is a rod-shaped organism, with rounded ends, is from 2 to 4 microns in length, and about three-fourths of a micron in breadth; it does not stain by Gram's method, but stains with all the anilin dyes; it has flagella, no spores, is aerobic and facultative anaerobic, and is motile. The cholera bacillus is a spirillum, actively motile, and with a flagellum at one end ; it is curved, has rounded ends, and is about half the length of the tubercle bacillus; it stains readily with ordinary anilin stains, but not by Gram's method; it is easily cultivated on the usual media; it has but slight power of resistance; it liquefies gelatin, and does not produce pigment. 3. Burning is the best disinfectant; then moist heat and dry heat; carbolic acid and mercury bichloride are excel- lent except in the presence of albuminous material, when chloride of lime or formalin are better; formaldehyde and sulphur dioxide are both good disinfectants. 4. Carbon dioxide; crowd poison; volatile matters from foul mouths, decayed teeth, and the digestive tract; aqueous vapor from the respiration and skin; products of combus- tion of illuminating substances. 5. Five quarantinable diseases: Cholera, yellow fever, smallpox, plague, typhus. For length of time, see index to these diseases in French's or Osier's "Practice." 7 EYE, EAR, NOSE, AND THROAT. i. For chemical bums of the eyeball: The treatment con- sists in the complete removal of the caustic substance as soon as possible. Solid particles are removed with cotton or forceps. Then the conjunctival sac is washed out with solutions which tend to neutralize the corrosive substance or render it insoluble. In the case of lime, mortar, or caustic alkalies, we flush out with a solution of boric acid; or we may wash out the eye with oil. If the corrosive agent consisted of an acid, the eye is irrigated with a weak solution of sodium bicarbonate. Subsequently we use cold compresses, atropine, and sometimes a bandage. After the loosening of the eschars, we must separate the adhesions frequently. Symblepharon often occurs notwith- standing the greatest care." — (May's Diseases of the Eye.) 2. Tracheotomy is indicated in diphtheria when intuba- tion does not relieve and the symptoms are urgent; to re- move foreign bodies from the larynx that cannot be treated by simple methods ; to provide passage for air, in growths, tumors, or abscesses pressing on the larynx and interfer- ing with the proper supply of air; and for edema of the glottis when the intubation tube cannot be introduced. 311 MEDICAL RECORD. Intubation is indicated in any obstruction of the larynx which prevents a sufficient amount of air from entering the lungs, such as croup, edema of the glottis, spasm of the larynx, any form of paralysis that lessens the lumen of the larynx, chronic stenosis. Intubation is not indicated for the removal of a foreign body, nor for any obstruction too far down to be reached by the shaft of the tube. 3. See Rose and Carless' "Surgery" (1908), page 882. 4. In conjunctivitis there are no granules with subsequent cicatricial changes. Trachoma is an inflammatory condition of the conjunc- tiva, accompanied by hypertrophy, granule formation, and subsequent cicatricial changes. Treatment "consists in an attempt to reduce the inflam- matory symptoms and secretion, and to check and remove hypertrophy of the conjunctiva, thus shortening the dura- tion and diminishing the liability to conjunctival cicatriza- tion and to sequelae. This is accomplished either by the use of certain irritating applications, or by mechanical (sur- gical) means. Irritating applications: Sulphate of copper in the form- of a crystal or pencil is the favorite local ap- plication. Nitrate of silver (1 or 2 per cent, solution), gylcerole of tannin (5 to 25 per cent.), and the alum stick are also employed. Mechanical {surgical) treatment in- cludes expression, grattage, excision, curetting, electrolysis, #-rays, and galvano-cautery." — (May's Diseases of the Eye.) Prognosis is not favorable; the condition may last for years, and complete recovery is not common. 5. See Rose and Carless' "Surgery" (1908), pages 822, 830, and 871. MEDICAL JURISPRUDENCE. r. Medical jurisprudence is the application of the knowl- edge of any of the branches of medicine to the problems and reauirements of the law. In expert testimony the witness may give his opinion on facts or supposed facts as noted by himself or asserted by others. Theoretically this can be clone only by those perfectly familiar with the subject in question; but prac- tically any (or almost any) physician with a license to practise is accepted as an expert witness. In ordinary testimony the witness testifies only to facts which he has seen, or heard, or with which he has become acquainted by personal observation. Malpractice is a failure on the part of a medical practi- tioner to use such skill, care, and judgment in the treat- ment of a patient as the law requires; and thereby the patient suffers damage. If due to negligence only, it is civil malpractice. But if done deliberately, or wrongfully, 312 MEDICAL RECORD, or if gross carelessness or neglect have been shown, or if some illegal operation (such as criminal abortion) be per- formed, it is criminal malpractice. 2. In death by ^ asphyxia: Very commonly punctate ecchymoses are visible on the conjunctiva, face, neck, and chest. They are considered by Tardieu to be more frequent in strangulation than in asphyxia from other causes, or than in cases of overstraining, which likewise may lead to them. In the subcutaneous cellular tissue, and in the fascia of the muscles above and below the hyoid bone extravasa- tions are frequently found, as well as on the external sur- face of the thyroid cartilage and trachea. The lungs vary as regards their vascularity; but on the surface it is com- mon to find pseudomembranous patches, which are due to the rupture of some of the superficial air cells and collec- tion of air bubbles under the pleura. In the substance of the lungs congested patches, or apoplectic extravasations, are often found, varying in size, but larger than those usually found in suffocation. In death by drowning: The surface is pallid, the face appears tranquil, the eyes and mouth being partly open. The skin often has the appearance known as gooseskin. and, if the body has lain upwards of twelve hours in the water, that of the hands and the feet is sodden by imbibi- tion. The most important external sign is the presence on the mouth and nostrils of a fine froth (possibly blood stained), composed of air, mucus, and the medium in which drowning took place; if the body remains three or four days in water, the froth disappears. Exceptionally, fragments of weeds or other small objects may be found tightly grasped in the hands. On opening the thorax the lungs, gray in color, with reddish staining, are seen to be very voluminous, a condition known as ballooning, partly due to infiltration of the lung tissue with some of the medium in which drowning took place, and partly to true edema. The lung substance is inelastic and pits on pres- sure. On section, fluid and froth resembling that found on the lips exude from the divided air passages. Minute subpleural hemorrhages are not infrequently present, and the pleural cavities may contain fluid. The stomach often contains water or other liquid which was involuntarily swallowed during attempts at respiration. Occasionally some of this fluid is forced by vital action into the intes- tines. With one exception, the remaining appearances are those met with after death from asphyxia. The exception is constituted by the blood, which is not only dark colored and fluid, as is usual after death from asphyxia, but is also diluted by the imbibition of water from the stomach and lungs. In death by strangulation: The blood is of a dark color, 313 MEDICAL RECORD. owing to complete reduction of the hemoglobin. The pro- portion of carbonic acid is increased, and owing to its excess the blood coagulates slowly or imperfectly; hence it remains fluid or forms few and soft coagula. The large veins, the pulmonary artery, and the cavities of the right side of the heart may be distended with dark fluid blood, but this is by no means necessarily the case. The left side is usually empty or nearly so. The lungs may be con- gested, but are often pallid and anemic, though the de- pendent parts usually exhibit appearances of hypostatic en- gorgement. The abdominal viscera, especially the kidneys, are often congested. The appearance of the brain varies ; it may be anemic or more or less congested. Special signs characterize special modes of causation of asphyxia. — (From Quain's Dictionary of Medicine.) 3. The physician should note the body ; and the surround- ings, conditions, and circumstances under which it is found. If the body is in a building, he should observe the position and arrangement of furniture, etc., blood, position of body, arrangement of clothes, position and character of weapons, footprints, and finger marks. The body should be examined for signs of violence (wounds, bruises, blood spots) ; lividities; the presence of rigor mortis, etc. The physician should keep his suspicions to himself, hear all he can, ob- serve all he can, say nothing, and communicate with the coroner or medical examiner. 4. A wound inflicted during life is generally character- ized by hemorrhage, coagulation of the blood, eversion of the edges, and retraction of its sides. It may also be in- ferred that the wound was inflicted during life if any of the following are noticed : The presence of inflammation, swelling, pus, or gangrene on the edges of the wound, or if there is any sign of beginning cicatrization. In burns produced before death: There is usually a blis- ter, with a bright, red base, and containing a serous fluid, which is albuminous; occasionally there will be no blister if there has been excessive shock; also, there will be a red line of demarcation between the injured and the un- injured parts, and this, being a vital process, is only de- veloped during life. In burns produced after death there is no true blister, no red base, and gas only is present in place of the serous fluid. 5. According to Taylor, the term insanity is applied to those states of disordered mind in which a person loses the power of regulating his actions and conduct according to the ordinary rules of society. In all cases of real in- sanity the intellect is more or less affected. Intellectual insanity refers to those forms which are characterized by hallucinations and delusions, but in which the patient knows right from wrong. 314 MEDICAL RECORD Moral insanity refers to that condition in which the moral perceptions are blunted, and the patient cannot judge a question of right and wrong. As a rule, moral insanity is accompanied with some intellectual disturbance. STATE BOARD EXAMINATION QUESTIONS. Minnesota State Medical Examining Board. anatomy and histology. 1. Give the histology of a nerve trunk. 2. Describe the origin, relations and distribution of the fifth pair of cranial nerves. 3. Describe the cardiac valves. Between what points on the surface are they situated? 4. Describe the fourth ventricle. 5. Describe the portal vein. 6. Describe the thoracic duct. 7. Describe the azygos veins. 8. Give names and general description of the flexor muscles of the forearm. 9. Describe the pronator muscles. 10. Describe the supinator muscles. PHYSIOLOGY. 1. Describe the human blood, giving reaction, specific gravity, constituents, etc. 2. Describe the secretion of urine. 3. What is the composition, reaction, and function of the pancreatic juice? 4. Describe the pulmonary circulation and the changes which are produced in the blood by aeration. 5. Describe the secretion of milk, and give the composi- tion of human milk and cow's milk. 6. What are the functions of the skin? 7. Describe the normal heart sounds, give probable rea- sons for same, and tell where best heard? 8. Enumerate the functions of the spinal cord and its special centers. 9. Explain the physiology of visual accommodation to light and distance. 10. Give the physiology of menstruation. Note — Credits will be given for all diagrams used in explaining questions. . MATERIA MEDICA AND TOXICOLOGY. fly Write a model prescription for acute bronchitis, giv- ing reasons for use of each ingredient and explaining each step in the writing of the prescription. 315 MEDICAL RECORD. 2. (a) What are the symptoms of chronic morphine poisoning? (b) What are the symptoms caused by abrupt withdrawal of the drug? (c) What is the treatment of acute poisoning? 3= (a) From what is acetanilid derived? (b) Explain its effects, (c) Give treatment of acute poisoning. 4. (a) From what is hyoscine derived? (b) What is the dose of hydrobromide? Its physiological effects" Some of its therapeutic uses? 5. Give rule for dosage for children according to age. 6. Give in parallel columns, the diagnosis between acute ptomaine poisoning and acute poisoning by arsenic? •74 Explain the action of chloroform as an anesthetic and tell how you would administer it and with what pre- cautions. 8. What are the adult doses of and physiological anti- dotes for Tr. strophanthus, apomorphine (by hypodermic), carbolic acid, and chloral hydrate? 9. Explain the action on the bowels of opium, thymol, and bismuth subnitrate. 10. (a) What is the U. S. Pharmacopoeia? (b) What is the National Formulary? (c) What is a fluid extract? (d) What is a chemical antidote? CHEMISTRY AND URANALYSIS. 1. Define specific gravity; an acid; a base; allotropy ; synthesis. 2. (a) Give law of definite proportions, (b) Give tests for iodine, silver, mercury. 3. Give a test for sewage contamination of drinking water. What do you consider a good drinking water? 4. Give fully the clinical significance of albuminuria. Name the urinary casts and the commonly associated kid- ney lesions. 5. Give a test for indican. What is its clinical signifi- cance ? 6. What is the diazo-reaction of Ehrlich and its signifi- cance ? 7. How do you estimate urea? 8. What is the diagnostic value of tests for organic acids found in stomach contents? Describe a test for lactic acid. 9. What is the normal reaction of cow's milk? Why is it important to determine the reaction before steriliza- tion? 10. Give test for blood. What is the freezing point for blood? BACTERIOLOGY. I. In what diseases have the specific microorganisms been recovered from the blood? 316 MEDICAL RECORD. 2. (a) Give fully the technique of finding the tubercle bacillus in suspected sputum, (b) What is Gram's and Weigert's method of staining? Illustrate its differential value. 3. Describe the preparation of diphtheria antitoxin. How is its action explained? 4. Describe the morphology of the microorganisms causing tetanus, gonorrhea, spinal meningitis, relapsing fever. Give mode of infection. 5. (a) What is the present status of the bacteriology of scarlet fever, rheumatism, and syphilis? (b) Give morphology and cultural properties of the Diplococcus pneumonia. PRACTICE OF MEDICINE. 1. Describe lichen planus. 2. Describe a typical case of acute miliary tuberculosis. 3. Define bronchiectasis? Give symptoms and physical signs. 4. Nephrolithiasis. Give symptoms fully. Differentiate from appendicitis. 5. Describe the usual symptoms in the secondary stage of syphilis. 6. Differentiate in parallel columns, gastric ulcer and gastralgia. 7. Hereditary ataxia (Friedreich's disease) : Describe symptoms and usual course of disease. 8. Differentiate articular rheumatism and arthritis de- formans. 9. Define arteriosclerosis. Give usual causes. With what other diseases is it frequently associated? 10. Hematuria : Give principal causes. How would you determine source of hemorrhage? SURGERY. 1. (a) Give the surgical definition of "tumor." (b) Classify tumors histologically. 2. (a) Define "wound." (b) Give classification. 3. Give in detail, treatment of a punctured wound in- volving the deep palmar arch. 4. State fully how you would treat a blank cartridge wound of the palm of the hand, and give reason for your plan of treatment. 5. Describe step by step the operation of ligature of the ulnar artery at the wrist, giving linear and muscular guides. 6. (a) Define "fracture." (b) Give general classifica- tion of fractures. 7. Pathology, symptoms, and treatment of Pott's frac- ture. 317 MEDICAL RECORD. 8. Tracheotomy: Describe operation and after treat- ment. 9. How would you reach a diagnosis in a case of sus- pected coxitis? 10. Describe fully the treatment of strangulated in- guinal hernia. GYNECOLOGY. 1. Give differential diagnosis between ovarian cyst and extrauterine pregnancy. 2. Describe your method of repairing a lacerated cervix. 3. Describe inversion of the uterus, giving symptoms, diagnosis, and treatment. 4. Describe uterine polypus, give symptoms, diagnosis, and treatment. 5. (a) Give two indications for hysterectomy, (b) Your reasons for chosing vaginal or abdominal route. DISEASES OF CHILDREN. 1. Give etiology, pathology, and diagnosis of rachitis. 2. Give symptoms of pertussis and differentiate it from acute bronchitis. 3. What alterations would you make in modified milk to overcome constipation. 4. Give briefly differential diagnosis between epilepsy, convulsions due to intestinal irritation, and uremic convul- sions. 5. Give symptoms and treatment of dilatation of the stomach. OBSTETRICS. 1. Describe fully your management of a case of face presentation. 2. Describe your management of a case of neglected transverse presentation where version fails. 3. In contracted and deformed pelvis, enumerate the different methods to be considered in delivery of child and state your reasons for each. 4. Describe fully your management of prolapse of cord. 5. Give your treatment of different grades of asphyxia in the new born. 6. Describe symptoms and treatment of ectopic preg- nancy. 7. Describe caput succedaneum and cephalhematoma and give causes of each. 8. Give indications for podalic version. 9. Give your treatment of puerperal septicemia. 10. Give etiology and treatment of mastitis. PATHOLOGY. 1. Give pathology of anemia 2 pernicious anemia, and chlorosis. 318 MEDICAL RECORD. 2. Describe changes in chronic alcoholism. 3. Pathology of carcinoma of liver. 4. Give pathological findings in typhoid fever. 5. Describe pathological changes in nephritis. EYE AND EAR. i. Differentiate glaucoma and iritis. 2. Describe choked disc and in what diseases we may expect to find it. 3. Define myopia, hypermetropia, astigmatism. 4. How would you treat a discharging ear? 5. Describe otitis media. MEDICAL JURISPRUDENCE. i. Describe phenomena and signs of death. 2. How would you distinguish human bood from that of other sources? 3. Describe death by hanging; how would you determine whether penal or suicidal, ante- or post-mortem? 4. What is life insurance and upon what does the pre- mium rate depend? 5. What is the normal duration of pregnancy and what are the most important signs of delivery in the living and in the dead? PREVENTIVE MEDICINE. 1. What quarantine measures are necessary in a case of (a) smallpox^ (b) diphtheria, (c) scarlet fever? 2. Describe in detail how you would manage cases of typhoid for the protection of the community. 3. How are the following diseases transmitted: (a) Diphtheria, (b) yellow fever, (c) typhoid fever? 4. How long would you keep in quarantine a case of (a) scarlet fever, (b) diphtheria, (c) smallpox? 5. Give a simple, practical method of ventilating a dwel- ling in this climate during the winter season. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Minnesota State Medical Examining Board. anatomy and histology. 1. See Cunningham's "Anatomy" (1909), Page 444; or Gray's "Anatomy" (1908), page 819. 2. Fifth pair of cranial nerves. Origin: (1) Super- ficial, from the side of the pons varolii; (2) Deep (sensory root), from the medulla, and upper part of cord; (motor 319 MEDICAL RECORD. root) from floor of fourth ventricle, and side of the aque- duct of Sylvius. Distribution: First ophthalmic branch supplies sensation to conjunctiva and skin of upper eyelid, cornea, skin of forehead and nose, lachrymal glands, mucous membrane of nose. Second, or superior maxillary branch, supplies sensation to skin and conjunctiva of lower lid, nose, cheek, upper lip, upper teeth and alveolar processes, and palate. Third, or inferior maxillary branch, supplies sensation to external auditory meatus, side of head, mucous membrane of mouth, anterior two-thirds of tongue, lower teeth, lower lip, and skin of the lower part of the face. This branch, in addition, supplies motion to the muscles of mastication (masseter, temporal, external pterygoid, internal ptery- goid), also mylohyoid and anterior belly of digastric. Relations: See Cunningham's "Anatomy" (1909), page 678; or Gray's "Anatomy" (1908), page 1046. 3. Relation of , the cardiac valves to the chest wall: "The aortic valves lie behind the third intercostal space, close to the left side of the sternum. The pulmonary valves lie in front of the aortic behind the junction of the third rib, on the left side, with the sternum. The tricus- pid valves lie behind the middle of the sternum, about the level of the fourth costal cartilage. The mitral valves lie behind the third intercostal space, about one inch to the left of the sternum." (Holden.) 4. See Cunningham's "Anatomy" (1909), page 487; or Gray's "Anatomy" (1908), page 878. 5. See Cunningham's "Anatomy" (1909), page 902; or Gray's "Anatomy" (1908), page 769. 6. See Cunningham's "Anatomy" (1909), page 906; or Gray's "Anatomy" (1908), page 775. 7. See Cunningham's "Anatomy" (1909), page 872; or Gray's "Anatomy" (1908), page 752. 8. 9 and 10. See Cunningham's "Anatomy" (1909), pages 352, 335, and index (for muscles required) ; or Gray's "Anatomy" (1908), page 314, and index (for muscles re- quired). PHYSIOLOGY. 1. The physical properties of blood : Fluid, somewhat vis- cid, red, specific gravity from 1055 to 1062, alkaline reaction, saltish taste, characteristic odor, variable temperature (average about 100 degrees F.). The constituents of the blood are plasma and corpuscles. The plasma consists of water and solids (proteids, extract- ives, and inorganic salts). The red corpuscles consist of water and solids (hemoglobin, proteids, fat, and inorganic salts). The white corpuscles consist of water and solids (proteid, leucomiclein, lecithin, histon, etc.). 320 MEDICAL RECORD. The red blood corpuscles are biconcave discs, about 1-3200 of an inch in diameter ; they are nonnucleated, and there are about 4,500,000 or 5,000,000 of them in each cubic millimeter of blood. They are elastic and soft, and their shape is changed by pressure, but is promptly regained on the removal of the pressure. Their color is yellowish. They contain hemoglobin. Their function is to carry oxygen from the lungs to the tissues. The white blood cells are spheroidal masses, varying in size, having no cell wall, and containing one or more nuclei ; there are about 7,000 to 10,000 of them in each cubic millimeter of blood. They differ much in appear- ance, and are divided into (1) small mononuclear leu- cocytes, or lymphocytes, (2) large mononuclear (3) transi- tional, (4) polynuclear, or polymorphonuclear, or neutro- phile, and (5) eosinophile. They are all more or less granular, particularly the last two varieties named. They are probably formed in the spleen, lymphatic glands, and lymphoid tissues. Their fate is uncertain ; it has been as- serted that they are converted into red blood cells ; they play a part in the formation of fibrin ferment; they are sometimes converted into pus cells. Their functions are (1) to serve as a protection to the body from the incur- sions of pathogenic microorganisms ; (2) they take some part in the process of the coagulation of the blood; (3) they aid in the absorption of fats and peptones from the intestine, and (4) they help to maintain the proper proteid content of the blood plasma. There are also platelets, which are very small, colorless, irregular shaped bodies ; they are about one-fourth the diameter of a red corpuscle. Their function is not deter- mined ; it is possible that they take some part in the coagu- lation of the blood. In number they vary from about 200.000 to more than 500,000 in each cubic millimeter of blood. Plasm conveys nutriment to the tissues ; it holds in solu- tion the carbon dioxide and water which it receives from the tissues, and takes them to be eliminated by the lungs, kidneys, and skin ; it also holds in solution urea and other nitrogenous substances that are taken to and excreted by the liver or kidneys. 2. The mechanism of the secretion of urine by the kid- neys is twofold: (1) By filtration, most, if not all, of the fluid is eliminated, and also inorganic salts ; this depends upon blood pressure, and takes place in the glomeruli. (2) By cell activity and selection, in the cells of the convoluted tubules, the urea and principal solids are eliminated. 3. Pancreatic Juice: Composition: Water and solids, the latter consisting of three enzymes (trypsin, amylopsin, 321 MEDICAL RECORD. and steapsin), proteid material, soap, fats, lecithin, and inorganic salts (carbonate of sodium, chloride of sodium, and phosphates of sodium, calcium, and magnesium). The reaction is alkaline, due to sodium carbonate. The functions: (i) It changes proteids into proteoses and peptones, and afterwards decomposes them into leucin and tyrosin; (2) it converts starch into maltose; (3) it emulsifies and saponifies fats, and (4) it causes milk to curdle. 4. For pulmonary circulation, see Cunningham's "Anat- omy" (1909), page 991; or Gray's "Anatomy" (1908), page 1404. The changes produced in the blood by aeration, are: (1) The living up of carbon dioxide; (2) the absorption of oxygen: (3) the color is made more red; (4) the blood is cooled, and (5) it also loses a small amount of watery vapor. 5. Secretion of milk: "The fatty matters in milk are ap- parently formed at the expense of the protoplasm of the epithelial cells. The casein and milk sugar are also formed in the cells. That fat is formed out of the proteid matter of the protoplasm of the cell, and not from the fat taken as food, is proved by the fact that a bitch fed on meat gives out more fat in her milk than has been taken in her food. The secretion of milk is under the influence of the nervous system. There appears to be a nerve-center in the cord, the sensory and motor-secretory fibers being contained in the intercostal nerves. The amount and quality of the milk is influenced both by the mental state and food taken by the mother." — (Ashby.) HUMAN MILK CONTAINS APPROXIMATELY : Proteid, Fats, Sugar, about 1 to 2% about 3 to 4% about 6 to 7% COW'S MILK CONTAINS APPROXIMATELY : Proteid, Fats, Sugar, about 4% about 4% about 4% 6. The functions of the skin are : Protection, sense of touch, excretion, regulation of body temperature, absorp- tion, and respiration. 7. The causes producing the first sound of the heart are not definitely ascertained; the following are supposed to be causatory factors: (1) the vibration and closure of the auriculo-ventricular valves, (2) the muscular sound produced by the contraction of the ventricles, and (3) the cardiac impulse against the chest wall. The second sound is caused by the vibration due to the closure of the semilunar valves. 322 MEDICAL RECORD. The first sound is heard best at the apex; the second sound is heard best at the base. 8. The functions of the spinal cord are: (i) The con- duction of impulses and impressions ; (2) as a series of nerve centers. The special centers in the spinal cord are the centers for (1) cilio spinal center, (2) for sphincter of bladder, (3) for sphincter of rectum, (4) for erection, (5) for con- traction of uterus, (6) for maintaining tonus of muscles. 9. "Mechanism of Accommodation. — The lens is an elastic structure, and when released from the flattening influence of its suspensory ligament tends to assume a spherical shape. During accommodation the ciliary muscle (espe- cially the circular fibers) contracts, drawing forward the choroid and relaxing the suspensory ligament ; this dimin- ishes the tension of the lens capsule and allows the in- herent elasticity of the lens to increase its convexity. The change in curvature affects chiefly the anterior sur- face of the lens. This is Helmholtz's theory and the one usually accepted. Lately Tscherning has advanced a dif- ferent theory; he maintains that the ciliary muscle in- creases the tension of the suspensory ligament during con- traction and that this causes peripheral flattening of the lens with bulging anteriorly at its center. The act of ac- commodation is accompanied by contraction of the pupil, and (in binocular vision) by convergence of the visual lines." (May's Diseases of the Eye.) 10. See Williams' "Obstetrics" (1909), page 81 ; or Hirst's "Obstetrics" (1909), page 57. MATERIA MEDICA AND TOXICOLOGY. 1. IJ. Ammonii carbonatis, 5j. Spiritus chloroformi, 5j. Syrupi pruni virginianse, 5j. Misturse glycyrrhizae composite, q.s. ad. Jviij. Misce. Signa : One teaspoonful every three hours. The ammonium carbonate is a respiratory stimulant and a stimulating expectorant. The chloroform disguises the taste of the ammonium. The prunus virginiana is a seda- tive and expectorant. The glycyrrhiza is an expectorant. 2. (a) Symptoms of chronic morphine poisoning: Great mental depression, irresolution, loss of self-control, great longing for the drug, nausea, insomnia, anxiety, melancholia, feeble pulse, diarrhea, muscular cramps, and "lying." (b) Symptoms caused by abrupt withdrawal of the drug : Diarrhea, vomiting, insomnia. (c) Treatment of acute morphine poisoning: "Wash out the stomach with a dilute solution of potassium permarh 323 MEDICAL RECORD. ganate, leaving about 500 c.c. in the stomach; and main- tain the respiration. In the first or second stage the 'ambulatory treatment' should be adopted to prevent, if possible, the establishment of the third stage. If this stage develop, the main reliance is to be placed in main- taming the respiration by artificial methods, until the poison has been eliminated. Strong coffee, or caffein, by the mouth or rectum, are of benefit. The same cannot be said of atropin. The urine should be drawn by the catheter." (Witthaus' Essentials of Chemistry.) 3. (a) Acetanilid is derived from aniline, by the action on it of glacial acetic acid. (b) The continuous use of acetanilid may give rise to decrease in the number of red blood cells ; the face is livid and covered with perspiration, the respirations become slow and shallow, the pulse soft, compressible, and gradu- ally weaker. {c) Treatment: Stop further administration of the drug, then support the patient by stimulants, warmth and strych- nine. 4. (a) Hyoscine is derived from Hyoscyamus. (b) The dose of the hydrobromide is gr. 1/128. Its physiological effects: it quiets the cerebrum and pro- duces sleep; it may also produce delirium; it also causes loss of reflex action. It is used as a hypnotic, in acute mania, insomnia, hys- teria; also in morphine and alcohol habit; it is also used as a sedative mydriatic in plastic iritis. x 5. Let x == the age of a patient ; then = the f rac- x + 12 tion of the adult dose which the patient should receive. Thus, a patient of four years old should receive 4 4 1 =z — = — of an adult dose. 4 + 12 16 4 6. The following table, from Gould and Pyle's Cyclo- pedia of Medicine and Surgery, gives the diagnosis be- tween Ptomaine Poisoning, and Poisoning by Arsenic: PTOMAINE POISONING. 1. Onset often from 2 to 24 hours. 2. Results from eating animal (nitrogenous) food. 3. Nervous symptoms marked (twitching of facial muscles, tingling sensations, dilated pupils, convulsio ns). ARSENIC POISONING. i. Onset within half an hour. 2. History negative. 3. Nervous phenomena, as seen in autointoxication, ab- sent. 324 MEDICAL RECORD PTOMAINE POISONING. 4. Early dyspnea, cyano- sis. 5. Temperature often sub- normal. 6. Dryness of mouth and fauces, often bitter taste. 7. Vomitus contains mu- cus, contents of stomach, or bile. 8. Generally watery diar- rhea, sometimes constipa- tion. 9. Various cutaneous erup- tions (scarlatinal eruptions, urticaria). ARSENIC POISONING. 4. Dyspnea comes on late in mineral poisoning. 5. Temperature often ele- vated a degree or two. 6. Metallic taste in mouth. 7. Vomitus variable, often tinged with blood, and con- taining trace of poison. 8. Feces may contain blood and trace of poison. 9. Cutaneous eruptions ab- sent. 7. Chloroform acts as an anesthetic by paralyzing and suspending the functions of the higher centers in the cere- brum, while at the same time allowing the lower centers in the medulla to carry on the functions of circulation and respiration. For administration, see Rose and Carless' "Surgery" (1908), pages 1321 and 1324; or Da Costa's (1908), page 1030. Tr. strophanthus Apomorphine (by hypodermic) Carbolic acid Chloral hydrate ADULT DOSE. I PHYSIOLOGICAL ANTIDOTE. TT£. V11J gr. i/lO gr. j gr. xv Nitroglycerin ; amyl nitrite None Magnesium or sodium sulphate Strychnine. 9. Opium depresses the motor activity of the intestines, prevents peristalsis, and causes constipation. Thymol is an intestinal antiseptic and disinfectant. Bismuth sulnitrate has but little effect on the bowels; it is mildly protective, and astringent. io ; (a) The U. S. Pharmacopoeia is an official list of medicinal substances, with definitions, descriptions, or for- mulae for their preparation ; it is recognized by the med- ical profession of the United States, but has no legal authority. (b) The National Formulary is a collection of prepara- tions not contained in the U. S. Pharmacopoeia. (c) Fluid extracts are liquid alcoholic preparations of 32: MEDICAL RECORD. nearly uniform strength ; each cubic centimeter of the fluid extract represents one gram of the drug. (d) A chemical antidote is one that changes the chem- ical character of the poison, and so renders it inert. CHEMISTRY AND URANALYSIS, 1. Specific gravity is the weight of a substance as com- pared with the weight of a like volume of a given sub- stance, taken as a standard, under similar conditions of temperature and pressure. An acid is a compound of an electronegative element or radical with hydrogen, part or all of which hydrogen it can part with in exchange for an electropositive element, without the formation of a base. A base is a ternary compound capable of entering into double decomposition with an acid to produce a salt and water. Allotropy is the property possessed by some elements (such as oxygen, sulphur, phosphorus) of appearing under different forms in which their general chemical characters are unchanged, but their physical properties vary. Synthesis is the formation of compounds from elements or from simpler compounds. 2. (a) The law of definite proportions: The same com- pound always contains the same elements and in the same proportions. (b) Test for iodine: Add starch paste; in the presence of iodine it becomes blue. Test for silver : Add hydrochloric acid ; in the presence of silver a white precipitate is formed which is insoluble in nitric acid, but soluble in ammonium hydroxide. Test for mercury : The Reinsch test is as follows : To the suspected fluid add a little pure HC1 ; suspend in the fluid a small strip of bright copper foil, and boil. If a deposit forms on the copper, remove the copper, wash it with pure water, dry on filter paper, but be careful not to rub off the deposit. Coil up the copper, and put it into a clean dry, glass tube, open at both ends, and apply heat at the part where the copper is. If mercury is present there will appear in the cold part of the tube a mirror, which will be found on microscopical examination to con- sist of metallic globules of mercury. 3. Sewage contamination of drinking water can be de- tected by the presence of the colon bacillus ; also by Wank- lyn's or Frankland's method of analysis. A good drinking water is one that is cool, limpid, odorless, neither sweet nor salty, has no sediment, is transparent; it should have not more than 30 or 40 grains of total solids to the gallon ; chlorine should be less than 4 parts in 100,000; nitrites, none ; nitrates, none or a mere trace. 326 MEDICAL RECORD. 4. (a) Albumin is found in the urine: "(1) In fevers, as typhoid and pneumonia. (2) In valvular heart lesions, degeneration of the heart muscles, diseases of the coronary arteries, impeded pulmonary circulation, in pregnancy by pressure upon the renal veins, in intestinal catarrh, and in Asiatic cholera. (3) In purpura, scurvy, leukemia, per- nicious anemia, jaundice, diabetes, and syphilis. (4) After taking lead, mercury, iodine, phosphorus, arsenic, anti- mony, chloroform, cantharides, oxalic, carbolic, salicylic or the mineral acids, turpentine and nitrates. (5) In large amounts in acute nephritis and chronic parenchymatous nephritis ; in small amounts in chronic interstitial nephritis and amyloid kidney/' (Witthaus' Essentials of Chem- istry.) (b) "Casts in the urine occur in nephritis, and different varieties are found in the different forms of that disease. Hyaline casts occur in all forms of nephritis, in congestion of the kidneys, in jaundice, and even in health. Waxy casts occur especially in chronic parenchymatous nephritis. Epithelial casts occur especially in acute parenchymatous nephritis. Granular casts are especially common in chronic nephritis, but they may occur in acute nephritis. Fatty casts occur chiefly in chronic parenchymatous nephritis. Blood casts occur in acute and chronic hemorrhagic nephritis. Pus and bacterial casts are occasionally met with in suppurative nephritis." (From Stevens' Practice of Medicine.) 5. Test for indican in the urine : The urine is mixed with one-fifth its volume of 20 per cent, solution of lead acetate and filtered. The filtrate is mixed with an equal volume of fuming hydrochloric acid containing 3:1000 of ferric chlorid, a few drops of chloroform are added, and the mixture strongly shaken one to two minutes. With normal urine the chloroform remains colorless, or almost so ; but if an excess of indoxyl compounds be present the chloroform is colored blue, and the depth of the color is a rough indication of the degree of the excess. I ndic anuria is found in hypochlorhydria ; in hyperchlor- hydria of gastric ulcer ; in conditions in which there is diminished peristalsis of the small intestines, as in ileus and peritonitis, not in simple constipation ; also in condi- tions in which putrefactive changes occur in the body else- where than in the intestine, as in empyema, putrid bron- chitis, gangrene of the lungs, etc. (From Witthaus , Essen- tials of Chemistry.) 6. For the diazo reaction of Ehrlich, two solutions are required: (1) A saturated solution of sulphanilic acid in a mixture of 50 c.c. of hydrochloric acid and 950 c.c. of water; and (2) a 0.5 per cent, solution of sodium nitrite. To. make the test, 1 c.c. of (2) is added to 40 c.c. of (1) 327 MEDICAL RECORD. and the mixture thoroughly shaken. Equal quantities of this mixture and the urine to be tested are shaken together in a test tube, and i c.c. of ammonia is then floated upon the surface, when, in an affirmative result, a red band is formed at the junction of the fluids. Its diagnostic value is uncertain. Von Jaksch "disclaims for this test any clinical importance whatever." Others have claimed that the reaction is pathognomonic of typhoid ; but it has been found in other diseases besides typhoid — namely, phthisis, pneumonia, measles, scarlet fever, small- pox, and malaria. 7. A comparatively easy test for Urea is that of Fowler, based upon the loss of the specific gravity of the urine after the decomposition of the urea by hypochlorite. "To apply this method the specific gravity of the urine is care- fully determined, as well as that of the liquor sodse chlorinatae (Squibb's). One volume of the urine is then mixed with exactly seven volumes of the liquor sodse chlorinatae, and, after the first violence of the reaction has subsided, the mixture is shaken from time to time during an hour, when the decomposition is complete ; the specific gravity of the mixture is then determined. As the reaction begins instantaneously when the urine and reagent are mixed, the specific gravity of the mixture must be calcu- lated by adding together once the specific gravity of the urine and seven times the specific gravity of the liquor sodse chlorinatae, and dividing the sum by eight. From the quotient so obtained the specific gravity of the mix- ture after decomposition is subtracted; every degree of loss in specific gravity indicates 0.7791 gram of urea in 100 c.c. of urine. The specific gravity determinations must all be made at the same temperature ; and that of the mixture only when the evolution of gas has ceased en- tirely/' (Witthaus' Manual of Chemistry.) 8. The presence in the stomach contents, after a test meal, of considerable quantities of organic acids is sup- posed to be pathological. Lactic acid, particularly, is sup- posed to be diagnostic of cancer of the stomach. Organic acids, as a rule, denote pyloric stenosis, gastric dilatation, or deficient motor power of the stomach. "The presence of lactic acid is detected by Uffelmann's reagent, which consists of a solution of Fe 2 Cl 6 and phenol, diluted to an amethyst-blue color, which is changed to yellow by lactic acid. In order to avoid error by the action of other substances which have a like action upon the reagent, 10 c.c. of the filtered gastric contents are agitated with ether, and the ethereal extract separated and agitated with the reagent; or it may be evaporated, the residue dissolved in water, and the solution added to the reagent." (Witthaus' Manual of Chemistry.) 328 MEDICAL RECORD. 9. The normal reaction of cow's milk is acid or neutral. If acid, lime water, or sodium bicarbonate must be added after sterilization. 10. Test for blood : Let some of the stained material soak thoroughly in a very small quantity of saturated solu- tion of sodium chloride. Put a few drops of the fluid on a slide, cover with a cover-glass, let evaporation occur, allow a drop of glacial acetic acid to enter from the side, and gently warm. On cooling, haemin crystals form, and can be seen under the microscope. The freezing point for blood is given as 0.56 . BACTERIOLOGY. 1. The specific microorganisms have been recovered from the blood, in the following diseases : Typhoid, relapsing fever, cerebrospinal meningitis, malaria, diphtheria, ery- sipelas, influenza, tuberculosis, cholera, anthrax, pneu- monia, syphilis (?), leprosy, bubonic plague, gonorrhea, tetanus. 2. (a) To demonstrate the existence of tubercle bacilli in the sputum : The sputum must be recent, free from par- ticles of food or other foreign matter ; select a cheesy- looking nodule and smear it on a slide, making the smear as thin as possible. Then cover it with some carbol- fuchsin, and let it steam over a small flame for about two minutes, care being taken that it does not boil. Wash it thoroughly in water and then decolorize by immersing it in a solution of any dilute mineral acid for about a min- ute. Then make a contrast stain with solution of Loeffler's methylene blue for about a minute ; wash it again and examine with oil immersion lens. The tubercle bacilli will appear as thin red rods, while all other bacteria will ap- pear blue. (b) Gram's method: "The section is stained in anilin- water gentian-violet (Koch-Ehrlich) diluted with one- third its volume of water. The section remains in this for about ten minutes at the temperature of the incubator. From this it is taken out and washed alternately in Gram's iodine solution and alcohol until all the naked-eye color has been extracted. It is then put into a watery solution of eosin or Bismarck-brown for one minute, again washed in alcohol a few seconds, and then put for one-quarter minute in absolute alcohol. After this it is transferred to xylol for one-half minute, then lifted to a slide, mounted in Canada balsam, and examined." Weigerfs modification: "Stain sections in the Koch-Ehr- lich anilin-water gentian-violet solution for five or ten minutes; wash them afterward in water or physiological salt solution. Transfer to slide and remove excess of fluid with blotting-paper. Treat with the iodine solution of 329 MEDICAL RECORD. Gram for three minutes. Take up the excess of solution with blotting-paper. Cover the section with anilin oil, wash out the oil with xylol, and mount in xylol balsam. The anilin oil in this case acts as a decolorizing agent, and should be removed carefully, otherwise the specimen will not keep." — (Archinard.) Gram Positive: Staphylococcus pyogenes aureus and al- bus ; streptococcus pyogenes ; micrococcus tetragenus ; pneumococcus ; Klebs-Loeffler bacillus; tubercle bacillus; tetanus bacillus ; anthrax bacillus. Gram Negative: Gonococcus; diplococcus mtracellularis meningitidis; typhoid bacillus; colon bacillus; influenza bacillus; glanders bacillus. 3. Diphtheria antitoxin is obtained from the horse, the animal having been rendered artificially immune by re- peated injections extending over a period of several months of gradually increasing quantities of the strongest diphtheria toxin. As the bacilli themselves are not in- jected, the horse does not become infected with diphtheria, but he gradually acquires a tolerance for the toxins of the disease and develops in his blood a substance (antitoxin) which has the power to neutralize those toxins. At the proper time, when it is thought that his blood has acquired the requisite degree of potency, the animal is bled, and the serum — the part of the blood containing the antitoxin — is carefully separated from the clot, filtered, and standard- ized. The last procedure is accomplished by determining the quantity of antitoxin serum required to offset the effects of the minimum quantity of toxin necessary to kill a guinea-pig in a definite time. The strength of the anti- toxin is measured in units, a unit containing the amount of antitoxin required to save the life of a guinea-pig which has been injected with 100 faial doses of toxin." — (Stevens' Materia Me die a.) How antitoxin produces immunity and effects cure is not known, but theories deduced from observed facts are as follows : "As the various pathogenic bacteria produce the causative toxins of their respective diseases, so the organic cells of the body, reacting under the stimulus of the poisons thus introduced, immediately proceed to elaborate defensive bodies, which if produced in sufficient quantity will neutral- ize the effects of the toxins. Residual anti-bodies remain- ing in the blood after recovery render the animal immune for a time against the disease. The immunizing and cura- tive effects obtained by the injection of the. blood serum of an immunized animal into the circulation of another ani- mal are due either to direct chemical neutralization of the toxins themselves by the antibodies so introduced (Beh- ring, Kitasato), or to a particular influence exerted by the antibodies upon the living cells of the organism which 330 MEDICAL RECORD. being affected in two opposite directions, remain neutral to the disease (Buchner). Some authorities hold that these results are due to the conjoint action of leucytic and chem- ical forces. Ehrlich's sidechain theory assumes that every toxin contains toxophore molecules having direct toxic ac- tion, and haptophore molecules which combine the toxo- phores with a similar combining group of molecules in the tissue cell of the attacked organism. The tissue cell mole- cules being destroyed by the toxophores, a rapid and pro- fuse regeneration of similar molecules occurs in side chains and these molecules overgrowing are carried into the circu- lation, becoming the antitoxin, which acts by combining with the haptophores of newly arrived toxin, using up their combining power before they can reach the tissue cells." — (Potter's Materia Medica, etc.) 4. See French's "Practice of Medicine" (1907), pages 406, 214, 1206, 139, and 128; or Osier's "Practice of Medi- cine" (1909), pages 259, 159, and no. The gonococcus is a diplococcus, and is recognized by staining with the ordinary aniline dyes, being found inside the pus cells ; it is Gram negative, and can be cultivated on human blood serum, but will not grow on the ordinary culture media. 5. (a^> ^ee French's "Practice of Medicine" (1907), pages 315 and 222; or Osier's "Practice of Medicine" (1909), pages 130, 221, and 266. (b) Diplococcus pneumonic? is a small oval coccus, alone or in pairs, sometimes in chains like streptococci ; generally oval and double as a diplococcus, and surrounded by a cap- sule. In solid media it grows as above; in liquid media the cells are more round, and the chains are longer. PRACTICE OF MEDICINE. 1. Lichen planus "is a chronic inflammatory disease of the skin characterized by small, flat, angular, umbilicated. glazed, reddish papules, accompanied by intense itching. The eruption may appear suddenly or gradually and usual- ly appears on the extremities. The lesions vary in size from a pinhead to a pea and tend to occur in patches which often assume a linear form. The papules are flat, angular, glazed, slightly umbilicated, and of a reddish or violaceous color. As -the affection progresses scales form on the le- sions. Itching js marked. After the eruption subsides, the sites of the lesions remain pigmented for an indefinite pe- riod."— (Hughes' Practice of Medicine.) 2. See French's "Practice of Medicine" (1907), page 344; or usler's "Practice of Medicine" (1909), page 298. 3. See French's "Practice of Medicine" (1907), page 656: or Osiers' "Practice of Medicine" (1909), page 606. 331 MEDICAL RECORD. 4. See French's "Practice of Medicine" (1907), pages 910 and 796; or Osier's "Practice of Medicine" (1909), pages 709 and 518. 5. See French's "Practice of Medicine" (1907), page 421; or Osier's "Practice of Medicine" (1909), page 267. 6. See French's "Practice of Medicine" (1907), page 769; or Osier's "Practice of Medicine" (1909), pages 494 and 474. 7. See French's "Practice of Medicine" (1907), page 1057; or Osier's "Practice of Medicine" (1909), page 921. 8. See French's "Practice of Medicine" (1907), page 919; or Osier's "Practice of Medicine" (1909), page 393. 9. Arteriosclerosis is a condition in which the walls of an artery, especially the intima, become hard, dry, and thickened. Usual causes : Syphilis, alcoholism, gout, Bright' s dis- ease, overeating, and excessive muscular exertion. It is most liable to occur in old age. It is frequently associated with : Chronic interstitial nephritis, chronic myocarditis, paralysis, and gangrene. 10. The principal causes of hematuria are : ( 1 ) Condi- tions in which the blood is affected, as in the infectious diseases, in scurvy, pernicious anemia, and purpura; (2) traumatism or inflammations in any part of the urinary tract; (3) congestion of the kidneys secondary to dis- ease of the lungs, heart, or liver. In renal hematuria the blood and urine are intimately mixed, tube casts are apt to be present, and there may be renal colic or pain in the lumbar region. In vesical hema- turia the blood and urine are not so well mixed, and pure blood is apt to be passed at the end of urination. In urethral hematuria the urine first passed is bloody. SURGERY. 1. See Rose and Carless' "Surgery" (1908), pages 183 and 188; or Da Costa's "Surgery" (1908), pages 296 and 302. 2. A wound is a solution of surface continuity, caused by sudden mechanical force. Wounds are classified as : I. Contused and open wounds. 11. Open wounds may be : Incised, lacerated, contused, punctured, gunshot, or poisoned; also penetrating and per- forating. III. Aseptic and septic. 3. See Rose and Carless' "Surgery" (1908), pages 238 and 295; or Da Costa's "Surgery" (1908), pages 252, 374 and 386. 4. After a blank-cartridge wound of the palm of the hand, the patient should be anesthetised, hemorrhage 332 MEDICAL RECORD. checked, dead tissue and any foreign matter should be removed, the wound thoroughly disinfected and drained, ind it might be well to administer at once a prophylactic dose of antitetanic serum. 5. See Rose and Carless' "Surgery" (1908), page 336; or Da Costa's ''Surgery" (1908), page 406. 6. A fracture is the sudden solution of the continuity of a bone or cartilage. Fractures are variously classified: (a) Simple, compound, and complicated. (b) Complete (transverse, oblique, spiral, longitudinal) and incomplete (fissured, greenstick). (c) Single and multiple. (d) Comminuted, impacted, etc. (e) Intra- and extraarticular; intra- and extracapsular. 7. See Rose and Carless' "Surgery" (1908), page 558; or Da Costa's "Surgery" (1908), page 541. 8. See Rose and Carless' "Surgery" (1908), pages 914 and 919; or Da Costa's "Surgery" (1908), page 769. 9. See Rose and Carless' "Surgery" (1908), page 684; or Da Costa's "Surgery" (1908), page 554. 10. See Rose and Carless' "Surgery" (1908), page 1103; or Da Costa's "Surgery" (1908), page 995. GYNECOLOGY. 1. In extrauterine pregnancy, see below — Obstetrics, Question 6. In the ovarian cyst : The history must be taken very carefully, and there will be found absence of the chief signs of pregnancy; there may be the characteristic facies; and the tumor is soft and fluctuating. 2. See Williams' "Obstetrics" (1909), page 831; or Hirst's "Obstetrics" (1909), page 898. 3. See Hirst's "Obstetrics" (1909), page 614. 4. A uterine polypus is a tumor attached to the internal wall of the uterus by a small pedicle. Symptoms: In- creased hemorrhage at first at the menstrual periods; later the bleeding is continuous. If the polypus has been forced through the internal os there will be painful uterine con- tractions. Sterility, endometritis, and later anemia may re- sult from loss of blood. Diagnosis: Examination with the finger will detect the pyriform tumor protruding through the os or extending into the vagina. If attached low down, the linger passed around the cervix will soon feel the point of attachment. Uterine polypus may be confounded with inversion of the uterus. But in the latter the fundus of the uterus is not in its proper place. Treatment: When the polypus is attached inside the uter- ine cavity high up, the cervix should be dilated; the tu- mor may be grasped in a pair of forceps and the pedicle 333 MEDICAL RECORD. twisted off, or the growth may be removed by galvanocau- tery or wire ecraseur. If attached low down, a V-shaped incision can be made at the base of the pedicle in the mu- cous membrane and the tumor removed. The uterus may then be packed with iodoform gauze. Multiple polypi may be removed with a sharp curet. All these operations should be done under the strictest asepsis. Endometritis accom- panying the condition should be treated as in other cases. — (From Well's Compend. on Gynecology.) 5. (a) Two indications for hysterectomy. Carcinoma and fibroids. (b) As to preference between the vaginal and abdominal routes, the following is taken from Garrigues' Gynecology : "If the vaginal route is available, it should be preferred, because it entails much less shock, requires a simple after- treatment, does not leave any visible cicatrix, predisposes less to hernia, and allows the patient to resume work in shorter time. On the other hand, the vaginal route is more difficult on account of the limited space. Hemorrhage is more troublesome to check, adhesions are harder to sepa- rate, and the bladder and intestine more exposed to injury and less accessible for repair. The pelvic cavity cannot be seen so well, and the abdominal not at all. If tissue is left to mortify, it emits an offensive odor." DISEASES OF CHILDREN. i. See French's "Practice of Medicine" (1907), page 932; or Osier's "Practice of Medicine" (1909), page 426. 2. See French's "Practice of Medicine" (1907), pages 202, 204, and 649; or Osier's "Practice of Medicine" (1909), pages 149 and 602. 3. To overcome constipation, the fats (or both fats and proteids) should be increased. 4. See French's "Practice of Medicine" (1907), pages 1 124 and 889; or Osier's "Practice of Medicine" (1909), pages 1057, 1063, and 685. 5. See French's "Practice of Medicine" (1907), page 742; or Osier's "Practice of Medicine" (1909), page 468. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), page 280; or Hirst's "Obstetrics" (19^9), page 414. 2. See Williams' "Obstetrics" (1909), page 803; or Hirst's "Obstetrics" (1909), page 433. 3. In contracted and deformed pelvis, the different methods to be considered in delivery of the child are : (1) Induction of premature labor; (2) Forceps; (3) Ver- sion; (4) Craniotomy; (5) Cesarean section, or one of its modifications ; (6) Symphyseotomy. So many things have to be taken into consideration that 334 MEDICAL RECORD. it is quite impossible to lay down any hard and fast rules to govern every case. The following table (from King) is a safe guide : WHEN CONJUGATE DIAMETER OF BRIM MEASURES : Between 4 and sy 2 inches. . . Between y/ 2 and 2^4 inches. Between 2yi and 2 inches. . . At 2 inches or less THE MODE OF DELIVERY AT TERM IS: By Forceps. f By Forceps, Version. J Symphyseotomy. ] Cesarean section, or I Craniotomy, pro re nata. f Cesarean section, if child alive. [ Craniotomy, if child dead. ' Cesarean section always. Craniotomy excluded, whether child dead or alive. 4. Treatment of prolapsed funis consists in: (1) Not rupturing the membranes prematurely, unless there is some positive indication; (2) postural treatment, in which the woman is placed on her back or on the opposite side to that on which the cord lies, with hips and pelvis elevated, or the knee-chest position may be adopted; (3) reposition of the cord, either manually, or with some form of re- positor; (4) speedy delivery, by forceps or podalic version. 5. See Williams' "Obstetrics" (1909), page 846; or Hirst's "Obstetrics" (1009), page 939. 6. Diagnosis: "When extrauterine pregnancy exists there are: (1) The general or reflex symptoms of preg- nancy; they have often come on after an uncertain period of sterility; nausea and vomiting appear aggravated. (2) Then comes a disordered menstruation, especially metrorrhagia, accompanied with gushes of blood, and with pelvic pain coincident with the above symptoms of preg- nancy ; pains are often /ery severe, with marked tenderness within the pelvis ; such symptoms are highly suggestive. (3) There is the presence of a pelvic tumor characterized as a tense cyst, sensitive to the touch, actively pulsating; this tumor has a steady and progressive growth. In the first two months it has the size of a pigeon's egg; in the third month it has the s.'.re of a hen's egg; in the fourth month it has the size of two fists. (4) The os uteri is patulous ; the uterus is displaced, but is slightly enlarged and empty. (5) Symptoms No. 2 may be absent until the end of the third month, when suddenly they become severe, with spasmodic pains, followed by the general symptoms of collapse. (6) Expulsion of the decidua, in part or 335 MEDICAL RECORD. whole. Nos. i and 2 are presumptive signs; Nos. 3 and 4 are probable signs; Nos. 5 and 6 are positive signs." (American Text-Book of Obstetrics.) Treatment consists in removal of the product of concep- tion, by a laparotomy, as soon as the diagnosis is made. 7. See Hirst's "Obstetrics" (1909), page 935. The cause of the former is pressure. 8. The indications for Podalic Version are: (1) In transverse presentations; (2) in placenta prsevia; (3) in malpresentations of the head; (4) in simple flattened pelvis, and in minor degrees of pelvic contraction; (5) in pro- lapsed funis; (6) in sudden death of the mother; and (7) in any case where speedy delivery is imperative. 9. See Williams' "Obstetrics" (1Q09), page 883; or Hirst's "Obstetrics" (1909), pages 7^ and 737. 10. See Williams' "Obstetrics" (1909), page 913; or Hirst's "Obstetrics" (1909), page 708. PATHOLOGY. x'. In secondary anemia, the blood would show: (1) A diminution in the number of red corpuscles ; (2) a diminu- tion in the amount of hemoglobin, perhaps greater than that of the red corpuscles; (3) poikilocytosis, and varia- tions in the size of the red corpuscles ; (4) the presence of a few nucleated red corpuscles; (5) a moderate leuco- cytosis. In pernicious anemia the blood would show: (1) A diminution in the number of red corpuscles ; (2) a relative increase in the amount of hemoglobin; (3) poikilocytosis; (4) the presence of nucleated red cells; (5) variation in the size of the red cells; (6) the leucocytes may be diminished. The skin is usually discolored (yellowish) ; fatty degen- eration of the heart is common ; the liver may be fatty. In chlorosis, the blood shows: (1) A great diminution in the amount of hemoglobin; (2) a slight diminution in the number of red corpuscles; (3) poikilocytosis; (4) oc- casionally a few nucleated red corpuscles; (5) a very slight leucocytosis. The skin is generally yellowish-green, and the blood and conjunctiva pale. 2. See French's "Practice of Medicine" (1907), page 955; or Osier's "Practice of Medicine" (1909), page 370. 3. See French's "Practice of Medicine" (1907), page 839; or Osier's "Practice of Medicine" (1909), page 567. 4. See French's "Practice of Medicine" (1907), page 70; or Osier's "Practice of Medicine" (1999), page 65. 5. See French's "Practice of Medicine" (1907), pages 892, 898, and 902; or Osier's "Practice of Medicine" (1909), pages 687, 692, and 695. 33& MEDICAL RECORD I. EYE AND EAR. GLAUCOMA. Age Tension Congestion Cornea Anterior chamber. Pupil Pain Vision Treatment , Over fortv. Plus. General, especially scleral. Cloudy and steamy surface. Shallow. Dilated, oval. Severe, continu- ous. Much reduced. Eserine, pilocarpine iridectomy. IRITIS. Any. Normal. General, especially circumcorneal. Cloudy. Unchanged. Contracted, syn- echias Especially at night. Somewhat re- duced. Atropine. (From Ailing and Griffin's Diseases of the Eye and Ear.) 2. Choked disc is a condition in which the optic papilla is swollen, congested, and inflamed ; it is due to increased intracranial pressure. It occurs in brain tumors, tuberculous meningitis, abscess of the brain, syphilis, nephritis, rheumatism, toxic agents (as lead or alcohol), infectious diseases, and anemia. V 3. Myopia is a condition in which the anteroposterior axis of the eye is abnormally long, and parallel rays are focused in front of the retina. ^ Hypermetropic! is a condition in which the anteropos- terior axis of the eye is abnormally short, and parallel rays are focused behind the retina. Astigmatism is a condition in which owing to a greater curvature of the eye in one meridian than in others, the refractive power of the eye varies. 4. Treatment of a discharging ear: Cleanliness and drainage are primary essentials. The discharge may be removed by sterile cotton, and the use of a warm mild antiseptic lotion. A solution of carbolic acid 1 140 may be dropped in and allowed to remain in the ear for a few minutes. Alcohol may be used when granulations appear. Treatment must only be undertaken once or twice a day, at the first ; and the intervals gradually lengthened as the discharge becomes less. This must be persevered in for a long time. Paracentesis may be necessary, and later on, in complicated cases, the ossicles may have to be removed. 5. Otitis media. Acute catarrhal otitis media is fre- quently caused by acute coryza and the infectious fevers. There is a painless obstructed sensation in one or both 337 MEDICAL RECORD. ears, impairment of hearing, and tinnitus. The intiamma- tion causes closure of the Eustachian tube. Inflation and aspiration of the middle ear and syringing and douching the nares and nasopharynx must be avoided. A moderate spray of Dobell's solution may be used. If pain is present, dry heat, in the form of hot-water bottle, hot stone wrapped in flannel, etc., may be applied. A few drops (ioo), warmed, of carbolic acid solution (i 40), or- one of forma- lin (1:2000), may be instilled into the ear. "Acute purulent otitis media: Acute catarrhal otitis media, instead of undergoing resolution, may pass into acute purulent otitis media (especially in exanthemas) from the passage of pathogenic germs from the naso- pharynx into the middle ear. The pain will become more intense, the hearing dull; tinnitus will become louder and more distressing, and fever usually sets in. Dry heat al- lays the pain. Warmed water or warmed carbolic acid solution (1:40) may be used. Inflations, aspirations, etc., should be avoided. If the nares are filled with tough secre- tions, a spray of Dobell's solution may be used. If the pain continues over six hours in a child or over twelve hours in an adult without spontaneous perforation of the tympanic membrane, paracentesis of that structure should be performed. The concha and meatus should be smeared with petrolatum to avoid chapping, and the secretions should be gently mopped off as they appear. Under this treatment the ear usually returns to normal in two to three weeks." — (Gould and Pyle's Pocket Cyclopedia of Medicine and Surgery.) MEDICAL JURISPRUDENCE. i. Phenomena and signs of death, are : The complete and permanent cessation of circulation and respiration, rigor mortis, loss of body heat, pallor of the body, putre- faction. 2. It is, probably not possible to distinguish absolutely human blood from that of other mammals. By careful measurements of the red corpuscles under the high powers of modern microscopes, human blood can be readily dis- tinguished from that of some animals; but in other cases, such as the differential diagnosis between the blood of a man and that of a dog, there is no absolute certainty. 3. A sure sign of hanging antemortem is the flow of saliva from the mouth, down the chin, and on to the chest. This could not occur in a case of hanging postmortem, as the secretion of saliva is a vital process. 4. Life insurance is a contract whereby the company insuring, in consideration of a certain premium payable as arranged, agrees to pay a certain amount at the death of the assured to his heirs or other designated person, or to the insured himself if living at a certain date. 338 MEDICAL RECORD. The premium rate depends on: The age, physical con- dition, family history, occupation, residence, personal hab- its, health, etc., of the applicant. 5. For normal duration of pregnancy: See Williams' "Ob- stetrics" (1909), page 193; or Hirst's "Obstetrics" (1909).. page 210. Signs of recent delivery. — In the living: Woman is more or less weak, and incapable of exertion; pallor; soft ab- domen with relaxed skin, and linese albicantes : breasts, full, tumid, and secreting milk; presence of colostrum corpuscles in the milk ; secondary areola ; external genitals relaxed and tumefied; os uteri swollen and dilated; fundus hard and globular; lochial discharge; absence of four- chette; lacerated cervix. In the dead: Uterus enlarged, thick and soft; uterus contains blood, clots, and debris of decidua ; tubes and ovaries congested. PREVENTIVE MEDICINE. 1. See French's "Practice of Medicine" (1907), pages 309, 194, and 324; or Osier's "Practice of Medicine" (1909), pages 112, 207, and 138. 2. Typhoid fever is preventable. When the municipal authorities do not consider it their duty to supply pure water, each household should boil all water that is to be used for drinking or for washing dishes, etc. ; milk should be .boiled also; and no ice should be put in water or other drink or food; flies should be kept out of the house as far as possible, by means of screens or otherwise; all dis- charges from the sick person must be disinfected; all utensils, dishes, etc., used by the patient must be thor- oughly cleansed, and boiled every day; soiled linen must be soaked in a disinfectant solution before being washed; after each attendance on a patient, physicians, nurses, and others should wash their hands in a disinfectant ; thorough sterilization of all bedding, etc., must be performed after the disease is over. 3. Diphtheria is transmitted by contact with those al- ready infected, by fomites, by careless disposal of secre- tions, by coughing or sneezing whereby the bacilli are car- ried through the air to the nose or mouth of others. Yellozv fever is transmitted through the bite of an in- fected mosquito (Stegomyia fasciata). Typhoid fever is transmitted through the food and drink becoming contaminated : flies may aid in this con- tamination. 4. Period of Quarantine for: (a) Scarlet fever: till the patient is quite free from sore throat or discharges of any kind, and the desquamation has entirely disap- peared; generally six to eight weeks. ^ (b) Diphtheria: ^11 the patient is free from all signs 339 MEDICAL RECORD. of congestion or rhinitis, and continued bacteriological ex- amination is persistently negative. (c) Smallpox: till all crusts or scabs have entirely dis- appeared. 5. Simple plan of ventilation: Raise the lower sash of a window by an accurately fitting piece of wood, so that a corresponding space is left between the meeting-rails in the center of the window ; through this space fresh air enters, and is directed towards the ceiling. There is thus ventilation without draught. STATE BOARD EXAMINATION QUESTIONS. State Board of Health of Mississippi. ANATOMY. 1. Through what arteries is the collateral circulation carried on after ligation of the femoral below Scarpa's triangle ? 2. In amputation of the forearm three inches above the wrist, what arteries will it be necessary to tie, and of what are they branches? 3. Name the ganglia connected with the fifth pair of cranial nerves. 4. Name the muscles that move the humerus (a) for- ward, (b) backward, (c) inward. 5. Describe the diaphragm, its principal openings, and its nerve supply. 6. What bones make up the pelvis? Describe each. 7. Locate and describe the bladder. 8. Name the bones of the ankle joint and give their relations. PHYSIOLOGY. 1. What are the causes of the apex beat of the heart? 2. Mention the muscles brought into play during the act of deglutition. 3. Describe the function of the ileocecal valve. 4„ What effect have strong alcoholic stimulants on the gastric juice? 5. How are the vocal sounds produced? 6. How does the impairment of the function of the kidneys affect that of the skin and lungs? 7. What is the function of the glossopharyngeal nerve? 8. What are the uses of perspiration? MATERIA MEDIC A. i. Give two derivatives of morphine used in medicine, with dose of each. 2. What are the sources of salicylic acid? 340 MEDICAL RECORD. 3. What is the source of carbo ligni, and what are its therapeutic uses? 4. Give the composition of (a) black wash, (b) Dover's powders. 5. Name six drugs containing large quantities of tannic acid. 6. Name and describe three antiseptics useful for in- ternal administration. 7. Name three animal oils, three vegetable oils, and source of each. 8. Give dose and physiological action of tincture of the chloride of iron. CHEMISTRY. 1. How many elements are there? 2. Describe two experiments showing difference between chemical and mechanical action. 3. Explain difference between metals and non-metals. 4. What are chlorides, bromides, and iodides? Give an example of each. 5. Name and describe an allotropic form of oxygen, and give the symbol. 6. Give the molecular weight, atomic and molecular volume, and density of oxygen. 7. What percentage of C0 2 exists normally in the at- mosphere, and what percentage is dangerous to life? 8. What is chloroform chemically, and how is it made? HYGIENE. i. Mention six desirable factors in the location of a resort for consumptives. 2. What deleterious gases accumulate in an improperly ventilated sleeping room? 3. How do nitrites and nitrates get into water, and will their presence condemn it for drinking purposes? 4. What physical conditions would render the taking of a Turkish bath dangerous? 5. What gases are most efficient as disinfectants, and how would you prepare the room? 6. What abnormal condition of the eyes is most common in school children, and what habits tend to produce it? 7. What are toxins, antitoxins, and how are antitoxins obtained? 8. What is meant by natural, and acquired immunity? Give an example of each. PATHOLOGY. 1. What histological changes occur in acute simple in- flammation? 2. What are the joint changes in arthritis deformans? 3. How do typhoid and tuberculous ulcers of the in- testines differ? 34i MEDICAL RECORD. 4. What conditions predispose to cerebral hemorrhage? 5. Name the diseases in which you would expect to find spleen enlargement. 6. Differentiate hematuria and hemoglobinuria, and give the cause of each. 7. Give the pathology of acute anterior poliomyelitis. 8. What inflammatory conditions result in enlargement of the lymphatic glands? OBSTETRICS. 1. Describe the fully developed ovum. 2. What is the composition of the liquor amnii? Give its uses. 3. Describe the development of the placenta. 4. What changes occur in the uterus during pregnancy? 5. Give cause and treatment of vomiting of pregnancy. 6. When and how would you induce premature labor? 7. What complications of pregnancy justify an ab- dominal section? 8. Name the various conditions which retard or obstruct labor. SURGERY. i. Give indication for ligation of an artery in its con- tinuity. 2. What symptoms follow division of the radial nerve? 3. Mention the possible obstacles to the reduction of a dislocation. 4. Give principles of treatment of compound dislocation 5. Give cause and treatment of delayed union in fracture. 6. Classify wounds. 7. What are the symptoms of cholecystitis? 8. What is a tumor? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. State Board of Health of Mississippi. ANATOMY. i. The collateral circulation after ligature of the femoral artery below Scarpa's triangle, in .Hunter's canal: (1) The external circumflex; with the lower muscular branches of the femoral, anastomotica magna, superior articular of the popliteal, and anterior tibial recurrent. (2) The perforat- ing and terminating branches of the profunda; with mus- cular branches of the femoral, and muscular and superior articular branches of the popliteal. (3) The comes nervi ischiadici; with the perforating branches of the profunda, and the articular branch of the popliteal. 342 MEDICAL RECORD. 2. In amputation of the forearm three inches above the wrist, the radial, ulnar, anterior interosseous, and posterior interosseous arteries should be tied. The radial and ulnar are branches of the brachial ; the anterior and posterior interosseous are branches of the interosseous (which is a branch of the ulnar). 3. The ganglia connected with the fifth pair of cranial nerves: Gasserian, lenticular, Meckel's, submaxillary, and otic. 4. The humerus is moved (a) forward by Pectoralis major, anterior fibers of Deltoid, Coracobrachial, and Biceps when forearm is flexed, (b) Backward, by Latis- simus dorsi, Teres major, posterior fibers of the Deltoid, and Triceps when forearm is extended, (c) Inivard, by Subcapularis, Latissimus dorsi, Teres major, and Pectora- lis major. 5. The diaphragm is a musculofibrous septum which divides the thoracic from the abdominal cavity; it is fan- shaped; the broad, eliptical portion is horizontal, and the crura are vertical. It is attached to the ensiform, to the internal surfaces of the lower six costal cartilages, to bodies and intervertebral substances of first, second, and third lumbar vertebrae. The openings in the diaphragm are : The aortic, the esophageal, for the inferior vena cava, right crural, and left crural. The nerves which supply the diaphragm are : The phre- nics, the lower intercostals, and the phrenic plexus of the sympathetic. 6. The pelvis is made up of : Sacrum, Coccyx, and two ossa innominata (each of which consists of Ilium, Ischium, and Pubis). 7. The bladder. "Position: — In infancy it lies in the abdomen. In the adult it lies in the pelvis behind the pubes ; in the male in front of the rectum; in the female it is placed in front of the uterus and vagina. The apex is connected to the umbilicus py the urachus and by the ob- literated hypogastric arteries, the part posterior to the urachus being covered with peritoneum. The body is un- covered anteriorly by peritoneum, and in front are the triangular ligament, the symphysis pubis, puboprostatic ligaments, and the internal obturator muscles. Superiorly it is covered by peritoneum in the upper part, and is in relation with the rectum in the male, and uterus in the fe- male, and with small intestines in both. < Crossing obliquely on each side of the bladder is the obliterated hypogastric artery, which forms the lateral limit of the peritoneum ; the vas deferens crosses obliquely the lower part of the lateral surface along the inner side of the ureter and ob- literated hypogastric artery. The base or fundus is di- 343 MEDICAL RECORD. rected backwards and downwards. The cervix or neck of the bladder is the part continuous with the urethra, and is embraced in the male by the prostate. There are two sets of ligaments of the bladder— true and false. The true liga- ments are two anterior and two posterior. These are formed of recto-vesical fascia. The urachus is usually described as the 5th or superior true ligament. The false ligaments, five in number, are formed of peritoneum ; there are two posterior, two lateral, and an anterior, the latter covering the urachus. Interior of the Bladder. — Upon the inner surface of the base of the bladder, just behind the urethral orifice, is a triangular smooth surface or trigone, with the apex looking forwards. It is bounded laterally by two ridges passing to the openings of the ureters, the posterior angles being formed by those openings, placed \y 2 inches apart; at its apex there is an elevation, formed by the prostate, called the uvula vesica, which is i 1 /* inches from the ureters. The mucous membrane over the trigone is smooth, but everywhere else elevated upon the irregu- lar muscular wall and rugose." — {Aids to Anatomy.) 8. The bones forming the ankle joint are: Above the lower ends of the tibia and fibula, with the two malleoli (the external from the fibula and the internal from the tibia) ; the above form a mortise to receive the upper convex surface of the astragalus. PHYSIOLOGY. 1. The apex beat of the heart is caused by the sudden hardening of the left ventricle during its systole, and by the heart twisting slightly upon its axis, the apex being brought more forward at the same time. 2. The muscles brought into play during the act of de- glutition are : The hyoglossi, styloglossi, palatoglossi, palatopharyngei, azygos uvulae, tensores palati, levatores palati, stylopharyngei, stylohyoids, geniohyoids, mylo- hyoids, thyrohyoids, digastrics, constrictors of the pharynx, and the muscles of the tongue. 3. The function of the ileocecal valve is to prevent the contents of the large intestine from passing back again into the small intestine ; it is also a barrier against the passage upward of the bacteria which are normally found in the large intestine. 4. Alcohol "promotes the absorption of accompanying substances (sugar, peptone, potassium iodide), and stimu- lates the flow of the gastric juice. In this matter it acts as do other condiments (salt, pepper, mustard, peppermint), but if there be too great an irritation of the mucous mem- brane there is less activity (dyspepsia). The rapid absorp- tion gives to alcohol its quick recuperative effect after collapse, and its value in administering drugs, especially 344 MEDICAL RECORD. antidotes. Alcoholic beverages combining alcohol and flavor promote gastric digestion and absorption, but often stimulate the appetite in excess of normal requirements. Alcohol is burned in the body, but may also be found in the breath, perspiration, urine, and milk." — (American Text-Book of Physiology.) Excessive use of alcohol causes an increase in the acid- ity, quantity, and total solids of the gastric juice; pepsin is precipitated, albumin is coagulated, and proteid diges- tion is retarded or inhibited ; the movements of the ali- mentary canal are accelerated ; vomiting and diarrhea may be produced. 5. The vocal sounds are produced by an expiratory blast of air being forced through the narrow chink between the true vocal cords. The current of air sets these vocal cords in vibration, and these vibrations are communicated to the air in the upper air passages. The pitch of the sound produced depends upon the rapidity with which the vocal cords vibrate. 6. Impairment of the function of the kidneys throws more work upon the skin, which it can only partially per- form ; some of the work must also be performed by the lungs. If severe or long continued, death ensues from autointoxication. 7. The function of the glossopharyngeal nerve is: (1) Taste, to posterior part of tongue and palate; (2) sensa- tion to mucous membrane of pharynx, fauces, and tonsil; it is also claimed that it is (3) motor to the constrictors of the pharynx. 8. The uses of perspiration are : Excretion of water, carbon dioxide, and urea ; cooling of surface of body, and regulator of heat of body. MATERIA MEDIC A. 1. Tzvo derivatives of morphine: (1) Codeine, dose, gr. 1/2. (2) Apomorphine hydrochloride, dose, gr. 1/10 (emetic). 2. Sources of salicylic acid: (1) Oil of wintergreen ; (2) salicin ; (3) synthetically, from sodium phenate and carbon dioxide. 3. The source of Carbo ligni is soft wood, charred without access of air. Its therapeutic uses are : For flatu- lence; as a mild laxative, deodorant, and absorbent. 4. (a) Black wash is made of calomel 3j to one pint of lime water. (b)Dover's powder is a mixture of ten parts of powdered opium, ten parts of ipecac, and eighty parts of sugar of milk. 5. Six drugs containing tannic acid in large quantities: Gambir, krameria, haematoxylon, hamamelis, geranium, and chimaphila. 345 MEDICAL RECORD. 6. Three antiseptics for internal administration: (i) Urotropin; colorless, odorless, crystalline : soluble in about equal parts of water; it inhibits the growth of microorgan- isms by reason of the formaldehyde which it yields up in the body in the urine ; part of it is excreted unchanged and part as formaldehyde. (2) Salol; a white crystalline pow- der, very soluble in hot alcohol, but almost insoluble in water ; it is decomposed into carbolic acid and salicylic acid. (3) Naphthalene: characteristic odor, aromatic taste, colorless, insoluble in water. 7. Three Animal oils: (1) Cod liver oil, from the liver of the cod; (2) Lard oil, from lard (from internal fat of the hog) ; (3) Neat's-foot oil, from the feet of neat cattle. Three Vegetable oils: (1) Castor oil, from Ricinus com- munis; (2) croton oil, from croton tiglium; (3) olive oil, from ripe fruit of olea europoea. 8. Tincture of the chloride of iron: Dose, eight minims. Physiological action: astringent, hemostatic, gastrointestinal irritant, hsematinic, and tonic. CHEMISTRY. 1. There are eighty elements. 2. "A bar of soft iron may be made to emit light when heated, or sound when caused to vibrate, or magnetism when under the influence of an electric current. Under the influence of these physical forces the iron suffers no change in composition, and, on cessation of the action of the inciting force, the iron returns to its original condition. But if the iron be heated in an atmosphere of oxygen, both the iron and a part of the oxygen disappear, and a new substance, a new chemical species, is produced, having properties of its own, different from those of either the iron or the oxygen. In this case there has been chemical action, causing change of composition, as the new sub- stance contains both iron and oxygen. The result of such action is, moreover, permanent, and the new product con- tinues to exist, until modified by some new manifestation of chemical action."— (Witthaus' Manual of Chemistry.) 3. The metals are all solid (except mercury), opaque, have metallic luster, are good conductors of heat and elec- tricity, and will replace the hydrogen of acids to form salts. Nonmetals do not have the above properties, some are gases, and their properties differ widely among the different elements. 4. Chlorides, bromides, and iodides are binary compounds of chlorine, bromine, and iodine, respectively. Example: Sodium chloride, NaCl ; potassium bromide, KBr; potas- sium iodide, Kl. 5. Allotropic form of oxygen is ozone. When pure, it is a dark blue liquid, almost opaque, it is a strong oxidizing 346 MEDICAL RECORD. agent; it oxidizes nearly all metals in the presence of moisture; it decolorizes organic pigments. Symbol is O a . 6. Oxygen. Molecular weight, 32; atomic volume is the atomic weight divided by the specific gravity; molecular volume, 22.4 ; density, 32. 7. In air there is 0.04 per cent, of carbon dioxide. The* percentage dangerous to life depends upon the amount of oxygen present; probably 10 per cent, in the atmosphere would prove fatal. 8. Chloroform is a substitution product of methane. Three of the four hydrogen atoms of methane are replaced by three atoms of chlorine; hence the formula is CHCU, and the proper name would be Trichlormethane. Chloroform can be obtained by heating chloral hydrate with an alkali: GHCl.(OH), + KHO = CHC1 3 + HCOOK + H 2 It is prepared on a large scale by the action of bleaching powder upon acetone : 2CO(CH 8 ) 2 + 6CaCl(OCl) = 2CHCI. + 2Ca(OH) 2 + Ca(CHs. COO), + 3CaCl». HYGIENE. 1. Six desirable factors in the location of a resort for consumptives: (1) Pure and dry air, free from dust; (2) equable temperature; (3) protection from high winds; (4) dry soil; (5) high altitude; and (6) plenty of sunlight. 2. Deleterious gases which accumulate in an improperly ventilated sleeping room: Carbon dioxide, carbon monox- ide, methane, sulphur dioxide, hydrogen sulphide, ammo- nium sulphide, ammonia, and organic vapors from decom- posing animal matter. 3. Nitrates are generally due tc the oxidation of organic matter of animal origin. Nitrites generally indicate sewage contamination. The presence of nitrites should condemn the water ; so should a marked amount of nitrates. 4. Organic heart disease, obesity, cirrhosis of kidney or liver, and arterio-sclerosis. 5. The most efficient gaseous disinfectants are: Formal- dehyde, sulphur dioxide, and chlorine. All apertures or crevices must be carefully closed, so that the gas used may remain as concentrated as possible. 6. Myopia is the most common abnormal condition of the eye in school children. Habits tending to produce it are : Reading of fine or indistinct print, reading in poor illumination, improper posi- tions in reading or writing, using the eyes when tired, and excessive study. 7. Toxins are harmful or poisonous products of bacteria. Antitoxins are substances formed in the body, of a pro- 347 MEDICAL RECORD. tective character, and capable of rendering inert the poison- ous products of bacteria. 'The methods used in the production of antitoxins were introduced by Behring, who found that by injecting susceptible animals with increasing amounts of extracel- lular toxin he produced in the blood-serum of the injected animal certain changes which made the serum capable of counteracting the same toxin when injected into other animals. ... In practice, the bacilli are cultivated in bouillon. The cultures are freed from all living bacilli by filtration. The liquid filtrate contains the toxin. This filtrate is injected into healthy susceptible animals, in in- creasing doses. Usually the horse is used, since large quantities of blood can be drawn from this animal on account of its size, and, moreover, the horse is very sus- ceptible. . . . Eventually enormous doses of toxin are given, and the animal acquires a high degree of immunity. The blood of the animal is withdrawn, taking care to avoid contamination, and the serum allowed to separate in the refrigerator. The serum of the blood is drawn off and constitutes the antitoxin." — (Williams' Bacteriology.) 8. Immunity is the power of resistance of cells and tis- sues to the action of pathogenic microorganisms. Im- munity may be either natural or acquired. Natural immunity is that power of resistance, natural and inherited, and peculiar to certain groups of animals, but common to every individual of these groups. Acquired immunity is this resistance acquired (i) by a previous attack of the disease, or (2) by the person being made artificially insusceptible. The conditions which give immunity are: (1) a previous attack of the disease; (2) inoculation with the specific microorganisms in small num- bers or of diminished virulence, so as to produce a mild attack of the disease; (3) vaccination; (4) the introduc- tion of antitoxins; (5) the introduction of the toxins of the bacteria. Examples. — The rat is naturally immune to anthrax; the white mouse is naturally immune to infection with bacillus mallei. Acquired immunity is seen in the immunity from smallpox after vaccination, or after having suffered from an attack of the disease. PATHOLOGY. 1. The phenomena of inflammation are dilatation of the arterioles, capillaries, and small veins. At first the blood current is quickened, then retardation occurs, and may progress to stasis and thrombosis. During this time exudation of plasma and white corpuscles from the small veins, and perhaps the capillaries, is going on. The fate of the white cell may be either to break up and set free pro- thrombin, or to act as food for connective tissue cells, or 348 MEDICAL RECORD. to act as a phagocyte and be transformed into a pus corpuscle. Red corpuscles may be exuded and broken up, setting free their coloring matter. The prothrombin of the white cells unites with the calcium chloride of the plasma, and forms thrombin, or fibrin ferment, which acts upon the fibrinogen of plasma to form fibrin. The tissues are thus invaded with numbers of leucocytes. In bacterial inflammation a varying portion of the tissues is killed by the toxins produced, and is either replaced by a mass of small round cells, or liquefied into pus. In the latter case it is surrounded by a ring of small round cells. The connective tissue cells absorb the leucocytes, and new vessels are formed, thus constituting repair. In nonbac- terial inflammation, exudation may separate layers of cells to a large extent and form blebs. In chronic inflammation the formation of new fibrous tissue is the chief part of the process. — (From Aids to Surgery.) 2. The joint changes in arthritis deformans are: Pro- liferation of the cartilage cells, the edges of the cartilage become fibrillated and wear away; the underlying bone becomes hard and polished, and later atrophies in parts, part of the bone becomes absorbed ; ossification may also occur, with locking of the joint; the synovial membrane may either atrophy or hypertrophy. 3. In the typhoid ulcer: (1) The main axis of the ulcer lies parallel with that of the intestine ; (2) it lies opposite to the mesenteric attachment; (*) it has smooth floor and undermined edges ; (4) it commonly leads to perforation. In tubercular ulcer: (1) The long axis of the ulcer lies at right angles to that of the intestine ; (2) it is not neces- sarily situated opposite the mesenteric attachment; (3) its floor is not smooth nor are its edges undermined. 4. The conditions which predispose to cerebral hemor- rhage are : Advanced age, rheumatism, gout, syphilis, alco- holic excesses. Bright's disease, prolonged muscular exer- tion, chronic lead poisoning, severe physical or mental excitement. 5. Spleen enlargement may be found in: Typhoid fever, malaria, leukemia, pernicious anemia, cirrhosis of liver, and many of the infectious diseases (diphtheria, scarlet fever, erysipelas, pneumonia) and septic processes (septice- mia and pyemia). 6. Hematuria is blood in the urine. Hemoglobinuria is blood pigment in the urine. In hematuria a microscopical examination will show numerous red blood corpuscles in the urine ; in the other condition red cells are either absent or are very scanty. The principal causes of hematuria are: (1) Conditions in which the blood is affected, as in the infectious diseases, in scurvy, pernicious anemia, and purpura; (2) traumatism 349 iMEDICAL RECORD. or inflammations in any part of the urinary tract; (3) con- gestion of the kidneys secondary to disease of the lungs, heart, or liver. The principal causes of hemoglobinuria are: Poisons, such as arsenic, potassium chlorate, carbolic acid, carbon monoxide; jaundice, malaria, syphilis, Raynaud's disease, scurvy, purpura. 7. In acute anterior poliomyelitis: Congestion and then destruction of the ganglion cells in the anterior horns of the spinal cord; there is an infiltration of leucocytes; and an overgrowth of connective tissue replaces the cells in the anterior horns. The fibers of the anterior roots show de- generation ; the posterior roots are not affected. 8. Inflammatory conditions which may result in enlarge- ment of the lymphatic gland: Tonsillitis, gonorrhea, chan- croid, syphilis, septic infections. OBSTETRICS. i. The ovum when fully developed is a single cell, spher- ical, about 1/125 inch in diameter; it is composed of a yolk, with nucleus, nucleolus, and two enveloping mem- branes. 2. The liquor amnii is the fluid contained in the amniotic sac ; it is alkaline in reaction, has a specific gravity of about 1. 001 to 1.008, its quantity is variable, but is generally about two pints. It consists chiefly of water, but contains small amounts of albumin, epithelial cells, urea, phosphates, chlorides, etc. Its source is unsettled. Functions: (a) During Pregnancy: (1) As a protection to the fetus against pressure and shocks from without. (2) As a protection to the uterus from excessive fetal move- ments. (3) It distends the uterus, and thus allows for the growth and movements of the fetus. (4) It receives the excretions of the fetus. (5) It surrounds the fetus with a medium of equable temperature, and serves to prevent loss of heat. (6) It prevents the formation of adhesions be- tween the fetus and the walls of the amniotic sac. (7) It has been supposed, by some, to afford some slight nutrition to the fetus. (b) During Labor: It acts as a fluid wedge, and dilates the os uteri and the cervix; it also slightly lubricates the parts. 3- See Williams' "Obstetrics" (1909), page 128; or Hirst's "Obstetrics" (1909), page 120. 4. See Williams' "Obstetrics" (1909), page 164; or Hirst's "Obstetrics" (1909), page 180. 5. Causes of vomiting in pregnancy are: (1) Reflex dis- turbance, due to rapid growth and excessive distention of the uterus ; (2) disease or displacement of uterus, tubes, and ovaries; (3) disease of pelvis or gastrointestinal tract; 350 xMEDICAL RECORD (4) excessive sexual intercourse; (5) renal disease or disturbance. 6. Conditions warranting the induction of premature labor: (1) Certain pelvic deformities, (2) placenta praevia, (3) pernicious anemia, (4) toxemia of pregnancy, (5) habitual death of the fetus toward the end of pregnancy, (6) hydatidiform mole, (7) habitually large fetal head. The methods that may be employed are : Partial dilata- tion of the cervix and the introduction within the cervix (and vagina) of a tamponade of sterile gauze; (2) dilata- tion of the cervix; (3) puncturing the membranes; (4) in- troduction of a sofc rubber bougie into the uterus; (5) in- trauterine injection of glycerin, water, or some other fluid. 7. The absolute indications of cesarean section are: Ex- treme pelvic contraction or deformity in which delivery by forceps or version or symphyseotomy is impossible, and in which craniotomy is either impossible or would be more dangerous to the mother; the presence of extreme atresia of the vagina; rupture of the uterus; sudden maternal death. 8. Conditions which retard or obstruct labor: Rigidity, edema, atresia, or displacement of the os or cervix; fibrous bands, or atresia of vagina; persistent hymen; unyielding perineum; tumors; distended bladder or rectum; hernia; edema of labia; pelvic deformities; malpositions or mal- presentations of the fetus; prolapse of limbs ; short cord; large fetus ; dead fetus ; twins or monstrosities ; uterine inertia; rupture of uterus. SURGERY. 1. The indications for ligation of an artery in its con- tinuity are: To check hemorrhage, to promote the cure of an aneurysm, to diminish the rate of growth of a tumor, to cause atrophy of an organ by diminishing its blood supply, as a preliminary to removing some vascular struc- ture (such as the tongue). 2. Division of the- radial nerve would be followed by : Loss or impairment of sensation in the dorsal aspect of thumb, index finger, and radial side of middle finger as far as the second phalanx. 3. The possible obstacles to reduction of a dislocation are : Torn capsule embracing the neck of the bone, mus- cular contraction, interlocking of bony points ; inflammatory swelling of the soft parts, and tendons or muscles catching around the neck of the displaced bone. 4. Principles of treatment in compound dislocations: Open up the wound if there is any chance of its being in- fected, remove destroyed tissue, irrigate thoroughly, re- duce the dislocation, pack with gauze, drain, and im- mobilize. 351 MEDICAL RECORD. 5. Delayed union in fracture is caused by: 111 health, want of approximation of the end of the bone, want of blood supply in the bone, defective innervation of the bone, disease of the bone, lack of rest, and immobility. Treatment: "When delayed union exists, seek and remove cause treating constitutionally if required, and thoroughly immobilizing the parts by plaster. Orthopedic splints may be of value. Use of the limb while splinted, percussion over the fracture, and rubbing the fragments together, thus in each case producing irritation, have all been recommended. Blistering the skin with iodine or firing it has been em- ployed. If the case be very long delayed, forcibly separate the fragments and put up in plaster as a fresh break. If these means fail, irritate by subcutaneous drilling or scrap- ing, or, better, by laying open the parts and then drilling and scraping at many places." (Da Costa.) 6. Wounds are classified as: (1) Contused and open. (2) Open wounds may be : Incised, lacerated, contused, punctured, gunshot, or poisoned; also penetrating and per- forating. (3) Aseptic and septic. 7. Symptoms of cholecystitis: Pain and tenderness in region of gall-bladder'; fever, rapid pulse, vomiting, rigid abdominal muscles, jaundice may be present. 8. A tumor is a pathological new growth which tends to persist independently of the tissues in which it is found, and which serves no physiological purpose. STATE BOARD EXAMINATION QUESTIONS. Missouri State Board of Health. anatomy. 1. Describe superficial and deep palmar arch; how formed? Give landmarks. 2. Name all muscles that elevate the arm at shoulder joint, giving origin and insertion of same._ 3. Give minute and gross anatomy' of kidneys. 4. Give minute and gross anatomy of pleura. 5. Give origin, ending, branches, and relationship of pos- terior tibial artery. 6 Describe the tibia, giving points of ossification. With what bones does it articulate? 7. Draw cross section amputation of forearm, middle third, naming structures divided. 8. Give origin, course, exit, and parts supplied by the second pair of cranial nerves. 9. Describe anterior triangle of neck, how formed, giv- ing contents. 10. Describe the spinal column, giving characteristics of vertebra in each division. 352 MEDICAL RECORD PHYSIOLOGY. i. State the general character and physiological action of the hydrocarbon and albuminoid substances. 2. Give mode of secretion and composition of the gastric juice. 3. Give physiological action of the saliva. 4. Describe the blood and give the composition of the red and white globules. 5. Explain the cause of coagulation of the blood and its usefulness. 6. Give the composition of the urine and state which constituent is the most important. 7. State the most important function of the medulla oblongata as a nervous center, with full explanation of same. 8. Name and give function of first pair of cranial nerves. 9. Give origin and function of fifth pair of cranial nerves. 10. State the general arrangement and function of the sympathetic nervous system. CHEMISTRY. i. Describe and state the physical and chemical proper- ties of oxygen. 2. Give the chemical formula for potassium iodide, and state how it is made. 3. Name the four elements known as Halogens, and de- scribe each. 4. Give chemical formula for phenic acid. From what derived? For what purpose used in medicine? Give treat- ment for toxic dose. 5. Give chemical formula for sulphuric acid. How ob- tained? Give toxic dose. For what purpose used in medi- cine? BACTERIOLOGY. 1. Describe the process of producing diphtheria anti- toxin. 2. Give theory of immunity produced by vaccination. 3. What diseases confer immunity by vaccination or innoculation? 4. Give the technique for staining for the pneumococcus. 5. Describe in detail process of finding tubercle bacilli in a specimen of urine. PATHOLOGY. 1. What is aortic stenosis? Give pathology. 2. What is the pathological condition found in chronic Bright's disease? 3. Give the pathology in specific iritis. 353 MEDICAL RECORD. 4. What pathological conditions are found in acute ca- tarrhal dysentery? 5. Give pathology of chronic gastritis. THERAPEUTICS. l> Name the officinal preparations of opium. Give dose and therapeutic uses. 2. Give the physiologic action and therapeutic uses of colchicum. 3. Give the dose and therapeutic indications for bryonia. 4. Name the onicinal preparations and give therapeutic uses of calcium phosphate. 5. Give the dose and therapeutic uses of veratrum. 6. Give the dose, physiologic action, and therapeutic uses of ipecac. 7. Name the officinal preparations, give the dose and therapeutic uses of nux vomica. 8. Give the dose and therapeutic indications for tartar emetic. a Give the dose and therapeutic indications for aconite. (Jp. Name the officinal preparations of cinchona. Give dose and therapeutic uses. PRACTICE. 1. Give etiology, exciting cause, and treatment of variola. 2. What are the methods of physical diagnosis, and what phenomena are obtained by these methods? 3. Give etiology, symptoms, and treatment of lobar pneu- monia. 4. What are the physical signs of incipient pulmonary tuberculosis? What is the treatment? 5. What is the etiology and treatment of typhoid fever? 6. Give the symptoms and treatment of acute bronchitis. 7. What are the symptoms of acute Bright's disease, and how should it be treated? 8. W r hat is a cataract, and how would you treat it? 9. How would you diagnose a case of non-suppurative otitis media? What is the treatment? 10. What are the conditions found in psoriasis? What is the proper treatment for same? OBSTETRICS. 1. Describe pregnancy from ovulation to maturity of fetus, giving mechanism of delivery in an L. O. A. pres- entation. 2. Describe placenta praevia, giving varieties, causes, diag- nosis, and treatment. 3. Differentiate hand from foot, knee from elbow, shoul- der from vertex. Give management of shoulder presen- tation. 354 MEDICAL RECORD. 4. Define eclampsia, giving etiology, prognosis, and treat- ment. 5. When should chloroform be used in labor? Ditto ergot? Give advantages and dangers of each. 6. When should forceps be used? Give manner of apply- ing the same, with mechanism of delivery after application, selecting your own presentation. 7. Differentiate false from true labor pains. Give stages of labor and what occurs during each stage. 8. Describe asphyxia of new born, giving varieties and treatment. 9. Give your method of caring for the new born from birth until it is dressed. 10. Give signs of pregnancy at third and sixth months. GYNECOLOGY. 1. Define vulvitis. Give varieties, causes, and treatment. 2. Define vaginitis, giving varieties, causes, and treat- ment. 3. Define menstruation. Xame disorders of same, giving usual causes and treatment of each. 4. Define metritis. Give varieties, causes, and treatment of each. 5. Give differential diagnosis in inversion, polypi, pro- lapsus uteri, and method of treating each. SURGERY. 1. Give differential diagnosis between brain abscess and brain tumor. 2. Describe an operation for cure of femoral hernia. 3. Give symptoms and treatment of acute osteomyelitis. 4. Give diagnosis between gastric cancer and ulcer. 5. What is the treatment . of gunshot wound of the knee from a revolver wound? 6. Give the signs and symptoms of tuberculosis of the kidney. 7. Differentiate between an old dislocation and tubercu- losis of hip joint. 8. What is the best treatment for a fracture about the elbow joint? Why? 9. Give signs and symptoms of intussusception. 10. What operation do you consider profitable for removal of prostrate gland? Give reasons. HYGIENE. 1. Give etiology and prophylaxis of ophthalmia neona- torum. 2. Discuss etiology, prophylaxis and nygienic care of cholera infantum. 3. Name three infections transmitted through air; MEDICAL RECORD. through water; through food; through insects. Give prophylaxis. 4. Give period of incubation, length of quarantine and hygienic care of the following diseases: Smallpox, scarla- tina, diphtheria, measles. 5. Discuss vaccination and antitoxine, giving brief his- tory of each, and value of same. MEDICAL JURISPRUDENCE. i. What evidence would you look for to distinguish cerebral concussion' from intoxication? 2. What evidences determine a recent from an old cerebral hemorrhage? 3. What is malpractice — civil, and criminal? 4. In case ^ of drowning, how would you determine whether homicidal, suicidal, or accidental? 5. In case of hanging, what circumstantial evidence would you look for, to determine whether the act wns homicidal, or suicidal? 6. Where a question arises as to personal identity, «n what manner, or by what tests would you determine it? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Missouri State Board of Health. anatomy. 1. The superficial palmar arch is formed by the ulnar artery, and is completed by the ulnar artery anastomosing with a branch of the radial (superficial volar or princeps pollicis). It gives off the four digital branches. The surface marking is a line drawn transversely across the palm from a point where the web of the thumb joins the palm. The deep palmar arch is formed by the radial ar- tery, and is completed by the radial artery anastomosing with a deep branch of the ulnar. Its branches are the pal- mar interosseous, perforating, and palmar recurrent ar- teries. The surface marking is a line drawn transversely across the palm, one-half inch nearer the wrist than the superficial arch. 2. Muscles that elevate the arm at the shoulder are: Deltoid and supraspinatus. Deltoid. Origin: From the outer third of anterior border and upper surface of the, clavicle, from the outer margin and upper surface of the acromion process, and from the lower edge of the spine of the scapula. Inser- tion: Into the deltoid impression on the middle of the outer side of the shaft of the humerus. Supraspinatus. Origin: From the supraspinatus fossa 356 MEDICAL RECORD. and fascia. Insertion: Into the great tuberosity of the humerus. 3. See Cunningham's "Anatomy" (1909), pages 1130 and 1138; or Gray's "Anatomy" (1908), pages 1419, 1423, and 1426. 4. See Cunningham's "Anatomy" (1909), page 977; or Gray's "Anatomy" (1908), pages 1391 and 1395. 5. The posterior tibial artery is the continuation down- ward of the popliteal artery. It begins at the lower border of the popliteus muscle; it ends midway between the in- ternal malleolus and the tuberosity of the os calcis, where it divides into the external and internal plantar arteries. Its branches are: Peroneal, nutrient, muscular, cutaneous, communicating, internal calcanean, and malleolar cutane- ous. Relationships. In front: Tibialis posticus, flexor longus digitorum, tibia, and ankle joint. Behind: Skin, fascia, gastrocnemius, soleus, posterior tibial nerve, and abductor hallucis. On inner side: Posterior tibial nerve, at upper part. On outer side: Posterior tibial nerve, at lower part. 6. See Cunningham's "Anatomy" (1909), pages 230 and 234; or Gray's "Anatomy" (1908), pages 234 and 238. 7. In amputation of forearm at middle third there will be severed : Skin, fascia, supinator longus, extensor carpi radialis longior and brevior, extensor communis digitorum, extensor carpi ulnaris, supinator brevis, anconeus, pronator radii teres, flexor carpi radialis, palmaris longus, flexor sublimis digitorum, flexor carpi ulnaris, flexor profundus digitorum ; arteries : ' anterior interosseus, radial, ulnar ; veins : radial, interosseous, ulnar, median ; nerves : pos- terior interosseous, radial, median, ulnar ; bones : radius, ulna. 8. See Cunningham's "Anatomy" (1909), page 675; or Gray's "Anatomy" (1908), page 1038. 9. The anterior triangle of the neck is bounded: In front by a line from the chin to the sternum; behind by the anterior margin of the sternomastoid ; base is upward, and is formed by the lower border of the body of the lower jaw and a line from the angle of the jaw to the mastoid process. It is divided into three smaller triangles (inferior carotid, superior carotid, and submaxillary) by the digastric muscle and the anterior belly of the omo- hyoid. Contents: Thyroid gland, trachea, larynx, parotid and submaxillary glands. Arteries : Inferior thyroid, com- mon carotid, internal carotid, external carotid, superior thyroid, lingual, facial, ascending pharyngeal, occipital, submental, and mylohyoid. Veins: Inferior thyroid, in- ternal jugular, lingual, facial superior thyroid, pharyn- geal, external jugular, and anterior jugular. Nerves: Pneumogastric, recurrent laryngeal, descendens noni, com- 357 MEDICAL RECORD. municans noni, superior laryngeal, external laryngeal, spinal accessory hypoglossal, glossopharyngeal, mylohyoid, and sympathetic. Also lymphatic glands and vessels. 10. See Cunningham's "Anatomy" (1909), pages 75, 78, 81, 83, and 88; or Gray's "Anatomy" (1908), pages 48, 49> 53, 56, and 67. PHYSIOLOGY. i. Hydrocarbons consist of carbon and hydrogen only; as a rule they are not used as food, and have no particular physiological action. The term was often used loosely to denote fats (containing carbon, hydrogen, and oxygen) whose function is to supply heat and energy, and to serve in the nutrition of the nervous system. Albuminoids are a miscellaneous collection of proteins which are neither albumins nor proteids; they are generally insoluble in the neutral solvent of the proteins; they are found in connective tissues, cartilage, bone, skin. 2. Secretion of Gastric Juice: "The stomach has two secretions, one thick, tenacious, and alkaline — the gastric mucus; the other, thin, acid, and watery — the gastric juice proper. The former is secreted during fasting, while the latter is only secreted when food or fluid enters the stom- ach. Saliva or alkalies, pepper, alcohol excite the secre- tion of gastric juice. Their action is reflex; the vagus is probably the afferent nerve, which, acting on the me- dulla, inhibits the sympathetic and dilates the blood-vessels supplying the glands; the efferent impulses descending along the splanchnics." — (Ashby.) The constituents of gastric juice are : Water, proteid, mucin, pepsin, rennin, hydrochloric acid, salts (sodium and potassium chlorides, and calcium and magnesium phos- phates). 3. The functions of the saliva are: (1) To moisten the mouth, (2) to assist in the solution of the soluble portions of the food, and thus (3) to administer to the sense of taste, (4) to lubricate the bolus of food, and thus (5) to facilitate the acts of mastication and deglutition, and (6) ;o change starches into dextrin and sugar. 4. The blood is fluid, somewhat viscid, red, specific gravity from 1055 to 1062, alkaline reaction, saltish taste, charac- teristic odor, variable temperature (average about ioo° F.). The constituents are plasma and corpuscles. The plasma consists of water and solids (proteids, extractives, and in- organic salts). The red corpuscles consist of water and solids (hemoglobin, proteins, fat, and inorganic salts). The white corpuscles consist of water and solids (protein, leuconuclein, lecithin, histon, etc.). 5. The coagulation of the blood is due to the develop- ment in it of fibrin. In the plasma a proteid substance exists, called fibrinogen. From the colorless corpuscles MEDICAL RECORD. a nucleoproteid is shed out, called prothrombin. By the action of calcium salts prothrombin is converted into fibrin ferment, or thrombin. Thrombin acts on fibrinogen in such a way that two new substances are formed; one of these is unimportant and remains in solution ; the other is important, viz., fibrin, which entangles the corpuscles, and so forms the clot. Its usefulness is seen in the check- ing of hemorrhage. 6. Composition of urine: Water, urea, uric acid, hippuric acid, xanthin, hypoxanthin, creatin, creatinin, extractives ; chlorides, sulphates and phosphates (of sodium and potassium) ; phosphates of magnesium and calcium; nitro- gen, and carbon dioxide. Urea is the most important con- stituent. 7. The medulla is the seat of several special centers, the most important of which is probably the respiratory center. "The respiratory center is in reality made up of two cen- ters, one for each side, so that, although anatomically con- nected and ordinarily acting together, yet if one center is broken up, while the respiratory movements on that side cease, those on the other side continue. Besides this double character of the center, each half is made up of an inspiratory and an expiratory center. The respiratory center is both an automatic and a reflex center — i. e., it sends out spontaneously impulses which result in move- ments of the respiratory muscles, constituting its auto- matism; and it may also be excited reflexly, i.e. by im- pulses reaching it from without. Its reflex character is most marked, and it is doubtless as a reflex center that its function is ordinarily performed." — {Raymond.) 8. Olfactory neves; function is special sense of smell. 9. Trifacial nerve. Origin: — (1) Superficial, from the side of the pons varolii; (2) Deep (sensory root), from the medulla, and upper part of cord; (motor root) from floor of fourth ventricle, and side of the aqueduct of Sylvius. Functions: First ophthalmic branch supplies sensation to conjunctiva and skin of upper eyelid, cornea, skin of forehead and nose, lachrymal glands, mucous membrane of nose. Second, or superior maxillary branch, supplies sensation to skin and conjunctiva of lower lid, nose, cheek, upper lip, upper teeth and alveolar processes, and palate. Third, or inferior maxillary branch, supplies sensation to external auditory meatus, side of head, mucous membrane of mouth; anterior two-thirds of tongue, lower teeth, lower lip, and skin of the lower part of the face. This branch, in addition, supplies motion to the muscles of mastication (masseter, temporal, external pterygoid, interna^ ptery- goid), also mylohyoid and anterior belly of digastric. 10. "The sympathetic nervous system consists of (1) a series of ganglia connected together by a great ganglionic 359 MEDICAL RECORD. cord, the gangliated cord, extending from the base of the skull to the coccyx, one gangliated cord on each side of the middle line of the body, partly in front and partly on each side of the vertebral column; (2) of three great gangliated plexuses or aggregations of nerves and ganglia, situated in front of the spine in the thoracic, abdominal, and pelvic cavities respectively; (3) of smaller or terminal ganglia, situated in relation with the abdominal viscera; and (4) of numerous fibers." Function: It has a controlline influence over the se- cretion of most of the glands, the lacrymal, the salivary, the sweat glands, the glands of the stomach and intestines, the liver, the kidney, etc. ; it presides over the circulation by _ regulating the caliber of the blood-vessels and the action of the heart; it influences respiration; and, all in- voluntary muscles, those of the digestive apparatus, of the genitourinary system, of the hair follicles (pilomotor nerves), are under its control to a great extent. CHEMISTRY 1. Oxygen is the most abundant of the elements ; it occurs free in the air, and in combination in very many substances. It is a colorless, odorless, tasteless gas, slightly soluble in water, heavier than air, combines readily with all other elements except fluorine, supports combustion and respiration, and is necessary to animal life. It has a valence of two, atomic weight of 16, and molecular weight of 32. 2. Potassium Iodide. Formula, KI. Preparation: Saturate an aqueous solution of potassium hydroxide with iodine : 6KHO + 3I2 = KIO3 + 3H 2 + 5KI 3. The four halogens are: Fluorine, chlorine, bromine, and iodine. Fluorine is a very irritant, corrosive gas; it decomposes water, forming ozone and hydrofluoric acid ; it attacks organic substances with vigor; it forms com- pounds with all other elements except oxygen. Valence, one; atomic weight, 19. Chlorine is a greenish yellow gas, occurring only in combination. It has a penetrating odor, and is very irritating. It has a tendency to combine with other elements, sometimes with evolution of light and heat. In the presence of water it is an active bleaching and disinfecting agent. Valence, one; atomic weight, 35.5, Bromine is a dark, reddish-brown liquid, giving off an irritating vapor. It is only found in combination. It is somewhat similar to chlorine, but less active. Valence, one ; atomic weight, 80. Iodine is found in combination ; is a solid, volatile, its vapor has a violet color and peculiar odor; it is scaly, with metallic luster. It is somewhat similar to chlorine and bromine, but is less active. Valence, one; atomic weight, 127. 4. Phenic acid. Formula: CelLOH. Derived from 360 MEDICAL RECORD. coal tar. Used as an antiseptic, disinfectant; as an applica- tion to burns, lupus; as an injection for leucorrhea and gonorrhea in the female ; as an antipruritic. Treatment for toxic dose: Externally, alcohol; internally, sodium sul- phate. 5. Sulphuric acid. Formula: H2SO4. Obtained by combustion of sulphur, and oxidation and hydration of the resulting sulphur dioxide, by vapor of nitric acid and water. Toxic dose: "One dram is the smallest dose reported fatal to an adult. One-half that quantity has caused the death of a child one year old. There is no doubt, however, that as small a quantity as two or three drops of the concen- trated acid would prove permanently injurious, while it might not prove fatal. Recovery has taken place after four ounces when appropriate treatment has been given." — (Riley's Toxicology.) Use in medicine: As a caustic for venereal sores and warts: internally, in serous diarrhea, cholera, acute lead poisoning, and for the night-sweats of phthisis. BACTERIOLOGY. i. "Diphtheria antitoxin is obtained from the horse, the animal having been rendered artificially immune by re- peated injections extending over a period of several months of gradually increasing quantities of the strongest diph- theria toxin. As the bacilli themselves are not injected, the horse does not become infected with diphtheria, but he gradually acquires a tolerance for the toxins of the disease and develops in his blood a substance (antitoxin) which has the power to neutralize those toxins. At the proper time, when it is thought that his blood has acquired the requisite degree of potency, the animal is bled, and the serum — the part of the blood containing the antitoxin — is carefully separated from the clot, filtered, and standardized. The last procedure is accomplished by determining the quantity of antitoxin serum required to offset the effects of the minimum quantity of toxin necessary to kill a guinea-pig in a definite time. The strength of the antitoxin is measured in units, a unit containing the amount of anti- toxin required to save the life of a guinea-pig which has been injected with 100 fatal doses of toxin." — (Stevens' Materia Medica.) 2. The introduction into the body of the vaccine is sup- posed to bring about a reaction, which is evidenced by a marked increase in the bactericidal and agglutinative prop- erties of the blood serum against the particular organism. 3. Smallpox, diphtheria, tuberculosis, bubonic plague, hy- drophobia, cholera, typhoid ; and it has also been tried in some other diseases. 4. To stain the pneutnococcus: Spread a cover glass with 36i MEDICAL RECORD a smear containing the bacteria, dry it, then fix it in a flame. It can then be stained for from five to ten minutes in Ehrlich's solution; it is then to be washed in water and afterwards immersed in Gram's solution for two or three minutes. It is then washed in 95 per cent, alcohol. While in the Gram's solution the specimen is very dark brown, but it becomes violet or blue again on application of the alcohol. 5. To find tubercle bacilli in the urine: The urine should be drawn by a catheter, with the utmost regard to cleanli- ness and asepsis (so as to exclude the smegma bacillus). The urine thus obtained must be centrifuged for a long time. Some of the sediment is placed on a slide with a small quantity of egg albumin ; it is covered with some car- bolfuchsin, and allowed to steam over a small flame for about two minutes, care being taken that it does not boil. Wash it thoroughly in water and then decolorize by im- mersing it in a solution of any dilute mineral acid for about a minute. Then make a contrast stain with solution of Loeffier's methylene blue for about a minute; wash it again and examine with oil immersion lens. The tubercle bacilli will appear as thin, red rods, while all other bac- teria will appear blue. PATHOLOGY. i. See French's "Practice of Medicine" (1907), page 588; or Osier's "Practice of Medicine" (1909), page 802. 2. See French's "Practice of Medicine" (1907), pages 898 and 002; or Osier's "Practice of Medicine" (1909), pages 692 and 695. 3. "The iris is congested, swollen, and infiltrated with round cells. There is an exudate of round cells, fibrin, and pigment cells, which fills the anterior chamber and glues the edge of the pupil and back of the iris to the anterior capsule of the lens." — (Ailing and Griffin's Epito- me of the Eye and Ear.) 4. See French's "Practice of Medicine" (1907), page 254; or Osier's "Practice of Medicine" (1909), page 244. 5. See French's "Practice of Medicine" (1907), page 735; or Osier's "Practice of Medicine" (1909), page 460. THERAPEUTICS. 1. Opium. Official preparations, with doses: Powdered opium, gr. j ; extract of opium, gr. ss ; powder of ipecac and opium, gr. vijss; vinegar of opium, rp^viij ; camphorated tincture of opium, 5ij ; deodorated tincture of opium, Tl^viij ; granulated opium, gr. jss; wine of opium, n^viij ; morphine, gr. 1/5; morphine sulphate, acetate, and hydrochloride, each gr. % ; codeine, gr. y 2 ; codeine sul- phate and phosphate, each, gr. ]/ 2 ; apomorphine hydro- 362 MEDICAL RECORD. chloride, gr. i/io. Therapeutic uses: As an anodyne, in diarrhea, peritonitis, for internal hemorrhages, in mania and delirium tremens, in many respiratory affections, in diabetes, and to prevent or lessen shock. 2. Colckicum. Physiological action: It is a diuretic, causes irritation of the gastrointestinal tract, salivation, collapse, and increases the output of uric acid. Therapeutic uses: Chiefly used in gout; also in headache, dyspepsia, or neuralgia in gouty people. 3. Bryonia. Dose, gr. x to lx. It is used as a hydra- gogue cathartic, in cases of dropsy or other serous effu- sions. 4. Precipitated calcium phosphate, gr. xv; syrup of cal- cium lactophosphate, 5ij. It is used in diseased conditions of the bones, rickets, mollities ossium, scrofula, anemic conditions, tuberculosis. 5. Veratrum. Dose, gr. ij. Uses: As a circulatory de- pressant in pneumonia, in puerperal convulsions, tonsillitis, puerperal inflammations in general, mania, and as a rule very much as aconite. 6. Ipecac. Dose, gr. j as an expectorant; gr. xv as an emetic. Action: Hemostatic, expectorant, emetic, stom- achic, cholagogue, and diaphoretic. Uses: As an emetic, to clear the respiratory passages, to relieve the stomach, in bronchitis, emphysema, dysentery and jaundice, and as a diaphoretic in rheumatism. 7. Nux vomica. Officinal preparations: Extract, gr. %; fluid extract, TT#j ; and tincture of nux vomica, TTgx. Strych- nine (with its sulphate and nitrate), each gr. 1/64. Uses: As a general tonic or bitter; in indigestion, cardiac de- pression, impaired peristalsis, pneumonia, phthisis, amenor- rhea, dysmenorrhea, impotence, and urinary incontinence. 8. Tartar emetic. Dose, gr. 1/10 as an expectorant, and gr. y 2 as an emetic. Indications: In inflammatory af- fections of the respiratory tract, when the secretion of mucus is not free ; in pneumonia, bronchopneumonia, colds, bronchitis, laryngitis, and tonsillitis. 9. Aconite. Dose: Fluid extract, TTgj ; tincture, Tl^x. Medicinal uses: For fevers, some inflammatory conditions, in high arterial tension, in nervous palpitation of the heart, and congestive dysmenorrhea ; also externally for neural- gia, pruritus, herpes, chilblains, etc. 10. Cinchona. Officinal preparations: Fluid extract, TTBxv ; tincture, 3j ; compound tincture of cinchona, 3j. Quinine (with its sulphate, bisulphate, hydrobromide, hy- drochloride, and salicylate), each gr. iv; cinchonine sul- phate, gr. iv; cinchonidine sulphate, gr. iv. Uses: In malaria; as a tonic; in influenza, in dyspepsia, in asthma: as an antipyretic ; and locally, for sores in diphtheria, and in hay fever. 063 MEDICAL RECORD. PRACTICE. i. See French's "Practice of Medicine" (1907), page 298; or Osier's "Practice of Medicine" (1909), page 112. 2. Methods of physical diagnosis are : Inspection, palpa- tion, percussion, auscultation, mensuration, and weighing. Inspection shows the shape, size, symmetry, movements, and color of the chest. Palpation confirms and adds to what is learnt by inspection, shows areas of tenderness, condition of chest walls, presence of tumors, action of heart, and the existence and character of fremitus. Per- cussion shows the composition of structures or tissues, the resistance or elasticity or certain organs, and resonance of lungs. Auscultation enables one to study the condition of the heart and lungs. 3. See French's "Practice of Medicine" (1907), pages 151, 156, and 174; or Osier's "Practice of Medicine" (1909), pages 165, 172, and 189. 4. The early manifestations of pulmonary tuberculosis are: (1) Physical signs: Deficient chest expansion, the phthisical chest, slight dullness or impaired resonance over one apex, fine moist rales at end of inspiration, expiration prolonged or high pitched, breathing interrupted. (2) Symptoms: General weakness, lassitude, dyspnea on exer- tion, pallor, anorexia, loss of weight slight fever, and night sweats, hemoptysis. For treatment, see French's "Practice of Medicine" (1907), page 392; or Osier's "Practice of Medicine" (1909), page 352. 5. See French's "Practice of Medicine" (1907), pages 65 and 109; or Osier's "Practice of Medicine" (1909), pages 57 and 99. 6. See French's "Practice of Medicine" (1907), pages 649 and 650; or Osier's "Practice of Medicine" (1909), pages 602 and 603. 7. See French's "Practice of Medicine" (1907), pages 893 and 895; or Osier's "Practice of Medicine" (1909), j pages 688 and 690. ^ 8. A cataract is an opacity of the crystalline lens or its capsule. Treatment: Extraction of the lens by operation is the only means of relieving a patient of senile cataract; discission is applicable only to cataracts of the young. No medicinal treatment, whether local or constitutional, is of curative value. 9. See Rose and Carless' "Surgery" (1908), page 882. 10. Psoriasis "is a common chronic inflammatory disease of the skin, characterized by variously sized lesions, having red bases, covered with white scales resembling mother-of- pearl. It affects by preference the extensor surface of the body. The lesions are infiltrated, elevated, clearly defined, 364 MEDICAL RECORD. covered with white, shining, easily detachable scales which, upon removal, reveal a red, punctuate, bleeding surface. The eruption is absolutely dry, and itching is usually ab- sent. Treatment consists in the internal administration of arsenic, codliver oil, oil of copaiba, or potassium iodid, and the use of local applications. The scales should be removed by soap and water, alkaline baths, or oily sub- stances. Ointments containing salicylic acid (3 per cent, to 10 per cent), tar (3i to %i of ointment), ichthyol (3i to Ji), chrysarobin (gr. 10-60 to $1), ammoniated mercury (gr. 10-40 to 5 1 )* etc., are very beneficial, and should be used after the scales have been removed." — (Gould and Pyle's Pocket Cyclopedia.) OBSTETRICS. 1. See Williams' "Obstetrics" (1909), pages 94, 97, 144, and 254; or Hirst's "Obstetrics" (1909), pages 78, 83, and 396. 2. See Williams' "Obstetrics' (1909), page 809; or Hirst's "Obstetrics" (1909), page 572. 3. The hand is in a straight line with the forearm, the thumb is at right angles to the other fingers, and may be bent across the palm. The foot is at right angles to the leg, the great toe cannot be altered in its relation to the other toes, the malleoli and os calcis may be felt. The knee has two tuberosities with an intervening de- pression ; the patella may also be felt. The elbow has three prominences (the olecranon process of the ulna and the two condyles of the humerus). In shoulder cases (as distinguished from vertex) the tumor is unsymmetrical in shape, and is longer transversely or obliquely; the head can be felt in one iliac fossa, and the breech higher up in the flank of the opposite side. In cases of shoulder presentation, if seen before labor, version should be performed to correct the representa- tion ; in case of impaction a cesarean section is indicated ; sometimes decapitation or embryotomy has been performed, but a cesarean section is preferable. Cases of shoulder presentation have been known to terminate spontaneously, but it is not advisable to rely on this possibility. 4. _ Puerperal eclampsia is an acute morbid condition, oc- curring during pregnancy, labor, or the puerperal state, and is characterized by tonic and clonic convulsions, which af- fect first the voluntary and then the involuntary muscles; there is total loss of consciousness, which tends either to coma or to sleep, and the condition may terminate in re- covery or death. The causes may be : UVemia, albumin- uria^ imperfect elimination of carbon dioxide by the lungs, medicinal poisons, septic infection; predisposing causes are renal disease and imperfect elimination by the skin, bowels, 36s MEDICAL RECORD. and kidneys. Prognosis is serious to mother and child. Preventive treatment: (i) The amount of nitrogenous food should be diminished to a minimum; (2) the pro- duction and absorption of poisonous materials in the in- testines and body tissues should be limited and their elim- ination should be aided by improving the action of the bowels, the kidneys, the liver, the skin, and the lungs; (3) the source of the fetal metabolic products and the periph- eral irritation in the uterus should, if necessary, be re- moved by evacuating that organ. Curative treatment: (1) Control the convulsions (by chloroform, veratrum, or chloral); (2) eliminate the poison or poisons which are presumed to cause the convulsions; (3) empty the uterus under deep anesthesia, by some method that is rapid and that will cause as little injury to the woman as possible. 5. See Williams' "Obstetrics" (1909), pages 321, 324, 661, and 822; or Hirst's "Obstetrics" (1909), pages 331 and 587. 6. See Williams' "Obstetrics" (1909), page 397; or Hirst's "Obstetrics" (1909), page 809. 7. False labor pains are slight, occur before labor, do not cause dilatation of the os, do not produce a "show." True labor pains gradually increase in frequency and severity, occur during labor, cause the os to dilate, produce a "show." Labor is divided into three stages : The first stage be- gins with the commencement of labor, and ends with the complete dilatation of the os uteri. The second stage begins with a complete dilatation of the os uteri, and ends with the birth of the child. The third step immediately follows the second, and ends with the expulsion of the placenta and the beginning contraction of the uterus. 8. See Williams' "Obstetrics" (1009) page 844; or Hirst's "Obstetrics" (1909), page 939. 9. See Williams' "Obstetrics" (1909), page 347; or Hirst's "Obstetrics" (1909), pages 344 and 373. 10. See Williams' "Obstetrics" (1909), page 190; or Hirst's "Obstetrics" (1909), page 204. GYNECOLOGY. 1. See Rose and Carless' "Surgery" (1908), page 1277. Varieties of vulvitis: Catarrhal, follicular, venereal, diph- theritic, and phlegmonous. 2. See Rose and Carless' "Surgery" (1908), page 1277. Varieties of vaginitis: Acute, chronic, primary, secondary, catarrhal, membranous, diphtheritic, gonorrheal, granular, emphysematous, and senile. 3. Menstruation is a periodical disturbance in the female characterized by a bloody mucous discharge from the uterine cavity ; it lasts during the period of woman's sexual 366 MEDICAL RECORD. activity, but is temporarily suspended during pregnancy and early lactation. Disorders of menstruation include: (i) Premature or precocious menstruation; (2) protracted menstruation; (3) absence of menstruation (amenorrhea) ; (4) profuse men- struation (menorrhagia) ; (5) flow in between periods (metrorrhagia) ; (6) painful menstruation (dysmenor- rhea) ; (7) vicarious menstruation; (8) regular intermen- strual pain. Amenorrhea is physiological: Before puberty, during pregnancy and early lactation, and after the menopause. It may also be due to : Absence or imperfect development of the generative organs; also to stenosis, obstructions, or atresia of the genital tract ; also to operative removal of the uterus or its appendages, Other causative factors are : Acute infectious diseases, anemia, chlorosis, obesity, drug habits, alcoholism, overstudy, lack of exercise, exposure to cold, and various emotional causes. Treatment consists in: (1) Removing the cause, if possible; (2) general treat- ment by means of proper hygiene, rest, diet, bathing, atten- tion to the bowels, exercise, etc.; (3) drugs reputed to be emmenagogues, such as iron, manganese, aloes, strychnine, apiol, oxalic acid, savine, rue, and tansy. Common Causes of Menorrhagia. Constitutional: Pur- pura, scorbutus, hemophilia, hepatic cirrhosis, over indulg- ence in food and alcoholic drinks. Local and Vascular: Uterine congestion and displacement, endometritis, subin- volution, fibroids, and other tumors. Common Causes of Metrorrhagia. Constitutional: None. Local and Vascu- lar: Disease of uterus or appendages, polyps, extrauterine gestation, the hemorrhages in connection with pregnancy. Treatment of both : Remove the cause, if possible; treat abnormal conditions that are present; vaginal douches, tampons, and curettage have been recommended ; also ergot, hamamelis, hydrastis, and viburnum prunifolium; rest in bed is necessary. Intrauterine applications of astringents or of adrenalin have been used. Dysmenorrhea. Causes: Pelvic congestion, pelvic in- flammation, malnutrition, overwork, lack of development, neuralgia, stenosis or obstruction of the cervix, prolapse or displacement of the uterus. Treatment : < If possible, remove cause ; attend to the general condition, hygiene, tonics, regular habits, etc. ; curettage may be necessary, and may have io be repeated (perhaps more than once). 4. Metritis is inflammation of the body or parenchyma of the uterus. Varieties: Acute, chronic, hemorrhagic, catarrhal, suppurative, granular, ulcerative (and also ac- cording to etiology). Causes: Wounds, injuries, opera- tions, gonorrhea, septic -infection, puerperal sepsis, cold during menstruation, intrauterine medication, and manipu- 367 MEDICAL RECORD lations. Treatment : Remove the cause, if possible, pre- vention of sepsis, rest in bed, anodynes, hot vaginal douche, tampons with glycerin, iodin applications, suppository of opium and belladonna, dilatation, curettage, cauterization, irrigation, drainage, etc. 5. In the case of polypus, the body and fundus of the uterus are in their normal position in the abdbomen, a sound can be passed into the uterus, the uterine and cer- vical canals are not obliterated, the polypus does not bleed easily, and is not particularly sensible to pain. The in- verted uterus shows : Absence of body and fundus from normal position, will not permit passage of a sound into uterine cavity, the uterine and cervical canals are absent, the inverted uterus tends to bleed easily, and is very sen- sible to pain. In prolapse the largest part of the tumor is above; the opening of the Fallopian tubes cannot be seen; a sound can be passed into the uterine cavity. 1. SURGERY. TUMOR OF BRAIN. 1. No primary focus of in- fection but often history of syphilis or malignant dis- ease of other organs. 2. Very slow development. 3. More definite focal symptoms. 4. No rigors or septic symptoms. 5.. Temperature normal or slightly and irregularly ele- vated. 6. Pulse slow. 7. Constant headache. 8. Projectile vomiting fre- quently present. 9. General symptoms of pressure progressive. 10. Choked disc constant. ABSCESS OF BRAIN. i. Suppurating area in ear, nose, pharynx, scalp, or lung abscess. 2. More rapid. 3. Focal symptoms often present, but not so definitely localized as in tumor. 4. Often begins with chills, septic symptoms often con- tinue. 5. Temperature subnor- mal, other times higher — pus temperature. 6. Not slow as a rule. 7. Not a constant or prom- inent symptom. 8. Not often; vomiting, if present, more frequent and not projectile. 9. When present, they vary greatly in intensity. 10. Not constant. — (Eisendrath.) 2. See Rose and Carless' "Surgery" (1908), page 1088; or Da Costa's "Surgery" (1908), page 991. 3. See Rose and Carless' "Surgery" (1908), page 574; or Da Costa's "Surgery" (1908), page 442. 4. Gastric ulcer is generally caused by injury or bac- 36$ MEDICAL RECORD. J teria, is most apt to occur between the ages of twenty and forty-five; after eating there is pain localized in the stom- ach, vomiting occurs soon after eating, hematemesis is common, there is localized tenderness over the stomach, and examination of the gastric contents show an excess of free HC1. Gastric cancer does not usually occur before forty years of age, is more common in males, pain is localized and constant, vomiting is copious and occurs some time after eating; the vomitus contains ''coffee ground" material; hemorrhages are common ; a tumor may be palpated, and examination of the gastric contents shows absence of free HC1 and presence of lactic acid; severe anemia and ca- chexia are also present. 5. See Rose and Carless' "Surgery" (1908), page 243; or Da Costa's "Surgery" (1908), pages 572 and 258. 6. See Rose and Carless' "Surgery" (1908), page 1172; or Da Costa's "Surgery" (1908), page 1115. 7. Tuberculosis of the hip is characterized by: Mscular spasm, lameness, shortening, atrophy, and swelling. In congenital dislocation there is a history of limp since the child began to walk; the trochanter is above Nelaton's line; there is no muscular stiffness, and no limitation of motion at the hip joint. 8. See Rose and Carless' "Surgery" (1908), pages 507 and 513; or Da Costa's "Surgery" (1908), page 497. 9. See Rose and Carless' "Surgery" (1908), page 1121; or Da Costa's "Surgery" (1908), page 838. 10. See Rose and Carless' "Surgery" (1908), page 1229; or Da Costa's "Surgery" (1908), page 1190. HYGIENE. 1. Ophthalmia neonatorum. Etiology: It is due to the gonococcus or some other pyogenic germ ; and is pro- duced by contact of the eye with the vaginal secretion of the mother during labor, or infected fingers, or instru- ments, etc. Prophylaxis: Whenever there is the possibility of infec- tion, or in every case, wash the eyelids of the new-born child with clean warm water, and drop on the cornea of each eye one drop of a 1 or 2 per cent, solution of nitrate of silver, immediately after birth. 2. See French's "Practice of Medicine" (1907), pages 782, 783, and 781 ; or Osier's "Practice of Medicine" (1909), pages 507, 508, and 509. 3. Three infections through air: Tuberculosis, influenza, measles ; through water: typhoid, cholera, dysentery : through food: typhoid, tuberculosis, beriberi; through in- sects: Bubonic plague, malaria, yellow fever. For prophy- laxis see French's "Practice of Medicine" (1909) or Osier's 369 MEDICAL RECORD. "Practice of Medicine'' (1909), under name of the disease, in the index. 4. See French's "Practice of Medicine" (1907) or Osier's "Practice of Medicine" (1909), under name of the disease, in the index. 5. "The methods used^ in the production of antitoxins were introduced by Behring, who found that by injecting susceptible animals with increasing amounts of extracel- lular toxin he produced in the blood serum of the injected animal certain changes which made the serum capable of counteracting the same toxin when injected into other animals. ... In practice, the bacilli are cultivated in bouillon. The cultures are freed from all living bacilli by nitration. The liquid nitrate contains the toxin. This fil- trate is injected into healthy susceptible animals, in increas- ing doses. Usually the horse is used, since large quantities of blood can be drawn from this animal on account of its size, and, moreover, the horse is very susceptible. . . . Eventually enormous doses of toxin are given, and the animal acquires a high degree of immunity. The blood of the animal is withdrawn, taking care to avoid contamina- tion, and the serum allowed to separate in the refrigerator. The serum of the blood is drawn off and constitutes the antitoxin." — (Williams' Bacteriology. ) And see above, Bacteriology, i, 2, and 3 ; also French's "Practice of Medicine" (1907), article "Serum," in index. MEDICAL JURISPRUDENCE. 1. In cerebral concussion: There is sudden onset; pulse is slow and weak; respirations are shallow, slight, and ir- regular ; there is functional paralysis ; and incontinence of urine and feces. In intoxication there is gradual onset; full pulse ; respirations deep and slightly stertorous ; twitch- ing of muscles ; no incontinence ; the face is flushed, and the odor of alcohol may be on the breath. Note: The two conditions may be coincident. 2. A recent cerebral hemorrhage has a red color, the coagulum is not very firm. Later the color becomes brown- ish, the coagulum is firmer and more fibrous, and more ad- herent to brain and dura. 3. Malpractice is a failure on the part of a medical prac- titioner to use such skill, care, and judgment in the treat- ment of a patient as the law requires ; and thereby ^ the patient suffers damage. If due to negligence only, it is civil malpractice. But if done deliberately, or wrongfully, or if gross carelessness or neglect have been shown, or if some illegal operation (such as criminal abortion) be per- formed, it is criminal malpractice. 4. Drowning. Homicide: Rare, except in case of in- fants ; there are probably marks of violence on the body, 3?c MEDICAL RECORD. not due to post-mortem factors. Suicide: Very common, and when there were motives to suicide, or tendency to the same, suicide would be suspected; as a rule there would be no witnesses. Accident: Very common; often wit- nesses present; proximity of precipice or other dangerous place would suggest accident. It is often impossible to differentiate the three conditions. 5. Hanging : The presumption is in favor of suicide; but evidences of great external violence and marks of a struggle or signs of fingers about the throat would point to homicide; a position of the body (with hands and feet tied), in which the patient could not have put himself, would point to homicide. Accidental hanging is rare, and occurs chiefly among children, while playing. 6. Personal identity is based on : Deformities, tattoo marks, scars, general appearance, actions, voice, manner of speech, apparent age, figure, size, gait, dress, moles, birth-marks, professional stigmata, handwriting, finger im- pressions, foot prints, examination of hair, condition of the teeth, color of hair and eyes. STATE BOARD EXAMINATION QUESTIONS. Board of Medical Examiners of the State of Montana. ANATOMY. 1. Give the origin, insertion, and action of the following muscles : deltoid, latissimus dorsi, rectus femoris, and tibialis anticus. 2. Trace the arterial blood supply from the heart to the foot, naming the principal branches given off. 3. Give the origin, course, and distribution of the fol- lowing nerves : seventh cranial, great sciatic, median. 4. Give classification of joints, with an example of each. 5. Name and describe the salivary glands. P.HYSI0L0GY. 1. Give the varied functions of the sympathetic nervous system. 2. How is normal body temperature regulated and sus- tained? 3. What is metabolism? What are its objects? 4. Give the mechanism of respiration. How is it reg- ulated? 5. How is the heartbeat regulated and sustained? 6. Describe the digestion of a meal of beeksteak and potatoes. Answer five questions. MATERIA MEDIC A. i. What is the alkaloid of hyoscyamus? What is the dose 371 iMEDICAL RECORD. of hyoscyamus? What is the dose of hyoscine hydro- bromate for hypodermic use? 2. Give the average adult dose of the following: (i) liquor potassii arsenitis, (2) tinctura nucis vomicae, (3) tinctura opii, (4) spiritus glyceritis nitratis, (5) oleum tiglii, (6) eserina, (7) hydrargyri chloridum corrosivum. 3. Mention the conditions which affect the dosage of medicines. 4. What are incompatibles in medicine, and what are the different kinds of inqompatibles ? 5. Name four efficient hypnotics and give source and dose of each. THERAPEUTICS. 1. By what methods do antipyretics act? Give an ex- ample of one that acts by each method. 2. What are the physiological effects and medicinal uses of the preparations of belladonna? 3. State the condition of the venous system and that of the arterial system that indicate the use of digitalis, and what effect this drug has on the arterioles. 4. How do antagonists 'and antidotes differ? Illustrate. 5. Name three drugs used to accelerate the action of the heart, also three drugs used to retard its action, and state the dose of some preparation of each. PRACTICE. 1. Differentiate cardiac hypertrophy from cardiac dilata- tion ; organic from functional heart murmurs. 2. What are the causes and symptoms of dilatation of the stomach ? 3. Give the causes and symptoms of ascites, and tell how to recognize by what disease it is produced. 4. If summoned to a middle-aged person discovered in a comatose condition, explain how to recognize upon what disease the condition depends and give treatment for the uremic type of coma. 5. Differentiate catarrhal from croupous pneumonia and £ive treatment for the former disease. SURGERY. 1. Give symptoms, diagnosis, and treatment of strangu- lated inguinal hernia. 2. Give differential diagnosis between gallstone colic, appendicitis, and kidney colic. 3. Give symptoms, diagnosis, and treatment of acute empyema. 4. Give symptoms, diagnosis, and treatment of acute osteomyelitis. 5. Give symptoms, diagnosis, and treatment of fractures 372 MEDICAL RECORD. in general. Give differential diagnosis between fracture and dislocation. DISEASES OF WOMEN AND CHILDREN. i. Give the symptoms, diagnosis, and treatment of gonor- rheal cystitis. 2. What are the indications for a complete hysterectomy? 3. Give the symptoms, diagnosis, and treatment of laryn- geal diphtheria. 4. Differentiate scarlet fever, measles, and rotheln. 5. Give the varieties, symptoms, diagnosis, and treatment of stomatitis. OBSTETRICS. 1. Give the differential diagnosis of the different kinds of convulsions which may arise in the puerperal state. 2. Give diagnosis of a transverse presentation and its causes and management. 3. Give the causes and treatment of post-partum hemor- rhage. 4. Give the symptoms and treatment of an incomplete abortion. 5. Describe the third stage of labor and its management. DISEASES OF THE NERVOUS SYSTEM. i. Give the etiology, diagnosis, and treatment of chorea. 2. Differentiate neuritis from neuralgia. 3. What is aphasia? Describe its varieties. 4. Give the etiology, symptoms, and treatment of acute anterior poliomyelitis. 5. In what conditions is the patellar reflex increased, diminished, or absent? DISEASES OF THE EYE AND EAR. 1. Give the diagnosis and treatment of gonorrheal oph- thalmia. 2. Give the causes and sequelae of suppurative middle- ear disease. 3. Give the etiology, diagnosis, and treatment of tra- choma. 4. Give the symptoms and treatment of acute mastoiditis. 5. Give the diagnosis and treatment of corneal ulcer. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Board of Medical Examiners of the State of Montana. ANATOMY. I. Deltoid. Origin: From the outer third of anterior border and upper surface of the clavicle, from the outer 373 MEDICAL RECORD. margin and upper surface of the acromion process, and from the lower edge of the spine of the scapula. Insertion : Into the deltoid impression on the middle of the outer side of the shaft of the humerus. Action : It raises the arm from the side so as to bring it at right angles with the body ; its anterior fibers draw the arm forward ; its poste- rior fibers draw the arm backward. Latissimus dorsi. Origin : From the spinous processes of lower six dorsal vertebrae, posterior layer of lumbar fascia, external lip of crest of ilium, and from the three or four lowest ribs. Insertion : Into the bicipital groove of the humerus. Action : It depresses the humerus, draws it backward, adducts it, and rotates it inward. Rectus femoris. Origin : Two heads, one from the ante- rior inferior spine of the ilium; the other from groove above the brim of the acetabulum. Insertion : Inco the patella, in common with the Vasti and Crureus. Action : It flexes the hip and extends the knee. 2. From the heart the blood flows into the arch of the aorta, thoracic aorta, abdominal aorta, common iliac, ex- ternal iliac, femoral, popliteal, anterior tibial, and dorsal- is pedis arteries. Branches of the arch of the aorta: Innominate, left common carotid, and left subclavian. Of the thoracic aorta: Bronchial, esophageal, pericardial, mediastinal, and intercostals. Of the abdominal aorta : Phrenic, celiac axis, superior mesenteric, suprarenal, renal, spermatic (or ova- rian), inferior mesenteric, lumbar, and sacra media. Of the external iliac: Deep epigastric and deep circumflex iliac, Of the femoral : Superficial epigastric, superficial circum- flex iliac, superficial external pudic, deep external pudic, profunda femoris, muscular, and anastomotica magna. Of the popliteal: Muscular, cutaneous, superior articulars, in- ferior articulars, and azygos. Of the anterior tibial: An- terior and posterior recurrents, internal and external mal- leolar, and muscular. 3. See Cunningham's "Anatomy" (1909), pages 686, 648, and 627; or Gray's "Anatomy" (1908), pages 1059, 1030, and 1004. 4. Classification of Joints, i. Diarthrodial, or freely movable; as hip and knee. 2. Amphiar thro dial, or slightly movable; as symphysis pubis and joints between bodies of vertebrae. 3. Synar thro dial, or immovable ; as ethmoid with vomer and parietal with frontal. 5. See Cunningham's "Anatomy" (1909), page 1009; or Gray's "Anatomy" (1908), page 1224. physiology. * 1. Functions of the sympathetic nervous system: "It may safely be said that the sympathetic system has, to a 374 MEDICAL RECORD. great extent, a controlling influence over the secretion of most of the glands, the lacrymal, the salivary, the sweat glands, the glands of the stomach and intestines, the liver, the kidney, etc. ; that it presides over the circulation by regulating the caliber of the blood-vessels and the action of the heart; that it influences respiration; and, finally, that all involuntary muscles, those of the digestive apparatus, of the genitourinary system, of the hair follicles (pilomo- tor nerves), are under its control to such extent that, for instance, in certain mammalians the bladder still continues to fulfill its function for weeks after all the cerebrospinal motor nerves leading to it have been severed. In short. we find that all vegetative life of the organism is, to a greater or less extent, under the control of the sympathetic system. Therefore it may properly be called the vegetative nerve system par excellence" — {Reference Handbook of the Medical Sciences.) 2. The normal body temperature is regulated and main- tained by the thermotactic centers in the brain and cord keeping an equilibrium between the heat gained or pro- duced in the body and the heat lost. Heat is produced in the body by: (i) Muscular action; (2) the action of the glands, chiefly of the liver; (3) the food and drink ingested; (4) the brain; (5) the heart; and (6) the thermogenetic centers in the brain, pons, medulla, and spinal cord. Heat is given off from the body, by: (1) The skin, through evaporation, radiation, and conduction ; (2) the expired air; (3) the excretions — urine and feces. 3. Metabolism is a name given to the entire series of changes that occur in a cell or organism during the proc- esses of nutrition. It is of two kinds: (1) Anabolic or constructive, and (2) catabolic, or destructive. The objects of metabolism, are: Nutrition and life, and the conservation of bodily energy. 4. Mechanism: This consists of inspiration and expira- tion ; the former is a muscular act brought about by en- largement of the capacity of the thorax. And see Gray's ^Anatomy" (1908), pages 289 and 433; or Cunningham's "Anatomy" (1909), pages 415 and 419. Regulation is by the respiratory center and afferent and efferent nerves. "The respiratory center is in reality made up of two cen- ters, one for each side, so that, although anatomical 1 y con- nected and ordinarily acting together, yet if one center is broken up. while the respiratory movements on that side cease, those on the other side continue. Besides this double character of the center, each half is made up of an inspiratory and an expiratory center. The respiratory center is both an automatic and a reflex center — i.e. it sends out spontaneously impulses which result in move- 37S MEDICAL RECORD. ments of the respiratory muscles, constituting its auto- matism; and it may also be excited reflexly — i.e. by im- pulses reaching it from without. Its reflex character is most marked, and it is doubtless as a reflex center that its function is ordinarily performed." — {Raymond.) 5. The heart beat is influenced by (1) intrinsic cardiac ganglia, (2) the vagus (which slows it), and (3) the sym- phathetic (which accelerates it) ; these latter are under the control of two centers in the medulla, the cardio-inhibitory and the cardio-accelerator. 6. The proteids are digested in the stomach and small intestine, where the pepsin of the gastric iuice and the trypsin of the pancreatic juice convert them into proteoses and peptones. The fat is digested in the small intestine, where the steapsin of the pancreatic juice emulsifies and saponifies it (and the bile also helps). The carbohydrate is digested in the mouth and small intestine, where the ptyalin of the saliva and the amylopsin of the pancreatic juice con- vert it into maltose. MATERIA MEDICA. i. The alkaloid of hyoscyamus is hyoscyamine. The dose of hyoscyamus is gr. vij. The dose of hyoscine hydrobromide for hypodermic use is gr. 1/150. 2. Average adult dose of: (1) Liquor potassii arsenitis, is Tl#iij ; (2) tinctura nucis vomicae, is Tl#x; (3) tinctura opii, is Tl^viij ; (4) spiritus glycerylis nitratis, is TT#j ; (5) oleum tiglii, is nj?j ; (6) eserina (sulphate or salicylate), is gr. 1/64; (7) hydrargyri chloridum corrosivum, is gr. 1/20. 3. The conditions which affect the dosage of medicines, are : Age, body weight, body temperature, drug habits, idiosyncrasy, method of administration, intervals between doses, cumulative action of drug, disease, and race. 4. Incompatibles are substances which, when combined or associated, undergo a more or less complete change. The different kinds of incompatibles are : Chemical, phar- maceutical, and therapeutic. 5- FOUR EFFICIENT SOURCE. DOSE. HYPNOTICS. Chloral hydrate. Alcohol and chlo- rine. gr. xv to xx. Sulphonal. Acetone and mer- captan. gr. xv to xxv. Trional. Methylethylketone and mercaptan. gr. xv to xxv. Paraldehyde. Acetic aldehyde and sulphuric acid. TTj^xxx to 3j. 376 MEDICAL RECORD. (b) Promoting heat loss, by THERAPEUTICS. i. The following table (from Potter's Materia Medico) gives the chief temperature depressants, with their man- ner of action : Temperature depression may be done by five different actions working upon two principal lines, viz., by — "(i) diminishing tissue (a) Lessening heat production, by -j (2) ^j^jg the dr _ culation. (3) dilating cutaneous ves- sels, thus increasing heat radiation. (4) promoting perspiration — its evaporation low- ering the temperature. (5) abstracting heat from the body. The following list of antipyretics includes a few for each of the above named actions, to which the numbers refer in each case, viz. : Quinine, 1. Aconite, 2. Alcohol, 1, 3, Phenol, 1. Nitrous ether, 3, 4. Antimony, 2, 4. Salicin, 1. Acetanilid, 1, 4. Cold bath, 5. Digitalis, 2. Phenacetin, 1, 4. Cold drinks, 5. Antipyrin, 1, 4. Wet pack, 5. 2. Belladonna and Its Preparations. Physiological effects : Anodyne, mydriatic, inhibits secretions, depres- sant of terminations of nerves, accelerates the heart beat, causes rise in blood pressure, but toxic doses cause the blood pressure to fall, stimulates the respiratory center, but large doses depress the same; it may cause vertigo, restlessness, excitement, delirium, or mania. Medicinal uses : To relieve pain, relax spasm, check sweating, as a mydriatic, for night sweats, to check griping of purgatives ; in asthma, to check fevers, in heart dis- ease, shock and collapse, acute coryza, urinary incontinence, chordee, low delirium of fevers, mania, alcoholism; as an antigalactagogue, spasmodic cough. 3. Digitalis is indicated when there is low arterial ten- sion and rapid pulse. Being a vaso-constrictor, it will contract the arterioles. 4. Antagonists "are agents which directly oppose each other in some or all of their physiological actions, and therefore may be used, one against the other, in a case of poisoning by either, to counteract its effect upon the organ- ism, after it has been absorbed, and when, therefore, the 377 MEDICAL RECORD. time for an antidote has passed. Antagonistic action takes place in the blood and tissues, and is applicable almost en- tirely to vegetable poisons." Antidotes "are agents which act upon poisons in such a manner as to alter their composition, rendering them more or less innocuous and so preventing their toxic action being exerted upon the organism. Antidotal action takes place in the alimentary canal, upon such portion of the poison as is unabsorbed, and is applicable to vegetable as well as to mineral poisons." — (Potter's Materia Medica.) 5. Three drugs used to accelerate the action of the heart : (1) Ammonia; dose of aromatic spirits of ammonia, TT#xxx. (2) Camphor ; dose of spirit of camphor, TfRxv. (3) Alcohol; dose of brandy, Jj. Three drugs used to retard the action of the heart: (1) Aconite; dose of tincture of aconite, TTRviij. (2) Digitalis; dose of tincture of digitalis, TTgxv. (3) Veratrum ; dose of tincture of veratrum, ITgxv. PRACTICE. 1. Cardiac hypertrophy is usually a conservative process; there is an increase in the muscular tissue of the heart; the cardiac area is enlarged ; the precordium bulges ; the heart beat is slow and strong; the pulse strong and regular: the cardiac enlargement is chiefly downward and outward; the first sound is long, loud, and booming, and the second sound is accentuated. Cardiac dilatation is generally a destructive process; the cavities of the heart are enlarged ; the cardiac area is en- larged; the heart beat is weak and diffuse; the pulse is weak and irregular and rapid; the cardiac enlargement is outward and upward, and gives the heart a quadrangular outline ; the first sound is short and weak ; the second sound is also weak ; there may be soft, systolic murmurs, and there are generally signs of venous engorgement. Organic murmurs are due to stenosis or incompetency of one or more of the valves of the heart. Functional murmurs are not due to valvular disease. Organic murmurs may be systolic or diastolic; may be accompanied by marked dilatation or hypertrophy, and there will probably be a history of rheumatism or of some other disease capable of producing endocarditis. Whereas a murmur, usually systolic, soft, and blowing, heard best over the pulmonic area, associated with evidences of chlo- rosis or anemia, and affected by the position of the patient, is a hemic or functional murmur, and denotes as a rule an impoverished condition of the blood. 2. Dilatation of the Stomach. Causes: Motor insuffi- ciency of the stomach wall ; obstruction of the pylorus by 378 MEDICAL RECORD. cancer, or cicatrix from ulcer; pressure on duodenum from without by tumors or adhesions ; pyloric hypertrophy. Symptoms : Dyspepsia; emaciation; thirst; constipation; pain,, and vomiting at long intervals of large quantities of sour and fermenting fluid, which contains particles of food taken several days previously; yeast cells and sarcinae may be present in the vomitus. The outline of the stomach may be seen to be enlarged ; percussion and auscultation show enlargement also, and artificial inflation of the stomach may also show increased stomach area. 3. Ascites is caused by : Mechanical obstruction of the portal circulation ; cardiac or pulmonary diseases obstruct- ing the general venous circulation; disease of the peri- toneum ; diseases of the kidneys ; anemia, debility, ex- posure to cold or wet; cancer, syphilis. Symptoms : Generally of gradual onset; abdominal dis- tention, sense of weight and fullness; dyspnea; gastro- intestinal disturbances ; lineas aibicantes, presence of fluid may be detected by palpation, percussion, or aspiration. If due to heart or lung disease, ascites will occur elsewhere, and the legs are generally affected first; in hepatic dis- orders the abdominal distention is marked, and appears early; in renal disease, the abdominal fluid is generally small in amount. 4. In alcoholic coma the coma is not usually absolute; there may be an odor of alcohol on the breath, the patient can generally be aroused by shouting in his ear ; there is no paralysis; the pupils are normal or dilated; respiration is practically normal; the pulse is first rapid and later feeble, and the skin cool. In uremic coma the coma is deep; there may be a uri- nous odor to the breath ; the urine is scanty and contains albumin ; there is slow pulse, with high arterial tension ; the pupils are usually small and equal ; respiration is deep and may be quickened; the body temperature may be above normal or subnormal. In cerebral apoplexy there is generally paralysis of the head and upper limbs, and in left-sided lesions there may be aphasia ; the pulse is slow and full ; the respirations are at first slow, regular, and stertorous, later on becoming of the Cheyne-Stokes type. In opium poisoning the pupils are contracted, there is no sign of paralysis ; both respirations and pulse are slow and full. In coma of epilepsy: History of attack, with previous convulsion ; the coma is of brief duration, and the uncon- sciousness gradually becomes less ; there may be a bitten tongue or other scars. 379 MEDICAL RECORD. 5- CROUPOUS PNEUMONIA. Generally a primary disase. Age has little influence. Sudden onset. Fever is high and regular. Ends by crisis between sixth and tenth day. Generally only one lung af- fected. The physical signs are dis- tinct, and there is a large area of consolidation. Sputum is rusty. CATARRHAL PNEUMONIA. Generally secondary (to bronchitis or an infectious disease). Generally found in very young or very old. Gradual onset. Fever is not so high, and is irregular. Ends by lysis, at no partic- ular date. Generally both lungs af- fected. Physical signs indistinct, and the evidences of consoli- dation are indefinite. Sputum is rather streaked with blood. SURGERY. i. Rose and Carless' "Surgery" (1908), pages 1099 and 1103; or Da Costa's "Surgery" (1908), page 994. 2. In gallstone colic : The pain is in the region of the liver; it radiates to the right scapula and toward the um- bilicus; chills and sweats are common; also vomiting, and sometimes symptoms of collapse and jaundice; calculi are found, if at all, in the feces. In appendicitis : The pain is at first diffuse, but later becomes localized over the appendix in the right iliac fossa; nausea, vomiting, and constipation may be present; tenderness over the appendix and rigidity of the right rectus abdominis muscle are present ; there is generally moderate fever. In kidney colic : The pain is in the region of the affected kidney; it radiates down the thigh; there are intense rigors; retraction of the testicle may be present; also his- tory of previous attacks or of calculi; the urine may be scanty, suppressed, or bloody. 3. Acute Empyema. Symptoms : Fever, sweats, chill, diminished breath sounds and vocal fremitus, impaired mobility of chest, dullness on affected side, heart displaced to opposite side, leucocytosis. Diagnosis is made by aspiration, showing the fluid to be pus. Treatment: Aspiration, drainage, irrigation, resection of ribs (Estlander's operation) or resection of chest wall (Schede's operation). 380 MEDICAL RECORD. 4. Osteomyelitis is inflammation of the bone and mar- row ; the term is often used now for inflammation of bone. It is caused by infection, the bacteria gaining entrance either through a wound, or by extension from neighboring tissues, or they may be brought by the blood. Symptoms: Sudden onset; pain, tenderness, fever, chills, swelling of soft parts; sometimes the joint can be moved gently without pain ; septicemia or pyemia may be present. It is to be diagnosed from (1) Rheumatism, in which more than one joint is affected and the tenderness is in the joint, and not near it. (2) Tubercular arthritis, in which the onset is slow and the trouble starts in the epiphysis rather than in the diaphysis. (3) Cellulitis in which the bone and periosteum are not affected, and in which there is always a wound. In osteomyelitis, the treatment consists in relieving the constitutional symptoms and preventing the bone from necrosing. An incision down to the bone is made; if pus is beneath the periosteum, the latter is also incised; a piece of bone is removed by chisel or trephine, pus is removed, the endosteum is hurt as little as possible, the wound is irrigated with hot bichloride solution and packed with gauze; the soft parts are closed and the wound well drained. In case this fails, amputation may be necessary. 5. The general symptoms of fracture are : History of injury, disability, pain, swelling, deformity, abnormal mo- bility, and crepitus. The cardinal principles in the treatment of fractures are : Reduction, coaptation, immobilization, and suitable meas- ures for promoting the nutrition of the part and for pre- venting adhesions in the neighboring joints and muscles. Compound fractures, in addition, demand: Asepis, re- moval of foreign matter or damaged tissues, stopping the hemorrhage, and measures to combat shock. FRACTURE. 1. Crepitus may be present. 2. Preternatural mobility. 3. Easily reduced — but 4. Deformity more liable to recur after reduction. 5. The head of the bone is in its proper place. 6. The socket containing the head of the bone is not empty. 7. When rotated the bone does not move as one piece. DISLOCATION. i. Crepitus never present. 2. Rigidity rather than mo- bility. 3. Difficult to reduce — but 4. Deformity less liable to recur after reduction.^ 5. The head of the bone is not in its proper place. 6. The socket which should contain the head of the bone is empty. 7. When rotated the bone moves as one piece. 38: MEDICAL RECORD. DISEASES OF WOMEN AND CHILDREN. 1. Gonorrheal Cystitis. Symptoms: Frequent mictu- rition; pain; bladder irritability and tenesmus; the urine is turbid and may contain blood, pus, or mucus ; the gono- coccus is present; the patient may also experience chills and fever. Treatment includes : Rest in bed ; administration of plenty of cold water or milk, diuretics, bland and mild foods, laxatives, hot sitz baths or vaginal douches, irriga- tion of the bladder with antiseptic solution, followed by solution of nitrate of silver. 2. The indications for hysterectomy are given as fol- lows : For the abdominal operation : All solid or cystic tumors of the uterus ; cancer ; uterine rupture during labor ; certain conditions of puerperal sepsis; pregnancy compli- cated by pelvic deformity, cancer, or other serious obstacle to the passage of the child; uterine prolapse or inversion, and incidentally as a step in the removal of complicated suppurative conditions of the uterine appendages. For the vaginal operation: Bilateral suppurative condi- tions of the appendages; prolapse, cancer, pregnancy with cancer before the sixth month ; certain septic conditions of the uterus ; certain rare conditions which may require the ablation of a small movable uterus. For the combined operation : Cancer, certain compli- cated fibroids ; failure to secure hemostasis from below. — (From Reference Handbook of the Medical Sciences.) 3. Laryngeal Diphtheria. Symptoms : General malaise, chills, fever, sore throat, stiff neck, congestion of soft pal- ate, whitish patches of membrane are formed. The fever may become very high ; the membrane is adherent ; re- forms if stripped off, and contains the Klebs-Loeffler bacillus. Cough and dyspnea are present. Diagnosis consists in a microscopical examination of the exudate, when the specific (Klebs-LoefBer) bacillus will be found. Treatment : The patient should be isolated and put to bed ; the atmosphere of the room should be kept moist ; the diet must be nutritious and easily digested; diphtheria antitoxin should be administered as soon as possible ; alco- hol or strychnine are indicated ; local applications, either hot or cold, will relieve the pain ; mild antiseptic solutions are often used. 382 CO >> •d p CU CU p > co £^ Ih s s fe m cj a >> >% . 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Therapeutic indications for use of chloral: As a hypnotic (in absence of pain), dose gr. xx; as an antiseptic, in a 1 per cent, solution ; in cases of acute mania or de- lirium tremens, dose gr. xx to xxx; in nervous dyspepsia, dose gr. xv; in fevers with high temperature, excitement, restlessness, etc., dose gr. xv; in seasickness, dose gr. v; in tedious labor, to relax a rigid os, and for uterine in- ertia, dose gr. xx; for nocturnal epilepsy, dose gr. xv; for infantile convulsions, chorea, whooping cough, and laryn- gysmus stridulus, dose according to age of child, taking adult dose as gr. xv to xx; in tetanus and strychnine poisoning it is said to be antagonistic, dose gr. xx; as an antipruritic, in a solution ten grains of chloral to one ounce of water. 5. To determine the proper dosage for a child: Let x x z= the age of a patient; then = the fraction of x + 12 the adult dose which the patient should receive. Thus, a 4 4 1 patient of four years old should receive = — = — 4+12 16 4 of an adult dose. 6. For acute bronchitis in an adult: Recipe : Ammonii chloridi, grana triginta. Tincturse opii camphoratse. Syrupi ipecacuanhas, ana drachmas tres. Syrupi pruni virginianse, unciam. Syrupi Tolutani, quantum sufficiat ad uncias quattuor. Misce et Signa : Take one teaspoonful every three hours. The "Case" with questions 7 to 10 is taken from Cabot's Case-teaching in Medicine; the answers are taken from the same source. 7. Gallstones and their results, cancer obstructing the biliary passages, syphilis of the liver, cirrhosis, septicemia (toxic jaundice). 8. Passive congestion, biliary obstruction from any cause, fat, cirrhosis, cancer, rickets; rarer causes are abscess, leukemia, pseudo-leukemia, cholangitis, amyloid, and hydatid disease. 9. None in this case. 10. Diagnosis: Gastric symptoms, nodular hepatic en- largement with severe pain, with emaciation and jaundice, and without evidence of portal stasis (ascites, etc.), point strongly to cancer of the liver, probably secondary to gastric cancer. The history of alcoholism and the hepatic 426 MEDICAL RECORD enlargement suggest cirrhosis, but there is rarely, if ever, so much pain in cirrhosis (or, indeed, in any liver disease except cancer), and the "hobnails" of cirrhosis are not large enough to make the liver feel "irregular and nodu- lar" through the abdominal wall. The absence of ascites is also against cirrhosis. Syphilis of the liver might produce all the signs described, and can only be finally eliminated by the therapeutic test, but the amount of pain here present is almost unknown in syphilis, and the amount of hepatic enlargement is very unusual. Prognosis: Hepatic cancer usually kills within a year of the discovery of its presence. Treatment : The relief of symptoms as they arise is all that can be hoped for if the diagnosis is correct, but in all cases of hepatic cancer KI should be given in doses of ten to thirty grains daily until it is proved to be valueless. A patient has been known to die of hepatic syphilis untreated, because her physician was sure it was cancer and had given up hope. The same is true of cirrhosis. All cases should be given KI and the benefit of the doubt whether our diagnosis is correct. The itching which may torture the patient in such cases should be treated by alkaline baths or washes, dilute carbolic washes, or vaseline. SURGERY. i. See Rose and Carless' "Surgery" (1908), pages 620 to 623; or, Da Costa's "Surgery" (1908), pages 587 to 592. 2. See Rose and Carless' "Surgery" (1908), page 481; or, Da Costa's "Surgery" (1908), page 464. 3. See Rose and Carless' "Surgery" (1908), page 308; or, Da Costa's "Surgery" (1908), page 356. 4. Causes of hematuria: "(1) Renal hematuria is due to acute nephritis, calculus, tumors, or injury of the kid- neys. Blood casts may be found. (2} Vesical hematuria is due to calculus, tumors, injury, cystitis, or the presence of the Bilhnrzia hcematobia. In the last the ova cause papillomatous tumors in the bladder. (3) Prostatic hema- turia is due to congestion, calculus, ulceration, or malig- nant disease. (4) Urethral hematuria is due to catheter- ism, laceration, or gonorrhea. The blood flows independ- ently of micturition. (5) Constitutional causes are pur- pura, scurvy, hemophilia. Hemoglobin is present, but not corpuscles, in paroxysmal hemoglobinuria. The spectrum and hemin tests are the most certain, but the guaiacum- ozonic ether test is reliable Tor urine." (From Aids to Surgery.) For treatment, see Rose and Carless' "Surgery" (1908)"; or, Da Costa's "Surgery" (1908), in the Index, under the various conditions mentioned above, under Causes. 427 MEDICAL RECORD 5. See Rose and Carless' "Surgery" (1908), page 914; or, Da Costa's ''Surgery" (1908), page 769. 6. See Rose and Carless' ''Surgery" (1908), page 926; or, Da Costa's "Surgery" (1908), page 773. 7. See Rose and Carless' "Surgery" (1908), pages 549 to 553; or, Da Costa's "Surgery" (1908), pages 532 to 53& 8. See Rose and Carless' "surgery" (1908), page 745; or, Da Costa's ''Surgery" (1908), page 709. 9. See Rose and Carless' "Surgery" (1908), page 1081 ; or, Da Costa's "Surgery" (1908), page 978. 10. See Rose and Carless' "Surgery" (1908), page 1134; or, Da Costa's "Surgery" (1908), page 1009. OBSTETRICS. 1. Irrigation after confinement is done: (1) By some practitioners, as routine treatment after every labor; (2) by others only when there have been repeated vaginal ex- aminations, or (3) in case of foul lochia; (4) or after some operative procedure; (5) in case of sepsis. Intra- uterine douche is indicated when the hand or instruments have been introduced into the uterus, or when sepsis is suspected. The solutions for vaginal douche may be : Hot 1 per cent, creolin mixture in boiled water; or bichloride of mercury, 1 :ioooo to 1:5000; or decinormal salt solution. For intrauterine douche: Plain sterile water, decinormal salt solution, creolin 1-2 per cent., a bichloride of mercury 1.10000, followed by plain sterile water. 2. Fibroids and polypi. 3. See Hirst's "Obstetrics" (1909), page 251. 4. The indications for version are: (1) In tranverse presentations; (2) in placenta prsevia ; (3) in malpresenta- tions of the head ; (4) in simple flattened pelvis, and in minor degrees of pelvic contraction; (5) in prolapsed funis; (6) in sudden death of the mother, and (7) in any case where speedy delivery is imperative. 5. See Williams' "Obstetrics" (1909), page 321; or, Hirst's "Obstetrics" (1909), page 329. 6. The most common causes of sterility in women are: Gonorrhea, absence or errors in development of any part ot the genital tract, malformations of genitals, fistulse, lacerations, obesity, alcoholism, pelvic inflammations, dys- pareunia, inflammations of uterus, tubes, or ovaries, elon- gated cervix. Treatment consists in removing the cause, if possible ; curettage has been recommended ; in the pres- ence of developmental errors little or nothing can be done ; atresia of cervix can ^e treated by dilatation; if the uterus is misplaced it must be replaced. 7. Treatment of eclampsia consists in: (1) Controlling the convulsions (by chloroform, veratrum, or chloral) ; (2) elimination of the poison or poisons which are pre- 428 MEDICAL RECORD sumed to cause the convulsions; (3) emptying the uterus under deen anesthesia, by some method that is rapid and that will cause as little injury to the woman as possible. 8. "When extrauterine pregnancy exists there are: (1) The general and reflex symptoms of pregnancy; they have often come on after an uncertain period of sterility; nausea and vomiting appear aggravated. (2) Then comes a disordered menstruation, especially metrorrhagia, accom- panied with gushes of blood, and with pelvic pain coinci- dent with the above symptoms of pregnancy; pains are often very severe, with marked tenderness within the pelvis; such symptoms are highly suggestive. (3) There is the presence of a pelvic tumor characterized as a tense cyst, sensitive to the touch, actively pulsating ; this tumor has a steady and progressive growth. In the first two months it has the size of a pigeon's egg ; in the third month it has the size of a hen's ^gg; in the fourth month it has the size of two fists. (4) The os uteri is patulous : the uterus is displaced, but is slightly enlarged and empty. (5) Symptoms Xo. 2 may be absent until the end of the third month, when suddenly they become severe, with spasmodic pains, followed by the general symptoms of collapse. (6) Expulsion of the decidua in part or whole. Xos. 1 and 2 are presumptive signs: Xos. 3 and 4 are probable signs; Nos. 5 and 6 are positive signs." [Ameri- can Text-Book of Obstetrics.) Treatment consists in the removal of the product of con- ception -by a laparotomy, as soon as the diagnosis is made. 9. See Williams 1 "Obstetrics" (1909). pages 914 and -~ or. Hirst's "Obstetrics'* (1909), pages 709 and 929. 10. See Williams' "Obstetrics" (1909). pages 480 to 623; or. Hirst's "Obstetrics" (1909). pages 215 and 284. STATE BOARD EXAMINATION QUESTIONS. State Board of Medical Examiners of New Jersey. ax atomy. Answer any ten questions, but no more. 1. What change takes place in the vascular system at birth: 2. Describe the structure of the arteries and give their nerve and blood supply. 3. How are the saphenous veins formed and where do they empty ? 4. Give blood and nerve supply of the tonsils. 5. Describe the renal blood circulation. 6. Describe the sphincter ani evternus. 7. How may the fissures of the Sylvius and Rolando be 429 MEDICAL RECORD. approximately mapped out on the surface of the skull? 8. What would be the collateral circulation if the brachial artery were ligated below its profunda branches? 9. Describe the dura mater, and mention the processes and sinuses of it. 10. What nerves form the pharyngeal plexus? 11. Give origin, course, and distribution of the nerves of the palm of the hand. 12. Mention a muscle which moves (a) the thumb out- ward, (b) the head forward, (c) the foot inward. 13. Give origin, insertion, blood and nerve supply, and action of any one of the following muscles : Gracilis, pec- toralis major, semimembranosus. 14. Give a general idea of the internal structure of the cerebrum. 15. Outline on the chest wall (a) the lungs, (b) the vena cava superior, (c) the arch of the aorta, (d) the left pulmonary artery. PHYSIOLOGY. Answer any ten questions in this paper, but no more. 1. Name the uses of the bile. 2. Name the circulating fluids of the body, and state the functions of each. 3. Define tidal and residual air, and state their normal quantity. 4. Define hemoglobin; state its functions and where it is found. 5. What effect does diet have upon the secretion and quantity of milk? 6. State the functions of the thyroid body and the effects of its removal. 7. Why does blood coagulate? Does lymph coagulate, and, if so, why? What chemical change is essential in either case? 8. Where is the respiratory center? What nerves are given off from it? What does each do? 9. State in order of importance the tissues in which animal heat is generated and by which it is given off. 10. Which of the following are secretions and which are excretions? Aqueous humor, tears, bile, cerebrospinal fluid, urine, perspiration, prostatic fluid. 11. State the immediate and remote effect of cutting the sciatic nerve. 12. State the causes of bodily fatigue. 13. What is a superficial reflex? What is a deep reflex? Name four examples of each. 14. Why does heat prostration occur more readily in a humid atmosphere than in a dry one? 15. State functions of the anterior and posterior spinal nerves. How many pairs are there? 430 -_- - . MEDICAL RECORD MATERIA MEDICA AND THERAPEUTICS. Answer any ten questions, but no more. i. Name (a) the officinal preparations of aconite, (b) adult dose of each, (c) medicinal uses, and (d) therapeu- tic effects. 2. State (a) the indications for the use of strychnine, (b) dosage for adults, and (c) symptoms and treatment of poisoning. 3. What purgatives act (a) on the small intestines, (b) on the large intestines, and (c) dosage of each? 4. (a) Enumerate the arsenical preparations used in medicine; (b) state their therapeutic properties with adult dose cf each. 5. Write a prescription based upon a diagnosis of acute ptomain poisoning. 6. (a) Explain the difference between galvanic and faradic current; (b) mention the classes of cases for the employment of each. 7. Specify the effect on the arterial system of (a) nitro- glycerin, (b) aconite, (c) digitalis, (d) veratrum viride, and (e) strophanthus. 8. Describe (a) the Widal serum test and (b) state its value and purpose in diagnosis. 9. Compare (a) the physiological action and (b) the dosage of podophyllin, cascara sagrada, and aloin. 10. Discuss the therapeutic uses and effects of (a) acet- anilid, (b) heroin, and (c) terebene; give dosage of each. 11. Specify (a) the method and (b) the effects of ad- ministering oxygen in pneumonia. 12. Differentiate the symptoms of poisoning by mor- phine, carbolic acid, and arsenic. 13. Give (a) the source, (b) therapeutic effect, and (c) dosage of pilocarpine. 14. Mention (a) three vegetable and (b) three mineral astringents with therapeutic employment and adult dose of each. 15. Discuss calomel in respect to (a) source, (b) effects, (c) dosage, and (d) incompatibilities. CHEMISTRY. Answer any ten questions, but no more. 1. Give the composition and properties of urea. 2. Mention the chemical reason for using lithia and its salts in cases of uric-acid diathesis. 3. What is the normal composition of urinary calculi? 4. Define fermentation, putrefaction, decay. 5. Mention the chemical name for white arsenic, proper- ties and uses. 6. Explain the atomic theory. 7. What is the chemical composition of bone? 431 MEDICAL RECORD 8. Name the principal pigment of normal urine. 9. What may very high or very low specific gravity of urine indicate? 10. Give the chemistry of respiration, showing what is inhaled, what is exhaled, and how the gases enter and leave the blood. 11. Define specific gravity. 12. What are the properties of bile? Give the chief con- stituent. 13. Explain the meaning of the terms reaction and re- agent. 14. Give Marsh's test. 15. What is the difference between vegetable and animal life from the chemical standpoint. HISTOLOGY, BACTERIOLOGY, AND PATHOLOGY. Answer only ten questions, and not less than three on each branch. Histology. 1. Name the varieties of muscle, and what are the differ- ences between them? 2. Describe the general characteristics of epithelium. 3. Describe non-medullated nerve-fibers and tell where they occur. 4. How do veins differ from arteries? Bacteriology. 5. State briefly a method of obtaining a pure culture. 6. Describe a process by which bacteria multiply. 7. Give Koch's rules in regard to the bacterial cause of disease. 8. Why does the air contain more bacteria in Summer than the air in Winter? 9. Differentiate between the bacillus coli communis and the bacillus of typhoid fever. 10. Define immunity; susceptibility. Pathology. 11. Describe the lesions of the kidney cortex in acute diffuse nephritis. 12. Describe the microscopic appearances of the tissues affected in tuberculosis pleuritis. 13. What are the lesions in infantile scurvy? 14. Give the pathology of .chronic interstitial hepatitis. 15. Give the pathology of gastric ulcer. PRACTICE OF MEDICINE. Answer any ten questions, but no more. 1. Describe autointoxication. 2. Describe ulcerative keratitis. 3. Describe a case of cholelithiasis. 432 MEDICAL RECORD. 4. Differentiate melancholia and dementia. 5. Describe Widal's serum test and its value. 6. Describe a case of cerebrospinal meningitis. 7. Describe a case of incipient tuberculosis of the lung. 8. How does paralysis of the third nerve effect the eye? 9. Describe (1) functional and (2) organic heart mur- murs. 10. Describe rales and give the location and significance of each. 11. Describe renal casts and give the location and signi- ficance of each. 12. Describe, (1) vesicular and (2) bronchial breathing, and in what condition does the latter replace the former? 13. Describe, step by step, an uncomplicated case of lobar pneumonitis terminating in recovery. 14. Describe the eruption of (1) measles, (2) scarlet fever, (3) smallpox, (4) chickenpox, and (5) typhoid fever. 15. Differentiate the coma of (1) opium poisoning, (2) alcoholism, and (3) compression of the brain from frac- ture of the skull. SURGERY. Answer any ten questions, but no more. 1. How would you treat fracture of the internal condyle of the humerus? 2. Give indications for inguinal colostomy. Describe the operation. 3. Accidents of anesthesia? How guarded against? How treated? 4. Diagnosis and treatment of varicocele. 5. Give diagnosis and treatment of empyema. 6. Diagnosis of cancer of the stomach. 7. Define volvulus ; give treatment. 8. Describe how you would close the abdomen after median section. 9. Symptoms and treatment of dislocation of the semi- lunar cartilages of the knee-joint. 10. Diagnosis of renal tuberculosis. 11. Discuss septicemia. 12. Give treatment of ophthalmia neonatorum. 13. Give causes, symptoms, and treatment of mastoid- itis. 14. Describe technique of operation for carcinoma of the breast. 15. Treatment of syphilis. OBSTETRICS AND GYNECOLOGY. Answer any ten questions, but no more. 1. Describe pelvimetry, its uses, and name five of the most important measurements. 433 MEDICAL RECORD. 2. Tell the method of diagnosing (a) ordinary preg- nancy, (b) multiple pregnancy, (c) ectopic pregnancy. 3. Name the various uses to which the tampon may be put in obstetrical practice and the kind and method of use in the several conditions for which you advise it. 4. Describe the third stage of labor, the dangers which attend it and outline your method of conducting it. 5. Describe the urinary changes during pregnancy. 6. Through what agencies may puerperal infection occur ? 7. Describe the principal varieties of puerperal infection and briefly outline laceration. 8. Describe the operation for immediate repair of a complete perineal laceration. 9. Describe three operative measures for the relief of prolapsus uteri. 10. Describe uterine curettage and name three condi- tions which call for it. 11. Describe the operation for (a) ventral suspension of the uterus, (b) ventral fixation. 12. What is the Alexander operation and the reasons for or against it? 13. Name the different types of uterine hemorrhage and their causes. 14. Outline treatment for any one type of uterine hemorrhage. 15. What causes pyosalpinix, and what is the proper treatment? HYGIENE AND MEDICAL JURISPRUDENCE. Answer any ten questions, but no more. 1. Define disinfectants, _ deodorants, and germicides. What disinfectants are efficient where spores are found? 2. How do you calculate the annual birth and death rate of a given community? Give illustration, e.g.: Last year there were 1,324 deaths and 1,075 births in Trenton, having a population of 90,000; give rate there. 3. Give Pettenkofer's method of determining the per- centage of carbon dioxide in the air. 4. What do you mean by hard water? Give tests for relative hardness of water. 5. Describe good milk; give test for same. What so- phistications and adulterations are usual? 6. Name the usual quarantinable disease and require- ments for each at quarantine. 7. Give directions for making cultures in suspected cases of diphtheria. 8. (a) Describe hygiene and sanitary science. (b) Subdivisions of hygiene. (c) Development of hygiene. 434 MEDICAL RECORD. (d) Uses of hygiene to the public. 9. Describe and give uses of the barometer, ther- mometer, hygrometer, psychrometer, and anemometer. 10. Give influence of humidity, wind, clouds, and climate upon the health. 11. Define the duties of a school physician. 12. How would you proceed to prevent or overcome malaria in any district? 13. Give different systems of house heating, with ad- vantages and disadvantages of each. 14. Describe potable water; give natural sources and varieties of water with characteristics of each. 15. What impurities are found in water? What are their effects upon the animal economy? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS'. State Board of Medical Examiners of New Jersey. ANATOMY. i. The changes which take place in the vascular system at birth: The hypogastric arteries become obliterated; the foramen ovale closes; the Eustachian valves atrophy; the ductus arteriosus and ductus venosus atrophy and become impervious; umbilical vein becomes obliterated. 2. Structure of arteries: See Cunningham's "Anatomy" (1909), page 781; or Gray's ''Anatomy" (1908), page 586. Xerve supply of arteries: Xervi vasorum. Blood supply of arteries: Vasa vasorum. 3. The saphenous veins are formed from the dorsal venous arch. The internal saphenous begins at the inner end of this arch, on the inner side of the foot; it passes upward in front of the internal malleolus, then upward and backward with the internal saphenous nerve, behind the internal condyle of the femur, then upward and outward to the inner side of front of thigh, through the saphenous open- ing, to empty into the femoral vein. The external saphenous begins at the outer end of the arch, on the outer side of the foot; it passes upward be- hind the external malleolus, up along the outer side of the tendo Achillis, with external saphenous nerve, to the pop- liteal space, where it enters the popliteal vein. 4. Tonsils. Blood supply: Ascending palatine, tonsillar, ascending pharyngeal, descending palatine, and dorsalis linguoe arteries. Nerves: Tonsillar plexus, formed from glossopharyngeal and pharyngeal plexus. 435 1. MEDICAL RECORD. 5. See Cunningham's "Anatomy" (1909), page 1140; or Gray's ^ "Anatomy" (1908), page 1432. 6. See Cunningham's "Anatomy" (1909), page 431; or Gray's "Anatomy" (1908), page 452. 7. To locate the fissure of Sylvius, draw a line from a point one and a quarter inches behind the external angular process of the frontal bone and the same distance above the zygoma, to a point three-quarters of an inch below the most prominent part of the parietal eminence, (a) The main fissure will correspond to the first three-fourths of an inch along this line ; (b) the horizontal limb will corre- spond to the rest of this line ; (c) the ascending limb will correspond to a line one inch long, going upward (parallel to the coronal suture) from the junction of (a) and (b). Draw a straight line over the top of the scalp from the inion to the glabella ; bisect this line, and half an inch poste- rior to the midpoint draw a line downward and forward at an angle of 67.5 for a distance of three and one-half inches. This line will represent the location of the fissure of Rolando. 8. If the brachial artery is ligated below its profunda branches, the collateral circulation is carried on by the branches of the superior and inferior profunda arteries anastomosing with the recurrent branches of the radial, ulnar, and interosseous arteries. 9. Dura Mater. Description: See Cunningham's "Anat- omy" (1909), page 597; or Gray's "Anatomy" (1908), page 972. Processes: Falx cerebri, falx cerebelli, tentorium cerebelli, and diaphragma sella?. Sinuses: Superior longitudinal, inferior longitudinal, straight, lateral, occipital, cavernous, circular, transverse, superior petrosal, inferior petrosal. 10. The pharyngeal plexus is formed by filaments from the pharyngeal branches of the glossopharyngeal, pharyn- geal branches of pneumogastric and sympathetic nerves. 11. See Cunningham's "Anatomy" (1909), page 628; or Gray's "Anatomy" (1908), page 997- 12. (a) Extensor ossis metacarpi pollicis; (b) Rectus capitis anticus major; (c) Tibialis anticus and posticus acting together. 13. See Cunningham's "Anatomy" (1909), pages 362, 323, and 369; or Gray's "Anatomy" (1908), pages 522, 466, and 533. 14. See Cunningham's "Anatomy" (1909), page 588; or Gray's "Anatomy" (1908), page 938. 15. See Cunningham's "Anatomy" (1909), pages 1254, 789, and 796. PHYSIOLOGY. 1. The uses of the bile are: (1) To assist in the emulsi- fication and saponification of fats ; (2) to aid in the absorp- 436 MEDICAL RECORD. tion of fats; (3) to stimulate the cells of the intestine to increased secretory activity, and so promote peristalsis, and at the same time to keep the feces moist; (4) to elimi- nate waste products of metabolism, such as lecithin and cholesterin; (5) it has a slight action in converting starch into sugar; (6) it neutralizes the acid chyme from the stomach, and thus inhibits peptic digestion; (7) it has a very feeble antiseptic action. 2. The circulating fluids of the body are blood and lymph. The functions of the blood as a whole are : To distribute nourishment, oxygen, and the internal secretions to the tissues of the body; to remove carbon dioxide and other waste matters from the tissues so that they may be ex- creted by the lungs, kidneys, and skin ; to regulate the body temperature. In addition, the white corpuscles serve as a protection to the body from the incursions of pathogenic microorganisms ; they take some part in the process of the coagulation of the blood ; they aid in the absorption of fats and peptones from the intestine, and they help to maintain the proper proteid content of the blood plasma. The functions of the lymph are : To provide the tissues with material necessary to their functional activity, growth, and repair ; to receive from the tissues their waste products, and to convey the products of digestion and absorption to the blood current. 3. Tidal air is the air which is constantly passing in and out of the lungs during ordinary calm respiration. It measures about 30 cubic inches. Residual air is the air which still remains in the lungs after the deepest expirations. It measures about 100 cubic inches. 4. Hemoglobin is the coloring matter of the blood ; it is found in the red corpuscles ; it is crystalline, reddish in color, very complex, and contains iron. Its function is to carrry oxygen from the lungs to the tissues of the body. 5. Too little food decreases both the quantity of milk and the percentage of solids. An ample diet increases both the quantity of milk and the percentage of solids. Abun- dance of proteids in the food increases the fat in the milk ; so also does fat in the food, if it is well digested. Watery food increases the amount of milk, but diminishes the per- centage of solids. 6. The function of the thyroid is not definitely settled; (1) it has some trophic function, regulating oxidation in the body, and it is supposed to have also a special influence on the vasomotor nerves, the skin, the bones, and on the sexual functions; (2) it is supposed to antagonize toxic substances: and (3) it produces an internal secretion. Removal of the thyroid gland causes mental and bodily 437 MEDICAL RECORD. dullness and apathy, tremors, twitchings, overgrowth of the connective tissues, and development of fat; the hairs fall out, and the patient becomes unwieldy and clumsy in both body and mind. The complete removal causes death in most animals, and it is not considered justifiable in man. 7. The coagulation of the blood is due to the develop- ment in it of fibrin. In the plasma a proteid substance exists, called Fibrinogen. From the colorless corpuscles a nucleoproteid is shed out, called Prothrombin. By the action of calcium salts prothrombin is converted into fibrin ferment, or Thrombin. Thrombin acts on fibrinogen in such a way that two new substances are formed; one of these is unimportant and remains in solution ; the other is important, viz., Fibrin, which entangles the corpuscles, and so forms the clot. Lymph also coagulates, but less rapidly, because there is much less fibrinogen present. 8. The respiratory center is in the medulla, at the apex of the calamus scriptorius. (Subsidiary centers are also found in the spinal cord.) "The efferent impulses, which originate in the medulla, are distributed to the various respiratory muscles through the following efferent nerves : The facial, vagus, phrenic, and intercostals. The facial nerve is not much concerned in ordinary respiration in man; a slight elevation of the abe nasi sometimes occurs in inspiration, but it is brought into play in laborious res- piration, and in some animals. The vagus is to some ex- tent an efferent respiratory nerve, inasmuch as it supplies the muscle of the bronchi, and acts as a trophic nerve to the lungs. The chief nerves are the phrenics, which sup- ply the diaphragm, and those which are distributed to the other muscles of ordinary inspiration." — {Aids to Physi- ology.) 9. Heat is produced in the body by: (1) Muscular ac- tion; (2) the action of the glands, chiefly of the liver; (3) the food and drink ingested; (4) the brain; (5) the heart; and (6) the thermogenetic centers in the brain, pons, me- dulla, and spinal cord. Heat is given off from the body by: (1) The skin, through evaporation, radiation, and conduction; (2) the expired air; (3) the excretions — urine and feces. 10. They are all secretions, but urine is also (and chiefly) an excretion ; perspiration and bile are also excretions. 11. Immediate effects of cutting the sciatic nerve would be : Loss of motion in all the muscles below the knee ; also in biceps, semimembranosus, semitendinosus, and adductor magnus; anesthesia in same parts; vasomotor disturbances (the limb becoming first hyperemic, later colder and with diminished blood supply). The remote effects would be: The divided ends retract and become bulbous; Wallerian degeneration occurs in the 438 MEDICAL RECORD peripheral part ; the affected muscles atrophy and the "re- action of degeneration'' is observed ; trophic changes occur in the skin. 12. Causes of bodily fatigue: Presence of sarcolactic acid and acid potassium phosphate in the muscle ; using up of the material from which the energy is obtained, and accumula- tion of waste products. 13. Superficial reflexes are such as can be elicited by stimulating the skin. Four examples: The cremasteric re- flex, plantar reflex, gluteal reflex, and abdominal reflex. Deep reflexes are such as are elicited by stimulating tendons or muscles. Four examples: The patellar reflex ankle clonus, Tendo Achillis reflex, and triceps reflex (el- bow jerk). 14. "Great humidity of the air causes lessened evapora- tion from the lungs and skin. For the air, being saturated, or nearly so, with moisture, has little drying power, and the moisture from the skin and lungs is with difficulty evaporated. The evaporation of moisture, by which much heat is rendered latent, is one of the chief sources of cool- ing the body. Consequently, when the air is hot and very moist, the humidity tends to increase the effects of the heat ; the blood is with difficulty kept at its proper tem- perature ; and all the disagreeable results of the high tem- perature are intensified. Moreover, the humidity of the air affects the climate of a place by hindering the terrestrial radiation of heat." — (Parkes' Hygiene.) 15. The anterior roots of the spinal nerves are efferent and motor, and cause contraction of the muscles to which the nerves are distributed. The posterior roots of the spinal nerves are afferent and sensory, and are distributed to the skin. There are thirty-one pairs of spinal nerves. MATERIA MEDICA AND THERAPEUTICS. i. Aconite, (a) and (b) Official preparations, with adult dose: Fluid extract, TTJ2J ; tincture, TTPx. (c) Medici- nal uses: For fevers, some inflammatory conditions, in high arterial tension, in nervous palpitation of the heart, and congestive dysmenorrhea ; also externally for neural- gia, pruritis, herpes, chilblains, etc. (d) Therapeutic effects: First stimulates and then paralyzes heart and also sensory nerves; lowers blood pressure; dilates peripheral blood vessels; is a respiratory sedative; reduces body tem- perature; is a diuretic and diaphoretic. 2. Strychnine, (a) Indications for use: Impaired di- gestion, cardiac weakness, pneumonia, phthisis, amenor- rhea, dysmenorrhea, impotence, some forms of paralysis, chorea, epilepsy, neuralgia, insomnia, alcoholism, (b) Dos- age: 1/64 grain, (c) The symptoms of poisoning by 439 MEDICAL RECORD. strychnine are "a sense of suffocation, thirst, tetanic spasms, usually opisthotonos, sometimes emprosthotonos, occasion- ally vomiting, contraction of the pupils during the spasms, and death, either by asphyxia during a paroxysm, or by exhaustion during a remission. The symptoms appear in from a few minutes to an hour after taking the poison, usually in less than twenty minutes, and death in from five minutes to six hours, usually within two hours." Treatment : "The convulsions are to be arrested or miti- gated by bringing the patient under the influence of chloral or chloroform as rapidly as possible; the stomach is to be washed out and the patient is to be kept as quiet as pos- sible." — ( Witthaus' Essentials of Chemistry.) 3. Purgatives acting on small intestines: Calomel, dose gr. v; castor oil, dose 3ss ; jalap, dose gr. xx; podophyllin, dose, gr. 1/5 (of the resin); rhubarb, dose gr. xx; scam- mony, dose gr. vij ; senna, dose 3j. On large intestine: Colocynth, dose gr. iij (of the extract) ; elaterium, dose gr. 1/6 ; gamboge, dose gr. viij ; aloes, dose gr. vij ; magnesium sulphate, dose Jss ; potassium bitartrate, and sulphate, dose (of each) gr. xxx; sodium sulphate, dose Jss. 4. The official preparations of arsenic, with their doses, are: Arseni trioxidum, gr. 1/30; Liquor acidi arsenosi, rrgvij ; Arseni iodidum, gr. 1/20; Sodii arsenas, gr. 1/6; Sodii arsenas exsiccatus, gr. 1/20; Liquor potassii arsenitis, tT)?vij ; Liquor sodii arsenatis, TT^v ; Liquor arseni et hydrar- gyri iodidi, TTJ^vij. 5. For acute ptomain poisoning: ]£. Magnesii sulphatis 3vj. Signa. To be given at once, dissolved in water. 6. (a) "The galvanic current is constant and continuous; it always flows in the same direction; it has decided chem- ical and thermal effects. The faradic current is a rapid succession of waves or momentary impulses; the direction is not constant ; the chemical and thermal effects are almost imperceptible. The brain and nerves of special sense re- spond more quickly and decidedly to the galvanic current than to the faradic." (b) Galvanic current is best when the brain, spinal cord, and sympathetic system are to be influenced ; also ior mid- dle and internal ear and retina; and in neuralgia, rheu- matism, and muscular atrophy. Faradic current is indi- cated in diseases of the abdominal viscera, and in general muscular debility. 7. (a) Nitroglycerin dilates the arteries; (b) Aconite dilates the arteries; (c) Digitalis constricts the arteries; (d) Veratrum viride dilates the arteries; (e) Strophan- thus constricts the arteries. 8. See below : Practice of Medicine, question 5. 440 MEDICAL RECORD g. Podophyllin is a slow, drastic, cholagogue cathartic; dose, gr. 1/4. Cascara sagrada is a simple laxative ; dose, gr. xv. Aloin is a cholagogue purgative, acting mainly on the large intestine; dose, gr. j. 10. Acetanilid, dose gr. iv ; is an antipyretic, analgesic, diuretic, diaphoretic, cardiac depressant, and an antiseptic. It is used in fevers, neuralgia, dysmenorrhea, headaches, and as a dressing for wounds, ulcers, and venereal sores. Heroin, dose gr. 1/10; is used to control cough, as it is a respiratory sedative. Terebene, dose irgviij ; is a diuretic and an expectorant; it is used externally as a dressing for ulcers and wounds ; internally in bronchitis, emphysema, phthisis, and in genito- urinary diseases. 11. See French's "Practice of Medicine" (1907)* P a § e 178; or Osier's "Practice of Medicine" (1909), page 192. 12. Morphine: "At first there is usually a period of ex- citation, marked by restlessness, great physical activity, loquacity, and hallucinations. The patient then becomes weary, "dull, and drowsy ; he yields to the desire for sleep, from which at first he may be roused. The lips are livid, the face pale, the pupils contracted, and the sur- face bathed in perspiration. The condition of somnolence rapidly passes into narcosis. The patient cannot be roused, and lies motionless and senseless, with completely relaxed muscles. The pulse, at first full and strong, becomes feeble, slow, irregular, and easily compressible ; the respira- tion slow, shallow, stertorous, and accompanied by mucous rales. The patient rapidly becomes comatose, and, in fatal cases, dies in from forty-five minutes to rifty-six hours, usually in from twelve to eighteen hours. In cases of recovery after the stage of narcosis the pulse and respira- tion gradually return to the normal, and the condition of coma passes into one of deep sleep, lasting twenty-four to thirty-six hours." Carbolic acid: "Those portions of the skin and mucous membrane which have been in contact with the poison are whitened and hardened. There are burning pains in the mouth, esophagus, and stomach, and vomiting; lowering of the pulse and temperature, contraction of the pupils, stupor, syncope, and collapse, terminating in death. The urine, clear and of the normal color when voided, becomes rapidly greenish, and finally dark olive-green or almost black." Arsenic: The symptoms "usually begin in from twenty to forty-five minutes. Nausea and faintness. Violent, burning pain in the stomach, which becomes more and more intense, and increases on pressure. Persisting and distressing vomiting of matters, sometimes brown or gray, 441 MEDICAL RECORD or streaked with blood, or green (Paris green), or black, or blue (charcoal or indigo powder mixed with As 2 2 ). Purging. More or less severe cramps in the lower extremi- ties/' — (Witthaus' Essentials of Chemistry and Toxic ol- ogy.) 13. Pilocarpine hydrochloride is derived from Pilocarpus Jaborandi. The dose is gr. 1/5. It causes increase of saliva and of perspiration; increased peristalsis; it increases and then diminishes blood pressure and heart action ; it causes the pupil to contract, and depresses the nervous system. It is used in Bright's disease, uremia, and whenever a prompt diaphoresis is required. 14. Three vegetable astringents : Tannic acid, dose gr. vij ; gallic acid, dose gr. xv ; hematoxylon, dose gr. xv (of the extract). Therapeutics: Astringent, contract the tissues, hence given in intestinal hemorrhage, diarrhea, hematemesis ; locally to stop bleeding; in leucorrhea, tonsil- litis, pharyngitis, piles, and hyperidrosis. Three mineral astringents: Lead acetate, dose gr. j; silver nitrate, dose gr. 1/5; cerium oxalate, dose gr. j. Therapeutics: The lead acts as a protective and sedative; used as a dressing in in- flammations, bruises, and sprains; as an injection for leucorrhea and gonorrhea. Silver nitrate is used as a caustic ; in ophthalmia neonatorum ; for bedsores, pruritis ; internally for gastric ulcer, chorea, and locomotor ataxia. Cerium is used for vomiting (chiefly that during preg- nancy). 15. Calomel. (a) Source: Mercury. (b) Effects: Diuretic ; cathartic ; healing in venereal ulcers ; anti- syphilitic; for diarrheas and ileocolitis. Overdose pro- duces salivation, (c) Dosage, gr. j to ij. (d) Incom- patabilities : Alkalies, alkaline earths, alkaline carbonates, iron, lead, copper, iodine, chlorides of sodium, potassium, and ammonium, mineral acids, sugar, and soap. chemistry. I. Urea has the formula CO(NH 2 ) 2 ; it "crystallizes in transparent needles or four-sided prisms, without Aq; per- manent in air ; odorless, having a cooling, slightly bitter taste, resembling that of saltpeter. Soluble in an equal weight of cold water, very soluble in boiling water and in five parts of cold water or one part of hot alcohol, the solutions being neutral in reaction. At 248 F. it melts, and slightly above that temperature is decomposed. It is found in the blood, chyle, lymph, humors of the eye, saliva, per- spiration, bile, milk, serous fluids, amniotic and allantoic fluids, and especially in the urine. "It is the principal product of the oxidation of protein substances in the animal body, and is the form in which most of the nitrogen is excreted." 442 MEDICAL RECORD 2. Lithia and the salts of lithium are used in cases of uric acid diathesis, because: (i) They diminish the acidity of the urine; (2) they have a diuretic action; (3) they hasten the excretion of the urates ; (4) and so prevent the accumulation of gravel and the formation of calculi; (5) the lithium salt of uric acid is the most soluble of all the urates. 3. The normal composition of urinary calculi is : Uric acid, sodium urate, ammonium urate, calcium oxalate, cal- cium phosphate, or ammoniomagnesium phosphate. More rarely: Cystin, xanthin, urates of potassium, calcium, or magnesium. 4. Fermentation is the decomposition of organic matter containing carbon, hydrogen, and oxygen only; it occurs in presence of a ferment. When it also contains nitrogen and sulphur the process is called Putrefaction. Decay is slow combustion without the emission of light. 5. The chemical name for white arsenic is arsenic tri- oxide. It is a white, odorless substance; it has a faint metallic taste, is with difficulty soluble in water; it takes up oxygen readily. It is used in the manufacture of green pigments and of glass; as a vermin poison; to preserve material for dissection. 6. The atomic theory regards matter as not being infi- nitely divisible, but as being composed of indivisible par- ticles called atoms. Dalton, by ascribing to each atom a relative weight as compared with the weight of other atoms, was able to explain and produce reasons for all the observed numerical laws of chemical combination. 7. The chemical composition of bone is: Tricalcic phos- phate, magnesium phosphate, calcium carbonate, ferric phosphate, and organic matter (chiefly gelatinous matter). 8. The principal pigment of normal urine is urochrome. 9. High specific gravity of the urine may indicate : Dia- betes mellitus, fevers, and chronic parenchymatous ne- phritis. Low specific gravity of the urine may indicate : Diabetes insipidus, chronic interstitial nephritis, contracted kidney, some nervous disorders, albuminuria, hysteria. Transitory low specific gravity may indicate : Hyste- ria, or some nervous disorders, or the ingestion of an abnormal amount of fluids. 10. In the blood the changes take place in the capillaries of the lungs, and are: (1) The giving up of the C0 2 by the venous blood, (2) the absorption of oxygen during inspiration, (3) the blood is cooled, and (4) it also loses a small amount of watery vapor. The changes produced in the air by respiration are : 443 MEDICAL RECORD. Oxygen Nitrogen Carbon dioxide Other gases Watery vapor.. Temperature .. Volume Bacteria Dust INSPIRED AIR. 21 per cent. 79 per cent. 0.04 per cent. Rare. Variable. Variable. Varies. Always present. Always present. EXPIRED AIR. 16.6 per cent. 79 per cent. 4.4 per cent. Often present. Saturated. That of body. Diminished. None. None. Every 100 volumes of blood contain from 50 to 60 volumes of gas; arterial blood contains: Oxygen 20 volumes Carbon dioxide 39 volumes And venous blood contains : Oxygen 8 volumes Carbon dioxide 46 volumes Relations of oxygen to the blood: "Although every 100 volumes of arterial blood contain 20 volumes of oxygen, none is given off under reduced pressure, as in an air- pump receiver, until the oxygen pressure at the surface is reduced to about 5 millimeters (1/5 of an inch) of mercury. As 1 volume of oxygen could not be held in solution under such a pressure even at 6o° F., it is evident that the oxygen is not simply held in solution in the blood. The hemoglobin of venous blood is dark red, and has a strong affinity for oxygen, which it absorbs readily, and becomes of a bright scarlet color — oxyhemoglobin. When oxyhemoglobin is treated with reducing agents or subjected to an oxygen pressure of less than 5 millimeters of mer- cury, it gives up its oxygen and becomes hemoglobin. Oxygen is not held in solution, but a chemical union exists between it and the hemoglobin. It is evident, how- ever, that the union is not a strong one, as reduced pressure is capable of separating the oxygen from its bonds. The hemoglobin of the arterial blood gives up a portion of its oxygen^to the tissues as it passes through the systemic capillaries, so that in venous blood the hemoglobin is par- tially, but not entirely, reduced to the condition of deoxi- dized hemoglobin. Relations of carbon dioxide to the blood: Carbon diox- ide exists in both arterial and venous blood, but its quantity is greatest in venous blood. It is absorbed by the blood in the systemic capillaries, and given off in those of the lungs. The carbon dioxide is combined with the plasma and with the corpuscles, but the plasma contains most. It is partly dissolved in and partly combined with the 444 MEDICAL RECORD plasma, chiefly in the form of sodium bicarbonate. It is given off by the capillaries to the air in the lungs because the carbon dioxide tension in the vessels is higher than that in the alveoli." ii. Specific gravity is the weight of any substance as compared with the weight of an equal volume of another substance taken as a standard under like conditions of tem- perature and pressure. 12. The properties of bile are : A greenish or brownish fluid, alkaline or neutral reaction, sweetish-bitter taste. Specific gravity of about 1030, and it contains about 10 or 12 per cent, of solids. The chief constituents are water and sodium glyeocholate, sodium taurocholate, and pig- ments. 13. Reaction has two meanings: (1) The interaction of two or more substances causing a chemical decomposition ; (2) the action of substances upon certain organic pigments, such as litmus. Reagent is a substance used to bring about a reaction (first meaning above). 14. Marsh's test for arsenic: This test depends on the fact that arsenic hydride is formed when nascent hydrogen acts on a compound of arsenic : H«AsOs + 3H 2 = AsH 3 + 3H 2 0. A small flask fitted with thistle funnel and a delivery tube, as for the production of hydrogen, is used; pure zinc and hydrochloric acid are introduced, and after a short time the hydrogen is ignited. It is advisable to cover the flask with a cloth before igniting the gas, as an explo- sion may happen unless the air has all been driven out. If the materials are pure the hydrogen flame gives no deposit upon a piece of cold porcelain brought into it, but commercial zinc usually contains arsenic. When the purity of the gas is proved, a little solution of arsenite may be poured down the thistle funnel, which will produce a more rapid evolution of eas, and the flame will become larger and perceptibly colored. A piece of cold porcelain^ de- pressed upon the flame will be covered with a deposit of metallic arsenic. The films of arsenic are metallic looking in the thicker places, brownish near^ the edges; they are easily volatized by heat, and dissolve in solution of bleach- ing powder. A portion of the glass tube from which the gas is burned should be heated to redness ;the gas decom- poses and a deposit of arsenic appears on the tube, which may be identified in a similar way, or may be converted into crystals of oxide by cautious sublimation in an open tube. — (Fisher's Elementary Chemistry.) 15. In vegetable life the metabolic changes are chiefly synthetic; the plant absorbs water and carbon dioxide and builds up complex substances. 445 MEDICAL RECORD. In animal life the metabolic changes are chiefly ana- lytic; the animal takes as food complex substances and splits them into simpler substances. HISTOLOGY, BACTERIOLOGY, AND PATHOLOGY. i. There are three varieties of muscle. Voluntary Striated. Long cylinder. 1-5 inches. Many. Peripheral. '.Inltermedlatle. Cross'andtfong. Present. Occasional. In masses called muscles. By will. Charac- teristic Shape. Length Nucleus. Number. Location. Shape. Striations. Sarcolemma. Branches. Arrangement. Control. Smooth. Spindle. 25-200 microns. One. Central. Rod. (Longi- tudinal occasional- ally.) None. (Occasional.) In layers. Not by will, Cardiac. Stubby cylinder. 100-200 microns. One. Central. Oval. Cross and long. None. Always. As a syncytium Not by will. — (Radasch's Compend of Histology.) 2. See Cunningham's "Anatomy" (1909), page 28. 3. See Cunningham's "Anatomy" (1909), page 444. 4. See Cunningham's "Anatomy" (1909), pages 781 and 782; and Gray's "Anatomy" (1908), pages 586 and 722. 5. To make a pure culture: "All that is necessary is to inoculate the liquefied gelatin with the mixture of bacteria, and after thorough agitation so as to separate each cell from its neighbor, to pour the liquid on to the surface of a sterile plate. The gelatin now solidifies and imprisons, as it were, the separated cells. Each of these now multiplies and reproduces its kind; eventually, in the course of a day or two, a small growth, perhaps of the size of a small pin- head, appears. This is called a colony, and since it is de- rived from a single cell it constitutes a pure culture. Such is the principle of the dilution method for obtaining pure cultures. The isolation once accomplished, all that is neces- sary is to transplant the colony to sterile culture media so as to keep up the growth." — {Reference Handbook of the Medical Sciences.) 6. Bacteria multiply by fission. A bacterium about to divide seems to be larger than normal, and if it is a coccus it becomes more ovoid; changes occur first in the nucleus, and the bacterium just falls in two. It has been calculated that a single bacterium could, by fission, produce two in one hour. Fortunately, they seldom obtain food enough to keep up this process for any length of time. 7. Koch's law in regard to the bacterial cause of disease 446 MEDICAL RECORD. is: (i) The microorganism must be found in the tissues, blood, or secretions of a person or animal sick or dead of the disease; (2) the microorganism must be isolated and cultivated from these same sources; it must also be grown for several generations in artificial culture media; (3) the pure cultures, when thus obtained, must, on inoculation into a healthy and susceptible animal, produce the diseases in question, and (4) the same microorganisms must again be found in the tissues, blood, or secretions of the inocu- lated animal. 8. Because the temperature of the air in summer is better adapted for the life and growth of the bacteria. 9. Cultural characteristics that differentiate the colon bacillus and the typhoid bacillus: (1) On gelatin plates the colonies of typhoid develop more slowly than those of colon bacillus. (2) the colon bacillus causes fermentation with produc- tion of gas in media which contain sugar; the typhoid bacil- lus does not. (3) The colon bacillus produces a strong acid reaction and coagulates milk within twenty-four to forty-eight hours ; the typhoid bacillus does not coagulate milk. (4) In peptone solution the colon bacillus produces indol ; the typhoid bacillus does not. (5) The typhoid bacillus gives the Widal reaction with typhoid serum ; the colon bacillus does not. 10. Immunity is the power of resistance of cells and tissues to the action of pathogenic microorganisms. Susceptibility is the quality or condition of being liable to take a disease; it is the converse of immunity. 11. See French's "Practice of Medicine ,, (1907), page 892; or Osier's "Practice of Medicine" (1909), page 687. 12. See French's "Practice of Medicine" (1907), pages 354 and 696; or Osier's "Practice of Medicine" (1909), pages 308 and 644, 13. See French's "Practice of Medicine" (1907), page 535; or Osier's "Practice of Medicine" (1909), page 753- 14. See French's "Practice of Medicine" (1907), page 825; or Osier's "Practice of Medicine" (1909), page 557- 15. See French's "Practice of Medicine" (1907), page 747; or Osier's "Practice of Medicine" (1909), page 471. PRACTICE OF MEDICINE. I. Autointoxication is the condition in which a person is (being) poisoned by the reabsorption of the waste products of his own metabolism, which should have been excreted. The source of the toxins producing this condition is the v body of the person so suffering. V 2/ "Ulcerative keratitis is a term given to designate the loss of corneal tissue from all causes aside from tran- 447 MEDICAL RECORD. matism. (An injury to the cornea produces a superficial defect in the corneal tissue, the walls of which are usually clean. This is known as simple traumatic ulcer of the cornea.) If the walls of a corneal defect are clear, the condition is known as simple ulcer of the cornea. When the walls of the defect assume a grayish appearance and the gray infiltration extends into the corneal tissue the condition is known as one of infiltrative or infectious ulcer of the cornea. In some cases the grayish infiltration, with a defect in corneal tissue, appears at the margin of the cornea, extending along its periphery. The shape of this ulcer causes it to be known as a crescentic ulcer of the cornea. In other cases a grayish infiltration appears in the corneal tissue immediately beneath the epithelium, ex- tending in zigzag lines over a portion of the cornea, caus- ing loss of epithelium eventually in all parts of its course. Its shape eives it the name of serpent ulcer of the cornea. Ulcers are also known .is superficial or deep, according as they affect the superficial or deep layers. In advancing ulceration of the corner pain, referable to the eye and to the parts subjacent, is i lore or less intense, usually being more severe when the superficial layers of the cornea, the epithelium in particular, are being destroyed. Photophobia is a marked symptom. .The iris is frequently involved, and, when it is, pain, referable to the side of the head, is a prominent feature. The patient is unable to use his eyes." — (Miller, McEvoy, and Weeks, on Eye, Ear, Throat, and Nose.) 3. See French's "Practice of Medicine" (1907), page 852; or Osier's "Practice of Medicine" (1909), page 550. 4. Melancholia is a form of insanity in which the patient suffers from excessive mental depression. "Dementia," when confirmed, consists in a total absence of all reasoning power and an incapacity to perceive the true relations of things ; the language is incoherent and the actions are inconsistent; the patient speaks without being conscious of the meaning of what he is saying; memory is lost, and sometimes the same word or phrase is repeated for many hours together ; words are no longer connected in meaning, as they are in mania and monomania." — -(Tay- lor's Medical Jurisprudence.) 5. The Widal test for typhoid fever "depends upon the fact that serum from the blood of one ill with typhoid fever, mixed with a recent culture, will cause the typhoid bacilli to lose their motility and gather in groups, the whole called 'clumping/ Three drops of blood are taken from the well-washed asceptic finger tip or lobe of the ear, and each lies by itself on a sterile slide, passed through a flame and cooled just before use; this slide may be wrapped in cotton and transported for examination at the laboratory. 448 MEDICAL RECORD. Here one drop is mixed with a large drop of sterile water to redissolve it. A drop from the summit of this is then mixed with six drops of fresh broth culture of the bacillus (not over twenty-four hours old) on a sterile slide. From this a small drop of mingled culture and blood is placed in the middle of a sterile cover-glass, and this is inverted over a sterile hollow-ground slide and examined. * * * A positive reaction is obtained when all the bacilli present gather in one or two masses or clumps, and cease their rapid movement inside of twenty minutes." — (From Thay- er's Pathology.) Its diagnostic value is believed by some to be great; others place little reliance on it. It may be absent in cases of typhoid fever ; it may be present for several months after an attack of typhoid; the reaction may not be ob- tained till the third week of the disease; it may be present in other diseases or in perfectly healthy persons. The above have all been urged as objections; certainly only positive results have any value at all. 6. See French's "Practice of Medicine" (1907), page 142; or Osier's "Practice of Medicine" (1909), page 160. 7. The early manifestations of pulmonary^ tuberculosis are: (1) Physical signs: Deficient chest expansion, the phthisical chest, slight dullness or impaired resonance over one apex, fine, moist rales at end of inspiration, expiration prolonged or high pitched, breathing interrupted. (2) Symptoms: General weakness, lassitude, dyspnea on exer- tion, pallor, anorexia, loss of weight, hemoptysis, slight fever, and night sweats. 8. In paralysis of the third nerve: Ptosis, outward devia- tion of the eye, paralysis of accommodation, diplopia, di- lated pupil, and slight exophthalmos are present. 9. Organic murmurs are due to stenosis or incompetency of one or more of the valves of the heart. Functional murmurs are not due to vulvular disease. Organic murmurs may be systolic or diastolic; may be accompanied by marked dilation or hypertrophy, and there will probably be a history of rheumatism or of some other disease capable of producing endocarditis. Whereas a murmur, usually systolic, soft, and blowing, heard best over the pulmonic area, associated with evidences of chlorosis or anemia, and affected by the position of the patient, is a hemic or functional murmur, and denotes as a rule an impoverished condition of the blood. 10. Rales are adventitious respiratory sounds. According to location, rales may be: (1) Laryngeal and tracheal; (2) Bronchial; (3) Vesicular; (4) Cavernous; (5) Pleur- itic. "Rales may be dry or moist. Dry rales occur in bronchitis and asthma, and may be low-pitched snoring sounds (sonorous rales) or high-pitched whistling sounds 4^0 MEDICAL RECORD. (sibilant rales). Moist rales are produced by the passage of the air through liquid, and may be crepitant, subcrepi- tant, or gurgling in character. Crepitant rales are ex- tremely fine and occur at the end of inspiration; they are heard in the first stage of pneumonia and in engorgement and edema of the lungs. Subcrepitant rales are compara- tively few in number, and are heard during inspiration and expiration, in capillary bronchitis, pulmonary edema, hypo- static pulmonary congestion, and incipient phthisis. Gurg- ling rales may be large or small, and are heard during in- spiration and expiration in phthisical cavities, bronchial hemorrhage, in the stage of secretion in bronchitis, and over the trachea." ii. Casts are cylindrical bodies of, albuminoid material formed in the uriniferous tubules of the kidney. Clinical significance of the different varieties of casts: Acute Parenchyma- tous Nephritis. Only a few casts present. Blood casts, epithelial casts, leucocytes. During convalescence fatty casts may be present. Chronic Parenchy- matous Nephritis. Many casts seen. In early stages large hyaline and dark granular casts. In later stages epithe- lial, large, and small granular casts, hya- line casts and com- pound granular cells. Tn acute exacerba- tions on account of the inflammatory processes, there may be present epithelial casts and many leu- cocytes. Chronic Interstitial Nephritis. Few casts present. Large and small hya- line casts, waxy casts, fatty casts, oil droplets. In acute exacerba- tions on account of the inflammatory process, there may be present all varie- ties of casts, especi- ally large and small granular casts. — (Gould and Pyle's Pocket Cyclopedia.) 12. Vesicular breathing is that which is heard normally over the lungs, and is characterized by a soft, breezy, in- spiratory sound, and a shorter, lower, and softer expiratory sound. Bronchial breathing is that which is heard nor- mally over the trachea or larynx. It is characterized by an entire absence of all vesicular quality ; inspiration is high pitched and tubular; and expiration is longer, higher, and of greater intensity; there is an interval between the two sounds. Bronchial breathing replaces vesicular breath- ing when the lung is consolidated (as in pneumonia and phthisis). 13. See French's "Practice of Medicine" (1907), page 156; or Osier's "Practice of Medicine" (1909), page 172. 14. See French's "Practice of Medicine" (1907), pages 450 MEDICAL RECORD 3^7, 318, 302, 313, and 77 ; or Osier's "Practice of Medicine' (1909), pages 142, 132, 116, 129, and 74. 15. Coma from Intracra- nial Injury. Deep coma; may have history of onset after fall or injury. Evi- dence of fracture of vertex or base. Pupil dilated on side of lesion. Choked disc. Pulse very slow. Respiration slow and ; stertorous. Temperature higher — 101° Urine normal or con- tains trace of al- bumin. Hemiplegia on oppo- site side to that of injury. If contu- sion of brain is also present, may have generalized convul- sions. Alcoholic Coma. Opium Poisoning. Can be aroused by Can be aroused un- supraorbital pressure less very deep. unless very pro- found. Pupils normal or Pupils contracted to somewhat dislated. pinpoint size. Pulse than full. Regular respiration more rapid i Pulse rapid, may be normal and ! irregular. May be low or nor- mal. Normal. Respiration very slow — may be 6 to 8 per minute. Normal. (Eisendrath.) SURGERY. i. See Rose and Carless' "Surgery" (1908), page 513; or Da Costa's "Surgery" (1908), page 494. 2. See Rose and Carless' "Surgery" (1908), pages 1025 and 1027; or Da Costa's "Surgery" (1908). page 963. 3. See Rose and Carless' "Surgery" (1908), page 1325; or Da Costa's "Surgery" (1908), page 1034. 4. See Rose and Carless' "Surgery" (1908), page 1270; or Da Costa's "Surgery" (1908), pages 1202 and 397. 5. See Rose and Carless' "Surgery" (1908), page 927; or Da Costa's "Surgery" (1908), page 773- 6. See Rose and Carless' "Surgery" (1908), page 996; or Da Costa's "Surgery" (1908), page 823. 7. See Rose and Carless' "Surgery" (1908), page 11 13; or Da Costa's "Surgery" (1908), pages 837 and 841. 8. See Rose and Carless' "Surgery" (1908), page 964; or Da Costa's "Surgery" (1908), page 908. 9. See Rose and Carless' "Surgery" (1908), page 635; or Da Costa's "Surgery" (1908), pages 607 and 635. 10. See Rose and Carless' "Surgery" (1908), page 1172. 11. See Rose and Carless' "Surgery" (1908), page 83; or Da Costa's "Surgery" (1908). page 105. 451 MEDICAL RECORD. 12. Treatment of ophthalmia neonatorum. Prophylac- tic: Whenever there is the possibility of infection, or in every case, wash the eyelids of the new-born child with clean worm water, and drop on the cornea of each eye one drop of a one or two per cent, solution of nitrate of silver, immediately after birth. Curative: Wash the eyes care- fully every half hour with a saturated solution of boric acid; pus must not be allowed to accumulate. Two drops of a two per cent. • solution of nitrate of silver must also be dropped on to the cornea every night and morning. The eyes must be covered with a light, cold, wet compress. The patient must be isolated, and all cloths and compresses used must be burnt. 13. See Rose and Carless' "Surgery" (1908), page 885. 14. See Rose and Carless' "Surgery" (1908), page 955; or Da Costa's "Surgery" (1908), page 1236. 15. See Rose and Carless' "Surgery" (1908), page 155; or Da Costa's "Surgery" (1908), page 288. obstetrics and gynecology. 1. See Williams' "Obstetrics" (1909), page 683; or Hirst's "Obstetrics" (1909), page 448. 2. See Williams' "Obstetrics" (1909), pages 180, 366, and 647; or Hirst's "Obstetrics" (1909), pages 204 and 304. 3. See Williams' "Obstetrics" (1909), page 476. 4. See Williams' "Obstefc-ics" (1909), pages 229, 292, and 298; or Hirst's "Obstetrics" (1909), pages 339 and 433. 5. See Williams' "Obstetrics" (1909), pages 189 and 201; or Hirst's "Obstetrics" (1909), pages 252 and 186. 6. See Williams' "Obstetrics" (1909), page 866; or Hirst's "Obstetrics" (1909), pages 715 and 725. 7. See Williams' "Obstetrics" (1909), pages 852 and 316; or Hirst's "Obstetrics" (1909), pages 723 and 333. 8. See Williams' "Obstetrics" (1909), page 325; or Hirst's "Obstetrics" (1909), pages 607 and 867. 9. Prolapsus uteri. Operative treatment gives the most satisfactory results in prolapse. In slight cases of prolapse repair of the perineum will effect a cure. The severer grades will require, in addition, some operation on the anterior vagina. The best of these is Martin's operation for cystocele. If the cervix is hypertrophied it should be amputated. Three operations — on the perineum, for cysto- cele, and amputation of the cervix — are required in the usual case of prolapse. In addition, hystrorrhaphy may be advisable, since there can be no prolapse so long as the uterus maintains its normal position of anteflexion. These operations failing, hysterectomy may be performed. For perineorrhaphy see Rose and Carless' "Surgery" (1908), page 1280. For radical cure of cystocele: "The patient is placed in dorsal position. The posterior vaginal wall is AS* MEDICAL RECORD kept out of the way with a weighted speculum. The cervix is drawn down with a bullet forceps. With a pair of tenac- ula the sides of the prominence are drawn together in the median line in order to see how much of the wall is redundant, and these points are marked with small nicks. Next, the whole surface is put on the stretch between four pairs of forceps — one at each of the sidemarks, one near the cervix, and one at the transverse ridge at the inner end of the urethra. With a pair of scissors curved on the flat, a strip about J4 mcn wide is cut out of the mucous membrane. Similar strips are removed on both sides until an oval is denuded. Finally a running suture of chromicized catgut is passed under the whole pared surface, uniting the edges from side to side." If neces- sary, a perineorraphy should be done at the same time. For hysterectomy see Rose and Carless' "Surgery" (1908), page 1283. 10. Curettage. Indications: For diagnosis, to remove pieces of retained placenta or decidua, endometritis, mucous polypi, hemorrhage, dysmenorrhea, endocervicitis. Dangers: Sepsis, perforation of uterus, hemorrhage, abortion, inflam- mation of uterus or adnexa. Procedure: All antiseptic and aseptic precautions are necessary, the patient should be in the dorsal position, the vagina is to be disinfected, and the cervical canal dilated; a speculum is introduced into the vagina and the cervix is drawn down with volsella; the uterine cavity is irrigated with creolin or lysol; a curette is inserted to the fundus and moved down to the internal os ; the operator should begin at one cornu, and go in the same direction all around till he reaches the starting point, and if necessary repeat till no more spongy or hyperplastic tissue appears ; the fundus should be scraped separately by moving the curette along it from side to side; in going towards the fundus no scraping should be done, and care must be taken not to perforate the uterus ; should this happen, no fluid must be injected: otherwise the uterus and vagina are again irrigated, and one or more strips of iodoform gauze are inserted into the cavity to act either as a hemostatic plug or as a drain, which is diminished with two days' interval and withdrawn on the sixth day. A hemostatic tampon should be placed in the vagina and withdrawn the following day. If anv fever arises the tampon is at once removed and the vagina douched with antiseptic fluid every three hours. If not, the vagina is only swabbed with the same every day and packed loosely with iodoform gauze. After the final re- moval of the gauze the antiseptic douche is given twice a day until there is no more discharge. The patient should remain in bed for a week. 11. (a) See Hirst's "Obstetrics" (1909), page 918. 453 MEDICAL RECORD. (b) See Rose and Cariess' "Surges" (1908), page 1278. 12. See Rose and Cariess' "Surgery" (1908), page 1278. 13. The following (from Gould and Pyle's Cyclopedia of Medicine and Surgery) is a useful classification of uterine hemorrhages, and also gives the causes of the same : I. Hemorrhages Complicating Pregnancy, Labor, or the Puerpetium: A. Hemorrhages of Pregnancy: caused by (1) pla- centa prsevia; (2) premature separation of a nor- mally situated placenta; (3) apoplexy of the de- cidua or placenta. B. Hemorrhages of Labor: caused by (1) placenta prsevia; (2) premature separation of a normally situated placenta; (3) relaxation of the uterus; (4) laceration of the cervix; (5) rupture or inversion of the uterus. C. Hemorrhages of the Piter perium: caused by (1) retained secundines ; (2) displaced uterus; (3) dis- placed thrombi; (4) fibroid tumors; (5) hypertro- phied decidua; (6) carcinoma. II. Hemorrhages Occurring in the Non-Pregnant Woman: A. In * irgins Before the Age of Thirty: caused bv (1) uterine congestion, the result of cold or exposure ; (2) endometritis; (3) polypi and fibroid tumors. B. In Married Women Before the Age of Thirty: caused by (1) subinvolution; (2) laceration of the cervix; (3) endometritis; (4) retrodisplacements of the uterus; (5) polypi and fibroid tumors. C. In Women After the Age of Thirty: caused by (1) carcinoma of the cervix; (2) carcinoma of the body of the uterus; (3) sarcoma of the uterus. 14. See Williams' "Obstetrics" (1909), page 821; or Hirst's "Obstetrics" (1909), page 587. 15. See Rose and Cariess' "Surgery" (1908), page 1288. HYGIENE AND MEDICAL JURISPRUDENCE. 1. Disinfectants are agents which restrain infectious dis- eases by destroying or removing their specific poisons. Deodorants are substances which destroy the odorous products of putrefaction. Germicides are agents which destroy bacteria and their germs. Where spores are found the prolonged application of steam under pressure, or fractional sterilization, will be found efficient. 2. From the figures given the birth rate in Trenton would be : 1,075 * 1,000 =11.9 per thousand. 90,000 454 MEDICAL RECORD. Similarly, the death rate would be : 1,324 X 1,000 = 14.7 per thousand. 90,000 3. Pettenkofer's method of determining the percentage of carbon dioxide in the air: A large cylindrical container of known capacity, say, 15 litres, is filled with the air to be examined; a known volume of barium hydroxide is then added and shaken up with the air. The carbon dioxide combines with the barium hydroxide to form a barium car- bonate, which is insoluble, and also incapable of acting upon an indicator. The barium hydroxide employed is of known strength, e. g., it may be of such strength that 1 ex. of the solution neutralizes 1 c.c. of carbon dioxide at nor- mal temperature and pressure. If then we find that 10 c.c. of the barium hydroxide has been neutralized by the carbon dioxide present in the air, we know that 10 c.c. of carbon dioxide is present in 15 litres or 15,000 c.c. of the air examined. 4. A water is said to be hard when it contains in solution certain salts, such as calcium and magnesium salts, which are capable of acting upon soap and forming with it a curdy deposit. To measure the relative hardness of water a standard soap solution is carefully added to a definite volume of the water until a thin, beady lather is produced. The amount of soap solution which must be added to produce this lather increases with the hardness of the water. 5. Good milk is of characteristic color and appearance, has a specific gravity of about 1029 to 1034; total solids 12 to 13 per cent., of which fat is from ^V 2 to 4 per cent. "The comparison of the specific gravity and the amount of cream which rises with the physical characters will give a very good idea of the quality of milk." — (Parkes.) Milk may be sopJ'.isticated or adulterated by: (1) Skimming; (2) the addition of water: (3) the addition of coloring matter, such^ as caramel, annatto, or methyl orange ; (4) the addition of preservatives, as boric acid, formaldehyde, salicylic acid, or salicylates: (5) the addi- tion of arrowroot, flower, sugar, glycerine, chalk, or sodium carbonate. 6. Quarantinable diseases Cholera, yellow fever, small- pox, plague, typhus, leprosy, diphtheria, scarlet fever., measles, mumps, chicken pox, erysipelas. For length of time see index to these diseases in French's or Osier's "Practice." 7. A sterile swab is rubbed over any visible membrane on the tonsils or throat, and is then immediately passed over the surface of the serum in a culture tube. The tube of culture, thus inoculated, is placed in an incubator at 37° C. 455 MEDICAL RECORD. for about twelve hours, when it is ready for examination. A sterile platinum wire is inserted into the culture tube, and a number of colonies of a whitish color are removed by it, and placed on a clean cover slip, and smeared over its surface. The smear is allowed to dry, is passed two or three times through a flame to fix the bacteria, and is then covered for about five or six minutes with a Loeffler's methylene-blue solution. The cover slip is then rinsed in clean water, dried, and mounted. The bacilli of diphtheria appear as short, thick rods with rounded ends; irregular forms are characteristic of this bacillus, and the staining will appear pronounced in some parts of the bacilli and deficient in other parts. 8. (a) Hygiene includes all the principles for the preser- vation of health; Sanitary Science is the practical applica- tion of these principles. (&) Hygiene may be subdivided into: (i) Personal, (2) Public, (3) Private, (4) Military, (5) Marine, (6) School hygiene, and (7) hygiene of occupations. (<:) and (d)^ Hygiene took a large step forward when the study of vital statistics was started. The growth of bacteriology has done most of all to help hygiene. Public opinion, when once educated on proper hygienic lines, will do much to stamp out diseases, prolong life, and protect both the individual and the community from physical and monetary loss. Its use to the public is further shown by its teaching people how to live in a healthy way, how to build healthy and sanitary houses, how to clothe them- selves, how to dispose of excretions and waste matter. 9. Barometer is an instrument for measuring the atmos- pheric pressure. Thermometer is an instrument for meas- uring temperature. Hygrometer is an instrument for measuring the moisture in the atmosphere. Psychrometer is a hygrometer in which the amount of atmospheric mois- ture is determined by the degree of cold necessary to produce its precipitation. Anemometer is an instrument for measuring the velocity of the wind. 10. Humidity: "When the air is very dry, and especially when it is also warm, so that its capacity for taking up moisture is very great, the evaporation from the skin and the lungs is increased. In chronic lung diseases, such as bron- chitis, emphysema, and some cases of phthisis with much congestion of bronchitis, dryness of the atmosphere causes cough and irritation, no doubt from the increased evapora- tion thrown on the lungs. The warm, equable, and fairly moist climates are best suited for the treatment of these complaints. For healthy people in temperate climates the pleasantest degree of humidity is about 75 per cent, of saturation (relative humidity 75)." — (Parkes' Hygiene.) And see above, Physiology, No. 14. 456 MEDICAL RECORD. Wind: "The effect of movement of air (winds) on evaporation is very great. In cold weather a chilly wind, if dry, increases the evaporation, and also lowers the tem- perature of the body by the impact of its cold particles, which absorb the heat of the body, and then pass away to be replaced by more cold air. The skin becomes dry and chapped, and the lungs are irritated. In hot climates a dry, hot wind increases the evaporation enormously. The warm and moist southwest winds are mild and re- laxing, while the dry and colder east and north winds are bracing." — (Parkes' Hygiene.) Clouds: Their influence is undetermined. Climate: A temperate climate, free from extremes of heat and cold, but with a high degree of humidity, is con- ducive to lung troubles and rheumatism. Tropical and sub- tropical climates are favorable for the development of malaria, dysentery, yellow fever, cholera, liver abscess, and numerous parasitical diseases. ii. The principal duties of a school physician are: To prevent the spread of contagious diseases, and to promptly detect any physical defect or illness in children. The prin- cipal means of preventing the spread of contagious diseases in schools are : Regular and efficient inspection by physi- cians ; prompt exclusion and isolation of anyone suffering from a contagious disease, or coming from a house where such disease is ; compulsory vaccination ; compulsory noti- fication of all infections and contagious disease; individual towels, drinking vessels, and other implements ; children who have had a contagious or infectious disease, or who have come from a house where such disease prevailed, should not be readmitted to school until sufficient time has elapsed since the occurrence of the last case to insure safety. 12. Prophylaxis of malarial fever. Individuals should use mosquito netting round their beds and wire gauze in doors and windows, so as to keep out the mosquitos as much as possible. During residence in malarial districts quinine should be taken every morning before breakfast. All pools, stagnant water, etc., where anopheles may breed, should be removed. All mosquitos, larvae, etc., should be destroyed as far as possible. By staying indoors during dusk and darknesss, opportunities for infection may be avoided. Occasional fumigation with formaldehyde or sulphur is also efficacious. 13. Methods of house heating, (i) Open fires: Waste- ful, only part of room is heated ; but healthy (as ventila- tion is good) and cheerful. (2) Stoves: Heat the whole room, but the air becomes dry and unpleasant, the air is often hotter than the walls and floor, and so chills ensue; carbon monoxide is also produced. (3) Furnaces: Good 457 MEDICAL RECORD Wholesome. heaters and also ventilators. (4) Hot-water pipes: Cleanly and effective, but possibility of overheating the air. (5) Steam pipes: The direct method is not so good, be- cause it does not aid in ventilation; the "indirect" method is good, because it brings in large volumes of heated fresh air. (6) Gas: Good, if properly arranged with outlets over the burners ; otherwise, very injurious. 14. Potable water should be colorless, odorless, cool, limpid, soft; it should have an agreeable taste, neither salty nor sweet nor flat; it should dissolve soap readily without formation of a curdy precipitate ; it should contain not more than about twenty-five to thirty grains of solids per gallon, and should not be polluted with sewage. The sources and varieties of water have been classified thus : 3. Upland surface 1 I water r moderately palatable. (4. Stored rain water. J Suspicious. A 5. Surface water from cultivated") I land I f 6. River water, to which sewage f palatable. Dangerous. -I gains access j [7. Shallow-well water J 15. The impurities found in water are: Sewage, leaves, surface washings, manufacturing refuse, lead, other metals, leakage from gas pipes, insects, fungi, bacteria, entozoa. Impure water may cause typhoid fever, dysentery, diar- rhea, indigestion, goiter, vesical calculi, cholera, yellow fever, scarlet fever, diphtheria, tapeworms, and lead poison- ing. STATE BOARD EXAMINATION QUESTIONS. University of the State of New York. ANATOMY. (Answer ten questions only.) 1. What structures pass through the foramen magnum of the occipital bone? 2. Describe the patella. 3. Distinguish synarthrosis and diarthrosis. Illustrate each. 4. Give the origin, insertion, action, and nerve supply of one of the following muscles : Deltoideus, psoas major (psoas magnus), sternocleidomastoideus, 5. Mention the openings and the valves of the left ven- tricle of the heart. 6. Give the origin, course, and distribution of the arteria pulmonalis. 458 MEDICAL RECORD. 7. Describe the venae intercostales. 8. Locate and describe the lymph nodes of the head. 9. Give the origin, course, and distribution of the nervus ischiadicus f great sciatic nerve). 10. Describe the nasal fossae. 11. Give the structure of the stomach. What is the aver- age size of the adult stomach. 12. Give the gross anatomy of the tongue. 13. Describe the pelvis of the kidney. 14. Describe the urogenital triangle (urethral perineum). 15. Give position and the shape of the pancreas. PHYSIOLOGY. (Answer ten questions only.) 1. What are the general functions of epithelium? What are the specific functions of ciliated epithelium? 2. Explain the dangers of transfusing blood from lower animals into man. 3. What are the forces that cause the circulation of the lymph ? 4. Describe the mechanical relation of the ribs to the vertebrae. Explain the relation of this arrangement to res- piration. 5. Give three examples of enzymes and state the specific functions of each. 6. Describe the plicae circulares (valvulae conniventes). Where are they found, and in what numbers? What pur- pose do they serve? 7. Mention in order of importance the avenues through which the heat of the body is lost. 8. ^escribe the glycogenic function of muscle. 9. What is the origin of urea? 10. Is a muscle dependent on its nerve connection for the reception of a stimulus? Explain. 11. Describe the effects of paralysis of the nervus facialis 12. Describe the. tuba auditiva (Eustachii), and state its function. 13. Illustrate by diagram or otherwise the formation of the image of an object on the retina, considering the re fractive surfaces of the eye as a biconvex lens. 14. State the physical changes in the human body that are characteristic of senility. 15. What is the significance of the presence of polynu- clear leucocytes in the blood? CHEMISTRY. (Answer ten questions only.) 1. Give the graphic formula of (a) sulphur trioxide, (b) phosphoric acid. 2. Give the meaning and illustrate the use in chemical nomenclature of (a) id, (b) ous, (c) ic, (d) hypo, (e) per 459 MEDICAL RECORD. 3. State the centigrade and the Fahrenheit registration of (a) the boiling point of water, (b) the freezing point of water, (c) the freezing point of mercury. 4. Define and illustrate (a) distillation, (b) pentad ele- ment, (c) molecular weight, (d) gas, (e) acid salt. 5. Describe H2O2 as to (a) preparation, (b) uses, (c) test by which it may be recognized. 6. Give the occurrence, preparation, properties, and uses of NH 8 . 7. What are the chief sources of iodine? Describe a method of preparing iodine. Give the formulas of five compounds of iodine. 8. Give the preparation, properties, and uses of sulphuric acid. 9. Give the chemical name, the properties, and the chief sources of K2CO3. 10. What is the chemical antidote for poisoning by lead? 11. Give an emergency method of preparing ferric hydroxide for use in a case of arsenic poisoning. 12. Mention the sources of glucose. Give a test for glucose. 13. Describe normal urine as to (a) specific gravity, (J?) reaction, (c) color, (d) constituents, (e) quantity voided in twenty-four hours. 14. Give the formulas of three substances commonly em- ployed as disinfectants. State in detail an approved method of using one of these substances as a disinfectant in a pri- vate house after an infectious disease. 15. Give the relative proportion of water found in (a) gastric juice, (b) human milk, (c) blood, (d) urine. DIAGNOSIS. (Answer ten questions only.) 1. Differentiate cerebrospinal fever and typhus fever. 2. Give the clinical history of a case of bubonic plague. 3. Describe the typical course of scarlatina. 4. Give the symptoms of pernicious anemia. 5. State the diagnostic value of blood count. 6. Give the symptoms of (a) cardiac hypertrophy with dilatation, (b) cardiac hypertrophy without dilatation. 7. What are the characteristics of acute endocarditis? 8. Give the symptoms and the physical signs of chronic bronchitis. 9. Make a diagnosis, by exclusion, of retropharyngeal abscess. 10. What are the symptoms of carcinoma of the stomach? 11. Give the clinical history of a case of invagination of the bowels. 12. Give the signs and the symptoms of acute hepatitis. 460 MEDICAL RECORD. 13. What are the symptoms of pyuria? Give laboratory methods of confirming the diagnosis. 14. Give the symptoms of chorea. 15. Describe an ambulance case of alcoholism, and show how the possibility of its being a case of cerebral hemor- rhage has been eliminated. PATHOLOGY. (Answer six questions only.) 1. Describe the changes in the dura mater in pachy- meningitis. 2. Describe a teratoma (dermoid cyst). 3. Describe the tissue changes in syohilitic ulcer. 4. Differentiate the blood pictures in lymphatic leukemia, Hodgkin's disease (lymphadenoma) and trichinosis. 5. Describe three varieties of thrombus. 6. Describe the tissue changes in an apoplectic area. 7. Describe the appearance of a section of the spinal cord in progressive spinal muscular atrophy. 8. Describe the tissues of the uterus in acute metritis. 9. What is metastasis? What are the most frequent channels of metastasis? BACTERIOLOGY. (Answer four questions only.) 10. Describe and illustrate a spirillum. 11. Describe the streptococcus, and mention two lesions caused by streptococcus infection. 12. Mention and describe the microorganism of influenza. 13. Describe the bacillus diphtheriae. Mention two organ- isms that are frequently found with the bacillus diphtherias in cultures from the throat. 14. Mention and describe the organism that usually causes lobar pneumonitis, and state how its presence can be demonstrated. 15. Give four sources of infection, and state the com- parative importance of each. SURGERY. (Answer ten questions only.) 1. Describe two methods of producing local anesthesia, and mention indications for the employment of each. 2. Describe aseptic wound fever (post-operation rise), and give the theory of its cause. 3. Give the symptoms and the surgical treatment of ischiorectal abscess. 4. what complications should be feared in a wound made by the wad of a toy pistol, and how should such a wound be treated? 4t may cause gastritis, or choleraic diarrhea; (4) the tannin and vegetable acids which it contains are very astringent and acid. Fruits are valuable as food because they fur- nish nutriment, convey water to the system, relieve thirst, stimulate the appetite, improve digestion, give variety to the diet, introduce various salts and organic acids which improve the quality of the blood and react favorably upon the secretions. — (From Thompson's Dietetics.) 8. A milk epidemic is characterized by the suddenness with which it makes its appearance, the sufferers being for the most part attacked at about the same time. The in- fected houses will be found to have been supplied, almost without exception, by the particular milk vendor whose supply is at fault ; but it will occasionally _ happen that infected houses are discovered to which milk has been supplied by a different vendor, this circumstance being often due to the fact that the vendors on their rounds very commonly buy small quantities of milk from each other. Sometimes valuable corroborative testimony im- plicating the milk is forthcoming in the circumstance that some of those in the infected households, who have con- sumed no unboiled milk, have escaped; and that house- holds supplied from the implicated dairy, but in which no 478 MEDICAL RECORD unboiled milk is consumed at all, have entirely escaped. — ( Parkes' Hygiene. ) g. Koumyss is an effervescing fermented liquor, origin- ally made from mare's milk ; but it is now made from cow's milk, with sugar of milk, and allowed to ferment in open tanks, the casein and butter are skimmed off, and the koumyss is bottled during fermentation. Kefir is a fermented drink made from milk by the addi- tion of a special mushroom-like ferment. It contains about four times as much albuminoids (casein, etc.) as koumyss. 10. How antitoxin produces immunitv and effects cure is not known, but theories deduced from observed facts are as follows : "As the various pathogenic bacteria produce the causative toxins of their respective diseases, so the organic ceils of the body, reacting under the stimulus of the poisons thus introduced, immediately proceed to elab- orate defensive bodies, which if produced in sufficient quan- tity will neutralize the effects of the toxins. Residual antibodies remaining in the blood after recovery render the animal immune for a time against the disease. The immunizing and curative effects obtained by the injection of the blood serum of an immunized animal into the circulation of another animal are due either to direct chemical neutralization of the toxins themselves by the antibodies so introduced (Behring, Kitasato), or to a par- ticular influence exerted by the antibodies upon the living cells of the organism which, being affected in two opposite directions, remain neutral to the disease (Buchner). Some authorities hold that these results are due to the conjoint action of leucytic and chemical forces. Ehrlicli's side chain theory assumes that every toxin contains toxophore molecules having direct toxic action, and haptophore mole- cules which combine the toxophores with a similar com- bining group of molecules in the tissue cell of the attacked organism. The tissue cell molecules being destroyed by the toxophores, a rapid and profuse regeneration of similar molecules occurs in side chains, and these molecules over- growing are carried into the circulation, becoming the antitoxin, which acts by combining with the haptophores of newly arrived toxin, using up their combining power before they can reach the tissue cells."— (Potter's Materia Medica, etc.) ii. For disinfecting ships and cargoes, there are used: Formaldehyde: sulphur dioxide, or sulphurous acid; live steam; acid bichloride of mercury. For method of disin- fecting by formaldehyde, see above, Chemistry, 14 12. The principal means of preventing the spread of con- tagious diseases in schools, are : Regular and efficient in- spection by physicians; prompt exclusion and isolation of anyone suffering from a contagious disease, or coming 479 MEDICAL RECORD. from a house where such disease is; compulsory vaccina- tion; compulsory notification of all infections and con- tagious disease; individual towels, drinking vessels, and other implements; children who have had a contagious or infectious disease, or who have come from a house where such disease prevailed, should not be readmitted to school until sufficient time has elapsed since the occurrence of the last case to insure safety. 13. Tuberculosis, • trichinosis, tape-worm, ptomaine poi- soning, echinococcus disease, and anthrax. 14. Malaria: "It has ever been held that the most in- timate relation exists between the soil and malaria, es- pecially prominent in districts abounding in marsh lands. It has been noticed repeatedly that in malarious countries the upturning and excavation of wet or damp soil are commonly followed by the occurrence of the disease among the laborers so engaged; that infection is more common among those who go about at night, and especially among those who sleep out of doors; and that the draining of marsh lands is often followed by the disappearance of the disease. All of these facts are compatible with the theory of transmission by mosquitoes, and it is now accepted generally that malaria is connected with soil conditions only in so far as the latter permit the breeding of the specific mosquitoes." Yellow Fever: "There is no evidence of connection between the soil and outbreaks of yellow fever, although for many years such a relation was assumed to exist. The disease is mosquito-borne." — Harrington's Practical Hy- giene, i 15. (a) In beefy protein; (b) in wheat, carbohydrates; (c) in eggs, protein and fats, predominate. STATE BOARD EXAMINATION QUESTIONS. North Carolina Board of Medical Examiners. anatomy. (Answer only ten questions.) 1. Name the bones of the head and describe the frontal bone. 2. Where does abdominal aorta commence and where does it terminate? Name its branches. 3. Name the principal lobes of the brain and the fissures dividing them. 4. Give the origin and function of the trigeminus (fifth cranial) nerve, and name the divisions of the same. 5. With what bones does the astragalus articulate ? 6. Describe the stomach, give its average size, attach- 480 MEDICAL RECORD. ments, regional location, gross structure, blood and nerve supply. 7. Give origin, insertion, and action and nerve supply of the following muscles : deltoid, soleus, and quadratus lum- borum. 8. Give the surgical anatomy of femoral hernia. 9. Locate and describe the ovaries. 10. Give a histological description of an artery. 11. Describe the rectum. 12. Describe the iris, give its blood and nerve supply. PHYSIOLOGY AND HYGIENE. 1. What evidence is there that the secretion of urine is not a simple process of filtration from the blood? State the probable nature of the stimulation controlling the secre- tion of urine. 2. Explain the structure and use of each of the three coats of blood vessels. 3. Name the principal centers of organic function situ- ated in the medulla oblongata. 4. Give the teachings as to the (a) origin, (b) func- tions, (c) variations in number of leucocytes. 5. Define the functions of carbohydrate foods. 6. Discuss enzymes, giving (a) their general character, (b) six principal ones, where chiefly found, and their re- spective actions in the process of digestion. 7. What is the significance of (a) nitrates and (b) nitrites found in drinking water? 8. Give the prophylaxis of uncinariasis. 9. Discuss municipal supervision of a city's milk supply. 10. Discuss the contamination of air in dwellings conse- quent upon improper lighting, heating, and ventilation. MATERIA MEDICA. 1. Name the organs influenced by (a) a cholagogue, (b) a sialogogue, (<:)an oxy toxic, (d) a diaphoretic, (e) a mydriatic. 2. Give the official name, using the correct Latin termi- nations, of (a) Epsom salts, (b) Dover's powder, (c) calomel, (d) salol, (e) Fowler's solution, (/) Hoffman's anodyne, (g) cod liver oil, (h) sulphonal, (i) aristol, (/) spirit of nitroglycerin. 3. Define a tincture. Name four of the most important official tinctures and state per cent, strength of each. 4. Give the dose of (a) apomorphina? hydrochloridum. (b) arseni trioxidum, (c) chloralum hydratum, (d) atro- pine sulphas, (e) hydrargyri chloridum corrosivum, (/) strychnine sulphas, ~(g) hexamethylenamine, (h) tinctura aconiti, (i) tinctura gelsemii, (/) glandula suprarenalis sicca. 481 MEDICAL RECORD. 5. Give specific treatment for diphtheria and state (very briefly) how the remedy is obtained. 6. Give specific remedy for myxedema. 7. Write a prescription for dysentery. 8. Name four drugs which might be useful as local applications in tonsillitis (official remedies only). 9. Name five agents (not official drugs) which fre- quently cause poisoning. 10. Give specific - antidote for poisoning by (a) bichlo- ride of mercury, (b) arsenic, (c) iodine, (d) opium (emet- ics, stomach pump, etc., being taken for granted). CHEMISTRY AND DISEASES OF CHILDREN. 1. A patient is found with a temperature of 104 Fahren- heit. Express this in Centigrade, (b) Express the equiva- lent of one grain (decimally) in grams. 2. Methyl alcohol: give (a) common name, (d) uses, (e) dangers. 3. Define combustion, and state what takes place when coal is burned. 4. What is fractional distillation? 5. Name four mineral acids used in medicine and give formula of each. 6. Ophthalmia neonatorum : (a) etiology and symp- toms; (by Crede method of prophylaxis; (c) treatment, general and medicinal. 7. Describe Kernig's symptom of cerebrospinal menin- gitis. 8. Give diagnosis and treatment of acute intussusception. 9. Describe the eruptions in (a) chickenpox, (b) small- pox, (c) measles, (d) scarlet fever. 10. Give most common complication in scarlet fever and treatment of same. OBSTETRICS AND GYNECOLOGY. i. Describe the uterus, its normal position, its relation- ship to other organs, and means by which it is held in place. 2. Give symptoms and treatment of placenta prsevia. 3. What is phlegmasia alba dolens? At what time does it occur? What is the treatment? 4. What are the danger signals of impending eclampsia? Give treatment of eclampsia at eighth month of pregnancy. 5. Define abortion^ miscarriage, and premature labor. Give treatment of an incomplete abortion. 6. Give the etiology and treatment of an acute general cystitis. 7. Define plastic operations as applied to gynecology. 8. What is the differential diagnosis between ascites and ovarian cyst. practice of medicine. 1. Give differential diagnosis between peptic ulcer and carcinoma of stomach. 482 MEDICAL RECORD 2. Give physical signs in croupous pneumonia — in the stage of _ solidification, and differentiate from pleurisy with effusion. 3. In aortic and mitral insufficiency, where is the mur- mur heard most distinctly, and its direction of transmission? 4. Give etiology of cerebrospinal meningitis, (epidemic) and characteristic symptoms. 5. Define arteriosclerosis, and give chief causes produc- ing it. 6. Give symptoms of hemorrhage in typhoid fever, and treatment. 7. What is the chief cause of locomotor ataxia? Give symptoms briefly in initial and ataxic stages. 8. What conditions are found in examination of urine and circulation in chronic interstitial nephritis? 9. Give briefly treatment for acute articular rheumatism. 10. Write one prescription for local treatment of ery- sipelas. SURGERY. (Answer only ten questions.) 1. What is pathology and treatment of paronychia? 2. What is pathology and treatment of osteomyelitis of tibia? 3. Describe operation for radical cure of oblique inguinal hernia. 4. Describe operation for acute catarrhal appendicitis. 5. How would you treat a patient who had suddenly ceased to breathe while inhaling chloroform? 6. Describe method of preparing hands for a surgical operation or obstetrical examination. 7. Why do we have abscess of the liver following puru- lent appendicitis? 8. What is the rule as to fixation of joints above and below a fracture? 9. How do you differentiate between chancre and chan- croid? What is period of incubation for each treatment? 10. Describe operation for talipes equinovarus. 11. For the diagnosis of what disease is the Wasser- mann reaction used? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. North Carolina Board of Medical Examiners. anatomy. 1. Bones of the head: Occipital, two parietal, two tem- poral, ethmoid, sphenoid, frontal, two lacrymal, two malar, two nasal, two palate, two superior maxillary, inferior maxillary, vomer, and two inferior turbinated. MEDICAL RECORD. The frontal bone consists of a vertical and a horizontal portion. The external surface of the vertical portion is convex, and presents the frontal eminence on either side of the median line; the superciliary ridges, produced by the frontal sinuses, beneath, below which is the supraorbi- tal arch, forming the upper boundary of the orbit, and terminating on either side in the external angular process, articulating with the malar bone and the internal angular process, articulating with the lacrymal bone, and having at its inner third a notch or foramen, the supraorbital foramen, for passage of supraorbital artery, nerve, and vein. Ascending from the external angular process is the temporal ridge for attachment of temporal fascia. Between the internal angular processes is the nasal notch, for articulation with the nasal bone, and nasal process of superior maxilla, ter- minating below in the nasal spine, and above it projects the nasal eminence, or glabella, marking the location of the frontal sinuses. The posterior surface lodges the anterior lobes of the brain. In the median line is the frontal crest, which gives attachment to the falx cerebri, and terminates below in the foramen cecum. The crest is grooved for longitudinal sinus, and has on either side of it depressions for the Pacchionian bodies. This surface is also grooved for anterior meningeal arteries. The external surface of the horizontal portion is concave, to form the roof of the orbit, and separated from the opposite side by the eth- moidal notch. To the outer side is a depression for the lacrymal gland, and to the inner side one for the pulley of superior oblique. On the margin of the orbital plate are two notches converted into foramina by articulation with the ethmoid, the anterior ethmoidal canal, for passage of nasal nerve and anterior ethmoidal vessels, and the poste- rior ethmoidal canal, for passage of posterior ethmoidal vessels. The internal surface is marked by the convolu- tions of the anterior lobes of the brain. Between the two plates of the vertical portion are the frontal sinuses. It articulates with the parietal, sphenoid, ethmoid, nasal, superior maxillary, lacrymal, and malar bones. Its muscu- lar attachments are three pairs — corrugator supercilii, articularis palpebrarum, and temporal. It is developed from membrane. — (After Young.) 2. The abdominal aorta commences at the aortic opening in the diaphragm, in front of the lower border of the body of the twelfth dorsal vertebra; it terminates at about the body of the fourth lumbar vertebra, where it bifurcates into the two common iliac arteries. Its branches are: Phrenic, celiac axis (gastric, hepatic, and splenic), supe- rior mesenteric, suprarenal, renal, spermatic (or ovarian), inferior mesenteric, lumbar, and sacra media. 3. The principal lobes of the brain are : Frontal, parietal, 484 MEDICAL RECORD. occipital, temporosphenoidal, Island of Reil, and limbic lobe. The principal fissures are : The great longitudinal (separating the two cerebral hemispheres) ; the great transverse fissure (between cerebrum and cerebellum) ; the Sylvian fissure ; the fissure of Rolando ; the parietoocci- pital fissure. 4. Trigeminus (fifth cranial nerve). Origin: Superficial, from side of pons Varolii ; deep, from medulla, and floor of fourth ventricle. Divisions and Functions: First, ophthalmic; sensory to anterior half of scalp, conjunctiva and skin of upper eyelid, cornea, skin of nose, mucous membrane of nose, lacrymal gland. Second, superior max- illary; sensory to conjunctiva and skin of lower eyelid, nose, cheek, upper lip, palate, upper teeth, and alveolar processes. Third, inferior maxillary ; sensory to external auditory meatus, side of head, mucous membrane of mouth, anterior two-thirds of tongue, lower lip, teeth and alveolar processes of lower jaw. It is also motor to the muscles of mastication (temporal, masseter, two pterygoids), mylo- hyoid, and anterior belly of the digastric. 5. The astragalus articulates with : Tibia, fibula, os calcis, and scaphoid (or navicular). 6. Stomach is conical, with base to left side; the upper border is concave, and is called the lesser curvature; the lower border is convex, and is named the greater curva- ture. The left extremity is known as the fundus, above and to the right of which is the cardiac orifice, and the right or small end is termed the pyloric extremity. It occu- pies left hypochondriac and epigastric regions. Its orifices are cardiac, above, communicating with the esophagus; pyloric, at the right extremity, passing into the duodenum. It is 10 to 12 inches long, 4 to 5 inches in diameter at widest part. Its left or cardiac end is fixed by esophagus and gastrophrenic ligament to diaphragm, lying beneath the seventh left costal cartilage, one inch from sternum; it is connected with the spleen by the gastrosplenic omen- tum. The right or pyloric end reaches the gall-bladder, touching under part of quadrate lobe of liver; is very movable ; when stomach is empty is in midline four inches below tip of gladiolus. Anterior surface, which also looks upward, is in contact with, from left to right, diaphragm, abdominal parietes (epigastric region), under surface of liver. Posterior surface is separated from pancreas, crura of diaphragm, aorta, vena cava inferior, and solar plexus, by lesser sac of peritoneum. Superior border is attached to liver by small omentum. Inferior border gives attach- ment to great omentum. Coronary and pyloric arteries run along lesser curvature ; right and left gastroepiploic, along inferior or greater curvature; vasa brevia, from the splenic to fundus. Right pneumogastric nerve supplies to ,0- , MEDICAL RECORD. posterior surface; left pneumo gastric, the anterior sur- face; sympathetic, from the solar plexus, both surfaces. — {Aids to Anatomy.) 7. Deltoid. Origin: From the outer third of anterior border and upper surface of the clavicle, from the outer margin and upper surface of the acromion process, and from the lower edge of the spine of the scapula. Insertion: Into the deltoid impression on the middle of the outer side of the shaft of the humerus. Action: It raises the arm from the side so as to bring it at right angles with the body; its anterior fibers draw the arm forward; its poste- rior fibers draw the arm backward. Nerve supply: The circumflex. Soleus. Origin: From back of head of the fibula, and upper part of the posterior surface of shaft of fibula; from oblique line of tibia, and middle third of internal border of tibia. Insertion: Into lower part of posterior surface of os calcis. Action: To extend the foot, raise the heel; also in walking, standing, dancing. Nerve supply: Internal popliteal and posterior tibial. Quadratus lumborum. Origin: From iliolumbar liga- ment, crest of ilium, and transverse processes of three or four lower lumbar vertebrae. Insertion: Into lower border of twelfth rib and transverse processes of four upper lum- bar vertebrae. Action: It draws down twelfth rib, flexes spine laterally. Nerve supply: Anterior branches of lum- bar nerves. 8. Femoral hernia leaves the abdomen through the fem- oral ring and descends into the femoral canal ; this canal is funnel-shaped, is about half an inch in length, and ends at the saphenous opening. Femoral hernia is always acquired, and has a sac. Its course is first vertical, then forward, then upward over Poupart's ligament. Its cover- ings, from without inward, are : Skin, superficial fascia, cribriform fascia, crural sheath, septum crurale, subserous tissue, and peritoneum. The neck of the hernia is situated at the femoral ring; to its outer side lies the femoral vein, and to its inner side is Gimbernat's ligament; in front of it is Poupart's ligament, and behind it are the pubis, the Pectineus, and the pubic portion of the fascia lata. In the immediate neighborhood of the femoral ring are: Ante- riorly, the communicating branch between the deep epi- gastric and the obturator arteries ; externallv, the femoral vein and deep epigastric vessels ; superiorly, the spermatic cord (or round ligament) and the deep epigastric vessels. 9. The ovaries are two in number, and correspond to the testes in the male; they are of a flattened ovoid form, vertically placed in the posterior part of the broad liga- ment. By its anterior border the ovary is connected to the broad ligament, and by its lower pole to the uterus by a 486 MEDICAL RECORD. proper ligament, extending to the superior angle of the uterus, and called the ligament of the ovary. The lateral surfaces and posterior borders are free. The superior pole and posterior border are embraced by the Fallopian tube ; on its inner surface it is in relation with small intestine in Douglas' pouch, and externally lies in a peritoneal fossa between the external and internal iliac vessels as they diverge. The vessels enter the hilum at the attached ante- rior border. — (Aids to Anatomy.) 10. An artery consists of three coats : The tunica interna, or internal coat; the tunica media, or middle coat, and the tunica adventitia, or external coat. The internal coat consists of a basement membrane, on which is a layer of endothelial cells. The middle coat consists of involun- tary muscle fibers, between the layers of which are some elastic fibers. The external coat consists of connective tissue (white fibrous and yellow elastic). Between the two outer coats is an elastic membrane. ii. The rectum is the lowest part of the alimentary canal, and extends from the sigmoid flexure to the anus. It is about six inches in length, and is divided into three portions. The upper half only is invested with peritoneum. The upper third rests upon the sacral nlexus and the pyri- f ormis muscle ; the middle third is in relation with the bladder, prostate, and seminal vesicles (in the female with uterus and vagina) ; the lower third is surrounded by the sphincters. It is not sacculated; the arteries are the hem- orrhoidal branches of the inferior mesenteric, internal iliac, and internal pudic ; the veins form the hemorrhoidal plexus, and empty into the inferior mesenteric and internal iliac veins. 12. The iris is a thin, circular, colored membrane sus- pended in the aqueous humor, behind the cornea and in front of the lens. It is perforated by a circular aperture — the pupil. It is connected with the choroid, the sclerotic, and cornea. It consists of a stroma of connective tissue, with blood vessels, nerves, pigment cells, and also two groups of involuntary muscle fibers — circular and radiat- ing. Blood supply: Long and anterior ciliary arteries, and short ciliary arteries. Nerves: Ciliary, from lenticular ganglion and nasal branch of ophthalmic division of fifth cranial nerve. PHYSIOLOGY AND HYGIENE. I. Evidence that the secretion of the urine is not a simple process of filtration from the blood rests mainly on the following facts : "i. It has been shown that the renal epithelium does excrete indigo carmine from the blood when a solution of this. material is injected into the veins; by dividing the 487 MEDICAL RECORD. spinal cord to prevent the excretion of water, which would wash away the indigo carmine, after allowing an appropri- ate time to elapse before killing the animal, the epithelium of the convoluted tubules will be found loaded with the indigo carmine. "2. In the amphibia (frogs, newts, etc.), the kidney has a double vascular supply; the glomeruli of the Malpighian bodies are supplied by the renal arteries, and the capillaries of the renal tubules by veins called renal portal veins. By tying the one or the other set of vessels and injecting vari- ous materials into the blood it has been shown that urea is only excreted by the cells of the tubules, and that sugar, peptones, and albumins are only excreted by the glomeruli." — {Aids to Physiology.) The nerves are both vasodilator and vasoconstrictor ; true secretory nerves have not yet been discovered. 2. For structure of the three coats of an artery, see above, Anatomy 10. Veins also have three coats, arranged similarly to those of arteries, but the middle coat possesses less elastic and muscle tissue and more fibrous tissue, hence 'the tendency of veins to collapse when empty. In veins the external coat is the thickest; in arteries the middle coat is the thickest. Veins have valves, as a rule. Functions of the endothelial lining of the inner coat is to make a smooth surface for the circulation of the blood with as little fric- tion as possible. The muscular fibers supply contractility. The elastic fibers supply- elasticity. The connective tissue fibers supply strength and support. 3. The principal centers of organic function situated in the medulla are: (1) Center for mastication; (2) for secretion of saliva; (3) for sucking; (4) for deglutition; (5) for vomiting; (6) for voice; (7) center for expres- sion: (8) cardiac centers; (0) respiratory centers; (10) vasomotor centers. 4. Leucocytes, (a) Origin: Supposed to be formed in the spleen, lymph glands, and lymphoid tissue. (b) Func- tions: (1) To serve as a protection to the body from the incursions of pathogenic microorganisms; (2) they, take some part in the process of the coagulation of the blood; (3) they aid in the absorption of fats and peptones from the intestine, and (4) they help to maintain the proper proteid content of the blood plasma, (c) Variations in number: Normally between 7,000 and 10,000 or 12,000 in each cubic millimeter of blood. 5. The function of the carbohydrate food is to supply animal heat and energy; also to form fats and possibly to help form proteids. 6. Enzymes (a) are substances formed by living cells, which act specifically upon definite substances, and which themselves remain unchanged during this action. Their 488 iMEDICAL RECORD. specific action is shown in the following table. Enzymes are generally soluble in water or saline solution ; they act best at about the body temperature, and are destroyed by high temperatures ; excess of alcohol tends to precipitate them from their solutions ; the enzymes can act almost indefinitely, but the products of their activity must be removed, (b) Six principal enzymes: ENZYMES ORIGIN ACTION ON FOOD MATERIALS Ptyalin. Saliva. Changes starches into dextrin and sugar. Pepsin. Gastric Juice. Changes proteids into proteoses and peptones in an acid medium. Trypsin. Changes proteids into proteoses and peptones, and afterward decom- poses them into leucin ► Pancreatic Juice. and tyrosin ; in an al- kaline medium. Amylopsin. Converts starches into maltose. Steapsin. Emulsifies and saponifies fats. Converts maltose into Invertin. Intestinal Juice. Glucose. 7. (a) Nitrates are generally due to oxidation of organic matter of animal origin. A trace of nitrate, not exceeding N = °-35 per 100,000, would not suffice to condemn a water otherwise pure, (b) Nitrites are due to sewage contami- nation; their presence should condemn the water. They indicate more recent and therefore more dangerous con- tamination than nitrates. 8. Prophylaxis of uncinariasis consists in: (1) Boiling the drinking water; (2) washing of the hands before meals; (3) not going barefooted; (4) disinfection of the stools of all infected persons. 9. Municipal supervision of a city's milk supply. The- oretically, this should be desirable, because: (1) Milk is adulterated very frequently; (2) diseases are conveyed through milk; (3) cowsheds, dairies, and milkshops are often in a most unsanitary condition; (4) persons suffer- ing from infectious diseases are occasionally employed in the mijking or storage or distribution of milk. Municipal supervision might prevent all of this. But experience shows that municipal authorities are not always any more keen than others in doing their duty; graft, persecution, and tyrariny might result; the price of milk would be unduly 489 MEDICAL RECORD. raised, and every political evil might reign supreme. If these evils can be prevented, municipal supervision would be most desirable. 10. The air is contaminated by combustion (in which oxygen is decreased, and there are given off: Nitrogen, carbon dioxide, ammonia, sulphur dioxide, and carbon monoxide) ; respiration (in which oxygen is decreased, carbon dioxide is increased, ammonia and organic matter are produced). Improper ventilation increases all these evils. Various diseases are directly produced, or indirectly induced. MATERIA MEDICA. 1. (a) Cholagogues influence the liver; (b) silagogues, the salivary glands; (c) oxytocics, the uterus; (d) diaph- oretics, the sweat glands; (e) mydriatics, the eye. 2. (a) Epsom salts is Magnesii sulphas; (b) Dover's powder is Pulvis ipecacuanhas et opii; (c) calomel is Hydrargyri chloridum mite; (d) salol is Phenylis salilylas; (e) Fowler's solution is liquor potassii arsenitis ; (/) Hoff- mann's anodyne spiritus setheris compositus; (g)cod liver oil is Oleum morrhuse; (h) sulphonal is Sulphon-metha- num; (i) aristol is Thymolis iodidum ; (/) spirit of nitro- glycerin is Spiritus glycerylis nitratis. 3. A tincture is an alcoholic solution of a medicinal sub- stance. (1) Tincture of aconite, 10 per cent. (2) Tincture of nux vomica, 2 per cent. (3.) Tincture of iodine, 7 per cent. (4) Tincture of digitalis, 10 per cent. 4. Doses, (a) Apomorphinse hydrochloridum, gr. 1/10, as an emetic, (b) Arseni trioxidum, gr. 1/30. (c) Chlor- alum hydratum, gr. xv. (d) Atropinse sulnhas, gr. 1/160. (e) Hydrargyri chloridum corrosivum, gr. 1/20. (/) Strvchninse sulphas, gr. 1/64. ( g) Hexamethylenamine, gr. iv. (h) Tinctura aconiti, tt£x. (i) Tinctura gelsemii, TT^viii. (/) Glandula suprarenalis sicca, gr. iv. 5. Specific treatment for diphtheria is diphtheria anti- toxin ; dose, 3000 units ; immunizing dose for well persons, 500 units. The serum of the blood of the horse, immunized by re- peated injections of diphtheria toxin from cultures of the bacillus. 6. Specific remedy for myxedema — dry thyroid of the sheep. 7. Prescription for Dysentery: 5. Acidi sulphurici aromatici, 3jss. Spiritus chloroform, 3ij. Tincturse opii camphoratae, Jij. Syrupi zingiberis, q.s. ad 3iv. Misce. Signa: Dessertspoonful in water every two hours. 490 MEDICAL RECORD. 8. For local applications in tonsillitis : Alum, guaiacol, hydrogen peroxide, nitrate of silver. 9. Poisoning may be produced by: (1) Illuminating gas, (2) headache powders, (3) ptomaines, (4) snake bite, and (5) fungi (mushrooms, toadstools). 10. Antidote for (a) bichloride of mercury is white of tgg or milk; (b) for arsenic, is freshly prepared solution of ferric hydroxide; (c) for iodine, is starch paste; (d) for opium, is caffeine, or strychnine. CHEMISTRY AND DISEASES OF CHILDREN. 1. Since C° = 5/9 (F°— 32), C° = 5/9 (104 — 32) = 5/9 of 72 =40°. Therefore 104 Fahrenheit = 40 Centigrade. (b) One grain = 0.065 gram. 2. Methyl alcohol. (a) Common name: Wood spirit. (b)Uses: Solvent of resins, sulphur, phosphorus, potash, soda, and volatile oils, (c) Dangers: It should not be used in pharmacy, or taken internally, even when purified, for it has caused blindness and death. 3. Combustion is rapid oxidation with the giving off of light and heat. When coal is burned, the carbon unites with the oxygen of the air, producing carbon monoxide and carbon dioxide; other gases and liquids are also given off, and the coal is decomposed and gradually disappears, only some ashes being left. 4. Fractional distillation is a process by which liquids with different boiling points may be separated in a pure condition; it is largely used in the separation of coal tar products. The temperature of the mixture is gradually raised, so that the components are distilled off successively in the order of their volatility. 5. Four mineral acids: Hydrochloric acid, HC1; nitric acid, HN0 5 ; sulphuric acid, H 2 S0 4 ; phosphoric acid, H 8 PO4. 6. Ophthalmia neonatorum. Causes: The gonococcus or some other pyogenic microorganism; the secretions of the mother contain the infecting agent, and transmission may occur directly during parturition, or indirectly by the fingers of physician or nurse, cloths, instruments, etc. Symptoms: Swollen eyelids, with copious purulent dis- charge; ulceration of the cornea may ensue. Prophylaxis: Whenever there is the possibility of infection, or in every case, wash the eyelids of the newborn child with clean warm water, and drop on the cornea of each eye one drop of a 1 per cent, solution of nitrate of silver, immediately after birth. Treatment: Wash the eyes carefully every half hour with a saturated solution of boric acid; pus must not be allowed to accumulate. Two drops of a 2 per cent, solution of nitrate of silver must also be dropped on to the 491 MEDICAL RECORD. cornea every night and morning. The eyes must be covered with a light, cold, wet compress. The patient must be isolated, and all cloths and compresses used must be burnt 7. Kernig's symptom of cerebrospinal meningitis con- sists in the fact that if the thighs or legs are flexed they cannot then be fully extended, owing to the contracture of the muscles on the posterior of the thigh. 8. Acute intussusception. Diagnosis: Sudden onset, severe localized pain, vomiting, tenesmus, and passage of blood}'- mucus. There is a sausage-like tumor in the abdo- men ; sometimes it can be felt in the rectum. Fecal im- paction or appendicitis may simulate it, but in the former the swelling is less tender and is on the left side ; in the lat- ter there is fever, and the tumor is on the right side. Treatment : Laparotomy and reduction of the bowel as soon as possible. Gentle manipulations, enemata, and opium have been suggested, but these should be adopted only when surgical relief is not available. 9. (a) In chickenpox: The eruption usually appears first on the trunk, is evident on the first day, comes in successive crops, is not shotty, and disappears on stretch- ing the skin ; the spots are unilocular, and collapse on being punctured, (b) In smallpox: The eruption usually appears first on the forehead and wrists, and on the third or fourth day; it is first macular, then papular, then ves- icular, and finally pustular; it does not appear in succes- sive crops; the spots are multilocular, and do not collapse on being punctured; the papule is hard and shotty, and does not disappear on stretching the skin, (c) In measles: Eruption appears on fourth day as small dark red papules with crescentic borders, beginning on face and rapidly spreading over entire body; desquamation is branny, (d) In scarlet fever: Eruption appears at end of twenty-four hours, as a scarlet puncture rash, beginning on neck and chest then covering face and body; desquamation is scaly or in flakes. 10. Most common complications of scarlet fever are : Arthritis, endocarditis, bronchopneumonia, ear troubles (perforation, deafness), facial paralysis or meningitis, suppuration of cervical glands, nephritis. Treatment, as a rule, same as in nonscarlatinal cases; warm and sedative applications, with cotton wool for arthritis, also alkalies; for the throat, ice to suck, warm applications externally, antiseptic sprays ; tonics and stimulants. A minimum of nitrogenous food to avoid irritating the kidneys. For the nephritis : The patient should be kept in bed, kept quiet, and kept warm. Milk diet should be the rule; the milk can be diluted with limewater or Vichy. Salines, as potas- sium bitartrate or magnesium citrate or sulphate, and diaphoretics, as sweet spirit of niter, or pilocarpin, may 492 MEDICAL RECORD be administered. Warm baths are helpful, and infusion of digitalis should be given. OBSTETRICS AND GYNECOLOGY. i. In the nulliparous adult the uterus is about three inches long, about two inches wide at the upper part, and about one inch thick. The uterus lies between the rectum behind and the bladder in front; it is below the abdominal cavity and above the vagina. Its position is one of slight anteflexion, with its long axis at right angles to the long axis of the vagina. The anterior surface of its body rests on the bladder, and the cervix points backward toward the coccyx. The uterus is not fixed, but moves freelv within certain limits. It is held in place by ligaments — broad liga- ments, round ligaments, vesicouterine, and rectouterine. 2. The symptoms of placenta praevia are: Sudden hem- orrhage, accompanied by syncope, vertigo, restlessness, and feeble pulse. Treatment: Stop the hemorrhage by a vagi- nal tampon; this must be tight and thorough. Accouche- ment force is indicated ; this consists of dilatation of cer- vix, version, and immediate extraction of the child. 3. Phlegmasia alba dolens is a form of manifestation of puerperal sepsis in which there is a thrombosis of the iliac or femoral vein. Sometimes it occurs after a uterine phle- bitis, in which clots are carried from the uterine sinuses to the hvoogastric veins, where they cause obstruction to the blood flow in the crural veins. The trouble may also begin as a crural phlebitis. It is thus due either to cellulitis or to thrombosis. It usually appears about the third or fourth week of the puerperium. Treatment: Liquid and nutritious diet, tonics, stimulants, mild laxatives, opiates, or hyp- notics, absolute rest in bed; the affected limb should be slightly elevated; laudanum or belladonna poultices may be applied. An elastic bandage should subsequently be worn. 4. The danger signals of impending eclampsia are : Head- ache ; tinnitus aurium ; dizziness ; pain over stomach ; diges- tive, visual, and nervous disturbances; general debility; insomnia, vomiting, and vertigo. For preventive treat- ment: (1) The amount of nitrogenous food should be diminished to a minimum; (2) the production and absorp- tion of poisonous materials in the intestines and body tissues should be limited and their elimination should be aided by improving the action of the bowels, the kidneys, the liver, the skin, and the lungs; (3) the source of the fetal metabolic products and the peripheral irritation in the uterus should, if necessary, be removed by evacuating that organ. The curative treatment includes: (1) Controlling the convulsions (by chloroform, veratrum, or chloral) ; (2) elimination of the poison or poisons which are pre- 493 MEDICAL RECORD. sumed to cause the convulsions; (3) emr^ing the uterus under deep anesthesia, by some method that is rapid and that will cause as little injury to the woman as possible. 5. Abortion is delivery of the product of conception be- fore the twelfth week. Miscarriage is delivery of the product of conception between the twelfth and twenty-eighth weeks. Premature labor is delivery of the fetus between the twenty-eighth week and full term. Treatment of an incomplete abortion: Anesthetize the patient, dilate the' cervix, with finger or curette remove all debris, irrigate with saline or antiseptic solution, and keep in bed. 6. Acute cystitis, (a) Etiology: Various pathogenic bacteria, foreign bodies, traumatism, retention of urine, unclean catheters, cold, (b) Treatment includes: Rest, administration of olenty of cold water or milk, diuretics, bland and mild^ food, laxatives, hot sitz baths or vaginal douches, irrigation of the bladder with antiseptic solution followed by solution of nitrate of silver. 7. Plastic operations in gynecology are such as are done : (1) for the repair of lacerations of the perineum or cer- vix; (2) for vaginal fistula? ; (3) for the narrowing of the vagina, and the treatment of cystocele or rectocele; and (4) various other operations on vulva, urethra, or anus. 8. ASCITES. 1. Previous history of visceral disease. 2. Enlargement compara- tively sudden. 3. Face puffy ; color waxy ; early anemia. 4. Patient on back, en- largement symmetrical ; flat in front. 5. Sitting up, abdomen bulges below. 6. Navel prominent and thinned. 7. Fluctuation decidedly clear, diffuse throughout ab- domen, but avoids highest parts in all positions, and always has a hydrostatic level. 8. Intestines float on tor of fluid; hence percussion gives clear tympanitic note OVARIAN CYST. 1. No such history. 2. Gradual. 3. Facies ovariana. Ane- mia absent, or later. 4. Asymmetrical until tu- mor is quite large ; promi- nent in front. 5. No appreciable change. 6. Navel usually unchanged. 7. Less clear; limited to cyst ; not modified by change of position. No hydrostatic level. 8. No change in areas of dullness and resonance with change of position. Dull- 494 MEDICAL RECORD. ASCITES. over the highest parts of abdominal cavity, and dul- ness in lowest parts for all positions — i.e. areas of res- onance and dullness change with position. 9. Vaginal touch detects fluctuation, bulging into va- gina. 10. Uterus in prolapsed lo- cation, but position un- changed. Size and mobility unchanged. n. Hydragogues and diu- retics temporarily remove the fluid. 12. Fluid light straw color and thin. Coagulates spon- taneously. OVARIAN CYST. ness over cyst. Clear res- onant note in all parts be- yond cyst limits, i.e. in flanks and toward the dia- phragm. 9. Vaginal fluctuation less clear or absent. 10. Uterus displaced for- ward or backward, or later- ally by pressure of cyst. 11. Medicines have no ef- fect. 12. Fluid light or dark and of varying consistency ; albuminous, but does not coagulate spontaneously; may contain colloid matter. — (From Dudley's Gynecology.) PRACTICE OF MEDICINE. i. Peptic ulcer is generally caused by injury or bacteria; is most apt to occur between the ages of twenty and forty- five; after eating there is pain localized in the stomach, vomiting occurs soon after eating; hematemesis is com- mon, there is localized tenderness over the stomach, and examination of the gastric contents shows an excess of free HCL Carcinoma of the stomach does not usually occur before forty years of age, is more common in males, the pain is localized and constant, vomiting is copious, and occurs some time after eating; the vomitus contains "coffee ground" material; hemorrhages are common ; a tumor may be palpated, and examination of the gastric contents shows absence of free HC1 and presence of lactic acid; severe anemia and cachexia are also present. 2. In croupous pneumonia, in the stage of solidification, the physical signs are: Diminished chest movement ; in- creased vocal fremitus; absence of vesicular breathing, presence of tubular breathing, increased vocal resonance, bronchophony, or pectoriloquy; dullness on percussion. 495 MEDICAL RECORD. ACUTE PNEUMONIA. Onset very sudden and symptoms severe — convul- sions, etc., cough first, fol- lowed by pain in the side. Temperature very high, 104 or often 105 F. Pulse- respiration ratio greatly disturbed. Bright crimson flush on the cheeks, and the muscular prostration is consider- able. Cough is short and hack- ing or in paroxysms; and the sputum, when brought up, is rusty and tenacious. Organs not displaced. Dullness on percussion not complete, and the sense of resistance almost nil. Respiratory sounds tubular, and fine crepitation heard at border of consolida- tion. Vocal resonance increased. Vocal fremitus increased. The physical signs are lim- ited to the front or back of the chest. EXUDATIVE PLEURISY. Onset moderately sudden, and symptoms not severe- chilliness and pain in the side, followed by cough. Temperature not high, 101.5 or 102 F. Pulse-respiration ratio not disturbed. Face is pale, and there is little loss of muscular power. Cough is dry and painful, and patient tries to re- press it. Organs displaced. Dullness complete, with sense of great resistance. Respiratory sounds much diminished, and friction heard at upper margin of effusion. Vocal resonance greatly di- minished. Vocal fremitus diminished or absent. The physical signs are found both at the back and front of the affected side. 3- Aortic Insufficiency. . Mitral Insufficiency. . MURMUR HEARD BEST. Second right in- tercostal space. At apex. TRANSMITTED. Down sternum, and towards apex. Left axilla and an- gle of scapula. 4. Cerebrospinal meningitis. Etiology: The diplococ- cus intracellularis of Weichselbaum, or streptococcus pyo- genes, or pneumococcus. Characteristic symptoms: Sudden onset, very severe pain in neck, back of head and spine, head is strongly retracted, causing opisthotonos, Kernig's sign (see above, Chemistry, No. 7) is present; delirium may be present; the diplococcus may be found in the cerebrospinal fluid. 496 MEDICAL RECORD 5. Arteriosclerosis is a condition in which the walls of an artery, especially the intima, become hard, dry, and thickened. Etiology: Syphilis, alcoholism, gout, Bright' s disease, overeating, and excessive muscular exertion. It is most liable to occur in old age. 6. Symptoms of hemorrhage in typhoid fever: Sudden drop in the body temperature, dark red or tarry stools, collapse. Treatment: Absolute rest; elevate the foot of the bed: ice, morphine, and ergot have all been used with satisfac- tion. 7. The chief cause of locomotor ataxia is syphilis. Symptoms: Loss of coordination; characteristic and un- steady gait ; tendency to staeger when standing up with feet together and eyes closed ; sharp and paroxysmal pain, called crises: girdle sensation: loss of knee-jerk and other re- flexes; Argyll-Robertson pupil. 8. In chronic interstitial nephritis the urine is increased in quantity, is of low specific gravity, a few hyaline casts mav be present, albumin is present in small amount or is absent, and urea and salts are diminished. Circulation: Heart is generally hypertrophied and di- lated ; arteries are sclerosed and thickened ; pulse is hard and there is increased arterial tension. 9. Treatment of acute articular rheumatism: The pa- tient must lie in bed, between blankets, and in flannel ; the affected joints and limbs must further be covered with warm flannel or cotton wool. Sodium salicylate or oil of wintergreen must be administered, and oil of gaultheria may also be applied locally to the affected parts. Acetate and citrate of potassium are also useful. For the pain. Dover's powder, or phenacetin, or morphine may be neces- sary. A cold bath is probably the best thing for the high fever. The diet should be liquid, and simple but nourish- ing; milk being the best. 10. Prescription for local treatment of erysipelas: B. Ichthyol, -gr^jxxxv. Resorcin. 3ss. Unguenti hydrarevri, 3iv. Adipis lanae hydrosi, 3v. Misce. Signa : Apply freely, and cover with lint. SURGERY. 1. Paronychia is a cellulitis beginning at the end or side of the finger and involving the parts around and below the nail. The pus organisms enter through a puncture, an abrasion, or an ulcerated hang-nail. Treatment is free and early incision, drainage, antiseptic dressings, tonics, and stimulants. The nail may or may not have to be re- moved. 497 MEDICAL RECORD. 2. Osteomyelitis of Tibia. Pathological Changes: "The area of the medulla affected becomes hyperemic ; exudation occurs in the cancellous spaces, Haversian canals, and under the periosteum. Pus soon forms in these three situa- tions. If the disease begins in the superficial part of the bone, the pus may only be subperiosteal, the deeper part of the bone escaping, though large areas of the superficial portion may die from the combined action of (i) stripping up of the periosteum by the pus, (2) strangulation of the vessels in the bone by the pressure of the exudation, and (3) the toxic action of the bacterial products. . . . When the disease begins in the deeper layers of the bone, the pus may reach the periosteum, or extend along the medullary cavity, so that the veins become filled with septic thrombus, which may be disintegrated and carried off as septic emboli (pyemia). There is profound toxemia, and necrosis of the whole diaphysis may occur. ... If the infection is mild, a chronic abscess may be formed in the cancellous tissue. The usual course of an acute case, if a patient survives, is that there is some necrosis of the shaft of the bone. The abscess bursts externally, and there are numerous openings in the skin leading through open- ings (cloacae) in the periosteum and involucrum down to the sequestrum. The sequestrum becomes loose in six weeks to six months." (From Aids to Surgery.) Treatment is immediate incision down through the peri- osteum ; the surface of the bone must be opened with gouge or chisel, pus evacuated, and drainage instituted; irrigation with hot bichloride solution and packing with gauze. The medulla of the bone must be freely exposed, and any sup- purating material removed. Constitutional treatment and rest are, of course, indicated. 3. "Many operations are practised, but Bassini's is the most useful. An incision 2^/2 inches long is made over the inguinal canal, exposing the structures of the cord and the external oblique. The external oblique fibers are split from the apex of the external ring to expose the canal. The sac is found, opened, emptied of its contents, and isolated from the structures of the cord up to the internal ring. If the hernia is irreducible, the intestine is freed and returned to the abdomen, omentum being ligatured and removed. The neck of the sac is then transfixed and tied with silk, and the fundus removed. The stump returns to the abdomen, three or four stitches are then passed through the conjoined tendon and arched fibers of the internal oblique and transversalis muscles above, and the deep part of Poupart's ligament below. These are tied behind the cord. The external oblique is then sutured in front of the cord, leaving just sufficient opening for it to pass through without pressure. The skin is then closed by 498 MEDICAL RECORD. a continuous stitch. The patient should be kept in bed for three weeks, and should not exert himself for at least six weeks. If the wound has suppurated, or if the case is one in which the abdominal muscles are weak, it -is advisable that a light truss should be worn afterwards for six months/' (From Aids to Surgery.) 4. For operation, see any text-book on Surgery. 5. Stop the administration of further chloroform, open the patient's mouth, draw out his tongue, start artificial respiration. Mouth and throat must be sponged out if necessary; a hypodermic injection of strychnine, ether or brandy may be given, but the artificial respiration must not be stopped. 6. To prepare the hands: The hands and forearms should be rubbed with spirits of turpentine; then scrubbed with castile soap, hot water, and a sterilized nail brush ; this should continue for several minutes; thorough rinsing must follow; the hands are then to be soaked for two minutes in a 1 : 1,000 bichloride of mercury solution. Care must then be taken lest the hands touch anything that is not sterile. 7. Abscess of the liver may occur after purulent appen- dicitis, owing to the possibility of infection from the appendix reaching the liver through the portal vein, or through the lymphatics. 8. The joints both above and below a fracture should always be immobilized. 9. " CHANCRE. First lesion of a _ constitu- tional disease, viz., syphi- lis. Due to syphilitic infection. Generally a venereal infec- tion. May occur anywhere on the body. Period of incubation never so short as ten days. Generally single. Not autoinoculable. Secretion slight. Slightly or not at all painful. As a rule only occurs once in any patient. Buboes are painless and sel- dom suppurate. CHANCROID. A local disease. Due to contact with secre tion from chancroid. Always a venereal infection. Nearly always on genitals. Period of incubation always less than ten days (gen- erally about three). Generally multiple. Autoinoculable. Secretion profuse and puru- lent. Generally painful. May reoccur in same pa- tient. Buboes are painful and usually suppurate. 499 MEDICAL RECORD. The period of incubation of chancre is anywhere from two to six weeks after infection; of chancroid is about two to five days after infection. 10. Phelps' Operation. Step. i. — Render limb bloodless by elevation and apply tourniquet. Place the foot, with outer side downwards, on a sand-bag. Have the heel held firmly. Grasp the distal portion of the foot and make the plaster tissues tense. Step 2. — On the inner side of the foot make an incision beginning directly in front of the malleolus and ending one-fourth of the distance across the sole of the foot. Divide all resisting structures, penetrat- ing to the bone if necessary. Step 3. — By manipulation complete the overcorrection of the varus. Step 4. — Correct the equinus by achillotomy. Step 5. — Pack the wound with iodoform gauze. Dress. Immobilize, in a position of overcorrection, by a plaster-of-Paris bandage, which reaches well up the calf. While the plaster is hardening, hold the foot in its new position by means of a flat board laid against the sole. Step 6. — Remove the tourniquet. Elevate the limb for twenty-four hours. 11. The Wasserman reaction is used for the diagnosis of syphilis. STATE BOARD EXAMINATION QUESTIONS. Medical Examining Board of North Dakota. anatomy. 1. Name the divisions of the ear and the contents of the tympanum. 2. Describe the male urethra. 3. What nerves form the brachial plexus? 4. Name all the muscles moving the arm. 5. Describe the elbow joint. 6. Describe the popliteal space; gave its boundaries and contents. 7. Describe the axillary artery. 8. With what bones does the fibula articulate? HISTOLOGY. 1. Give the distribution and structure of nonstriated muscle. 2. Describe the lining of the stomach. 3. Give the histology of the gall-bladder and ducts. 4. Name and describe the different kinds of epithelium. 5. Give the histology of a medium-sized artery. PHYSIOLOGY. 1. Describe the function of the heart. 500 MEDICAL RECORD. 2. Define: (a) proteids; (b) carbohydrates, and name an example of each. 3. Describe the process of digestion of an egg sandwich. 4. Describe carefully normal urine. 5. What structures possess the function of : (a) elimi- nation; (b) secretion? MATERIA MEDICA. 1. What is meant by incompatibility? Distinguish be- tween chemical and physiological incompatibility. 2. Define diuretic and diaphoretic, and name three drugs belonging to each class. 3. What is an anthelmintic. Give names of three. 4. Give physiological action of strophanthus, the dose of the tincture, and indications for its use. 5. Give dose of the following drugs: (i)*morphine sul- phate; (2) atropine sulphate; (3) apomorphine hydro- chlorate; (4) Dover's powder; (5) phenacetin; (6) tinc- ture of opium ; (7) oleum tiglii ; (8) oleum terebinthinae ; (9) pilocarpine nitrate. CHEMISTRY AND TOXICOLOGY. 1. Describe a chemical test for detection of organic im- purities in drinking water. 2. Give formula and explain difference between corro- sive mercuric chloride and mild mercurous chloride of the pharmacopoeia. 3. Give a chemical test for hydrochloric acid in stomach contents. 4. Describe methyl and ethyl alcohol. 5. AgN0 3 + NaCl=? 6. What is an antidote for poisoning by corrosive sub- limate ? 7. Give symptoms and treatment of arsenical poisoning. 8. Differentiate between alcoholic and opium coma. PATHOLOGY. 1. (a) What are the causes of fever? (b) What are the effects of fever? 2. (a) Mention all the pathological conditions which may produce hemoptysis, (b) The same of hematemesis. 3. Give the pathology of tubercle. 4. Explain the propagation of tapeworm. 5. Mention the different varieties of goiter and give their pathological differences. PRACTICE. 1. How diagnose typhoid fever? 2. Give differential diagnosis between smallpox and chickenpox. 501 MEDICAL RECORD 3. Discuss the treatment of pulmonary tuberculosis among the poor. 4. Give treatment for the two most common of the valvular heart lesions. 5. Give treatment for the different pleural effusions. 6. Discuss prognoses in cerebral embolism and cerebral hemorrhage. 7. Write a short article on epilepsy. 8. Discuss intestinal neurosis. 9. How would you manage a case of nervous prostration in a very poor family? 10. What are the comparative urinary findings in the first stages of chronic parenchymatous and chronic inter- stitial nephritis? NERVOUS DISEASES. 1. Give diagnosis and treatment of infantile paralysis. 2. Diagnosis of cerebral tumor. 3. Name five reflexes and manner of detecting them. 4. Diagnosis and treatment of chorea. 5. Diagnosis and treatment of tuberculous meningitis. OBSTETRICS. 1. Diagnosis of pregnancy at three months; at six months, and number of days in which it terminates at full term. 2. Name and describe the various head presentations. 3. How would you proceed in a case of placenta previa? 4. What are the dangers of prolapsus of the cord, and how would you treat it? 5. Give the causes for asphyxiation of the infant, and your method of overcoming it. 6. How treat a case of puerperal sepsis? DISEASES OF WOMEN AND CHILDREN. 1. Give cause, symptoms, diagnosis, prognosis, and path- ology of pyosalpinx. 2. Mention some of the causes of sterility in women, and outline treatment. 3. Differentiate between ^ tubal pregnancy, pyosalpinx, ovarian cyst, and appendicitis. 4. Describe the uterus and its changes during pregnancy. 5. Give causes and treatment of rectovaginal fistula. 6. Describe and give cause for "Hutchinson's teeth." 7. In what class of subjects are the cells sensitized to diphtheria antitoxin, making its administration almost sure to cause sudden death? 8. Give symptoms, diagnosis, and treatment of intus- susception in a boy twelve years of age. S02 MEDICAL RECORD. 9. Give symptoms, pathology, and treatment of Pott's disease of the spine. 10. How do you make a positive diagnosis of diphtheria? SURGERY. 1. Give diagnosis, prognosis, and treatment of fracture at the neck of femur. 2. Give indications for trachelorrhaphy. Describe the operation. 3. Give causes and treatment of retention of urine. 4. How do you treat punctured wounds? 5. How do you select and administer a general anes- thetic? 6. Give diagnosis and treatment of strangulated in- guinal hernia. 7. Give diagnosis and surgical treatment of gall-stones ; describe the operation in detail. 8. Give diagnosis and treatment of the different disloca- tions of the shoulder. 9. What is a Colles fracture? How do you dress it? EYE AND EAR. i. Cause, symptoms, and treatment of ophthalmia neon- atorum. 2. Causes, symptoms, and treatment of iritis. 3. Causes, symptoms, and treatment of glaucoma. 4. Treatment of blepharitis marginalis. 5. Define astigmatism, myopia, hypermetropia, diplopia, and chalazion. 6. Treatment of acute otitis media. 7. Symptoms and treatment of acute mastoiditis. 8. How do you remove foreign bodies from the ear? 9. How relieve pain in furunculosis of the auditory canal? 10. Describe fully effect of nasopharyngeal adenoids upon the ear and its function. MEDICAL JURISPRUDENCE. i. What is a malingerer, and how would you set about to discover whether a patient were feigning sickness or not? 2. Within what period after the treatment complained of can a patient maintain an action for malpractice against a physician or surgeon in this State? 3. (a) Does the law of this State fix a schedule of fees limiting charges of physicians and surgeons either for traveling to attend patients professionally, or for pro- fessional services rendered, and if so, what is it? (b) What, if any, preference is given by the statutes of this State to physicians and surgeons in the matter of collec- 503 MEDICAL RECORD. tion of their fees for professional services rendered tneir patients? 4. Does the law of this State fix any definite minimum period of gestation in civil or criminal matters in the courts of the State involving the determination of pater- nity, and if so, what is it? 5. A duly licensed physician and surgeon in this State is called upon by a female who complains of symptoms which indicate ovarian trouble. The doctor diagnoses the case as one of infected cyst of the ovary, and advises that an immediate operation is necessary. The patient consents, and the doctor operates and finds the trouble to be that diagnosed. He successfully removes the cyst, but in doing so accidentally incised the intestine. While he undertook to repair the unnecessary incision in the intestines, he nevertheless failed, and the woman died. Is he liable to action for malpractice, and if so, why? 6. Has the State Board of Medical Examiners power, under the laws of this State, to reinstate a physician and surgeon in good standing and reissue a license to him to practise medicine and surgery in the State, after their former license to him has been revoked for the commission of a felony of which he has been convicted in this State? PREVENTIVE MEDICINE. i. If treating a case of typhoid in the country, give your instructions in full to family regarding the prevention of spread of the disease. 2. Name all the ways you know in which tuberculosis may be communicated, and what would be your method of preventing the same? 3. Give your method of fumigating for smallpox. 4. Describe the different methods of obtaining a pure water supply for a prairie town of 2,500. 5. Name all the diseases you know of that need quaran- tine and length of time required in each case. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Medical Examining Board of North Dakota. anatomy. 1. External ear, middle ear, or tympanum; and internal ear or labyrinth. For contents of tympanum see Cunning- ham's "Anatomy" (1909), page 74$; or Gray's "Anatomy" (1908), page 1 160. 2. See Cunningham's "Anatomy" (1909), page 1177; or Gray's "Anatomy" (1908), page 1450. 504 MEDICAL RECORD. 3. The anterior divisions of the fifth, sixth, seventh, and eighth cervical, and the first dorsal nerve. 4. See Cunningham's "Anatomy" (1909), page 331; or Gray's "Anatomy" (1908), page 308. 5. See Cunningham's "Anatomy" (1909), page 279; or Gray's "Anatomy" (1908), page 310. 6. See Gray's "Anatomy" (1908), page 707. 7. See Cunningham's "Anatomy" (1909), page 827; or Gray's "Anatomy" (1908), page 649. 8. Tibia and astragalus. HISTOLOGY. i. In non-striated muscle "the individual fibers are short, narrow, and spindle-shaped. Each is usually 25 to 200 microns in length, and 5 to 70 microns in breadth. No sarcolemma is present, and striations are absent. In each fiber there is but one nucleus, which is long, slender, darkly staining, and centrally located. This is not seen in all cross-sections, but when present shows as a small, dark dot. These fibers vary in length from 25 to 200 microns, ordinarily; in diameter they average about 5 microns. The fibers are arranged in bundles, but instead of forming masses like muscles the bundles are arranged into layers, which extend circularly and longitudinally in the hollow viscera. Capillaries exist between the fibers. The nerves are chiefly of the sympathetic variety. Distri- bution: Involuntary muscles are found in the alimentary tract from the middle third of the esophagus to the anus, in the ducts of glands, in the trachea and bronchial tubes, the internal urinary and genital systems, circulatory (ex- cept the heart) and lymphatic systems, and the capsules of some organs." — (From Radasch's Compend.) 2. See Cunningham's "Anatomy" (1909), page 1059; or Gray's "Anatomy" (1908), page 1283. 3. See Cunningham's "Anatomy" (1909), page 11 19; or Gray's "Anatomy" (1908), page 1352. 4. Kinds of Epithelium, (i) Pavement or Squamous: A single layer of flat, nucleated cells, cemented together at their edges. (2) Stratified: In layers of cells that are unlike in form. (3) Columnar: Tall, cylindrical cells ar- ranged in a single layer. (4) Cuboidal: Similar to columnar, but the cells are shorter. (5) Ciliated: Colum- nar cells with hair-like processes (cilia) on their free surface. (6) Goblet: Cylindrical cells distended with mucin. (7) Transitional: When the cells are neither ar- ranged in a single layer like squamous, nor yet in many superimposed layers like stratified, but in two or three layers. 5. See Cunningham's "Anatomy" (1909), page 781; or Gray's "Anatomy" (1908), page 587. 505 MEDICAL RECORD PHYSIOLOGY. i. The function of the heart is to propel the blood through the blood-vessels. The cardiac cycle includes all the changes which occur between the commencement of one heart-beat and the commencement of the next; it consists of the alternate contractions (or systole) and relaxations (or diastole) of the auricles and ventricles of the heart. The contraction of the two auricles takes place simultane- ously and is followed by the simultaneous contraction of the two ventricles; then follows a period during which the whole heart is in a state of diastole. The cycle then be- gins again with the auricular systole. 2. (a) Proteids are highly complex compounds of un- known constitution, whose molecule contains carbon, hydro- gen, oxygen, nitrogen, and sulphur, and sometimes other elements, and occurring in nearly all parts of the body. Example: Albumin. (b) Carbohydrates are compounds consisting of carbon, hydrogen, and oxygen, the last two being in the proportion to form water; most of the simple carbohydrates are aldehydes or ketones. Example: Sugar. 3. The egg consists of : Proteid and fat. Bread consists of carbohydrate, proteids, and fat. Butter consists of fat and proteids. Of these, the proteids are digested in the stomach by the pepsin of the gastric juice, and in the small intestine by the trypsin of the pancreatic juice. The carbohydrates are digested (slightly) by the ptyalin of the saliva and mainly in the small intestine by the amylopsin of the pancreatic juice. The fat is digested in the small intestine by the steapsin of the pancreatic juice. 4. Normal urine is a yellowish fluid secreted by the kid- neys to the amount of about 1200-1500 c.c. daily; specific gravity, about 1015 to 1025; acid reaction (due to acid sodium phosphate) ; it has a characteristic odor and a salty taste. Its normal constituents are : Water, urea, uric acid, urates, hippuric acid, kreatin, kreatinin, xanthin, hypoxanthin; sulphates, chlorides, and phosphates of so- dium and potassium; phosphates of magnesium and cal- cium ; nitrogen, and carbon dioxide. 5. (a) Structures of elimination: Lungs, kidneys, in- testines, skin, (b) Structures of secretion: Serous and synovial membranes ; mucous membranes (glands in mouth, stomach, and intestines); salivary glands and pancreas; liver ; mammary glands ; lacrimal glands ; kidneys ; skin ; testes. MATERIA MEDIC A. i. By incompatibility is understood the simultaneous administration or combination of substances not suitable for such combination. Physiological incompatibility occurs 506 MEDICAL RECORD. when two remedies are thus administered which offset each other's physiological action, so that they are inert. Chem- ical incompatibility occurs when remedies which are mixed together undergo chemical decomposition or explosion. 2. Diuretics are agents which promote the secretion of urine. Examples : water, alcohol, potassium acetate. Diaphoretics are agents which promote the secretion of sweat and increase the activity of the skin. Examples : alcohol, Dover's powder, Turkish bath. 3. Anthelmintics are agents which kill or expel worms. Examples : Oleoresina aspidii, gr. xxx ; Pelletierine tan- nate, gr. x; santonin, gr. j ; pumpkin (pepo) seeds, 3J- 4. Strophant Juts causes stiffness of limbs and loss of voluntary movement ; it paralyzes the muscles ; it stimulates the heart, prolongs diastole, increases the force of the cardiac contractions, lowers and regulates cardiac rhythm, and raises blood pressure; it is a diuretic. The dose of the tincture is Tf#viij. It is used like digitalis in mitral diseases, aortic stenosis, tricuspid diseases, cardiac dilata- tion, exophthalmic goiter, chronic alcoholism, nephritis, palpitation of the heart. 5. Dose of: (1) Morphine sulphate, is gr. %. (2) Atropine sulphate, gr. 1/160. (3) Apomorphine hydro- chloride, gr. 1/10. (4) Dover's powder, gr. vijss. (5) Phenacetin, gr. vijss. (6) Tincture of opium, TTgviij. (7) Oleum tiglii, Ti^j. (8) Oleum terebinthinoe rectificatum, r$xv. (9) Pilocarpine nitrate, gr. 1/5. CHEMISTRY AND TOXICOLOGY. 1. Organic matter in drinking water can ordinarily be detected by the addition of solution of potassium perman- ganate, which becomes rapidly discolored in the presence of the former. 2. Corrosive mercuric chloride, HgCl 2 . Corrosive subli- mate is heavy, white, and crystalline ; it has a strong, acrid, styptic taste, and is soluble in water, in alcohol, and in ether ; it is decomposed by exposure to light. Mild mercurous chloride, Hg 2 Cl 2 , calomel, is a heavy, white powder, amorphous, tasteless, and odorless ; it is insoluble in cold water and in alcohol, and very slightly soluble in boiling water ; when exposed to the light it be- comes discolored (first yellow, then gray) and partially decomposed ; it sublimes without fusing. 3. Test for free hydrochloric acid in the gastric juice: The best is probably the Dimethylamido-azobenzol test ; the reagent is used in 0.5 per cent, alcoholic solution, of which one or two drops are added to a like amount of the filtered gastric juice. If free HC1 is present, the yellow solution turns red. 4. Methyl alcohol is a colorless liquid having an ethereal 507 MEDICAL RECORD. and alcoholic odor and a sharp, burning taste ; burns with a pale flame, giving less heat than that of ethylic alcohol; mixes with water, alcohol, and ether in all proportions; is a good solvent of resinous substances, and also dissolves sulphur, phosphorus, potash, and soda. Ethyl alcohol is a thin, colorless, transparent liquid hav- ing a spirituous odor and a sharp, burning taste. It mixes with water in all proportions, the union being attended by elevation in temperature and contraction in volume (after cooling to the original temperature). It also at- tracts moisture from the air to such a degree that abso- lute alcohol only remains such for a very short time after its preparation. 5. AgNOs + NaCl = AgCl + NaN0 3 . 6. White of egg in moderate quantity, followed by an emetic. 7. The symptoms of acute arsenical poisoning: "In acute cases the symptoms usually begin in from 20 to 45 minutes. Nausea and faintness. Violent, burning pain in the stom- ach, which becomes more and more intense, and increases on pressure. Persisting and distressing vomiting of mat- ters, sometimes brown or gray, or streaked with blood, or green. Purging. More or less severe cramps in the lower extremities."— (Witthaus' Essentials of Chemistry.) The chemical antidote is freshly prepared ferric hydroxide. The ferric hydroxide changes the arsenic into ferrous arse- nate, which is nonpoisonous. 8. In opium coma: The pupils are contracted, the res- piration is slow and full, the skin warmer than in alcohol poisoning, the face suffused, and the pulse slow and full. In alcohol coma: The pupils are not contracted, the res- piration approaches the normal, the skin is cool and some- times moist, the face may be pallid, and the pulse is rapid. PATHOLOGY. 1. (a) Causes of fever: Disturbance of the heat-regulat- ing centers, either directly or by toxic substances circulat- ing in the blood. These latter may come from bacteria, or may be due to disordered metabolism, or to chemical or mechanical injury of the tissues. (b) Effects of fever: Loss of appetite, thirst, emaciation, disturbance of function, the alkalinity of the blood is les- sened; degenerative changes such as cloudy swelling, fatty degeneration, and coagulation necrosis may occur in the tissues, particularly in the heart, liver, kidneys, and muscles. 2. (a) The causes of Hemoptysis: Traumatism; certain organic diseases of the lung, especially tuberculosis, lobar pneumonia, bronchiectasis, gangrene, infarct, and can- cer. Passive congestion, the result of heart disease, espe- cially mitral lesions; rupture of aortic aneurysm; diseases 508 MEDICAL RECORD profoundly affecting the blood, such as purpura, hemophilia, scurvy, and leukemia ; ulcers, traumatic, syphilitic, or ma- lignant of the trachea or larynx; and vicarious menstrua- tion (very rare). (b) The causes of Hemat erne sis: Traumatism; gastric ulcer; gastric cancer; venous engorgement of the stomach following cirrhosis of the liver, primary splenomegaly, or chronic heart disease ; acute gastritis ; blood dyscrasia, as in scurvy, purpura, severe infections, and grave anemias; rupture of aneurysm ; swallowing of blood from nose, mouth, or throat; vicarious menstruation; hysteria. — (From Stevens' Practice.) 3. See French's "Practice" (1907), page 342; or Osier's "Practice" (1909), page 295. 4. The cycle of the adult tapeworm is as follows : "From each individual segment, which is possessed of a complete reproductive system, great numbers of eggs are discharged. The latter are expelled from the intestine with the feces, and some of them may eventually enter the digestive tract of swine or cattle through the food or water. In the intestine the embryos become liberated from the eggs, and they then make their way in large numbers to the muscular tissue, brain, liver, and other parts, where they come to rest and develop as bladder worms. The living animal shows nothing in its appearance to indicate the presence of the parasite, excepting when the cyst can be seen in the under side of the tongue or between the tongue and the lower jaw. If now the animal is slaughtered and the meat eaten raw or imperfectly cooked, the cysticercus is freed from its enveloping capsule and proceeds to develop into an adult tapeworm, and the cycle is complete." — (From Harrington's Hygiene.) 5. See French's "Practice" (1907), pages 546 and 548; or Osier's "Practice" (1909), pages 763 and 765. PRACTICE. i. See French's "Practice" (1907), page 101 ; or Osier's "Practice" (1909), page 93. 2. (1) Very young children are attacked with varicella, whereas variola usually shows itself in adults. (2) Vac- cinated children readily take varicella ; not so variola, even in the modified form. (3) Children who have had varicella may contract variola, even soon afterwards; or the two diseases may coexist. (4) Varicella is noninoculable, whereas variola is notoriously so. (5) The eruption of varicella appears in 24 hours ; that of variola not till the third day. (6) The febrile symptoms continue after the eruption appears in varicella; those of variola subside. (7) In varicella the spots come out in excessive crops; this is never seen in variola. (8) The spots in varicella are 509 MEDICAL RECORD. unilocular, and collapse on being punctured; the spots in variola are multilobular, and do not collapse on being punctured. (9) In varicella the eruption is very irregular, and appears over the body generally; in variola it appears in groups of threes and fives, and is always seen on the limbs. (10) The papule in varicella is soft, and disappears on stretching the skin; in variola it is hard and snotty, and does not disappear on stretching the skin. — (From J. W. Moore's work on Variola and Varicella.) 3. See French's ."Practice" (1907), page 391; or Osier's "Practice" (1909), page 352. 4. See French's "Practice" (1907), page 592; or Osier's "Practice" (1909), page 816. 5. See French's "Practice" (1907), page 699; or Osier's "Practice" (1909), page 653. 6. See French's "Practice" (1907), pages 1076, 1079, and 1082; or Osier's "Practice" (1909), pages 976 and 978, 7. See French's "Practice" (1907), page 1125; or Osier's "Practice" (1909), page 1058. 8. Intestinal neurosis includes any disturbance of the motor, sensory, or secretory functions of the intestine, pro- vided such disturbance is of nervous causation. (1) Motor includes : Paralysis of the intestines, disorders of defeca- tion, constipation, intestinal obstruction, increased peristal- sis, spasm, colic, tenesmus. (2) Sensory includes: Pain, colic, enteralgia. (3) Secretory includes: Nervous diar- rhea, mucous colitis. For details of these see Index to French's or Osier's "Practice." 9. See French's "Practice" (1907), page 1153; or Osier's "Practice" (1909), page 1092. 10. In chronic parenchymatous nephritis: The urine is slightly diminished, turbid, has abundance of albumin, generally some blood, abundance of sediment, blood cor- puscles, casts (especially fatty), diminished urea. In chronic interstitial nephritis: The urine is increased in quantity, pale, clear, of low specific gravity, little or no albumin, scanty sediment, few casts, diminished urea. NERVOUS DISEASES. 1. See French's "Practice" (1907), page 1084; or Osier's "Practice" (1909), page 916. 2. See French's "Practice" (1907), page 1104; or Osier's "Practice" (1909), page 9QI- FIVE REFLEXES. Knee jerk. MODE OF EXCITA- TION. By striking patel- lar tendon with Sio NATURE OF RESULT. A single upward jerk of the leg MEDICAL RECORD. FIVE REFLEXES. MODE OF EXCITA- NATURE OF TION. RESULT. edge of hand or and foot, slight with percussion or distinct. hammer, while leg hangs loose- ly over other leg, Ankle clonus With knee extend- A series of clonic ed or very slight- contractions a t ly flexed, by the ankle-joint, pressing quickly continuing as and firmly against long as the pres- anterior part of sure is main- sole of foot (so tained, and in- as to stretch calf- stantly ceasing muscles) and when it is re- then keeping up laxed. the pressure. Plantar reflex Tickling sole of Movements of foot. toes ; o f these and foot; or of these and leg. Gluteal reflex Irritation of skin Contraction of of buttock. glutei. Cremasteric reflex. Irritation of skin Drawing up of of upper and testicle. inner part of thigh. 4. See French's "Practice" (1909), 5. See French's "Practice" (1909), "Practice" (1907), page 1120; or Osier's page 1051. "Practice" (1907), page 350; or Osier's pages 302 and 926. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), page 190; or Hirst's "Obstetrics". (1909), page 204. 2. See Williams' "Obstetrics" (1909), page 206; or Hirst's "Obstetrics" (1909), page 395. 3. See Williams' "Obstetrics" (1909), page 815; or Hirst's "Obstetrics" (1909), page 577. 4. See Williams' "Obstetrics" (1909), page 843; or Hirst's "Obstetrics" (1909),. page 626. 5. See Williams' "Obstetrics" (1909), pages 844 and 846; or Hirst's "Obstetrics" (1909), page 939- 6. See Williams' "Obstetrics" (1909), page 883; or Hirst's "Obstetrics" (1909), page 737- DISEASES OF WOMEN AND CHILDREN. I. See Rose and Carless' "Surgery" (1908), page 1288. 5ii MEDICAL RECORD. 2. The most common causes of sterility in woman are : Gonorrhea, absence or errors in development of any part of the genital tract, malformations of genitals, fistulae, lacerations, obesity, alcoholism, pelvic nflammation, dys- pareunia, inflammation of uterus, tubes, or ovaries, elon- gated cervix. Treatment consists in removing the cause, if possible; curettage has been recommended; in the pres- ence of developmental errors little or nothing can be done ; atresia of cervix can be treated by dilatation; if the uterus is misplaced it must be replaced. 3. In extrauterine pregnancy, there will be signs of early pregnancy, hypogastric or inguinal pains, probable history of a previous sterility, probable expulsion of decidual mem- brane or shreds, softening of the cervix, enlargement of the uterus, presence of a distended tube, contractions of the wall of the gestation sac; if rupture occurs, there will be sudden, excruciating pains over the lower abdomen and on the affected side, shock, collapse, and symptoms of internal hemorrhage. In appendicitis, there are no signs of pregnancy; there are sudden pain and tenderness in the right iliac fossa, rigidity of right rectus muscle, fever, nausea, vomiting, constipation, no history of menstrual irregularities. In pyosalpinx the tubes are inflamed usually secondary to inflammation of uterus or to infection (either gonorrheal or puerperal), backache, pain in lower abdomen, history of menstrual irregularity, leucorrhea, tube is enlarged and tender. In ovarian cyst, no signs of pregnancy, the tumor may grow to enormous size, fluc- tuation generally distinct, emaciation, not painful, facies ovariana. 4. In the nulliparous adult the uterus is about three inches long, about two inches wide at the upper part, and about one inch thick. The uterus lies between the rectum behind and the bladder in front; it is below the abdominal cavity and above the vagina. Its position is one of slight anteflexion, with its long axis at right angles to the long axis of the vagina. The anterior surface of its body rests on the bladder, and the cervix points backward toward the coccyx. The uterus is not fixed, but moves freely within certain limits. It is held in place by ligaments — broad liga- ments, round ligaments, vesicouterine and rectouterine. During pregnancy the uterus increases in size (from 3 to 12 inches in length; from iy 2 to 9 inches in breadth), in weight (from about one ounce to two pounds, not includ- ing its contents). The cavity is enlarged over 500 times. All the tissues, muscles, ligaments, arteries, veins, lymph- atics, and nerves become tremendously hypertrophied. The uterus also changes its position; at first it drops, later it gradually rises, till just before labor (when it again drops). 512 MEDICAL RECORD. 5. Rectovaginal Fistula. Causes: Protracted labor, ul- ceration due to pessaries or foreign bodies, carcinoma, syphilis or tuberculosis, pelvic abscess; it may be con- genital. Treatment: A plastic operation is necessary. The edges of the fistula are denuded and then approximated with sutures, the same as for vesicovaginal fistula. 6. See French's "Practice" (1907), page 424; or Osier's "Practice" (1009), page 271. 7. See Osier's "Practice" (1909), page 205. 8. See French's "Practice" (1907), page 804; or Osier's ••Practice" (1909), page 525. 9. See Rose and Carless' "Surgery" (1908), page 718; or Da Costa's "Surgery" (1908), page 748. 10. By finding the Klebs-Loeffler bacilli. SURGERY. 1. See Rose and Carless' "Surgery" (1908), page 535 J or Da Costa's "Surgery" (1908), page 512. 2. Trachelorrhaphy. Indications: Laceration of cer- vix uteri; particularly when followed by subinvolution of uterus, by eversion and hypertrophy of cervix, by infection, by Xabothian-cysts, by menorrhagia, leucorrhea, backache, and reflex nervous disturbances. Operation: "The patient is anesthetized and placed in the lithotomy position, and the cervix well exposed by a speculum. The vagina is thoroughly disinfected by douch- ing and swabbing, and dilatation and curetting are then carried out when necessary. After this the anterior lip of the cervix is seized with a volsella, and the reversible ten- acula forceps introduced exactly in the middle line and the points separated. The volsella is then removed. By means of scalpel and forceps two flaps are now dissected off the exposed surface, taking care to leave a narrow strip of mucous membrane in the middle line, which will form the lining for the new cervical canal when the lips are approx- imated. While the surfaces are being vivified there is usually free oozing; this is useful, as it serves to deplete the cervix and diminish its volume. In many cases before operation the bulk}', everted lips look as if they could not come together, yet, after depletion brought about by dissec- tion, they can be approximated with ease. When the flaps have been dissected off, the tenacula forceps are removed, the lips of the cervix are allowed to fall together, and the forceps are then reapplied in such a way as to hold them in apposition. Care must be taken to secure the cervix in the middle line. A curved needle is used to introduce the sutures ; the best material is silkworm gut, and, if secured by means of shot and coil, their subsequent removal is greatly facilitated. Three or four sutures should be placed on each side, and those nearest the middle line should be 513 MEDICAL RECORD about one centimeter apart. The tenacula forceps are now removed and a sound is passed into the uterus, to make sure that the cervical canal is free. The parts are then carefully dried, and the vagina lightly packed with iodo- form gauze." 3. See Rose and Carless' "Surgery" (1908), pages 1202 and 1244; or Da Costa's "Surgery" (1908), page 1125. 4. See Rose and Carless' "Surgery" (1908), page 238; or Da Costa's "Surgery" (1908), page 252. 5. See Rose and Carless' "Surgery" (1908), pages 1321 and 1324; or Da Costa's "Surgery" (1908), page 1025. 6. See Rose and Carless' "Surgery" (1908), pages 1100 and 1 103; or Da Costa's "Surgery" (1908), page 992. 7. See Rose and Carless' "Surgery" (1908), pages 1058 and 1061 ; or Da Costa's "Surgery" (1908), pages 891 and 894. 8. See Rose and Carless' "Surgery" (1908), page 619; or Da Costa's "Surgery" (1908), page 587. 9. See Rose and Carless' "Surgery" (1908), pages 521 and 525; or Da Costa's "Surgery" (1908), pages 505 and 508. * EYE AND EAR. i. Ophthalmia neonatorum. Causes: The gonococcus or some other pyogenic microorganism; .the secretions of the mother contain the infecting agent, and transmission may occur directly during parturition, or indirectly by the fingers of physician or nurse, cloths, instruments, etc. Symptoms: Swollen eyelids, with copious purulent dis- charge; ulceration of the cornea may ensue. Prophylaxis: Whenever there is the possiblity of infection, or in every case, wash the eyelids of the newborn child with clean warm water, and drop on the cornea of each eye one drop of a 1 per cent, solution of nitrate of silver, immediately after birth. Treatment: Wash the eyes carefully every half hour with a saturated solution of boric acid ; pus must not be allowed to accumulate. Two drops of 2 per cent, solution of nitrate of silver must also be dropped onto the cornea every night and morning. The eyes must be cov- ered with a light, cold, wet compress. The patient must be isolated, and all cloths and compresses used must be burnt. 2. Iritis. Causes: Syphilis, rheumatism, gonorrhea, gout, diabetes, leprosy, scrofula, tuberculosis, injury, trans- mission from the other eye. Symptoms: Pain, photophobia, small pupil, ciliary congestion, discoloration of iris, exudate in anterior chamber. Treatment: Casual, abstraction of blood from temples, atropine, diaphoresis, shielding the eye from light. 3. Glaucoma. Causes: Increase of contents of eye, hypersecretion, retentfon, old age, gout, rheumatism, ne- 514 MEDICAL RECORD. phritis. Symptoms: Visual disturbances, increased ocular tension, hazy and anesthetic cornea, sluggish and dilated pupil, shallow anterior chamber, ciliary neuralgia, cupping of optic disc, blindness. Treatment consists first in the local instillation of mi- otics, such as eserin or pilocarpin, to contract the pupil, and massage of the eyeball. Mydriatics are distinctly contra- indicated. The operative treatment includes paracentesis, iridectomy, sclerotomy, and incision of the ligamentum pectinatum. 4. Treatment of blepharitis marginalis: Remove cause, if possible; remove scales, and keep edges of lids clean and fresh, warm water or w^eak boric acid solution, or bichlor- ide of mercury 1:5,000; massage; silver nitrate (2 per cent.) on ulcers; epilation of distorted cilia; treat con- junctival or corneal disease. 5. Astigmatism is a condition in which, owng to a greater curvature of the eye in one meridian than in others, the refractive power of the eye varies. v Myopia is a condition in which the anteroposterior axis of the eye is abnormally long, and parallel rays are focused in front of the retina. Hypermetropia is a condition in which the anteropos- terior axis of the eye is abnormally short, and parallel rays are focused behind the retina. Diplopia is a condition in which an object seen appears double. Chalazion is a tumor in the eyelids, due to obstruction of the duct in a Meibomian gland. 6. Treatment of acute otitis media: "The treatment de- pends upon the symptoms, which are exceedingly variable. When the symptoms are those of middle ear-ache without great exudation, the treatment consists in the inflation of the Eustachian tube, alkaline spray to the post-nasal space, two to three drops of 8 per cent, solution of cocaine, dropped into the ear, and afterwards hermetically sealing the canal with small pledgets of cotton or inserting into the ear a few drops of the following, which will bring immediate results : I£ Chloralis camphorat., 5 parts. Glycerini, 30 " 01. amygdalae dulcis, 10 " As soon as the pain has disappeared the hyperemia and swelling of the Eustachian tube is quickly reduced by spraying the post-nasal space with alkaline solution, fol- lowed by the application of argentum nitrate eight grains to the ounce. The treatment of the external auditory canal and tympanum consists in dropping three to four drops of solution of zinc sulphate, eight grains to the ounce, into the ear and hermetically sealing with collodion. This is re- 515 MEDICAL RECORD. peated twice daily until all symptoms have passed away. If the pain and effusion into the ear is great, dry hot appli- cations, paracentesis, purging, antipyretics, and rest in bed are indicated. The disease runs its course in from three to ten days." 7. Acute Mastoiditis. Symptoms: Tenderness, pain, swelling and redness over the mastoid; bulging of the superior and posterior parts of the auditory canal; tem- perature variable, from normal up to about 104 F. Treat- ment: Hot water,, or cold water, or ice; leeches, purga- tives; light diet; acetanilid, incision, or mastoid operation. 8. Foreign bodies may be removed from ear: (1) In- sects, by warm water or chloroform oil; (2) by* syringing carefully; (3) wax may be removed by disintegrating it with hydrogen dioxide, followed by warm water irrigation. 9. Leeches; hot applications of hops or salt; cleaning with hydrogen peroxide; morphine; evacuate pus. 10. "The presence of adenoid tissue in the vault of the pharynx affects the ear in two ways. If the mass is large by direct pressure upon the Eustachian orifice the supply of air in the tympanic cavity may be disturbed. . . . Any slight increase in the volume of the mass will close the lumen of the tube, after which the intratympanic air is gradually absorbed by the blood which circulates through vessels in the walls of the cavity. With each act of swal- lowing, at which time the tube opens momentarily, the air is aspirated into the nasopharynx, the tube closing so quickly that the passage of air into the tympanum does not take place. In this manner a passive congestion of the mucous membrane of the middle ear is produced, a condi- tion which constitutes practically the first stage of an in- flammation, and, if long continued, results in permanent tissue changes. . . . The more important manner in which adenoid growths affect the organ of hearing is by the obstruction to the venous return current from the tympanum and labyrinth. The pharyngeal tonsil, in virtue of its presence, may exert sufficient pressure to partially obstruct the venous flow from the tympanic cavity. Any condition which affects, for a considerable period, the cir- culation within the middle ear will also cause a disturbance of the labyrinthine circulation from an alteration in the tension of the fluid contained. Such changes in the laby- rinth render it particularly susceptible to inflammation, either as the result of infecton or of mechanical irritation, the most fruitful source of the latter being the crowding inward of the ossicular chain by atmospheric pressure, when the tension of air within the tympanum is reduced. . . . There may also be a diminution of bone conduc- tion and a hyperesthetic condition of the auditory nerve." (From Dench's Diseases of the Eqr,) 516 MEDICAL RECORD MEDICAL JURISPRUDENCE. i. A malingerer is one who preterits to be ill when he is not. To aid in the discovery: Try to ascertain if there is any motive in such claim to be ill; make frequent and thorough examinations ; the examiner should be well read and expert ; instruments of precision and anesthetics should be used if necessary; malingerers are apt to overdo their part. 2. As a rule, there is no statute of limitations fixing time within which an action for malpractice must be brought ; but generally no such action will lie after a physi- cian has brought suit for his fee. 3. (a) No. (b) None. 4. No. 5. If carelessness or negligence is proved, he is liable ; but the matter will rest with the jury, and the verdict will depend largely on the "doctor on the other side," and the evidence of his "professional brethren." 6. No. PREVENTIVE MEDICINE. i. See French's "Practice" (1907), page 107; or Osier's "Practice" (1909), page 96. 2. See French's "Practice" (1907), pages 335 and 390; or Osier's "Practice" (1909), pages 287 and 351. 3. Fumigation should be by formaldehyde or sulphur. The best means of fumigating by formaldehyde gas are the following: (1) By Trillat's apparatus, which "allows the solution of formalin to flow in a fine stream through a copper coil heated to redness by a flame beneath, and the gas and vapor passing directly into the room. The apparatus may be operated outside of a room, and the amount of gas liberated depends directly upon the strength and quantity of the solution evaporated. (2) In Schering's method the solid paraform is heated in a receptacle over an alcohol lamp, and is especially valu- able in disinfecting small rooms, closets, etc. (3) The cheapest and most common form develops the gas directly by the oxidation of methyl alcohol, the vapors of the latter passing over or through tubes or coils of heated metal. The amount is uncertain and results indefinite." (Gould and Pyle's Cyclopedia of Medicine and Surgery.) Formaldehyde gas is formed by the oxidation of methyl alcohol. The action is quicker and more cer- tain if the temperature of the room is from 95 F. up to about 110 F. 4. Water supply from: (1) Rain water collected imme- diately as it falls as rain, dew, snow, etc. (2) Surface 517 MEDICAL RECORD. water collected in ponds, lakes, streams, etc., and in free contact with air. (3) Ground water, or subsoil water, de- rived from the rain water of the district, but which perco- lates through the subsoil, and so is not directly exposed to the atmosphere. (4) Deep or artesian water, which is separated from the ground water by one or more imper- meable layers. 5. Quarantinable diseases: Cholera, yellow fever, small- pox, plague, typhus, leprosy, diphtheria, scarlet fever, measles, mumps, chicken pox, erysipelas. For length of time, see index to these diseases in French's or Osier's "Practice." STATE BOARD EXAMINATION QUESTIONS. Ohio State Board of Medical Registration and Exami- nation. ANATOMY. 1. Enumerate the bones forming the orbit. 2. Give the nerve supply of the stomach. 3. Name the ligaments of the knee-joint. 4. Describe the lungs, briefly. 5. Describe histologically the structure of the kidney. 6. Give the arteries arising from the thoracic aorta in order, beginning at the heart. 7. Give the composition of bones and classify them. 8. Name the structures forming the larynx. 9. Describe the gastrocnemius muscle. 10. Describe the femur. PHYSIOLOGY. 1. What are some of the properties of protoplasm,? 2. Describe a neuron. 3. What is ameboid movement? 4. What are capillaries, and what function do they per- form ? 5. What forces contribute to the flow of blood through the veins? 6. What is reflex action? 7. In what does digestion and nutrition consist? 8. What function is performed by hydrochloric acid in digestion ? 9. What is the nutritive value of proteids? Name some articles of food containing a large proportion of proteid. 10. How should cow's milk be modified to resemble human milk? CHEMISTRY. 1. Milk: Give its composition. What impurities are most common and how would you detect them? 518 MEDICAL RECORD. 2. What is the chemical difference between acids having the termination ous and ic ? What names are given to com- pounds of such acids? 3. W^hat effect do alkalies have on gastric secretions? 4. Name and describe three general methods for the purification of water. 5. Explain where and how HC1 is made in the human body. 6. How are urates formed in the system, and how would you recognize them? 7. What is a calcium sulphide? Give its properties and uses. 8. What are the common properties of 'the mineral acids? 9. State the toxicological effect of carbolic acid and the therapeutic measures you would employ in a case of pois- oning. 10. What is meant by physiological antidotes? Name some you consider physiological for strychnine poisoning. MATERIA MEDICA AND THERAPEUTICS. i. Name and give the physical characteristics and prop- erties of the official salts and preparations of mercury com- monly employed. 2. Name the more important official preparations of digitalis. Under what conditions would you prescribe each? 3. Name the various serums whose place in medicine is recognized, and give uses of each. Also state modes of administration. 4. In what form should the iodides be administered? With what are they incompatible ? 5. Discuss the comparative value of ether and chloroform as general anesthetics. Give contraindications for each, and treatment for untoward effects. 6. In what particular conditions would you advise sug- gestive therapeutics? State briefly how you would manage a case requiring this treatment. 7. What symptoms follow the continued use of cocaine? How would you treat a cocaine habitue? 8. What indications would suggest digitalis or the nitrite group in cardiovascular disease? 9. Define alkaloids, give their common characteristics and physical properties. 10. When would you use galvanism and when the faradic current? PRACTICE OF MEDICINE. i. Name four diseases in which a leukocyte count of over 25,000 is probably present. 2. Differentiate a large ovarian cyst from hydronephrosis of the right kidney. 3. Differential diagnosis of lead colic. 519 MEDICAL RECORD. 4. Name the cardinal symptoms of aortic stenosis. 5. How would you treat bronchopneumonia in a child? 6. Diagnose empyema. How treat it? 7. Differentiate gallstones and appendicitis. 8. What is paranoia? 9. How would you manage a case of pulmonary tuber- culosis in an ordinary family and home, with a view to the prevention of infection to others? 10. What is the difference between active and passive hyperemia? DIAGNOSIS. 1. State pathological significance of an excessive respira- tory action of the abdomen — abdominal respiration. 2. A persistently frequent pulse in persons without fever, what affections may it suggest? 3. What pathologic significance is attached to amenor- rhea? 4. What results follow a back pressure of the superior cava? 5. State physical signs of pyloric stenosis. SURGERY. 1. Describe a compound, comminuted fracture, and give general treatment for same. 2. Where are ununited fractures most commonly found? Give some of the causes and treatment. 3. Describe ileus, and give treatment. 4. What injuries are common to the knee-joint? Give treatment for same. 5. Give diagnostic symptoms and treatment of incipient coxalgia. 6. Describe symptoms and give treatment of flat-foot. 7. Give diagnostic symptoms of tuberculous kidney. 8. Give technique of suprapubic prostatectomy. 9. Give symptoms and surgical treatment of renal calculi. 10. Describe surgical management of chronic cystitis. OBSTETRICS. 1. What factors make up the expulsive forces of labor? 2. What group of symptoms and what signs in particular would suggest to you pregnancy in a primipara at two months' gestation? 3. Give the measurements obtained by external pelvi- metry that would indicate a normal birth canal. What value can be placed upon such measurements? 4. What advantage, if any, to mother and child is gained by intermittent contractions of the uterus during labor ? 5. In endeavoring, wholly by external examination, to determine the presentation and position of the fetus at about term, what anatomical guides are employed? 520 MEDICAL RECORD. 6. Describe the development of the bladder in embryo. 7. Make a differential diagnosis between a fibroid of the uterus and an ovarian cyst. 8. Give briefly the etiology and treatment of suppurative inflammation of a vulvovaginal gland. 9. Give the causation and general symptomatology of subinvolution of the uterus. 10. What treatment would you suggest for senile vaginitis? DERMATOLOGY, SYPHILOLOGY, AND DISEASES OF THE EYE, EAR, NOSE., AND THROAT. i. Describe scabies. What is the cause of the disease? How is it treated? 2. What is dermatitis? Mention its varieties. 3. Describe psoriasis. 4. Are there any general characteristics to distinguish syphiloderma from other diseases of the skin? 5. What is syphilitic gumma? 6. How do you recognize astigmatism subjectively and objectively? 7. Define glaucoma, enumerate its varieties, and mention principal symptoms. 8. Describe symptoms of catarrhal otitis media. 9. Describe mucous polypi of nasal cavities and give their causes. 10. Chronic laryngitis : Symptoms and causes. PATHOLOGY, BACTERIOLOGY, AND HYGIENE. i. What is the microscopical appearance of the kidney during acute congestion? 2. Name the different kinds of tissue degeneration. 3. Name four possible sequelse which may follow peptic ulcer of the stomach. 4. Describe the microscopical appearance of a gumma. 5. What is the so-called "nutmeg" liver? How caused? 6. What is the morphology of Bacillus mallei f 7. What diseases are caused by the following bacteria : Shiga's bacillus, Koch-Weeks bacillus, Klebs-Loeffler ba- cillus, Diplococcus of Neisser, bacillus of Unna Ducrey? 8. What is a trap ? What purpose does it serve in drains ? 9. Describe the construction of a filter for river water to be used for drinking purposes by the people of a small city. 10. How many cubic feet of air is necessary for each patient in a general hospital? 521 MEDICAL RECORD. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Ohio State Board of Medical Registration and Examination. anatomy. i. The bones which enter into the formation of the orbit are : The frontal, sphenoid, ethmoid, superior maxillary, malar, lacrymal, and palate. 2. Nerve supply of the stomach: The pneumogastrics, and the sympathetic. 3. Ligaments of the knee-joint: Anterior, or Ligamen- tum Patellae; Posterior; Internal lateral; Two external laterals ; Capsular ; External crucial ; Internal crucial ; Transverse; Coronary; Ligamentum mucosum; and Liga- menta alaria. 4. See Cunningham's "Anatomy" (1909), page 983; or Gray's "Anatomy" (1908), page 1398. 5. See Cunningham's "Anatomy" (1909), page 1139; or Gray's "Anatomy" (1908), page 1426. 6. Coronary arteries, innominate, left common carotid, left subclavian, pericardial, bronchial, esophageal, posterior mediastinal, intercostals, and subcostal. 7. Composition of bones: (1) Organic matter (gelatin and blood-vessels) ; and (2) inorganic matter (calcium phosphate, calcium carbonate, calcium fluoride, and mag- nesium phosphate). Bones are classified as: Long, short, flat, and irregular. 8. Structures forming the larynx: Nine cartilages, viz., Thyroid, cricoid, epiglottis, two arytenoids, two cornicula laryngis, and two cuneiform. The thyrohyoid membrane, cricothyroid membrane, thyroarytenoid ligaments, capsular ligaments, hyoepiglottic ligament, thyroepiglottic ligament; and, interiorly, the vocal cords. 9. See Cunningham's "Anatomy" (1909), page 376; or Gray's "Anatomy" (1908), page 537. 10. See Cunningham's "Anatomy" (1909), page 223; or Gray's "Anatomy" (1908), page 223. PHYSIOLOGY. 1. Properties of protoplasm: (1) Irritability, or power of responding to a stimulus; (2) power of movement; (3) power of assimilation; (4) power of growth; (5) power of excretion, and (6) power of reproduction. 2. A Neuron is the unit of the nervous system; it con- sists of a nerve-cell with its processes and terminations. 3. Ameboid movement: The ameba puts out from its sides projections of the protoplasm; and later the whole 522 MEDICAL RECORD. mass flows into these projections, and thus the ameba changes its position and its shape. The white blood corpus- cles and some other cells also exhibit this same movement. 4. Capillaries are tiny blood channels, generally consist- ing of a single layer of endothelial cells, and connecting the smallest arterioles with the venules. Function: It is here that all the changes occur which take place between the blood and the tissues of the body. Oxygen and the prod- ucts of digestion and absorption are conveyed to the tis- sues, and carbon dioxide and waste matters are taken up and carried away from the tissues. 5. The forces contributing to the flow of blood through the veins are : The action of the heart, aspiration of the thorax, contraction of the muscles, and the valves in the veins. 6. Reflex actions are involuntary or unconscious move- ments, due to suitable stimuli. They depend upon the in- tegrity of the reflex arc, which is a complex made up of : (1) A surface capable of receiving an impression; (2) an afferent nerve; (3) a nerve cell capable of receiving and also of sending out impulses ; (4) an efferent nerve, and (5) a surface capable of responding in some way to the impulse conveyed by the efferent nerve. 7. Digestion is the process by which the food is converted into material suitable for absorption and assimilation. Nutrition consists in the absorption and assimilation of such physiological principles as are necessary to preserve the normal structure and function of the body. 8. The function of the hydrochloric acid in digestion: "Hydrochloric acid exerts its influence in a variety of ways. It is the main agent in the derivation of pepsin and rennin from their antecedent zymogen compounds ; it imparts activity to these ferments ; it prevents and even arrests fermentative and putrefactive changes in the food, by destroying microorganisms ; it softens connective tis- sue, it dissolves proteids and acidifies the proteids, thus making possible the subsequent action of pepsin." — (From Brubaker's Physiology.) 9. The proteids are necessary for life; they build up and repair the tissues of the body; they also supply heat and energy. A large proportion of proteid is found in : Beef, beans, cheese, fish, fowl, peanuts. 10. To make cow's milk resemble human milk: The cow's milk must be diluted and sugar of milk must be added. These modifications must be made in such propor- tions as to bring the percentage composition of the two milks as near alike as possible. CHEMISTRY. 1. Milk consists of water and solids (Proteids, fats, 523 MEDICAL RECORD. sugar, and salts). These are (roughly) about 4 per cent. each of proteids, fats, and sugar in cow's milk. The most common impurities are: (Dirty) water, micro- organisms, boric acid, formaldehyde, salicylic acid, flour, arrowroot, coloring matters, etc. 2. Acids with the ic termination contain more oxygen than the corresponding acids with the ous termination. Thus: HNO3 is nitric acid; HN0 2 is nitrous acid. The salts from the ic acids end in ate; those from the ous acids end in ite. Thus: KN0 3 is potassium nitrate; KN0 2 is potassium nitrite. 3. The alkalies, if given just before meals, increase the flow of the gastric juice; but if given towards the end of gastric digestion, they are antacid, and neutralize any ex- cessive acidity. 4. Water may be purified by: Distillation; boiling and filtration; and by precipitation, with the aid of an alum or ferric salt. 5. HC1 is made in the human body in the glands of the stomach. How it is made is not known. It is supposed to be derived from the chlorides of the blood. One view is that it is due to a reaction between the chlorides and phos- phates of the blood, thus : NaH 2 P0 4 + Nad == Na 2 HPO* + HC1. There are other views, but the matter is not settled. 6. Urates are probably precipitated in the bladder owing to concentration and absorption of water from the urine; also from acid fermentation. Urates may be recognized by: (1) Their pinkish color; (2) dissolving upon warming the urine; (3) their ^ appearance under the microscope (amorphous or crystalline). 7. A calcium sulphide is a binary compound whose mole- cule consists of one atom of calcium and either one or two or five atoms of sulphur, CaS., CaS 2 , or CaS 5 . The monosulphide, CaS, is a white amorphous substance, but slightly soluble; when heated, it shines in the dark. It is used for making luminous paints, also as a depilatory. 8. Common properties of the mineral acids: They are acid in reaction and in taste, are irritant, and corrosive. 9. Symptoms of carbolic acid poisoning: Buccal mucous membrane is whitened and hardened; vomiting; burning pain in mouth, esophagus, and stomach; pulse and body temperature are lowered; the pupils are contracted; col- lapse, and finally death. The urine may become dark. The treatment of carbolic acid poisoning consists in ad- ministering white of cgg f sodium sulphate, or saccharated lime, followed by lavage. Alcohol is said to be antidotal. 10. Physiological antidotes act as such by combating the physiological action of the poison. 524 MEDICAL RECORD. Physiological antidotes for strychnine: Chloral hydrate, chloroform. MATERIA MEDICA AND THERAPEUTICS. i. Mercury is a shining, silver- white metal, without odor or taste, liquid at ordinary temperature, and easily divisible into spherical globules. Ammoniated mercury: White pulverulent pieces or a white amorphous powder, with an earthy or styptic or metallic taste; insoluble in water or alcohol. Mercury with chalk: A light gray, rather damp powder, odorless, with a slightly sweetish taste. Corrosive sublimate: Heavy, odorless crystals, colorless, acrid metallic taste. Calomel: White, impalpable powder, odorless, tasteless, insoluble in alcohol, water, or ether. Yellow mer curous iodide: Bright yellow, amorphous pow- der, odorless, tasteless, becomes darker on exposure to light, almost insoluble in water. Red mercuric iodide: A scarlet red, amorphous powder, odorless, tasteless, almost insoluble in water. Yellow mercuric oxide: Light orange- yellow, heavy, amorphous powder, impalpable, odorless, metallic taste, almost insoluble in water. Red mercuric oxide: Heavy, orange-red, crystalline scales, or crystalline powder, odorless, metallic taste, almost insoluble in water. 2. The more important official preparations of digitalis are : The tincture and the infusion. Of these the tincture is generally given for its action on the heart, and the infu- sion for its diuretic action. 3. Antidiphtheritic serum (dose 3,000 units) is official; tuberculin, tetanus antitoxin (dose 3ijss to 5v), antistrep- tococcic serum (dose 3ijss to 5v), and some others are also used. Sera may be administered by hypodermic injection or by mouth. The use of the above mentioned sera is indicated by their names. 4. Iodides should be administered in a syrup, such as the compound syrup of sarsaparilla. No other drug should be administered with it. The iodides are incompatible with the mineral acids, me- tallic salts, ammonia, alkaloids and their salts. 5. As a general rule, ether would be the anesthetic of choice. But chloroform may be used: (1) in hot climates; (2) when large numbers of persons have to be rapidly anesthetized; (3) in brain surgery; (4) in labor; (5) in patients who are known to take ether badly; and (6) in the conditions mentioned below, in which ether is contra- indicated. The following contraindications for ether and chloro- form are from Hare's Practical Therapeutics: "Ether should not be used by inhalation in bronchitis or acute nephritis because of its irritant properties; in peritonitis 525 MEDICAL RECORD. or gastritis, because it is apt to induce vomiting; in aneurysm or in the presence of marked vascular atheroma, because it may rupture a blood-vessel by raising arterial pressure; nor in diabetes, lest it produce diabetic coma; and if anemia is present and an examination of the blood shows that the hemoglobin is below 50 per cent., the use of the drug should be avoided if possible. "Chloroform, is not to be used in cases of fatty heart or dilatation of the heart, in those with a known idiosyncrasy, nor in the so-called lymphatic persons with overgrowth of lymphoid tissues, as, for example, adenoids. In the latter case it is particularly apt to cause sudden death. In valvu- lar disease of the heart chloroform may be used with caution, although ether is preferable. Given a case of valvular disease that must be subjected to operation, the chances are bettered with an anesthetic than without it, as the pain and mental shock are worse for the heart than is the anesthetic." 6. In neurasthenia and hysteria. See French's "Practice of Medicine" (1907), page 1149. 7. Symptoms of continued use of cocaine: Emaciation, mental and moral impairment, delusions, circulatory dis- turbances, and insomnia. Treatment consists in sustaining the patient's strength ; nitrite of amyl or ammonia may be inhaled; belladonna and caffeine have been tried ; stimulants are indicated. 8. Digitalis is indicated: (1) When the heart action is rapid and feeble, with low arterial tension; (2) in mitral lesions when compensation has begun to fail; (3) in non- valvular cardiac affections ; (4) in irritable heart, due to nerve exhaustion. Digitalis is contraindicated in diseases of the heart (1) in aortic lesions when uncombined with mitral lesions; (2) when the heart action is strong and arterial tension high. Nitrites are indicated: When arterial tension is high, in angina pectoris, epilepsy, asthma, cardiac dyspnea, puer- peral eclampsia, chronic nephritis, arteriosclerosis. 9. Alkaloids are organic nitrogenized substances, alka- line in reaction, and capable of combining with acids in the same way that ammonia does. General properties of alkaloids: Alkaloids are of two kinds, volatile and fixed. The volatile alkaloids are liquid, readily volatile without decomposition, and consist of C, H, and N. The fixed alkaloids are for the most part solid and crystalline, not, or only partially, volatile without decompositon, and consists of C, H, N, and O. Most of the alkaloids are alkaline in reaction, of a bitter taste, and of white color. Most of the alkaloids are nearly insoluble in water, but are soluble in alcohol, chloroform, ether, and benzine ; 526 MEDICAL RECORD their salts are generally soluble in water and alcohol, but insoluble in the other solvents just named. They combine with acids to form salts in the same way that ammonia does. 10. Galvanic current is best when the brain, spinal cord, and sympathetic system are to be influenced ; also for middle and internal ear, and retina ; also for neuralgia, rheumatism, and muscular atrophy. Faradic current is indicated in diseases of the abdominal viscera and in gen- eral muscular debility. PRACTICE OF MEDICINE. i. In diphtheria, pneumonia, scarlet fever, and empyema, the leucocyte count is probably over 25,000. 2. HYDRONEPHROSIS OVARIAN CYSTS 1. Enlargement unilateral and from above downward. Growth fixed in region of kidney. 2. Expression unchanged. 3. Growth usually slow. 4. Intestines may be in front of tumor. 5. Fluid not necessarily albuminous ; may contain calculi. 6. Vaginal touch nega- tive. 7. Urine may contain pus, blood, or albumin. 8. Cystoscopy shows ab- sence of urine through ure- ter on affected side. Exceptions. — In case of a movable kidney the tumor may not be fixed. 1. Enlargement at first unilateral ; later symmet- rical and from below up- ward. No fixation. 2. Facies ovariana. 3. Growth relatively rap- id. 4. Intestines in the flanks above and back of tumor. 5. Fluid albuminous; no calculi. 6. Tumor usually felt by vaginal touch. 7. Urine generally normal. 8. Urine flows through ureter on both sides. Exceptions. — In case of adhesions the cyst may be fixed. (From Dudley's Gynecology.) 3. See French's "Practice of Medicine" (1907). page 963. 4. In aortic stenosis: A systolic murmur heard over the aortic area, transmitted into the carotids, and usually accompanied by a loud first sound. Hypertrophy of the left ventricle, increased area of cardiac dullness, apex beat is displaced downward and to the left, the pulse is gen- erally small and infrequent. 5. See French's "Practice of Medicine" (1907). page 674: or Osier's "Practice of Medicine" (1909), page 626. ??7 MEDICAL RECORD. 6. Empyema is diagnosed by : High and irregular fever, sweats, chill, diminished breath sounds and vocal fremitus, impaired mobility of chest, dullness on affected side, heart displaced to opposite side, leucocytosis. Absolute diagnosis is made by aspiration, showing the fluid to be pus. Treatment : Aspiration, drainage, irrigation, resection of ribs (Estlander's operation), or resection of chest wall ( Schede's operation) . 7. In gallstones: The pain is in the region of the liver; it radiates to the right scapula and toward the umbilicus; chills and sweats are common; also vomiting, and some- times symptoms of collapse and jaundice; calculi may be found in the feces. In appendicitis: The pain is at first diffuse, but later be- comes localized over the appendix in the right iliac fossa; nausea, vomiting, and constipation may be present; tender- ness oyer the appendix and rigidity of the right rectus ab- dominis muscle are present; there is generally moderate fever. 8. Paranoia is a primary chronic form of insanity, oc- curring especially in degenerates, and marked by hallucina- tions and delusions which are systematized, i.e. exhibit a logical connection and sequence, so that the patient from his perverted ideas, in which he firmly believes, draws log- ical and coherent influences. (From Duane's Medical Dictionary.) 9. Hygienic precautions to be taken in treating a case of tuberculosis : "The patient's quarters should be free from dust and admit of spending many hours daily in the open air in all weathers, properly sheltered, and, if very ill, lying wrapped in a hammock or reclining chair. His bed-room should be well aired at night, draughts being avoided. The room should be uncarpeted and free from hangings. It should be often cleaned and periodically disinfected. All sputum should be collected in paper spit-cups, which should be burned daily. Smoking should be forbidden. Harm is done by any exercise which results in fatigue, and while fever exists it should not be attempted at all. Patients should be taught the necessity of practising lung gym- nastics and breathing only through the nose, which should be kept clear and free from occlusion by secretions, or an hypertrophied catarrhal mucosa. * * * The clothing should be woolen, but not too heavy, or sweating is in- creased : and a flannel nightgown and loosely knit leggings should be worn at night in cool weather. The skin should be cleansed by daily sponge-baths of lukewarm alcohol and water." — (Thompson's Practical Medicine.) 10. In active hyperemia there is an excess of arterial blood in a part, with, generally, acceleration of flow. In passive hyperemia the excess of blood is in the veins 528 MEDICAL RECORD. and capillaries, and the flow is retarded ; it is generally due to some mechanical obstacle. DIAGNOSIS. i. "The causes of excessive respiratory action of the abdomen — ue. of the diaphragm — are found in conditions which render movement of the thorax painful, such as pleurisy, pleurodynia, or fracture of a rib; or which mechanically hinder thoracic expansion, as in double pleu- ral effusion, calcification of the costal cartilages, emphy- sema (permanent inspiratory form of the thorax throwing extra work upon the diaphragm), the rare scleroderma of the chest wall, and ossifying myositis. Inaction of the thorax may also be due to paralysis of the muscles of inspiration, as in injury or diseases of the cervical portion of the cord or bulbar paralysis, or spasm of the same muscles in strychnine poisoning or tetanus." (Butler's Diagnostics of Internal Medicine.) 2. A persistently frequent pulse in persons without fever may suggest: Phthisis, exophthalmic goiter, Addi- son's disease, pernicious anemia, chlorosis, locomotor ataxia; also neurasthenic conditions, sexual excesses, abuse of alcohol, coffee, or tobacco. 3. Amenorrhea may indicate: Hysteria, melancholia, mental overwork, anemia, phthisis, nephritis, diabetes, cancer, malaria, leukemia, morphine habit. 4. Back pressure in the superior cava is followed by: Cyanosis of the lips and face, clubbing of the fingers, and (with tricuspid regurgitation) a systolic jugular pulse. 5. The physical signs of pyloric stenosis are : The stom- ach may be observed to be dilated, a tumor may be felt at the pylorus, splashing or succussion sounds may be ob- tained. SURGERY. 1. See Rose and Carless' "Surgery" (1908), page 482; or Da Costa's "Surgery" (1908), page 464. 2. The united fractures are most commonly found in: Patella, olecranon, coracoid process, humerus, neck of femur. Causes: Wide separation of the fragments, interposition of soft parts, want of rest, defective blood supply, bone disease. Treatment : Continued immobilization in plaster of paris, with use of limb (if it does not increase the displacement) ; rubbing the ends of the bone together; refreshing the bony ends and fixing by plates, or wires, or screws ; or retentive apparatus. 3. See Rose and Carless' "Surgery" (1008), pages 11 11 and 1 1 15: or Da Costa's "Surgery" (1908), pages 839 and 841. 529 MEDICAL RECORD. 4. Injuries common to knee joint are : Sprains, disloca- tions, penetrating wounds, fracture into the joint, fracture of patella, rupture of quadriceps tendon or of ligamentum patellae, displacement of semilunar cartilage. For treatment, see Rose and Carless' "Surgery" (1908), or Da Costa's "Surgery" (1908), index, under these head- ings. 5. The early symptoms of hip-joint disease are : Night cries (in a child) ; lameness in the morning; a slight limp; tendency to become tired on slight exertion; wasting; spasm; pain; swelling; and deformity (either real or apparent). Treatment: In the early stages, rest in bed is indicated, with extension; also tonics, restoratives, fresh air. If necessary, the limb should be straightened and put up in plaster-of-paris, or a brace or other mechanical appliance should be used. Intraarticular injections of iodoform have been recommended. Resection of the hip may be necessary. 6. See Rose and Carless' "Surgery" (1908), pages 1175 Da Costa's "Surgery" (1908), page 663. 7. The diagnostic symptoms of tuberculous kidney are : Frequent micurition, with pus, and sometimes blood in the urine ; pain and tenderness over the kidney, enlarge- ment of kidney; chills, fever, and sweats; tubercle bacilli may be found in the urine ; the cystoscope will show a retracted ureteral, meatus on the affected side; the symp- toms are not made worse by movement or improved by rest. 8. See Rose and Carless' "Surgery" (1908), page 1229; or Da Costa's "Surgery" (1908), page 1191. 9. See Rose and Carless' "Surgery" (1908), pages 1175 and 1178; or Da Costa's "Surgery" (1908), pages 1110 and 1 1 18. 10. See Rose and Carless' "Surgery" (1908), page 1193; or Da Costa's "Surgery" (1908), page 1137. OBSTETRICS. 1. The factors in the expulsive forces of labor are : The uterine contractions and the contractions of the diaphragm and of the abdominal muscles. 2. At two months none of the certain signs would be present. Cessation of menstruation, in a woman who had previously been regular, with morning sickness, increased frequency of micturition, softened cervix and breast signs (enlarged breast, more prominent veins, deeper pigmenta- tion) would all be very suggestive, especially in a primi- para. 3. See Williams' "Obstetrics" (1909), page 684; or Hirst's "Obstetrics" (1909), page 448. 4. The intermittency of the contractions enables the 530 MEDICAL RECORD mother to "rest" in between the pains, hence it is a saving to her ; it also is a protective measure for the child. 5. See Williams' "Obstetrics" (1909), page 211; or Hirst's "Obstetrics" (1909), page 388. 6. See Cunningham's "Anatomy" (1909), page 1202. UTERINE MYOMA. 1. Slow growth. 2. Facial expression un- changed. Face may be full and flushed; later pale from hemorrhage. 3. General health usual- ly unimpaired except from loss of blood, if submucous or mural; may be painful. 4. Abdomen usually very asymmetrical from irregu- lar shape of tumor. 5. Abdominal veins not usually enlarged. 6. Action of kidneys nor- mal. 7. Usual menorrhagia. 8. Elasticity, not fluctua- tion. No percussion wave. 9. Surface firm and usual- ly lobulated. 10. Vaginal touch and conjoined examination show tumor dense and firm, and, unless pedunculated, con- tinuous with uterus. Uterus large and heavy. 11. Uterine cavity much elongated. 12. Uterus moves with tu- mor. 13. Negative results from aspiration, but aspiration is not advised. Exception. — A subperito- neal myoma with a long pedicle moves independently of the uterus, and the uter- OVARIAN CYSTOMA. 1. Usually growth. more rapid 2. Facies ovariana. 3. General health early impaired from emaciation. Not painful. 4. Abdomen more sym- metrical, especially when tu- mor is large. 5. Usually enlarged, espe- cially in large polycysts. 6. Kidneys less active. 7. Menstruation unchang- ed or diminished. 8. Fluctuation marked. Percussion wave marked. 9. Surface yielding; in monocysts, regular ; in poly- cysts, irregular. 10. Uterus normal, except displacement from pressure. Tumor compressible, fluctu- ating, detached from uterus. 11. Not materially elon- gated. (This is a most im- portant diagnostic point.) 12. Does not move with tumor. 13. Positive results from aspiration, but aspiration is not advised. Exception. — A cyst with semisolid contents yields negative results on aspira- tion. Fluctuation, if pres- 531 MEDICAL RECORD. UTERINE MYOMA. ine cavity is not necessarily lengthened. If the myoma has degenerated to a fibro- cyst there will be more or less fluctuation, and aspira- tion may yield positive re- sults. OVARIAN CYSTOMA. ent, is indistinct, and per- cussion wave is absent or indefinite. (From Dudley's Gynecology.) 8. Suppurative inflammation of vulvo- vaginal gland. Etiology: Gonorrhea, or suppuration following cellulitis. Symptoms: The same as abscess anywhere else (redness, swelling, heat, pain, and sometimes fever and fluctuation). Treatment: Excision, or incision and drainage. 9. See Williams' "Obstetrics" (1909), page 904; or Hirst's "Obstetrics" (1909), page 645. 10. Treatment of senile vaginitis: When the subjective symptoms are not annoying, do little or nothing. Vaginal douche with hot normal salt solution; or corrosive subli- mate solution (1 in 10,000), followed by saline solution; tampons of ichthyol and glycerin (1 to 10) ; ulcers may be painted with a mild solution of silver nitrate occa- sionally. DERMATOLOGY, SYPHILOLOGYj and diseases of the eye, ear, NOSE, AND THROAT. i. Scabies in a contagious animal parasitic disease, due to the Sarcoptes scabiei, characterized by burrows and a multiform eruption, and attended by severe itching. The eruption usually occupies certain areas where the skin is thin; these are the interdigital spaces, the flexor surface of the wrist and arm, the anterior and posterior axillary folds, the mammae and nipples (in women), the umbilicus, the buttocks, the penis, the inner side of the thighs and legs, and the toes. The face is exempt except occasionally in infants. The itching is intense and worse at night. The affection is curable, but dermatitis may result from over- treatment. Treatment consists in a thorough scrubbing with soap and warm water, followed by friction to dry the skin, and the application of sulphur ointment; the latter to be re- peated morning and night for three days. The whole process may need to be repeated one or more times. 2. Dermatitis is inflammation of the skin. Varieties: Dermatitis blastomycotica, bullosa, calorica, ambustionis congelationis, contusiformis, epidemica, exfoliativa, exfolia- tiva neonatorum, gangrenosa, herpetiformis, malignant 532 MEDICAL RECORD papillary, medicamentosa, papillaris capillitii, repens, sebor- rheica, traumatica, venenata. 3. Psoriasis: "A common chronic inflammatory disease of the skin, characterized by variously sized lesions having red bases, covered with white scales resembling mother-of- pearl. It affects by preference the extensor surface of the body. The lesions are infiltrated, elevated, clearly de- fined, covered with white, shining, easily detachable scales which, upon removal, reveal a red, punctate; bleeding sur- face. The eruption is absolutely dry, and itching is usually absent." — (Gould and Pyle's Pocket Cyclopedia.) 4. Syphilitic skin eruptions are characterized: By not itching; by being of a coppery or raw ham color; by being painless ; by polymorphism, macules, papules, pustules, etc., being present at the same time; by being generally sym- metrical. 5. See Rose and Carless' "Surgery" (1908), page 152; or Da Costa's "Surgery" (1909), page 285. 6. Astigmatism. Subjective symptoms: Headache, nau- sea, anorexia, indigestion, inability to perform near work continuously; in reading there is confusion of letters. Ob- jective tests: By cards, dials, stenopaic disc, keratoscope, ophthalmoscope, ophthalmometer, retinoscope, test lenses. For details of the use of these see a good book on eye diseases. 7. Glaucoma is a diseased condition of the eye, produced by increased intraocular pressure, and resulting in excava- tion and atrophy of the optic disc, and blindness. It is due to increase of the contents of the eye, hypersecretion, re- tention, old age, gout, rheumatism, nephritis. Varieties: Primary, secondary, inflammatory, simple, acute, chronic, infantile, malignant, absolute, and hemorrhagic. Symp- toms: Visual disturbances, increased ocular tension, hazy and anesthetic cornea, sluggish and dilated pupil, shallow anterior chamber, ciliary neuralgia, cupping of optic disc, blindness. 8. See Rose and Carless' "Surgery" (1908), page 882. 9. See Rose and Carless' "Surgery" (1908), page 831. 10. See French's "Practice of Medicine" (1907), page 645; or Osier's "Practice of Medicine" (1909), page 597. PATHOLOGY, BACTERIOLOGY, AND HYGIENE. i. See French's "Practice of Medicine" (1907), page 878; or Osier's "Practice of Medicine" (1909), page 667. 2. Kinds of tissue degeneration: Cloudy swelling; fatty infiltration and degeneration ; amyloid, mucoid, hyaline, and colloid degenerations; glycogenic infiltration; hy- dropic ; and bone caries. 3. Four possible sequela of peptic ulcer of the stomach: 533 MEDICAL RECORD. Hemorrhage, perforation, gastroduodenal fistula, peri- tonitis. 4. See Rose and Carless' "Surgery" (1908), page 152. 5. See French's ''Practice of Medicine" (1907), page 817; or Osier's "Practice of Medicine" (1909), page 541. 6. Bacillus mallei is a small bacillus, straight or slightly curved, generally with rounded ends, about the same length as the tubercle bacillus, but is shorter and thicker than the latter, is non-sporogenous, non-motile, non-liquefying, non-chromogenic, aerobic, grows on the ordinary media and particularly well in the presence of glycerin. 7. BACTERIA Shiga's bacillus. Koch- Weeks bacillus. Klebs-LoefBer bacillus. Diplococcus of Neisser. Bacillus of Unna-Ducrey. DISEASES CAUSED BY Dysentery. Conjunctivitis. Diphtheria. Gonorrhea. Chancroid. 8. A trap is a bend in a pipe; it contains water, and serves to prevent the passage of sewer gases into houses. 9. Ordinary filter beds for the purification of water are tanks of varying size, shape, and construction; the walls may be vertical or sloping; upon the paved bottom are pipes to carry off the filtered water. Above these pipes are successive layers of coarse gravel, fine gravel, coarse sand, and at the top fine sand about four feet deep. Through these layers the water passes. 10. The air space for sick people should be at least one- fourth more than that allowed for well people. Hence, 1,000 cubic feet + 250 cubic feet = 1,250 cubic feet of space should be allowed in hospitals for each person. Of course, as much more than this as is possible, provided it is properly warmed and distributed, is desirable. STATE BOARD EXAMINATION QUESTIONS. Oklahoma State Board of Medical Examiners. physiology. 1. What effect has respiration upon the circulation? 2. What is the action of the nervous system upon the salivary glands? 3. What is the function of gastric juice? 4. What is the nervous mechanism of stomach digestion? 5. What are the functions of the liver? 6. What circumstances affect glandular activity? 7. What is a ganglion? 534 MEDICAL RECORD. 8. What is the effect of stimulation of the divided optic nerve? 9. What is the dutv of the large intestine in digestion? 10. What are the uses of the blood? CHEMISTRY. 1. How may ferric hydrate be hurriedly prepared? When and how should ferric hydrate be used as an antidote? 2. How may lead enter the system and produce lead poisoning? oive a diagnosis of lead poisoning and mention the chemical antidotes for it. 3. Mention the principal products obtained from petro- leum and describe the properties of one of the products mentioned. 4. How is chloroform (a) prepared, (b) tested for im- purities? 5. Mention a chemical antidote for sulphuric acid and explain the action of this antidote. 6. How would you detect the presence of bile in the urine? 7. Designate the following as chemical or physical changes: (a) The souring of milk; (b) decomposition of sunlight by means of prisms; (c) converting water into steam; (d) dissolving salt in water; (e) decay of wood. 8. Technical name of: (a) Aqua regia, (b) aqua fortis, (r) oil of vitriol. 9. Give the formula for: (a) Mercuric chloride, (b) cupric nitrate, (c) calcium carbonate. 10. Give formula for carbolic acid. How is it obtained and what are its properties and uses? PATHOLOGY AND BACTERIOLOGY. i. What are some of the phenomena attending pus for- mation ? 2. What are some of the conditions favorable to the in- crease of bacteria; and what is meant by their toxic prod- ucts? 3. What is immunity and how produced? 4. Describe the protective agencies by which the body guards itself against the entrance and harmful effects of pathogenic microorganisms. 5. Describe the comma bacillus, and give the manner of its introduction into the system. 6. How should sputum be examined for tubercle bacilli ? 7. What is ischemic paralysis? 8. Describe syphilitic gummata. 9. Give the probable causes of occlusion of the bile duct. 10. W f hat are cysts, and how formed? PHYSICAL DIAGNOSIS. 1. Diagnose mitral regurgitation. 535 MEDICAL RECORD. 2. Give the physical signs of pericarditis. 3. How would you diagnose aneurysm of the thoracic aorta ? 4. Describe the physiological action of the heart. 5. Define rude respiration, bronchial respiration, cavern- ous respiration, and amphoric respiration. 6. Classify pulmonary tuberculosis. What is the posi- tive diagnostic sign? 7. Describe test for blood in urine. 8. Give physical signs in acute appendicitis. 9. Describe the normal signs of the heart. 10. Give physical signs of acute otitis media. THEORY AND PRACTICE OF MEDICINE. i. Write a prescription for (a) a collyrium, (b) a sup- pository, and (c) a mouth wash. 2. Prescribe a local application for erysipelas, for rhus toxicodendron poisoning; also write a prescription for night sweats of phthisis, for ascites, and for ptyahsm. 3. In what disease does leucocytosis occur, and in what diseases is it absent? 4. Give the cause and treatment of bronchial, spasmodic, or essential asthma. 5. Describe the Brand method of treatment in typhoid fever, and what is your opinion of the same? 6. Describe the skin appearance in (a) rubeola, (b) rubella, (c) scarlatina, and (d) varicella. 7. Give etiology, symptoms, and treatment of gastroin- testinal catarrh of intancy and childhood. 8. Make a differential diagnosis between renal colic and hepatic colic. 9. What are the symptoms of obstruction of the ductus communis choledochus? 10. Differentiate heat exhaustion from sunstroke. OBSTETRICS AND HYGIENE. 1. Differentiate a foot from a hand presentation. What would you do in either case? 2. What is the bag of waters? What is its function during pregnancy ? During labor ? 3. How diagnose hour-glass contraction with retained placenta? (b) Give treatment. 4. After the fifth month, how may death of fetus in utero be recognized; (b) what should be done? 5. When and how is the pk centa formed? 6. (a) State fully the duties of physicians as required by the statutes of Oklahoma, (b) What diseases must be re- ported to the State Commissioner of Health? 7. What are the dangers of cold storage foods? 536 MEDICAL RECORD. 8. What evil consequence n:ay arise from the use of to- bacco ? 9. Describe procedure in disinfecting and disposing of typhoid fever stools. 10. (a) How much water per dav, in ounces, should be consumed by an average adult? (b) Mention most fre- quent pollution of water, (c) Give test for organic mat- ter in water. GYNECOLOGY. 1. Name the most frequent causes of endometritis; (b) give treatment, both palliative and surgical. 2. What is atresia of the vagina? Give treatment. 3. Give most frequent causes of pyosalpinx; diagnosis and treatment. 4. Differentiate between menorrhagia, metrorrhagia, and amenorrhea, (b) Give treatment of each. 5. Give treatment of prolapsus uteri, both palliative and surgical. 6. Differentiate between ovaritis, cystic ovary, and sal- pingitis. 7. Give symptoms and treatment of extrauterine preg- nancy. 8. Describe the female genital and pelvic organs, and give their functions. SANITARY SCIENCE. i. In case you were a health officer, what regulations would you prescribe governing schools, water supply, and sewerage? 2. What would be the most important precautions to be observed for the preservation of health in a city of 20,000 people? SURGERY. 1. Define hemorrhoids, name varieties, and give treat- ment. 2. Give differential diagnosis between osteomyelitis and acute rheumatism, and describe treatment of former. 3. Give technique of tracheotomy. 4. Diagnosis and treatment of strangulated inguinal hernia. 5. Give your rule for locating and method of ligating the femoral artery in situ. 6. Diagnose and give treatment of dislocation of the astragalus. 7. Name and describe the measurements you would use in ascertaining whether or not there is shortening in neck of femur in case of suspected impacted fracture. 8. What would be your treatment of compound fracture of tibia with laceration of the anterior tibial artery? 537 MEDICAL RECORD 9. Differentiate floating kidne^ from other abdominal tumors, and describe treatment for same. 10. Give diagnosis and treatment of intussusception. MEDICAL JURISPRUDENCE. i. What conditions would you find in a case of rape of a girl of twelve years? 2. Enumerate the causes of sudden death. 3. Give the difference between an incised wound made before and one made after death ; also gunshot wound. 4. Give the cause and duration of rigor mortis. 5. To what kind of a crime does strangulation point; tlso hanging? TOXICOLOGY. 1. What is the antidote and treatment of oxalic acid poisoning? 2. Give the detailed account of post-mortem appearance of carbolic acid poisoning. 3. What are the symptoms and treatment of poisoning with bichloride of mercury? 4. What is the antidote for strychnine? 5. Mention ten drugs, the use of any one of which may cause skin eruptions. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Oklahoma State Board of Medical Examiners. physiology. 1. The respiratory changes in the blood: (1) In the lungs the blood is changed in color, gains oxygen, loses carbon dioxide, loses heat, and loses watery vapor. (2) In the capillaries of the body the blood loses oxygen and re- ceives carbon dioxide. 2. The submaxillary gland is supplied by the chorda tympani (which contains secretory fibers and vasodilator fibers). The sympathetic slows the secretion of saliva in parotid and submaxillary glands. In the parotid gland the auriculotemporal is the secretory nerve. The secretion of saliva is a reflex action ; the afferent nerves being : The glossopharyngeal, the lingual branch of the fifth, and the chorda tympani; the efferent nerves are: Sympathetic nerves, auriculotemporal branch of the fifth, and chorda tympani. 3. The function of gastric juice is: (1) To change pro- teids into proteoses and peptones; (2) to curdle the casein of milk; (3) it is also antiseptic. 4. The pneumogastric nerves are motor to the stomach, 538 MEDICAL RECORD and induce peristalsis ; the sympathetic fibers are inhibi- tory, causing cessation of peristalsis and dilatation of the sphincter pylori. 5. The functions of the liver are: (1) The secretion of bile, (2) the formation of glycogen, (3) the formation of urea and uric acid, (4) the manufacture of heat, and (5) the conversion of poisonous and harmful into inert ma- terial. 6. Circumstances affecting glandular activity are: Blood supply; nerve impulses (trophic, secretory, vasomotor) ; sometimes food, sensations, or emotions. 7. A ganglion is an aggregation of nerve cells, connected with nerves, or other ganglia, or with the cerebrospinal axis ; masses of gray matter at the base or in the interior of the brain are also called ganglia. 8. Stimulation of the divided optic nerve causes : Flashes of lig-ht, but no pain. 9. In the large intestine: Digestion which is already begun may continue, but there is no special digestive action ; there is marked absorption of water; there are numerous bacteria, and, as a consequence, proteid putrefaction. 10. The functions of the blood as a whole are: To dis- tribute nourishment, oxygen, and the internal secretions to the tissues of the body; to remove carbon dioxide and other waste matters from the tissues so that they may be excreted b^ the lungs, kidneys, and skin ; to regulate the body temperature. In addition the white corpuscles serve as a protection to the body from the incursions of patho- genic microorganisms ; they take some part in the process of the coagulation of the blood ; they aid in the absorption of fats and peptones from the intestine, and they help to maintain the proper proteid content of the blood plasma. CHEMISTRY. 1. Ferric hydrate may be hurriedly prepared by precipi- tating solution of ferric sulphate with magnesia. The two solutions should be kept in separate bottles, and when needed thev may be mixed and administered. It is used as an antidote in acute arsenical poisoning. 2. The most common sources of lead poisoning are the following: 'The contamination of drinking water from lead pipes. Contamination of articles of food or drugs by contact witn leaden vessels, or from being enclosed in tin- foil containing an excess of lead. Drinking beer, cider, etc., which has been drawn through leaden pipes or allowed to stand in pewter vessels. The ingestion or constant handling of lead or its compounds, as the acetate, nitrate, carbonate (white lead — painter's colic), Goulard's extract, etc. The use of hair dyes containing lead." Lead poisoning causes: Metallic taste, dryness of throat, 539 MEDICAL RECORD. thirst, severe, colicky abdominal pains, particularly in um- bilical region; pulse feeble and slow; great prostration; constipation; urine scanty and red; violent cramps; par- alysis of lower extremities; convulsions; tetanic spasms, and (in chronic cases) wrist drop. Chemical antidote is magnesium sulphate. 3. Principal products of petroleum are: Paraffin, vase- line, kerosene, benzine, gasoline, mineral oils, rhigolene. Vaseline is a yellowish or whitish fatty substance, with slight odor and taste, and is sticky. 4. Chloroform is prepared bv the action of calcium hypo- chlorite on acetone. It is tested: (1) For excess of alco- hol, by taking the specific gravity ; (2) for HC1 and CI, by shaking it with water, which afterward should not give a precipitate with AgN0 3 . 5. Chemical antidote for sulphuric acid is magnesia; it acts by neutralizing the acid and converting it into a harm- less salt. 6. Test for bile pigment in the urine: Put 3 c.c. HNOr in a test-tube ; add a piece of wood, and heat until the acid is yellow; cool. When cold, float some of the urine to be tested upon the surface of the acid. A green band is formed at the junction of the liquid, which gradually rises, and is succeeded from below by blue, reddish-violet, and yellow. 7. (a) Chemical; (b) physical; (c) physical; (d) chem- ical; (e) chemical. 8. (a) Aqua regia is nitrohydrochloric acid; (b) aqua fortis is nitric acid; (c) oil of vitriol is sulphuric acid. 9. (a) Mercuric chloride, HgCl 2 ; (b) cupric nitrate, Cu (NOs)2; (c) calcium carbonate, CaCOs. 10. Carbolic acid, C 6 H 5 OH. It is obtained by heating phenyl iodide and potassium hydroxide. It is a crystalline substance, with characteristic odor and acrid, burning taste, neutral in reaction, and very soluble in alcohol and ether. It is used as an antiseptic and in the manufacture of medicinal compounds, dyes, and explosives; also as a local anesthetic, for pruritus, and sometimes internally in ner- vous vomiting. PATHOLOGY AND BACTERIOLOGY. i. See Da Costa's "Surgery" (1908), pages 127, 130, and 132. 2. Most bacteria require (1) proper temperature, gen- erally at or near that of the body; (2) oxygen is generally needed, those that cannot live without it' being called aerobic, and those that can grow without it, anaerobic; nutriment of a proper kind, containing both organic and inorganic material; a slight degree of moisture; a medium of slightly alkaline reaction, and rest. Individual bacteria may require modifications of the above essentials. 540 MEDICAL RECORD. By the toxic products of bacteria is meant the production of disease or infection by bacteria. 3. Immunity is the power of resistance of cells and tissues to the action of pathogenic bacteria. Immunity may be either natural or acquired. Natural immunity is this power of resistance, natural and inherited, and peculiar to certain ^roups of animals, but common to every individual of these groups. Acquired immunity is this resistance acquired: (1) By a previous attack of the disease caused by the bacteria, or (2) by the person being made artificially insusceptible. The conditions which give immunity from the pathogenic action of bacteria are: (1) A previous attack of the dis- ease; (2) inoculation with small quantities of bacteria, so as to produce a mild attack of the disease; (3) vaccina- tion; (4) the introduction of antitoxins; (5) the introduc- tion of the toxins of the bacteria. Several theories have been advanced to account for immunity, but the only two that are considered now are: (1) MetchnikofT's theory of phagocytosis and (2) Ehr- lich's side-chain theory. This latter "is based on the idea that the toxin destroys a cell by entering into chemical union with it. The molecule of toxin contains at least two groups of atoms, a toxophore group, in which the poison- ous principle resides, and a haptophore group, which brings the toxophore group into touch with the cell and through which chemical combination takes place. Similarly, the cell contains a haptophore group, but the toxophore group of the toxin can only unite with it and destroy it when its haptophore companion has affinity with that of the cell. If that affinity does not exist the two haptophore groups do not unite, the toxophore group does not come into contact with the cell, and the animal is immune. Such is natural immunity. If there is affinity and the cell can throw off a haptophore group (antitoxin), which in its detached con- dition unites with the haptophore group of the toxin, the toxophore group has then nothing with which it can unite and the animal is immunized. When the individual has to contend with a tacterium as well as its toxin, the same principle obtains. Immunity is established by the produc- tion of a double haptophore group, one for the bacterium, the other for its toxin/' — (Stenhouse's Pathology.) 4. The chief protective agencies by which the body guards itself against the entrance and harmful effects of pathogenic microorganisms are : The acidity of the gastric juice, urine, and the vaginal secretion : the alkalinity of the blood; the agglutinating action of the blood; the bacte- ricidal action of the blood and lymph; the action of leuco- cytes and phagocytes; the general antitoxic action of the organism. 541 MEDICAL RECORD. 5. The comma bacillus is a spirillum, actively motile, and with a flagellum at one end ; it is curved, has rounded ends, and is about half the length of the tubercle bacillus; it stains readily with ordinary anilin stains, but not by Gram's method; it is easily cultivated on the usual media; it has but slight power of resistance; it liquefies gelatin, and does not produce pigment. It may be introduced into the system by: water, milk, food, fingers, and flies. 6. To demonstrate the existence of tubercle bacilli in the sputum : The sputum must be recent, free from particles of food or other foreign matter; ielect a cheesy-looking nodule and smear it on a slide, making the smear as thin as possible. Then cover it with some carbolfuchsin, and let it steam over a small flame for about two minutes, care being taken that it does not boil. Wash it thoroughly in water and then decolorize by immersing it in a solution of any dilute mineral acid for about a minute. Then make a contrast stain with solution of Loeffler's methylene blue for about a minute; wash it again and examine with oil immersion lens. The tubercle bacilli will appear as thin red rods, while all other bacteria will appear blue. 7. Ischemic paralysis is a local paralysis due to stoppage of the circulation in a part (often the result of embolism or thrombosis). It is also another name for myositis fibrosa, or fibrous degeneration of muscles. 8. Syphilitic gummata are firm, elastic, yellow or whitish nodular masses, varying in size from a tubercle to an orange. Their shape and outline are irregular, owing to fibrous processes which go through them ; they often have a kind of capsule consisting of fibrous-looking but trans- lucent material, which fastens them firmly to adjacent structures. On section they are mucoid or gelatinous, and vascular. Microscopically, they consist of round cells and giant cells, nuclei, fat granules and cholesterin ; around this portion will be found epithelioid cells, and an outer layer consisting of leucocytes, giant cells, and epithelioid cells. There is some intercellular material ; and blood-vessels are present. 9. Occlusion of the bile duct may be due to : Foreign bodies within the duct (gallstones, hydatids, or other parasites, inspissated bile) ; thickening of the mucosa due to inflammation, or cicatricial overgrowth of connective tissue; pressure from without (tumors, enlarged glands, aneurysm) ; adhesions, due to peritonitis.* 10. A cyst is a circumscribed cavity containing liquid or pultaceous material. Cysts may be formed: (1) By the accumulation of secretions and other products within cavities which are already in existence; and (2) inde- pendently, by the softening or liquefaction of tissues. 542 MEDICAL RECORD Varieties: Retention cysts, dilatation cysts, exudation cysts, extravasation cysts, parasitic cysts, congenital cysts, dermoid cysts. PHYSICAL DIAGNOSIS. i. See French's "Practice of Medicine" (1907), page 579; or Osier's "Practice of Medicine" (1909), page 807. 2. See French's "Practice of Medicine" (1907), page 560; or Osier's "Practice of Medicine" (1909), pages 777 and 779. 3. See French's "Practice of Medicine" (1907), pages 630 to 633; or Osier's "Practice of Medicine" (1909), pages 857 to 861. 4. A complete physiological revolution of the heart or cardiac cycle includes all the changes which occur between the commencement of one heart-beat and the commence- ment of the next; it consists of the alternate contractions (or systole) and relaxations (or diastole) of the auricles and ventricles of the heart. The contraction of the two auricles takes place simultaneously and is followed by the simultaneous contraction of the two ventricles ; then fol- lows a period during which the whole heart is in a state of diastole. The cycle then begins again with the auricular systole. 5. Rude Respiration is a form of breathing which is neither bronchial nor vesicular, but partakes of the charac- teristics of both ; it is generally called bronchovesicular breathing. Bronchial Respiration is chaacterized W t absence of the vesicular quality. Inspiration is high pitched and tubular; expiration is higher pitched and prolonged ; the two are separated by a short interval. Cavernous Respiration is a blowing sound, but constant, heard during both inspiration and expiration, lower in pitch than bronchial respiration, and hollow in character. Amphoric Respiration is a blowing respiration, of metallic or musical quality; it is present in inspiration and expiration. 6. Pulmonary tuberculosis is classified as an infectious disease. The positive diagnostic sign is the finding of the tubercle bacilli in the sputum. See above, Pathology, Question 6. 7. Test for Blood. — To the urine add a solution of potassium hydroxide to distinct alkaline reaction; heat nearly to boiling (do not boil). A red precipitate is pro- duced. 8. See French's "Practice of Medicine" (1907), page 792; or Osier's "Practice of Medicine" (1909), page 514. 9. This question is not intelligible. 10. See Rose and Carless' "Surgery" (1908), page 882. 543 MEDICAL RECORD. THEORY AND PRACTICE OF MEDICINii. i. (a) A Collyrium: I£ Atropine sulphatis, gr. ij. Sodii chloridi, er. ij. Aquae destillatae, 3ss. Misce. Signa : One drop to be placed in the eye every night. (b) A Suppository: $. Cocainae hydrochloride gr. ij. Aquae destillatae, 11$ vj. Olei theobromatis, 3jss. Misce. Fiant suppositoria No. vj. Signa: Insert one night and morning. (c) A Mouth Wash: ]£ Thymol, gr. vij. Spiritus chloroformi, 3vj. Spiritus menthae piperitae, 3ij. Tincturae hamamelidis q.s. ad %iv. Misce. Signa: One teaspoonful to be added to two table- spoonfuls of water, and used after each meal. 2. For Erysipelas: # Ichthyol, Sss. Olei citronellae, Vtyxx. Adipis, SJ- M. Signa : Apply as directed. For Rhus Tqxicodendron Poisoning: ]£ Fluidextracti grindeliae robustae, 3j. Aquae, 3x. M. Signa: Apply as directed. For Night Sweats of Phthisis: ]£ Acidi camphorici, 3iv. Alcohol, 3ij- Mucilaginis acaciae, Jiij. Syrupi aurantii corticis, q.s. ad Jvj. M. Signa: One dessertspoonful one hour before sweat is expected. For Ascites: 5 Pulveris digitalis. Pulveris scillae, aa Gr. xx. M. Fiat massa in pilulas No. xx. dividenda. Signa : One every five hours. For Ptyalism: 5 Atropinae sulphatis, gr. ss. Sacchari lactis, 3j. M. Ft. in caps. No. L. Signa: One after each meal. 3. Leucocytosis occurs in: Cholera, relapsing fever, typhus, scarlet fever, diphtheria, tonsillitis, syphilis, erysipe- 544 MEDICAL RECORD. las, bubonic plague, pneumonia, smallpox, malignant endo- carditis, septicemic conditions, actinomycosis, glanders, rheumatism, meningitis, affections of gall-bladder, pan- creatitis, endometritis, gonorrhea, abscesses, carbuncle, furuncle, appendicitis, pyonephrosis osteomyelitis salpin- gitis, inflammations of serous membranes, many inflam- matory skin diseases, and in many cases of poisonings. Leukocytosis is absent in: Typhoid, malaria, influenza, measles, rotheln, and tuberculosis. (From Cabot's Exam- ination of the Bloody 4. See French's "Practice of Medicine" (1907), pages 658 and 661; or Osier's "Practice of Medicine" (1909), pages 609 and 612. 5. See French's "Practice of Medicine" (1907), page 113; or Osier's "Practice of Medicine" (1909), page 100. 6. (a) Rubeola: Character of eruption, small, dark red papules with crescentic borders, beginning on face and rapidly spreading over the entire body; desquamation is branny. The eruption is dark, not uniform, shotty. (b) Rubella: The rash is more diffuse, and is of a rose-red color, is brighter, and less crescentic than in measles. It appears on first day, is most intense on second day, consists of red papules, often fades from face before it is seen on the limbs. (c) Scarlatina: A scarlet punctate rash, beginning on neck and chest, then covering face and body; desquama- tion is scaly or in flakes. The eruption is brighter, is on a red background, punctiform, and is more uniform. (d) Varicella: The eruption usually appears first on the trunk, is evident on the first day, comes in successive crops, is not shotty, and disappears on stretching the skin; the spots are unilocular, and collapse on being punc- tured. 7. See French's "Practice of Medicine" (1907), page 782; or Osier's "Practice of Medicine" (1909), page 507. 8. In renal colic: The pain is in the reigon of the af- fected kidney; it radiates down the thigh; there are in- tense rigors; retraction of the testicle may be present; also history of previous attacks or of calculi; the urine may be scanty, suppressed, or bloody. In hepatic colic: The pain is in the region of the liver; it radiates to the right scapula and toward the umbilicus; chills and sweats are common; also vomiting, and some- times symptoms of collapse and jaundice; calculi are found, if at all, in the feces. 9. See Osier's "Practise of Medicine" (1909), page 547. 10. See French's "Practice of Medicine" (1907), page 969; or Osier's "Practice of Medicine" (1909), page 385. 545 MEDICAL RECORD. OBSTETRICS AND HYGIENE. I. FOOT. This is at right angles to the leg. The inner border is thicker than the outer. The toes are short and are in a straight line. The great toe cannot be altered in its relation to the remaining toes. The toes cannot be sepa- rated to any great extent. The malleoli and heel (projecting os calcis) may be felt. The ankle-joint is not freely movable. HAND. This is a straight line with the arm. Both borders are of equal thickness. The fingers are longer, and the thumb is at right angles to the other digits. The thumb may be bent across the palm, and thus brought into contact with the other fingers. The thumb and first finger may be considerably sepa- rated. There is an absence of such features. The wrist joint is quite movable. — (Dorland's Obstetrics.) For treatment, see Williams' "Obstetrics" (1909), page 802. 2. The bag of water is the amniotic sac with the liquor amnii; this latter is alkaline in reaction, has a specific gravity of about 1.001 to 1.008, its quantity is variable, but is generally about two pints. It consists chiefly of water, but contains small amounts of albumin, epithelial cells, urea, phosphates, chlorides, etc. Its source is unsettled. Functions. — (a) During pregnancy: (1) As a protection to the fetus against pressure and shocks from without. (2) As a protection to the uterus from excessive fetal move- ments. (3) It distends the uterus, and thus allows for the growth and movements of the fetus. (4) It receives the excretions of the fetus. (5) It surrounds the fetus with a medium of equable temperature, and serves to pre- vent loss of heat. (6) It prevents the formation of ad- hesions between the fetus and the walls of the amniotic sac. (7) It has been supposed, by some, to afford some slight nutrition to the fetus. (b) During labor: It acts as a fluid wedge, and dilates the os uteri and the cervix ; it also slightly lubricates the parts. 3. See Williams' "Obstetrics" (1909), page 664. 4. Symptoms of death of the fetus during the later months of pregnancy are : Cessation of the signs of preg- nancy, the abdomen and uterus are both diminished in size, 546 MEDICAL RECORD. the fetal heart sounds and movements cease, there is no pulsation in the cord, the mother's breasts become flaccid and occasionally secrete milk. If the fetus has been dead for some time, crepitus of its cranial bones may be elicited. Treatment: Abortion or premature labor must be in- duced, and the contents of the uterus removed immediately. 5. See Williams' "Obstetrics" (1909), page 128; or Hirst's "Obstetrics" (1909), page 120. 6. (a) To report all cases of infectious and contagious diseases ; to effect a temporary quarantine on these same cases ; to report all births and deaths occurring in their practice, (b) All infectious and contagious diseases. 7. The dangers of cold-storage foods are : The keep- ing quality of the food is impaired, and so the food must be consumed soon after it leaves the cold storage; danger may lurk in the ice, particularly when not made from pure water; a similar danger exists when food is put in dirty water and surrounded by ice ; ptomaine poisoning may occur; typhoid bacilli may retain their vitality even in water at the freezing point. 8. "The continued use of tobacco, by smoking or chew- ing it to excess, produces granular inflammation of the fauces and pharynx, atrophy of the retina, dyspepsia, low- ered sexual power, sudden faints, nervous depression, car- diac irritability, and occasionally angina pectoris. Used by the young, it hinders the development of the higher nerve centers and impairs the nutrition of the body by interfer- ing with processes of digestion and assimilation. It has been credited with causing cancer of the lips and tongue, blunting the moral sense, mental aberration, and even in- sanity."— ( Potters' Materia Medica.) 9. See French's "Practice of Medicine" (1907), page 108; or Osier's "Practice of Medicine" (1909), page 97. 10. (a) About 65 to 70 ounces of water should be drunk in a day, besides about 20 ounces taken in as an ingredient of solid food. (b)The chief sources of contamination of drinking water are : Sewage, including not only solid and liquid excreta, but also house water and waste water; manufacturing refuse, such as from dye works, bleaching works, tanneries, and numerous other industrial places; from improper storage or service of water, (c) The presence of organic matter is shown by the change of color which occurs in a pink solution of potassium per- manganate; it loses oxygen and becomes brownish. GYNECOLOGY. 1. Endometritis: The acute form is due to the introduc- tion of septic bacteria, and is manifested by pain, consti- pation, irritability of bladder, rapid pulse, rise of tempera- ture, and a profuse discharge. Treatment following mis- 547 MEDICAL RECORD. carriage or labor consist's in curettage, intrauterine hot sterile douche, free purgation, hot over the lower abdomen, milk diet, and stimulants. Chronic endometritis may ac- company numerous pathological uterine conditions, but is generally due to gonorrhea. The symptoms are backache, headache, leucorrhea, profuse menstruation, and impair- ment of the general health. Treatment consists in re- moving the cause when possible, and when due to gonor- rhea curettage and ' irrigation of the uterus, with the appli- cation of an antiseptic. 2. Atresia of the vagina is an obstruction of the vagina by adhesion (either congenital or acquired). Treatment: Adhesions are to be separated, bands cut off short, cicatri- cial tissue dissected out, the wound closed, and a dilator inserted into the vagina. 3. Most frequent causes of pyosalpinx are : Gonorrhea, puerperal septic endometritis, and sepsis from use of dirty instruments. It is diagnosed by: Pain or discomfort, made worse by pressure, examination, or defecation; or colicky pains over the tube; dysmenorrhea; increased men- strual flow; tubes are found to be dilated and swollen. Treatment : Removal of the affected tube. 4. MenorrMgia is an excessive loss of blood at the men- strual periods. Metrorrhagia is a hemorrhage from the uterus at other than the menstrual periods. It is very often impossible to differentiate the two conditions. Treatment: Remove the cause, if possible; treat abnormal conditions that are present; vaginal douches, tampons, and curettage have been recommended; also ergot, hamamelis, hydrastis, and viburnum prunif olium ; rest in bed is necessary. In- trauterine applications of astringents or of adrenalin have been used. Amenorrhea is absence of menstruation during the oeriod of sexual activity. Treatment consists in: (1) Removing the cause, if possible; (2) general treatment by means of proper hygiene, rest, diet, bathing, attention to the bowels, exercise, etc.; (3) drugs reouted to be em- menagogues such as^ iron, manganese, aloes, strychnine, apiol, oxalic acid, savine, rue, and tansy. 5. Prolapsus uteri. Treatment: "Operative, unless some contraindication to operation exists. In such a case some mechanic device should be tried for the support of the uterus. Pessaries are not to be recommended, as their constant use leads to irritation and excoriation of the vaginal walls. Probably the best means for supporting the uterus is by Braun's colpeurynter. This is worn only during the day, and can be introduced by the patient her- self every morning. The uterus is replaced and the col- peurynter well anointed with carbolized vaseline and con- taining about an ounce of water, is introduced into the va- gina. It is then distended with air, thus making an even 548 MEDICAL RECORD. pressure on the vaginal walls and not causing ulcerations. Operative treatment gives the most satisfactory results in prolapse. In slight cases of prolapse repair of the peri- neum will effect a cure. The severer grades will require, in addition, some operation on the anterior vagina. The best of these is Martin's operation for cystocele. If the cervix is hypertrophied it should be amputated. Three operations — on the perineum, for cystocele, and amputation of the cervix — are required in the usual case of prolapse. In addition, hystrorrhaphy may be advisable, since there can be no prolapse so long as the uterus maintains its nor- mal position of anteflexion. These onerations failing, hysterectomy may be performed." 6. In ovaritis: The ovary is increased in size; is tender on pressure, and pressure causes a sickening sensation; is generally displaced (backward) ; dyspareunia and hysteria may be present. In cystic ovary: The condition is gener- ally unilateral, not often adherent, may grow to be very large size. In salpingitis; Both tubes are apt to be af- fected, the tube is oblong and generally adherent, ovary may be palpated as distinct from the tumor- usually it is not very large, and there may be leucocytosis. 7. See Williams' "Obstetrics" (1909), pages 644 and 649; or Hirst's "Obstetrics" (iox | 9), pages 303 and 306. 8. See Williams' "Obstetrics" (1909), page 26; or Hirst's "Obstetrics" (1909), page 43. SANITARY SCIENCE. i. Concerning schools: The school building should be as near as possible to the center of the area which it is to serve; the site should be airy and open, of sufficient size, free from swamps, and somewhat elevated ; it should not be too near factories, busy streets, or railways; the soil should be as free as possible from organic matter. The building should be so planned that the corners look towards the four points of the compass. In this way the sun will have access to each side and to every room during some part of the day. The building should have as few stories as possible. The walls should be of brick or stone, and should be pointed with cement; the inner surface of the wall should be cemented smooth. The foundations must be solid. The general arrangement will depend upon size of site, number of scholars, and number of required rooms. Fifteen square feet per child should be allowed. Details will have to be considered on: plans, accommo- dations to be provided, shape and size of class rooms, distribution of rooms, teachers' rooms, corridors, entrances and staircases, playground, ventilation, heating, lighting, and placing of windows, sanitation, lavatories water sup- ply, drinking water, sewage disposal, removal of refuse, sanitary appliances, and drainage. Special care must be 549 MEDICAL RECORD. given to the prevention of contagious diseases, and the ex- clusion of all possible sources of infection or contagion; there should be physical examination of children, also, for non-contagious physical defects. Concerning water supply: This must be free from ex- creta of human beings and animals ; and the intake must be a sufficient distance from any possible source of pollu- tion by sewage or other impurities. If the water comes from a source which cannot be controlled by inspection, sand filtration or other means of purification must be used. Concerning sewerage: This should not be deposited into water which may be the source of supply for any town. For small towns, sedimentation and filtration (or some other recognized method) should be adopted. 2. The main thing is the prevention and check of con- tagious diseases by isolation, quarantine, and subsequent disinfection. There must be a sufficiency of water, and adequate inspection of the source of its supply; examina- tion of food supplies, particularly milk, and insistence that food is not exposed to dust, flies, or other deleterious influences; purity and wholesomeness of milk and water; proper sewage disposal ; adequate medical school inspec- tion ; proper laboratory facilities for production of anti- toxins and vaccines, and for early diagnosis of diphtheria, tuberculosis, typhoid, and malaria; abatement of nuisances (such as noise, smoke, odors). SURGERY. 1. See Rose and Carless' "Surgery" (1908), page 1148; or Da Costa's "Surgery" (1908), page 1012. 2. In osteomyelitis: There are sudden onset, pain, chills, fever, tenderness, swelling of soft parts, sometimes the joint can be moved gently without pain; septicemia or pyemia may be present. In rheumatism there is succes- sive involvement of many joints; the tenderness, pain, and swelling are over the joints, and not over the bones; pro- fuse sweats are present, and the condition responds to treatment by salicylates. In osteomyelitis the treatment consists in relieving the constitutional symptoms and preventing the bone < from necrosing. An incision down to the bone is made; if pus is beneath the periosteum, the latter is also incised; a piece of bone is removed by chisel or trephine, pus is removed, the endosteum is hurt as little as possible, the wound is irrigated with hot bichloride solution and packed with gauze; the soft parts are closed and the wound well drained. In case this fails, amputation mav be necessary. 3. See Rose and Carless' "Surgery" (1908), page 915; or Da Costa's "Surgery" (1908, oa^ 769. 4. See Rose and Carless' "Surgery" (1908), pages 1099 and 1103; or Da Costa's "Surgery" (1908), page 992. 550 MEDICAL RECORD. 5. See Rose and Carless' "Surgery" (1908), page 340; or Da Costa's "Surgery" (1908), page 423. 6. See Rose and Carless' "Surgery" (1908), page 638; or Da Costa's "Surgery" (1908), page 609. 7. See Rose and Carless' "Surgery" (1908), page 538; or Da Costa's "Surgery" (1908), page 515. 8. See Rose and Carless' "Surgery" (1908), passes 534 and 481; or Da Costa's "Surgery" (1908), pages 540 and 464. 9. See Rose and Carless' "Surgery" (1908), page 1161; or Da Costa's "Surgery" (1908), page 1104. 10. See Rose and Carless' "Surgery" (1908), page 1121; or Da Costa's "Surgery" (1908), pages 838 and 962. MEDICAL JURISPRUDENCE. i. In case of rape of a girl of twelve years old, one might find: (1) Marks of violence about the genitals; (2) wounds, bruises, or other marks of injury on the body; (3) bloodstains and seminal stains on the person or clothing. 2. The causes of sudden death are: Cerebral hemor- rhage; rupture of a gastric ulcer; valvular disease of the heart, especially aortic ; angina pectoris ; rupture of an aortic aneurysm; suffocation during an epileptic fit; shocks of electricity; sunstroke; mental or physical shock; diabetic coma ; uremia ; exertion on an overloaded stomach. 3. A wound inflicted during life is generally character- ized by hemorrhage, coagulation of the blood, eversion of the edges, and retraction of its sides. It may also be in- ferred that the wound was inflicted during life if any of the following are noticed : The presence of inflammation, swelling, pus, or gangrene on the edges of the wound, or if there is any sign of beginning cicatrization. 4. Rigor mortis is supposed to be due to the coagulation of the myosin in the muscles. It lasts for a variable period, generally from about sixteen to twenty-four hours. 5. Strangulation generally points to homicide; hanging, to suicide. TOXICOLOGY. 1. Antidote (for oxalic acid) is calcium carbonate, or hydroxide, or magnesia. Treatment: Give bland mucilag- inous drinks, and antidotes; do not use stomach pump. 2. Post-mortem appearances in carbolic acid poisoning: "The mouth and throat show corrosive effects. The mu- cous membrane is generally white or gray and pultaceous, or it may be hardened and corrugated. The stomach usu- ally shows relatively little corrosion. The blood is dark and fluid. All the fluids of the body exhale the odor of phenol. The bladder is empty, or contains a small quantity of dark or greenish urine. As death is usually due to asphyxia, the veins of the head and brain are congested. 551 MEDICAL RECORD. Putrefaction is apt to be retarded." — (Riley's Toxicology.) 3. Symptoms of poisoning by corrosive sublimate are : A burning pain in the mouth, pharynx, and stomach; the mouth and tongue are white; the vomitus is white, with shreds of mucous membrane, and tinged with blood; there may be bloody stools, also salivation. Treatment: The antidote is white of egg, but too much must not be given at one time ; this should be followed by an emetic. 4. The antidote for strychnine is tannic acid, or weak solution of potassium permanganate. 5. Quinine, cubebs, copaiba, belladonna, bromides, iodides, mercury, salicylic acid, arsenic, and opium. STATE BOARD EXAMINATION QUESTIONS. Board of Medical Examiners, State of Oregon. ANATOMY. 1. Give the course and distribution of the trifacial^ nerve. 2. Name and give the origin of the arteries supplying the stomach, small intestine, large intestine. 3. Give the course and branches of distribution of the femoral artery. 4. Name the structures passing beneath Pouparfs liga- ment. 5. What structures would be severed in an amputation at junction of the middle and upper thirds of the forearm? 6. Give the coverings of an incomplete oblique inguinal hernia. 7. Name and locate the various valves of the heart, and give the function of each set. 8. Name the tunics and the humors of the eye. PATHOLOGY. 1. Give pathology of a carbuncle; and how does it differ from a furuncle? 2. Define phagocytosis, metastasis, leucocytosis. 3. Give the pathological anatomy and histology of acute parenchymatous or degenerative nephritis. 4. Give the pathology of atrophic portal cirrhosis ("gin- drinker's liver") . PHYSIOLOGY. 1. What is the function of the red corpuscles? State their number and what variation with altitude. 2. Give function of white corpuscles and state under what normal conditions leucocytosis occurs. 3. Describe the lymphatic system and state what factors control lymphatic circulation. 4. Give functions of auricles and ventricles of heart, and state what is meant by systole and diastole. 552 MEDICAL RECORD. 5. Name kinds and location of digestive ferments and state their action on foods in the small intestine. 6. How prove the spinal cord a center for reflexes? 7. Give name and state what kind of nerves the sixth and eleventh cranial nerves are. What does each supply? 8. What maintains the pitch of the voice? HISTOLOGY. 1. Describe protoplasm. Does it possess structure? 2. Describe white fibrous tissue; also yellow elastic tissue, and state where found. 3. Describe in detail a lobule of the liver. 4. Where are nerve cells found? GYNECOLOGY. 1. Name three leading causes of sterility, with treatment in each case. 2. Etiology, diagnosis, and treatment of retrodisplace- ments of the uterus. 3. Give five causes of pruritus of the vulva, with treat- ment in each case.^ 4. Give diagnosis, symptomatology, and treatment of septic abortion. 5. Name two common causes of dysmenorrhea, giving diagnosis and treatment. 6. Describe a miscarriage at five months, giving treat- ment to successful conclusions. 7. Diagnose and describe operation of salpingo-oopho- rectomy for adherent tubes and ovaries. 8. Describe operation for vaginal hysterectomy. GENERAL DIAGNOSIS. i. What diseases produce conditions of the skin which are of general diagnostic value? 2. What are the grades of temperature that come under observation in the sick? 3. Give the method for the detection of the tubercle bacillus in the sputum. 4. What is the diagnostic significance of dropsy? 5. Describe the characteristics and significance of the several kinds of pulse. 6. Give the symptoms of acute meningitis. 7. What are the diagnostic points in secondary syphilis? 8. What casts are frequently found in albuminous urine, and what do they denote? NERVOUS DISEASES. i. Give symptoms of tuberculous meningitis. 2. Define and give etiology of acute ascending paralysis. 3. What symptoms would you expect to find following rupture of a branch of the middle meningeal artery? 553 MEDICAL RECORD. 4. Give definition, prognosis, and treatment of puerperal insanity. PRACTICE OF MEDICINE. 1. Give the etiology, pathology, common complications, and symptoms of typhoid fever. 2. Give the differential diagnosis of variola, varicella, scarlet fever, measles, and erysipelas. 3. State the etiology, pathology, diagnosis, and symptoms of croupous pneumonia. 4. Give the differential diagnosis of mitral regurgitation, aortic regurgitation, and aortic stenosis. 5. Give the pathology, etiology, and diagnosis of chronic interstitial nephritis. 6. Give the differential diagnosis of acute alcoholism, acute morphinism, and apoplexy. 7. State the pathology, etiology, symptoms, and treatment of ileocolitis of childhood. 8. State the pathology, etiology, and differential diagnosis of chronic gastric ulcer. PRACTICE OF SURGERY. 1. Give the mechanism, pathology, symptoms, and treat- ment, and name the ligaments injured in backward dislo- cation of the hip-joint. 2. Describe amputation at middle third of arm, and name all tissues cut. 3. Give complete preparation of patient for abdominal section. 4. Describe the operation of posterior gastroenterostomy, and name the complications that may follow. 5. Give the anatomical relations, covering of sac, and detail of operation for femoral hernia. 6. State the etiology, pathology, diagnosis, symptoms, and treatment of osteomyelitis of the tibia. 7. Name the triangles of the neck; describe the relations and ligation of the common carotid artery. 8. State the etiology, pathology, symptoms, and treat- ment of pyelitis. EYE AND EAR. i. Give the etiology, diagnosis, symptoms, indications, and describe operation for mastoid abscess. 2. Give the differential diagnosis of gonorrheal conjunc- tivitis and blepharitis ciliaris. 3. Give the etiology, diagnosis, symptoms, and treatment of acute myringitis. 4. Give the treatment and your instructions to patient with marginal corneal ulcer. 5. Give the anatomy and appearance of a normal ear drum. 554 MEDICAL RECORD. CHEMISTRY. i. Write a comprehensive definition of chemistry in not more than sixty words. 2. Define briefly the following chemical terms and name a substance that is characteristic of each: Deliquescent; efflorescent ; effervescent; fluorescent. 3. What do you consider the most practical chemical test for sugar, albumin, pus, blood, urea, in the urine? 4. Differentiate between empirical formula and graphic formula, giving as an example the formation of acetic acid. 5. Define "equation," and express the formation of mer- curous chloride by chemical equation. 6. What do you understand by the term equivalent amounts in chemistry? 7. Define molecular weight, giving an example. 8. Define specific heat and name its unit. MEDICAL JURISPRUDENCE. 1. What are the requisites of a hypothetical question, and under what circumstances may the opinion be given in evidence of (a) an expert witness, and (b) a non-expert witness? 2. What are the constituent elements of blood? How do you distinguish between the blood of mammalian verte- brates and that of oviparous vertebrates, and between the blood of different mammals? Name the different tests for blood stains, and give the principles upon which each test depends. 3. Define and describe the different kinds of wounds; how to determine whether a wound is ante- or post-mor- tem, and why. if at all, the size and shape of a wound does not always correspond to the size and shape of the instru- ment with which it was made. 4. Describe generally the proper method of conducting a post-mortem examination, giving details as to head, chest, abdomen, and spinal cord; state how you would test the lungs of a dead child to determine whether it had been born alive, and how you would recognize flotation caused by (a) artificial insufflation, (b) putrefaction, and (c) freezing. OBSTETRICS. 1. What is the conjugate and transverse diameter of the inlet and outlet of the pelvis? Give its anatomical points of measurements. 2. What is the cause of rupture of the uterus, and under what circumstances does it occur? 3. Give your treatment for inevitable abortion. 4. Give your treatment for post-partum hemorrhage. 5. .Give cause and treatment for transverse presentations. 555 MEDICAL RECORD. 6. Give cause, diagnosis, and treatment of puerperal eclampsia. 7. When would you use forceps, and how ? 8. Give the anatomy of the uterus, and state what changes take place during gestation. DISEASES OF CHILDREN. 1. Give the symptoms in morbus coxarius during the early stage of the disease. What other diseases might you differentiate it from? 2. Give the etiology and describe the pathology of hip- joint disease. 3. Give a clinical description of the various stages of rubeola. 4. Describe symptoms, prognosis, and treatment in ileo- colic intussusception. 5. Atelectasis pulmonum; what is it? Note its symptoms and treatment. 6. Describe a process of peptonizing cow's milk, suitable for infant use. 7. Describe the principal striking clinical changes that take place in the skeleton in rhachitis. 8. From what other diseases would rhachitis have to be differentiated? MATERIA MEDICA AND THERAPEUTICS. 1. Write an appropriate prescription in case of catarrhal jaundice; also two prescriptions to relieve cough in acute bronchitis. 2. Carbolic acid: origin, dose, and physiological action. Give appropriate treatment in case of poisoning. 3. What would be a suitable dietary in hyperchlorhydria, and give reason for same. 4. Apomorphine hydrochlorate : dose, physiological ac- tion, and therapeutic uses and indications. 5. Spiritus setheris nitrosi; origin, dose, therapeutic uses, and common name. 6. What is a diaphoretic? Name four agents, and appro- priate doses of each. 7. What do you understand (a) a cardiac tonic to be, and how does it act? (b) A cardiac stimulant, and how does it act? Give examples of each. 8. What are cathartics, and how do they act? Name five diseases or conditions in which the administration of a cathartic would be contraindicated. 556 MEDICAL RECORD ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Board of Medical Examiners, State of Oregon. ANATOMY. i. Superficial origin: From the side of the pons Varolii. Deep (sensory root), from the medulla and upper part of cord; (motor root) from floor of fourth ventricle and side of the aqueduct of Sylvius. Exit: The ophthalmic division, through the sphenoidal fissure; the superior max- illary division, through the foramen rotundum ; the inferior maxillary division, through the foramen ovale. Ophthalmic branch distributed to conjunctiva, skin of upper eyelid, cornea, skin of forehead, and nose, lacrymal gland. Supe- rior maxillary, to skin and conjunctiva of lower eyelid, nose, cheek, upper lip, upper teeth, and palate. Inferior maxillary, to external auditory meatus, side of head, mu- cous membrane of mouth, anterior two-thirds of tongue, lower teeth, and skin of lower part of face. Also _ to muscles as indicated under Function. It supplies sensation to all the parts mentioned above; but, in addition, Inferior maxillary supplies motion to the muscles of mastication, the mylohyoid, and anterior belly of the digastric. 2. The stomach is supplied by the gastric (from celiac axis), pyloric (from the hepatic), right gastroepiploic (from the gastroduodenal), left gastroepiploic and vasa brevia (from the splenic). The duodenum, by the pyloric and pancreaticoduodenal from the hepatic), the inferior pancreaticoduodenal (from the superior mesenteric). The rest of the small intestine, by branches of the superior mesenteric (from abdominal aorta). The large intestine, by the ileocolic, right colic, and middle colic (from the superior mesenteric) ; left colic, sigmoid, and superior hemorrhoidal (from inferior mesenteric). The rectum, by superior hemorrhoidal (from inferior mesenteric) ; middle hemorrhoidal (from internal iliac), and inferior hemorrhoidal (from internal pudic). 3. The femoral artery begins at Poupart's ligament; it is the continuation of the external iliac, and passes down the fore part and inner side of the thigh, to terminate at the opening in the adductor magnus at the junction of the middle with the lower third of the thigh, where it becomes the popliteal artery. Branches: Superficial epigastric, su- perficial circumflex iliac, superficial external pudic, deep external pudic, muscular, anastomotica magna, and pro- funda f emoris (with branches : external circumflex, inter- nal circumflex, and three perforating). 4. These are (from without inward) : External cuta- 557 MEDICAL RECORD. neous nerve, iliacus, anterior crural nerve, psoas, femoral artery, femoral vein, femoral ring. 5. In amputation of forearm at junction of middle and upper third, there will be severed: Skin, fascia, supinator longus, extensor carpi radialis, longior and brevior, exten- sor communis digitorum, extensor carpi ulnaris, supinator brevis, anconeus, pronator radii teres, flexor carpi radialis, palmaris longus, flexor sublimis digitorum, flexor carpi ulnaris, flexor profundus digitorum ; arteries : anterior interosseous, radial, ulnar; veins: radial, interosseous, ulnar, median ; nerves : posterior interosseous, radial, me- dian, ulnar ; bones : radius, ulna. 6. From without inward : Skin, superficial fascia, inter- columnar fascia, cremasteric fascia, infundibuliform fascia, subperitoneal areolar tissue, and peritoneum. 7. In the right auricle are the Eustachian and coronary valves; the former is situated between the anterior margin of the inferior vena cava and the auriculo-ventricular ori- fice; in the fetus it directs the blood from the inferior vena cava through the foramen ovale into the left auricle; the coronary valve prevents the regurgitation of blood into the coronary sinus during the auricular contraction. In the right ventricle are the tricuspid and semilunar valves; the former prevent the blood in the right ventricle from flowing back into the right auricle during ventricular systole; the latter guard the orifice of the pulmonary artery. In the left ventricle are the mitral and semilunar valves; the former acts similarly to the tricuspid; the latter guard the orifice of the aorta. Aortic valves, behind the third intercostal space, close to the left side of the sternum. Pulmonary valves, in front of the aortic, behind the junction of the third rib, on the left side, with the sternum. Tricuspid valves, behind the middle of the ster- num, about the level of the fourth costal cartilage. Mitral valves, behind the third intercostal space, about one inch to the left of the sternum. 8. Tunics:, (1) Sclerotic and cornea; (2) choroid, ciliary body, and iris; (3) the retina. Humors: (1) Aqueous humor; (2) vitreous body; (3) crystalline lens. PATHOLOGY. 1. A carbuncle is due to infection with a pus organism, which causes an acute inflammatory exudation. The dense fibrous tissue under the skin does not yield, and the com- pression strangles the vessels. Septic gangrene results from these causes. Later, the living tissues suppurate around the septic slough and form pus. The pus breaks through the overlying skin in one or two places and the slough is discharged, the cavity being filled up by granu- lation and cicatrization. A furuncle opens by a single open- ing, instead of several, and is frequently multiple. 558 MEDICAL RECORD. 2. Phagocytosis is the faculty of certain cells (notably the mononuclear and polynuclear leucocytes) to take up and destroy bacteria. Metastasis is the transfer of a morbid process from one part of the body to another not directly continuous with it. Leucocytosis is an increase in the number of white corpuscles in the peripheral blood. 3. The epithelium of the tubules, especially in the convo- luted portions, is swollen, cloudy, and considerably desqua- mated. Leucocytes and some red corpuscles are found within the tubules and the Malpighian capsule. The kidney is enlarged, somewhat swollen, and rather pale in color. The changes are most marked in the cortex, which is thicker than normal. The capsule strips easily. 4. The liver is shrunken and indurated, rough, and of a pale or yellow color ; a growth of new connective tissue is disposed in broad bands which run in various directions, and by their contraction divide the liver into numerous irregular lobes. Many acini may be affected at one time. The capsule may be thickened, or adherent to the dia- phragm. Jaundice is slight, and comes on late ; ascites is pronounced and may occur early. PHYSIOLOGY. 1. The function of the red corpuscles is to supply the tissues with oxygen. There are about 4,500,000 to 5,000,000 to the cubic millimeter of blood. Altitude causes an in- crease in their number. 2. The white corpuscles serve as a protection against pathogenic microorganisms ; they take some part in the process of the coagulation of the blood ; they aid in the absorption of fats and peptones from the intestine, and they help to maintain the proper proteid content of the blood plasma. Leucocytosis occurs normally during diges- tion, after exercise, during pregnancy, and the puerperium, in the newborn, and just before death. 3. The lymphatic system consists of: lymphatic glands, lymph vessels, perivascular lymph spaces, the lymph canal- icular system, the pericardial, pleural, peritoneal, and syno- vial cavities, and the lacteals. The forces concerned in the circulation of the lymph are: The pressure of the blood in the blood-vessels; thoracic aspiration; contractions of the voluntary muscles ; contractions of the intestine ; the action of the valves in the lacteals and lymphatics. 4. The function of the auricles is to receive the blood from the body and from the lungs. That of the ventricles is to send the blood to all parts of the body and to the lungs. Systole is that period when the ventricles (or auricles) are contracting. Diastole is that period when the ventricles (or auricles) are not contracting, but are at rest, and receiving blood. 559 MEDICAL RECORD. DIGESTIVE FERMENTS ORIGIN FUNCTIONS Ptyalin. Saliva. Changes starches into dextrin and sugar. Pepsin. Gastric juice. Changes proteids into proteoses and peptones in an acid medium. A curdling ferment. Gastric juice. Curdles the casein of milk. Trypsin. Pancreatic juice. Changes proteids into proteoses and peptones, and afterward decomposes them into leucin and tyrosin in an alkaline medium. Amylopsin. Pancreatic juice. Converts starches into maltose. Steapsin. Pancreatic juice. Emulsifies and sa- ponifies fats. A curdling ferment. Pancreatic juise. Curdles the casein of milk. Invertin. Succus entericus. Converts maltose into glucose. 6. The fact that parturition can occur in a woman when under the influence of an anesthetic shows that the center of the movement of the uterus is in the spinal cord, and not in the brain. 7. The sixth cranial nerve is the abducens; it is the motor nerve to the external rectus muscle of the eye. The eleventh cranial nerve is the spinal accessory; it is a motor nerve. 8. The pitch of the voice depends upon the number of vibrations and the length of the vocal cords during a given time, and is maintained by the state of tension of the vocal cords. HISTOLOGY. 1. Protoplasm is an unstable albuminoid substance, viscid, and generally colorless. It consists of a fibrous network and a more fluid portion, which fills the meshes of the former. Views differ as to the structure of protoplasm. 2. White fibrous tissue is made of glistening fibers covered with loose flocculent tissue. It has no elasticity, very little extensibility, but very great strength. In liga- ment and tendons the bundles are parallel with each other; 560 MEDICAL RECORD. in membranes, they intersect each other at various planes. The cells are situated on the surface of groups of bundles, are arranged in single file and joined by cement substance. It is found in ligaments, tendons, muscular fascia, perios- teum, perichondrium, pericardium, dura mater, sclerotic coat of eye, tumica albuginea of testis, epineurium. Yellow elastic tissue is of yellowish color, is very elastic, and has but little of the fibrous variety. It consists of fibers with curling ends and of well-defined outline; these are larger than the white fibrous kind. It is found in Ligamenta subflava, vocal cords, trachea, bronchi, larynx, blood- vessels, thyrohyoid, cricothyroid, and stylohyoid ligaments. 3. A lobule of the liver is about 1-20 to 1-12 inch in diameter. It has a darkish red center and a lighter cir- cumference. The center is occupied by an intralobular vein which collects the blood from the capillaries of the lobule, and flows into the sublobular vein, which latter opens into the hepatic vein. Around the lobules are the interlobular veins; these are branches of the portal sys- tem; capillaries passing from the circumference to the center of the lobule connect the interlobular and intra- lobular veins. Between the network of capillaries in the lobule the hepatic cells are packed. 4. In the gray matter of the brain and spinal cord sym- pathetic ganglia, ganglia on cerebrospinal nerves, and in the organs of special sense. GYNECOLOGY. i. (1) Absence of, or errors in development of, any part of the genital tract. Treatment: Little or nothing can be done; atresia of the crevix can be treated by dila- tation. (2) Malpositions of the uterus. Treatment: Re- placement. (3) Membranous dysmenorrhea. Treatment: Dilatation of cervix and curettage. 2. Retroflexion. Etiology: Tight lacing and tight cloth- ing; congenital conditions; pressure by tumors; metrititis and parametritis with adhesions; atonic conditions of the uterus following labor ; and the conditions that cause retro- version. Diagnosis: The cervix is low in the pelvis; the fundus is in the cul de sac of Douglas ; bimanual examina- tion will show the flexion. Treatment: If there are no adhesions, the flexion should be corrected by digital manip- ulation and a pessary introduced; hysteropexy may be necessary. Retroversion. Etiology: Relaxation of uterine liga- ments; increased weight of fundus; subinvolution; ova- rian or other tumor pressing on front of uterus ; distended bladder; peritonitis or cystitis; prolonged dorsal decubitus and tight bandaging in the puerperium. Diagnosis: Con- joined manipulation will show the cervix displaced toward 56i MEDICAL RECORD. the pubes, and the body of the uterus in the hollow of the sacrum. Treatment: Remove the cause, if possible; re- place the uterus and keep it in position by pessaries, tam- pons, and knee-chest position; pelvic massage and vaginal douches; proper hygiene, particular attention being paid to the bowels, clothing, and exercise. Curative treatment: The choice lies between ventral suspension of the uterus and shortening of the round ligament. 3. Parasites, diseases of the vulva, irritating discharges, diabetic urine; it may also be of nervous origin, or idio- pathic. Treatment consists in removing the cause, if pos- sible ; cleanliness, fresh air, tonics, and general attention to hygiene; local applications of solution of bichloride of mercury, 1:2,000; or carbolic acid, 1:100; or lead and opium; dusting powders of bismuth subnitrate, calomel, or zinc oxide are also useful. 4. Septic abortion shows chili, followed by high temper- ature and rapid pulse; lochia is first diminished or sup- pressed, later returns and is dark, purulent, and has an offensive odor; uterine pains, suppression of urine, ex- haustion, and typhoid state are present. The symptoms usually come on in from one day to a week after the operation. The diagnosis is made by the history of the case and the symptoms. Treatment : Uterine douche of corrosive sublimate (1:2,000), two or three times at inter- vals of eight hours, followed by hot normal salt solution. If there is no immediate improvement, curettage is indi- cated. If the symptoms are severe, curettage should be done at once, and the douching take place subsequently. The vagina is douched twice a day with corrosive subli- mate and saline solutions, as above. If the symptoms do not subside, the intrauterine douche or curettage may be repeated. 5. Dysmenorrhea may be due to: (1) Anteflexion of uterus; for treatment, see above, No. 2. (2) Tumors, such as fibroids ; treatment consists in removal of the tumor. 6. In a miscarriage at five months there will be profuse hemorrhage ; severe cramp-like pains, like labor pains ; rupture of membranes, and escape of liquor amnii, and the fetus will be expelled. There will be a history of preg- nancy and the signs of the same. The patient should be put to bed and the case in general be managed the same as if it had been a labor at full term. 7. Salpingo-oophoritis. When adhesions bind together the tube, ovary, and adjacent peritoneum, these parts form a lump, the component parts of which cannot be distin- guished without opening the abdomen. All the symptoms may be caused by other diseases ; sometimes there are no symptoms, but this is exceptional. There is pain, referred principally to the lower abdomen, lessened slightly by 562 MEDICAL RECORD. lying down ; it is aggravated by defecation, exertion, and sexual intercourse. Menstruation is generally profuse, irregular, and painful. Micturition is frequent and painful. The general health is poor, and anorexia, nausea, insom- nia, and neurasthenia may be present. If both sides are affected, sterility results. The uterus alone can be felt bimanually, the other parts constituting a thickened mass on either side or behind the uterus. Operation of salpingo-oophorectomy : "(i) Perform a median abdominal section — control hemorrhage — and re- tract lips of abdominal wound. (2) Pass the first and second ringers into the wound, with the back of the hand to the abdomen; follow down the under surface of the abdominal parietes to the symphysis, thence down on to the bladder and uterus, and thence out laterally over the superior cornu of the uterus, with the palm of the hand still downward, to and along the broad ligament, along the posterior superior aspect of which the Fallopian tube is found, and, just posterior to the tube, the ovary. These structures are drawn toward the median line into an accessible position in the abdominal wound. (3) The ova- wan artery and veins are first tied, with silk, the ligature being carried, upon a laterally curved aneurysm needle, through the clear space of the broad ligament and tied over the top of the infundibulopelvic ligament, outside of the fimbriated end of the Fallopian tube, and close to the brim of the pelvis. (4) The uteroovarian ligament, lying behind the Fallopian tube, is ligated with chromic gut, rather nearer the uterus, carried upon a laterally curved aneurysm needle. (5) The inner end of the Fallopian tube and the upper free part of the broad ligament are ligated with silk near the horn of the uterus — which ligature also controls the branches from the uterine artery. (6) The structures are now removed by cutting through the broad ligament well within the outer ligature of the ovarian vessels — and cutting through the Fallopian tube and ova- rian ligament well to the outer side of their ligatures — and carrying the incision through the broad ligament well below the hilum of the ovary. Any doubtful ligature is strengthened, and any bleeding point is surrounded by an additional gut ligature. (7) The edges of the anterior and posterior layers of the broad ligament, left by the removal of the above structures, are sutured together with gut. The patient is lowered to the horizontal position and the intes- tines and omentum are replaced. (8) The abdomen is closed, as after median abdominal section/' — (Bickham's Operative Surgery.) 8. Vaginal hysterectomy: "The patient is catheterized and placed in the lithotomy position and the external geni- tals, are thoroughly disinfected. The vagina is held open 563 MEDICAL RECORD. by broad retractors and the uterus is pulled down by vol- sella forceps grasping the cervix, while the adjoining mu- cous membrane is cut well clear of the disease by blunt- pointed scissors. Keeping close to the uterus, the dissec- tion is continued on its anterior and posterior surface by the tip of the finger and short snips of the scissors, but at the sides, after division of the mucous membrane, the cellular tissue is simply pushed up as high as possible, or till the pulsations of the uterine artery are felt. The finger is finally thrust through the uterovesical fold of perito- neum, and after cleansing the vagina flat sponges are poked in around the uterus. Douglas's pouch is entered in the same manner, hemorrhage from the vaginal wound being controlled by a few catgut sutures through its cut edges, and then the finger is^ hooked over the fundus, pull- ing it down into the posterior opening and thus bringing within reach the upper border of the broad ligaments, which are seized by long-bladed clamps and divided on the uterine side. Other clamps are placed on the remaining tissues close to the uterus, which is then excised.— (Stim- son's Operative Surgery.) GENERAL DIAGNOSIS. 1. Syphilis, erysipelas, measles, scarlet fever, smallpox, chickenpox, typhoid fever, typhus fever, yellow fever, jaundice, purpura hemorrhagica. Addison's disease, argyria, chlorosis, anemia, various drug eruptions, and skin diseases. 2. Subnormal temperature, below 97.50; normal, 97.5 to 99.5; subfebrile, 99.5 to 100.5; slight fever, 100.5 to 101.5; moderate fever, 101.5 to 103; high fever, 103 to 105, hyper- pyrexia, above 106. 3. The sputum must be recent, free from particles of food or other foreign matter; select a cheesy-looking nodule and smear it on a slide, making the smear as thin as possible. Then cover it with some carbolfuchsin, and let it steam over a small flame for about two minutes, care being taken that it does not boil. Wash it thoroughly in water and then decolorize by immersing it in a solution of any dilute mineral acid for about a minute. Then make a contrast stain with solution of Loeffler's methylene blue for about a minute; wash it again and examine with oil immersion lens. The tubercle bacilli will appear as thin red rods, while all other bacteria will appear blue. 4. Dropsy may indicate obstruction of the portal circu- lation, cardiac or pulmonary diseases, disease of the peri- toneum, diseases of the kidneys, anemia, debility, exposure to cold or wet, cancer, syphilis. 5. (1) Frequent pulse: In fevers, exophthalmic goiter, early phthisis, heart disease, anemia, chlorosis, locomotor 564 MEDICAL RECORD. ataxia, abuse of alcohol, tea, coffee. (2) Slow pulse: In cardiac disease, cerebral tumor or hemorrhage, meningitis, myxedema, epilepsy, some poisons, digestive disorders. (3) Intermittent pulse: In cardiac disease, fevers, poisons, neurasthenia, cerebral troubles, digestive disturbances. (4) High tension pulse: In arteriosclerosis, gout, diabetes, contracted kidney. (5) Low tension pulse: In fevers, anemia. 6. Sudden onset ; very severe pains in neck, back of head and spine; head is strongly retracted, causing opis- thotonos ; Kernig's sign (inability to straighten the leg when the patient is lying down and the thigh flexed at right angle to the body) ; delirium may be present; and in the cerebrospinal fluid there may be found the Diplococcus intracellular is of Weichselbaum, or the Streptococcus pyogenes. 7. The skin eruptions, or syphilides (characterized by not itching, by being of a coppery or raw ham color; gen- erally symmetrical ; painless ; by polymorphism) ; mucous patches; sore throat; condylomata; alopecia; iritis; perios- titis. 8. Hyaline casts occur in all forms of nephritis, in con- gestion of the kidneys, in jaundice; waxy casts, in chronic parenchymatous nephritis ; epithelial casts, in acute paren- chymatous nephritis; granular casts, in chronic nephritis and in acute nephritis ; fatty casts, in chronic parenchy- matous nephritis ; blood casts, in hemorrhagic nephritis ; pus and bacterial casts, in suppurative nephritis. NERVOUS DISEASES. i. In addition to the symptom of ordinary meningitis (see above, Diagnosis, Xo. 6), there is frequently tubercu- losis in other parts of the body. The onset is sudden, and there is the hydrocephalic cry. The pulse is first rapid, then slow and irregular, the respirations irregular and sighing, and the pupils are generally contracted. In the second stage there are constipation, retraction of the abdo- men, stupor, and irregular pupils. The temperature ranges from 101 to 103 F. Later there may be various paralyses, diarrhea may replace constipation, and the symptoms be- come typhoid in character. 2. Acute ascending paralysis is an acute disease char- acterized by a motor paralysis beginning in the feet and legs, rapidly extending to the trunk and arms, and finally involving the muscles of respiration and deglutition. The cause is unknown. It has been asserted to be a peripheral neuritis, of infectious origin, or a functional disorder whose anatomical basis is unknown. 3. A period of unconsciousness followed by hemiplegia and convulsions, pupils dilated on side of lesion, stupor or 565 MEDICAL RECORD coma, slow and labored breathing, slow and full pulse, vomiting, aphasia, hemianesthesia, loss ,of -control of sphincters, increased reflexes. 4. Puerperal insanity is insanity following childbirth. Patients recover, but the prognosis for life is better than that for recovery. Treatment should be directed to the patient's general condition; food, rest, sleep, and strength- ening medicines are particularly indicated. Good nursing, constant watchfulness, and tact are essential. The bowels and bladder must be regularly evacuated, and care should be taken to prevent bedsores. PRACTICE OF MEDICINE. 1/ Typhoid fever. The bacillus of Eberth is the patho- genic microorganism of the disease; it is conveyed by con- taminated food or water. In the first stage Peyer's patches become swollen, hyperemic, and reddened; a few days later they appear as whitish or gray elevations, and the hyperemia has disappeared; the surface of the patch is smooth and its edge is sharply defined; after the first week necrosis may occur; the necrotic portion falls off, leaving an irregular ulcer with undermined edges. These ulcers are elongated, with the long axis parallel with that of the intestine ; they may heal or go on to perforation. The spleen becomes congested and enlarged, is liable to infarction; the liver is enlarged; the heart becomes soft and flabby. Common complications: Hemorrhage or per- foration of bowel, peritonitis, thrombosis, meningitis, pneu- monia. Symptoms: Insidious onset, weakness, headache, epistaxis, vague pains. The temperature rises gradually, about 2 in the evening, and falling i° in the morning. Diarrhea, tenderness in the right iliac fossa, enlarged spleen, and a characteristic rash which appears from sev- enth to twelfth day. During the second week the tempera- ture remains at a uniform level ; typhoid state and de- lirium may be present. The pulse becomes rapid, weak, and dicrotic ; the heart sounds are feeble ; the tongue is coated, fissured, and tremulous; sordes appear on the teeth ; the abdomen is distended ; the stools are yellowish and offensive (said to be like pea soup) ; the Widal # reac- tion may be positive. In the fourth week the temperature becomes normal. 2. Variola: The eruption usually appears first on the forehead and wrists, and on the third or fourth day ; it is first macular, then papular, then vesicular, and finally pustular; it does not appear in successive crops; the spots are multilocular, and do not collapse on being punctured; the papule is hard and shotty, and does not disappear on stretching the skin. Varicella: The eruption usually ap- pears first on the trunk, is evident on the first day, 566 MEDICAL RECORD. comes in successive crops, is not shotty, and disapppears on stretching the skin ; the spots are unilocular, and col- lapse on being punctured. Scarlet fever: Period of incu- bation, from a few hours to seven days. Stage of inva- sion, twenty-four hours. Character of eruption, a scarlet punctate rash, beginning on neck and chest, then cover- ing face and body; desquamation is scaly or in flakes. The eruption is brighter, is on a red background, punctiform, and is more uniform ; the temperature is higher, the pulse quicker; the tongue is of the "strawberry" type, the lymphatics in the neck may be swollen, and there is sore throat; Koplik's spots are absent. Measles: Period of in- cubation, ten to twelve days. Stage of invasion, four days. Character of eruption, small, dark red papules with cres- centic borders, beginning on face and rapidly spreading over the entire body; desquamation is branny. The erup- tion is darker, less uniform, more shotty; the temperature is lower, pulse slower, the tongue is not of the "straw- berry" type; coryza, coughing, and sneezing may be pres- ent; Koplik's spots are present. Erysipelas is characterized by: A rise of temperature; a tendency to spread; the skin is swollen and the affected part has a well-defined border and raised margins ; the rash is local, not punctate, but bullous; there are pain, considerable constitutional disturb- ance, and a possibility of infection. 3. See French's Practice of Medicine (1907), pages 151 et seq.; or Osier's Practice of Medicine (1909), pages 164 et seq. 4. In mitral regurgitation there is a systolic murmur, heard loudest at the apex, transmitted toward the left axilla, and often heard at the angle of the left scapula. The heart is enlarged. In aortic regurgitation there is a diastolic murmur, heard loudest at the second interspace, transmitted down the sternum. The left ventricle is hyper- trophied. There will also be present Corrigan's pulse, and pulsating arteries in the neck. In aortic stenosis: A sys- tolic murmur heard over the aortic area, transmitted into the carotids, and usually accompanied by a loud first sound. Hypertrophy of the left ventricle, increased area of cardiac dullness, apex beat is displaced downward and to the left, the pulse is generally small and infrequent. 5. See French's Practice of Medicine (1907), pages 901 et seq.; or Osier's Practice of Medicine (1909), pages 694 et seq. 6. In acute alcoholism the coma is not usually absolute; there may be an odor of alcohol on the breath, the patient can generally be aroused by shouting in his ear; there is no paralysis; the pupils are normal or dilated; respiration is practically normal ; the pulse is first rapid and later feeble, and the skin cool. In acute morphinism the pupils 567 MEDICAL RECORD. are contracted, there is no sign of paralysis; both respira- tions and pulse are slow and full. In apoplexy there is generally paralysis of the head and upper limbs, and in left-sided lesions there may be aphasia; the pulse is slow and full; the respirations are at first slow, regular, and stertorous, later on becoming of the Cheyne- Stokes type. 7. See French's Practice of Medicine (1907), pages 771 et seq.; or Osier's Practice of Medicine (1909), pages 508 et seq. 8. See French's Practice of Medicine (1907), pages 745 et seq.; or Osier's Practice of Medicine (1909), pages 470 et seq. PRACTICE OF SURGERY. 1. Backward dislocation of the hip is of two kinds: (1) On to the dorsum ilii ; (2) on to the sciatic notch. Dorsal dislocation: Head of femur lies on the dorsum ilii, and can be felt in the buttock. The obturator internus is rup- tured in most cases. The short rotator muscles are lacer- ated. The trochanter lies well above Nelaton's line and approximated to the anterior superior iliac spine. The leg is shortened two to three inches. The iliotibial band is relaxed. The leg is flexed, adducted, and inverted. The femur crosses the lower third of the opposite thigh. The toe rests on the opposite instep. A hollow exists in Scarpa's triangle. Sciatic dislocation: Similar to the above, except in the following: — The obturator internus tendon is intact and lies over the neck of the femur, holding it down in the sciatic notch. Shortening amounts only to one inch or less. The axis of the femur crosses the opposite knee. The great toe rests on the dorsum of the opposite great toe. Treatment: In posterior luxation of the hip joint the patient should be placed on a mattress on the floor, and then be anesthetized. The leg is then to be flexed on the thigh, and the thigh flexed on the abdomen; adduction is to be increased so that the knee is beyond the middle line of the body; then abduct, freely circumduct outward, and finally extent the limb so that it is parallel with the other. Ligaments injured: Ligamentum teres and capsular ligament. 2. For the technique see any textbook on Operative Surgery. In amputation through the middle of the arm the following parts are divided: Skin; fascia; biceps, tri- ceps, and brachialis anticus muscles; brachial, superior profunda, and inferior profunda arteries; brachial, basilic, and cephalic veins ; median, ulnar, internal cutaneous, musculospiral, and musculocutaneous nerves; and hu- merus. 3. See Rose and Carless' Surgery (1902), page 966; or Da Costa's Surgery (1903) page 48. 568 MEDICAL RECORD. 4. See Rose and Carless' Surgery (1902), page 918; or Da Costa's Surgery (1903), page 797^ 5. Femoral hernia is always acquired, and has a sac. Its course is first vertical, then forward, then upward over Poupart's ligament. Its coverings, from without inward, are : Skin, superficial fascia, cribriform fascia, crural sheath, septum crurale, subserous tissue, and peritoneum. The neck of the hernia is situated at the femoral ring; to its outer side lies the femoral vein, and to its inner side is Gimbernat's ligament; in front of it is Poupart's ligament, and behind it are the pubis, the pectineus, and the pubic portion of the fascia lata. In the immediate neighborhood of the femoral ring are: Anteriorly, the communicating branch between the deep epigastric and the obturator ar- teries ; externally, the femoral vein and deep epigastric vessels; superiorly, the spermatic cord or round liga- ment) and the deep epigastric vessels. For details of operation see Rose and Carless' Surgery (1903), page 991; or Da Costa's Surgery (1903), page 841. 6. Etiology: It is caused by infection, the bacteria gaining entrance either through a wound or by extension from neighboring tissues, or they may be brought by the blood. Pathological Changes: "The area of the medulla affected becomes hyperemic ; exudation occurs in the cancellous spaces, Haversian canals, and under the periosteum. Pus soon forms in these three situations. If the disease begins in the superficial part of the bone, the pus may only be subperiosteal, the deeper part of the bone escaping, though large areas of the superficial portion may die from the combined action of (1) stripping up of the periosteum by the pus, (2) strangulation of the vessels in the bone by the pressure of the exudation, and (3) the toxic action of the bacterial products. . . . When the disease begins in the deeper layers of the bone, the pus may reach the periosteum, or extend along the medullary cavity, so that the veins become filled with septic thrombus, which may be disintegrated and carried off as septic emboli (pyemia). There is profound toxemia, and necrosis of the whole diaphysis may occur. ... If the infection is mild, a chronic abscess may be formed in the cancellous tissue. The usual course of an acute case, if a patient survives, is that there is some necrosis of the shaft of the bone. The abscess bursts externally, and there are numerous openings in the skin leading through openings (cloacae) in the periosteum and involucrum down to the sequestrum. The sequestrum becomes loose in six weeks to six months. Symptoms: Sudden onset; pain, tenderness, fever, chills, swelling of soft parts; sometimes the joint can be moved gently without pain ; scepticemia or pyemia, may be pres- ent." It is to be diagnosed from (1) Rheumatism, in which 569 MEDICAL RECORD. more than one joint is affected and the tenderness is in the joint, and not near it. (2) Tubular arthritis, in^ which the onset is slow and the trouble starts in the epiphysis rather than in the diaphysis. (3) Cellulitis, in which the bone and periosteum are not affected, and in which there is always a wound. Treatment: Immediate incision through the periosteum ; the surface of the bone must be opened, pus evacuated, and drainage instituted; irrigation with hot bichloride solution and packing with gauze. The medulla of the bone must be freely exposed, and any sup- purating material removed. Constitutional treatment and rest are indicated. 7. The triangles of the neck are: (1) Anterior (contain- ing the inferior carotid, superior carotid, and submaxillary triangles) ; (2) Posterior (containing the occipital and subclavian triangles). For the relations of the common carotid see Cunningham's Anatomy (1905), page 802; or Gray's Anatomy (1908), page 600; for the ligations, see Rose and Carless' Surgery (1902), page 283; or Da Costa's Surgery (1903), page 348. 8. Pyelitis is due to: (1) calculi; (2) tuberculous disease; (3) extension of sepsis from the bladder and urethra; (4) sometimes movable kidney; (5) the ingestion of cantharides or turpentine; (6) a pyemic embolus. The lining membrane is red and swollen, and exudes muco-pus or pus. A certain amount of hydronephrosis occurs from the blockage produced by the swelling. When pyogenic organisms are present, the kidney sub- stance may be invaded (pyelonephritis). Perinephric sup- puration may follow from extension. The Symptoms are pain and tenderness over the kidney, frequency of micturition, and pus in acid urine, unless there is cystitis as well, when the urine is alkaline. The pyuria is intermittent when the ureter is occasionally blocked. Treatment: The cause is removed if possible. When pyelitis is due to extension from the bladder, the latter must be attended to. EYE AND EAR i. Mastoid abscess. Etiology: Infection from naso- pharynx or ear, purulent otitis, exanthemata, grippe, in- flammation of middle ear. Symptoms: Tenderness, pain, swelling and redness over the mastoid; bulging of the superior and posterior parts of the auditory canal ; tem- perature variable, from normal up to about 104 F. Treat- ment: Hot water, or cold water, or ice; leeches; purga- tives; light diet; acetanilid; incision, or mastoid operation. Operation: A semicircular incision of the soft parts is carried from a point about one-half inch above the attach- ment of the auricle, backward and downward, keeping 570 MEDICAL RECORD. parallel to the auricular attachment and terminating at the tip of the mastoid. The periosteum is now elevated or dissected from the bone and the osseous structure thoroughly exposed by means of retractors, which are held by an assistant, the auricle being pulled forward so as to lie upon the side of the head. The hemorrhage is controlled by the use of hot sponges and artery forceps. The surface of the mastoid is thoroughly examined for areas of necrosis or the existence of a fistulous opening, especially if a fluctuating swelling obtains previous to the operation. If these exist, the openings are enlarged by means of a gouge or a chisel and mallet, and followed inward to their origin. Should the surface present a healthy appearance, the primary opening of the mastoid is made into the antrum by means of the chisel, the point of entrance being effected just below the line of the superior wall of the meatus and about one-quarter of an inch backward from the posterior wall or anterior edge of the mastoid bone. When the antrum has been exposed, the cortex of the mastoid is chiselled away from this point downward toward the tip until a sufficient amount has been removed to expose all parts of the mastoid process. The cells are now all broken down, and every vestige of a necrotic or granulating area is completely eradicated. A free communication of the antrum with the tympanum should be established, which may be proved by syringing an antiseptic solution into the antrum, when it will escape from the external auditory meatus through a previous perforation of the drum head. The cavity of the mastoid is packed with sterile gauze, and the flaps of overlying tissue allowed to regain their former position, when a gap remains between their edges, through which the dressings may be changed (From Ailing and Griffin's Epitome on Eye and Ear). 2. In gonorrheal conjunctivitis: The conjunctiva and the lids are red and swollen ; the secretion contains pus, in which the gonococcus may be found ; the eye is tender and painful ; the cornea may ulcerate ; there is generally a history of gonorrheal infection. In blepharitis: The margins of the lids are swollen and reddened; the lashes fall out, and may or may not grow again ; the lids are glued together by yellowish crusts ; under these crusts are ulcers which bleed readily; itching, soreness, epiphora, and sensitiveness to light are noticed; there may be eczema of the eyelids. 3. Myringitis. Etiology: Trauma; extension of in- flammation from middle ear or nasopharynx ; exposure. Symptoms and Diagnosis: Pain, fulness; tinnitus; slight disturbance of hearing; if abscess forms the pain is great. Treatment: Irrigate auditory canal with a warm 571 MEDICAL RECORD. alkaline antiseptic solution, or with a solution of corrosive sublimate 1:5,000, and insert a pledget of cotton in the meatus; vesicles should be opened. 4. In corneal ulcer the patient's general condition must be kept up with proper food, hygiene, fresh air, tonics, and attention to bowels, etc. Atropine, antiseptic applica- tions, bandages, hot compresses, paracentesis of the cornea, or Saemisch's operation (division of the ulcer) are in- dicated. 5. The membrana tympani separates the external audi- tory meatus from the tympanic cavity. It is a thin, semi- transparent, oval membrane, broader above than below, concave outwards, and lying obliquely downwards and inwards. The most depressed part of the cavity is called the umbo. Its outer surface is continuous with that of the meatus; its inner covering is reflected from the lining of the tympanum; between the two is a fibrous membrane. There can be seen a ridge formed by the handle of the malleus, and also a bright triangular reflection of light at the anterior and lower part, running from the umbo towards the periphery. This is called the "pyramid of light." It is lustrous, and of a pearly color. CHEMISTRY. 1. Chemistry is that branch of science which treats of the composition of substances, their changes in composi- tion, and the laws governing such changes. 2. A deliquescent substance is one that absorbs sufficient moisture from the air to form a solution ; example, calcium chloride. An efflorescent substance loses its water of crystallization on exposure to the air; example, sodium carbonate. An effervescent substance, when placed in a liquid, causes sudden liberation of a gas; example, seid- litz powder. A fluorescent substance possesses the quality of lowering the refrangibility of light rays so as to con- vert the invisible ultraviolet rays into visible violet rays; example, quinine. 3. Sugar: Render the urine strongly alkaline by addi- tion of Na 2 C0 3 . Divide about 6 c.c. of the alkaline liquid in two test tubes. To one test tube add a very minute quantity of powdered subnitrate of bismuth, to the other as much powdered litharge. Boil the contents of both tubes. The presence of glucose is indicated by a darker black color of the bismuth powder, the litharge retaining its natural color. Albumin: The urine must be perfectly clear. If not so, it is to be filtered, and, if this does not render it transparent, it is to be treated with a few drops of mag- nesia mixture, and again filtered. The reaction is then observed. If it be acid, the urine is simply heated to 572 MEDICAL RECORD. near the boiling point. If the urine be neutral or alkaline, it is rendered faintly acid by the addition of dilute acetic acid, and heated. If albumin be present, a coagulum is formed, varying in quantity from a faint cloudiness to entire solidification, according to the quantity of albumin present. The coagulum is not redissolved upon the addi- tion of HX0 3 . Pus in the urine : Acidify the urine with acetic acid, then filter it, and treat the filter with a few drops of freshly prepared tincture of guaiacum ; a deep blue color denotes the presence of pus. Blood: To the urine add a solution of potassium hydroxide to distinct alkaline reaction ; heat nearly to boiling (do not boil). A red precipitate is produced. Urea: "The specific gravity of the urine is carefully de- termined, as well as that of the liquor sodae chlorinatse. One volume of the urine is than mixed with exactly seven volumes of the liquor sodse chlorinatse, and, after the first violence of the reaction has subsided, the mixture is shaken from time to time during an hour, when the decomposi- tion is complete ; the specific gravity of the mixture is then determined. As the reaction begins instantaneously when the urine and reagent are mixed, the specific gravity of the mixture must be calculated by adding together once the specific gravity of the urine and seven times the specific gravity of the liquor sodae chlorinatae, and divid- ing the sum by eight. From the quotient so obtained the specific gravity of the mixture after decomposition is subtracted; every degree of loss in specific gravity indi- cates 0.7791 gram of urea in 10c c.c. of urine. The specific gravity determinations must all be made at the same temperature ; and that of the mixture only when the evolution of gas has ceased entirely." (Witthaus' Manual of Chemistry.) 4. The empirical formula shows only the composition, that is, the number and kinds of atoms that are present in a molecule. The graphic formula shows both the com- position and the constitution, that is, the relation that the atoms bear to each other within the molecule. The empirical formula for acetic acid is GH 4 2 ; the graphic formula is CH, .COOH. 5. An equation is an expression, by means of symbols, numbers and signs, of a chemical action. HgSO* + Hg + 2XaCl = Na 2 S0 4 + Hg 2 Cl*. 6. The equivalent weight is the weight of an atom or radicle which can replace or combine with one part by weight of hydrogen or chlorine. It is the atomic weight of the element divided by its valence. 7. Molecular weight is the weight of a molecule of a substance as compared with the weight of an atom of 573 MEDICAL RECORD. hydrogen. It may also be said to be the sum of the weights of the atoms composing the molecule. Thus, the molecular weight of sulphuric acid, H2SO4 is (2 -\- 32 -\- 64), that is 98; or 98 times the weight of an atom o£ hydrogen. 8. Specific heat is the amount of heat required to raise the temperature of a substance a given number of degrees* The unit of specific heat is the Calorie, which is the amount of heat required to raise the temperature of one gram of water from 4 to 5 C. MEDICAL JURISPRUDENCE. i. The requisites of a hypothetical question, are: (1) It should embrace substantially all the evidence in the case relating to the subject. (2) It need not embrace all the evidence on the subject. (3) Each side may submit a different hypothetical question, based on the hypothesis of the facts which it considers proved. (4) It should be sufficiently explicit to warrant the formation of an opinion. (5) It should contain no irrelevant matter. An expert witness may give his opinion on facts or supposed facts as noted by himself or asserted by others. Theoretically, this can only be done by one perfectly familiar with the subject in question; but practically any (or almost any) physician with a license to practise is accepted as an expert witness. A non-expert witness testifies only the facts which he has seen, or heard, or with which he has become acquainted by personal observa- tion. 2. The constituent elements of blood, are : Red corpuscles, white corpuscles, platelets, and serum. In mammals as a rule, the red corpuscles are circular and nonnucleated ; in ovipar- ous vertebrates, as a rule, the red corpuscles are oval and nucleated. The blood of different mammals is differen- tiated by the measurement of the red corpuscle. To identify blood stains: (1) Some of the material from the suspected stain is thoroughly mixed with a few drops of a saturated solution cf sodium chloride, and then allowed to evaporate to dryness on a slide covered with a cover-glass. Now add a drop of glacial acetic acid to the slide, and allow it to enter under the cover slip; then apply gentle warmth. If the suspected stain is blood, crystals of hemin will form later, and can be seen under the microscope; this will not be the case with iron rust. (2) The demonstration of the corpuscles by the aid of the microscope; (3) spectroscopic appearance of two dark absorption bauds in the green rays, and at the junction of the green and yellow rays; (4) chemical tests, and as the action of guaiacum and ozonic ether, nitric acid, or caustic potash, S^ 574 MEDICAL RECORD. 3. A wound (medicolegal) is an injury or lesion caused by mechanical or chemical means. Incised wounds are made by sharp-cutting instruments; the hemorrhage is free, the wound gaps, there is no bruising of the margins. Punctured wounds are deep wounds with a small orifice ; they are made by narrow instruments. Lacerated and contused wounds are made by blunt instru- ments and by crushing; the soft parts are torn, the edges are bruised and ragged, the deep parts are infiltrated with blood; there is little free bleeding. Gunshot wounds. A wound inflicted during life is generally characterized by hemorrhage, coagulation of the blood, eversion of the edges, and retraction of its sides. It may also be inferred that the wound was inflicted during life if any of the following are noticed : The presence of inflammation, swelling, pus, or gangrene on the edges of the wound, or if there is any sign of beginning cicatrization. The shape and size of the wound do not always correspond with that of the instrument making it, because: (1) The edges of the wound may retract; (2) variation may occur on account of the tension or relaxation of the skin at the time the wound was inflicted; (3) the weapon may be withdrawn at a different angle from that at which it was introduced; (4) other factors are the size, weight, sharpness, or force applied to the weapon. 4. For the details of post-mortem examinations, see any textbook on Medical Jurisprudence for Pathology). Lung? in which respiration has taken place float ; those in which it has not taken place sink. Further, the lungs before respiration are situated at the back of the thorax and do not fill the cavity: whereas, after respiration, they fill the whole thorax, (a) Artificial insufflation is a difficult operation, and is not likely to be attempted by the mother, or anyone else. If done, the lungs would be bloodless, and there would be air in stomach and intestines. Prac- tically, it need not be considered, (b) In cases of putre- faction, the air can be expelled by pressure, and none is found in the air cells ; further, putrefaction of the lungs occurs late, and if found, and the lungs sink, the child was born dead, (c) If the flotation has been caused by freez- ing, the lungs would sink after being thawed out. OBSTETRICS. 1. The conjugate diameter of the inlet of the pelvis is a line drawn down the middle of the sacral promontory to the top of the symphysis pubis. It is about four inches in length. The transverse diameter of the inlet of the pelvis is a line drawn risrht across the pelvis from one lateral margin of the brim to the other. It is about five inches in length. The conjugate diameter of the outlet of 575 MEDICAL RECORD. the pelvis is a line drawn from the tip of the coccyx to the lower surface of the symphysis pubis. It is about five inches in length. The transverse diameter of the outlet of the pelvis is a line extending across the pelvis from one tuberosity of the ischium to the other. It is about four inches in length. 2. The cause of rupture of the uterus is : Strong uter- ine contraction in combination with some obstacle to the birth of the fetus. It is apt to occur in cases of con- tracted or deformed pelves, transverse presentation, ob- struction from tumors, unduly large fetal head. 3. Expectant plan: Place the patient in bed, and if the bleeding is profuse, insert a tampon of iodoform gauze (one yard) well up against the cervix. If this fails to control the hemorrhage, reinforce it by another yard or two of gauze and a perineal pad and binder. Small doses (3j^) of the fluid extract of ergot should now be given every two or three hours. At the end of from eight to twelve hours remove the tampon, when the ovum may be found extruded from the cervix; if not, a vaginal douche of mercuric chloride (1:4000) must be given, and another tampon introduced. If, upon the removal of this second tampon at the end of ten or twelve hours, the ovum is not discharged, then more vigorous methods to secure its ex- pulsion must be adopted. Active plan: The physician's hands and instruments are sterilized; the patient is ether- ized and placed on an appropriate table; the genitalia are thoroughly cleansed and a vaginal douche of mercuric chloride (1:4000) is given; the anterior lip of the cervix is brought down to the vulvar orifice; the cervix is dilated if necessary; the placental forceps is introduced into the uterus, and as much as possible of the ovum is removed; the uterus is thoroughly curetted, and an intrauterine douche of sterile water is given. A light tampon of iodo- form gauze is placed in the vagina; the patient is then re- turned to bed. A strip of the gauze may be placed in the uterus in cases of sharp retroflexion, to secure free drain- age, and occasionally an intrauterine tampon will be neces- sary when the uterus refuses to contract and hemorrhage persists after the use of the curette." (Gould & Pyle's Pocket Cyclopedia.) 4. Grasp the uterus at once, through the abdominal wall, and massage it firmly. Anything in the uterus should at once be cleaned out. Pass one hand into the uterus, and with the other on the outside make firm pressure. A hypodermic of ergotin, or ergot can be given by an assis- tant. An intrauterine douche of hot sterilized water (about 115 F) may be given. Sometimes a very thorough packing and plugging of gauze of uterus and vagina may be necessary. Whatever is done must be done promptly; 576 MEDICAL RECORD. and everything likely to be needed for this emergency should be prepared beforehand in every labor. 5. Causes of Transverse Presentation: Prematurity^ of the labor; placenta prsevia ; narrowness of pelvic brim; great lateral obliquity of the uterus; multiple pregnancies; undue mobility of the child from excess of liquor amnii; accidental pressure externally from blows, falls, dress, etc.; repeated occurrence of cross-births in the same woman is probably due to a narrow pelvic brim. Treatment: Early correction of the presentation, converting it into a head, breech, or foot, by version (external, internal, or bipolar). In cases of arrested spontaneous evolution, with impaction, version is out of the question. The child is usually dead from compression ; the method of delivery is embryotomy, usually decapitation. — (From King's Obstetrics). 6. Puerperal eclampsia is an acute morbid condition, oc- curring during pregnancy, labor, or the puerperal state, and is characterized by tonic and clonic convulsions, which affect first the voluntary and then the involuntary muscles; there is total loss of consciousness, which tends either to coma or to sleep, and the condition may terminate in re- covery or death. The causes may be : Uremia, albuminuria, imperfect elimination of carbon dioxide by the lungs, medicinal poisons, septic infection ; predisposing causes are renal disease and imperfect elimination by the skin, bowels, and kidneys. Preventive treatment: (1) The amount of nitrogenous food should be diminished to a minimum ; (2) the production and absorption of poisonous materials in the intestines and body tissues should be limited and their elimination should be aided by improving the action of the bowels, the kidneys, the liver, the skin, and the lungs; (3) the source of the fetal metabolic products and the periph- eral irritation in the uterus should, if necessary, be re- moved by evacuating that organ. Curative treatment: (1) Controlling the convulsions (bv chloroform, veratrum, or chloral) ; (2) elimination of the poison or poisons which are presumed to cause the convulsions; (3) emptying the uterus under deep anesthesia, by some method that is rapid and that will cause as little injury to the woman as possible. 7. Indications for the use of forceps are: (1) Forces at fault: Inertia uteri in the presence of conditions likely to jeopardize the interests of mother or child, (a) Impending exhaustion; (b) arrest of head, from feeble pains. (2) Passages at fault: Moderate narrowing, s l A to z z A inches, true conjugate; moderate obstruction in the soft parts. (3) Passenger at fault: A. Dystocia due to (a) occipito- posterior, (b) mentoanterior face, (c) breech arrested in cavity. B. Evidence of fetal exhaustion (pulse above 160 or below 100 per minute). (4) Accidental complications: Hemorrhage; prolapse funis; eclampsia. All acute or 577 MEDICAL RECORD. chronic diseases or complications in which immediate de- livery is required in the interest of mother or child, or both. Conditions necessary for the use of forceps are: (i) The rectum and bladder must be empty; (2) the os uteri must be fully dilated; (3) the membranes must be ruptured ; (4) the pelvis must be of sufficient size. 8. In the nulliparous adult the uterus is about three inches long, about two inches wide at the upper part, and about one inch thick. The uterus lies between the rectum behind and the bladder in front ; it is below the abdominal cavity and above the vagina. Its position is one of slight anteflexion, with its long axis at right angles to the long axis of the vagina. The anterior surface of its body rests on the bladder, and the cervix points backward toward the coccyx. The uterus is not fixed, but moves freely within certain limits. It is held in place by ligaments — broad liga- ments, round ligaments, vesicouterine, and rectouterine. During pregnancy the uterus increases in size (from 3 to 12 inches in length; from iy 2 to 9 inches in breadth), in weight (from about one ounce to two pounds, not including its contents). The cavity is enlarged over 500 times. All the tissues (muscles, ligaments, arteries, veins, lymphatics, and nerves become tremendously hypertrophied. The uterus also changes its position ; at first it drops, later it gradually rises, till just before labor (when it again drops). DISEASES OF CHILDREN. 1. Night cries; lameness in the morning; a slight limp; tendency to become tired on slight exertion; wasting; spasm; pain; swelling; and deformity (either real or ap- parent) ; growing pains, sacroiliac disease, congenital dis- location of the hip, spinal caries and psoas abscess, infantile paralysis, lordosis, rickets, and rheumatism. 2. Etiology: Tuberculosis (traumatism and cold may be exciting causes). Pathology: It may begin in the synovial membrane, or acetabulum, or femur; if it begins in the bone it spreads to the synovial membrane and causes gen- eral infection of the joint. First of all the bacilli enter, multiply, and by their products cause irritation and new growth; as this advances embryonic connective tissue is formed, and the joint is filled with an effusion; later on caseation occurs, the joint is destroyed, and there may also be destruction of the surrounding tissues. 3. (1) Stage of incubation: Lasts about nine to twelve days, during which the child loses weight, but is not other- wise sick. (2) Stage of invasion lasts about four days, the child has catarrh, coryza, fever, sneezing, laryngitis; buccal spots appear about the first or second day, head- ache, anorexia, furred tongue, fever and diarrhea or vomit- ing may be present. The fever rises till the eruption ap- 578 MEDICAL RECORD. pears; the pulse is rapid, 120 to 150. (3) Stage of eruption: Eruption generally appears on fourth day (for details see above, Practice, No. 2) ; the fever and catarrh continue till the rash is fully developed. (4) Stage of decline: The eruption fades rapidly, is followed by desquamation, the other symptoms subside, but the bronchial catarrh is the last to disappear. 4. Symptoms: Sudden onset, severe localized pain, vom- iting, tenesmus, and passage of bloody mucus. There is a sausage-like tumor in the abdomen ; sometimes it can be felt in the rectum. Fecal impaction or appendicitis may simulate it, but in the former the swelling is less tender and is on the left side; in the latter there is fever, and the tumor is on the right side. Treatment: Laparotomy and reduction of the bowel as soon as possible. Gentle manipu- lations, enemata, and opium have been suggested, but these should be adopted only when surgical relief is not available. 5. Atelectasis Pulmonum is collapse of the lung. Symptoms: The child becomes livid or pale, also restless; he breathes quicker, and his temperature becomes subnor- mal ; pinched features, cold sweats, and cessation of the cough are all noticed. There are bronchial breathing, ab- sent or diminished vocal resonance, dullness on percussion at base and posterior border of lungs. Treatment: The child must be put at once in a hot mustard bath; then wrapped up in cotton wool, vomiting must be produced by an emetic; atropine sulphate (gr. 1/300-gr. 1/200) may be given hypodermically as a respiratory stimulant. 6. To peptonize coiifs milk: Put into a bottle one pint of fresh cow's milk and 4 ounces of water; add a powder containing 5 grains of pancreatic extract and 15 grains of bicarbonate of sodium ; shake the mixture. The mixture should be kept at a temperature of about no° F., by plac- ing the bottle in hot water ; it should be occasionally shaken. For partial peptonization, this is continued for 6 to 20 minutes ; for complete peptonization, two hours. 7. The principal clinical changes that occur in the skele- ton in rickets are : Enlargement of the epiphyses of the long bones, curvatures are increased, flat bones have promi- nences or thickenings, green stick fractures are common, the head is large and square, the ribs are beaded, the fontanelles are open, dentition is delayed and irregular, the wrists and ankles are thickened. 8. Hydrocephalus, Syphilis, and Mollities ossium. materia medic a and therapeutics. (1) I£. Tincturae aconiti, 3j. Liquoris ammonii acetatis, Jv. Spiritus setheris nitrosi, 3J. M. Siena : One tablespoonful every three hours in half a tumblerful of lemonade or effervescent water. 579 MEDICAL RECORD. (2) 5. Ammonii chloridi, gr. xxx. Tincturse opii camphoratse.^ Syrupi ipecacuanhas, aa 5iij. Syrupi pruni virginianse, 3J- Syrupi tolutani, q.s. ad Jiv. Misce. Signa : One teaspoonf ul every three hours. fy Morphinse sulphatis, gr. j. Ammonii chloridi, 3j. Spiritus chloroformi, 3j. Syrupi pruni virginianse, 3J. Mist, glycyrrhizae comp., ad 3 vn J. Misce. Signa: One tablespoonful every three hours. 2. Carbolic acid. Origin: From coal tar oil, by frac- tional distillation; or it can be made synthetically. Dose: One grain. Physiological action: "Irritant; caustic; anti- septic; disinfectant; deodorant; Darasiticidal ; antizymotic; antipyretic; in solutions of moderate strength, locally an- esthetic. The heart and respiration are at first stimulated and afterward depressed. Smokiness of the urine is a characteristic feature. ,, Treatment in case of poisoning: Sodium sulphate or magnesium sulphate, warm muci- laginous drinks, cardiac and respiratory stimulants by hy- podermic, warmth to the body, emetics, are all indicated. 3. The following is given by Einhorn: All substances that are liable to excite intensely the glands of the stomach must be excluded. Therefore all kinds of acids must be forbidden. The food should consist of material rich in albumin, while the quantity of starchy substances should be diminished. Thus all kinds of meat (even game), fish, oysters, eggs, milk should be taken in large quantities. Bread and butter are permitted. Potatoes, spinach, aspara- gus, green peas, farina, and rice should be taken only in small amounts. Whiskey and wines should, as a rule, be avoided. Cacao, weak tea, weak coffee, and beer can be given in moderate quantities. 4. Apomorphine hydrochloride. Dose: As an emetic, gr. 1/10 subcutaneously ; as an expectorant, gr. 1/30. Physiological action: It acts on the vomiting center in the medulla, hence is emetic ; it increases pulse, blood pressure, and rate of respiration; it is also an expectorant. Its w- dications are chiefly those requiring a prompt emetic; also as an expectorant in bronchitis and lobular pneumonia. 5. Spiritus /etherjs nitrosi is prepared from sodium nitrite, sulphuric acid, monosodic carbonate, potassium carbonate, alcohol, and water. Dose: 30 minims. Thera- peutic uses: In feverishness, nausea, asthma, flatulence, as a mild diaphoretic, diuretic, carminative. Common name: Sweet spirit of nitre. 6. An agent which increases the action of the skin and promotes perspiration. (1) Alcohol, Jss to ii; (2) Pulvis 580 MEDICAL RECORD. ipecacuaphae et opii, gr. x to xx; (3) Spiritus aetheris nitrosi, TTRxxx ; (4) Turkish bath. 7. (a) Cardiac tonics stimulate the cardiac muscle, and thus slow and strengthen its contractions. Examples : Digitalis and strophantus, (b) Cardiac stimulants in- crease the force and frequency of the heart beat when the heart is depressed. Examples : Alcohol and ether. 8. Cathartics increase or hasten the intestinal evacua- tion. They act by : Increasing peristalsis, stimulating in- testinal secretion, causing exosmosis of serum. Contra- indicated in inflammation of stomach, intestines, or peri- toneum, pregnancy, threatened intestinal hemorrhage. STATE MEDICAL BOARD EXAMINATION QUES- TIONS. Pennsylvania State Board of Medical Examiners. ANATOMY. 1. Describe the relations of the gall-bladder with its sur- rounding organs. 2. Describe the clavicle and its articulations. 3. Describe the heart, its cavities, and the vessels lead- ing into and from it. 4. Describe the hip joint and name its ligaments. 5. Describe the pancreas and name the important struc- ture that passes through its head. 6. Describe the position of the palmar arterial arches. 7. Describe the female mammary gland, with special reference to its lymphatics, and its relations with the sur- rounding structures. 8. What vessels furnish the nutritional, and what the functional, supply of blood to the lungs? 9. Name the external and internal rotators of the thigh. 10. Where are the motor centers of the cerebrum lo- cated, and how is their location delineated on the surface of the scalp? PHYSIOLOGY. 1. Explain the endogenous (internal) and exogenous (external) sources of the purin bases and the production of uric acid. 2. Name and describe the causes producing the respec- tive heart sounds. 3. Discuss the factors concerned in the venous circu- lation. 4. Describe the principal functions of the digestive juices. 5. Briefly describe visual accommodation, and mention the function of each involved factor. 581 MEDICAL RECORD. MATERIA MEDICA. I. Discuss the official iodine preparations with regard to their respective important medicinal properties, doses, and methods of employment. Q) Name the drugs that produce local anesthesia and describe the methods of using them. 3. Give the official names and the doses of the prepara- y^Xxons of mercury which are prescribed for internal admin- ^ istration. 4. Name the drugs that are pharmaceutical^ incompat- ible with the following: (a) iron salts, (b) vegetable alka- loids, (c) gum resins. 5. Correctly write the following prescription without abbreviation (using official titles and either Metric system or U. S. measure and Troy weight) : Take of : — Oil of Turpentine 120 minims Powdered Gum Arabic 3 drams Chloroform 16 minims Syrup of Tolu 2 fluidounces Peppermint Water a sufficient quantity to make 4 fluidounces Directions — One fluidram sufficiently diluted with water every three hours. CHEMISTRY. 1. Name and discuss the significance of five morbid products of the urine, and detail the tests for any two. 2. Give the chemical composition of two forms of urinary calculi and describe chemical tests for each form. 3. Name common and convenient antidotes for poison- ing by the mineral acids, and tell what course should be pursued when the acid to be counteracted is unknown. 4. Describe two chemical tests to be used in water sup- posed to be contaminated with sewage. 5. a State what diagnostic reaction takes place when dia- betic urine is added to a heated alkaline solution of potas- siocupric tartrate. PATHOLOGY. 1. Define infarcts, and state where they most frequently occur. 2. Explain the production of the respective cardiac val- vular murmurs, their conduction, and where most distinctly heard. 3. Describe the changes that occur in the crystalline lens in cataract. 4. Define and explain the causes of dry and senile gan- grene. 5. Discuss the direct and indirect effects of the gono- 582 MEDICAL RECORD. coccus upon the human body, and outline the technic for staining and recognizing its presence in the secretions. DIAGNOSIS. i. Differentiate acute pharyngitis and diphtheria. 2. Differentiate renal colic, hepatic colic, and appendi- citis. 3. Differentiate tabes dorsalis and ataxic paraplegia. 4. Diagnosticate cerebrospinal meningitis. 5. Diagnosticate interstitial keratitis. PRACTICE OF MEDICINE AND THERAPEUTICS. 1. Describe the course of a typical case of scarlet fever. 2. What are the symptoms of diabetes mellitus? 3. What are the symptoms of abscess of the liver? 4. W r hat are the symptoms of tuberculous peritonitis? 5. What are the symptoms and signs present in pleurisy with purulent effusion (empyema) ? 6. Outline a treatment for a case of acute follicular ton- sillitis. 7. Outline a treatment for tapeworm. 8. What are the symptoms of poisoning by belladonna and how would you treat it? 9. How would you treat a case of cholera morbus. 10. What are the indications and contraindications in the use of arsenic? SURGERY. i 1. Describe the surgical and adjuvant treatment of sep- tic peritonitis. 2. _ Give the symptoms of pyosalpinx and describe an op- eration for the same. 3. Describe the manipulations for the reduction of a posterior luxation of the hip joint. 4. Give a classification of burns, and the treatment for one of the third degree. 5. Define and outline the treatment for a penetrating wound of the urinary bladder. 6. Describe the symptoms of pyothorax (emypema) and an operation for its relief. 7. What are the general principles governing the treat- ment of fractures at or near joints? 8. Give the symptoms and treatment of dislocation of the semilunar cartilages of the knee joint. Q. Give the causes, symptoms, and treatment of varico- cele. 10. Describe methods of control of severe epistaxis. OBSTETRICS. 1. What maternal conditions would warrant the destruc- tion of fetal life? 583 MEDICAL RECORD. 2. Differentiate normal pregnancy, tumors within the ab- dominal cavity, and ectopic gestation. 3. During the process of an apparently normal labor, what conditions may arise requiring either version or- de- livery by the forceps? 4. What may be the causes of uterine hemorrhages dur- ing pregnancy, and what would be your treatment? 5. For repeated spontaneous abortion, what is the course of treatment? 6. Should you find albumin and tube casts, or sugar, in the urine of a pregnant woman, what morbid conditions would be indicated, and what would be your treatment? 7. How would you manage a face presentation, with the chin in the hollow of the sacrum? 8. When the action of the uterus is insufficient, what measures and remedies may be used to bring about normal contractions ? 9. Name the conditions requiring immediate delivery, and describe the methods of procedure. 10. What are the causes of ophthalmia neonatorum, and what means should be employed to prevent it? How should it be treated? HYGIENE. 1. What measures should be enforced to prevent the spread of diseases throueh the schools? 2. What regime should be enforced in the sick-room of a tuberculous patient? 3. Why should we avoid using a general drinking and communion cup? 4. What methods are necessary in cities to reduce in- fant mortality resulting from digestive diseases? 5. Explain why the principles of "preventive medicine ,, can be more successfully and efficiently applied in the properly appointed home, with ample accommodations, than in a public or municipal institution? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Pennsylvania State Board of Medical Examiners. ANATOMY. 1. The gall bladder is in relation above with the liver; below, with the first part of the duodenum, the hepatic flexure of the colon, the beginning of the transverse colon, and the pylorus; the fundus approaches the anterior ab- dominal wall behind the ninth costal cartilage and near the outer border of the right rectus abdominis muscle. 584 MEDICAL RECORD 2. See Cunningham's ''Anatomy'' (1909), page 181; or Gray's "Anatomy" (1908), page 169. 3. See Cunningham's "Anatomy" (1909), page 783; or Gray's '"Anatomv" (1908), page 564. 4. The hip- joint is an enarthrodial joint, formed by the head of the femur and the acetabulum. The articular sur- faces are covered with cartilage. Near the center of the head of the femur is attached the ligamentum teres. The ligaments are: (1) The capsular, which embraces the mar- gin of the acetabulum above, and the neck of the femur below. (2) The ileo-femoral or Y ligament, which passes obliquely across the front of the joint, and is attached above to the anterior inferior spine of the ileum, and below to the anterior intertrochanteric line. -(3) The liga- mentum teres. (4) The cotyloid ligament, which deepens the acetabulum and bridges over the cotyloid notch, being- there called (5) the transverse ligament. The joint has a very extensive synovial membrane. It is capable of the following movements : Flexion, extension, abduction, ad- duction, circumduction, and rotation. 5. See Cunningham's "Anatomy'' (1909), page 1124; or Gray's "'Anatomy''' (1908), page 1355. 6. The position of the superficial palmar arch is repre- sented by a line going across the palm of the hand from a point where the web of the thumb joins the palm. The position of the deep palmar arch is represented by a line roughly parallel with the above, but one-half inch nearer to the wrist. 7. See Cunningham's '"Anatomy" (1009), pages 1207 and 323: or Gray's "Anatomy" (1908), page 1516. 8. The bronchial and pulmonary arteries respectively. 9. The external rotators of the thigh are: Obturator externus, Obturator interims, Gemellus superior, Gemellus inferior, Gluteus maximus, Gluteus medius and minimus (posterior fibers), Pyriformis, Quadratus femoris, Ad- ductor longus, Adductor magnus, Adductor brevis, Pec- tineus, Ilio-psoas, Sartorius. The internal rotators of the thigh are: Tensor vaginae femoris, Gluteus medius and minimus (anterior fibers). 10. The motor centers of the cerebrum are located in the ascending frontal and ascending parietal convolutions, and the cortex adjacent thereto: they lie on each side of the fissure of Rolando. The leg center occupies the upper third of this part on the cortex, the arm center the middle third, and the face center the lower third. On the median si- r face, the centers for the head, trunk, and lower extremities are situated in this same order from before backwards. To locate the fissure of Rolando on the scalp: Draw a straight line over the top of the scalp from the inion to 585 MEDICAL RECORD. the glabella; bisect this line, and half an inch posterior to the midpoint draw a line downward and forward at an angle of 67.5 for a distance of three and one-half inches. This line will represent the location of the fissure of Rolando. PHYSIOLOGY. 1. Uric acid belongs chemically to the group of sub- stances called "purins," uric acid being trioxypurin. The uric acid which is derived from the purin bodies con- tained in the food is called "exogenous" uric acid; while that which comes from the breaking down of the tissues of the body which contain amiuo purins and oxypurins or nucleins is called "endogenous" uric acid. 2. The causes producing the first sound of the heart are not definitely ascertained; the following are supposed to be causatory factors: (1) The vibration and closure of the auriculo-ventricular valves, (2) the muscular sound pro- duced by the contraction of the ventricles, and (3) the cardiac impulse against the chest wall. The second sound is caused by the vibration due to the closure of the semilunar valves. 3. The factors concerned in the venous circulation are: (1) The action of the heart, (2) aspiration of the thorax, (3) the contraction of the muscles, and (4) some slight action of the valves in the veins. 4- DIGESTIVE JUICES. Saliva Gastric juice Pancreatic juice. Intestinal juice. ACTIVE PRIN- CIPLE. Ptyalin. Pepsin. A curdling ferment. Trypsin. Amylopsin. Steapsin. A curdling ferment. Invertin. 5«T ACTION. Changes starches into dextrin and sugar. Changes proteids into proteoses and peptones in an acid medium. Curdles the casein of milk. Changes proteids into proteoses and peptones, and afterwards decom- poses them into leucin and tyrosin; in an al- kaline medium. Converts starches into maltose. Emulsifies and saponifies fats. Curdles the casein of milk. Converts maltose into glucose. MEDICAL RECORD. The bile is also a digestive juice, and its functions are as follows: (i) To assist in the emulsification and saponi- fication of fats; (2) to aid in the absorption of fats; (3) to stimulate the cells of the intestine to increased secretory activity, and so promote peristalsis; and at the same time tend to keep the feces moist; (4) to eliminate waste prod- ucts of metabolism, such as lecithin and cholesterin ; (5) it has a slight action in converting starch into sugar; (6) it neutralizes the acid chyme from the stomach, and thus inhibits peptic digestion; (7) it has a very feeble antiseptic action. 5. "Mechanism of Accommodation. — The lens is an elas- tic structure, and when released from the flattening in- fluence of its suspensory ligament tends to assume a spherical shape. During accommodation the ciliary muscle (especially the circular fibers) contracts, drawing forward the chorioid and relaxing the suspensory ligament; this diminishes the tension of the lens capsule and allows the inherent elasticity of the lens to increase its convexity. The change in curvature affects chiefly the anterior surface of the lens. This is Helmholtz's theory and the one usually accepted. Lately Tscherning has advanced a dif- ferent theory; he maintains that the ciliary muscle in- creases the tension of the suspensory ligament during contraction and that this causes peripheral flattening of the lens with bulging anteriorly at its center. The act of accommodation is accompanied by contraction of the pupil, and (in binocular vision) by convergence of the visual lines." — May's Diseases of the Eye. MATERIA MEDICA. i. Tinct re of iodine: Used as a local application, or for injection into cavities. It is an irritant, disinfectant, ab- sorbent, and parasiticide. Compound solution of iodine, dose tl^iij, well diluted; action as the tincture. Potassium iodide, dose gr. vij ; Sodium iodide , dose gr. vij ; Ammonium iodide, dose gr. iv ; Strontium iodide, dose gr. vij ; Zinc iodide, dose gr. j. The iodides are irritant, absorbent, and alterative ; in excess may produce iodism. Iodoform, gener- ally used as a dusting powder for syphilitic and other ulcers. 2. The drugs that produce local anesthesia are: (1) Ether, (2) Rhigolene, (3) Ethyl chloride, (4) Cocaine, (5) Eucaine, (6) Holocaine, (7) Stovain, (8) Schleich's solu- tion. Nos. 1, 2, and 3 are used as a spray; Nos. 4, 5, 6, and 7 are used hypodermically, or by being applied to a mucous surface ; Schleich's solution is used by infiltration. 3. The official names and doses of the preparations of mercury which are prescribed for internal administration are: (1) Hydrargyri choloridum corrosivum, gr. 1/20; 587 MEDICAL RECORD (2) hydraragyri iodidum rubrum, gr. 1/20; massa hy- drargyri, gr. iv ; (4) hydrargyri chloridum mite, gr. ij ; (5) hydrargyrum cum creta, gr. iv; (6) hydrargyri iodidum flavum, gr. 1/5; (7) hydrargyri subsulphas flavus, gr. 1/4 to 1/2. 4. The incompatibles of (a) the iron salts are: Vege- table astringents, alkalies, acids, phenol; (b) of the vege- table alkaloids: alkaline hydrates, tannic acid, picric acid, salicylates, bromides, iodides, chlorides, bromine, iodine; (c) of the gum resins: oxidizing agents, phenol, menthol. 5. Recipe : Olei terebinthinaa 3ij Pulveris acaciae 3iij Chlorof ormi fftjxvj Syrupi tolutani . , % . 3ij Aquae menthae piperitae quantum sufficiat ad %iv Misce. Signa: One teaspoonful in half a glass of water, every three hours. CHEMISTRY. 1. Five morbid products- in the urine: Albumin, glu- cose, acetone, pus, and excess of indican. Albumin is found in the urine: "(1) In fevers, as typhoid and pneumonia; (2) in valvular heart lesions, degeneration of the heart muscle, diseases of the coronary arteries, im- peded pulmonary circulation, in pregnancy by pressure upon the renal veins, in intestinal catarrh, and in Asiatic cholera; (3) in purpura, scurvy, leukemia, pernicious anemia, jaun- dice, diabetes, and syphilis ; (4) after taking Pb, Hg, I, P, As, Sb, chloroform, cantharides, oxalic, carbolic, salicylic or. the mineral acids, turpentine, and nitrates; (5) in large amounts in acute nephritis and chronic parenchymatous nephritis; in small amount in chronic interstitial nephritis and amyloid kidney." Glucose is found in urine as ''transitory glycosuria/' "(1) in certain hepatic derangements, congestion, cirrhosis, and amyloid degeneration ; (2) in many diseases of the central nervous system, with tumors or hemorrhages at the base of the brain, in meningitis, concussion, fracture of cer- vical vertebrae, railway injuries, in epileptic and apoplectic seizures, and also in certain diseases of the peripheral nervous system, as in sciatica and in tetanus; (3) in acute febrile diseases, pneumonia, typhoid, acute articular rheu- matism, scarlatina, etc., particularly during convalescence; (4) under the influence of many poisons, such as curare, chloral, carbon monoxide, morphine, arsenic, and the anes- thetics. As 'permanent glycosuria' (1) in lesions of the brain involving the floor of the fourth ventricle ; and (2) in diabetes mellitus/' 588 MEDICAL RECORD. Acetone is found in the urine "in febrile diseases when the febrile condition is prolonged, in certain mental dis- eases, such as general paresis, melancholia and epilepsy, after chloroform narcosis, in puerperal eclampsia, and in diabetes." Pus is found in the urine in suppuration of any part of the urinary tract, and in case of rupture of an abscess into that tract. Excess of indie an is found in the urine "in hypochlor- hydria ; in hyperchlorhydria of gastric ulcer ; in conditions in which there is diminished peristalsis of the small intes- tines, as in ileus and peritonitis, not in simple constipation; also in conditions in which putrefactive changes occur in the body elsewhere than in the intestine, as in empyema, putrid bronchitis, gangrene of the lungs, etc/' Test for Albumin. — The urine must be perfectly clear. If not so, it is to be filtered, and, if this does not render it transparent, it is to be treated with a few drops of mag- nesia mixture, and again filtered. The reaction is then observed. If it be acid, the urine is simply heated to near the boiling point. If the urine be neutral or alkaline, it is rendered faintly acid by the addition of dilute acetic acid, and heated. If albumin be present, a coagulum is formed, varying in quantity from a faint cloudiness to entire solidi- fication, according to the quantity of albumin present. The coagulum is not redissolved upon the addition of HN0 3 . Test for indican in the urine: The urine is mixed with one-fifth its volume of 20 per cent, solution of lead acetate and filtered. The filtrate is mixed with an equal volume of fuming hydrochloric acid containing 3:1000 of ferric chloride, a few drops of chloroform are added, and the mixture strongly shaken one to two minutes. With normal urine the chloroform remains colorless, or almost so; but if an excess of indoxyl compounds be present the chloro- form is colored blue, and the depth of the color is a rough indication of the degree of the excess. — From Witthaus' Essentials of Chemistry. 2. Two forms of urinary calculi: (1) Uric acid calculi, and (2) ammonium urate calculi. Chemical tests: Saw the calculus in two, take some of the sawdust and heat it on a platinum foil. If it is entirely volatile, take a fresh portion of the dust, moisten with nitric acid, evaporate to dryness at a low heat, add some ammonium hydroxide solution; a red color will be pro- duced. Treat a portion of the dust with solution of potassium hydroxide, but without heating; if an ammoniacal odor is observed, the calculus is ammonium urate; if no such odor is observed, the calculus is uric acid. 3. In cases of poisoning by the mineral acids magnesia in .water, or a strong solution of soap should be adminis- 580 MEDICAL RECORD. tered. The same course of treatment should be pursued even if the acid is not known. 4. (1) Wanklyn's ammonia process: "Half a liter of the water to be examined, made alkaline if necessary, is put into a large flask, connected with a Liebig's condenser by means of a bent glass tube passing through a perforated India rubber stopper. The flask is heated by a Bunsen's burner, and the first 50 c.c. of distillate are collected and Nesslerized, and the amount of ammonia they contain is recorded. This ammonia is part of the free ammonia con- tained in the water as such, and it is found by experience that the first 50 c.c. contain three-quarters of the free am- monia. Hence, adding one-third to the amount recorded in the first 50 c.c, we get the whole amount contained in the half liter of water under analysis, and, doubling this, the mgrs. of free ammonia per liter, i.e. parts per million. "Thus, if the first 50 c.c. strike a tint with Nessler, which is matched in the second glass by the addition of 1.2 c.c. standard ammonia solution, we must allow one-third of 1.2, that is, 0.4, making a theoretical total of 1.6 c.c. This corresponds to 0.016 mgr. of ammonia in the half liter taken for analysis, or 0.032 part per million. Meanwhile 150 c.c. more are distilled over, to exhaust the free am- monia, but, as already explained, it is unnecessary to Ness- lerize these. "There are then 300 c.c. left in the flask, and to this are now added 50 c.c. of the alkaline permanganate, and the distillation is resumed. The first, second, and third 50 c.c. are collected separately and Nesslerized. Should the third 50 c.c. be found to contain noteworthy quantities of am- monia, a fourth 50 c.c. are distilled over. "The ammonia coming over at this second stage is called albuminoid ammonia, being derived from the albuminoid and other nitrogenous organic matter in the water. The second 50 c.c. contain much less than the first, and the third less than the second. Adding together the amount of ammonia found in the three lots, we have the total for the half liter of water; and twice this will give the propor- tion in parts per million. Thus : 1st 50 = 2.5 c.c. standard ammonia solution. 2d 50=1.0 c.c. 3d 50 = 0.3 c.c. Total = 3.8 c.c. =0.038 mgr. ammonia per half liter. Albuminoid ammonia = 0.076 part per million." — (Whitlegge's Hygiene.) (2) Kjeldahl's process is based upon the conversion of the nitrogen of organic substances into sulphate of am- monia if charred by heating with strong sulphuric acid. The water is concentrated by distillation, and charred by 590 MEDICAL RECORD. strong sulphuric acid. The organic residue is then broken up with permanganate of potash in the presence of a caustic alkali. On further distillation the organic nitrogen is determined from the resulting ammonia by Nesslerizing. The organic nitrogen by Kjeldahl's process is about twice the nitrogen of the albuminoid ammonia, and in usable drinking water does not usually exceed 0.016 parts per 100,000. Any water, unless peaty, containing more than this may be regarded with suspicion.— (Notter and Firth.) 5. When diabetic urine is added to a heated alkaline solution of potassiocupric tartrate, a yellow or red precipi- tate is formed. PATHOLOGY. i. Infarcts are areas of tissue in which, owing to the plugging up of an end artery or terminal artery, nutrition is prevented. Infarcts most frequently occur in the kidneys, spleen, lungs, base of brain, retina, and heart. 2. See French's "Practice of Medicine" (1907), pages 574, etc.; or Osier's "Practice of Medicine" (1909), pages 793, etc. 3. "Cataract means opacity of the crystalline lens, and is due to changes in the structure and composition of the lens fibers. The capsule is often thickened, but otherwise not much altered. The changes seldom occur throughout the whole lens at once, but begin first in a certain region, e.g. the center {nucleus) or the superficial layers {cortex), while in some forms of partial cataract the change never spreads beyond the part first affected. With advancing age the lens, which is from birth firmest at the center, becomes harder, and acquires a very decided yellow color; its refractive power usually decreases, its surface reflects more light, and its substance becomes somewhat fluorescent. The result of all these changes is that at an advanced age the lens is more easily visible than in early life, the pupil becoming grayish instead of being quite black. This gray- ness of the pupil may easily be mistaken for cataract, but ophthalmoscopic examination shows that the lens is trans- parent, the fundus being seen without any appreciable haze. It has hitherto been supposed that the lens became smaller in old age, but the researches of Priestley Smith have lately shown that the lens continues to increase in all di- mensions so long as it remains transparent. As a rule, however, cataractous lenses are undersized. The consist- ence of a cataract depends chiefly on the patient's age. The wide physical differences between cataracts depend less on variations in the cause, position, or character of the opacity than on the degree of natural hardness which is proper to the lens at the time when the opacity sets in. 591 MEDICAL RECORD. Below about thirty-five all cataracts are 'soft.'" — (Nettle- ship's Diseases of the Eye.) 4. See Rose and Carless' "Surgery" (1907), pages 99 and 105. 5. The gonococcus, on being implanted on the mucous membrane of the urethra, may produce : Gonorrhea, ure- thritis, prostatitis, orchitis, epididymitis, vulvitis, vaginitis, endometritis, salpingitis, by direct extension ; conjunctivitis may result if the discharge is carried to the eye; by metastasis there may result : Gonorrheal arthritis, tenosy- novitis, involvement of the pleura, pericardium, endo- cardium, or myocardium ; also involvement of the lymphatic glands, e.g., bubo. To demonstrate the gonococcus: On a cover-glass make a smear with the discharge as thin as possible, and let it dry in the air ; cover it with a freshly-made solution of anilin-oil-gentian-violet for one or two minutes ; wash it in distilled water; leave it in Gram's solution for. two min- utes; wash it in 95 per cent, alcohol until decolorized; wash it in distilled water ; counterstain with a dilute car- bolfuchsin without heat, or with a saturated aqueous solu- tion of Bismarck brown; wash in distilled water, dry with filter paper, mount, and examine with an oil-immersion lens. The gonococci will appear as diplococci within the leuco- cytes, which have been decolorized by Gram's stain, and have taken the counterstain. DIAGNOSIS. 1. In acute pharyngitis there is little or no systemic dis- turbance ; the patient complains of pain and sore throat ; the pharynx is red and dry ; and there are no Klebs Loeffler bacilli present. In diphtheria there is severe constitutional disturbance; an exudate is present, which is removable only with diffi- culty, and recurs after removal, and contains the Klebs Loeffler bacilli. 2. In renal colic: The pain is in the region of the af- fected kidney, it radiates down the thigh ; there are intense rigors ; retraction of the testicle may be present ; also history of previous attacks or of calculi ; the urine may be scanty, suppressed, or bloody. In hepatic coli: The pain is in the region of the liver, it radiates to the right scapula and toward the umbilicus; chills and sweats are common ; also vomiting, and some- times symptoms of collapse and jaundice; calculi are found, if at all, in the feces. In appendicitis: The pain is at first diffuse, but later be- comes localized over the appendix in the right iliac fossa; nausea, vomiting, and constipation may be present; tender- ness over the appendix, and rigidity of the right rectus 592 MEDICAL RECORD. abdominis muscle are present ; there is generally moderate fever. 3. In tabes dorsalis: There are lightning pains, loss of knee jerk, the presence of the Argyll-Robertson pupil. In ataxia paraplegia: There are very rarely lightning pains, the knee jerk is exaggerated, ankle clonus is present, there is no Argyll-Robertson pupil. 4. See French's "Practice of Medicine" (1907), page 146; or Osier's "Practice of Medicine" (1909), page 163. 5. ''Interstitial keratitis commences as a slight cloudiness of the central portion of the cornea, with some roughening or irregularity of the epithelium. It extends from the cen- ter towards the margin, and is liable to be attended, in different cases and at different stages of its course, by variable degrees of ciliary and corneal congestion, and intolerance of light. If neglected, or if treated by irri- tants, it is liable to assume the characters of vascular kerati- tis, and also to extend to the iris, in such instances often doing irreparable mischief. It is most common during childhood, but its appearance may be delayed until adoles- cence, or even until adult age. It attacks both eyes, one commonly somewhat later than the other, and its course is often protracted over several months. V\ "hen severe, it leaves some residual cloudiness of the cornea, and, even when mild, it is doubtful whether the cornea ever entirely regains the transparency of health. Still, when a case is seen and judiciously treated early, the prognosis ma}* gener- ally be a favorable one." — (Quain's Dictionary of Medi- ci tie.) PRACTICE OF MEDICINE AND THERAPEUTICS. i. See French's "Practice of Medicine" (1907), page 317; or Osier's "Practice of Medicine" (1909), page 132. 2. See French's "Practice of Medicine" (1907), page 940; or Osier's "Practice of Medicine" (1909), page 414. 3. See French's /'Practice of Medicine" (1907), page 835; or Osier's "Practice of Medicine" (1909), page 564. 4. See French's "Practice of Medicine" (1907), page 357; or Osier's "Practice of Medicine" (1909), page 310. 5. See French's "Practice of Medicine" (1907), page 695; or Osier's "Practice of Medicine" (1909), page 649. 6. See French's "Practice of Medicine" (1907), page 719; or Osier's "Practice of Medicine" (1909), page 447. 7. See French's "Practice of Medicine" (1907), page 478; or Osier's "Practice of Medicine" (1909), page 30. 8. Symptoms of poisoning by belladonna: "In the first stage, that of delirium, there are dryness of the throat, thirst, difficulty of deglutition and spasms upon swallowing liquids, face at first pale, afterwards highly reddened, pulse extremely rapid, eyes prominent, brilliant, with widely- 593 MEDICAL RECORD. dilated pupils, complete paralysis of accommodation, dis- turbances of vision, attacks of giddiness and vertigo, with severe headache, followed by delirium, occasionally silent or muttering, but usually violent, noisy, and destructive, accompanied by the most fantastic delusions and hallucina- tions. Usually the urine is retained, and the body tempera- ture is above the normal. The delirium gradually sub- sides, and the second stage, that of coma, is established, with slow, stertorous respiration, and gradually failing pulse, until death occurs from respiratory or cardiac par- alysis, or sometimes in an attack of syncope during ap- parent amelioration." Treatment: Lavage of the stomach; morphine may be given cautiously during the period of violent excitement. Maintain respiration; strong coffee by the mouth or rec- tum is beneficial. Pilocarpine may be given, in not too large doses, to stimulate the secretion of saliva." — -From Witthaus' Essentials of Chemistrv. 9. See French's "Practice of Medicine" (1907), page 773. 10. Arsenic. Indications: To remove hairs, as a caustic; in gastric ulcer or cancer, irritative dyspepsia, pyrosis, diarrhea coming on immediately after eating, alcoholism, nausea, malaria, anemia, chlorosis, chorea, epilepsy, chronic rheumatism, chronic, scaly, and papular skin diseases. Con- traindications: Acute skin diseases and pulmonary tuber- culosis, with a tendency to hemoptysis. SURGERY. 1. See Rose and Carless' "Surgery" (1908), pages 975 and 969; or Da Costa's "Surgery" (1908), page 868. 2. Symptoms of pyosalpinx: Pain or discomfort, made worse by pressure, examination, or defecation; or colicky pains over the tube; dysmenorrhea; increased menstrual flow; tubes are found to be dilated and swollen. Treat- ment: Removal of the affected tube; or salpingo-oopho- rectomy. Operation of salpingo-oophorectomy: "(1) Perform a median abdominal section — control hemorrhage — and re- tract lips of abdominal wound. (2) Pass the first and second fingers into the wound, with the back of the hand to the abdomen ; follow down the under surface of the ab- dominal parietes to the symphysis, thence down on to the bladder and uterus, and thence out laterally over the superior cornu of the uterus, with the palm of the hand still downward, to and along the broad ligament, along the posterior superior aspect of which the Fallopian tube is found, and, just posterior to the tube, the ovary. These structures are drawn toward the median line into an ac- cessible position in the abdominal wound. (3) The ovarian artery and veins are first tied, with silk, the ligature being carried, upon a laterally curved aneurysm needle, through 594 MEDICAL RECORD. the clear space of the broad ligament and tied over the top of the infundibulopelvic ligament, outside of the fimbriated end of the Fallopian tube, and close to the brim of the pelvis. (4) The uteroovarian ligament, lying be- hind the Fallopian tube, is ligated with chromic gut, rather nearer the uterus, carried upon a laterally curved aneurysm needle. (5) The inner end of the Fallopian tube and the upper free part of the broad ligament are ligated with silk near the horn of the uterus — which ligature also controls the branches from the uterine artery. (6) The structures are now removed by cutting through the broad ligament well within the outer ligature of the ovarian vessels — and cutting through the Fallopian tube and ovarian ligament well to the outer side of their ligatures — and carrying the incision through the broad ligament well below the hilum of the ovary. Any doubtful ligature is strengthened, and any bleeding point is surrounded by an additional gut ligature. (7) The edges of the anterior and posterior layers of the broad ligament, left by the removal of the above structures, are sutured together with gut. The patient is lowered to the horizontal position and the intes- tines and omentum are replaced. (8) The abdomen is closed, as after median abdominal section." — (Bickham's Operative Surgery.) 3. In posterior luxation of the hip joint the patient should be placed on a mattress on the floor, and then be anes- thetized. The leg is then to be flexed on the thigh, and the thigh flexed on the abdomen ; adduction is to be in- creased so that the knee is beyond the middle line of the body; then abduct, freely circumduct outward, and finally extend the limb so that it is parallel with the other. 4. See Rose and Carless' "Surgery" (1908), pages 115 and 117; or Da Costa's "Surgery" (1908), pages 1052 and 1053. 5. See Rose and Carless' "Surgery" (1908), page u8g: or Da Costa's "Surgery" (1908), page 1128. 6. See Rose and Carless' "Surgery" (1908), page 926; or Da Costa's "Surgery" (1908), page 773. 7. See Rose and Carless' "Surgery" (1908), pages 475, 479, and 482; or Da Costa's "Surgery" (1908), page 497. 8. See Rose and Carless' "Surgery" (1908), page 635; or Da Costa's "Surgery" (1908), pages 607 and 635. 9. See Rose and Carless' "Surgery" (1908), page 1269;. or Da Costa's "Surgery" (1908), pages 1202 and 397. 10. See Rose and Carless' "Surgery" (1908), page 838; or Da Costa's "Surgery" (1908), page 390. OBSTETRICS. I. Certain pelvic deformities, placenta praevia, pernicious anemia, toxemia of pregnancy. 595 MEDICAL RECORD 2. See Williams' "Obstetrics" (1909), pages 190 and 647; or Hirst's "Obstetrics" (1909), pages 204 and 304. 3. Indications for the use of forceps are : Inertia uteri in the presence of conditions likely to jeopardize the in- terests of mother or child. Impending exhaustion; arrest of head, from feeble pains. Evidence of fetal exhaustion (pulse above 160 or below 100 per minute). Hemorrhage; prolapsus funis ; eclampsia. All acute or chronic diseases or complications in which immediate delivery is required in the interest of mother or child, or both, (b) Indications for version are : Prolapsed funis, sudden death of the mother, and in any case where speedy delivery is impera- tive. .4. Hemorrhage during pregnancy may be due to : Pla- centa praevia, premature separation of placenta, or apoplexy of decidua or placenta. Treatment: See Williams" "Ob- stetrics" (1909), pages 808 and 815; or Hirst's "Obstetrics" (1909), pages 577 and 585. 5. See Williams' "Obstetrics" (1909), page 618; or Hirst's "Obstetrics" (1909), page 279. 6. See Williams' "Obstetrics" (1909), pages 201, 520, and 493; or Hirst's "Obstetrics" (1909), pages 253 and 247. 7. See Williams' "Obstetrics" (1909), page 282; or Hirst's "Obstetrics" (1909), page 416. 8. See Williams' "Obstetrics" (1909), page 661 ; or Hirst's "Obstetrics" (1909), page 442. . 9. See Williams' "Obstetrics" (1909), page 384. 10. Ophthalmia neonatorum is an infectious, purulent in- flammation of the conjunctiva in the new-born. It is due to the gonococcus or some other pyogenic germ; and is produced by contact of the eye with the vaginal secretion of the mother during labor, or infected fingers, or instruments, etc. The treatment is: (1) Prophylactic: Whenever there is the possibility of infection, or in every case, wash, the eye- lids of the new-born child with clean warm water, and drop ori the cornea of each eye one drop of a one or two per cent, solution of nitrate of silver, immediately after birth. (2) Remedial: Wash the eyes carefully every half hour with a saturated solution of boric acid; pus must not be allowed to accumulate. Two drops of a two per cent, solution of nitrate of silver must also be dropped on to the cornea every night and morning. The eyes must be cov- ered with a light, cold, wet compress. The patient must be isolated, and all cloths and compresses used must be burnt. HYGIENE. I. The principal means of preventing the spread af con- tagious diseases in schools are : Regular and efficient in- spection by physicians; prompt exclusion and isolation of 596 MEDICAL RECORD. anyone suffering from a contagious disease, or coming from a house where such disease is ; compulsory vaccina- tion ; compulsory notification of all infections and con- tagious disease ; individual towels, drinking vessels, and other implements ; children who have had a contagious or infectious disease, or who have come from a house where such disease prevailed, should not be readmitted to school until sufficient time has elapsed since the occurrence of the last case to insure safety. 2. Hygienic precautions to be taken in treating a case of tuberculosis : ''The patient's quarters should be free from dust and admit of spending many hours daily in the open air in all weathers, properly sheltered, and, if very ill, lying wrapped in a hammock or reclining chair. His bed- room should be well aired at night, draughts being avoided. The room should be uncarpeted and free from hangings. It should be often cleaned and periodically disinfected. All sputum should be collected in paper spit-cups, which should be burned daily. Smoking should be forbidden. Harm is done by any exercise which results in fatigue, and while fever exists it should not be attempted at all. Pa- tients should be taught the necessity of practising lung gymnastics and breathing only through the nose, which should be kept clear and free from occlusion by secretions, or a hypertropnied catarrhal mucosa. * * * The cloth- ing should be woolen, but not too heavy, or sweating is increased ; and a flannel nightgown and loosely knit leg- gings should be worn at night in cool weather. The skin should be cleansed by daily sponge baths of lukewarm alcohol and water." — (Thompson's Practical Medicine.) 3. Because diseases may be easily conveyed by such usae-e. 4. Proper instruction of the mothers in the proper method of feeding and caring for infants; proper pro- vision for an adequate supply of good, pure milk and ice, at reasonable prices. See, too, French's "Practice of Medicine" (1907), page 780. 5. Because in the home the individual and his comfort and necessities are studied ; more assistance is present or is obtainable; there is no routine to be kept up; the physi- cians and nurses are selected by the patient and his family, and there is more likelihood of adequate personal attention being given. STATE BOARD EXAMINATION QUESTIONS. South Carolina State Board of Medical Examiners. GENERAL ANATOMY. i. - Name the bones of the head. 597 MEDICAL RECORD. 2. Name the bones of the lower extremity. 3. Name the muscles of the abdomen — deep and super- ficial. 4. What chief arteries supply the neck and head? 5. Where are the epigastric arteries found? Branches of what arteries? REGIONAL OR SURGICAL ANATOMY. 1. In the lymphatics of the peritoneum, which are most rapid in absorption, those of the diaphragm or of the pelvis? If you wish to stimulate in abdominal incision, what position would you place the patient in? If to re- tard too rapid absorption of pus in cavity, what position? 2. What are the anatomical points to be remembered in paracentesis thoracis? 3. From its anatomical position, why is rupture of the kidney of less danger than rupture of the liver and the spleen ? 4. A case presented with apparent dislocation with atrophy of shoulder muscles and arm, only partial mo- tion. What anatomical points would decide between dis- location of the shoulder and paralysis of the deltoid? 5. What nerve supplies the superior oblique muscle of the eye, and what defect of vision would you have in paralysis of the same? What nerve supplies the external rectus ; what would you find in paralysis of that muscle ? 6. What is the most common point of fracture of the humerus? What are some of the sequelae? 7. Give surface marking of the brachial artery. 8. Give surface marking of the femoral artery (common and superficial) ; where best compressed? Where best li- gated? 9. In lateral lithotomy, name anatomical points to be avoided. 10. Give the anatomical position of the deep epigastric artery to direct and indirect hernia. PHYSIOLOGY. 1. What conditions hasten or retard the coagulation of blood, and mention the physical properties of the blood? 2. What produces the second sound of the heart, where best heard, and what events in the heart's action are co- incident with it? 3. What is the difference between warm and cold blooded animals, and how is heat produced and dissemi- nated from the body? 4. How is the secretion of glands chiefly regulated, and how do the kidneys secrete urine? 5. What results would follow a complete division of the right facial nerve? 598 MEDICAL RECORD. CHEMISTRY. i. Give chemical formula for common salt; nitrate of silver; sulphuric acid; nitric acid; water. 2. What is the difference between blue mass, mercurial ointment, and citrine ointment? 3. What is gray powder? 4. What is the difference between static and galvanic electricity? Give methods of production. 5. What are the positive and negative poles of a bat- tery termed? PRACTICAL URANALYSIS, MICROSCOPY, TOXICOLOGY. i. How do you make a chemical analysis of the urine for life insurance? 2. Give indications of high and low specific gravity in the twenty-four hour urine. 3. What does transitory low specific gravity indicate? 4. Give differential morphology of blood, pus, oil and water under the microscope. 5. Describe simple and compound microscopes. 6. What oculars and objectives are in common use? 7. Give symptoms and antidotes to poisoning by sul- phate of atropine. 8. Give symptoms and antidotes to poisoning by opium. 9. How would you detect a case of poisoning with car- bolic acid or potassium hydrate? 10. What fumes are given off by arsenic when it is burned? MATERIA MEDICA. Give the dose and physiological effect of: 1. Fluid extract of ergot. 2. Sulphate of sparteine. 3. Veratrum viride. 4. Chloral hydrate. 5. Tincture of digitalis. THERAPEUTICS. In treating the following diseases, give dose, frequency of administration and physiological effect of drugs used; also other remedial measures used, giving physiological effect and mode of use: 1. Acute articular rheumatism. 2. Acute lobar or croupous pneumonia. 3. Erysipelas. 4. Dysentery. 5. Enterocolitis of children. 6. Dysmenorrhea. 7. Orchitis (non-specific). ' 8. Acute nephritis. 599 MEDICAL RECORD. 9. Acute gastritis. 10. Gastric ulcer. BACTERIOLOGY AND PATHOLOGY. i. What is meant by aerobic bacteria? What is meant by anaerobic bacteria? 2. Name three most important culture media. 3. State briefly the morbid anatomy of catarrhal ap- pendicitis. 4. What connection has typhoid fever with the forma- tion of gallstones? 5. Differentiate between fatty degeneration and fatty infiltration. PRACTICE OF MEDICINE AND DISEASES OF CHILDREN. 1. Differentiate simple melancholia and hypochondria. 2. (a) What are the causes of cardiac arrhythmia? (b) Symptoms and treatment of angina pectoris? 3. (a) What are the possible sequelae of pneumonia? (b) What symptoms would cause you to suspect incipient pulmonary tuberculosis ? 4. Mention the causes of anemia, 5. Symptoms of interstitial nephritis. 6. Symptoms and treatment of acute dysentery. 7. Make diagnosis and give reasons from following history and symptoms : J. S., aged 40 years. He had suffered for years with indigestion, and for several months with pain in epigas- trium, which was relieved by eating, and for one week remained in bed on account of aggravation of epigastric pain. At 1 o'clock in the day got up and went to the back door to look out. While there was seized with sudden se- vere pain in abdomen. He vomited and crawled back to bed. At 3 p.m. his pulse was 90, temperature 101 degrees F., abdomen of board-like rigidity, tenderness everywhere, but more tender in epigastrium. He was given morphine, gr. Y^. At 9 p.m. he was somewhat improved, and his muscular spasm was a little less. At 11 p.m. was pale and looked sick. There was distinct spasm and tenderness in epigastrium, shading off into other regions of abdomen, which was generally retracted. There was no dullness. Tongue moist. Pulse 90, temperature 101 degrees F. 8. Symptoms and sequelae of scarlet fever. 9. What per cent, of fat and proteids would you pre- scribe for a child four months old? How would you direct the mother to make it? 10. Causes of convulsions in children? Causes of vomiting in children? OBSTETRICS AND DISEASES OF WOMEN. i. With what conditions may pregnancy be confounded? 600 MEDICAL RECORD. 2. (a) How does placenta praevia develop? (b) Where does the hemorrhage come from that endangers the moth- er's life? (c) In what way is the child's life endangered in this condition? (d) How would you treat a case of placenta praevia when hemorrhage occurs prior to full term ? 3. How would you treat a case of postpartum hemor- rhage? 4. What are the prodromal symptoms of eclampsia, and what would you do to prevent it? 5. How would you treat a case of prolapse of the arm in a transverse position? 6. How would you treat a case of retained placenta? 7. Under what conditions is a physician justified in inducing premature labor? 8. What symptoms and conditions would cause you to suspect twin pregnancy? 9. How would you perform a curettage after an incom- plete abortion? 10. \Y T hat are the ultimate dangers from gonorrhea in the female? SURGERY. 1. Causes which retard, interfere with, or prevent a wound from healing; (1) in wound itself; (2) in subject of wound; (3) in treatment. 2. To promote the primary union of a wound, name six important factors. 3. When a visible part is inflamed, there are four nota- ble phenomena to be observed; what are they? 4. (1) What causes bedsores? (2) How would you prevent them? (3) When present, how would you treat them? 5. Acute orchitis: (1) Etiology; (2) symptoms; (3) treatment. 6. How would you treat chronic ulcer of the leg? 7. Give symptoms and treatment in downward disloca- tion of the head of the humerus. 8. How would vou treat a simple fracture of the mid- dle third of the femur? 9. Necrosis of the lower third of femur in a boy of twelve years. Give early symptoms and treatment. 10. In amputating the lower third of the leg, give the several steps of the operation, including dressing. PRACTICAL HYGIENE. SANITARY SCIENCE., STATE MEDICINE. 1. State the period of incubation and contagion in c carlet fever, diphtheria, pertussis, measles, rubella, small- pox, typhoid fever, parotitis. 2. What hygienic care should be taken by pregnant and parturient women ? 601 MEDICAL RECORD. 3. What condition would cause you to condemn meat, and what would you do to insure milk from impurities, that is, milk meant for the public? 4. What infectious diseases may be conveyed through the medium of air, water and food, respectively? 5. What are the injurious effects of excessive use of tobacco ? 6. Give draft of acceptable regulations of schools as to contagious diseases. 7. At a moderate temperature what is the most satis- factory relative humidity for comfort? 8. At 80 degrees F. what humidity is uncomfortable? 9. Give hygienic care of infants as to clothing, bath, and their various organs. 10. Name six diseases subject to quarantine, and how long would you quarantine each? MEDICAL JURISPRUDENCE. 1. In what condition would you expect to find the lungs, kidneys and heart after death from asphyxia? 2. What is the difference in the appearance of burns produced before death and those made after death? 3. When a physician takes charge of a case gratuit- ously, is he exempt from tne charge of malpractice if it can be proven that his treatment was improper, or that he neglected his patient? 4. What causes rigor mortis? 5. In women what is the last of the internal organs to putrify? 6. What is the duty of the physician when it is neces- sary for him to take down a dying declaration? 7. In a case of suspected infanticide, describe the method of determining whether the child breathed or not. 8. What is legally meant by feticide? Is the crimini- nality of the act any greater if performed after quickening than before? 9. State briefly the difference between idiocy and mania. 10. In death by lightning, in what condition would you expect to find the heart? In what condition the other internal organs? ANSWERS TO STATE MEDICAL BOARD EXAM- INATION QUESTIONS. South Carolina State Board of Medical Examiners. general anatomy. I. The bones of the head are: Occipital, 2 parietal, 2 temporal, frontal, ethmoid, sphenoid, 2 lacrymal, 2 malar, 602 MEDICAL RECORD. 2 nasal, 2 palate, 2 superior maxillary, 2 inferior turbinate, vomer, and inferior maxillary. 2. Bones of lower extremity: Ilium, ischium, os pubis, femur, tibia, fibula, patella, os calcis, astragalus, cuboid, scaphoid, 3 cuneiforms, 5 metatarsals, and 14 phalanges. 3. Abdominal muscles: External oblique, internal oblique, transversalis, rectus, pvramidalis, quadratus lumborum. 4. Subclavian, carotid (external and internal), superior thyroid, lingual, facial, occipital, posterior auricular, as- cending pharyngeal, superficial temporal, internal maxillary, ophthalmic, anterior meningeal, anterior cerebral, middle cerebral, posterior communicating, arteria princeps cervicis, transverse facial, middle temporal, middle meningeal, lacrymal, frontal, nasal, circle of Willis, vertebral, basilar, posterior meningeal, inferior thryoid, tracheal, ascending cervical. 5. The internal or deep epigastric artery is a branch of the internal iliac; the superficial epigastric is a branch of the femoral artery; the superior epigastric is a branch of the internal mammary artery. REGIONAL OR SURGICAL ANATOMY. i. In the lymphatics of the peritoneum, those of the diaphragm are more rapid in absorption than those of the pelvis. To stimulate, the patient should have the foot of his bed raised, so that the fluid (salt solution) may be con- veyed more readily to the diaphragm, where absorption is more rapid. To retard the too rapid absorption of pus in the ab- dominal cavity, the head of the bed should be raised so that drainage may be directed toward the pelvis, where absorption is slower. 2. In paracentesis thoracis: The puncture should be made in the mid-axillary line, and in the fifth, sixth or seventh spaces ; it should be made midway between the ribs, so as to avoid the intercostal vessels ; it should be made during inspiration, as then the spaces are wider. 3. Rupture of the kidney is of less danger than rup- ture of the liver and the spleen, because the kidney is retroperitoneal, and therefore the peritoneal cavity is not so liable to be infected bv the extravasation. 4. In dislocation of the shoulder: the head of the humerus is not in the glenoid cavity, and motion of the arm is considerably impaired ; in paralysis of the deltoid, the head of the humerus is in the glenoid cavity, and the arm is freely movable. 5. The superior oblique muscle of the eye is supplied by the fourth cranial nerve (the trochlear or patheticus) ; in paralysis of the same diplopia results. The external 603 MEDICAL RECORD rectus is supplied by the sixth cranial nerve (the ab- ducens) ; in paralysis of the same there will result con- vergent strabismus and diplopia. 6. The most common place of fracture of the humerus, is at the lower extremity of the bone. Some of the se- quelce, are: (i) non-union; (2) "gun-stock" deformity; and (3) loss of the "carrying angle." 7. With the arm extended, and the forearm supinated, the brachial artery- is indicated by a line drawn from the anterior axillary fold, along the inner border of the biceps, to the middle of the bend of the elbow-joint. 8. The femoral artery is indicated by a line drawn from the central point of a line joining the anterior superior spine of the ilium and the symphysis pubis to the adductor tubercle on the inner condyle of the femur. The femoral artery is best compressed just below Pou- part's ligament; and it is best ligated at the apex of Scarpa's triangle. 9. In lateral lithotomy, the anatomical points to be avoided, are: (1) The bulb of the urethra, and its artery; (2) the rectum; (3) the pudic artery; (4) complete di- vision of the prostate gland; (5) the left ejaculatory duct. 10. The deep epigastric artery is internal to indirect inguinal hernia; and external to direct inguinal hernia. PHYSIOLOGY. 1. Conditions which hasten the coagulation of the blood are: (1) Moderate warmth, (2) contact with foreign mat- ter, (3) agitation, (4) the presence of calcium salts. Conditions retarding the coagulation of the blood are : (1) A low temperature, (2) the addition of neutral salts in large quantities, (3) contact with oil, (4) contact with the living vessel walls, (5) when mixed with an oxalate, (6) the injection of peptones or lead extract. The physical properties of blood: Fluid, somewhat vis- cid, red, specific gravity from 1055 to 1062, alkaline reac- tion, saltish taste, characteristic odor, variable temperature (average about 100 degrees F.). 2. The second sound of the heart is caused by the vi- brations due to the closure of the semilunar valves. It is best heard at the base of the heart, over the second right costal cartilage. The events in the heart's action coincident with the sec- ond sound, are: (1) The closure of the semilunar valves; (2) the continued dilatation of the auricles; (3) the begin- ning of the dilatation of the ventricles ; (4) the opening of the auriculoventricular valves. 3. Warm-blooded animals are those whose body tem- perature remains almost constant. Cold-blooded animals are those whose body tempera- 604 MEDICAL RECORD. ture varies with that of the surrounding medium, but which is always a little above that of the medium. The heat of the body is maintained by the thermotactic centers in the brain and cord keeping an equilibrium be- tween the heat gained or produced in the body and the heat lost. Heat is produced in the body, by: (i) Muscular action; (2) the action of the glands, chiefly of ^ the liver; (3) the food" and drink ingested; (4) the brain; (5) the heart; and (6) the thermogenetic centers in the brain, pons, medulla, and spinal cord. Heat is given off from the body, by: (1) The skin, through evaporation, radiation, and conduction ; (2) the expired air; (3) the excretions — urine and feces. 4. The secretion of glands is chiefly regulated by: (1) The variations in the quantity of blood which the gland receives; (2) the nerve impulses to the gland. The mechanism of the secretion of urine by the kidneys is twofold: (1) By filtration, most, if not all, of the fluid is eliminated, and also inorganic salts; this depends upon blood pressure, and takes place in the glomeruli. (2) By cell activity and selection, in the cells of the con- voluted tubules, the urea and principal solids are elimi- nated. 5. When the facial nerve is divided, paralysis of the facial muscles ensues, and "the muscles of the face be- ing all powerless, the countenance acquires on the para- lyzed side a characteristic, vacant look, from the absence of all expression; the angle of the mouth is lower, and the paralyzed half of the mouth looks longer than that on the other side ; the eye has an unmeaning stare, owing to the paralysis of the orbicularis palpebrarum. All these peculiarities increase the longer the paralysis lasts, and their appearance is exaggerated when at any time the muscles of the^ opposite side of the face are made active in any expression, or in any of their ordinary functions. In an attempt to blow or whistle, one side of the mouth and cheeks acts properly, but the other side is motionless, or flaps loosely at the impulse of the expired air; so, in trying to suck, one side only of the mouth acts ; in feeding, the lips and cheek are powerless, and, on account of paralysis of the buccinator muscle, food lodges between the cheek and gums." — (Kirkes* Physiology.) CHEMISTRY. 1. Chemical formula, for common salt, is NaCl; for nitrate of silver, AgN0 3 ; for sulphuric acid, H2SO4; for nitric acid, HNO s ; for water, H 2 0. 2. Blue mass contains 33 per cent, of mercury; mer- 605 MEDICAL RECORD. curial ointment contains 50 per cent, of mercury; and citrine ointment contains 7 per cent, of mercury. 3. Gray powder is Hydrargyrum cum Creta, or mer- cury with chalk, and contains 38 per cent, of mercury. 4. Static electricity is produced by friction; galvanic electricity is produced by chemical action in a galvanic cell. t( Static or frictional electricity is generated for practical purposes by an electric machine, consisting essentially of a plate or wheel of glass, or some similar substance, revolved by a mechanical contrivance against some material capable of producing positive electricity on the plate. This posi- tive charge is carried from the plate by metal combs or rods to the prime conductor; the negative generated on the rubbing cushions may be collected on a conductor, but is generally carried to the ground by a chain." Galvanic electricity: "Zinc placed in a vessel containing dilute sulphuric acid is gradually dissolved, evolving hydro- gen gas. Platinum is not acted on by dilute sulphuric acid. If plates of both metals be placed in sulphuric acid and water, and connected by a piece of wire as a conductor, no bubbles of gas are evolved on the zinc, but escape from the platinum plate. If the wire be placed near a magnetic needle this will be turned from its course (deflected) ; when the ends of the divided wire touch the tongue a ting- ling and metallic taste are perceived. All these phenomena disappear if the connection between the plates is broken, and reappear when restored^ and are manifestations of electricity generated by the action of the acid on the metals, traveling through the wire to which it imparts its proper- ties. The zinc, platinum, and sulphuric acid may be re- placed bv many other materials. Electricity will be gener- ated whenever two solid conductors, usually in plate or cylinder form, are connected by a conductor, and placed in a liquid having the power of acting chemically on one of them. Such an arrangement is called a voltaic or gal- vanic cell ; the liquid the electrolytic or exciting agent ; and the solids the electrodes; and all are called the elements of the cell. In a galvanic cell the electrolytic agent is split into two parts, called ions ; and these ions, charged with + and — electricity, respectively, unload the charges on the plates. The conductor restores the electrical equilibrium. In the zinc, platinum, and sulphuric acid cell the acid is split up into hydrogen and S0 4 , the H 2> escapes from the platinum plate while the S0 4 combines with the zinc, form- ing zinc sulphate, which dissolves in the water." — (McGlan- nan's Epitome of Chemistry.) 5. The positive pole of a battery is termed the anode; the negative pole is termed the cathode. 606 MEDICAL RECORD PRACTICAL URANALYSIS, MICROSCOPY, TOXICOLOGY. 1. In examining normal urine the following points are to be considered : The quantity voided in twenty-four hours, its general appearance, color, odor, reaction, specific gravity, quantity of solids excreted, quantity of urea, uric acid, chlorides, sulphates, phosphates. In abnormal urine, in addition to the above, examina- tion should be made for albumin, sugar, excess of indican, acetone, blood, bile, pus, casts, epithelium, parasites, patho- genic bacteria, and foreign bodies. 2. High specific gravity of the urine, may indicate : Diabetes mellitus, fevers, and chronic parenchymatous nephritis. Low specific gravity of the urine, may indicate : Diabetes insipidus, chronic interstitial nethritis, contracted kidney, some nervous disorders, albuminuria, hysteria. 3. Transitory low specific gravity may indicate : Hys- teria, or some nervous disorders, or the ingestion of an abnormal amount of fluids. 4. Blood is yellowish, and shows the corpuscles (both colored and colorless). Pus is opaque, and shows the pus corpuscles and gran- ules. Oil is homogeneous, clear, and may be transparent. Water is homogeneous, clear, colorless, and transparent. 5. A Simple Microscope. "With this an enlarged, erect image of an object may be seen. It always consists of one or more converging lenses or lens-systems, and the object must be placed within the principal focus. The simple microscope may be held in the hand or it may be mounted." A Compound Microscope. "This enables one to see an enlarged, inverted image. It always consists of two optical parts, an objective, to produce an enlarged, inverted, real image of the object, and an ocular, acting in general like a simple microscope to magnify this real image. There is also usually present a mirror, or both a mirror and some form of condenser or illuminator for lighting the object. The stand of the microscope consists of certain mechanical arrangements for holding the optical parts and for the more satisfactory use of them." — (Gage's The Microscope.) 6. Oculars in common use, are : Those having a mag- nification of 5. 7.5, 10, 12.5, and 15 times. Objectives in common use, are: Dry: 2 inches, 1% inches, %-inch, %-inch, 1/6-inch and Ms-inch; (2) Immer- sion: 1/12-inch and 1/16-inch. 7. Symptoms of poisoning by sulphate of atropine: 607 MEDICAL RECORD. Dryness of the mouth and throat, thirst, drowsiness, dys- phagia, face flushed, pupils much dilated, eyes prominent, numbness and partial paralysis of the extremities, and there may be delirium and coma. Antidotes: Pilocarpine and morphine are physiological antidotes. 8. Opium poisoning: Symptoms: In opium poisoning there may be three stages: (i) a period of excitement, in which the patient is active, talkative, and has hallucina- tions ; (2) a period of drowsiness, in which the patient is sleepy, but may be aroused ; his face is pale, lips livid, pupils contracted; this passes into (3) the stage of coma, from which the patient cannot be aroused; reflexes are abolished, pupils are contracted, the pulse is slow and irregular, and respirations are infrequent and shallow. Treatment consists in washing out the stomach, prefer- ably with a dilute solution of potassium permanganate ; ambulatory treatment, to keep the patient awake ; artificial respiration is indicated, and strong coffee should be ad- ministered by the mouth or rectum; the bladder should be emptied by the catheter. There is no antidote. 9. Carbolic acid poisoning may be detected by the white and corrugated mucous membrane of the mouth ; the dark or smoky urine ; the brown spots wherever the carbolic acid came in contact with the skin; the odor of phenol. Poisoning by potassium hydrate may be detected by the : sloughing of the mucous membrane of mouth and eso- phagus ; the stomach contents are alkaline, soapy and frothy; on warming the stomach contents there is no odor of ammonia. 10. When arsenic is heated in air, it is converted into arsenic trioxide. MATERIA MEDICA. i. Fluid Extract of Ergot. Dose: r$. xxx. Physiological effect: It stimulates and causes contrac- tion of involuntary muscle fibers, hence it is a. vasocon- strictor, hemostatic, and oxytocic. It is also a cardiac sedative, it raises the blood pressure, it increases peristal- sis, and is an emmenagogue. 2. Sulphate of Sparteine. Dose: gr. 1/5. Physiological effect: It increases the force of the heart, paralyses the respiratory and motor centers, and increases the flow of urine. 3. Veratrum Viride. Dose: gr. ij. Physiological effect: It reduces body temperature, re- duces arterial pressure, is a respiratory depressant, relaxes 608 MEDICAL RECORD. voluntary and cardiac muscle, causes gastrointestinal irri- tation and diaphoresis. 4. Chloral Hydrate. Dose: gr. xv. Physiological effect: It is a hypnotic and antiseptic, it is a cardiac respiratory depressant, and it lowers the blood pressure and body temperature. 5. Tincture of Digitalis. Dose: Tl#. xv. Physiological effect: It is a gastrointestinal irritant, it slows the rate of the heart, prolongs diastole, increases the force of the heart, it contracts the blood-vessels and causes a rise in blood pressure, it also acts as a diuretic. THERAPEUTICS. 1. See French's "Practice of Medicine" (1907), page 230; or Osier's "Practice of Medicine" (1909), page 226. 2. See French's "Practice of Medicine" (1907), page 174; or Osier's "Practice of Medicine" (1909), page 189. 3. See French's "Practice of Medicine" (1907), page 221; or Osier's "Practice of Medicine" (1909), page 213. 4. See French's "Practice of Medicine" (1907), page 258; or Osier's "Practice of Medicine" (1909), pages 6 and 246. 5. See French's "Practice of Medicine" (1907), pages 781 and 785; or Osier's "Practice of Medicine" (1907), page 6. Dysmenorrhea: The treatment is directed toward any existing constitutional condition, and pain is relieved by hyoscin, chloral, bromids, etc. Anteflexion and stenosis will require dilatation of the cervix. Endometritis usually needs curetment. Pelvic inflammation requires appropriate treatment. 7. See Rose and Carless' "Surgery" (1908), page 1258; or Da Costa's "Surgery" (1908), page 1198. 8. See French's "Practice of Medicine" (1907), page 895; or Osier's "Practice of Medicine" (1909). page 690. 9. See French's "Practice of Medicine" (1907), page 738; or Osier's "Practice of Medicine" (1909), page 463. 10. See French's "Practice of Medicine" (1907), page 751; or Osier's "Practice of Medicine" (1909), page 477. BACTERIOLOGY AND PATHOLOGY. i. Aerobic bacteria are such as require the presence of oxygen as an essential to their growth. Anaerobic bacteria are such as require the absence of oxygen as an essential to their growth. 2. Three most important culture media: Bouillon, gela- tin, and agar-agar. 3. In catarrhal appendicitis: The musoca will be found swollen and eroded, granulation tissue may be found; the muscularis is thickened and edematous; the serosa is con- gested and edematous but not extensively; the contents 609 MEDICAL RECORD. are more or less mucopurulent and are retained in the appendix. 4. The typhoid bacilli find their way to the gall blad- der, and there cause a catarrhal inflammation which modi- fies the chemical composition of the bile and brings about first an excessive secretion and then a precipitation of cholesterin and salts. These latter, with the bacilli and epithelial debris tend to cause gall-stone formation. 5. In fatty degeneration the fat is formed by changes in the protoplasm of the cells; while in fatty infiltration the fat is brought by the blood to the cells, and is there deposited. PRACTICE OF MEDICINE AND DISEASES OF CHILDREN. i. Melancholia "is a variety of mental alienation, charac- terized by more or less profound depression, with either no marked intellectual disturbance or the presence of more or less incoherence, and hallucinations and delusions. ^ The cerebral mechanism develops a condition of supersensitive- ness, all impressions being exaggerated, and a state of ab- normal self-consciousness existing." Hypochondria "is a peculiar mental condition, charac- terized by inordinate attention on the part of the patient to some real or supposed bodily ailment or sensation." — (Hughes' Practice of Medicine.) 2. (a) Cardiac arrhythmia has no particular clinical significance, unless it accompanies some disease. Accord- ing to Butler (Diagnostics of Internal Medicine), search should be made for one or more of the following: (1) Valvular cardiac disease, especially mitral lesions, in which it is usually, but not always, a sign of beginning failure of compensation, passing in many instances into delirium cordis; simple dilatation, chronic myocarditis, sclerosis of the coronary arteries, and fatty degeneration ; possibly ob- scure changes in the cardiac ganglia, and overstrain or impaired nutrition in wasting diseases or long-continued fevers. (2) Poisons circulating in the blood, such as al- cohol, coffee, tea, tobacco, digitalis, aconite, and belladonna, or the toxins of the infectious diseases, especially of ty- phoid fever and pneumonia. (3) Diseases of the intracra- nial contents, meningitis, hemorrhage, abscess, softening, concussion, and not infrequently mental excitement. (4) Neurasthenic conditions resulting from excesses or over- strain. Brief attacks of moderate arrhythmia are not un- common in neurotic individuals, following even a slight departure from their usual habits in food, drink, or exer- tion. (5) Digestive disturbances, acute or chronic, and jaundice or constipation, particularly if associated with an unusually hypochondriacal frame of mind. (6) More 610 MEDICAL RECORD rarely arthritis deformans, exophthalmic goiter, and renal disease. (b) The symptoms of true angina pectoris are: Excru- ciating pain radiating from the heart to the neck, shoulder and arm (generally the left) ; a sense of impending death; cardiac constriction; the face is anxious and pale; cold perspiration and sometimes dyspnea. The treatment: Inhalation of 3 to 5 minims of amyl nitrite; spirit of nitrous ether, or morphine (gr. ]/ A hypo- dermatically), or inhalation of chloroform may be given; heat may be applied over the region of the heart, and stimulants should be given after the attack. During the intervals severe mental or muscular exercise must be avoided. 3. (a) The possible sequelce of pneumonia, are : Chronic pneumonia, gangrene of the lung, phthisis, empyema, nephritis. (b) Incipient pulmonary tuberculosis may be suspected from: (1) Physical signs: Deficient chest expansion, the phthisical chest, slight dullness or impaired resonance over one apex, fine moist rales at end of inspiration, expiration prolonged or high pitched, breathing interrupted. (2) Symptoms: General weakness, lassitude, dyspnea on ex- ertion, pallor, anorexia, loss of weight, slight fever, and night sweats, hemoptysis. 4. The causes of anemia, are as follows: (1) Of the primary anemias: The cause is unknown, probably it is some form of intoxication. Predisposing causes are : In- sufficient and improper food; nervous disturbances, such as violent shock ; pregnancy and lactation ; gastrointestinal diseases, such as atrophy of the stomach and interstitial gastritis; parasitic diseases, such as ankylostomiasis and bothriocephaliasis ; frequently repeated hemorrhages; gen- eral diseases, infectious diseases, and intoxications. (2) Of the secondary anemias: Bad hygienic surroundings, as insufficient food or food of bad character, inspiration of noxious gases, overwork and crowding; parasitic diseases; exhausting diseases, as cardiac, renal, or gastrointestinal diseases, cirrhosis of the liver, rickets, scurvy; chronic in- fectious diseases, as tuberculosis, syphilis, leprosy, malaria ; frequently repeated small losses of blood; overlactation and gestation; toxemia, as Saturnism, mercurialism, and jaundice. — (From Macfarland's Pathology.) 5. See French's "Practice of Medicine" (1907), page 903; or Osier's "Practice of Medicine" (1909), page 697. 6. See French's "Practice of Medicine" (1907), pages 252, 2$4, and 258; or Osier's "Practice of Medicine" (1909), pages 5 and 244. 7. The diagnosis is gastric ulcer with perforation.— 611 MEDICAL RECORD (From Cabot's Case Teaching in Medicine, from which the question is taken.) 8. See French's "Practice of Medicine" (1907), pages 317 and 320; or Osier's "Practice of Medicine" (1909), pages 132 and 134. 9. For a child four months old, 4 per cent, of fat and 1.5 per cent, of proteid should be prescribed. Take the upper 15 ounces from a quart of milk 16 hours after milking; add. 6y 2 teaspoonfuls of milk sugar, 4 ounces of lime water, filtered water enough to make one quart. Give 5 to 6 ounces at each feeding. — (From Winters.) 10. Causes of Convulsions in children, are : Overeating, especially of indigestible food; rachitis, debility from ex- hausting diarrheal diseases ; high fever, especially at the onset of the acute specific infections; very seldom denti- tion, phimosis, and acute middle-ear inflammation; injuries to the brain at birth, infantile hemiplegia, meningitis, and tumor of the brain; rarely of spinal cord disease.— (From Butler's Diagnostics of Internal Medicine.) Causes of vomiting in children, are: An overloaded stomach; acute gastric indigestion; acute intestinal ob- struction ; the onset of the acute infectious diseases, as scarlet fever, malaria, pneumonia; toxemia, peritonitis; acute meningitis ; cerebral tumor. OBSTETRICS AND DISEASES OF WOMEN. 1. Conditions with which pregnancy may be confounded, are: Retained menses, ovarian tumors or cysts, uterine fibroids, ascites, obesity, hematometra, physometra, hydro- metra, tympanites, subinvolution of uterus, retroversion of uterus, pseudocyesis. 2. See Williams' "Obstetrics" (1909), pages 811, 813, 814, and 815; or Hirst's "Obstetrics" (1909), pages 574, 576, and 577. 3. See Williams' "Obstetrics" (1909), page 821; or Hirst's "Obstetrics" (1909), page 587. 4. Eclampsia. The symptoms are: "Headache, nausea, and vomiting, epigastric pain, vertigo, ringing in the ears, flashes of light or darkness, double vision, blindness, deaf- ness, mental disturbance, defective memory, somnolence ; symptoms easily explained by the circulation of toxic blood through the nerve centers. These may be preceded by lassitude, and accompanied by constipation, or by diar- rhea. Headache is perhaps the most significant and com- mon warning symptom. In bad cases the urine is reduced in quantity (almost suppressed), very dark in -color, its albumin greatly increased, so that it becomes solid on boiling. Next comes the final catastrophe of convul-. sions. The convulsive fit begins with twitching of the facial muscles, rolling and fixation of the eyeballs, puck- 612 MEDICAL RECORD ering of the lips, fixation of the jaws, protrusion of the tongue, etc., soon followed by violent spasms of the mus- cles of the trunk and limbs, including those of respiration; hence lividity of the face and stertorous breathing, biting of the tongue, opisthotonus, etc. The fit lasts fifteen or twenty seconds, ending in partial or complete coma, pos- sibly death; or consciousness may return, to be followed by other convulsions." — King's Manual of Obstetrics.) Preventive Treatment: (i) The amount of nitrogenous food should be diminished to a minimum; (2) the produc- tion and absorption of poisonous materials in the intestines and body tissues should be limited and their elimination should be aided by improving the action of the bowels, the kidneys, the liver, the skin, and the lungs; (3) the source of the fetal metabolic products and the peripheral irrita- tion in the uterus should, if necessary, be removed by evacuating that organ. 5. See Williams' "Obstetrics" (1909), page 804. 6. See Williams' "Obstetrics" (1909), pages 301 and 477; or Hirst's "Obstetrics" (1909), page 435. 7. Conditions warranting the induction of premature labor: (1) Certain pelvic deformities, (2) placenta prsevia, (3) pernicious anemia, (4) toxemia of pregnancy, (5) habitual death of the fetus toward the end of pregnancy, (6) hydatidiform mole, (7) habitually large fetal head. 8. Twin pregnancy may be diagnosed by the following signs: (1) The abdomen may be irregular in shape and may show a sulcus indicating the space between the two fetal sacs; (2) persistent and increased tension of the uterine walls; (3) two fetal heart sounds may be heard; (4) multiplicity of small parts ; (5) two fetal heads or backs may be palpated; (6) diminished fetal mobility. Sometimes it is difficult to diagnose the condition before the birth of one child. 9. Curettage. Dangers: Sepsis, perforation of uterus, hemorrhage, abortion, inflammation of uterus, or adnexa. Procedure: All antiseptic and aseptic precautions are necessary, the patient should be in the dorsal position, the vagina is to be disinfected, and the cervical canal dilated; a speculum is introduced into the vagina and the cervix is drawn down with volsella ; the uterine cavity is irri- gated with creolin or lysol ; a curette is inserted to the fundus and moved down to the internal os ; the operator should begin at one cornu and go in the same direction all around till he reaches the starting point, and if neces- sary repeat till no more spongy or hyperplastic tissue ap- pears ; the fundus should be scraped separately by moving the curette along it from side to side ; in going towards the tundus no scraping should be done, and care must be "taken not to perforate the uterus ; should this happen 613 MEDICAL RECORD. no fluid must be injected; otherwise the uterus and va- gina are again irrigated, and one or more strips of iodo- form gauze are inserted into the cavity to act either as a hemostatic plug or as a drain, which is diminished with two days' interval and withdrawn on the sixth day. A hemostatic tampon should be placed in the vagina and withdrawn the following day. If any fever arises, the tam- pon is at once removed and the vagina douched with anti- septic fluid every three hours. If not, the vagina is only swabbed with the same every day, and packed loosely with iodoform gauze. After the final removal of the gauze the antiseptic douche is given twice a day until there is no more discharge. The patient should remain in bed for a week. 10. Gonorrhea. Possible results: Cystitis, urethritis, vul- vitis, endometritis, salpingitis, septic peritonitis, sterility, condylomata of vulva, abscess of Bartholin's glands. surgery. i and 2. Six important points to promote primary union of a wound: (i) Stop the bleeding; (2) remove foreign bodies; (3) asepticize; (4) coapt the edges; (5) provide for drainage (if necessary) ; (6) rest the injured part. Any interference with the above will retard, interfere with, or prevent the healing of the wound. 3. Four notable phenomena in inflammation of a visible part: (1) Redness; (2) swelling; (3) heat; (4) tender- ness. 4. Bedsores, (i) Causes: Undue pressure and irri- tating secretions; a crease or fold in a sheet, a crumb of bread, a feather, or a bit of string on the sheet may cause them. Especially is this so when the skin is irritable from excessive perspiration, inefficient washing, or invol- untary passages of urine. Bedsores are particularly com- mon in spinal affections and in wasting diseases. (2) Prevention consists in reducing the pressure, care- ful repeated washing, drying, and dusting with zinc oxide, and subsequent protection with lint or cotton-wool, etc. Leather-backed adhesive plaster may be applied over bony prominences, or, if seen early, collodion may be used. Frequent rubbing with alcohol may prove a preventive. When congestion appears, a water-bed or air-cushion may be used. Spirits of camphor or glycerol of tannin may be rubbed in twice daily, to harden the skin. Salt and alcohol (two drams to the pint) may also be used. (3) Treatment: A solution of silver nitrate may be used when the skin is about to break, in the strength of gr. 20 to the ounce; and in solution of gr. 10, daily, when the skin breaks. The sloughs should be removed as fast as they form. Stimulation, good nourishment, and sleep 614 MEDICAL RECORD. are valuable in treatment. — (From Gould and Pyle's Cy- clopedia of Medicine and Surgery.) 5. See Rose and Carless' "Surgery" (1908), page 1257; or Da Costa's "Surgery" (1908), page 1198. 6. See Rose and Carless' "Surgery" (1908), page 93; or Da Costa's "Surgery" (1908), pagre 159. 7. See Rose and Carless' "Surgery" (1908), page 620; or Da Costa's "Surgery" (1908), page 589. 8. See Rose and Carless "Surgery" (1908), page 546; or Da Costa's "Surgery" (1908), page 490. 9. See Rose and Carless' "Surgery" (1908), page 574; or Da Costa's "Surgery" (1908), page 437. 10. See Rose and Carless' "Surgery" (1908), pages 1313 and 274; or Da Costa's "Surgery" (1908), page 1219. PRACTICAL HYGIENE, SANITARY SCIENCE, STATE MEDICINE. 1. See French's "Practice of Medicine" (1907) ; or Os- ier's "Practice of Medicine (1909), Index, under name of "Disease." 2. See Williams' "Obstetrics" (1909), pages 199 and 340; or Hirst's "Obstetrics" (1909), pages 188 and 364. 3. Meat should be condemned which has any of the fol- lowing diseases : Tuberculosis, actinomycosis, glanders, anthrax, swine-fever, contagious pleuro-pneumonia, septi- cemia, cattle plague, and several parasitical diseases. For milk: The inspection should include: the color, re- action, specific gravity, sediment, taste, odor, total quan- tity of solids and of water; the percentage of cream, fats, lactose, casein, and ash; the presence or absence of preser- vatives, coloring matter, added solids, and dilution. There should also be thorough investigation as to its source, the cows and their environment, the method employed in car- ing for, milking, storing and transporting the milk. 4. Infectious diseases which may be conveyed through the medium of the air: Tuberculosis, pneumonia, diphthe- ria, measles, scarlet fever, whooping cough, erysipelas, influenza. Through the medium of water: Typhoid, dysentery, cholera, yellow fever, scarlet fever, diphtheria. Through the medium of food: Tuberculosis, diphtheria, typhoid, scarlet fever, cholera. 5. "The continued use of tobacco, by smoking or chew- ing it to excess, produces granular inflammation of the fauces and pharynx, atrophy of the retina, dyspepsia, low- ered sexual power, sudden faints, nervous depression, car- diac irritability, and occasionally angina pectoris. Used by the young, it hinders the development of the higher nerve centers and impairs the nutrition of the body by in- terfering with processes of digestion and assimilation." — (P.otter's Materia Medico, etc.) 615 MEDICAL RECORD. 6. The principal means of preventing the spread of con- tagious diseases in schools are : Regular and efficient in- spection by physicians; prompt exclusion and isolation of anyone suffering from a contagious disease, or coming from a house where such disease is; compulsory vaccination; compulsory notification of all infections and contagious disease; individual towels, drinking vessels, and other im- plements ; children who have had a contagious or infectious disease, or who have come from a house where such disease prevailed, should not be readmitted to school until suffi- cient time has elapsed since the occurrence of the last case to insure safety. 7. Between 70 and 80 per cent, relative humidity. 8. Anything above 77.5 per cent, relative humidity. 9. See Williams' "Obstetrics" (1909), page 347; or Hirst's "Obstetrics" (1909), page 928. 10. See Question and Answer 1. MEDICAL JURISPRUDENCE. 1. After death from asphyxia, I would expect to find the lungs, kidneys, and heart, congested. Occasionally, in young persons, the lungs are anemic and emphysematous; the right side of the heart and lungs is usually gorged with dark-colored blood. 2. In burns produced before death: there is usually a blister, with a bright, red base, and containing a serous fluid, which is albuminous ; occasionally, there will be no blister if there has been excessive shock; also, there will be a red line of demarcation between the injured and the uninjured parts, and this, being a vital process, is only de- veloped during life. In burns produced after death there is no true blister, no red base, and gas is present in place of serous fluid. 3. Taking charge of a case gratuitously causes no ex- emption from the charge of malpractice, in case of neglect or improper treatment. 4. Rigor Mortis is supposed to be due to the coagula- tion of the myosin in the muscles. 5. In women, the last of the internal organs to putrefy, is the uterus. 6. The duty of the physician, when it is necessary for him to take down a dying declaration, is: (1) To explain to the patient the hopelessness of the case; (2) to satisfy himself as to the patient's soundness of mind; (3) to write down the exact words of the dying person, without adding any comment or explanation of his own ; (4) to read the declaration over to the dying person, and, if pos- sible, have him sign it; (5) the statement should be per- fectly voluntary. 7. Application of Hydrostatic Test. — Having opened 616 MEDICAL RECORD. chest, note position of lungs (before respiration they occupy a small space at upper and posterior parts of thorax) ; their volume (of course increased after breathing) ; their shape (before respiration, borders sharp or pointed; after it. rounded); their color (before breathing, brownish-red: after it, pale red or pink) ; their appearance as regards dis- ease and putrefaction; and whether they crepitate on pres- sure (as they will after respiration). '"Take out lungs, with heart attached, and place them in pure water having temperature of surrounding air. Note whether they float (high or low), or sink (slowly or rapid- ly). Separate them from the heart; weigh them accurately, and then place them in water again, and note sinking or floating as before. Subject each lung to pressure with the hand, and note sinking or floating again. Cut each lung in pieces and test floating again. Take out each piece, wrap it in a cloth, and compress with fingers as hard as possible, and test floating, etc., as before. The crucial test of perfect respiration is each piece floating after the most vigorous compression;" — (King's Manual of Obstetrics.) 8. By feticide is meant the unlawful destruction of a fetus before it is born. The criminality is the same whether done before or after quickening. 9. "Idiocy differs from other states of insanity in the fact that it is marked by a congenital deficiency of the mental faculties. There is not here a perversion or a loss of what has once been acquired, but a state in which, from defective structure of the brain, the individual has never been able to acquire any degree of intellectual power to fit him for his social position. It commences with life and continues through it." — (Taylor's Medical Jurisprudence.) 10. In death by lightning: the heart may be (1) un- altered, or (2) congested, or (3) full of blood, or (4) empty. The other internal organs are congested. STATE BOARD EXAMINATION QUESTIONS. Board or Medical Examiners of South Dakota. anatomy. 1. Give the fundamental principles of an animal cell. Describe briefly four classifications of cells. 2. What is cartilage? Name and describe the several kinds. 3. Define : Mulberry mass, primitive streak, ectoderm. What structures are formed from the mesoblastic layer? 4. Describe a complete uriniferous tubule, showing the blood supply and various kinds of epithelium. 617 MEDICAL RECORD. 5. Give origin and insertion: Psoas magnus; Serratus magnus; Teres major; Deltoid. 6. Give a description of the arteries and veins of the rectum. 7. Describe and trace the course of the lymphatics of the mammary gland. 8. What displacement occurs in an intracapsular fracture of the femur? Why? 9. Name and describe the ligaments of the knee joint. 10. Describe a hepatic lobule. PHYSIOLOGY. 1. Where, in the human body, are the following sub- stances found? (a) Fibrin; (b) mucin; (c) leucin; (d) chondrin. 2. Describe the nervous mechanism of muscular con- traction. 3. Define stammering, and state the cause. 4. Describe the blood, and compare arterial with venous blood. 5. What is the physiologic function of the liver? 6. What is the rate of circulation of the blood in the (a) arteries, (b) veins, (c) capillaries? 7. Describe the physical properties of (a) lymph, and (b) chyle. 8. Define reflex nervous impulses, and give examples. 9. Explain the difference between human and cows' milk. 10. Define secretion, and name some of its products. CHEMISTRY. 1. (a) What is chemistry? (&)W r hat is meant by chem- ical force or affinity? 2. (a) Give a definition of a crystallized substance, (b) Under what condition will matter crystallize ? 3. What is meant by the terms amorphous, polymorphous, isomorphous? 4. (a) Explain the term quantivalent. (b) Mention some univalent, bivalent, trivalent, and quadrivalent ele- ment. 5. If a certain volume of hydrogen weigh twenty grains, how much will a like volume of oxygen weigh ? 6. State the difference between inspired and expired air, and explain how this is brought about. 7. Give chemical composition and general properties of bismuth subnitrate. Explain the dark color of the stools following its therapeutic use. Name its most dangerous impurity and give test for same. 8. (a) What substances might be indicated if a specimen of neutral or slightly acid urine show a precipitate upon boiling? (b) How would you differentiate between them? 618 MEDICAL RECORD. 9. (a) Give a test to detect sugar in the urine. (&) Give in detail a quantitative test for sugar in the urine. 10. State if the following prescription is chemically com- patible. If not, why? Tinct. ferri chloridi, 3vi. Ext. buchu fl., 3s s. Potassi citratis, 3vi. Aquae dest. qs. ad, 3iv. M. et. Sig. Take a teaspoonful every four hours with a glass of water. BACTERIOLOGY. 1. What is understood by ptomains? Toxins? 2. How do bacteria multiply? 3. When called to a case where diphtheria is suspected, describe fully the technique of taking a culture ; the prefer- able culture medium and stain, and process of staining. 4. Name three conditions essential to bacterial growth. What are the most common microorganisms of suppura- tion? 5. What is the supposed microorganism of cerebrospinal meningitis? How is the bacteriological diagnosis of this disease made? PATHOLOGY. 1. Contrast hyperemia and passive congestion. 2. What is the pathology of arteriosclerosis? 3. Define osteomyelitis. 4. Give the technique of an examination of the sputum. 5. Give a brief outline of Ehrlich's side chain theory. 6. Describe "healing by second intention." 7. Give causes, symptoms, macroscopic, and microscopic findings in atrophic cirrhosis of the liver. 8. Define embolus, thrombus. 9. Give the pathology of urticaria. 10. Name three forms of nucleated red blood cell. PRACTICE AND THERAPEUTICS. 1. What are the clinical forms of acute gastrointestinal catarrh of childhood? 2. What is varicella? Variola? Give differential diag- nosis of same. _ 3. Define idiopathic anemia. Give symptoms. Differen- tiate idiopathic anemia and progressive pernicious anemia. 4. What is acute chorea? Give pathology, symptoms and treatment. 5. Describe neurosis of bladder. Give symptoms and treatment. Jn what way does neurosis of bladder differ from cystitis? 619 MEDICAL RECORD. 6. What is ascites? Give symptoms, physical signs, and treatment. What is liable to be mistaken for it? 7. Define bronchopneumonia. Lobar pneumonia. Give differential diagnosis. 8. (a) What are the modes of administering drugs? (b) Give therapeutic uses and contraindications of chloral hydrate. 9. Give symptoms of intestinal obstruction and name the different types- 10. Give therapeutic uses and contraindication of digitalis. Describe poisoning from digitalis. OBSTETRICS. 1. Describe ovulation. 2. Describe a case of pregnancy at beginning of fourth month. 3. When would you apply the forceps? When would you not apply the forceps? 4. Give causes, symptoms, and dangers of a premature detachment of the placenta, and treatment. 5. Phlegmasia alba dolens. Give symptoms, treatment, and results. 6. What precautions do you take to prevent rupture of the perineum? If considerably torn, what do you do, when and how? 7. With right shoulder presenting, arm straight, and hand born, palm of the hand facing the right thigh of mother, thumb backward, what would be position of child in utero, and what would you do? 8. What is meant by the "stages of labor"? 9. How would you prevent mastitis? 10. Describe care of the mother for first three days after the birth. DISEASES OF WOMEN. 1. Describe the contents of the female pelvic cavity, and show relations. 2. Give treatment in detail of a submucous fibroma. 3. Give the symptoms and treatment of a chronic retro- version of the uterus; (a) medical; (b) surgical, giving details of one operation. 4. Etiology and treatment of (a) cystocele ; (b) rectocele. 5. Etiology, symptoms, and treatment of pelvic adhesions. SURGERY. 1. Diagnose and treat a case of acute serous synovitis in its most frequent location. 2. Describe a case of cellulitis of the hand. Give treat- ment for same. What does it often accompany? 3. Give cause and treatment of varicose veins of the lower extremities. 620 MEDICAL RECORD. 4. Give the most common seat of fracture of the inferior maxillary, and its treatment. 5. Give cause and treatment for hallux valgus. 6. Describe Bassini's operation for the radical cure for inguinal hernia. 7. Diagnose a movable kidney. What operation would you perform for its relief? Describe the operation. 8. Diagnose an ischiorectal abscess. Give etiology and treatment. 9. Name the most common dislocation of the shoulder joint and give method of reduction. 10. Describe an operation for the radical cure of hydro- cele. EYE AND EAR. 1. (a) Give diagnosis of iritis, (b) Name, describe, and treat five common pathological conditions of the eye. 2. (a) Name all the bones which form the orbital cavity. (b) Which are common to both orbits? 3. What do you understand by the following : Hypopyon, Argyll-Robertson pupil, mydriasis, presbyopia, ptosis? 4. Where would you look for the cause of much of the ear trouble in children? Discuss briefly. 5. Describe and treat five pathological conditions of the ear. JURISPRUDENCE. i. Differentiate between antemortem and postmortem wounds. 2. What would guide you in determining whether a gun- shot wound was self-inflicted? 3. Describe briefly duties of coroner when finding of dead body is reported to him. 4. Whatdo you understand by abortion, infanticide, de- mentia, poison, syncope, catalepsy? 5. (a) Treat a case of opium poisoning, (b) Differenti- ate between poisoning from strychnine and arsenic. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Board of Medical Examiners of South Dakota. ANATOMY. 1. A typical cell is the ultimate element of structure; it enters into the formation of all tissues. It consists of a tiny mass of protoplasm, and contains a nucleus and. an attraction sphere, but as a rule no cell wall. Cells vary in shape and size (from about 1-3000 to 1-300 of an inch in diameter), and are characterized by power of. movement, 621 MEDICAL RECORD. assimilation, growth, excretion, and reproduction. Prop- erties of cells: (i) Irritability, or power of responding to a stimulus; (2) power of movement; (3) power of assimi- lation; (4) power of growth; (5) power of excretion, and (6) power of reproduction. Cells may be classified as: (1) Epithelial; (2) connective tissue; (3) muscle, and (4) nerve cells. 2. Cartilage is a form of connective tissue; it is firm and elastic; opaque, and of a bluish color. The varieties are: (1) Hyaline, in which the cells are relatively few and are imbedded in a quantity of ground substance. (2) White fibro cartilage, in which the ground substance contains bundles or layers of white fibers, between which are en- capsulated cells. (3) Yellow iibro cartilage, in which the ground substance contains a network of yellow, elastic fibers, and the cartilage cells are in the meshes of this net- work. 3. Mulberry mass is the more or less globular mass of cells, the result of repeated segmentation of the fertilized ovum. Primitive streak is a linear marking appearing at the end of the germinal disc, and indicating the first trace of the embryo. Ectoderm is the outer layer of the blasto- derm. From the mesoblastic layer are derived : The skele- ton, connective tissues, muscles and bones, heart, blood- vessels, lymphatics, and spleen; the urinary and generative organs. 4. See Cunningham's "Anatomy" (1909), page 1139; or Gray's "Anatomy" (1908), page 1427. 5. Psoas magnus. Origin: Transverse processes of lumbar vertebrae ; also from bodies of last thoracic and all lumbar vertebrae, with the intervertebral substance. Inser- tion: Lesser trochanter of femur. Serratus magnus. Origin: Eight upper ribs and aponeurosis over intercostal muscles. Insertion: Vertebral border of costal surface of scapula. Teres major. Origin: Inferior angle of scapula and lower one-third of axillary border of scapula. Inser- tion: Inner edge of bicipital groove of humerus. Deltoid. Origin: From the outer third of anterior border and upper surface of the clavicle, from the outer margin and upper surface of the acromion process, and from the lower edge of the spine of the scapula. Insertion: Into- the deltoid impression on the middle of the outer side of the shaft of the humerus. 6. Arteries which supply the rectum: (1) Superior hemorrhoidal (from inferior mesenteric) \ (2) middle hemorrhoidal (from internal iliac), and (3) inferior hem- orrhoidal (from internal pudic). The veins correspond to the arteries, and commence in a plexus around the anus from this plexus vessels ascend between the muscular and mucous coat. 622 iMEDICAL RECORD 7. See Cunningham's "Anatomy" (1909), page 923; or Gray's "Anatomy" (1908), page 810. 8. In intracapsular fracture of the femur: (1) The lower fragment is drawn upward by the glutei, the rectus, the biceps, semimembranosus, and semitendinosus ; (2) the limb is everted; this is due to the force of gravity (and external rotators). 9. Ligaments of the knee-joint: Anterior, or Ligamen- tum patellae; posterior; internal lateral; two external lat- erals; capsular; external crucial; internal crucial; trans- verse; coronary; Ligamentum mucosum, and Ligamenta alaria. For a description of these ligaments, see Cunning- ham's "Anatomy" (1909), page 298; or Gray's "Anatomy" (1908), page 337. 10. A lobule of the liver is about 1-20 to 1-12 inch in diameter. It has a darkish red center and a lighter circum- ference. The center is occupied by an intralobular vein which collects the blood from the capillaries of the lobule, and flows into the sublobular vein, which latter opens into the hepatic vein. Around the lobules are the interlobular veins; these are branches of the portal system; capillaries passing from the circumference to the center of the lobule connect the interlobular and intralobular veins. Between the network of capillaries in the lobule the hepatic cells are packed. PHYSIOLOGY. 1. (a) Fibrin is found in the blood and lymph; (b) mucin, in saliva and synovial fluid; (c) leucin, in the pan- creas and spleen; (d)chondrin, in bone and cartilage. 2. The impulse causing ordinary muscular contractions originates in the centers of the brain or spinal cord, and then travels by the nerves going to the particular muscles. As such nerve enters a muscle it breaks up into a number of branches, which are distributed to all parts of the muscle. The terminal ends of the nerve are scattered in great numbers throughout the muscle, and the impulse carried by the nerve is transmitted by the end plates to the various muscle fibers. Sometimes the muscular con- traction may be reflex. (See below, Question 8.) 3. Stammering is defined as faltering and interrupted speech, especially hesitancy and interruption in speech from difficulty in enunciating certain letters properly. Cause: According to Kirkes, "stammering depends on a want of harmony between the action of the muscles (chiefly abdom- inal) which expel air through the larynx and that of the muscles which guard the orifice (rima glottidis) by which it escapes, and of those (of tongue, palate, etc.) which modulate the sound to the form of speech. Over either of these groups of muscles, by itself, a stammerer may have 623 MEDICAL RECORD. as much power as other people, but he cannot harmoniously arrange their conjoint actions." 4. The blood is fluid, somewhat viscid, red, specific grav- ity from 1055 to 1062, alkaline reaction, saltish taste, char- acteristic odor, variable temperature (average about ioo° F.). The constituents are plasma and corpuscles. The plasma consists of water and solids (proteids, extractives, and inorganic salts). The red corpuscles consist of water and solids (hemoglobin, proteins, fat, and inorganic salts). The white corpuscles consist of water and solids (protein, leuconuclein, lecithin, histon,.etc). The red cells are bicon- cave discs, about 1-3200 of an inch in diameter; they are nonnucleated, and there are about 4,500,000 or 5,000,000 of them in each cubic millimeter of blood. They are elastic and soft, and their shape is changed by pressure, but is promptly regained on the removal of the pressure. Their color is yellowish. They contain hemoglobin. They carry oxygen from the lungs to the tissues. The white blood cells are spheroidal masses, varying in size, having no cell wall, and containing one or more nuclei ; there are about 7,000 to 10,000 of them in each cubic millimeter of blood. They differ much in appearance, and are divided into (1) small mononuclear leucocytes, or lymphocytes ; (2) large mononuclear; (3) transitional; (4) polynuclear, or poly- morphonuclear, or neutrophile, and (5) eosinophile. They are all more or less granular, particularly the last two varieties named. They are probably formed in the spleen, lymphatic glands, and lymphoid tissues. Their fate is un- certain; it has been asserted that they are converted into red blood cells; they play a part in the formation of fibrin ferment; they are sometimes converted into pus cells. Their functions are (1) to serve as a protection to the body from the incursions of pathogenic microorganisms ; (2) they take some part in the process of the coagulation of the blood; (3) they aid in the absorption of fats and peptones from the intestine, and (4) they help to maintain the proper proteid content of the blood plasma. There are also platelets, which are very small, colorless, irregular shaped bodies; they are about one-fourth the diameter of a red corpuscle. Their function is not deter- mined ; it is possible that they take some part in the coagu- lation of the blood. In number they vary from about 200,000 to more than 500,000 in each cubic millimeter of blood. Plasma conveys nutriment to the tissue ; it holds in solution the carbon dioxide and water which it receives from the tissues, and takes them to be eliminated by the lungs, kidneys, and skin ; it also holds in solution urea and other nitrogenous substances that are taken to and excreted by the liver or kidneys. Arterial blood is bright red in color, contains more oxygen, less carbon dioxide, more 624 MEDICAL RECORD. water, and is slightly warmer; venous blood is purple in color, contains less oxygen, more carbon dioxide, less water, and is slightly cooler (except in the hepatic vein). 5. The functions of the liver are: (1) The secretion of bile; (2) the formation of glycogen; (3) the formation of urea and uric acid; (4) the manufacture of heat, and (5) the conversion of poisonous and harmful into inert material. 6. The rate of circulation in the arteries is about twelve inches in one second ; in the capillaries, about one or two inches a minute ; in the veins, about nine inches in a second. 7. Lymph is an albuminous, straw-colored fluid, contain- ing lymph corpuscles ; it is alkaline in reaction, has a spe- cific gravity of about 1015, has a salty taste, and no odor; it clots in the same manner as blood. Chyle is much the same, but contains fat; it is opaque and whitish. 8. Reflex actions are involuntary or unconscious move- ments, due to suitable stimuli. They depend upon the in- tegrity of the reflex arc, which is a complex made up of : (1) A surface capable of receiving an impression; (2) an afferent nerve; (3) a nerve cell capable of receiving and also of sending out impulses ; (4) an efferent nerve, and (5) a surface capable of responding in some way to the impulse conveyed by the efferent nerve. Reflexes are classi- fied as: (1) Superficial, (2) deep, and (3) visceral. Ex- ample: The patellar reflex consists of a contraction of the extensor muscles of the leg and a movement of the foot forward when the Ligamentum patellae is struck; the quad- riceps extensor must first be slightly stretched by putting one knee over the other. Its integrity depends upon a healthy condition of the entire reflex arc, consisting of tendon, afferent or sensory nerve, posterior roots, and ante- rior horn of the spinal cord, the efferent or motor nerve, and the muscle itself. 9. Human milk contains less proteids and fats and salts then cow's milk, and at the same time contains more sugar and more water. 10. Secretion means the process by which some of the constituents of the blood are separated from the blood stream (by the activities of the capillary endothelium, as the blood passes through the capillaries) and elaborated into other material. The products of secretion vary with the gland or membrane where it occurs. Thus : Saliva, tears, milk, bile, gastric juice, synovial fluid, serous fluid, pancreatic juice. CHEMISTRY. i. (a) Chemistry is that' branch of science which treats of the composition of bodies, their changes in composition, and the laws governing such changes, (b) Chemical affln- 62$ MEDICAL RECORD. ity is the force that binds atoms together to form mole- cules. 2. (a) Crystalline substances are solid bodies of a defi- nite geometrical shape, which conduct heat more readily in some directions than in others; when broken, separate in certain directions (called planes of cleavage) more readily than in others, and modify the course of light according to the direction in which the rays pass through it. {^Condi- tions under which matter will crystallize : There must be the possibility of the freest motion of the smallest parti- cles of the matter to be crystallized; hence the substances must be heated (melted) or dissolved in some suitable agent, or must be in the gaseous state. Some substances will never crystallize. 3. An amorphous substance is one that is not crystalline. A polymorphous substance is one that can crystallize in more than one system. Isomorphous substances are differ- ent substances which will crystallize in forms identical with each other. 4. (a) Quantivalence is the combining power of an ele- ment or radicle expressed in terms of the number of hydro- gen atoms it can unite with or replace. (&) Univalent: Hydrogen, chlorin, bromin, iodin, sodium, potassium, silver. Bivalent: Oxygen, sulphur, calcium, barium, lead, mercury. Trivalent: Nitrogen, phosphorus, arsenic, anti- mony, boron, bismuth. Quadrivalent: Carbon, silicon, tin, platinum. 5. If a certain volume of hydrogen weigh twenty grains, a like volume of oxygen will weigh sixteen times as much, namely, three hundred and twenty grains. 6. INSPIRED AIR EXPIRED AIR Oxvsren 21 per cent. 79 per cent. 0.04 per cent. Rare. Variable. Variable. Varies. Always present. Always present. 16.6 per cent. Nitrogen 79 per cent. Carbon dioxide. . . Other gases Watery vapor Temperature Volume 4.4 per cent. Often present. Saturated. That of body. Diminished. Bacteria Dust None. None. In inspiration, oxygen is taken in; it then combines with the hemoglobin of the blood, and is carried round to the tissues. The carbon dioxide is given off in the tissues to the plasma of the blood, by which it is carried round to the lungs and given off in expiration. 7. Bismuth subnitrate has the chemical composition BiONOs. It is a heavy, white powder, odorless, almost 626 MEDICAL RECORD. tasteless, slightly acid in reaction ; it is decomposed by pure water. They blacken the stools by forming bismuth sul- phide with the hydrogen sulphide of the intestine. Its most dangerous impurity is arsenic. This may be detected by the Reinisch test, which is conducted as follows : Make a solution of the bismuth subnitrate, then add a little pure HC1; suspend in the fluid a small strip of bright copper foil, and boil. If a deposit forms on the copper, remove the copper, wash it with pure water, dry on filter paper, but be careful not to rub off the deposit. Coil up the copper and put it into a clean, dry glass tube, open at both ends, and apply heat at the part where the copper is. If arsenic is present there will appear in the cold part of the tube a mirror, which will be found on microscopical examination to consist of octahedral crystals of arsenic trioxide. 8. (a) Phosphates and albumin, (b) Add a little nitric acid; this will dissolve the phosphates, but will not affect the albumin. 9. (a) Fermentation test: Three Smith's fermentation tubes are used, each containing a little compressed yeast, one filled with the liquid to be tested, the second with pure water, and the third with a dilute solution of glucose, and the three are put in a warm place over night. If gas col- lects in the first and third tubes, but not in the second, the liquid contains sugar ; if gas collects in the third only it does not; under any other circumstances the yeast is at fault. (b) Fehling's method for the quantitative estimation: The solution is made as follows: (1) Dissolve cupric sul- phate 51.98 gra., in water to 500.00 c.c. ; (2) dissolve Ro- chelle salt, 259.0 gm., in sodium hydroxide soln. sp. gr. 1.12 to 1000 c.c. When required for use, one volume of 1 is to be mixed with two volumes of 2. The copper contained in 10 c.c. of this mixture is precipitated completely, as cuprous oxide, by 0.05 gm. of glucose. "To determine the quantity of sugar, place 10 c.c. of the mixed soln. in a flask of about 250 c.c. capacity ; dilute with H 2 to about 30 c.c, and heat to boiling. On the other hand, the urine to be tested is diluted and thoroughly mixed with four volumes of H 2 if it be poor in sugar, or with nine volumes of H 2 if highly saccharine, and a burette filled with the mixture. When the Fehling soln. boils, add a few gtt. NH 4 HO and then 5 c.c. of the urine from the burette, boil again, and continue the alternate addition of diluted urine and boiling of the mixture until the blue color is quite faint. Now add the diluted urine in quantities of 1 c.c. at a time, boiling after each addition until the blue color just disappears. Have ready a small filter, and, having filtered through it a few gtt. of the hot mixture, acidulate the filtrate with acetic acid, and add to it 1 gtt. soln. of potassium ferrocyanide. 627 MEDICAL RECORD. If a brownish tinge be produced, add another y 2 c.c. of dil. urine to the flask, boil, and test with ferrocyanide as be- fore. Continue this proceeding until no brown tinge is produced. The burette reading, taken at this point, gives the number of c.c. of dilute urine containing 0.05 gm. glu- cose, and this divided by 5 or 10, according as the urine was diluted with 4 or 9 volumes of H 2 0, gives the nmber of c.c. of urine containing 0.05 gm. sugar. The number of c.c. urine passed in twenty-four hours divided by twenty times the number of c.c. containing 0.5 gm. glucose gives the elimination of glucose in twenty-four hours in grams. 10. The prescription is incompatible. The water will cause the fluid extract to throw down a precipitate. BACTERIOLOGY. 1. Ptomains are the putrefaction products of dead animal tissues or fluids. Toxins are the poisonous products of pathogenic bacteria. 2. Bacteria multiply by fission. A bacterium about to divide seems to be larger than normal, and if it is a coccus it becomes more ovoid; changes occur first in the nucleus, and the bacterium just falls in two. Cocci may divide in one, two, or three directions of space; bacilli divide trans- versely to their long axis, and spirilla divide transversely to their long diameter. 3. A sterile swab is rubbed over any visible membrane on the tonsils or throat, and is then immediately passed over the surface of the serum in a culture tube. The tube of culture, thus inoculated, is placed in an incubator at 37 C. for about twelve hours, when it is ready for examina- tion. A sterile platinum wire is inserted into the culture tube, and a number of colonies of a whitish color are removed by it and placed on a clean cover slip and smeared over its surface. The smear is allowed to dry, is passed two or three times through a flame to fix the bacteria, and is then covered for about five or six minutes with a Loef- fler's methylene-blue solution. The cover slip is then rinsed in clean water, dried, and mounted. The bacilli of diph- theria appear as short, thick rods with rounded ends ; irreg- ular forms are characteristic of this bacillus, and the stain- ing will appear pronounced in some parts of the bacilli and deficient in other parts. Methods of culture: The bacillus of diphtheria grows upon all the ordinary culture media, and can be readily obtained in pure culture. Loeffler's blood serum, particularly with the addition of a little glucose, is an admirable medium for the rapid growth of this bacillus. The medium should be alkaline and not less than 20 C. Method of staining: It stains with any aqueous solution of an anilin dye, and quite characteristically with Loeffler's alkaline methylene blue. Neisser's stain is also recognized. The bacilli also stain well by Gram's method. 628 MEDICAL RECORD 4. Three conditions essential to bacterial growth: Rest, moisture, neutral or feebly alkaline reaction. The most common microorganisms of suppuration are: Staphylo- coccus pyogenes aureus, Staphylococcus pyogenes albus, Staphylococcus pyogenes citreus, Streptococcus pyogenes. 5. The supposed microorganism of cerebrospinal menin- gitis is the Diplococcus intra cellular is meningitidis. Lum- bar puncture is performed, and about 10 c.c. of the cerebro- spinal fluid is withdrawn. About 1 c.c. of this is dropped into sterile test tubes. It is cultivated on agar plates or Loeffler's blood serum mixture, and recoognized with the microscope. PATHOLOGY. 1. Active hyperemia means that there is an excess of arterial blood in a part, and is generally accompanied by an increase in the rate of blood flow. In passive congestion there is still an excess of blood, but it is in the veins and capillaries, and the blood flow is retarded. 2. In arteriosclerosis it is mainly the innner coat which is affected ; this becomes thickened by layers of fibrous tissue owing to the proliferation of the subendothelial con- nective tissue cells. This thickening is not uniform. The elastic layer becomes granular, and it may be partially de- stroyed. Where high arterial tension exists the media is affected, and the muscle fibers become hypertrophied ; some- times degeneration occurs here. The vessels increase in length and thickness, becoming tortuous ; they also feel resistant and cord-like. 3. Osteomyelitis is inflammation of bone and marrow. 4. As the sputum is generally examined for tubercle bacilli, that will be described. The sputum must be recent, free from particles of food or other foreign matter ; select a cheesy-looking nodule and smear it on a slide, making the smear as thin as possible. Then cover it with some carbol- fuchsin and let it steam over a small flame for about two minutes, care being taken that it does not boil. Wash it thoroughly in water and then decolorize by immersing it in a solution of any dilute mineral acid for about a minute. Then make a contrast stain with solution of Loeffler's methylene blue for about a minute ; wash it again and ex- amine with oil immersion lens. The tubercle bacilli will appear as thin red rods, while all other bacteria will appear blue. 5. "Ehrlich's side chain theory of immunity is based on the idea that the toxin destroys a cell by entering into chemical union with it. The molecule of toxin contains at least two groups of atoms, a toxophore group, in which the poisonous principle resides, and a haptophore group, which brings the toxophore group into touch with the cell and through which chemical combination takes place. Similarly, 629 MEDICAL RECORD. the cell contains a haptophore group, but the toxophore group of the toxin can only unite with it and destroy it when its haptophore companion has affinity with that of the cell. If that affinity does not exist, the two haptophore groups do not unite, the toxophore group does not come into contact with the cell, and the animal is immune. Such is natural immunity. If there is affinity and the cell can throw off a haptophore group (antitoxin), which in its detached condition unites with the haptophore group of the toxin, the toxophore group has then nothing with which it can unite and the animal is immunized. When the indi- vidual has to contend with a bacterium as well as its toxin, the same principle obtains. Immunity is established by the production of a double haptophore group, one for the bacterium, the other for its toxin." — (Stenhouse's Path- ology.) 6. Healing by second intention or granulation occurs when the edges of the wound have not been brought to- gether. "Exudation of plasma and leucocytes occurs, fol- lowed by fibroblasts and budding from the capillaries, thus forming granulation tissue. The dead tissues or sloughs are separated, and a red area of granulation is then ex- posed. The deeper layer of granulation tissue is con- verted into fibrocicatricial tissue, which contracts, and so the wound gradually lessens in size. In the meantime epi- thelium spreads in from the edge over the surface, and so the scar is completed. ,, — {Aids to Surgery.) 7. Atrophic cirrhosis of the liver is caused by: Poisons, alcohol, fatty acids, specific fevers, microorganisms ab- sorbed from the intestine, and syphilis. Symptoms: Dys- pepsia, furred tongue, high colored urine, hematemesis, ascites. Pathology: The liver is shrunken and indurated, rough, and of a pale or yellow color ; a growth of new con- nective tissue is disposed in broad bands which run in various directions, and by their contraction divide the liver into numerous irregular lobes. Many acini may be affected at one time. The capsule may be thickened, or adherent to the diaphragm. Jaundice is slight, and comes on late; ascites is pronounced and may occur early. 8. An embolus is a body which plugs up a blood-vessel, and is carried there from some other part of the circula- tion. A thrombus is a clot in a blood-vessel during life. 9. In urticaria the wheal is produced by some disturb- ance to the vasomotor nervous apparatus. It is circum- scribed, and consists of an edema of the epidermis. There may be dilatation of the cutaneous vessels, with exudation of serum and white blood cells. This exudation may cause a pressure anemia, which produces the white appearance of the skin; around this is a red areola, due to the engage- ment of the peripheral vessels. 630 MEDICAL RECORD. io. (i) Normoblast, same size as normal red blood cell; (2) microblast, which is smaller; (3) megaloblast, which is larger than the normal red cell. PRACTICE AND THERAPEUTICS. i. (1) Simple, and (2) cholera infantum. 2. Varicella is chickenpox; variola is smallpox. (1) Very young children are attacked with varicella, whereas variola usually shows itself in adults. (2) Vacci- nated children readily take varicella; not so variola, even in the modified form. (3) Children who have had varicella may contract variola, even soon afterward; or the two dis- eases may co-exist. (4) Varicella is not inoculable, where- as variola is notoriously so. (5) The eruption of varicella appears in twenty-four hours ; that of variola not till the third day. (6) The febrile symptoms continue after the eruption appears in varicella; those of variola subside. (7) In varicella the spots come out in successive crops ; this is never seen in variola. (8) The spots in varicella are uni- locular, and collapse on being punctured ; the spots in vari- ola are multilocular, and do not collapse on being punc- tured. (9) In varicella the eruption is very irregular, and appears over the body generally; in variola it appears in groups of threes and fives, and is always seen on the limbs. (10) The papule in varicella is soft, and disappears on stretching the skin; in variola it is hard and snotty, and does not disappear on stretching the skin. 3. See French's "Practice of Medicine" (1907), pages 508 and 510; or Osier's "Practice of Medicine ,, (1909), pages 724 and 726. Idiopathic anemia and progressive pernicious anemia are one and the same disease. 4. See French's "Practice of Medicine" (1907), page 1117; or Osier's "Practice of Medicine" (1909), page 1045. 5. Neurosis of the bladder is the name which includes a number of conditions, such as : Hyperesthesia, neuralgia, atony, paralysis, and hysteria of the bladder; also incon- tinence of urine. Cystitis is inflammation of the blad- der. See Rose and Carters' "Surgery" (1908), pages 1192, 1201 ; or De Costa's "Surgery" (1908), pages 1130, 1135. 6. Ascites. Symptoms, etc.: Generally of gradual onset ; abdominal distention, sense of weight and fulness; dyspnea; gastrointestinal disturbances; linese albicantes, presence of fluid may be detected by palpation, percussion or aspira- tion. If due to heart or lung disease, ascites will occur elsewhere, and the legs are generally affected first; in hepatic disorders the abdominal distention is marked and appears early; in renal disease, the abdominal fluid is generally small in amount. Treatment: Tapping, drainage, incision, and administration of cathartics have all been recommended. Ovarian tumor, pregnancy, distended blad- 631 MEDICAL RECORD der, pancreatic cyst, and echinococcus cyst may be mistaken for it. 7. Bronchopneumonia is an acute inflammation of the terminal bronchi, air cells, and interstitial tissue of isolated lobules of the lungs, or groups of globules. Lobar pneu- monia is an acute infectious disease of the lungs, with in- flammation and consolidation of one or more lobes of the lung. LOBAR PNEUMONIA Generally a primary disease. Age has little influence. Sudden onset. Fever is high and regular. Ends by crisis between sixth and tenth day. Generally only one lung af- fected. The physical signs are dis- tinct, and there is a large area of consolidation. Sputum is rusty. BRONCHOPNEUMONIA Generally secondary (to bronchitis or an infectious disease). Generally found in very young or very old. Gradual onset. Fever is not so high, and is irregular. Ends by lysis, at no partic- ular date. Generally both lungs af- fected. Physical signs indistinct, and the evidences of consolida- tion are indefinite. Sputum is rather streaked with blood. 8. (a) By mouth, inhalation, skin, rectum, vagina, hypodermic, and in veins, (b) Chloral hydrate is used as an antiseptic, counterirritant, hypnotic, and to alleviate whooping cough, tetanus, and strychnine poisoning. It is contraindicated in diseases of heart, lungs, stomach, and bowels. 9- STRANGULATION. INTUSSUSCEPTION. TWISTS (volvulus). Subjective Subjective Subjective Symptoms. Symptoms. Symptoms. 1. Generally oc- 1. Most frequent 1. Most frequent curs after age in childhood. after age of 30. of 20. 2. Pain localized, 2. Constant .tenes- 2. Pain diffuse. rapid collapse. mus. 3. Pain intense, 3. Pain develops 3. Pain paroxys- paroxysmal in suddenly and mal; recurs character. is continuous. less often than in strangula- tion. 632 MEDICAL RECORD. STRANGULATION. 4. Constipation complete. Objective Symptoms. 1. Tern peratu re often subnor- mal. 2. Pulse very weak. 3. Stercoraceous vomiting comes on early. 4. Location in small intestine. INTUSSUSCEPTION. 4. Frequent diar- rhea,passageof bloody mucus. Objective Symp- toms. 1. Temperature normal or sub- normal. 2. S a m e as in strangulation. 3. Same as in strangulation. 4. Localization in small -i ntes- tine ; bowel frequently pro- trudes at rec- tum. TWISTS (volvulus) \. Constipation complete. Objective Symp- toms. 1. Temperature slightly e 1 e - vated. 2, Same as in strangulation. Same as in strangulation. 3- Location, small intestine ; ab- domen often protrudes, in certain areas, giving dull- ness on per- cussion. 10. Digitalis is indicated in diseases of the heart: (1) when the heart action is rapid and feeble, with low arterial tension; (2) in mitral lesions when compensation has be- gun to fail; (3) in nonvalvular cardiac affections; (4) in irritable heart, due to nerve exhaustion. Digitalis is con- traindicated in diseases of the heart: (1) in aortic lesions when uncombined with mitral lesions; (2) when the heart action is strong, and arterial tension high. Digitalis is also a diuretic; and it is also used in some forms of nephritis, exophthalmic goiter, pneumonia, chronic bronchitis, etc. In poisoning there are: Nausea and vomiting, sometimes colic and diarrhea, slow pulse, dyspnea, cold extremities, headache, vertigo, somnolence, and syncope : death may occur. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), page 83; or Hirst's "Obstetrics" (19C9), page 61. 2. See Williams' "Obstetrics" (1909), pages 180 and 190; or Hirst's "Obstetrics" (1909), pages 189 and 204. 3. Indications for the use of forceps are: (1) Forces at fault: Inertia uteri in the presence of conditions likely to jeopardize the interests of mother or child, (a) Impending exhaustion; (b) arrest of head, from feeble pains. (2) Passages at fault: Moderate narrowing, 354 to s 3 A inches, 633 MEDICAL RECORD. true conjugate; moderate obstruction in the soft parts. (3) Passenger at fault: A. Dystocia due to (a) occipito-poste- rior; (b) mentoanterior face; (c) breech arrested in cav- ity. B. Evidence of fetal exhaustion (pulse above 160 or below 100 per minute). (4) Accidental complications: Hemorrhage; prolapse funis; eclampsia. All acute or chronic diseases or complications in which immediate de- livery is required in the interest of mother or child, or both. Contraindications: Mechanical obstruction in the parturient canal; .incomplete dilatation of the os; non- rupture of membranes; non-engagement of the presenting part; the fetal head being too large or too small; distended bladder or rectum. 4. See Williams' "Obstetrics" (1909), pages 289 and 805; or Hirst's "Obstetrics" (1909), page 583. 5. See Williams' "Obstetrics" (1909), pages 865 and 898; or Hirst's "Obstetrics" (1909), page 761. 6. See Williams' "Obstetrics" (1909), pages 316, 317, and 325; or Hirst's "Obstetrics" (1909), pages 333 and 607. 7. Position is L.Scap.A. The head of the fetus is in the left iliac fossa, back anterior, extremities, on right side in upper part of abdomen. Do not replace the arm ; version : if impaction is present, decapitation or cesarean section. 8. See Williams' "Obstetrics" (1909), page 226; or Hirst's "Obstetrics" (1909), page 320. 9. See Williams' "Obstetrics" (1909), page 914; or Hirst's "Obstetrics" (1909), page 708. 10. See Williams' "Obstetrics" (1909), page 340; or Hirst's "Obstetrics" (1909), page 364. DISEASES OF WOMEN. 1. See Gray's "Anatomy" (1908), pages 1440 and 1495. 2. It may become polypoid, and project from the os uteri; it should then be removed, and if possible the pedicle should be first twisted. If large, the fibroid may have to be removed piecemeal, and the hemorrhage can be stopped by pressure and packing, or by a clamp forceps. If the tumor is entirely within the uterine cavity, the cervix must be dilated and the fibroid then removed, care being taken not to perforate the wall of the uterus. The patient should be in the lithotomy position, and proper antiseptic and aseptic precautions must be observed. 3. Symptoms: Pain^ or a feeling of weight and fullness in the pelvis, constipation or discomfort during defecation, tubes and ovaries are dragged upon and the latter may be prolapsed, dyspareunia, dysmenorrhea, possibly sterility, metrorrhagia, leucorrhea, and reflex disturbances. Treat- ment: (a) Replace the uterus with fingers, or sound; keep it in place with pessary or tampons (adhesions if present must have been broken up) ; (b) shorten round ligament, 634 iMEDICAL RECORD. or perform hysteropexy. See Rose and Carless' "Surgery'' (1908), page 1278. 4. Etiology: Relaxation of vaginal walls; generally due to partruition, and torn perineum; lax uterine supports; subinvolution of uterus; prolapse of uterus. Treatment: Mend perineum, replace uterus, shorten round ligament if latter are too lax, colponhaphy. SURGERY. 1. The knee is the joint most frequently affected. See Rose and Carless' "Surgery" (1908), page 642; or Da Costa's "Surgery" (1908), page 546. 2. See Rose and Carless' "Surgery" (1908), page 76; or Da Costa's "Surgery" (1908), page 203. It often accom- panies a wound or abrasion. 3. See Rose and Carless' "Surgery" (1908), page 350; or Da Costa's "Surgery" (1908), page 351. 4. See Rose and Carless' "Surgery" (1908), page 448; or Da Costa's "Surgery" (1908), page 472. 5. See Rose and Carless' "Surgery" (1908), page 461; or Da Costa's "Surgery" (1908), page 664. 6. See Rose and Carless' "Surgery" (1908), page 1081 ; or Da Costa's "Surgery" (1908), page 978. 7. See Rose and Carless' "Surgery" (1908), page 1159; or Da Costa's "Surgery" (1908), page 1101. 8. See Rose and Carless' "Surgery" (1908), page 1132; or Da Costa's "Surgery" (1908), page 1008. 9. The subcoracoid is the most common. See Rose and Carless' "Surgery" (1908), page 622; or Da Costa's "Sur- gery" (1908), page 590. 10. See Rose and Carless' "Surgery" (1908), page 1267; or Da Costa's "Surgery" (1908), page 1202. (a) EYE AND EAR. ACUTE IRITIS. 1. Pupil: small, sluggish, irreg- ular after at- ropine. 2. Iris: swollen, dirty, lymph on surface. 3. Anterior cham- ber : normal (or deeper, with turbid contents). ACUTE CONJUNC- TIVITIS. Normal. Clean and bright. Normal. ACUTE GLAUCOMA. Dilated, oval, fixed. Swollen and dis- colored. Shallow. 635 MEDICAL RECORD ACUTE IRITIS. ACUTE CONJUNC- TIVITIS. ACUTE GLAUCOMA. 4- Cornea : clear Clear. Steamy ; anesthet- (or with de- ic. posits on back). 5. Ciliary region : injected. Not injected. Injected. 6. Conjunctiva :' Red, opaque, per- Great congestion, usually some haps swollen. perhaps chem- injection. osis. 7- Discharge : tears only. Muco-pus. Tears only. 8. Palpation : ten- Tension normal, Tension -f- 2 to 3, sion normal not tender. very tender. (occasionally -j- i) ; tender in ciliary re- gion. 9. Pain : over fore- Sand or grit in Intense neuralgia head and nose, eyes. in and about worse at night. eyes, nausea, vomiting. 10 . Vision : cloud- Scarcely affected. Rapidly lost; field ed. extremely lim- ited ; "rainbow rings" seen. II . Disc: if seen, Normal. If seen, cupped, normal. and arterial pulsation. (b) (1) Trachoma is a chronic disease of the conjunc- tiva, marked by granulation of the eyelids, later by atrophy, and cicatricial contraction. Treatment: Astringents, ex- pression, or excision. (2) Glaucoma a condition charac- terized by increased ocular tension, dilatation of pupil, dim- inution of sight, and atrophy of the optic disc. Treatment: Iridectomy. (3) Ophthalmia neonatorum is an infectious, purulent inflammation of the conjunctiva in the newborn, due to the gonococcus or other pyogenic germ ; produced by contact of the eye with the vaginal secretion of the mother during labor, or infected fingers, or instruments, etc. Treatment: Wash the eyes carefully every half hour with a saturated solution of boric acid; pus must not be allowed to accumulate. Two drops of a 2 per cent, solu- tion of nitrate of silver must also be dropped on to the cornea every night and morning. The eyes must be cov- ered with a light, cold, wet compress. The patient must be isolated, and all cloths and compresses used must be burnt. 636 MEDICAL RECORD. (4) and (5) Iritis and Conjunctivitis: See above, Q. 1 (a). Treatment of iritis is causal, abstraction of blood from tem- ples, atropine, diaphoresis, shielding the eye from light. Treatment of conjunctivitis: If there is much swelling and scanty secretion, compresses (iced or hot), instillation of boric acid or bichloride solution; in profuse secretion with relaxed conjunctiva, silver nitrate solution ; in phlyctenular conjunctivitis, calomel or ointment of yellow oxide of mer- cury; or alum or tannic acid solutions. 2. (a) Frontal, ethmoid, sphenoid, lachrymal, malar, pal- ate, superior maxillary, (b) Frontal ethmoid, sphenoid. 3. Hypopyon is a collection of pus in the bottom of the anterior chamber of the eye. Argyll-Robertson pupil is a condition in which the pupil accommodates for distance but not for light. Mydriasis is dilatation of .the pupil. Presbyopia is loss of accommodative power of the eye, oc- curring normally in advanced life. Ptosis is drooping of the upper eyelid. 4. In the nasopharynx. Adenoids may be the cause; they may cause deafness, they may occlude the Eustachian tube, or excite a catarrhal inflammation which may spread through the tube to the ear, or infection may spread by the same route, causing otitis or other troubles. 5. (1) Impacted cerumen. Disintegrate it with hydrogen peroxide, which is left in the ear a few minutes, and fol- lowed by an irrigation of warm water. (2) Furuncle. Hot applications; cleansing with hydrogen peroxide; mor- phine, and calcium sulphide internally; incision. (3) For- eign bodies: First see that there is a foreign body. In- sects may be removed by warm water or chloroform oil. Careful syringing may remove other bodies. (4) Rupture of membrane from explosion of guns, or sudden condensa- tion of air : Rest, cleanse the meatus, gentle irrigation with warm bichloride solution (1:10.000). (5) Stricture of Eustachian tube: Application of bougie, and inflation with superheated air may promote absorption of the new tissue. JURISPRUDENCE. 1. Ante-mortem wounds generally show hemorrhage, co- agulated blood, eversion of the edges and retraction of the sides; pus, gangrene, or beginning cicatrization also in- dicate that the wound was inflicted during life. Post- mortem wounds, the reverse of all this. 2. The location of the wound, the presence or absence of weapons, character of wound, the burning or charring of skin or clothing. 3. If cause of death is unknown or suspicious (possi- bility of either homicide, or suicide, or other crime), it is the duty to discover the cause of death (it is no part of his business to discover the individual who caused it). He 697 MEDICAL RECORD. calls a jury to view the body and establish its identity; an inquest is held, witnesses are examined, possibly an autopsy is performed, and the jury renders a verdict. 4. Abortion is expulsion of the fetus before the term of gestation is complete. Infanticide is destruction of life of a newborn child. Dementia is a condition of mental en- feeblement, gradually progressing to mental decay. Poison is a substance which on being in solution in the blood will cause death or serious bodily harm. Syncope is suspended animation, due to sudden failure of the action of the heart. Catalepsy is a condition in which there is abolition of sensation and motion, with rigidity of muscles and slow pulse. 5. For opium poisoning: Wash into the stomach with a dilute solution of potassium permanganate, leaving about 500 c.c. in the stomach. Maintain respiration. Keep the patient moving. Strong coffee may be given. The urine should be drawn off by catheter. In poisoning by strych- nine: Sense of suffocation, twitchings of muscles, followed by tetanic convulsions and opisthonotos. Mental faculties unaffected, face congested and anxious; eyes staring, lips livid; much thirst. In poisoning by arsenic: Faintness, nausea, incessant vomiting, epigastric pain, headache, diar- rhea, tightness and heat of throat and fauces, thirst, catch- ing in the breath, restlessness, debility, cramp in the legs, and convulsive twitchings. The skin becomes cold and clammy. In some cases the symptoms are those of col- lapse, with but little pain, vomiting, or diarrhea. STATE BOARD EXAMINATION QUESTIONS. Tennessee State Board of Medical Examiners, materia medica. 1. Name two emetics, antipyretics (other than the coal- tar derivatives), antithelmintics, emmenagogues, diuretics, arterial sedatives, giving the dose of each, and the indica- tions for the use of each. 2. What are antiseptics (internal)? Name two. Give the dose of each and the best mode of administering them. 3. What preparation of veratrum viride would you use? In what pathological lesions and in what dose would you administer? 4. Name one alkaloid each of cinchona, belladonna, jaborandi, hyoscyamus, opium, and hydrastis. Give the dose of each and indications for use. 5. What is the physiological action of podophyllin? 6. How would you prepare a normal salt solution and under what conditions, would you use it? fe* „ •-*** 638 MEDICAL RECORD. 7. How is Fowler's solution prepared? & How is the tincture of iodine prepared? ANATOMY. 1. Name the muscles of the face and of the forearm. 2. Name the bones of the face and of the wrist. 3. Describe the external carotid artery, point of origin, and general course. 4. Describe the femoral artery. Give the point of origin and the important branches given off in its course. 5. Describe the diaphragm, its openings, the different organs in contact with or separated by it. 6. Describe the scrotum. 7. Name the largest muscle in the human body. Give origin and insertion. 8. Name the ligaments of the shoulder and elbow joints. CHEMISTRY. 1. (a) What is a urmometer? Of what does it con- sist? How graduated? (b) With what is urine com- pared? What is needed for an ordinary uranalysis? (c) If upon boiling urine you get a cloudy precipitate, how would you determine the nature of the precipitate? 2. (a) State methods of obtaining urinary sediments. (b) What is a centrifuge and how is it used? 3. Tell what you know r about oxygen. (Do not write more than one page.) 4. The stomach of a person supposed to have been poisoned with arsenic is brought to you; give ii detail your method of determining the presence or absence of that poison. 5. Give symptoms of strychnine poisoning and treat- ment of same. Differentiate its symptoms from those of other convulsive disorders. In case of death from strych- nine poisoning, why is it more difficult to prove than arsenical poisoning? 6. Heat, (a) Define and explain expansion, conduc- tion, and transmission, (b) What changes of state are produced by heat? (c) What is specific heat? (d) Give sources of heat. 7. State how, and the methods employed, and the source from which iodine is obtained. Common medicinal preparations used? How used? Doses and effects? 8. Define: (a) Static electricity, (b) Dynamic elec- tricity. State uses of each. Define terms volt, ohm, and ampere. SURGERY. i. Define the terms "Science" and "Art" of surgery. 639 MEDICAL RECORD. What is aseptic surgery? What is antiseptic surgery? Illustrate the two latter. 2. Describe a Pott's fracture. How caused? Give treatment for (a) simple, (b) compound, (c) comminuted Pott's fracture, (d) Describe a Colles' fracture and give treatment, (e) What is a common result of almost any fracture of a long bone? 3. Diagnose fecal impaction from invagination of a gut, and give method of treating the first. 4. What is osteomyelitis? Diagnose. Give causation and treatment. 5. Give diagnosis and treatment of cancer of the breast. 6. Define perineorraphy and trachelorraphy, and de- scribe the operation for each. 7. Describe in detail a curettement of the uterus. 8. Define (a) prostatectomy, (b) cystotomy, (c) nephrectomy, (d) nephrotomy, (e) lithotomy. Give in de- tail your method of enucleating an eye. PRACTICE. 1. Do you expect to have any puerperal fever in your practice? If you do, what will be the cause? De- fine puerperal fever, and give treatment. 2. Give symptoms, diagnosis, prognosis, and treatment of acute Bright's disease. Should you have uremic con- vulsions, what would be the cause, and how would you treat them? 3. What do you understand by gallstones? What is the technical name. Give diagnosis and treatment. 4. Give diagnosis and treatment of hereditary syphilis. 5. (a) Write a prescription for general debility, (b) one for an acute bronchial cough, (c) one for chronic constipation, (d) one for chronic diarrhea. 6. Define acute rheumatic fever. Give symptoms and treatment. What is the most frequent complication? 7. Give symptoms, diagnosis, prognosis and treatment of enterocolitis 8. Give symptoms, prognosis, and treatment of pur- pura hoemorrhagica. PATHOLOGY. 1. What is the meaning of active, and what of passive pathological changes? 2. What pathological changes take place in the kidneys during an attack of acute congestion? 3. What pathological changes take place in the kidneys during an attack of acute nephritis? 4. What pathological changes take place in the liver during an attack of acute catarrhal jaundice? 640 MEDICAL RECORD. 5. What pathological changes take place in catarrhal pneumonia ? 6. Give pathology of diphtheria. 7. What pathological changes take place in the spleen during an attack of malarial fever? 8. What is the pathology of erysipelas? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Tennessee State Board of Medical Examiners. materia medica. 1. Two emetics: Apomorphine hydrochloride, dose gr. 1-10 (hypodermically) ; Antimon> and potassium tartrate, dose gr. j. Two antipyretics : Quinine sulphate, dose gr. v. ; Tinc- ture of aconite, dose TTRx. Two anthelmintics: Oleoresina Aspidii, dose gr. xxx. ; Pelletierine taunate, dose gr. x. Two emmenagogues : Pill of aloes and iron, dose 2 pills; Black oxide of Manganese, dose gr. ij. Two diuretics : Infusion of Digitalis, dose 3ij ; Sparteine Sulphate, dose gr. ij. Two arterial sedatives: Tincture of Aconite, dose Tlftx; Tincture of Veratrum, dose ff#xv. 2. Internal antiseptics are drugs which, when swal- lowed or inhaled are supposed either to destroy or inhibit the growth of microorganisms. Two internal antiseptics: Creosote, dose TTJ^iij ; best ad- ministered in the form of an emulsion with codliver oil. Betanaphthol, dose gr. iv; best administered in keratin- coated pills if its action is desired on the intestines. 3. The preparation of veratrum viride to be used, is the tincture; dose TT^xv. Uses: As a circulatory depressant in pneumonia, in puerperal convulsions, tonsillitis, puerperal inflammations in general, mania, and as a rule very much as aconite. 4- One alkaloid. Cinchona Quinine Belladonna Atropine Jaborandi (Pilocarpine Hyoscyamus ] Hyoscine Dose. gr. iv (of the Sulphate) gr. 1/150 (of the Sulphate) gr. 1/5 (of the Hydrochloride) gr. 1/150 (of the Hydrobromide) Opium I Morphine |gr. 1/4 (of the Sulphate) Hydrastis jHydrastine gr. ss (of the Hydrochloride) 641 MEDICAL RECORD. 5. The physiological action of podophyllin: It is a gastrointestinal irritant; it has a drastic and cholagogue purgative action. 6. Normal salt solution is prepared by adding six drachms of sterilized sodium chloride to a liter of dis- tilled water in a sterilized glass flask. It is used to irrigate fresh wounds, to remove blood or foreign bodies, for cleansing mucous or serous sur- faces; it also is used for intravenous injection when the circulation is failing; by hypodermoclysis it is used also when the circulation is rapidly failing, and after profuse hemorrhage, in cases of shock, septicemia, and uremia. 7. Fowler's solution is prepared by boiling ten grams of arsenic trioxide, twenty grams of potassium bicarbonate, and thirty grams of compound tincture of lavender in suf- ficient distilled water to make one liter. 8. Tincture of iodine is prepared by dissolving seventy grams of iodine and fifty grams of potassium iodide in alcohol enough to make one liter. ANATOMY. 1. See Cunningham's "Anatomy" (1909), pages 397 and 336; or Gray's "Anatomy" (1908), pages 368, and 481 to 492. 2. See Cunningham's "Anatomy" (1909), pages 133 and 201; or Gray's "Anatomy" (1908), pages 71 and 195. 3. See Cunningham's "Anatomy" (1909), page 803; or Gray's "Anatomy" (1908), page 602. 4. See Cunningham's "Anatomy" (1909), page 858; or Gray's "Anatomy" (1908), page 698. 5. See Cunningham's "Anatomy" (1909), page 417; or Gray's "Anatomy" (1908), page 429. 6. See Cunningham's "Anatomy" (1909), page 1 169; or Gray's "Anatomy" (1908), page 1472. CHEMISTRY. 1. (a) A Urinometer is a form of hydrometer, used for determining the specific gravity of the urine. It consists of a cylinder and a spindle. The graduation on a urinometer is so constructed that the spindle sinks to the zero point when it is immersed in water at a given temperature. The denser the fluid into which the spindle is immersed, the higher it rises. The ordinary urinometer is graduated from o or 1,000 to 60 or 1,060. (b) Urine is compared (for purposes of specific grav- ity) with distilled water at a certain temperature which is indicated for each instrument (generally 6o° F.). For an ordinary urinalysis, there are needed: A gradu- ated cylinder in which to measure the quantity of urine; 642 MEDICAL RECORD. litmus paper ; a "color scale" ; urinometer ; test-tubes, test- tube holder, test-tube stand; ureometer ; albuminimeter ; burette; pipettes; glass funnel; beakers; filter papers ; al- cohol lamp; centrifuge; slides and cover slips; stains; microscope ; nitric acid ; Fehling's solution ; hypobromite solution, for ureometer ; acetic acid ; sodium hydroxide solution, potassium hydroxide solution. (c) The cloudy precipitate may be due to urates, phos- phates, or albumin. If it is due to phosphates, it will clear upon the addition of a few drops of nitric acid; if it is due to urates, it will disappear on being heated. 2. (a) Urinary sediments may be obtained (i) by al- lowing the urine to stand; (2) by centrifuging. (b) A centrifuge is an apparatus by means of which the solids in a fluid are separated by centrifugal force. 3. Oxygen is the most abundant of the elements, and is an essential element in the air and in water; it composes more than half of the earth's surface. It is a colorless, odorless, tasteless gas, necessary to respiration (and there- fore to life) ; it is combustible^ and a supporter of com- bustion. It combines readily with all the elements except fluorine. It has a valance of two, atomic weight 16, and molecular weight of 32. It is prepared by heating potas- sium chlorate: 2KCIO3 + heat = 2KCI + 3O2 4. "The stomach should first be carefully examined as to its pathological condition, and also for the presence of solid particles of the poison. It should then be cut up into small fragments with scissors known to be perfectly clean, and, together with its contents, placed in a clean porcelain evaporating dish ; distilled water added in suffi- cient quantity, together with about one-sixth the bulk of pure hydrochloric acid, and heated gently for about an hour, when most of the solid portions will have become disintegrated. After cooling, the mixture is thrown upon a muslin strainer and the solid matters washed several times with pure water and squeezed. The strainer and contents should be preserved for subsequent examination. The filtrate should be concentrated by evaporation over a water-bath and then filtered through paper." (Reese.) After this, the Reinsch test can be applied, as follows: To the suspected fluid add a little pure HC1; suspend in the fluid a small strip of bright copper foil, and boil. If a deposit forms on the copper, remove the copper, wash it with pure water, dry on filter paper, but be careful not to rub off the deposit. Coil up the copper, and put it into a clean dry glass tube, open at both ends, and apply heat at the part where the copper is. If arsenic is present there will appear in the cold part of the tube a mirror, which 643 MEDICAL RECORD. will be found on microscopical examination to consist of octahedral crystals of arsenic trioxide. 5. The symptoms of strychnine poisoning are as fol- lows : " Strychnine produces a sense of suffocation, thirst, tetanic spasms, usually opisthotonos, sometimes emprostho- tonos, occasionally vomiting, contraction of the pupils dur- ing the spasms, and death, either by asphyxia during a paroxysm, or by exhaustion during a remission. The symptoms appear in from a few minutes to an hour after taking the poison, usually in less than twenty minutes ; and death in from five minutes to six hours, usually within two hours. Treatment : ''The convulsions are to be arrested or miti- gated by bringing the patient under the influence of chloral or chloroform as rapidly as possible; the stomach is to be washed out, and the patient is to be kept as quiet as pos- sible." (Witthaus' Essentials of Chemistry.) Tetanus is the principal condition from which strychnine poisoning is to be differentiated. In tetanus, the onset is gradual, is apt to begin with trismus, swallowing is diffi- cult or impossible, the condition is persistent, conscious- ness is dulled or lost, and there is history of a wound or injury. In strychnine poisoning, the onset is more sudden, the muscles of the jaw and neck are generally the last to be affected, there are marked remissions with muscular relaxation, consciousness is retained, and there is no his- tory of a wound or injury. Strychnine poisoning is more difficult to prove than arsenic poisoning, because in the latter the poison is not decomposed, and in spite of any chemical change the ele- ment arsenic remains, and may be demcnstrated. This would not be possible in the case of strychnine. 6. (a) As a rule, all bodies expand when heated, and diminish in volume on losing heat. Conduction of heat is its transmission from one mole- cule to the neighboring molecule. Transmission of heat may take place by conduction, con- vection, and radiation. (b) By heat, substances can be converted from the solid state to the liquid state, and from the liquid to the gaseous state, as ice can be converted by heat to water, and then to steam. (c) Specific heat is the amount of heat required to raise the temperature of a substance a given number of degrees. (d) Sources of heat, are: The sun, the interior of the earth, friction, pressure, electricity, chemical action, com- bustion. 7. Iodine is obtained from sea-weed. Sea-weed is burnt, and the ashes (called kelp) are extracted with water and the solution is then evaporated. The mother liquor is then 644 MEDICAL RECORD. distilled with manganese dioxide and sulphuric acid, 4 or the iodine is obtained by passing chlorine in, and heating. The common medicinal preparations, with doses, are : Tincture of iodine, TTJ^ij ; Lugol's solution, rrgij ; potassium iodide, gr. vij ; sodium iodide, gr. vij ; ammonium iodide, gr. iv. 8. (a) Static electricity is electricity at rest; and is usually produced by friction. (b) Dynamic electricity is electricity in motion; it is also . called current electricity. A volt is that electromotive force, which, acting steadily through a conductor having a resistance of one ohm, will produce a current of one ampere. An ohm is the amount of resistance shown by a column of mercury 106.3 centimeters long with a base of one mil- limeter square, at 0°C. An ampere is such a current of electricity as would be given with an electromotive force of one volt through a wire with the resistance of one ohm. SURGERY. 1. By the term Science of Surgery is meant the prin- ciples which underlie the practice of surgery. The Art of Surgery is the practical application of these principles. In Aseptic Surgery everything that is to come in con- tact with the wound is previously made free from germs, and all possibility of infecting the wound is avoided. In Antiseptic Surgery antiseptic solutions are used to kill the bacteria that may be present or that may enter during the course of the operation. 2. Potfs fracture consists of a fracture of the lower end of the fibula, about three inches above the tip of the malleolus ; and a fracture of the internal malleolus. The foot is twisted outward, the sole everted, and the heel drawn up ; there is a depression at the site of the frac- ture, the inner malleolus either projects prominently or the fragment can be felt and crepitus elicited; the foot is shortened, and the ankle is swollen and widened. Pott's fracture is usually caused by twisting the foot. Colles' fracture is a fracture of the lower end of the radius ; it is generally transverse, and is usually within an inch or an inch and a half of the articular surface. There is a characteristic deformity caused by the lower frag- ment and the carpus forming a prominence on the dorsal surface; at the same time there is a projection on the palmar surface just above the wrist, caused by the upper fragment. The hand is abducted and pronated, and the styloid process of the ulna becomes very prominent. A. common result of almost any fracture of a long bone, is shortening of the limb. 645 MEDICAL RECORD. 3. In fecal impaction, there is a history of long con- tinued and increasing constipation, feeling of languor and depression, anorexia ; the abdomen becomes distended gradually, and the symptoms develop slowly; pain comes on gradually, and later becomes continuous; there is usu- ally a tumor in sigmoid flexure or cecum, it is doughy and firm; constipation is absolute. In invagination of the intestine, there is a sudden onset, with severe pain which later tends to subside; rarely con- stipation, but often diarrhea may be present, accompanied with tenesmus ; there is apt to be marked prostration or collapse; a movable tumor can often be felt in line of the colon, or in the rectum ; in extreme case the invagina- tion may protrude from the anus. Method of treating fecal impaction : "The best means of relief are afforded by copious enemata of warm water administered in the knee-and-elbow position. Continuous irrigation by the siphon syringe is very efficacious, and, if employed for half an hour at a time, the hardest mass softens and gradually becomes disintegrated. The stream of water should be directed against the obstructing mass by means of a rectal tube. Before enemata are com- menced it is often advisable to inject a few ounces of olive oil. Some physicians recommend copious injections of sweet oil with spirits of turpentine in the proportion of one drachm to the pint of oil. Metallic mercury has been strongly advocated. Occasionally, when low down, the fecal mass may be removed by scoop or spoon." (From Reference Handbook of the Medical Sciences.) 4. Osteomyelitis is inflammation of the bone and mar- row ; the term is often used now for inflammation of bone. It is caused by infection, the bacteria gaining entrance either through a wound, or by extension from neighboring tissues, or they may be brought by the blood. It is to be diagnosed from (1) Rheumatism, in which more than one joint is affected and the tenderness is in the joint and not near it. (2) Tubercular arthritis, in which the onset is slow, and the trouble starts in the epiphysis rather than in the diaphysis. (3) Cellulitis, in which the bone and periosteum are not affected, and in which there is always a wound. In osteomyelitis, the treatment connsts in relieving the constitutional symptoms, and preventing the bone from necrosing. An incision down to the bone is made; if pus is beneath the periosteum, the latter is also incised; a piece of bone is removed by chisel or trephine, pus is re- moved, the endosteum is hurt as little as possible, the wound is irrigated with hot bichloride solution, and packed with gauze; the soft parts are closed and the wound well drained. In case this fails, amputation may be necessary. 646 MEDICAL RECORD. 5. See Rose and Carless' "Surgery" (1908), pages 954 and 955; or Da Costa's "Surgery" (1908), pages 1234 and 1236. 6. Perineorrhaphy is the operation of suturing a lacer- ated perineum. See Rose and Carless' "Surgery" (1908), page 1280. Trachelorrhaphy is the operation of suturing a lacerated cervix uteri. See Hirst's "Obstetrics" (1909), page 898. 7. Curettage. Procedure: All antiseptic and aseptic pre- cautions are necessary, the patient should be in the dorsal position, the vagina is to be disinfected, and the cervical canal dilated ; a speculus is introduced into the vagina and the cervix is drawn down with volsella ; the uterine cavity is irrigated with creolin or lysol ; a curette is inserted to the fundus and moved down to the internal os ; the oper- ator should begin at one cornu, and go in the same direc- tion all around till he reaches the starting point, and if necessary repeat till no more spongy or hyperplastic tissue appears; the fundus should be scraped separately by mov- ing the curette along it from side to side ; in going to- wards the fundus no scraping should be done, and care must be taken not to perforate the uterus ; should this hap- pen no fluid must be injected ; otherwise the uterus and vagina are again irrigated, and one or more strips of iodo- form gauze are inserted into the cavity to act either as a hemostatic plug or as a drain, which is diminished with two days' interval and withdrawn on the sixth day. A hemostatic tampon should be placed in the vagina and withdrawn the following day. If any fever arises, the tampon is at once removed and the vagina douched with antiseptic fluid every three hours. If not, the vagina is only swabbed with the same every day, and packed looselv with iodoform gauze. After the final removal of the gauze the antiseptic douche is given twice a day until there is no more discharge. The patient should remain in bed for a week. 8. (a) Prostatectomy is the operation of removing the prostate gland, entirely or in part. (b) Cystotomy is the operation of making an incision into the urinary bladder. (c) Nephrectomy is the operation of removing a kidney. (d) Nephrotomy is the operation of making an incision into the kidney. (e) Lithotomy is the operation of removing a calculus by cutting into the urinary bladder. Enucleation of the eyeball is performed as follows: "A general anesthetic is generally given. After introduction of the speculum, the conjunctiva is divided all around the cornea, as close to its border as possible, and dissected back as far as the insertions of the recti muscles. A 647 MEDICAL RECORD. squint hook is passed beneath the tendon of the internal rectus, and the latter is divided with the strabismus scis- sors close to its insertion; then the other straight mus- cles are cut in the same way, together with the subcon- junctival connective tissue for some distance beyond the equator. The points of the scissors must always be di- rected toward the eyeball and the latter stripped as clean as possible to avoid any unnecessary removal of orbital tissue. Instead of commencing with a circumcorneal divis- ion of the conjunctiva, we may begin with a tenotomy of the internal rectus and then divide the conjunctiva as we pass from tendon to tendon. The hook is passed around the globe to make sure that the attachments of the muscles have been completely divided. The eyeball is then dislocated forward by pressing the speculum back- ward, and thus the optic nerve is put on the stretch. A pair of enucleation scissors, closed, are passed between sclera and conjunctiva, feeling for the optic nerve; they are withdrawn, slightly opened, and the nerve is divided close to the sclera. The eyeball is held between the thumb and index finger of the left hand, and the oblique muscles and other unsevered attachments are divided. The orbit is plugged for a few minutes to control hemorrhage, and the conjunctiva is usually closed with a single suture, which is passed through its edge at intervals and tied like the string of a pouch. The eye is bandaged and the patient kept in bed for a day." (May, Diseases of the Eye.) PRACTICE. i. I don't expect to have any puerperal fever in my practice, due to any want of care on my part. The causes of puerperal fever are : Pathogenic bacteria which may be introduced into the woman in several ways, such as by the hands of the physician, nurse, midwife, or of the patient herself; by unclean instruments and catheters; by coitus during the time immediately preceding labor; by contact with secretions from wounds of any kind, no matter where situated ; by general unhygienic surroundings, and contact with a patient suffering from scarlet fever or ery- sipelas on the part of any one attending on the woman. The percentage of such cases will depend on the care exer- cised by doctor, nurse, etc. ; when infection does occur, it is generally streptococcic infection, either pure or mixed with other germs. Puerperal Fever is a fever beginning within a week after labor, attended with acute inflammation of the re- productive organs, and with septic infection of the blood and general system. Treatment: See Williams' "Obstetrics" (1909), page 383; or Hirst's "Obstetrics" (1909), pages 732 and 737. 2. See French's "Practice of Medicine" (1907), pages 648 xMEDICAL RECORD 893, 887, and 891 ; or Osier's "Practice of Medicine" (1909), pages 688, 683, and 702. 3. Gallstones are calculi formed in or found in the gall- bladder or bile ducts. The technical name is Cholelithiasis. The diagnosis is made by (1) the intense and sudden pain, radiating from the right hypochondriac region to the right shoulder. (2) Cold sweat, feeble pulse, vomiting, and collapse may be present. (3) Chill and fever are present at the onset. (4) The calculus may be found in the feces. Treatment. Prophylaxis includes: Plain and easily di- gested food, the ingestion of plenty of good drinking water between meals, sufficient outdoor exercise, salines, and the avoidance of indigestion. During an attack : Inhalation of chloroform, a hypo- dermic of morphine (gr. 1/4) and atropine (gr. 1/120), application of heat, and diffusible stimulants if shock is present. Cholecystotomy may be performed, and the stones re- moved. 4. See French's "Practice of Medicine" (1907), pages 424 and 429; or Osier's "Practice of Medicine" (1909), pages 269 and 280. 5. (a) For General Debility: R. Strychninae sulphatis, gr. j. Quininae sulphatis, 3j. Tincturae ferri chloridi, 3iij. Acidi phosphorici diluti, 3y. Glycerini q.s. ad Jv. Misce. Signa : One teaspoonf ul after each meal. (b) For Acute Bronchial Cough: IJ. Ammonii carbonatis, gr. xxxij. FL extr. senegae. Fl. extr. scillae, aa 3j. Tincturae opii camphoratae, 3vj. Aquae destillatae, 3iv. Syrupi Tolutani q.s. ad Jiv. Misce. Signa : One teaspoonful every three hours. (c) For Chronic Constipation : It. Fl. extr. cascarae sagradae, Jss. Tincturse nucis vomicae, 3v. Tincturae belladonnae, 3ij. Glycerini q.s. ad 3ij- Misce. Signa : One teaspoonful three times a day. (d) For Chronic Diarrhea: B. Morphinae sulphatis, gr. j. Bismuthi subnitratis, 3j. Misce. Et fiat in chart, no. xij. Signa : I ake one powder three or four times a day. 649 MEDICAL RECORD. 6. See French's "Practice of Medicine" (1907), pages 222, 225, and 230; or Osier's "Practice of Medicine" (1909)* pages 219, 221, 223, and 226. 7. See French's "Practice of Medicine" (1907), page 784; or Osier's "Practice of Medicine" (1909), page 508. 8. See French's "Practice of Medicine" (1907), page 528; or Osier's "Practice of Medicine" (1909), page 745. PATHOLOGY. 1. By active pathological change is understood that con- dition in which formation exceeds waste, and growth re- sults. Examples : Hypertrophy, Tumor-formation, Regen- eration. By passive pathological change, is understood that con- dition in which morbid processes are attended by arrest or impairment of nutrition. Examples : Atrophy, Degen- erations, Infiltrations, Necrosis. 2. See French's "Practice of Medicine" (1907), page 878; or Osier's "Practice of Medicine" (1909), page 667. 3. See French's "Practice of Medicine" (1907), page 892; or Osier's "Practice of Medicine" ^ (1909), page 687. 4. The bile capillaries in the liver are distended with bile, and the hepatic cells are pigmented. 5. See French's "Practice of Medicine" (1907), page 671; or Osier's "Practice of Medicine" (1909), page 622. 6. See French's "Practice of Medicine" (1907), page 182; or Osier's "Practice of Medicine" (1909), pages 194 and 198. 7. In malaria, the spleen is much enlarged, and is of a brownish color, with areas of deep pigmentation; the capsule is thickened. 8. See French's "Practice of Medicine" (1907), page 219; or Osier's "Practice of Medicine" (1909), page 210. STATE BOARD EXAMINATION QUESTIONS. Texas State Board of Medical Examiners. anatomy. 1. Describe the tibia and name the muscles attached. 2. Describe the collateral circulation around the knee. 3. Describe the kidney. 4. Name the muscles of the femoral region. 5. Give subdivision of the large intestines and source of blood supply to each. 6. Give origin, course and distributien of the ulnar nerve. 7. Give origin, course and distribution of the radial artery. 650 xMEDICAL RECORD. 8. Give the origin, course and distribution of the dor- salis pedis artery. 9. Describe Hunter's canal, naming the structures found therein, and their relation to each other. 10. What structures would you cut through in an am- putation at the middle of the humerus? HISTOLOGY. 1. Give the divisions of the urethra and give histology of the prostatic portion. 2. What is the pelvis of the kidney? 3. Describe nonstriated muscular tissue and name its principal locations in the body. 4. Give histology of arteries, veins and capillaries. 5. Name the tunics of the eyeball and give its re- fractive media. 6. Describe a lobule of the lung. 7. For description the olfactory organ is divided into three regions; name them, and give histology of the Schneiderian membrane. 8. Name the three divisions of ear, and the bones of the middle ear. 9. Describe the musculature of the uterus. 10. Describe the mucosa of the stomach. PHYSIOLOGY. 1. Name the glands secreting the saliva. 2. Give specific gravity, chemical reaction, and physi- ological reaction of saliva. 3. Give name, origin, distribution, and function of the fifth cranial nerve. 4. Where are the following cerebral nerve centers: (a) saliary, (b) visual, (c) respiratory, (d) mastication, and (e) micturition? 5. Given an exposed artery and vein in the living sub- ject, how would you distinguish them without reference to anatomical landmarks ? 6. What portion of the spinal cord is affected (in volved) in locomotor ataxia? 7. Describe the physiologic functions of the kidneys. 8. Name the four divisions of the circulatory system and describe the circulation of the blood. 9. Describe the portal circulation ; name vessels carry- ing the blood to and from the liver and into what does the latter empty? 10. Define (a) hyperopia, (b) heterophonia, (c) eu- thanasia (d) myopia, (e) necremia, (/) hydremia, (g) diopter, (h) aphasia, (t) astigmatism, (/) chyluria. CHEMISTRY. i. Describe the chemical change in starch during di- gestion. 651 MEDICAL RECORD 2. Describe oxygen. 3. What are the symptoms of acute arsenic poisoning? 4. Give chemistry of respiration. 5. Give the chemical formula for alcohol ; for ether. 6. To what salts do most cathartic mineral waters owe their virtue? 7. Give two chemical tests for albumin in the urine. 8. Give two chemical tests for sugar in the urine. 9. Give the formula and properties of chloroform. 10. Define an alkaloid and name several used in medi- cine. BACTERIOLOGY. 1. Name and give classification of fungi that are con- nected with diseases in man. 2. Name chief forms of bacteria. 3. Name the most important surgical microorganisms, i.e. those most frequently met with in surgical work. 4. What bacteria are likely to be mistaken for the tubercle bacillus, and how may this error be avoided? 5. Describe ptomains and name three sources of ptomain poisoning. 6. Give detailed description of Widal's microscopical test in typhoid fever. 7. Name and describe a malarial parasite. 8. Define (a) phagocytosis, (h) chemotaxis, (c) op- sonin. 9. State accurately the steps you would take to stain, mount and examine a specimen of sputum from an ad- vanced case of tuberculosis. 10. Define (a) aerobic, (b) anaerobic, (c) diplococci. PATHOLOGY. 1. What are the pathological changes that take place in the blood in malarial fever? 2. Lobar pneumonia; name its different stages and describe each. 3. Describe the characteristic lesions of typhoid fever. 4. Pathology of empyema. 5. Pathology of erysipelas. 6. Pathology of acute gastroenteritis. 7. Pathology of diphtheria. 8. Describe union by first intention; describe union by second intention. 9. Hernia — Name three varieties of external hernia, and give usual contents of the sac in oblique inguinal. 10. W T hat is the pathology of rheumatism? PRACTICE OF MEDICINE. I. Give diagnostic significance from topographical oc- currence of edema. 652 MEDICAL RECORD 2. State clinical significance of arrhythmia (irregular pulse), and its principal varieties. 3. Describe symptoms of aneurysm of ascending aorta. 4. Differentiate between acute pericarditis, acute endo- carditis, and acute myocarditis. 5. Differentiate between acute pneumonia and exudat- ive pleuritis. 6. Differentiate between hypertrophy and dilatation of heart. 7. Differentiate between acute miliary tuberculosis and enteric fever. 8. State symptoms of gastroptosis. 9. Discuss acute yellow atrophy of liver. 10. Differentiate carcinoma of stomach and chronic pancreatitis. OBSTETRICS. 1. Describe fertilization of the ovum. 2. Describe the placenta and give its functions. 3. Give normal duration of pregnancy and method of calculating duration. 4. Give some of the most reliable signs of pregnancy. 5. Differentiate between a first and a subsequent preg- nancy as regards changes in the uterus. 6. Give causes of vomiting in pregnancy. 7. What conditions in pregnancy are dangerous to the life of mother and child? 8. Define placenta previa; classify, and give treatment. 9. What is the significance of albuminuria in preg- nancy? And give treatment. 10. Name some conditions which might complicate pregnancy or be mistaken for it. GYNECOLOGY. 1. Give blood supply, and nerve supply, and lymphatics of the womb and ovaries. 2. Define kraurosis vulvae. 3. Give cause of inversion of the uterus, its diagnosis. 4. W T hat are symptoms, and cause of pudendal hema- tocele? 5. What is caruncle of the urethra? 6. Give differential diagnosis of tuberculous and gonor- rheal cystitis. 7. What are the causes of pelvic peritonitis? 8. Give differential diagnosis of acute salpingitis, oophoritis, and appendicitis. 9. What is pathology of (a) hydrosalpinx, (b) hema- tosalpinx? Give diagnosis. 10. What is acute parametritis? Give its etiology, pathology. 6'^ MEDICAL RECORD. SURGERY. i. What is an aneurysm? 2. What is a fracture? 3. What is a contused and lacerated wound? 4. Describe Colles' fracture and give treatment. 5. What is your treatment in Pott's fracture? 6. Describe an amputation of lower third of thigh. 7. How would you treat a case of wry neck? 8. What is fistula in ano, and how treat it? 9. Describe technique of appendectomy. 10. Give symptoms and operative technique for gall- stones. HYGIENE. 1. Mention and describe the diseases of animals that are communicable to man, and state the means that should be employed for the prevention of these diseases in man. 2. What are the alimentary principles of food, their functions, the object of cooking food? 3. What is the object of clothing, its virtue in different seasons; with reference to material, color, texture, and hygroscopic quality? 4. Give the best methods of disinfecting a room and contents after exposure to the contagion of smallpox. 5. When are diseases said to be "epidemic," "pandemic," "endemic" ? 6. Classify the following diseases, whether contagious or infectious : typhoid fever, typhus fever, cholera, scar- let fever, smallpox, yellow fever. Give method of stamp- ing them out. 7. What is the difference between fermentation, oxida- tion, and putrefaction? 8. What deleterious gases accumulate in an imperfectly ventilated schoolroom ? State amount of fresh air required per minute for each child. ^ Also state the evil effects from inhaling air rendered impure by respiration. 9. Define ptomain. Give sources of origin and de- scribe their agency in inducing diseases and give the symptom produced by them. 10. How would you guard against the bowel disturb- ance of infants during their first and second summers? MEDICAL JURISPRUDENCE. i. What is meant by last sickness, and what are its relations to the law? 2. How may human hairs be distinguished from fibers or the hair of the other animals? 3. What are the most important questions arising in connection with gunshot wounds? 654 MEDICAL RECORD. 4. What is the cause of death following burns? 5. How is it possible to distinguish false from true pregnancy? 6. How do you distinguish between injuries to the head, produced during delivery by accident, and those made with criminal intent? 7. What is meant by the age of consent? 8. What is meant by the expectation of life? 9. Describe the coroner system. 10. What is a wound and what are the most important questions that arise in connection with wounds? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Texas State Board of Medical Examiners. anatomy. 1. For description of tibia, see Cunningham's "Anatomy" (1909), page 230; or Gray's "Anatomy" (1908), page 234. Muscles attached are: Semimenbranosus, tibialis anticus, extensor longus digitorum, biceps, sartorius, gracilis, semi- tendinosus, tibialis anticus, popliteus, soleus, flexor longus digitorum, and tibialis posticus. 2. The arterial anastomosis about the knee-joint is formed as follows: (1) The superior external articular artery anastomoses with the descending branch of the external circumflex, the inferior external articular, the anastomotica magna and the superior internal articular. (2) The superior internal articular artery anastomoses with the anastomotica magna, the inferior internal articular, and the superior external articular. (3) The inferior ex- ternal articular artery anastomoses with the inferior in- ternal articular, the superior external articular, and the anterior recurrent branch of the anterior tibial. (4) The inferior internal articular artery anastomoses with the in- ferior external articular, and the superior internal articular. The whole forms a superficial and deep plexus ; the former being situated between the fascia and skin round the patella, and the latter on the articular surfaces of the lower end of the femur and the upper end of the tibia. 3. See Cunningham's "Anatomy" (1909), page 1130; or Gray's "Anatomy" (1908), page 1419. 4. Muscles of the femoral region, are: Tensor vaginae femoris, Sartorius, Quadriceps extensor femoris (Vastus externus, Vastus internus, Rectus femoris, Crureus), Sub- crureus, Gracilis, Pectineus, Adductor longus, Adductor magnus, and Adductor brevis. 655 MEDICAL RECORD. 5- SUBDIVISIONS OF LARGE INTES- TINES. Ileocecal valve Cecum \- (Appendix) j Ascending colon Transverse colon Descending colon Sigmoid flexure Rectum ARTERIAL SUPPLY. Ileocolic and Right colic Right colic Middle colic Left colic Sigmoid Superior hemor- rhoidal Middle hemor- rhoidal Inferior hemor- rhoidal BRANCH OF > Superior mesen- teric Inferior mesen- teric Internal iliac Internal pudic 6. See Cunningham's "Anatomy" (1909), page 629; or Gray's "Anatomy" (1908), page 1005. 7. See Cunningham's "Anatomy" (1909), page 831; or Gray's "Anatomy" (1908), page 659. 8. See Cunningham's "Anatomy" (1909), page 868; or Gray's "Anatomy" (1908), page 713. 9. Hunter's canal occupies the middle third of the thigh, beginning at the apex of Scarpa's triangle, and ex- tending to the femoral opening in the Adductor magnus muscle. It is bounded externally by the Vastus inter- nus ; internally by the Adductors longus and magnus. It is covered in by a fibrous expansion from the Vastus internus to the Adductors ; over this roof lies the Sartorius. It con- tains the femoral artery, and femoral vein, in a sheath; and the long saphenous nerve outside the sheath. The vein is behind and external to the artery; the nerve is at first external to the vessels, then it crosses over them. 10. Structures cut in an amputation at the middle third of the humerus, are : Skin ; fascia ; muscles : biceps, coraco- brachial, brachialis anticus, triceps ; arteries : brachial, superior profunda, inferior profunda; veins: basilic, ce- phalic, brachial, superior profunda, inferior profunda; nerves : median, ulnar, musculo-spiral, internal cutaneous, musculo -cutaneous ; bone : humerus. HISTOLOGY. 1. See Cunningham's "Anatomy" (1909), page 1177; or Gray's "Anatomy" (1908), page 1450. 2. See Cunningham's "Anatomy" (1909), page 1141; or Gray's "Anatomy" (1908), page 1424. 3. Nonstriated muscular tissue "is the simplest form of muscular tissue. The cells are nononucleated, elongated, 656 MEDICAL RECORD or spindle shaped, and vary in length from 40 to 200 microns. The nucleus occupies the center of the cell, is rich in chromatin, and oval, with blunt ends or cigar- shaped. The cytoplasm is longitudinally striated, the stria- tions being due to fibrils or sarcostyles, which are, struc- turally, probably analogous to the spongioplasm. Between the fibrils there is a homogeneous substance, the sarco- plasm, which is analogous to the hyaloplasm. These cells are enclosed in a delicate cement layer usually not de- scribed as a cell wall. The ends overlap each other and are held together by a delicate cement substance. Nerve fibers from the sympathetic nervous system reach the mus- cle cells and terminate in small granules upon the muscle cytoplasm/' "It is found in the wall of the alimentary tract, trachea and bronchi, bladder, ureter, uterus, Fallopian tubes, urethra, vas deferens, blood-vessels, lymph-vessels, large ducts of glands, nipple, hair-follicles, Eustachian tube, spleen, prostate gland, ciliary muscles, and iris of the eye." — (Hill's Histology.) 4. See Cunningham's "Anatomy" (1909), page 780; or Gray's "Anatomy" (1908), pages 586, and 722. 5. The tunics of the eye, are: (1) Sclerotic and cornea; (2) choroid, ciliary body, and iris; (3) retina. The re- fracting media are: (1) Aqueous humor; (2) vitreous body; (3) crystalline lens. 6. See Cunningham's "Anatomy" (1009), page 990; or Gray's "Anatomy" (1908), page 1404. 7. The three regions of the olfactory organ, are: (1) The vestibule; (2) the respiratory part; (3) the olfactory part. For Schneiderian membrane, see Cunningham's "Anatomy" (1909), page 722 ; or Gray's "Anatomy" (1008), page 1 1 10. 8. ihree divisions of the ear: (1) External ear; (2) middle ear. or tympanum; (3) internal ear, or labyrinth. Bones of middle ear: Malleus, incus, and stapes. 9. See Cunningham's "Anatomy" (1909), page 1191; or Gray's '"Anatomy" (1908), page 1504. 10. See Cunningham's "Anatomy" (1909), page 1059; or Gray's "Anatomy" (1908), page 1283. PHYSIOLOGY. 1. The glands secreting the saliva, are: The parotid, submaxillary and sublingual glands (and the small mucous and serous glands of the mouth). 2. Saliva. Specific gravity: about 1002 to 1006. Chem- ical reaction: Alkaline. Physiological reaction: Through the ptyalin which it contains, il begins to convert starch into maltose. 657 MEDICAL RECORD. 3. Fifth Cranial Nerve. Name: Trigeminal, or tri- facial nerve. Origin: (1) Superficial — from the side of the pons varolii; (2) Deep — from the medulla, and the floor of the fourth ventricle. Distribution: First, or ophthalmic branch, to conjunc- tiva, and skin of upper eyelid, cornea, skin of forehead, and nose, lachrymal gland, and skin of nose. Second, of superior maxillary branch, to skin and conjunctiva of lower eyelid, nose, cheek, upper lip, upper teeth, and palate. Third, or inferior maxillary branch, to external auditory meatus, side of head, mucous membrane of mouth, anterior two-thirds of tongue, lower teeth, and skin of lower part of face. Also to muscles as indicated under Function. Function: It supplies sensation to all the parts mentioned above; but, in addition, the Inferior maxillary branch sup- plies motion to the muscles of mastication (Masseter, Tem- poral, External, and Internal Pterygoids), and the Mylo- hyoid, and anterior belly of the Digastric. 4. (a) The salivary center, is in the medulla; (b) visual center, is in the occipital lobes; (c) respiratory center, is in the medulla; (d) center for mastication, is in the me- dulla; (e) center for micturition, is in the lumbar enlarge- ment of the spinal cord. 5. Arteries are recognized by: (1) their pulsation, when no proximal constriction is used; (2) their swelling prox- imally when compressed distally (where no constrictor is used); (3) their firm, round, resisting, elastic, cord-like feeling; (4) their peculiar sensation when compressed be- tween the fingers, presenting a central depression and two lateral, elevated ridges; (5) their thicker walls; (6) their rubber-tube-like feeling when touched and tendency to glide from beneath the fingers; (7) the force required to com- press them; (8) their regular outline; (9) their pinkish or pinkish-yellow color. Veins are recognized by: (1) not pulsating (where no Esmarch is used) ; (2) by having thinner coats ; (3) by swelling toward the periphery when compressed centrally (no constrictor being used) ; (4) by being softer and less resisting to touch; (5) by the flat, ribbon-like feeling throughout their whole width when compressed between the fingers; (6) by their purplish color; (7) by their wavy, irregular contour; (8) by their accompanying the arteries, in many regions, in pairs or companion veins; (9) by their larger size than the corresponding arteries; (10) by the ease with which they are compressed. (From Bickham's Operative Surgery.) 6. The posterior columns of the spinal cord are in- volved in locomotor ataxia. 7. The function of the kidneys, is: (1) To secrete (or 658 MEDICAL RECORD. excrete) urine; (2) the production of an internal secre- tion. The mechanism of the secretion of urine by the kidneys is twofold: (1) By filtration, most, if not all, of the fluid is eliminated, and also inorganic salts; this depends upon blood pressure, and takes place in the glomeruli. (2) By cell activity and selection, in the cells of the convoluted tubules, the urea and principal solids are eliminated. 8. The four divisions of the circulatory system, are: (1) The heart; (2) arteries; (3) capillaries, and (4) veins. And see Gray's "Anatomy'' (1908), page 557. The circulation of the blood is regulated in (a) the arteries by: (1) The elasticity and tone of the arteries, (2) the force and frequency of the cardiac contractions, (3) the resistance in the capillaries; (b) in the capillaries it is regulated by (1) the action of the heart, (2) the ac- tion of the arteries; (c) in the veins it is regulated by (1) the action of the heart, (2) aspiration of the thorax, (3) the contraction of the muscles, and (4) slightly by the valves in the veins. g. The vessels that carry blood to the liver, are the hepatic artery and the portal vein ; the vessels that carry blood from the liver, are the hepatic veins, which empty into the inferior vena cava. And see Cunningham's "An- atomy" (1909), pages 902 and 1120; or Gray's "Anatomy" (1908), pages 768 and 1346. 10. (a) Hyperopia is a condition in which the antero- posterior axis of the eye is abnormally short, and parallel rays are focused behind the retina. (b) Heterophoria is a condition in which the visual axes of the eyes tend to deviate. (c) Euthanasia is painless and easy death. (d) Myopia is a condition in which the anteroposterior axis of the eye is abnormally long, and parallel rays are focused in front of the retina. (e) Necremia is death of the blood. (/) Hydremia is a watery condition of the blood. (g) Diopter is the unit of measurement for refractive power; it represents the refractive power of a lens at a focal distance of one meter. (h) Aphasia is loss of the power of expression by speech or writing. («) Astigmatism is a condition in which owing to a greater curvature of the eye in one meridian than in others, the refractive power of the eye varies. (/) Chyluria is a condition in which the urine appears to be milky, from the presence of fat. CHEMISTRY. i. During digestion, starch (by means of the ptyalin of 659 MEDICAL RECORD. the saliva, and the amylopsin of the pancreatic juice) is converted into dextrin and maltose. The dextrin is after- ward converted into maltose also. 2. Oxygen is a colorless, odorless, tasteless gas, heavier than air, slightly soluble in water, has an intense affinity for other elements, combining with almost all of them except fluorine. It is necessary to life, and is a supporter of combustion. It occurs free in the air and in combina- tion in water, rocks, minerals, etc. It is more abundant than any other element, forming about 40 per cent, of the total weight of the earth. 3. The symptoms of acute arsenical poisoning: "In acute cases the symptoms usually begin in from twenty to forty-five minutes. Nausea and faintness. Violent,, burn- ing pain in the stomach, which becomes more and more intense, and increases on pressure. Persisting and dis- tressing vomiting of matters, sometimes brown or gray, or streaked with blood, or green (Paris green). Purging. More or less severe cramps in the lower extremities." (Witthaus' Essentials of Chemistry.) 4. The chemical changes produced in the air by respira- tion are : Oxygen Nitrogen Carbon dioxide . . Other gases Watery vapor INSPIRED AIR. 21 per cent. 79 per cent. 0.04 per cent Rare. Variable. EXPIRED AIR. 16.6 per cent. 79 per cent. 4.4 per cent Often present. Saturated. In the blood the chemical changes are: (1) The giving up of the CO a by the venous blood; (2) the absorption of oxygen during inspiration, and (3) the blood loses a small amount of watery vapor. 5. The chemical formula for alcohol, is C2H5OH ; for ether, is (C 2 H 6 )2 O. 6. Most cathartic mineral waters owe their virtue to the following salts : Magnesium sulphate, sodium sulphate. 7. TWO TESTS FOR THE DETECTION OF ALBUMIN IN THE urine: "The urine must be perfectly clear. # If not so, it is to be filtered, and if this does not render it transparent, it is to be treated with a few drops of magnesia mixture and again filtered." I. — The heat test: 'The reaction is first observed. If it be acid, the urine is simply heated to near the boiling point. If the urine be neutral or alkaline, it is rendered faintly acid by the addition of dilute acetic acid, and heated. If albumin be present, ^ a coagulum is formed, varying in quantity from a faint cloudiness to entire solidification, according to the quantity of albumin present. 660 MEDICAL RECORD. The coagulum is not redissolved upon the addition of HNO.." II. — Hellers modification of the nitric acid test: "Place in a test-tube^ a layer of HNG 3 about 2 centim. in thick- ness ; then, with a pipette carefully float upon the surface of this a layer of the urine in such a manner that the liquids do not mix. If albumin be present, a cloudy ring appears at the point of junction of the two layers, the borders of the cloud being sharply defined. A cloudy ring may be formed by the presence of an excess of urates, but in this case it is not at, but above, the point of junc- tion of the layers, and its upper border is not sharply de- fined, but fades oft gradually." (Witthaus' Essentials of Chemistry.) 8. TWO TESTS FOR THE DETECTION OF SUCAR IN THE urine : The urine should first be tested for albumin. If this be present, it should be removed by heating the urine to near the boiling point, and filtering from the coagulum. (1) Fcliling's test: Place in a test-tube a few c.c. of the liquid prepared as stated below, and boil; no reddish tinge should be observable, even after five minutes' re- pose. Add the liquid under examination gradually, and boil after each addition. In the presence of sugar a yellow or red precipitate is formed. In the presence of traces of glucose, only a small amount of precipitate is produced, which adheres to the glass, and is best seen when the blue liquid is poured out. [The reagent must be kept in two solutions, which are to be mixed immediately before use. Solution I consists of 34.653 gms. of crystallized CuS0 4 , dissolved in water to 500 c.c. ; and solution II of 130 gms. of Rochelle salt dissolved to 500 c.c. in NaHO solution of sp. gr. 1.12. When required for use equal volumes of the two solu- tions are mixed, and the mixture diluted with four vol- umes of water.] - (2) Boettger J s test: Render the urine strongly alkaline by addition of Na^COs. Divide about 6 c. c. of the alkaline liquid in two test-tubes. To one test-tube add a very minute quantity of powdered subnitrate of bismuth, to the other as much powdered litharge. Boil the contents of both tubes. The presence of glucose is indicated by the dark or black color of the bismuth powder, the litharge retaining its natural color. (From Witthaus' Essentials of Chemistry.) 9. Chloroform. Formula: CHCls. Properties: It is a colorless liquid, volatile, with a sweet taste, and agree- able odor. It is heavier than water; is a good solvent for fats and other substances ; it mixes with alcohol, and ether, but not with water. 10. An alkaloid is a basic nitrogenous substance of alka- 661 MEDICAL RECORD. line reaction and capable of combining with an acid to form salts in the same way that ammonia does. Several alkaloids used in medicine: Strychnine, quinine, cocaine, atropine, morphine, codeine, pilocarpine, apomor- phine, aconitine, eserine. BACTERIOLOGY. 1. The fungi which are connected with diseases in man, are: (i) The Blastomycetes, or yeasts. (2) The Hyphomycetes, or moulds; and (3) The Schizomycetes, or bacteria. 2. The three basic forms of bacteria are: (i)^ The coccus, which is round or oval, and may appear singly, in pairs, in groups of four, in chains, or in bunches. (2) The bacillus, which is rod shaped, with the longer sides parallel, and the short ends either straight, rounded, or concave. (3) The spirillum, which is spiral. 3. The most important surgical microorganisms, are: Staphylococcus pyogenes aureus, staphylococcus pyogenes albus, staphylococcus pyogenes citreus, staphylococcus ce- reus aureus, staphylococcus cereus albus, staphylococcus ce- reus flavus ; streptococcus pyogenes ; micrococcus tetrage- nus, micrococcus pyogenes tenuis ; gonococcus ; pneumoc- occus; bacillus pyocyaneus, bacillus typhosus, bacillus tu- berculosis; streptococcus of erysipelas; bacillus of tetanus; bacillus of anthrax; bacillus coli communis; and spirocheta pallida. 4. The bacteria liable to be mistaken for the tubercle bacillus, are: the bacillus of leprosy, the bacillus of the smegma, and Lustgarten's bacillus. "The differential diag- nosis between these four organisms depends upon the fol- lowing reactions : When stained by the carbol-fuchsin method, commonly employed in staining the tubercle bacil- lus, the Lustgarten's bacillus becomes almost instantly de- colorized by treatment with mineral acids, particularly sul- phuric acid ; whereas the smegma bacillus resists such treatment for a much longer time, and the lepra and tuber- cle bacillus for a still longer time. On the other hand, if decolorization is practised with alcohol instead of acids, the smegma bacillus is the first to lose color. The bacillus tuberculosis and the bacillus of leprosy are both very re- tentive of their color, even after treatment with acids and alcohol. If, then, we treat the preparation, stained with carbol-fuchsin, with sulphuric acid, Lustgarten's bacillus becomes almost at once decolorized. If it is not imme- diately decolorized, heat with alcohol ; if it is then decol- orized, it is the smegma bacillus. If it is still not decol- orized, it is either the leprosy or the tubercle bacillus." (From Park's Pathogenic Bacteria.) 662 MEDICAL RECORD. 5. Ptomains are basic, nitrogenous organic substances produced from protein material by the bacteria which cause putrefaction. "Owing to the wide variations in the chemical constitution of the ptomains, they possess no characters by which they can be distinguished as a class. Some are strongly alkaline and basic, others only feebly so. Some are liquid, oily and volatile, others fixed and crys- talline. Some are very prone to oxidation, and are active reducing agents, others are quite stable. For the same rea- son, no analytical method is possible by which vegetable alkaloids and ptomains can be separated from each other en masse, nor are any reactions known to which all pto- mains respond while vegetable alkaloids do not, or the reverse." (Witthaus' Manual of Chemistry.) Three sources of ptomain poisoning: Canned meats, ice- cream, and decomposing fish. 6. Widal's test in typhoid fever "depends upon the fact that serum from the blood of one ill with typhoid fever, mixed with a recent culture, will cause the typhoid bacilli to lose their motility and gather in groups, the whole called 'clumping/ Three drops of blood are taken from the well-washed aseptic finger tip or lobe of the ear, and each lies by itself on a sterile slide, passed through a flame and cooled just before use ; this slide may be wrapped in cotton and transported for examination at the labora- tory. Here one drop is mixed with a large drop of sterile water, to redissolve it. A drop from the summit of this is then mixed with six drops of fresh broth culture of the bacillus (not over twenty-four hours old) on a sterile slide. From this a small drop of mingled culture and blood is placed in the middle of a sterile cover-glass, and this is inverted over a sterile hollow-ground slide and examined. * * * A positive reaction is obtained when all the bacilli present gather in one or two masses or clumps and cease their rapid movement inside of twenty minutes." (From Thayer's Pathology.) 7. See French's "Practice of Medicine" (1907), page 233; or Osier's "Practice of Medicine" (1909), page 12. 8. (a) Phagocytosis is the faculty of certain cells (notably the mononuclear and polynuclear leucocytes) to take up and destroy bacteria. (b) Chemotaxis is. the property by virtue of which cer- tain living cells approach (positive chemotaxis) or move away from (negative chemotaxis) certain other cells or substances. (c) Opsonin is that quality of a serum which makes a microorganism more susceptible to phagocytosis. 9. To demonstrate the existence of tubercle bacilli in the- sputum: The sputum must be recent, free from par- ticles of food or other foreign matter; select a cheesy- 663 MEDICAL RECORD. looking nodule and smear it on a slide, making the smear as thin as possible. Then cover it with some carbol-fuch- sin, and let it steam over a small flame for about two minutes, care being taken that it does not boil. Wash it thoroughly in water and then decolorize by immersing^ it in a soludon of any dilute mineral acid for about a min- ute. Then make a contrast stain with solution of Loeffler's methylene blue for about a minute ; wash it again and ex- amine with oil immersion lens. The tubercle bacilli will appear as thin red rods, while all other bacteria will ap- pear blue. 10. (a) Aerobic is a term which denotes that a micro- organism requires the presence of oxygen as an essential to its growth. (b) Anaerobic is a term which denotes that a micro- organism requires the absence of oxygen as an essential to its growth. (c) Diplococci are cocci (see Answer 2 above) associ- ated in pairs. PATHOLOGY. 1. The pathological changes that take place in the blood in malarial fever, are: The red cells are destroyed, and therefore reduced in number; the red cells lose their col- oring matter; the serum is colored with hemoglobin; granular pigment appears in the blood; the Plasmodium malariae may be found in the blood; the white cells may be diminished; the total quantity of the blood is dimin- ished; the specific gravity of the blood decreases. 2. See French's "Practice of Medicine" (1907), page 154; or Osier's "Practice of Medicine" (1909), page 170. 3. See French's "Practice of Medicine" (1907), page 70; or Osier's "Practice of Medicine" (1909), page 65. 4. See French's "Practice of Medicine" (1907), page 695; or Osier's "Practice of Medicine" (1909), page 649. 5. See French's "Practice of Medicine" (1907), page 219; or Osier's "Practice of Medicine" (1909), page 211. 6. See French's "Practice of Medicine" (1907), page 780. 7. See French's "Practice of Medicine" (1907), page 182; or Osier's "Practice of Medicine" (1909), page 198. 8. Healing by first intention: "Exudation of plasma from the neighboring blood-vessels occurs, and its fibrinogen is converted into fibrin, so gluing the edges of the wound together, leucocytes are poured out and infiltrate the wound, absorbing any blood clot present. These are fol- lowed by fibroblasts (connective-tissue cells), which take their place. New capillaries form by budding out from adjacent ones, and vascularize the new tissue. Fibrous tissue is formed by intercellular exudation from the fibro- blasts and so the fibrocicatrical union is complete, for at 664 MEDICAL RECORD. the same time epithelium is spreading over the narrow sur- face line." Healing by granulation or second intention occurs when the ede-es of the wound have not been brought together. "Exudation of plasma and leucocytes occurs, followed by fibroblasts and budding from the capillaries, thus forming granulation tissue. The dead tissues or sloughs are sep- arated, and a red area of granulation is then exposed. The deeper layer of granulation tissue is converted into fibro- cicatricial tissue, which contracts, and so the wound grad- ually lessens in size. In the meantime epithelium spreads in from the edge over the surface, and so the scar is com- pleted."— (A ids to Surgery.) 9. Three varieties of external hernia: Inguinal, femoral, and umbilical. Usual contents of the sac in oblique inguinal hernia: Intestine and omentum. 10. See French's "Practice of Medicine" (igoy), page 224; or Osier's "Practice of Medicine" (1909), page 221. PRACTICE OF MEDICINE. i. Topographical occurrence of edema. A. General edema: (1) Beginning at the feet and extending upwards — cardiac weakness or disease. (2) Beginning in the face and extending downwards — renal disease. (3) Beri-beri, multiple peripheral neuritis, trichinosis, and lymphedema. B. Edema of upper half of body: (1) In early stage of renal dropsy. (2) Of arms, head, and neck, in thoracic aneurysm, large double hydrothorax, and mediastinal tumor. (3) Edema of one arm, in enlarged lymphatic glands and tumors, and thrombosis of axillary vein. C. Edema of lower half of body: (1) In early stage of cardiac dropsy. (2) Hepatic cirrhosis. (3) Abdom- inal tumors, enlarged liver, spleen, pancreas, or mesenteric glands. (4) Chronic malarial poisoning, anemias, cachexia, wasting diseases, long continued slight hemorrhages, throm- bosis of femoral vein, lymphedema. D. Circumscribed, and usually single swellings: (1) Over precordial space, in purulent pericarditis. (2) Over affected side, in empyema. (3) Over mastoid process, in mastoiditis. (4) Over parotid gland, in mumps or parotid suppuration. (5) In right hypochondrium, in hepatic ab- scess. (6) Over posterior lumbar region, in perinephritic abscess. E. Circumscribed multiple swellings: In angioneurotic edema, purpuric edema, and giant urticaria. (Condensed from Butler's Diagnostics of Internal Medicine.) 2. Cardiac arrhythmia has no particular clinical sig- nificance, unless it accompanies some disease. According to Butler (Diagnostics of Internal Medicine), search should 665 MEDICAL RECORD. be made for one or more of the following: (i) Valvular cardiac disease, especially mitral lesions, in which it is usually, but not always, a sign of beginning failure of com- pensation, passing in many instances into delirium cordis; simple dilatation, chronic myocarditis, sclerosis of the cor- onary arteries, and fatty degeneration; possibly obscure changes in the cardiac ganglia, and overstrain or impaired nutrition in wasting diseases or long-continued fevers. (2) Poisons circulating in the blood, such as alcohol, coffee, tea, tobacco, digitalis, aconite, and belladonna, or the tox- ines of the infectious diseases, especially of typhoid fever and pneumonia. (3) Diseases of the intracranial contents, meningitis, hemorrhage, abscess, softening, concussion, and not infrequently mental excitement. (4) Neurasthenic conditions resulting from excesses or overstrain. Brief at- tacks of moderate arrhythmia are not uncommon in neu- rotic individuals, following even a slight departure from their usual habits in food, drink, or exertion. (5) Diges- tive disturbances, acute or chronic, and jaundice or consti- pation, particularly if associated with an unusually hypo- chondriacal frame of mind. (6) More rarely arthritis de- formans, exophthalmic goiter, and renal disease. 3. See French's "Practice of Medicine" (1907), page 630; or Osier's Practice of Medicine" (1909), page 855. 4. See French's "Practice of Medicine" (1907), pages 562, 571, and 603; or Osier's "Practice of Medicine" (1909), pages 777, 781, 791, and 824. 5. ACUTE PNEUMONIA. Onset very sudden and sym- toms severe — convulsions, etc., cough first, followed by pain in the side. Temperature very high, 104 or often 105 F. Pulse - respiration ratio greatly disturbed. Bright crimson flush on the cheeks, and the muscular prostration is considera- ble. Cough is short and hacking or in paroxysms; and the sputum, when brought up is rusty and tenacious. Organs not displaced. Dullness on percussion not complete, and the sense of resistance almost nil. EXUDATIVE PLEURISY. Onset moderately sudden, and symptoms not severe — chilliness and pain in the side, followed by cough. Temperature not high, 101.5 or 102 F. Pulse-respiration ratio not disturbed. Face is pale, and there is little loss of muscular power. Cough is dry and painful, and patient tries to re- press it. Organs displaced. Dulness complete, with sense of great resistance. 666 MEDICAL RECORD. ACUTE PNEUMONIA. Respiratory sounds tubular, and fine crepitation heard at border of consolidation. Vocal resonance increased. Vocal fremitus increased. The physical signs are lim- ited to the front or back of the chest. EXUDATIVE PLEURISY. Respiratory sounds much diminished, and friction heard at upper margin of effusion. Vocal resonance greatly di- minished. Vocal fremitus diminished or absent. The physical signs are found both at the back and front of the affected side. 6. See French's "Practice 598 and 602; or Osier's "P page 820. 7- of ILedicine" (1907), pages ractice of Medicine" (1909), ACUTE MILIARY TUBERCULOSIS. Temperature curve is ir- regular. Diarrhea is not common. Roseolar eruption not common. Widal reaction is negative. No typhoid bacilli in blood, urine or feces. Tubercles may be found in the choroid. Pulse and respiration are usually much more rapid. Epistaxis is rare. ENTERIC FEVER. Temperature curve is char- acteristic. Diarrhea is common. Roseolar eruption is gen- erally present. Widal reaction is usually positive. Typhoid bacilli in blood, urine, and feces. No tubercles in the choroid. Pulse and respiration rapid. Epistaxis is common. 8. Symptoms of gastro ptosis: "The patient complains of dyspepsia, abdominal distress and pain after eating, eructations of gases, anorexia, various nervous symptoms, weakness, and constipation. In the standing position the lower part 01 the abdomen projects and the upper part sinks in. In the recumbent position the abdomen shows a lateral extension. Aortic pulsation is frequent. There is often "a ridge lying across the abdomen" to be deter- mined by palpation. Inflation of the stomach often detects its prolapsed position with a lowered gastric splashing. The .r-ray, with the aid of a bismuth subnitrate solution, will determine the location of the oreran." — (Hughes' Prac- tice of Medicine.') 9. See French's "Practice of Medicine" (1907), page 821; or -Osier's "Practice of Medicine" (1909), page 538. 10. See French's "Practice of Medicine" (1907), pages 667 MEDICAL RECORD. 759 and 860; or Osier's "Practice of Medicine" (1909), pages 485 and 577. OBSTETRICS. 1. See Williams' "Obstetrics'' (1909), page 94; or Hirst's "Obstetrics" (1909), page 73. 2. At full term the placenta is a soft, spongy mass, roughly saucer-shaped, from six to nine inches in diameter, about three-quarters of an inch in thickness at the central point, and weighs about one pound. Its functions are : (1) To supply nourishment to the fetus; (2) to act as a respiratory organ for the fetus; (3) to act as an excret- ory organ for the fetus. 3. See Williams' "Obstetrics" (1909), page 194; or Hirst's "Obstetrics" (1909), page 210. 4. The most reliable signs of pregnancy, are: (1) Hear- ing the fetal heart sounds; (2) active movements of the fetus; (3) ballottement ; (4) outlining the fetus in whole or part by palpation ; and (5) hearing the umbilical or funic souffle. VIRGIN UTERUS. The cavity is of normal length — about two and a | half inches, and normal (triangular) in shape. The cervix is small, hard, and cartilaginous, and of the same length as the body. The external os appears as a transverse slit or pinhole orifice with smooth edges. The uterine sound shows that the sides of the cav- ity of the body are con- vex inward. The uterus is normally anteflexed. There is more or less flat- | tening of the anterior and I posterior uterine surfaces. 1 The fundus is nearly flat. The internal os is closed. UTERUS OF MULTIPARA. The cavity is increased in length — three inches or more, and is oval in shape. The cervix is large and soft; it is nearly one inch in length, while the body of the uterus measures nearly two inches. The external os is irregular and its edges are fissured. The sides of the cavity of the body are convex out- ward. The axis of the uterus is apt to be straighter, or the uterus may even be retrodisplaced. The contour of the body of the uterus is more round- ed, while its diameters are increased. The fundus is convex. The internal os is partially patulous. — (From Dorland's Obstetrics.) 668 MEDICAL RECORD. 6. Causes of vomiting in pregnancy, are: (i) Reflex disturbance, due to rapid growth and excessive distention of the uterus; (2) disease or displacement of uterus, tubes and ovaries; (3) disease of pelvis or gastrointes- tinal tract; (4) excessive sexual intercourse; (5) renal disease or disturbance. 7. See Williams' "Obstetrics" (1909), pages 480, etc.; or Hirst's "Obstetrics" (1909), pages 215, etc. 8. See Williams' "Obstetrics" (1909), page 809; or Hirst's "Obstetrics" (1909), page 572. 9. See Williams' "Obstetrics" (1909), pages 174 and 520; or Hirst's "Obstetrics" (1909), page 254. 10. See Williams' "Obstetrics" (1909), pages xii and 190; or Hirst's "Obstetrics" (1909),. pages 13 and 204. GYNECOLOGY. 1. See Cunningham's "Anatomy" (1909), pages 1192 and 1 185 ; or Gray's "Anatomy" (1908), pages 1515 and 1507. 2. Kraurosis valvce is a progressive atrophic shrinking of the tissues of the vulva. 3. Inversion of uterus. Causes: Childbirth and tumors of fundus of uterus. Diagnosis: In the case of polypus the body and fundus of the uterus are in their normal posi- tion in the abdomen, a sound can be passed into the uterus, the uterine and cervical canals are not obliterated, the polypus does not bleed easily, and. is not particularly sen- sible to pain. The inverted uterus shows : Absence of body and fundus from normal position, will not permit passage of a sound into uterine cavity, the uterine and cervical canals are absent, the inverted uterus tends to bleed easily, and is very sensible to pain. 4. Pudendal hematocele. Symptoms: Sharp, tearing pain accompanied by more or less faintness. If the effu- sion is large, it may press on the urethra, causing difficulty in micturition. Causes: Blows, falls, pregnancy, tumors. It frequently occurs after labor, or from strong bearing down after sewing a lacerated perineum, or it may arise from any condition producing or accompanied by a dilata- tion of the vessels about the vulva. 5. Caruncle of the urethra is a small, red, fleshy growth, situated generally on the posterior part of the meatus of the urethra. 6. tuberculous cystitis. 1. Located chiefly about the trigone. 2. Inflammatory reaction zone absent. gonorrheal cystitis. 1. Not at all so confined. 2. Clear inflammatory reac- tion zone, later chang- ing to dull brown color. 660 MEDICAL RECORD TUBERCULOUS CYSTITIS. 3. Local tuberculous cystitis not very common; gen- eral tuberculous cystitis very rare. 4. Characterized by pres- ence of small tubercles situated about the trig- one and ureteral orifices. 5. No projecting tufts of pus. 6. No subperitoneal extra- vasation of blood. 7. Bacillus tuberculosis. 8. Often extension from kidney and from gen- eral tuberculosis. g. History of tuberculosis. Great pain; hematuria. GONORRHEAL CYSTITIS. 3. Of common occurrence both local and general. 4. Characterized early by insular areas of reac- tive inflammation, with healthy or nearly healthy intermediate mucosa. Later insular areas becomes confluent and extend over whole mucosa. 5. Projecting tufts of gon- orrheal pus are apt to be present. In chronic stage regions of eleva- tion may be excavated by ulceration. 6. In very acute stage there is subperitoneal extra- vasation of blood. 7. Gonococcus. 8. Extension from vulva, vagina, or urethra. 9. History of gonorrhea. Less pain ; seldom blood in urine. — (Dudley's Gynecology.) 7. The causes of pelvic peritonitis are infection (generally puerperal) and gonorrhea. 8. Salpingitis is diagnosed by; A dragging sensation in the neighborhood of the affected tube; colicky pain, which is increased on exertion or even on standing; abdominal tenderness ; menstrual disorders, as amenorrhea, metror- rhagia, dysmenorrhea, menorrhagia ; dyspareunia ; there may be septic symptoms and peritonitis; sterility generally ensues. On examination there will be found a fullness in Douglas' pouch and one or both lateral fornices; in these latter will be felt either the tubes, distorted and possibly adherent, or a sausage-shaped tumor, which is very painful; the uterus is retroverted or retroflexed, and may be bound down by adhesions ; there may be an intermittent expul- sion of pus accompanied and preceded by a burning pelvic pain. Tn appendicitis the pain is of sudden onset and is local- 670 MEDICAL RECORD. ized in the right iliac fossa; there is abdominal rigidity, chiefly of the right rectus muscle, and tenderness at Mc- Burney's point; there are usually fever, nausea, vomiting, and constipation. In oophoritis the pain is not localized, but may be bilat- eral, and spreads to the vagina and rectum ; there is no tenderness at McBurney's point; it is usually worse just before the menstrual period, which sometimes affords re- lief ; on vaginal examination the ovary is found to be tender. o. Hydrosalpinx: "The Fallopian tube is distended with serous fluid, which has accumulated therein in consequence of occlusion of the abdominal ostium as the result of a previous attack of salpingitis. The walls are thin, and are usually free from adhesions. The condition may be secon- dary to pyosalpinx. The sac may attain a considerable size (tuboovarian hydrocele). In hydrosalpinx proper the ovary is felt as a distinct body at some spot on the bulging wall of the cyst. This serves to disinguish it from cystic distension of the ovary, in which the ovarian tissue is spread out and cannot be readily identified. In one form of hydrosalpinx the fluid escapes at intervals through the uterine ostium. This condition is described as intermittent hydrosalpinx. It is worthy of note that the uterine end of the Fallopian tube is rarely obliterated in simple sal- pingitis. Hematosalpinx: "This term has hitherto been applied to a condition now recognized to be due to tubal pregnancy. In its present restricted sense it is applied to a distended non-gravid Fallopian tube, containing blood or blood- stained fluid. It is necessary to remember that bleeding from the Fallopian tubes occurs from other causes than tubal pregnancy, and that mere hemorrhage from a tube does not constitute hematosalpinx. Hematosalpinx proper may be due to regurgitation of blood from the uterus, or to exudation from the mucous membrane, as in purpura, scurvy, etc." — (From Aids to Gynecology.) The diagnosis between hydrosalpinx and hematosalpinx is as follows : HYDROSALPINX. i. Walls smooth and elastic. 2. Slower development. 3. Rupture may give relief. HEMATOSALPINX. i. Wall smooth and less elastic. 2. Sudden development. 3. Rupture may cause dan- gerous hemorrhage. — (From Dudley's Gynecology.) 10. Parametritis is inflammation of the connective tissue 671 MEDICAL RECORD. surrounding the uterus, between the folds of the broad ligaments. It is generally associated with some local peritonitis. Causes: "(i) Septic infection after parturi- tion or abortion. (2) Secondary to inflammatory affections of uterus, tubes, or ovaries. (3) Direct injury (lacera- tions) from the use of the uterine sound, caustics, pes- saries, or tents, and after operations. Symptoms: "It is ushered in by a chill, followed by severe intrapelvic pain and tension, constitutional disturb- ance, and fever (ioo° to 102 ). Defecation may be pain- ful, the bowels may be constipated, or there may be un- controllable diarrhea (the latter especially in puerperal cases), with rectal tenesmus. Micturition may be difficult and painful. Nausea, vomiting, and hiccough are com- mon symptoms. If consequent on parturition, the lacteal secretion is arrested, and the lochia cease, or become scanty and fetid, or there may be hemorrhage. The patient lies on the back, with the leg on affected side (or both) drawn up. The mouth is dry; there is thirst and anorexia, and the tongue becomes dry and brown. On examination the vagina is hot, the os uteri is lower than normal, and in post-partum cases it is patulous. It may be deviated from its usual position to the opposite side to that on which the effusion has taken place. The uterus is fixed and im- movable, and the sensation has been likened to that of its being embedded in plaster of Paris, the exudation extend- ing downwards along the vaginal wall. There is much tenderness, and the examination must be conducted with gentleness. The induration may subsequently develop areas of softening indicative of suppuration (pelvic abscess, ab- scess of the broad ligament)." — (From Aids to Gynecol- ogy.) SURGERY. i. An aneurysm is a pulsating sac containing blood, and communicating with the lumen of an artery. 2. A fracture is a sudden solution in the continuity of a bone or cartilage. 3. See Rose and Carless' "Surgery" (1908), page 235; or Da Costa's "Surgery" (1908), pages 250 and 251. 4. See Rose and Carless' "Surgery" (1908), page 521; or Da Costa's "Surgery" (1908), page 506. 5. See Rose and Carless' "Surgery" (1908), page 558; or Da Costa's "Surgery" (1908), page 542. 6. See Rose and Carless' "Surgery" (1908), page 1315; or Da Costa's "Surgery" (1908), page 1221. 7. See Rose and Carless' "Surgery" (1908), page 430; or Da Costa's "Surgery" (1908), page 659. 8. See Rose and Carless' "Surgery" (1908), page 1134; or Da Costa's "Surgery" (1908), page 1009. 672 MEDICAL RECORD. 9. See Rose and Carless' "Surgery" (1908), page 1045; or Da Costa's "Surgery" (1908), page 910. 10. See Rose and Carless' "Surgery" (1908). page 1059: or Da Costa's "Surgery" (1908), page £qt. HYGIENE. 1. *" Among the most common of the diseases and para- s of animals which are communicable to man are: (1) Glanders, a disease of the genus Eqitus, generally fatal when contracted by man; (2) anthrax, a disease of horses, cattle, sheep, and swine, appearing in man either as malig- nant pustule or as internal anthrax, and often fatal; (3) tuberculosis, a disease common in cattle and swine, but also occurring in horses, sheep, goats, dogs, poultry, cage birds, and menagerie animals; (4) rabies, a disease of the genus Can is, communicable to all warm-blooded animals and to man; (5) epizootic aphtha, commonly known as foot-and-mouth disease, a very infectious malady of cattle, sometimes communicated to the consumers of the milk of diseased cattle; (6) Cysticerous bovis, found in cattle, is the larval form of the tapeworm of man known as Tenia saginata; (7) Cysticerous cellulose?, found in swine, is the larval form of the tapeworm of man known as Tccnia solium; (8) the Trichina spiralis, a common parasite of swine, may develop in man and sometimes produces fatal results; (9) the Echinococcus, found in the lungs, liver, and other organs of the meat-producing animals, is the cystic phase of the Tccnia echinococcus of the dog. It is evident that the most satisfactory way of protecting man from this source of danger is to eradicate these dis- eases and parasites so far as possible from the domesticated lals. As complete eradication cannot be accomplished for many years and in some cases not at all, there must be constant efforts for repression and control. People must be made familiar with the dangers; too close asso- ciation with animals should be avoided ; the inspection of meat and of dairy cows should be universal ; swine tlesh should be well cooked; hides, wool, and hair, often in- fected with the anthrax bacillus, should be handled with able precautions: biological products used for the pre- vention or cure of human diseases should be surrounded with everv safeguard to avoid contamination." — (Refer- ence Handbook of the Medical Sciences.) 2. The alimentary principles of food, are: I. Inorganic { ggf ■ IT. Organic Kitrogenous-Proteids.^, itroj 673 Non-Nitrogenous. { Carbohydrates. MEDICAL RECORD. The function (and constituents) are shown in the fol- lowing table, adapted from Notter and Firth's Hygiene: FOOD. Proteids. i. All substances containing nitrogen, of a compo- position identical with, or nearly that of albu- min ; proportion of N to C being nearly as 2 to 7. FUNCTIONS. 2. 3> Substances containing a larger proportion of N are apparently less nu- tritious ; proportion of N to C about 2 to 5J4. Extractive matters, such as are contained in the jurce of the flesh. Carbohydrates. Substances containing no N, but made up of C, H and O ; the O being ex- actly sufficient to con- vert all the H into H 2 0. Fats. Substances containing no N, but made up of C, H and O; the proportion of O being less than sufficient to convert all the H into H 2 0. Salts. Formation and repair of tissues and fluids of the body. Regulation of the absorp- tion and utilization of oxygen. May also form fat and car- bohydrate, and yield en- ergy sometimes. In most foods the above, both animal and vegeta- ble, are largely convert- ed into albumoses and peptones during diges- tion. These perform the above functions less perfectly, or only under particular circumstances. These substances appear es- sentially as regulators of digestion and assimi- lation, especially with reference to the gelatin group. Production of energy and animal heat by oxida- tion. Form fats and possibly some proteids. Supply of fatty tissues, nu- trition of nervous sys- tem; supply of energy, and animal heat by oxi- dation. Support of bony skeleton, supply of HC1 for di- gestion, regulation of energy and nutrition. The objects of cooking, are: (1) To destroy parasites, and so avoid danger of infection ; (2) to break up the starch grains, and so allow the digestive juices to come in contact with the granulose; (3) to loosen the fibers of 674 MEDICAL RECORD. the meats, and so render them more accessible to the digestive juices; also to convert the insoluble collagen into soluble gelatin ; (4) to make the food more palatable, more desirable and more digestible. 3. "The objects of clothing are, aside from motives of decency, to protect the body from the sun's rays in hot weather, from the chilling influence of winds in all weathers, from rain and other forms of wet, and from mechanical and other external injuries and discomforts; to conserve the body temperature and prevent interference with the natural functions of the skin; and, finally, to adorn the persons." — (Harrington's Practical Hygiene.) Cotton is durable, does not shrink, is non-absorbent, and rapidly conducts away heat; hence it soaks up per- spiration and becomes wet, and the moisture being re- evaporated the surface of the body becomes chilled. Linen is much the same, but worse. Wool is a bad conductor of heat, is very absorbent of moisture; so the body is not chilled. Its disadvantages are that it gets hard, shrinks, and may absorb dirt. Silk is a bad conductor of heat, is less absorbent than wool, but more cleanly ; it shrinks less, and is less irritating than wool ; it is expensive and not durable. With regard to color: Black is the most absorbent of heat, and white the least; in between are blue, green, red, and yellow. Heat is reflected most by white, then by yel- low, red, green, blue, and black. The color of underwear is of no consequence. Texture: The looser the texture the more the body heat is preserved. Impermeable materials are very warm, but retain the body moisture and excretions of the skin: they are protective. 4. See French's "Practice of Medicine" (1907), page 309. 5. See French's "Practice of Medicine" (1907), page 5. 6. Typhoid is infectious; Typhus is infectious and con- tagious ; Cholera is infectious ; Scarlet fever is infectious and contagious; Smallpox is infectious and contagious; Yellow fever is infectious. See index to French's or Osier's "Practice," under heading of the various diseases. 7. Both fermentation and putrefaction are forms of de- composition of organic matter under certain favorable con- ditions. Y\ nen the organic matter is composed of carbon, hydrogen, and oxygen only, the process is called fermenta- tion ; when nitrogen and sulphur are also present, putre- faction is said to occur. Y\ nen a substance combines with oxygen the process is called oxidation. 8. Deleterious gases which accumulate in an imperfectly ventilated school room: Carbon dioxide, carbon monoxide, marsh gas, ammonia. Three thousand cubic feet of fresh 675 MEDICAL RECORD. air is required per hour, or 500 cubic feet per minute. Evil effects of inhaling impure air: Heaviness, headache, nausea, listlessness, anemia, chlorosis, loss of appetite and strength ; tendency to phthisis and other lung troubles, and increased liability to acute infectious diseases. 9. Ptomains are basic compounds containing nitrogen. and produced from proteid material by the bacteria which cause putrefaction. They are found in decaying animal tissues and fluids. The chief poisonous ptomains are : Tyrotoxicon, myti- lotoxin, cholin, neurin, neuridin, putrescin, cadaverin, ga- dinin, muscarin, tetanin, typhotoxin. The general symptoms of ptomain poisoning are: Onset in less than twenty-four hours after the ingestion of the noxious "food/' chilliness, vertigo, headache, thrist, ab- dominal pains, nausea, vomiting, diarrhea, cyanosis, weak and rapid pulse, cutaneous eruption sometimes, subnormal temperature at times, convulsions. 10. See French's "Practice of Medicine" (1907), page 781. MEDICAL JURISPRUDENCE. 1. By "last sickness'' is meant the time preceding death when a person is so enfeebled (as the result of disease or accident) that he does not temporarily recover, and which is followed sooner or later by death. The expenses of the last sickness are usually preferred debts, and the med- ical attendant is, so far, a preferred creditor. 2. Human hair may be distinguished from fibers by mi- croscopical examination. The hair will show the medul- lary canal and lateral markings. From hair of other animals: Animal hair is generally thicker, shorter, and coarser than human hair. "In animals the medulla is always present to an appreciable extent, and may occupy sa large a portion of the hair as to leave the cortex very- thin, while in man the medullary substance is much less in proportion, and may be nearly, if not quite, absent. In man the transverse lines are much more marked than in animals." — ( Dwight. ) 3. The most important questions arising in connection with gunshot wounds are: (1) Whether it was suicidal, accidental, or homicidal ; (2) the location of the wound : (3) the distance at which the shot was fired; (4) the wound of entrance and of exit; (5) the deflection of the course of the bullet; (6) the location of the bullet; (7) the position of the individual when shot. 4. Death following burns may be due to : Asphyxia from smoke or other vapors, absence of oxygen, inhalation of flame, fright or injuries, shock, or direct destruction of large part of the body. 676 MEDICAL RECORD 5. To distinguish false from true pregnancy: Examine the patient when she is under the influence of an anesthetic ; the apparent tumor and muscular contractions will dis- appear if it is a case of false pregnancy. 6. It may be very difficult or impossible to distinguish between injuries to the head produced by accident during delivery and those made with criminal intent. In the former case the frontal and parietal bones are commonly affected, on the vertex of the skull is a swelling containing blood, there may be an effusion of blood into the cranial cavity. In the latter case the fracture may affect any bones, it is apt to be greater in extent, and the external signs of violence are greater and more evident. 7. "Age of consent" is the age, fixed by law, under which any carnal knowledge (or attempt at the same) of a female, is rape ; no matter whether she consents or even solicits. 8. "Expectation of life" means the number of years which an individual of a given age, class, and profession. or mode of life may expect to live. 9. "The duties of a coroner are both ministerial and judicial — ministerial, as to become, ex-officio, sheriff when the office of the latter has been vacated ; or to act as a substitute for the sheriff, as when the latter officer is a party himself. The duties, rights, and powers of the sheriff will devolve upon the coroner when he assumes these responsibilities. The judicial authority of the coroner relates to inquiries into the unknown or unexplained causes of sudden or violent death, by a jury of inquest, super visum corporis. He can compel the attendance of wit- nesses, and at the inquest he is fortified with all of the ordinary power of a judicial officer. The common law gives him authority to compel obedience to his subpenas. The authority to .hold inquests extends beyond the terri- torial jurisdiction of the coroner. For example, an in- dividual dies in one county and is buried in another, and if. on account of the suspicious nature of the death, an in- quest becomes necessary, the coroner of the latter county is the proper officer to conduct the proceedings. Besides these duties the coroner is also invested with the further power to inquire of other felonies, of treasure-trove, and of wrecks. In the United States the coroner is elected for a term of several years. The common law does not permit of the appointment of a deputy coroner, though most States in the Union have established statutory pro- visions whereby the coroner has the power to make such appointments. Coroners are excused from serving in offices which might interfere with their duties of coroner, and are further privileged from serving on juries, and from arrest when employed in their official duties. On the other 677 MEDICAL RECORD hand, they are liable to punishment for wilful neglect of duty and for wilful misconduct in the execution of their office; in fact, they may be indicted. At any rate, they make themselves liable to a criminal information for any misconduct in taking an inquisition/' — (Herold's Legal Medicine.^ 10. A wound (medicolegal) is an injury or lesion caused by mechanical or chemical means. The most important questions that arise in connection with wounds are: (i) Was the wound the cause of death directly or indirectly? (2) Was the wound accidental, suicidal, or homicidal, if death results ; and if the patient does not die, was it acci- dental, self-inflicted, or inflicted by another? (3) What was the nature of the instrument by which the wound was caused? (4) Was the wound made before or after death?— (D wight.) STATE BOARD EXAMINATION QUESTIONS. Vermont State Board of Medical Registration. anatomy. 1. Describe the bony pelvis, and state what bounds the cavity of the true pelvis above. 2. Give the anatomy of the hip- joint. 3. Give origin, insertion, nerve supply, and action of the pronator radii teres muscle. 4. Describe the circle of Willis. 5. Describe the peritoneum and its reflections. 6. Bound the axillary space, and name its contents. 7. Describe and bound the fourth ventricle. 8. Describe the prostate gland and give its relations. 9. Describe the male urethra. 10. Name the coverings of femoral hernia. BACTERIOLOGY. 1. Classify bacteria, and name the two most -common pyogenic bacteria. 2. Differentiate the gonococcus from other diplococci. 3. By what culture characteristics may the colon bacillus be distinguished from the typhoid bacillus? 4. Describe the bacillus of Eberth, and give Widal's test for typhoid fever. 5. What bacteria are liable to be mistaken for the tubercle bacillus, and how may this error be avoided? PHYSIOLOGY. 1. Describe ciliated epithelium and (a) state where it is 678 MEDICAL RECORD. found most abundant; (b) what is the function of ciliated epithelium? 2. Name some of the bodily states which lessen the alka- linity of the blood. 3. What is the office of the columnar carneae? 4. What post-mortem tests should be applied to prove that air has entered the lungs of a supposedly stillborn child? 5. Describe (a) the functions, and (b) secretions of the stomach. 6. What is the function in digestion of (a) saliva, (b) bile? 7. How do the products of digestion find their way into the blood? 8. What is the cerebrospinal system of nerves, and to what parts of the body are its fibers chiefly distributed? 9. State where in the human economy the following sub- stances are found : fibrin, mucin, chondrin, leucin, hippuric acid. 10. Name the structures in the body whose functions are doubtful or unknown. HYGIENE. i. Into what general classes are foods divided? Give examples of each. 2. Describe the physiological action of alcohol. 3. What hygienic precautions should be observed by a pregnant woman? 4. If a chemical analysis of water revealed the presence of nitrates and nitrites (a) would this condemn it for drinking purposes? (b) If so, why? 5. Describe the preparation of patient, surgeon, instru- ments, and surroundings for operative procedures. MATERIA MEDICA AND THERAPEUTICS. 1. State properties, action, and preparations of tannic acid. 2. Name four spinal stimulants and state the action of such drugs. 3. Write a prescription for asthma, Basedow's disease, infantile bronchitis. 4. How wouM you proceed if called to see a child (one year) in convulsions? 5. Name three hypnotics, state action of each, and when indicated. 6. Name varieties of expectorants, name three drugs under each, and give dose of same. 7. How would you manage a case of (a) Lobar pneu- monia in an adult? (b) Catarrhal pneumonia in a child (six months) ? 679 MEDICAL RECORD. 8. How would you manage a case of diabetes mellitus ? 9. Give your treatment, prophylactic and medicinal, for a dilated heart. 10. Name three preparations of the following and state incompatibles and indications for same : hydrastis, cinchona, creosote, bromides. 11. Outline the general principles of treatment in a case of poisoning. CHEMISTRY. Answer any five questions. 1. (a) State the physical and chemical properties of O. (b) Mention four methods by which O may be obtained. 2. (a) How many oxides of N are known? Which forms acid? (b) State composition properties and test for car bonic acid. 3. (a) What elements does magnesium resemble? (b) Complete MgC0 3 +H 2 S0 4 . 4. (a) What are alums and state four important ones. (b) Describe and give diagnostic importance of Ehrlich's diazo-reaction. 5 (a) State characteristics of the arsenic group of metals, (b) Show by equations the formation of dibasic acids from monobasic acid, from alcohol. 6. How is urea formed in the body. 7. What is acholia? W r hat is cystin? PATHOLOGY. 1. (a) What are the causes of fever? (b) What are the effects of fever? 2. (a) Mention all the pathological conditions which may produce hemoptysis, (b) The same of hematemesis. 3. Give the pathology of tubercle. 4. Explain the propagation of tapeworm. 5. Mention the different varieties of goiter and give their pathological differences. PRACTICE OF MEDICINE. i. How would you diagnose typhoid fever? 2. Give differential diagnosis between smallpox and chickenpox. 3. Discuss the treatment of pulmonary tuberculosis among the poor. 4. Give treatment for the different pleural effusions. 5. Give treatment for the two commonest of the valvular heart lesions. 6. Discuss prognoses in cerebral embolism and cerebral hemorrhage. 7. Write a short article on epilepsy. 8. Discuss intestinal neuroses. 680 MEDICAL RECORD. 9. How would you manage a case of nervous prostra- tion in a very poor family. 10. What are the comparative urinary findings in the first stages of chronic parenchymatous and chronic inter- stitial nephritis. OBSTETRICS. 1. Describe the changes which occur in the external genitals during pregnancy. 2. Give presumptive signs of pregnancy. Give positive signs. How early during pregnancy would you expect to be able to make a positive diagnosis? 3. Give symptoms and treatment of albuminuria of pregnancy. 4. Describe in detail the preparation of the patient pend- ing labor. 5. How would you resuscitate a child apparently still- born? 6. Give diagnosis and management of a case of occipito- posterior presentation. 7. In a tedious but otherwise normal labor, what are the symptoms which would lead you to interfere? What would you do? 8. Describe the varieties of placenta praevia. To what dangers does the condition expose the mother and child? How would you manage a case? 9. Give symptoms of impending eclampsia. How would you treat a case? What would be your treatment should convulsions ensue? 10. Name the more common pathogenic bacteria that may infect a woman during the puerperium. To what con- ditions may such infection give rise? GYNECOLOGY. 1. Give symptoms of imperforate hymen. How would you manage a case of long-retained discharges due to such conditions? 2. Differentiate simple catarrh from gonorrheal vaginitis. 3. Define rectocele, cystocele, enterocele. 4. Give etiology, symptoms, and treatment of chronic ovaritis. 5. What are the causes of uterine displacements? Which one is of the greatest interest from the obstetrician's stand- point? SURGERY. 1. Name the different tumors of the breast, and describe Halstead's operation for the removal of carcinoma of the breast. 2. Diagnose fistula in ano and describe operation for its cure. 681 MEDICAL RECORD. 3. Give the symptoms of strangulated inguinal hernia. What is taxis? How long should it be continued and how soon abandoned? Describe Bassini's operation for the rad- ical cure of inguinal hernia. 4. Give the etiology, pathology, and symptoms of em- pyema and describe best operation for its cure. 5. Mention the articles you would require in administer- ing ether, the accidents likely to occur, and methods for their relief. 6. Differentiate hernia cerebri from caput succedaneum. Give treatment of the latter. 7. Diagnose fracture of the patella and describe methods of treatment. 8. Describe the various dislocations of the shoulder. Give method for reducing one variety. 9. Give the symptoms and treatment for fracture at the base of the skull. 10. Define osteomalacia and state its significance in surgery. LEGAL MEDICINE. 1. Define the term railway spine. 2. Describe the general characteristics of gunshot wounds. 3. Differentiate paranoia and dementia paralytica. 4. What postmortem appearance would lead you to pro- nounce that death was due to drowning? 5. What is rigor mortis, and tell how it is produced; how long after death does it appear, and when does it disappear? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Vermont State Board of Medical Registration. anatomy. 1. See Cunningham's "Anatomy'' (1909), page 219; or Gray's "Anatomy" (1908), page 209. 2. The hip-joint is an enarthrodial joint, formed by the head of the femur and the acetabulum. The articular sur- faces are covered with cartilage. Near the center of the head of the femur is attached the ligamentum teres. The ligaments are: (1) The capsular, which embraces the margin of the acetabulum above, and the neck of the femur below. (2) The ileo-femoral or Y ligament, which passes obliquely across the front of the joint, and is at- tached above to the anterior inferior spine of the ileum, and bel^w to the anterior intertrochanteric line. (3) The 682 MEDICAL RECORD ligamentum teres. (4) The cotyloid ligament, which deepens the acetabulum, and bridges over the cotyloid notch, being there called (5) the transverse ligament. The joint has a very extensive synoviol membrane. It is ca- pable of the following movements : Flexion, extension, ab- duction, adduction, circumduction, and rotation. 3. Pronator radii teres. Origin: Internal condyle and supracondylar ridge of humerus, and the coronoid process of ulna. Insertion: Middle of outer surface of radius. Nerve supply: Median. Action: Pronation of hand, by rotating radius upon ulna ; also slight flexion of forearm. 4. The Circle of Willis is formed : In front by the two anterior cerebral arteries (branches of the internal caro- tid), which are connected by the anterior communicating artery; behind, by the two posterior cerebrals (branches of the basilar artery), which are connected to the internal carotid on each side by the posterior communicating artery. 5. See Cunningham's "Anatomy" (1909), page 1097; or Gray's "Anatomy" (1908), page 1256. 6. The axillary space is bounded: Anteriorly, by the clavicle, Subclavius, Pectoralis major, costocoracoid mem- brane, Pectoralis minor; posteriorly, by the Subscapularis, Teres major, and Latissimus dorsi; internally, by the first four ribs, first three Intercostal muscles, Serratus magnus; externally, by the humerus, Coracobrachialis, and Biceps. Contents: Axillary vessels; brachial plexus of nerves, and branches; some branches of the upper intercostal nerves ; lymphatic glands, fat, and loose areolar tissue. 7. The fourth ventricle is the expanded portion of the entral canal of the spinal cord; it is a diamond-shaped cavity situated between the cerebellum behind, and the posterior surface of the pons and medulla in front. It is bounded: Above, by the valve of Vieussens and the cerebellum. Below by the pons and medulla. Laterally, by the superior peduncles of the cerebellum, restiform bodies. 8. The prostate gland adjoins the neck of the bladder and surrounds the beginning of the urethra, which is placed nearer the anterior than the posterior surface of the gland. It is said to resemble a horse-chestnut in shape, with the apex directed downwards. It measures about 1^ inches across its base and 1% inches in depth, and 1 inch from before backwards, and is held in position by the anterior true ligaments of the bladder. The gland consists of three lobes, two lateral and one middle, and is perforated from base to apex by the urethra. The common seminal ducts open into the prostatic portion of the urethra, and are placed between the middle and lateral lobes. 683 MEDICAL RECORD. Relations: laterally, anterior or pubic surface. Levator ani. Symphysis pubis. base. Anterior ligaments of blad- Surrounds bladder-neck. der. Vesiculae seminales. Branches of dorsal vein of Vasa deferentia. penis. apex. posterior surface. Rests on upper layer of tri- Rectum. angular ligament. 9. See Cunningham's "Anatomy" (1909), page 1177; or Gray's "Anatomy" (1908), page 1450. 10. The coverings of a femoral hernia, from without in- ward, are : Skin, superficial fascia, cribriform fascia, crural sheath, septum crurale, subserous areolar tissue, and perito- neum. BACTERIOLOGY. 1. Bacteria are classified: (1) Cocci; (2) Bacilli; and (3) Spirilla. Two most common pyogenic bacteria: Staphylococcus pyogenes aureus and Streptococcus pyogenes. 2. The gonococcus is Gram-negative, is found inside the pus cells, and will not grow on the ordinary media, but only on serum. All of these will differentiate it from other diplococci (except the meningococcus, and this latter may be differentiated by its growth on ordinary media). 3. Cultural characteristics that differentiate the colon bacillus and the typhoid bacillus: (1) On gelatin plates the colonies of typhoid develop more slowly than those of :olon bacillus. (2) The colon bacillus causes fermentation with produc- tion of gas in media which contain sugar; the typhoid bacillus does not. (3) The colon bacillus produces a strong acid reaction and coagulates milk within twenty-four to forty-eight hours ; the typhoid bacillus does not coagulate milk. (4) In peptone solution the colon bacillus produces in- dol ; the typhoid bacillus does not. (5) The typhoid bacillus gives the Widal reaction with typhoid serum ; the colon bacillus does not. 4. EbertWs bacillus is a rod-shaped organism, with rounded ends, is from 2 to 4 mikrons in length, and about three-fourths of a mikron in breadth ; it does not stain by Gram's method, but stains with all the anilin dyes; it has flagella, no spores, is aerobic and facultative anaerobic, and is motile. Widal's test: Three drops of blood are taken from the well-washed aseptic finger tip or lobe of the ear, and each lies by itself on a sterile slide, passed through a flame and cooled just before use; this slide may be wrapped in cotton and transported for examination at the laboratory. Here 684 MEDICAL RECORD. one drop is mixed with a large drop of sterile water, to re- dissolve it. A drop from the summit of this is then mixed with six drops of fresh broth culture of the bacillus (not over twenty-four hours old) on a sterile slide. From this a small drop of mingled culture and blood is placed in the middle of a sterile cover-glass, and this is inverted over a sterile hollow-ground slide and examined. A positive re- action is obtained when all the bacilli present gather in one or two masses or clumps, and cease their rapid movements inside of twenty minutes. 5. The bacteria liable to be mistaken for the tubercle bacillus are : The bacillus of leprosy, the bacillus of the smegma, and Lustgarten's bacillus. "The differential diag- nosis between these four organisms depends upon the fol- lowing reactions : When stained by the carbol-fuchsin method, commonly employed in staining the tubercle bacil- lus, the Lustgarten's bacillus becomes almost instantly de- colorized by treatment with mineral acids, particularly sul- phuric acid ; whereas the smegma bacillus resists such treatment for a much longer time, and the lepra and tuber- cle bacillus for a still longer time. On the other hand, ii decolorization is practised with alcohol instead of acids, the smegma bacillus is the first to lose color. The bacillus tuberculosis and the bacillus of leprosy are both very re- tentive of their color, even after treatment with acids and alcohol. If, then, we treat the preparation, stained with carbol-fuchsin, with sulphuric acid, Lustgarten's bacillus be- comes almost at once decolorized. If it is not immediately decolorized, heat with alcohol ; if it is then decolorized, it is the smegma bacillus. If it is still not decolorized, it is either the leprosy or the tubercle bacillus/' — (From Park's Pathogenic Bacteria.) PHYSIOLOGY. 1. Ciliated epithelium generally consists of columnar epithelial cells surmounted by fine, tapering filaments or cilia ; these latter move to and fro, and produce a current. (a) They are found in the upper air passages, Fallopian tubes, ventricles of the brain, central canal of the spinal cord, vasa efferentia, and the tail of the spermotozoon. (b) Functions: To keep foreign particles out of the respiratory tract, to assist the ovum in the Fallopian tube onwards to the uterus, to enable the spermatozoa to pro- gress ; generally — protection and motion. 2. The alkalinity of the blood is lessened by: Muscular exertion, anemia, uremia, high fever, diabetes, and rheu- matism. 3. The office of the Columnce carnece is: To prevent too great dictation of the ventricles, to regulate their contrac- tion, and to prevent the auriculo-ventricular valves from being turned into the auricles. 68=; MEDICAL RECORD. 4. The hydrostatic test: "For the purpose of these tests the lungs, heart, pericardium, and thymus should be re- moved in mass and placed in a vessel containing water several inches in depth, and the height to which the whole mass floats noted. In thoroughly distended lungs there will be sufficient buoyancy to float the entire mass, includ- ing the heart and thymus. In purely fetal lungs the whole mass will sink to the bottom. They are then held under water, and with a sharp knife incisions are made into various portions of the lung substance. If air or gas is present small bubbles will be seen arising from the cut surface through the water. The lungs are then detached from the other organs and their buoyancy noted. In case of fetal lungs they will still sink to the bottom. If the buoyancy be not sufficient to float all of the organs in mass, it may be just enough to float the lungs by themselves. The lungs are then cut with scissors into small frag- ments, perhaps one-half inch in diameter, and the buoy- ancy of the separate fragments is noted. Those portions which contain gas or air will now float; while if any pieces are present which are in the fetal condition they will sink. Those portions which have floated are then col- lected in a towel or other cloth and a considerable amount of pressure applied to them as by treading, in order to see whether it is possible to express by this pressure the gas or air which is contained in them, and they are placed again in water. If they float now, it has been proved that air or gas has thoroughly permeated the small bronchi and air vessels." — (D wight's Medical Jurisprudence.) 5. Stomach, (a) Functions: To receive the food, to secrete gastric juice, to mix the gastric juice with the food, to digest the proteids, and to absorb such portion of the food as is ready for absorption. (b) Secretions: The gastric juice. This is a thin, color- less fluid, acid in reaction owing to the presence of hydro- chloric acid, specific gravity 1001 to 1010, and contains about 1 per cent, of solids (pepsin, hydrochloric acid, a curdling ferment, mucin, and salts). 6. The saliva (by its ptyalin) converts starches into dextrose. The bile assists in emulsifying and saponifying fats, and also in the absorption of fats; it also aids the pancreatic secretion. 7. The products of digestion find their way into the blood by two routes: (1) By the blood vessels of the gastrointestinal tract, which unite to form the portal vein, and (2) by the lymph vessels of the small intestine, which converge to empty into the thoracic duct. The water, inorganic salts, proteids, and sugar go by way of the portal vein to the ascending vena cava; the fats go by way of the 686 MEDICAL RECORD. thoracic duct to the junction of the left subclavian and internal jugular veins. 8. The cerebrospinal system of nerves consists of the brain, spinal cord, and all the nerves connected with the brain and spinal cord; i.e. all except the sympathetic nervous system. Its fibers are distributed to the voluntary muscles, the organs of special sense, and the parts endowed with sensibility. 9. Fibrin is found in the blood and lymph; mucin, in saliva and syuovial fluid; chondrin, in bone and cartilage; leucin, in the pancreas and spleen; hippuric acid, in the urine. 10. Structures of doubtful or unknown function: Spleen, thyroid, thymus, parathyroids, suprarenals, pituitary body, carotid and coccygeal glands. HYGIENE. i. Foods are divided into: I. Inorganic. / Water. * Salts. Non-nitrogenous, < Carbohydrates. II. Organic. \ { Fats. ( Nitrogenous — Proteids. Example of each : Carbohydrate, sugar ; Fat, fat of meat; Proteid, flesh of animals; Salt, sodium of chloride. 2. Physiological action of alcohol. Nervous system: Alcohol is first a powerful excitant, afterward a depres- sant ; it increases the reflex activity of spinal cord, muscles, and nerves; in large doses it produces lack of co-ordina- tion. Circulatory system: It stimulates the heart muscle and increases the rapidity and force of the heart beat; there is a rise of arterial pressure. Respiration is stimu- lated by small doses, and decreased by large ones. Tem- perature: Alcohol produces a sensation of warmth, and warms the extremities by causing the heart to pump hot blood from the center of the body to the cold parts. If used in excess the temperature rapidly falls, owing to in- crease of heat radiation and to depression of vital power. Bodily metabolism: Elimination of C0 2 is generally in- creased ; the effect on absorption of O is not known. It adds force but not tissue to the body. Elimination: It is largely burnt up in the body, but in excessive doses it is eliminated by the breath, skin, kidneys, and intestines. Digestion is aided by moderate doses, but is disordered by large amounts. (From Hare's Therapeutics.) 3. See Williams' "Obstetrics" (1909), page 199; or Hirst's "Obstetrics'' (1909), page 188. 4. Nitrates are generally due to the oxidation of organic matter of animal origin. 687 MEDICAL RECORD. Nitrites generally indicate sewage contamination. The presence of nitrites should condemn the water; so should a marked amount of nitrates. 5. See Rose and Carless' "Surgery" (1908), page 264; or Da Costa's "Surgery" (1908), page 50. MATERIA MEDICA AND THERAPEUTICS. i. Tannic acid. Properties: A light amorphous powder, with slight odor and astringent taste; it gets darker on exposure to air and light. Action: Astringent and hemostatic; it will precipitate albumins ; it is an antidote to antimony and some alkaloids. Preparations: Glycerite of tannic acid, ointment of tannic acid, troches of tannic acid, and styptic collodion. 2. Four spinal stimulants: Strychnine, brucine, ammonia, and thebaine. The action: They increase the irritability of the anterior cornua of the spinal cord. 3. For asthma: ]$. Sodii iodidi. Tincturae belladonnas foliorum. Tincturse hyoscyami. Tincturas lobeliae, aa 3ij. Syrupi pruni virginianse, q.s. ad Jiij. M. Signa: Take one teaspoonful, in water, four times a day. For Basedow's disease: #. Extracti opii, gr. v. Extracti belladonnas foliorum, gr. iv. Extracti ergotas, 3jss. M. Fiat massa in pilulas no. xx dividenda. Signa : Take one pill after each meal. For infantile bronchitis: #. Antimonii et potassii tartratis, gr. J^. Pulveris ipecacuanhas, gr. J4. Ammonii chloridi, gr. v. M. Ft. in chart, no. xx. Signa: Take one every two hours (eight in twenty- four hours). 4. See French's "Practice of Medicine" (1907), P a & e 1 124; or Osier's "Practice of Medicine" (1909), page 1058. 5. Three important hypnotics: (1) Chloral hydrate; (2) Sulphonal; (3) Trional. Indications: They are all used to produce sleep (when no pain is present). Chloral hydrate produces a natural sleep, acts promptly, but is of no service if pain is present; it also lowers the body temperature. It can be given for a long time without deleterious effect, but it may irritate the tissues and weaken the heart. 688 MEDICAL RECORD. Sulphonal produces a natural sleep, but is of slow action, requiring three or four hours to take effect ; it is of no use if pain is present, does not irritate the tissues and weaken the heart, but is probably not so good for continuous use as chloral hydrate, though the two may replace each other for a time. Trional is very similar to sulphonal, but is more soluble, and acts quicker. Both sulphonal and trional are supposed to be safer than chloral. 6. Expectorants are classified as : (i) Xauseating or Sedative, as Tartar emetic, dose gr. y 2 ; apomorphine hydrochloride, dose % ; and ipecac, dose TT£xx (of the fluid extract). (2) Stimulating, as Ammonium chloride, dose gr. viij ; balsam of Tolu, dose gr. xx; senega, dose gr. xv. 7. See French's "Practice of Medicine" (1907), pages 174 and 674; or Osier's "Practice of Medicine" (1909). pages 189 and 626. 8. See French's "Practice of Medicine" (1907), page 944; or Osier's "Practice of Medicine" (1909), page 420. 9. See French's "Practice of Medicine" (1907), page 602; or Osier's "Practice of Medicine" (1909), page 828. 10. Hydrastis. Three preparations: Fluidextract, tinc- ture, and glycerite. Incompatibles: Alkalies, mineral acids, tannic acid, and other vegetable acids. Indications: Non- acute inflammations of mucous membranes, catarrh of stomach or intestines, dysmenorrhea, menorrhagia. intes- tinal indigestion. Cinchona. Three preparations: Quinine sulphate, bisul- phate, and hydrobromide. Incompatibles: Tannic acid, alkalies, alkaline earths, iodine. Indications: Malaria, hay fever, whooping cough, chronic cystitis, digestive dis- turbances. Creosote. Preparation: The water is the only oflicial preparation. Incompatibles: Sulphuric and nitric acids, sil- ver salts. Indications: As an antipruritic, phthisis, chronic bronchitis, congestion of trachea or larynx. Bromides. Preparations: Potassium, sodium, ammo- nium, lithium, calcium, zinc, and strontium bromides ; di- luted hydrobromic acid and bromoform. Incompatibles: Acids, acid salts, metallic salts (spirit of nitrous ether is incompatible with ammonium bromide). Indications: Epi- lepsy, insomnia, nervousness, neuralgia, hysteria, migraine, delirium tremens, sea-sickness. 11. General principles of treatment in poisoning: "(1) Lose no time. (2) Use the best remedy obtainable at once. (3) Get rid of the poison. (4) Stop its action. (5) Remedy the mischief already done. (6) Fight against the tendency to death (Tanner). In the treatment of 689 MEDICAL RECORD. poisoning, whether by mineral or vegetable substances, if the poison is known the first indication is to administer the proper chemical antidote, so as to render it harmless or comparatively so. Next, the stomach should be emptied and washed out, lest the newly formed compound be ab- sorbed after a time, also to remove any poison which may have escaped the action of the antidote. Next, the ap- propriate antagonist should be administered to counteract the effects of such portion of the poison as may have been absorbed. Lastly, such antagonistic measures should ^ be employed as may sustain the action of any organic function showing signs of failure. In most cases of alkaloid poison- ing absorption has proceeded so far before professional assistance is obtained that antidotes are of no value, hence reliance can be placed only upon the physiological antagon- ist and such supporting measures as will tend to maintain vitality until the poison can be eliminated by the natural channels. "—(Potter's Materia Medica, etc.) CHEMISTRY. I. Oxygen. Properties: Oxygen is a colorless, odorless, tasteless gas, slightly soluble in water, heavier than air. It has a strong tendency to combine with other elements, and forms binary compounds with all elements except fluorine and bromine. Oxygen is necessary to the processes of life and combustion. Preparation: (i) By heating potassium chlorate: 2KC10 3 =:2KCl + 30 2 (2) By heating manganese dioxide: 3Mn0 2 = Mn 8 0* + O a (3) By the action of sulphuric acid on manganese dioxide : 2Mn0 2 + 2H 2 S04 = 2MnS0* + 2H a O + 2 (4) By the action of water upon sodium dioxide : 2Na 2 O a + 2H 2 = 4NaHO + 2 2 (a) There are five oxides of nitrogen known : Nitro- gen monoxide, N 2 ; nitrogen dioxide, N a 2 , or NO ; nitro- gen trioxide, N 2 3 ; nitrogen tetroxide, N a 4 , and nitrogen pentoxide, N2O5. Of these, the trioxide and the pentoxide form acids. (b) Carbonic acid, formula H 2 COs, does not exist free, but is decomposed as soon as liberated into C0 2 and H 2 0. Carbon dioxide, CO a , is often (improperly) called car- bonic acid ; but this could hardly happen on an examination paper in chemistry. 3. Magnesium resembles zinc and cadium : MgCOa + H.SO* = MgSO* + CO. + H a O 4. (a) Alums are double sulphates of the alkaline metals and the aluminum or iron group. Four important alums: Aluminum potassium sulphate; 690 MEDICAL RECORD aluminum ammonium sulphate; ferric sodium sulphate, and chromic ammonium sulphate. (b) For Ehrlich's diazo reaction two solutions are re- quired: (i) A saturated solution of sulphanilic acid in a mixture of 50 c.c. of hydrochloric acid and 950 c.c. of water, and (2) a 0.5 per cent, solution of sodium nitrite. To make the test, 1 c.c. of (2) is added to 40 c.c. of (1), and the mixture thoroughly shaken. Equal quantities of this mixture and the urine to be tested are shaken to- gether in a test tube, and 1 c.c. of ammonia is then floated upon the surface, when, in an affirmative result, a red band is formed at the junction of the fluids. Its diagnostic value is uncertain. Von Jaksch "disclaims tor this test any clinical _ importance whatever." Others have claimed that the reaction is pathognomonic of typhoid, but it has been found in other diseases besides typhoid — namely, phthisis, pneumonia, measles, scarlet fever, small- pox and malaria. 5. (a) The answer to this question will depend upon the text book used by the student (or examiner). Witthaus puts arsenic in the same group with nitrogen, phosphorus, and antimony; Remsen, in the same group with nitrogen, phosphorus, antimony, and bismuth; Simon, in the same group with antimony, tin, gold, platinum, and molybdenum ; Holland, in the same group with antimony and tin. According to the first of these groupings the arsenic group is trivalent or quinquivalent; with hydrogen non- acid compounds are formed, composed of one atom of the element in the gaseous state with three atoms of hydrogen ; two oxides are formed, the trioxide and the pentoxide ; they are poisonous. (b) 2CR2 Br. COOH + Ag 2 — 2AgBr + C 2 H 4 (COOH) 2 (Bromacetic acid) (Succinic acid) CH 2 OH. CH 2 OH + 2O2 = 2H 2 + COOH. COOH (Ethene glycol) - (Oxalic acid) 6. Urea is the end product of the proteid metabolism of the body. This metabolism is chiefly carried on in the muscles. It is not known in what form nitrogen leaves the muscles, but it is believed that the final products of muscle metabolism are ammonia and sarcolactic acid. Hence it is probable that nitrogen leaves the muscles as ammonium lactate. The tissues convert combinations of organic acids and ammonia into carbonates; these are dehydrated in the liver, so that ammonium carbonate becomes ammonium carbamate, and this by further dehydration becomes urea. The following formulae show this relationship, and how the loss of one molecule of water converts ammonium car- bonate into carbamate, and the loss of a second molecule of water produces urea : 691 MEDICAL RECORD. rn /O.NH4 rn /NH 2 m/ NH ^ NH 4 Carbonate. NH 4 Carbamate. Urea. 7. Acholia is absence of the secretion of bile. Cystin is (chemically) diamido-beta-dithio-dilactic acid. It is found in urinary sediments and calculi. PATHOLOGY. 1. (a) Causes of fever: Disturbance of the heat-regulat- ing centers, either directly or by toxic substances circulating in the blood. These latter may come from bacteria, or may be due to disordered metabolism, or to chemical or mechanical injury of the tissues. (b) Effects of fever: Loss of appetite, thirst, emacia- tion, disturbance of function, the alkalinity of the blood is lessened; degenerative changes such as cloudy swelling, fatty degeneration, and coagulation necrosis may occur in the tissues, particularly in the heart, liver, kidneys, and muscles. 2. (a) The causes of Hemoptysis: Traumatism; certain organic diseases of the lung, especially tuberculosis, lobar pneumonia, bronchiectasis, gangrene, infarct, and cancer. Passive congestion, the result of heart disease, especially mitral lesions ; rupture of aortic aneurysm ; diseases pro- foundly affecting the blood, such as purpura, hemophilia, scurvy, and leukemia; ulcers, traumatic, syphilitic, or ma- lignant of the trachea or larynx; and vicarious menstrua- tion (very rare). (b) The causes of Hematemesis: Traumatism; gastric ulcer; gastric cancer; venous engorgement of the stomach following cirrhosis of the liver, primary splenomegaly, or chronic heart disease; acute gastritis; blood dyscrasia, as in scurvy, purpura, severe infections, and grave anemias ; rupture of aneurysm; swallowing of blood from nose, mouth, or throat; vicarious menstruation; hysteria. — (From Steven's Practice.) 3. See Rose and Carless' ''Surgery" (1908), page 166; or Da Costa's "Surgery" (1908), page 213. 4. See French's "Practice of Medicine" (1907), page 473. 5. See French's "Practice of Medicine" (1907), page 546; or Osier's "Practice of Medicine" (1909), page 763. PRACTICE OF MEDICINE. i. See French's "Practice of Medicine" (1907), page 101 ; or Osier's "Practice of Medicine" U909), page 93. 2. (1) Very young children are attacked with varicella, whereas variola usually shows itself in adults. (2) Vac- cinated children readily take varicella ; not so variola, even in the modified form. (3) Children who have had varicella may contract variola, even soon afterwards; or the two 692 MEDICAL RECORD. diseases may coexist. (4) Varicella is noninoculable, whereas variola is notoriously so. (5) The eruption of varicella appears in twenty-four hours; that of variola not till the third day. (6) The febrile symptoms continue after the eruption appears in varicella; those of variola subside. (7) In varicella the spots come out in successive crops; this is never seen in variola. (8) The spots in varicella are unilocular, and collapse on being punctured; the spots in variola are multilocular, and do not collapse on being punctured. (9) In varicella the eruption is very irregular, and appears over the body generally; in variola it appears in groups of threes and fives, and is always seen on the limbs; (10) The papule in varicella is soft, and disappears on stretching the skin ; in variola it is hard and shotty, and does not disappear on stretching the skin. — (From J. W. Moore's work on Variola and Varicella.) 3. See French's ''Practice of Medicine" (1907), page 391; or Osier's "Practice of Medicine" (1909), page 352. 4. See French's ''Practice of Medicine" (1907), page 699; or Osier's "Practice of Medicine" (1909), page 653. 5. See French's "Practice of Medicine" (1907), page 592; or Osier's "Practice of Medicine" (1909), page 816. 6. See French's "Practice of Medicine" (1907), pages 1076 and 1082; or Osier's "Practice of Medicine" (1909), page 9/6. 7. See French's "Practice of Medicine" (1907), page 1125; or Osier's "Practice of Medicine" (1909), page 1058. 8. See French's "Practice of Medicine" (1907), page -78. 9. See French's "Practice of Medicine" (1907), page 1 150; or Osier's "Practice of Medicine" (1909), page 1093. 10. See French's "Practice of Medicine" (1907), pages 899 and 903; or Osier's "Practice of Medicine" (1909). pages 693 and 697. , OBSTETRICS. 1. See Williams' "Obstetrics" (1909), page 169; or Hirst's "Obstetrics" (1909), page 185. 2. Presumptive signs of pregnancy: (1) Progressive en- largement of the uterus; (2) Hegar's sign; (3) Braxton Hick's sign; (4) uterine murmur; (5) cessation of men- struation; (6) changes in the breasts; (7) discoloration of the vagina and cervix; (8) pigmentation and striae: (9) morning sickness. Positive signs of pregnancy: (1) Hearing the fetal heart sound; (2) active movements of the fetus; (3) ballotte- ment; (4) outlining the fetus in whole or part by palpa- tion; and (5) the umbilical or funic souffle. A "positive diagnosis can very rarely be made before the 693 MEDICAL RECORD. sixteenth week; often not till the eighteenth or twentieth week. 3. See Williams' "Obstetrics" (1909), pages 520 and 172; or Hirst's "Obstetrics" (1909), page 253. 4. See Williams' "Obstetrics" (1909), page 303; or Hirst's "Obstetrics" (1909), page 326. 5. See Williams' "Obstetrics" (1909), page 846; or Hirst's ''Obstetrics" (1909), page 939. 6. A diagnosis of occipito-posterior position may be based on : Finding the sagittal suture in the oblique diameter of the pelvis, the posterior fontanelle in the posterior half of the pelvis, the anterior fontanelle is easily accessible; the fetal heart sounds are heard far back in the flank, between the ribs and the crest of the ilium ; the fetal head may be felt above the pelvic brim, and the fetal small parts are felt through the anterior abdominal walls of the mother, while the fetal back is not felt. Management: See Williams' "Obstetrics" (1909), page 267; or Hirst's "Obstetrics" (1909), page 407. 7. See Williams' "Obstetrics" (1909), page 658; or Hirst's "Obstetrics" (1909), page 439. 8. See Williams' "Obstetrics" (1909), page 809; or Hirst's "Obstetrics" (1909), page 572. 9. The danger signals of impending eclampsia are : Head- ache ; tinnitus aurium ; dizziness ; pain over stomach ; diges- tive, visual, and nervous disturbances; general debility; insomnia, vomiting, and vertigo. For preventive treatment: (1) The amount of nitrogenous food should be diminished to a minimum; (2) the production and absorption of poisonous materials in the intestines and body tissues should be limited and their elimination should be aided by improving the action of the bowels, the kidneys, the liver, the skin, and the lungs; (3) the source of the fetal metabolic products and the peripheral irritation ^ in the uterus should, if necessary, be removed by evacuating that organ. The curative treatment includes: (1) Controlling the convulsions (by chloroform, veratrum, or chloral) ; (2) elimination of the poison or poisons which are presumed to cause the convulsions ; (3) emptying the uterus under deep anesthesia, by some method that is rapid and that will cause as little injury to the woman as possible. 10. See Williams' "Obstetrics" (1909), page 857; or Hirst's "Obstetrics" (1909), page 725. GYNECOLOGY. 1. Imperforate hymen. Symptoms: Non-appearance of menstruation ; presence of a bulging tumor in perineum, extending to vagina and uterus ; severe pain at menstrual period. Treatment : Conical incision, edges of which should 694 MEDICAL RECORD. be united by a running catgut suture; followed by anti- septic douche. 2. Gonorrheal vaginitis is diagnosed by the finding of the gonococci in the discharge. 3. Cystocele is a hernia of part of the bladder into the vagina, covered by the mucous membrane of the anterior vaginal wall. Rectocele is a hernia of the rectum into the vagina, covered by the mucous membrane of the posterior vaginal wall. The two conditions are generally found to- gether. Enterocele is a hernia of the small intestine. 4. Chronic ovaritis. Etiology: Continuance of the acute form. Excessive or violent sexual intercourse. Masturba- tion. Suppressed menstruation. Operations upon the cer- vix. Symptoms: A constant dragging pain, increased be- fore menstruation, particularly on motion, riding, or mak- ing a misstep. The pain is greatest over the affected ovary, but radiates to the lumbar region, along the spine, down the thighs, and frequently in one or both mammary glands. Headache is an almost constant symptom. Pain- ful micturition, defecation, and sexual intercourse usually appear also as symptoms. The menstruation is increased, amounting to menorrhagia. Hysteria or hysteroepilepsy is not uncommon. When both ovaries are diseased sterility occurs. Treatment: Rest in bed, particularly during the menstrual periods. Abstinence from sexual intercourse. Copious vaginal injections of hot water twice daily are of service in reducing congestion, and to further aid in this object the cervix and vaginal vault should be painted with iodine twice or thrice a week. Leeches may be ap- plied to the abdomen over the affected ovary or to the cervix, if pain is great. Blisters over the ovaries or mer- curial inunctions frequently do good. Internally, the ad- ministration of iodid or chlorate of potassium or the bromids are of service. — (From Wells* Compend of Gyne- cology.) 5. Uterine displacements may be due to: Relaxation of uterine ligaments ; increased weight of fundus ; subinvolu- tion ; ovarian or other tumor pressing on uterus ; distended bladder ; peritonitis or cystitis ; prolonged dorsal decubitus ; tight bandaging in the puerperium. Tight lacing and tight clothine: congenital conditions; metritis and parametritis with adhesions ; atonic conditions of the uterus following labor, and errors of development. Retroversion and retro- flexion are of the greatest obstetrical interest. surgery. 1. See Rose and Carless' "Surgery" (1908), pages 945 and 956: or Da Costa's "Surgery" (1908), pages 1231 and 1236.* 095 MEDICAL RECORD. 2. See Rose and Carless' "Surgery" (1908), page 1134; or Da Costa's "Surgery" (1908), page 1009. 3. See Rose and Carless' "Surgery" (1908), pages 1096, 1099, 1 100, and 1 081 ; or Da Costa's "Surgery" (1908), pages 992, 995, and 978. 4. Empyema. Etiology : Wounds, injuries, pleuropneu- monia, direct extension of a suppurative process in the lung, abdomen, or neck. The bacteria will vary with the cause; Diplococc'us pneumonia is the commonest; tubercle bacillus, staphylococcus, streptococcus, Colon bacillus may also be present. Pathology: The organisms causing it are pneumococci, streptococci, staphylococci, tubercle bacilli, Bacillus coli t and actinomycosis. The physical signs are those of fluid in the pleural cavity; that side does not move well, the percussion note is dull, there is absence of breath sounds, vocal fremitus and reso- nance are diminished. Left alone, an empyema may burst through an intercostal space, usually the fifth. The lung is collapsed in extent according to the amount of pus. The pleura, at first covered with lymph, soon becomes covered with layers of granulation tissue, the deeper part of which is converted into fibrocicatricial tissue, and the lung itself also undergoes some fibroid change. If the pus is let out early the lung and pleura soon expand, but if allowed to go on the infiltration of the lung and the density of the scar tissue covering it hinder expansion. Nature attempts to remedy this in various ways. (1) The other lung ex- pands and pushes the heart over to the opposite side; (2) the chest wall falls in, the intercostal spaces are obliterated, and the spine is curved, with its concavity toward that side; (3) the abdominal viscera are pushed up; and (4) exuberant granulations form on the pleura. If a cavity still remains an operation is necessary. Symptoms: Fever, sweats, chill, diminished breath sounds and vocal fremitus, impaired mobility of chest, dullness on affected side, heart displaced to opposite side, leucocytosis. Treatment: Aspiration, drainage, irrigation, resection of ribs (Estlander's operation), or resection of chest wall (Schede's operation). 5. See Rose and Carless' "Surgery" (1908), pages 1323, etc.; or Da Costa's "Surgery" (1908), pages 1031 and 1034. 6. See Rose and Carless' "Surgery" (1908), page 791; and Da Costa's "Surgery" (1908), page 690. 7. See Rose and Carless' "Surgery" (1908), page 550; or Da Costa's "Surgery" (1908), page 533. 8. The various dislocations of the shoulder joint are: (1) Subcoracoid — forward, inward, and downward. (2) Subglenoid — downward, forward, and inward. (3) Sub- 696 MEDICAL RECORD. spinous — backward, inward, and downward. (4) Subclav- icular — forward, inward, and upward. The special diagnostic signs are: (1) Subcoracoid: The head of the humerus is felt below the outer end of the clavicle ; there is little or no shortening of the limb ; the elbow is directed outward and backward. (2) Subglenoid: The head of the humerus can be felt in the axilla ; the arm is decidedly lengthened ; the elbow is flexed, and there are signs of pressure on vessels and nerves (3) Subspinous : The head of the humerus is felt below the acromion process and behind; the arm is rotated in- ward, and the elbow is displaced outward. (4) Subclavicular: The head of the humerus is felt below the clavicle; the elbow is far from the side, and the limb may be shortened. Kocher's method of reduction is : to flex the forearm, press the elbow to the side, rotate the arm outward. Bring the arm forward and upward to a right angle with the body, then rotate inward, while the elbow is brought down over the body so that the fingers sweep the opposite shoulder. 9. See Rose and Carless ? "Surgery" (1908), page 745; or Da Costa's "Surgery" (1908), page 709. 10. Osteomalacia consists in a softening of the bone tis- sues; it is found in the fully formed adult bones; there is great possibility of bending or fracture of bones, with con- siderable deformity. It may prove a serious obstacle to parturition. LEGAL MEDICINE. i. Railway spine is defined as "the series of nervous symptoms developed from shock produced by a railway accident, or from the concussion produced by constant travel." 2. Gunshot wounds "differ from ordinary punctured and penetrating wounds in that the tissues immediately sur- rounding the canal through which the projectile passed are so contused and injured as to result in their death. For this reason the canal resulting from a gunshot wound does not heal by first intention, and is particularly liable to infection and sloughing. Gunshot wounds, on account of the velocity of the projectile and the degree of propelling force, are associated with a greater amount of shock than would result from the same wound from other causes." — (Dwight's Medical Jurisprudence.) 3. Paranoia "is a form of insanity which comes espe- cially under the class of degenerative diseases. It is essen- tially characterized by a delusion or delusions of a fixed and "systematized character. They are usually indeed of 697 MEDICAL RECORD one kind, and the disease has perhaps for this reason been called monomania. This is, however, an unfortunate term, as we find this symptom not infrequently in other forms oi insanity, as melancholia, where we always observe de- cidedly fixed ideas of depression. The main fundamental characteristic of this disease is a delusion which has be- come a part of the belief of the individual, and which he believes himself able to explain and defend." — (Witthaus and Becker's Medical Jurisprudence, etc.) For dementia paralytica see French's "Practice of Medi- cine'' f-mn7), page 1092. 4. There will be the signs of death from asphyxiation, viz. : The right side of the heart and the venous system full of blood ; congestion of the mucous membrane of the bronchial tubes ; the sinuses of the brain are filled with blood; the brain, liver, spleen, and kidneys will be congested; the blood is usually dark colored. 5. Rigor mortis is the condition of rigidity or contraction into which the muscles of the body pass after death. It begins at a period varying from about fifteen minutes to about six hours. It usually begins in the muscles of the eye, neck, and jaw ; then the muscles of the chest and upper extremity, and last of all those of the abdomen and lower extremity are affected. It passes off in the same order in about twenty- four hours. It is said to be due to the coagulation of the muscle plasma. STATE BOARD EXAMINATION QUESTIONS. Medical Examining Board of Virginia. anatomy and embryology. 1. Describe briefly the nasal cavity and the bones which enter into its formation. 2. Describe the sacrum and tell what passes through the openings in it. 3. (a) What membranes envelop the brain? (b) What processes are formed by the outer one? 4. Name the bones which form the foot, and give the articulation of each. 5. Give the course and relations of the ureter in the female pelvis. 6. What nerves supply the tongue? 7. Name the muscles attached to the scapula. 8. Describe the abdominal aorta. Name its branches and give their general distribution. 9. Give boundaries and contents of Scarpa's triangle. 10. Give the course and relations of the colon. 698 MEDICAL RECORD. PHYSIOLOGY. i. Describe the digestive processes which take place in the mouth and stomach. 2. What changes take place in the blood in its passage through the lungs? What is tidal air and residual air? 3. Which portion of the glandular structure of the kidney excretes the salts, and which the watery constituent of the urine? Describe normal urine. 4. What nerves form the solar plexus, and what organs (viscera) does it supply? 5. Give the origin, function, and distribution of the seventh cranial nerve. 6. Name the varieties and respective functions of the glands of the skin. Where is the breathing center located? MATERIA MEDICA. i. Name the preparations of manganese. Give dose and physiological action of each preparation. 2. Describe the physiological effects of emetine. 3. Compare the effects of hyoscyamus, belladonna, and stramonium. 4. Describe the toxic action of and give the antidotes to the salts of mercury. 5. What is ergot? What are its effects upon the partu- rient uterus? Give dose of the fluid extract. 6. Name the principal alkaloids of opium. Compare their effects and give the antagonists to opium poisoning. CHEMISTRY. 1. Describe iodine. From what source is it chiefly ob- tained? What are its uses? Give a simple test for iodine. 2. What elements are known as the alkali-metals? Give some of their common properties. 3. Give formulae of three official potassium salts, indicat- ing the uses of each. 4. To what does potassium permanganate owe its disin- fectant properties? Explain this reaction. 5. Give the formulae of mercurous chloride and mercuric chloride. Describe the difference between them as regards their physical appearance and medicinal properties and uses. 6. Give formula of chloral hydrate. How is it prepared ? Give uses. TOXICOLOGY. 1. Give symptoms and treatment of acute arsenical poisoning. 2. Give symptoms and treatment of chronic arsenical poisoning. 3. What is trichiniasis? How produced, and how may it be recognized ? 699 MEDICAL RECORD. MEDICAL JURISPRUDENCE. 1. Give medicolegal definition of wound. 2. Describe following kinds of wounds: Incised, punc- tured, lacerated, contused. What is coma? Mention three causes of coma. THERAPEUTICS. 1. What are the therapeutic uses of the silver prepara- tions ? 2. What are the indications for the use of strophanthus, of sparteine sulphate? 3. Give the methods of administering turpentine, the in- dications for its use, and the caution to be observed in its application. 4. Give therapeutic uses of salicylic acid. 5. Give the drugs applicable in the treatment of influenza and state how they should be used. 6. Give the general therapy of the preparations of am- monia. PRACTICE, ETIOLOGY, AND DIAGNOSIS. 1. What is parotis? Give symptoms. State most usual complications and how managed. 2. Give cause and treatment of myxedema. 3. Give symptoms, appearance, and treatment of herpes zoster. 4. Give physical and clinical symptoms of chronic cardiac dilatation. 5. What inferences should be drawn from persistent scanty urination? 6. What are the two varieties of jaundice, and to what is each due? 7. How would you distinguish between ascites and other abdominal enlargements ? 8. Give symptoms, dangers, and management of arterio- sclerosis. 9. What are the earliest noticeable indications of tuber- culous invasion? 10. In what condition is gastric lavage indicated, and when is it contraindicated ? 11. Differentiate between tetanus and tetany. 12. In what condition do we find: (a) temporary, and (b) persistent, enlargement of the lymphatic glands. OBSTETRICS, GYNECOLOGY, AND PEDIATRICS. i. (a) How many cases of labor have you delivered? (b) How many have you seen delivered? (c) Describe the delivery of the most difficult case you have seen. 2. Inevitable abortion at the fourth month of pregnancy : (a) Diagnosis, (b) Management in detail. 3. Define the following: (a) hydatidiform mole; (b) 700 MEDICAL RECORD Placenta succenturiata ; (c) Caput succedaneum ; (d) Vernix caseosa; (e) Melena. 4. Management of the third stage of labor. 5. Active treatment of (a) Sapremia; (b) Septic endo- metritis. 6. Necessity for and the technique of repairing second degree lacerations of the perineum following labor. 7. Cancer of breast: (a) Early diagnosis; (b) Indica- tions for operation. 8. Radical operation for the cure of cancer of breast: (a) Technique; (b) What constitutes a permanent cure? 9. Pertussis: (a) diagnosis; (b) complications; (c) prognosis; (d) prophylaxis. 10. Acute rheumatic infection in children; (a) manifesta- tions; (b) treatment. SURGERY. 1. What is meant by physiological and pathological hy- pertrophy, physiological and pathological atrophy? 2. What is meant by infection, and mention chief sources of infection? 3. Mention the chief complications of gonorrhea. 4. Define asepsis, antisepsis, disinfectant, sterile deo dorant. 5. Differentiate fracture near a joint from a dislocation. 6. What is Pott's fracture, and how should it be dressed? 7. After a clean abdominal section, what would lead you to suspect infection? 8. Give diagnosis of empyema and treatment for same. PATHOLOGY. 1. Name the varieties of degeneration. Name the form of degeneration that tubercle undergoes in chronic cases of tuberculosis. 2. What is infection? How do bacteria gain entrance into the body? What is suppuration? 3. Give the etiology and pathology of acute endocarditis. What are its results if patient survives the acute attack? 4. What is endarteritis (endoarteritis) ? What is en- darteritis obliterans, and what are its ultimate results to the tissues supplied? 5. What is granulation tissue, and under what conditions is it formed? 6. Name the blood changes in leukemia. What is the condition of the spleen and lymphatic glands in this dis- ease? BACTERIOLOGY. 1. Explain the terms obligate aerobe and facultative anaerobe. Define the terms germicide, disinfectant, anti- septic, and aseptic. 701 MEDICAL RECORD. 2. Describe (tell all you know about) the tubercle ba- cillus. 3. Name a motile, pathogenic microorganism. To what is the power of motion in certain bacteria due? Classify the most common pyogenic microorganisms. Name a pathogenic diplococcus. NEUROLOGY. i. Define the terms neurasthenia, psychasthenia, tic, and tonic and clonic as applied to the character of spasms. 2. Give the symptomatology of acute anterior poliomye- litis (infantile paralysis). 3. Give the diagnosis and treatment of locomotor ataxia (tabes dorsalis). HYGIENE. 1. Name the dangers attendant upon the use of spring and well water for drinking purposes. What precautions should be taken to protect the water from these sources? 2. Describe the hygienic treatment of pulmonary tuber- culosis. 3. Name the diseases of animals that are communicable to man. Name the chief impurities of the air in large cities. HISTOLOGY. 1. Give the histological structure of a nerve. 2. Give the histological structure of Peyer's patches and that of an artery. LARYNGOLOGY. i. What symptoms would cause you to suspect adenoids in children? 2. Define aphonia, and give its common causes. 3. What is the essential cause of diphtheria? What of pseudomembranous or true croup? Give the most impor- tant points in differential diagnosis between follicular ton- silitis and diphtheria. RHINOLOGY. 1. State four local and four general causes of epistaxis. 2. What structures are involved in hypertrophic catarrh? Give symptoms and treatment. Give symptoms and treat- ment of chronic atrophic catarrh. What is it usually called, and why so called? OPHTHALMOLOGY. 1. Define ptosis; strabismus; diplopia; myopia; hyper- metropia; presbyopia; chalazion. 2. State etiology, symptoms, and treatment of acute con- junctivitis ; also its common name when it becomes conta- gious. 3. Give etiology, symptoms, and treatment, both preven- tive and remedial, of ophthalmia neonatorum. 702 MEDICAL RECORD OTOLOGY. i. Give three methods of removing foreign bodies or impacted wax from the ear. 2. Give etiology, symptoms, and treatment of acute mas- toiditis; name three of its most common and serious results. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Medical Examining Board of Virginia, anatomy and embryology. 1. The nasal cavities are two large, irregular shaped cav- ities, situated one on each side of the middle line of the face, extending from the base of the skull to the roof of the mouth, and separated from each other by a median septum. They open in front by the anterior nares, with the face; and behind, by the posterior nares, with the naso- pharynx. They are wider below than above. Bones enter- ing into their formation are: Frontal, sphenoid, ethmoid, iacrymal, nasal, palate, superior maxillary, vomer, and inferior turbinated. 2. For description of sacrum, see any text-book on anatomy. The sacral nerves pass through the foramina in the sacrum. 3. (a) Membranes which envelop the brain: Dura, arachnoid, and pia. (b) The processes of the dura: Falx cerebri, falx cerebelli, tentorium cerebelli, and diaphragma sellse. 4. The os calcis articulates with the astragalus and cu- boid ; the astragalus with the tibia, fibula, os calcis, and navicular; cuboid with the os calcis, external cuneiform, fourth and fifth metatarsals ; navicular with the astragalus and third cuneiform; internal cuneiform with the navicu- lar, middle cuneiform, first and second metatarsals ; middle cuneiform with the navicular, internal and external cunei- form, and second metatarsal ; external cuneiform with the navicular, middle cuneiform, cuboid, and second, third, and fourth metatarsal ; the metatarsals articulate with the tarsal bones by one extremity and by the other with the first row of phalanges ; the number of tarsal bones with which each metatarsal articulates is one for the first, three for the second, one for the third, two for the fourth, and one for the fifth ; the phalanges of the first row, with the meta- tarsal bones behind and second phalanges in front ; the second row of the four outer toes, with the first and third phalanges; of the great toe, with the first phalanx; the third row of the four outer toes, with the second phalanges. 703 MEDICAL RECORD. 5. The ureter, in the female pelvis, runs downward in front of the sacroiliac synchondrosis, then upon the Obtu- rator internus and its fascia, lying behind and below the Psoas; it then enters the uterovesical fold below the oblit- erated hypogastric artery. It passes down parallel with the cervix uteri and the upper part of the vagina, behind the uterine artery, through the uterine plexus of veins, and below the broad ligament; it crosses the upper third of the vagina to reach the vesicovaginal interspace, and enters the bladder opposite the center of the vagina. 6. The nerves which supply the tongue are: (1) The lingual branch of the inferior maxillary division of the trigeminus (sensation) ; (2) chorda tympani (taste) ; (3) lingual branch of the glossopharyngeal (taste and sensa- tion) ; (4) hypoglossal (motor). 7. The muscles attached to the scapula are : Subscapu- laris, Supraspinatus, Infraspinatus, Trapezius, Deltoid, Omohyoid, Serratus magnus, Levator anguli scapulae, Rhomboideus major and minor, Triceps, Teres major and minor, Biceps, Coracobrachialis, and Pectoralis minor. 8. The abdominal aorta begins at the aortic opening in the diaphragm and extends to left side of the fourth lum- bar vertebra, where it divides into the two common iliacs. It lies to the left side of the inferior vena cava. Its branches art: (1) Phrenic, to diaphragm. (2) Celiac axis, to stomach, liver, and spleen (also to esophagus, pan- creas, and omentum). (3) Superior mesenteric, to small intestine, ascending and transverse colon. (4) Inferior mesenteric, to descending colon, sigmoid flexure, and rec- tum. (5) Suprarenal, to suprarenal body. (6) Renal, to kidney and ureter. (7) Spermatic or ovarian, to testes or ovaries, and round ligament. _ (8) Lumbar, to muscular wall and skin of abdominal cavity. (9) Middle sacral. 9. Scarpa's triangle is bounded above by Poupart's liga- ment, externally by the sartorius, and internally by the inner margin of the adductor longus; its apex is formed by the junction of the adductor longus and sartorius. The floor is formed, from without inward, by the iliacus, psoas, pectineus, adductor brevis, and adductor longus. Contents: The femoral vessels pass from about the center of the base to the apex, the artery being on the outer side of the vein ; the artery gives off the superficial and profunda branches, and the vein receives the deep femoral and in- ternal saphenous; the anterior crural nerve lies to the outer side of the femoral artery; the external cutaneous nerve is still further external, lying in the outer corner of the space; just to the outer side of the femoral artery, and in the sheath with it, is the crural branch of the genito- crural nerve. At the apex the vein (which at the base 704 MEDICAL RECORD was internal to the artery) lies behind the artery. The triangle also contains fat and lymphatics. 10. The colon is divided into ascending, transverse de- scending, iliac, and pelvic. The ascending colon extends from the cecum to the under surface of the liver to the right of the gall-bladder, where it turns to the left, forming the hepatic flexure. It lies in the right iliac and right hypochondriac regions. The peritoneum covers the anterior and lateral surfaces. Length, 8 inches. Relations. — In front: The convolutions of the ileum; behind: Iliacus, quadratus lumborum, outer side of right kidney. The transverse colon passes from right to left, from the gall-bladder to the spleen. It forms an arch, convex ante- riorly and below ; the transverse arch of the colon. It is entirely surrounded by peritoneum, which is attached poste- riorly to the spine, forming the mesocolon. Length, 20 inches. Relations. — Above: Liver, gall-bladder, large cur- vature of stomach, lower end of spleen; below: small intestines; anteriorly: anterior layers of great omentum, anterior abdominal wall; posteriorly: right kidney, second part of duodenum, transverse mesocolon, pancreas, and small intestines. The descending colon passes from the end of the trans- verse colon by a bend, the splenic flexure. Between the splenic flexure and the diaphragm, opposite the tenth left rib, is a fold of the peritoneum, the costocolic ligament, which slings up the spleen. The gut then passes down- ward to the iliac crest, ending in the iliac colon. The peri- toneum invests its anterior and lateral surfaces. Length, 4 to 6 inches. Relations.— Behind: Left crus, left kidney, quadratus lumborum, and psoas; in front: small intestines; inner side: outer border of left kidney. The iliac colon is continuous with the descending colon at the left iliac crest, and ends at the inner border of the left psoas. Peritoneum invests its anterior and lateral surfaces ; it has no mesentery. Length, 5 to 6 inches. Rela- tions.— In front: Small intestines; when distended, the an- terior abdominal wall; behind: left iliopsoas. The pelvic colon extends from the inner border of the psoas to the level of the third sacral vertebra. Length, 16 or 17 inches; very variable. It has an extensive mesen- tery. Relations.— Passing over left brim of pelvis, it crosses the left external iliac vessels and left ureter, and passes to right margin of pelvis, resting on bladder in male and uterus in female ; above lie coils of small intestine. It then turns back to midline on posterior wall of pelvis, and, forming a second bend, descends to end in the rec- tum.—- (From Aids to Anatomy.) 705 MEDICAL RECORD. PHYSIOLOGY. i. In the mouth: The food is crushed, mixed with saliva, and reduced to a pulp; it is rendered slightly alka- line, and a small amount of starch is converted into mal- tose; the proteids and fats are unaltered. In the stomach, where the contents are rendered acid, conversion of starch into sugar ceases, connective tissue of fats is dissolved and fats are set free.' Proteids are dissolved and peptones formed. The albuminous foods are dissolved for the most part, and a grumous mixture of peptones, liquid fats, and starches is formed, which is termed chyme, and is gradu- ally passed through the pylorus into the intestine. 2. In its passage through the lungs, the blood (i) be- comes cooled; (2) becomes a brighter red color; (3) gains oxygen (about 10 or 12 volumes) ; (4) loses carbon diox- ide (about 7 volumes). Tidal air is the air which is constantly passing in and out of the lungs during ordinary calm respiration. It measures about 30 cubic inches. Residual air is the air which still remains in the lungs after the deepest expira- tions. It measures about 100 cubic inches. 3. The salts and also the watery constituent of the urine are both excreted by the glomerulus of the kidney. Urine is a yellowish liquid, acid in reaction, specific gravity from about 1015 to 1025. About fifty ounces are excreted in twenty-four hours. Its normal constituents are : Water, urea, uric acid, urates, hippuric acid, kreatinin, xanthin, hypoxanthin, sulphates, chlorides, and phosphates c T sodiutn and potassium, phosphates of magnesium and nlcium, nitrogen, and carbon dioxide. 4. The solar plexus is formed by the great, small, and least splanchnic nerves of both sides, and by the right pneumogastric nerve; the two semilunar ganglia, and other ganglia, also enter into its composition. It supplies all the viscera in the abdominal cavity. 5. The seventh cranial or facial nerve has its superficial origin in the upper end of the medulla oblongata, in the groove between the olivary and restiform bodies. It passes "forward and outward to enter the internal auditory meatus; it lies upon a groove on the auditory nerve, with portio intermedia of Wrisberg between, and at the bottom of the meatus it enters the aqueductus Fallopii, along which it runs first outward between cochlea and vestibule as far as hiatus Fallopii ; then backward in internal wall of tympa- num, just above fenestra ovalis, at the turn presenting a swelling, the geniculate ganglion; and finally it passes downward to emerge from the bone at the stylomastoid foramen ; it then passes outward and forward in the paro- tid, dividing behind the ramus of the jaw into temporo- 706 MEDICAL RECORD. facial and cervicofacial branches, which further subdivide and intercommunicate, forming the pes anserinus." — {Aids to Anatomy.) Function: The facial nerve is the motor nerve of the muscles of expression, also of the platysma and the bucci- nator; it also supplies the muscles of the external ear, the stylohyoid, and the posterior belly of the digastric. Through the chorda tympani it is a nerve of taste and a vasodilator of the vessels of the submaxillary and sublingual glands. 6. The glands connected with the skin are the sweat glands and the sebaceous glands. The sweat glands secrete the sweat or perspiration, whose function is (i) excre- tion of water, carbon dioxide, and urea; (2) to cool the surface of the body; and (3) to regulate the body heat. The sebaceous glands secrete sebrum, whose function is : To lubricate the skin and keep # it flexible ; to prevent undue absorption, and to keep the skin from getting macerated. The respiratory center is in the medulla, at the apex of the calamus scriptorius. (Subsidiary centers are also found in the spinal cord.) MATERIA MEDICA. i. Preparations of manganese: (1) Precipitated man- ganese dioxide; dose, gr. iv. It has an astringent action. (2) Manganese hypophosphite ; dose, gr. iij. It has little or no physiological action. (3)^ Manganese sulphate; dose, gr. iv. Its action is first astringent, later emetic and pur- gative, (a) Potassium permanganate; dose, gr. j. It is a deodorant and disinfectant; also irritant. 2. Emetine is, in small doses, a gastric stimulant; it then acts on the vomiting center in the medulla, and is thus an indirect emetic; it produces but slight nausea and depres- sion; it stimulates the bronchi to increased secretion, mod- erately depresses the circulation, is a slight diaphoretic, and acts on the liver as a direct cholagogue. 3. "The action of hyoscyamus is almost identical with that of belladonna and stramonium. The following are the chief points of difference: (1) Hyoscyamus contains in addition hyoscine in minute quantities. This is a powerful cerebral and spinal sedative, and therefore the excitation and delirium occasioned by the atropine in belladonna are not so evident when hyoscyamus is given; indeed, that may, owing to the hyoscine in it, distinctly depress the higher functions of the brain. The heart is not quite so power- fully affected by hyoscyamus as by belladonna, for hyo- scine has a comparatively feeble cardiac influence. Still, it is, of course, affected by the hyoscyamine, which acts like atropine. (2) Hyoscyamus increases the peristaltic con- tractions of the intestines more powerfully than bella- donna, and at the same time it is more efficient in relieving 707 ^ MEDICAL RECORD. the griping of other purgatives. (3) Hyoscyamus has a more markedly sedative action on the urinary unstriped muscle than belladonna." — (White & Wilcox's Materia Me die a, etc.) 4. The toxic action of the salts of mercury is indicated by: Pain in mouth and stomach, gastroenteritis, hemate- mesis, bloody stools, scanty and albuminous urine with casts, salivation. Antidote: White of egg in moderate quantity, followed by an emetic. 5. Ergot is the sclerotium of the claviceps purpurea. It excites contractions in the parturient uterus. The dose of the fluid extract is thirty minims. 6. The principal alkaloids of opium are: Morphine, co- deine, thebaine, narcotine, narceine, papaverine. In sopo- rific effects, beginning with the most powerful, they rank: Narcotine, morphine, codeine; in tetanizing action: The- baine, papaverine, narcotine, codeine, morphine; in toxic action: Thebaine, codeine, papaverine, narceine, morphine, narcotine. Antagonists: Potassium permanganate, atropine, caf- feine, and strychnine. CHEMISTRY. 1. Iodine is a solid crystalline substance, having a blue- gray color and metallic luster ; the vapor has a violet color and a peculiar odor, and is very irriating to the eyes and nose. It stains the skin, and is poisonous. It is only slightly soluble in water. It is obtained from seaweed. Test for iodine: Add starch paste; in the presence of iodine it becomes blue. 2. The alkali metals are: Lithium, sodium, potassium, rubidium, cesium (and silver). They are all solids, uni- valent; their hydroxides are more or less alkaline and are basic; they form one chloride and one or more oxides. 3. Potassium iodide. KI. Potassium permanganate, K 2 Mn 2 0s. Potassium chlorate, KC10 3 . The first is used in the third stage of syphilis, gonorrheal rheumatism, aneurysm, pleurisy, asthma, pericarditis.^ The second ^ is used as a disinfectant, deodorant, and antiseptic. The third is used in sore throat, tonsillitis, and stomatitis. 4. Potassium permanganate is a very active oxidizing agent, and its action as a disinfectant is due to the oxida- tion of the organic matter with which it comes in contact. The splitting up of potassium permanganate and the prompt liberation of the oxygen is shown in the following equa- tion : 2K 2 Mn 2 8 + 2H 2 = 4Mn0 2 + 4KHO + 30 2 . 5. Mercuric chloride, HgCl 2 , corrosive sublimate, is heavy, white, and crystalline; it has a strong, acrid, styptic taste and is soluble in water, in alcohol, and in ether; it is 708 MEDICAL RECORD. decomposed by exposure to light. It is used as a disin- fectant, antiseptic, antiparasiticide, and as a cholagogue. Mercurous chloride, Hg 2 Cl 2 , calomel, is a heavy, white powder, amorphous, tasteless, and odorless ; it is insoluble in cold water and in alcohol, and very slightly soluble in boil- ing water; when exposed to the light it becomes discolored (first yellow, then gray) and partially decomposed; it sub- limes without fusing; it is incompatible with the mineral acids, with the alkaline chlorides, bromides, and iodides. It is used as a laxative, purgative, diuretic ; in cases of vomit- ing, liver congestion or cirrhosis, and as a dusting powder. 6. Chloral hydrate. Formula, CC1 3 CH(0H) 2 . It is pre- pared by adding a little water to chloral. It is used as a hypnotic and sedative; as a solvent for resins, starch, etc.; also in alcoholism, mania, high arterial tension, tetanus, and strychnine poisoning. TOXICOLOGY. i. The symptoms of acute arsenical poisoning: Nausea and f aintness, severe burning pain in the stomach, persistent vomiting of matters, sometimes brown or gray, or streaked with blood, or green; purging, and cramps in the legs. Treatment: Induce vomiting, by zinc sulphate; use stom- ach tube. The chemical antidote is freshly prepared ferric hydroxide. The ferric hydroxide changes the arsenic into ferrous arsenate, which is nonpoisonous. 2. Symptoms of chronic arsenical poisoning: Inflamma- tion of the conjunctivae, with intolerance of light. Irritation of the skin, accompanied by an eruption (eczema arseni- cale) ; local paralyses; great weakness and emaciation; ex- foliation of the cuticle and falling out of the hair. Treat- ment: Remove the patient from the exposure and treat the symptoms as they arise ; potassium iodide has been rec- ommended. 3. Trichuriasis is the condition resulting from eating pork containing Trichina spiralis. It is characterized by gastrointestinal irritation, diarrhea, colicky pains, vomit- ing, fever, sweating, edema of the face and eyelids, great prostration, muscular soreness, emaciation, pronounced leucocytosis, especially increase of the eosinophiles. The trichina may be found in pieces of muscle excised for pur- poses of examination, or in the stools. MEDICAL JURISPRUDENCE. i. A wound (medicolegal) is any injury or lesion caused by mechanical or chemical means. 2. Incised wounds are made by sharp-cutting instru- ments ; the hemorrhage is free, the wound gapes, there is no bruising of the margins. Punctured wounds are deep wounds with a small orifice ; they are made by narrow in- 709 MEDICAL RECORD. struments. Lacerated and contused wounds are made by blunt instruments and by crushing; the soft parts are torn, the edges are bruised and ragged, the deep parts are infil- trated with blood ; there is little free bleeding. Coma is a condition of profound insensibility, chiefly due to a changed condition of the brain. Three causes of coma: Apoplexy, opium, alcohol. THERAPEUTICS. 1. Therapeutic uses of silver preparations: As a caustic ; for septic processes, boils, and phlebitis; for gonorrhea; for bedsores ; in gonorrheal ophthalmia ; also as a prophy- lactic; in dysentery or diarrhea; for ulcers of mouth, stomach, or intestines. 2. Indications for strophanthus: As a cardiac stimulant ; in mitral or aortic obstruction; in cardiac dilatation; pal- pitation; alcoholism; exophthalmic goiter; nephritis; when heart action is feeble but rapid, and accompanied by low arterial tension ; in general, same as digitalis. Indications for sparteine sulphate: As a diuretic, in cardiac or renal dropsy; also in uncompensated mitral or other cardiac lesions. 3. Turpentine can be administered: Locally, as a lini- ment, as a stupe, by enema, in emulsion, in capsules, on cut sugar, by inhalation, as a spray. Indications: As^ a rubefacient or counterirritant ; sciatica, lumbago, neuralgia, chronic rheumatism, sprains, dysentery, hemorrhage of intestines; as a vermifuge against tapeworm; chronic bronchial affections and chronic affections of the genito- urinary tract. Caution: Too large doses may produce gastroenteritis, diarrhea, vomiting, suppression of urine, hematuria, strangury; it acts, in toxic doses, as a narcotic poison. 4. Therapeutic uses of salicylic acid: "Externally as antiseptic and stimulating applications and for the check- ing of abnormal perspiration; also in parasitic and other skin diseases. Internally, rheumatic fever (in which it seems to act as a specific) ; gout; migraine; sciatica; dia- betes; cholelithiasis." — (Wilcox, Materia Medica.) 5. For influenza: The following (among many) have been recommended: Ammonium chloride, alkaline drinks, antipyrin, antiseptics, aperients, arsenic, bismuth, cam- phor, chloroform, Dover's powder, heroin, hydrocyanic acid, morphine, phenacetin, quinine, salicin, strychnine, aconite, sweet spirit of niter, alcohol, belladonna, bromides, cannalis indica, chloral or sulphonal, ergot. 6. Ammonium preparations. — Externally : Rubefacient, vesicant, for bites of insects. Internally: As a gastric, cardiac, or general stimulant; as an expectorant; hepatic disorders; muscular rheumatism; diaphoretic and diuretic. 710 MEDICAL RECORD. PRACTICE, ETIOLOGY, AND DIAGNOSIS. i. Symptoms of parotitis: Chilliness, malaise, moderate fever, pain and swelling of parotid gland, which becomes tender and elastic, but shows no fluctuation; deglutition and mastication are painful; both sides may be affected. Complications: Unilateral orchitis, which may be fol- lowed by atrophy of testicle; in the female, mastitis or edema of vulva or ovaritis. Management: Keep patient in bed : isolate him ; salines, hot fomentations, and antiseptic mouth wash. The orchitis will need rest, suspension, and an application of guaiacol ointment or lead and laudanum; afterward mercury and belladonna ointment. 2. Myxedema. — Cause: Loss of function of thyroid gland; heredity is supposed to have some influence; it is most common in women. Treatment : Keep patient warm, give nourishing food, and administration of sheep's thy- roid. 3. Herpes zoster. — Symptoms and appearance: Malaise, slight fever; vesicles, in cluster, and on inflammatory base, usually along the course of intercostal nerves, but may be in other locations; it occupies areas which repre- sent the distribution of nerve fibers that enter a single posterior root ganglion; as a rule it is unilateral and accompanied with sharp neuralgic pain. Treatment: Zinc phosphide, morphine, and phenacetin have been given; locally, menthol or collodion may be applied. 4. In cardiac dilatation: "The symptoms are those of failing circulation: precordial anxiety, palpitation, head- ache, vertigo, syncope, pallor, cough, dyspnea, venous con- gestion, and dropsy. The cardiac impulse is feeble and dif- fused, and usually displaced to the left. The area of cardiac percussion-dullness is increased. The first sound is weak- ened in correspondence with the disproportion between the enlargement of the cardiac chambers and the thickness of their walls; the second is little changed. If the dilatation has been great enough to so enlarge the orifices or weaken the muscles that the valves are no longer competent to effect complete closure, regurgitant murmurs may be de- veloped, even in the absence of structural alterations in the valves. Such murmurs are usually rather soft and may be inconstant. The action of the heart may be rapid and irreg- ular. The pulse is small and soft." 5. Persistent, scanty urination may denote : Heart dis- ease, with broken compensation; degeneration of cardiac muscle ; parenchymatous nephritis ; chronic diseases of the respiratory apparatus; chronic uterine or liver disease; mechanical obstructions, such as compression of the ure- ters by tumors, or an enlarged prostate gland. 6. The two varieties of jaundice are (1) obstructive and (2) nonobstructive, or toxemic. 711 MEDICAL RECORD. Obstructive jaundice may be due to: Gastroduodenal catarrh; catarrh of the bile ducts; lodgment of gallstones or round worms in the common duct; pressure on or clo- sure of the duct by tumor of the liver, stomach, kidney, omentum, and especially of the pancreas ; and new growths or cicatricial tissue producing stricture or obliteration of the lumen of the duct. Nonobstructive or toxemic jaun- dice may be due to : "Influenza, malaria, pneumonia, typhoid, typhus, scarlet fever, yellow fever, pyemia, ulcerative en- docarditis, acute yellow atrophy of the liver, WeiFs dis- ease, snake venom, antimony, arsenic, chloral hydrate, chloroform, ether, copper, mercury, phosphorus, and potas- sium chlorate/' — (From Butler's Diagnostics of Internal Medicine.) 7. Ascites is characterized by: Enlargement of the abdo- men, most marked in the flanks when the patient is lying on his back, and in the hypogastrium, when he is standing up ; there are dilated superficial veins on the abdomen, and the skin is tense ; the umbilicus is prominent ; there are fluctuation and vibration on palpation ; dullness is found on percussion over the fluid, while the center of the abdo- men is resonant. 8. Arteriosclerosis. Symptoms: "Increased tension in the pulse, causing a hardness, often feeling like 'pipe- stems/ Great hypertrophy of the cardiac muscle ensues. The coronary arteries may be involved, leading to fibroid degeneration, fatty degeneration, and the symptoms of angina pectoris, absence of compensation, dyspnea, scanty urine, and other symptoms. The cerebral arteries may be involved, and hence apoplexy is common. The kidneys may next suffer, giving rise to interstitial nephritis or con- tracted kidney." Dangers: Cardiac, renal or cerebral troubles. Management: "Seek diligently for any predis- posing cause. Alcohol in any form should be absolutely interdicted. Attacks of gout and rheumatism should be prevented as far as possible by the restriction of animal foods, tea, and coffee. In these cases a vegetable diet is best. If due to heart disease, kidney disease, or syphilis, each will require its special line of treatment. The kidneys may be kept active by diuretics. At the same time the skin should be kept active by proper amount of exercise, hot baths, and thorough massage." — (Gould & Pyle's Pocket Cyclopedia.) 9. The early manifestations of pulmonary tuberculosis are: (1) Physical signs: Deficient chest expansion, the phthisical chest, slight dullness or impaired resonance over one apex, fine moist rales at end of inspiration, expiration prolonged or high pitched, breathing interrupted. (2) Symptoms: General weakness, lassitude, dyspnea on exer- 712 MEDICAL RECORD. tion, pallor, anorexia, loss of weight, slight fever, and night sweats, hemoptysis. 10. Lavage is said to be indicated in : Gastric dilatation and chronic gastritis. It is contraindicated in : "Marked prostration, continued fevers, or cachectic states ; broken compensation of heart lesions; advanced fibrous or fatty degenerations of the heart, and angina pectoris; thoracic aneurysm and advanced general arteriosclerosis ; last stages of pulmonary tuberculosis, emphysema, bronchitis, and recent hemoptysis; gastric ulcer with recent hematemesis or tarry stools; recent intracranial, renal, vesical, or rectal hemorrhages; and pregnancy and old age." — (Butler's Diagnostics of Internal Medicine.) ii. Tetanus is a condition of persistent tonic spasm of voluntary muscles; also a disease due to a specific bacillus. Tetany is a bilateral, tonic spasm of the extremities. 12. Enlarged lymphatic glands, (a) Temporary, in: Diphtheria, tonsillitis, scarlet fever, measles, erysipelas, variola, suppurative ear disease, gonorrhea, chancroid, (b) Persistent, in : Leukemia, Hodgkin's disease, tuberculosis, syphilis, filaria, malignant disease. OBSTETRICS, GYNECOLOGY, AND PEDIATRICS. 2. Inevitable abortion, (a) Diagnosis: Hemorrhage profuse and continuous, clotted and dark colored ; pain cramp-like and severe ; cervical canal dilated ; uterus soft and enlarged, and the angle between the upper and lower uterine segments is effaced ; the discharge consists of dark blood, clots, and portions of ovum; signs of pregnancy present, except amenorrhea. (b) Management: "Two methods of treatment have been advised for these cases. The first is the expectant plan: Place the patient in bed, and if the bleeding is pro- fuse, insert a tampon of iodoform gauze (one yard) well up against the cervix. If this fails to control the hemor- rhage, reinforce it by another yard or two of gauze and a perineal pad and binder. Small doses (3^) of the fluid extract of ergot should now be given every two or three hours. At the end of from eight to twelve hours remove the tampon, when the ovum may be found extruded from the cervix; if not, a vaginal douche of mercuric chloride (i 14000) must be given, and another tampon introduced. If, upon the removal of this second tampon at the end of ten or twelve hours, the ovum is not discharged, then more vigorous methods to secure its expulsion must be adopted. Active plan: The physician's hands and instruments are sterilized ; the patient is etherized and placed on an appro- priate table ; the genitalia are thoroughly cleansed and a vaginal douche of mercuric chloride (i 14000) is given; the anterior lip of the cervix is brought down to the vulvar 713 MEDICAL RECORD. orifice; the cervix is dilated if necessary; the placental for- ceps is introduced into the uterus, and as much as possible of the ovum is removed; the uterus is thoroughly curetted, and an intrauterine douche of sterile water is given. A light tampon of iodoform gauze is placed in the vagina; the patient is then returned to bed. A strip of gauze may be placed in the uterus in cases of sharp retroflexion, to secure free drainage, and occasionally an intrauterine tam- pon will be necessary when the uterus refuses to contract and hemorrhage persists after the use of the curette." — (Gould & Pyle's Pocket Cyclopedia.) 3. (a) Hydatidiform mole is a product of conception which has undergone degeneration, and in which the chor- ionic villi have proliferated so as to produce a mass of cysts somewhat resembling a duster of grapes. (&) Pla- centa succenturiata is a subsidiary placenta, occasionally found, in addition to the ordinary placenta, (c) Caput suc- cedaneum is a tumor formed during labor upon the pre- senting part of the fetus; it is due to the absence of pressure at that part, (d) Vernix caseosa is a greasy sub- stance made up of sebum and desquamated epithelium; it is found on the skin of the fetus at birth, (e) Melena is the discharge of feces colored black by blood which has undergone changes in the stomach or intestines. 4. For the management of the third stage of labor, see any text-book on obstetrics. 5. (a) Sapremia is treated: Removal of the decompos- ing matter by finger, curette, or douche; drainage and asepticizing the affected area; purgatives and diuretics are given; also diaphoretics and stimulants; saline by hypo- dermoclysis or # infusion ; ^ food must be fluid concen- trated, and nourishing; tonics are indicated; symptoms are treated as they arise, (b) Septic endometritis is treated: Disinfection of the genital canal, as far as possible; sterile water, saline solution, antiseptic fluids, and curette are all useful; tamponade may be advisable; general treatment as in sapremia. 6. All tears should be repaired as soon as possible (un- less there are contraindications). A primary operation is best, because the edges are fresh and can be approximated ; little (if any more) anesthetic is wanted; the woman has to lie in bed, and therefore only one absence from house- hold work is requisite ; infection is less likely. In any case, operation may prevent rectocele, cystocele, prolapse of uterus, and general weakness, malaise, and disability. For technique, see any text-book on obstetrics or gynecology. 7. Cancer of breast. Early diagnosis: Is only conjec- tural without microscopical examination of a piece of the growth ; but a hard nodule, generally painless, steadily in- 714 MEDICAL RECORD. creasing in size and incorporated with the gland tissue, should lead one to suspect cancer. Later on the skin is dimpled and may ulcerate, the nipple may be retracted, pain is present, and the breast cannot be freely moved. Indications for operation: As soon as diagnosed, and the earlier and more thorough the better. 8. (a) For technique of radical operation, see any text- book on surgery, (b) The case is considered "cured" if there is no return within three years of the opera- tion. 9. Pertussis, (a) Diagnosis: Paroxysms of short, spas- modic coughs followed by a long-drawn inspiration and a "whoop"; the paroxysm may cause puffiness of the face and end in vomiting; the eyes are suffused, (b) Compli- cations: Convulsions, vomiting, bronchopneumonia, col- lapse of lung, emphysema, nasal or conjunctival hemor- rhage, cancrum oris, paralysis of various kinds, (c) Prog- nosis: Guardedly favorable; when complications are pres- ent the prognosis is more grave; the character of the epi- demic, the age of the child, the care it receives, the number and severity of the paroxysms are all factors to be noticed. (d) Prophylaxis: Isolation of patient, disinfection of all articles used by him, quarantine while the cough lasts. 10. _ Rheumatic manifestations in children : Fever, sour perspiration, scanty, high-colored urine, arthritis, cardiac lesions with murmur (soft, systolic), accentuation of sec- ond heart sound, anemia, night terrors, chorea, quickened pulse, tonsillitis, pericarditis, pleurisy, pneumonia, (b) Treatment: Rest in bed between flannels and blankets, milk diet; swollen joints should be wrapped in wool; calomel, sodium salicylate, "alkaline treatment" are the main indications. SURGERY. 1. Hypertrophy is said to be physiological when it occurs as a phase of the normal life history of the body (such as enlargement of uterus during pregnancy, enlargement of female breast at puberty, and in connection with pregnancy and lactation). All other hypertrophies are pathological. Atrophy is said to be physiological when it occurs as a phase of the normal life history of the body (such as involution of the uterus after parturition; atrophy of the thymus in childhood). All other atrophies are pathological. 2. By infection is meant the invasion of the living tissues by bacteria, in such a manner as to produce local or gen- eral disease. Chief sources of infection: Dust, polluted food or water; wounds of all sorts; unclean implements, sueh as knives, spoons, cups, dental or surgical instru- 715 MEDICAL RECORD. ments; fomites; urine, feces, sputum; clothes, dressings; discharges. 3. The chief complications of gonorrhea may be : Cysti- tis, epididymitis, prostatis, vesiculitis, periurethritis, bubo, retention of urine, stricture, gonorrheal rheumatism, and arthritis. In the female: Cystitis, labial abscess, vaginitis, endo- metritis, salpingitis, ovaritis, peritonitis, and sterility. 4. Asepsis is/ the absence of infection. Antisepsis is de- struction or arrest of growth of infective germs. Disin- fectant is an agent which restrains infectious diseases by destroying or removing their specific poisons. Sterile means having no living microorganisms. Deodorants are substances which destroy the odorous products of putre- faction. FRACTURE. 1. Crepitus may be present. 2. Preternatural mobility. 3. Easily reduced — but 4. Deformity more liable to recur after reduction. 5. The head of the bone is in its proper place. 6. The socket containing the head of the bone is not empty. 7. When rotated the bone does not move as one piece. DISLOCATION. 7- Crepitus never present. Rigidity rather than mo- bility. Difficult to reduce — but Deformity less liable to recur after reduction. The head of the bone is not in its proper place. The socket which should contain the head of the bone is empty. When rotated the bone moves as one piece. 6. Pott's fracture is a fracture of the lower end of the fibula, with outward displacement of the ankle. Dressing: After reducing the displacement by extension and manipu- lation, the limb should be placed in a fracture-box pro- vided with a soft pillow, the foot should be secured to the footboard, and a pad of oakum or cotton should be placed under the tendo Achillis; before bringing up the sides of the box and securing them, two firm compresses of lint or oakum should be placed in contact with the leg and foot, one just above the inner malleolus, the other just below the outer malleolus. The sides of the box are next brought up and secured, and by the pressure of these compresses the foot is brought into an inverted position and the deformity is corrected. The after-dressing of this fracture consists in letting down the sides of the box, and in inspecting the parts to see that the foot is kept in the proper position, and care should be taken that undue 716 MEDICAL RECORD pressure is not made upon the skin by the compresses, which might result in ulceration ; this may be avoided by sponging the skin with alcohol and changing the positions of the compresses slightly at each dressing. At the ex- piration of ten days the fracture-box and compresses may be removed and the limb put up in a plaster-of-Paris dress- ing, including the foot and leg, up to the knee. The pa- tient may then be allowed to go about on crutches, and at the end of five weeks all dressings may be dispensed with." — (Wharton's Minor Surgery.) 7. After clean abdominal section, infection may be sus- pected : If the body temperature is high, if there are chills, exhaustion, marked leucocytosis, night sweats, emaciation. 8. Empyema. Symptoms: Fever, sweats, chill, dimin- ished breath sounds and vocal fremitus, impaired mobility of chest, dullness on affected side, heart displaced to oppo- site side, leucocytosis. Diagnosis is made by respiration, showing the fluid to be pus. Treatment: Aspiration, drain- age, irrigation, resection of ribs (Estlander's operation), or resection of chest wall (Schede's operation). PATHOLOGY. i. The varieties of degeneration are : Fatty, amyloid, mucoid, hyaline, cheesy or caseous, colloid, hydropic, and cloudy swelling. Tubercle, in chronic cases of tuberculo- sis, undergoes cheesy or caseous degeneration. 2. See above, Surgery, number 2. Suppuration is necro- sis and liquefaction of living tissues; it is bacterial in origin, and usually begins as inflammation. 3. Acute endocarditis. Etiology: Microorganisms (chiefly Staphylococcus pyogenes aureus, Streptococcus pyogenes, Diplococcus pneumoniae, gonococcus, and others) ; acute articular rheumatism, pneumonia, scarlet fever, puer- peral sepsis, nephritis, etc., are said to be etiological factors. Pathology: The valves (mitral, aortic, and pulmonary), and endocardium of ventricles and left auricle are chiefly involved. The valves are affected on a line very near to the free edge ; the chordae tendinece also suffer, and the endocardium of the left ventricle, near the septum. Opac- ity, roughness, nodular elevations, fibrous deposit, ulcera- tion have all been observed. Results: Calcification, de- struction of chordae tendinece or valve, myocarditis, peri- carditis, embolism, infarcts or metastatic abscesses in spleen, brain, or kidneys. 4. Endarteritis is inflammation of the inner coat of an artery. Endarteritis obliterans is endarteritis in which the lumen of the affected vessel is almost obliterated. . Ulti- mate results to tissues: The blood supply is cut off; in the brain, cerebral softening and paralysis result; neuralgia may occur ; hemorrhage is prevented. 717 MEDICAL RECORD. 5. Granulation tissue is embryonic tissue consisting of loops of new formed capillaries covered by round cells, and sometimes also by giant cells. It is formed as a result of inflammation during the repair of wounds when apposition is not perfect. 6. In leukemia, the blood is light in color, specific gravity is lowered, coagulation is slow, the white corpuscles are much increased in number (there may be from 150,000 to 500,000 per c. mm., or even more) ; myelocytes are present in large numbers in the splenomedullary type; red cells may be moderately diminished, and some may be nucleated. The spleen and lymphatic glands are enlarged. BACTERIOLOGY. 1. Obligate aerobe is a term applied to such bacteria as cannot exist without oxygen. Facultative anaerobe is a term applied to such bacteria as thrive better without oxygen, but still can manage to exist in oxygen. Germi- cides are agents which destroy bacteria and their germs. Disinfectants are agents which restrain infectious diseases by destroying or removing their specific poisons. Anti- septics are agents which destroy infection. Aseptic means absence of infection, or freedom from germs. 2. The tubercle bacillus is rod shaped, is from 1^2 to S T A mikrons in length, and about one-third to one half a mikron in breadth, is a strict parasite, is not motile, and has no flagella. It is slightly curved, does not form spores, is not liquefying, and nonchromogenic, is aerobic; it re- sists acids: it grows well on blood serum; stains well by Ehrlich's, Ziehl-Nielsen's, or Gabbett's method; it is Gram- positive. 3. A motile pathogenic microorganism: Bacillus typho- sus. The power of motion is due to flagella. The most common pyogenic microorganisms: Staphylococcus pyo- genes aureus, Staphylococcus pyogenes albus, Staphylococ- cus pyogenes citreus, and Streptococcus pyogenes. A path- ogenic diplococcus : The gonococcus. NEUROLOGY. 1. Neurasthenia is a condition in which nervous energy is diminished, and sensitiveness to external impressions is increased. Psychasthenia is mental fatigue. A tic is a spasmodic and involuntary contraction of the (facial) muscles ; also a neurosis.^ In tonic spasms, the contractions are continuous. In clonic spasms, the contractions are in- termittent. 2. Symptoms of acute anterior poliomyelitis: Some fevef, chills, and convulsions may precede the paralysis, or the onset may be sudden; certain groups of muscles (generally in the extremities) are paralyzed; hemiplegia is 7i8 MEDICAL RECORD. rare; the reflexes are generally lost; the paralysis is ir- regular in its distribution, and tends to ameliorate, but the recovery is only partial; the affected muscles waste, and the limb is cold and livid. 3. Locomotor Ataxia. Symptoms: Loss of coordina- tion; characteristic and unsteady gait; tendency to stagger when standing up with feet together and eyes closed; sharp and paroxysmal pain, called crises; girdle sensa- tion; loss of knee-jerk and other reflexes; Argyll-Robert- son pupil. The diagnostic features are : A slow onset ; the loss of the patellar reflexes; Argyll-Robertson pupil; light- ning pains; incoordination. Treatment: Rest, tonics (strychnine, arsenic, iron, and phosphorus) ; easily digest- ible food; hydrotherapy; massage; electricity; reeducation of muscles; avoidance of all excesses, cautery; anodynes. HYGIENE. 1. Dangers incident to drinking spring and well water: Surface water, filth, sewage, and, indeed, anything may be conducted into these waters. Hence, the possibility of disease being caused by drinking this water. The wells and springs should be at a distance from dwelling houses, especially from outhouses, privies, etc.; they should be well protected and covered, so that no extraneous matter can enter them. All shallow wells should be protected with good coping stones and good masonry for several feet below the surface. 2. Hygienic precautions to be taken in treating a case of tuberculosis: "The patient's quarters should be free from dust, and admit of spending many hours daily in the open air in all weathers, properly sheltered, and, if very ill, lying wrapped in a hammock or reclining chair. His bed- room should be well aired at night, draughts being avoided. The room should be uncarpeted and free from hangings. It should be often cleaned and periodically disinfected. All sputum should be collected in paper spit-cups, which should be burned daily. Smoking should be forbidden. Harm is done by any exercise which results in fatigue, and while fever exists it should not be attempted at all. Patients should be taught the necessity of practising lung gymnas- tics and breathing only through the nose, which should be kept clear and free from occlusion by secretions, or an hypertrophied catarrhal mucosa. . . . The clothing should be woolen, but not too heavy, or sweating is in- creased ; and a flannel nightgown and loosely knit leggings should be worn at night in cool weather. The skin should be cleansed by daily sponge-baths of lukewarm alcohol and water/' — (Thompson's Practical Medicine.) 3. Diseases of animals communicable to man: Glanders, anthrax, tuberculosis, rabies, aphtha, tapeworm and^ other intestinal parasites, ringworm, echinococcus, diphtheria. 719 MEDICAL RECORD. J Chief impurities of air in large cities: Mineral matters, as silica, calcium, iron; coal dust; spores of moulds and bacteria; organic matter; ammonia; fibers of cotton, wool, or silk; dust and fibers from industrial processes; gases, products of combustion. HISTOLOGY. 1. A nerve consists of a bundle of fibers bound together by a sheath called the epineurium; it contains blood-vessels, lymphatics, connective tissue cells; each nerve bundle is surrounded also by a sheath called the perineurium. Med- ullated fibers consist of a neurilemma, medullary sheath, and axis cylinder. Nonmedullated fibers have an axis cyl- inder, but no sheath. Nerve cells have cell-body, nucleus, and one or more processes (axis cylinders and dendrites). 2. Peyer's patches are clumps of solitary glands covered with mucous membrane and surrounded by crypts of Lie- berkiihn. Each of these solitary glands is a lymph nodule consisting of retiform tissue, lymph corpuscles, and capil- laries. They are situated in the mucous and submucous tissue of the small intestine, chiefly the ileum. Arteries consist of three coats: (i) Tunica intima, con- sisting of fenestrated membrane of Henle, and a fine line of white fibrous tissue; (2) Tunica media, consisting of elastic fibers and involuntary muscles; (3) Tunica ad- ventitia, consisting of white fibrous tissue and a few elastic fibers. The middle coat is the thickest. LARYNGOLOGY. i. The symptoms of adenoids in children are : Mouth- breathing ; snoring ; open-mouth ; a vacant, dull expression of the face; modification of the voice. Effects: Otitis, coryza, mental deficiency, stunted growth, and various neuroses. 2. Aphonia is loss of voice, caused by: Laryngitis, edema or tumor of larynx, improper use of the voice, retro- pharyngeal abscess, paralysis, fixation of the vocal cords, by cicatricial contractions, ulceration of the vocal cords, foreign bodies in the larynx, and hysteria. 3. The essential cause of diphtheria is the Klebs-Loefiler bacillus. The essential cause of true croup is either the Klebs-Loeffier bacillus, or the Streptococcus pyogenes. ' In diphtheria the onset is more gradual ; the temperature rises to about 101 to 103 F. ; the tonsils are not much enlarged; there is an exudate of a thick grayish membrane which is very adherent, is removed only with difficulty, and leaves a bleeding surface; this membrane soon re-forms, and may be found on the fauces and pharynx as well as on the tonsil; in the exudate the Klebs-Loeffier bacilli may be found. In follicular tonsillitis the onset is more sudden ; 720 MEDICAL RECORD. the temperature may be a little higher than that of diphthe- ria ; there is no membrane, but the tonsils are red and swollen, and in the crypts are seen white cheesy spots or plugs, which consist of broken-down epithelium, and are easily brushed away; Klebs-Loeffler bacilli are never found. RHINOLCGY. 1. Local: Trauma, caries of nasal bones, ulceration, new growths. General: Purpura hemorrhagica, hemophilia, scurvy, pernicious anemia. 2. Mucosa of nasal cavity, especially of inferior turbi- nated bones. Symptoms: Increased secretion, obstruction, sneezing, loss of resonance of voice, impaired olfaction, bad breath. Treatment : Cleansing alkaline spray, astrin- gent spray, cauterization, incision, or turbinectomy. Chronic atrophic catarrh. Symptoms: Blocking of the nose with thick, offensive crusts ; nasal fossae dilated ; anosmia. Treatment : A warm, alkaline, cleansing douche; the crusts must be removed ; tampons with ichthyol, fol- lowed by an oil spray, have been recommended. It is usually called ozena, on account of the offensive fetid smell. , OPHTHALMOLOGY. \J / 1. Ptosis is a drooping of the upper eyelid. Strabisnius is a perceptible deviation of one of the eyes from the proper direction, diplopia is the condition in which an object appears double. ^Myopia is a condition in Avhich the parallel rays are focused in front of the retina. Hyperme- tropia is a condition in which the parallel rays are focused behind the retina. ^Presbyopia is a physiological change in which there is progressive loss of the accommodative power of the eye as age advances.* Chalazion is a tumor in the eyelid, due to obstruction of the duct in a Meibomian gland. 2. Etiology: Irritation, a foreign body, cold, exposure to strong light or heat, eyestrain. Symptoms: Hyperemia, lacrymation, epiphora, discharge, photophobia, sensation of sand in the eye. Treatment : Remove cause; use astrin- gent and antiseptic washes ; anoint the lids with vaseline. When it becomes contagious, its common name is "pink eye." 3. Ophthalmia neonatorum. Causes: The gonococcus or some other pyogenic microorganism ; the secretions of the mother contain the infecting agent, and transmission may occur directly during parturition, or indirectly by the fingers of physician or nurse, cloths, instruments, etc. Symptoms: Swollen eyelids, with copious purulent dis- charge; ulceration of the cornea may ensue. Prophylaxis: Whenever there is the possibility of infection, or in every 721 MEDICAL RECORD case, wash the eyelids of the newborn child with clean warm water, and drop on the cornea of each eye one drop of a i per cent, solution of nitrate of silver, immediately after birth. Treatment: Wash the eyes carefully every half hour with a saturated solution of boric acid; pus must not be allowed to accumulate. Two drops of a 2 per cent, solution of nitrate of silver must also be dropped on to the cornea every night and morning. The eyes must be covered with a light, cold, wet compress. The patient must be isolated, and all cloths and compresses used must be burnt. OTOLOGY. 1. (1) Insects, by warm water or chloroform oil; (2) by syringing; (3) wax may be removed by disintegrating it with hydrogen dioxide, followed by warm water irrigation. 2. Etiology: Infection from nasopharynx or ear, exan- themata, grippe. Symptoms: Tenderness, pain, swelling and redness over the mastoid ; bulging of the superior and posterior parts of the auditory canal ; temperature variable, from normal up to about 104 F. Treatment: Hot water, or cold water, or ice; leeches, purgatives; light diet ^in- cision or mastoid operation. Three common and serious results: Meningitis, sinus phlebitis, abscess of the brain. STATE BOARD EXAMINATION QUESTIONS. Board of Medical Examiners of the State of Washing- ton. ANATOMY. 1. Name muscles attached to the great trochanter of the femur. 2. Into what two classes are muscles divided? Describe each. 3. Describe Poupart's ligament; name anatomical rela- tions and what passes beneath it. 4. Name the twelve pairs of cranial nerves. 5. Name bones articulating with humerus. 6. Describe diaphragm, its principal openings and nerve supply. 7. What forms the internal hamstring? 8. What constitutes the brachial plexus ? 9. Name the cranial nerve having greatest distribution. 10. Locate and describe Peyer's glands. 11. Name the nerves of the eyeball. 12. Describe the spinal column, special and peculiar vertebra. PHYSIOLOGY. 1. Describe how nature stops the flow of blood from a wound, and tell how you would assist her. 722 MEDICAL RECORD. 2. What is meant by "physiological leucocytosis," and under what conditions found? 3. What is the difference between lymph and serum? Is the former a product of the lymphatic glands? 4. Name at least four functions of the liver. 5. Explain anabolism and katabolism. 6. How can we afford the greatest voluntary assistance to the entrance of venous blood into the heart? 7. Give the nervous control of the heart. 8. What do you understand by "phagocytosis" ? 9. Describe the pancreatic juice, giving the ferments and their specific action. 10. What is food? Classify and give its function. 11. Compare the path followed by a motor nerve im- pulse passing to a skeletal muscle with that of an impulse which reaches an involuntary muscle. 12. Give various causes for the flow of saliva. CHEMISTRY AND TOXICOLOGY. (Answer ten questions only.) 1. Give two tests for albumin in urine. What is the spe- cific gravity of normal urine, and how is it determined? 2. How would you test for sugar in urine that is strongly acid? Which kind of sugar is reduced in the test? 3. Give methods of detecting bile in urine. 4. What are the active principles in saliva, gastric juice, pancreatic juice? What is their chemical function in diges- tive economy? 5. What substances may be present in a good drinking water? What substances would you consider harmful or undesirable? 6. Give the chemical composition of pure air. In respi- ration, what is inhaled and what is exhaled? How do the gases enter and leave the body? 7. What is the poison in (a) paris green? (b) in "rough on rats"? Differentiate between poisoning by arsenic and phosphorus. 8. Give antidotes for poisoning by belladonna, corrosive sublimate, and carbolic acid. 9. What are ptomains? When would you suspect pto- main poisoning? What is the cause of milk and ice cream poisoning? 10. W T hat parts of the body would you prepare for the toxicological chemist, and how? 11. What is the poison in most headache powders? Its effect? Antidote? 12. A patient has died in convulsions; poison is suspected. What poisons might be looked for? 723 MEDICAL RECORD. HISTOLOGY. (Answer ten questions only.) i. Describe the blood. 2. Give the histological structure of a nerve. 3. Describe cartilage and name varieties. 4. Differentiate the histological structure of arteries and veins. 5. Name and describe the membranes of the brain and give function of each. 6. Differentiate white fibrous tissue and yellow elastic tissue as to structure and function. 7. Describe a red blood corpuscle. Where do they have their origin? 8. Give the histological structure of the human skin. 9. Describe normal urine. 10. Give the histological structure of the walls of the stomach. 11. Describe the microscopic appearance of the liver in a healthy adult. 12. Name three types of epithelium and give location of each. GENERAL DIAGNOSIS. 1. What is the normal position of the apex beat, and how is it affected by disease of the heart? What are the two kinds of cardiac murmurs? Name and define the areas over which they are best heard. 2. Define acute anterior poliomyelitis. Give pathology, symptoms, prognosis, and differential diagnosis. 3. Describe a fracture of the upper third of the humerus in a patient at fifteen years of age, and distinguish from other conditions in this region following trauma. 4. Give the differential diagnosis between iritis, corneal ulcer, and conjunctivitis. Give the causes and sequelae of each. 5. Give the symptomatology of tuberculosis of the kidney and the differential diagnosis between it and renal calculus, hydronephrosis, and pyelitis. 6. Give definition of acute osteomyelitis, the pathology, symptomatology, and differential diagnosis between it and acute rheumatism. 7. Give the symptoms and physical signs of broncho- pneumonia and differentiate from lobar pneumonia and bronchitis. 8. Name the varieties and give the signs of dislocation of the head of the radius, and exclude other conditions about the elbow following an injury. 9. In syphilis, when is the cerebral involvement usually manifested? What structures are involved? Give the symptoms, sequelae, and differential diagnosis. 724 MEDICAL RECORD. io. Give the pathology and symptoms of intussusception, and differentiate this condition from volvulus, fecal impac- tion, appendicitis, and mesenteric thrombosis. ii. Give the period of incubation, describe the rash of scarlet fever, and differentiate from other eruptions simu- lating it. What are the most frequent complications and sequelae of this disease? 12. Trichiniasis ; describe the parasite, its habitat, and mode of infection. Give the symptoms and prophylaxis. PATHOLOGY. {Answer ten questions only.) i. Describe the macroscopic and microscopic appearance of an epithelioma of the lip. 2. Describe the pathological changes in a case of cerebro- spinal meningitis. 3. Name varieties of casts found in the urine, and give their clinical significance. 4. Define anemia, hyperemia, leukemia, and leukopenia. 5. What pathological changes usually take place in chronic inflammation of the bones? 6. What is (a) an embolus, (b) a thrombus, (c) an in- farct? 7. Describe the formation of an acute abscess. 8. Differentiate sarcoma and carcinoma, and give diag- nostic pathology of each. 9. State by what two methods the tubercle bacillus pro- duces its specific tissue changes. 10. Give pathology of locomotor ataxia. 11. Name the intestinal lesions of typhoid fever, and give pathology of each. 12. Name stages of syphilis, and give their pathology. OBSTETRICS. i. Name and define the five principal diameters of the fetal head. Tell which is the longest and which plane in a normal labor is in relation to the successive planes of the pelvis. 2. What is meant by placenta praevia? What are the types, symptoms, physical signs, and dangers? 3. What is eclampsia? Give its etiology, symptomatology (both prodromal and during the attack), and diagnosis. 4. Define the term puerperium. Name and give the causes of the principal pathologic processes that may affect the mother during that period. 5. Name and give the causes of the principal disease, both hereditary and acquired, which may affect the new- born infant. 725 MEDICAL RECORD. 6. Give the mode of onset and symptoms of a puerperal infection, and discuss the prognosis. 7. How would you diagnose a left sacroposterior posi- tion, and what are the dangers of the delivery? 8. What do you mean by the mechanism of the second stage of labor? What are the various movements in a normal labor? Discuss each briefly. 9. Describe the changes in nutrition, digestion, urine, and nervous system which may occur in a normal pregnancy. 10. From what conditions would you have to diagnose a pregnancy at the end of the third month? Give the symp- toms and signs of pregnancy at that time, and give the dis- tinguishing features in each case. 11. Define presentation, position, and posture. Give each in normal labor, and tell what causes are most liable to modify each and so cause an abnormal labor. 12. Define menstruation, ovulation, placenta, chorion, amnion, allantois, decidua vera, meconium, caput succe- daneum, cephalhematoma. GYNECOLOGY. 1. Name the contents of the female pelvis; their normal positions and relations. 2. Give anatomy of floor of pelvis and the results of its destruction. 3. State the uterine displacements most commonly met. Give their chief clinical symptoms. 4. Give some of the most common causes of menor- rhagia and metrorrhagia — local, constitutional, and vas- cular. 5. Gonorrheal infection in the female, acute and latent; give parts involved, symptoms objective and subjective, and other diagnostic methods; give dangers immediate and remote of the disease. 6. Give hygienic regulations for girl at puberty. 7. Give etiology of sterility in the female. 8. Give causes of pruritus vulvae. 9. Differentiate extrauterine pregnancy from appendi- citis and salpingitis. 10. Give effects on general health by fibroid tumors; their subjective symptoms, prognosis, and degenerative changes that may occur. 11. Give diagnostic signs and symptoms of cancer of the fundus of the uterus, and from what is it to be differen- tiated ? 12. From what is a large ovarian cyst to be differen- tiated, and how done? 726 MEDICAL RECORD. HYGIENE. (Answer ten questions only.) i. Give a few important rules for the care and control of tuberculosis. 2. What are the methods of transmission of the more important infectious and contagious diseases? Give illus- trations of each. 3. What are the most common sources of infection in diphtheria, and what hygienic precautions should be em- ployed ? 4. W T hat measures would you employ for the prevention of the spread of contagious diseases? 5. Differentiate between endemic and epidemic diseases. 6. Through what media is the typhoid infection usually communicated? 7. What gases are most efficient as disinfectants? 8. How would you disinfect (1) rooms, (2) clothing, (3) hands, (4) urine and feces, water closets, etc.? 9. What diseases are incident to school life, and how prevented? 10. What are (a) toxins, (b) antitoxins? 11. If a chemical analysis of water revealed the presence of nitrites and nitrates, would this condemn it for drink- ing? If so, why? 12. Mention the principal diseases that should be quaran- tined? And how would you determine the length of time in each? ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Board of Medical Examiners of the State of Washing- ton. ANATOMY. 1. Gluteus medius, gluteus minimus, pyriformis, obturator externus, obturator internus, superior gemellus, inferior gemellus. 2. Striated, unstriated, and cardiac. See Gray's "Anat- omy" (1908), page 363. 3. See Cunningham's "Anatomy" (1909), page 422; or, Gray's "Anatomy" (1908), page 438. 4. The twelve pairs of cranial nerves are: (1) Olfactory. (2) Optic. (3 Motor oculi. (4) Trochlear or Pathetic. (5) Trifacial. (6) Abducens. (7) Facial. (8) Auditory (g) Glossopharyngeal. (10) Pneumogastric or Vagus. (11) Spinal Accessory. (12) Hypoglossal. -5. Scapula, ulna, and radius. 727 MEDICAL RECORD. 6. The diaphragm is a musculofibrous septum which di- vides the thoracic from the abdominal cavity; it is fan- shaped; the broad, elliptical portion is horizontal, and the crura are vertical. It is attached to the ensiform, to the internal surfaces of the lower six costal cartilages, to bodies and intervertebral substances of first, second, and third lumber vertebrae. Its openings are: (i) The aortic, (2) the esophageal, (3) the opening for the vena cava, (4) the right crural, (5) the left crural. Nerve supply: Phre- nic, lower intercostal, and sympathetic. 7. The tendons of the Semimembranosus, Semitendi- nosus, Gracilis, and Sartorius. 8. The brachial plexus is formed by the union and subse- quent division of the anterior divisions of the fifth, sixth, seventh, and eighth cervical and the first dorsal nerves. The union of the fifth and sixth makes the upper trunk ; the seventh forms the middle trunk, and the eighth cervical and first dorsal make the lower trunk. Each of these trunks is divided into an anterior and a posterior branch. The anterior branches, from the upper and middle trunks, make the upper or outer cord of the plexus ; the anterior branch of the lower trunk becomes the lower or inner cord ; the three posterior branches unite to form the posterior or middle cord. The plexus lies between the Scalenus anticus and medius. 9. The tenth, or pneumogastric. 10. See Cunningham's -"Anatomy" (1909), page 1064; or, Gray's "Anatomy" (1908), page 1304. 11. Sensory, from branches of the first division of the fifth cranial nerves ; motor, from third, fourth, and sixth cranial nerves. 12. See Cunningham's "Anatomy" (1909), pages 88, 75, 79, etc.; or, Gray's "Anatomy" (1908), pages 67, 50, etc. PHYSIOLOGY. 1. Nature's way of stopping the flow of blood from a wound is by the coagulation of the blood. This may be helped by anything that aids coagulation, such as styptics or the application of gauze, bandages, etc. 2. Physiological leucocytosis is an increase in the number of the white blood corpuscles occurring under normal or physiological conditions, such as : Digestion, exercise, after a cold bath, or during pregnancy. 3. Lymph is diluted blood without the red corpuscles; serum is practically blood plasma, with the exception of the substances which enter into the formation of fibrin. Lymph is not a product of the lymphatic glands. 4. The functions of the liver are: (1) The secretion of bile; (2) the formation of glycogen; (3) the formation of urea and uric acid; (4) the manufacture of heat, and (5) 728 MEDICAL RECORD. the conversion of poisonous and harmful into inert material. 5. Metabolism is the entire series of changes that occur in a cell or organism during the processes of nutrition. It is of two kinds : (1) Assimilative, or constructive (anabol- ism), and (2) destructive (katabolism). 6. By taking deep inspirations. 7. The nerves which control the heart are: (1) The pneumogastric nerve, which slows or inhibits the heart beats; (2) the sympathetic nerves, which accelerate or aug- ment the beats; and (3) the intrinsic cardiac ganglia, which enable the heart to continue beating for some time after it is removed from the body. 8. Phagocytosis is the faculty of certain cells (notably the mononuclear and polynuclear leucocytes) to take up and destroy bacteria. 9. The pancreatic juice is a colorless, viscid, odorless, salty fluid, alkaline in reaction, and of a specific gravity of about 1030. Composition: Water and solids, the latter con- sisting of three enzymes (trypsin, amylopsin, and steap- sin), proteid material, soaps, fats, lecithin, and inorganic salts (carbonate of sodium, chloride of sodium, and phos- phates of sodium, calcium, and magnesium). Ferments: (1) trypsin, which changes proteids into pro- teoses and peptones, and afterward decomposes them into leucin and tyrosin ; (2) amylopsin, which converts starch into maltose; (3) steapsin, which emulsifies and saponifies fats ; and (4) a milk-curdling ferment. All of these act in an alkaline medium only. 10. Food is material which, after being taken into the body, is capable of building up the body, of repairing tissue waste, and of supplying heat and energy. Foods are classi- fied as : T T . ( Water. I. Inorganic. J Salts> tt Dr^n,v 1 Nitrogenous — Proteids. f ~ . , , li. Organic ' ° f Carbohydrates. I Aon-Jsitrogenous. jp * Function of proteids: Formation and repair of tissues and fluids of the body, regulation of the absorption and utilization of oxygen, formation of fats and carbohydrates, production of energy. Function of carbohydrates: Produc- tion of heat and energy, and formation of fats. Function of fats: Supply of heat and energy, supply of fatty tissues, nutrition of nervous system. Function of salts: Support of bony skeleton, supply of HC1 for digestion, regulation of nutrition and energy. Function of water: It enters into the composition of all the tissues and fluids of the body, it moistens the surfaces and membranes of the body, it keeps the fluids of the body at their proper degree of dilution, it 729 MEDICAL RECORD. removes waste matters, distributes and regulate body heat. ii. To a skeletal muscle the motor nerve impulses start in the cortex cerebri, and pass through the corona radiata, internal capsule, crus, pons, medulla, crossed and direct pyramidal columns to motor cells of anterior horn of spinal column, thence through nerve root and motor nerve to muscle. To involuntary muscle: The efferent fibers of the sympathetic nervous system arise in the intermedio- lateral column of gray cells. They pass out by the anterior root from the spinal chord. From here they go by a white ramus to a sympathetic ganglion. From the sympathetic ganglion they may pass in two directions: (i) they may form synapses about these cells and from these cells new axons may arise and pass outwards in the visceral nerves, or back through the gray ramus connected to the ganglion, into the spinal or somatic nerve to the blood-vessels as vasomotor nerves, or sweatglands as secretory nerves, or to hairs as pilomotor nerves; (2) or they may pass through the ganglion on to one situated more towards the periphery, in which they form synapses and are continued onward by new axons." 12. Causes of How of saliva: The taste, sight, or smell of food ; the hearing of sounds associated with the prepara- ton of food, various drugs (sialagogues), section of chorda tympani, or stimulation of its peripheral end when divided; section of sympathetic nerves supplying the sali- vary glands, or stimulation of the peripheral end, when divided; the thought of savory food; the feeling of nau- sea which precedes vomiting. CHEMISTRY AND TOXICOLOGY. I. TWO TESTS FOR THE DETECTION OF ALBUMIN IN THE urine: "The urine must be perfectly clear. If not so, it is to be filtered, and if this does not render it transparent it is to be treated with a few drops of magnesia mixture and again filter ed." I. — The heat test: "The reaction is first observed. If it be acid, the urine is simply heated to near the boiling point. If the urine be neutral or alkaline, it is rendered faintly acid by the addition of dilute acetic acid and heated. If albumin be present, a coagulum is formed, varying in quantity from a faint cloudiness to entire solidi- fication, according to the quantity of albumin present. The coagulum is not redissolved upon the addition of HNO*." II. — Heller's modification of the nitric acid test: "Place in a test-tube a layer of HN0 3 about 2 c. in thickness; then with a pipette, carefully float upon the surface of this a layer of the urine in such a manner that the liquids do not mix. If albumin be present, a cloudy ring appears at the point of junction of the two layers, the borders of the cloud being sharply defined. A cloudy ring may be formed 730 MEDICAL RECORD. by the presence of an excess of urates, but in this case it is not at, but above, the point of junction of the layers, and its upper border is not sharply defined, but fades off grad- ually." (Witthaus' Essentials of Chemistry.) The specific gravity is about 1015 to 1025, and is deter- mined by means of a urinometer. 2. Boettger's test for sugar: Render the urine strongly alkaline by addition of Na 2 C0 3 . Divide about 6 c.c. of the alkaline liquid in two test-tubes. To one test-tube add a very minute quantity of powdered subnitrate of bismuth, to the other as much powdered litharge. Boil the contents of both tubes. The presence of glucose is indicated by a dark or black color of the bismuth powder, the litharge retaining its natural color. The kind of sugar reduced is glucose. 3. Test for bile pigment in the urine: Put 3 c.c. HNO* in a test-tube ; add a piece of wood, and heat until the acid is yellow; cool. When cold, float some of the urine to be tested upon the surface of the acid. A green band is formed at the junction of the liquid, which gradually rises, and is succeeded from below by blue, reddish-violet, and yellow. 4- SECRETIONS Sal iva Gastric juice. Pancreatic juice ACTIVE PRINCIPLES Ptyalin. Pepsin. ^A curdling f e! ment. Tiypsin. Amylopsin. Steapsin. A curdling L ferment. FUNCTION. Changes starches into dextrin and sugar. Changes proteids into proteoses and peptones in an acid medium. Curdles the casein of milk. Changes proteids into proteoses and peptones, and afterward decom- poses them into leucin and tyrosin ; in an alka- line medium. Converts starches into maltose. Emulsifies and saponifies fats. Curdles the casein of milk. 5. Good drinking water may contain the following in very small amounts : Free ammonia, albuminoid ammonia, nitrogen as nitrates, nitrogen as nitrites, and chlorine. Harmful or undesirable substances would include all the above in larger quantities, and the following: Sewage, leaves, surface washings, manufacturing refuse, lead, other 731 MEDICAL RECORD. metals, leakage from gas pipes, insects, fungi, bacteria, entozoa. 6. Oxygen , Nitrogen Carbon dioxide. Other gases Watery vapor. . Temperature . . , Volume , Bacteria Dust INSPIRED AIR 21 per cent. 79 per cent. 0.04 per cent. Rare. Variable. Variable. Varies. Always present. Always present. EXPIRED AIR. 16.6 per cent. 79 per cent. 4.4 per cent. Often present. Saturated. That of body. Diminished. None. None. The gases enter and leave the body by the process of diffusion, or differences in pressure in the alveoli of the lungs. 7. The poison in Paris green is arsenic; in Rough on Rats, is phosphorus. Arsenic: The symptoms usually begin in from twenty to forty-five minutes ; nausea and f aintness ; violent, burning pain in the stomach, which becomes more and more intense, and increases on pressure. Persistent and distressing vomiting of matters, sometimes brown or gray, or streaked with blood, or green (Paris green) ; purg- ing ; more or less severe cramps in the lower extremities. Phosphorus: Eructation of gas having the odor of garlic. The mouth, when observed in the dark, is frequently faintly luminous (phosphorescent). After several hours, pain in the throat, a sense of heat in the epigastrium, nausea, and vomiting. The vomited matters are sometimes bloody, and frequently luminous when agitated in the dark. The abdomen is tender, and there are diarrhea and colicky pains. After one or two days these symptoms cease, there remaining only pain in the back and limbs and a feeble pulse. Death sometimes occurs suddenly in from two to four days. Usually about the fourth day the patient becomes jaundiced, suffers from headache, insomnia, and retention of urine, rapidly becomes delirious and comatose, and dies. (From Witthaus' Essentials of Chemistry and Toxicology.) 8. Antidote for belladonna, none; pilocarpine and mor- phine are often given. For corrosive sublimate, milk or white of Qgg in moderate quantity, followed by an emetic. For carbolic acid, a soluble sulphate, such as sodium or magnesium sulphate, or alcohol. 9. Ptomains are basic nitrogenous compounds, produced from protein material by the bacteria which cause putre- faction. They are found in protein foods which have partly undergone decomposition. Ptomain poisoning. Symptoms: Chilliness, headache, vertigo, muscular twitchings, halluci- 732 MEDICAL RECORD. nations, imperfect vision, weak and rapid pulse, nausea, vomiting, diarrhea, cyanosis, early dyspnea, often subnor- mal temperature, and occasionally cutaneous eruptions. The cause of milk and ice-cream poisoning is tyrotoxicon. 10. In case of suspected homicidal poisoning, the follow- ing parts of the cadaver should be preserved : "The ali- mentary canal from the cardia to the middle of the rec- tum, unopened, and the contents enclosed by ligatures at the esophagus, duodenum, and lower end of gut; the liver, including the gall-bladder; one kidney; the spleen; a piece of muscular tissue from the leg; the brain, and any urine which may remain in the bladder. "They are to be placed in clean and new glass jars, closed with glass or cork covers or stoppers. Jars with metallic caps should never be used. Tapes or cords should be tied about the jar and cap, to which they should be attached by sealing wax bearing impressions of a seal, in such a man- ner that access can only be had to the interior after break- ing the seals or cutting the tapes or cords. Great care must be exercised that no sealing wax can get into the jars. Each portion should be placed in a jar by itself." (Witthaus' Essentials of Chemistry.) ii. Acetanilide. Effect: Chilliness, cold sweat; nausea; pulse is soft, slow, and feeble; respirations slow and shal- low. Treatment: Lavage, diffusible stimulants, application of heat, coffee or strychnine, inhalation of oxygen, or saline infusion. 12. Convulsions occur in poisoning by : Strychnine and picrotoxin. HISTOLOGY. 1. The blood is a fluid somewhat viscid, red, specific gravity from 1055 to 1062, alkaline reaction, saltish taste, characteristic odor, variable temperature (average about ioo° F.) The constituents of the blood are plasma and corpuscles. The plasma consists of water and solids (pro- teids, extractives, and inorganic salts). The red corpuscles consist of water and solids (hemoglobin, proteids, fat, and inorganic salts). The white corpuscles consist of water and solids (proteid, leuconuclein, lecithin, histon, etc.). There are also platelets, which are very small, colorless, irregular shaped bodies, about one-fourth the size of the red corpuscle. 2. See Cunningham's "Anatomy" (1909), page 444; or, Gray's "Anatomy" (1908), page 819. 3. Cartilage is a form of connective tissue; it is firm and elastic; opaque, and of a bluish color. The varieties are: (1) Hyaline, in which the cells are relatively few and are imbedded in a quantity of ground substance. (2) White fibro cartilage, in which the ground substance contains 733 MEDICAL RECORD. bundles or layers of white fibers, between which are en- capsulated cells. (3) Yellow fibro cartilage, in which the ground substance contains a network of yellow, elastic fibers, and the cartilage cells are in the meshes of this net- work. 4. See Cunningham's "Anatomy" (1909), page 781; or, Gray's "Anatomy" (1908), page 586. 5. See Cunningham's "Anatomy" (1909), page 597; or, Gray's "Anatomy" (1908), page 972. 6. The function of the dura is protection : It forms the internal periosteum of the skull ; it forms three partitions for the support of the parts of the brain; it forms sinuses or venous channels for the return of the blood from the brain, and it forms sheaths for the nerves as they leave the skull. The function of the arachnoid is lymph supply; of the pia, blood supply and nutrition. 7. The red blood corpuscles are biconcave discs, about 1-3200 of an inch in diameter; they are nonnucleated, and there are about 4,500,000 or 5,000,000 of them in each cubic millimeter of blood. They are elastic and soft, and their shape is changed by pressure, but is promptly regained on the removal of the pressure. Their color is yellowish. They contain hemoglobin. They originate in the marrow of the long bones. 8. See Cunningham's "Anatomy" (1909), page J72; or, Gray's "Anatomy" (1908), page 1190. 9. Normal urine is a straw- or amber-colored fluid, with specific gravity from about 1015 to 1025; its chemical reac- tion is acid. The normal constituents are : Water urea, uric acid, urates, hippuric acid, kreatin, kreatinin, xanthin, hypoxanthin, sulphates, chlorides, and phosphates of sodium and potassium; phosphates of magnesium and cal- cium, nitrogen and carbon dioxide. The average quantity voided in twenty-four hours is about fifty ounces. 10. See Cunningham's "Anatomy" (1909), page 1058; or, Gray's "Anatomy" (1908), page 1281. 11. See Cunningham's "Anatomy" (1909), page 1121; or, Gray's "Anatomy" (1908), page 1345. 12. (1) Columnar epithelium; in stomach, intestines, and ducts of most secreting glands. (2) Cubical epithelium ; in thyroid, testis, and some of the glands. (3) Ciliated epithe Hum ; in upper air passages, Fallopian tubes, ventricles of brain, Central canal of spinal cord, vasa efferentia, and tail of spermatozoa. GENERAL DIAGNOSIS. I. The apex beat is normally in the fifth left intercostal space, about three inches to the left of the midsternal line. It may be displaced (upward, downward, to left, to right; the impulse may be increased, weakened, or absent; the 734 MEDICAL RECORD. frequently may be increased or decreased; the extent may vary). The two kinds of cardiac murmurs are: (i) Hemic, and (2) Organic. The former is heard best over the base ; the latter, generally over the apex or sternum, sometimes at base (the exact location varying with the valve affected). 2. See French's "Practice" (1907), page 1034; or, Osier's "Practice" (1909), page 914. 3. See Rose and Carless' "Surgery" (1908), page 5502; or, Da Costa's "Surgery" (1908), page 486. 4. CONJUNCTIVITIS 1. No change in iris. 2. Pupil normal. 3. Anterior chamber nor- mal. 4. Conjunctival injection, coarse meshes, most pro- nounced in fornix and fad- ing toward the cornea. 5. Mucous or mucopuru- lent secretion. 6. Discomfort, but no real pain. 7. Conjunctiva reddened and opaque. 8. No interference with vision. iritis 1. Discolored and altered iris. 2. Pupil small, gray, slug- gish, irregular after use of atropine. 3. Exudation in anterior chamber. 4. Ciliary (circumcorneal) injection; pink zone of fine vessels surrounding cornea and fading toward fornix. 5. ^ Lacrymation, but no se- cretion. 6. Pain, worse at night. 7. Conjunctiva usually transparent. 8. Vision diminished in acuteness. Conjunctivitis. Causes: Foreign body, irritation, heat or cold, exposure to light, eyestrain, infection. Sequela: Scars, ulceration, perforation, staphyloma. Iritis. Causes: Syphilis, gout, rheumatism, tuberculosis, diabetes, nephritis, infections, traumatism, inflammations. Sequela: Opacities, synechias Corneal ulcer. Causes: Traumatism, extension of inflammation. Diagnosis : It is detected by oblique illu- mination, the ophthalmoscope, or convex lens, and by dropping fluorescin upon the cornea, the denuded area be- ing colored green. Pain, photophobia, lacrimation^ swelling of the lids and conjunctiva, and destruction of tissue are symptoms. Sequela: Corneal opacities, staphyloma, per- foration, adherent leukoma, atrophy of the eyeball, and prolapse of the lens and vitreous. 5. See French's "Practice" (1907), pages 383, 911, 910, and 907; or, Osier's "Practice" (1909), pages 346, 710, 707 and 704. 735 MEDICAL RECORD. 6. See Rose and Carless' "Surgery" (1908), page 570; or, Da Costa's "Surgery" (1908), page 440. In acute rheuma- tism there is successive involvement of many joints; the tenderness, pain, and swelling are over the joints, and not over the bones; profuse sweats are present, and the condi- tion responds to treatment by salicylates. 7. See French's "Practice" (1907), page 672; or, Osier's "Practice" (1909), page 624. 8. See Rose and Carless' "Surgery" (1908), page 625; or, Da Costa's "Surgery" (1908), page 594. 9. See French's "Practice" (1907), page 423; or, Osier's "Practice" (1909), page 271. 10. See French's "Practice" (1907), page 799; or, Osier's "Practice" (1909), page 519; or, Rose and Carless' "Sur- gery" (1908), pages 1 1 19 and 1123; or, Da Costa's "Sur- gery" (1908), page 837. n. See French's "Practice" (1907), page 315; or, Osier's "Practice" (1909), page 130. 12. See French's "Practice" (1907), page 492; or, Osier's "Practice" (1909), page 39. PATHOLOGY. 1. See Rose and Carless' "Surgery" (1908), pages 211 and 801. 2. See French's "Practice" (1907), page 141; or, Osier's "Practice" (1909), page 159. 3. Hyaline casts occur in all forms of nephritis, in con- gestion of the kidneys, in jaundice; waxy casts, in chronic parenchymatous nephritis; epithelial casts, in acute paren- chymatous nephritis ; granular casts, in chronic nephritis and in acute nephritis ; fatty casts, in cnronic parenchy- matous nephritis; blood casts, in hemorrhagic nephritis; pus and bacterial casts, in suppurative nephritis. 4. Anemia denotes a condition in which there is reduction of the quantity or quality of the blood (generally used with reference to the red corpuscles). Hyperemia denotes ex- cessive blood in a part. Leukemia is a condition in which the white blood corpuscles are increased in number, and is accompanied by pathological changes in the spleen, lym- phatic glands, and bone marrow. Leukopenia is a condition in which the number of white blood corpuscles in the peripheral circulation is below the normal. 5. See Rose and Carless' "Surgery" (1908), page 57& 6. An embolus is a plug in a blood vessel brought thither by the blood current. A thrombus is a blood clot formed in the blood vessels during life. An infarct is an area of tissue in which, owing to the plugging up of an end artery or terminal artery, nutrition is prevented. 7. See Rose and Carless' "Surgery" (1908), page 627; or, Da Costa's "Surgery" (1908), page 132. 736 MEDICAL RECORD. 8. Carcinoma is apt to occur at a later age ; is found in structures derived from the epiblast or hypoblast; pos- sesses a fibrous stroma, in which are found both blood vessels and lymphatics ; metastasis is by the lymphatics. Sarcoma is apt to occur earlier; is found in structures derived from the mesoblast; there is no stroma between the cells ; the blood vessels are in direct contact with the tumor cells; there are no lymphatics; metastasis is by the blood vessels. 9. Irritation and degeneration. 10. In locomotor ataxia the posterior columns of the spinal cord and the posterior nerve roots are 'involved The posterior columns of the spinal cord are gray and shrunken, and show considerable overgrowth of connective tissue in the columns of Goll, Burdach, and Lissauer; this process extends upward from the lumbosacral region; the posterior nerve roots degenerate and become atrophic. The meninges over the affected parts become opaque and adhe- rent. Some of the cranial nerves may also atrophy, notably the optic, but also the motor oculi and vagus. The process is destructive and progressive ; it is not a simple wasting, although the nerve fibers are atrophied, but it is characterized by irritation, changes in the axis cylin- ders, overgrowth of the connective tissue, and sometimes congestion ; the spinal ganglia may be affected. 11. See French's "Practice" (1907), page 85; or, Osier's "Practice" (1909), page 65. 12. See French's "Practice" (1907), page 420; or, Osier's "Practice" (1909), page 267. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), page 153; or, Hirst's "Obstetrics" (1909), page 92. 2. See Williams' "Obstetrics" (1909), page 809; or, Hirst's "Obstetrics" (1909), page 572. 3. See Williams* "Obstetrics" (1909), page 524; or, Hirst's "Obstetrics" (1909), page 628. 4. See Williams' "Obstetrics" (1909), pages 332 and 851; or, Hirst's "Obstetrics" (1909), pages 347 and 644. 5. See Williams' "Obstetrics" (1909), page 599; or, Hirst's "Obstetrics" (1909)* page 155. 6. See Williams' "Obstetrics" (1909), page 852; or, Hirst's "Obstetrics" (1909), page 712. 7. See Williams' "Obstetrics" (1909), page 284; or, Hirst's "Obstetrics" (1909), page 419. 8. See Williams' "Obstetrics" (1909), page 256; or, Hirst's "Obstetrics" (1909), page 396. 9. See Williams' "Obstetrics" (1909), page 173; or, Hirst's "Obstetrics" (1909), page 186. 737 MEDICAL RECORD io. See Williams' "Obstetrics" (1909), page 190; or, Hirst's "Obstetrics" (1909), page 204. 11. See Williams' "Obstetrics" (1909), pages 205 and 207; or, Hirst's "Obstetrics" (1909), page 388. Posture is the altitude of the fetus in the uterus. 12. Menstruation is a periodical disturbance in the female characterized by a bloody mucous discharge from the uterine cavity ; it lasts during the period of woman's sexual activity, but is temporarily suspended during pregnancy and early lactation. Ovulation is the development and ripening of ovules in the ovary and their discharge therefrom. Placenta is an organ on the internal wall of the pregnant uterus, to which the fetus is attached by means of the umbilical cord. Chorion is the outermost of the three fetal membranes. Amnion is the innermost of the fetal mem- branes. Allantois is one of the fetal membranes, which enters into the formation of the true chorion and the pla- centa. Decidua vera is that portion of the decidua (or hypertrophied mucous membrane) which lines the uterine wall during pregnancy. Meconium is the greenish-black stools of the newborn infant; it consists of intestinal mucus, bile, epithelium, vernix caseosa, cholestrin, phos- phates, and fat. Caput succedaneum is the edematous swell- ing developed on the presenting part of the fetus during birth. Cephalhematoma is a swelling occurring on the head of a newborn infant, due to subpericranial hemorrhage. GYNECOLOGY. 1. See Cunningham's "Anatomy" (1909), page 1181, etc.; or, Gray's "Anatomy" (1908), pages 1440, 1498, etc. 2. The pelvic floor is composed chiefly of fascia, muscles, and connective tissue. Its superior surface is lined by peri- toneum. Next below, and in close contact with the peri- toneum, comes the "internal pelvic fascia." Immediately below the internal pelvic fascia are two thin muscles, viz. : (1) The levator ani, each half of which arises from the body and horizontal ramus of the pubes and from the arcus tendineus, and passes downward ana inward to meet its fellow of the opposite side in the median line, where it is inserted into a tendinous raphe extending from the coccyx to the rectum, while some fibers pass between and to the sides of the bladder and rectum, and to the vaginal and rectal sphincters. (2) The coccygeus t which is a narrow, triangular slip, situated parallel with and posterior to the levator ani, closing in a little space which the latter muscle failed to cover. Below these muscles the pelvic floor is further strengthened by the perineal fascia. Its posterior portion consists of a single layer, while its anterior part is divisible into three layers. Within these latter layers are lodged the pudic vessels and nerves, and the superficial 738 MEDICAL RECORD muscles of the perineum. These muscles are the constrictor vagina, the sphincter ani, and the transversus perinei, and to these structures must be added the integument and the very numerous interstitial layers of elastic connective tis- sue, which latter weld the parts together and add strength and elasticity to the whole fabric. — (From King's Obstet- rics.) "Tears of the perineum destroy the integrity of the pelvic floor and result eventually in rectocele, cystocele, hemor- rhoids, and displacements of the pelvic organs. If the tear involves the sphincter ani, incontinence also results. Lacer- ations of the cervix retard or check involution of the uterus and predispose to endometritis, menorrhagia, displacements, eversion of the cervical mucous membrane, cystic degen- eration, and malignant disease. Deep lacerations of the vaginal vault may open into the base of the broad ligaments, and in the majority of instances genitourinary fistulas are caused by traumatisms of labor. All lacerations are imme- diately dangerous on account of the increased liability to sepsis, while the remote results are generally due to inter- ference with involution or the pelvic circulation and to the destruction of the normal supports of the pelvis." (Ash- ton's Gynecology.) 3. The common displacements of the uterus are : Retro- version, retroflexion, anteflexion, and descent or prolapse. The following symptoms may follow displacements of the uterus : Backache, bearing-down pains, a feeling of pres- sure in the pelvis, constipation, hemorrhoids, frequent or painful urination, leucorrhea, menstrual disturbances, as dysmenorrhea or menorrhagia, sterility; there may also be general symptoms, as headache, indigestion, nausea, anor- exia, neurasthenia, and general malaise. 4. Common Causes of Menorrhagia. Constitutional: Purpura, scorbutus, hemophilia, hepatic cirrhosis, over in- dulgence in food and alcoholic drinks. Local and Vascular: Uterine congestion and displacement, endometritis, subin- volution, fibroids, and other tumors. Common Causes of Metrorrhagia. Constitutional: None. Local and Vascu- lar: Disease of uterus or appendages, polyps, extrauterine gestation, the hemorrhages in connection with pregnancy. 5. Parts involved are : Vagina, vulva, and urethra ; uterus, tubes, ovaries, peritonenn; rectum. Diagnosis is made by finding the gonococcus characteristically grouped in the cells of the secretion. Symptoms are : Pain, discharge, painful urination, tenderness, redness, inflammation of parts affected. Dangers: Spread of the disease to adjoining parts or tissues, sterility, peritonitis, blindness, and spread of the gonorrhea to others. 6.. Hygiene of Puberty: Constipation must be remedied; 739 MEDICAL RECORD. diet must be nutritious but simple; frequent rest, moderate amusements, and adequate exercise are necessary; the girl should be instructed with regard to menstruation and the menstrual periods; overwork at school, and nervous excit- ability, late hours, and much company should be avoided; books, amusements, and associates should be carefully selected. 7. Etiology of Sterility in the Female: Gonorrhea, absence or errors- in development of any part of the genital tract, malformations of genitals, fistulae, lacerations, obesity, alcoholism, pelvic inflammations, dyspareunia, inflammations of uterus, tubes, or ovaries, elongated cervix. 8. Pruritus vulva may be caused by: Parasites; diseases of the vulva, as inflammation, edema, vegetations, conges- tion; irritating discharges; lack of cleanliness; diabetic urine ; it may also be of nervous origin, or idiopathic. 9. In extrauterine pregnancy, there will be signs of early pregnancy, hypogastric or inguinal pains, probable history of a previous sterility, probable expulsion of decidual mem- brane or shreds, softening of the cervix, enlargement of the uterus, presence of a distended tube, contractions of the wall of the gestation sac; if rupture occurs, there will be sudden, excruciating pains over the lower abdomen and on the affected side, shock, collapse, and symptoms of internal hemorrhage. In appendicitis, there are no signs of pregnancy, there are sudden pain and tenderness in the right iliac fossa, rigidity of right rectus muscle, fever, nausea, vomiting, constipation, no history of menstrual irregularities. In salpingitis, the tubes are inflamed usually secondary to inflammation of uterus or to infection (either gonorrheal or puerperal), backache, pain in lower abdo- men, history of menstrual irregularity, leucorrhea, tube is enlarged and tender. 10. Fibroids. General effect: Health deteriorates from the hemorrhage, pain, leucorrhea, and pressure on neighbor- ing organs; anemia, constipation, loss of weight, edema, and hepatic troubles may ensue. Symptoms: Hemorrhage, leucorrhea, pain, vesical symptoms, hemorrhoids, constipa- tion, and enlargement of abdomen. Prognosis: Variable; fibroids may cease to trouble at the menopause; but they may also degenerate, and they certainly cause much invalid- ism. The prognosis is better after early operation. Degen- erative changes: Fatty mucoid, and cystic degeneration; calcification ; septic infection ; malignant changes. 11. Cancer of fundus of uterus is diagnosed by the pres- ence of tumor, cachexia, hemorrhage, pain, and offensive discharge ; microscopic examination big aid in the diagnosis. It is to be differentiated from: Polypi, fibroids, retained placenta, and chronic endometritis. 740 MEDICAL RECORD. 12. Large ovarian cyst may be differentiated from: Pregnancy, ascites, and possibly uterine tumors. Preg- nancy gives history and signs of the condition. ASCITES 1. Previous history of visceral disease. 2. Enlargement compara- tively sudden. 3. Face puffy ; color waxy; early anemia. 4. Patient on back, en- largement symmetrical; flat in front. 5. Sitting up, abdomen bulges below. 6. Navel prominent and thinned. 7. Fluctuation decidedly clear, diffuse throughout abdomen, but avoids highest parts in all positions, and always has a hydrostatic level. 8. Intestines float on top of fluid; hence percussion gives clear tympanitic note over the highest parts of abdominal cavity, and dul- ness in lowest parts for all positions — i.e. areas of res- onance and dullness change with position. 9. Vaginal touch detects fluctuation, bulging into va- gina. 10. Uterus in prolapsed location, but position un- changed. Size and mobility unchanged. 1 1. Hydragogues and diu- retics temporarily remove the fluid. 12. Fluid light straw color and thin. Coagulates spontaneously. OVARIAN CYST i. No such history. 2. Gradual. 3. Facies ovariana. Ane- mia absent, or later. 4. Asymmetrical until tu- mor is quite large; promi- nent in front. 5. No appreciable change. 6. Navel usually un- changed. 7. Less clear; limited to cyst; not modified by change of position. No hydrostatic level. 8. No change in areas of dullness and resonance with change of position. Dull- ness over cyst. Clear res- onant note in all parts be- yond cyst limits, i.e. in flanks and toward the dia- phragm. 9. Vaginal fluctuation less clear or absent. 10. Uterus displaced for- ward or backward, or later- ally by pressure of cyst. 11. Medicines have no ef- fect. 12. Fluid light or dark and of varying consistency : albuminous, but does not coagulate spontaneously ; may contain colloid matter. (From Dudley's Gynecology.) 741 MEDICAL RECORD. HYGIENE. 1. "The preventive measures which may be taken to reduce tuberculosis may be summarized as follows: (i) The compulsory notification of phthisis. (2) The removal of those conditions of domicile and of occupation which are known to promote the incidence of the disease, includ- ing the regulation of certain dusty trades. (3) The dif- fusion of knowledge (by medical men, leaflets, etc.) regarding the nature and modes of spread of the disease, and the precautions which should be taken in order to pre- vent its extension. (4) The testing of sputum and other suspected discharges, and of milk, meat, etc., supposed to be tuberculous — reports to be furnished free of charge. (5) Local authorities to undertake, without charge, the disinfection of houses recently occupied by phthisical per- sons. (6) The establishment of sanatoria and isolation accommodation for the cure of phthisical patients, and the isolation of those who are a distinct source of danger to fellow lodgers or workers. (7) The enforcement of meas- ures against spitting in public conveyances and in places of public resort. (8) The efficient sanitary supervision of dairy farms, dairies, and milkshops. The periodical vet- erinary inspection and testing (by tuberculin) of milch cows, and the slaughter of tuberculous animals. The pro- hibition of the sale of milk of cows affected with tuber- culosis. (9) The proper inspection of meat in public abattoirs, and the adoption of due precautions for the con- trol of imported meat and milk." (Parkes' Practical Hygiene.) 2. Disease may be transmitted by: (1) Air, as tubercu- losis; (2) Food, as tuberculosis; (3) Insects, as malaria, yellow fever; (4) Milk, as typhoid; (5) Fomites, as measles, scarlet fever; (6) Contact, as syphilis, gonorrhea; (7) Wounds, as tetanus. 3. Diphtheria is conveyed through the air, or by the mouth, and occasionally through wounds. Hygienic pre- cautions should include isolation of the patient, strict antiseptic precautions on behalf of all who come in con- tact with the patient, and fumigation with sulphur or formaldehyde. 4. Isolation ; quarantine ; asepsis and antisepsis ; common sense; cooperation with health boards; vaccination, anti- toxin or other similar prophylactic. 5. Endemic disease is one found in a given locality more or less constantly. Epidemic disease is one which affects a very large part or the whole of a certain community. 6. Food, fingers, flies, milk, water, and "typhoid carriers." 7. Formaldehyde and sulphur dioxide. 8. For disinfection of: (1) Rooms, use formaldehyde 742 MEDICAL RECORD. gas; (2) Clothing, use solution of phenol (5 per cent.) for an hour, then boil for an hour; (3) Hands, wash in soap and water, and immerse in cresol or carbolic acid solution; (4) Urine and feces, etc., should be passed into vessels containing dilute solution of formalin. Water closets, dilute formalin solution. 9. Diseases incident to school life: Measles, scarlet fever, chicken pox, mumps, diphtheria, adenoids, ring- worm, pediculi, myopia, trachoma, strabismus, smallpox, spinal curvature. For prevention see index in French's or Osier's "Practice." 10. Toxins are harmful or poisonous products of bac- teria. Antitoxins are substances formed in the body, of a protective character, and capable of rendering inert the poisonous products of bacteria. 11. Nitrates are generally due to the oxidation of organic matter of animal origin. Nitrites generally indi- cate sewage contamination. The presence of nitrites should condemn the water ; so should a marked amount of nitrates. 12. Quarantinable diseases: Cholera, yellow fever, small- pox, plague, typhus, leprosy, diphtheria, scarlet fever, measles, mumps, chicken pox, erysipelas. For length of time, see index in French's or Osier's "Practice." STATE BOARD EXAMINATION QUESTIONS. West Virginia State Board of Health. anatomy and embryology. i. Give the general characteristics of a vertebra. De- •cribe the atlas. 2. Describe the branches of the arch of the aorta. 3. Describe the course of the fibers in the optic com- missure. 4. Name and describe the ducts of the liver. 5. Give origin and insertion of sartorius muscle; give function. 6. Give blood supply of leg, mentioning venous compen- sation. 7. Give foramen of exit of the cranial nerves. 8. Name muscles of deglutition. 9. Tell what you know of fetal development from the time of contact of the spermatozoon with the ovum during the first six weeks of development. 10. Describe the palmar arches and mention their sur- gical significance. PHYSIOLOGY AND HISTOLOGY. r. Give origin and functions of the bile. 743 MEDICAL RECORD. v- 2. Give functions of the liver. 3. Give the amount of saliva secreted in twenty-four hours in the adult; also give functions of the saliva. 4. Give the amount of blood (in pounds) in the body and state the functions of the red corpuscles. 5. Give the amount of water and solids in the body of a person weighing 145 pounds. 6. Name the organs of digestion in the order in which they belong. 7. Locate, describe, and give functions of the spleen. 8. Locate, describe, and give functions of the pancreas. 9. Describe a Peyer's patch and tell where it is found. 10. Describe a lobule of the liver. CHEMISTRY AND MEDICAL JURISPRUDENCE. 1. What is an element, and how many are there? 2. Give chemical antidote for silver nitrate, mercury bichloride, tincture of iodine; what is formed? 3. Give Fehling's test for sugar. What is the chemical change as shown by reaction? 4. Would you treat burns with acids or alkalies, and why? 5. Define electrolysis. 6. Define oxidation; where does it occur in the body? 7. What are some of the certain signs of death? 8. Differentiate between dementia and hysteria. 9. Having visited a case, can the physician quit before its termination? 10. What are the legal requirements to practise medicine in West Virginia? MATERIA MEDICA AND THERAPEUTICS. 1. Mention the therapeutic uses of ergot. Give the physiological action. 2. Name four coal-tar products used to reduce tempera- ^ [ \> ture ; give dose of each. U? / ^ 3- Correct the following prescription: \J Atrophia sulphate, gr. i ss. Potassium iodid, 3ss. Infusa Digitalis, qs. ad. oz. ii. M-Sig. Teaspoonful in water four times daily. 4. Name four alkaloids of opium; give dose of each. ^ Name three indications for their use. What is the effect , & ^ of a full dose of opium on respiration? g 5. How many grains of cocaine are contained in an v ounce of a 20 per cent, solution? How many drops would ** you give an adult hypodermically? 6. Give dose of tincture of aconite root, tincture of digitalis, tincture of hyoscyamus (last edition of the Phar- macopoeia). What active principles are found in each? Give dose. 744 * r SJ MEDICAL RECORD. 7. State therapeutic uses of Pulvis jalapae compositus and give composition. 8. Mention eight drugs the use of any one of which may cause skin eruptions. 9. Give the composition and the chief use of lotio hydrargyri nigra. 10. What are the therapeutic uses of ammonium muriati- cum? BACTERIOLOGY AND HYGIENE. i. What is mixed infection? Illustrate. 2. Mention four of the most useful culture media. What should the reaction of a culture medium be? 3. Name the microorganism of erysipelas? What tissues does this microorganism chiefly effect? 4. Describe the method of staining sputum containing tubercle bacilli. 5. How do cells multiply? 6. Describe the modern system of ventilation. 7. What reasons can you give for not using personal clothing or toilet articles used by other people? 8. What diseases are known to be carried by animals and insects? 9. How would you manage a case of scarlet fever to prevent its spread, and what precautions would you take to avoid conveying it on your own clothing or person? 10. Give in detail the hygienic rules to be followed in every case of tuberculosis. SURGERY. 1. What is inflammation? How does it extend? How does it terminate? 2. What is an abscess? Define acute and chronic ab- scess. 3. What is a carbuncle? Give treatment. 4. Define septicemia. Define pyemia. 5. Make a diagnosis between apoplexy, uremic coma, in- toxication, and head injury. 6. What is lupus? Treatment? 7. Treatment of epistaxis? 8. Name and describe the different kinds of posture. 9. Describe and treat Colles's fracture. 10. What is orchitis? Treatment? OBSTETRICS AND GYNECOLOGY. i. In what way does the fetus receive its nourishment? Describe the placenta. 2. Cause, symptoms, and treatment of puerperal septi- cemia. 3. What are the dangers of a prolonged labor after the first stage is completed? 745 MEDICAL RECORD. 4. Menopause : What is it ? Symptoms and treatment ? Is it a physiological or pathological condition? 5. How long would you remain with patient after deliv- ery, and why? 6. Explain the action of the abdominal muscles in labor. 7. What changes take place in the female at puberty? 8. How would you proceed in case of puerperal eclamp- sia? Cause? 9. Describe operation for perineal laceration. When and why should it be done? 10. Give early symptoms and treatment of cancer of the cervix uteri. PRACTICE OF MEDICINE AND PEDIATRICS. 1. Give the cause and treatment of deficiency in excre- tion of urea. 2. Diagnose, treat, and give the cause of cholera in- fantum in an infant. 3. Etiology, symptoms, and treatment erf acute lobar pneumonia. 4. Give the causes, symptoms, and treatment of Bright' s disease. 5. Give the cause, symptoms, and treatment of hemiple- gia in a person over sixty years of age. 6. Tonsillitis: Differentiate from diphtheria; give symp- toms and treatment. 7. Intussusception : Define, diagnose, and treat. 8. Symptoms and treatment of empyema. 9. Give the etiology, pathology, duration, and treatment of typhoid fever, 10. Etiology, symptoms, and treatment of hysteria. SPECIAL PRACTICE. i. Give symptoms and diagnosis of chronic pleurisy with effusion. 2. Give symptoms and methods for early diagnosis of hip-joint disease. 3. Describe simple chronic laryngitis, giving diagnosis and treatment. 4. Diagnose and treat laryngeal diphtheria. 5. Give etiology, symptoms, diagnosis, and treatment of frontal sinus infection. 6. Diagnose and treat atrophic nasopharyngitis. 7. Describe the normal eye-ground as seen through the ophthalmoscope. 8. Describe eye conditions associated with chronic Bright's disease and diabetes mellitus. 9. Describe the normal knee-jerk. Give diagnostic sig- nificance of loss and exaggeration. 10. What is multiple neuritis? Give etiology and treat- ment. 746 MEDICAL RECORD ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. West Virginia State Board of Health. anatomy and embryology. i. The general characters of a vertebra are : Body or Centrum, and Neural arch. The latter consists of two pedicles, two laminae, and seven processes (four articular, two transverse, and 5he spinous). For atlas, see Cunning- ham's "Anatomy" (1909), page 79; or Gray's "Anatomy" (1908), page 50. 2. See Cunningham's "Anatomy" (1909), page 800; or Gray's "Anatomy" (1908), page 595. 3. See Cunningham's "Anatomy" (1909), page 676; or Gray's "Anatomy" (1908), page 1038. 4. See Cunningham's "Anatomy" (1909), page 11 18; or Gray's "Anatomy" (1908), page 1349. 5. Origin: Anterior superior spine of ilium and part of notch below. Insertion: Inner side of tibia near tubercle. Function: Flex leg on thigh, and thigh on pelvis; and rotate thigh outward. 6. See Cunningham's "Anatomy" (1909), pages 863 and 897; or Gray's "Anatomy" (1908), pages 707 and 756. 7. First through foramina in cribriform plate of eth- moid. Second, through optic foramen. Third, through sphenoidal fissure. Fourth, through sphenoidal fissure. Fifth, through sphenoidal fissure, foramen rotundum, and foramen ovale. Sixth, through sphenoidal fissure. Sev- enth, through stylomastoid foramen. Eighth, through in- ternal auditory meatus. Ninth, tenth, and eleventh, through jugular foramen. Twelfth, through anterior condyloid foramen. 8. Hyoglossi, styloglossi, palatoglossi, palatopharyngei, azygos uvulae, tensores palati, levatores palati, stylopharyn- gei, stylohyoids, geniohyoids, mylohyoids, thyrohyoids, digastrics, constrictors of the pharynx, and intrinsic mus- cles of tongue. 9. See Cunningham's "Anatomy" (1909), page 16; or Gray's "Anatomy" (1908), page 1559. 10. The superficial palmar arch is formed by the ulnar artery, and is completed by the ulnar artery anastomosing with a branch of the radial (superficial volar or princeps pollicis). It gives off the four digital branches. The sur- face marking is a line drawn transversely across the palm from a point where the web of the thumb joins the palm. The deep palmar arch is formed by the radial artery, and is completed by the radial artery anastomosing with a deep branch of the ulnar. Its branches are the palmar interos- 747 MEDICAL RECORD. seous, perforating, and palmar recurrent arteries. The surface marking is a line drawn transversely across the palm, one-half inch nearer the wrist than the superficial arch. Wounds in this region are dangerous on account of the difficulty in checking the hemorrhage, and also on ac- count of the important structures of the palm that may be damaged. In incision in the palm the line of these arteries should be avoided as far as possible. PHYSIOLOGY AND HISTOLOGY. i. The bile originates in the liver. The functions of the bile are: (i) To assist in the emulsification and saponifi- cation of fats; (2) to aid in the absorption of fats; (3) to stimulate the cells of the intestine to increased secretory activity, and so promote peristalsis, and at the same time tend to keep the feces moist; (4) to eliminate waste prod- ucts of metabolism, such as lecithin and cholesterin; (5) it has a slight action in converting starch into sugar; (6) it neutralizes the acid chyme from the stomach, and thus inhibits peptic digestion; (7) it has a very feeble antiseptic action. 2. The functions of the liver are: (1) The secretion of bile; (2) the formation of glycogen; (3) the formation of urea and uric acid; (4) the manufacture of heat, and (5) the conversion of poisonous and harmful into inert mate- rial. 3. Probably from two and one-half to three pounds of saliva are secreted daily by an adult. The functions of the saliva are: (1) To moisten the mouth; (2) to assist in the solution of the soluble portions of the food, and thus (3) to administer to the sense of taste; (4) to lubricate the bolus of food, and thus (5) to facilitate the acts of mastication and deglutition, and (6) to change starches into dextrin and sugar. 4. The blood is about one-thirteenth of the body weight. The function of the red corpuscles is to carry oxygen to the tissues. 5. Water being about two-thirds and solids one-third, there will be about 97 pounds water and 48 pounds solids. 6. Mouth (with tongue, teeth, and salivary glands), pharynx, esophagus, stomach, small intestine (duodenum, jejunum, ileum), large intestsine (cecum, ascending colon, transverse colon, descending colon, sigmoid flexure, and rectum), with liver and pancreas. 7. The function of the spleen: The following theories have been held: (1) It is a source of production of the white blood corpuscles; (2) it is a source of production of the red blood corpuscles during fetal life; (3) it is a place where the red blood corpuscles are destroyed; (4) uric 748 MEDICAL RECORD. acid is produced in the spleen; (5) an enzyme is produced in the spleen and is carried by the blood to the pancreas, where it converts the trypsinogen into trypsin. For loca- tion and description, see Cunningham's "Anatomy" (1909), page 1210; or Gray's "Anatomy" (1908), page 1361. 8. The functions of the pancreas are : (a) The secre- tion of the pancreatic juice, which (1) changes proteids into proteoses and peptones, and afterward decomposes them into leucin and tyrosin ; (2) converts starch into maltose; (3) emulsifies and saponifies fats, and (4) causes milk to curdle, (b) The manufacture of an internal secre- tion. For location and description, see Cunningham's "Anatomy" (1909), page 1124; or Gray's "Anatomy" (1908), page 1355. 9. See Cunningham's "Anatomy" (1909), page 1064; or Gray's "Anatomy" (1908), page 1304. id. A lobule of the liver is about 1-20 to 1-12 inch in diameter. It has a darkish red center and a lighter cir- cumference. The center is occupied by an intralobular vein which collects the blood from the capillaries of the lobule, and flows into the sublobular vein, which latter opens into the hepatic vein. Around the lobules are the interlobular veins; these are branches of the portal sys- tem; capillaries passing from the circumference to the center of the lobule connect the interlobular and intra- lobular veins. Between the network of capillaries in the lobule the heptaic cells are packed. CHEMISTRY AND MEDICAL JURISPRUDENCE. 1. An element is a substance which cannot, by any known means, be split up into two or more other kinds of sub- stance. There are 80 or 81 elements. 2. (1) For silver nitrate, sodium chloride; (2) for mer- cury bichloride, white of egg; (3) for tincture of iodine, no chemical antidote; but starch is given. There are formed (1) silver chloride, (2) mercury albuminate, (3) a blue color. 3. Fehling's test: Place in a test-tube a few c.c. of the liquid prepared as stated below, and boil ; no reddish tinge should be observable, even after five minutes' repose. Add the liquid under examination gradually, and boil after each addition. In the presence of sugar a yellow or red precipi- tate is formed. In the presence of traces of glucose, only a small amount of precipitate is produced, which adheres to the glass, and is best seen when the blue liquid is poured out. [The reagent must be kept in two solutions, which are to be mixed immediately before use. Solution I con- sists of 34.653 gms. of crystallized CuS0 4 , dissolved in water to 500 c.c, and solution II of 130 gms. of Rochelle 749 MEDICAL RECORD. salt dissolved to 500 c.c. in NaHO solution of sp. gr. 1.12. When required for use equal volumes of the two solutions are mixed, and the mixture diluted with four volumes of water.] The copper sulphate is reduced to copper oxide. 5. Electrolysis is the process of electrical conduction accompanied by the separation of the constituents of the electrolyte or the decomposition of a chemical compound by passing an electric current through it. 6. By oxidation is meant the act of union of oxygen with another element or compound. It occurs in all (or nearly all) the tissues of the body, chiefly in the lungs. 7. The complete and permanent cessation of respiration and circulation, rigor mortis, loss of body heat, pallor of the body, putrefaction. 8. Dementia is a condition of mental enfeeblement which gradually increases until absolute mental decay ensues. Hysteria is a morbid condition of the nervous system which may show every variety of nervous system due to deranged function of the cerebral and spinal centers, and associated with lowered will power and exaggerated emo- tional tendencies. 9. Yes; a physician can quit, provided he gives ample notice of his intention, so that the patient can obtain the services of another physician. 10. Graduation from a reputable medical college, recog- nized as such by the State Board of Health, and a certifi- cate giving license to practise, issued by the said State Board of Health. MATERIA MEDICA AND THERAPEUTICS. 1. Ergot. Therapeutic uses: To promote uterine con- tractions during third stage of labor; fibroids, menor- rhagia, postpartum hemorrhage. Some forms of amenor- rhea and dysmenorrhea, dysentery, arterial hemorrhage, congestive headaches, laxity of sphincters, of bladder or rectum, hemorrhoids, aneurysm, diabetes, urinary incon- tinence, direct paralysis of the sphincter vesicae, atonic sper- matorrhea. Physiological action: Ergot stimulates and causes contraction of involuntary muscle fibers, hence it is a vasoconstrictor, hemostatic, and oxytocic. It is also a cardiac sedative; it raises the blood pressure, it increases peristalsis, and is an emmenagogue. 2. Acetanilide, gr. iv; antipyrin, gr. iv; phenacetin, gr. vijss ; exalgin, gr. ij. 3. 5. Atropinae sulphatis, gr. 1/6. Potassii iodide, 3ss. Infusi digitalis q. s. ad 5ij. M. Sig : One teaspoonful in water four times a day. 4. Morphine, gr. 1/5; codeine, gr. 1/2; narcotine (hydro- 750 MEDICAL RECORD chlorid), gr. v; the other alkaloids are not used medicinally. Indications: To relieve pain; to produce sleep; to alloy irritation. Respiration is slowed. 5. Ninety-six grains. About one and a half minims; but I would not use a 20 per cent, solution. 6. TINCTURE OF DOSE ACTIVE PRINCIPLES DOSE Aconite. TT£x. Aconitine. gr. 1/400. Digitalis. TTgxv. Digitalin. gr. 1/150. Digitalein. gr. 1/100. Digitin. Digitonin. gr. 1/200 Digitoxin. gr. 1/150. Hyoscyamus. TT#xv. Hyoscyamine. gr. 1/128. Hyoscine. gr. 1/128. 7. As a hydragogue purge, in dropsy and cerebral con- gestion. It is composed of 35 parts of jalap and 65 parts of potassium bitartrate. 8. Belladonna, quinine, bromides, chloral, copeiba, cubebs, morphine, mercury. 9. It is made by adding one dram of calomel to a pint of lime water. It is chiefly used as a wash for syphilitic sores. 10. It stimulates the respiratory mucous membranes, and so is used in bronchitis and pneumonia; also in torpid and other liver conditions and ovarian neuralgia. BACTERIOLOGY AND HYGIENE. 1. A mixed infection is one in which more than one kind of microorganism is present — as tetanus bacillus, which thrives in the presence of saprophytic organisms which absorb the oxygen. 2. Gelatin, agar, blood-serum, bouillon. The reaction should be faintly alkaline or neutral. 3. Streptococcus erysipelatis: It chiefly affects the skin and connective tissues (lymph spaces and cellular tissues). 4. The sputum must be recent, free from particles of food or other foreign matter; select a cheesy-looking nodule and smear it on a slide, making the smear as thin as possible. Then cover it with some carbolfuchsin and let it steam over a small flame for about two minutes, care being taken that it does not boil. Wash it thoroughly in water and then decolorize by immersing it in a solution of any dilute mineral acid for about a minute. Then make a contrast stain with solution of Loeffler's methylene blue for about a minute ; wash it again and examine with oil immer- sion lens. The tubercle bacilli will appear as thin red rods, while all other bacteria will appear blue. 5. Cells multiply by : (1) Amitosis, and (2) karyokinesis. 751 MEDICAL RECORD. 6. "In the plenum system the air is drawn into a box, in which the revolving blades of a fan are located, and it is then driven into a central conduit and from there through appropriate shafts to the spaces for which it is intended. In the vacuum system the air is extracted from the vari- ous rooms through pipes leading to a central shaft, where it is drawn into the fan and discharged outwardly." 7. (i) It is a dirty habit; (2) it is also a dangerous habit, as disease- may be conveyed in this way. 8. Malaria, yellow fever, filariasis, bubonic plague, ty- phoid, cholera, leprosy, tuberculosis, smallpox, ringworm, sleeping-sickness, hook-worm disease, diphtheria, measles, scarlet fever, pneumonia, intestinal parasites, glanders, echinococcus, anthrax, rabies. 9. Complete isolation and quarantine, followed by rigid disinfection; special care must be taken during period of desquamation. On entering the room the physician should put on a sterilized gown over his clothes, and leave the gown behind him when he leaves ; he should also wash his hands with a disinfectant. 10. "The patient's quarters should be free from dust, and admit of spending many hours daily in the open air in all weathers, properly sheltered, and, if very ill, lying wrapped in a hammock or reclining chair. His bedroom should be well aired at night, draughts being avoided. The room should be uncarpeted and free from hangings. It should be often cleaned and periodically disinfected. All sputum should be collected in paper spit-cups, which should be burned daily. Smoking should be forbidden. Harm is done by any exercise which results in fatigue, and while fever exists it should not be attempted at all. Patients should be taught the necessity of practising lung gymnastics and breathing only through the nose, which should be kept clear and free from occlusion by secretions, or an hyper- trophied catarrhal mucosa. . . . The clothing should be woolen, but not too heavy, or sweating is increased ; and a flannel nightgown and loosely knit leggings should be worn at night in cool weather. The skin should be cleansed by daily sponge-baths of lukewarm alcohol and water." SURGERY. I. Inflammation is the succession of changes which oc- cur in a part as the result of some kind of injury, pro- vided that this injury is not sufficient to immediately de- stroy the vitality of the part. It extends by the blood vessels, lymphatics, and continuity of tissue. It terminates in return of the tissues to health (by resolution or organ- ization or new growth), or by death of tissue (by suppu- ration, ulceration, or gangrene). 752 MEDICAL RECORD. 2. An abscess is a circumscribed collection of a pus in a cavity of new formation. Acute abscesses are marked by inflammatory symptoms, pain, and heat, and by rapid de- velopment; chronic abscesses, by the absence of pain and heat, and by their sluggish course. 3. A carbuncle is a localized inflammation of the sub- cutaneous tissue, with fibrinous exudation and multiple necrotic foci. Treatment: Tonics, stimulants, good diet, free, crucial incisions with curetting of the sloughs, and swabbing with pure carbolic acid. 4. Septicemia is a condition due to microorganisms mul- tiplying in the blood, and is characterized by high tempera- ture, but not relieved by getting rid of the original source of infection. Pyemia is due to particles of blood clot car- rying microorganisms to parts distant from the original source and there setting up metastatic abscesses. 753 O CD §•8 CO Oh (J rG a o CO cJ s u o . 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Lupus vulgaris is a tuberculous infection of the skin; it is generally found upon the face, particularly the nose and cheeks. It begins as pinkish nodule which is painless, and spreads to other nodules, and generally ends in ulcera- tion, with destruction of mucous membrane or cartilage. Treatment: In the early stages the small nodule may be excised. If not seen till later, curettage with a sharp spoon, followed by cauterization with pure carbolic acid, has been recommended. This can be repeated at intervals of threte or four weeks, if necessary. Finsen light and tuberculin have also been used. 7. To arrest epistaxis: (1) Try to cauterize the bleeding point; (2) plug the nasal cavity with gauze soaked in adrenalin; (3) inject into the nares a solution of peroxide of hydrogen; (4) plugging the nares, anteriorly and poste- riorly; (5) an inflating plug may be used. 8. Postures. Dorsal, one in which the patient lies on the back; knee-chest, or genupectoral, one in which the patient rests upon the knees and chest, the arms being crossed above the head; knee-elbow, or genucubital, one in which the patient lies upon the knees and elbows, the head resting upon the hands ; lithotomy, one in which the patient lies on the back with the legs flexed on the thighs, and the thighs flexed on the abdomen and abducted; Sim's, one in which the patient lies on the left side, with the right knee and thigh drawn up and the left arm placed along the back; the chest is inclined forward so that the patient rests upon it; EdebohVs, one in which the patient lies on the back, with the legs flexed on the thighs and the thighs on the abdomen, the hips being elevated and the thigh strongly abducted ; Trendelenburg's, one in which the patient lies on the back, on a plane inclined about 45 , the feet and legs hanging over the end of the table. 9. Colles' fracture is a fracture of the lower end of the radius; it is generally transverse, and is usually within an inch or an inch and a half of the articular surface. There is a characteristic deformity caused by the lower fragment, and the carpus forming a prominence on the dorsal surface ; at the same time there is a projection on the palmar sur- face just above the wrist, caused by the upper fragment. The hand is abducted and pronated, and the styloid process of the ulna becomes very prominent. It is generally caused by a fall on the outstretched palm. For treatment, see Rose and Carless' "Surgery" (1908), page 522; or Da Costa's "Surgery" (1908), page 507. 10. Orchitis is inflammation of the testicle. Treatment: Rest in bed ; elevation of the parts ; hot or cold applications ; nain is to be relieved by opiates or leeches ; lead water and laudanum should be applied ; salines or cathartics are to be 755 MEDICAL RECORD. administered. Sometimes strapping the testicle is of ser- vice ; so, too, is the application of ichthyol and lanolin. OBSTETRICS AND GYNECOLOGY. i. Nutrition of fetus: "(i) At first the ovum absorbs nutriment simply through the vitelline membrane, while passing through the Fallopian tube. The nutrient material is supplied by the secretion of the tube itself, or may con- sist in part of seminal fluid introduced from without. (2) The vitellus is absorbed by the entoderm lining the umbil- ical vesicle and alimentary canal, and later it is absorbed and conveyed into the body of the embryo by the blood- vessels of the area vasculosa. (3) When the contents of the umbilical vesicle are exhausted the chorial villi appear and take up nourishment from the uterine decidua, with which they are in contact. (4) With the disappearance of villi in the chorion leve, the villi of the decidual serotina develop into the placenta, where they take up nutriment from the maternal blood with which they are surrounded." At full term the placenta is a soft, spongy mass, roughly saucer-shaped, from six to nine inches in diameter, about three-quarters of an inch in thickness at the central point, and weighs about one pound. 2. See Williams' "Obstetrics" (1909), page 852; or Hirst's "Obstetrics" (1909), page 764. 3. Asphyxiation of fetus; inspiration-pneumonia of fe- tus ; death or exhaustion of mother ; pressure necrosis for- mation of fistulse; sepsis; and post-partum hemorrhage. 4. Menopause is the period when menstruation ceases; it usually occurs between the fortieth and fiftieth years; it is attended by disturbances of digestion, flashes of heat, ner- vous troubles; treatment is symptomatic, dietetic, and hygienic. It is a physiological condition normally, but may become pathological. 5. At least one hour; longer if necessary; for fear of post-partum hemorrhage ; the uterine contraction should be good and the pulse below 100 before the physician leaves. 6. See Williams' "Obstetrics" (1909), page 286; or Hirst's "Obstetrics" (1909), page 333. 7. Development of the reproductive organs, enlargement of the breast, hair on pubis and axilla; the form becomes rounded, the hips widen, menstruation occurs ; there are certain mental and emotional changes, and^ "the develop- ment of those womanly beauties physiologically designed to attract the male." 8. Puerperal eclampsia. Preventive treatment: (1) The amount of nitrogenous food should be diminished to a minimum; (2) the production and absorption of poisonous materials in the intestines and body tissues should be lim- _ 756 MEDICAL RECORD. ited and their elimination should be aided by improving the action of the bowels, the kidneys, the liver, the skin, and the lungs; (3) the source of the fetal metabolic products and the peripheral irritation in the uterus should, if neces- sary, be removed by evacuating that organ. Curative treat- ment: (1) Controlling the convulsions (by chloroform, veratrum, or chloral) ; (2) elimination of the poison or poisons which are presumed to cause the convulsions; (3) emptying the uterus under deep anesthesia, by some method that is rapid and that will cause as little injury to the woman as possible. The causes may be : Uremia, albumin- uria, imperfect elimination of carbon dioxide by the lungs, medicinal poisons, septic infection; predisposing causes are renal disease and imperfect elimination by the skin, bowels, and kidneys. 9. See Williams' "Obstetrics" (1909), page 325; or Hirst's "Obstetrics" (1909), pages 609 and 868. 10. Cancer of the cervix. Early symptoms: Pain, hemorrhage, offensive discharge, wasting; the cervix is enlarged and breaks down. Treatment : Removal of the uterus. PRACTICE OF MEDICINE AND PEDIATRICS. 1. Causes: Carcinoma, cirrhosis of liver, acute febrile jaundice, nephritis, Addison's disease, lead poisoning. Treatment: Purgatives (elatorium, calomel, compound jalap powder), hot bath, amylnitrite, liquid diet. And see answer to Obstetrics, 8. 2. See French's "Practice" (1907), page 782; or Osier's "Practice" (1909), page 507. 3. See French's "Practice" (1907), page 151; or Osier's "Practice" (1909), page 165. 4. See French's "Practice" (1907), page 892; or Osier's "Practice" (1909), page 686. 5. See French's "Practice" (1907), page 1071 ; or Osier's "Practice" (1909), page 966. 6. In diphtheria the onset is more gradual ; the tempera- ture rises to about 101 to 103 F. ; the tonsils are not much enlarged ; there is an exudate of a thick, grayish membrane which is very adherent, is removed only with difficulty, and leaves a bleeding surface; this membrane soon reforms and may be found on the fauces and pharynx as well as on the tonsils ; in the exudate the Klebs-Loef- fler bacilli may be found. In follicular tonsillitis the onset is more sudden; the temperature may be a little higher than that of diphtheria; there is no membrane, but the tonsils are read and swollen, and in the crypts are seen white, cheesy spots or plugs, which consist of broken- down epithelium, and are easily brushed away; Klebs- 757 MEDICAL RECORD. Loeffler bacilli are never found. See French's "Practice' (1907), page 719; or Osier's "Practice" (1909), page 445. 7. STRANGULATION Subjective Symptoms. 1. Generally occurs after age of 20. 2. Pain localized, rapid collapse. 3. Pain intense, paroxysmal in character. 4. C o n s t i p ation complete. Objective Symptoms. Temper ature often subnor- mal. Pulse very weak. S t e r coraceous vomiting comes on ear- Location in small intestine. INTUSSUSCEPTION. Subjective Symptoms. 1. Most frequent in childhood. 2. Constant tenes- mus. 3. Pain develops suddenly and is continuous. 4. Frequent diar- rhea, passage of bloody mu- cous. Objective Symptoms. 1. Temper ature normal or sub- normal. 2. Same as in strangulation. 3. Same as in strangulation. 4. Localization in small intes- tine; bowel frequent ly protrudes a t rectum. TWISTS (volvulus) Subjective Symptoms. 1. Most frequent after age of 30. 2. Pain diffuse. 3. Pain paroxys- mal ; recurs less often than in strangula- tion. 4. Constipation complete. Objective Symptoms. Temperature slightly e 1 e - vated. Same as in strangulation. S am e as in strangulation. 4. Location, small intestine ; ab- domen often protrudes, in certain areas, giving dull- ness on per- cussion. — See French's "Practice" (1907), page 799; or Osier's "Practice" (1909), page 519. 8. Empyema. Symptoms: High and irregular fever, sweats, chill, diminished breath sounds and vocal femitus, impaired mobility of chest, dullness on affected side, heart displaced to opposite side, leucocytosis. Absolute diagnosis is made by aspiration, showing the fluid to be pus. Treat- ment: Aspiration, drainage, irrigation, resection of ribs 758 MEDICAL RECORD. (Estlander's operation), or resection of chest wall (Schede's operation). 9. See French's "Practice" (1907), page 65; or Osier's "Practice" (1909), page 57. 10. See French's "Practice" (1907), page 1140; or Osier's "Practice" (1909), page 1076. SPECIAL PRACTICE. 1. See French's "Practice" (1907), page 701; or Osier's "Practice" (1909), page 655. 2. The early symptoms of hip-joint disease are: Night cries (in a child) ; lameness in the morning; a slight limp; tendency to become tired on slight exertion; wasting; spasm* pain; swelling; and deformity (either real or ap- parent). 3. Simple chronic laryngitis may follow an acute at- tack, and be due to the same causes. The symptoms are tickling in the throat, hoarseness, persistent cough, and thick, tenacious, mucoid expectoration. Physical examina- tion reveals congestion and granulations on the mucous membrane. The general treatment is largely dietetic, stimulant, and hygienic. The local treatment consists in removing erosions or enlarged follicles under cocaine by means of silver nitrate or the galvanocautery, and the use of stimulating inhalations and applications. Silver nitrate (gr. 10-20 to 3 1 )* glycerite of tannin, or boro- glycerid (50 per cent.) may be used as application. Alka- line sprays and nasal douches may be employed. Guaiac may be administered in lozenge form. 4. See French's "Practice" (1907), page 188; or Osier's "Practice" (1909), page 202. 5. Frontal sinus infection. Etiology: Extension from ethmoid cells, or obstruction of the nasofrontal duct; or hypertrophic inflammation of the mucosa or growths within the nose. Symptoms and diagnosis: Throbbing pain in frontal cells, discharge of offensive mucopurulent pus from one or both sides; transillumination will be diminished on the affected side. Treatment consists in laying open the cavity, through an incision along the inner part of the eyebrow, and trephining. The wall is curetted^ the in- fundibulum enlarged, and a drainage tube left in it for two or three days. The cavity is then washed out daily through the nose till all discharge has ceased. 6. Atrophic nasopharyngitis. Symptoms: Characteris- tic burning, itching sensation, and an extremely dry feeling in the throat. There is usually a dry hacking cough, very little expectoration except what accumulates in the post- nasal space, and is removed by hawking it up. The secre- tions of the glands are changed in quality; they become thick and tend to stick to the pharynx, forming dry crusts 759 MEDICAL RECORD. and scabs which are very hard to remove. The membrane may look dry, parched, and glazed, with here and there a nodular condition. If the secretions are examined, a great variety of bacteria may be found. Treatment: Remove any constitutional causes as quickly as possible. Get the general health into good condition, and keep the parts thoroughly clean with a gargle or spray. If there are any congested spots, correct these by applications of nitrate of silver^ Give cathartics if necessary, and attend to the digestive tract and to the hygienic surroundings. 7. "In carrying out a complete examination of the fundus the two landmarks which should be first found are the optic nerve and the macula (yellow spot). The former appears as an oval pinkish-white disk. A pit with sloping sides is in the center (physiological excavation), with the mottled appearance of the lamina cribrosa at its bottom. A white ring of varying breadth (scleral ring) surrounds the disk, and outside of this more or less pigment (choroi- dal ring). From the nerve comes the central artery of the retina as a single trunk, or already divided, and it then divides and subdivides on the retina. The veins follow in general the same course as the arteries, The color, amount of blood supply, sharpness of outline, and swelling of the disk should not escape notice. The presence of an excavation with sharp sides, over which the vessels seem to fall (cupped disk), may denote glaucoma. The other landmark — the macula — which is very difficult to see when the pupil is small, is an area of deeper color than the sur- rounding fundus, and shows a pit in its center with a bright reflex (fovea centralis). The retinal vessels should be followed from the nerve over the fundus and changes in them noted. The general appearance of the fundus is variable with the amount of pigment, depending on the complexion of the individual." 8. In chronic Bright 's disease there may be albuminuric retinitis, with serious swelling of the disk and surrounding retina, hemorrhagic extravasations, dilatation of capillaries and veins, with fatty or hyaline degeneration of the ves- sel walls. In diabetes mellitus the vessels of the retina may be dilated, the retina may atrophy, the fundus is light yellow in color; amblyopia, presbyopia, and loss of accom- modation may occur. 9. When the thigh is supported and the leg flexed at the knee, a tap on the tendon just below the patella causes the leg to be suddenly extended. It is lost in locomotor ataxia, transverse myelitis, poliomyelitis, peripheral neuritis, spinal meningitis, epilepsy, and chorea. It is exaggerated in apoplexy, sclerosis, paraplegia, unilateral lesions of spinal cord, tetanus, cerebellar ataxia. 10. Multiple neuritis is a neuritis (inflammation of 760 MEDICAL RECORD. bundles of nerve fibers) in which several nerves are in- volved. Etiology: Poisons of infectious diseases, or or- ganic or mineral poisons, cachectic conditions, exposure to cold, overexertion. Treatment: Rest in bed, morphine or hot applications, strychnine, arsenic, and heat (and re- move) the cause. STATE BOARD EXAMINATION QUESTIONS. Wisconsin Board of Medical Examiners. ANATOMY. 1. Name the bones of the head (including the facial). 2. About how many bones are there in the human body? 3. Name each cranial nerve and give its foramen of exit. 4. Describe the spinal nerves. 5. Describe the eyeball. 6. What are the lymphatics? 7. Describe the aorta. 8. Describe the ossicles of the tympanum. PEDIATRICS. 1. Give symptoms and treatment of intussusception. 2. Give the symptomatology and treatment of hereditary syphilis. 3. Give etiology and treatment of enuresis. 4. Give synonyms, symptoms, and treatment of mem- branous laryngitis. PATHOLOGY, HISTOLOGY, BACTERIOLOGY. i. Define degeneration. Give causes of fatty and amyloid degeneration. 2. Name types of infarcts. Give description of one type. 3. Differentiate transudate and exudate. 4. Give classification of inflammations, and describe one form. 5. Give pathology of atrophic cirrhosis of liver. 6. Give pathology of parenchymatous nephritis in detail. 7. (a) Name the tumors of connective tissue origin, (b) What determines the malignancy of tumors? 8. What are the causes of arteriosclerosis? Give patho- logical histology. 9. Name the diseases due to bacteria. How are these diseases communicated? 10. (a) Give method of staining the tubercle bacillus. (b) Give method of making a Widal reaction. 11. Differentiate the mucosa of the gastrointestinal tract from mouth to anus. 12. Describe blood-supply of liver in detail. 761 MEDICAL RECORD. PRINCIPLES AND PRACTICE. i. Name four organic heart lesions and give the physical signs in two of them. 2. Describe a typical case of typhoid fever. 3. Give the diagnosis of acute lobar pneumonia. Give the treatment of first stage. 4. Give diagnosis of entrocolitis. 5. Give diagnosis and treatment of round ulcer of the stomach. 6. What is amyloid liver? Give diagnosis. 7. Give etiology and diagnosis of arteriosclerosis. MATERIA MEDICA AND THERAPEUTICS. i. Name six antiseptics in the order of their power to destroy bacteria. 2. What are the physiological actions and therapeutical uses of arsenic? 3. What anthelmintics are used against the different in- testinal parasites respectively? 4. Name five preparations of mercury, with the doses of each. 5. Give the physiological actions of strychnine in poison- ous doses, and tell why it destroys life. 6. How would you treat a case of strychnine poisoning? 7. Name six preparations of iron, with the doses of each. OBSTETRICS. 1. Give the physiology of pregnancy. 2. Give hygiene of pregnancy. 3. Explain the mechanism of labor. 4. Give etiology and treatment of hyperemesis gravi- darum. 5. Explain the reasons for the rarity of conception in a prolapsed uterus. If pregnancy does occur in complete prolapse, what is the result? 6. Give diagnosis and treatment of hydatid mole during pregnancy. 7. Give etiology and symptomatology of puerperal eclampsia. 8. Name the causes and give treatment for postpartum hemorrhage. GYNECOLOGY. 1. Give the pathology of menstruation. 2. State cause and treatment of sterility. 3. Give symptoms, course, and diagnosis of metritis. 4. What are the indications for curettage of the uterine cavity. Describe method of procedure and dangers to be avoided. 762 MEDICAL RECORD. NEUROLOGY, DIETETICS, MEDICAL- JURISPRUDENCE, i. (a) What is the structural and functional unit of the nervous system? (b) Give brief description of same, (c) What area of the cord is affected in acute anterior polio- myelitis? 2. (a) Describe briefly the spinal cord and name from within out its three protective membranes, (b) At what level of the spine does the cord terminate? (c) In locomo- tor ataxia, where is the primary degeneration? 3. (a) Give names of the seventh, eighth, tenth, and twelfth pairs of cranial nerves, (b) Give function and distribution of any two mentioned, (c) Locate the Gas- serian ganglion. 4. (a) Give origin, course, and distribution of the great sciatic nerve, (b) What are the names of the two large branches into which it divides? (c) At about what point does the division take place? 5. (a) Name the nerves which, under normal circum- stances, control the action of the heart, (b) Explain how these nerves differ in their function. 6. Differentiate between criminal and justifiable abortion. 7. What is the difference between expert testimony and other testimony. Give four positive signs of death. 8. Mention the steps necessary and on what basis may a patient be committed to an insane asylum. 9. Name three articles of diet which are tissue formers. Name four articles of diet which are work and heat pro- ducers. 10. Give dietetic treatment for typhoid fever from first day of positive diagnosis. 11. About how much water should be consumed during twenty-four hours by a person weighing 150 pounds, aside from what he obtains from his food. Name four func- tions of water in the system. 12. Name the chief source from which the body obtains its fat. Give dietetic treatment for apoplexy, and give your reasons for same. PHYSIOLOGY, OPHTHALMOLOGY, AND LARYNGOLOGY. i. Give origin, distribution, and function of the pneumo- gastric nerve. 2. What is the effect of alcohol on brain tissue, hepatic tissue, and stomach? 3. Write a detailed description of the function of the seventh cranial nerve. 4. Discuss briefly the physiology of the liver. 5. What would be the results of eating in excess of albuminous, oleaginous, and farinaceous foods? 763 MEDICAL RECORD. 6. (a) Discuss inflammation, (b) What are the functions of the skin? 7. Give function and composition of saliva, gastric juice, and bile. 8. Describe manner of using the ophthalmoscope, and name some of the diseases that can be diagnosed by its use. 9. Give diagnosis and treatment of iritis and keratitis. 10. Define hordeolum, chalazion, ptosis, astigmatism, myopia, glaucoma, and refraction. 11. Differentiate diphtheria and follicular tonsillitis. 12. Differentiate chronic laryngitis and tuberculous laryngitis, and give treatment of each. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. Wisconsin Board of Medical Examiners, anatomy. 1. Occipital, 2 parietal, 2 temporal, frontal, ethmoid, sphenoid, 2 lacrymal, 2 malar, 2 nasal, 2 palate, 2 superior maxillary, 2 inferior turbinate, vomer, and inferior maxil- lary. 2. There are 206 named bones in the human body. 3. First, or olfactory, through foramina in cribriform plate of ethmoid. Second, or optic, through optic fora- men. Third, or motor oculi, through sphenoidal fissure. Fourth, or trochlear, through sphenoidal fissure. Fifth, or trigeminus, through sphenoidal fissure, foramen rotundum, and foramen ovale. Sixth, or abducens, through sphenoidal fissure. Seventh, or facial, through stylomastoid foramen. Eighth, or auditory, through internal auditory meatus. Ninth, or glossopharyngeal; tenth, or pneumogastric, and eleventh, or spinal accessory, through jugular foramen. Twelfth, or hypoglossal, through anterior condyloid foramen. 4. See Cunningham's Anatomy (1909), page 607; or Gray's Anatomy (1908), page 982. 5. See Cunningham's Anatomy (1909), page 723; or Gray's Anatomy (1908), page 11 13. 6. See Cunningham's Anatomy (1909), page 905; or Gray's Anatomy (1908), page 772. 7. See Cunningham's Anatomy (1909), page 797; or Gray's Anatomy (1908), pages 589, 593, 667 and 670. 8. See Cunningham's Anatomy (1909), page 754; or Gray's Anatomy (1908), page 1168. PEDIATRICS. 1. See French's Practice (1907), page 799; or Osier's Practice (1909), pages 519 and 524. 764 MEDICAL RECORD. 2. See French's Practice (1907), pages 424 and 429; or Osier's Practice (1909), pages 269 and 289. 3. Enuresis. Etiology: Irritation of bladder, phimosis, adherent prepuce, caruncle, threadworms in rectum, fissure, overloaded rectum, stone in bladder, very acid or alkaline urine, paralysis, hip-joint disease, drinking too much fluid before bed time. Treatment: Remove cause, if possible; light diet, restricted fluids before bed time, light bed clothes, regular habits of urination and defecation, raising the foot of the bed, cold sponging, electricity; belladonna, bromides, ergot, cantharides and potassium nitrate have all been used for the relief of this condition. 4. Membranous laryngitis is practically diphtheria. See French's Practice (1907), page 184; or Osier's Practice (1909), page 200. Synonyms: Croup, membranous croup, angina membranacea, cynanche maligna, putrid sore throat, angina maligna, etc. PATHOLOGY, HISTOLOGY, BACTERIOLOGY. 1. Degeneration is a pathological process in which abnor- mal substances are formed within living cells, or the entire cells are transformed into abnormal material. Causes of fatty degeneration: Excess of oxidizable material, heredity, diminished oxidation, high temperature, atrophy of the liver, poisons, anemia, cachexia, diabetes. Causes of amy- loid degeneration: Suppuration, ulceration, tuberculosis, syphilis, gastroenteritis. 2. Types: Red or hemorrhagic, and white or anemic. Red infarcts are blackish red in color; have a slightly raised base; are surrounded by a hyperemic zone (if re- cent) ; are commonly found in lungs, spleen, and kidneys ; the area of infarction is cone shaped, with the base at the surface of the organ, the apex pointing towards the center, and corresponding to the point of entrance and exit of the artery and vein. The blood-vessels are overfilled, due to either a backflow of blood from the veins, or to a free capillary anastomosis. 3. When the accumulation of fluid is due to circulatory disturbances it is called a transudate ; when it is due to inflammation it is called exudate. Transudates do not, as a rule, coagulate, but may become slightly turbid on heat- ing; and their specific gravity is usually below 1015. Exu- dates are rich in albumin, and so coagulate on heating; they are also rich in fibrin, and so may coagulate sponta- neously ; their specific gravity is usually above 1018. 4. See Rose and Carless' "Surgery" (1908), page 40; or Da Costa's "Surgery" (1908), page 81. 5. In atrophic cirrhosis: The liver is shrunken and in- durated, rough, and of a pale or yellow color; a growth of new. connective tissue is disposed in broad bands which 765 MEDICAL RECORD. run in various directions, and by their contraction divide the liver into numerous irregular lobes. Many acini may be affected at one time. The capsule may be thickened, or adherent to the diaphragm. Jaundice is slight, and comes on late; ascites is pronounced and may occur early. 6. In chronic parenchymatous nephritis, "both degenera- tive and proliferative changes are seen. The tubular epithelium is always more or less affected, showing signs of cloudy swellirig, fatty degeneration, desquamation, and disintegration, most marked in the convoluted tubules, but also present in the loops and collecting tubules. The dis- tribution of these changes is usually patchy, giving rise to mottling of the cortex. The lumen of the tubes may be dilated, and contain granular and fatty matters, and hyaline casts, the latter formed by coagulation of exuda- tion in the tubules. The glomeruli may occasionally appear normal, but there is almost always some swelling and hya- line degeneration, together with some proliferation and desquamation, of the epithelium, so that they become highly cellular. Occasionally the glomerular changes may be more marked than the tubular; fatty degeneration of the glomerular and capsular epithelium may be prominent, or there may be swelling, proliferation, and desquamation of the epithelium, or both these changes may be combined. The glomerular vessels may be compressed, their endo- thelium degenerate, and they may be obstructed by leuco- cytes or by hyaline thrombi, and finally obliterated. In- terstitial changes, though present, are not conspicuous, and consist of edema, and scattered foci of round-celled in- filtration about the glomeruli and veins. Sometimes hemor- rhages are evident in some of the glomeruli and the cor- responding tubules. Lardaceous infiltration frequently ac- companies parenchymatous nephritis." 7. (a) Lipoma, myoma, neuroma, chondroma, fibroma, osteoma, odontoma, myxoma, glioma, angioma, sarcoma. (b) Malignant tumors are not encapsulated, tend to in- filtrate the surrounding tissues, give rise to metastatic growths, have a tendency to recur after removal, give a cachexia, have a fatal tendency. 8. The causes of arteriosclerosis are: Increased blood- pressure, old age, overeating, alcohol, lead poisoning, gout, syphilis, high pressure of modern life, renal disease. In arteriosclerosis it is mainly the inner coat which is affected; this becomes thickened by layers of fibrous tissue owing to the proliferation of the subendothelial connective tissue cells. This thickening is not uniform. The elastic layer becomes granular, and it may be partially destroyed. Where high arterial tension exists the media is affected, and the muscle fibers become hypertrophied ; sometimes degeneration occurs here. The vessels increase in length 766 MEDICAL RECORD and thickness, becoming tortuous; they also feel resistant and cord-like. 9. Diseases due to bacteria: Typhoid, dysentery, syphilis, relapsing fever, Malta fever, influenza, bubonic plague, anthrax, cholera, diphtheria, tetanus, glanders, leprosy, tuberculosis, pneumonia, gonorrhea, cerebrospinal menin- gitis; and probably: mumps, rabies, yellow fever, whooping cough, scarlet fever, smallpox, typhus, vaccine, chicken- pox, rubella, dengue, rheumatism, beri-beri, glandular fever. Communication may he by: Air, food, drink, contact, fomites, insects. 10. (a) To demonstrate the existence of tubercle bacilli in the sputum : The sputum must be recent, free from par- ticles of food or other foreign matter; select a cheesy- looking nodule and smear it on a slide, making the smear as thin as possible. Then cover it with some carbolfuch- sin, and let it steam over a small flame for about two minutes, care being taken that it does not boil. Wash it thoroughly in water and then decolorize by immersing it in a solution of any dilute mineral acid for about a minute. Then make a contrast stain with solution of Loeffler's methylene blue for about a minute ; wash it again and examine with oil immersion lens. The tubercle bacilli will appear as thin red rods, while all other bacteria will appear blue. (b) The Widal reaction: "Three drops of blood are taken from the well-washed aseptic finger tip or lobe of the ear, and each lies by itself on a sterile slide, passed through a flame and cooled just before use; this slide may be wrapped in cotton and transported for examination at the laboratory. Here one drop is mixed with a large drop of sterile water, to redissolve it. A drop from the summit of this is then mixed with six drops of fresh broth culture of the bacillus (not over twenty-four hours old) on a sterile slide. From this a small drop of mingled culture and blood is placed in the middle of a sterile cover-glass, and this is inverted over a sterile hollow-ground slide and examined. ... A positive reaction is obtained when all the bacilli present gather in one or two masses or clumps, and cease their rapid movement inside of twenty minutes/' (From Thayer's Pathology.) 11. The lips, mouth, tongue, pharynx, and esophagus are all lined with stratified squamous epithelium; the esophagus, further, has mucous glands; the stomach is lined with columnar cells, has gastric glands, with shallow crypts, and acid and peptic cells ; the small intestine is lined with simple columnar cells, has also goblet cells, Brunner's glands, crypts of Lieberkuhn, villi and valvulae conniverites ; the large intestine is li-ed with simple colum- 767 MEDICAL RECORD nar epithelium, has goblet cells, crypts, but no villi or valvulse connivents; the anus is lined with stratified squamous epithelial cells. 12. See Cunningham's "Anatomy" (1909), page 1120; or Gray's " Anatomy" (1908), page 1346. PRINCIPLES AND PRACTICE. 1. Mitral regurgitation, mitral obstruction, aortic regur- gitation, aortic obstruction. See French's "Practice" (1907), page 576; or Osier's "Practice" (1909), page 796. 2. See French's "Practice" (1907), page 74; or Osier's "Practice" (1909), page 70. 3. See French's "Practice" (1907), pages 156 and 174; or Osier's "Practice" (1909), pages 172 and 189. 4. See French's "Practice" (1907), page 785; or Osier's "Practice" (1909) page 508. 5. See French's "Practice" (1907), pages 748 and 751; or Osier's "Practice" (1909), pages 473 and 477. 6. See French's "Practice" (1907), page 838; or Osier's "Practice" (1909), page 571. 7. See French's "Practice" (1907), pages 623, 626, and 628; or Osier's "Practice" (1909), pages 848 and 851. MATERIA MEDICA AND THERAPEUTICS. 1. Formalin, hydrogen dioxide, mercury bichloride, sil- ver nitrate, creolin, and chromic acid. 2. Arsenic. Physiological action: Escharotic; irritant, tonic ; increases cardiac action, respiratory power, intestinal secretions, and peristalsis; produces edema, itching, diar- rhea, epigastric pain, irritable and feeble heart. Thera- peutic uses: In stomach disorders, bronchial and pulmon- ary affections, diabetes, diarrhea, anemia, and chlorosis, chorea, malaria, and chronic skin diseases. 3. Anthelmintics are given by Potter as follows: For threadworm (Oxyuris vermicular is) — alum, ferrous sul- phate, lime-water, quassia, sodium chloride, tannin, all by enema. For roundworm (Ascaris lumbricoides) — santo- nin, spigelia, chenopodium, azedarach, internally, with senna or calomel. For tapeworms (Teniae, etc.) — aspidium (filix mas), kamala, cusso, granatum (pelletierine), pepo, turpentine, chloroform. For hookworm (Uncinaria, Anky- lostomum) — thymol, aspidium. 4. (1) Hydrargyri chloridum corrosivum, gr. 1/20; (2) hydiargyri iodidum rubrum, gr. 1/20: massa hydrargyri, gr. iv; (4) hydrargyri chloridum mite, gr. ij ; (5) hydrar- gyrum cum creta, gr. iv. 5. The symptoms of poisoning by strychnine are "a sense of suffocation, thirst, tetanic spasms, usually opisthotonos, sometimes emprosthotonos, occasionally vomiting, contrac- tion of the pupils during the spasms, and death, either by 768 MEDICAL RECORD asphyxia during a paroxysm, or by exhaustion during a remission. The symptoms appear in from a few minutes to an hour after taking the poison, usually in less than twenty minutes ; and death in from five minutes to six hours, usually within two hours." 6. Treatment of strychnine poisoning: The convulsions are to be arrested or mitigated by bringing the patient under the influence of chloral or chloroform as rapidly as possible; the stomach is to be washed out, and the patient is to be kept as quiet as possible. 7. (1) Tincture of ferric cnloride, Tl£viij ; (2) Basham's mixture, 3iv; (3) reduced iron, gr. j; (4) syrup of ferrous iodide, n^xv; (5) tartarated iron, gr. iv; (6) dried sulphate of iron, gr. ij. OBSTETRICS. 1. See Williams' "Obstetrics" (1909), page 164; or Hirst's "Obstetrics" (1909), page 180. 2. See Williams' "Obstetrics" (1909), page 199; or Hirst's "Obstetrics" (1909), page 188. 3. See Williams' "Obstetrics" (1909), page 235; or Hirst's "Obstetrics" (1909), page 3$&. 4. See Williams' "Obstetrics" (1909), page 509; or Hirst's "Obstetrics" (1909), page 238. 5. See Williams' "Obstetrics" (1909), page 672; or Hirst's "Obstetrics" (1909), page 221. 6. Diagnosis of hydatids: The pregnancy begins as in normal cases, but in about the third month the uterus be- comes suddenly and rapidly enlarged; irregular uterine hemorrhages occur; and there is a discharge of fluid con- taining the vesicular growths ; labor occurs, and the mass of cysts is expelled. Treatment: Empty the uterus as soon as possible, but beware of rupturing the uterine wall ; and secure uterine contraction. 7. Puerperal eclampsia. Etiology: Uremia, albumi- nuria, imperfect elimination of carbon dioxide by the lungs, medicinal poisons, septic infection; predisposing causes are renal disease and imperfect elimination by the skin, bowels, and kidneys. Symptoms: Headache, nausea, and vomiting, epigastric pain, vertigo, ringing in the ears, flashes of light or darkness, double vision, blindness, deafness, mental disturbance, defective memory, somnolence; symptoms easily explained by the circulation of toxic blood through the nerve centers. These may be preceded by lassitude, and accompanied by constipation, or by diarrhea. Head- ache is perhaps the most significant and common warning symptom. In bad cases the urine is reduced in quantity (almost suppressed), very dark in color, its albumin greatly increased, so that it becomes solid on boiling. Next comes the final catastrophe of convulsions. The convulsive 769 MEDICAL RECORD fit begins with twitching of the facial muscles, rolling and fixation of the eyeballs, puckering of the lips, fixation of the jaws, protrusion of the tongue, etc., soon followed, by violent spasms of the muscles of the trunk and limbs, in- cluding those of respiration ; hence lividity of the face and stertorous breathing, biting of the tongue, opisthot- onus, etc. The fit lasts fifteen or twenty seconds, ending in partial or complete coma, possibly death; or conscious- ness may return, to be followed by other convulsions. 8. See Williams' "Obstetrics" (1909), page 818; or Hirst's "Obstetrics" (1909), page 585. GYNECOLOGY. 1. The pathology of menstruation includes: (1) Pre- mature or precocious menstruation ; (2) protracted men- struation; (3) absence of menstruation (amenorrhea) ; (4) profuse menstruation (menorrhagia) ; (5) flow in between periods (metrorrhagia) ; (6) painful menstruation (dys- menorrhea) ; (7) vicarious menstruation; (8) regular in- termenstrual pain. 2. The most common causes of sterility in woman are : Gonorrhea, absence or errors in development of any part of the genital tract, malformations of genitals, fistulse, lacerations, obesity, alcoholism, pelvic inflammations, dys- pareunia, inflammations of uterus, tubes, or ovaries, elon gated cervix. Treatment consists in removing the cause, if possible; curettage has been recommended; in the pres- ence of developmental errors little or nothing can be done : atresia of cervix can be treated by dilatation ; if the uterus is misplaced it must be replaced. 3. Metritis. Symptoms: Constitutional disturbances, temperature from ioo° to 105 F., chills, pelvic pain, and discharge which may be profuse, offensive, purulent, or blood-stained. The vagina is hot; the uterus is tender, heavy, and bulky ; later it may become fixed ; the cervix is first soft, then hard and firm. Course: If of puerperal origin it may be fatal; otherwise the tendency is to re- covery, after a slow and protracted course. As complica- tions there may be : Pelvic peritonitis and cellulitis, pyosal- pinx, and sterility. The disease may produce backache, leucorrhea, uterine displacements, dysmenorrhea, and steril- ity. Diagnosis can be made from above symptoms and course. 4. Curettage, Indications: For diagnosis, to remove pieces of retained placenta or decidua, endometritis, mucous polypi, hemorrhage, dysmenorrhea, endocervicitis. Dangers: Sepsis, perforation of uterus, hemorrhage, abortion, in- flammation of uterus or adnexa. Procedure: All anti- septic and aseptic precautions are necessary, the patient should be in the dorsal position, the vagina is to be disin- 770 MEDICAL RECORD. fected, and the cervical canal dilated; a speculum is in- troduced into the vagina and the cervix is drawn down with volsella ; the uterine cavity is irrigated with creolin or lysol ; a curette is inserted to the fundus and moved down to the internal os ; the operator should begin at one cornu, and go in the same direction all around till he reaches the starting point, and if necessary repeat till no more spongy or hyperplastic tissue appears ; the fundus should be scraped separately by moving the curette along it from side to side; in going towards the fundus no scraping should be done, and care must be taken not to perforate the uterus; should this happen no fluid must be injected; otherwise the uterus and vagina are again irrigated,, and one or more strips of iodoform gauze are inserted into the cavity to act either .as a hemostatic plug or as a drain, which is diminished with two days' inter- val and withdrawn on the sixth day. A hemostatic tampon should be placed in the vagina and withdrawn the follow- ing day. If any fever arises, the tampon is at once re- moved and the vagina douched with antiseptic fluid every three hours. If not, the vagina is only swabbed with the same every day, and packed loosely with iodoform gauze. After the final removal of the gauze the antiseptic douche is given twice a day until there is no more discharge. NEUROLOGY, DIETETICS, MEDICAL JURISPRUDENCE. i. (a) The neuron, (b) The neuron consists of a nerve cell of variable size, with nucleus, nucleolus, and one or more processes (axis-cylinder or neuraxon, and den- drites), there is no cell wall, and but little chromatin, (r) In acute anterior poliomyelitis, the anterior cornua (espe- cially of the lumbar and cervical enlargement) are specially involved; the anterior roots atrophy. 2. (a) See Cunningham's "Anatomy" (1909), page 452; or Gray's "Anatomy" (1908), page 834. Pia, arachnoid, and dura, (b) To the disc between the first and second lumbar vertebra, (c) In locomotor ataxia the posterior columns, roots, and spinal ganglia are first involved. 3. (a) Seventh, facial; eighth, auditory; tenth, pneumo- gastric; twelfth, hypoglossal, (b) See below, Physiology. Questions 1 and 3. (r) The Gasserian ganglion is on the fifth cranial nerve, and is situated in Meckel's hollow, near the apex of the petrous portion of the temporal bone. 4. (a) See Cunningham's "Anatomy" (1909), page 648; or Gray's "Anatomy" (1908), page 1030. (b) Internal and external popliteal. (c) Anywhere between the sacral plexus and the lower third of the thigh. 5. (a) The pneumogastric and the sympathetic, (b) The- former is the inhibitory nerve and slows the heart ; the latter augments or accelerates the beats. 771 MEDICAL RECORD. 6. When abortion is undertaken by properly qualified physicians after due consultation with other physicians, and for the purpose of saving the life or health of the mother, it is justifiable; under all other circumstances it is criminal. The former is a perfectly lawful medical pro- cedure; the latter is illegal. 7. In expert testimony, the witness may give his opinion on facts or supposed facts as noted by himself or asserted by others. Theoretically, this can be done only by those perfectly familiar with the subject in question; but practi- cally any (or almost any) physician with a license to prac- tice is accepted as an expert witness. In ordinary testimony, the witness testifies to facts which he has seen, or heard, or with which he has become ac- quainted by personal observation. Four positive signs of death; (1) The permanent cessa- tion of circulation; (2) the permanent cessation of respira- tion; (3) rigor mortis; (4) putrefaction. 8. In Wisconsin : The words "insane persons" include idiots, persons non compos mentis, lunatics, and distracted persons. Any three citizens may apply to the county court for a judicial enquiry and an order committing a person to a State hospital. Two physicians are appointed as ex- aminers in lunacy. The form of their report is prescribed. Insane persons may also be admitted as voluntary patients upon two physicians' certificates. — (From Witthaus and Becker's Medical Jurisprudence, etc.) 9. Tissue formers: Lean meat, eggs, wheat. Work and heat producers: Bread, butter, sugar, potatoes. 10. See French's "Practice" (1907), page ill; or Osier's "Practice" (1909), page 99. 11. About 65 to 70 ounces of water are required, besides what is obtained from the food. Four functions of water: (1) It is the chief ingredient of the fluids of the body; (2) it serves as a distributor of body heat; (3) it regu- lates the body temperature (by means of absorptipn and evaporation) ; and (4) it enters into the chemical com- position of the tissues. 12. The fat of the body is obtained from fatty foods, from carbohydrates, and from proteids. In apoplexy the diet must be light, nutritious, and un- stimulating, and consist chiefly of milk and farinaceous foods. Animal food is best avoided, or limited to fish; alcohol, tea, and coffee are also best avoided. A vegetarian and milk diet is best, but individual peculiarities have to be studied. Rectal feeding may be necessary. The reason for the reduced diet is to reduce arterial tension, and so pre- vent a recurrence of the hemorrhage. Intravascular pres- sure must also be kept low, hence too little fluid must not J72 MEDICAL RECORD be given, and the kidneys should be kept active with diu- retics. PHYSIOLOGY, OPHTHALMOLOGY, AND* LARYNGOLOGY. i. Pneumogastric nerve. Superficial origin: Groove between restiform and olivary bodies. Deep origin: Nuclei in floor of fourth ventricle. Distribution is shown by the names of the branches : Meningeal, auricular, pharyngeal, superior and inferior laryngeal, cardiac, pulmonary, esopha- geal, and gastric. Function: It supplies (i) motor influ- ence to the pharynx and esophagus, stomach, and intestines, to the larynx, trachea, bronchi, and lungs; (2) sensory and, in part, (3) vasomotor influence, to the same regions; (4) inhibitory influence to the heart; (5) inhibitory affe- rent impulses to the vasomotor center; (6) excito-secre- tory to the salivary glands; (7) excito-motor in coughing, vomiting, etc. 2. Alcohol excites, then depresses the brain ; in small doses it stimulates the stomach and may help digestion ; later it congests the stomach and liver, over-stimulates the gastric glands and hepatic cells, causes gastric catarrh, produces pathological conditions, and impairs digestion. 3. The facial nerve is the motor nerve of the muscles of expression, also of the platysma and the buccinator; it also supplies the muscles of the external ear, the stylohy- oid, and the posterior belly of the digastric. Through the chorda tympani it is a nerve of taste and a vasodilator of the vessels of the submaxillary and sublingual glands. Hence section of the nerve would cause abolition of these various functions ; notably, facial paralysis would ensue. When it is paralyzed, the muscles of the face being all powerless, the countenance acquires on the paralyzed side a characteristic, vacant look, from the absence of all expression ; the angle of the mouth is lower, and the paralyzed half of the mouth looks longer than that on the other side ; the eye has an unmeaning stare, owing to the paralysis of the orbicularis palpebrarum. All these pecu- liarities increase the longer the paralysis lasts, and their appearance is exaggerated when at any time the muscles of the opposite side of the face are made active in any expression, or in any of their ordinary functions. In an attempt to blow or whistle, one side of the mouth and cheeks acts properly, but the other side is motionless, or flaps loosely at the impulse of the expired air; so, in try- ing to suck, one side only of the mouth acts; in feeding, the lips and cheek are powerless, and, on account of paraly- sis of the buccinator muscle, food lodges between the cheek and gums. 4. A lobule of the liver is about 1-20 to 1-12 inch in diameter. It has a darkish red center and a lighter cir- 773 MEDICAL RECORD. cumference. The center is occupied by an intralobular vein which collects the blood from the capillaries of the lobule, and flows # into the sublobular vein, which latter opens into the hepatic vein. Around the lobules are the interlobular veins; these are branches of the portal sys- tem; capillaries passing from the circumference to the center of the lobule connect the interlobular and intra- lobular veins. Between the network of capillaries in the lobule the hepatic cells are packed. The functions of the liver are: (i) The secretion of bile, (2) the formation of glycogen, (3) the formation of urea and uric acid, (4) the manufacture of heat, and (5) the conversion of poisonous and harmful into inert ma terial. 5. Excess of albuminous food may cause : Congestion and enlargement of the liver, plethora, imperfect oxidation and elimination, delayed metabolism, fever, malaise, diar- rhea, albuminuria, calculus, lithemia, torpor, and bilious- ness. Excess of oleaginous food may cause : Delayed nitrogenous assimilation, production of excessive fat. Ex- cess of farinaceous food may cause : In addition to same as excess of oleaginous food, acidity and flatulence, cor- pulence, enfeebled heart action, dyspepsia, and glycosuria. 6. (a) Inflammation is the series of changes which occur in a part as the result of injury, provided the injury is not so severe as to destroy the tissues; it is the "reaction of the tissues to injury." (h) The functions of the skin are : Protection, sense of touch, excretion, regulation of body temperature, absorption, and respiration. 7. Saliva. Functions: (1) To moisten the mouth; (2) to assist in the solution of the soluble portions of the food, and thus (3) to administer to the sense of taste; (4) to lubricate the bolus of food, and thus (5) to facili- tate the acts of mastication and deglutition, and (6) to change starches into dextrin and sugar. Composition: Water, mucin, ptyalin, potassium sulphocyanide, proteid, sodium chloride, and other salts. Gastric juice. Functions: To convert proteids into proteoses and peptones, to curdle milk. Composition: Water, pepsin, hydrochloric acid, chlorides, and phosphates. Bile. Functions: (1) To assist in the emulsification and saponification of fats; (2) to aid in the absorption of fats; (3) to stimulate the cells of the intestine to increased secretory activity, and so promote peristalsis, and at the same time tend to keep the feces moist; (4) to eliminate waste products of metabolism, such as lecithin and choles- terin ; (5) it has a slight action in converting starch into sugar ; (6) it neutralizes the acid chyme from the stomach, and thus inhibits peptic digestion; (7) it has a very feeble antiseptic action. Composition: Water, sodium glycocho- 774 MEDICAL RECORD. late, sodium taurocholate, lecithin, cholesterin, pigment. and inorganic salts. 8. Use of the ophthalmoscope: "The patient is placed in front of the source of illumination, and to the side of the eye to be examined, the light behind him so that it shines on his temple, just touching the tips of the outer lashes. He is then told to look straight ahead to an object on a level with his eyes across the room. To examine the patient's right eye the surgeon sits or stands, and holds his ophthalmoscope in his right hand before his own right eye. To examine the patient's left eye he places himself to the left of the patient and holds the ophthalmoscope in his left hand before his own left eye. The ophthalmoscope is brought close to the eye under examination, the mirror of the ophthalmoscope having been inclined and the instru- ment held in such position that the light from the source of illumination will be reflected directly into the patient's pupil ; then, if the media are clear, a red glare called the fundus reflex is seen through the hole in the mirror. If the examiner wears glasses, he need not remove them; in fact, if he is astigmatic, he had better accustom himself to working with his correcting lenses on." — (From Gould and Pyle's Compend.) Diseases which can ^ be diagnosed by its use: Brain tumors, abscess of brain, anemia of brain, cerebral aneu- rysm, tabes dorsalis, multiple sclerosis, exophthalmic goiter, nephritis, diabetes, hypertrophy of the left ventricles of the heart, fatty degeneration of the heart, syphilis, alcoholic or tobacco poisoning. g. Iritis. Symptoms: _ Pain, photophobia, small pupil, ciliary congestion, discoloration of iris, exudate in anterior chamber. Treatment: Causal, abstraction of blood from temples, atropine, diaphoresis, shielding the eye from light. Keratitis. Symptoms: Pain, photophobia, ciliary injection, blepharospasm, impairment of vision, cornea may be per- forated. Treatment: Causal, atropine, tonics, and sympto- matic. 10. Hordeolum is an abscess or inflammation in the tissues about the follicle of an eyelash. Chalazion is a tumor in the eyelids due to obstruction of the duct in a Meibomian gland. Ptosis is a drooping of the upper eye- lid, generally due to paralysis. Astigmatism is a condition in which, owing to a greater curvature of the eye in one meridian than in others, the refractive power ot the eye varies. Myopia is a condition in which the anteroposterior axis of the eye is abnormally long, and parallel rays are focused in front of the retina. Glaucoma is a disease of the eye due to increased intraocular tension, and resulting in .excavation and atrophy of the optic disc, and finally blindness. Refraction is the deviation produced in the 775 MEDICAL RECORD course of a ray of light in its passage from one medium to another. Also, the act or process of refracting. n. In diphtheria the onset is more gradual; the tem- perature rises to about ioi° F. ; the tonsils are not much enlarged; there is an exudate of a thick, grayish membrane which is very adherent, is removed only with difficulty, and leaves a bleeding surface; this membrane soon re- forms and may be found on the fauces and pharynx as well as on the tonsils; in the exudate the Klebs-Loeffler bacilli may be found. In follicular tonsillitis the onset is more sudden; the temperature may be a little higher than that of diphtheria ; there is no membrane, but the tonsils are red and swollen, and in the crypts are seen white, cheesy spots or plugs, which consist of broken-down epithelium, and are easily brushed away; Klebs-Loeffler bacilli are never found. 12. See French's "Practice" (1907), pages 645 and 360; or Osier's " Practice" (1909), pages 597 and 600. STATE BOARD EXAMINATION QUESTIONS. College of Physicians and Surgeons of British Columbia. anatomy. 1. (a) Describe the pleura, (b) Give the "reflections of the pleura" of the right side. 2. Name the bones which enter into the formation of the orbit, and give the articulations of any one of them. 3. (a) Give the muscles attached to the great tro- chanter of the femur, (b) Give the action and nerve sup- ply of any two. 4. Trace the seventh nerve; what group of muscles does it supply? 5. Describe the ligaments of the ankle joint and the sternoclavicular joint. 6. Dissection necessary to expose the innominate artery. chemistry and public health. 1. Antidotes—classify and give examples. What is the antidote in a case of acute arsenical poisoning? Give equation showing action. 2. In an analysis of drinking water you find chlorides 2 grs. per gallon. Discuss your results. 3. Describe minutely disinfection of a room occupied by an advanced and careless consumptive. 4. Cows' milk, (a) Discuss its merits as a food, (b) Show how it becomes dangerous for human use when im- properly handled. 776 MEDICAL RECORD. 5. Differentiate between varioloid and chickenpox. MATERIA MEDICA AND THERAPEUTICS. 1. Name two drugs in each of the following orders, stating doses and cases in which either would be used : Emetics, hypnotics, stimulants, diuretics, diaphoretics. 2. Doses and uses : Potassium bromide, strontium iodide, calomel, ichthyol, guaiacol. 3. State briefly in what disturbances of the circulatory system you would use digitalis, adrenalin, strychnine, ergot. 4. Write prescriptions : Acute bronchitis in adult. Acute rheumatism in adult. Acute nephritis, child, aged 12. Diabetes. 5. Describe treatment for typhoid fever. 6. Serum therapy: Nature and value as far as known. MEDICAL JURISPRUDENCE. i. Duties of a medical man when called to a case on which rape is alleged to have been committed. 2. Distinguish between acute alcoholism and acute mania. 3. A case of suspected poisoning. Describe proceed- ings. 4. Antidotes for : Carbolic acid, corrosive sublimate, chloral, arsenic, opium. MIDWIFERY AND DISEASES CF WOMEN AND CHILDREN. 1. What are the causes of delay, from slow dilatation, in the first stage of labor? Give the treatment in each case. 2. Describe the normal anatomy of the Fallopian tube. The varieties, causes, symptoms, prognosis, and treatment of salpingitis. 3. Enumerate the causes of hemorrhage before and after delivery. Give the varieties, causation, symptoms, and treatment of placenta praevia. 4. Name the varieties of displacement of the uterus. The causation and symptoms of retroflexion. Describe the operations performed for retroflexion. ^ 5. Give the etiology, pathology, symptoms, complica- tions, and treatment of a case of cerebrospinal meningitis. PHYSIOLOGY. 1. Describe the cardiac nervous mechanism. 2. What do you know of renal secretion? 3. Discuss absorption in the digestive tract. 4. - State the effect of cutting the third nerve. " Account for the different forms of aphasia. MEDICAL RECORD SURGERY. i. Empyema. Give its causes and treatment. Describe Schede's operation. 2. Prostatectomy. What conditions necessitate this? Describe the technique of the perineal method. 3. Coxalgia. Describe the various stages with symp- toms of each, and appropriate treatment. 4. Describe Sayre's method for fractured clavicle. Give the principles of its action. 5. Hip-joint dislocations. Give the varieties, their symptoms and treatment. THEORY AND PRACTICE OF MEDICINE AND MEDICAL PATHOLOGY. 1. Epidemic cerebrospinal meningitis : Give etiology, symptoms, and differential diagnosis. 2. What is uremia? With what conditions may uremic coma be confused? Give differential diagnosis. 3. Mitral incompetency : Give physical signs and de scribe symptoms as they may arise. 4. Asthma : Give symptoms and treatment. 5. Give pathology, symptoms, and treatment of a case of tuberculous disease of the intestines. ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. College of Physicians and Surgeons of British Columbia. anatomy. 1. "The pleura are two serous sacs enclosing and invest- ing the lungs. Each pleura consists of a visceral and parietal layer. The visceral portion covers the lung, and the parietal layer lines the inner surface of the chest walls, the upper surface of the diaphragm, and the sides of the pericardium. The visceral and parietal layers of the corre- sponding pleura become continuous in front and behind the root of the lung ; and below the root a fold, the ligamentum latum pulmonis, extends downward along the inner sur- face of the lung to the diaphragm. The mediastina are formed by the visceral layers of each side approaching one another toward the median line. "The limits of the parietal pleurae are as follows : Each extends upward into the neck, forming a domelike process over the apex of the lung about two inches above the first costal arch ; from this the pleura passes downward and forward to the posterior aspect of the sternoclavicular joint of each side and meets its fellow in the midline at the manubriogladiolar articulation ; they pass down to- 778 MEDICAL RECORD gether to level of fourth costal cartilages, where right pleura passes vertically to level of seventh right costal cartilage in midline ; then outward, crossing ninth rib in midaxillary line; then downward and backward along eleventh rib to reach spine at neck of twelfth rib. Behind, it passes upward on the right side of the bodies of the vertebrae to the apex." (Aids to Anatomy.) 2. The bones which enter into the formation of the orbit are : The frontal, sphenoid, ethmoid, superior maxillary, malar, lacrymal, and palate. Of these, the malar articu- lates with : The frontal, sphenoid, temporal, and superior maxillary. 3. (a) The muscles attached to the great trochanter of the femur are : The Gluteus medius, Gluteus minimus, Pyriformis, Obturator internus, Obturator externus, Ge- mellus superior, Gemellus inferior, and Quadratus femoris. (b) The Quadratus femoris rotates the thigh outward; it is supplied by branches from the sacral plexus. The Obturator internus rotates the thigh outward ; it is supplied by branches from the sacral plexus. 4. The seventh or facial nerve has its superficial origin in the upper end of the medulla oblongata, in the groove between the olivary and restiform bodies. It passes "for- ward and outward to enter the internal auditory meatus; it lies upon a groove on the auditory nerve, with portio intermedia of Wrisberg between, and at the bottom of the meatus it enters the aqueductus Fallopii, along which it runs first outward between cochlea and vestibule as far as hiatus Fallopii; then backward in internal wall of tympa- num, just above fenestra ovalis, at the turn presenting a swelling, the geniculate ganglion; and finally it passes downward, to emerge from the bone at the stylomastoid foramen ; it then passes outward and forward in the parotid, dividing behind the ramus of the jaw into temporo- facial and cervico-facial branches, which further subdivide and intercommunicate, forming the pes anserinus! } (Aids to Anatomy.) It supplies the muscles of expression in the face, the muscles of the external ear, the Platysma, Buccinator. Stylohyoid, and the posterior belly of the Digastric. 5. The ligaments of the ankle joint are : The anterior tibio-tarsal, posterior tibio-tarsal, internal lateral, and external lateral. The ligaments of the sternoclavicular joint are : The anterior sternoclavicular, posterior sternoclavicular, inter- clavicular, costoclavicular, and interarticular fibrocartilage. For description see Cunningham's "Anatomy" (1909). pages 306 and 273; or Gray's "Anatomy" (1908), pages 349 and 299. 6. See Gray's "Anatomy" (1908), page 597. 779 MEDICAL RECORD CHEMISTRY AND PUBLIC HEALTH. i. Antidotes are classified as: — (i) Chemical antidotes, which act by uniting chemically with the poison and thus converting it into a harmless or insoluble compound. Ex- ample: Albumin, in mercurial poisoning; sodium sulphate, in carbolic poisoning. (2) Physiological antidotes, which act by combating one (or more) of the physiological actions of the poison. Example : Opium will counteract the dilated pupil caused by belladonna. * The antidote for acute arsenical poisoning is freshly prepared solution of ferric hydroxide. The equation show- ing the action is : As 2 3 + 2 Fe 2 (OH) 6 = Fe(OH) 2 + 5 H 2 + Fe 3 (AsO*) 2 2. Two grains of chlorine per gallon is not an excessive amount for many localities ; but some writers recommend the condemnation of all waters containing more than one grain to the gallon of water. As a rule the chlorine de- notes animal organic impurities. 3. Room disinfection: 'This can only be carried out ef- fectually when the room is unoccupied; therefore the first essential is evacuation, next all articles that can be disin- fected by moist or dry heat or by soaking in some chemical disinfectant should be removed and treated accordingly. All windows, chimneys, and orifices having been closed as tightly as possible and all cupboards and drawers opened and exposed, the space or chamber should be fumigated in presence of moisture with either formaldehyde, chlorine, or nitrous acid for at least three hours. On reentering, open all doors and windows, and strip the walls of paper, burn the pieces, have the ceiling well limewashed, and scrub all floors, all woodwork and furniture with either plain hot water and soft soap, or with bichloride of mercury (1 in 1000), or with formalin (2 per cent). In many cases ade- quate disinfection will be secured by free perflation of air, and, in place of fumigation, the free use of a spray of either formalin or chinosol or mercuric chloride in proper proportions to the surfaces of walls and furniture. We are disposed to consider this application by sprays of these disinfectants directly to infected surfaces as of far greater value than attempts to disinfect by gaseous means; it is the place itself, not the air of the place, we need to disin- Lct; the air can be readily changed by free ventilation." — (Notter and Firth's Hygiene.) 4. Cow's milk is a perfect food for very young children ; but for those who are older, it is not so satisfactory, be- cause such enormously large quantities would have to be taken to ensure an adequate supply of nitrogen and carbon. Diseases Connected with Milk— -Milk has the power of absorbing gases and vapors to a great extent, and if 780 MEDICAL RECORD. these are offensive or noxious they will produce their effects on the body. It also very readily passes through the lactic and butyric fermentation to putrefaction. Stomatitis, gastric and intestinal irritation, etc., are pro- duced by milk containing lactic acid, or fungi, or pus, etc., from an inflamed or suppurating udder. The germs of tuberculosis, enteric fever, scarlatina, diph- theria, anthrax, and foot-and-mouth disease, whether in- troduced directly from the cow, from the hands of the milkers, from the water used to wash the milk-cans or to dilute the milk, or absorbed from the air — find in milk a suitable culture medium in which they multiply and by which they are conveyed. Milk which has been kept for some time may develop a ptomaine called tyrotoxine, or cheese poison ; it has been detected in ice creams, which have proved to be poisonous. 5. In varioloid: There is premonitory discomfort, no- ticeably pain in the back; there may be a marked initiatory fever; the rash does not appear till the third day, is shotty, is most marked on the face and wrists ; vesicle formation is delayed, the vesicles have a central depression which is well marked; the fever subsides as the eruption appears. In chickenpox : There is little or no premonitory dis- comfort; fever is slight; the eruption appears in about 24 hours, is not shotty, is scattered generally all over the body; vesicles form in a few hours, and umbilication appears late or not at all, and the vesicles rapidly become scabbed. MATERIA MEDICA AND THERAPEUTICS. I. ORDERS DRUGS DOSE Emetics. 1. Apomorphine hy- gr. 1/10 (hypodermic- drochloride. ally.) 2. Wine of ipecac. 3ij — iv. Hypnotics. 1. Chloral hydrate. gr. xxx. 2. Sulphonal. gr. xxx. Stimulants. 1. Aromatic spirit of ammonia. 3j. 2. Strychnine sulphate gr. 1/30. Diuretics. 1. Potassium acetate. gr. xxx. 2. Citrated caffeine. gr. v. Diaphoretics. 1. Pilocarpine hydro- chloride. gr. 1/5. 2. Liquor ammonii acetatis. 3iv. 2.- Potassium bromide, gr. xv. ; strontium iodide, gr. vij ; calomel, gr. i; ichthyol. gr. x; guaiacol, ttpviij. 781 MEDICAL RECORD Potassium bromide is used in epilepsy, insomnia, hys- teria, neuralgia, nervousness, migrane, seasickness, deli- rium tremens. Strontium iodide is used in syphilis, gonorrheal rheu- matism, joint diseases, pleurisy, arteriosclerosis. Calomel is used as a purgative, intestinal antiseptic, in in- flammations, syphilis, as a dusting powder for venereal ulcers. Ichthyol is used for inflammations, swellings, eczema, erysipelas, psoriasis, ulcers, burns. Guaiacol is used in phthisis, diabetes, typhoid. 3. Digitalis is indicated in diseases of the heart, (1) when the heart action is rapid and feeble, with low arterial tension ; (2) in mitral lesions when compensation has begun to fail; (3) in nonvalvnlar cardiac affections; (4) in irritable heart, due to nerve exhaustion. Digitalis is con- traindicated in diseases of the heart (1) in aortic lesions when uncombined with mitral lesions; (2) when the heart action is strong and arterial tension high. Adrenalin is indicated in hemorrhage from different parts, in purpura and in hemophilia. Strychnine is indicated in cardiac failure and when a cardiac stimulant is required. Ergot is indicated in arterial hemorrhage (particularly postpartum hemorrhage), hemoptysis, aneurysms, and it also acts as a cardiac sedative. 4. For acute bronchitis : B. Vini ipecacuanha? 3ij Liquoris potassii citratis 3iv Tincturse opii camphoratse. Syrupi acaciae aa 5J Misce. Signa — One tablespoon ful three times a day. For acute articular rheumatism : B. Sodii salicylatis . . . .3ijss Fluidextracti glycyrrhizae. Tincturse aurantii aa 5ijss Aquae chloroformi q.s. ad Jviij Misce. Signa: Take two tablespoonfuls every four hours. For acute nephritis, in a child, aged 12 : 5- Tincturae jaborandi 5iv Sodii benzoatis 3ii Aquae chloroformi q.s. ad Jiij Misce. Signa : One teaspoonfnl three times a day. For diabetes : ty„ Codeinae .= .■ .gr. xij Extracti nucis vomicae gr. ii j Extracti rhamni purshianae gr. vj Misce., et fiat massa in pilulas no. xij dividenda. Signa : Take one, three times a day, 782 MEDICAL RECORD 5 See French's /'Practice of Medicine 55 (1907), page 109; or Osier's "Practice of Medicine" (1909)5 page 99. 6. "Serum therapy proper is the prophylactic and cura- tive treatment of certain infectious diseases by the subcu- taneous or intravenous administration of a blood serum containing an antibody which is specific to the particular disease/ 5 (Potter's Materia Medica.) Examples: (1) Diphtheria antitoxin; dose, 3,000 units; immunizing dose, 500 units; indicated in diphtheria; (2) antitetanic serum; dose, 3ijss to v; indicated in tetanus; (3) antivenomous serum; dose, 3ijss to viij ; indicated in snake bite. MEDICAL JURISPRUDENCE. i. The physician should note date and time when he is called; he should (with her consent) examine the female, and if possible also the accused, and note (1) marks of violence about the woman's genital organs ; (2) wounds, bruises, or other marks of injury on the woman or on the accused; (3) blood stains and seminal stains on the person or clothing of either party; and (4) the presence of any venereal disease on either party. He should be careful to say nothing, hear everything, and, above all, to avoid saying a rape has or has not been committed. The question of "consent" enters into the sub- ject, and the physician has no means of knowing whether or no this was given. 2. For symptoms of acute alcoholism, see French's 'Practice of Medicine" (1907), page 953. In mania, the body temperature is generally raised, and the skin dry and hot, the eye is apt to have a fixed and wild or brilliant >tare. 3. "First of all, the physician should keep his suspicions to himself. In the next place, he should himself test the urine or feces, or both, and govern his treatment and his actions toward the patient and those surrounding the patient by the results of his examination. Should the case terminate fatally, he should at once communicate his sus- picions to the prosecuting officer, and require a post-mortem investigation, which should, if at all possible, be conducted in the presence of the chemist who is to conduct the analysis, "The following portions of the cadaver should be pre- served : — The alimentary canal from the cardia to the middle of the rectum, unopened, and the contents enclosed by ligatures at the esophagus, duodenum, and lower end of gut; the liver, including the gall-bladder; one kidney; the spleen; a piece of muscular tissue from the leg; the brain, and any urine which may remain in the bladder. "Any inspected food articles, and any obtainable vomited 783 MEDICAL RECORD. matter, are to be also preserved. All of these are to be placed in clean and new glass jars, closed with glass or cork covers or stoppers. Jars with metallic caps should never be used. Tapes or cords should be tied about the jar and cap, to which they should be attached by sealing wax bearing impressions of a seal, in such a manner that access can be had to the interior only after breaking the seals or cutting the tapes or cords. Great care must be exercised that no sealing wax can get into the jars. Each portion should be placed in a jar by itself. " (Witthaus' Essentials of Chemistry and Toxicology.) 4. The antidote for carbolic acid is : A soluble sulphate, or alcohol; for corrosive sublimate, white of egg in mod- erate quantity; for chloral, there is no chemical antidote; for arsenic, freshly prepared ferric hydroxide; for opium, dilute solution of potassium permanganate. MIDWIFERY, AND DISEASES OF WOMEN AND CHILDREN. i. See Williams' "Obstetrics" (1909), page 658; or Hirst's "Obstetrics" (1909), page 439. 2. See Cunningham's "Anatomy" (1909), page 1185; or Gray's "Anatomy" (1908), page 1510. " Salpingitis may be acute or chronic, and is usually due to gonorrtea, septic infection, subinvolution, laceration of the cervix, fibroid tumors, or uterine displacements. ''The symptoms of the acute form are pain in the ovarian region, rise of temperature, increased pulse-rate, and ten- derness, fulness, and enlargement upon vaginal examina- tion. The symptoms of the chronic form are pain, worse upon exercise, defecation, coitus, or exertion of any kind, dysmenorrhea, menorrhagia, and sometimes absolute ster- ility. The uterus is usually displaced backward, and the enlarged and indurated tube may be found behind or be- side it. "The treatment of the acute form consists in rest in bed, free purgation with Rochelle salts (3 1 every hour), hot vaginal douches, and hot applications to the abdomen. If the symptoms become more severe, celiotomy is indicated. The chronic form may be treated during the menstrual period by rest in bed, free purgation, hot vaginal douches, local applications of iodin to the cervix and vaginal vaults, and ^lycerin tampons. If these measures fail, removal of the tube and ovary and replacing the retroverted uterus, etc., are necessary." — (Gould and Pyle's Pocket Cyclo- pedia.) Varieties: Hematosalpinx, when tubes are distended with blood; pyosalpinx, when they contain pus; hydrosalpinx, when they contain serous fluid or exudate. 3. The following (from Gould and Pyle's Cyclopedia of 784 MEDICAL RECORD. Medicine and Surgery) is a useful classification of the hemorrhages in question : A. Hemorrhages of Pregnancy: Caused by (i) placenta prsevia; (2) premature separation of a normally situated placenta; (3) apoplexy of the decidua or placenta. B. Hemorrhages of Labor: Caused by (1) placenta praevia; (2) premature separation of a normally situated placenta; (3) relaxation of the uterus; (4) laceration of the cervix; (5) rupture or inversion of the uterus. C. Hemorrhages of the Puerperium: Caused by (1) retained secundines ; (2) displaced uterus; (3) displaced thrombi; (4) fibroid tumors; (5) hypertrophied decidua; (6) carcinoma. 4. The varieties of displacement of the uterus are : Retro- version, retroflexion, anteversion, anteflexion, lateral ver- sion, lateral flexion, descent or prolapse, ascent, and mal- location (to front, back, or one side). The causes of retroflexion are : Distended bladder, retro- uterine peritonitis ; chronic cystitis ; small fibroid in poste- rior wall of uterus ; too long a period in the recumbent position after labor, or too tight bandaging; tight lacing; infection during puerperium; pressure of tumors; inflam- mations of uterus and its appendages ; gonorrhea. The symptoms of retroflexion are: Bladder disturbances; constipation and painful defecation ; dysmenorrhea, or amenorrhea, or hemorrhages from the uterus ; leucorrhea ; sterility, or frequent abortion. The operations performed for retroflexion are : Breaking up any adhesions that may be present, and then shortening the round ligaments (Alexanders operation, or some mod- ification of it) ; suspension of the uterus (hysterorrhaphy, hysteropexy, ventral fixation, abdominal fixation or sus- pensio uteri) ; vaginal hysterorrhaphy is also done occa- sionally. 5. ^ee French's "Practice of Medicine" (1907), page 139; or Osier's "Practice of Medicine" (1909), page 158. PHYSIOLOGY. 1. The nerves which control the heart are: (1) The pneumogastric nerve, which slows or inhibits the heart beats; (2) the sympathetic nerves, which accelerate or aug- ment the beats ; and (3) the intrinsic cardiac ganglia, which enable the heart to continue beating for some time after it is removed from the body. 2. The mechanism of the secretion of urine by the kid- neys is twofold: (1) By filtration, most, if not all, of the fluid is eliminated, and also inorganic salts ; this depends upon blood pressure, and takes place in the glomeruli. (2) By cell activity and selection, in the cells of the convoluted tubules, the urea and principal solids are eliminated. 785 MEDICAL RECORD. 3. Substances that may be absorbed in the stomach are : Water, alcohol, salts, sugars, and dextrins that may have been converted from starch by the ptyalin of the saliva, and proteoses and peptones resulting from peptic digestion of proteids. In the small intestine, sugars, proteoses, peptones, fats, water, and salts are all absorbed. In the large intestine, water, salt, sugars, proteids, and fats are all absorbed. 4. Cutting the third nerve will produce: Ptosis of the upper lid, external strabismus, slight prominence of the eyeball, dilatation of the pupil, and loss of the power of accommodation. 5. "The speech areas, four in number and in kind, are in the left hemisphere in righthanded persons and in the right in lefthanded persons. There are two types of aphasia, which is the loss of the power of speech, known as motor and sensory aphasia. The motor speech center lies in the posterior part of the third frontal convolution (Broca's convolution), just in front of the center of the muscles of speech (hypoglossal and facial nerve centers). A lesion of the motor speech center causes motor aphasia, in which there is a loss of the word-forming power, although the tongue is movable and the patient may understand spoken and written language and knows what he wants to say. It is as if memory of the motor combinations essential to produce speech were lost. "The power of writing is usually lost with motor speech. The probable location of its cortical center is in the poste- rior two-thirds of the first, and perhaps in the second, tem- poral convolution. A lesion here causes 'word deafness/ a sensory aphasia in which the memory of the sounds of words is lost so that they are not understood, though hear- ing may be normal. "The visual speech center lies in the posterior part of the angular gyrus in the outskirts of the higher visual or the visuopsychic field. Word-blindness (alexia), or the loss of memory of printed or written language, is caused by a lesion here, though sight itself may be normal. "Thus the basis of language is a series of memory pic- tures (1) of the sound of words; (2) of their appear- ance; (3) of the effort necessary to enunciate them, and (4) to write their symbols. As these memory pictures are connected with each other and with others that make up the concept by subcortical asssociation fibers passing be- tween them, a lesion in any of these association tracts also leads to a defect of speech." (Woolsey, Applied Surgical Anatomy.) 786 MEDICAL RECORD. SURGERY. i. Empyema. — Causes: Wounds, injuries, pleuropneumo- nia, direct extension of a suppurative process in the lung, abdomen, or neck. The bacteria will vary with the cause ; diplococcus pneumoniae is the commonest; tubercle bacillus, staphylococcus, streptococcus, colon bacillus may also be present. Treatment: Aspiration, drainage, irrigation, resection of ribs (Estlander's operation), or resection of chest wall (Schede's operation). See Rose and Carless' "Surgery'" (1908), page 929; or Da Costa's "Surgery" (1908), page 786. 2. Conditions which necessitate prostatectomy : Marked enlargement of the prostate gland (when catheterization is painful, difficult, or impossible ; when cystitis is imminent, and when the patient is comparatively young). See Rose and Carless' "Surgery" (1908), page 1230; or Da Costa's "Surgery" (1908), page 1191. 3. Coxalgia. — There are three stages. The first is the stage of synovitis, prior to the development of pus in the joint. The second is the stage of destruction of cartilage and ligaments, and continues till the development of pus outside the joint. The third is the stage of destruction of the bone. Symptoms of first stage: Night cries; lameness in the morning; a slight limp; tendency to become tired on slight exertion; wasting; spasm; pain; swelling; and deformity (either real or apparent). Symptoms of second stage: Abduction; limping; pain, which is worse at night ; apparent lengthening of the limb ; abscess ; atrophy of thigh muscles ; flexion of thigh ; effu- sion into hip joint ; and there may be crepitation in the joint. Symptoms of third stage : Flexion, adduction, and short- ening of the limb; the joint may be dislocated or anky- losed, or suppuration may occur. Treatment: See Rose and Carless' "Surgery" (1908), page 685; or Da Costa's "Surgery" (1908), page 556. 4. Sayre's method for fractured clavicle : "Sayre's dress- ing consists of two strips of adhesive plaster three and a half inches wide and two yards in length. The first strip is looped around the arm just below the axillary margin and is pinned or sewed with the loop sufficiently open not to constrict the arm. The arm is then drawn downward and backward until the clavicular portion of the pectoralis major muscle is put sufficiently upon the stretch to over come the action of the sternocleidomastoid muscle, and in this way draws the sternal fragment of the clavicle down to its place. The strip of plaster is then carried completely 787 MEDICAL RECORD. around the body and pinned or stitched to itself on the back. The second strip is next applied, commencing on the front of the shoulder of the sound side ; thence it is car- ried over the top of the shoulder diagonally across the back, under the elbow, diagonally across the front of the chest to the point of starting, where it is secured by pinning or sewing. A slit is made in this strip to receive the point of the elbow. Before the elbow is secured by the plaster it should be pressed well forward and inward." (Wharton's Minor Surgery, and Bandaging.) The action of the dress- ing is simply to press the shoulder upward and backward. 5. Hip- Joint Dislocations. — Varieties — Backward: (1) On to the dorsum ilii; (2) on to the sciatic notch. For- ward: (3) On to the obturator foramen; (4) On to the pubis. Dorsal dislocation: Head of femur lies on the dorsum ilii, and can be felt in the buttock. The obturator internus is ruptured in most cases. The short rotator muscles are lacerated. The trochanter lies well above Nelator's line and approximated to the anterior superior iliac spine. The leg is shortened two to three inches. The iliotibial band is relaxed. The leg is flexed, adducted, and inverted. The femur crosses the lower third of the opposite thigh. The toe rests on the opposite instep. A hollow exists in Scarpa's triangle. Sciatic dislocation : Similar to the above, except in the following: — The obturator internus tendon is intact and lies over the neck of the femur, holding it down in the sciatic notch. Shortening amounts only to one inch or less. The axis of the femur crosses the opposite knee. The great toe rests on the dorsum of the opposite great toe. Treatment of the backward dislocations: Flex the knee and thigh in position of adduction. Abduct the thigh and evert simultaneously. Bring the leg down straight. "Lift up, bend out, roll out." Obturator dislocation : The head of the bone lies on the obturator externus in the obturator foramen. The adductor muscles are lacerated. The trochanter is obscured, the iliotibial band is tense. The leg is lengthened, the toes point forward and outward. Flexion, abduction, and rota- tion outward are well marked. The head of the femur is felt in the perineum. The capsule is torn in its lower part. Pain referred to the distribution of the obturator nerve. Pubic dislocation: Similar to the above except: The femoral head is felt under Poupart's ligament. The leg is shortened about one inch. Abduction and eversion are more marked, the toes pointing outward. Treatment of forward dislocations : Thigh is flexed in a position of abduction. Adduct the thigh and then invert it. 7B8 • _"* ■■Si (J co C'XI £ . s.2 £ •- <« o o * 3 • O 4> > U CO 00 13 >> XJ . W 2 >, & S- &£ .2^ . 3 ^.^ "tiwO ^ g e . g « 3 3 -co 73 w. O SS.2 > 3^ o £ S o 5 3 S ° 3 ° 13 J3 3 SJ rt rj o ^coS^ fgco 3-mh ^ ^ ^ ^gs :§ §- « ,n « rtco . _, 3 | ^g o c - n •? 3 So 2 i2 4» Sgig s § oS -B|g JiS.SJ 5 ■= |1 lis u-i **$ tu 1 Mill- 5 §1 a 9-9 IbK "81 S S.- 5 U X H. CO _ - JJ c m V ■i. _ - V ~ (4 T3.2,^ v-i3 TPOS bCco-M*2 C 33| 0i>0 »-a -3 a- rt.3 ^OS O tj - %£ TS CU "* ft) «3 t) — i : i. :- «s;-g S £2 > ° "3 S e § « S°^ > 3 a: > »5 3 C3"b££ O ^^ S mi C ^" |lllI1-l 1 lifs |li Mali MEDICAL RECORD. Bring the thigh down straight, ''Lift up, bend in, roll in." (From Groves* Synopsis of Surgery.) THEORY AND PRACTICE OF MEDICINE, AND MEDICAL PATHOLOGY. i. See French's "Practice of Medicine" (1907), page 139; or Osier's "Practice of Medicine'' (1909), page 158. 2. See French's "Practice of Medicine" (1907), page 887; or Osier's "Practice of Medicine" (1909)., page 683. 3. The table on page 789 (from Eisendrath's Surgical Diagnosis) gives the diagnosis. See French's "Practice of Medicine" (1907), page 577; or Osier's "Practice of Medicine" (1909), page 805. 4. See French's "Practice of Medicine" (1907) page 659; or Osier's "Practice of Medicine" (1909), page 610. 5. See French's "Practice of Medicine" (1907), pages 380 and 394; or Osier's "Practice of Medicine" (1909), pages 202. 340, and 352. STATE BOARD EXAMINATION QUESTIONS. College of Physicians and Surgeons of Ontario. anatomy, descriptive. (All questions of equal value. Any five questions to be answered, but not more than five.) 1. Describe (a) the upper extremity, (b) the lower extremity, (c) ossification of the ulna. 2. Describe the shoulder joint, as to (a) articulating surfaces, (b) ligaments, (c) synovial membranes, (d) nerve supply, (e) blood sugply, (/) movements. 3. Name and give origin; insertion, nerve supply, and actions of the muscles of mastication. 4. Describe the lymphatic vessels, and lymphatic glands of the thorax. 5. Describe the prostate gland under the following heads: (a) size, (b) situation, (c) structure, (d) blood supply, (e) relations. 6. Describe the middle ear. 7. Trace the course; give the relations; name and trace the branches of the posterior tibial artery. 8. (a) Describe the sacral plexus and show its method of formation, (b) Trace the great sciatic nerve to its ter- mination. 9. Describe (a) the fornix, (b) corpora quadrigemina, (c) opercula insulse, (d) velum interpositum. 10. Describe the capsules, as to (a) size, (b) situation, (c) structure, (d) relations, (e) blood supply, (/) nerve supply. 790 MEDICAL RECORD PHYSIOLOGY AND HISTOLOGY. i. Give an account of the histological structure of the retina. What portion of the retina is concerned in most acute vision? What is the "blind spot"? 2. Give an account of the histological structure and function of the suprarenal bodies. 3. Describe the development of the lungs. What if meant by the terms residual air and vital capacity? 4. What physical and chemical changes take place in a muscle during contra ::: : n ": 5. What is the normal arterial blood pressure? Discuss the factors which maintain and alter this pressure. CHEMISTRY. (All questions of equal value. The first four questions to be answered, and any two of the remaining four.) 1. Explain folly what is meant, when we say nitrogen is a triad. What is the atomicity of the oxygen and the ozone molecule, and why? 2. One gram of phosphorus is to be converted into the pentachloride. how many litres of chlorine at 15 degrees C. and 780 mm. are required ? 3. Compare the physical and chemical properties of sodium and silver, mentioning the group of metals to which each belongs, and why. 4- Define the term paraffin. Give the names of the acids corresponding to the first, second, and third members of the paraffins, and compare their percentage of compo- sition. 5. Define an amine, an amide, and an imide, and men- tion a member oi each group. 6. Give the names and chemical formulae for bluestone, red precipitate, white vitriol, aqua fortis, mirbane, gun- cotton, cresol, and urea. 7. To what series of organic acids do each of the fol- lowing belong: name! tic oxalic, lactic, and tartaric acid? Give the general formula for each series. 8. How vou proceed to estimate the total nitro- gen in 10 c.c. of urine by either the Kjeldahl or the Gun- ning method? Describe the procedure in detail of the method you select, mentioning the apparatus and reagents e:essary. Atomic Weights.— Chlorine = 35. 5; phosporus = 31; sodium = 2Z\ silver = 108; nitrogen = 14; hydrogen = 1 ; oxygen = 16; carbon = 12.) MATERIA MEDIC A AND PHARMACOLOGY. :tions of equal value. Answer any five of the six question MEDICAL RECORD i. Give preparations of, with quantities: (a) A normal salt solution, (b) A one to two thousand bichloride of mercury solution, (c) A 2}4% solution of carbolic acid. (d) Lime water, (e) A nutrient enema. 2. Define with example, styptic, specific, collyrium, alkaloid, alterative. 3. Compare as hypnotics, morphine, chloral hydrate, and sulphonal. Explain antagonism of morphine and atropine. 4. Outline a prescription containing a mineral acid, a nux vomica preparation, and a pepsin preparation. 5. State ordinary or other names for phenol, acetanili- dum, nitroglycerinum, hydrargyri subchloridum, pulvis ipecacuanhas compositus. Give dosage and specific action (shortly) of each. 6. Select a nitrate, a salicylate, a ferrum, an arsenicum, and an iodidum preparation. Give dose and method in de- tail of prescribing each. THEORY AND PRACTICE OF MEDICINE. i. Give the etiology, pathology, and symptoms of tabes dorsalis. 2. Describe a Flint's murmur and the supposed carse of its production. From what other murmur must it be dis- tinguished, and how? 3. Describe chronic uremia, with reference to its oc- currence, clinical features and treatment. 4. Give the causes and general symptoms of obstructive jaundice. 5. Give the etiology, clinical history, and physical signs of empyema. Name the chief modes of natural cure. PATHOLOGY. 1. Discuss the causes and formation of stricture of the urethra. Explain the pathological conditions which may result from it. 2. What are the features which differentiate innocent from malignant growths? Give the gross appearance and microscopic structure of adenoma, or of a glioma. 3. Give the morbid anatomy of bone lesions in hereditary syphilis, and differentiate these from rachitic and tuber- culous lesions. 4. Discuss the forms of puerperal infection and the usual modes of entry to the system. Name the lesions which may be produced, and describe briefly the pathology of any one of these lesions. BACTERIOLOGY. 1. Explain the difference between active and passive immunity. Illustrate by example how each may be ac- quired. 792 MEDICAL RECORD. 2. Describe Bacillus anthracis under the following heads : morphology, staining, cultural characters, and patho- genicity. THERAPEUTICS. i. Give the treatment of a case of acute rheumatic fever. 2. State the therapeutic uses of ergot. Discuss its use in (a) hemoptysis, (&) hematemesis. 3. Angina pectoris: Give treatment during paroxysm, and in the intervals. 4. Give the treatment of a case of tuberculous peri- tonitis. MIDWIFERY, OPERATIVE. 1. The head is lying in the right oblique diameter of pelvis, with the occiput pointing posteriorly: (a) Give the position of all the landmarks on making a vaginal examina- tion, (b) How may this case end? (c) Treat the case if Nature's efforts are not successful. 2. Diagnose a breech. How would you break up a Frank breech? 3. I have diagnosed a case as transverse presentation with the back of the child pointing towards the mother's feet. I am going to perform version: (a) What foot will I grasp? Why? (b) How would you deliver this after- coming head? 4. Give the symptoms of placenta prsevia, and prema- ture separation of the normally implanted placenta. Make a differential diagnosis. MIDWIFERY, OTHER THAN OPERATIVE, AND PUERPERAL DISEASES. 1. Name the diseases in the mother liable to injure the fetus in utero, and enumerate the supposed causes of labor at full time. 2. Give the causes of post partum hemorrhage and the systematic line of treatment to follow. 3. Give the necessary advice to a patient in a case where you suspect eclampsia might supervene. 4. Treat a case of acute infantile colic. 5. What significance would you attach to the discharge of amniotic fluid tinged with meconium : (a) Breech pres- entations : (b) vertex presentations. SURGERY, OPERATIVE. (All questions of equal value. Any five questions to be answered, but not more than five.) 1. Scirrhus of the mammary gland : Describe minutely the operation necessary for complete removal. 2: For what conditions would you do excision of the elbow? Describe the operation. 793 MEDICAL RECORD 3. What symptoms in a movable kidney render opera- tion advisable? Describe one method of operation for same. 4. What conditions require, and what is the usual method of performing (a) thoracentesis; (b) resection of ribs. 5. Describe the suprapubic and perineal operations for removal of enlarged prostate. Give reasons for your pref- erence in choice of operation. 6. Describe one method of performing colostomy. Give reasons for your choice of operation. State conditions for which the operation may be required. SURGERY., OTHER THAN OPERATIVE. (All questions of equal value. Any five questions to be answered, but not more than five.) 1. Define septicemia and pyemia. Distinguish between them ; give bacteriology, clinical history, symptoms, diag- nosis, and treatment of each. 2. What is tetanus? Give predisposing and exciting causes, clinical history, diagnosis, and treatment. 3. Describe acute infective osteomyelitis. Discuss its clinical history and treatment. 4. What is aneurysm? Describe its structure. Describe popliteal aneurysm, and give its diagnosis and treatment. 5. What are the general principles governing the treat- ment of fractures at or near joints? Describe Colles' frac- ture, and give treatment. 6. Describe the clinical history of a case of enlarge- ment of the prostate gland. Describe the general principles of treatment, apart from the operative. MEDICAL AND SURGICAL ANATOMY. i. Where would you map out the position of the fol- lowing structures on the surface of the skull : (a) the middle meningeal artery, (b) the fissure of Rolando, (c) lateral sinus. 2. Where are the reflex centers for the bladder, rectum, ankle clonus, knee jerk, for wrist and elbow jerks? 3. What enters into the formation of the wrist joint? 4. Describe Colles' fracture, Pott's fracture, and de- formity in each. 5. What anatomical relations may be determined under normal conditions by a digital examination of the rectum? (a) in the male, (b) in the female? 6. Give a description of the normal uterus with appen- dages, as to size and position. 7. Give in some form, the parts cut through in ampu- tation o f the leg, upper third, and name of main vessels tied, and where found. 794 MEDICAL RECORD. 8. What tumors may be found in the right and left inguinal region and in hypogastric regions? 9. Describe Scarpa's triangle, boundaries, and of what importance is it surgically? 10. Give the collateral circulation after ligature of the femoral artery in Hunter's canal. MEDICAL JURISPRUDENCE. 1. On opening the thorax for a postmortem, what pre- caution is to be observed? 2. With regard to the external appearance of the heart, what important condition is to be observed? 3. After the removal of the heart, how would you make your incision to examine the interior? 4. Death by suffocation, how is it produced? 5. Give the average weight in an adult of brain, heart, spleen, liver, and kidney. TOXICOLOGY AND MENTAL DISEASES. 6. Give (a) Symptoms of a cocaine poisoning, (b) Period when fatal, (c) Fatal quantity. 7. What are the special indications of mental weakness. 8. Distinguish between opium poisoning, acute alcohol- ism, epilepsy, and cerebral hemorrhage. SANITARY SCIENCE. 1. (a) What becomes of the rain that falls during the year? (b) What are the objections to using rain water, as it falls, for domestic purposes? 2. (a) What are the different sources for water sup- ply? (b) Describe three different methods of purifying water for domestic use. (c) Name objections to storing water in cisterns, (d) How should a cistern be constructed to permit of the safe use of water thus stored? 3. Name the diseases caused by the use of impure water. 4. What do you understand by the term inspection, flushing, and ventilation of sewers? 5. Describe purification and utilization of sewage. 6. Name (only) the methods by which air is vitiated. 7. What are the advantages of a mountain climate, as contrasted with those of the plains? N. B. — Any of the above questions can be answered in thirty words. THERAPEUTICS. I. What are the indications for the use of belladonna (a) externally, (b) internally? Give the symptoms and treatment of an overdose. 2.- Describe fully the treatment for ascites, giving rea- sons for each measure employed. 795 MEDICAL RECORD. 3. In a case of deranged heart action, state fully the indications for the employment, respectively, of (a) digi- talis, (b) strophanthus, (c) strychnine, (d) nitroglycerin. 4. Write prescription for each of the following condi- tions : (a) pleurisy with effusion, (b) suppression of urine, (c) sciatica, (d) alkaline cystitis. , DISEASES OF WOMEN. 1. In making the incision to perform abdominal hyster- ectomy, you accidentally open the urinary bladder for two inches in extent. Describe in detail your method of repair. What suture material would you use? Would you repair immediately, or at the conclusion of the hysterectomy? What after treatment would be necessary? 2. Give the causes and treatment of pruritus vulvae. 3. Describe the operation for, and the after-treatment of, repair of complete perineal rupture — say eight months after confinement. 4. A mass the size of a small orange is found in the posterior cul-de-sac; differentiate between retrodisplaced uterus, fibroid of the uterus, and ovarian cyst. 5. In using the uterine sound give the : (a) preliminary preparation, (b) indications, (c) contraindications, and (d) dangers. DISEASES OF CHILDREN. 1. Define laryngismus stridulus (spasmodic croup), and give the predisposing and exciting causes, symptoms, the diseases for which it may be mistaken, and its treatment. 2. Discuss briefly the diagnostic values of Kernig's and Babinski's reflexes. What change, if any, occurs in the patellar reflex (knee jerk) in lobar pneumonia? 3. Diagnose and treat a case of acute rheumatic endo- carditis in a child ten years old. 4. Acute osteomyelitis : (a) Name in order the three most common infecting germs, (b) the three bones in which it most frequently occurs, (c) and the diseases for which it may be mistaken. What would be your treatment of an acute attack of the very early stage of the disease, as soon as you felt fairly sure of your diagnosis? 5. A child 4 years old receives a penetrating wound of the brain from the tine of a pitchfork. The point of entry is one inch above the meatus auditorius externus, and the fork goes straight in, horizontally, to a depth of three inches or half-way through the brain. Name in some order the structures that would be pierced. What symp- toms would likely follow and the treatment from the beginning to the end of the case. 796 MEDICAL RECORD ANSWERS TO STATE BOARD EXAMINATION QUESTIONS. College of Physicians and Surgeons of Ontario. anatomy, descriptive. 1. See Cunningham's "Anatomy" (1909), pages 1291, 1302, and 197; or Gray's "Anatomy" (1908), pages 169, 464, 208, 509, and 191. 2. See Cunningham's "Anatomy" (1909), page 276; or Gray's "Anatomy''' (1908).. page 305. 3. See Cunningham's "Anatomy" (1909), page 401; or Gray's "Anatomy" (1908). page 383. 4. See Cunningham's "Anatomy" (1909), page 923; or Gray's "Anatomy" (1908). page 807. 5. See Cunningham's "Anatomy" (1909), page 1278; or Gray's "Anatomy" (1908), page 1457. 6. See Cunningham's "Anatomy" (1909), page 748; or Gray's "Anatomy" (1908),, page 1160. 7. See Cunningham's "Anatomy" (1909) page 864; or Gray's "Anatomy" (1908"). page 715. 8. See Cunningham's "Anatomy" (1909), page 647; or Gray's "Anatomy" (1908), pages 1026 and 1030. 9. See Cunningham's "Anatomy" (1909), pages 571, 531. 556, and 604; or Gray's "Anatomy" (1908),, pages 949, 905. 907, 925, and 946. 10. See Cunningham's "Anatomy" (1909), page 1213; or Gray's "Anatomy" (1908). page 1437. PHYSIOLOGY AND HISTOLOGY. 1. The retina is composed of several layers, from with- out inwards, as follows: (1) layer of pigment cells; (2) layer of rods and cones; (3) the external limiting mem- brane; (4) the outer nuclear, or granular, layer; (5) the outer molecular, or reticular, layer; (6) the inner nuclear, or granular, layer; (7) the inner molecular, or reticular, layer; (8) the layer of ganglion cells; (9) the layer of nerve fibers; and (10) the internal limiting membrane. These structures are bound together by sustentacular fibers or neuroglia. The portion concerned in most acute vision is the macula lutea, and especially its central portion, the fovea. The blind spot is that part of the retina at which the optic nerve enters ; it is occupied entirely by fibers of the optic nerve, and is devoid of any elements of the retina ; it is insensitive to light. 2. For histological structure, see above, Anatomy, 10. The function of the suprarenal bodies is not defi- nitely settled : they produce an internal secretion which is 707 MEDICAL RECORD. probably necessary to life, which is also said to increase the blood pressure by a vasomotor action on the arterioles ; some tonic action on the cardiac muscle is also attributed to them; and it is supposed that they are able to destroy or remove some toxic substances. 3. For development of lungs, see Cunningham's "An- atomy" (1909), page 992. Residual air is the air which still remains in the lungs after the deepest expirations. It measures about 100 cubic inches. Vital capacity is the amount of air which can be expelled from the lungs by an extraordinary expiration after the most forcible inspiration. It includes the tidal, comple- mental, and reserve air, and measures about 225 to 230 cubic inches. 4. During contraction the following changes take place in a muscle: (1) It becomes shorter and thicker, but the volume re- mains the same. (2) It consumes oxygen. (3) It sets free carbon dioxide. (4) It forms sarcolactic acid. (5) It becomes acid in reaction. (6) It becomes more extensible and less elastic. (7) There is an increase in heat production, and conse- quently a rise of temperature. (8) The electrical reaction becomes relatively negative. 5. The normal arterial blood pressure varies ; the systolic pressure being about 120 to 150 mm. of mercury, and the diastolic from about 90 to 120 mm. of mercury. Blood pressure is maintained by the contraction of the heart, the peripheral resistance, and the elasticity of the arterial walls. Blood pressure : May be raised- 1. By the heart beating more quickly. 2. By the heart beating more powerfully. 3. By contraction of the ar- terioles. May be. lowered- 1. By the heart beating more slowly. 2. By the heart beating more feebly. 3. By dilatation of the ar- terioles. 4. By deficient supply of blood to the left ven- tricle. 798 MEDICAL RECORD CHEMISTRY. i. The combining power of one atom of nitrogen is equal to three times that of an atom of hydrogen; or one atom of nitrogen can combine with or replace three atoms of hydrogen (or other univalent element). The atomicity of the oxygen molecule is two, because one molecule of oxygen (0 2 ) contains two atoms. The atomicity of the ozone molecule is three, because one molecule of ozone (O3) contains three atoms. 2. The equation is P 4 + 10 Cl 2 = 4 P CU. (4X31) grams P require (10X22.4) liters CI. 124 grams P require 224 liters CI, at normal tempera- ture and pressure. 224 . • . 1 gram P requires liters CI, at normal T 124 and P, but at 15 C. and 780 mm. pressure S224 273 + 15 760 \ 1 gram P will require I X X 1 V124 273 780/ liters CI. 24 273 780 224 288 760 68096 = X X— — — — — =1.85 .. LITERS OF 124 273 780 36673 CHLORINE. 3. Sodium is a silver- white metal, is waxy at ordinary temperature, becomes quickly tarnished, and coated with a yellow film in air. It oxidizes in air ; it burns with a yellow flame ; it decomposes water with evolution of hy- drogen. It is univalent, and has atomic weight of 23. Silver is a white metal, soft, malleable, and ductile ; is not acted on by pure air, but is blackened in air containing H 2 S. It makes an alloy with many metals. It is an ex- cellent conductor of heat and electricity. It is univalent, and has atomic weight of 107. Sodium belongs to the group of alkali metals (Li., Na., K., Ce.) ; because the properties of these elements are similar. Silver resembles the members of the same group in chemical properties, and therefore might be placed with them ; but its physical properties are more like those of copper, or gold, or mercury, and it has been classed by various writers with each of these metals. 4. Paraffin is a name given to the members of the meth- ane series of organic compounds. They are saturated hydrocarbons, and have the general algebraic formula Cfi Hsn + 2. 799 MEDICAL RECORD. ACIDS IN THIS SERIES. 1. Formic acid. 2. Acetic acid. 3. Propionic acid. FORMULA. H, COOH. CH 3 , COOH. CH 3 , CH 2 , COOH. ( PERCENTAGE IMPOSITION. c H 26.08 40.00 48.64 4-34 6.66 8.1 1 69.56 53.33 43.23 5. An amine is a substance derivable from ammonia by the substitution of a hydrocarbon radical for part or all of the hydrogen. Example : — H\ CH 3 \ H-N H-N H/ H/ Ammonia. Methylamine. An amide is a substance derivable from ammonia by the substitution of an oxidized radical for part or all of the hydrogen. Example : — H\ C 2 H 3 0\ H— N H— N H/ Hy Ammonia. Acetamide. An imide is a compound derived from a dicarboxylic acid by the substitution of NH for 2 OH. Example : — COOH CO\ I I NH COOH CO/ Oxalic acid. Oximide. 6. Bluestone. Red precipitate. White vitriol. Aqua fortis. Mirbane. Guncotton. Cresol. Urea. NAME. Cupric sulphate. Mercuric oxide. Zinc sulphate. Nitric acid. Nitrobenzene. Hexanitrocellulose Methyl phenol. Carbamide. CHEMICAL FORMULA CuSO* HgO ZnSO* HNOa C 6 H 5 N0 2 C 12 H 14 (ON0 2 ) e 4 GH^OH.CH* CON 2 H 4 800 MEDICAL RECORD 7- ACID. Acetic. Oxalic. Lactic. Tartaric. SERIES, WITH GENERAL FORMULA OF SERIES. CnH2n02 CnH2n-2U4 Paraffin monocarboxylic acids Paraffin dicarboxylic acids. Oxyacetic acids. CnH 2 «0 Dioxydicarboxylic acids. CwHjjn^Oo 8. "For the determination of total nitrogen 5 c.c. of urine are placed in a long-necked Kjeldahl digesting flask along with 0.5 gm. of CuSO* and 15 c.c. of concentrated H2SO4. The flask is supported at 45 ° to the horizontal and gradu- ally heated until white fumes are given off; 10 gm. of K2SO4 are then added, and the contents of the flask heated just short of boiling until almost colorless. After cooling, the contents of the digesting flask are transferred and washed into a distilling flask; the acid is nearly neutral- ized by the slow addition of NaHO solution (sp. gr. 1.24) ; a few pieces of granulated zinc are added, and then a moderate excess of NaHO solution, whereupon the flask is immediately connected with a bulb tube and condenser, so arranged as to deliver the distillate into a recipient con- taining 30 c.c. of N/5 H2SO4 and a little lacmoid as an in- dicator. The distillation is continued until about two-thirds of the liquid have passed over, when the excess of H2SO4 remaining in the recipient is determined by titration with N/5 NaHO solution. Each c.c. of N/5 acid neutralized by the ammonia formed in the process corresponds to 0.0028 gm. of nitrogen in the 5 c.c. of urine used. A blank proc- ess must be conducted with reagents alone to guard against error from nitrogen compounds in the reagents or in the air." (Witthaus's Manual of Chemistry.) To estimate the amount of nitrogen in 10 c.c. of urine, multiply this result by two. MATERIA MEDICA AND PHARMACOLOGY. i. (a) A normal salt solution can be made by adding V/z drams of sodium chloride to one quart of sterile water. (b) A one to two thousand bichloride of mercury solu- tion can be made by adding 7% grains of mercury bichlo- ride to a liter of water. (c) A 2.V2 per cent, solution of carbolic acid can be made by adding 6 drams of carbolic acid to a liter of water. (d) Lime water is a saturated solution of lime. It is made by washing slaked lime and shaking it up in distilled water, using about one grain of lime to each ounce of water. After it settles the water is poured off from the sediment and strained. 801 MEDICAL RECORD. (e) A nutrient enema can be made with 8 ounces of milk, three eggs, and half a dram of salt. 2. Styptic is an agent which, on being applied locally, stops bleeding. Example :-— Silver nitrate. Specific is an agent which has a distinctly curative effect on a particular disease. Example :— -Quinine, in malaria. Collyrium is an eye wash. Example: — Boric acid in dis- tilled water (gr. j, or ij to Jj). Alkaloid is a basic nitrogenous substance of alkaline re- action, and capable of combining with acids to form salts in the same way that ammonia does. Example :— Morphine. Alterative is an agent which modifies the course of a disease for the better ; its action is not determined, but probably it promotes waste and favorably modifies nutri- tion. Example : — Arsenic. 3. Morphine is the best where pain is present ; it acts quickly, but it is most apt to cause a habit formation, and therefore should not be used unless necessary. Chloral hydrate produces a natural sleep, acts promptly, but is of no service if pain is present; it also lowers the body temperature. It can be given for a long time with- out deleterious effect, but it may irritate the tissues and weaken the heart. Sulphonal produces a natural sleep, but is of slow action, requiring 3 or 4 hours to take effect ; it is of no use if pain is present, does not irritate the tissues and weaken the heart, but is probably not so good for continuous use as chloral hydrate, though the two may replace each other for a time. "The antagonism between morphine and atropine is in part real, such as their respective effects on the convolu- tions, respiratory center and intestines. In part it is appar- ent only. Thus, the contraction of the pupil caused by morphine occurs through the pupillary center ; the dilatation caused by atropine is referable to paralysis of the ciliary branches of the third nerve. Morphine is diaphoretic through the centers ; atropine is anhydrotic through the terminal nerves of the glands. Both depress the Ireart and reduce blood pressure in poisonous doses. Thus morphine and atropine are not true antagonists, but the one may prevent or relieve certain effects of the other, and may therefore be (1) combined with the other for particular medicinal purposes, or (2) given in the treatment of pois- oning by the other under particular circumstances. " (J. Mitchell Bruce, Materia Medica and Therapeutics.) 4. Glycerini pepsini 3J. Tincture nucis vomicae. Acidi hydrochlorici diluti aa 1T£xl. Aquae destillatae q.s. ad ^iv. Misce. Signa : — One tablespoonful three times a day., 802 MEDICAL RECORD Phenol. Acetanilidum. Xitroglycerinum. ORDINARY, OR OTHER NAME. belie acid. Antifebrin. Glonoin. DOSE. Hydrargyri sub- i Calomel. chloridum. Pulvis ipecacuanhae . : . s • >wder. compositus. I to 3 grains. ! I to 3 gra:: i drop of a solution. : 2 to 5 grains. i- 5 to 15 grains. Phenol is an ant: and disinfectant Ace : is an antipyretic. Xitroglycerinum dil: e blood ves : and lowers arterial tension. Calomel is a purgative. Do* Powder is a diaphoretic, and less lex irritation. 6. .: ate is given internally in pill form, in dose- gr. 1/5. gr, iv, in syi Tincture of chloride of iron, dose HJJvij in glycerin. Folder's Solution, dose flgiij, in water, after meals. Potassium iodide, dose gr. vij, in Compound Syrup rilla. THEORY AND PRACTICE OF MEDICINE. i. See French's "Pract Medicine" (1907). page - : or 0- Practice of Medicine" (1909), page £86. 2. Flinfs murmu :lic murmur heard at the x of the heart in some cases of aortic regurgitation. sed to be due to the vibration of the anterior ] of the mitral valve, as it lies between the regurgitat- ing blood stream and that which is flowing into the left ventricle from the left auricle. It is to be distinguished from mitral stenosis. This is best done t tidy of the pulse, which is very different c two conditions. 3. See French's "Practice oi Medicine" ) . page S Osier's "Practice of Medi page 683. 4. See French's "Practice oi Medicine" (1907). page 8 or Osier's "Practice of Medicine*' . page 534. 5. See French's "Practice of Me W), page & or Os'er's "Practice of Medicine'' (1909), page ( PATHOL 1. See Rose and Carless* ''Surgery" (1908), page 1234: or Da Costa's "Surgery" (1908), page 1172. 2. Benign tumors are encapsulated, do not tend to in- filtrate the surrounding tissues, do not give rise to metas- 803 MEDICAL RECORD. tatic growths, do not tend to recur after removal, do not produce cachexia, and do not have a fatal tendency (ex- cept from their location). Malignant tumors are not encapsulated, tend to infiltrate the surrounding tissues, give rise to metastatic growths, have a tendency to recur after removal, give a cachexia, have a fatal tendency. Adenoma: See Rose and Carless' "Surgery'' (1908), page 208; or Da Costa's "Surgery" (1908), page 328. Glioma is usually single, but may be multiple, is soft, gelatinous, grayish or pink, according to the number of blood-vessels in it, the outline is not distinct. Microscop- ically, it contains glia cells, with a small amount of proto- plasm, but large, round or oval nuclei, and many thin fibrils which interlace with each other. 3. See Rose and Carless' "Surgery" (1908), pages 589, 593, and 580. 4. See Williams' "Obstetrics" (1909), page 852; or Hirst's "Obstetrics" (1909), page 715. BACTERIOLOGY. 1. "Active immunity follows an attack of a certain dis- ease and secures immunity for that alone, which may last but a short time (erysipelas, cholera) or for a longer period (typhoid), or even for life (variola) ; or it follows inoculation of a virus weaker than necessary to cause the typical disease (vaccination against smallpox) ; or it fol- lows inoculation by bacterial products apart from the organisms themselves. "Passive immunity is the term applied to the effect of a serum derived from an immunized animal and injected into one not immune, the theory being that in the blood of the former there is a chemical substance (antitoxin) which neutralizes the toxin in the donating animal, or otherwise it would show symptoms, and by borrowing its serum for the infected animal the toxin is opposed by the alien antitoxin."-— (From Thayer's Pathology.) 2. Bacillus anthracis. Morphology: It is a large, rod- shaped microorganism, with slightly thickened ends; it is from 5 to 20 mikrons in length, and a little more than one mikron in breadth ; it has a tendency to form long threads ; it is nonmotile and nonflagellated ; it is aerobic. Staining : — It stains by all the alkaline aniline dyes, and also by Gram's method. Cultural characters: — It grows on practically all media, as a film on potato, in tree form in gelatin stab, it lique- fies gelatin and also serum. Pathogenicity: — It causes anthrax, splenic fever, malig- nant pustule, and wo'olsorter's disease. Infection takes 804 [MEDICAL R1XORD place through wounds, or by the respiratory or alimentary tract. The bacilli are probably destroyed by the gastric juices, but not so the spores. THERAPEUTICS. 1. See French's "Practice of Medicine" (1907), page 230; or Osier's "Practice of Medicine"' (1909), page 226. 2. Therapeutic uses of ergot: Ergot stimulates and causes contraction of involuntary muscle libers, hence it is a vaso- constrictor, hemostatic, and oxytocic. It is also a cardiac sedative, it raises the blood pressure, it increases peristal- sis, and is an emmenagogue. Indications: To promote uterine contractions during third stage of labor; iibroids, menorrhagia, post-partum hemor- rhage. Some forms of amenorrhea and dysmenorrhea, dysentery, arterial hemorrhage, congestive headaches, laxity of sphincters, of bladder or rectum, hemorrhoids, aneurysm, diabetes, urinary incontinence, direct paralysis of the sphincter vesicae, atonic spermatorrhea. "While the efficacy of ergot in certain forms of metor- rhagia has been conclusively proved, there is no satisfactory evidence that the drug is of value in other forms of hem- orrhage, such as hemoptysis, hematuria, or hematemesis. On the contrary, our knowledge of its physiologic action in- dicates that it may be productive of harm. Granting that ergot can lessen the caliber of eroded, degenerated, or se- riously wounded vessels, there is no reason for supposing that its influence is restricted to the vessels concerned in the bleeding, and if such is not the case, the universal con- striction of the arterioles induced by the drug, and the consequent rise in the general blood pressure must favor the escape of blood from the injured vessels and militate against the formation of an occluding thrombus."— (Steven's Materia Medical 3. See French's "Practice of Medicine" (1907), page 621; or Osier's "Practice of Medicine" (1909 V page 842. 4. See French's "Practice of Medicine" I 1007), page 400. MIDWIFERY, OPERATIVE. I. (a) The occiput is depressed and posterior, and points to the right sacroiliac synchondrosis ; the smaller fonta- nels is in the same locality. The sagittal suture runs obliquely forward and to the left, in the line of the right oblique pelvic diameter. The shoulders lie at right angles to this, in the left oblique pelvic diameter. The anterior fontanelle may be felt anteriorly, high up and to the left. (b) The case may end: (1) By anterior rotation of the" occiput, (2) the occiput may remain posteriorly in the hollow of the sacrum; (3) a face presentation may result; 80; iMEDICAL RECORD. (4) the labor may become arrested, or uterine inertia may ensue. (c) (1) Manual rotation and extraction by forceps may be tried; or (2) forceps, rotation, and extraction; or (3) forceps extraction, with the occiput remaining posterior. 2. See Williams' "Obstetrics" (1909), pages 285 and 290; or Hirst's "Obstetrics" (1909), pages 419 and 425. 3. See Williams' "Obstetrics" (1909), page 438; or Hirst's "Obstetrics" (1909), page 830. 4. The differential points between placenta prsevia and premature separation of a normally attached placenta are shown in the following table (from Dorland's Obstetrics) : PLACENTA PREVIA. Most commonly manifests itself after the sixth month of gestation, but may occur as early as the second month. The hemorrhage is abrupt, but painless. There are generally repeat- ed hemorrhages of in- creasing severity. There is an edematous con- dition of the cervix and lower uterine segment, with marked pulsation. Cervix is generally quite patulous, and within may be detected the placenta. The placental bruit is situ- ated low down. PREMATURE DETACHMENT. Most commonly occurs dur- ing the first stage of la- bor, but may occur at any time during the last three months of pregnancy. The hemorrhage is sudden, and generally is attended with sharp pain. Hemorrhage persists until the uterine contents are evacuated or the patient perishes. Vaginal examination re- veals no deviation from the condition normal to pregnancy. The cervix is perhaps (if labor be initiated) slight- ly patulous. The placental bruit is in normal position. MIDWIFERY OTHER THAN OPERATIVE, AND PUERPERAL DISEASES. I. The diseases of the mother liable to injure the fetus in uter are: Malaria, relapsing fever, typhoid, typhus, yellow fever, scarlet fever, measles, smallpox, cholera, pneumonia, cardiac disease with inadequate compensation, exophthalmic goiter, hepatic disease and jaundice, toxe- mia, eclampsia, diabetes, and pernicious anemia. The causes of labor at full term are not definitely known. Among the theories held, or factors supposed to be in- volved, are the following: (1) The gradual distention of the uterus at the end of pregnancy, after it has reached the physiological limit of its growth, while the contents still 806 MEDICAL RECORD. continue to grow; (2) the fetus becomes a "foreign body/' and as such excites uterine contractions and is extruded; (3) fatty degeneration of the placenta and of the decidua; (4) the circulation of toxic products in the placental blood acts upon a center in the medulla and so produces labor. 2. See Williams' "Obstetrics" (1909), pages 818 and 821 ; or Hirst's ''Obstetrics" (1909), page 585. 3. See Williams' "Obstetrics" (1909), page 541; or Hirst's "Obstetrics''' (19x9). page 635. 4. Treatment of infantile colic: ''The following formulas will in most cases give relief: IJ. Lime-water. Comp. tincture of cardamom, each. Ji. Give a teaspoon ful every half hour. R. Spirits of chloroform gtt. 16 Aromatic spirits of ammonia 5 1 /? Sodium bicarbonate gr. 16 Syrup - IV 2 Peppermint water q.s. §2 One teaspoonful, as necessary, for pain. "In many cases the most efficient method of relieving the pain is an enema of j^d of warm water and sodium bicarbonate 3j^. A few r drops of gin in warm water may be given by the mouth. Hot applications should be made to the abdomen, and if symptoms of collapse appear, a hot bath should be given." — (Gould and Pyle's Pocket Cyclo- pedia.) 5. (a) In a breech presentaation the discharge of me- conium has no significance. (M In a vertex presentation it is a danger signal, and implies a compressed cord, or fetal apoplexy, and delivery should be hastened. SURGERY, OPERATIVE. i. See Rose and Carless' "Surgery" (1908), page 956; or Da Costa's "burgery" (1908). page 1236. 2. Excision of the elbow is performed for : Chronic joint disease (generally tuberculosis); wounds; faulty ankylosis, or other deformity; disease of the articular ends of the bones : fracture dislocation ; compound com- minuted fracture. See Rose and Carless' "Surgery'' (1908'), page 692; or Da Costa's "Surgery" (1908), page 625. 3. See Rose and Carless' "Surgery" (1908K page 1161; or Da Costa's "Surgery" (1908), page 1105. 4. See Rose and Carless' "Surgery" (1908), pages 928. 929, 983. and 1055: or Da Costa's "Surgery" (1908), pages 786. 784, and 632. 5.- See Rose and Carless' "Surgery" (1908), pages 1229 and 1230; or Da Costa's "Surgery" (1908V page T190. S07 MEDICAL RECORD. 6. See Rose and Carless' "Surgery" (1908), pages 1024, 1027, and 1029; or Da Costa's "Surgery" (1908), page 963. SURGERY OTHER THAN OPERATIVE. i. See Rose and Carless' "Surgery" (1908), pages 83 and 86; or Da Costa's "Surgery" (1908), pages 195 and 198. 2. See Rose and Carless' "Surgery" (1908), page 124; or Da Costa's "Surgery" (1908), page 204. 3. See Rose and Carless' "Surgery" (1908), page 570; or Da Costa's "Surgery" (1908), page 440. 4. See Rose and Carless' "Surgery" (1908), pages 306, 313, and 2> 2 7\ or Da Costa's "Surgery" (1908), pages 356 and 364. 5. oee Rose and Carless' "Surgery" (1908), pages 482, 507, and 521; or Da Costa's "Surgery" (1908), pages 497 and 506. 6. See Rose and Carless' "Surgery" (1908), pages 1223 and 1227; or Da Costa's "Surgery" (1908), pages 1185 and 1 187. MEDICAL AND SURGICAL ANATOMY. 1. (a) The middle meningeal artery crosses the anterior inferior angle of the parietal bone at a point i*A inches behind the external angular process of the frontal bone, and the same distance above the zygoma. From this point the anterior branch passes upward and somewhat back- ward toward the sagittal suture, lying a little over half an inch behind the coronal suture. The posterior branch passes upward and backward over the squamous portion of the temporal bone. (b) To locate the fissure of Rolando on the scalp : Draw a straight line over the top of the scalp from the inion to the glabella; bisect this line, and half an inch posterior to the midpoint draw a line downward and forward at an angle of 67.5 for a distance of s J A inches. This line will represent the location of the fissure of Rolando. (c) The course of the lateral sinus is represented by a line drawn from the external occipital protuberance to the base of the mastoid process, and another line from the base of the mastoid to its tip. 2. The refiex center for the bladder, in the lumbar en- largement of the spinal cord; for the rectum, in the lumbar enlargement of the spinal cord; for ankleclonus, in the anterior horns of the third to fifth sacral segment of the spinal cord; for knee jerk, in the anterior horns of the second to fourth lumbar segments of the spinal cord; for wi'ist jerk, in the anterior horns of the sixth to eighth cervical segment of the spinal cord; for elbow jerk, in the anterior horns of the sixth cervical segment of the spinal cord. 808 MEDICAL RECORD. 3. The parts entering into the formation of the wrist joints are: The lower end of the radius, the under surface of the interarticular fibrocartilage, and the scaphoid semi- lunar and cuneiform bones; cartilage, anterior, posterior, external lateral, and internal lateral ligaments, and syno- vial membrane. 4. Colles's fracture is a fracture of the lower end of the radius; it is generally transverse, and is usually within an inch or an inch and a half of the articular surface. There is a characteristic deformity caused by the lower fragment, and the carpus forming a prominence on the dorsal sur- face; at the same time there is a projection on the palmar surface just above the wrist, caused by the upper frag- ment. The hand is abducted and pronated, and the styloid process of the ulna becomes very prominent. Pott's fracture consists of a fracture of the lower end of the fibula, about three inches above the tip of the malle- olus; and a fracture of the internal malleolus. The foot is twisted outward, the sole everted, and the heel drawn up; there is a depression at the site of the fracture, the inner malleolus either projects prominently or the frag- ment can be felt and crepitus elicited ; the foot is shortened and the ankle is swollen and widened. 5. By a digital examination of the rectum there can be made out : The external sphincter, the internal sphincter, the rectal insertion of the levatores ani, the anal canal, the condition of the ischiorectal fossae, the coccyx, hollow of sacrum, lower part of sacrum, tuberosity of ischium, wall of pelvis, great sacrosciatic ligament. In addition, in the male: The membranous urethra, the prostate, vasa defer- entia, seminal vesicles, distended bladder. In the /v-male: Perineal body, rectovaginal septum, os uteri, cervix uteri, ovaries. 6. See Cunningham's "Anatomy'' (1909), page 1182; or Gray's "Anatomy" (1908), page 1498. 7. The parts cut through in amputation at the upper third of the leg are : Skin ; fascia ; bones, tibia, and fibula ; interosseous membrane; muscles, tibialis anticus, tibialis posticus, extensor longus digitorum, extensor proprius hallucis, flexor longus hallucis, flexor longus digitorum, peroneus longus, peroneus brevis, soleus, gastrocnemius, and the tendon of the plantaris ; arteries, anterior tibial, posterior tibial, peroneal; veins, the venae comites of the arteries, external saphenous, internal saphenous ; nerves, anterior tibial, posterior tibial, external saphenous, com- municans peronei, musculocutaneous. The main vessels tied are: The anterior tibial, in front of the interosseous membrane ; the posterior tibial, be- neath the deep transverse fascia and behind the tibia ; the 800. MEDICAL RECORD peroneal, beneath the deep transverse fascia and behind the fibula. 8. In the right inguinal region may be found: Ovarian tumors, pelvic abscesses, diseases of the cecum and ap- pendix, fecal impaction, hernia. In the left inguinal region may be found: Tumor of the sigmoid, ovarian tumors, pelvic abscesses, volvulus, fecal impaction, hernia. In the hypogastric region may be found: Distended bladder, uterine tumors and cysts, pregnant uterus. 9. Scarpa's triangle is a triangular area or depression situated just below the fold of the groin. It is bounded above by Poupart's ligament, externally by the Sartorius. and internally by the inner margin of the Adductor longus ; its apex is formed by the junction of the Adductor longus and Sartorius. The -floor is formed, from without inward, by the Iliacus, Psoas, Pectineus, Adductor brevis, and Adductor longus. Contents : The femoral vessels pass from about the center of the base to the apex, the artery being on the outer side of the vein ; the artery gives off the su- perficial and profunda branches, and the vein receives the deep femoral and internal saphenous; the anterior crural nerve lies to the outer side of the femoral artery; the ex- ternal cutaneous nerve is still further external, lying in the outer corner of the space; just to the outer side of the femoral artery, and in the sheath with it, is the crural branch of the genitocrural nerve. At the apex, the vein (which at the base was internal to the artery) lies behind the artery. The triangle also contains fat and lymphatics. Its surgical importance is due to the number of important structures which it contains (see above). Its apex is the point for ligating the femoral artery; digital pressure, or ligation, is applied here in case of popliteal aneurysm; femoral hernia appears in the upper part, and psoas abscess often points here, too. 10. The collateral circulation after ligature of the fem- oral artery in Hunter's canal: (1) The external circum- flex; with the lower muscular branches of the femoral, anastomotica magna, superior articular of the popliteal, and anterior tibial recurrent. (2) The perforating and terminating branches of the profunda ; with muscular branches of the femoral, and muscular and superior artic- ular branches of the popliteal. (3) The comes nervi ischia- dici ; with the perforating branches of the profunda, and the articular branch of the popliteal. MEDICAL JURISPRUDENCE. 1. Avoid injuring the pericardium or other intrathoracic tissues. 2. The presence or absence of dilatation or aneurysm. 8to MEDICAL RECORD 3. "Grasp the heart by the base and turn it up to expose the posterior surface, estimate by the eye a line midway between the anterior and posterior coronary arteries and along this cut into the left ventricle from the base to the apex with one long sweep of the knife; open the right ventricle by a similar cut midway between the posterior coronary and the right (really the inferior) margin of the heart, the space being usually quite free from fat; as the left ventricle is opened insert the index finger of the left hand, put the thumb into the other cut — between the two is the septum — and with that hold the heart is easily managed in the further cutting; avoid pressing the septum between thumb and finger. Lift the organ straight up and cut the stretched vena cava inferior as long as possible just as it enters the pericardium ; swing the heart to the right side and cut the pulmonary veins on the other, reverse and the remaining pulmonary veins and superior cava; only the aorta holds it now and that is cut from below upward he heart is lifted and carried toward the chin; if the knife is sharp and clean long cuts are made, two or three are enough and there is no spattering of blood." — (Thay- er's Pathology.) 4. Death by suffocation is due to asphyxia ; that is, air cannot get to the blood, and eventually the respiratory center becomes paralyzed by the prolonged action of the increasingly venous blood. 5. The average weight in an adult of the brain is : male, 4972 ounces ; female, 44 ounces. Heart, male, 10 to t2 ounces: female, 8 to 10 ounces. Spleen, about 7 ounces. Liver, male, 50 to 60 ounces; female, 40 to 50 ounces. Kidney, male, 472 to 6 ounces; female, 4 to s T 4 ounces. TOXICOLOGY AND MENTAL DISEASES. 6. Cocaine Poisoning. (a) Symptoms: "When^ a large dose has been taken the symptoms are not unlike those of atropine poisoning. There is dryness of the throat, tongue, and nose, difficulty of swallowing, faintness, and sometimes nausea and vomiting. The pulse is usually in- creased in fullness and frequency at first. The respiration also becomes more rapid, and there is much general ner- vous excitement, with general hyperesthesia. The eyes are bright and staring and the pupils dilated. The patient talks volubly and incoherently. Sometimes an erythema- tous eruption appears on the skin. The stage of depression soon comes on, when the breathing becomes shallow, the heart's action more rapid, and the face pale or cyanotic. The_ surface becomes anesthetic, and muscular twitchings and" paralysis precede death, which is generally caused by paralysis of respiration." 81 1 MEDICAL RECORD. (b) Period when fatal: — Less than one hour. If the patient survive half an hour the prognosis is good. (c) Fatal quantity: — 15 yi grains. The smallest fatal dose on record is 1.2 grain for an adult. Twelve drops of a 4 per cent, solution hypodermically caused the death of a girl eleven years of age in 40 seconds. Twenty-two grains by the mouth and 10 grains hypodermically have been re- covered from.— (Riley's Toxicology.) 7. The special indications of mental -weakness are :- — Lack of attention, inability to concentrate the mind on one's work, loss of memory, incoherence, personal untidi- ness and neglect, hallucinations and illusions, lack of de- cision and will power, irritability of temper and disposi- tion, insomnia. 8. In opium poisoning the pupils are contracted, respira- tion is slow, pulse slow and full, body temperature is normal or subnormal, there may be the odor of laudanum on the breath. In acute alcoholism the patient can generally be aroused ; the coma is not, as a rule, complete; the face may be flushed ; the pupils are normal or dilated ; the respirations are normal in frequency, but deep; the skin is cool and moist, and the body temperature may be below normal; there may be the odor of alcohol on the breath. In epilepsy there will be a brief aura, sudden and com- plete loss of consciousness, pupils dilated and rigid, the tongue will be bitten (unless prevented), the sphincters may be relaxed, there may be a slight rise of temperature. In cerebral hemorrhage :— There are generally paralysis of the head and upper limbs ; and in left-sided lesions there may be aphasia; the pulse is slow and full; the respirations are at first slow, regular, and stertorous, later on becoming of the Cheyne-Stokes type. SANITARY SCIENCE. i. (a) Of the rain that falls: — Part is evaporated; part flows off in streams and rivers; part sinks into the earth through cracks and fissures and flows toward some water channel or the sea; and part comes back to the surface again in the form of springs. (b) The objections to using rain water as it falls are: — The rain takes up gases from the air (chiefly oxygen, nitrogen, and carbon dioxide), but also ammonia, nitrous and nitric acids ; also suspended matters which may be floating in the air, such as soot. In this way impurities may be present to the extent of 2^2 grains per gallon of water. 2. (a) The sources of water supply are: Rain and snow; (2) surface waters (rivers, lakes, and ponds); (3) 812 MEDICAL RECORD. subsoil or ground water; (4) deep waters (spring and artesian well). (b) Three methods of purifying water :— Distillation, filtration, and boiling. (c) Water stored in cisterns may become foul, it is stag- nant, it absorbs impurities from the air, lead may be ab- sorbed^ and sewer gases or coal gases or filth may be drawn into the water. (d) "A cistern should be placed at the top of the house, and fed by a supply-pipe controlled by a ball-cock. It must be large enough to contain at least a day's supply and must not directly supply the water-closet. It may be made of lead, lined with pitch or other protective coating, or of galvanized iron, or of slate slabs set in cement. It should be effectually covered, but ventilated, and provided with an overflow discharging into the open air away from any source of effluvia. Frequent inspection and cleansing are necessary." — (Whittegge and Newman's Hygiene.) 3. Diseases caused by the use of impure water are :— Typhoid, cholera, dysentery, diarrhea, goitre, intestinal parasites, metallic poisoning, vesical calculi. 4. Inspection of sewers means a thorough testing of drains, pipes, and sewers. Flushing is regular and thorough washing out. Ventilation is a provision for the admission and discharge of air, to prevent pressure of air or gas being exercised upon the house-traps. 5. In Cameron's septic tank system "the sewage is first led into a tank from which air and light are excluded. Di- gestive changes take place in the sewage within this tank as the result of anaerobic bacterial action, which is favored by the darkness, the absence of air, and the perfect stillness at which the sewage is maintained. Under these circum- stances much of the solid matter is rendered soluble and dissolved." — (Xotter and Firth's Hygiene.) 6. Air is vitiated by : — The respiration of men and ani- mals ; the products of combustion and artificial lighting; substances yielded by factories, workshops, mines, sewers, marshes, cemeteries, etc.; organic products given off by human beings. 7. The advantages of a mountain climate, as contrasted with plains, are: — (1) Greater movement of air, strong winds; (2) less humidity; (3) more sunlight; (4) less suspended mattter in the air; (5) a lower temperature. THERAPEUTICS. 1. Belladonna is used: "Locally, to relieve pain of all kinds ; to relax spasm ; to promote the resolution of en- larged glands; to check sweating, suppuration, and the se- cretion of milk; atropine is used extensively in ophthal- MEDICAL RECORD. mological practice. Internally, to check mercurial and other ptyalism; night-sweats of phthisis and other abnor- mal perspirations; serous diarrhea; intestinal, hepatic, and renal colic; to prevent the griping of purgatives; with opium in appendicitis or peritonitis; painful gastric affec- tions; vomiting; sick-headache due to or accompanied by spasm of the arterioles; cardiac disease; shock and col- lapse; caseous pneumonia; acute coryza; whooping-cough and other spasmodic affections of the respiratory passages ; mastitis ; incontinence of urine ; seminal emissions ; vesical spasm; chordee, erysipelas; scarlatina when the rash is imperfectlv developed; the low, muttering delirium of typhoid and typhus fevers ; certain forms of delirium tre- mens; sciatica and neuralgia; epilepsy. In many conditions atropine is most advantageously administered by hypoder- matic injection and belladonna by suppository. The smoke of belladonna leaves is inhaled for asthmatic attacks." — ('Wilcox's Materia Medica.) Symptoms of poisoning by belladonna: "In the rirst stage, that of delirium, there are dryness of the throat, thirst, difficulty of deglutition and spasms upon swallowing liquids, face at first pale, afterwards highly reddened, pulse ex- tremely rapid, eyes prominent, brilliant, with widely dilated pupils, complete paralysis of accommodation, disturbances of vision, attacks of giddiness and vertigo, with severe headache, followed by delirium, occasionally silent or mut- tering, but usually violent, noisy, and destructive, accom- panied by the most fantastic delusions and hallucinations. Usually the urine is retained, and the body temperature is above the normal. The delirium gradually subsides, and the second stage, that of coma, is established, with slow, stertorous respiration, and gradually failing pulse, until death occurs from respiratory or cardiac paralysis, or some- times in an attack of syncope during apparent ameliora- tion. "Treatment: Lavage of the stomach; morphine may be given cautiously during the period of violent excitement. Maintain respiration ; strong coffee by the mouth or rec- tum is beneficial. Pilocarpine may be given, in not too large doses, to stimulate the secretion of saliva." — (From Witt- haus' Essentials of Chemistry.) 2. See French's "Practice of Medicine" (1907), page 873 3. See French's "Practice of Medicine" (1907), page 594. 4. (a) For pleurisy with effusion: ]J. Emplastri capsici 2x2 inches Signa : Apply as directed. (b) For suppression of urine: R. i Triturationis* elaterini . .gr. ss Signa : Take at once. 814 MEDICAL KhCuKl) (c) For sciatica: I£. Linimenti chloroformi 3i y Signa : Rub in well, along the course of the sciatic nerve, every three hours. (d) For alkaline cystitis: R. Sodii benzoatis . . .5vj Aquae menthse piperita^ 311 j. M. Signa : L ake one teaspoonful in water every three hours. DISEASES OF WOMEN. 1. "The wound should be sutured at once and the urine which has escaped into the peritoneal cavity removed with a gauze sponge. Normal urine causes no irritation of the peritoneum, but if cystitis is present the urinary secre- tions are likely to produce infection and endanger the life of the patient. If the wound has been properly sutured there is no danger of subsequent leakage and drainage is therefore not indicated. It may be necessary if the tear is large to catheterize the patient every three or four hours for the first day after operation, and then every six hours for the next two days in order to avoid distention and undue strain upon the sutures. A permanent catheter should not be employed, as it is seldom indicated and may cause cystitis. Operation: A vesical tear involving only the outer coats of the bladder should be closed by a con- tinuous Lembert suture of No. 2 braided silk, which is carried upon a curved intestinal needle, and passed deep enough to include the torn structures. A deep tear in- volving all the coats and opening the cavity of the bladder should be closed by two tiers or layers of sutures as fol- lows : The first layer approximates the edges of the wound and the second tier reinforces and buries these sutures, thus guarding against the possibility of leakage. The approximation layer consists of a continuous suture of cumol catgut (No. 1), which is carried upon a curved intestinal needle and passed through all the coats of the bladder except the mucous membrane. The reinforcing tier consists of a continuous Lembert suture of No. 2 braided silk which is also carried upon a curved needle and passed through the peritoneum and the superncial por- tion ot the muscular coat of the bladder. — (Ashton s Gynecology.) 2. Pruritus vulvae may be caused by: Parasites; diseases of the vulva, as inflammation, edema, vegetations, conges- tion ; irritating discharges; lack of cleanliness ; diabetic urine : it may also be of nervous origin, or idiopathic. Treatment consists in removing the cause, if possible; cleanliness, fresh air, tonics, and general attention to hy- giene ; local applications of solution of bichloride of mer- 815 MEDICAL RECORD cury, i : 2,000; or carbolic acid, 1 : 100; or lead and opium; dusting powders of bismuth subnitrate, calomel, or zinc oxide are also useful. 3. "In the operation for complete laceration the rectovag- inal septum is split laterally, thus separating the vagina from the rectum for a short distance and thoroughly ex- posing the ends of the sphincter ani. The wound in the rectum is then closed by two layers of chromicized catgut sutures, one for the mucous membrane and a second for the outer coats. The sphincter ani is approximated by two or three additional catgut sutures. The operation is then completed as Emmet's, the lowest external suture being passed through the sphincter ani. Emmet's operation is as follows : "With the patient in the lithotomy position, guide su- tures or tenacula are passed through the apex of the reto- cele, and through each labium ma jus at the lowest carun- cula myrtiformis. By drawing on the lateral suture and pulling the central suture downward and to the opposite side, the lateral sulcus appears as a triangle with the apex up in the vagina. This triangle is denuded of mucous membrane by cutting off long strips by means of forceps and scissors, or by dissecting the mucous membrane off in one piece. The triangle on the opposite side is treated in the same manner, and the denudation completed by removing the mucous membrane between the bases of the triangles and below the central suture. Each lateral tri- angle is closed by interrupted sutures of chromicized cat- gut or silkworm gut, the latter being shotted. The needle, which should be curved, is entered near the margin of the wound on the outer side, passed deeply to catch the fibers of the levator ani, and brought out at the bottom of the sulcus, at a point nearer the operator; it is then reinserted at the bottom of the sulcus, and passed upwards and back- wards in the rectocele, to emerge opposite the point of the original insertion. The opposite triangle is treated in the same manner, which leaves a small raw area externally to be closed. The upper or "crown stitch" passes through the skin of the perineum below the lateral guide suture, then through the rectocele below the central guide suture, and finally through the tissues below the opposite guide stitch. As many sutures as may be necessary are inserted below this. If silkworm gut is used, the stitches should be removed on the tenth day. The external genitals are ir- rigated with weak bichlorid of mercury solution after each urination. Internal douches are not needed unless there be infection." — (Stewart's Surgery,) 4. In the retro displaced uterus, the fundus of the uterus is not found in its proper place, in the other conditions 816 MEDICAL RECORD the fundus would be against the bladder. In the ovarian cyst, vaginal examination (with the help of a sound) would show that the tumor was not connected with the uterus. In the case of a fibroid, there would probably be a uterine hemorrhage. 5. (a) Preliminary preparation includes all the usual antiseptic and aseptic precautions. (b) The uses of the uterine sound are: — (1) To dem- onstrate the mobility of the uterus; (2) to show the size of the uterus; (3) the presence of intrauterine growths; (4) deviations in the cervical canal, and (5) as an aid in the diagnosis of uterine displacements. (c) Contraindications: — (1) The least suspicion of even the possibility of pregnancy; (2) menstruation; (3) acute endometritis ; (4) malignant disease of the uterus or vagina; (5) acute pelvic inflammation. (d) Dangers:— (1) Abortion; (2) sepsis; (3) periton- itis; (4) hemorrhage; (5) perforation of the uterus. DISEASES OF CHILDREN. i. See French's 'Practice of Medicine" (1907), page 647; or Osier's ''Practice of Medicine" (1909), page 598. 2. Kernig's reflex (or sign) is present in meningitis or cerebrospinal fever in nearly every case. It is very rarely present in other conditions, hence it is a sign of much value. Babinski's reflex is said to indicate disease of the pyra- midal tract, except in children under two years of age, when the reflex is normal. Its absence does not prove that the pyramidal tracts are not diseased. There is still much uncertainty as to the value of this reflex, its chief value being in differentiating organic disease of the lateral col- umns from so-called "functional" conditions. In lobar pneumonia, if the toxic condition is very severe, the patellar reflex may be exaggerated. 3. See French's ''Practice of Medicine" (1907), page 572; or Osier's "Practice of Medicine" (1909), page 791. 4. Acute osteomyelitis, (a) The three most common infecting germs are : Staphylococcus pyogenes aureus, Staphylococcus pyogenes albus, and Streptococcus py- ogenes. (b) The three bones most frequently affected: Femur, tibia, and humerus (or radius). (c) Diseases for which it may be mistaken : Rheuma- tism, gonorrheal rheumatism, typhoid fever, tuberculous arthritis, cellulitis, and infantile scurvy. Treatment is immediate incision down through the peri- osteum ; the surface of the bone must be opened with gouge or chisel, pus evacuated, and drainage instituted ; irrigation 817 MEDICAL RECORD. with hot bichloride solution and packing with gauze. The medulla of the bone must be freely exposed, and any sup- purating material removed. Constitutional treatment and rest, are, of course, indicated. See Rose and Carless' "Surgery" (1908), pages 570. etc.; or Da Costa's "Surgery" (1908), pages 442 and 440. 5. The structures that would be pierced, are : Skin, sub- cutaneous fascia, epicranial aponeurosis, superficial tem- poral aponeurosis, deep temporal aponeurosis, temporal muscle, periosteum, squamous portion of temporal bone, dura, arachnoid, pia, and third temporal convolution of cerebrum. Symptoms and Treatment : See Rose and Carless' "Sur- gery" (1908), page 770; or Da Costa's "Surgery" (1908), page 712. REQUIREMENTS FOR MEDICAL LICENSURE In the following table the States requiring of the can- didate both a diploma from a recognized college and an examination are printed in roman; those requiring either diploma or an examination, in italics; those requiring an examination only, in small caps. State Fee State Fee Alabama $10 . 00 Nebraska $25 .00 Arizona 10 . 00 Nevada 25 . 00 Arkansas 10 . 00 New Hampshire 10 . 00 California 25 . 00 New Tersey 25 .00 Colorado 25 . 00 New Mexico 25 . 00 Connecticut 15 .00 New York. 25 .00 Delaware 10 . 00 North Carolina 10 . 00 District of Columbia. . . . 10 . 00 North Dakota 20 . 00 Florida 15.00 Ohio 25.00 Georgia 10 . 00 Oklahoma 5 . 00 Idaho 25.00 Oregon 10.00 Illinois 10 . 00 Pennsylvania 25 . 00 Indiana 25.00 Rhode Island 10.00 Iowa 10 . 00 South Carolina 10 . 00 Kansas 15. 00 South Dakota 20 . 00 Kentuckv 10 . 00 Tennessee 10 . 00 Louisiana 10.00 Texas 15 .00 Maine 10.00 Utah 15.00 Maryland 15.00 Vermont 1 5 . 00 Massachusetts 20.00 Virginia '. . 10.00 Michigan 25 . 00 Washington 25 . 00 Minnesota 10 . 00 West Virginia 10 . 00 Mississippi 10.00 Wisconsin 10.00 Missouri 15 . 00 Wyoming 25 . 00 Montana 25.00 BULLETIN OF APPROACHING EXAMINATIONS! state name and address of place and date of secretary next examination Alabama* W. H. Sanders, Montgomery. .Montgomery. . .Jan. Arizona* Ancil Martin, Phoenix Phoenix Oct. 3 Arkansas F. T. Murphy, Brinkley Little Rock Nov. 8 California* Chas. L. Tisdale, 929 Butler Building. San Francisco Los Angeles.. . .Dec. 6 818 MEDICAL RECORD. STATE NAME AND ADDRESS OF PLACE AND DATE OF SECRETARY NEXT EXAMINATION rado S. D. Van Meter. 1723 Tremont Street. Denver Denver Oct. 4 necfcieut*....Chas. A. Tuttle. New Haven. . .New Haven. . . .Nov. 14 Delaware J. H. Wilson, Dover Dover Dec. 13 of Col'bia . Geo. C. Ober. Washington Washington. . . . Oct. 1 1 ia* I. D. Fernandez, Jacksonville.. Palatka Nov. 9 gia T. H. Goss. Athens Atlanta Oct. 11 Idaho* W. F. Howard. Pocatello Oct. 4 J. A. Egan. Springfield Chicago Oct ; ~.na W. T. Gott, Crawfordsville. . . .Indianapolis.. .Jan. 10 Louis A. Thomas. Des Moines. . Des Moines Kansas H. A. Dykes, Lebanon Topeka Oct. 1 1 Kentucky T. N. McCormack. Boiling Green Louisville Dec. 15 Louisiana A. B. Brown. Xew Orleans. . . . Xew Orleans. . .Oct. IS Maine F. W. Searle, Portland Portland Nov. 3 Maryland J. McP. Scott. Hagerstown. . . . Baltimore Dec. 13 Massachusetts*.]^. B. Harvey. State House. Boston Boston Nov. 8 Michigan B. D. Hanson. 205 Whitney Building, Detroit Lansing Oct. 11 a . . .W. S. Fullerton. St. Paul St. Paul Oct. 4 Mississippi. . - :uri Nebraska .... Nevada X. Hampshire Xew Jersey . S. H. McLean. Jackson Jackson Oct. 11 . Frank B. Hiller. Jerlerson Citv . Tefferson City . . . Wm. C. Riddell. Helena Helena '. . . Oct. 4 .C. A. Carr. Lincoln Lincoln Nov. 9 .S. L. Lee. Carson City Carson City. . . .Xov. 2 .Henry C. Morrison, State Li- brary. Concord Concord Jan. 3 .H. G. Xorton. Trenton Trenton Oct. 18 X'ew Mexico . . J. A. Massie. Santa Fe Santa Fe Oct. 10 Xew York Xew York C.F.W'neelock. Univ. of State J Albany Jan. 31 of Xew York. Albanv ] Svracuse . Buffalo j X. Carolina B. K. Hays. Oxford Charlotte. ..... Tune 14 X. Dakota H. M. Wheeler. Grand Forks.. Grand Forks. . .Oct. 4 Ohio Geo. H. Matson; Columbus. . . .Columbus Dec. 13 Oklahoma*... . .F. P. Davis. Enid Guthrie Oct. 11 Oregon B. E. Miller. Portland Portland Jan. 3 Pennsylvania* . X. C. Shaeffer. Harrisburg Philadelphia.. . . Dec. 6 Rhode Island*. . G. T. Swarts. Providence Providence Oct. 6 S. Carolina H. H.. Wyman, Aiken Columbus June 13 S. Dahota F. W. Freyberg. Mitchel Aberdeen Jan. 11 ' Memphis ] Tennessee C. A. Abernath\\ Pulaski. . . < Xashville. . . . > May 2 5 Knoxville. ... J Texas R. H. McLeod, Palestine Palestine . Xov. 22 Utah R. W. Fisher. Salt Lake City . . Salt Lake City. .Oct. 5 Vermont W. Scott Nay, Underhill Montpelier Jan. 10 Virginia R . S. Martin, Stuart Lynchburg Dec. 20 Washington*. . . F. P. Witter. Spokane Spokane Tan. 5 W. Virginia . . H. A. Barbee, Point Pleasant..Morgantown. . .Xov. 14 Wisconsin J. M. Berlel, Milwaukee Milwaukee Jan. 10 Wyoming S. B. 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It is conducted on the broadest lines, sparing no expense in the employment of its Editorial Staff, in collecting news, in maintaining correspondents in various parts of the world, and in securing exclusive reports of meetings by cable and telegraph. The Medical Record is independent of the control of any group of individuals or of any personal policy. It is controlled by the best judgment that long ex- perience of the needs of the better class of American physicians can give. Such experience teaches that the enlightened sentiment of the Profession is the only safe guide in this respect. a oeu*osrre r*o4iMtia MEDICAL RECORD A Weekly Journal of Medicine and Surgery WILLIAM WOOO AMD COMPANY PwMlahera. 01 fm* A»»f.o. New r«e» $5.00 Per Annum. Published at New York. Everv Saturday Single Copies, 15c. ORIGINAL ARTICLES. Radium 'or the Treairneni of Cancer ind Lupus By William Monoa >I O N'ew York Cutaneous Tuberculin "acrtnatton <1 the Diagnosis ol Tuberculosis. Sy William 1 Sutler M D Chicago Prevention of Death During Anesthesia b> Chloroform *nd Ether B> Rober* Reyburn. AM- HO Washington D C What Sfcan We r>> ••Itn Fat Advanced Career of .he Large Botiel* By R C Coffey H D- Portland. Ore Sanitation ot th» Canai Zone. Br Colonel William C Gorgas. M D Vaginal Implantation of Adencrarc! noma of Che Uterus Blood Metasta sis Multiple Short Incisions — Arterio- sclerosis — Vppet Respiratory Obstruc- tion «nd Oral Deformity , tubaruto Poly-myosiUs- Dementi} Prs- cos . Mutual Relations of Upper- Air .Tract. Ja»-a end Teeth— The Dtagnoste of Appendicitis — Corneal Anesthesia In Cerebrospinal Meningitis. ... . The Vaiue of Vaccina Therapv to the General Practitioner in the Treatment of Bacterial Disease BOOK REVIEWS. American Practice of Surgery A Com- plete System of the Science and Art of Surgery by neprcs«ntatl\<= Sur- Ceons of the United Stales and Can- ed* Editors Josenh D- Bryan M D. end Albert H Buck. 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