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Class 
 
 Book 
 
 (bpyrigM?. 
 
 CQEffilGHT DEPOSIT 
 
TREATISE ON 
 ORGANOTHERAPY 
 
Treatise on 
 
 ORGANOTHERAPY 
 
 AND 
 
 PLURIGLANDULAR THERAPY 
 
 By 
 CHARLES E. SPRING, M. D. 
 
 % 
 
 1921 
 
 PUBLISHED BY THE AUTHOR 
 
 Chicago, Illinois 
 

 Copyright, 1921, 
 
 BY 
 
 CHARLES E. SPRING, M. D. 
 
 All Rights Reserved 
 
 HAMMOND PRESS 
 B. CONKEY COMPANY 
 
 CHICAQO 
 
 JAN -3 1922 
 
 ©CU653400 
 
THE SCIENCE OF THE FUTURE 
 
 PHYSICIANS understand, though imperfectly, 
 that all pathological conditions may be effectu- 
 ally resisted by the organism itself, which fights 
 and defends itself energetically against its enemies. 
 This organism we little understand in spite of all 
 our microscopes, and the weapons with which it 
 guards itself are not well defined or known, but 
 they are nevertheless real and effective. Their 
 action is evidenced, if we merely recall the innu- 
 merable spontaneous cures that are noted in tuber- 
 culosis. 
 
 In the human organism we discover the true 
 panacea, for, as nature creates our enemies, it also 
 creates the opposing substances in order that we 
 may maintain our organic equilibrium. 
 
 Our scientific works on therapeutics will un- 
 dergo a radical transformation. That of the old 
 that is efficacious will remain, and the greater 
 needs of the future will be met with the series of 
 active glandular elements, or the true regulators 
 of health, which modern science is beginning to 
 know, although our knowledge is still amidst the 
 greatest obscurity and confusion, but it is genuine. 
 
INTRODUCTION 
 
 THE organs, tissues and secretions of animals 
 were extensively employed as remedial agents 
 in ancient times and many of them were official in 
 the pharmacopeias of the last century. Organo- 
 therapy is undoubtedly the oldest form of thera- 
 peutics. 
 
 The use of glandular products, as remedies in 
 pathological conditions, was recently revived by 
 Brown-Sequard in 1889. According to the theory 
 promulgated by them, all glands, in addition to their 
 ordinary secretions, put forth certain materials of 
 unknown chemical composition, which pass into the 
 blood and perform their definite functions of some 
 kind. We now know this to be a proven fact and 
 further that these glands of internal secretion exert 
 influence, heretofore unsuspected, over distant 
 parts of the organism. 
 
 I call your attention to the effect of the entire 
 removal of either the thyroid, parathyroid, pancreas 
 or adrenal glands. The effect is at once to produce 
 symptoms of characteristic and fatal disorders; but 
 if a portion of either of these glands is left, or a 
 portion of the gland engrafted, these toxic symp- 
 toms do not develop. 
 
 It is evident that these disorders, so produced, 
 are of auto-toxic origin, the result of chemical 
 
 9 
 
10 INTRODUCTION 
 
 poison in the blood, that is either eliminated, de- 
 stroyed or neutralized, when the gland or glands 
 are intact, performing their proper functions. 
 
 It has been demonstrated that the giving of a 
 properly prepared preparation of the dead gland 
 or a combination of glands, whichever is required, 
 will dispel the toxic phenomena, which fact goes 
 to prove that the active principle is a chemical sub- 
 stance, existing in the gland itself, and is not due 
 to the action of living cells, other than to produce 
 these active agents (hormones). The transfusion 
 of blood from a healthy to an unhealthy individual 
 is only the supplying of a normal stream of blood 
 charged, as it were, with its full quota of chemical 
 substance (the correct amount of hormones). The 
 results obtained, if done sufficiently early, are gen- 
 erally flattering, at least for a time, or until the 
 normal amount of hormones begin to lessen, pro- 
 vided nature is not able to assist the patient to 
 react and obtain his normal balance. This is one 
 of the demonstrations in favor of the pluriglandular 
 theory. 
 
 The initial dose of MANY animal extracts 
 should be very small and increased as conditions 
 may require. This is done to avoid the possible 
 systemic disturbance that has been noted in some 
 cases. However, the fact must not be lost sight of 
 that the patient must receive sufficient dosage 
 and it must be remembered that the giving of these 
 
INTRODUCTION 11 
 
 products should be over an extended period (for 
 months) to obtain the best results. 
 
 With certain exceptions animal products are 
 not toxic. The following preparations, however, 
 must be used with care. Thyroid product must be 
 started with a small dose and its reaction watched. 
 The extract of prostate is highly toxic; therefore 
 the initial dose must be small and the reaction care- 
 fully noted. The extracts of adrenal and pituitary 
 glands require judicious dosage, as harm might be 
 done by prescribing them in a haphazard manner 
 and over a too prolonged period. Care must be 
 taken in the giving of extracts of pancreas and 
 liver in diabetic cases, as extract of pancreas 
 should not be given in diabetes of hepatic origin 
 and vice versa. The other glandular extracts can 
 be given with comparative safety. 
 
 It has been proven that the endocrine glands 
 control metabolism, nutrition, development and 
 sympathetic functions. They work physiologically, 
 they are our regulators. The common expression 
 that a chain is no stronger than its weakest link has 
 no more fitting analogy than that we are no 
 stronger than our weakest endocrine gland secre- 
 tion. 
 
 It will be noted from the brief survey of hor- 
 mone-therapy that its uses are many and its appli- 
 cation is logical. It is obvious that at the present 
 time we are only on the fringe of the possibilities 
 
12 INTRODUCTION 
 
 of such treatment and that the near future will 
 develop great results. However, it must be re- 
 membered that organic diseases are not amenable 
 to organotherapy in the degree that functional dis- 
 orders respond to the treatment, though much will 
 be accomplished by the proper application of or- 
 ganotherapy. 
 
 In the therapeutic application of glandular ex- 
 tracts singly we have those products that are spe- 
 cific in action and produce a definite physiological 
 effect. 
 
 First. Products that produce an effect which 
 is not due to any change in the normal hormone 
 production, as is noted in the action on the un- 
 striped muscles, by the giving of an extract of the 
 posterior lobe of the pituitary. Especially is this 
 marked on the uterine muscles. 
 
 Second. Products that effect the normal hor- 
 mone production. The extract of a gland, when 
 given internally, tends to augment the action of 
 the same gland and possibly will restore the gland, 
 partially, or in whole, to normal health, as the giv- 
 ing of ovarian extracts in ovarian troubles and 
 thyroid extract in hypothyroidism. 
 
 Third. Products used without a definite specific 
 or scientific basis in which the beneficial results 
 have been noted, as the giving of parathyroid in 
 paralysis agitans and pituitary in functional ovarian 
 troubles. 
 
INTRODUCTION 13 
 
 Fourth. Products that supply the required hor- 
 mones of those glands that have been removed, 
 destroyed or do not function, as the supplying of 
 thyroid in cases of myxedema. As the time passes 
 and a more extensive clinical knowledge is obtained 
 of the endocrine glands, their use will become one 
 of a more specific application to pathological con- 
 ditions. 
 
 Fifth. The pluriglandular therapy has proven 
 itself to be worthy of our profound thought and 
 investigation, as it will prove one of our greatest 
 weapons in combating pathological conditions. 
 There never was a uniglandular endocrine disorder 
 that could exist for any length of time singly, as, 
 at once, it will involve other endocrine glands, 
 therefore becoming pluriglandular, and the best 
 possible manner to meet these pathological condi- 
 tions is to employ a pluriglandular product that is 
 therapeutically and synergistically indicated to 
 meet the conditions. 
 
 The use of drugs should be employed in con- 
 nection with organotherapy, or vice versa. The 
 proper body and mental conditions of the patient 
 must be looked after, as well as the hygiene and 
 dietetics. 
 
 With these introductory remarks, we will pass 
 on to the discussion of the endocrine glands and 
 from there to the pluriglandular therapeutics. 
 
Treatise on Organotherapy 
 
 ADRENAL GLANDS 
 
 Source and Parts Used. The adrenal or 
 suprarenal glands of various animals are used, 
 chiefly those of cattle and sheep. There are three 
 preparations, namely, the whole gland, the central 
 or medulla and the peripheral or cortex. One part 
 of the adrenal powder represents about six parts 
 of the fresh gland. There is a synthetic preparation 
 made that is identical or closely allied chemically. 
 
 Anatomy and Physiology. The suprarenal 
 glands, each weighing from sixty to one hundred 
 and twenty grains, are two flattened bodies more 
 or less globular in shape, of a yellowish color, 
 situated behind the peritoneum and in front of the 
 upper part of each kidney. The adrenal glands, 
 through their hormones, supply the tonicity of the 
 involuntary muscles. Upon adrenal action on the 
 cardiac and circulatory system, blood pressure 
 greatly depends. Adrenal insufficiency is not an 
 uncommon condition and has been shown to be 
 stimulated by emotional strains (as worry, pain or 
 fear). Infectious or toxic diseases are conditions 
 of acute adrenal depletion. This same condition, 
 
 15 
 
16 TREATISE ON 
 
 no doubt, exists in long standing infections, as 
 tuberculosis and malnutrition. The active principle 
 secreted is adrenalin. 
 
 Central Portion or Medulla is formed of stout 
 connective tissue, with highly vascular cells, em- 
 bodied in a venous plexus, and is very closely allied 
 to the nervous system. In reality, it is said to be a 
 part of it. 
 
 Cortex or Peripheral has quite a different his- 
 tological structure and physiological action is quite 
 different than the medullary part of these glands, 
 as the apparent action of this part of the gland is 
 to neutralize poison liberated during muscular 
 energy. The adrenal glands control development 
 of the gonads. 
 
 Therapeutic Indication — Total Gland. Muscular 
 fatigue, atony and run down conditions, cardiac and 
 circulatory insufficiency, cold extremities, malnutri- 
 tion, asthenia, tuberculosis, cachexia, Addison's dis- 
 ease, toxic conditions, bronchial asthma, cholera, 
 collapse, shock and vomiting of pregnancy. 
 
 Principal Indications Adrenal Total. Muscular 
 atony, low vitality, fatigue, cardiac insufficiency, 
 bronchial asthma, vomiting of pregnancy and hypo- 
 tension. The giving of this product requires great 
 care and is not suitable for prolonged administra- 
 tion. NOT to be GIVEN in high blood pressure 
 or arterio-sclerosis. 
 
 Therapeutic Indication — Central Portion or 
 
ORGANOTHERAPY IT 
 
 Medulla. Is limited to local use and used in the 
 usual chloride solution of 1 to 1,000, as in local con- 
 gestions and hemorrhages, conjunctivitis, coryza, 
 hay fever, hemorrhage from nose, iritis, keratitis, 
 laryngitis, rhinitis or in cases where a vasocon- 
 strictor is required. Internally of benefit in bron- 
 chial asthma, shock, heart failure, or in cases where 
 vasomotor equilibrium is to be controlled. 
 
 Principal Indications Adrenal Medulla. Gener- 
 ally limited to local use in surgery, as a vasocon- 
 strictor. Also used locally in coryza, nose bleed, 
 hay fever, and local congestions. Used internally 
 in asthma, bronchial spasms and severe infectious 
 diseases. 
 
 Therapeutic Indication Cortex. This product 
 is not often used alone, but has been given to 
 hasten osseous development and union of fractures. 
 May be used in conditions due to defective ovarian 
 or testicular development. 
 
 Principal Indications Adrenal Cortex. Defec- 
 tive development of gonads. Assists absorption 
 and retention of lime; therefore helpful in growth 
 of osseous tissue and union of fractures. Has anti- 
 toxic properties. 
 
 Counter-indicated. Diabetes Mellitus, vascu- 
 lar diseases with hypertension, aneurysm, high 
 blood pressure, pulmonary hemorrhage. 
 
 Synergistics. Animal extracts that exert mus- 
 cular tone and increase blood pressure. The 
 
18 TREATISE ON 
 
 suprarenal capsule, total gland, is frequently com- 
 bined with ovary, testicle, thyroid and pituitary. 
 
 Dose. Adrenal total gland, one-half to two 
 grains. Tablets of one-half grain. Adrenal medulla 
 is given according to the acute or chronic condi- 
 tions from one-tenth to two grains and larger 
 doses. The 1 to 1,000 chloride solution, two to ten 
 minims. Tablets of 1/10 grain. Adrenal cortex, 
 two to five grains. Tablets of two grains. These 
 preparations are to be given three to four times 
 daily. 
 
 APPENDIX 
 
 Source and Parts Used. The mucous mem- 
 brane of the appendix of hogs is the part used. 
 This part is desiccated and powdered. One part 
 of the powdered substance represents about twelve 
 parts of the fresh membrane. 
 
 Anatomy and Physiology. The appendix, which 
 varies from 4 to 6 inches in length, is attached to 
 the cecum and is rudimentary in human beings. It 
 is said that this organ produces a substance which 
 stimulates peristalsis. 
 
 Therapeutic Indication. Digestive disorders, 
 intestinal stasis, constipation. 
 
 Dose. Has been used experimentally and is not 
 yet well established. 
 
ORGANOTHERAPY 19 
 
 BLOOD 
 
 Source and Parts Used. Hemoglobin, which 
 represents the largest portion of the colored cor- 
 puscles, is obtained from the red blood cells of cat- 
 tle, is desiccated and put into powder form. 
 
 Normal Serum. This product is obtained from 
 the healthy horse and can be obtained in ampules 
 or syringes for immediate use. 
 
 Antithyroid Serum. This serum is taken from 
 the horse five or six weeks after the thyroid gland 
 has been removed. This product is rarely used. 
 
 Leucocyte Extract. This product is obtained 
 by the injection of irritating substances into the 
 pleural cavity of the horse or of other animals. The 
 exudate is aspirated, the cellular element is separ- 
 ated, incubated and is available in ampules. 
 
 Anatomy and Physiology. The blood is the 
 fluid medium through which all tissues of the body 
 are directly or indirectly nourished and represents 
 about one-twelfth to one-fourteenth of the weight 
 of the body. It has slightly alkaline reaction. The 
 fluid part of the blood is called plasma, a colorless 
 fluid, and suspended therein are the white and red 
 corpuscles. 
 
 Hemoglobin. This product represents organic 
 iron and about 90 per cent of the red blood cor- 
 puscles. The red blood corpuscles are the oxygen- 
 carrying element of the blood. 
 
20 TREATISE ON 
 
 Normal Serum. The serum contains forma- 
 tions of other products that are required to main- 
 tain the normal health balance. Normal serum is 
 given in cases of infection and hemorrhagic dis- 
 eases. 
 
 Antithyroid Serum. It is presumed that by the 
 removal of the thyroid the blood becomes charged 
 with elements normally held in check by the secre- 
 tions of the thyroid. Therefore the antithyroid 
 serum is thought to neutralize the toxic product of 
 thyroid activity. 
 
 Leucocyte Extract. This product produces a 
 decided artificial immunity in infectious diseases 
 and relieves overworked leucocytes, thereby pro- 
 tecting the higher cells, so that their function is not 
 deranged by excessive toxic conditions. 
 
 Therapeutic Indication. Hemoglobin (organic 
 iron) is indicated in anemia, chlorosis, malnutrition, 
 pernicious anemia and in cases where a general 
 systemic tonic is required. 
 
 Synergistics. Thyroid extract in anemia show- 
 ing hypothyroidism. This product may also be 
 given in combination with spleen extract. 
 
 Dose. Two to five grains, three times per day, 
 at meals. Tablets of two grains. 
 
 Normal Serum. Hemorrhages due to defective 
 clotting and used as immune serum in septic condi- 
 tions, as found in pneumonia, typhoid fever and 
 kindred conditions. 
 
ORGANOTHERAPY 21 
 
 Administration and Dose. May be applied lo- 
 cally or injected by methods provided. 
 
 Antithyroid Serum. Indicated in excessive 
 secretion of the thyroid gland, Grave's disease. 
 
 Synergistics. Desiccated pancreas, adrenal, 
 pituitary. 
 
 Dose. Five grains of powder, two to three 
 times per day, given over an extended period of 
 time. 
 
 Leucocyte Extract. Severe infections, sep- 
 ticemia, pyemia, cerebro-spinal meningitis. 
 
 Synergistics. Nuclein and hemoglobin may be 
 given with this product, where there is marked 
 anemia, in cases of prolonged systemic infection. 
 This product is given hypodermically. 
 
 BONE 
 
 Source and Parts Used. The long bone of vari- 
 ous animals, from which the organic matter has 
 been extracted, desiccated and put in powdered 
 form, is used. 
 
 Anatomy and Physiology. The mineral salts ob- 
 tained from bone are said to be easily assimilated 
 and produce influence on nutrition and mineral 
 metabolism. 
 
 Therapeutic Indication. Indicated in those cases 
 in which there is lack of mineral salts, as in malnu- 
 
22 TREATISE ON 
 
 trition, rickets, tuberculosis, and other forms of 
 metabolic dyscrasia. Indicated mineral salts can 
 be used with as much benefit as that of bone. 
 
 Dose. Five to ten grains or more, with meals. 
 Tablets of five grains. 
 
 BONE MEDULLA 
 
 Source and Parts Used. The medullary part of 
 the long bones of young animals is the part used. 
 Available in powder. 
 
 Anatomy and Physiology. The extract of bone 
 marrow is stimulating and increases both the white 
 and red blood corpuscles. 
 
 Therapeutic Indication. This product is indi- 
 cated in anemia, pernicious anemia, malnutrition, 
 chlorosis, tuberculosis, albuminuria and in cases 
 where there is a necessity for an increase in the 
 production of the red and white corpuscles. 
 
 Synergistics. Hemoglobin, spleen substance, 
 also indicated with restorative drug medications. 
 
 Dose. Five to ten grains of extract four times 
 per day after meals. Tablets of five grains. 
 
 BRAIN AND SPINAL CORD 
 
 Source and Parts Used. The brain, cord and 
 nervous tissue from the sheep are the parts used. 
 
ORGANOTHERAPY 23 
 
 With the fat removed, one part of the desiccated 
 substance represents about five of the fresh gland. 
 
 Anatomy and Physiology. There are two di- 
 visions of the nervous system, the cerebro-spinal 
 and the sympathetic. The former is composed of 
 the brain, spinal cord, cranial and spinal nerves. 
 The latter consists of a series of ganglia with inter- 
 vening bands, forming two cords, one on either 
 side of the spinal column. There are three plexuses, 
 one in the thorax, one in the abdomen and one in 
 the pelvis. There are also many small ganglia 
 connected with the sympathetic system, supplying 
 the viscera, vessels and all other parts of the body. 
 Nerve fibres of communication unite the sympa- 
 thetic and cerebro-spinal nerves. Nervous tissue is 
 divided into two classes, white and gray. 
 
 Therapeutic Indication. The brain and nerve 
 substance contains four elements, chief among 
 which are lecithin and cholesterin, as well as other 
 stimulating properties that act upon nutrition of 
 the nervous system. There is an emulsion made 
 from the white substance of the brain of cattle 
 (Thromboplastin), that is used locally as a hemo- 
 static in hemorrhages from the nose, throat or after 
 removal of tonsils or adenoids, gastric ulcers, 
 hemorrhages from hemorrhoids and other local 
 hemorrhages. Lecithin is rich in assimilable form 
 of organic phosphorus and is therefore a prepara- 
 tion of reconstructive merit and is useful as a 
 
24 TREATISE ON 
 
 cerebrospinal tonic in depraved conditions. It is 
 indicated in neurasthenia, debility, malnutrition 
 and in cases where phosphorus is indicated, mental 
 and nervous disorders, functional impotence, prem- 
 ature senility, hysteria and epilepsy. 
 
 Principal Indications. Loss of nerve energy, 
 malnutrition, mental and nervous disorders, func- 
 tional impotence, premature senility, neurasthenia, 
 locomotor ataxia, chlorosis and profound anemia. 
 
 Counter-indicated. Hemorrhage arterial. 
 
 Synergistics. Hemoglobin, adrenal, spermin 
 and nuclein. 
 
 Dose. The desiccated powder, one to three 
 grains, three to four times per day. Lecithin con- 
 tains 5 per cent of organic phosphorus and is given 
 in doses of from one-half to three grains, three 
 times per day. This is one of the most useful forms 
 of assimilable phosphorus. Tablets of brain and 
 spinal cord, one grain. 
 
 CAROTID GLAND 
 
 The carotid gland has been considered part of 
 the nervous system, vascular, and now a portion of 
 the adrenal system. All do not agree that this 
 gland has an internal secretion. From experiments 
 with this gland conclusions are formed for and 
 against. Further investigation is necessary to de- 
 
ORGANOTHERAPY 25 
 
 termine the merits of this gland for use in organo- 
 therapy. 
 
 DUODENUM— (Secretin) 
 
 Source and Parts Used. About eighteen or 
 twenty inches of the upper portion of the mucous 
 membrane of the small intestine of pigs is part 
 used. Secretin is extracted by means of hydro- 
 chloric acid from the scrapings of this portion of 
 the small intestine. One part of the desiccated 
 extract represents about twelve parts of the fresh 
 scrapings. 
 
 Anatomy and Physiology. This part of the 
 small intestine begins at the pyloric end of the 
 stomach and is about twelve inches long. About 
 two or two and one-half inches from the pyloric 
 end of the stomach open the pancreatic and 
 hepatic ducts. The duodenum is composed of the 
 same coats as the stomach. The mucous mem- 
 brane consists of a series of folds and is covered 
 with columnar epithelium, containing the villi of 
 the intestines and glands. Secretin is described as 
 the alimentary hormone and has a stimulative effect 
 upon the alimentary glands, increasing the action 
 of the digestive fluids and their enzymes. It has 
 a decided influence upon peristalsis and stimulates 
 flow of bile. 
 
 Therapeutic Indications. Secretin is indicated 
 
26 TREATISE ON 
 
 in intestinal indigestion, where either the pancreas 
 or liver, or both, are at fault, clay colored stools. 
 It is indicated in cases where food undergoes putre- 
 faction in the intestinal tract, autotoxemia, hepatic 
 cirrhosis, jaundice, diarrhea of children and consti- 
 pation. This product has also been recommended 
 in diabetes, but only for its effect on digestion. It 
 should be a very useful product in acute and chronic 
 conditions, where digestion and nutrition might be 
 involved. Secretin may be called the key which 
 unlocks the alimentary glands. 
 
 Counter-indicated. Ulcer of the small intes- 
 tine and inflammation of the pancreas and liver. 
 
 Synergistics. Pancreatin, papain and other 
 products influencing digestion. 
 
 Dose. Secretin, two to four grains given while 
 or after eating. Duodenum extract tablets of two 
 grains. 
 
 KIDNEYS— ( Nephritin) 
 
 Source and Parts Used. Glomerular substance 
 of the kidneys of hogs, sheep and cattle is used. 
 One part of the dried powder equals about eight 
 parts of the fresh gland (Nephritin). 
 
 Anatomy and Physiology. The kidneys, two 
 in number, are situated on either side of the verte- 
 bral column. They reach from the twelfth dorsal 
 to the third lumbar vertebra, the right kidney being 
 
ORGANOTHERAPY 27 
 
 a little lower than the left. Each weighs from four 
 to six ounces. The kidneys, consisting of the cor- 
 tical substance, the medullary and the pelvis, are 
 enveloped in a strong capsule. They exert a specific 
 and neutralizing effect in toxemia and have an in- 
 fluence upon irritating substances of the blood that 
 effect the secreting part of the kidneys. They are 
 also diuretic. 
 
 Therapeutic Indication. Extract of the kidneys 
 is indicated in renal insufficiency, uremia, albu- 
 minuria (Bright's disease) and in cases of ascites 
 and dropsy that are caused by renal insufficiency 
 and lack of nitrogenous metabolism. This product, 
 in combination with remedial agents, where dropsy 
 or ascites may be due to heart or liver lesion, will 
 be found of much service. It has also been known 
 to increase elimination of urea. 
 
 Synergistics. Desiccated liver and pancreas 
 substance. This product is also used with other 
 animal extracts. 
 
 Dose. Nephritin, three grains of desiccated 
 kidney substance, three times per day after meals. 
 To be increased as conditions demand. Tablets of 
 three grains. 
 
 LIVER AND BILE 
 
 Source and Parts Used. The parenchyma of 
 the liver of cattle and hogs is used. One part of 
 
28 TREATISE ON 
 
 the desiccated liver substance represents about six 
 parts of the fresh gland. 
 
 Anatomy and Physiology. The liver, the largest 
 gland in the body, weighing about four pounds, 
 occupies the right hypochondrium region. It is 
 composed of lobules from one-tenth to one-twen- 
 tieth of an inch in diameter, bound together by loose 
 areolar tissue. Each lobule consists of nucleated 
 hepatic cells, which form the secreting part of the 
 liver. The amount of bile secreted by the hepatic 
 cells is influenced by the amount of its blood sup- 
 ply. The secretion is increased during digestion 
 and retarded between meals. During digestion the 
 bile is secreted and carried by the main hepatic duct 
 directly into the duodenum and after digestion is 
 completed, the bile regurgitates from the common 
 bile duct, through the cystic duct, into the gall 
 bladder, where it accumulates for the next digestive 
 period. The hepatic cells are concerned in the regu- 
 lation of the sugar contents of the blood. 
 
 Therapeutic Indication. Desiccated liver sub- 
 stance has been used with success in the treatment 
 of functional hepatic disorders, as well as conditions 
 of an organic nature, as atrophy, cirrhosis and alco- 
 holic derangement. 
 
 It is also used in the treatment of diabetes that 
 is attributed to disturbance of the liver function. 
 This form of diabetes is not as prevalent as pan- 
 creatic diabetes. Desiccated liver substance given 
 
ORGANOTHERAPY 29 
 
 in diabetes of a pancreatic origin aggravates the 
 difficulty. Liver substance has been found of value 
 in the treatment of rheumatism and gout and is 
 also known as an anti-hemorrhagic. 
 
 Counter-indicated. Pancreatic diabetes. 
 
 Synergistics. Spleen substance, bile salts and 
 possibly thyroid extract. 
 
 Dose. Five to fifteen grains, three to four times 
 per day. Increased as desired. Tablets of five 
 grains. 
 
 Therapeutic Indication — Bile. Bile is the most 
 efficient cholagogue. In intestinal digestion it as- 
 sists in emulsifying the fats of the food and renders 
 it capable of lacteal absorption. It lubricates the 
 mucous membrane of the intestinal tract, is an anti- 
 septic, prevents the decomposition of food through 
 the intestines and acts as a natural purgative by 
 stimulating the muscular and mucous coats of the 
 intestinal tract. Bile salts are indicated in hepatic 
 insufficiency, indigestion, constipation and forma- 
 tion of gas in the intestinal tract, due to biliary 
 insufficiency, and in cases where there is a lack of 
 digestion of the fats, as found in children. Dehy- 
 drated bile represents about forty parts of the fresh 
 fluid. 
 
 Counter-indicated. Obstructive jaundice and 
 pancreatic diabetes. 
 
 Synergistics. Hepatic substance. Also pancre- 
 atin is very often used with this product. 
 
30 TREATISE ON 
 
 Dose. Two to five grains of the desiccated 
 product, to be increased as indicated. Tablets of 
 two grains. 
 
 LUNGS 
 
 Source and Parts Used. Lung tissues from ani- 
 mals, preferably lambs, is used. Is desiccated and 
 powdered. 
 
 Anatomy and Physiology. The lungs are the 
 two organs of respiration, occupying the major por- 
 tion of the thoracic cavity, weighing, the right 
 twenty-two ounces and the left twenty ounces. The 
 right has three lobes and the left two. They are of 
 a spongy, elastic texture. The pulmonary par- 
 enchyma is formed of lobules composed of a ter- 
 minal bronchial tube, air cells, blood vessels, nerves 
 and lymphatics, with a small amount of areolar 
 tissue. The small air cells measure one-hundredth 
 of an inch in diameter. 
 
 Therapeutic Indication. The active principle 
 of the lung extract exerts a tonic action upon the 
 respiratory tract, especially on the mucous mem- 
 brane of the bronchi and pulmonary alveoli. Lung 
 extract has been recommended in chronic diseases 
 of the lung and pleura, especially those of a puru- 
 lent character, and has been used with benefit in 
 cases of chronic bronchitis, diseases of the pul- 
 monary tissue, purulent pleurisy, pulmonary tuber- 
 
ORGANOTHERAPY 31 
 
 culosis, pulmonary abscess and emphysema, and is 
 said to be of benefit in cases of pulmonary hemor- 
 rhages. 
 
 Dose. Five to twenty grains, four to five times 
 daily for an extended period. Tablets of five grains. 
 
 LYMPHATIC GLANDS 
 
 Source and Parts Used. Lymphatics of cattle 
 are parts used. One part of the desiccated sub- 
 stance represents about five parts of the fresh gland. 
 This product is very hygroscopic. 
 
 Anatomy and Physiology. The lymphatics are 
 transparent vessels, having the same three coats as 
 the arteries and veins and are to be found every- 
 where in the body with the exception of the nails, 
 cuticle, hair and cartilage. They are supplied with 
 numerous valves, which give them a beadlike ap- 
 pearance. Lymphatics of the mesentery and small 
 intestine carry the chyle during digestion and the 
 lymph at other times. The lymphatic glands are 
 small, solid, round or oval bodies situated along the 
 absorbent vessels. The glands break up into sev- 
 eral afferent vessels and form plexuses within and 
 emerge efferent vessels, which soon unite in a single 
 trunk. The lymphoid tissue is filled with lymph- 
 cells. These glands are to be found in the mesen- 
 tery and along great vessels in the axilla, neck and 
 
32 TREATISE ON 
 
 groins through which the lymph passes in its 
 course, before being discharged into the blood ves- 
 sels. It might be said that they act as filters. 
 Materials of food not taken directly into the blood 
 vessels of the alimentary canal are received by the 
 lymphatic absorbents, taken and emptied into the 
 lymphatic duct. The lymphatic duct is about 
 eighteen inches long and empties into the junction 
 of the left internal jugular and subclavian veins, 
 where the lymph and chyle are carried and injected 
 into the circulation. The right lymphatic duct is 
 very small and empties into the junction of the 
 right internal jugular and subclavian veins. 
 
 Therapeutic Indication. This product has been 
 found of benefit in cases of poorly nourished chil- 
 dren, enlarged glands, adenoids and cases that are 
 subject to hemorrhages. Also recommended for 
 individuals where reconstructive treatment is re- 
 quired and might be found of benefit in tubercular 
 conditions. 
 
 Synergistics. Thyroid, spleen, spermin and 
 orchic substance, calcium salts and drug medication 
 as indicated. 
 
 Dose. One-half to one grain of desiccated 
 glandular substance, three times per day, to be 
 increased as required. Tablets of one-half grain. 
 
ORGANOTHERAPY 33 
 
 MAMMARY GLANDS 
 
 Source and Parts Used. The parenchymatous 
 portion of the mammary gland of udders of goats, 
 ewes and cows is part used. One part of desic- 
 cated gland represents about four to five parts of 
 fresh parenchyma. 
 
 Anatomy and Physiology. The mammary gland, 
 which varies in size and weight, is composed of 
 lobes, which are subdivided into lobules, bound to- 
 gether with connective tissues. The lobules form 
 a number of rounded vesicles in groups into which 
 their ducts open and by their union form about 
 fifteen or twenty excretory ducts. Internal secre- 
 tion of the mammary gland antagonizes that of 
 corpus luteum, and as a result inhibits activity of 
 the ovaries. The active principle stimulates the 
 mammary activity and development. It reduces 
 congestion of the uterus and favors uterine involu- 
 tion after childbirth. 
 
 Therapeutic Indication. Found of benefit in 
 uterine hemorrhages due to cancer, fibroids, menor- 
 rhagia and metrorrhagia, metritis and endometritis. 
 This product is said to be of benefit also in deficient 
 lactation and given with the view of overcoming 
 complications of the menopause. 
 
 Counter-indicated. Where there is deficient 
 ovarian activity and amenorrhea. 
 
 Synergistics. Total pituitary, placental extract 
 
34 TREATISE ON 
 
 and products which exert similar galactogenic ac- 
 tion. Possibly thymus extract could be used with 
 benefit. Mammary extract has been known to pro- 
 duce slight gastric irritability. In this case it should 
 be discontinued for the time being. 
 
 Dose. Two to ten grains, two to three times 
 per day, after meals. Tablets of two grains. 
 
 MELANINE 
 
 There exists a coloring matter known as mel- 
 anine, that is found in all colored tissues of the body, 
 and also forms the principal coloring matter of the 
 hair. Melanine appears to contain most of the iron 
 derived from destructive assimilation of the blood 
 globules. When this product is isolated, it is found 
 to be of a dark blackish-brown color and may pro- 
 duce all the varying grades of hue to nearly abso- 
 lute black. This product is deposited in the 
 substance of the cells in the form of minute 
 granules. Further research may develop some- 
 thing along these lines. 
 
 OVARIES 
 
 Source and Parts Used. The whole ovary from 
 cows and sows is used. One part of the ovary, 
 
ORGANOTHERAPY 35 
 
 desiccated (powdered), represents about six and 
 one-half of the fresh ovary. The corpus luteum 
 for a time practically supplanted the extract of the 
 ovary. One part of the desiccated corpus luteum 
 represented about five parts of the fresh gland. 
 
 Anatomy and Physiology. The ovaries, which 
 weigh from sixty to one hundred and twenty 
 grains, are two flattened oval bodies situated in the 
 cavity of the pelvis, one on each side, and are ad- 
 herent to the posterior surface of the broad liga- 
 ment by their anterior border. They are composed 
 of fibrous stroma and connective tissue in which 
 are embedded Graafian follicles. The corpus 
 luteum, an irregular spot in the ovary, is the site 
 of a ruptured Graafian follicle. Both the ovaries 
 and the corpus luteum produce very active internal 
 hormones or secretions which, no doubt, have to 
 do with the control of menstruation and pregnancy. 
 They regulate both metabolism and oxidation pro- 
 cesses of the body and their administration stimu- 
 lates the secretory activity of the ovaries. 
 
 Therapeutic Indication. The removal of the 
 ovaries will arrest development, but the transplant- 
 ing of the ovarian tissue, under the skin, at once 
 remedies these defects, showing that the hormone 
 is chemical and not reflex in its action. If the 
 ovaries are destroyed by disease or otherwise, ad- 
 ministration of the ovarian extract overcomes the 
 nervous mental and circulatory disturbances, with 
 
36 TREATISE ON 
 
 which every physician is familiar. Ovarian extract 
 will be found of much therapeutic efficiency when 
 administered in functional and organic ovarian dis- 
 turbances, such as amenorrhea, dysmenorrhea, neu- 
 rosis and reflex conditions, as dizziness, insomnia, 
 palpitation, intermittent pulse and mental condi- 
 tions associated with these troubles. The relation 
 between the ovarian secretion and osteomalacia has 
 been subject to much speculation, but it is likely 
 that the ovaries more than any other endocrine 
 gland, as the thyroid and thymus, are the most con- 
 cerned in the production of the disease. The men- 
 tal disturbance at the climacteric is relieved by 
 ovarian extract. 
 
 Counter-indicated. Pregnancy, cases of hyper- 
 secretion of the ovary, extreme pelvic congestion. 
 
 Synergistics. Thyroid extract can be given with 
 ovarian extract, but not where there is hyperthy- 
 roidism. Total pituitary gland is used. 
 
 Dose. Two to four grains, three times per day, 
 between meals, to be increased as indicated. This 
 treatment should be given over an extended period 
 in order to obtain necessary results. Tablets of two 
 grains. 
 
 Corpus Luteum. The therapeutic possibilities 
 of ovarian extract are numerous. There exists an 
 intimate relation between the thyroid and pituitary 
 glands and the ovaries. Ovarian extract is fre- 
 quently indicated in disorders of the pituitary, more 
 
ORGANOTHERAPY 37 
 
 especially when the symptoms point to excessive 
 osseous growth in imperfect development. Nearly 
 all these patients are inclined to take on flesh, 
 whether the deficiency arises in the pituitary, thy- 
 roid or ovaries. If there be thyroid insufficiency, 
 the patient will have a harsh and rough skin and 
 the blood pressure will usually be normal (125 mm. 
 Hg.) or a little above. If there be pituitary insuf- 
 ficiency, the skin will be soft and smooth and the 
 blood pressure will be considerably below normal. 
 
 The secretions of the ovaries are not confined 
 entirely to the corpus luteum. We do know, how- 
 ever, that corpus luteum is intimately associated 
 with nutrition, menstruation, ovulation and lacta- 
 tion. The female, during the child-bearing period, 
 under normal health, is constantly absorbing corpus 
 luteum and, as soon as the corpus luteum of one 
 menstrual period has been absorbed, another ap- 
 pears to take its place during the next period. 
 During the first ten to twelve weeks of pregnancy 
 corpus luteum ceases to be absorbed, though it in- 
 creases much in size and from this time on is 
 gradually taken up by the body. If you note, the 
 nausea of pregnancy begins during this period and 
 disappears as absorption begins to take place. It 
 is evident that the nausea of pregnancy may depend 
 much upon this condition. 
 
 Corpus luteum extract has remedial action only 
 in the female and acts more efficiently during the 
 
38 TREATISE ON 
 
 child-bearing period or during this period of absorp- 
 tion. The giving of corpus luteum causes a reten- 
 tion of nitrogen, a tendency toward the obese and 
 a development of the mammary glands. Corpus 
 luteum is also a marked vasodilator. The giving of 
 an extract of the ovary, where all the Graafian 
 follicles have been removed, has quite an opposite 
 therapeutic action to that of corpus luteum. Cor- 
 pora Lutea are not found in the fetus, girls before 
 puberty or women who have ceased to menstruate. 
 It is therefore evident that corpus luteum is a true 
 puberty body. 
 
 The chemical or active principle of corpus 
 luteum has not been determined. 
 
 Counterindicated. Low blood pressure and 
 frequent menstruation. 
 
 Synergistics. Thyroid and pituitary. 
 
 Therapeutic Indication. Functional amenor- 
 rhea of girls and young women, dysmenorrhea, 
 abrupt menopause, neurasthenia associated with 
 menstrual disorders and irregular menstruation ac- 
 companied with overweight. For relief of per- 
 sistent headaches at cyclic periods, this is to be 
 given several days before the menstruation. 
 
 Dose. One-half to three grains four times a 
 day. 
 
ORGANOTHERAPY _39 
 
 PANCREAS 
 
 Source and Parts Used. The pancreatic gland 
 is obtained from cattle and hogs. The desiccated 
 acinus portion is used. One part of the desiccated 
 gland represents about five parts of the fresh. This 
 preparation is hygroscopic. 
 
 Anatomy and Physiology. The pancreas, a com- 
 pound racemose gland, is pyramidal in shape, about 
 six inches long, one-half inch wide and one inch 
 thick and weighs from two to four ounces. It lies 
 behind the stomach and in front of the first lumbar 
 vertebra. Its chief function is facilitating the metab- 
 olism of carbohydrates. At the splenic or tail end 
 of the gland are found from 80 to 90 per cent of 
 the islands of Langerhan. Pancreatin, a combi- 
 nation of enzymes and well known digestive fer- 
 ments, acts only in an alkaline medium. The pan- 
 creas produces three well known digestive ferments, 
 trypsin, steapsin and amylopsin. These ferments 
 take part in the digestion of proteids, fats and car- 
 bohydrates. Pancreatic digestion takes place in 
 the small intestines. It is quite well established 
 that the internal secretion of the pancreas facili- 
 tates the burning of the sugar in the muscles and 
 reduces blood pressure. The removal of the whole 
 pancreas is followed in a short time by fatal dia- 
 betes, whereas if pancreatic substance is grafted 
 into the animal, glycosuria is prevented. The dia- 
 
40 TREATISE ON 
 
 betic possesses little phagocytic resistance, is sub- 
 ject to infection and is a bad subject for operation. 
 He has also little power of resisting tubercle bacil- 
 lus. 
 
 Therapeutic Indication. The use of pancreatin 
 in intestinal indigestion and for peptonizing milk 
 has been well established. One of the principal 
 uses of the pancreas substance is to antagonize 
 hyperfunction of the adrenal gland in high blood 
 pressure and is of benefit in infection of the adrenal 
 gland by bacterial and other toxic conditions. It 
 is also indicated in pancreatic diseases, where there 
 is a lack of the functioning of the gland. Owing 
 to its sedative action, it would perhaps be found 
 of benefit in Grave's disease. Trypsin has been 
 used as a diphtheritic solvent. Pancreas may be 
 found of benefit in diabetes mellitus of pancreatic 
 origin. It is useful in lowered vitality to prevent 
 infections and is recommended in tuberculosis. The 
 dropping of a solution of adrenalin in the eye of an 
 animal from which the pancreas has been removed 
 causes dilatation of the pupil, which action does not 
 occur in a normal animal. This test is used at times 
 to diagnose pancreatic diabetes from liver diabetes. 
 
 Counter-indicated. In diabetes of hepatic origin. 
 
 Synergistics. Digestive ferments, papain, small 
 doses of thyroid in hypertension, adrenal substance 
 and posterior pituitary. 
 
 Dose. Two to eight grains, three to four 
 times per day. Tablets of two grains. 
 
ORGANOTHERAPY 41 
 
 PARATHYROID GLANDS 
 
 Source and Parts Used. The parathyroid glands 
 are obtained from cattle and horses. The glands 
 are desiccated and powdered. One part of the 
 powdered substance represents six parts of the 
 fresh gland. 
 
 Anatomy and Physiology. These glands are 
 situated in the throat and are four in number, two 
 pairs, situated in close proximity to the lateral 
 lobes of the thyroid gland. The structure bears 
 some resemblance to the thyroid gland. The 
 glands are formed of columns of granular epithe- 
 lium cells and show very vascular connective tis- 
 sue between them. Upon the removal of the 
 thyroid gland, these glands undergo marked hyper- 
 trophy. Parathyroid glands control the destruction 
 of toxic substance and are intimately concerned in 
 the maintaining of calcium metabolism, therefore 
 having a special effect on the nervous system. The 
 total removal of these glands is followed by tetany 
 and a serious loss of calcium salts, rapidly causing 
 death. 
 
 Therapeutic Indication. With the loss of para- 
 thyroid secretion there is a marked nervous irrita- 
 bility, bordering on tetany. Therefore the ad- 
 ministration of this product in nervous, irritable 
 conditions is received with favor. This product 
 has also proven of benefit in the controlling of con- 
 
42 TREATISE ON 
 
 vulsions, paralysis agitans and has been found of 
 benefit in the treatment of chorea, epileptic convul- 
 sions and exophthalmic goiter. 
 
 Synergistics. Bile salts, testicular, ovary and 
 hepatic substance. Also to be considered are the 
 brain, spinal cord and calcium salts. 
 
 Dose. 1/20 to 1/10 grain two to three times a 
 day between meals. Tablets of 1/20 grain. 
 
 PINEAL GLAND 
 
 Source and Parts Used. The pineal body is ob- 
 tained from young cattle. The total gland is used. 
 This gland is exceedingly small, requiring approx- 
 imately five thousand to make one pound of the 
 extract. The gland is desiccated and triturated. 
 
 Anatomy and Physiology. The pineal gland is 
 a small, reddish body situated beneath and back of 
 the corpus callosum and rests on the corpora quad- 
 rigemina. The central substance consists of. white 
 and gray matter. The blood vessels are small and 
 form a delicate capillary plexus. The function of 
 this gland has not been well established and is 
 really in the experimental stage. The gland is 
 known, however, to have a definite physiological 
 action in youth. Disordered function in this gland 
 produces a marked change in metabolism and ma- 
 turity. 
 
ORGANOTHERAPY 43 
 
 Therapeutic Indication. This gland has been 
 used clinically in the treatment of mentally deficient 
 children and in cases where there is evidence of 
 defective mentality. In early life this gland seems 
 to have an influence over nutrition and develop- 
 ment of the genital organs. It seems, also, to have 
 some effect on the development of the nervous sys- 
 tem. Extract of this gland may act favorably in 
 chronic functional brain diseases, lack of cerebral 
 nutrition, chronic softening, mania and dementia. 
 
 Counter-indicated. This product is apparently 
 non-toxic and seems to be of little use when given 
 to children over twelve years of age. 
 
 Dose. 1/10 grain, three times a day, between 
 meals. To be persisted in for some five or six 
 months. Tablets of 1/10 grain. 
 
 PITUITARY BODY 
 
 Source and Parts Used. This gland is obtained 
 from cattle. The parts used are the whole gland, 
 posterior lobe and anterior lobe. One part of the 
 whole gland and the posterior lobe each represents 
 about four and one-half parts of the fresh sub- 
 stance. One part of the anterior represents about 
 five parts of the fresh gland. 
 
 Anatomy and Physiology. The pituitary body, 
 consisting of two lobes and weighing from five to 
 
44 TREATISE ON 
 
 ten grains, is a small, reddish-gray body, occupying 
 the Stella turcica of the sphenoid bone. The 
 smaller or posterior lobe consists of nervous tissue, 
 and the anterior lobe, the larger of the two, resem- 
 bles the structure of the thyroid. The vesicles are 
 enclosed by a connective tissue rich in capillaries. 
 These two distinct parts apparently have separate 
 actions, as the posterior lobe can be removed with- 
 out much effect, while the opposite is true of the 
 anterior. The posterior lobe contains an extremely 
 active substance, which stimulates the un-striped 
 muscular fibers. This is very marked on the preg- 
 nant uterus. It also stimulates mammary activity 
 and renal secretion and favors carbohydrate 
 metabolism. 
 
 Therapeutic Indication — Posterior Lobe. This 
 product is given to hasten labor after the second 
 stage has commenced. The using of this product 
 in these cases should be done with great care, as 
 much damage might result, if precaution is not 
 taken. Owing to its action on the heart muscle, it 
 might be useful in shock, cardiac weakness and 
 heart failure. It also increases blood pressure, 
 when given for some time. It is a marked diuretic 
 and has been used in uremia and dropsy, although 
 great care should be exercised in giving this prod- 
 uct in uremia. Owing to the action of this product 
 on the intestinal tract, it is found useful in meteor- 
 ism, especially following laparotomy. It is useful 
 
ORGANOTHERAPY 45 
 
 in acute intestinal stoppage and is also important in 
 hyperthyroidism, where it is necessary to support 
 the heart. This product is useful in uterine involu- 
 tion and controlling hemorrhages. It has been used 
 with success in threatened mammary abscess and 
 in bronchial asthma when used in conjunction with 
 adrenalin. Enuresis of children has been benefited 
 by this product. 
 
 Principal Indications Pituitary Posterior. Gen- 
 eral stimulant upon the un-striped muscular fibres, 
 especially marked on the pregnant uterus and is 
 USED with CARE in the second stage of labor. 
 
 Counter-indicated. This product should never 
 be given in early stage of labor, as its action might 
 cause rupture of the uterus. Neither should it be 
 used in hypertension or in severe acute nephritis. 
 
 Synergistics. Adrenalin. 
 
 Dose. One-quarter to one grain, three to four 
 times per day. Tablets of one-quarter grain. 
 
 PITUITARY BODY ANTERIOR LOBE 
 
 Therapeutic Indication. Delayed mental de- 
 velopment in children, amenorrhea of girls and 
 young women, asexual individuals, infantilism and 
 bronchial asthma. 
 
 Principal Indications Pituitary Anterior. In- 
 fantilism, delayed mental development in children, 
 amenorrhea, especially in the obese. 
 
46 TREATISE ON 
 
 Synergistics. Thyroid gonads. 
 Dose. One to four grains, three to four times 
 per day, between meals. Tablets of one grain. 
 
 PITUITARY BODY WHOLE GLAND 
 
 Therapeutic Indication. To control definite 
 symptoms of pituitary diseases, neuralgic pain, 
 lethargy and infantilism. It is said to be of some 
 benefit in Addison's disease. It is used, combined 
 with adrenalin, in cases having low blood pressure, 
 as found in tuberculosis, malnutrition and typhoid 
 fever. It is of benefit in relieving tachycardia. 
 This product also stimulates digestion and alimen- 
 tary peristalsis and is of service in so-called "gen- 
 eral rundown condition. " This product is said to be 
 of benefit in the treatment of cancerous conditions. 
 
 Principal Indications Pituitary Whole. Lack 
 of systemic tone, atony, gastrointestinal atony, low 
 blood pressure, malnutrition and hypopituitarism. 
 Is a stimulant to heart and blood vessels where they 
 lack power and stimulant to the un-striped muscular 
 fibers. 
 
 Synergistics. Thyroid, gonads, thymus. 
 
 Dose. One-half to one grain, between meals 
 and at bedtime. Tablets of one-half grain. 
 
ORGANOTHERAPY 47 
 
 PLACENTAL SUBSTANCE 
 
 Source and Parts Used. The placenta of sheep 
 and cows is that chiefly used. One part of the 
 desiccated parenchyma of the placenta represents 
 about six parts of the fresh gland. 
 
 Anatomy and Physiology. The mucous mem- 
 brane of the uterus, in the region where the pla- 
 centa is attached, becomes hollowed out by sinuses, 
 which connect on the one hand with arteries and 
 on the other with the veins of the uterus. There 
 is no direct communication between the blood ves- 
 sels of the mother and that of the fetus, but layers 
 of membrane intervene between, making a free 
 interchange of matter between them by diffusion 
 and osmosis. The normal placenta weighs approx- 
 imately four pounds. It has been quite well estab- 
 lished that the placenta has an internal hormone 
 secretion that favors lactation, uterine involution 
 and re-establishes normal conditions after child- 
 birth. 
 
 Therapeutic Indication. Extract of the paren- 
 chyma of the placenta is used to cause an increase 
 in the production of milk. This product has given 
 satisfaction in the treatment of fibroma and carci- 
 noma of uterus, menorrhagia, dysmenorrhea, en- 
 larged and sensitive uterus. It is recommended to 
 prevent atrophy of the generative organs after 
 ovariotomy, chronic metritis and infections after 
 labor. 
 
48 TREATISE ON 
 
 Synergistics. Mammary gland, pituitary total. 
 Dose. Three to nine grains, four times per 
 day, between meals. Tablets of three grains. 
 
 PROSTATE GLAND 
 
 Source and Parts Used. These glands are ob- 
 tained from cattle and horses. One part of the 
 desiccated gland represents about six parts of the 
 parenchyma of the prostate gland. 
 
 Anatomy and Physiology. The prostatic 
 gland, weighing between four and five drams, is 
 situated at the neck of the urinary bladder and 
 encloses the commencement of the urethra. It is 
 somewhat the shape of a chestnut and is about one 
 and one-half inches wide, one and one-quarter 
 inches long and one-half inch thick. It is composed 
 of compound tubular glands, embedded in muscu- 
 lar and connective tissue. 
 
 Therapeutic Indication. This extract has been 
 used in prostatic hypertrophy, prostatorrhea, reten- 
 tion of urine and neurasthenia of prostatic origin. 
 It has been used in the treatment of specific and 
 non-specific infection. The extract of the prostate 
 gland is not in general use. 
 
 Synergistics. Used in combination with testic- 
 ular extracts, lymphatic glands and thyroid. 
 
 Dose. Three to six grains, three times a day, 
 
ORGANOTHERAPY 49 
 
 between meals. Increased as desired. Tablets of 
 three grains. 
 
 SALIVARY GLANDS 
 
 Source and Parts Used. These glands are ob- 
 tained from cattle. One part of the desiccated gland 
 represents about fifteen to twenty per cent of the 
 fresh gland. 
 
 Anatomy and Physiology. There are three 
 pairs of glands, namely, the parotid, submaxillary 
 and sublingual. These glands are compound 
 tubular and made up of lobules with ducts 
 that empty into the main duct of the gland. 
 The lobules are connected by connective tissue. 
 They secrete a mucus of alkaline reaction and 
 convert starchy materials into sugar. These glands 
 evidently are glands of internal secretion, as evi- 
 denced from the effect displayed in cases of orchitis, 
 ovaritis and pancreatitis following mumps. 
 
 Therapeutic Indication. Parotid extract has 
 been used in the treatment of mumps and pelvic 
 disorders of women, as dysmenorrhea, ovaritis and 
 ovarian neuralgia, enlarged and tender ovaries, 
 chronic endometritis and subinvolution. It has also 
 been used successfully in irregular and painful men- 
 struation. These products are very little used, as 
 there are others that are more efficient in their 
 action. 
 
50 TREATISE ON 
 
 Synergistics. Parotid, ovary and mammary 
 substance. 
 
 Dose. Two to eight grains, four times a day, 
 between meals. Tablets of two grains. 
 
 SPLEEN 
 
 Source and Parts Used. The spleen is obtained 
 from calves, pigs and sheep. The total extract of 
 the parenchyma of the spleen is part used. One 
 part of the desiccated gland represents about five 
 parts of the fresh gland. 
 
 Anatomy and Physiology. The spleen, the 
 largest of the so-called vascular glands, weighs 
 approximately eight ounces and has no excretory 
 duct. It is of a deep reddish brown color and varies 
 in shape and also in size, becoming smaller in old 
 age. It is situated to the left of the stomach and 
 below the diaphragm. The vessels enter and leave 
 the gland at the hilus. This organ seems to be 
 concerned in the manufacture of the blood corpus- 
 cles and is said to act as a filter for the removal, 
 from the blood stream, of deteriorated white and 
 red corpuscles. It is quite possible that the spleen 
 has an influence upon digestion. One feature of the 
 chemical composition of the spleen is the presence 
 of a special proteid of the nature of alkali-albumin, 
 containing organic iron. The salts of the spleen 
 
ORGANOTHERAPY 51 
 
 consist chiefly of sodium phosphate. The spleen is 
 also the source of an active peristaltic hormone. 
 This product is apparently only stored in the spleen, 
 having been produced in the stomach and duo- 
 denum. 
 
 Therapeutic Indication. The total extract of 
 the spleen is used in cases of malnutrition, tubercu- 
 losis, anemia and chlorosis and in those cases where 
 there appears to be a deficiency in the iron, phos- 
 phorus and sodium. It is used, also, in tubercu- 
 losis of the bone and lymphatic glands, malarial 
 toxemia, spleen cirrhosis, inactivity or partial 
 paralysis of the intestinal tract and chronic con- 
 stipation. 
 
 Counter-indicated. In shock and vasomotor in- 
 stability. 
 
 Synergistics. Thyroid, liver, hemoglobin. 
 
 Dose. Five to fifteen grains, three to four 
 times a day, after meals. Tablets of five grains. 
 
 STOMACH 
 
 Source and Parts Used. The mucous mem- 
 brane of the hog's stomach, that has been excited 
 to digestive action, is the part used. The normal 
 digestive elements are pepsin and hydrochloric 
 acid. Gastrin is obtained by scraping the mucus 
 from the pyloric part of the hog's stomach. 
 
52 TREATISE ON 
 
 Anatomy and Physiology. The stomach is a 
 pear-shaped dilation of the alimentary canal, con- 
 necting the esophagus and duodenum and lying 
 transversely across the upper part of the abdomen 
 and below the diaphragm. It consists of four coats, 
 serous, muscular, submucous and mucous, weighs 
 from four to five ounces and has a capacity of from 
 five to eight pints. Normal gastric juice converts 
 proteids into peptones. The average amount of 
 gastric juice secreted every twenty-four hours is 
 from ten to twenty pints. The amount of hydro- 
 chloric acid varies from two to two-tenths per cent. 
 The chief power of digestion of the gastric juices 
 depends on the pepsin and hydrochloric acid. The 
 general effect of stomach digestion is the conver- 
 sion of food into chyme. 
 
 Therapeutic Indication. Principal indications 
 are gastric indigestion, dyspepsia and acute con- 
 ditions, where there is a disturbance of gastric 
 digestion, requiring the assistance of digestive 
 ferments. These products are also frequently given 
 with indicated medication in gastric conditions. 
 
 Synergistics. Hydrochloric acid, papain and 
 stomachic. 
 
 Dose. Two to five grains after meals. Best 
 given in solution with hydrochloric acid. 
 
ORGANOTHERAPY 53 
 
 TESTICLES 
 
 Source and Parts Used. Testicles of rams and 
 bulls are most suitable for producing the active 
 therapeutic properties. One part of the desiccated 
 substance represents about seven of the fresh gland, 
 depending on the age of the animal. 
 
 Anatomy and Physiology. The gland weighs 
 from six to eight drachms. Orchic extract, pre- 
 pared from this gland, contains at least four active 
 principles — viz. phosphorized albumin, lecithin 
 (phosphorized fats), spermin and nuclein. The 
 first two are of value as nerve constructives, the 
 third is said to increase the oxygen-carrying power 
 of the corpuscles and the fourth possesses bacteri- 
 cidal properties. The chief chemical elements are 
 associated with nutrition, oxidation and cell activity 
 in general. The cells of Leydig are supposed to be 
 the seat of the formation of the internal secretion 
 of the testes. At puberty there is a great develop- 
 ment of these cells and a marked atrophy of same 
 cells at old age. 
 
 Therapeutic Indication. Principal indications 
 of orchic substance are infantilism, congenital mal- 
 formation, sterility, premature senility, impotence 
 and testicular insufficiency and debility, melan- 
 cholia, neurasthenia, defective oxidation, defective 
 growth and mentality. Good results have been 
 obtained by the use of this product in amenorrhea 
 
54 TREATISE ON 
 
 and treatment of the menopause. This product 
 has been used with benefit in diabetes and tubercu- 
 losis. 
 
 Synergistics. Small doses of thyroid, prostate, 
 lymphatic glands, adrenal glands and the usual drug 
 medication. 
 
 Dose. Two to ten grains, four times per day. 
 Dose to be increased, as required, over an extended 
 period of time. Tablets of two grains. 
 
 THYMUS GLAND 
 
 Source and Parts Used. The thymus gland is 
 obtained from cattle and sheep, preferably the 
 fetal animal. The total gland is used. One part 
 of the desiccated gland represents about six parts 
 of the fresh gland. 
 
 Anatomy and Physiology. This gland, consist- 
 ing of two lobes, is situated in front of the trachea 
 and over the top of the sternum and weighs, 
 normally, about 75 grains. Development of this 
 gland takes place in the fetus and early childhood 
 and reaches its height of development about the 
 age of two years. It then gradually diminishes in 
 size until, in adult life, but a small vestige remains. 
 The thymus gland has a decided influence upon the 
 metabolism of mineral salts, especially lime, and 
 
ORGANOTHERAPY 55 
 
 also regulates the phosphorus. It appears, also, 
 to regulate the growth and activities of the sexual 
 organs in childhood and seems to have an influence 
 upon the ossification of the bones. 
 
 Therapeutic Indication. The extract of this 
 gland has been used in a variety of diseases, as 
 cretinism, deficient development, exophthalmic 
 goiter, chlorosis, rickets, delayed union of fractures, 
 arthritis, malnutrition and deficient growth. It has 
 also proven of benefit in anemia, pernicious anemia, 
 lymphatic disorders and Grave's disease. The 
 thymus extract has exceeded all other therapeutic 
 preparations. It is especially rich in nuclein, which 
 possesses a large proportion of organic phosphorus. 
 
 Nuclein is a proteid substance possessing phos- 
 phorus in the form of Nucleinic Acid. Nucleins, 
 the chief chemical constituents of cell nuclei, are 
 found in both animal and vegetable tissues. 
 Wherever there is a nucleus there is found nuclein. 
 Nuclein is generally insoluble in dilute acids, but 
 soluble in dilute alkalies and resists peptic diges- 
 tion. It has four principal functions, to serve as a 
 natural antiseptic, to destroy toxic products which 
 accumulate through faulty elimination, to act as a 
 natural bactericide and to resist microbe invasion. 
 This product is obtained from yeast cells and from 
 a number of the endocrine glands and animal 
 tissues, as the thymus, thyroid, liver and spleen. The 
 giving of nuclein causes no functional disturbance, 
 
56 TREATISE ON 
 
 but does cause a marked increase of the leucocytes 
 in both healthy and unhealthy subjects. Nuclein 
 has been therapeutically employed in the treatment 
 of infectious diseases such as pneumonia, typhoid 
 fever, tuberculosis, rickets, erysipelas and kindred 
 troubles. This product has been found of benefit, 
 also, in the treatment of dementia perecox and gen- 
 eral paresis. Nuclein medication is prompt and 
 permanent. 
 
 Dose. One-half to two grains, to be increased, 
 if required. 
 
 Principal Indications. Delayed development in 
 children and cases where there is disturbance of 
 the mineral metabolism, malnutrition, exophthal- 
 mic goiter, acute and chronic infectious diseases, 
 especially the chronic of an asthenic type, as tuber- 
 culosis and anemia. 
 
 Counter-indicated. Thymus product should be 
 given with care in uric acid diathesis, rheumatic 
 and gouty conditions. 
 
 Synergistics. Calcium salts in tubercular or 
 lymphatic diseases. Anterior pituitary gland in 
 Grave's disease, thyroid and gonads. 
 
 Dose. Three to six grains of desiccated gland 
 four to five times per day, about one hour after 
 meals. To be increased as indicated. Tablets of 
 three grains. 
 
ORGANOTHERAPY 57 
 
 THYROID GLAND 
 
 Source and Parts Used. The animals from 
 which the thyroid glands are obtained are, princi- 
 pally, lambs and sheep. The glands, freed of their 
 connective tissue and all fat, are desiccated, pow- 
 dered and standardized to contain approximately 
 .2 per cent of actual iodine. One part of the dried 
 substance represents about six parts of the fresh 
 gland. 
 
 Anatomy and Physiology. The thyroid gland, 
 weighing from one to two ounces, is the most im- 
 portant of the ductless glands and its therapeutic 
 efficiency has been thoroughly proven. It is 
 situated in the neck at the upper portion and in 
 front of the trachea and consists of two lobes, 
 situated one on each side of the trachea and con- 
 nected by a band called the isthmus. The gland, 
 which is surrounded by a capsule, is composed of 
 vesicles lined with cylindrical cells, embedded in 
 fat and connective tissue. The vesicles contain a 
 viscid yellowish fluid, the chemical constituents of 
 thyroid extract, and include iodothyrin, which is 
 its active principle. Iodothyrin contains organic 
 iodine, nitrogen, sulphur and phosphorus. This 
 gland is larger in the female than in the male. It 
 is known to become enlarged during excitement or 
 emotional strain and is one of the chief detoxicating 
 agents of the body. Upon removal of the thyroid 
 
58 TREATISE ON 
 
 tetany sets in and the animal dies of cachexia. It 
 is found that the thyroid gland is concerned with 
 calcium metabolism. With a lack of thyroid secre- 
 tion, there is a lack of the calcium. With excess 
 thyroid secretion, there is an increase of the cal- 
 cium leaving the body. Human beings who have 
 a deficient thyroid secretion are susceptible to cold 
 and suffer increased discomfort during the winter. 
 The opposite is true of individuals with the hyper- 
 secretion of the thyroid, as in Grave's disease, 
 where they do not suffer inconvenience from cold 
 weather, but feel the heat of summer very per- 
 ceptibly. It is a well-known fact that these indi- 
 viduals suffer very much from nervousness and 
 restlessness and are subject to rapid loss of flesh, 
 which in some cases reaches actual emaciation. 
 
 Therapeutic Indication. The history of thyroid 
 therapy is fairly well established, as it has been 
 successfully used in the treatment of parenchym- 
 atous goiter showing deficient thyroid secretion 
 of the proper hormones. In congenital absence or 
 pathological destruction of the thyroid gland, there 
 are defective secretive conditions. These condi- 
 tions are very pronounced in myxedema, cretinism, 
 infantilism, certain mental disorders and forms of 
 insanity, obesity and anemia. This product is rec- 
 ommended in certain symptoms of insanity, includ- 
 ing hysteria, melancholia, dementia and other 
 peculiarities associated with thyroid disorders that 
 
ORGANOTHERAPY 59 
 
 very often accompany the menopause. This 
 product is often found of benefit in the treat- 
 ment of rheumatic conditions, arthritis, migraine, 
 arterio-sclerosis, defective oxidation, malnutrition 
 and defective circulatory conditions. Thyroid 
 extract has been used with success in irregular 
 hemorrhages of the menopause, uterine fibroids, 
 rickets, progressive muscular atrophy and in- 
 somnia. This product is recommended in the 
 treatment of dysmenorrhea, amenorrhea and 
 chlorosis. Acromegaly has yielded to the com- 
 bined treatment of thyroid extract and pituitary 
 gland substance. Tetany, torticollis and epilepsy 
 are found to be benefited by this combination. 
 
 Principal Indication. Temperature, tendency 
 to subnormal, 97 to 98 degrees Fahrenheit, patient 
 feels cold. Headaches, usually frontal or occipital, 
 tendency to rhinitis. Teeth easily become carious, 
 soft, subject to pyorrhea. Tonsils usually enlarged 
 and subject to slight and severe attacks. Patient sub- 
 ject to colds, in winter to bronchitis. Poor circula- 
 tion, pulse rather slow, about 60 to 65. Patient's 
 appetite not large, many times craves sweets, sub- 
 ject to gaseous eructations after meals. There is 
 a relaxation of ligaments, crackling noise on motion 
 of small joints. Sudden increase of weight without 
 obvious reasons, one might suspect thyroid dis- 
 turbance, showing poor oxidation. Skin is dry, 
 rough, eczematous condition, sometimes intense 
 
60 TREATISE ON 
 
 itching. Hair usually coarse and dry, lacks luster, 
 tendency to come out, scarcity of hair in eyebrows. 
 Constipation is nearly always present. These sub- 
 jects are prone to fatigue and may present the 
 appearance of senility. Small doses of thyroid, 
 given at intervals in elderly persons, may be found 
 of benefit to help keep the arteries soft in those 
 cases where poor oxidation is in evidence. 
 
 Thyroid product is found of benefit in hypothy- 
 roidism, myxedema, cretinism, obesity, arterio- 
 sclerosis with low blood pressure, malnutrition, 
 rheumatism and arthritis. 
 
 You will note hyperthyroidism presents the 
 opposite line of symptoms, in which case thyroid 
 extract should not be given. 
 
 Counter-indicated. Thyroid extract is counter- 
 indicated in the majority of cases involving hyper- 
 thyroidism, Grave's disease, excessive circulatory 
 disturbance, palpitation and shortness of breath. 
 The symptoms underlying these troubles are 
 caused by an excess of thyroid secretion and the 
 giving of thyroid extract would increase the 
 severity of the trouble. 
 
 Synergistics. Thyroid extract in small doses 
 has proven to be of much therapeutic value in com- 
 bination with other glandular extracts. Iodides 
 frequently enhance its therapeutic efficiency. 
 
 Dose. It has been proven that this product has 
 been given in too large doses. Overdoses will be 
 
ORGANOTHERAPY 61 
 
 followed by more or less irritability of the nervous 
 and circulatory system producing tachycardia, 
 insomnia, headache, dizziness and pains in the back 
 and limbs. When these symptoms occur this pro- 
 duct should be withdrawn. One quarter of a grain 
 is quite sufficient to start with. Dose to be in- 
 creased, if conditions permit and it is required. 
 Tablets of one-fourth grain. 
 
 TONSIL 
 
 Source and Parts Used. Tonsils of calves and 
 other young animals are used. Total extract of the 
 gland. No preparation of this product is on the 
 market. 
 
 Anatomy and Physiology. The tonsils, two in 
 number, consisting of glandular tissue, are situated 
 between the anterior and posterior arches of the 
 soft palate. Each has from fifteen to twenty open- 
 ings. The tonsil is bound by a fibrous capsule. 
 There is a mucous secretion from the tonsil which 
 serves to lubricate and moisten the throat. 
 
 Therapeutic Indication. It has been said that 
 the tonsils are the most active of the organic ex- 
 tracts. The desiccated powder of this gland is said 
 to increase both red and white corpuscles and 
 reduce blood pressure. Said to be of service in 
 treatment of diabetes and anemia. The extract 
 
62 TREATISE ON 
 
 of this gland has not been demonstrated, as to its 
 true clinical therapeutics. 
 
 Dose. This depends upon age of animal. 
 Clinical work has not as yet established the dose 
 for this extract. 
 
 UTERINE EXTRACT 
 
 An extract made from the substance of the 
 uterus has been employed in disorders and condi- 
 tions which follow as a consequence of the re- 
 moval of the uterus and its appendages. There 
 is not sufficient data to enable any conclusion to 
 be formed as to the efficiency of this extract, there- 
 fore more knowledge must be acquired before we 
 shall be able to give the true therapeutics. 
 
ORGANOTHERAPY 63 
 
 ADRENAL OVARIAN PANCREAS 
 COMPOUND 
 
 Adrenal (Total) gr. J4 
 
 Pituitary (Total) gr. y 2 
 
 Ovarian Substance gr. \y 2 
 
 Pancreas (Total) gr. 3 
 
 Indicated. Nervousness and irritable condi- 
 tions due to hypersecretion of the thyroid. Dis- 
 turbed and irritable condition of the circulatory 
 organs. Irregular heart, rapid and weak pulse. 
 This product will be found of benefit in overcoming 
 disturbed conditions due to ovarian troubles. It 
 acts as a sedative to the sympathetic system. 
 
 Dose. One tablet four times a day, one to two 
 hours before meals. Would suggest the giving of 
 spermin extract, from y 2 to 1 grain, in combination 
 with this formula for men, when indicated as 
 stated above. 
 
 ADRENAL PITUITARY COMPOUND 
 
 Adrenal (Total) gr. */ 2 
 
 Pituitary (Anterior Lobe) . . . .gr. 1^2 
 Sodium, Calcium, Potassium 
 
 Compound gr. 3 
 
 Indicated. Bronchial asthma and spasmodic 
 conditions of the pulmonary tract. In conjunction 
 
64 TREATISE ON 
 
 with the giving of the above product antispas- 
 modics, no doubt, will be in order for immediate 
 relief, afterward continuing the above formula for 
 some time. 
 
 Dose. One tablet four to five times a day, as 
 indicated. 
 
 ADRENAL AND SECRETIN COMPOUND 
 
 Adrenal Substance (Total) . . . .gr. J4 
 
 Secretin (Duodenal) gr. 2 
 
 Bile Salts gr. 2 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 6 
 
 Indicated. Chronic indigestion, associated with 
 pancreatic and biliary inactivity, constipation, clay- 
 colored stools, hypochlorhydria, fermentation of 
 food in intestinal tract and toxemia. This combina- 
 tion stimulates the digestive secretions and assists 
 assimilation. 
 
 Dose. One to two tablets two hours after eat- 
 ing, to be increased as conditions require and to be 
 given, in chronic cases, over an extended period. 
 
ORGANOTHERAPY 65 
 
 ADRENAL THYROID SPERMIN 
 COMPOUND 
 
 Adrenal Substance (Total) gr. J4 
 
 Thyroid Gland gr. 1/10 
 
 Spermin Extract gr. 1 
 
 Lecithin gr. 1 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 5 
 
 Indicated. In a general run down condition, as 
 follows acute infectious diseases, chronic asthenic 
 conditions, fatigue, low blood pressure and lowered 
 vitality. This product should be given over an 
 extended period. 
 
 Dose. One tablet four times a day. Increased 
 blood pressure is a guide to the giving of this tablet. 
 
 ADRENAL THYROID SPLEEN COMPOUND 
 
 Adrenal Gland (Total) gr. J4 
 
 Spermin gr. 2 
 
 Thyroid gr. 1/20 
 
 Spleen Substance gr. 3 
 
 Indicated. In tuberculosis and as a tonic where 
 nutrition has been greatly interfered with, as evi- 
 denced by loss of flesh and muscular energy. This 
 condition is found in cases of tuberculosis, malaria 
 and other wasting diseases. 
 
 Dose. One tablet after meals and at bedtime. 
 
 5 
 
m TREATISE ON 
 
 HEMOGLOBIN, NUCLEIN COMPOUND 
 
 Hemoglobin gr. 3 J^ 
 
 Spleen (Total) gr. \y 2 
 
 Nuclein gr. y 2 
 
 Sodium, Calcium, Potassium 
 
 Compound gr. y 2 
 
 Indicated. Anemia, pernicious anemia, cachexia 
 and in other conditions, where a ferruginous tonic 
 is indicated. Hemoglobin (organic iron) is the 
 most easily assimilable of any iron combination 
 and is not constipating. 
 
 Dose. One tablet after meals and at bedtime. 
 More often if required. 
 
 HEPATIC AND BILE SALTS COMPOUND 
 
 Hepatic Substance gr. 2y 2 
 
 Bile Salts gr. 3 J4 
 
 Indicated. Chronic hepatic troubles, as cirrho- 
 sis and hypertrophy. Stimulates flow of bile, 
 promotes intestinal digestion, relieves intestinal 
 fermentation and constipation. This combination 
 will be found of benefit in functional hepatic 
 troubles and gall stones. 
 
 Dose. One tablet before meals and at bedtime. 
 If constipation is pronounced, increasing doses 
 should be given, until results are obtained. Then 
 lessen doses and give over an extended period. 
 
ORGANOTHERAPY 67 
 
 HEPATIC, BILE AND PANCREATIN 
 COMPOUND 
 
 Hepatic Substance gr. 2^4 
 
 Bile Salts gr. 2 
 
 Pancreatin gr. \y 2 
 
 Indicated. Intestinal indigestion with liver in- 
 activity, toxemia and alimentary stasis. 
 
 Dose. One to two tablets two hours after 
 meals, as required. 
 
 HEPATIC, SPLEEN AND ADRENAL 
 COMPOUND 
 
 Hepatic Parenchyma gr. 2 
 
 Spleen Substance gr. 2 
 
 Bile Salts gr. y A 
 
 Adrenal Substance (Total) . . . .gr. *4 
 
 Indicated. Hepatic and intestinal inactivity, 
 which in the majority of cases depend upon the 
 sluggish condition of the liver and malnutrition fol- 
 lowing the toxic conditions from liver inactivity. 
 
 Dose. One tablet four times a day, as required, 
 and over an extended period in chronic conditions. 
 
68 TREATISE ON 
 
 KIDNEY, PANCREAS COMPOUND 
 
 Kidney Desiccated 
 
 (Nephritin) gr. 3 
 
 Pancreas (Total) . . gr. 2 
 
 Indicated. In deficient renal activity, acute or 
 chronic nephritis (Bright's disease), uremia, 
 eclampsia and albuminuria of pregnancy. By the 
 giving of this product in edema and ascites due 
 to, or partly due to, nephritis, there should be a 
 reduction of these conditions, as I believe this pro- 
 duct has diuretic properties, owing to its action on 
 the tubules of the kidney. There is also a lessening 
 of the albumin passing and an increase of chlorides. 
 Kidney substance given in these troubles lowers the 
 nitrogen — that has been retained in the blood — and 
 will be found of benefit in rheumatic conditions, due 
 to this cause. Pancreas tends to neutralize adrenal 
 irritability and will be found of benefit in this 
 product. 
 
 Dose. One tablet to be given four times a day, 
 between meals. Increased as required. Strict at- 
 tention should be given to the diet, bowels and 
 skin. Hygiene also must be regarded. Proper rest 
 and other conditions, as high blood pressure and 
 arterio-sclerosis, must be considered by the physi- 
 cian. Treatment with this product should be given 
 as soon as nephritis is discerned. Would suggest 
 the giving of thyroid extracts, grs. }i to %, in con- 
 
ORGANOTHERAPY 69 
 
 junction with this formula, where high blood 
 pressure or hyperthyroidism is not a complication. 
 
 LECITHIN, NUCLEIN, HEMOGLOBIN 
 COMPOUND 
 
 Lecithin (90 to 95%) gr. 2 
 
 Nuclein gr. 1 
 
 Hemoglobin gr. 2 
 
 Sodium, Calcium, Potassium 
 
 Compound gr. 2 
 
 Indicated. As a reconstructive tonic to the 
 nervous system, especially in chronic nervous dis- 
 orders and malnutrition. The organic phosphorus 
 and iron as contained in this formula are easily 
 assimilable. 
 
 Dose. One tablet four times a day, after meals. 
 
 LYMPHATIC, SPLEEN AND THYROID 
 COMPOUND 
 
 Lymphatic Glands gr. 2 
 
 Spleen Substance gr. 2 
 
 Thyroid Gland gr. 1/20 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 6 
 
 Indicated. Lymphatic enlargement, lack of 
 thyroid secretion (hypothyroidism), anemia in 
 
70 TREATISE ON 
 
 children and adults and in cases having a tendency 
 to hemorrhage. 
 
 Dose. One to two tablets three to four times 
 a day, with food. 
 
 MAMMARY AND PITUITARY COMPOUND 
 
 Mammary Substance gr. 3 
 
 Pituitary (Total) gr. 1/3 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 5 
 
 Indicated. In functional or organic menstrual 
 disorders, menorrhagia, metrorrhagia, excessive or 
 prolonged menstrual flow, excessive climacteric 
 hemorrhages and uterine hemorrhages due to 
 fibroid or cancerous condition. 
 
 Dose. One tablet every three to four hours. 
 Ergotin should be given with this formula, as in- 
 dicated, and discontinued when not required, still 
 continuing the above formula, as is needed. 
 
 MAMMARY, PITUITARY AND PLACENTAL 
 COMPOUND 
 
 Mammary Substance gr. \ l / 2 
 
 Pituitary (Total) gr. y 2 
 
 Placenta Desiccated gr. 2 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 6 
 
ORGANOTHERAPY 71 
 
 Indicated. Galactagogue, mammary stimulant, 
 increasing the supply and nourishing quality of 
 milk in nursing mothers. Favors uterine in- 
 volution. 
 
 Dose. One to two tablets after meals and at 
 bedtime, to be increased as required. 
 
 NUCLEIN, SPERMIN, HEMOGLOBIN 
 COMPOUND 
 
 Nuclein gr. 
 
 Lecithin (95%) gr. 1 
 
 Spermin gr. 1 
 
 Hemoglobin gr. 2^4 
 
 Indicated. Organic iron and phosphorus in 
 combination that is easily assimilated and does not 
 constipate the patient. This product will be found 
 of benefit in cases of anemia, malnutrition and 
 where there is a need to increase both the white 
 and red blood corpuscles, giving the patient a bet- 
 ter stability of health. 
 
 Dose. One to two tablets one hour after meals 
 and at bedtime, as indicated. 
 
72 TREATISE ON 
 
 PANCREAS, THYROID, GONADS 
 COMPOUND 
 
 Pancreas (Total) gr. 2 
 
 Thyroid Gland gr. 1/16 
 
 Gonads A. A. gr. \y 2 
 
 Sodium, Calcium, Potassium 
 
 Compound , q. s. gr. 5 
 
 Indicated. In high blood pressure of male or 
 female, the cause not being entirely due to renal 
 or circulatory troubles. There is a stimulating ef- 
 fect of oxidation and cell activity. 
 
 Dose. One tablet after meals and at bedtime. 
 
 PANCREAS, TRYPSIN COMPOUND 
 (DIABETES) 
 
 Pancreas gr. 2y 2 
 
 Trypsin gr. 2 
 
 Amylopsin gr. J / 2 
 
 Indicated. In defective carbohydrate metabo- 
 lism, glycosuria, diabetes mellitus of pancreas 
 origin. Medicinal products may be given as in- 
 dicated. Care should be used in giving prepara- 
 tions of arsenic, where the condition is complicated 
 with albuminuria. However, these products will 
 be found of much value, when indicated. Before 
 treatment is begun the system must be thoroughly 
 alkalized to obtain results, as the acid conditions, 
 
ORGANOTHERAPY 73 
 
 that are found in diabetic cases, must be overcome. 
 Would recommend the giving of tablets, sodium, 
 lime and potassium compound, one to two tablets 
 with water, one hour before meals and at bedtime. 
 Should constipation become annoying, use saline 
 laxatives. When the urine and feces show they 
 are alkaline the above treatment should be begun 
 and the alkalies should be given along gradually 
 to keep the acids from predominating. Have the 
 patient follow the strict diet and hygiene, as this 
 must be done to obtain results. It has been stated 
 that the dropping of a solution of adrenalin in the 
 eye of an animal from which the pancreas has been 
 removed causes dilation of the pupil, which action 
 does not occur in a normal animal. This test has 
 been used to diagnose pancreatic diabetes from 
 liver diabetes. 
 
 Dose. Two to six tablets, two hours after meals 
 and at bedtime. This treatment is to be given over 
 an extended period. 
 
 PARATHYROID, SPERMIN, BILE 
 COMPOUND 
 
 Parathyroid Gland gr. 1/20 
 
 Spermin Extract gr. 1 
 
 Bile Salts gr. 2 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 5 
 
74 TREATISE ON 
 
 Indicated. When parathyroid glands require 
 stimulation and an added muscular tone, as in 
 paralysis, chorea, paralysis agitans, senility and 
 deficient oxidation. 
 
 Dose. One tablet four times a day. Increase 
 dose, as required. 
 
 PITUITARY, ADRENAL, LYMPHATIC 
 COMPOUND 
 
 Pituitary (Anterior Lobe) . . . .gr. Y\ 
 
 Adrenal (Cortex) . . . . gr. }i 
 
 Lymphatic Glands gr. 1 
 
 Lecithin gr. 1 
 
 Spermin gr. 1 
 
 Thyroid gr. 1/10 
 
 Indicated. Lowered vitality of the functional 
 organs, senility, neurasthenia. 
 
 Dose. One tablet three to four times a day. 
 
 PITUITARY ANTERIOR AND TOTAL 
 COMPOUND 
 
 Pituitary (Anterior Lobe) gr. 1 
 
 Pituitary (Total) gr. 1 
 
 Sodium, Calcium, Potassium 
 
 Compound gr. 3 
 
ORGANOTHERAPY 
 
 Indicated. Lack of development of the gonads, 
 infantilism and cases requiring increased cellular 
 activity. Stimulates metabolism. 
 
 Dose. One tablet four times a day. 
 
 PITUITARY THYMUS, THYROID 
 COMPOUND 
 
 Pituitary (Anterior Lobe) . . . .gr. 1 
 
 Thymus Gland gr. 1 
 
 Thyroid Gland gr. 1/16 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 6 
 
 Indicated. In children with defective mentality 
 and growth, backward children, those subject to 
 chorea, epilepsy, cretinism, anemia, lymphatic dis- 
 orders and blood dyscrasia. 
 
 Dose, One tablet two to three times a day, as 
 indicated, for a few months. 
 
 PROSTATE, SPERMIN, LYMPHATIC 
 COMPOUND 
 
 Prostate . gr. \y 2 
 
 Spermin gr. \y 2 
 
 Lymphatic gr. \y 2 
 
 Nuclein gr. % 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 6 
 
TREATISE ON 
 
 Indicated. Prostatic diseases, as enlarged 
 prostate, prostatic irritation, neurasthenic condi- 
 tions depending on prostatic troubles, lack of 
 gonad activity, senility, defective nutrition, im- 
 potency, neurasthenic conditions and mental 
 diseases. This product will be found of benefit 
 in the treatment of women who are of a neuras- 
 thenic tendency. 
 
 Dose. One tablet three to four times a day. 
 This product should be given for some time. In- 
 dicated medication may be used in conjunction, if 
 desired. 
 
 SODIUM, CALCIUM, POTASSIUM COM- 
 POUND (ALKALINE TABLET) 
 
 Sodium Phosphate pts. 2 
 
 Calcium Phosphate pts. 4 
 
 Calcium Glycerophosphate . . . .pts. 2 
 
 Magnesium Phosphate pts. 1 
 
 Potassium Bicarbonate pts. 16 
 
 Sodium Bicarbonate pts. 25 
 
 Indicated. As an antacid which aids in neu- 
 tralizing the excessive tendency of the body to acid, 
 (acidosis), which tendency is most common in 
 cases associated with endocrine insufficiencies. This 
 product is useful in toxic conditions that are due to 
 
ORGANOTHERAPY 77 
 
 alkaline deficiency. There should be a thorough 
 alkaline condition of the body established, in con- 
 junction with glandular extract treatment, as this 
 formula represents approximately, with the excep- 
 tion of sodium chloride, the proportions of mineral 
 salts present in the blood under normal conditions. 
 It is therefore indicated to overcome this acid 
 condition that has been due to poor oxidation and 
 to re-establish these alkaline mineral requirements 
 of the blood and tissues. Acids are the weapons 
 of death, while the alkalies are the foes of death. 
 
 Dose. One to two tablets dissolved in plenty 
 of water, one to two hours before meals and at bed- 
 time. This treatment should be continued for a 
 few weeks, to overcome the acid condition. 
 
 SPERMIN, THYROID COMPOUND 
 
 Spermin . . . . . . . gr. 2y 2 
 
 Thyroid gr. 1/20 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 5 
 
 Indicated. Impotency, enlarged prostate, sen- 
 ility, a general asthenic condition of the gonads. 
 
 Dose. One tablet four times a day, to be in- 
 creased if required and given over an extended 
 period. 
 
TREATISE ON 
 
 THYMUS, LYMPHATIC, PITUITARY 
 COMPOUND 
 
 Thymus Gland gr. 1 
 
 Lymphatic Glands gr. 2y 2 
 
 Pituitary (Anterior Lobe) . . . .gr. y 2 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 6 
 
 Indicated. In slow development of children, 
 especially those troubled with recurrent adenoids 
 and hypertrophied tonsils. This product assists in 
 reconstruction by supplying the needed hormones 
 of the endocrine glands. Alterative. 
 
 Dose. One tablet four times a day, as required. 
 
 THYMUS, THYROID, ADRENAL 
 COMPOUND 
 
 Thymus Gland gr. 1 
 
 Thyroid Gland gr. 1/10 
 
 Adrenal Gland (Total) gr. J4 
 
 Pituitary Gland (Anterior 
 
 Lobe) gr. y 2 
 
 Prostate Gland gr. \y 2 
 
 Orchic Substance gr. 2 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 6 T / 2 
 
 Indicated. Infantilism and endocrinous dis- 
 orders of the adult, treatment of children showing 
 
ORGANOTHERAPY 79 
 
 backward development, asthenia, hypochondriasis, 
 melancholia, functional and endocrine impotency, 
 sexual neurasthenia and sterility. 
 
 Dose. One tablet four times a day, to be in- 
 creased, as required and given over an extended 
 period. Indicated medications may be given, as 
 indications present themselves. 
 
 THYMUS, THYROID, PITUITARY 
 COMPOUND 
 
 Thymus Gland gr. 3 
 
 Thyroid Desiccated gr. j4 
 
 Pituitary (Total) gr. 1/20 
 
 Ovary gr. 1 
 
 Testes gr. 1 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 6 
 
 Indicated. In chronic rheumatism, arthritis 
 deformans and pains in joints. This product will be 
 found of service in myalgia, when there is poor 
 metabolism and elimination. 
 
 Dose. One tablet four times a day, to be given 
 for several weeks. Then treatment discontinued 
 for a time, to be begun again and given for some 
 time. Diet and hygiene must be observed. When 
 cases are complicated with low blood pressure, the 
 giving of the adrenal gland with the above formula 
 in doses of }£ to % grain will be of benefit. 
 
TREATISE ON 
 
 THYROID AND GONADS COMPOUND 
 
 Thyroid Desiccated gr. y$ 
 
 Ovary gr. 1 
 
 Testes gr, 1 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 5 
 
 Indicated. Neurasthenia, premature debility of 
 old age and asthenic conditions, menstrual disor- 
 ders and climacteric disturbances, suboxidation, in- 
 somnia and the headaches that are associated with 
 high blood pressure. Debilitated conditions, as 
 noted when patient lacks vigor, has a general run- 
 down condition and chronic cardiac disturbances, 
 with high blood pressure. 
 
 Dose. One to two tablets, three to four times 
 a day, one hour before meals, over an extended 
 period. 
 
 THYROID, NUCLEIN COMPOUND 
 
 Thyroid Gland gr. % 
 
 Nuclein gr. J4 
 
 Ferri Iodide Sacch gr. j4 
 
 Sodium, Calcium, Potassium 
 
 Compound gr. 5 
 
 Indicated. Goiter or enlargement of the thyroid 
 gland, due to a lack of thyroid secretion, as is noted 
 
ORGANOTHERAPY 81 
 
 in young girls at the age of puberty and women 
 during ovarian changes. These cases rarely pre- 
 sent the symptoms of anemia or malnutrition. 
 
 Dose. One tablet, three to four times a day, be- 
 tween meals. 
 
 THYROID, OVARIAN AND MAMMARY 
 COMPOUND 
 
 Thyroid (Total) gr. 1/10 
 
 Ovarian Substance gr. 1 
 
 Mammary Substance gr. 2j/£ 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 6 
 
 Indicated. Too frequent and prolonged men- 
 struation, dysmenorrhea, ovarian and pelvic con- 
 gestion, tender and irritable ovaries, menorrhagia, 
 metrorrhagia. Will be found of service at the cli- 
 macteric. 
 
 Dose. One tablet, three to four times a day, 
 beginning a week before menstruation and con- 
 tinuing during the flow. 
 
82 TREATISE ON 
 
 THYROID, PITUITARY AND GONADS 
 COMPOUND 
 
 Thyroid Desiccated gr. y& 
 
 Pituitary (Total Gland) gr. 1/20 
 
 Ovary gr. 1 
 
 Testes gr. 1 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 5 
 
 Indicated. Neurasthenia, premature debility of 
 old age and asthenic conditions, menstrual disor- 
 ders and climacteric disturbances, suboxidation, in- 
 somnia and the headaches that are associated with 
 low blood pressure. Debilitated conditions, as 
 noted when patient lacks vigor, has a general run- 
 down condition and chronic cardiac disturbances, 
 with low blood pressure. 
 
 Dose. One to two tablets, three to four times 
 a day, one hour before meals, over an extended 
 period. Suggest the giving of adrenal gland, grain 
 Yz to J4, when the patient has low blood pressure. 
 
ORGANOTHERAPY 83 
 
 THYROID, PITUITARY, PANCREAS COM- 
 POUND 
 
 Desiccated Thyroid (Whole 
 
 Body) gr. 1/25 
 
 Pituitary (Whole Body) gr. 1/50 
 
 Spleen Substance gr. 1 
 
 Pancreas gr. \y 2 
 
 Hepatic gr. 1 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 5 
 
 Indicated. To assist metabolism in wasting dis- 
 eases and conditions of malnutrition. This com- 
 bination will be found of benefit in cases where it 
 is found necessary to increase weight, as in tuber- 
 culosis and lowered vitality, as it tends to raise 
 body resistance to infection and aids normal diges- 
 tion. The giving of this combination can be rec- 
 ommended for undernourished children. Would 
 recommend the indicated medicinal tonics, where 
 required. 
 
 Dose. Two to four tablets, before eating and 
 at bedtime, as required. 
 
84 TREATISE ON 
 
 THYROID, PLACENTA COMPOUND 
 
 Thyroid Gland gr. 1/20 
 
 Placenta (Desiccated) gr. 4 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 6 
 
 Indicated. In vomiting and nausea of preg- 
 nancy. 
 
 Dose. One to two tablets, taken four to five 
 times a day, with as hot water as can be taken. 
 
 THYROID, SODIUM, CALCIUM, POTAS- 
 SIUM COMPOUND 
 
 Thyroid gr. y$ 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 5 
 
 Thyroid . gr. % 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 5 
 
 Thyroid gr. y 2 
 
 Sodium, Calcium, Potassium 
 
 Compound q. s. gr. 5 
 
 Indicated. Thyroid insufficiency, hypothyroid- 
 ism, myxedema and cretinism. These patients 
 generally run a subnormal temperature, have poor 
 circulation and slow pulse. The skin is dry and 
 rough, and may be eczematous, the nails are brittle 
 
ORGANOTHERAPY 85 
 
 and the teeth soft and subject to decay and the 
 hair turns prematurely gray. These patients are 
 nearly always constipated, require abundance of 
 sleep, are inclined to obesity and very prone to 
 fatigue and circulatory disturbances. They are 
 subject to migraine, asthmatic attacks, chronic 
 rheumatism, gout and mental symptoms. Thyroid 
 extract is given with the view of increasing the 
 cell chemistry and replacing the depleted alkaline 
 salts. 
 
 Dose. The patient should always be started 
 with a small dose, to be increased as conditions 
 warrant and can be tolerated. One tablet before 
 meals and at bedtime. 
 
 TRYPSIN, PANCREATIN AND PAPAIN 
 COMPOUND 
 
 Trypsin gr. y 2 
 
 Pancreatin gr. 2 
 
 Papain gr. 1 
 
 Berberine Muriate gr. 1/10 
 
 Jamaica Ginger gr. 1 
 
 Indicated. Gastro-intestinal indigestion, flatu- 
 lence and fermentation. Aids digestion of proteid 
 and starch. 
 
 Dose. One to two tablets, one hour and a half 
 after meals. 
 
INDEX 
 
 Adrenal Glands 15 
 
 Adrenal Cortex 16 
 
 Adrenal Medulla 16 
 
 Adrenal Total 16 
 
 Adrenal Ovarian Pancreas Compound 63 
 
 Adrenal Pituitary Compound 63 
 
 Adrenal and Secretin Compound 64 
 
 Adrenal Thyroid Spermin Compound 65 
 
 Adrenal Thyroid Spleen Compound 65 
 
 Antithyroid »*Serum 19 
 
 Appendix 18 
 
 Bile 27 
 
 Blood 19 
 
 Bone 21 
 
 Bone Medulla 22 
 
 Brain and Spinal Cord 22 
 
 Carotid Gland 24 
 
 Corpus Luteum 36 
 
 Duodenum (Secretin) 25 
 
 Hemoglobin 19 
 
 Hemoglobin Nuclein Compound 66 
 
 Hepatic and Bile Salts Compound 66 
 
 Hepatic Bile and Pancreatin Compound 67 
 
 Hepatic Spleen and Adrenal Compound 67 
 
 Kidneys (Nephritin) 26 
 
 Kidney Pancreas Compound 68 
 
 Lecithin Nuclein Hemoglobin Compound 69 
 
 Leucocyte Extract 19 
 
 87 
 
88 INDEX 
 
 Liver and Bile 27 
 
 Lungs 30 
 
 Lymphatic Glands 31 
 
 Lymphatic Spleen and Thyroid Compound 69 
 
 Mammary Glands 33 
 
 Mammary and Pituitary Compound 70 
 
 Mammary Pituitary and Placental Compound....... 70 
 
 Melanine 34 
 
 Nephritin 26 
 
 Normal Serum 19 
 
 Nuclein Spermin Hemoglobin Compound 71 
 
 Ovaries 34 
 
 Pancreas 39 
 
 Pancreas Thyroid Gonads Compound 72 
 
 Pancreas Trypsin Compound (Diabetes) 72 
 
 Parathyroid Gland 41 
 
 Parathyroid Spermin Bile Compound 73 
 
 Pineal Gland 42 
 
 Pituitary Body 43 
 
 Pituitary Body Anterior Lobe. 45 
 
 Pituitary Body Posterior Lobe 44 
 
 Pituitary Body Whole Gland 46 
 
 Pituitary Adrenal Lymphatic Compound 74 
 
 Pituitary Anterior and Total Compound 74 
 
 Pituitary Thymus Thyroid Compound 75 
 
 Placental Substance 47 
 
 Prostate Gland 48 
 
 Prostate Spermin Lymphatic Compound 75 
 
 Salivary Glands 49 
 
 Secretin 25 
 
 Sodium Calcium Potassium Compound (Acidosis) 76 
 
 Spermin Thyroid Compound 77 
 
INDEX 89 
 
 Spinal Cord 22 
 
 Spleen 50 
 
 Stomach 51 
 
 Testicles 53 
 
 Thymus Gland 54 
 
 Thymus Lymphatic Pituitary Compound 78 
 
 Thymus Thyroid Adrenal Compound 78 
 
 Thymus Thyroid Pituitary Compound 79 
 
 Thyroid Gland 57 
 
 Thyroid and Gonads Compound 80 
 
 Thyroid Nuclein Compound 80 
 
 Thyroid Ovarian and Mammary Compound 81 
 
 Thyroid Pituitary and Gonads Compound 82 
 
 Thyroid Pituitary Pancreas Compound 83 
 
 Thyroid Placenta Compound 84 
 
 Thyroid Sodium Calcium Potassium Compound 84 
 
 Tonsil 61 
 
 Trypsin Pancreatin and Papain Compound 85 
 
 Uterine Extract 62