■ 'Vi FIRST LINES I O F t PHYSIOLOGY, BY THE CELEBRATED Baron ALBERTUS HALLER, M. D. ^c. TRANSLATED FROM THE CORRECT LATIN EDITION Printed under the Inspection of WILLIAM C U L L E N, M. D. To which is added, A Translation of The Laborious INDEX compofed for that Edition. EDINBURGH: Printed for Charles Elliot, Parliament Square,’ M, D C C, L X X I X. t ADVERTISEMENT. T H E firft edition of this work was publifh- ed in 1747. It was defigned as a correc- tion and improvement of Boerhaave’s Inftitu- . dons, by adding the new difcoveries of Mor- gagni, Window, Albinus, Douglas, See. In 1751, another edition was publifhed; in which ibme things were treated more fully, and others more briefly, than before. The ana- tomical deferiptions, particularly, were here abridged ; fome new phyfiological difcoveries added j and a great number of typographical errors corrected. A THIRD edition was publilhed in 1 764. Here the. author conformed the order of his fubjects treated of in his Firft Lines to thofe of his larger work, and made the number of books contain- ed in both equal ; but did not think proper to abridge his Firft Lines any farther, left they fhould thus have become lefs fit for the pur- pofes of a text-book. The demand for this work foon became fo great, that an edition was printed at Edinburgh in 1766, under the infpedlion of the then Pro- feflTor of the Inftitutions of Medicine ; who had formed the phyfiological part of his ledlures upon a fimilar plan. The greateft care was taken to have this edition as exadl and free from typographical errors as poflible; and it was farther improved by the addition of an Index, [ vi ] Index, which may be confidered as an elegant compend of the whole. It was thought proper, however, to retain the erroneous numbers of the paragraphs which had efcaped in the original editions, for the more eafily referring from one place to another, and that no confulion might arife from tiling the different editions. Of the laft mentioned valuable edition tlie prefent is an exaeff tranllation, in which ail poffible care has been taken to give the tine meaning of the author, in a plain and eafy manner : An undertaking to wliich the publillier was incited by the conffderation, that the tranf- lation with which Undents have been hither- to furnilhed, not only was done from an old edition, exceedingly imperfect; in comparifon with the laft one; but is alfo unneceffarily ex- tended in the printing to double the fize of the original, and of courfe proportionably enhanced in the price. TABLE OP CONTENTS. Chap. Page. I. Of the animal fibres^ i II. Of the cellular fubjlance, 6 III. Of the arteries and veins^ 1 1 IV. Of the circulation of the blood, 26 V. Of the heart, 33 VI. Of the nature of the blood and juices of the human body, 62 VII. Of the common offices of the arteries, 7 1 VIII. Of the fecretions, 88 IX. Of refpiration, 108 X. Of the voice and fpeecb. 13^ XI. Of the brain and nerves, 146 XII. Of mufcular motion, 189 XIII. Of the fenfe of touch, 204 XIV. Of the tafte, 218 XV. Of fmelUng, 224 XVI. Of hearing, 248 XVII. Of the fight, 264 XVIII. Of the internal jenfes. 290 XIX. Of maflicationffaliva, and deglutition, 3 1 1 XX. Of the adion of the flomach on the food, 328 XXL Of the omentum, 345 XXII. Of the fpleen, 354 XXIII. Of the pancreas, 358 XXIV. Of the liver, gall-bladder, and bile, 361 XXV. Of the fmall inteflineS, 379 XXVI. Of the large inteflines, 390 XXVII. Of the chyliferous vejfels, 3 99 XXVIII. Of the kidneys, bladder, and urine, 405 XXIX. JDf the genital parts in man, 420 XXX. Of the virgin uterus, 435 XXXI. Of conception, 449 XXXII, Of nutrition, growth, life, and death, 487 FIRST Digitized by the Internet Archive in 2016 htt|is://archive.org/details/firstlinesofphys01hall FIRST LINES O F PHYSIOLOGY. CHAP. I. Of the Animal Fibres. I. HE moft fimple parts of the human body S are either fluid or folid. The fluid parts, ffi being of divers kinds, we Ihall hereafter M. confider in their moft convenient places. But here the folids, which make the moft Ample and true balls of the body, come firft to be confidered be- fore the hiftory of the other parts. 2. The yo/zV parts of animals and vegetables have this fabric in common, that their elements, or the fmalleft parts we can fee by the fineft microfcrope, are either fibres, or an unorganized concrete. g, A fibre in general may be confidered as re- fembling a line made of points, having a moderate breadth ; or rather as a flender cylinder. And tha£ the more conftant or permanent parts thereof are earth, is demonftratcd from a calcination, or a long continued putrefadtion. 4. Thefe earthy particles have their connexion and power of cohcfion, not from themfclves or a mere con-* B tadf, 2 ANIMAL FIBRES. Chap. I. ta£l, but from the intermediate glue placed betwixt them. This we know from the experiments mention- ed above (3.); and from the eafy experiment by which a burnt hair, whofe parts yet hang together, recovers a degree of firmnefs by dipping in water or oil. Alfo the remains of ivory or bone ihavings, whofe jelly has been extrafted, become friable, like bones which, by long expofure to the weather, are converted into a true earth very ready to imbibe water. But even bones rendered friable by having their gluten extracted, will recover their hardnefs when the gluten is redored. It is this gluten alone which holds together the more fimple parts of animals. 5. That this glue is compofed of oil combined with v/ater by the vital attrition in animals, appears again from the chemical analyfis of bones and hair ; from the jelly of bones, ivory, and horns ; and from the nature of our aliments themfelves. Nor is there any kind of glue that could more powerfully join the parts of animals together ; as we experience in fifii-glue, and that of joiners or cabinet-makers, &c. 6. Earthy particles then(g.) cohering longitudinally, and tied together by an intervening cohefive glue (5.'), com- pofe firfimne of the lead or mod fimple fibres, fuch as we have a knowledge of rather from reafon than fenfe. 7. But the fibres which appear fird to the fight arc of two kinds. The fird kind of thefe fibres is lineal ; namely, fuch as have their length confiderably large in proportion to their breadth ; and which, by difpofing ot the elementary particles in a right line, mud of courl'e lay them generally parallel with the contiguous fibres. Examples of fuch fibres we fee in the bones, and molt eafily in thofe of a foetus ; and likewife in the tendons, ligaments, and mufcles : only we mud always remem- ber, that the eye never reaches to the finalled fibres, but to larger ones made up of the fmalled, and like to them in dendernefs, placed together in a reidiliner-l courl'e. That thefe are not different from the fmalled fibres, we arc perfuaded by the mod accurate micro- fcope> Chap. I. ANIMAL FIBRES. 5 fcopes of Muyfe and Lewenhoeck ; by which the muf- cular fibres, divided even to the laft, appear fimilar to the larger, till at length they feem mere lines. 8. The fecond kind of fibres (7.) are thofe in which the breadth is frequently larger than their length. Thefe, when loofely interwoven with each other, are called the cellular tunic ; though the name tunic or membrane is on many accounts very improper. 9. This cellular fubftance is made up of an infinite number of little plates or fcales, which, by their va- rious direflions, intercept fmall cells and web-like fpaces j and join together all parts of the human body in fuch a manner, as not only fufiains, but allows them a free and ample motion at the fame time. But in this web-like fubfiance there is the greateft diverfity ,in refpedl of the proportion betwixt the folid parts and intercepted cells, as well as the breadth and ftrength of the little plates, and the nature of the contained liquor, which is foinetimes more watery, and fometimes more oily : and likewife in the mixture of fibres and threads; of which in fome parts, as in the coats of the arteries, there is a great number ; in others, as under the Ikin, fcarce any. 10. Out of this net-like cellular fubftance, com- pared by the little plates concreting and prefied together by the force of the incumbent mufcles and diftending fluids, or from other caufes, arife broad and flat plates or fldns in various parts of the body, which, being ge- nerally difpofed in a rerilineal diredtion, are more properly called membranes ; or, being convoluted into cones and cylinders, pervaded by a flux of fome juice or liquors through their cavities, put on the name of vejfels ; or elfe, being extended round fome fpace that is in a plane parallel to itfelf, we call it a tunic or coat. But that tunics or coats are formed out of the cellular fubftance is proved by ocular infpedlion, efpecially in the aorta, fkin, pericardium, or dura mater, by mace- ration ; and the coats of the mufcles are thus evidently of a cellular fabric, fimilar to that of other tunics. B 2 The 4 ANIMAL FIBRES. Chap. I. The fame thing is alfo proved from the eafy change of tlie dartos, and the nervous membrane of the inteftines, by inflation, into a cellular fubftance ; from the hard and thick membranes about encyfted tumors, and which have their origin only in the cellular texture ; and, laftly, from that membrane which, being gra- dually compaded mod firmly together, forms the true Ikin lying under the epidermis, and being thence con tinned is partly refolved into the fubcutaneous cellular texture which is filled with fat. 1 1 . All the veflels with which we fee tunics com- monly painted, arc an addition to the cellular net- work, and in nowife conftitute the nature of a mem- brane, but are fuperadded to the membrane itfclf, which is fird formed of the cellular net-like fubdance. Betwixt the maflres or fpaces of the intedinal net-work of velfels, perfedly well filled by the Ruyfchian art of injedion, we dill fee that the white cellular fubdance which remains greatly exceeds the bulk of the vtlTels, although, by their preternatural didendon, they take up more room by dlling more of the fjjace. But for membranes compounded of fibres interwoven with or decuffating each other, I know of none fuch ; unlefs you will take ligamentary or tendinous fibres for them, which yet are fpread only over the face of fome true membrane. 12. This cellular webdike fubdance in the human body is found throughout the whole, namely, where- ever any vefl'el or moving mufcular fibre can betraeed ; and this without the leafh exception that I know of. i:^. The other elementary fubdance of the human body (2.) which cannot be truly called cither a fibrous or cellular plate, is a mere glue evafared and concreted, not within the fibres, but in fpaces betwixt them. In the bones this extravafated fubdance is manifed enough : for you fee the fibres very diftind in the bones of a foetus, in the intervals betwixt which you perceive the veflels running ; fo that every bone in the ikull, on all fides, refemblcs the teeth of a comb. But Chap. I. ANIMAL FIBRES. 5 this fabric is fo altered in an adult perfon, that the juice being extravafated in the fpaces betwixt the fibres, and the intervals thereby filled up, as happens with the juice of madder, plates are then formed of the teeth above mentioned cemented together. The cartilages feem to be fcarce any thing befides this glue concreted. 14. But here the courfe of nature feems to be fuch, that even the filamentary fibres ( 3.) are all firft formed of fuch a transfufed glue. And that the membranous or fcaly fibres of the cellular fubftance (7.) are thus formed, appears from thofe cellular fibres produced in the thorax from a concreted vapour, v/hich joins the furface of the lungs to the pleura ; for thefe perfedtly refemble the true and natural cellular fubftance. The fame appears alfo from a comparifon of the foetus with an adult ; for the large fubcutancous cellular fub- ftance has in a foetus a mere jelly in its ftead inter- pofed betwixt the Ikin and mufcles, wftiich laft we ob- ierve very firm in a foetus : from the morbid diftblution of the membranes of the mufcles into a mere glue : and from a fimdlar change into glue or fize, made on the fkin, tendons, and ligaments of animals, by means of boiling water. This theory is alfo illuftrated from clots of coagulated blood, the fanguineous membranes of Ruyfch, Albinus’s membranes formed of mucus, polypus, filk, and glue. Laftly, that the bones themfelves are formed of compared gluten, is fhown from difeafes in which the hardeft bones, by a lique- faction of their gluten, return into cartilage, flefh, and jelly : fimilar changes are made on the bones of fifties and other animals by Papin’s digefter. 1 5 . It feems, then, that a gelatinous water, like the white of an egg, with a fmall portion of fine cretaceous earth, firft runs together into threads, from fome preiTure, the caufes of w'hich are not our prefent concern. Such a filament, by the mutual attraction of cohefion, inter- cepting fpaces betwixt itfelf and others, helps to form a part of the cellular net-like fubftance, after having acquired fpme toughnefs from the neighbouring earthy particles. 6 CELLULAR SUBSTANCE. Chap.I. particles, which remain after an expulfion of the re- dundant aqueous glue. And in this net-like fubftance, wherever a greater prelfurc is impofed on its fcales or fades, they turn into fibres and membranes or tunics ; and in the bones, laftly, they concrete with an unor- ganifed glue (4.) Hence, in general, all parts of the body, from the fofteft to the hardefl, feem to differ no otherwife than as the latter have more of the earthy particles more clofely compacted together, with lefs of the aqueous glue ; while in the fofteff parts there is lefs earth and more glue. CHAP. II. Of the Cellular Substance and its Fat. 16. I HE cellular fabric is made up of fibres and A plates (9.), which are neither hollow nor vaf- cular, but folid; although they are afterwards painted by an acceffion of veffels. But the principal differences of this fabric are the following. In fome parts of the body it is open and loofe, being formed of long and di- ftant plates ; in others, it is thin and compact, being made up of fhort fibres concreted together. I find it fhorteft betwixt the fclerotica and choroides of the eye, and betwixt the arachnoides and pia mater of the brain. I aifo find it tender, but more conipicuous, betwixt every two coats of the inteflines, ftomach, bladder, and ure- ters ; in the lungs, where it obtains the name of veficies ; under the pulp of the glans penis ; and between the fmall kernels of the vifeera and glands. It is cornpofed of longer fibres, where it is extended over the larger vef- fels, under the name of capjule or vagina ; as through the vifeera, and particularly the liver and lungs ; and is vaflly firmer in the veffels which go to the head and joints. Its principal ufe is to bind together the contigu- ous membranes, veffels, and fibres, in fuch a manner as to allow them a due or limited motion. But the cellu- lar Chap. II. CELLULAR SUBSTANCE. 7 iar fubftance, fo far as we have hitherto defcribed it, hardly ever receives any fat; it is moiftened by a wa- tery vapour, gelatinous and foinewhat oily, exhaled out of the arteries and received again into the veins. The truth of this is eafily deinonilrable from injedions of oil and water, either alone or with fifh-glue, made in all parts of the body. When this vapour is wanting, the iinall hbres grow one to another, and the contiguous membranes or plates are cemented into one, with a lofs of their motion. 1 7. The cellular texture is more lax, and formed of plates rather than fibres, where it divides the mufcles and all their fibres, even to the ultimate fibre ; where it furrounds and fufcains the leafl vefTels with their free motion ; and within the cavities of the bones, where it is alfo made up of bony plates, with membranous ones intermixed. That is Jikewife very lax, which, under the furface of the body, is every where interpofed betwixt the mufcles and the fkin ; but the laxefl of all is that which furrounds the genital parts of the male with very wide cells. 18. Into the empty fpaces of this cellular texture (17.) is poured almofl every where in the foetus, firfl a gelly, then a grumous, and laftly a clotted fat, ail under the fein, and in its fmall hollows. It is compofed of an infipid inflammable liquid, lighter than water, which in a cold air concretes into a folid, efpecially about the kidneys ; and in graminivorous animals, in fiflaes, pro- bably alfo in man, while they are alive, it is very nearly fluid, although apt to be indurated. In it, along with the oil, is united an acid fait in quantity almofl equal to the fixth part of the oil. 19. Through this cellular texture the blood-vefiels run and are divided ; from the arterial extremities of which the fat is depohted and abforbed by the veins. This paffage, from the arteries into the adipofe cells, is fo free and fhort, that there muil needs be very large mouths by which they open, and by which they give admittance to, iniedted mercury, air, water, diSblved fifh- 8 CELLULAR SUBSTANCE. Chap. II. fifh-glue or jelly, and oil not excepted, which is always very fluggilh in paffing through the veiTels even of li- ving animals. Thefe are I'ecreted not by any long ducts, but by tranfuding on all fides through the whole extent of the velTel j infomuch that, when an artery is filled or injected with water, there is no part of the furrounding cellular fubflance but what fwells with the moifiure. The warm fat, during the pulfation of the arteries, ea- fily finds out the fame paflages. How quickly it is col- lected, appears from the fpeedy renovation of it, by a returning fatnefs after acute difeafes. 2 0. But that this fat is abforbed by the veins, we are taught from the hidden effects which exercife of the mufcles more efpecially has in confuming the oil of very fat animals ; alfo from the confumption of our fat in fevers ; from the cure of dropfies, where the water transfufed into the cellular fubflance is in a manner abforbed and thrown out by the inteflinal tube ; and, laftly, from the tranfuding of water and oil from the venous orifices, when injefted by the fyringe. Whe- ther the nerves are fpread upon the adipofe cells, is a queflion. But it is certain they in mofl parts run through this fubflance, and hereby divide, in their courfe, into the minutefl filaments, fo fmall that you can no longer trace them by the knife. But then the fat is both infen- fible and unirritable. 2 I . The intervals or fpaces betwixt the plates or fcales of the cellular membrane, are every where open, and agree in forming one continuous cavity throughout the whole body. This appears from the inflation which butchers, and likewife the lurgeons of Ethiopia, make by a wound of the Ikin, and which raifes the fkin all over the body ; alfo from an ephyfema, in which the air re- ceived by a wound of the fkin, being retained, caufes a fw'clling throughout the whole furface of the body ; the paffage of bodies, put under the fkin, to a place re- mote from that at which they entered ; the paffage of pus, from an inflamed place to remote ulcers ; and, fi- nally, from difeafes, in which a watery or ferous humour Chap.il cellular substance. ^ is depofited into all the cells of this net-like fubftance throughout the body, and is emptied from them all by a fingle incifion. That none of the cellular fabric is ex- cepted from this communication, appears from cafes wherein the vitreous body of the eye has received the flatus of an emphyfema; and again from difeafe, in which the gelatinous ferum of a dropfy has been found, transfufed even into the cavernous bodies of the penis. 2 2. The great importance and ufe of this cellular fubftance, in the animal fabric, muft be evident to all who confider, that from this part alone proceeds the due ftrmnefs and ftability of all the arteries, nerves, and mufeuiar fibres of the body, and confequently of all the flefhy parts and vifeera formed from thence ; and even the figures of the parts, their juft length, cavities, curvatures, flexures, and motions, depend entirely on the cellular membrane, in fome places of a lax and in others of a more denfe and hard fabric ; That out of this fubftance, joined with veffels, nerves, mufeuiar and tendinous fibres (a great part of all which are before formed of this fubftance only), all the vifeera, all the mufcles and glands^ with their ligaments and capfules, are entirely compofed *, and that only from the different length, tenfion, quantity or proportion of this the di- verfity of our glands and vifeera arifes ; and laftly, that this alone makes up by far the greateft part of the whole body, as we are certain, although the whole be not formed out of cellular filaments of this kind. 2^. This fubftance hath a contradlile power, diffe- rent from that of irritability, which, though not de- monftrable by experiments, for the moft part difpofes the cellular fibre to fhorten itfelf after having been ftretched. This power, excited by cold, renders the fkin rigid ; raifss the hairs ; draws up the ferotum ; and, after geftation, reftores the fkin of the abdomen, and the uterus, to their former fize. The fame force, by a gentle but continual contradion, promotes the fecretion of the fat, the liquors of the fubcutaneous and other glands, and pus : in the veins and receptacles, it refills C dilatation j io CELLULAR SUBSTANCE. Chap. II. dilatation; and, when that is taken ofF, it reflores the part to its former fize. In the foetus, this gentle force is among the principal caufes of the change that hap- pens to the body. 24. The ufes of the fat are various ; as to facilitate the motions of the mufcles in all parts, leffen their at- 'trition againft each other, and prevent a ftiffnefs or rigidity: it fills up the intermediate fpaces betwixt the mufcles, with the cavities about many of the vifcera, in fuch a manner, that it readily yields to their motions, and yet fupports them when at reft : it principally con- ftitutes the weight of the body ; conducts and defends the veffels : it gives an uniform extenfion to the fkin ; and, ferving as a cuftiion to eafe the weight of the body, renders the whole of a comely, agreeable ftiape : it pro- bably, by mixing with many of the humours, abates their acrimony : it has a principal ftiare in forming the matter of the bile; and, by tranfuding through the car- tilaginous incruftations of the bones, it mixes with the articular liquid, and by abforption ferves to fmear their fibres : by exhaling through the pores of the Ikin, it keeps off the inclement drying quality of the air : alfo, by exhaling in a living perfon from the mefentery, me- focolon, omentum, and round the kidneys, it lubricates the furfaces of the vifcera with an oily emollient vapour; and, by interpofing betwixt their integuments, prevents their growing one to another. 25. The fat is depofited into the cells of this fub- ftance by fleep, reft of body and mind, and a diminilh- ed force of circulation ; whence, being collected in too great a quantity, it proves injurious by comprdfing the veins ; and, by caufing too great a refiftance to the heart, it makes a perfon fhort-breathed, and liable to an apo- plexy or dropfy. The fame humour is taken up by the veins ; and, being rapidly moved along the arteries, is confumed by violent exercife, venery, watchings, cares of^ the mind, a falivation, diarrhcea, fever, fafting, or fuppuration. When reftored to the blood, it increafes acute difeafes, tinges the urine, and forms a part of its fediment. II Chap. III. ARTERIES. fediment. After a fudden confumption of it, it is foon renewed again from good juices, or healthy humours : but, in a languid habit, a gelly, inftead of fat, is depo- fited into the cells ; and this caufes the dropfy we call anafarca, together with an external hydrocele or watery fwelling. CHAP. III. Of the Arteries and Veins. 26. HE membranes we fhall hereafter better de- X fcribe, each in its refpeftive place. Of thefe membranes there are feveral common to the ar~ teries ; which are long extended cones, whofe dia- meters decreafe as they divide into more numerous branches. But where the arteries run for fome length, without fending off large branches, their convergency is not very evident ; and at length, where they are called capillaries, and wherever they give paffage to only a fmgle red globule, they are either cylindrical, or very nearly fo, from the imperceptible diminution ; but their tranf- verfe fedlions are every where and without exception circular, when the artery is full. Where they fend off large branches, the light or cavity is there fuddenly di- minifhed, infomuch that they might be taken for a chain of cylinders, of which every one is narrower than the preceding. If you reckon them cones, then the common bafis of the cone in all arteries is either in one or the other ventricle of the heart ; and the apex of the cone terminates either in the beginning of the veins, or in the beginning of the cylindrical part of the artery, or in the exhaling veffel, unlefs it is cylindrical. In fome places they feem to diverge or dilate ; at lead: they become there of a larger diameter, after they have been filled or dillended with wax ; which poffibly may arife from fome ftoppage of the wax, by whofe impulfe that part of the length of the artery becomes more di- C 2 ftended 12 ARTERIES. Chap. IIT. {tended than the reft. Examples of this kind we have in the vertebral artery, at the bafts of the Ikull, in the fplenic artery, in the flexure of the carotid artery, ac- cording to Mr Cowper’s injections ; and, laftly, unlefs all my experiments deceive me, in the fpermatic arte- ries. In all places, likewife, where the ramifications be- gin, the diameter of the artery is a little increafed. 27. There is indeed no external coat perpetual and proper to all the arteries ; but the office of fuch a coat is fupplied to fome of them by one fingle external and incumbent integument, which in the thorax is the pleura, and in the abdomen the peritonseum. In the neck, arm, and thigh, a fort of thicker cellular fub- ftance furrounds the arteries. The membrane of the pericardium, which on all Tides clofes round the aorta, returns back with the veflfels to the heart. The dura mater imparts a capfule that furrounds the carotid ar- tery as it pafles out through a hole in the fkull. But the firft true external membrane common to the arte- rial tube in all parts of the body, is the cellular fub- ftance, which in fome parts (as in the thorax) we fee replenifhed with fat. 28. This cellular coat is, in its external furface, of a more lax texture, painted with a great many fmall arte- ries and veins ; and it has nerves running through its fubftance, which are none of the fmalleft. There is fometimes fo much of this cellular fubftance about the artery as might occafion one to think it hardly belonged to it as an external coat or lamella, but rather as fome foreign net-work added to this veffel. Thus we find it in the arteries of the neck, groins, and fubclavians ; in the mefenteric, coeliac, and hepatic arteries ; where it is chiefly interwoven with long fibres. And thefe are the vaginae or capfules of the arteries, formerly obferved by fome eminent anatomifts. 29. As this cellular coat advances more inward, and nearer to the light and capacity of the artery, it be- comes more denfe^ folid, and is tied more clofely toge- ther by a kind of wool, and may be called the proper coat Chap. III. ARTERIES. 13 ceat of the artery. That there is no tendinous coat of the arteries diftinft from this laft part of the cellular fubftance, is evident from maceration, whereby the in- ner ftratum of this arterious tunic changes into a cel- lular fabric. 30. Within the former, and nearer the light or ca- pacity of the artery, it has a coat of mufcular fibres^ which are in general imperfecl circles : that is to fay, no fibre any where makes a complete circle round the veffel ; but a number of fegments conjoined together, with their extremities turned off fideways, feem to form one ring round the artery. Thefe fibres, in the larger arterial trunks, form many firata, appear of a reddilh colour, and are remarkably firm and folid ; but in the fmaller arteries they are by degrees more difficult to demonftrate, and feem to be wanting in the arteries of fmall animals. 1 have never obferved them to run along the vefl'el lengthwife. Under thefe membranes, but pretty difficult to demonftrate, is an exceeding ffiort cellular texture, into which a chalky concreting matter is poured when an artery offifies. 31. The innermofl coat of the artery is thin, and fine- ly poliffied by the influent blood ; fo as to form a Angle incruftation that every where lines the fleffiy fibres, which are not very continuous one to the other, and prevents the blood from infinuating into the fpaces be- twixt them. It is every where fmooth and without valves ; although, from a fort of mechanical neceffity, fdinetimes certain folds, raifed into a femicircle at the origination of branches, form a projefting eminence ; as we fee at the branches produced by the arch of the aorta. Yet, in arteries of the vifcera, the innermofl coat is fofter, lax, wrinkled, and almofl friable, efpe- cially in the dudus arteriofus. 32. The arteries themfelves have arteries which are more particularly fpread through their external cellular coat ; and, fpringing on all fides from the next adjacent fmall arterial trunks, form numerous branchy net- \vorks, which are all of them indeed very minute, but plainly 14 ARTERIES. Chap. III. plainly appear, even in the foetus without injection, to be very numerous. There are alfo nerves which de- fcend for a long way together through the furface of the artery, and at Tall vanifh in the cellular fubftance of the veffel ; of which we have a fpecimen in the external and internal carotids, and arch of the aorta. And from thefe, do not the arteries feem to derive a mufcular and eonvulfive force, very different from that of their fimple elafticity ? Does not this force fhow itfelf plainly e- nough in fevers, faintings, palfy, and confumption, and paffions of the mind ? But the artery is in a manner infenfible and unirritable ; and if it is conftricfed by the application of poifons, it has this in common with the dead fkin. The fedions, or divifions, of arteries (howthem- felves with a round light, or hollow capacity, becaufe they are elallic ; and this is the reafon why, from the fmall arteries of the teeth, haemorrhages are fometimes fatal. The aorta, indeed, of the thorax and abdomen, the carotids of the neck, and fome other arteries of the dead body, from their leffened extenfion, appear fome- what fiat or depreffed ; but their round figure, or cir- cular feftion, is every where reftored by injedlion. Their elajiicity is alfo evident in that powerful com- preffure, which a fegment of a large artery makes upon the finger that diftends it, and which is much ftronger in a dead than in a living body. In the living body, indeed, this force yields to that of the heart ; but in- ffantly recovers itfelf, when the heart is relaxed, and reffores the artery to its former diameter ; and this makes the pulfe, whofe full explication ought to be preceded by an hiftory of the heart : at prefent, it may fufiSce for us to fay, that all the arteries have this pul- fation, although the fyftole and diaftole thereof can be perceived by the finger, only in the larger, not in the fmaller ones naturally ; and in the ultimate inflexion of the arteries, the pulfe totally vaniliies ; but, by an in- creafed motion of the blood, even the leffer arteries niake a violent pulfation, as we fee in an inflammation. Thefe Chap. III. ARTERIES. 15 Thefe veffds ftrongly contrad lengthwife, and are ren» dered fl^orter on dilfedion. 3^. The Jlrength of the arteries is confiderablc enough : but as the denfe, hard net-work of the outer cellular coat refufes to yield to a dillending force, it breaks without much difficulty, almoU ealier than the coats of the veins ; and from thence arife aneurifms. But, in general, the trunks are, in all parts of the bod)'-, weaker, and the branches llronger, in their coats ; whence the impulfe of the blood may exert a conli- derable elfed upon the former, but leaf! of all on thofe of the limbs. From hence it is, that aneurifms are moll frequently formed near the heart ; for, in the lower ex- tremities, the llrength of the arteries, and of the veins too, is much increafed, as well as in the fecreting or- gans. 35. With regard to the courfe and general diftribution of the arteries, nature has every where concealed them, except in a few' membranes. But ffie hath difpofed of the trunks every where in places of fafety, becaufe wounds cannot happen to the fmaller of them without danger, nor to the larger without lofs of life. The Ikin is fpread with numerous ffiort and fmall arterial trunks ; but the larger ones, defended by the fkin and mufcles, creep along near the bones. In general, the arteries are in proportion to the parts of the body to which they are fent. The largell go to the fecretory organs, the brain, and fpieen ; the lefler ones to the mufcular parts. 36. The proportion of the light or cavity of the ar- tery to its folid part is not every where the fame, nor is it conflant even in the fame artery. This proportion, in the firft place, is leall of all at the heart, and in- creafes as the arteries remove farther from it. Second- ly, in a full-fed plethoric animal, whofe blood paffes freely, and with great force, through its arteries, the proportion of the folid parts of thefe velfels is lefs than in a familhed extenuated creature, whofe blood hath a feeble motion. 37. From i 6 ARTERIES. Chap. III. 37. From the trunks of all the arteries branches are fent forth, and from thefe again proceed lelfer twigs by a numerous divifion, of which you can fcarce find the end, though you may perhaps count twenty fubdi- vifions of this kind. Here the lights or feclions of any two branches, taken together, always exceed the light of the trunk from whence they come, in nearly a fcf- quialteral proportion, or as one and a half to one, or fomewhat lefs. Alfo every trunk, juft above its divi- fion, is fomewhat broader or more expanded. The angles, at which the branches go out from their trunks, are generally acute, either half right angles or nearly fo ; to the forming of which angles, as we fee in me- chanics, there is required thelongeft projcftion. In- ftances of their going off at right angles, or nearly fo, we have in the lumbal or intercoftal arteries ; of their going off in a retrograde or reflefted courfe, we have one inftance in the coronaries of the heart, and ano- ther inftance in the fpinal arteries, which are produced by the vertebrals. But, generally fpeaking, thofe which are efteemed retrograde or reflexed were fent off, at their origin, in acute angles; fuch as the afcend- ing artery of the pharynx, the defcending one of the palate, the umbilical mammary arteries, and the nutri- tious ones of the large bones. Laftly, we often ob- ferve large branches arifing under leffer angles, and fmaller ones under greater angles : but it is rarely that we obferve two arteries of a large diameter run toge- ther into one trunk. An example of this, however, we have in that artery which is formed out of the ver- tebrals ; in the fmaller ones it is frequent, as in both the fpinal arteries, and that of the fincipital foramen. In many parts, the arteries have repeated alternate un- dulations or flexures, as they run on in a fpiral courfe, wherein we fee their diameter often confiderably en- larged, as in the large inteftines, womb, face, fpleen, lips, and iris. Even the ftraight arteries in other places, if too much diftended, fall into ferpentine flexures. Sometimes they are fuddenly twifted into a kind Chap. III. ARTERIES. 17 kind of circles, as the carotids under the mammillary procefs. 3 8. The arteries are frequently conjoined one to another by intermediate branches, in fuch a manner, that the twig of fome certain artery fliall run to meet one of the fame kind from anodier neighbouring arte- ry, and, by joining together with that, form one trunk. Inllances of this kind we have among the large trunks in the inteflines, among the middling ones in the kid- neys, womb, &c. and among the fmaller ih all parts of the body ; infomuch that there is no part of the human body wherein the neighbouring arterial trunks, whe- ther of the fame or of different denominations, do not form anaftomofes or joinings one to the other by in- termediate branches. Of rings diverging laterally from the arteries, and returning again into themfelves, we have inllances in the eye and brain. The extremi- ties of the arteries, which are either cylindrical or near- ly fo, fend off fmaller branches, which, for their ex- tent, are more numerous, and generally difpofed like a net ; fo that each branch, by its fmaller twigs, forms anaftomofes with thofe of its neighbouring branches : and thus we find it in all membranes. By this means it happens, that, though the palfage from the heart to any part of an artery is obftrudled, the blood may ne- vertheiefs flow through the neighbouring arteries into ail the branches of the obftrudled one. Thus a gan- grene or languor of the part is very ftrongly prevent- ed, and the obftruftion is more eafily refolved by the repulfion of the obftacle into the larger part of the trunk. 39. Laftly, one of the leaft arteries is either chan- ged by a continuation of its canal into a vein, in fuch a manner, that the ultimate little artery, which is ge- nerally reflected, having furpaffed the angle of its re- flgction, becomes now a fmall vein ; or elfe a branch, fent out at right angles from the artery, is inferted un- der a like angle into the branch of a fmall vein. Both thefe kinds of mechanifm are demonftrated to us by D the 28 ARTERIES. Chap. III. the microfcope, and the eafy return of injeclions thro’ the veins into the arteries. And thefe vafcules we fee fometimes large enough to receive only one, and fome- times feveral blood-globules at a time. A large artery is never obferved to open into a vein. 40. In the vifcera, we find the fmall arteries difpo- fed not ib much in net-works as in a dilferent fabrica- ture, wherein the fmall branches defcend very thick, or in clufters, parallel to the trunk, fo as to refemble brufh-pencils, a variety of little trees or bufhes, fmall ferpents, or threads, according to the various difpofi- tion of the parts. 41. Sometimes the arteries end in another manner, namely, by being converted into veffels of the fmaller kinds. Thefe are fometimes continuous to the arte- ries and real arterial trunks, as will be obferved in the ophthalmic artery, upon tracing the arteries of the tu- nica choroides, or the colourlefs ones of the circle of the uvea and iris. That a net-work of pellucid arteries is continuous with the red branches of the ophthalmic one, is evident from inflammations, and the rednefs of the parts when relaxed by vapour or by cupping ; from repletion, and the microfcopical experiments of Lieberkuhnius upon frogs, in which colourlefs glo- bules were feen to pafs from a red artery into a lateral velfel. In a fabric of this kind the red blood is eafily forced into the fmaller vefl'els. 42. In other places the fmaller veffels feem to pro- ceed laterally as branches from the trunks of the leafl fanguineous arteries, and are drawn out into trunks {till fmaller. Thefe are called excretory duds. It is with difficulty that thefe veffels are filled with red blood ; of this, however, we have examples in the kidneys, the liver, and breafts. Indeed the blood, when vitiated, penetrates the excretory duffs of the whole body, even without hurting the veffels, nor is that aberration found to be productive of any evil con- fequence after the diforder of the blood is cured. 43. Another Chap. III. ARTERIES. ig 43. Another termination of the arterial extremities is i}ito the exhaling vejfels ; and this is a manner of their ending very frequently to be obferved in all parts of the body. The whole fldn, all membranes of the human body which form any clofe cavity, all the ventrides of the brain, the anterior and poflerior chambers of the eyes, all the adlpofe cells and pulmonary veficles, the whole cavity of the ftomach and inteflinal tube, thro’ which the air has a paffage, are all of them replenifhed with exhaling arteries of this kind. Thefe breathe ou6 a thin, watery, gelatinous humour, which, being col- lected together by (landing, fometimes makes no in- confiderable quantity; and, particularly by difcafe or death, is converted into a watery, but coagulable lymph. The truth of this is eafily demonflrable from the watery fweat that enfues after injeCling the arteries with that liquor warm. In fonre places, indeed, they exhale, not a thin vapour, but blood itfelf, as we fee in the heart, the cellular fabric of the penis, urethra, clitoris, and nipple of the female breaft ; in all which the blood itfelf is naturally poured out.' Does not eve- ry fecretion that is made in true glands or hollow cryp- tas bear fome analogy to this exhaling fabric ? 44. Whether or no, in all parts of the human body, do the pellucid veffels arifmgfrom the fanguineones, and carrying a humour thinner than blood, again fend out other fmaller veffels to be fubdivided into ftill leffer or- ders? ~We feem, indeed, not to want examples of this in the manner propofed to us by the moft cele- brated profeffors. That the aqueous humour is fepa- rated by very fine veffels, generated from the colour- lefs arteries of the iris, is very probable. That the red- coloured veffels in the cortical fubftance of the brain feparate a juice, pervading the medullary fubftance, by the intermediation of another order of veffels, we are almoft certain. And the like we are perfuaded from an eryftpelas or yellow inflammation, arifing from the yellow or ferous globules impaCled into fmaller vef- fels. D 2 45. It 20 ARTERIES. Chap. IR. 45. It may be then afked, If there are not yellow arterious veffels of a fecond order, which fend off lym- phatic ones of a third order, from whence by degrees If ill leffer kinds of veffels branch out? Such a fabric does not feem agreeable to the very eafy tranfuion that is made by the blood, mercury, or \vax, into the ex- haling and perfpiratory veffels, or into the uriniferous tu- buli, with the adipofe and pulmonary cells ; nor is it very difficult for the blood to ftray into the lactiferous, lymphatic, and lachrymal duCts, whither it ffiould feem not able to penetrate, if it went through any ’ other intermediate vafcular fyffem, fmaller than the blood-globules, which make the fame journey. Nor can this fyffem be allowed by the great impediment or retardation that muif arife to the humours in a third, and much more in the leffer orders of veffels, 46. The Veins, in many particulars, rcfemble the arteries. There are fix, of which two anfwer to the aorta, and the remaining four to the pulmonary artery. Their bafis is in the ventricles of the heart, and their apices in the extremity of each branch, through ail parts of the body, excepting one inftance in the liver. And, in a great number of parts, they run parallel with the arteries, one by the fide of the other ; but yet they differ from the arteries in various refpeCfs. 47. The fabric of the veins is flender, every where finooth, difficultly feparable into diffincf coats or mem- branes, like tli« arteries; and the cellular texture fur- rounding this fabric is very eafily diftend^d. This fa- bric, both above and below the heart, is furrounded, except in one place, with mufcular fibres. Every where, however, it is lax, like the cellular texture of the arteries by which they are joined to the other parts of the body. Notwithlfanding this {lender fabric, the veins are every where fufficiently firm, and do not eafily burft with inflated air ; being, in inofl inftances, ftronger than the arteries themfelves. But they bura much more eafily in living than in dead animals, as appears from morbid inftances in the arm, face, leg, thigh, Chap. III. VEINS. 21 thigh, &c. Nor do they fupport themfelves like cy- linders after being divided, but they collapfe together, lb as to make their light or capacity appear like a flit ; except they are fuflained and hindered from collapfing thus by fome ftronger cellular fubftance placed round them, as we fee in the liver and womb. They are but nightly irritable, unlefs the ftimulus be of the chemical or more acrid clalTes ; for, in that cafe, they contrad themfelves with a convulfive force greater than that of the arteries. They have no pulfation, if we may trull all accounts, unlefs the venous channel is fome- where obftrufted ; or when, in dying people, the blood is thrown back again from the right apricle into the defeending and afeending cava, or when falling back from the brain. 48. The veins are m.uch larger than their corre- fponding arteries, having the fquare of their diameter often double or triple that of the latter ; and, in fome places, almofl quadruple ; as near as the emulgents and veffels of the kidneys. In general, however, the diameter of the veins is to that of the arteries as nine to four ; yet the capacity of the capillary veins but little exceeds that of the arteries which accompany them. They differ likewife from the arteries in their divifion, having more numerous trunks and branches; for to one artery in the limbs, we ufually meet with two veins. The larger veins are alfo branched in a more net-like difpofition, by forming more frequent anaftomofes one with another ; for not only the fmall- er branches, but even the larger trunks, of the veins, are conjoined one to the other within its neighbour- hood, upper with lower, and right with left, by appa- rent inlets or inofculations. They affedl to run near the furface of the body ; and through the limbs, neck, and head ; they run a long way covered with little more than the bare fkin, which is a circumftance we very rarely obferve in arteries ; and, for the fame rea- fon, they often go out, in their courfe, to a confiderable diftance from the arteries. For, in this cafe, the veins follow 2 2 VEINS. Chap. III. follow the furface of the parts next the without their correfponding artery, which, in the mean time, dcfcends to a confidcrable depth, attended in its courfc by fomefmaller venous branch. In the fmaller branches of the velfels, where they make net-like difpofitions in the membranes and the internal fabric of the vifce- ra, the veins and arteries commonly run contiguous one with the other ; but here the veins have generally a lefs ferpentine or inflected courfe. 49. In the larger fanguineous veins, little valves are found in great plenty. The innermofl; membrane of the vein, being double, rifes into the cavity of the vef- fel like a curtain, ftretching itfelf farther along the vein every way, fo as to form what may be cafled a a kind of little horns ; but the bafls, which is the part that fuftains the weight of the blood, is llrongefl, and grows out of the vein in the fhape of a circular feg- ment. Thefe, joined with the fide of the proceeding vein, intercept a fpace, of w^hich the outer fide is the vein itfelf, and the inner the valve, which, by its con- vexity, {lands out within the bore of the vein ; fo that the parabolic fpace or hollow mouth of the valves al- ways looks towards the heart : they are found in all the fubcutaneous veins of the limbs, in thofe of the neck, face, tongue, and in the veins of the penis : at the origin of the larger branches there are two, three, four, and fometimes five of them together, while in their fmaller branches they are only fingle. There are none of thefe valves in the deep running veins of the vifeera ; and, therefore, none in thofe of the brain, lungs, heart, or liver, or through the whole fyilem of the ve- na pertarum, nor in the kidneys or womb (except one or tw'O valves in the fpermatic vein); nor, laftly, are there any in thofe fmaller blood-veins, which are of a lefs diameter than the twelfth part of an inch. Some- times, though rarely, they are found in the vena azy- gos, and at the mouths of the hepatic and renal veins : there I have feveral tunes obferved a fort of wrinkles in the place of valve's. In the fmaller venous branches there Chap. III. VEINS. 25 there are a fet of long, fliarp-pointed or parabolical valves, of a more extended figure as the vein is fmall- er ; and thefe make a greater refiftance than the larger valves, to hinder the blood from returning back upon the parts. 50. I'he veins have their origin, as we faid before, from the terminations of the arteries. They fome- times arife by a continuation from the inferted branches, or from a refleftion of recurved trunks of the fmalleft arteries. Others again are either continued from veins lefs than thofe which carry blood, or elfe receive addi- tions and roots from them ; as we fee, for inftance, in the lymphatic veins of the thoracic dudi. Others of a bibulous kind take their origin from the abforbing veins that are difperfed all over the furface of the body, as in the chambers of the eyes, the cavities of the inteflines, bladder, womb, breaft, peritonaeum, pericardium, and ventricles of the brain. From thefe iffue a watery fweat, by injeding the venous trunks with that kind of liquor, which may be eafily imitated throughout the whole human body : hence water, jel- ly, or oil, diftil from the the vena portarum into the cavity of the inteftines ; hence alfo water, injeded into the abdomen of a living animal, quickly vaniflies : but of thefe things we fliall fpeak more largely in a proper place. 51. Not much differing from the former are thofe veins which, arifing in all parts of the cellular mem- brane, return thin vapours, dropfical waters, diffolved fat, or extravafated and corrupting blood, and the poi- fon of opium introduced into the cellular texture, again into the mafs of the blood ; or which take up again and return the blood itfelf from the cellular fa- bric of the penis, clitoris, or nipples of the breads, af- ter the venereal ad. And that inhaling veins of this kind open into all the glands, is highly probable ; where, by abforbing the thinner humour, they leave the remaining mafs of a thicker confidence, of which we have indanccs in the bile, fperm, mucus, &c. 52. That 24 VEINS. Chap. IIL 52. That there are veins of a fmaller clafs, but re- fembling tliofe which convey blood, appears from the fame experiments which deraonftrate the pellucid arte- ries : thus, in the iris of the eye there are fmall veins, and not a few in the adnata tunica of that organ j nor is it to be doubted that, in a healthy body, fmall pellu- cid veins may be found in the vitreous body of the eye itfelf. 55. But, in mofi; parts of the human body, are found other veins, full of a reddilh, yellowifii, or al- moft pellucid liquor, cpagulable by heat ; which veins, being formed of very tender coats, have a degree of irritability from any chemical or very acrid Itimulus. They have very frequent valves or partitions, which make them in thofe places feem jointed or knotted like a reed w'hen they are turgid ; thefe, by degrees, meeting together, either all or molt part of them empty their contents into the thoracic duel. They arife from the cellular texture throughout the whole body, as I long ago learned concerning the laftiferous veficls of the breafts, the vafa efferentia of the tefticles, the lynv phatics which originate from the mefenteric glands ; and as is now fKown to be the cafe with the lymphatic veifels of tlie tefticles, fpleen, and other parts. From analogy, efpecially from hydropical appearances, it is very probable that they arife likewife from the large cavities of the body; nor is it improbable that this kind of veffels receive a thin humour from veins of the fmalleft fize. But all the lymphatics, in their courfe, meet together in a peculiar kind of conglobate glands, into which they enter ; and, from the lhape of veins, becoming arterial, or like converging cones, they di- vide into fmall branches, and then proceed to meet to- gether again in other little trunks. 54. Thefe glands themfelves are only as it were fmall clues of lymphatic veffels, connecled together by a cellular texture, into which the arterial liquour ex- fudes, and is conveyed from the fame bv the veffels which ferve to bring back the lymph. They are co- vered Chap.IIL veins. 25 vered with a continuous membrane, almofl; of an oval lhape, and this whether they are Angle or heaped to- gether : and they chiefly follow the courfe of the veins through the whole trunk of the body, even to the tops of the limbs ; running along the jugular and fubclavian veins, the vena cava fuperior, the afpera arteria, gullet, lumbal vena cava, vena porta, the iliac, hypogaflric, and crural veins, the veins of the thigh, and likewife the vcflels of, the ilomach, fpleen, mefentery, and mefo-» colon. 55. They are found feated on all the furfaces of the vifcera, in the thorax and abdomen ; but are more eafily difcovered in brutes. They run through the lower part of the face, mufclcs of the tongue, the ad- jacent parts of the neck, and thofe parts of the upper limbs v/hich are nearefl; the trunk, as far as the bend- ing of the elbow ; throughout the whole length of the mediaftinum, before and behind, and wherever we find conglobate glandules, either in the neck or tho- rax : the lymphatic veins are alfo fpread through the whole lumbal region that is contiguous to the aorta, the mefocolon and pelvis, velfels and furface of the teilicle ; and in the lower limbs, wherever they are fupplied with conglobate glandules, even to the knees. Whether they extend further into other parts through- out the whole body, or through the brain, eyes, hands, feet, back, fore part of the peritonseum, &c. remains as yet undetermined ; at leaft, there are not examples enough in the human body upon which one can depend to evince the truth of their exiftence. But they are eve- ry where to be found upon the furfaces of the vifcera. They are almofl: every where collefted into bundles, not far from the large blood-veflels. Thofe from the inferior limbs, pelvis, and loins, run into one duft, which is joined by another bundle coming from the li- ver, fpleen, and ftomach ; and that trunk, at length, becomes the thoracic du£l. The fuperior veflels, from the whole extent of the breaft, the head, and fuperior limbs, empty themfelves into the fame du^l towards its E upper upper extremity. They feem, however, likewife to termuiate in the red veins. 56. Of what fervice thcfe glands are to the Ivm- phatic veffels is not well known. In the fetus they are fwelled with a milky liquor, as alfo the thymus and glandulae renales ; but it is not certain whether this juice is poured out into the cellular texture. It is ren- dered probable by late experiments, that fome kind of juice is prepared in thefe glands, which is mixed with the lymph ; and that a thin humour, injedted into the arteries, likewife enters the lymphatic veiTels. By age, this juice vaniflies ; and the glands themfelves, being dried up, almofl totally difappear. A very fudden feirrhus happening to thefe glands feems to be the caufe of their decay. 57. The vahes of thefe pellucid veffels (53-) are compofed of two femicircular membranes, which give way to the fluid that goes towards the larger trunks ; fo that, by applying themfelves clofe to the fides of the veffel, they leave a free light or capacity through it. But the fame valves, if the contained liquor is preffed back towards the fmaller branches of the veffel, being filled out therewith, fwcll or expand, fo as to (hut up the light of the canal. Of the Circulation or Motion of the Bi.ood through the Arteries and Veins. HE arteries and veins, whieh we have hitherto deferibed, contain either blood or lymph. The red blood, whofe nature we Ihall explain when we come to treat of fecretion, fills the arteries and veins com- monly known, which we call red, or thufe of the firft order, and which have their origin in the heart. Thefe it fo fills in a living perfon, that at fome times they are very loofely and imperfedly diftended by it, and CHAP. IV Chap. IV. CIRCULATION, &c. 27 at other times they are rendered very full and turgid. After death, the veins are found fuller of blood than the arteries ; but fometimes, when the perfon has been dead a confiderable time, the fmall veins have been found diftended with air. But the arteries of a dead body commonly contain only a fmall quantity of blood. 59. This diftending blood, then, is rapidly moved through all the veflels of a living body. The truth of which is demonftrated to us from wounds, by 'which the patient foon expires, from the lofs of fo much blood as was necelfary for the maintenance of life j which lofs of blood happens almoft inilantly from the larger arteries, and fometimes very fuddenly from the fmaller ones : but from the veins, unlefs they are fome of the largeft, this lofs of blood is more How and difficult ; yet are there not wanting inftance's of fatal haemorrhages from wounds of the veins, in the inner corners of the eyes, and thofe under the tongue. Experiments made upon living animals, fufficientiy evidence the impulfe and rapidity with which the blood is moved, particu- larly through the arteries. In the larger trunks, it runs moft fwiftly ; but, in the lead: of them, fomewhat flower. And, in the larger veins, the blood’s celerity is lefs thaa in the arterial trunks, in the fame proportion as the lights or feftions of the arteries are lefs than thofe of the veins, i. e. twice or almofl; thrice flower. Another argument of the circulation, is the compreffure and re- laxation of a vein, whereby the motion of the blood is promoted from one valve to another This motion of the blood is, in the veins, uniform or equable enough ; but, in the arteries, it is alternately greater when the veffel is more dilated, and lefs when it is contracted. This is proved by ocular infpedion in living animals. 60. That the motion the blood deferibes is a courfc through the fanguineous arteries into the veins, is dif- covered from experience. For, firfl, it is certain, that all the arteries and veins communicate or open one in- to the other ; becaufe often, from one, and that a fmall artery, all the blood fhall run even until death, and E 2 make 28 CIRCULATION, &c. Chap. IV. make all the flefh exceedingly pale ; and this not only out of the wounded limb, but from the whole body. Of fuch fatal examples we have a number, from an in- ner artery of the nofe, from the gums, a finger, tooth, cutaneous pore enlarged, from the lachrymal point, from the wound of cupping on the fkin, and even the bite of a leach. There are, therefore, of courfe, open ways by which the blood fpeedily flows from the venous into the arterial fyftem. 6 £ . That the blood, again, in the arteries, flows from the heart toward the extreme parts of the body, is proved by the microfcope, an-d by a ligature on the ar- tery of a living animal. For whatever artery fliall be flopped by a ligature, a fwelling enfues in that part be- twixt the heart and the ligature, whilfl; the other part is emptied beyond the ligature, which is the part of the artery more remote from the heart: neither has it there any pulfation; nor, if it be there wounded, will it yield any blood. The fame eftecls which we fee follow from a ligature, are likewife often produced by difeafe ; as when fome tumour, by cornpreffure, or an aneurifm, in- tercepts the motion from the heart. Experiments of this kind have been made by us on moft of the arte- ries ; anaflomofes, however, or the blood flowing through a neighbouring branch, or the retroceffion of the blood in a dying animal, form exceptions to this rule. 62. But for the courfe or motion of the venous blood, it has been always more doubted of ; almofl all the an- cients have been perfuaded, that the blood in the veins flowed through them, either from the heart or from the liver, to all parts of the body. Very few of them have known, that this was an error. Several of them have, indeed, acknowledged it to be falfe in the pulmo- nary vein. But that the blood did not move from the heart in the vena cava was known to flill fewer anato- mifls of the ancients ; perhaps only to Andreas, Cte- falpinus, and (from an extraordinary accident) to Vefa- lius. ^3. Chap. IV. CIRCULATION, kc. 29 63. Dr William Harvey is the firft who experi- mentally aflerted the motion of the blood returning in' the veihs to the heart, in fuch a manner as to render the whole intelligible, and leave no room to doubt of it. And, firft, the valves of the veins lead us to this truth : for the common ufe or office of thefe valves is, to determine the preflure that is given from any quar- ter upon the veins, towards the heart, by allowing no opportunity to the venous blood,'that has once entered the trunk, wffiich they intercept, to flow back to the branches. For, fince the covering fpaccs of the valves open upwards towards the heart, the blood enters into and expands them. Thus thofe parts of the valves which ftand out with a free motion within the light of the vein, approach each other towards the axis, until the oppofite fides, by meeting together, fiiut up the tube. This we know from inflations, ligatures, and injeftions of the veins ; for you never can force a li- quor eafily into the veins by urging it againft, or con- trary to, their valves. They do not, indeed, every where fliut up the whole cavity of the veins ; but where they ffiut not clofe, they always intercept the greateft part of the light. 64. Another office of the valves in the veins feems to be for fuftaining the weight of the blood, that its upper columns may not gravitate upon the lower ; nor the blood, flowing through the trunks, make too great a refiftance againft that which follows it through the branches. For if, from the flower return of the blood into the veins, its weight or preflure fhall, in any part, much exceed the impulfe that drives it on, fo as to caufe fome part of the column to defeend by its weight ; it is, in that cafe, immediately catched, and fuftained in its relapfe by the next adjacent valve, which hinders it from urging againft the next fucceeding column, and affbrd:s time and opportunity for fome contiguous mufcle, by its preflure or concuffion, to fend forward the faid column. And this is the reafon why valves _are placed in veins of. the limbs and neck; in which parts 30 CIRCULATTON, &c. Chap. IV. parts they are both more numerous and more robufl: than elfewhere. And this is the caufe of varices, when the blood, entering the hollow valves, urges their folid convexity downwards, and makes the vein dilate in that part. Likewife, in mufcular motion, the valves occa- fion the whole prelTure which the veins then fulfain, to forward the due courfe of the blood towards the heart. 65. Moreover, the valves, placed in the right ven- tricle of the hearty have fuch a fabric, as we {hall here- after fee, that they freely permit blood, flatus, or w'ax, to pafs from the venous trunks of the cava into the heart, but deny any paffage from the heart again into the veins. 66. Again, ligatures^ in a living perfon, may make the thing more evident. When the veins of the limbs are tied, either by defign or accident, with the limb it- felf about the hams, arms, ancles, or wrifts, the limb be- low the ligature fweils, the veins fill and diftend them- themfelves, and when opened make a free difeharge of blood : but, at the fame time, nothing of this kind hap- pens above the ligature, nor are any of the veins to be feen there. The fame phenomenon happens when the veins are compreffed by fwelled and feirrhous glandules in the vifeera ; and from polypufes the veins are often largely fwelled, or enlarged into tumours. Thefe liga- tures will ferve to keep the blood in any limb round which they are tied, that it may not return to the heart and be loft through a wound in another part. 67. The experiments to prove this courfe of the blood, which have been made in living animals, are Hill more accurate. From them, even from our own, it appears, that, by tying any vein, in a living animal, near the cava, or belonging to the pulmonary veins, that part always fweils which is moft remote from the heart, all below' the ligature appearing diftended with the retained blood, white above and next the heart they are pale and flaccid. Laftly, if the arteries are tied at the fame t’.miC with the veins, thefe laft remain flaccid and empty ; but, upon Chap. IV. CIRCULATION, &c. gt upon removing the ligature from the arteries, the veins are immediately filled. In like manner, the infufion of poifons or medicinal liquors fhew, that, into whatever vein you injed chemical acid fpirits, the blood is driven •along with the force of the poifon to the heart itfelf. But when, from this caufe, the brain is affedted with the narcotic virtue of opium, and the inteftines and ftomach with the virtue of purgatives and emetics, this is a de- monflration that the blood, with which thefe fubftances were mixed, had paffed through the ramifications of the veins to the heart, and from thence through the whole body. 69. Another proof we have in the transfufions of - blood ; in which all the vital gore from the arteries of one animal is urged into the veins of another exhaufted of blood, whereby the heart, arteries, and empty veins of the latter become fo turgid and well replenilhed, that they work the whole machine of the animal with a remarkable degree of vivacity, or even caufe it to la- bour by a plethora. 70. But that the blood pafles from the leaf! arteries into the lead veins, we are clearly taught by anatomical injedion ; where, by one arterial trunk, we eafily fill all the arteries and veins, almoft throughout the whole bo- dy ; provided the liquor be watery or very fluxile, fo as to pafs eafily in the veffels of the head, mefentery, heart, and lungs. 71. Laftly, the 7 mcrofcope has put the matter beyond all doubt in the pellucid tails, feet, and raefenteries, of animals ; where we fee, that the blood, brought to the extreme parts by the arteries, is poured either into fmali veins, continuous with the refiexed artery, or elfe goes through branches of the arterial trunk into the parallel communicating vein, by which it goes on to the parts neareft the heart. This is the way in which the blood pafles, as well into the lead: veins, which are capable of receiving only one globule, as into thofe that are fome- what larger, being able to admit two or more globules to advance forward in a bread. Bat, that there is no fpongy 32 CIRCULATION, kc. Chap. IV. fpongy or parenchymous interpofition betwixt the ar- ' teries and veins, in the general courfe of the circula- tion, is proved both from microfcopes and injections. For, if there w^ere any fuch parenchyma or fpongy inai's betwixt the arteries and veins, the hardening injections would fhow it, by appearing extravafated in a like un- fliapen mafs. 72. The circulation of the blood is, therefore, now received as a medical truth by every one ; namely, that all the blood of the human body is carried through the aorta, from the left cavity of the heart, to the extreme parts or converging ends of the arterial branches ; from whence the whole mafs is again tranfmitted into tlie lead veins, which convey it to the larger, and from them into the cava and heart itfelf ; in which courfe it perpetually goes and returns during life. 73. Yet there are fome inftaiices where, by pallions of the mind, a fudden revulfion by copious blood-let- ting, or a vafcular convulfion, the blood has been forced to recede back from- the fmaller into the larger arteries. And, on the other fide, where an obflrudtion being formed above the valves, the blood has been known to Aide back from the venous trunks into their fmaller branches. But then thefe accidents are very momen- taneous or fudoen, nd the blood foon returns into its natural courfe. Thefe things happen mod frequently in the abdomen and vena portarum. 7q. The courfe of the humours in the lymphatic veins which have valves, appears both from the nature of thole veins, and from ligatures ; for every lymphatic vein tied, fwells betwixt the fmaller extremities of it and the thoracic du£t ; but grows fiac-cid betwixt the faid duct and the ligature. All the valves in thefe, like thofe of the blood-veins, give a free pafiage for flatus and mercury to flow to the thoracic duct : but they make a refidance, and often an obdinate one, to any return the other way 5 although fometimes they have been known to yield. 75. The vapours that moiden the whole cellular fub- ftance, Chap. V. HEART. 33 ftance, the fleams of the abdomen and other venters, are ail thus drank up by the leafl pellucid veins, and fo conveyed along to the blood-veins, that their contained juices may pafs on to the heart : and from thence it is, that an oedema enfues when a vein is compreifed by a ligature ; becaufe, by intercepting the courfe of the ab- forbing veins by the ligature, the vapours ftagnate un- abforbed. In the other fmaller veffels, we can make no experiments : but they appear conformable to what we have faid, both by reafon and analogy ; and are like- wife fupported by the experiments of water or other li- quors, abforbed out of the cavity of the inteftines, tho- rax, and pulmonary veficles. 76. All juices, therefore, in the human body, are drove out of the heart into the aorta ; from whence they are all returned again to the heart by the lead veins ; thofe humours only excepted, which are exhaled or difcharged without fide the cavities of the body. To complete this circle, it only remains for us to find out a courfe for the blood, from the right to the left cavities of the heart : but then this fuppofes us to be firft ac- quainted with the hiftory of the heart, and the pulmo- nary veffels. CHAP. V. Of the Heart. 77. ^ I H E fabric of the thorax^ compofed of bones X and cartilages, in general refembles a trun- cated cone, as we (hall hereafter declare more at large. The lateral parts of this cone are two membranous bags, terminated above by an obtsfe end at the firft rib, where they lie very near together, and are diftinguifli- ed only by the interpofed cellular fubftance. The ob- liquity of the plane, dividing thefe two bags, is fuch, that the right is much the broadeft, and adheres in its defcent all along to the whole middle of ths fternum ; F butj 34 HEART. Chap. V. but, in its defcent, is inclined to the left fide, and comes from the margin of the fternum itfelf; while the left bag defcends, not from the fternum, but from the car- tilaginous ends of the ribs. The inner central fides of thefe bags, oppofed one againft the other, make up what anatomifts call the mediaftinum. Thefe bags have no where any communication one with the other ; fo that the right may be opened, and the lungs therein may be .deftroyed, without injuring the left. But the fimple denfe membrane, which forms thefe bags, out- wardly invefled with the cellular fubflance, is called the pleura ; being harder than the peritoneum, efpecially where it adheres to the back ; but is fomewhat fofter in its fore part, and is ahnoft deftltute of feeling. The capacity of the mediaftinum, or that interval which lies betwixt the right and left bag, broadeft above, and likewife below, contains the thymus, and fome conglo- bate glandules, fat, and veffels, and, in fome difeafes, pus. 78. Below, the fame bags, growing broader, depart one from the other, and leave a capacity through the whole middle part of their extent, by which the faid bags are divided one from the other. And this capacity is that of the pericardium. But the bags of the pleura on each fide the pericardium, defcending both before and behind it, terminate finally on the diaphragm, a- bout the fifth or fixth rib ; and on this their bafe is cut off obliquely, fo that each cavity is before fhorter in the fore part, as behind they defcend longer and lower, in fuch a manner as to be hollow in the upper part. With- in thefe bags, then, play the dilatable lungs. The back parts likewife of thefe bags are more tender ; and tho’ they ly near to each other, are yet feparated by the cel- lular fubftance, which terminates in the pericardium, and includes the aorta, together with the oefophagus ; and this we call the pojlerior mediaflinum. The trian- gular produdions of the fides of the mediaftinum form the ligaments of both lobes of the lungs. 79. The pericardium.^ or third bag, which firft the cellular Chap. V. HEART. 35 cellular fubftance, and then the conjoined pleura, loofe- ly cover on all fides as an outer coat, touches the fter- num indeed but by a very fmall part ; Imce the lungs, when diftended, cover the heart almoft wholly before, and interpofe betwixt the fternum and pericardium in their lower part ; and the mediaftinum, gradually de- parting towards the left fide, forms altogether a narrow interval under the lower end of the thymus, clofe to which the lungs meet on each fide : but this vital litu- ation you will alter or corrupt, unlefs you are very care- ful in your manner of opening the thorax. The peri- cardium has a broad, but fomewhat rounding, bafis, adhering to the tendinous part of the diaphragm, and by a fmall part to the flefhy fubftance of the fcptum on the left fide, about the fifth or fixth rib. In young fub- jeds it adheres more laxly ; but, in adults, very firmly, by the cellular fubftance fpreading broader to the right, and narrower towards the left. It is fom.ewhat larger than the heart; which, therefore, may move freely therein. This membranous' capfule, or fence of the heart, was never known to be abfent. 80. Upwards the pericardium grows gradually nar- rower, ending above the heart in an obtufe conical ap- pendix, extended over the coats of the large blood- veftels almoft to the upper edge of the fternum. It adheres firft to the inferior branch of the right fupe- rior pulmonary vein ; then to the vena cava ; after that to the aorta, on its acceflion to which it rifes high- er up ; then it adheres to the defeending trunk of the fame veflel, and to the duftus arteriofus ; from hence it is fpread upon the left branch of the pulmonary artery, then on both branches of the left fuperior pul- monary vein. On the back part it is again attached to the right pulmonary vein ; then to the left finus, to both pulmonary veins on the left fide, and to the auri- cle of the fame fide ; from thence it proceeds a long Avay from the pulmonary vein even to the inferior ca- va, then to the feptum of the finufes, then to the in- ferior cava. Befides, it goes to the pulmonary arte- F 2 ry, H E A R T. Chap.V. ry, its right branch, and the aorta under the origin of the large branches, in fuch a manner as to furround both arteries with a cylindrical production of its fub- ftance, whence it appears like a kind of partition be- tween every two neighbouring veffels. Thus alfo it contains the vena cava fuperior as in a ring, the ante- rior and pofterior cavities of the pericardium being freely continued between that vein and the aorta. In like manner it furrounds the inferior cava. But this flieath, by which the veffels are furrounded, preferves its nature only for a fliort fpace, and immediately re- turns to the heart with thofe large veffels to which it ferved as an external coat. It alfo fends a cellular fa- bric like a Iheath, along with the great arteries and veins, to the lungs. 81. The arteries of the pericardium are either from thofe of the thymus, which accompany the upper and lower phrenic nerves, or from the larger phrenic arte- ries, from the branches of the mammaries and media- ffinals, the bronchial, oefophageal and pofterior me- diaftinal arteries, or from the coronaries which inofcu- late with the bronchials and others. The venous trunks of the pericardium have a like origination, but appear with mofl evident anaftomofes from thofe of the right into the others of the left fide. The nerves of the pe- ricardium are from the fuperficial branches of the car- diacs. 82. That which makes the proper fubflance of the pericardium, is a ftrong, white, compact membrane, more robufl than the aorta itfelf, through which the nerves of the heart and fome fmall veffels defeend. Its outer furface, being fpread with the cellular fub- flance, gives it there a foraewhat rough appearance, while internally it appears highly poliflied, and nioi- flened on all Tides by a watery vapour. This vapour, which we have, times without number, obferved in the living animal, compofes fome, though naturally a very fmall quantity, of a water within the pericar- dium j which is either limpid, yellowiff, or reddifh, Chap. V. HEART, 37 and fubvifcid or gelatinous ; by difeafe, it is fometimes increal'ed to an immenfe quantity ; yet the exillence of fuch a water here is injudicioufly denied by fome. The water of the pericardium is of a lymphatic na- ture ; becaufe, by the heat of fire, it hardens into a jelly ; and from hence finall fibres and a cellular fub- fiance are often found, in fome difeafes, mixed with the natural vifcous humour which every where exfudes from the heart and its pericardium. This liquor is fe- parated, without any intermediate glandules, or any vi- fible pores, from the fmall exhaling arteries of the heart, auricles, and pericardium ; as may be proved by a fimilar tranfudatjon of water or filh-glue injeded into the large arteries. 83. The uje of the pericardium is to contain the heart, along with this vapour ; and to fupport and ftrengthen it as a fulcrum or prop, that, in contradion, the fibres of the heart may be drawn together without diftorting the large blood-veflels, and that it may lefs fluduate like a pendulum every way by altering the pofi- tion of the body. For thefe reafons, we find it in all ani- mals that have a true heart. A watery vapour here be- dews the heart, hotter and quicker moved than other parts, fo as to hinder attrition and cohefion betwixt it and the pericardium ; but, when this vapour is dried up or deficient, the pericardium adheres either to fome one part only of the heart, or to its whole furface, fo that it fometimes feems to be entirely wanting. 84. Nature hath given a heart to moft animals, even to many infeds and worms ; to others ftie hath denied it ; and thefe are the moft fimplc of all animals, although large, feeing they are irritable throughout their whole body, as, for inftance, the prickly hydra. To thofe animals who have no heart, veftels are alfo denied. 85. The veins which carry back the blood from the whole body to the heart, if we except thofe of the lungs, are reducible to two. The cava is improperly named in the fingular by anatomifts, fince it is no where, or for a very fhort fpace, one fingle trunk. The 33 HEART. Chap. V. The lower of the two large veins, which is the biggeft of them in man, afcends immediately above the dia- phragm Irom the right fide, towards which it is a little convex or gibbous, to its union with the upper cava, and, together wdth that in its back part, forms a mid- dle partition betwixt the right and left finus ; but the left fide of the venous tube degenerates into the right auricle, whofe fibres are a continuation from thofe of the cava. What we have here faid of the lov/er cava is alfo true of the upper. 86. Thus, by the meeting of the upper and lower cava, a finus or cavity is formed with a convexity to the right, and inwardly filled with ftrong, flefhy fibres, detached betwixt the two finiple membranes, and va- rioufly interwove. But the fame cavity, to the left and fore part, dilates forwards into an almoft perpendi- cularly oblong or oval form, and terminates above with a blind-pointed end, which is free from adhcfion with the heart, and lies incumbent on the great artery. This cavity alfo, like the former, has plenty of flefhy fibres placed betwixt two very thin membranes, almoft in a parallel pofition ; and thefe form a kind of arch extended from the right to the left edge of the w hole cavity, and round the anterior half cylinder of this cavity; and thefe mufcular arches are connected toge- ther by fome of the leaft fibres. This anterior and ftringy part of the cavity is called the auricle ; but that to the right and poftcrior part is called the finus: it is thin at the partition of the auricles, and likewife be- tween the oval ring and where the vena cava enters the heart. In this appendix there feem to be three large mufcles, the anterior, poflerior, and inferior. 87. In the partition which feparates the two auricles, the bafis lying in the middle between the two venae cavte is depreffed to the left fide, more on the upper, and lefs on the under part; and, at its bafis, the par- tition is exceedingly thin. Ifliall call it the oval fojfa. It is bounded on both fides by a flefhy column, by the union of which an arch is formed at top, while the thinner parts at bottom are turned backwards to meet one Chap. V. HEART. 39 one another. This I call the oval ring ; others, the ijlhmus. 88. Where the lower cava opens into the right au- ricle, from the tumid column of the left fide of the fo- ramen ovale arifes a moon-like membrane, naturally complete in its figure, and from its thinnefs in adults fometimes net-like : and this being extended round the lower edge of the auricule, grows thinner all the way as it is incurvated to the right; but does not quite fur- round half of the auricular circumference, the cavity of which it fervesTike a partition to divide from the vena cava. This is called Eujlachnis’ s valve. The oval foramen we (hall deferibe hereafter. 89. The blood of the two venae cavae is propelled by a mufcular force, in either vein, into this atrium or porch of the heart, compofed of the finus and auricle. Thefe veins, as far as they lie within the breaft, are endowed with flrong and irritable mufcular fibres, by whofe con- tradlion the blood is driven into the neighbouring auricle. 90. In like m.anner, the auricle, being irritated, is con- traftedonall fides. And firft,by aconffriftion of its muf- cular fibres, the anterior femicylinder of the auricle is reduced to a plane ; while the fame fibres, by their con- tradion, bring back the middle arch towards the ante- rior extremity or beginning of the heart, and likewife towards its poflerior extremity or finus. • Then the ap- pendix to the auricle defeends, and is contraded tranf- verfely by itfelf, while the lower part afeends ; and thus the auricle becomes fhorter. Again, the left edge turns evidently to the right, and the right edge a little to the left ; and thus the auricle is rendered narrower. Thus the blood of both cavse, being mixed toge- ther in the beginning of the heart now difincumber- ed, is drove through the edges of the open valve, in fuch a manner as to urge the valves of the right ven- tricle clofe to the fides of the heart. But the blood is now hindered from returning again into the lower ca- va, both by the contradVion of the auricle, the re- fiflance of the fucceeding blood from the abdomen, and HEAR T. Chap. V. and of the Eujlachian valve ; and upwards it is hinder- ed from afeending, both by the motion and weight of the confequent blood. Jt is driven back, however, on both fides, if there happens to be any oblfacle in the lungs. 91. The figure of the heart itftlf, in fome meafure, refembles half a cone, if the cone be fplit into two longitudinally in the dlreftion of its axis. It is almofi: triangular ; only the end of it is obtufe, and the lower fide of it is flattened in proportion to the diaphragm on which it lies incumbent, and is thereby fuftained. But the convex furface of the cone is fo inclined within the pericardium, under the great blood-velTcls, as fuf- fices to place its thicker femicircular curvature, which modern anatomills call its obtufe margin^ diredted to the upper and to the left fide of the breah ; in its lower and anterior part, the heart is alfo extenuated into a kind of edge, which is called its acute margin ; but the point is turned a little forewards. This is the general fituation of it in mankind ; but, in brutes, the heart be- ing almoft parallel to the larger axis of the thorax, its apex or tips only extend to touch the diaphragm. 92. The whole heart is hollow, having its anterior, formerly called its right ventricle, communicating into the right auricle and fmus, which is broad, and Iha- ped like the fourth part of a cone ; not fo long as the pofterior left ventricle, but larger ; and it terminates in the fliorter tip of the bifurcated apex of the heart. The mouth of this ventricle, where it opens into the auricle, is elliptical ; and terminated by a white gluti- nous margin, more callous than tendinous : over this, plates of mufcular fibres are fpread, and fome fat lies outw'ardly upon thefe. 93. From this callous margin is extended, within the heart, a membranous ring, formed by a reduplication of the internal membrane of the auricle, extended fo as to float wdthin the ventricle, to which it was before continuous. But this fame ring, in that part which fluctuates in the ventricle, is fo fplit or divided into three HEART. Chap. V. 41 three unequal triangular portions, that you may, in fome meafure, give them the name of valves, and count three of them in number, although they are, iii faft, only continued parts from one broader ring. Thefe were, by the ancients, named triglochines, or tri^ citfpid valves. 94. That part of thefe valves which lies next to the fides of the heart is ftrengthened by tendinous fibres, which, meeting together in their courfe, are inferted by very ftrong cords, partly into the fides of the hearty and partly into papillary or cylindric mufcles, which arife upward from the left fide of the right ventricle towards its right fide. The largeft of thefe mufcular columns is that which anfwers to the biggefl of the valves, which is both the uppermofl and that which anfwers to the adjacent mouth of the pulmonary arte- ry. The lead: of them is the loweft, and is fituated before the acute margin. 95. The ufefulnefs of this valve is evident enough * for the right auricle (90.) being contraded, the blood contained in the right porch of the heart, at the loofe ex- tremity of the auricle, being impelled from the circum- ference towards the axis, like a wedge, feparates the pendulous portions of the ring, called tricujfid valves, and preffes them to the fides of the heart. Thus is filled the right ventricle of the heart, while the upper- moft valve (94.) fhuts the pulmonary artery,' left the blood, by the weak impulfe of the auricle, fliould flow into that artery ; the blood thus received, and con- fined within the right ventricle of the heart, is, by the ftrong contradion thereof, more powerfully expelled into the artery. 96. The fenfible flefh of the heart, being irritated by the quantity and weight of this warm blood, is thereby folicited to a contradion : for that the heart, being irritated, will contrad itfelf in a perfon dying, or even lately dead, is proved by injedions of water, and inflations of air, whereby the heart, then quiefeent, is recalled to its motion. 97. The G 42 heart. Chap.V, 97. The heart’s motion is performed by mufcular fibres ; the originations of which, in genera!, are from rings formed of the cellular fubftance, compared into a callous ligament, agreeable to the defcription given in 92. and with which all the larger blood-veffels, at their opening into the heart, are furrounded. From thence the fibres which arife defcend gradually in an oblique winding courfe towards the left fide, and for- ward to the apex, in many diftindf plates, and fome- times a little traverfing each other, the middle ones being the mod tranfverfe, while the outermofl and in- nermoft defcend in a flraighter line. In the flat fide of the heart (91.) there are few fibres; and fo thin, that, when you have removed the fat, the cavity ap- pears almofl: uncovered. That which is called the left ventricle is, however, very firmly invefted by the fibres ; which, after furrounding the fame ventricle, form a flight decuffation in the feptuin cordis with the fibres of the right ventricle, and are interwoven with them. Some of thefe fibres defcend into the cavities of the ventricles, and form there the flefhy columns mentioned at 94. Others, at the tip of the heart, are wound in a vortical or whirling pofition, the two horns ending by a ftrong fafciculus or bunch in each ventricle. A very thin and finooth membrane covers the external and internal furface of thefe fibres ; but the external membrane, efpeeially where it is fpread over the coro- nary vefiels, contains much fat beneath it. I have, for my own part, not been able to diflinguifh any thing more particular in the mufcular fabric of the heart, with any tolerable degree of evidence ; becaufe it is the peculiar property of the fibres in the heart to join together in branchy appendices or heaps, in fo flrict union, that they cannot be feparated without lacera- tion. 98. But there are feveral eminent anatomifls, whofe ingenuity and communicative freedom I refpect, who have reprefented apd deferibed thofe fibres difplayed and feparated : namely, the external fibres of the heart. Chap. V, HEART. 45 heart, common to both ventricles, defcending to the tip, and then, taking another courfe, to infert them- felves into the feptum ; others again, at the tip, to perforate the left ventricle, and return, in a contrary courfe, to the bafis, along the inner furface of the faid ventricle. But the middle fibres, betwixt the afore- faid inner and outermoft ones, being varioufly inclined towards the bafis, they form the feptum. And others have given us figures and deferiptions of flill different orders of fibres, of which the outermoft run counter to the innermoft, while the intermediate are tranf- verfe. Which deferiptions, as they are not much dif- ferent from my own obfervations, I fliall make no op- pofition to, although I have never been able to fee this difpofition of them fufficiently manifeft, and am ac- quainted with great anatomifts who have not herein been more happy than myfelf. 99. Thefe fibres of the heart, like other mufcles, are furnifhed with nerves of their own, very numerous and of various origin. The fir ft and uppermoft are on the left fide from the ganglion of the intercoftal with the uppermoft cervical nerve. With thefe are joined others from the pharyngeal plexus of foft nerves ; others, produced from the pharyngeal and gloifo-pharyngeal ganglions, are mixed with them ; others alfo are added from the trunk of the intercoftal nerves ; and others from the middle ganglion feated on the ftraight mufcle about the paffage of the thyroid artery, which has branches both from that uppermoft nerve, and from the trunk of the intercoftal and phre- nic nerves. Others come from the recurrent nerve of the eighth pair. The nerves of the heart, originating from thefe fources, (wove together into a plexus, part- ly before the great arteiy, in which the following ones are mixed together; and partly forming feveral fmall plexufes between the afpera arteria and the large arteries going out of the heart,) form one or more plexufes out of the nerves of the right and left fide ; which plexufes are G 2 commonly 44 HEART. Chap. V. commonly joined together, though fometlmes they arc diftinft. From this fame plexus, or plexufes, other nervous twigs pafs betwixt the aorta and pulmonary artery to the right artery of the heart ; others crofs the pulmonary artery, and go betwixt it and the left auricle to the coronary artery of the fame fide ; others behind the pulmonary artery to the fame coronary ; and others, again, defccnd very deeply behind the pulmo- nary artery to the left finus and flat furface of the heart. To the cardiac plexus, above defcribed, other large nerves accede from the fifth and lower cervicals, and fometimes from the phrenic nerve, and from a gang- lion of the lowefl: cervical with the intercoftal, to w hich join large roots from the lowefl; cervical nerves. The lafl; defcribed nerves, which are larger, fofter, and more tranfverfely difpofcd, are partly mixed with the foregoing plexus, and partly go to the lungs. Laftly, there are fome fmall branches, uncertain as to courfe and number, which join the cardiac plexus from the recurrent and eighth pair of nerves ; and, making various inofculations with the intercoflals, are confounded with thofe of the eighth pair. As for thcfe nerves^ which fome enrinent anatomifls have feen afcending from the great abdominal plexus to the heart, through the foramen of the vena cava, I have, never been able to find fuch ; although it is eafy enough to difcover the diaphragmatics in that place, having ganglions pe- culiar to themfelves, of which thofe anatomifls make no mention. 100. That thefe nerves conduce powerfully to move the heart, is the opinion of eminent anatomifls, from a confideration of the common nature of mufcles; and from the increafe which follows in the heart’s motion, by irritating the eighth pair of nerves, either at the brain, or the fpinal medulla ; and from the languors that enfue upon tying thofe nerves, which proves fatal, either fuddenly or within a few days, even though you happen to make the ligature on but a few of the nerves that com^ to the heart j for the intercoflal, and efpe- cially Chap. V. HE AR T. 45 dally thofc from the ganglion of the upper thoracic, cannot be tied. 10 1. But that there are flill other caufes, befides that of the nerves, conducing to the motion of the heart, we are perfuaded from obferving its motion un- difturbed. by the irritation of all the nerves in the living animal ; from its remaining after the greateft wounds of the head, and even of the cerebellum and medulla fpinalis ; likewife from its motion w'hen torn out of the bread ; moftly in thofe animals in which the lungs, be- ing impermeable, make no refiftance to the heart’s mo- tion ; for the motion of the heart is obferved to be ve- ry vigorous in the foetus before the brain is well form- ed, and likewife in animals wanting the head. And all our experiments agree in this, that the quiefcent heart, in dead or dying animals, when irritated by heat, cold, vapours, poifons, and efpecially the force of impelled flatus, watery liquors, wax, or blood, or on receiving an eledric fpark, immediately contrads itfelf, by putting all its fibres into a rapid motion, by a force fometinies common throughout the whole heart, and fometimes affefling only a particular part of it. 102. Thus then we fee, that there refides in the heart a kind of impatience of ftimulus ; fo that even in the vifcus, when almoft dead, wrinkles, and motions of dif- ferent kinds, appear to be propagated along its furface, from places as it were irradiating from points : again, the heart, when torn out and cold, on being pricked, inflated, or irritated, contrails itfelf; and its fibres, when diffedled, corrugate themfelves orbicularly, when there is neither nerve nor artery to bring it fupplies of any kind. This irritability is greater, and remains longer, in the heart than in any other part of the body ; feeing, by Simulating it, the motion of the heart may be renewed at a time when that of no other mufcle can. The heart of the foetus is moft irritable, as well as larger, in pro- portion, than in adults ; and moft tenacious of its mo- tion, even in the cold. That motion is peculiar to the heart itfelf ; coming neither from the brain, nor the foul 5 4^ HEART. Chap. V. foui ; feeing It remains In a dead animal, even when the heart is torn out of the breaft ; neither can it, by any a£l; of the will, be made either quicker or flower. log. It is, therefore, evident, that the flimulus, oc- cafioned by the impulfe of the venous blood, caufes the heart contraft itfelf ; and that this contraftion is con- vulfive, made with great celerity, and a manifeft cor- rugation of the fibres ; whereby the whole heart be- comes fhorter, thicker, and harder, fo that the left ventricle is drawn fomewhat towards the feptum of the heart, and the right one much more. The bafe alfo advances towards the apex ; but the apex more evi- dently towards the bafis. This -I have often obferved with the greatefl certainty in difl'ecting brute animals ; fo that thofe learned gentlemen muff have feme w'ay or other been deceived, w'ho have afl'erted, that the heart is elongated during its contraftion. But the heart does not feem to turn pale in fuch animals as have warm blood. Even the feptum of the heart is rendered fhorter, and draws itfelf towards the bafis. By this aftion, the flefhy parts of the heart fw'ell inwardly, and comprefs the blood, as they do the finger, when introduced into its cavities. But that the heart is confiderably enough emptied in this adion, appears both from the event ; the evident palenefs of animals whofe heart is white, as frogs and chickens ; and from the internal furface being full of eminences, which exadfly anfwer to oppofite cavi- ties, and to the thick reticular arms or columns inter- rupted by finufes. Finally, the apex of the heart, be- ing contrafted a little like a hook, ftrikes againft that part of the pericardium next the thorax. Forwards, there is alfo a pulfation from the left venal finus ; which is, at ^hat time, particularly filled. In exfpiration, the heart flrikes violently more upw'ards and forwards. The truth of both thefe we know^ by experiment. 104. The blood, wdiich is prefl'ed by the contracted heart (log), endeavours to efcape in all diredlions ; but being driven from the mufcular Tides, tow^ards the axis of the ventricle, by the reaftion of what is lodged be- twixt Chap. V, HEART. 47 twixt the venal ring (93 .) and Tides of the heart, the loofer ends of the faid ring are driven forwards and extend- ed inward at the fame time. By this action upon the whole circumference of the ring,, it not only becomes extended itfelf, but, at the fame time, throws back a part of that blood into the right auricle whicli had before defcended into the cone of the open valve, whole fides, now approaching, (hut up the venous ori- fice more dofely as the heart contrafts more ftrongly, by whole force the tricufpid valves, as they are called, would be preffed reduplicated into the auricle, if the mufcular nipples (94.) or columns did not keep down their edges, and hold them firmly by their contraftion (which is the fame with that of the heart) in fuch a fhape, as will extend the annexed chords of the valve, without injuring them. 105. But the nifus of the remaining blood, now re- filled by the tricufpids, feeks another courfe ; and, whilfl it derives the larger of thofe valves that is feated to the right (94.), from the fide towards the axis of the heart, this leaves open the mouth of the pulmonary ar- tery, which it before coverfed ; whereupon the blood prefling the valves in the mouth of the faid artery clofe to its fides, it thus rufhes into it. 106. To defcribe this more particularly; from the up- per and pollerior part of the right ventricle, a way leads into the artery, taken in as it were between the flefliy parts of the heart produced, and ftrongly connected to it by a cellulous, callous ring, from whence the artery afcends to the left backward, and difplays itfelf behind the arch of the aorta. The ftrength of this artery is not extraordinary, being much weaker than that of the aorta. But from the inner furface of the artery, where it is joined to the heart, three femilunar valves arife, by a reduplication of the arterial membranes extended up- wards, and towards the axis, in an arch that is flat or obtufe enough ; and thefe valves always ftucluate with their edges at free liberty, in a parabolical fhape. The middle of the edges, in each of thefe valves, is gene- rally 48 HEART. Chap. V. rally divided, fometimes in the foetus itfelf, by a fmall, denfe, callous body, of a conical fhape, but made up of inclined planes ; whereby each whole valve, in itfelf re- fembling an half-moon, is thereby again fubdivided into two lefs half-moons. Betwixt the two membranes of the valve, appear fome mufcular or tcndmous fibres, partly in a tranfverfe pofition ; fome of which hold fait the valve to the next contiguous fide ot the heart, leav- ing fometimes fpaces betwixt them in a reticular man- ner. Other fibres afeend from the bafis of the valve j and, by growing to the callous corpufcle, draw back the laid valve, and open its concavity. 107. Each of thefe valves, in conjundion with the fides of the artery here diverging, intercept a fpace, which is blind or impervious downward ; but open up- ward in a parabolical fhape, as we obferved of the valves in the veins (49.) When, therefore, the blood is impelled from the fides towards the axis of the con- tracling heart, it endeavours to efcape in the diredlion of the faid axis ; and, by rufhing forth like a wedge, betwixt the valves, preffes their loofe fail-like edges againft the fides of the pulmonary artery, fo as to run freely out of the heart. The truth of this appears from the plain fabric, from injections, and from ligatures, which, by obflrudting the lungs, will not fulfer the large cavities in the right fide of the heart to be emptied. 108. The blood now received into the pulmonary artery, goes on then to make its circulation through the lungs. That artery is firfl: divided into twm branches ; of which the left, being lefs and fhorter, enters dircdfly into the fubflance of the lungs : but the right branch, being larger and longer, paffes tranfverfely through the arch of the aorta; and, after going a little way behind the faid aorta, enters the correfponding lungs of the fame fide. From each of thefe branches, by a multi- plied fubdivifion, arife the very lead arteries, fome of which tranfmit the blood directly into the continued fmall veins, and others exhale part of its aqueous juices into the pulmonary cells. That the blood goes thus di- reaiv HEART. Chap. V. 49 leQily from the arteries into the pulmonary veins, ap- pears evidently from their ftrufture ; alfo from a liga- ture, which, intercepting the blood’s courfe, while the heart and lungs flill urge it, caufes an aneurifmatic di- latation of the artery ; and from polypufes, by which, the mouth of the pulmonary artery being obftrudted, the right cavities of the heart become monftroufly en- larged, and at length burft, while the left remain empty. Laftly, from injeftions ; for water, fifh‘glue, and milk, are very eafily forced from the pulmonary artery into the vein, and from thence into the left cavity of the heart. But the diredt anaflomofes or final openings of the arteries into the veins in the lungs, is proved even to the fight by the microfcope, in frogs, &c. 109. Nor can the blood, which has once entered the pulmonary artery, return back again upon the heart ; becaufe the valves therein (106.) are of fuch dimen- fions, that, when diflended, they perfeftly fliut up the opening at the heart ; and are fo ftrong, that they refifl a much greater force than the contradion of the pul- monary artery, without being conftrained to yield. However, fometimes, from a greater contradile force of the artery, they grow fomewhat callous ; or, from a laceration of their outer membrane, a bony matter is poured in betwixt the duplicature of the valves. For, when the blood, by the contradion of the artery, re- turns towards the heart, it meets and enters the open fail-like concavities of the valves (107.), which are, by that means, expanded, and driven together towards an axis in the middle : whence the valves, once expanded, quite fhut up the mouth of the artery, fo as to leave not the lead flit open ; for any opening that might be left, is precluded by the fmall callous bodies remarked at 106. 1 1 o. The pulmonary veins ^ of which we lhall fay more hereafter, gather into larger branches, which, at laft, terminate in four (feldom two, and flill more rarely in- to five) trunks ; to which it has been cuftomary ta affix a name in the fingular, by calling them the pul- monary vein. Thefe enter the cavity of the pericar- . H dium. 50 HEART. Chap. V. dium, From whence they receive an external covering ; and are then inferted at angles into the fquare left or ■pojlerior finus^ which is fometimes likewife called the pulmonary finus. In this courfe the upper veins de- fcend, as the lower ones afcend. But that thefe veins bring their blood towards the heart, in the fame direc- tion with the fmus into which they open, is proved by a ligature, which caufes a turgefcence or fwelling, from the blood retained, betwixt the ligature and the lungs. 111. This pulmonary fmus, which is almofl of a cu- bical figure, being firmly built of divers bundles of fibres running betwixt two membranes, has, forward and to the right, one fingle fide or partition, in com- mon to itfclf and the right finus (86.); but, forward and to the left fide, it goes into a conical appendix, which is divided into proceffes, or indentations, like a cock’s comb ; and, after two or three ferpentine turn- ings, makes what is called the left auricle^ incumbent on the left ventricle, and pointing forwards. Some of its fibres, as in the right auricle, by their bending, con- traft it into the form of an arch ; others, coming from the origin of the appendix, and inferted into its apex, deprefs it. This finus, with the left auricle, are fome- what lefs than the right finus and auricle. 112. In this left finus, the blood waits for the heart’s relaxation ; at w'hich time the nifus of the blood im- pelled againft the venous valves, and the contrading Ilronger force of the finus, grow lefs. Then the left finus ftretches itfelf forward acrofs the heart, is contraft- ed tranfverfely along with it, and the appendix becomes evidently fliorter and narrower. Thus the blood is driven into the left ventricle, in like manner as the right auricle impelled its blood into the right ventricle, (95.) For here, as before, a like membranous oval ring forms productions called mitral valves, of which there are u- fually two only counted. Thefe valves are longer and Ilronger than thofe of the right ventricle. They have each a mufcular column, often fingle only, and joined to the tendinous threads of each valve : but they are much Chap. V. HEART. 51 much ftrongcr than thofe of the tricufpids. And here, more frequently than in the valves on the right fide, callous knots, or cartilaginous humours, are found in the tendinous ftrings, at their originations from the membranous ring. 1 1 3. From what has been faid, then, it appears, that the fame blood is now arrived into the left ventricle of the heart, which was a little before fent from the venae cavae into the right auricle (89.), which drove it into the correfponding or right ventricle (95.) ; by which, again, it was urged into the pulmonary artery (105.); and, from thence, palling into the pulmonary veins, was conveyed into the left fmus (no.); and, out of this, we here find it driven into the left ventricle (112.). This courfe of the blood, from one fide of the heart to the other, through the lungs, is called the pulmonary or leffer circulation, and was known to many of the an- cients. It is proved by the increafed bulk of the pulmo- nary veins on the left fide ; and likewife of the right cavities of the heart, on an obftrudion of the entrance into the left ventricle. 1 14. The left, or pofterior, and upper ventricle of the heart, which is always firft formed, and in a great number of animals the only one, makes up that part of its half-cone-like body, which we before called obtufe, (91.) It is fomewhat narrower than the right ven- tricle, a little longer, rounder, and generally of a lefs capacity within. For the contents of this ventricle are about two ounces, while thofe of the right advance up to three. Its fabric internally is reticular, but more nicely wrought than in the right ventricle ; and with- in the mouth of the artery it is fmooth : but irs force is confiderably greater, as the mufcular flefii that fur- rounds it is much thicker, and almofh three times ftronger. The feptum of the heart belongs moftly to the left, but fome part of it alfo to the right ventricle : the whole of it is reticulated in like manner ; but folid, and incapable of fulfering any injeded liquid to pafs from one ventricle to another. H 2 1 15. Again, 52 HEART. Chap. V. 1 1 5. Again, this left ventricle, being inftigated to motion by the impelled blood, does, from the fame ir- ritable nature before mentioned (103.) contraQ:, and drive its contained blood with a violent motion in the direftion of its axis, and determine it towards the bafis, at the time when the tip or cone of the heart is drawn nearer to its bafis. And fmce the apparatus of the mitral valves is here the fame as before in the tricuf- pids, the venous blood, now expanding the ring from w'hence they arif^, removes that valve which lay againfl the mouth of the aorta, fo as to open a way for itfelf to the artery ; in dilating the mouth of which, the faid blood preffes the femilunar valves, there placed, againfl the fides of the aorta, into which it rufhes with a vio- lent impetus. This is proved by ocular demonflration in living animals, where the left ventricle fwxlls upon fhutting the paffage into the aorta. 116. The femilunar valves of the aorta differ little from thofe in the pulmonary artery : only as the open- ing is here greater, fo the valves are propoitionably larger and flronger, and are not fo often dilUnguiflied in the middle by thofe callous globules or little round bodies. The fibres too of the valves, both tranfverfe and afcending, are here fomewhat more confpicuous. 1 1 7. After the contraftion of the heart, follows its rela- xation or diaflole, in which it becomes empty, lax, and foft, recovers its former length, the ventricles recede from the feptum, and the bafis from the apex. But, while it is in this (late, the blood in the auricles, having been as it were in a flate of expectation, rufhe s through the openings of the valves of the veins, dilates the op- pofite fides of the heart, and makes it at once longer and larger. After the auricles have freed themfelvcs of the blood they contained, they are in like manner relaxed, and their oppofite fides remove from each other. Then the blood, collected in the venm cavse and pulmonary veins, fills the auricles by the contraction of the veins ; renders them long, bread, and thick, like the ven- tricles ; and even di fiends and fills the tooth-like pro- cclfes Chap. V. HEART.. 53 ceffes of the crefted margin. That the fibres of the heart are not dilated, is proved from the jundfion of thofe fibres ; which, being tied together by their mid- dle branches, cannot be feparated : alfo, by the diffec- tions of live animals, in which the whole heart is fiiown to be contraded. 118. But we mufl; now confider, that thefe motions of the right and left auricle, with the right and left ven- tricle, are not performed in that fucceffion in which, for the fake of method, we have here defcribed them ; for both the auricles are contraded, while the ventricles are relaxed ; fo that the contradion of the auricles pre- cedes the contradion of the ventricles ; as we are af- fured from manifefl experiments on dying animals, and on thofe whofe living blood is cold. But both auricles are filled together in the firft inftant, as both of them are emptied together in the fecond inftant ; and both the ventricles, are contraded together in the third in- ftant, which is the fame with the firft ; and both ven- tricles, being evacuated, are relaxed in the fourth in- ftant, which is the fame with the fecond. Thofe who have miftakenly taught otherwife, have not taken the advantage of making a fufficient number of experi- ments on living animals. That the auricle, near death, makes frequent palpitations, before the ventricle of the heart performs one contradion, is true enough. The auricle wnth its finus forms one cavity, and both are fill- ed and both emptied in the fame inftant. I ip. But it may be afked, why the heart never ceafes from its perpetual motion, through fuch a number of years as there are in one’s life, through fo many days as there are in a year, and through, fo many hours as there are in a day ; when, in each hour, the heart of a healthy perfon contrads not much lefs than 5000 times; fo often are there fucceffive repletions followed with new contradions, perpetually in the fame conftant or- der. Nor is there any other mufcle, befides the heart and diaphragm, but what becomes tired and painful, by ading incelfantly, even for a few hours. Different anfwers 54 HEART. Chap. V. anfwers have been given to this queftion by different profeffbrs, founded either upon a compreflure of the cardiac nerves betwixt the large arteries, or upon an alternate repletion of the coronary arteries and cavities of the heart, &c. 12 0. But to me the fimplicity of nature feems very great in this matter. When the auricle is relaxed, it is diredlly filled by the mufcular force of the continu- ous great vein ; and fo the heart alfo contracts itfelf, when, in like manner, it is irritated by the blood driven into it from the auricle. Therefore, the heart, having once received the blood, is contraded by that ftimulus or irritable force, whereby mufcular fibres are excited into contradion *, whereupon it empties itfelf of the blood, and, being freed from the ftimulus thereof, im- mediately refts or relaxes itfelf. But the heart being now relaxed, the auricle is in like manner irritated by its contained blood, and by contrading fills it again ; while the inceffant adions of the heart and arteries con- tinually urge new blood into the right finus and au- ricle. That this is the true flate of the heart’s mo- tions, is proved from adual experiment or obfervation ; whereby we plainly difcern the fucceflive repletions and conflridions made in the great vein, auricle, ventricle, and artery, eafily feen in a weak or expiring animal j but more efpecially, and more evidently, in thofe ani- mals which have but one ventricle in the heart ; as the tortoife, frog, fnake, fiflies ; and in the chick hatching in the egg, which, inftead of a heart, has only one crooked canal. The fame is alfo confirmed from the refting of the heart, which follows upon tying the veins ; and from the return of its motion, by removing the li- gatures, or by the impulfe of wind or liquors injeded ; and, lafily, from the perpetual contradion of a frog’s heart, round or upon a veficle of air inflating it ; which air, urged into it by the veficle, it will alternately re- ceive, and for many hours tranfmit into the common air. The left ventricle firfl ceafes its motion ; then the auricle of that fide j then the right ventricle j after that. Chap. V. HEART. 55 the right auricle ; and, laft of all, the pulmonary vein$, and venss cavse. Whatever motion is in the vense ca- vae, ought to be attributed to the auricle repelling the blood into both thefe veins, and which the heart, when dead, is not capable of receiving. 121. Nor do I believe there is any thing more re- quired to the heart’s motion, than a continual ftimulus applied to a very irritable part. For, even in the ar- ticle of death itfelf, the very coldnefs of the limbs, which the warmth of life has left, contracts the veins, and. drives the blood to the heart ; when the lungs, being impermeable for want of refpiration, tranfmit no blood to the cavities of the left hde. And, on the other hand, the heart, after it is thoroughly emptied, re- mains at reft. It may thus happen, that, inftead of the vena cava and right auricle, the laft appearance of life may be transferred to the left auricle and ventricle ; if we fuppofe the right cavities to be empty, the left may be irritated by the blood contained in them. But if you derive the refting of the heart from the compref- fion of its nerves, the motion of the auricles will be an obje£lion, becaufe their nerves are not comprefled. An example alfo we have in filh, and little chicklings in the egg, where there can be no room for a compreflure of the nerves. If, again, you deduce the heart’s reft from a compreflure or occlufion of the coronary arteries, this is contrary to experience ; fince they are not co- vered by the valves of the aorta, and from a wound of the faid arteries, during the fyftole of the heart, the blood ftarts out to a great height. 122. Nor, with the ftrength of the heart, do I join the ofcillations of the very fmall veflels, which is refuted by experiments : nor the force of external heat ; feeing animals are found to live and thrive in the coldeft re- gions of the north : and though the contradlile force of the artery, and the weight of the parts and of the atmofphere, alTift the motion of the blood during the diaftole of the heart, the fame powers refill it during the fyftole j fo that, indeed, by thefe means, the blood 5^ HEART. Chap. V, is moved no farther through the contractile arteries, than even through the rigid arteries of the fmaller ani- mals. 123. But with what celerity, and with what force, the heart drives forward the blood, is controverted, and varioufly computed. The more modern writers have raifed their calculations upon a fuppofition that, for the celerity to be determined, we are to admit two ounces of blood to ilTue out of the heart with fuch a celerity, that the part of the pulfe, called its fyjlole, makes one third of the whole pulfation, and is hnilhed within a VTT part of a minute j but the area of the mouth of the aorta, they have eftimated 0.4187 parts of an inch : fo, by dividing the fpace filled by two ounces of blood, (3.318 inches) by the area or feftion of the aorta at its mouth, (^and length of its cylinder filled by two ounces, viz.=7ff^], the number thence produced divided by the time in which the heart contratfs, they find 149 feet and two tenths of an inch for the fpace thro’ which the blood runs in a minute, if it goes on in a cylinder with the fame velocity it firft had from the heart. But the incumbent weight of blood moved by the heart, they have computed by the jet wherein the blood (tarts forth from the larger arteries in a living animal, being feven feet five tenths; and from the furface of the ven- tricle, whofe area make 15 inches; which produce 1 350 cubical inches of blood, or 5 1 pounds five ounces, which prefs againfl the ventricle of the contracting heart. The heart, therefore, thus drives forward a weight of 5 1 pounds, with a velocity by which it may run through 1 49 feet in a minute ; which force it exerts four thoufand eight hundred times in an hour. 1 24. Although there are many particulars here un- thought of, which may render the eftimate incomplete, and l^uch perhaps as we may never get over ; and although the mouth of the diftended aorta may be wi- der in a living animal, though the area of the ventricle is of uncertain dimenfions, and the jet of blood com- puted from an infufficient height ; yet, if we confider Chap. V. HEART. 5? the violence with which the blood ftarts from lome of the lead; fanguine arteries in the living animal, although we cannot eafily determine how much of the heart’s fyftole it affutnes to itfelf, variations in which will great- ly alter the computation ; yet, in the mean time, it will plainly appear, that the machine we call the heart is a very powerful one. The truth of this is evident from experiments, in which it appears to be very diffi- cult to fill all the red blood-velfels by anatomical in- jedions, and quite impoffible to fill all the fmaller of them : yet the heart, we fee, not only gradually diflends all the larger, the fmaller, and even the lead veffels, with blood, but alfo drives it forward through them with a confiderable celerity. Even in the leaft arteries, the blood is urged forward by the heart with fuch a force as to make the alternate motions of that mufcle per- ceptible. Likewife, in the veins and fmaller veffels of cold animals, even while contained in the infcfts egg, there is no other force befides that of the heart, by which the blood is driven through their fmall veffels. And, from fome of the lead arteries, I have feen the blood dart forth feveral feet, the jet defcribing a para- bola, whofe height was four feet, and amplitude of the projefliion feven feet ; and fome affert, they have feen the blood afcend from the aorta to the height of twelve feet. 125. Moreover, that we may make a jud edimate of the heart’s force in living animals, we mud confider what great refidances that complex mufcle overcomes : we mud compute the enormous weight there is of the whole blood; a mafs, perhaps, of fifty pounds and npwards : for all that quantity of fluids, once dagnant in a perfon lately drowned or fainted away, are eafily put into their former motion by the heart only. We mud again confider the great decreafe of the blood’s velocity, arifing from the greater light or capacity of the dividing branches, (from whence the ratio of its ce- lerity, even in the intedines, may be computed to on- ly a 24th or a 30th part of its original impulfe), abates I two- 58 HEART. Chap. V. two-thirds from the heart’s force. And yet we fee there are humours fwiftly moved through much fmall- er velfels ; as, for example, in thofe of the Sancforian perfpiration, which, in a fubterraneous cavern, I have obferved to afcend fwiftly in form of fmoke or vapour ; and the fame celerity of the blood in the leafl veflels of little fifhes, &c. is apparent to the eye by a microfcope. Now, fince the fridions, in every machine, always confume the greateft part of the moving forces ; much more do they in the human body, whofe blood and juices are fo much more vifcid or clammy than water, and driven through' veifels fo fmall, that they permit only a globule at a time to pafs through, and even hardly allow that without changing their figure : but from fo ftrong and extended a fri£Hon there mufl neceffarily follow a very great hindrance to the motion ; whence we may eafily underftand, that the force muft be very great which drives fo fwiftly fuch a prodigious mafs of fluids over fo many refiftances and decrements of the moving forces. But aneurifms, andlikewife arteries, are burfl by the force of the heart ; and great weights are elevated along with the human body by the force of its fyftole. 126. The blood, being driven into the aorta, imme- diately finds the two openings of the coronary arte- ries, which lie next the arterial valves, but above them, or within the aorta ; and, in confequence of this, it ruflies firfl of all into the faid coronary arteries, by which the heart fupplies icfelf with blood. Thefe arte- ries are almoft conftantly two ; which going off from the aorta next the heart at an obtufe angle, the right goes off between the aorta and pulmonary artery, and the upper and left one between the left auricle and the aorta. All the external arteries are furrounded with much fat ; but their cavity is more intercepted with valves than that of other arteries. Thefe arteries com- municate, by inofculations of the fmall branches, every where about the feptum and tip of the heart ; but they no Chap. V. HEART. 5p no where make a complete ring round the heart. They terminate in a two-fold manner. 127. The firfl termination of them is into the coro- nary veins, whofe branches running in company with thole of the arteries, have their trunks of neceffity dif- pofed in a different courfe. The great coronary vein is, therefore, a companion of the left coronary artery ; and is inferted with a large opening, fecured with valves, or a number of little membranes, on the left fide of the Euftachian valve of the right auricle : the root of this furrounds the left auricle externally, and then accompanies the fuperficial branches of the left artery. 128. The other coronary vein (which you may make a part of the former, fince they have both one common infertion) defeends along upon the feptum of the heart to its flat fide ; and may be properly called the median coronary. The third bends tranfverfly round the furface of the right auricle ; and then terminates within, or at leafl; very near, the large opening of the edronary vein (i 2 7.) anteriorly. This vein fupplics that part of the right ventricle which lies in the flat fide of the heart ; and often receives thofe namelefs veins we fhall hereafter deferibe. 129. There are ftill fome other anterior veins of the heart ; but one, more particularly large, goes along the adjacent edge of the right ventricle, and, running for fome length obliquely betwixt the membranes, is inferted into the mofl: anterior part of the right auricle, and fometimes into the trunk of the upper vena cava. This anterior vein fends off another concealed one through the root of the right finus ; and, being again inferted into the great coronary vein, it makes a com- plete circle round the heart, like the arterial circle which fome have deferibed, but has not yet been feen by me. 1 30. But there are a great many more veins, un- certain in their number, which belong to the bafis and internal parts of the heart, to which the anatomift has I 2 feldona 6o HEART. Chap. V. feldom any accefs, becaufe they lie concealed betwixt the origins of the large veffels : and thefe open by num- berlefs fmall mouths into the right finus and auricle ; and fome, but a few only, into the left finus. Thus I have feen a particular vein, which, from a latent fi- nus in the flefh of the right auricle, has afcended to- wards the aorta and pulmonary artery, and inferred it- felf on one fide into the greater coronary vein. Ano- ther I have obferved, concealed betwixt the mouth of the coronary vein and the aorta, inferred into the right finus ; and another through the remains of the oval foramen, and feptum of the two finufes, inferring itfelf into the right finus ; and others again belonging to the venous valves ; befides which, there are ftill others too numerous to deferibe. I have obferved alfo a vein arifing from the left finus, and inferred into the vena cava. I 31. There are ftill more, and much fmaller, veins in the heart, whofe little trunks, being very lliort, can- not eafily be traced by diffeftion ; and thefe open them- felves by an infinite number of oblique fmall mouths, through all the numerous fovas or little finuofities and excavations obfervable throughout the furface of the right and left ventricle. Thefe are demonftrated by injedions of water, wind, or mercury, made by the coro- nary arteries, after you have firft tied their correfponding or accompanying coronary veins ; or even bv injecting into the great coronary veins, after you have firft inter- cepted the openings of their largeft trunks. For, in cither of thefe cafes, there are drops of the tinctured water, bubbles of air, fpherulcs of mercurv, rulhing out through the w'ho.le extended furfaces of both the ventricles of the heart: and this, without any violence that can be fuppofed fufficient to break the velTeis. But the paftage from the arteries into the cavities of the left fide is more difficult. 132. There are fome wdio will have the coronary arteries filled with blood, not by the contracting of the heart, but of the aorta in its fyftole ; which they think muft Chap.V. heart. 6 i muft be a confequence of the retrograde angle of the blood’s courfe here, and the palenels of the contraded heart, with a fuppofition that the valves of the aorta cover or clofe the mouths of the coronary arteries. But the two laft of thefe are difproved by experience ; and the firft, or retrograde courfe, can only impede or leffen, and not intercept, the flux into the heart : for the injeftions of wind or mercury, into all the fe- minal and biliary veflels, demonftrate, that the large retrograde angles, which the veflels often there make, do not hinder the fluids from taking their natural courfe, though they retard it. But a proof, ftill more evident, is, that the coronary artery has a pulfe at the fame time with all the other arteries in the body, and the blood darting from it makes a higher faltus at the time when the heart is contra£fing( 121.) 153. Concerning the reflux or return of blood from the mufcular fubftance of the heart, there is ftill lefs room to doubt : for all the coronary veflTcls difeharge their blood into the auricles and ventricles, either right or left, (but lefs into the latter), by thofe larger (127, 128, 129.), and by the fmaller orifices (130.), as well as by the leaft (131.), which fo eafily tranfmit the in- jections, after you have firft tied the larger coronary veins. The circulation through thefe veflels feems to be compleated in the ftiorteft fpace of time that can be in any part, from the great velocity the blood receives from the heart itfelf, urging the fame through its own fubftance. But that the whole contents of the veflels are cleared in each contraction, does not feem to me probable ; for the blood-veflels of the heart do not look pale enough in that aCtion to produce fuch an ef- fect as an entire evacuation. There is a very free or open paflage from the arteries of the heart into the cel- lular fubftance, or fat, which furrounds it. If you afk. What are the ufes of thofe leaft or ftiorteft veins which open obliquely through the furface of both the ven- tricles ( 1 3 1 .) ? they ferve to return the blood of thofe deeply 62 BLOOD. Chap. VI. deeply feated fmall arteries, which have no correfpond- ing veins. 1 34. The humours of the heart, which are thinner than blood, return by the valvular lymphatic ■veins, which accompany the coronary blood - velTels, and afcend towards the thoracic du6t and fubclavian vein ; but are very rarely to be feen, although 1 have obferved them in brute animals. CHAP. VI. Of the Nature of the Blood and Juices of the Human Body. 135. I ^ H E liquor which is contained in the beat- JL ing arteries and their correfponding veins, is called, by one general name, the blood ; which, to aloofe examination, appears homogeneous, or of fimilar parts, red and coagulating throughout ; and is obferved to be redder in proportion to the ftrength of the animal ; in a weak and fciinlfhed one, the blood inclines to a yellow : it hath a whitenefs mixed with it, which comes almoil totally from the chyle. But experiments of diverfe kinds have Ihown us, that diffimilar parts of various natures refide in the compofition of this animal liquor. 1 36. That fire is contained in the blood may be proved from its heat, which, in human blood and that of fome other animals, is from 92 to 100 degrees 01* Fahrenheit’s thermometer, more than the mean de- gree of atmofpherical heat, but lefs than the greateft. Again, a kind of volatile vapour or exhalation conti- nually flies off from the warm juice, with a fort of fetid odour coming betw'ixt that of thefweatand urine. This vapour, being catched and condenfed in proper veffels, appears of a watery nature, joined with a fmall tinfture of an alkaline difpofition. 137. After this vapour is gone off, the blood of a healthy Chap. VI. BLOOD. 6 ^ healthy perfon fpontaneoufly congeals into a fciffile trembling mafs j and, with a lefs degree of heat than that of boiling water, (viz. 150 deg.), it grows more tough, like to a boiled egg. This toughnefs is greater in feveriili perfons than in fuch as are in health. It forae- times coagulates in the veins of a living perfon, and is found clotted in wounds of the arteries. But even within the velfels of a living perfon, and in one dying of a fever, the blood has been feen, by the violence of that diftemper, changed into a concreted tremulous jelly throughout all the veins. The principal part of this coagulated mafs is the crajfamentum or cruor, which has the red colour peculiar to itfelf, and gives it to the other parts of the blood. This, if it be not kept fluid by the attrition of a vital circulation, or fome fimilar concuffion, runs confufedly into a compact, but foft mafs, like liver, merely by reft and a moderate degree of cold ; as it alfo does by the addition of alcohol, by mineral acids, or by a heat of 150 degrees, of which 98 is the blood’s heat in robuft people. It is, either as a fluid or a folid, fpecifically heavier than water by near an eleventh part j and, when freed from its water, it is wholly inflammable. In a mafs of healthy blood, one half or upwards is red cruor: and, in ftrong laborious people, the feruni makes only a third part ; and is ftill more diminilhed in fevers, often to a fourth or fifth part of the mafs. I 38. From this coagulum there feparates, at firft as it were fweating out of its pores, but which afterwards collefts in fufficient quantity to allow the concrete to fink in it, another white, fomewhat yellowifli, part of ,the blood ; which again feems to be a liquor, con- fifting of homogeneous or fimilar parts, when it is not really fo. This part of the blood is, in general, one thirty-eighth part heavier than water, and almoft a twelfth part lighter than the red globular mafs of craf- famentum: this too, by an heat of 150 deg. or by mix- ture of mineral acids or alcohol, and by a concuflive motion, is congealable into a much harder coagulum than 64 BLOOD. Chap. VI. than the red cruor (137.); and forms an undiflfolvablc glue, a flefli-like membrane, which at length fhrinks up to a horn-like fubftance, or friable gum. From thence are formed the pleuritic crufts or ficins, polv- pufes, and artificial membranes. In this ferum of the blood, befides the albumen, which will harden like the white of an egg, there is concealed a great deal of fimple water ^ which even makes the bigger part of the whole ; and fome quantity of a ropy mucus^ capable of being drawn into threads better than the red cruor ; which lafl, however, is not coagulable like the albu- men, neither by fire nor by acids. 139. But, by putrefaftion only, or the dilTolving power of the air hot to 96 deg. equal to the blood’s na- tural heat, the whole mafs, but efpecially the ferum, diiTolves or melts into a fetid liquor ; firll the ferum, and then the cruor more flowly ; till, at length, the whole mafs, both of ferum and cruor, is turned into a volatile and fetid exhalation ; leaving very few feces behind. The blood being a little diffolved by putre- faftion, and even before that, becomes fetid ; with the fetor, affumes an alkaline nature ; and eftervefees with acids. This property it afterwards lofes, the al- kaline fait being deflroyed by putrefaction. The pu- trid blood cannot by any art be infpifi'ated, as it is al- fo very difficult to be relblved after it has been coagu- lated by fpirit of wine. By too fevere exercife, heat, and malignant diforders, the cohefion of the blood is diffolved, and it affumes an alkaline nature ahnofi; as if from putrefaction. 140. Befides thefe parts of which the blood appears to confift, without fubjeCting it to any violence, it contains in its fubftance a quantity of fea fait, which is difcernable to the tafte, and fometimes vifible by the microfeope. That there is earth lodged in the blood, is demonflrated from nutrition ; and from a chemical analyfis, whereby the earth appears to lodge in the molt fluid, and efpecially in the oily, parts of the blood. By fome very late experiments, it appears, that a con- fiderablc Chap. VL BLOOD/ 65 liderable quantity of ferruginous earth, eafily reducible into metal by the addition of phlogifton, is contained in the blood when calcined. Laftly, another part in the blood is air in an unelaftic flate, and that in a very confiderable quantity 5 the exiflence of which air in the blood and feruin is proved by their putrefadlion and diftillation, or by removing the ambient air from them by the pump. But we are not to think, from hence, that the blood-globules are bubbles full of air, for they are fpecifically heavier than the ferum. 14T. By the admixture of neutral falts, the colour of the blood becomes deeper and brighter, as by them it is neither ditfolved nor thickened. It is fcarcely al- tered by a weak acid. By fermented liquors it is coagu- lated. Fixed alkaline falts have almoft the fame effedls as the neutrals. The volatile alkalies rather turn it brown, and coagulate it. Alcohol and diftilled oils coagulate it, as alfo vinegar. It does not effervefee with any fait. 142. Chemiflry has, by various ways, Ihowed us the nature of the blood. (i.)When frefh drawn, before it has time to putrefy, the blood, diftilled with a flow heat, yields a water to the quantity of five parts in fix: of the whole mafs ; which water has little or no tafte or fmell, till you come towards the end of the opera- tion, when it is proportionably more charged with a fetid oil, as it draws nearer to a conclufion. (2.) The refiduum, expofed to a ftronger fire, yields various al- kaline liquors ; of which the firft, being acrid, fetid, and of a reddifh colour, is ufually called the ffirit of blood ; confifting of a volatile fait, with fome little oil, diflblved in water, to the amount of one twentieth part of the original mafs of blood. There is an acid obfer- vable in the fat, and likewife in putrid flefh and blood. (3.) A little before, and together with the oil, that next afeends in the diftillation, a dry volatile fait arifes, and adheres in branchy fleeces to the neck and fides of the glafs ; and this in but a fmall proportion, lefs than an eightieth part of the firft mafs, (4.) The next K liquor 66 BLOOD. Chap. VI. liquor is that called oil of human blood, which afcends gradually thicker and heavier, is at firft yellow, and afterwards black, till at lad it refembles pitch, being very acrid and inflammable, but in a fmall quantity, about a fiftieth of the whole mafs. (5.) There now re- mains, in the bottom of the retort, a fpongy inflammable coal or cinder of the blood, which, being kindled, burns away, and leaves aflies behind. From thefe, by lixi- viation with water, is obtained a mixed fait, partly fea- falt, and partly fixed alkali, together with a fmall quan- tity of fixed earth. This fixed fait is fcarce the five hundredth part of the firfl mafs, and of this only one fourth part is alkaline : but, being urged with the mofl intenfe degrees of fire, the whole fait affords fome por- tion of an acid fpirit ; which we judge to arife partly from the fea-falt in the blood, fome of which isdemon- ftrable even in the fpirit of blood ; and partly from the vegetable kind of the aliments, not yet digefted into an animal nature. For which lafl; reafon, an acid is pro- curable from the blood of graminivorous animals, as well as from that of man. But the earth, feparated from the lixivium by filtration, will, perhaps, make a- bout an hundred and fiftieth part of the original mafs ; and contains fome particles which are attrafted by the loadflone. 143. From the preceding analyfis of the blood, it evidently contains a variety of particles, difiering in bulk, weight, figure, and tenacity ; fome watery, others inflammable, and mofl; of them inclined greatly to putrefaciion or to an alkaline nature. For the blood, in a found healthy flate, not injured by putrefadlion, or too violent a degree of heat, is neither alkaline nor acid ; but mild or gelatinous, and a little faltifh to the tafte : yet, in fome difeafes, it is fliarp enough, and comes near to a flate of putrefaflion ; as, for inftance, in the feurvy, where it corrodes through its containing veffels ; and in dropfies, the waters of which are often next to alkaline. But the calx of the blood of infers is alkaline, and effervefees with acids. By Chap. VI BLOOD. 67 1 44. By viewing frefli blood in a fmall glafs tube by a microfcope, or by applying the fame inftrument while it is yet moving in the veins of a warm living animal, as a hen-chicken, or a cold one, as a frog, we perceive in it red globules ; which, doubtlefs, make that part called cruor or craffamentum, mentioned in 137. If it be queftioned, whether thefe are not rather lenticular particles of the fame kind with thofe obferved by Lew- cnhock in filh, and lately difcovered in our own fpecies ; we confefs it is a point difficult to ’determine : nor have I ever made a fufficient number of microfcopical expe- jiments on thofe globules which feem moft denfe and convex. 145. The colour of thefe globules is red; and fo much the deeper, and more inclined to fcarlet, the ftronger the animal is : and, in the fame proportion, their number increafes, when compared with the quantity of yellow ferum. Their diameter is very fmall, being be- tween and of an inch. They are faid to change their figure into an oblong egg-like ffiape, which I could never obferve with fufficient certainty. They are alfo faid to diflblve into other leffer globules of a yellow colour, which I have neither obferved my- felf, nor can eafily admit. 146. From the red part of the blood, fibres are ge- nerated in abundance ; from the ferum, in fmaller quan- tities. They are procured by pouring the blood into a linen cloth, and wafliing it gradually with a great deal of water, or by beating it with a rod. In quantity, they equal the 28th part of the whole mafs. Thefe are formed of the gluten, and are not generated in a living animal ; feeing they are neither to be perceived by the microfcope, which yet fo eafily renders vifible the red globules, nor yet does their long thread-like figure feera adapted for receiving motion. 147. From the preceding experiments compared to- gether, arifes that knowledge which we, at prefent, have of the blood ; namely, that the craflamentum or cruor is compofed of globules. The inflammable or K 2 ' com- 58 BLOOD. Chap.VI: combuftiblc nature of thefe globules is proved from dried blood, which takes flame and burns ; as alfo from the pyrophorus, which is generated from the human blood ; and from thefe, mod probably, arifcs the greater, part of the pitchy oil that is obtained from blood by the violence of fire. 148. The ferum of the blood, diftilled with a ftrong fire, gives over almod the fame principles with the cru- or, viz. fait, oil, and earth. It yields, however, much more water, but no iron at all. Similar principles, but with a lefs proportion of oil and fait, are obtained from the aqueous humours prepared from the blood; as the faliva, and mucus. 149. The exadf mafs or quantity of blood, contained in the whole body, cannot be certainly computed. The weight of the mafs of humours, however, is much greater than that of the folids ; but many of them do not flow currently in the circulation, as the glue or jel- ly that lodges in mod parts, and the fat. But if we may be allowed to form a judgment from thofe profufe haemorrhages that have been fudained without de- droying the life of the patient, with experiments made on living animals by drawing out all their blood, join- ed with the bulk ot the arteries and veins themfelves : from thefe principles, the mafs of circulating humours will be at lead fifty pounds ; whereof about 28 will be true red blood, current in the arteries and yeins ; of which the arteries contain only one fifth, and the veins the other four. 150. Nor does the blood always contain the fame, or a like proportion, of thofe elements or principles above- mentioned ; for an increafed celerity, whether by labori- ous and drong exercifes, a full age, fever, or other- wife, augments the craflTamentum, with the rednefs, con- gealing force, and cohefion of the particles ; and the hard- nefs and weight of the concreted ferum with the alkaline principles are, by the fame means, increafed. On the other hand, the ferum, and the mucus it contains, are Inpreafed by the contrary caufes, the more as the animal BLOOD. Chap. VI. .^9 is younger, lefs aftive, and fed more on a watery ve- getable diet ; by all which, the craflamentum of the blood is leflened, and its watery part increafed. Old age, again, lelfens the cralfamentum, and the gelatinous part likewife. 1 5 ! . • From thefe principles, but with a conjunft con- fideration of the folid fibres and veifels, the different temperaments of people are derived. For a flsthonc or /anguine habit arifes from an abundance of the red globules ; a phlegmatic temperature, from a redundancy of the watery parts of the blood : a choleric difpofition of the humours feems to arife from a more acrid, acid, and alkalefcent property of the blood ; as appears from thofe who live on fiefh, and on the human fpecies, being fo much fiercer and more palTionate than thofe who live on plants or on vegetable food. In the folid parts, a great firmnefs, joined with an exquifite fenfibility, or nervous irritability, difpofes to a choleric habit ; a lefs irritability, with a moderate denfity, to a fanguine ha- bit ; and a lelfer degree both of denfity and irritability are to be referred to a phlegmatic temperament. There is alfo a kind of dull heavy temperament, in which there is the greateft ftrength of body, joined with no great degree of irritability. In the melancholy, again, a weaknefs of the folids is joined with the higheft degree of nervous irritation or fenfibility. But you muft be careful not to take thefe temperaments as the foie and limited fyftems or clalfes of conftitutions ; which, in the courfe of nature, are found to be not only four, or eight, but are really diftindl in numberlefs degrees. 152. The red part of the blood feems chiefly of ufc to generate heat, fince its quantity is always in pro- portion to the heat of the blood. This being confined, by the largenefs of the globules, within the red and firft order of veffels, hinders them from collapfing ; and, in receiving the common motion of the heart, by the greater denfity of its parts, it has a greater impetus, and fets in motion the leffer ordeYs of humours. Nor is it improbable, that the heart is more flrongly irritated by 7* BLOOD. Chap. VI, the ponderous cruor of the blood. The globular figure of its parts, together with their denfity, makes it eafily pervade the vefiels ; and the quantity of iron it con- tains, as well as of oil, perhaps increafes its power of generating heat. And hence it is, that the red part of the blood being too much diminilhed by profufe bleed- ings, there follows a ftagnation or leffened motion of the humours in the fmaller vefiels j whence fatnefs, and dropfy. By the fame rule alfo, a due proportion of cruor is necefiary within the habit, to generate and re- pair new blood. For, by large haemorrhages, w'e fee the blood lofes its red or denfe nature, and degenerates into a pale, ferous, or watery fiate. I5g. The coagulable ferum is more efpecially de- figned for the nutrition of the parts, as will be hereafter more apparent. Chap. XXXI. The thinner juices ferve various purpofes; as the difiblution of the aliments, the inoiftening of the external furface of the body, and fur- faces of the internal cavities, to preferve the flexibility of the folids, and conduce to the motion of the nerves, the fight, &c. The laliiie particles feem proper tor dif- folving the'aliment, and ftimulating the vefiels. The properties of the aerial part are not yet well known. The heat produces fluidity, and is not eafily raifed to fuch a degree as to coagulate the humours. 1 54. Therefore, health cannot fubfifl: without a denfe and red blood, whofe quantity too much diminithed caufes a ftagnation of the juices within the fmaller vef- fels ; whence all parts of the body become cold and weak. Nor can life or health fubfift w'ithout a fufiiciency of thinner juices intermixed with the red blood ; fee- ing the cruor, deprived of its watery part, congeals and obftrucls the finalleft paffages of the veffels, and kindles too great a heat. 155. If it is afked, whether there be any difference betwixt the arterial and venous blood ? we anfwer, that fome difference there feems to be ; the former having lately fuffered the action of the lungs. But, in experi- rqents, I fcarce find any obfervable difference either in colour. Ch’Ap. VII. ARTERIES. 71 colour, denfity, or any other known diverfity. Other- wife, however, I have found a moft evident difference ; for the bright red colour of the arterial blood feems to diflinguifh it from the dufky dark-coloured blood in the veins ; but this, in the plain example of the hatch- ing of a chicken, arifes only from the deeper feries of globules in the thicker vein. But we have not fuffi- cient certainty of a difference in the blood of different arteries. However, the arterial blood is apparently of a more bright or fplendid red ; and having a greater degree of fluidity and proportion of watery parts, may fo far differ from the venous darker-coloured blood. But, in this refpe^:, it remains that we make further experi- ments. 156. From one and the fame mafs of blood, driven into the aorta, are generated all the fluids of the human body ; which, from their affinity one to another, are reducible to certain claffes. The manner by which they are feparated, ought to be accounted for by the fabric or mechanifm of the glands themfelves. But we mufl firft confider what the blood fuffers from its containing veffels. CHAP. VII. Of the Common Offices of the Arteries. 157. ^ I ’’HE blood is driven from the left ventricle of A the heart into the aOrta ; which takes its courie firft a little towards the right, and then to the left, in an arch that is very fharply bent : and here the mafs of this purple fluid ftrikes firft againft the right fide, and is then reflefled to the left fide again of the aorta ; whence, flowing in a vortical or whirling motion, as mach as that full veffel will permit, it goes on through the arteries, with an alternate collifion againft, and re- percuffion from, their fides. The aorta fwells a little in bulk at the place where it proceeds from the heart. 158. The 72 ARTERIES. Chap. VIE 158. The arteries are, in a living perfon, always full of blood ; fince the jet or ftream that harts from an ar- tery, is not interrupted by alternate hops, while the heart rehs or relaxes itfelf, but it hows on in a continu- ed thread : add to this, that the microfcope fhews the arteries, in living animals, to be full, both in their fyhole and diahole ; nor can the circular fibres of the arteries fo far contradl thernleives, as entirely to evacuate thefe tubes. Since, therefore, a new wave or column of blood is fent into the arteries, already full, although it bear a fmall proportion to the whole mafs contained in the arterial fyhem throughout the body, hardly ever exceeding two ounces ; yet, by its immediate contact •with the precedent wave or column, which moves hower as it gets farther from the heart, it confcquently drives the fame forwards, lengthens the artery, and makes it af- fume a cylindric form, augments its diameter, preffes the membranes clofer to one another, urges the convex parts of the arterial flexures outwards, and caufes their fpiral waves to be more ferpentine, as injections demonftrate to us. This dilatation of the artery, w'hereby its light or capacity is changed from a lefs to a greater circle, is called the pulfe ; the diajlole of which, is an expanfion of the artery beyond its natural diameter. This being the proper or charaCteriftic aCtion of life, refults from the heart only, and is in nowife natural to the arteries left to themfelves. Hence, w'hen the motion- of the heart is intercepted, whether by aneurifm, ligature, or otherwife, there is no pulfation of the arteries to be felt ; and from hence, too, there is a fudden ceflTation of the pulfe, by a wound through the heart, in a living animal. But the artery is proportionally more dilated, as the wave of blood flows on before more flowly, and the more the velocity of the new wave exceeds that of the former one. 1 5 9 . The fyjlole or contraction of the artery follows the dilatation of it. For the heart, having emptied itfelf, and removed the ftimulus of the blood, comes into a ftate ®f relaxation and reft. But the artery, at this fame time. Chap. VII. ARTERIES. 73 time, by its innate elafticity, and contraftlle power re- ading in its circular fibres, irritated likewife by the fti- mulus of the blood, contracts itfelf, and expels as much blood as ferved to dilate it beyond its mean or middle diameter : this quantity of blood is either for- ced into the fmalier and fcarce-beating arteriolae, or elfe returned into the veins, from the refiiting femiiunar valves of the aorta, which oppofe the reaction of the blood from the neighbouring parts of that veffel. So foon as the artery has freed itfelf from this wave or co- lumn of blood, being no longer ftimulated by dillen- tion, it directly collapfes by its own proper contractile force, and is now again ready to yield to a new wave or column of blood, fent into it from the heart ; whence follows a repeated diaftole. 160- That the arteries thus contraft, and, by that force, drive forward their contained blood, is proved evidently from their ftrongly-ContraCtile nature; front the apparent diminution of the diameter or dilatation they receive from the heart ; from the evacuation that follows, by the proper force of the artery itfelf, driving' out all the blood that is contained in the lateral branches, betwixt two ligatures ; from the return of the blood to the heart through veins whofe artery is tied, and fo can- not propel the blood to the heart ; from the jet of blood being greateft when the heart is in its diaftole, as ob- ferved by fome eminent anatomifts ; from the firength with which the blood is thrown out of the tied aorta, below the ligature ; from the evacuation which the ar- teries make of their contained blood, even after death, into the veins, whereby thefe latter appear much fuller than the arteries ; and, lafily, from the confiderable jetf or faltus of blood, that iffues from a large artery in an animal, even after death, mounting to the height of two feet : to which add, the convulfive contraftions of the animal in which the artery is thus wounded, and the remarkable clofings of the mouths of divided arte- ries in wounds, and a fphacelation of the limbs from L an 74 A R T E R t E S. Chap. VII. an offification of the artery ; whence the veins become diftended. 161. The mean fwiftnefs of the blood’s motion be- ing diminifhed in the time of the heart’s fyflole, but in- creafed during its diaftole, is fuch as carries it through a fpace fomewhat lefs than one foot in the fpace of a fecond of time ; and the conflant plenitude of the ar- teries renders it impoffible for us to perceive any fuc- ceflion in the pulfes of different arteries ; whence all the arteries of the body feem to beat at one and the fame inftant, whiKt the heart ftrikes againd the bread : and yet there is certainly a fucceffion in the fydole of the arteries, by which the aorta feems to contract in the fame order fucceffively, as it is filled by the blood ex- pelled from the heart ; fo that the pait of the artery next the heart is fird condringed, and thence, gradu- ally, the arterial contrafting force proceeds to the ex- tremities. An indance of this we have in the intef- tines; and the fame is evident to the eye in iufeds, who have a long fidulous and knotted heart, maniftlUy con- trafting in a fucceffion from the beginning to the end. But the mind cannot didinguiflr the lead points of time, which are the mea.^ures of this fucceffion, and amount only to a few thirds of a fecond. 162. If it be afked. Where this pulfation ends: we anfvver, In the lead arteries, and cylindrical origi- nations of the veins. We have already mentioned the velocity with which the blood comes from the heart. But that velocity continually decreafes. Certain we are, ( i .)That the lights or feftions of the arteries, com- pofed by the aggregation or fum of their tranfverfe fec- tions, as they divide farther, in their ccurfe, from the heart, greatly exceed that of the aorta ; fo that fince the ratio, or lefs proportion of the trunks to their branches, continually diminiflies as they make lefs ra- mifications, and this in a variable or uncertain pro- portion ; the difference of that ratio or proportion will be the greated betwixt the light of the aorta at the heart, and the fum of the fe6;ions of all the fmall ar- teries. Chap.' VII. ARTERIES. 75 teries, where they are leaft, in the extreme parts of the body. Again, (2.) The proportion of the arterial membranes or coats in thicknefs, with refpedl to their bores or capacities, is greater as the arteries grow lefs ; and is larged: in the lead: of them, which tranf- mit only one globule at a time. The truth of this is proved from anatomy, and the forcing of air into the arteries, by which they burd: always more difficultly as they are lefs ; and from the calculation itfelf, by which the magnitude of the lead: arteries is determined from the globules difiending their two femicylindric mem- branes'. Add to this, (3.) The friction of the juices through the lead: vedels, infected and meeting toge- ther in angles ; which fridtion, even in the molt duid water, running through long pipes that are fingle, and in a direct courfe, greatly diminidies the velocity, and more in proportion as the tube is of a lefs bore ; while again, as the artery is lefs, there are a great number of globules rubbing and grating againd: its membra- nous converging fades. And by the conical figure of the artery, it happens, that the broader wave of blood coming from the trunk is rdifled in its paffage through the narrower branch, and fo mud: diflend it by force. But moreover, (^j.) The inflections and folds, or plates, of the veffels, greatly^ dacken the blood’s motion j fince always fome part of the impelling force is fpent and loft in removing the convex parts of the folds, and changing the figure of the indedled vedel. The angles likewife take off more from this force in propor- tion to their acutenefs, or the more they recede from a ftraight line. I.,ad]y, (5.) The great vifcidity or tenaci- ty of the blood itfelf mud: be confiderably allowed for j fince, by reft only, it direiStly hardens into clots ; and fince it is from the circulatory motion only of the blood, that this mutual attraction of cohefion in its parts is over- come, fo as to hinder it from adhering together, or to the fades of the arteries ; for fo we find it adhere in aneurifms and wounds of the arteries, or elfe the glo- bules clot together, as we fee ufually after death. L 2 Erpm 76 ARTERIES. Chap. VII. From all which coiifiderations, you will obferve, that the blood meets with the greateft retardation, in its courfe, in the leaft velTels. And the oppofition it meets with in the branches leffens the velocity of the blood alfo in the trunk : the oppofition of torrents of blood to one another in the anaflomofes of veffels alfo de- flroys fome part of its motion. We may eafily per- ceive the amounts of this retardation will be very con- fiderable, although it be difficult to make a juli efli- inate of it. In the larger trunks, the blood of a living animal flows with the rapidity of a torrent : but, in the leaft branches, it creeps along very flowly ; fo that, in thefe, it begins to put on a ftate of coagulation. It is alfo well known to furgeons, that a fmall branch of an artery near the heart or aorta bleeds more dan- geroufly than a much larger one that lies at a greater diftance. The weight of the incumbent atmcfphere, of the mufcles and flefliy parts lying above the artery, and the contractile power of the veflel irftlf, make a refiftance indeed to the heart, but do not leflTen the ve- locity of the blood, feeing they give as much in the dia- flole as they take away in the fyftole. 163. It is certain, however, from incifions made in living animals, that the Angle globules of blood, which move feparately in the fmall veffels, do not lofe fo much of their velocity as, by calculation, they ought to do. We muft therefore give fome other caufes by which this deftruCtive power of the blood’s motion is leffened. And, in the firfl place, it is certain, that the lights of the branches do not bear fuch a propor- tion to the trunk in the fmallefl veffeh- ; ti;Cir great Imoothnefs diminiflres the friftion. The facility, like- wife, with which the blood flows through the veins, expedites its paffage through the little arteries which immediately communicate with thefe veins. No great effect, indeed, can be expected from the weight of the blood, or the force of the nerves, which are both ca- pable of diminilhing and accelerating the motion we fpeakofj but, in live animals, thefe have very little ftrength. Chap. VII. ARTERIES. 77 ftrength. The power of derivation, whatever that is, and the motion of the mufcles, are capable of pro- ducing a new velocity. 164. The pulfe therefore enfues, becaufe the ante- rior wave or column of blood moves on flower, while the fubfequent or pofterior wave comes fader ; fo that the precedent is an obllacle to the confequent blood (158.) But fince the force of the heart weakens as the blood goes on, and the contraftile power of the arte- ries increafes, therefore the difproportion of celerity, betwixt the antecedent and confequent waves or co- lumns of blood coming from the heart, will be conti- nually lelTening, with refpeft to the blood that is urged on by the contradfion of the fmaller veffels, till, arri- ving at a part where there is no excefs or difference, it will there ceafe to make any pulfation of the artery ; becaufe here the anterior and confequent blood flow evenly, or with the fame celerity. But this place of equality, in motion, cannot be in the larger and more confpicuous arterial branches ; for in them, the wave, laft coming from the heart, moves quicker than what went before ; as is evident from the inflammatory pul- fation of them, efpecially in the fmall arteries of the eye.' But, in the leaft red arteries, the pulfe at length begins to vanilh. This is evident from the equable motion of the blood, often feen by a microfcope, thro’^ the arteries of a frog. In the larger veflels, however, fuch as may be about the fixth part of a line in diameter, the pulfe is perceptible. But in the lead veins vifible to the eye there is no fenfible pulfation or accelerated motion of the blood, whilll the heart contracts, demonflrable either by the microfcope or any other experiment. 165. Even in the veins, the blood preffes againfl; their Tides, as appears from the furrows hollowed out of the bones, and the fwelling of the veins on being tied. If it is afked, why the veins do not beat? (for we do not allow that to be a pulfe which happens from re- fpiration, from the rejeftion of the blood from the right auricle, ^8 ARTERIES. Chap. VII, auricle, or from the mufcular part of the vena cava) ; the reafon of this feems to be, that the blood, when it immediately leaves the heart, is more retarded in its motion, than when it paffes into the fmalleft veffels. Hence, the lliort fpace of time by which the velocity of the laft wave exceeds the foregoing, is greateft at the heart, and grows gradually Id's, till at lafl it totaliv Vanilhes. This is illuftrated by the experiment, in which a pipe, fixed in a leathern tube, and driving forth water in a continual, but llarting dream, does, by a fponge fixed round the mouth of the faid tube, caufethe water to iffue forth in an even dream, without leaping, through the fponge : and the fame is evident from another experiment, in whicli the fame thing happens, by injedting the mefenteric arteries with an alternate impulfion of water ; for then the water flows out through the veins, in one continued even dream. 1 66. The pulje is, therefore, the meafure of the powers which the heart fpends on the blood ; becaufe it is the immediate and full efiedl of thofe powers. Hence, all things confidered as alike, tlie pulfe is in the mod healthy people, where there is no dimuUis, nor any unnatural rcfidance to caufe the effccl; of a di- mulus, but the heart is at liberty to fend forwards the blood wfith eafe. You mud except thofe cafes where there is fome obdacle, by which the blood is prevented from entering the aorta. For this reafon, the pulfe in adhmatic people is flow ; the fame thing alfo happens from a debility or infenfibility of the heart, which the ufual dimulus is not capable of exciting to contradfion. A large pulfe is caufed by fulnefs of the artery, joined v/ith a drong force of the heart ; a fmall pull'e by the emptinefs of the artery, and a leffer wave of blood fent from the heart. A hard pulfe denotes fome obdacle or dimulus ; or elfe, that the heart’s force is increafed with a greater thicknefs of blood, or a greater rigidity of the artery. A quick pulfe denotes fome dimulus, obdacle, or greater fenfibility or irritability of the heart. It is bed felt where the artery lies expofed bare to the touch. Chap. VII. ARTERIES. 79 touch, upon fome refifting bone ; but obflrudions fometimes render the pulfe perceptible, where it is ne- ver fo naturally. 167. The pulfe is flower in animals as they are larger or more bulky; becaufe the heart is prpportion- abiy bigger in the fmaller than in the larger animals, and, as well as the other parts of the body, is more ir- ritable in the former than in the latter ; and becaufe the heart is obliged to drive the blood to a greater di- flance ; whence the refiftances or friclions feem to be increafed, in the more bulky, over the force of the heart. Hence, fmall animals are more voracious ; and large ones, as the whale and elephant, eat lefs. The pulfe of a healthy perfon rifling in the morning, beats 65 in a minute ; but, after the fatigue of the day, it will beat 80 in that time ; and again, by the night’s reft or fleep, it will become gradually lefs frequent, till in the morning you will find it returned to its primi- tive number of 65. For the motions of the mufcles, and actions of the external and internal fenfes, the warmth of the atmofphere, and the action of the ali- ments taken into the ftomach, urge the venal blood on to the heart, which, being thereby oftener flimulated, makes more frequent dontraftions. This is the caufe of thofe paroxyfms or fits of increafe obfervable in all fevers towards the evening. For fleep not only re- tards the motion of the blood, but of all the other hu- mours and actions in the body whatever. 168. A frequent pulfe is different from afwift one; and it is poffible for the pulfe to be at the fame time fwift and unfrequent. But it is difficult to obferve a fwift pulfe. The frequent pulfe is what is commonly called a fwift one. It takes place in children, and be- comes afterwards flower in perfons as they grow older. The falient point beats 1 34 in a minute : new-born in- fants have their pulfe 1 20 in that time; and from thence down to old age it grovvs flower, to 60 in a minute. A feverifli pulfe begins from 96 per minute ; and we count the pulfe has but a moderate celerity in fevers, or labo- rious 8o ARTERIES. Chap. VI!. rious exercifes of adult perfons, if it does not exceed above i lo or 120 in a minute : but it is excelTive at 130 or 140, with which number people feldom reco- ver ; nor have 1 ever obferved it exceed that number. The pulfe beats flower in winter, and quicker in fum- mer, by about 10 ftrokes per minute; and under the torrid zone, it grows quicker to 120. The different pafTions of the mind varioully accelerate, retard, and di- flurb the pulfe. Vv^hatever obltructs the circulation is alfo found to accelerate the pulfe-; not from the laws of hydroftatics, or on account of the canal being mace narrower, nor from the action of the tbul ; only the heart being with more difficulty freed from the ftimu- lating blood, contracts itfelf more flrongly,, and at fhorter intervals. An irritation from an acrid blood is the caufe of the frequent pulfe in fevers. 169. Through the leafl veins the blood moves on very flowly, partly by force of the heart, and partly by the contractile force of the arteries. The firfl is proved by a renewal of the motion of the blood, in per- fons drowned ; where, merely by exciting the adtion of the heart, the whole mafs is driven forwards. But the contractile force of the artery is proved by what is faid (160.) But, after death, the blood continues to move, in part, alfo by its own gravitv, and by the elaflicitv of the air generated or extricated by putrefadtion. 170. But the blood moves on falter in the larger veins. For whenever the impelling powers remain fuf- ficient, and the conveying finall vefl'els are rendered narrower, the motion of their contained fluids mufl: of courfe be accelerated ; fmce the fection of the venal trunk is much lefs than that of ail its branches, in the fame manner as that of an artery is lefs than the fum of the branches into which it divides. Therefore, if the motion of the venal blood lofes nothing in its way, the proportion of its celerity in the vena cava, to its cele- rity in the veins of the thirtieth divifion, will be thirty times greater in the former, in proportion as the con- jundl lights of all the fmall veins exceed the light of the cava. 8r Chap. VII. ARTERIES. cava. In like manner too, the friftion or attrition of the blood in the veins, and its contaft with their fides, diminifli. 171. But fince the blood moves thus flowly in the lead arterial veflels and incipient veins, and as the weight of the blood, itfclf, in many places, wonderfully hinders its return to the heart, while, at the fame time, the very thin coats of the veins have but little contraftile power to be expected from them ; therefore, nature has ufed various precautions, left, from the llownefs of its mo- tion, it Ihould any where ftagnate or concrete. To obviate this, ftie has fupplied the veins with more watery vapours and fluxile lymph than Ihe probably fent by the arteries, if we confider the great exhalation that is made from the arterial blood in the lungs. 172. She has, therefore, likewife placed the veins near the mufcles, that, by the turgefcence or contrac- tions of the latter, the veins may be preffed ; and fince any preffure upon the veins muft be determined to- wards the heart (<53.), therefore all this force muft be en- tirely employed in accelerating the return of the blood to the heart. From hence proceeds that wonderful quicknefs of the pulfe (167.), heat, and rednefs of the body, with a fhort and laborious breathing, that attend mufcular motions or violent exercifes. 173. Moreover, thofe mufcles, which coiiftantly urge or prefs violently the contiguous vifeera on all fides, that are contained in any of the common cavities, do all of them powerfully promote the return of the venal blood to the heart. Such an effeft has the conjqnd: preffure of the diaphragm with the abdominal mufcles, in refped to the abdomen. Laftly, the pulfations of the arteries, which run every where contiguous and pa- rallel by the lides of the veins, have no inconfiderable effect in promoting the return of the venal blood j fince, as we have before fliewn, any impulfe adling on the veins can determine their blood to the heart only. 174. To thefe is added a force not yet fufficiently known, by which the blood is brought from a place M where 82 ARTERIES. Chap. VII. where it is more compreffed to one more lax, and where it meets with lefs refiftance. In this matter alfo refpiration is of great efficacy; in which the motion of the blood into the lungs when relaxed is accelerated by the power of derivation from all parts of the body: and again, in exfpiration, it is driven into the trunks of the veins in the head and abdomen. Hence the fwelling _of the veins, and likewife of the brain, in the time of exfpiration. The circulation is not indeed affifled by thefe caufes, but the blood is agitated and prefled. The anaftomofes of the arteries contribute to the fame end ; for they render the paflage of the blood more eafy from thofe places where it is obflruded, to fuch as are more free. 175. By thefe means, the blood in a healthy perfon, uflng fufficient exercife of body, moves on with fuch a velocity, as fuffices to deliver as much of the purple fluid in every pulfe by the vena cava to the heart, as is equal to what is fent out by that great artery the aorta. But reft or inaftivity of body, and a weaknefs of the contracting fibres of the heart and other mufcles, fre- quently render this motion of the venal blood more dif- ficult. Hence follow varices and the piles in women with child ; which latter is much occafioned from the deficiency of valves in the vena porta. And from hence fpring even the menfes themfelves. And when the veins too flowly return their blood to the heart, the fubtle vapours from the lead veflels irrigating the parts^ being thus refilled, or fcarce able to return to the heart, are obliged to ftagnate; whence proceeds that frequen- cy of cedematous and pitting fwellings of weak people, 176. The time in which an ounce of blood, fent out from the left ventricle of the heart, returns to the right, and which is commonly reckoned the time in which the greater circulation is performed, is uncertain, and dif- ferent in every different portion of the body. If, how- ever, you want to know about the ounce of blood pro- pelled in that quantity which we have mentioned, the amount of it will be about 7^ ounces in an hour, with 4500 Chap. VII. ARTERIES. 83 4500 pulfes; and the amount of the perfect circulations will be about 2 j,-. 177. The elFcdis which follow from the motion of the heart and arteries upon the blood are various, which may be deduced and eftimated from the caufes them- felvcs of thofe effects, if we compare together the blood of a living and of a dead animal, that which is healthy with that which is difeafedj and that which is inert or too little moved, with that which circulates too fwiftly. For we obferve, that, in the living, the blood is, (1 .) Con- fiderably warm or hot. (2.) It looks red, with a fort of purple florid hue. (3.) It feems to be homogene- ous or uniform, and alike in its parts ; though they are really mixed, and pf different principles. (4.) It is made up almoft entirely of globules. (5 .) It flows very readily through the leafl; velfels ; from whence being drawn, ,(6.) It exhales a volatile vapour, which we have already defcribed particularly. In the dead ani- mal, which has not yet begun to corrupt or putrefy, we obferve, ( \ .) That it has loft a great deal of its rednefs. (2.) That it feparates into a more denfe and a more thin fubftance. (3.) That it exhales no vapour. (4.) Be- ing drawn out from the veins, it congeals either all or the greateft part. But even in the living animal, when very weak, where there is fome pulfe or refpiration, though fmall, we find the blood cold, even to a confi- derable degree. If, again, you compare the blood of a human perfon unaftive both in body and mind, with the blood of one that is addicted to violent exercife, you will obferve the latter has, ( i .) A greater heat. (2.) A more intenfe rednefs. (3.) A fubftance more compact, and fpecifically heavier. And, (4.) The vo- latile parts more abundant. All which appearances feem manifeftly the effects of the motion of the heart and arteries, fmce they proportionably increafe and di- minifli with that motion, and difappear when that ceafes. 178. That we may underftand the manner in which thefe appearances are produced in the blood, we muft confider what are the effeds of the heart impelling the M 2 fame, 84 ARTERIES. Chap. VII. fame, aad of the arteries alternately comprefling and urging it forward. And firh we fee, that the heart drives the blood into the arteries with a very great ce- lerity (123.) With a confufed or vortical motion, the heart thus throws the blood into the crooked or inflec- ted arteries, in fuch a manner, that the right globules, expelled through the opening of the aorta, ftrike againft the left fide of the artery ; from whence being repelled, they incline towards the right fide, whereby all the par- ticles of the blood are agitated with a confufed or tur- bulent and whirling motion. The blood thus impelled againft the flexile and curved fides of the arteries, of neceffity dilates or diftends them into a greater con- vexity ; and laftly, in the fmaller veflels, capable of re- ceiving only one or a few of the blood-globules, all the faid globules come fo intimately into contadl with, and grate againft, the fides of the faid artery in all their points, that they are even obliged to change their fi- gure in gaining a paflTage into the veins. 179. But the arteries, by their elaftic force, reacting upon the impinging blood, repel the fame from their fides towards the axis of their light or capacity ; and, at laft, tranfmit every fingle particle of it through the circular mouths of the leaft veflels, by which the arte- ries and veins join together. 180. There is, therefore, a moft prodigious degree of friftion, as well of the blood-globules againft the. fides of the arteries, as of the arteries themfelves, con- trading round the blood like an obftacle ; to which add, the attrition of the particles of the blood amongft each other by the confufed and vortical motion with which they are propelled. The efFefts of this friction may be computed from the vifcid and inflammable nature of the blood itfelf, from rhe narrownefs of the veffels thro’ w'hich it runs, and from the ftrong impulfion of the heart, joined with the powerful reaction of the arteries; to which add, the weight of the incumbent parts raifed by the force of the arterial blood. This fridion gene- rates a fluidity in the blood, by perpetually removing Chap. VII. ARTERIES. 85 the points of contaft in its globules, refilling their at- traction of cohefion, mixing together particles of dif- ferent kinds, which become more fluid upon mixture, as we have an inftance in oil when triturated with wa- ter. It alfo augments the fphericity of the particles, by breaking off their protuberances and little branchings. But even thefe very fmall particles themfelves, which are broken off from the large particles of the blood, put on a round figure by their friClion againft the fides of the canals, and their rotatory motion among the reft. By deficiency herein, the blood coagulates in the velfels before death ; and from hence, the lofl flui- dity of the blood is again reftored, by recovering the motion of the heart, as we are taught' by experiments made on living animals. It is a queflion w^hether this motion of the blood, and the denfity proceeding from it, is the catife of the red colour of the«blood, feeing the rednefs is in proportion to the denfity, and increafes or decreafes from the fame caufes. This feems.to arife from a mixture of the ferruginous with the oily part of the blood. 1 8 1 . We may alfo afk, whether the heat of the blood does not alfo proceed from its motion ; feeing we ob- ferve heat to arife from the motion of all kinds of fluids, even of air itfelf, in our experiments ; but much more does this attrition produce heat in the elaflic and com- buftible animal juices, which are denfer than water, and compreiTed with a confiderable force by contraClile and converging tubes. Is not the truth of this fuf- ficiently evidenced, by the blood’s being warm in thofe fifli which have a large heart, and cold in fuch as have a fmall one? the generation of heat being in propor- tion to the fize of their bodies : from the more in- tenfe heat of birds that have a larger heart, and more frequent or quick pulfations ? from the increafe of a- nimal heat, that enfues from exercife of all kinds, and even from bare fridlion of the parts ? from the congelation of all the humours of the human body in a certain degree of cold, in which a man grows ftilF, though 86 ARTERIES. Chap. VIL though he yet retains fome warm blood and is alive ? and from the coldnefs of fuch people as have their pulfe weak and obfcure? Nor does the heat at all arife at firfl; from any degree of putrefadlion in the blood, feeing the humours themfelves, when left at reft, generate no heat. Nor muft we explain an evident appearance from the adlion of fuch an obfcure being as the vital ■power; and though fometimes the heat may be greater when the pulfe is flow, and lefs when it is more fre- quent, the difference may arife from the different dif- pofition of the blood, from the different denfities of the veffels, or the increafc or diminution of perfpiration. 182. The fame caufe alfo hinders putrefadion, by not fuffering the inteftine motion to be diminifhed, and by diffipating fuch particles as have already begun to be corrupted. 183. But the different natures of the feveral parti- cles themfelves, which conjunftly make up the mafs of blood, are the caufes whereby, from one and the fame impetus of the heart, different effects or confequences are produced indifferent particles of the blood. Name- ly, thofe particles move quicker, whofe greater den- fity makes them receive a greater impetus, and whofe apt figure or lefs extended furface makes them meet with lefs refiftance in the fluid in which they move. Thofe alfo are driven along more fwiftly, which, either from their weight, or from the direction in which they pafs out from the heart, are urged chiefly into the axis of the veffel. Thofe again will ftrike againft the con- vexities of the flexures in the arteries, which have the greateft projefHle motion ; while the other parts of greater bulk and tenacity, having lefs projectile mo- tion, will move fluggiflily along the concavity of the veffel. And in this manner is the blood prepared or difpofed for the feveral fecretions. 1 84. 'I'ht fyflole of the arteries renders the parts of their contained fluids more denfe or compact, while they contract round the blood as round a folid ob- ftacle, which being in fome parts vifeid and compref- fible Chap. VII. ARTERIES. 87 fible, they drive and expel the mere liquid parts into the lateral mouths or du£ls, at the fame time increafmg the points of contatl betwixt the globules themfelves, uniting together their more large and denfe fpherules, and compading the flat particles into denfer bodies. But the denfity of the blood is partly as the number of globules, and partly as the denfity of the materials whereof thefe globules are compofed. 1 85 . Moreover, the mouths of the leafl; veflels, per- vious to only one globule at a time, feem to be a fort of moulds to figure and break off the angular eminences of the particles in the blood, and bring them to a fphe- rical figure ; which at length they put on, and change into perfed fpherules. Laftly, from hence arifes the denfity of thofe particles ; fince, of all figures, fpheres contain the moll within a given furface. 186. The reticular diftributions and inofculations of arteries remove any danger of obllrudion ; fince in any part of the artery, where the blood cohering begins to form an obftrudion, a contrary flux is admitted, where- by the obftructing matter is repelled to a larger part of the trunk, and thus betwixt the reflux and the dired torrent of the blood the faid matter is broke and atte- nuated. This mechanifm alfo fupplies the deficiency from an irremoveable obftrudion or the lofs of a veffel, by caufing a greater diftenfion or enlargement of the next adjoining or anaftomofing veflel ; as is proved by experience in furgery, after tying and cutting a great artery. The collifion of thefe oppofite torrents of blood take fomething from its velocity; and the reticular di- ftribution augments the fridion of the globules. 187. As the quicker motions of the blood in the trunks conduce to fanguification, fo the flower motions of it, in the leafl; veflfels, have their effeds towards the fecretions. In the larger arteries, we fee the different particles of the blood are whirled about amongfl each other, with a rapid and confufed motion ; but, in the leflfer ramifications, the progreflive motion of the blood being diininifhed, the more loofe colourlefs particles depart 88 ARTERIES. Chap. VIII. depart laterally from the more denfe and red globules, while the latter, keeping on their courfe more firmly along the axis of the veil’d, expel the former laterally and to the circumference. Thus the attradive powers of the particles in the blood increafe, as their progref- five motion abates hence, the oily or fat particles are drawn one to another, and go off by the open lateral du£ts which lead to the cellular fubltance, which par- ticles we know are both grofs and lluggilh : and again, other thinner juices are fent olF through lateral branches of a much fmaller orifice, till at length little more than the red blood alone remains to pafs through the eva- nefcent artery into the incipient vein. But all thefc particulars, whereby the blood is difpofed for the fe- cretions, we fliall confider diflinctly in the following chapter. CHAP. VIII. Of the Secretions. 188. B ’♦HE claffes or tribes of humours which, bc- _L ing depofited or {trained off from the blood into other vdl'els, are faid to be fecerned or fecreted, feem reducible to four: of which the frft includes all the vifcid and lymphatic juices, which are coagulated by a heat of about 150 degrees, by alcohol, and by a- cids; although generally, in the living animal, they are capable of flying off in form of a vapour, and after death are within the fame veffels compacted into a ge- latinous thicknefs. To this clafs belong the vaporous juices of the ventricles of the brain, of the pericar- dium, pleura, peritoneum, vaginal tunic of the teflicle, of the amnios, joints, and probably of the womb, with the juice of the ftomach and inteflines, of the renal capfules, and laflly the lymph itfelf commonly known and called by that name. i8p. The fecond clafs is of thofe juices, of which feme Chap. VIII. SECRETIONS. gp fome are exhalable, like the former (i8o.), but, be- ing more fimple and aqueous, are neither to be coa- gulated by fire nor by redificd fpirits of wine; and others do not exhale, but, being depofited in their rel'pedive excretory duds, are expelled by fome com- mon outlet, proper to a part of fome gland. To the former of this clafs belong the perfpirable matter of Sandorius, and probably the internal perfpirable mat- ter of the epithelium and cellular fnbftance, with part of the tears and watery humours of the eyes. To the latter of this clafs belong the remaining part of the tears, the faliva and pancreatic juice, that of the renal capfules, and the urine. The fweat feems to be a mix- ture of the perfpirable matter and the fubcutaneous oil. 190. The third clafs, differing from both the prece- ding, includes the vifeid, fluggifh, or ropy juices; but fuch as are of a watery difpofition, and not congealable into a jelly, but hardening into a cruft-like or fcaly fubftance, by exhaling their water. Thefe do not ef- fervefee with any fait, and are contraded and made thicker by acids. By lixivial falts they are diffolved. By fire they are refolved into water, a little volatile fait, and a little oil. Of this fort are all the kinds of mucus in the human body, fpread through all the inter- nal paffages for air, aliments, or urine, and the cavities of the genital parts, liquor of the proftates, and feed. 191. The fourth and lafl clafs is that of the inflam- mable juices, which, at their firft formation, are indeed thin and watery, but, by time, ftagnating and exhaling their more watery parts, become a thick, oily, inflam- mable liniment, often very bitter. To this clafs we re- fer the bile, ear-wax, febaceous and oily liniment of the fkin, the marrow in the bones, and all the fat of whatever confiftence or in whatever part feated through- out the human body. To this clafs alfo belong caftor and the yolk of an egg. And the milk itfelf, fo far as it is butyraceous and inflammable, belongs to this clafs. 192. Other humours, which we have deferibed as N Ample, SECRETIONS. Chap. VIII. fimple, arc compounded of the foregoing ones ; as milk is compofed of butter and water, and the lini- ment of the joints of lymph and fat. 193. Thofe who confider, that in the blood arc found a coagulating ferum (i 37.), an exhaling water a fort of vifcid mucus (138.), and laftly an oil (142.), may thence begin to perceive the poffibility of a feparation to be made from the blood of all the foregoing clafles (188. to 191.) of humours; in as much as we thus fee their conftituent principles are al- ready in the mafs of blood itfelf. But in what manner it is brought about, that oil is feparated from the blood in one part, a watery liquor in another, or a gummy mu- cus in a third, is a talk that Hill remains to be explain- ed, and requires a previous defcription of the fccre- tory organs themfelves. 194. The coagulable juices are feparated almoft every where, from the arteries themfelves, into conti- nuous excretory canals, without any intermediate or- gan or machine betwixt them. The proof of this we have from injedlions of filh-glue, water, and thin oils, which very readily pafs the red arteries, and are pour- ed out like unto fweat into all the cavities of the body in which that coagulable vapour is naturally found ; nor do the injedlions in this courfe meet wdth any interme- diate knots or flops from any hollow cavities or cells. Finally, the blood itfelf, being fo readily poured out into moll of thefe cavities, without any permanent da- fnage, when its courfe is either much obftrucled, re- tarded, or urged with a greater impetus through the arteries, fhows plainly that there is a fhort and open way betwixt the red blood-veffels and thofe excretory dufts, 195. Another liquid, coagulable by acid fpirits and alcohol, is the albuminous humour of the joints. This being compofed of fat, medullary oil, and the exha- ling liquor, conflitutes an exceeding foft liniment, very fit for lubricating the cartilages, and leffening the fric- tion. For fecreting this, there arc appointed certain conglo- Chap. VIII. SECRETIONS. pi conglomerate glands of a peculiar ftrufturc, which arc fituated in the articulations of the bones, fo that they may be moderately comprelTed, but cannot be crufbed. 196. The ftrufture of thefe glands is peculiar to themfelves. The larger clufters of glandular kernels adhere, for the moft part, to the bone by a broad balls wrapped up in fat. From thence, being drawn out into a kind of crefted edge, they pour out their liquor from an exceedingly thin border, by open dudts, which however I do not find very evident. Other lelfer ones, placed every where in the capfules of the tendons, and between the diverging fibres of the ligamentary cap- fules of the joints, feem to be much of the nature of fimple glands, and are turgid with yellow mucous ferum. 197. The uncoagulable juices (1 89.) of the firft fort are fecreted in the fame manner with thofe which hard- en (188.); to wit, from the exhaling arteries, which arife from the red fanguineous arteries, without any intermediate follicle or cavity betwixt them. Thus the veffels, which pour out the perfpirable matter through the (kin and lachrymal dufts of the firft fort, fuffer a watery or thin gluey injeflion to tranfude fo readily from the arteries, as leaves no room to doubt of this truth. And thefe fecretory dudfs have alfo a confider- able degree of irritability ; whence, by any ftimulus or contadl of acrid particles, they difeharge more juice in a given time, than what they diftil in a ftate of health. 198. But in the latter falival kind of that clafs, the fecretion is made by means of conglomerate glandules, which the ancients fo called from their clufter-like fa- bric, and efteemed them ahnoft the only proper glands. Thefe are compofed of roundilh lobules or clufters (fomewhat like thofe in bunches of grapes, currants, barberries, &c.) loofely conjoined together into larger maffes by the yielding cellular fubftance, which, at laft, often forms a denfer coat or covering to the whole, like as we fee in the parotid and maxillary glandules. Through the intervals, betwixt thefe glandular clufters N 2 9^ SECRETIONS. Chap. VIII. or grape-like bunches, run the arteries and veins, which are here large or confiderable enough. But moll of the conglomerate glandules feparate their juices in fuch a manner from the blood, and from thence dif- charge it fo, that each kernel fends out an excretory du(St, which, joining v/ith others of the fame kind, form larger trunks, which at laft, in the manner of a vein, end in one canal, which conveys the humour, feparated by the gland, to the part for which it is de- figned, as the cavity of the mouth, inteftines, furface of the eyes, &c. There are, indeed, fome of thefe glands in which the faid excretory ducts are either not prefent, or at lead not yet difeovered ; as we obferve in the thyreoideal glandules, thofe called capfuliz renales^ and the thymus, unlefs we fuppofe thefe to approach to the nature of conglobate glands. 199. The acim or kernels of thefe conglomerate glands are each of them circumferibed and limited by a harder ftratum of the cellular fubftance ; by which fubftance they are alfo fubdivided into leffer acinuli, as is evident to the eye and by the microfeope. But it may be queftioned. How does this fubdivifion end ? Whether or no is every hmple acinus or kernel hollow in its middle, that, by receiving the humour tran- fuding from the arteries into the follicle or cell, it may be fent out thence by the excretory du£l ? Whether or no are we perfuaded to believe fuch a fabric obtains from the fmall fliot-hke Hones and hydatides bred in thefe glands, with the round feirri that fometimes fill the kidneys ? Whether are the larger vifeera, appointed for fecretion, of the nature of conglomerated glands? Whether is this opinion made probable from the morbid round concretions formed in the liver, fpleen, kidneys, tefticles, and cortex of the brain ; or from the bunch- like divifion or appearance which thofe vilcera have in younger animals ? Whether the cellular fubftance, that furrounds the extreme vafcules in all parts, does not communicate by open areolae or cells, in which a fecreted humour is poured by thefe glandules? 2CO. In Chap. VIII. SECRETIONS. 93 200. In fliort, none of thefe arguments appear true or conclufive. For the acini, which are found in the vifeera of brute animals, are component lobules, and not elementary parts ; but are large and compounded, for the conveniency of each beaft. The morbid con- cretions are almofl: all of them a fort of placentulsc formed in the loculi of the cellular fubftance, and take up their fear even in the limbs themfelves, where there is not the leafl room to fufpeft any thing of a glandular fabric ; and are compofed, as to their matter, of oil, earth, and vaporous particles, extravafated into fomc of the lead interftices of the cellular fubftance, where, ftagnating and comprefling the adjacent follicles, they form to themfelves proper membranous tunics. On the contrary, the watery and fluid nature of the juice fecreted in thefe glands (189.) is an argument that it meets with no arreftment in the feparation, nor places of ftagnation in its way. For all the juices that reft any time in the warm cavities of the human bo- dy, which are full of abforbing veffels, are each of them more or lefs infpiffated, and approach either to- wards a mucous or an oily difpofition. Moreover, if there were any fuch arreftments, anatomical inje6;ions would meet with more difficulty in paffing from the ar- teries into the excretory dutls of thofe glands ; which, under fuch ciicumftances, would be impervious to thick injecHons, and thin ones they would exhale into their cellular fabric. Yet we fee that the fuperlative art of great anatomifts has not only conveyed injections, but even thick ones like wax, direCtly from the arteries of the falival glands, liver, &c. into their excretory duCts ; and this without filling up any intermediat<^ knot-like cavities, which, according to the foregoing hypothefis -(199.), they ought to exhibit. 201. Therefore the acini or kernels of thefe glan- dules appear compofed merely of arteries and veins di- vided and fubdivided, parted and connected by the in- tervention of a good deal of cellular fubftance, whofe ftrata growing gradually more compaCt or firm as they enlarge 94 SECRETIONS. Chap. VRI. enlarge, at length fhow their contents moulded into a fort of globular nut-like figure. In the belief of this, we are confirmed by analogy in the lobes of the lungs, the lobules of the thymus, and from the ftrufture of infects; but more efpecially the fabric of the tefticle, in which we plainly fee, that the lobules are formed of excretory dufts, connected together in fafciculi by a very foft membrane. But they feem not to pour their juices into a cellular fabric, which would intercept or make difficult the paffage to an excretory du£t. The late experiments alfo of very eminent anatomifts have fhown very fmall, white, cylindric vcflels, to be the real elements of the vifeera; and it is to be hoped that this difeovery will be confirmed by future obfervations. 202. Thin watery juices, neither coagulable nor wholly evaporating, are likewife in other parts genera- ted without the ailiftance of conglomerate or kemelly glandules. For thus the urine is depofited from the red or fanguineous arteries into membranous pipes, with which they are manifeftly continuous, and form an cafy way, admitting air, water, and mercury, to pafs in like manner. And after the fame manner, though lefs evidently, the nervous juice feems to be feparated in the brain. 203. The third clafs, or mucous juices (190.) are in- deed almoft every where feparated into, and difeharged from, finufes or hollow glands. Thefe true glands or follicles have, in general, fuch a fabric as makes up an ample cavity, every where circumferibed by a mem- brane ; but in fuch a manner, that the fleffi itfelf of the part, to which the gland adheres, is often taken for another clofe hemifphere of the follicle. The faid ca- vity or follicle is for the generality round : but fome- times it is oblong, and obliquely creeping betwixt the adjacent parts ; as for example, in the urethra of the male, and in the follicles of the finus muliebris. They are irritable ; and when ftimulated by acrid fubftan- ecs, increafe the quantity of their fecretions. }P 4 . Into thefe follicles or cells the leaft arteries (or the Chap. VIII. SECRETIONS. 55 the vafcular flefh furrounding each crypta or cell, and compleating its convexity) open by produced extremi- ties within the cavity of each crypta, into which they diftil or exhale their refpedtive juice; where, being re- tained from the narrownefs of the excretory duct, the more watery parts are drawn up by the abforbing veins, which correfpond to and refemble the exhaling arte- ries ; and thus the follicular or cryptal juices receive a confiderable degree of thicknefs. The truth of this we are taught from the ftrufture of the fimple follicles, obfervable in the tongue, in which both the importing arterial du£fs or pores, and likewife the excretory mouths, are vifible to the eye ; and from the velvet-like tubuli lining the ftomach of birds, in which a fecretory villofity manifeftly hangs in the cavity ; and laftly, from injections, which difcharge a colouriefs wax into the fimple glands. 205. Whether the mucous cavity of fuch a glandule be long or round, it has always an excretory du£t, which, for the moft part, is none of the leaft ; altho’, in the round mucous glandules, the difcharging du£l or orifice be lefs, in refpeCt to the referving cavity, than in others. This difcharging orifice often opens into the common large cavity, into which the mucus is to be poured, without any intermediate duft ; for thus it is in the back of the tongue, and in the fimple glands of the ftomach and inteftines, where they have been de- nominated crypta or cells by Ruyfch. The finufes have often the like fabric, opening without an intervening duCl, as in the urethra of the male. 206. Another k^ind of thefe glandules is, where fimple follicles are folded up together in one common covering, and open with their gaping orifices into one common finus, without forming any true excretory duCf. This fabric we obferve in the tonfils. — Thefe are called conglutinated glands. 207. Other fimple glands of this clafs have an excre- tory duSly by which they expel their mucus ; namely, a narrow, membranous, cylindric, fmall veffel, opening with 96 SECRETIONS. Chap. VIIL with its poflerior orifice into the cavity of the glandule, and with its a'nterior orifice opening into the common cavity for which its mucus is defigned. Thefe excre- tory dudts are of confiderable length in the fubcutaneous and febaceous glands, and in thofe of the palate and wind-pipe. In ibme parts alfo, the pore or orifice, and its duft, are more eafiiy demonltrable, than the follicle or body of the gland itfelf; as in the nofirils, larynx, reSum, &c. 208. In others, again, an affemblage of thefe duels, arifing each from its refpeclive lollicle, run together into one, like the branches of a vein, fo as to form a confiderable excretory canal, common to a number of follicles. To this kind belong the compound mucous glands of the intefeines, fome of the larger in the cavity of the urethra, with the blind or impervious duel or ft- nus at the root of the tongue ; to which, in brutes and birds, add the fringe-hke tubuli of the ftomach. The glands of this fort may be called fnnple ones compounded or continuous : but where they lie only contiguous one to another, they may be called Jimple aggregate or con- gregated glandules ; as are thofe of the fauces, flo- mach, inteflines, &c. 209. The inflammable juices (196.) are feparated by organs differing in their fabric. The fat and mar- row are depofited, without the intervention of glands, from the fmall mouths of the leafl arteries into the cel- lular coat or rather fubflance ; and the fame fat again efcapes from under the fkin by fmall pores or duels, without the afliflance of any glandular follicles. But the ear-wax, and the waxen or fuety liniment of the fldn, are feparated by glands of divers kinds, Moft of the febaceous glandules are vilible enough, wdth an open or naked mouth in the fkin, that leads immediate- Iv into the follicle, without any duel of confiderable length ; as we fee in the external ears, nofe, rings about the nipples, in the female nympha, and the valley or groove that runs betwixt them and the external labia, in the clitoris, and in the male glans and prepuce. Thefe differ Chap. VIIL SECRETIONS. 97 differ but little from the cryptse (205.), except lii their contained matter, which they feparate. 2 10. There are others of the febaceous glands, which have an excretory du£t of a confiderable length, like moft oPthofe in the fkin, which, being feated in the cellular fubflancc, have confequently a duft long enough to perforate the fkin. Thus we fee it is in the face more evidently, where the length of the dud is often to be meafured by the concreted maggot-like fubflance preffed out; the bulk of which demonftrates, that a fol- licle or cell lies under the narrower pore. 2 1 r . There are ftiil other febaceous glands of the kind mentioned 208. in which many cryptae by fmall ducts meet together in one larger excretory dud. Thus in the face, in feveral places, there are large pores in common to a number of fubjacent cryptse. And of this kind are thofe febaceous finks or little inteflines in the eye-lids : and thus it is in the fecretory organs of the mufk-goat, beaver, hyaena, civet-cat, and mufk-rat, which gather their febaceous matter into one common receptacle. 212. The milk, being a humour of its own particu- lar kind, formed of oil and watery juices intermixed, is feparated by conglomerated glandules, whofe fabric we deferibed at 198. Whether the fecretion of the bile be glandular, is controverted ; but there are many argu- ments to perfuade us, that the liver is a mere vafcular fabric, whence the bile distils immediately from the extremities of the porta into the port bUiarii, or roots of the biliary duds, without paffing any cells or fol- licles by the way : and in this we are more efpecially confirmed by the Ruyfehian art of injedion, in which the wax palfes diredly from the porta into the biliary duds, without exhibiting any intermediate knots or ftoppages ; and therefore we fee the milk and bile are both of them much thinner and more watery than the fat, or the febaceous matter which thickens in follicles. 213. It now remains for us to inquire, how, from ®ne common mafs of the blood, the fame variety of pe- O culiar $9 SECRETIONS. Chap. VIII. culiar juices are conftantly fcparated, each in its re- fpeft)ve place ; fo that we never fee milk fecreted in the kidneys, bile in the thymus, or mucus in the feba- ceous glandules. This problem, indeed, maybe folved by one who lhail have previoufiy acquired a thorough knowledge of the intrinfic fabric that obtains in each fecreiory organ. In the mean time, we fiiall here pro- pofe what has been hitherto advanced with certainty on that fubjtcl from any known principles whofe truth we are convinced of. 214. And, firft, the blood itfelf, from whence any liquid is to be fecreted, in the various parts, puts on fuch a charafter or difpofition there peculiar to itfelf, that more particles, of a like nature with the humour, abound in that portion of the blood, which nature in- tends to feparate from it. In the liver, the venous blood arrives with a very flow motion, full of oil, anil full of the femiputrid vapours of the inteflines. To the teflicles, the blood is brought flowly through very long llender and infledled canals, arifing at very fmall angles, and palTing out of the abdomen through a cold tract under the fkin. In the carotids, it is probable that the ftronger, fpirituous, and denfe parts of the blood a- feend ; while whatever is more watery defeends into the abdomen and to the kidneys ; alfo to the forming of the falival juice of the pancreas, and the liquor of the ftomach and inteflines. 215. Another preparation of the blood, towards fe- cretion, is from its retardation in the leaf!: veffels: whereby the red and denfer parts go on by themfelves along the axis of the canal ; while the other lighter and more fluggifh or lefs moving particles recede to the lateral openings or branches, fo as to enter the fe- cretory orifices, which pafs out from the hides of the faid veffels ; and to thefe they adhere by their vifeo- fity. 216. Thefe orifices, though of different diameters, are yet always fmall enough, in their healthy and natu- ral flate, to refufe the red blood. Hence, therefore. Chap. VIII. SECRETIONS. ' 99 we may conclude, that, being enlarged by an increafed force of the heart, they every where admit a good deal of the red blood from the fanguineous artery, which they arife from, and open into, as we cannot with pro- bability fuppol'e them to be much lei's than the red glo- bules. And hence the fame fecretory orifices or duels, which refufe thick injeftions ot wax Or fuet, do ne- verthelefs generally admit thinner liquors injected into the arteries. 7 herefore this is the fir (I and moil fimple mechanifm of fecretion ; viz. that the light or open- ing of the excretory du£l may admit only fuch par- ticles as have their greateft diameter lefs than the diameter of the faid opening. From this reafon only it is, that the yellow arteries convey off a pure liquor from the blood, and that the uriniferous dudts exclude both the red blood and coagulable ferum. But this is not the foie caufe, fince the fame juices are generated by large as by fmall animals. 217. Merely by this law, the fecreted juices may be of many different forts : for thofe whofe lights or tranf- verfe feclions are the leait, will receive only the thinneil juices, as in the fmall veffels of the brain ; and the larger duds will admit water and jelly, while the thick- eft fat will enter the biggefl of all. Moreover, if a number of fecretory organs are formed in a fucceffion from one fecerning artery, each of them having large mouths or duds ; in that cafe, the lafl which come out from the faid artery will receive only the thinneft juices. But if thofe, which are firfl formed in order from the fecerning artery, have fmaller duds, then the lafl only will receive the groffeft juices. It may be ob- jeded, that though the veffels in a foetus are vaftly lefs than in an adult, yet the humours are the fame. But thefe humours which are called fat, bile, lymph, and urine, in the foetus, are vafliy different from the fat, bile, lymph, and water, of a man. 218. From hence only it is, that the fecretions are generally made immediately from fanguineous arteries, without palling the ferous lateral ones, (45.) Thefe O 2 all 100 SECRETIONS. Chap. VIII. all feparate grofs juices ; thick, coagulable, or watery ; as the fat, urine, juice of the ftomach and inteftines, &c. But the fecretions of the other thinner juices are made not from fanguineous, but from fmaller pellucid arteries arifing from the former ; to the fecerning mouths of which, not only no red blood, but no ferum, fat, or o- ther grofs juices, can have admittance. Thus the more thin and pure humours mull neceifarily be feparated ; as for example, in the eye. 219. Perhaps the angle, which the fecretory branch intercepts with its trunk, contributes fomething to fe- cretion. For it is eafily demonftrated, that at right and retrograde angles, only the vifcid andfluggilh juices are expelled by the ftronger force of the particles keeping the middle of the canal ; but the liquids which are about to go off at half-right angles, are thofe which preferve their velocity. For, in living animals, the ve- locity of the blood is greateft in veflels of the acutefl angles, and lefs in thofe of right angles, as men of ve- racity have obferved. That the effect of thefe angles in the veffels is confiderable, with regard to the fecre- tion, we are perfuaded from the ffructure of the body itfelf; fince they form different angles in different parts with refpecl to their trunks, and in fome parts com- pofe net-w'orks. For the fmalleft veffels, in general, refemble the branchings of little trees or flirubs, the trunks and arms of them every way fending out branch- es, but in different angles ; fmall in the large intelfines, but larger in the fmaller inteftines. Thus, in the fpleen, the fmaller red arteries arife fo thick from their trunks, that they relemble a wifp or fprinkler ; in the intef- tines, they refemble pencil-brufiies ; ferpents, in the kidneys ; ftars, in the liver ; a radiated circle in the uvea ; and, in the tefticle, a lock of hair curled up into a button. But we defervedly receive it as a rule, that the Creator never made this diverfity of fabric to no purpofe. We have not as yet, however, any account of thefe net- works that can be fufticientlv depended up- on. Neither does there feem to be any affinity between Tor Chap. Vllf. SECRETIONS. the fabric of the veffel, and the nature of the liquor which it fecretes : and, indeed, thefe net-works are al- moft fimilar to the veins, as if made rather for fhorten- ing the paffage of the blood in fome meafure, than for diverfifying the nature of the fecretion. 2 20. The inflexions of the fmaller veffels, as well arteries as excretory duds, greatly retard the motion of the blood ; in which, therefore, the greater part of the force received from the heart is evidently fpent in changing the figure of the veffels. The repeated in- flexions, therefore, of the fecretory arteries increafe the vilcidity of the juice, by delaying the flux, and giving the parts more time to cohere or attrad each other. But a ftraight courfe of the veffels increafes the celerity of their fluid, whence a copious and eafy fecretion ; but then it makes the fecretion more impure, as we fee in the urine. 22 1. That the fmaller arteries have different de- grees of denfity or firmnefs, there is no reafon to doubt; fince we adually find it fo by experiments in the larger branches. But the denfer the capillary arteries, the more they refifh the light and flowly moving particles, and yield only to the more denfe ones that have a greater impetus. Irritability produces almofl the fame efleds ; for if the fecretory flrainer has a very acute fenfation, it will rejed the grofs humours, and tranfmit the more fluid ones : inflead of mucus in the urethra, it will feparate a thin yellow ferum ; and almofl the fame, inflead of the febaceous matter that lies under the fkin : the quantity of fecreted liquor will alfo be increafed ; as for example, in the tears. 222. Again, the velocity is greatly increafed, if the heart is near ; if the artery is ftraight, or if it is pro- duced with a fmall angle ; alfo, when the excretory dud arifes before the extremity of a larger arterial branch : and it is diminiflied, when the fmall fecretory artery runs a long way capillary, whereby the blood lofes the greater part of its motion in fridion. Finally, from whatever caufe the diverfity may arife, a greater velo- 102 SECRETIONS. Chap. VIII. city increafes the quantity of fecreted liquor, and pro- duces heavy, more grofs, impure liquids ; it alfo gives a degree of fluidity to the fecreted liquors, as it pre- vents the ftagnation, by which they might contraft a vifcofity : but flownefs increafes the attraction and vif- cidity, and renders the fecreted juice more pure ; as the fimilar particles, when brought together, can better at- tract and join each other under a flow motion, fo as to retain the larger canal, while the thinner parts go off by the leffer lateral branches. From hence it is, that, only the impuh'e of the heart being too much increafed, all the fecretions are confufed. 223. Thefe conditions nature is able varioufly to join together or feparate, and impart to every (trainer in greater or leffer degrees ; and thus, by various me- thods, to modify the fecreted humours. Anatomy fur- nifhes an example, if you fliall compare the ftrainer of the bile or femen, which are thick juices, with the ftrainer of the urine and tears, w'hich are fluid ones. 224. From all that has been b.itherto advanced, we may now begin to perceive, that, fince the blood con- tains particles of various kinds ; (bme fluggifli ; others mucous ; ethers coagulable, but fluid ; fome denfe and red ; fome watery and thin ; others fat and grofs (188. et /eq.)”. among all thefe particles, thofe which are the largeft and mod denfe, as the cruor, will go on moft towards the axis of the veffel, fo as to pafs on in a continued courfe from the artery into the trunk of the fanguineous vein (39.) 2 25. Thofe particles w'hich are grofs and fluggifh, as the fat, muff needs go oft' laterally by larger orifices from the fanguineous artery, by fliort du£ls ; for long dufts would make a (top to fuch a fluggifh juice as oil. The phenomena of the adipofe fecretion (19.) agree with this defeription. Such parts as are coagulable, but fpeciftcaiiy heavier than thofe which are merely w^a- tery, kept fluid only while the powers of life are in ac- tion ; thefe pafs off laterally from the red arteries, into the arteries w’hich are not red, but continuous to the red Chap. VIII. SECRETIONS. 103 red ones, and fmaller ; whether thefe pellucid ones are continued on in the nature of trunks, fending off other fmaller branches, like the leaft arteries (41 .) ; or whe- ther they exhale their contents by a fliort extremity, like the veffels of 170. 226. Thin watery juices may evidently pafs off by any veffels continuous with the fanguineous ones, or the leffer ones (44.), provided they be only fmall enough to refufe the groffer juices : and this, wEether they come out from the Tides of the larger arteries; or whe- ther by a long continued courfe, and fending off all the groffer juices by large lateral branches, they, at length, end in a fmaller pellucid canal inftead of a trunk ; as for example, in the eye. To the produdlion of thefe juices, the moff Timple fabric is fufficient ; even a dired con- tinuation of the fecretory artery itfelf into an excretory dud, as we fee in the urine. Therefore, the duds and veffels have here a ftraight and fimple courfe, with few or no inflexions ; and a proportionable velocity as yet holds in the courfe of their contained juices. 226*. Such juices as, being watery, light, but vifcid at the fame time, are confequently fluggifli and lefs moveable ; thefe may be eafily fecreted by fliort nar- row duds of a lefs diameter than to admit the fat, and appended to the fanguineous arteries : and, therefore, it is evident, thefe will be feparated from the blood more abundantly in fome parts of the body than others ; namely, where the velocity received from the heart’s impulfe is lefs, the flexures of the artery more frequent, and where the extent of the capillary artery lhall be car- ried to a greater length. 227. Whether or no ought we to afcribe to each particular part, the ferments, pores, fpecific weights, or filters filled -with their own peculiar humour, and ad- mitting nothing that is analagous to it, which deter- mine the nature of the humours to be generated? One who admits of thefe, ought to confider the great difference there is in one and the fame juice, feparated in the fame part of the body, according to the difference of 104 SECRETIONS. Chap. VIIL of age, courfe of life, &c. The bile in a foetus is ge- nerated fweet ; the femen thin, and without vermicles ; the milk cither none or watery ; the urine watery, mu- cous, and infipld ; the uterine mucus very white ; tiie cutaneous vcffels toll of red juices ; the watery juices reddifh ; and the fat gelatinous. By the fame organs, in an adult perfon, the bile feparated is (harp or acrid ; the femen thick ; the milk butyraceous ; the urine yel- low, thin, and alkalefcent j the womb dilcharges a m.en- flrual blood, and the aqueous humour very clear. But, even in the adult perfon, how different is the urine ? at one time watery ; at another, thick or concocted ; in a fever, high-coloured and heavier, full of falts and oils. The paffions of the mind, which make no other change in the body than that of ftridfures in the nerves, yet wonderfully change the face of the fecretions, and expel even the blood and bile through the vcffels of the fkin. Add to this, the frequent diflurbance of the fe- cretions, and the changes to which they are liable from flight caufes ; fo that only an increafed celerity (hall caufe feveral differing liquors to be fecreted by one and the fame organ : for blood has been known to pals into almofl all the paffages of the fecreted juices ; into thofe of the fweat, tears, mucus of the noftrils and of the womb ; and into the lactiferous, feminal, and urinary duels, as well as the fat. A true milk has been feen feparated by glands in the thigh. When the urine has not been excreted by its natural courfe through fome defeCl of the kidneys, ureters, or bladder, it has pafl'ed by the fkin, exhaled into the ventricles of the brain, or even into the whole cellular fabric. The perfpirable matter of SanCtorius, however thin, is often by cold driven through the nofe or kidneys ; or, by the fame caufe, by fear, or by medicines, is depofited through the excretory villi of the inteflines. That exhaling vif- cid juice, fecreted by the fame organ with the fat, from which it fo much differs, into the cellular fubflance, is depofited, takes place of the fat, is re-abforbed, and alternates again with the fame, (i8, &c.) A falivation fupplies Chap.VIIL secretions. ioj fupplies the place of the Sandborlan or cutaneous exha- lation externally, and of the cuticular exhalation inter- nally. The bile, re-abforbed, appears evidently flow- ing in the veiTels of the eyes. Nor does there appear any thing in the fabric of any of the vifcera or glandules that can fix or maintain the nature of the fecerned fluid. The fpecific gravities of the vifcera and (trainers neither aiifwer, according to the authors who treat of of them, to the fpecific gravity of the humours which they fecrete ; nor are they at all known by experi- ments that can be depended on. 228. It now remains for us to difcover, how the fe- cretions, in a healthy perfon, become pure or uniform. For all the juices that have been lately fecreted (with- out excepting any, even the oil or fat itfelf) have a great many watery particles intermixed ; fo that none of the thicker juices feem capable of being formed, without having a mixture of the thinner watery ones : how then do the femen, bile, fat, mucus ,and other thick juices, depofite their firfl: watery flate, and acquire their proper vifcid condition and other qualities? 229. For this end, therefore, nature has framed glands, with large and fmall follicles or refervoirs, for retaining the fecerned juices, from which the watery parts are required to be feparated, to render the re- maining part more ftrong and vifcid. The mucus, at its firfl depofition, is thin and watery as yet, but little differing from the perfpirable vapours or tears, in whicli flare it diftils into the cavity of the noflrils, wind-pipe, and inteflines. This is not continually difcharging, be- caufe the excretory orifice is lefs than the retaining cell or follicle (196.); and the excretory du£l being fome- times long and (lender, at others repeatedly bent, and turning backwards and forwards, or traufmitted thro' a hard cellular texture, or clofed by fome force equi- valent to a fphin£ler, fo retards the juice that it cannot pafs out but by the afliflance of a preffure ; or perhaps, not without being irritated by the quantity or acrimony of the juice, the follicle preffes out the liquor which P incom,' io6 SECRETIONS. Chap. Vin. incommodes it, by a kind of periflaltic motion. This appears from the morning difcharges of mucus by blow- ing the nofe, coughing up from the lungs, and by fneez- ing after the noclurnal ftagnation. In the mean time, the patulent veins, extended into the cavity of the fol- licle, abforb the more aqueous parts from tlie thin mu- cus, that it may become thicker as it is retained lon- ger ; but if, by the force of fome ftimulus, it be dire£lly difeharged after it is fecreted, it comes out thin and watery. Examples of this we have in the urethra, in the noftrils, and in the ear-wax; as alfo in the bile, which, at its fird reparation in the liver, is watery, and has but little yellownefs or bitternefs. It is, therefore, retained by a large follicle or gall-bladder ; and there digeiled or exalted by the vital heat, and its more thin or watery parts exhaled or abforbed by the veins ; whence the remainder becomes more thick, bitter, and oily. The fame mechanifin takes place in the femen ; which, being referved in the feminal veficle, is there thickened, fo as to be very vifeid after long chadity ; but in repeated venery it is expelled very fluid. In fome places nature has made this receptacle two or three times folded together in one and the fame organ, when her defign was to form a very thick juice. Thus the fe- minal paflfage is in the tedicles reticular; in the end of the epididymis, one large canal ending in a larger ve- ficle: w'hence the velTels at the tedicle are narrow, and fo again are the vas deferens and the prodatic duel. Hence there are nowhere real glandules, except for fecreting a vifeid liquor. And if a vifeid liquor has been fcpai ated from the arteries without a follicle, it al- ways dagnates in a large follicle. The femen, bile, li- quor of the joints, and fat, afford examples of this. 230. A fecerned juice may be likewife changed in its receptacle by the adudon of fome new liquor.. Thus the femen thickens by an affudon of the proda- tic liquor; the chyle is thinned by mixture w-ith the fa- liva and pancreatic juice and that which didils from the villi of the doraach and intediaes, and by an affu- fion CHAP.Vni. SECRETIONS. 107 fion of the bile it becomes alkalefcent ; and again the fynovia or albumen of the joints is tempered by the two kinds of fat (195.) 231. Laftly, whatever is abforbed, can be of ufe to the animal according to its nature, after it is taken into the blood ; as the femen gives a furprifing ftrength to male animals. For the moll part, likcwife, an a- crimony fimilar to that of lixivium is generated, and which alfo hath its ufes, as in the bile and femen. 232. But the great ufe of the follicles and receptacles of glands is to preferve the juice, of whatever kind it 'be, for thofe times in which it is moll neceffary to be employed in the actions of life. Thus the bile is re- ferved for the time of digellion, the femen for due and lawful venery, and the mucus of the nofe is accu- mulated in the night to temperate the force of the re- fluent air in the day. 233. Therefore, as nature has in this way framed machines by which the juices are retarded in the large and fmall follicles, fo {lie has made others to expel them at fuch convenient times. To fome glands Ihc has given particular mufcles for this ufe; as in the te- fticles of brutes, the urinary bladder, and the gall- bladder : or elfe Ihe has placed other mufcular ma- chines round them, which, by ading at convenient times, expel their contained fluids ; as, for example, in the mufcular coat of the llomach and intellines. In other parts llie has added contiguous and incumbent mufcles to promote the difcharge, as in the biventcrs and mafleters of the lower jaw: or elfe flie has again joined to them a kind of nervous irritability, which, being excited to action by an unavoidable Itimulus, opens the Ihut palTages to the milk, feed, tears, &c. ; or being touched by fomething acrid, as already men- tioned, dillils the liquor more quickly ; as happens to the bile, liquor of the flomach and intellines, and to the febaceous matter. RESPIRATION, Chap. IX. . io8 CHAP. IX. Of Respiration. 234. ^ I ' HE bags of the pleura (77, 78.) are exactly X filled by the lungs ; for fo we call the two vlfcera, which are difiinguifhed into right and left, in figure anfwerable to that of the bags theinfelves which they fill, having a broad bafis below, and being termi- nated above at the firfl rib by an obtufe point or cone. The anterior face of them is flat, their fitles convex or round, internally or in the middle concave, forming a concavity fufficient to contain the heart. The right lung is larger than the left ; and more frequently di- vided, or half cut tlv-ough, into three diflincl: lobes or portions ; but the left lung is not fo often divided into three. They are freely fufpended by the great blood- veffels, at liberty on all fides ; unlefs you call that a li- gament which is made by the external membrane of the pleura, departing to the lungs and to the bafis of the diaphragm. Betwixt the lungs and pleura is found a watery or rather ferous vapour, of a coagulable na- ture, like that of the pericardium (82.) ; which vapour tranfudes from the furface of the lungs, continually in the fetus, and not unfrcquently in the adult. This is fometimes increafed to a dropfy, or thickens to a kind of febaceous matter ; or laftly, concreting into fibres, joins the lungs to the pleura. 235. The external membrane of the lungs is fimple, and thinner than the pleura, although continuous to it. It is fpread all over them, from the adhefion of the great blood-veffels of the heart ; yet fo as to be capable 'of retaining wind eafily, without breaking, after being I'eparated from the lungs. The fiune membrane covers the interftice or mediaftinum of the lungs, like a bridge. It is joined to the lungs by a cellular tex- ture. 236. The Chap. IX. KESPIRATION. loc? 236. The ftrufture of the lungs is a heap of lobes feparated from each other by intermediate intervals, in which is extended a loofe cellular fubllance. The firft divifion of them is into two extreme lobes, which are larger ; and one middle one, which is lefs ; yet cohering together : although afterwards they are again fubdivided internally, through a long feries, into leifer lobules down to the lead, till at lad the fmall lo- bules terminate in very fmall membranous cells, which, in adults, are varioufly figured, and full of air, and communicate on all fides with one another. Thefe veficles of the lungs, therefore, do not receive the air by a fingle orifice from the wind-pipe, as into an oval grape or vial ; but the air, exhaling from the lead branches of the faid wind-artery, is admitted in fuch a manner into their irregular fpaces, that it freely fpreads through them from any one part of tiie lungs into all the red, and returns again in like manner. This is demondrated by inflation, which drives the air even through the lead branches of the wind-pipe into the fmalled lobes ; from whence it readily paffes into all the red. Nor, in man and fmaller animals, is the cellular fabric of the intervals lliut up from the veficles of the lungs, nor are the lobes furrounded by any pe- culiar membrane ; for in the larged, as between the air-veficles and thofe cellular fpaces furrounded with lobules, there is no commerce. 237. The air is driven into thefe veficles thro’ the wind- pipe, which arifes from the larynx (hereafter to be de- feribed), and from that only receives its air. The fird part of this wind-pipe is fingle, and defeends along the fmooth bodies of the vertebrae of the neck^ partly flefliy and partly cartilaginous ; namely, within the cellular fub- dance that furrounds the wind-pipe, follows a canal, made up by a fucceflion of cartilaginous and mufcular rings. Thefe are thin and cladic ; flatter and thicker in their foremod part, but thinner in their poderior extremities, which are conjoined together by drong tranfverfc lid RESPin ATION. Chap. n. tranfverfe mufcular fibres, which, adhering firmly to each extremity of the cartilage, complete the circle. But the lowermoft circles are lefs ; the uppermofi; of- ten augmented by an appendix, the next again perpen- dicular to the divifion. 2^8. The flcfiiy rings, alternately placed with the cartilaginous ones, are made up of red mufcular fibres. Some of thefe are tranfverfe, connecting the detached ends of the annular cartilages ; others defeend from each upper to the next lower ring. But other muf- cular fibres again, defeending downwards from the cri- coide cartilage, and having reached below the firft di- vifion of the bronchia, vanifh within the luns[s. The tranfverfe fibres contract or leffen the diameter of the wind-pipe ; the hingitudinal ones render it fhorter. Alfo within the lungs, betwixt the imperfect rings, is found a fort of mufcular fabric, but lefs uniform. 2 In the cellular coat which furrounds the muf- cular one, but efpecially in the back part of it, a- long the pofterior interval that is betw'ixt the carti- lages, are placed numberlefs fimple glands, which open by very fmall ducts, like pores, into the cavi- ty of the wind-pipe : by which pores they depofite a watery and pellucid mucus into that cavity ; which mucus, being without the leaft acrimony, not coagu- lable into a hard fubftance like the humour of the eye, is of the greatefl; ufe in defending thefe moft fenfible membranes from being injured by an impure air, full of particles, which, by their mechanical figure or che- mical acrimony, might be very troubkfome. Laftly, the internal tube of the wind- pipe is compleated or lined by a membrane, which is continuous with that of the mouth, fmooth, foft, and very irritable. The fame cellular texture furrounds it which anfwers to the mufcular coat. 240. The veflels of this part of the whole wind- pipe, in the neck, come from thofc of the lower tlty- reoids ; in the thorax, from other fmall branrh;, s of the fubdavian trunks, or the mammaries, or the (htah Chap. IX. RESPIRATION. ni chlah properly fo called. Its nerves are numerous from the recurrent and intercoflal ones. 241. In the upper part of the thorax, the wind-pipe is received between the laminae of the pofterior part of the mediaftinum ; and at the third vertebra, or a little above, is divided into two fimilar branches refeinbling the trunk itfelf, and formed like that of imperfeft carti- lages, alfo furnlfhed wirh fimilar glandules ; each of which branches enters the lung to which it correfponds, only the right is fomething Ihorter and larger than tlie left. Having entered the lungs, the cartilaginous rings change into fragments, which become more and more difform, gnomonic, angular, triangular, and inter- mixed with a larger portion of the membrane, till, at length, the cartilages decreafing, the laR branches of the bronchia become merely membranaceous. 242. Its lad branches are invifible, w'hich exhale the air into the cellular fpaces of adult lungs, and like- wife receive the watery vapours exhaling from the ar- teries into the faid fpaces ; from whence they arc thrown out by exfpiration. 243. The blood- veflels of the bronchia are the arte- r'uz & vena bronchiales. The former are almofl con- ftantly two j one coming from the upper intercoflal of the aorta, which is diftributed either to the right only, or to both the lungs ; the other, from the trunk of the aorta itfelf, goes to the left lung. Sometimes there are more than two bronchial arteries to be feen ; as w’hen there are three, by the addition of a fecond from the aorta. But fometimes again there is only one artery in common. The thoracic part of the bronchi fituated without the lungs, has its proper velTels from the aorta, the fubclavian, mammary, or intercoflal. The bron- chial veins are mod commonly two ; the right from the vena azygos, the left from a peculiar branch of the fubclavian vein and the left fuperior intercodal. Thefe blood-veffels travel together with the branches of the wind-pipe ; and defeend into their membranes in fuch a raantierj that the pulmonary arteries, irj their way. 112 RESPIRATION. Chap. IX. inofculate with their contiguous arteries, as the veins iikewlfe communicate with each other. There are feme inftances where the pulmonary vein itfelf has given fmall branches to the lungs, to the wind-pipe, and to the fur- face of the lungs. 24 ^^. But there are other larger veflels belonging to the lungs, called the pulmonary artery (deferibed io6. 108.), and the pulmonary vein (i 10.) The great ar- tery, in the fetus larger than the aorta, and in the a- dult but little lefs, has two branches ; the right larger but fhort, the left narrower and longer. In the fetus, the trunk itfelf is continued into the defeending aorta, and is known by the name of dudus arteriojus. In an adult, that trunk degenerates into afolid ligament. The four pulmonary veins accompany the arterial branches and the afpera arteria of the wind-pipe in their courfe through the lungs, furrounded with a good deal of cellular fubftance ; which fubftance, being increafed, at iaft compofes the lungs themfelves. Within this cellu- lar fabric, and likewife upon the ultimate fpaces or cells, the air-veflels and blood-veflels are fubdivided, ipread, and interwoven like the mefhes of a net ; and here the fmall arteries exhale a plentiful vapour into their cells, and the veins abforb a w’atery vapour from the fame cells. Hence water tinctured, the whey of milk, or a thin waxen injeftion, being urged into the pulmo- nary artery, flows w'ith a froth into the wind-pipe ; or, on the contrary, being urged from the wind-pipe into the lungs, they penetrate into the pulmonary arter)'. In like manner, injeftions pafs from the pulmonary vein to the wind-pipe ; or from thence again, they may be forced into the veins. Laftly, a liquor injected by the arteries, readily enters the pulmonary veins ; and, the reverfe. 2^5. The lymphatic veflels, as in other parts, form a net-work upon the furface of the lungs, from whence there are branches conveying the lymph to the cavity at the back part of the mediaftinum, and to the fmall glands which lie behiod the oefophagus, opening at Chap.IX. respiration. 113 laft into the thoracic du£t. The anterior pulmonary nerves are fmall, but the pofterior ones fomewhat lar- ger : they come from a nerve of the eighth pair ; and there are alfo fome fmall nerves to the lungs from the recurrent, and likewife from the cardiac plexus, which enter together with the large blood-veffels. Hence the lungs have but little fenfation ; that of the little nerves, how^ever, divided after the manner of the bronchia, is very acute. Nor are the lungs of an irritable nature. 246. The quantity of blood which enters into the lungs is exceeding great, equal to (or even perhaps greater than) that which is fent in the fame time through- out the reft of the whole body ; which, therefore, de- monftrates fome very confiderable ufe proper to this vifeus. And that this ufe depends manifeftly upon the air, appears from the univerfal confent of nature, ia which we fcarce find any animal without breathing; al- fo from the ftrudure of the lungs in the fetus, in which, for want of air, they are ufelefs, receiving only a fmall portion of the blood, which the pulmonary ar- tery condufts from the heart. We are now, therefore, to fpeak of refpiration, by which the air is drawn into and expelled from the lungs. 247. The element of air appears, from the principles of philofophy, to be an elaftic and fonorous fluid, with a fpring which cannot be deftroyed. But the at- mofpherical air, which we commonly receive into the lungs, is impure, filled with a great quantity of watery and other vapours, alfo with falts and the univerfal acid, with the feeds of plants and animals, and other foreign matters, but in very minute particles ; fo that it weighs 859 times lefs than water, and a cubic foot of air weighs between 6 10 and 694 grains. This air, which furrounds the earth on all fides, being prefled by the incumbent columns of its own mafs, perpendicularly, laterally, and in all diredions, enters wherever it meets a lefs refiftance, and with a confiderable force, as appears from experiments made with empty or exhaufted vef- fels, and by the air-pump, fo that its preffure on the hu- man body is not lefs than 3000 pounds weight. It is II4 RESPIRATION. Chap. IX, repelled chiefly by the pores of the membranes, which yet are permeable by water : it likewife penetrates oil or mucus with difiiculty. 248. This air is excluded from all parts of the hu- man body by the furrounding clofe fliin, which, even when dried or tanned, is impervious to the air; but more fo, as under the ikin is placed the fat, making an equal refiftance to the narrow openings of the abforb- ing veflfels. It, therefore, now remains for us to in- quire, why the air enters the lungs of an adult perfon ; for with this they are in a manner conflantly full, and of courfe are equally preffed, and refilling againft the weight of the whole atmofphere : but that the lungs always contain air, is evident; becaufe, however clofe you comprefs them, they will be llill lighter than wa- ter ; and even in the fetus, after they have been infla- ted but a few times, they always fwim ; vrhereas, before breathing, they fink to the bottom of water, if they have as yet not given admittance to the air. 249. The equilibrium of the air’s preflfure being re- moved in any ^ace, it conflantly defcends or flows that way where it is leafl refilled (247.) But air that is denfe and heavy will defcend more eafily than fuch as is light, whofe force fcarce overcomes that of the air which is already in the lungs, nor is able by the fame force to overcome the refiflance of the bronchia and force by which the lungs comprefs the air contained in them. Hence an animal lives better in a denfe than in a light air : although that kind of air is always moll tolerable, which is pure at the fame time that it is light; fuch as that of the highefl mountains of the Alps. Therefore, for the air to enter the lungs, they mull make a lefs refiflance to it than before ; namely, the air, which is already in the cellular fabric of the lungs, mull be ratified : but this elFed will follow, if the ca- vity of the thorax, in which the lungs are contained, and which they exaflly fill, be dilated. Thus the air, which is always in the lungs, expands into a larger fpace, by which, being weakened in its fpring, it u^es Chap.IX. respiration. 115 makes a lefs refiftance to the external air ; and confe- quently a portion of the faid external air defcends into the lungs, fulficient to reftore the confined and rarefied air, filling the lungs to the fame denfity with that of the external air. 250. We mull therefore defcribe'the pov/ers which dilate the thorax to produce this effeft. The bread or thorax is a fort of cage made up of bones, mufcles, and cartilages ; being almoft of the lhape of an oval tub, fomewhat comprefled before, but behind divided by an eminence, whofe hoops are the ribs, which are of a re- markable ftrength. In the lateral parts of this cage are placed the lungs ; in the middle and lower part lie the pericardium and heart ; after which it is taken up by ibme of the abdominal vifeera. 251. The bafis of the thorax is formed by a column, a little crooked, and gibbous on the upper and back part ; and likewife, in that part of the bafis which is up- permoft, the fame is very much behind the others into which twelve vertebree coalefce. They coalefce, how- ever, by the union of their bodies into a fingle column, which is prominent in the forepart between the two ca- vities of the bread; divides the right from the left; and is plane in the forepart, and broad towards the fides. A {light finuolity receives the ribs in that place where the arch feparates from the body. They are bound to- gether into one column, as well by the eladic plate in- terpofed between every two bodies, and coalefcing with both 5 as by other ligaments and fpines lying upon one another, and the joining of the ribs, by which means no motion can happen among thevi without the greated difficulty. The fides of the bread are made up of twelve ribs. Thefe are in general bent in the form of an irregular arch, having a great curvature la- terally and backwards, but extending in their forepart towards a right line. The bony parts of the ribs lie - fufficiently parallel with each other; the greated part of the rib is bony, round, and thick backward, but thin and flat forw’ard. The other part forward is com- 0^ 2 pleted ji6 RESPIRATION. Chap.IX. pleted by a cartilage ; which in general continues the figure of the rib, growing in a flat broad concavity of a nature different from the bony part ; and which does not change in*o bone, unlefs in extreme old age. 252. The pofterior and bony thick part of each rib terminates in a head ; along from which, in the body of the uppermoft and two lowermofl; ribs, runs a cavity or groove, formed in the other ribs, betwixt every two ad- jacent margins, which lie one towards the other. The vertebrae are tied to the ribs by ftrong ligaments, of which the principal fpread from each rib like rays into the next adjacent vertebra, other ligaments tie the tranf- verfe procefs to the tubercle of the rib, and others tie the ribs one to another and to the tranfverfe procefles at the fame time. Moreover, betwixt the angle of in- curvation and the juncture with the vertebrie, each of the ten upper ribs fend out a protuberance, which, being articulated with the plain fide of the tranfverfe procefs of each vertebra, are fo tied by fliort and ftrong liga- ments to that procefs, that the rib has liberty to make a fmall afeending and defeending motion, but with a confiderable degree of firmnefs. 253. Among thefe anterior cartilages, the feven up- permoft: reach to the fternum, and enter into the lateral cavities, which are incrufted with a cartilage in that bone, to which they are alfo made faft by fhort liga- ments. Of the five remaining ribs, the uppermoft is faftened to the feventh preceding, and that to the next lower, by a ftrong cellular texture, by which they form a continuous margin, which is at laft alfo faftened to the fternum. The fame are connected to one another both by proper ligaments, and cartilaginous appendiees joined with them through the cellulofuy : the two lower- inoft are free, and connedled only with tlse mufcles. Thefe inferior cartilages are united to one another and to the fternum by ftrong ligaments. 254. The firft rib is the fliortcft, but more folid than any of the reft. As they follow in fuccefTion to the feventh and eighth,every two and two ftretch them- felvcs Chap. IX. RESPIRATION. 117 felves into longer and more moveable circles. The eighth is the longefl of all ; and from thence, the lower down they are, they grow continually fhorter. 255. The direftion of the upper rib is defeending; but the fecond rib joins the fternum almoft in a right angle, while the others afeend both to the vertebrae and t-o the fternum, but more to the latter. But the bony part of the ribs is placed in fuch a direction, that the uppermoft have their fides in the fore part very much declined forward, almoft tranfverfely. In the third ribs it is placed almoft perpendicularly; in the middle ones, it projeds a little outward in the lower part. Befides, the ftrength of the different ribs is very different. The uppermoft, being fhort, rather grow into the fternum than form a joint with it; and being tranfverfe, and often as it were welded together, they make a very ftrong refiftance. From thence the mobility increafes downwards, till the loweft rib, adhering only to muf- cles, has the moft eafv motion. 256. The fternum in general is a thin fpungy bone altogether, one in adults, but is varioufly divided in the fetus. Its upper and broader part refembles an octa- gon ; and is articulated with the clavicles, which are jointed very clofely with the triangular head of the fter- num, and with the firft rib on each fide. The other part which is longer and narrower grows broad down- wards, and its fides receive the ribs each into its pro- per angular cavities. The lower part, which is leffer and Ihorter, imitates the obtufe figure of a tongue. This is continued into a detached appendix, partly bony, and partly cartilaginous, of a changeable figure, which they call the enjiform cartilage ; and which is found of va- rious fhapes, fometimes being obtufe like a little tongue, fometimes pointed like a fword, fometimes bifid, and fometimes perforated. 257. In order, therefore, to dilate the feat of the lungs, and thus to put the body in fuch a ftate that the external air may rufh into the lungs, it is neceffary for the thorax to be elevated. For thus all the fe£tions of the ii8 RESPIRATION. Chap. IX. the thorax form right angles, and its capacity is increa- fed. This motion is performed by various mufcles, •which either operate conftantly, or only at certain times. The intercoftal mufcles, therefore, all of them a£t per- petually in elevating the ribs. By this name "we un- derfland 22 mufcles; of which 1 1 are external, or next the fkin; and as many internal, feparated from the pleura only by fat or cellular fubftance. The beginning of the cuter intercofials is at the poilerior articulation of the ribs (252.); but the termination of them is in the ante- rior bony part of each rib, at fome diftance from the cartilage, in fuch a manner, that the remaining fpace betwixt the cartilage and flernum to the mufcle is filled by a tendinous expanfion. The diredlion of thefe muf- cles is fuch, that the fibres defeend obliquely forward, from the lower edge of the upper rib to the upper edge of the lower rib. And that their aftion is to elevate the ribs, all authors unanitnoufly agree; becaufe they thus defeend from the upper lefs moveable to the lower and more eafily moveable rib, in fuch a manner, that their lower point lies more diflant or remote from the hypo- mochlion or point of motion, which is in the coftal arti- culation with the vertebrae, confidering the rib as a lever. 258. But the internal intercofials arife at fome di- flance from the vertebrae, almofl at the outer tubercles of the ribs beforementioned (252.). From thence they proceed as far as the flernum, into which the upper- mofl of thefe mufcles are inferted above. The diretlion of thefe is contrary to that of the former, except the anterior part of the firfl or uppermofl of them ; fo that they defeend from the lower margin of the upper rib backward, to the upper edge of the lower rib forwards. Therefore fome doubt of their a«flion, becaufe their lower part is inferted into that portion of the rib which is nearefl its articulation with the vertebrae, and which therefore feems to be the leafl moveable : however, they elevate the ribs notwithflanding this ; for the great firm- nefs or immobility of the upper rib, exceeding that of the lower, is evident from the articulation, weight, and H- Chap. IX. RESPIRATION. 119 ligaments there formed, which furpafles that mobility, arifmg from the greater diftance of the center of mo- tion. This appears from the diifedion of living animals ; in which we fee the inner intercoflal mufcles operate in the elevation of the ribs, and reft in the depreffion of them ; alfo from a flexible thread fixed to the rib of fome human fkeleton, and drawn in the fame direction with that of the fibres of the inner intercoflal mufcles, by which means the lower rib will be always approxi- mated towards the upper. The greater firmnefs alfo of the upper ribs proves this, as they ferve for a fixed point to the lower ones ; for the fir ft or upper moft ribs are from eight to twelve times firmer and lefs moveable than the lower true ribs ; but the difference of diflance in them, from the center of motion, is fcarcely the twen- tieth part of the length of their whole lever. Laftly, the elevating power of the internal intercoflal mufcles appears plainly by experiment in a dead fubjedl, whofe thorax, being raifed or inflated, thofe mufcles fwell or contraft. 259. By the aftion, therefore, of thefe mufcles, the thorax is elevated, not altogether as one machine, nor would refpiration be affifted by fuch a motion ; but the ribs turning upon their articulations, though behind they are but little moved, yet the fore-part of their ex- tremities thereby defeend and form larger angles both with the flernum and vertebra ; but from thence in the- middle of their arches, by afeending, their lower edges are drawn upward. At the fame time, the flernum is thrufl out forward more from the vertebra and from the ribs. Thus the ribs are both removed farther from the vertebra, and the right ribs depart from the left; and the diameter on both fides, betwixt the right and left ribs, betwixt the fternum and the vertebra, is in- creafed almofl to two lines ; and therefore this enlarge- ment, following in every imaginable feftion of the tho- rax, will fufficiently dilate the cavity of the breafl. This aftion of the ribs is more particularly complete in wo- men, &nd in men who have no fhortnefs of breath. Thefe 120 respiration. Chap. IX. Thefe effcfts are produced leaft of all by the firft ribs, but more by the following ones. In very flrong in- fpiration,the ribs defcend both behind and before ; and, along with thefe, the fternum and the fpaces between the cartilage are leffened. But this dilatation alone is not fufficient for healthy breathing ; nor is it fo confpi- cuous or evident in men ; although, in them, the in- tercollal mufcles, by retaining and elevating the ribs, very much affift the infpiration in a tacit manner, while they afford a fixed point to the diaphragm, that the whole force of that mufcle may be fpent, not fo much in depreffmg the ribs, as in urging down the abdomen. The greater part, therefore, of the fpace which the thorax gains in infpiration, arifes from the adion of the diaphragm. 260. By the diaphragm we underlland a mufcle expanded in a curvilineal plate, by which, in general, the pulmonary bags are feparated from the abdomen in fuch a manner, that the middle and tendinous part of the feptum is nearly the higheft, and fupports the peri- cardium : its lateral parts, which arife from the folid parts of the thorax and loins, are every where lower ; but the lowed of all are thofe which lie moll backward. The ilefliy portions of this mufcle arife before from the inner or pofterior face of the enfiform cartilage, and ifrom the feventh, eighth, ninth, tenth, eleventh, and apex of the twelfth, rib ; after which follows an interval, in which the naked pleura lies contiguous to the peri- tonaeum. From thence the mufcular appendices of the diaphragm, which are much the ftrongeft part of it, being colleded on each fide into two, three, or four round mufcular portions, arife fielhy from the tranf- verfe procefs on each fide of the firff vertebra of the loins, and from the fide of the body of the fecond ; tendinous from the middle of the body of the fecond, third, and fourth, and with cartilages placed between them, always higher up in the left fide, but lower down in the right. 261. All thefe fibres (26c.), becoming tendinous, form Chap. IX. RESPIRATION. izt form the centre of the diaphragm, which refembles, in figure, an obtufe index of a fun-dial, having the middle of the larger angle fupporting the pericardium, while the lateral angles or wings defcend backward, the left being narrower than the right. This centre of the dia- phragm is more moveable and at liberty than the reft; except in the middle of its tendinous part, near the flelhy margin, where the incumbent heart makes a re- liftance; but the lateral parts and the flefhy portions belonging to them are the molt moveable. The fibres of this tendon form a moll beautiful web, principally indeed on the upper part; which ftretches from the flelhy part of each mufcle to the flelhy part of the op- pofite one : thence remarkable inferior fafciculi are fent off tranfverfely to the right and left, and alfo back- wards, which lall portion is the uppermoft. 262. There are two holes in the diaphragm; of which that on the right fide of its tendinous part is fomewhat fquare, and circumfcribed by four llrong ten- dinous portions ; the left, which is elliptical, lies betwixt the right and left flefhy portions, which arife from the middle of the bodies of the vertebrae of the loins : un- der this opening they deculfate and crofs each other once or twice, but above they end in the tendon. This left opening is therefore drawn clofe together in the contradion of the diaphragm, while it is pro- bable that the other opening remains immoveable. The tendons are but little changed in the motion of the mufcles. 26 g. The llrucfure of the parts, and the difledion of living animals, demonllrate, that the flelhy portions of the diaphragm, which on all fides afcend from the firm parts to the middle and more moveable portion of it, do, by their contradion, deprefs the fame, and by that means draw downward the lateral bags of the tho- rax, which contain the lungs (77.) ; and, by this means, the perpendicular diameter of the thorax is confiderably increafed. The flelhy parts are more deprelTed ; the tendon lefs, both becaufe it is fixed to the pericardi- R um, 122 RESPIRATION. Chap. IX. um, and becaufe its own fubftance doej not contract. Even the oefophagus and vena cava are contracted, while the diaphragm exerts its adion. So that the dia- phragm almoft alone performs the office of refpiration in a healthy man who is at reft •, as alfo in that thorax whofe ribs are fradured, or the fternuin burll, or where the perfon will not make ufe of his ribs by reafon of pain. The force of the diaphragm alfo, in dilating the bread, is greater, according to the calculations that have been made, than all the reft of the powers which con- tribute to refpiration. A ftrong infpiration is confined to this place ; becaufe, during the height of the exer- tions of the diaphragm, the lowermoft ribs are brought inwards, and thus far the thorax is ftraitened. Left this fhould always happen, the intercoftal mufcles inter- fere in ordinary infpirations ; in very great ones, they are inferior to the diaphragm. The phrenic nerve, which is more eafily irritated than in moft other mufcles, forces the diaphragm to perform its office. The lungs theinfelves are altogether paffive or obedient to the adion of the air, ribs, and diaphragm ; to which they are preffed into clofe contad on all fides, as thro’ a large wound ; and when the thorax is denudated by the knife, leaving its capacity entire, the lungs appear filling out the pellucid pleura and diaphragm. 264. But in larger infpirations, which receive a greater quantity of blood driven into the lungs, and when there is any obftacle or difficulty oppofed to the adion of the lungs themfelves ; in thofe cafes, feveral other powers confpire to elevate the thorax ; which powers are in- ferted either into the thorax, clavicles, or fcapulas ; fuch as the fcaleni mufcles, trapezii, cervicales defcendentes, ferrati fuperiores, and pedorales ; together with the fmall elevators, of which a more ample defcription may be had from profdfed fyftems of anatomy. 265. We have hitherto furveyed the powers which are able to increafe the capacity of the thorax in all its three dimenfions (263 and 259.) By thefe the cavity of the breaft is dilated, fo that it comprefles the lungs left Chap.IX. respiration. 123 lefs than before : the lungs then flrive to diffufe them- felves over that fpace, feeing they are never deftitute of air, which expands itfelf by its elafticity as foon as the prelfure is taken off. Without that mufcular force, the lungs have no proper power of their own by which they are capable of attrading air : and, even when they are moll full of air, by having the afpera arteria clofed, the animal vehemently attempts to infpire, by the efforts of its intercoflal mufcles and diaphragm. It therefore re- mains, that the air (247.), which is a heavy fluid, and preffed on all Tides by the incumbent columns of the at- mofphere, muft now enter the thorax by that greater force which it has over the little rarefied air already in the lungs ; or yet more powerfully, if they contain no air at all ; but none if the air admitted through a wound in the breafl; preffes upon the lurface of the lungs. In. this adion, therefore, which is called infpiration, the bronchia are every way increafed, both in length and diameter ; becaufe all the diameters of the thorax are increafed t but, in this aft, the inflated lungs always follow clofely contiguous to the pleura, without leaving any intermediate fpace. At the fame time, the pulmo- nary blood-veffels, which are wrapped up, together with the bronchia, in a covering of the cellular fubftance, are likewife with them extended in length, and fpread out from fmaller into larger angles ; by which means, the circulation is rendered eafier through them. While this is performing, the velicular fubftance, or flefli of the lungs themfelves, filled out with air, increafes thofe fpaces through which the capillary blood-veffels of the lungs make their progrefs ; whereby the veficular pref- fure, upon each other, and upon thofe veffels adjacent, is leffened; thus, therefore, the blood will flow with greater eafe and celerity into and through the larger and fmaller veffels of the lungs. Hence, a dying ani- mal is revived by inflating its lungs, and facilitating the paffage of the blood to the left ventricle of the heart ; and thus people feemingly dead by being kept a long time under water, are again recovered. But as for the R 2 preffurc 124 RESPIRATION. Chap. IX. preffure of the air upon the blood in the lungs in this adion, it is fo inconfiderable as not to deferve our no- tice, as being goo times lefs than the force of the heart ; nor can it ever urge the air into the blood, as it eafily may be forced by art with a fyringe. 266 . It is by fome queftioned, whether there be not air betwixt the lungs and the thorax ? and whether this air, being rarefied in infpiration, is not afterwards con- denfed, fo as to comprefs the lungs, and caufe exfpira- tion ? And they again alk, whether this opinion be not confirmed by the inftances of birds, in which we find this matter to be truly fo ? But we fee every thing con- curs to confute this opinion : for, immediately behind the pleura, in living quadrupeds, as well as in dead hu- man bodies, the lungs are contiguoufly vifible to the naked eye, without any intermediate fpace betwixt them; but the pleura being perforated, the lungs are immediately, by the contiguous air that enters, prelTed together towards the vertebrae. In birds, indeed, the lungs, being pervious to the air, admit it into the cavity of the thorax through large holes in their fubftance. But in thefe there is a manlfefi: fpace betwixt the lungs and the pleura. Large wounds, admitting the air only into one cavity of the thorax, diminifh the refpiration ; but fuch wounds, as let the air into both cavities, quite fuffocate or fupprefs the refpiration. The thorax being opened under water, fends out no bubbles of air through the faid w'ater ; but in birds it does, becaufe they have air in their thorax. The imaginable fpace betwixt the lungs and the thorax is always filled up by a watery or ferous vapour, or elfe by the fanm vapour condenfed into a w'atery lymph. If the lungs adhere, they injure the refpiration but in a final! degree ; which ought entirely to ceafe, if it required an intermediate air betwixt the lungs and thorax. Finally, the exter- nal air, being admitted to any of the internal mem- branes of the human body, deftroys their texture, if they are not defended by a plentiful mucus; of which we can find none upon the furface of the pleura. 267. But Chap. IX. RESPIRATION. 125 267. But refpiration, whether by the admixture of a fubputrid vapour, or by fome other method, cer- tainly vitiates the air, and renders it unfit either for in- flating the lungs or fupporting flame ; and laflly, it de- prives that element of its elaflicity. It is probable that this happens from putrefaction, feeing the air is ren- dered peflilential by a crowd, and fevers of the moft malignant kind are thus generated in a few hours. Seeing this is the cafe, we are certain that the air is vi- tiated in the lungs; lofes its elaflicity; and thus cannot keep the lungs diflended, fo as to tranfmit an increafed quantity of blood through the dilated pulmonary arte- ries into the veins. Nor can the will dilate the breafl beyond certain bounds, or afTifl tflat paflTage of the blood in an unlimited manner. A ftate of body there- fore wiil take place, in w^hich the blood cannot pafs through the lungs. .268. Thus a new refiflance to the blood continually coming from the heart is generated ; and in long re- tentions of the breath, as in making violent efforts, the venous blood, efpecially of the head, flagnates before the right ventricle of the heart when fhut, becaufe it cannot evacuate itfelf into the lungs ; and thus fwells up the face with rednefs, fometimes burfts the veins of the brain, neck, inteftines, kidneys, and laflly of the lungs, and right auricle of the heart. This is thecaufe of prodigious anxiety of mind ; this alfo is the caufe of death in compreffed air, in drowned people, and fuch as are firangled, which is much more fudden than is commonly imagined. A living perfon therefore, that he may remove thofe inconveniences v.'hich flow from an obflrudlion of the paflage of the blood, flack- ens the powers of infpiration, and excites thofe of ex- fpiration, which free the breafl from an air too greatly rarefied. 269. Thefe powers are, firfl, the elaflicity of the ribs, which being drawn upwards out of their natural fituation, as foon as the powers which elevated them ceafe to ad, fpontaneoufly place themfelves fo as to make 126 RESPIRATION. Chap.IX. make more acute angles with the fternum and verte- brae. To this end conduces likewife the elaflic force of the bronchia and veficles dillended with air, which ftriveto contrad theinfelves. Hence exfpiration is per- formed more eafily and quickly than infpiration ; and hence it is the laft aftion of dying people. 270. To this alfo contribute the oblique mufcles of the abdomen, together with the flraight and tranfverfe ones. The former of thefe are, in one part of them, faftened to the lower ribs ; and, in another part, they are attached to the os pubis and ilium, as a fixed point with refpect tothebreall. Therefore the ftraight mufcles, being contracted, deprefs the arch or convexity into which the abdominal vifcera are thrufl by the dia- phragm, and bring the fame nearer to a ftraight line : at the fame time, the abdominal vifcera are prefled by thofe mufcles upward and backward againft the dia- phragm, which alone is able to give way ; and yield up into the thorax, which at that time is rendered fliorter. The oblique mufcles, for the fame reafons, comprefs the lateral parts of the abdomen, and urge the liver and ftomach backwards, and prefs them to- wards that place where there is the leaft refiftance. Laftly, they draw down the ribs, which were before elevated by the intercoftals. The tranfverfe mufcles, indeed, do not draw down the ribs ; but they pull the cartilages of the falfe ribs a little inward, and render the whole capacity of the abdomen lefs, while at the fame time they prefs the vifcera againft the diaphragm. Along with thefe we may reckon the powers of the fternocoftal and long intercoftal mufcles, which are called depreffors. By this joint force the fuperior ribs defcend; but the middle ones more, the uppermoft lefs, the loweft moft of all ; and the fame are brought inwards by their margin ; the cartilages afccnd, and return into acute angles with the fternum ; and the fternum itfelf returns backw^ards with the ribs. By thefe means the thorax, contrary to its former ftate (259.), is every where rendered narrower and {hotter. Chap.IX. respiration. 227 fo 9S to expel as much air out of the lungs as is fulE- cient to relieve the uneafmefs caufed by its retention (268.) 271. In more powerful refpirations, when the infpi- rations are made greater, the exfpirations are likewife increafed by the afliftance of fome other powers, as of the facrolumbalis, longiflimus and quadratus raufcles of the back and loins. This force, by which the air is blown out of the lungs through a tube, is fufficient to carry a leaden bullet, weighing above a dram, to the diftance of 365 feet ; which force is equal to a third part of the preffure of the atmofphere. Bat, in a healthy perfon, the mufcles of the abdomen alone fuf- fice to an eafy exfpiration, in which the lungs are not fo much emptied of air as they are by a violent effla- tion. 272. The effeds of exfpiration are a compreffure of the blood-veffels in the lungs, a redudion of the bron- chia into more acute angles, a preffure of the reticular fmall veffels by the weight and contad of the adjacent larger veffels, an expulfion of the corrupted blood from the lungs; by which means part of the blood, hefita- ting in the capillary arteries, is urged forward through the veins to the left fide of the heart, while at the fame time that part of the blood is refilled which flows in by the artery from the right ventricle. Ex- fpiration, therefore, will flop the eafy paffage of the blood through the lungs ; and, when the whole thorax is compreffed together, repels the venous blood into the veins of the head, and fills the brain and its fi- nufes. 273. In this manner a frelli neceffity follows for re- peating the refpiration ; becaufe the collapfed veffels of the lungs refill the blood repeatedly expelled from the right ventricle of the heart. And this makes another caufe of death, in thofe animals w'hich expire in veffels cxhaulled of air: for, in fuch, the lungs having the air drawn out from them, appear denfe, folid, and heavier than water , whence they arc rendered impervious to 128 RESPIRATION. Cha? . IX. the blood. Of the fame kind is the death of thofe who are killed by lightning, and perhaps by the noxious va- pours of caverns. Thus, therefore, by the power of a moft wife fabricature, the organs of cxfpiration are relaxed fo foon as that uneafinefs is perceived which arifes from the hindrance of the blood’s courfe thro’ the lungs ; and thereupon the powers of infplration arc excited into aftion, whereby the courfe of the blood through the lungs is rendered free and quicker. 274. It is by fome queflioned, whether or no there are not other caufes of alternate refpiration ? whether or no we may hope for any difeovery in this matter, by compreffing the vena fine pari, the phrenic nerve, or intercepting the blood fent to the brain ? But thofe are repugnant to comparative anatomy ; by which we al- ways find the fame alternation in the breathing of the animal, independent of any fuch nerve or vein. Whe- ther or no refpiration is from the alternate contraction of the antagonill mufcles, among which thofe of ex- fpiration rela.x the others of infpiration, and the reverfe? But in this manner, all the mufcles of the human body are perpetually in an alternate motion. 275. From what has been hitherto faid, it appears, that refpiration is unavoidably and abfolutely neceffary to life in a healthy adult perfon ; becaufe, whether the lungs remain long in a ftate either of exfpiration or in- fpiration (273. 278.), we fee death will be the confe- quence. Therefore no animal, that has lungs like our- felves, after it has once breathed, and received the air into the inmoft parts of the lungs, and by that means brought a new and large quantity of blood to that vif- cus, can fubfifl longer than a few minutes without the ufe and benefit of a free air ; but it will either perifh, or at lead fall into fuch a date as differs from death only in its being recoverable again by certain powers or aCfions. In an animal lately born, this necellity for air does not take place fo fuddenly. 276. But the ufe of refpiration is different from this neceffity j w'hich nature might have avoided, either by - ufmg Chap. IX; RESPIRATION; 129 ufing no lungs at all, or elfe by difpofing them in a man- ner refembling thofe of the fetus. This ufe, therefore, of refpiration muff be very conhderable, fince all ani- mals are either made with lungs, or with gills as in fifli, or elfe with a windpipe difperfcd through all parts of the body. 277. In order to difcover this ufefulnefs of refpira- tion, let us compare the blood of an adult perfon to that of a fetus, and alfo with the fame vital fluid in fifli. It appears then in a fetus, that the blood is defliitute of its florid rednefs and folid denfity ; and in the blood of fifli, we obferve, there is neither heat nor denfity, and but little craffamentuni contained in it| and, therefore, all thefe properties, we are, by the nature of things, perfuaded, the blood acquires in the lungs. 278. It may be afked therefore. Whether the blood does not acquire its heat principally in the lungs? But does not this arife from the alternate extenfion and con- traftion, relaxation and compreflion, of the pulmonary veflfels (265. and 272.), by which the folid parts of the blood are perpetually rubbed together, and clofely com- prefled and ground together? The lungs therefore wdlf add to the office of the reft of the arteries, becaufe in them the blood is alternately relaxed and comprefled more than in any other part of the body. But even when the lungs are obftrudted, ulcerated, and alnioft deftroyed, a morbid heat feizes upon the body : but in the lungs the cold air very nearly touches the blood. 279. The denfity of the blood is, indeed, again pro- moted in the lungs, partly by the copious difcharge of the watery vapour which is there feparated, by which the reft of the mafs becomes fpecifically heavier. But the fame efteft feems to follow here, as in other arte- ries, namely, from the attrition and preffure which the blood here fuffers in being alternately retarded, acce- lerated, and figured in its courfe through the modula- ting tubes of the leaft veffels, which give a fphericity and denfity to the particles ; hence it becomes denfer, as having more of the weighty globules, and lefs of the S lighter 130 RESPIRATION. Chap. IX. lighter fluid. And, in this refpecl:, the pulmonary vein, being fmaller than its correfponding artery, is ot no fmall ufe towards increafing the attraftion of cohefion betwixt the parts of the globules, fo as to comprefs and bring them clofer to each other. Neveithelefs, cold a- nimals, which have very fmall lungs, have denl'e and coa- gulable biood ; as alfo a chicken before it is hatched. The blood alfo has a fliort paflage through the lungs : through the whole body the palTage is longer, and the artery weaker; the heart, by which the blood is driven forward, is alfo weaker. 280. It is, therefore, queried by fome. Whether the air itf.lf is not received by the blood in the lungs, fo as to excite neceffary vibrations therein ? Whether this does nor appear from the refiftance of bodies to the heavy ex- ternal air ; and from the air found in the blood-veflels, in the cellular fubfrance, and in certain cavities of the human body ; alfo, from thecraking obfervedbyan ex- tenfion of the joints; to which add, the air manifcftly extravafated from the windpipes into the hearts of certain animals, as in the locuPc; from air coming out of the blood and humours of animals in Mr Boyle’s va- cuum; together with a neceiTity of a vital ofcillation in the blood itfelf; and, laftly, the increafed rednefs of the pulmonary blood ? 281. But that no elaflic air is here received into the blood, is demonftrated from the iinpoffibility of forcing air into blood, if it retains its eiaflicity ; from the inutili- ty of its reception, if the fpi ing of it fhbuld be lofl in the blood ; from the perfect immutability of the biood by cold; from the nhnutenefs of the inhaling velfels, with the mucus that perpetually lines the Tides of the veflcles in the lungs : to which add, the nature of the elaflic air itfelf, which is very unapt to pafs through capillary vef- fels ; with a repulfion of it by water, that hinders it from pafllng through paper, linen cloth, or fkins that are wetted by water. Again, the air being driven into the windpipe, never palfes to the heart; or whenever it does, it is forced thither by fome great or unnatural violence; Chap.IX. respiration. 131 violence : but the permanent air in the veffels and hu- mours of the human body, from a ftate of inelalficity, may become elaftic by putrefaftion, froft, or an exter- nal vacuum. But fuch permanent unelaftic air is in- t;orporated with all liquors ; and taken into our bodies with the aliments, and with abforbed. vapours, mixing flgwly and with fome difficulty. But there never were any elaftic bubbles of air obferved in the blood of a li- ving animal; and fuch air being inflated into the blood- veffels of any living animal, kills it certainly and fpeedi- ly. Nor is there any great certainty of the blood in the pulmonary veins being of a brighter red colour. Laft- ly, though air indeed is abforbed by moft of our hu- mours, yet that abforption is performed flowly, and takes up the fpace of feveral days after the former air has been exhaufted by the pump. It then likewife lays afide its elaftic nature ; nor is there any reafon produced why the air ftiould either be more fpeedily abforbed by the blood, or why it fhould retain its elafticity after it is fo abforbed. 282. Whether or not the blood is cooled in the lungs ; and whether or no this feems to be true from the death of animals in air which is hot to fuch a de- gree as equals the heat of the hotteft breezes in the moft fultry dog-days ? Whether the pulmonary veins are not, therefore, lefs than the arteries ; and whe- ther the defire of cold in people that are working hard does not arife from thence? That the blood is cooled in the lungs, is thus far true, in that it there warms the contiguous air, and therefore lofes fome- thing of its own heat. But that this was not the prin- cipal defign of nature here, upon the blood, is evi- dent ; fince no one will fay, that the venous blood is hotter than the arterial, although fome pronounce the former to be fomewhat cooler; but nobody ever obferved the left ventricle of the heart cooler than the right. Since, therefore, the venous blood enters the lungs; if it be there cold, it will follow, that the arte- ries muft receive it ftill colder. But then here the de- S 2 grees 132 RESPIRATION. Chap. IS. grees of heat, which the blood communicated to the air, are again recovered by it. And, indeed, a perfon may live in an air much hotter than the blood itfelf, of which we have a familiar example in baths, and the warm countries. The pulmonary artery in a fetus, which does not refpire, is greater ; and the larger area of the right auricle and ventricle of the heart is like- wife much greater in a fetus ; which feems neceffary to referve and retard the blood, as the pulmonary vein, being narrower, accelerates it. 2B3. Whether or not is the rednefs of the blood from the air ? This is contradided by what we fee in cold animals, which, though they are almoll entirely de- prived of the ufe of air, have blood equally red with that of warm animals ; from the certain connexion of rednefs in the blood of frogs with their having plenty of food, and a palenefs of it with a want of food ; and from the air, as we have juft now faid, being denied accefs to the blood. Neverthelefs, rednefs is produced when the air has accefs to the blood, by which means it is alfo reftored after it has been loft ; and, on the other hand, it is deftroyed by the denial of the accefs of air. Whe- ther or not may not a more fubtle element from the air penetrate the blood, and be the caufe of its colour, as light is required for the colours of plants ? 285. Whether the ufe of the lungs is to abforb a nitre from the air to the blood ? or whether the florid colour, obfervable in the furface of a cake of blood, be owing to the fame caufe, while the bottom part looks of a dark and blackiih colour? and whether or not this is a prefervative againft the putrefaftion of the animal? remain as queftions with foine. That tliere is a kind of volatile acid in the air is certain, fince that meeting with a fuitable earth forms nitre; for a nitrous earth, being exhaufted of its fait, and expofed again to the air, becomes re-impregnated with more nitre. But the fame univerfal acid, we know by certain experi- ments, meeting v/ith a different fort of earth, forms a vitriolic fait, or alum, or elfe fea-falt. For the caput mor-r Chap.IX, respiration. 133 mortuum of fea*falt, which remains after the diftillation of the fpirit, recovers fo much ftrength from the air, as enables it to yield more fpirit by diftillation ; even in fnow there is a cubical fait : but marcafite fweats out a true vitriol ; and colcothar recovers again the acid fpi- rit, which was drawn from it ; alfo fixed alkali, expofed to the air, turns into a vitriolated tartar. This, there- fore, cannot be the ufe of refpiration, becaufe thofe falts abound in too fmall a quantity in the air for fuch ufes; and air is fitteft for breathing when pure in high mountains, where thofe falts are the leaft to be found ; nor is there any nitrous fait as yet known to be found in our blood. 286. If it be afkedjWhy tortoifes, frogs, lizards, fnails, ear-wigs, and other infedls, live long without air? we anfwer, That in them the lungs are given not fo much for the preparation of the blood, which they receive but in a very fmall quantity, as for the ufe of fvvimming in the water: and from hence it is that their lungs are immediately joined with the venia cava and aorta. But infedts, we know, draw the air in, and exhale it again, through points in the fkin. If it be alked, why all a- nimals periffi in air that is confined or not renewed, although the animal be fmall, fuch as little birds? we anfwer, Becaufe the air, which has once entered the lungs, and been fouled by watery vapours, is rendered lefs elaftic, and unfit for refpiration, by alkaline vapours : not becaufe it becomes lighter ; for the mercury falls but little in air which has not been renewed, and which has killed an animal. Hence it is that the animal fur- vives longer in air that is more comprelTed than that of the atmofphere ; for in that cafe there is a greater proportion of the elaftic element, which takes up a longer time to corrupt it. But, even in other cafes, confined air is rendered deftruftive only by ffagnation, and filling it with vapours. But the reafon why animals fwell in an exhaufted veffel, is, from the extrication and expanfion of the unelaftic air lodged in the blood and other juices. 287. There 134 RESPIRATION. Chap. IX. 287. There is a certain confent or proportion be- tween the pulfe and refpi ration; fo that, according to the common courfe of nature, there are three or four pulfes counted to one refpiration. But if more blood is fent to the heart in a given time, the num- bers both of the pulfe and refpiration are increafed. This is the reafon of the panting or fhort breathing in a perfon that exercifes his body with any confiderable motion ; whereby the venous blood is returned fafter to the heart (142.) But if the blood meets with a greater refilfance in the lungs, fo that it cannot pafs frpely from the right into the left ventricle of the heart ; then the refpiration is increafed, both in the number and magnitude, to forward its courfe : and this is the caufe of fighing, yawning, and wheezing; of which the hrfl is a deep infpiration ; the fecond flow, and very great ; and the third, a frequent and imperfeft one. The number of refpirations, however, does not alwavs increafe with the pulfe; of which we have an example in thofe fevers where the lungs are not affeefed. 288. The mucus, which lines the fenfible mem- branes of the air-veffels in the lungs, may become troublefome both by its quantity and acrimony ; it has been even known to caufe fulfocation in a dropfy of the lungs. Therefore its quantity, adhefion, or acri- mony, excites a cough ; namely, an irritation of the refpirative fyftem, by alternate large infpirations, fuc- ceeded by large and quick exfpirations, together with fudden Ihocks of the abdominal mufcles ; by which the mucus, and fometimes calculous matters, are expelled from the lungs. 289. Laughter differs from coughing in its caufe, which refides commonly in the mind, or at lead con- fifts in a certain titillation of fome of the cutaneous nerves ; and, moreover, becaufe it is made up of im- perfedl quick exfpirations through the contracted glot- tis, left the air fhould be totally evacuated from the lungs. Hence laughter, in a moderate degree, con- duces to health ; becaufe, in the time of one full in- fpiration, Chap.IX. respiration. 155 fpiration, many fliort infpirations and exfplraticns hap* pen, and thus the concuffion is greater. Hence its dan- ger of Ifagnating the blood ; becaufe the exfpiration is not full or entire, whereby the blood is admitted into the pulmonary artery without being fufFered to pafs through it. Weeping begins with a great infpiration, after which follow Ihort alternate infpirations and ex- fpirations ; and the fame is finiflied with a deep exfpira- tion, that is immediately joined by a large infpiration : hence it has nearly the fame good and bad effects ; and, when moderate, it conduces to relieve the anguifli ari- fing from grief. An hickup is a very great, fonorous, and fudden infpiration. Sneezing confifts of one large or deep infpiration, which is followed immediately with a powerful and fudden exfpiration ; and the acrid mat- ter is blown out by it in fome quantity from the no- ftrils. 290. The additional or fecondary ufes of refpiration are very many. It exhales, as an emunftory, parts re- dundant, or even noxious, from the blood, which would fuffocate if they remained in the air ; and the breath of many people fhut up in a clofe place, impregnates the air with a fuffocating quality. On the other hand, it abforbs from the air a thin vapour, of which the ufe is perhaps not fufficiently known. It is by this force that the abdomen and all its vifeera are continually com- preffed ; by virtue of this, the ftomach, inteflines, gall- bladder, receptacle of the chyle, bladder of urine, intef- tinum redtum, and the womb itfelf, difeharge their contents ; by this adfion the aliments are principally ground or diffolved, and the blood is urged through the fluggifh veffels of the liver, fpieen, and mefentery. It excites a kind of flux and reflux in the blood, fo that it is alternately preffed back towards the extremities of the veins, and a little after is propelled towards the heart by an accelerated velocity, as into an empty fpace. Moreover, infpiration ferves to convey odours with the air to the organs of fmelling. Bv this, the air is mixed with the aliments j which it conduces very much to break 136 VOICE AND SPEECH. Chap.XL break and diffolve towards a perfect dlgeftion. But even fucking, fo neceflary to the new-born infant, is made by the ufe of refpiration, and forming a larger • fpace in the mouth, in which the air is rarefied ; fo that, by the greater preffure of the outward air, the milk is driven into that part where it is lefs refified. Laftly, the voice itfelf is owing to the air winch we breatlie ; therefore it may not be inconvenient for us, in this place, to defcribe it more particularly. CHAP. XI. Of the Voice and Speech. 291.^ I "^HE principal organ of the voice is the larynx ; JL for, that being injured, the air palfes through the windpipe without yielding any found. By the la- rynx, we underhand an affeinblage of cartilages, joined into a hollow machine, which receives the air from the fauces, and tranfniits it into the windpipe, having its parts connedted together by ligaments an(^ mufcular fibres. Among thefe cartilages of the larger kind, thofe called the annular and fcutiform are, in adults, frequently changed into bone. The anterior and lar- ger part of this larynx, which lies almoft immediately next to the fkin, is compofed of two cartilages; one cal- led tbyreoides, the other cricoides ; to which laft, the la- teral parts of the larynx arc fo joined, that the portions of the cricoide cartilage are always fo much larger as they are higher feated. The back part of the larynx is firfi; made up by the faid annular cartilage, after con- nefted by the arytgenoide mufcles. The epiglottis is loofely connedled above the larynx with the thyreoide cartilage, in fuch a manner, that it may be able to rife up and fhut down. The blood-veffels of this part are from the upper thyreoids ; and the nerves, below, are numerous from the recurrents ; as above, alfo, there are nerves coming from the eighth pair varioufly inofcu- lating i CuAP.Xt. VOICE AND SPEECH. 137 lating ; fome alfo from the intercoftal. The former of thefe nerves is remarkably famous for its arifmg in the thorax, and being afterwards inflefted round the aorta and right fubclavian ; and for the origin which it gives to fome of the nerves of the heart, as well as for the experiment by which a ligature upon the recurrent is found to deftroy the voice. 292. All thefe cartilages are connefted together by various mufcles and ligaments, with a certain degree of firmnefs, to the adjacent parts ; and yet fo that the whole is eafily moveable together, as are alfo its feveral parts upon each other. Particularly the fcuUform car- tilage, or the thyroidea anterior, is compofed of two plates, which are almofl; quadrangular, and inclined to each other in an obtufe angle, which is foremofl. Up- on thefe cartilaginous plates are fometimes found two apertures, one on each fide for the blood-velfcls of the larynx ; but are not very often to be obferved. The upper proceffes of this cartilage, terminating without any protuberance, are inclined upward and backward, to their connexion with the horns of the os hyoidcs, by flrong ligapients, fometimes mixed with bone. The lower parts of thefe cartilages are fhorter, and adapted almofl with a flat furface to thofe of the cricoide carti- lage ; to which they are connected with a very firm ar- ticulation, by a flrong and fhort cellular fubflance, u- niting them on each fide. The middle parts before, being perforated with flrong ligaments, are connected by the infertion of them to the middle of the annular cartilage ; and likewife by other ligaments above, de- feending from the horn of the feutiform cartilage into the upper part of the annular cartilage. 293. The croicoide cartilage is before thick, and flrong: it is increafed backwards, in form of a ring un- equally truncated or cut through ; and, in its middle part, is divided into two cavities by a protuberant line. This is firmer than the reft of the cartilages, and, in a manner, the foundation of them : from this there are longitudi- nal mufcular fibres and ligaments, which defeend into T the 138 VOICE AND SPEECH. Chap.XE the windpipe (238.) The pharynx likewife is con- nected to the furface of thefe cartilages by many muf- cular plates, and receives the larynx as it were into its bag. From this a (hort ligament comes in both Tides to the arytasnoide cartilage. 294. The two arytaenoide cartilages are of a very complex figure, fpontaneoufly dividing into two parts. Of thefe the lower is larger ; and is connected by a moveable junCture with the protuberant cricoide carti- lage, by a bafis moderately hollow j and the fame fends forth a procefs forwards, which feparates the glottis, and fuflains the inferior part of the ventricle of the larynx. They afeend upwards, of a triangular figure, with the polterior angle hollow, the anterior convex, divided by three furrows or fulci, and extenuated upwards, till they are at laft finiflied or terminated by a pretty thick, oval, cartilaginous head fixed on them. The lower part of thefe cartilages is connected by numerous mufcular fibres, partly tranfverfe, and partly oblique ; of which the different directions are vifible enough, but the fepa- ration of them impracticable. Thefe are called arytte- noide mufcles. In the upper part, the arytaenoide car- tilage departs from its companion or fellow cartilage, leaving a cleft perpendicularly betwixt them, which has been (not very properly) by fome called the glottis. 295. The arytaenoide cartilage is connected with the thyreoideal by tranfverfe ligaments, fufficiently ftrong and elaflic, but covered with the common mucous membrane of the larynx, wdiich ligaments are inferted into the flat angle of the thyreoid cartilage (292.) Thefe ligaments may be drawn out or ftretched from each other, by removing the contaCt of their arytae- noide cartilages, and may be again conjoined together by placing the cartilages one to another : and this is the true glottis, which is continuous, but at a right angle with the above-mentioned cleft (294.) 296. From the fame angle of the thyreoid cartilage, under a notch, from a firm ligament, and an ereCl flender ftalk, is extended an oval cartilage, in its fore- part Chap.XI. voice and speech. 139 part convex, behind concave, and railed up in fuch a manner, by its elafticity, as to project confiderably behind the tongue ; but is fo flexible or inclinable down- ward, whenever the root of the tongue is prelTed back- ward, that, by its tranfverfe pofition, it fiiuts up all paflTage into the larynx, and defends it in fuch a man- ner, that whatever is contained betwixt this part, called the epiglottis, and the arytsenoide cartilages, palfes over downward into the pharynx. The epiglottis is con- joined to the tongue by pale membranous fibres, and to the os hyoides it is connedted by many membra- nous expanfions. But as for mufcular fibres from the thyreo-arytsenoidal and arytasnoidal mufcles, it has ei- ther none at all, or elfe fuch as are too minute to have any effect upon its elafticity. 297. By the fides of the ligaments of the glottis (295.), there are two other upper and fofter liga- ments, which go out parallel from the arytsenoide cartilage to the fcutiform one, which ligaments are fomewhat lefs tendinous and lefs claflic. Betwixt thefe two ligaments, on each fide (295.), a peculiar ca- vity or ventricle defcends, having the figure of a com- preffed parabolic finus extended downward betwixt the doable membrane of the larynx, opening con- flantly with an elliptical mouth by the fide of the glot- tis in the larynx. 298. Laftly, all the internal cavity of the larynx is lined with the fame foft, fenfible, or irritable and mu- cous membrane, as we before defcribed in the wind- pipe (239.) But this membrane is watered by a great number of fmall glands. The uppermofl are fmall fimple glands, affembled together in a heap (208.), feated on the anterior and convex part- of the epiglottis, upon the hollow furface of which they fend out various openings, large finufes, and produftions ; and others are, in like manner, continued there in fmall hard kernels. Moreover, upon the hollow anterior furface and back of the arytsenoide cartilages (294.), there are fmall glandules placed on each fide of a loofe conglo- T ? merate 140 VOICE AND SPEECH. Chap. X. merate fabric, compofed of little round kernels, doubt- lefs muciferous, having fome of their loofer parts ex- tended on each fide as low as the annular cartilage. In the cavity of the ventricles, there are very many mu- cous finufes. Laftly, all the internal furface of the la- rynx is full of large mucous pores. All thefe glan- dules feparate a thin watery mucus, which yet has a confiderable degree of vifcidity. 299. It may be afked, If the thyreoide glandule has a like ufe, and is of the conglomerate kind, but foft and lobular, with many coverings, confiderably large or broad in its extent, but of a more tender fub- flance than the falival glands, feated upon the thy- reoide cartilage, and in part upon the cricoide carti- lage and windpipe, along their fore-part, fo as to in- compafs the lateral horns and Tides of the thyreoides, joined to its companion, which is narrower, by an ifthmus, which is emarginated on the lower part, but afcending upwards by a very thin procefs before, in its middle part, as far as the os hyoides ? This gland is full of a fcrous, yellowifii, and fomewhat vifcid hu- mour : but whether it emits the fame into the wind- pipe or into the cefophagus, is a queftion ; at lead; there are no dufts certainly known to open into either of them. Whether or not the juices are altogether re- tained in this gland, and afterwards poured into the veins in a manner refembling the fabric of the thy- mus, or whether it is of the conglobate kind, is uncer- tain. Yet that the ufe of this gland is very confider- able, may appear from the largenefs of the arteries ■which it receives from the carotids and lower fubcla- vians. The veins thereof return their blood into the jugulars and fubclavians. It has a peculiar mufcle, not conftantly to be found, arifing from the edge of the os hyoides, and fometimes from the lower margin to the left of the thyreoide cartilage, which defcends without a fellow, fpreading its tendinous fibres over the gland. Upon which alfo the llernohyoidei and flerno- Chap. XI. VOICE and SPEECH. fternothyreodei mufcles are likewife fpread or incum- bent, 300. The whole larynx is fufpended from the os hy- oides by the ligaments proceeding towards the fuperior horns of the thyreoide cartilage, and perfefting that car- tilage from the middle of its bafis to the conjunction of its plates. The fame, together with the conjoined os hyoides, is capable of being raifed confiderably, at leaft half an inch above its mean altitude. This is performed by the biventer mufcles, together with the geniohyoidei, geniogloffi, ftylogloffi, ftylohyoidei, flylopharyngei, thy- reopalatini, hyothyreoidei ; all or fome of which con- fpire together in that a6tion. In this elevation the glot- tis is prelfed together or made narrower, and the liga- ments beforementioned (295.) approach nearer toge- ther. But thus, by the affiflance of the adlion of the arytaenoide mufcles, together with the oblique and tranf- verfe ones, the glottis may be accurately clofcd, fo as refill with an incredible force the prelTure of the whole atmofphere. 301. The fame larynx may be, in like manner, de- prelfed to about half an inch beneath its ordinary fitua- tion, by the flernohyoidei, llernothyreoidei, and cora- cohyoidei, as they are called; and, when thefe are in a£tion, alfo by the joint force of the anterior and polle- rior cricothyreoidei. In this motion the arytaenoide car- tilages depart from each other, and render the glottis wider, which is alfo drawn open laterally by the muf- cles inferted into the Tides of the arytaenoide cartilages, together with the crico-arytaenoidei poftici and laterales, and thyreo-arytaenoidei : thefe may alfo compreTs the ventricles of the larynx (297.) on which they are incum- bent; the particular cartilages which make up the la- rynx can fcarce be moved feparately. 302. From the larynx the air comes into the mouth and noflrils. By the mouth, we mean that large and irregularly lhaped cavity between the foft and hard pa- late, both concave in the middle, and lower down parted between the mufcles which lie under, and the lower jaw. 142 VOICE AND SPEECH. Chap. XL jaw. The noltrils afcend forv/ards above the foft pa- late; they are two broad cavities intercepted between the feptum medium, the offa cavernofa, and various o- ther bones. They are every where bony and cartilagi- nous. 303. The tongue lies in the middle of the mouth; and is a broad piece of flelli eafily changeable into any kind of figure, and thus readily moved without delay to every part of the mouth; molt expeditioufly directed into every fituation, and made to affume any fhape, by its own flefhy fibres, and by the mufcles attached either to itfelf or to the os hyoides w'hich is joined to it by many flefiiy fibres and membranes. In the fore-part thefe come from the genioglofii and geniohyoidei muf- cles ; backwards from the ft) loglofii, ftylohyoidei, cera- togloffi, bafioglofii, chondroglofii, and biventer; down- wards, from the llernohyoidei and ceratohyoidei ; up- wards, from the ftyloglofil, ftylohyoidei, from the bi- venters, and likewife from the mylohycidei. 304. Hitherto we have given the anatomy. It re- mains, therefore, that w’C demonftrate what action the air produces wdien it is driven by the forefaid powers (269, 270.) from the lungs in exfpiration through the windpipe into the larynx, and from them urged out through the glottis into the mouth varioufty configured. The confequences or effedls of this are, voice, fpeech, and finging. The voice, indeed, is only formed, when the air is expelled with fo great a velocity through the contrafted glottis, that it fplits or makes a coHifion up- on the glottid ligaments, fo as to put the larynx into a tremor, which tremor is returned and continued or in- creafed by the elafticitv of thefe parts. Sound, there- fore, arifes from the conjunct trembling of the liga- ments (295-) together with the cartilages of the larynx at one and the fame time, which we then call the voice, and is of a peculiar kind or modulation in every fingle clafs of animals, depending entirely upon the difference of the larynx and glottis. But when a trembling is not excited, the exfpired air caufes a whifper. 305. The Chap. XL VOICE and SPEECH. 143 305. The ftrength of the voice is proportionable to the quantity of air blown out, together with the narrow- nefs of the glottis; and, therefore, a large pair of lungs eafily dilatable, with an ample cartilaginous and elaflic larynx and windpipe, and the free echo of the nollrils, joined with a powerful exfpiration, all conduce to this cffeft. But acute and grave tones of the voice, we ob- ferve to arife from various caufes. The former proceeds from a tenfion and narrownefs of the glottis, and the latter from a relaxation and expanfion of it. For thus, in the former, a greater number of air-waves are fplin in the fame time upon the ligaments of the glottis, whence the tremors excited at the fame time are more numerous; 'but when the glottis is dilated, the con- trary of all this follows. And from the greater tenfion of the ligaments, the tremors in like manner become more numerous from the fame llroke. Therefore, to produce an acu*«: and Ihrill voice, the whole larynx is drawn upwards and forwards ; and fo much the more as the voice is required to be fharper, infomuch that the head itfelf is inclined backwards, by which the powers of the mufcles elevating the larynx are rendered more full and effeftual. The truth of this is confirmed by experience, by applying the fingers to the larynx when it forms an acute found; for then, to raife the voice an oftave, you will eafily perceive it to afeend near half an inch. Alfo the fame is evident from comparative ana- tomy, which demonftrates the narrowed glottis and the clofefl; approximation of cartilages in finging birds, but an ample or broad glottis in hoarfe animals and fuch as bellow or bleat. An inftance of this we have in whiff- ling, where the voice manifeffly becomes more acute by a contradlion or narrownefs at the mouth : alfo in mufical inftruments, in which a narrowmefs of the mouth or opening that expels the air, with a celerity of the wind blown out, are the caufes of an acute or fhrill tone. 306. Gravity of the voice, on the contrary, follows from a depreffion of the larynx by the caufes (301.) al- ready 144 VOICE AND SPEECH. Chap. XI. ready defcribed ; to which add a broad glottis and a very ample larynx. This is evident to the touch of the finger applied to the larynx when a perfon lings, by which the defcent of it is inanifeftly perceived to be a- bout an inch for every oftave ; hence the voice of males is more grave; and hence the loweft degrees of the voice degenerate into a mutenefs or whifpering. 307. Is the whole difference of tone owing to the length of the ligaments of the glottis, which is aug- mented when the feutiform cartilage is drawn forward, and the arytsnoide ones backward ? Is it according to this rule, that the moll acute tones are produced, which arife from the ligaments being exceedingly ftretched, and thus vibrating with great celerity ? This has been confirmed by repeated experiments made by eminent men ; and fome late anatomifts have obferved, that, when the chords or ligaments of the glottis are tenfe, the peculiar voice of every kind of animal is produced by blowing air into its larynx: that this voice was more acute as the ligaments were more tenfe, and more grave as they were llackened : that by fhutting the whole ligament, the voice was fuppreffed ; by lliutting the half, the voice was rendered an o£tave higher ; by Ihutting a third part, a fifth higher, &c. There are not wanting, however, doubts concerning this new theory, arifmg from the cartilaginous and bony firuefure of the glottis of birds, which of confequence mult be im- moveable, and not extenfible ; from the voice moll cer- tainly becoming more acute, in whittling, from the mere contraftion of the lips ; from the example of women, in which the larynx is fofter, but the voice more acute, than in men ; from experiments which Ihow, that more acute founds are produced by bringing the ligaments of the glottis nearer into contact with each other; from the perfect want of machines, by w'hich the ligaments can be Itretched, and which may bring the feutiform cartilage forward from the annular one. But feeing it appears from experiments, that a tenfion of the liga- ments fuffices for producing acute founds, without the con- Chap.X. voice and speech. ,145 contraftion of the glottis, we may believe that the dif- ferent tenfion of the glottis contributes more to the di- verfity of voice than the different diameter of it. 308. Singing is when the voice, modulated through various degrees of acutencfs and gravity, is expelled through the larynx, while it is trembling and fufpeuded betwixt two contrary powers ; and herein lies the prin- cipal difference betwixt the chanting of fimple notes, and the expreffion of words. Hence it appears to be a laborious aftion, by reafon of the continual contrac- tions of the mufcles, which keep the larynx at an equi- librium; and hence it is, that finging makes a perfon hot ; becaufe in acute tones the narrow^er glottis much retards the exfpiration, while at the fame time a great deal of air is required to give ftrength to the voice (305.); towards which, again, deep infpirations arene- ceffary. Hence likewife the windpipe is rendered very dry,fiom the quicker paffage or current of air: to pre- vent w'hich, a great deal of mucus is required ; and therefore it is that there are fuch numbers of mucous receptacles in the larynx, amongft which I am firmly of opinion the ventricles before defcribed (297.) ought to be numbered. 309. Speech is performed by the larynx at refl, or held in the fame place, in tones of voice differing but little in acutenefs and gravity ; but then the voice is varioufly changed or modulated by the organs of the mouth. Canorous fpeech has a variation in the tone or cadence of the voice, together with a modulation of it by the organs of the mouth at the fame time. 310. All fpeech is reducible to the pronunciation of letters, which differ in various nations ; but mofl of them are alike all the world over. Of thefe, fome are called vowels, which are made only by an expreffion of the voice through the mouth, without any application of the tongue to certain parts of the mouth. But con- fonants are formed by a coHifion of the tongue againfl certain parts of the mouth, lips, and teeth. But to be more particular in thd’e matters is befide our purpofe, U which 14<» BRAIN AND NERVES. Chap. XI. which will not permit us to expatiate upon the beautiful art of pronunciation. That art, as an extraordinary in- ftance of mechanical knowledge, has fo accurately de- termined all the corporeal caufes concurring to each letter, that, by infpeflion only, with the affidance of touch, letters pronounced are underflood without hear- ing them, and the attentive perfon is thereby taught to imitate the fame fpeech by a like ufe of the organs. CHAP. XI. Of the Brain and Nerves. gii.np'HE remaining adions of the human body X we fhall confider according to the order by which they receive the blood. The coronary arteries we fpoke of before, when we gave the hiflory of the heart. Next to thofe, the carotids pafs out from the aorta. 312. The aorta, which comes out from the anterior part of the heart (i57.)5 in order to bend itfelf tow'ards the vertebrae of the thorax, forms there a confiderable arch, by which it is bent backward, and towards the left, in an angle that is round, but not very large. From the convexity of this arch, three confiderable branches arife. The firfl afeends tow'ards the right fide, and is immediately fnbdivided into tw'o large ar- teries, of which the lowermoft goes on in the diredion of its trunk, under the denomination of the Jubclarc'ian. The other afeends according to the courfe of the wind- pipe to the head, and is called the right carotid. The left carotid fprings next from the fame arch, a little in- clined to the left fide ; and the third, w'hich is flill more inclined to that fide, is called the left fubclavian, which is fomething lefs than the right. About the origina- tion of thefe arteries, the next continuous margin of the aorta is a little thicker and more protuberant. But va- riations fronithis courfe are rarely obferved. 313. The Chap. XI. BRAIN and NERVES. 147 513. The carotid artery, furrounded with a great deal of denfe cellulofity, together with the jugular vein and nerve of the eighth pair, commonly afcends as high as the upper part of the thyreoide cartilage, with- out fending off any branches. There it divides into two trunks. The anterior, called the carotid, which is rather larger and more in the diredfion of its trunk, fends off a branch called the fuperior thyreoidea, alfo the infledled arteria lingualis, and then the labialis; and from the poflerior face of the carotid, the next ar- tery which arifes is the pharyngea afcendens, which, befides the pharynx and mufcles of the moveable palate, fends likewife a confiderable branch in common with the nerve of the eighth pair through the foramen of the jugular vein to the dura mater, very near to the great foramen of the occiput, at the bafis of the os petrofum, and which is divided at the cuneiform procefs of the multiform bone. 314. Again, from the edge of the external carotid, fprings the occipital artery ; which fends branches not only to the mufcles which give it a name, but like- wife fends a branch through a peculiar foramen of the dura mater in the angle which the os petrofum forms by departing from the mamillary procefs, which artery is fpread through the feat of the cerebellum ; another branch palfes over the atlas to the dura mater under or into the Ikull ; and a third fometimes goes through the foffajugularis to the dura mater. The next artery, which is the auricularis, goes to the back part of the ear, to the temple, and to the membrane of the tympanum. 315. What remains of the external carotid artery, afcends through the parotid gland, to which having given fome branches, as well as to the face and eye*lids, it fends out the temporalis, which is confiderable. The trunk of the carotid, being inclined, conceals itfelf be- hind the lower jaw, under the denomination of maxiU laris interna. 316. In that place, it direftly fends off a large trunk, which pafles to the dura mater through a peculiar open- TJ 2 ing 245 BRAIN AND NERVES. Chap. XT. ing of the broad and pterygoide wings, feated at the middle fofla of the brain ; from whence they are large- ly fpread through the temple’s and forehead within the dura mater, as far as the falciform finus. Sometimes this artery is double, and often gives out a branch that is confpicuous to the lachrymal gland of the eye. In the fame place, likewife, the maxillary artery enters the upper part of the nares, by a threefold trunk, where it is fpent, after having given off the branches call- ed maxi Hares inferior and fuperior to the teeth, with the infra orbitalis to part of the face and eye-lids, and the palatina to the bone of the palate, with fmall branches to the dura mater, and others through the fmaller pores of the great wings, with fuch as accom- pany the third and fecond branch of the fifth pair of nerves ; and laftly, together with the dura mater, hiling up the lower orbital fiffure. 316. But the other pofterior trunk, commonly cal- led the internal carotid (31 3-)» ^feends without a branch. This artery, having firft made a confiderable ferpentine flexure, enters through a peculiar foramen in the os petrofum, where it is furrounded with a capfule from the dura mater, like that which comes out through all the openings of the fkull : from thence it afeends up- wards and inclined forwards, till, having penetrated in- to the cavity of the fkull, it rifes up inflected and in a curvature, according to the dlreftion of the fella equi- na, in the middle of which there is a cavernous or hol- low finus retarding the blood : from thence, having given fmall branches to the fifth pair of nerves, it fends others to the infundibulum and dura mater, with one larger to the eye ; part whereof returns again through a peculiar hole into the dura mater, which lies upon the middle of the orbit. This is the rete inirabilc of beafts, but not of man. 317. But the trunk of this internal carotid palTes o- ver the anterior part of the fella equina ; and being in- curvated backward, and received by the arachnoide membrane, giving branches to the pons and crura of the brain, Chap. XL BRAIN and NERVES. 149 brain, with a circle to the choroide plexus, and one tha^ accompanies the optic nerve, it then divides into an an- terior and pofterior branch. The former, being con- joined with its fellow artery of the other fade by a diort inofculating branch, which foraetimes fprings from the trunk itfelf, is then incurvated backward and upward, according to the diredtion of the os cailofum, and fpreads itfelf about the middle and hinder part of the brain ; where it fometimes fends branches to the falciform procefs, and from the very origin of the third ventricle to the fornix and thalami. Tlie latter, being conjoined by a fmall inofculating branch with the ver- tebral artery, unit Is that arifes from the undivided trunk of the carotid artery, afterwards afcends a long way up- on the fide of the brain through the Sylvian fofl'a ; and the fame fends branches to the choroide plexus. All the branches of the carotid, contained witfiin the fkull, are made up of more thin, folid, and britde membranes, than the other arteries of the body. 31 8. But the vertebral artery^ commonly ai'ifing from the fubclavian of the fame fide, (though the left has been fometimes feen to fpring from the trunk of the aorta,) palfes on without giving branches, through a place of fecurity, till it enters a foramen in the tranf- verfe procefs of the fixth vertebra of the neck; after which, it continues with alternate flexures to afcend through the oblique proceffes of the other vertebrae of the neck ; from whence, at each interval, it fends off fmaller branches to the mufcles of the neck, and com- municates with the lower thyreoideal : other branches, again, -fomewhat larger, go from it backward, together with each of the nerves, to the pia mater of the fpinal medulla; but before, the branches are larger, though lefs numerous, to the fame fpinal medulla, and commu- nicate by an anaffomofis with its fpinal artery anterior- ly. Laflly, growing lefs about the fecond vertebra, and being inflecfed with a large curvature round the tranf- verfc procefs of the firft vertebra, it there fends off con- fiderable branches to two of the mufcles of the neck : alfo 150 BRAIN AND NERVES. Chap. XI, alfo fmall branches it fends off in its courfe through the great foramen of the occiput or ikull to the dura mater, and the adjacent cavities that contain the cerebellum j after which, it goes on through the faid foramen into the cavity of the fkull. There afeending, according to the courfe of the medulla oblongata, the right trunk by degrees approaches nearer to the left, and is conjoined together with it (in an extraordinary manner, hardly to be found in other parts) into an artery called the baftli- aris, which is fufpended in the pia mater all along under the pons Varolii. From the vertebral arteries, before they are conjoined together, or from the trunk produ- ced after the common manner, pafs out branches, which go to the lower furface of the cerebellum, and are deep- ly inferted under the fourth ventricle to the inner fub- flance of the cerebellum. Thefe fend off the fpinal ar- teries. But there are fome inftances where they arife conjunclly from a fingle trunk ; or from the trunk in one fide, and a branch in the other. Then the bafifia- ris, befides branches to the medulla oblongata and crura of the brain, gives the other lower arteries of the cerebellum. Amongfl the forefaid branches alfo arifes an artery, which accompanies the auditory nerve. Finally, the bafiliaris, at the forepart of the pons, di- vides into two branches. One of thefe goes to the up- per part of the cerebellum, to the fourth ventricle, to the crura of the medulla of the cerebellum, the nates, teffes, and pineal gland ; in place of this, alfo, there are two trunks. The other is divided to the lowelt part of the brain at its poflerior lobe, the choroide plexus, the plexus incumbent on the pineal gland, that gland itfelf, the thalami, corpora ftriata, fornix, and whole anterior ventricle of the brain. 1519. From the foregoing hiftory of the arteries be- longing to the brain, it appears, that a very great quan- tity of blood is in every pulfation lent to this organ, in- fomuch that it makes above a fixth part of the whole blood that goes throughout the body, and derived from trunks that are very near the heart, fpringing from the con- Chap.XI. brain and NERVES. 151 convexity of the aorta. From hence it is probable, that the ftrongefl parts of the blood go to the head, and fuch as are mod retentive of inotion. Is not this evi- dent from the effefts of mercurials exerting thenifelves almoft in the head only ; from thefuddcn force and aflion of inebriating fpirits upon the head ; from the ll';at joins the tentorium : it is generally inclined to the right fide, and takes the name of the right tranfuerfe fuius^ which then goes by a peculiar channel in the occipital and tempo- ral bone, tranfverfely to its incurvation at the opening of the jugular vein; in which place being much enlar- ged, it receives the lower finus petrofus, together with the occipital ones, which are hereby difeharged into the jugular vein. But the left tranfverfe finus refeinbles the former; and is, like that, conveyed in a fimilar courfe to the jugular vein, into which it is rather infert- ted on the right fide, than continued as it were in a trunk. Into it the fourth finus (325.), together Miih the occipital one, ufually infert thcmfelvcs. But there are fome inftances, where all thefe are difpofed in a dif- ferent manner, by an infertion of the longitudinal into the left tranfverfe finus ; and then the right tranfverfe iinus receives the fourth and the occipital one. At o- ther times it is equally divided into two tranfi’erfe trunks; and fometimes the middle finus joins the tranf- verfe ones. The two finufes alfo have been found fi- milar and parallel to each other. 327. There is a flender and rounder finus, which runs along the lower and thicker margin of the falx, fomewhat of an irregular figure, more refeinbling a vein, receiving veins from the falx itfelf, and conmiu- jiicating likewife with the upper finus ; it alio receives veins from the adjacent hfemifpheres of the brain, and from the corpus callofum. Where the tentorium joins with the fore-part of the falx, this is commonly there inferred into the fourth finus. 328. lower veins of the brain, which lie next to the bafis of the fkull, are varioufly inferred. Ihe foreniofl of them coming from the foifa fvlviana, col- let^cd Chap.XI. brain and NERVES. 157 kcled together into fome trunks, are inferted into th'e cavernous finus, or triangular interval, that lies at the fide of the fella equina, betwixt the external and inter- nal plate of the dura mater. Other veins, from the pons itfelf, lead into the upper finus petrofus. O- ther pofterior veins, which come from the pofterior lobes of the brain, are inferted in great numbers in- to the tranfverfe fmus that is feated within the tento- rium. 22 9. The upper veins of the cerebellum, meeting to- gether in large trunks, partly open themfelves into the fourth finus, and in part into the tranfverfe finus. The fewer veins, from the cerebellum and medulla oblonga- ta, infert themfelves into the upper fmus petrofus ; the latter alfo into the tranfverfe procefs very near the place where it goes out. J530. There are rnany finufes, befides thofe before- mentioned. The mod anterior of them, which is com- monly like a circle, is larger behind than in its fore-part, w^hich is flenderer, and furrounds the pituitary glan- dule betwixt theclinoide proceffes, communicating with the cavernous and with the lower petrofe finufes ; like- wife communicating betwixt thofe proceffes and the ca- rotid artery, and again, by the way of the fixth pair, with the upper petrofe finufes behind the fifth nerve. There are fome inftances where this fmus receives the ophthalmic vein ; and fometimes the tranfverfe, joining to the cavernous finus, fupplies the place of this circular fmus, or elfe is prefent with it at the fame time. 33 T. Tht upper petrofe finus \s conveyed backwards in a cavity of the os petrofum, and takes its origin from the extremity of the anterior fulcus of the os petrofum, where it communicates with the cavernous finus, and receives the infertions of the veins of the dura mater, and fometimes of the anterior veins of the brain itfelf, mentioned before (328.); then it is inferted into the angle of the tranfverfe fmus, where it begins to be bent j fometimes alio it joins the inferior fmus of the pe- 158 BRAIN AND NERVES. Chap. XI. os petrofum. Another vein, likewife defcending by the os petrofum, is in like manner inferted into the angle of the tranfverfe finus. The lower firms pe- trofus, which is larger, goes round the root of the bone of this name, and communicates with its fellow behind the clinoide procefs ; alfo twice it communicates with the cavernous finus, and with the upper fmus, and is conjoined under the nerve of the fifth pair, being finally inferted into the jugular foffa or cavity. Moreover, it receives fome veins of the dura mater from the bafis of the vertebras. To the fame outlet alfo the occipital fmus leads on each fide, which being pretty large, goes round the margin of the foramen, till, arriving at the falx of the cerebellum (g2i.), it is fooner or later inferted, together with its fellow, for the moft part into the fourth fmus, and with that into the left tranfverfe one, or into the longitudinal finus it- felf, or .laflly by a divided extremity into each of the tranfverfe finufcs. This finus receives the lower and pofterior veins of the dura mater, and fome others from the vertebras. 332. The anterior occipital fmus is irregular or mul- tiform, partly tranfverfe, and partly defcending to the great foramen, being varioufly conjoined with the lower petrofe finufes: from whence it pafi'cs with the nerves of the ninth pair; and either communicates, through a peculiar foramen, by emiffaries into die outer vertebral vein; or other branches, paffing out below, open into the venous circles of the fpinal medulla. But the ca- vernous fmus of the dura mater (325.), being furround- ed with a good deal of cellular fubftance, receives, be- fides the forementioned finus (329, 330.), large veins already deferibed ; alfo the ophthalmic, and principal vein of the dura mater ; and tranfmits them with pecu- liar veins, together with the fii ft and fecond nerve, and third branch of the fifth pair, with a large artery of the dura mater (316.) and the internal carotid (316.^ : al- fo it fends out other emiffaries through a foramen, ■which is not conftant in the great wing, which fo;m Chap.XI. brain and nerves. 15a inofculations with veins placed on the outfide of the Ikull leading to the jugulars, and efpecially with the largeft pterygoidal plexus of veins belonging to the nofe. in the fame manner, the veins of the pericra- nium pafs through fmall holes in the parietal bones into the longitudinal fmus, as the occipital veins pafs thro’ the malioide hole into the tranfverfe fmus through the anterior channel of the occipital bone, and the external vertebral veins are inferted into the jugular fmus ; and others of the anterior occipital veins accompany the nerve of the ninth pair. Thus there are an infinite number of ways open to the blood ; by which it may pafs from the fmufes, wherein it is often colleded in too great quantity, by various direftions, according as the part is more lax, or has a greater declivity. Hence no violent fymptoms follow upon tying either or both of the jugulars or other large veins. 533. The great quantity of blood which goes to the brain, the greater impulfe with which it is fent into the carotid arteries (3i9.)» the immunity of this part from every kind of preflure by a ftrong bony fence, joined with the flower motion of the blood through the abdominal vifeera and lower extremities, alfo the perpe- tual exercife of the brain and fenfes, do all determine a copious flux of blood to thefe parts, and fome other caufes ferve to fill the head furprifingly with blood. Hence it is that a rednefs of the face, a turgefcence and fparklrng of the eyes, with a pain and pulfation or throbbing of the arteries in the head, are fo frequently followed with a bleeding at the nofe, by violent exercifes or motions of the body. From hence, therefore, it is evident, that, if the veins were of a thin and round flrudure in the brain, they would be unavoidably in greater danger of breaking, whereby apoplexies (to which, in their prefent ftate, they are often liable) would be much more frequent. To avoid this, therefore, nature has given a different figure to the veins which carry out the blood from the brain, by which they are more eafily -and largely dilatable, becaufe they make an unequal re- fiflance ; i 6 o BRAIN AND NERVES. Chap. XT. fiftance ; their texture is likewife very firm, and more difficultly broken, efpecially in the larger finufes, which perform the office of trunks ; for as to the finufes of the leffier fort, they are either round, half cylindrical, or of an irregular figure. Befides this, nature has guarded the finufes by crofs-beams, internally made of ftrong membranes, and detached from the right to the left fide within the finus, which, in greater dillenticns, they draw towards a more acute angle, which is ca- pable of a larger dilatation, flrengthening and guarding it from a rupture at the fame time. She has likewife, in thefe veins, provided numberleis inofculaticns,by which they open mutually one into another, and openly com- municate with the external veffels of the head and with thofe of the fpinal medulla, by which means they are capable of freeing themfelves more eafily whenever they are overcharged with blood, ^52.) 334. It is by fome queried. Whether a part of the arterial blood is not poured into the finufes of the brain ; and whether they have not a pulfation excited from that blood ? That they have no pulfation, is pafl doubt ; becaufe the dura mater every way adheres firm- ly to the iknll, but much more firmly in thofe parts which are the feats of the finufes. Indeed they receive liquors injeefed by the arteries ; but whether thofe 1 tranfude through the fmall exhaling arterial veffels, or whether they firfl make a complete circle through the veins, as indeed is much more probable, we are not yet furnilhed with experiments enough to determine. 333. Thus all the blood of the brain is finally con- veyed into the jugular veins, wffiich are very dilatable, and for that reafon guarded with valves to prevent a return of the venous blood from the right auricle, being at the fame time furrounded w'ith a good deal of cellular fubflance. For as to the blood which goes to the head by the vertebral veins, it is a very incon- fiderable quantity ; but the ample jugulars anfwer in fuch a manner to the great upper vena cava in a di- reft courfe, that they afford the highway for the blood to Chap. XI. BRAIN and NERVES. i 6 i to return back to the heart. The branches of thefe are commonly the fame with thofe of the brain ; name- ly, the veins of the brain, and thofe of the face. 336. The external jugular is a cutaneous vein of the neck, w'hich produces the temporal one, and is united with the internal jugular at the bafis of the lower jaw ; and the fame fends a branch through the os maxillare into the tranfverfe fmus. The internal vertebral empties itfelf through the tranfverfe procelTes of the neck into the tranfverfe fmus as often as the canal belonging to it is opened. 337. The two lateral finufes of the fpinal marrow run along its whole length, are joined to each ver- tebra by a femicircular arch, and at lafl are united with the jugular and occipital finufes : they fend branches, however, to the fpinal marrow, joined W'ith the ante- rior and pofterior fpinal vein. 338. The veins form innumerable anaftomofes with one another, that the blood may return with the great- eft eafe from the head, of which the repletion is very dangerous. The brain is alfo more eafily evacuated in the time of infpiration, and fubftdes during that period when the ficull is opened, but fwelk during the time of exfpiration. Hence, blowing the nofe, fneezing, and coughing, are dangerous to thofe whofe brain is fwelled by retained blood. 339. Whether or not there are lymphatic veffels to be feen in the brain, is by fome queftioned. Indeed, we read defcriptions of them in the pia mater, and in the larger choraidal plexus ; but, for my own part, I have never been able to fee them, and poflibly there are none to be feen, fmce there are no conglobate glands in the bran, which are always near at hand wherever any of thefe veffels are to be found. As for the various accomts wiiich are given of the pituitary glandule, of the iniundibulum, and of the duds which lead from thence iito the veins of the head, abforbing and tranfmitting a water from the ventricles of the brain, they are no fupported by anatomical experi- Y ments : i62 brain and nerves. Chap. XL ments : which make it more probable, that the vapour which is fecreted into the ventricles of a healthy perfon is, in like proportion, abforbed again by the inhaling veins ; or, if any part abounds, that it defcends through the bottom of the ventricles to the bafis of the Ikull, and from thence into the loofe cavity of the fpinal me- dulla. That this is the cafe, appears from palfies which enfue on one fide of the body after apoplexies ; and from the bifid fpines or watery tumours in the lower part of the fpinal medulla, following in thofe who have an hydrocephalus. 340. It now remains for us to fpeak of the encepha- lon itfelf. But many are the parts included under this general denomination. By the brain, properly fo call- ed, we underftand that upper and foft vifcus which is contained in the fkull, and which is lodged by itfelf in its fore-part; but backward it is incumbent over ano- ther confiderable part, called the cerebellum, which lies in the pollerior and lower cavities of the occipital bone, under the membranous tentorium, which parts it from the brain. Its lower, middle, and white portion, de- fcending before the cerebellum, is in part called xhtpons, and in part the medulla oblongata. 341. The figure of the brain refembbs that of half an egg, which is deeply divided longitudinally, but not cut through above half way, into hemifpheres refem- bling the fourth part of an egg. Both the upper and lower furfaces are full of many gyri dr convolutions, which pretty deeply cut or divide the l^ain with round ends or angles into undulated portionSf But the largeft is that which afcends on both fides outwards from the fidcs of the fella turcica, and divide? the hemifphere into two lobes. Upon the furface the faid lobules or portions lies the cortex, extremel)yfoft, and inclined from a yellow or red to a grey or alh colour, being the mod tender of all parts in the hunan body : this in- wardly is filled with the medulla, v^ich is almoft per- fedly white, but redder in the fctu^, in many places, it is perforated by red arteries, whioi are more fimplc I and Chap. XI. BRAIN and NERVES. 163 and perpendicular, or ftraight, than in other parts. This medulla is more folid and more capable of fu- ftaining its figure, notwithftanding it is very foft, and abounds in a greater quantity than that of the cortex. The greater pofterior branch of the carotid artery (317.) firft divides the right and afterwards the left hemifphere of the brain into an anterior lobe, which is the larger; and a pofterior lobe, which is the lefs. 342. The fabric of the cortex has been a long time controverted ; but it is now fufficiently evident, from anatomical injeftions, that much the greater part of it confifts of mere veflels, which are every way in- ferted from the fmall branches of the pia mater, de- tached like little roots into the cortical fubftance, and conveying a juice much thinner than blood in their natural ftate, although in fome difeafes, and by ftran- gling, they often receive even the red parts of the blood, more efpecially in brutes and birds. The re- maining part of the cortex, which is not filled by any injection, is probably either an aflemblage of veins, or of yet more tender veflels ; for no other diflimilar parts are apparent in the cortex, whilft it is in an entire or natu- ral ftate ; from whence one may conjedture fome part of it to be tubular, and the other part folid. As to glandules making the fabric of the brain, that notion has been difcarded by univerfal confent ; nor indeed has there been any other opinion received with lefs pro- bability than this. 343. In order to gain a knowledge of the nature of medulla, we are to confider the anatomical ftrmfture of this part of the human brain, compared with the brains of brute animals and fiih. Therefore this part of the brain, which follows immediately under the outer gyri or convolutions of the cortex, is of a white colour, and becomes gradually broader and more a- bundant ; fo that, at length, it makes up the whole oval fection of the brain, except only the gyri in the furface, which makes the cortex. In this part, the two hemifpheres of the brain, as before obferved, are y 2 divided 164 BRAIN AND NERVES. Chap. XL divided but half way through ; which hemifpheres here continue their cohefion with the medulla in the mid- dle. That part of the medulla which is extended un- der the falciform procefs, but at fome diftance from it, is called corpus callofum ; in the furface of which run two parallel white (tripes, formed by the pulfation of the arteries : thefe (tripes diverging forwards, and termi- nated at the place where they mingle together in the fore-part, are thence divided backwards. But the an- terior extremity of this callous body is loft in the fub- (tance of the crura, coming from the anterior lobes of the brain : the polterior, w'hich is broader, with a firorter curvature in the (liape of a nail, is brought in- wards ; and the other column defeends into the inferior horn of the ventricle, whence it is continued along w'ith the longer one into the hippocampus. Moreover, the W'hole furface of this callous body is (treaked with tranf- verfe fibres, which are continued, but extenuated, into the next adjacent medulla of the brain itfelf. Even the interior fubfiance of this body is of a ftriated nature, and its lower furface has its future and fibres tranfverfe. 344. x\s to the remaining parts of the brain, a feru- tlny is more difficult to be made into them : for the brain is not a folid body, but begins to be hollow in- ternally from the lower part of its medulla, which is incumbent upon the multiform bone, at which place the greater crus of the brain paffes out from it ; and in this cavity the medulla is only covered wnth the pia mater, which afeends backward, and then turning continues its courfe forward and upward. Next, the brain divides itfelf near the pofterior extremity of its callous body; and, at the fame time, fends one of its firorter pofterior portions into the pofteriqr lobe of the brain, turning its extremity inward. But the anterior por- tion is continued a long w'ay by the fide of the callous bo- dy, parallel to the horizon ; and turning its horn outward, which there grows broader, it is terminated in the anterior lobe of the brain. This cavity, of w'hich t'lere is one in each hemifphcre of the brain, is called its triangular Chap. XI. BRAIN and NERVES. 1^5 or anterior ventricle; and it is naturally filled with a vapour, which is frequently condenfed into water or 345. This cavity is full,- without any intermediate fpace, by the clofe meeting together of the fides of the upper and lower medulla. The lower fide or pavement of this part is varioufiy figured. In its forepart, it forms a horn ; below which there is a rifing moderately con- vex, and of confiderable length, diverging backwards, covered with a membrane that is extremely vafcular ; and, being outwardly of an afli or grey colour, is called the corpora Jlriata ; becaufe inwardly they exhibit to the view, together with much cortex, alternate white oval (freaks, parallel to one another, longer on the back part ; befides, as it were, lefTer medullary fpots and micse. More inwardly and backward, there are two other fimilar eminences, more of an egg-like fhape, towards the third ventricle and other parts, moffly cinereous on the outfide, obfeurely (friated, and fo incumbent together, that they frequently co- here on the upper part, where they are confounded with the cortex ; and thefe, .continuing their courfe through the horn of each anterior ventricle, defeend to the bafis of the (1-tull, and there generate the optic nerves, of which they are called the thalami. Betwixt the faid (friated bodies and thofe thalami, lies an inter- mediate, parallel, white, and (freaked medullary por- tion, called the double femicircular centre, produced from the anterior commixture, and frequently from the crura of the fornix ; but efpecially from the medulla it- felf, before the thalami of the brain. This commixture is broad, (frong, and joins together the anterior part of the brain before the thalami. The double centre, which is broadeff behind, arifes with many fibres, from the junction of the foot of the hippocampus with the medulla of the brain. But-the corpora (friata, with the thalami, conlfitute the medullary crura of the brain ; which, in the bafis of the cerebrum, lie over the me- dulla of the cerebellum, and are joined together at the extremity t 66 BRAIN AND NERVES. Chap. XI. extremity of the bridge above-mentioned. At the place where they approach neareft to one another, each fends out an hemifpherical mamillary eminence. The fibres of the medulla of the brain itfelf, mixed together with the medulla of the cerebellum, defeend into the medulla oblongata ; and, being then collefted into a bundle, they go to the corpora pyramidalia. 546. It is to be obferved, that the corpus callofum me- dium projects or rifes up in the common axis or middle of thofe ventricles. Behind, this body lies contiguous and incumbent on the fornix ; but, before, there are two fi- milar medullary partitions, which defeend from this body the whole length of the corpora ftriata ; and this part, which in its middle includes an anonymous cavity, goes under the name of feptum pellucidwn. This feptum is con- tinued to the fornix ; that is to fay, the four-horned me- dullary trafts, which take their anterior origin from the medulla of the brain, and fometimes the mamillary pro- tuberances, and the commixture which we have mention- ed : and behind that, particularly under the thalami, and often from the double centre and crooked line of the tha- lami. This fornix is incumbent upon an interval of the flriated bodies, and upon another interval of the thala- mi : from whence it degenerates partly into a broad thin fimbria; and partly into another tubercle, which is evidently continuous with the fornix and callous body of an half cylindrical figure, and furnifhed with an ap- pofite fimhria. Thefe defeend into the lower anterior horns of the ventricles ; and at laft: terminate outwards by a fort of convex fulcated end, imprinted by the gyri of the brain, and terminated by a foot, having as it were four furrows ; whence the name of hippocampus^ which externally are covered by exceeding thin medul- lary plates, but are inwardly of a cortical fubftance. At the beginning of the divifion of the foot of the hippo- campus, the tecnia ends in two white ftriEC, a long and a fhort one, inferted into this foot and into the brain, or one inferted into the inmoft part of the unguis. A like protuberance is continued in the poftcrior horn of the ventricle. Chap. XL BRAIN and NERVES. 167 ventricle, crooked inwards at its extremity like the claw of a bird, to which a continuous column occupies the hinder part of the bafis of the horn of the defcending ventricle, which is continued with the corpus callofum. Betwixt the departing poflerior crura of the fornix, the medullary portion, which is behind the middle plexus of the ventricles, and painted with tranfverfe and pal- mated ftreaks, is called the pfalteriim or harp, 347. Within the anterior or lower part of each of the ventricles, begins the vafcular plems^ called choroides, included in the pia mater only, it lying naked in the reft of the cavity of the fkull, made up of a great many fmall arteries (3 17, 318.), together with little veins ori- ' ginating from the larger trunk (325.); all which nu- merous veflels, joined together by the pia mater, re- femble a curtain varioufly folded. With thefe are in- termixed many fmall pellucid glandules of a round fi- gure, refembling hydatids. It afeends from the bafis of the brain, through the defcending horn of the ven- tricle, and thus is dilated as it goes upward ; but, thence, becoming narrower, it goes on with the optic thala- mus, to the pofterior extremity of the feptum lucidum. When thofe plexufes have reached the anterior extre- mity of the thalami, being afterwards reflected and u- nited together into one very large vafcular plexus, they gradually defeend through the crevice of the third ven- tricle as far as the pineal glandule, and then are conti- nued into the pia mater of the pofterior lobes of the brain. From this plexus, doubtlefs, proceeds the inter- nal warmth of the brain, with its exhalation and inha- lation. But the choroidal plexufes become very broad where the anterior ventricles of the brain begin to de- feend ; and thence, contrafting gradually downward, they project their extremities to the ends of the anterior ventricles, covered only with the pia mater. 348. Betwixt the thalami, applied one to the other almoft with a plain furface, there is a natural fiflure ter- minating the crura of the brain, which meet together ill the bafis of the fkull j and this is called the third ven^ trick. i 6 S BRAIN AND NERVES. Chap. XI. tricle. It leads by a declivity, like a funnel, forward into a concave column ; which, though hollow in brutes, is yet evidently lefs tubular in man, and connefted to the pituitary glandule. 349. This is compreffed on both Tides, fimple, of un- certain flrufture ; in the anterior part almolt round, and of a reddiTn colour 5 the pofterior part lefs, cinereous, broad tranfvcrfely, covered with the pia maier of the brain : it lies upon the proper impreiiion of the fella turcica, and feems to be a kind of appendix to the brain. 350. Backward, the thalami are conjoined together in the bottom of the ventricle, by a medullary fafcia, or poflerior commixture, and by a fmaller tranfvcrfe chord ; from which a crooked white ftreak goes out on both fides in the upper part, which lofes itfelf in the double centre, in the anterior commixture, and fometimes in the crus of the fornix. On the fore and upper part, the thalami fpring out of a protuberance, which is form- ed by the triangular fornix lying between the two tha- lami. 351. This little eminence feparates the upper trian- gular cavity of the third ventricle, filled up with the for- nix in fuch a manner, from the inferior calamus fcrip- torius, that the cavity is continued both from the ante- rior and pofterior extremity of the third ventricle, from the top to the bottom. But even the anterior com- mixture is a medullary ftreak which unites the thalami before the anterior crura of the fornix. 352. Again, behind the thalami, thofe tranfverfe fi- gured eminences of the medulla meet together, which conjoin the medulla of the right and left pofterior lobes of the brain. In this part, backward, are cut out four oval eminences, which are outwardly fmaller, called the nates and teftes^ and which are of a fubftance inwardly cortical, but outwardly medullary. Upon thefe is feated a cortical glandule, fomewhat oval and conical, fpread with many fmall »effels, into which the choroide plexus here degeijerates ; this is the pneal glandule fo much cele- Chap. XI. BRAIN and NBRVES. celebrated, and fo frequently difeafed, and joined to the brain by fmall foot-ftalks fent into the linea alba thro’ the thalami in their paffage forwards. Between this eminence, on which thefe four protuberances are cut out, and the crura of the oblong medulla, palfes a groove or channel in the fame direction from the third to the fourth ventricle, manifeftly open, refembling an aque- duct. 35^. The whole medulla of the brain is, in its lower part or bafis, collected together into two very thick compreffed columns, dilHnguidied in their furface by a line running according to their length ; which have in- ternally a cortical fubflance, and are the crura of the brain. Thefe, meeting together backwards, are cover- ed by the fubjacent crura of the cerebellum, and are inferted by apparent ftrata of fibres into the pyramidal bodies of the medulla oblongata ; and with the other deeper fibres, which feparate the inner tranfverfe fibres that come from the cerebellum from the preceding, meet together with the medulla cerebelli to make up the beginning of the medulla oblongata. 354. The cerebellum^ as it is lefs, fo it is more fimple than the brain. It has two lobes, but no where deeply parted, united above and below in their centre to a ring of the fame fabric with itfelf, called the vermis, at the fide of which there is a fmooth eminence of the fame na- ture with the cerebellum itfelf. This part of the ence- phalon contains a great deal of the cortex, with a lefs proportion of medullary fubftance. And here, like- wife, the cortex is placed in the circumference, but marked with gyri or convolutions, which are rather pa- rallel to each other, fo as to form circles. Thus the fmall lobules or portions are diftinguilhed, but not deep- ly, and afterwards fend out each of them their medulla; which is, by degrees, lb collefted together in rays or branches, meeting in one trunk, that the whole re- fembles the figure of little trees. This medulla, col- lected together into the large crura of the cerebellum, and marked in the inner part with ferratcd cortical lines, Z inter- 170 BRAIN AND NERVES. Chap. XI. interwoven with one anoiher, bath a threefold termina- tion. One part afcends towards the bans of the nates, where it joins with the medulla of the brain under the teRes ; but the right and left parts of it are joined to each other by a trardVerfe medullary ftria behind the nates. From this, forne diftinct fibres afcend outwards, and ioin thernfeives to the tranfverfe ones of the bridge. Between thefe firR proceffes of the cerebellum, is ftretched a medullary lamina, behind the fourth ven- tricle, lending forth fibres beyond the procefs. Ano- ther portion defeends into the fpinal medulla, and ter- minates in peculiar nail-like protuberances, which are both anonymous, and have other cortical portions near them, A third portion, which is larger, and fituated in the middle, goes tranfverfely downward under the crura of the brain, which it embraces ; and by twice intermixing alternately with tlieir tranfverfe medullary fibres (^52.), it is in a great meafure confounded toge- tlier with them. t;5 5. Thus is produced from the crura of the brain defeending above thofe of the cerebellum, and from, the medulla of the cerebellum tranfverfely furrounding that of the cerebrum, the pons^ at firR almoR oval, but more blunted on both lides, deprefled in the mid- dle, and inferibed on all fides with tranfverfe fibres. Then the meduJla oblongata, continuous to the pons, is internally variegated and Rreaked with a fubRance like the cortex, and defeends of a conical fliape, in- clined to the great foramen in .the occiput. This me- dulla has two pair of tubercles before the pons ; the outermoR of the figure of an olive, and the innermoR of a pyramidal fliape, for they lefl'en downward like a cone; and thefe are immediately divided by a fulcus, through which the pia mater enters. But betwixt that medulla and the worm-like procefs of the cerebellum,, is formed a cavity, limited by the four leffer proceffes, which as they afcend or defeend is at firR narrower ; but above the tubercles (354-) it grows broader, and is of a rhomboidal figure : it is called the fourth ven^ tricky Chap.XI. brain AMD NERVES. iji trick. It is Ihut in its back-part by the valvula magna, dr a medullary velum, uniting the procclTes going from the cerebellum to the nates and vermis, and tranfrcrfe ftria lying under the idles, and Ihurting the ventricle behind, (354.) I'his ventricle has a moderately large fulcus or furrow, having fwelled lips on each fide inferi- bed on the medulla oblongata, and anl'wcring to the canal that is covered by the nates and telles, called the In this iaft ventricle, as well as in the foregoing, is lodged the plexus choroides, only lefs in bulk, together with an upper fulcus called calamus. Each of thefe fulci is continued down along the me- dulla fpinalis, both in its anterior and pollerior fide j more evidently in the former, but lefs fo in the latter. Tranfverfe fibres are detached in its upper part from the right to the left fide, both of the medulla oblonga- ta and fpinalis. But two or three of the tranfverfe {freaks that arife from the eminences which intercept a fulcus, are inferted into the foft part of the acouflic nerve ; others go to the eighth pair, and others of the fame kind afeend to the crus of the cerebellum. 356. All the medulla of the brain and cerebellum goes out from the fkull, through particular openings towards certain parts to which it is deftined. The fmaller bundles of this medulla we call nerves ; but the larger, defeending through the fpine, we call the medulla fpinalis^ which is a continuation of that called oblongata But the nerves, wdiich are bundles of the medulla, and very foft in their origin, are com- pofed of ftraight parallel fibres in diftindl threads. Thefe nervous cords, after they have gone forward fome length, covered with the firm pia mater of a red- difh colour, are afterwards united into a more tougfi or permanent firing ; and then, conjoined, divided, and in the neighbourhood of others like themfelves, they haften through a cellular texture to their proper open- ing in the dura mater, and thence run down through the intervals of the channels formed by that mem- brane, till they meet with an opening in the fkull, out Z 2 of BRAIN AND NERVES. Chap. XL of which they pafs through the membranous funnel of the dura mater. The nerve, having arrived without the Ikull, is commonly furrounded by the dura mater, fo as to become very folid and firm. Thus it is in the optic nerve, in the fifth pair, and in others ; but in fome again there does not appear to be any dura mater furrounding the nerve, as in the olfactory nerves, in the foft portion of the auditory nerve, and the interco- ftal. The nerves now defcend naked or lefs fenced betwixt the mufcles, detaching their cords or threads of which they are compofed, and are ftill made up of the medulla covered by the pia mater. Many fmall threads of this kind are joined together into larger, by the union of the cellular fubftance that furrounds them, through which run many fmall arteries and veins intermixed ; and fometimes fat itfelf is therein lodged. But in general the outer covering, common to the whole nervous bundle, is either derived from the dura mater, or at lead is a hard plate of the cellular fub- ftance, wherein all the fmaller threads are contained and united into one nerve, often refeinbling a true membrane. g57. It is common to all the nerves of the head to arife and pafs out from the lower part of the medulla of the brain or cerebellum. The o^'t?^(5/;ywerx;earifes with lateral fibres from the interval betwixt the anterior lobe of the brain, but with direct fibres from the medulla of the anterior lobe itfelf. A great part of the optic nerve fprings from the thalami (345.), but fome part hkewife from the crus of the brain, while the nerves decullate through its fubftance. The third arifes from the loweft crus or the medulla of the brain behind the mammillary bodies. The fourth, which is either fnnple or tntid, fends a procefs from the fide of the cerebellum to the teltes. The fifth arifes plainly Irom the peduncles of the cerebellum itfelf. The fixth out of a fulcus (354.), deep from the bottom of the pons betwixt that and the medulla oblongata. The feventh arifes with one part fpfter from the medulla oblongata, and by two tranf- Chap. XL BRAIN and NERVES. 173 verfe ftrise, from the fourth ventricle itfelf ; and with another part harder from that portion of the crus of the cerebellum which lies next the pons. The eighth nerve arifes from the interval betwixt the olivary and pyrami- dal bodies or protuberances ; and, according to the obfervation of other eminent anatomifts, from the fourth ventricle likewife. The ninth arifes from the corpora olivaria and pyramidalia. The tenth, by rea- fon of its double root, is reckoned a nerve of the neck, going out with an arch, in company with the upper and lower adjacent nerve. There is, therefore, no nervous branch that arifes properly from the cerebel- lum, unlefs it be the fifth ; for the anterior nerves, the clfaftories, optics, and third nerve, come from the brain only ; and all the reft from thofe parts where the medulla, both of the brain and cerebellum, are con- joined together. 358. The fplnal medulla is a kind of very foft me- dullary rope or appendix to the encephalon, continued down from the medulla oblongata, as low as the fecond vertebrae of the loins. In the neck its anterior and po- fterior fides are flat, laterally convex, but in the back it is four-fquare. It is largeft where it goes out from the head ; from thence it is fmaller in the top of the neck ; in the lower part it is larger ; but fmaller again through almoft the whole back ; thicker in the lower, oval, and conical part of it ; and laftly it ends in tubercles. The pia mater is a proper integument to this part as well as to the brain, fince it enters the foremoft fiflTure deep- ly, and divides the medulla almoft into two. The cor- tical fubftance which lies within it is obfcure. It has its anterior artery produced in the fkull, from the branches of the vertebrals. This artery is retrograde, and defeends through the whole length of the pia ma- ter, perpetually making alternate finuous flexures, which form inofculations about many but not all of the nerves, with branches of the vertebral, intercoftal, lumbar, and facrolumbar arteries j till at laft, being covered with a peculiar coat from the pia mater, it goes 174 BRAIN AND NERVES. Chap. Xf. goes out and difappears at the coccyx. In like man- ner the two pofterior arteries, which are lefs, arife and are diftributed from the lower arteries of the cerebel- lum, and are more ferpentine, and frcqua;)tly inofeu- lated among themfelves. The fpinal veins defeend, to- gether with the arteries, from the brain itfelf, fending out branches in like manner on each fide, which ac- company ^'he nerves like fo man/ circular fmufes, fixed in the dura mater, and correfponding to the number of the vertebrae, all which fo communicate one with another, that each has on all fides a dircdl confent both with the uppermoft and lowermoft ; and, after having fent out branches that join the vertebral, inter- coflal, and lumbal veins, they unite with thofe of the facrum. The uppermofl; of thefe fmufes inofculates with the anterior occipital fmufes (332.) ^59. But there is another covering, not fpread with any veffels, which furrounds the fpinal medulla lool'ely and at a diftance, and is pretty firm, of a w'atery clear- nefs, called arachnoides ; and which being longer than the pia mater, is extended to the bottom of the os fa- crum, w'here the nerves, only defeending from the medulla, are collcded by it into a fafciculus. But in what manner it goes out, together with the nerves, has not been hitherto deferibed. Betw'een that membrane and the dura mater there exhales a vapour, w'hich is frequently condenfed into a reddilh water, and produces a true dropfy. 360. Laftly, the dura viater, belonging to the fpinal medulla, and continued from that of the cerebellum, fur- rounding the arachnoides, and from thence defeending to the bottom of the os facrum, being larger at its begin- ning, at the bottom of the neck, and at the loins, but flenderer in the back, and being conneded ulti- mately by many ligaments to the os facrum, it at laft difappears in a llender cone. As the nerves pafs cut through this membrane, it gives them an external co- vering ; and diredly thickens or fwells with them into ■ 3 i ganglion, or bard, oval, reddifli-coloured knot. To Chap. XL BRAIN and NERVES. 175 this hard covering of the dura mater internally adheres a ligament denticulated at the interval of each of the nerves, which arifes from the Ikull near the courfe or' paffage of the ninth pair of nerves, tying the arach- noidcs to the dura mater by triangular produdions in each of the intervals of the nerves, and betwixt the anterior and pofterior bundles of the fpinal nerves down to the bottom, and twelfth vertebra of the back. Ex- ternally there is a fort of fat furrounds the dura ma- ter, and alfo lines internally the covering of the verte- bras of the fpine, which by this means are fo adapted like a tube to the medulla fpinalis, that the latter is not liable to be comprelfed by the bending of it in any pofition. 361. The fibres of the fpinal medulla, in dropfical fubjeds and in brute animals, appear very difiind. Thefe medullary fibres go out from the whole anterior and pofterior fides of this long appendix ; after which, the anterior cords are commonly wrapt up in the pia mater, in which they converge together Idee rays into a larger fafciculus ; to which alfo join fimilar threads in another bundle from the pofterior fafciculi joining to- gether into one nerve, which, pafiing out through the holes of the dura mater, produces a nerve betwixt each two vertebrae. Thefe vertebrae are about 30 in num- ber. In the neck, numerous radiated nervous fibres compofe one large and almoft tranfverfe nerve. In the back they defeend, in general, of a fmaller fize ; but fo that the lower and larger ones are commonly joined clofe to one another. The large and long lumbal ones join to form the cauda equina. The loweft nerves of the os facrum are the leaft, the uppermoft ones large. Many of the dorfal nerves, together with the lumbal ones, and thofe of the os facrum, covered with their proper membrane from the pia mater, accompanied with their arteries, and inclofed in the arachnoides, make up that rope which is called the cauda equina. 362. Thofe nerves are afterwards diftributed to all parts of the body in a manner very complex, and not here 17<5 brain and nerves. Chap.XE here to be defcribed. But we muft not omit to ob- fervc, that all the fpinal nerves, except one or two in the neck, have both an anterior and poRerior trunk. Ihis is only fent to the mufcles. It produces a nervous root, which joining the other adjacent nerves, and having gi- ven a fmall circle that proceeds from the fixth nerve of the brain and the fecond branch of the fifth, comes through the pterygoide canal, and forms one of the prin- cipal nerves of the human body; which, communicat- ing with almolt all the other nerves of the whole fyftem, fends out nervous branches to the heart and all the vif- cera of the abdomen. The fame has as many ganglia as roots from the medulla, unlefs where many of them join into one ganglion. It communicates in various places with the crural, brachial, and diaphragmatical nerves, alfo with thepar vagum and ninth pair of nerves. The other primary or capital nerv^e is the eighth or n^ague nerve, arifing from the brain, and joining itfelf to the intercoftal in the bottom of the neck, in the thorax, and in the abdomen ; this palfes out of the fkull in three cords, of which the larger fends branches to the larynx, gula, lungs, and the cardiac plexus itfelf (99.) alfo to the oefophagus, ftomach, and liver. The third of thefe is the phrenic nerve, arifing from molt of the lower nerves of the neck and arms ; and fometimes, be- ing increafed from the root of the fpinal nerve, it de- feends by the fide of the pericardium, and inferts itfelf into the upper face of the diaphragm; but below it re- ceives nerves from the great plexus of the intcrcoftal nerve. Lafily, the accejfory nerve, arifing by many fmall roots from the fix or feven uppermolt pofterior nerves at the neck, and from the medulla oblongata, joins the nerve of the eighth pair going back again into the Ikull, and feems, by this means, to make a confent betwixt that important nerve and the fpinal medulla. Moreover, the nerves of the limbs have at their origin plexufes or knots, and are, on account of their length, harder and firmer in their fBbftance, and much larger, than the great nerves which go to the vifeera : thofe which Chap.XI. brain and NERVES. 177 which go to the hand, arife from the four lower nerves of the neck and firfl of the back 5 but thofe of the lower extremity from the nerves of the loins and os facrum. -^6^. The nerves divide into branches like the blood- vefl'els, but in acute angles, and often in a courfe ina- nifeftly retrograde, growing gradually fofter and Icfs in bulk, though fometimes they become thicker as they recede from the brain, till at length their ultimate ex- tremities, which are feldom vifible, feem to terminate in a pulp, by depofiting the firm integuments with which they were covered, after the manner which we obferve in the optic nerve. But the rectilineal courfe of the fibres, continued from the brain itfelf, is fuch, that it is never broken off by the divilion or fplitting of a nerve into fmaller threads, which only recede from each other by an opening of the cellular fubftance that tied them together. This appears from the diforders, which are determined not to ail, but only to fome fingle parts by injuries of the brain ; as a lofs of the voice, deafnefs, dumbnefs, and palfies of particular mufcles. They are connecled in their courfe by the cellular fub- ftance to the adjacent parts, but have hardly any elafti- city ; whence they do not fly back after being divided, but only expel, by the contradlion of their integuments, the foft medulla w^hich they include. But though they are irritated ever fo much, they are neither contracted nor are they rendered flrorter during the motion of the mufcles which they produce. A great many nerves are fent into the mufcles ;■ many of them go to the ikin ; but fewer to the vifcera, and feweft of all to the lungs; none at all to the dura and pia mater, arachnoides, tendons, capfules, and ligaments, and laftly the whole fecon- dary membranes. They make frequent inofculations with each other, or out of one trunk are parted into many branches ; and it is principally in thefe meetings of their branches, arifing from different trunks, that the nervous ganglia are formed ; namely, hard nervous tumours, for the moft part replenifned with blood-vef- fels, and included in a firm membrane, but of a ufe and A a ftruCture 173 BRAIN AND NERVES. Chap.XL ftrudture as yet not certainly known, in which the ftraight courfe of the nervous fibres is interrupted. The nerves of the fenfes only are excepted from thefe gan- glia or knots, together with the eighth pair; but they feein in a manner efiential to the phrenic nerves, to the fifth pair, to thofe of the limbs, to the fpinal and to the intercofial nerves, which lafi dre truly fpinal nerves. 365. Thus far we are taught by anatomy concern- ing the brain and nerves ; it remains from hence, that we explain the phyfiological ufes of thefe parts. Every nerve, therefore, that is irritated by any caufe, produ- ces a fitarp fenfe of pain. But -we mufi; reckon the mind to be changed when any change happens to the body. It is the medullary part of the nerve which feels the pain. If the nerve was endued with any peculiar fenfe, that fenfe perifiies when the nerve is comprciTed or diflefted ; the fenfes of the whole body are loft by a Gompreffion of the brain ; and of thofe parts whofc nerves originate below the feat of preflure, if you com- prefs the fpinal marrow. If certain parts of the brain are comprefled from which particular nerves arife, then thefe fenfes only are loft which depend on the nerves, as the fight or hearing. Thofe parts of the body which receive many nerves, as the eyes and penis, have the moft acute fenfation ; thofe have leaft fenfibility which re- ceive few nerves, as the vifeera; and thofe which have no nerves, as the dura mater, tendons, ligaments, fecun- dines, broad bones, and ligaments, have no fenfation. 366. It is not verv obfeure, that all fenfation arifes from the impreflion of a fenfible object on fome nerve of the human body ; and that the fame is then reprefented to the mind by means of that nerve’s coimedion with the brain. But this feems to be falfc, that the mind perceives immediately by means of the fenforia and branches of the nerves. For this opinion is refuted, by the pains felt after amputation, the ceflation of all pain when the nerve is comprefled, and the deftruefion of the fenfes by difeafes of the brain. And that the cf- fed of the fenfes is preferved in the brain, is evident from Chap. XI. BRAIN and NERVES. 179 from the lofs of memory which follows when the brain is injured or compreffed ; alfo from the delirium which happens infome difeafes, and the Ifupor and fleepinefs which happen in others. We have already obferved, that the dura mater has no fenfation. 367. Another otEce of the nerves is to excite mo- tions, even the moft violent ones, in the mufcles. When a nerve is irritated, the mufcle to which it goes is immediately convulfed ; or if it fends branches to fe- A^eral mufcles, they are all convulfed at the fame time. This happens during the life of the animal, and a little after its death while all the parts are moift. By a great irritation other mufcles are thrown into convulfions, and afterwards the whole body. Nor is it neceffary that the nerve fliould be whole ; for even when it is cut, an irritation of it will excite fimilar motions in the muf- cles. On the other hand, when a nerve is compreffed or tied, a palfy follows ; for the mufcles which have their nerves from that one lie unmoved, when they are commandediDy the will to a£l. They alfo recover their motion when the compreffion is removed, provided the nerve has received no hurt. 368. But the medulla of the brain, being vellicated or irritated deeply in its crura, dreadful convulfions en- fue throughout the whole ; and this without any excep- tion, whatever be the part of the brain fo affedled ; nor is there any difference in the brain, cerebellum, or corpus callofum. The fame confequences alfo follow, if the fpinal medulla be irritated. But if the encephalon it- felf be compreffed in any part whatever, there follows thence a lofs of fenfe and motion in fome part of the body, which muff be the part whofe nerves are de- tached from the affefted or compreffed quarter of the brain. This is clearly evidenced from experiments which have been made on particular parts of the brain difordered : as from thofe, for inftance, in which the origin of the nerves are compreffed, the voice is loft ; or the motion of one arm or leg, or one fide of the pharynx, is abolilhed. But in the injuries of the fpinal A a 2 medul!a_j i8o BRAIN AND NERVES. Chap.XI. medulla, it is ftill more evident, that thofe parts, which receive their nerves arifing from the place injured in the medulla, are either convulfed if that be irritated, or rendered paralytic if it be comprelfed. But when any more confiderable or large portion of the brain fuf- fers a comprelTure, either from blood, water, fcirrhus, an impadled bone, or other mechanical caufes, the greateft part, and. then the whole, of the body lofes its power of motion ; of thofe organs which obey the will ■when the majady is in a Iclfer degree, and of them all when it is greater ; all which diforders ceafe upon re- moving the compreffing caufe. Lallly, if tlie fpinal medulla, entering the neck, be injured, death imme- diately follows ; becaufe from thofe parts principally arife almoft all the nerves of the heart (99.) 369. Thefe things being conhdered, there feems to be no doubt, but the caufe of a.il motion in the Iruman body arifes from the brain .vidu its annexed cerebellum and fpinal marrow ; and that it thence proceeds thro’ the nerves to all the mufcular parts of the body. The caufe, therefore, of this motion cannot refide in the parts themfelves, becaufe otherwife the moving caufe W'ould continue to adt after being feparated from the brain; nor would it be increafed by irritating the brain, or weakened by a contpreffure of it. 370. V/hether or not is there in the brain any principal part, in which refides the origin of all ntotion,the end of all the fenfations, and where the foul has its feat? Whether is this proved by the frequent obfervation, that the fciifes are fometimes entire, and that motion likewife remains tho’ the brain is grievoufly hurt. Is it in the corpus cal- iofum? Or is this fhewn by the greater fatality of wounds or difeafes in the corpus callofum ? Is this body fuffi- ciently connected with the nerves? Are there any ex- periments which deduce from thence the fifth, feventh, and other nerves ? Doth not the fame or even greater mortality of wounds in tlie medulla fpinalis prove the fame thing ? Yet this is not the feat of the foul, feeing, though it is compreffed or even deftroyed, the perfon Chap. XL BRAIN and NERVES. i8i will furvive a long time, with the perfe£l ufe of all his fenl'es. Nay, this opinion is oppofed by very many facls : birds have no corpus callofum ; and wounds in that bo- dy are not in the leaft more mortal than thofe in other parts of the brain, as appears from undoubted experi- ments. 371. But neither is the pov/er of the cerebellum greater in exciting the vital motions, nor are the pro- provinces of vitality and animality diftindl ; nor does the cerebellum produce the nerves of the heart and o- ther vital organs, and the brain thofe which go to the organs of fenfeand voluntary motion. From the cere- bellum the fifth nerve is mofi; evidently produced ; but that gpes to the tongue, pterygoide, buccinator, tem- poral, and frontal, mufcles, the lap of the ear, the eye, the nofirils, all which are parts either moved by the will, or deftined for fenfe. Again, the fame nerve, like the eighth, fends vital branches to the heart and lungs, animal and voluntary ones to the larynx, and fenfitive ones to the ftomach. Again, it is not even true, that diforders of the cerebellum bring on fo certain and fpeedy death. For certain experiments, even of our own making, Ihew that it has borne wounds and fcirrhi, without taking away life ; nor is it much different from the brain, only that it is fofter and more tender; and laflly, w'e have known, and that not very rarely, wounds of the cerebellum cured. The power, how- ever, of this part, in exciting convulfions, is fomewhat greater. 372. Concerning the feat of the foul, we muft en- quire experimentally. In the firft place, it muft be in the head, and not in the fpinal marrow. For though this is obftrudled, the conftancy of the mind remains the fame. Again, it appears, from the experiment of convulfions arifing when the inmoft parts of the brain are irritated, that it lies not in the cortex, but in the medulla ; and, by a probable conjedture, in the cru- ra of the medulla, the corpora ftriata/ thalami, pons, medulla oblongata, and cerebellum. And again, by ' another 282 BRAIN AND NERVES. Chap.XL another not abfurd conjecture, where the origin of e- very nerve lies, as the firfl; origins of all the nerves ta- ken together make up the fenforium commune. Are the fenfations of the mind reprefented there, or do the voluntary and neceffary motions arife in that place? This feems very probable. For it does not feem pof- fible, that the origin of motion can lie below that of the nerve ; for although it fhould be affumed gratis, that fome part of the nerve is immoveable, or infenfible, ■yet that is altogether fimilar to the remainder of the nerve. Nor can the origin of motion (569,) be placed higher than this ; for fo it will fall within the arteries, which have neither the faculty of fenfation nor of vo- luntary motion. It, therefore, follows, that the feat of the mind mult be where the nerve firft begins its for- mation or origin. 373. We come now to explain the manner In which the nerves become the organs of fenfe or motion ; which, as it lies hid in the ultimate elementary fabric of the medullary fibres, feems to be placed above the reach both of fenfe and reafon: but we fliall, notwith- Ilanding, endeavour to make this as plain as experi- ments will enable us. And firft, it is demonftrated, that the fenfation does not come through the mem- branes from the fentient organ to the brain, nor that motion is fent through the coverings from the brain in- to the mufcle. For the brain itfelf lies deeper than thefe membranes, and receives the impreffions of fenfe, and when hurt throws the mufcles into convulfions. More- over, it is certain, that the nerves arife from the medul- la of the brain ; the truth of which is manifeft to the eye in all the nerves of the brain, more efpeciaily in the ol- faCfory, optic, fourth and feventh pair of nerves, which continue their medullary fabric a long way before they put on the covering of the pia mater. 374. We mufl, therefore, next inquire into this me- dulla, what it is. It is a very foft pulp, harder in in- fers and foolilli animals; but every where fimilar to itfelf. It affeClSj however, to be formed into fibres, or parallel Chap. XL BRAIN and NERVES. i8j parallel threads, lying upon one another lengthwife. That the coinpofition of it is fibrous, appears from in- numerable arguments ; more efpecially to the eye in the corpus callofum, in the ftriatum, and thalami of the optic nerves ; but (till more evidently in the brains of filh, and efpecially in their thalami optici. Again, that the fibres of the brain are continuous with thofe of the nerves, fo as to form one extended and open conti- nuation, appears, by obfervation, very evidently in the feventh, fourth, and fifth pair of nerves. There is a great deal of oil in the medulla, upwards of a tenth part of its whole weight. 375. But here a controverfy begins concerning the nature of this fibril, which, with others of the like kind, compofes the fubftance of the medulla and of the nerves. That this is a mere folid thread, and only watered by a vapour exhaling into the cellular fabric which fur- rounds the nervous fibres, has been aflerted by many of the moderns ; but that, when it is flruck by a fen- fible body, a vibration is excited, which is then con- veyed to the brain. 376. But the phenomena of wounded nerves will not allow us to imagine the nervous fibres to be folid. For if an irritated nerve is lhaken, (and that happens af- ter the manner of an elaflic chord, which trembles when it is taken hold of,) the nerve ought to be made of hard fibres, and tied by their extremities to hard bo- dies : they ought alfo to be tenfe ; for neither foft chords, nor fuch as are not tenfe, or fuch as are not well faften- cd, are ever obferved to tremulate. But all the nerves, at their origin, are medullary, and very foft, and ex- ceedingly far from any kind of tenfion : where they pafs through channels where they are well guarded, they retain the fame foft texture, and are not covered with membranes, as in the intercoftal nerves and the fe- cond nerves of the fifth pair ; fome alfo are foft through- out their whole length, whatever fize they may be of : for example, the foft olfaftory and acoufuc nerves, from which we would moll readily expect a tremor j as in the i 84 brain and nerves. Chap. XL the cafe of found. Agafn, though the nerves are hard, they are foftened in the vifcera, mufcles, and fenforia, before they exert their operations. Therefore, the nervous fibres cannot poflibly treinulate in an eladic manner, neither at their origin, nor where they are tenfe. But the fame, even in the proper and moit fa- vourable cafes, cannot treinulate ; becaufe, through their whole length, they are firmly tied to the folid parts by means of the cellular fabric ; for example, the nerves of the heart are tied to the great arteries, and to the pericardium. Finally, that the nerves are very far from all elaflicity, is demonftrated by experiments, in which the nerves, cut in two, neither fhorten nor draw back their divided ends to the folid parts ; but are ra- ther more elongated by their laxity, and expel their contained medulla in form of a protuberance. Again, the extreme foftnefs of the medulla in the brain, with all the phenomena of pain and convulfion, leave no room to fufpeft any fort of tenfion concerned in the effedts or operations produced by the nerves. 377. Add to this, that the force of an irritated nerve is never propagated upward, fo as to convulfe the mufcles that are feated above the place of irritation. This is a confequence altogether disagreeing with ela- fticity ; for an elaftic cord propagates its tremors every way, from the point of percuffion, to both extremi- ties. But if neither the phenomena of fenfe nor mo- tion can be explained from the nature of elafiicity, the onl)' probable fuppofition that remains is, that there is a liquor fent through the brain, which, defeending from thence through the nerves, flows out to all the extreme parts of the body ; the motion of which liquor, quick- ened by irritation, operates only according to the direc- tion in which it flows through the nerve : fo that con- vulfions cannot thereby afeend upwards, becaufe of the refiftance made by the frefli afflux of the fluid from the brain. But the fame liquid being put in motion in an organ of fenfe, can carry that fenfation upwards to the brain 5 Chap.XI. brain and nerves. 185 brain ; feeing it is refifted by no fenfitive torrent com- ing from the brain in a contrary direction. 378. It is therefore probable^ that the nervous fibres, and the medullary ones of the brain, which have the fame nature, are hollow. Nor is the objedlion which arifes from the fmallnefs of thefe tubes, not vifible by any microfcope, of any force againft the propofed ar- guments ; to which add the abfence of a fwelling in a tied nerve, which, in reality, is not fufficiently true with other arguments of the like kind, which indeed Iliow the weaknefs of thefenfes, but have not any vali- dity againfl the real exiftence of a juice or fpirit in the nerves. If they are tubes, it is very probable that they have their humours from the'arteries of the brain. 379. But concerning the nature of this nervous li- quid, there are many doubts. ’ Many of the moderns will have it to be extremely elallic, of an etherial or of an electrical matter ; but the more reafonable part malce it to be incompreflible and watery, but of a lym- phatic or albuminous nature. Indeed it is not to be de- nied, that we have many arguments againft admitting either of thefe opinions. An eleClrical matter is, in- deed, very powerful, and fit for motion ; but then it is not confinable within the nerves, fince it penetrates throughout the whole animal to which it is communi- cated, exerting its force upon the flefli and fat, as well as upon the nerves. But, in a living animal, the nerves only, or fuch parts as have nerves running through them, are affefted by irritation ; and, therefore, this li- quid muft be of a nature that will make it flow through, and be contained within the fmall pipes of the nerves. And a ligature on the nerve takes away fenfe and mo- tion, but could not ftop the motion of a torrent of elec- trical matter. 380. A watery and albuminous nature is common to moft of the juices in the human body, and may be therefore readily granted to the juice of the nerves j like the water which exhales into the ventricles of the brain from the fame veflels ; alfo, from the example of B b a iS 6 BRAIN AND NERVES. Chap. XL a gelatinous or lymphatic juice, which flows out in cut- ting through the brain in fifli, and the nerves of larger animals ; to which add, the tumour which arifes in tied nerves. But are thefe properties fufflcient to explain the wonderful force of convulfed nerves, obfervable in the dilTeftions of living animals, and even in the lefler infecls, with the great ftrength of mad and hyltcricalf people ? Whether or no is not this difficulty fomcwhat leffencd from the hydroffiatical experiments of attrac- tion in fmall tubes ; which, although it may explain the ffirength and motion, is nevertheiefs inconfiffient with the celerity ? 381. The nervous liquor then, which is the inftru- ment of fcnfe and motion, mufl; be exceedingly move- able, fo as to carry the imprellions of fenfe, or com- mands of the will, to the places of their deftination, without any remarkable delay : nor can it receive its motions only from the heart. Moreover, it is very thin and inviflble, and deliitute of all take and fmell ; yet reptTvable from the aliments. It is carefully to be di- ftinguilhed from that vifible, vifcid liquor exhaling from the veffels in the intervals between the nervous cords. 382. That this liquor moves through tubes rather than through a fpongy folid, we are perfuaded from its celerity, and the analogy of the whole body ; of which all the liquids, the fat excepted, run through their pro- per veffels, 383. Therefore, upon the whole, rt feems to be cer- tain, that, from the veffels of the cortex, a liquor is fe- parated into the hollow pipes of the medulla, which are continued w'ith the fmall tubes of the nerves, even to their foft, pulpy extremities, fo as to be the caufe both of fenfe and motion. But there will be a twofold mo- tion in that humour; the one flow and conffiant, from the heart ; the other not continual, but exceedingly fwift, wTich is excited either by fenfe, or any other caufe of motidn arifing in the brain. 384. The fame nerves moft: evidently prefide over both fenfe and motion ; as we are not allowed the two fvftems Chap. XL BRAIN and NERVES. 187 fyftems of motory nerves dlftin£l from fenfitive ones. If fenfe foraetimes remains after motion is deftroyed, this feems to be becaufe much more ftrength is requi- red for the latter. Dying people hear and fee, when in- capable of motion. 385. If it be aflced, What becomes of this nervous juice, which cannot but be feparated and diftributed in great abundance, from fo large a quantity of blood paffing the brain very fwiftly, in comparifon of the flower moving blood, from whence the milk is fepa- rated in the bread:, and the urine in the lefler renal artery, or by a comparifon with the mefentei'ic artery ? It may be anfwered, It -exhales probably through the cutaneous nerves ; the laflitude both with refpedt to fenfe and motion, which may be overcome by fpiritu- ous medicines, fhews that this liquid may be both loft and repaired. Many have judged, that it alfo exhales into the various cavities of the body ; as that of the ftomach, and inteftines. We may exped: fome part of it to be reforbed, that the nobleft humour of the body may not be too quickly diflipated. That it nouriflies the body, is incredible : it is too moveable to expedt adhefion from it; that is the oflice of a flow and vifcid hu- mour. 386. But then, what is the defign of fo many protu- berances in the brain ? what are the particular ufes of the ventricles, nates, and teftes ; with the diftindtion of the brain from the cerebellum; and the communication betwixt one fide of the brain, cerebellum, and fpinal medulla, with their oppofite fides, by fo many tranf- verfe bundles of fibres ? 387. The ventricles feem to be made of neceffary confequence, and towards the greater ufe and diftinc- tion of the parts. And that the corpora ftriata or tha- lami might keep their medullary parts from cohering one to another, it was neceffary for a vapour to be poured betwixt them ; and the fame is true with re- gard to the brain and cerebellum. Perhaps, likewife, she neceflity of adminiftring a degree of warmth to the B b 2 clofe l88 BRAIN AND NERVES. Chap. XI. clofe medulla of the brain may be one reafon for thefe cavities, by which the arteries enter, and are diitribu- ted in great numbers. Perhaps alfo it was proper, that, in the inmoft parts of the brain, fmall veffels only, with- out any large ones, (hould enter. We may alfo fufpect, that the foftnefs of the fibres of the brain requires fhort- nefs, in order to fuftain their own weight. 388. The ufes of mod of the protuberances we are rot acquainted with, but have them yet to learn from difeafes, and from anatomical experiments made on ani- mals having a brain like that of mankind.. But, in thefe refpefts, we have little hopes of fuccefs, in parts that are fo fmall, fo deeply, and fo difficultly fituated, and hardly ever to be approached but by a wound foon fatal. Whether thefe parts are fo many diftincl pro- vinces in which our ideas are ftpred up, and w'hether this be confirmed by the protuberant thalami of the op- tic nerve, are indeed queftions. But then mod of thefe protuberances fend out no nerves at all. 389. As to the internal communication of one part with the other by drim or duels; that feems to conduce to the advantage of motion, and probably of fenfe like- wife. Some of thefe communications join the brain with the cerebellum ; others join the fpinal medulla with the nerves of the brain itfelf, as in the acceffory nerve ; and mod of them join the right and left parts together, as in the anterior commixture (345.), and in the tw’o poderior (350.), in that of the corpus callofum (343.), in the driae betwixt a procefs of the cerebellum and tedes (354.); to w'hich add the medullary crofs- bars in the medulla oblongata and fpinalis (:?55.) For, from this drudlure, it feems inanifedly to follow, as well as from numberlefs experiments and obfervations, that, W'hen the right fide of the brain is injured, all the nerves, which belong on the contrary to the left fide of the body become difeafed or paralytic, and the reverfe. Moreover, by this contrivance, nature feems to have provided, that, in whatever part of the brain any injury may happen, the nerve that arifes from thence is, by Chap. XI. BRAIN and NERVES. this means, not always deprived of its ufe. For if the faid nerve receives its fibres by communicating bundles, as well from the oppofite as from its own hemifphere of the brain, its office may, in fome meafure, be conti- nued entire by the fibres which it receives from the oppofite fide, even after thofe of its own fide are de- flroyed. Accordingly we have numberlefs inflances of wounds, and with a confiderable lofs of fubftance from the brain, which yet have not been followed with in- jury to any nerve, or to any of the mental faculties. Many other lefs inequalities, ftripes, protuberances, and nerve-like iinpreffions, appear in the brain from mecha- nical necefiity, with the pulfation of the veffels, and the prelTure or figure of the continuous incumbent parts. 390. We have before declared, that the nerves arc -the organs of fcnfe and motion ; we- fhal! therefore proceed firfl to explain that motion before we defcribe the organs of fenfe ; becaufe it is more fimple, uniform, and perpetually exercifed, even in the fetus, before any of the fenfes. CHAP. xn. Of Muscular Motion. 391. ^ I HE organ of motion in the human body is X not fingle. And firfl, in every animal and vegetable fibre, alfo in hair, feathers, in membranes, the cellular texture, and in the humid mufcular fibre j again, in animal and vegetable gluten; there is a con- traflile power, which both refifls the lengthening out of its fubftance, and, when the extending power is ta- ken away, reftores the fibre, to its former fize; nor does this power ever ceafe endeavouring to bring the elementary particles into the clofeft contadl the mecha- nifm of the part can admit. After death, even for many days, it does the fame, fo that the fibres of a dir vided mufde contrafl towards each extremity, fo as to leave 190 MUSCULAR MOTION. Chap. XII. leave a wide gap in the middle. An artery, when cut, iikewife contradhs itfelf in length. 392, I call this force becaufe it continues to be efficacious after death, and fo is different from the powers of life. In the living animal indeed it is forne- what briflcer : for, both from cold and fear, the Ikin is moved, fo that it grows harder, and has its papillae erected, and along with this hardnefs contracts itfelf in length. Again, the cellular fibres are animated with this perpetual nifus to fnorten themfelves, and always tend to their own'contraftion. Hence, when the Ikin or any other membrane is extended, as foon as the caufe of extenfion is taken off, it returns by a gentle effort to its former ffiortnefs. But it even fomewhat refills the attempt to perpetual dillention ; and by a gentle but continual acceffion of its ovm elements, pro- pels the contained fat or water, or otiier bodies acci- dentally introduced. The fame power alfo feems to limit the excretion of vapour ; for the fibres and plates of the cellular texture being preternaturaJly relaxed, an immenfe quantity either of fat or of wmtery humour is depofited in that texture. And this debility feems to be the principal caufe of a true drcpfy. The fame caufe being always efficacious, and at work in the heart, joints, and every w’here throughout the body of the embryo, brings into nearer contadl the arteries, auricles, and ventricles ; produces flexures ; and contracts the heart, when in a manner diffolved, into a cone. The fame, by an unknown or hidden power, feems to form the lhape of molt parts of the human body ; and while it expels the gluten received into the cells, brings the terreftrial particles nearer to one another, and gives the proper folidity, curvature, and fituation, to the dif- ferent parts. 393. It is the nature of this power to aft continual- ly by a gentle but uninterrupted eftort. It is common for it alfo to be excited by poifons, in every membrane, fibre, and cellular texture ; but never by cutting or punfturing with an iron inllrument. Thefe are the knowm Chap. XII. MUSCULAR MOtlON. known properties of the red mufcular fibre. The ftrudtureof this fibre, then, it is nowneceffary for us to confider. 39.^. By the name of mufcular .fibres in the human body, we call bundles of reddifii -coloured threadsj which perform all the motions of which we are fenfible. When many of thefe 'fibres are collected together, and appear more evidently red, they are called a mufcle. The extreme fimplicity of the fabric in thefe parts has been the caufe of the obfcurity that prevails in under- ftanding how a fmall, foft, flefiiy portion can produce fuch flrong and ample motions as we fee in man, but more efpecially in the cruftaceous infects. 395. In every mufcle we meet with long foft threads or fibres, fomewhat elaftic or extenfible, and almoft conllantly difpofed parallel with each other ; and thefe, being furrounded with a good deal of cellular fubftance, are by that fattened together into little bundles. Thofe bundles, called lacertuli, are again tied together into larger bundles, by a more loofe cellular net- work, which contains fome fat ; and betwixt thefe we conllantly perceive membranous partitions and ftripes of the cel- lular fubftance, removing them farther from each o- ther, till at laft a number of them, combined together in a pofture either parallel or inclined, are furrounded with a more thin and denfe cellular membrane, conti- nuous with that of their partitions ; and this being a- gain furrounded by a thicker plate of the cellular fub- ftance, externally parts the whole from the adjacent flelh, and gives it the denomination of a fingle or entire mufcle. In every one of thefe threads there appears a lelfer feries of filaments, which, by oblique extremities, are cemented to others of the fame kind, forming toge- ther a larger fibre. 396. The generality of the mufcles, but more efpe- cially thofe which are inferred into the bones, and fuch as are prefled ftrongly by other flefhy incumbent parts, do not confift of fibres altogether of one kind. For the fielhy fibres (395 •)? being collefled together, caufe the 192 MUSCULAR MOTION. Chap. XII. the mufcle to be thicker in the middle, which is called its belly : and the fame fibres, degenerating by degrees obliquely at each end of the mufcle into a more fiender, hard, and fliining fubllance of a filver colour, in which, meeting clofer together, the . cellular fubftance inter- pofed is thinner, Ihorter, and painted with fewer vef- fels ; they then become indolent and difficultly irritable, and receive the denomination of a tendon, by being col- lected together into a round fiender bundle ; or clfc, if it expands into a broad flat furface, it is called an apo- neurofis. The cellular texture which covers the whole tendon is called its vagina or fheath, and refembles the coat of a mufcle. For that the flefhy fibres truly change into fuch as are tendinous, is evident from comparing a fetus (in which there are very few tendons) wdth a child of fome years growth, in which there are many more ; and both with an adult or old perfon, in which are the greatefl number. Mufcles, which are not inferted in- to any of the bones, have commonly no tendons, as the fphinCers and mufcular membranes of the vifeera and vefiels. But thofe commonly end in long tendons, which are required to pafs round the joints and heads of the bones, to be inferted in thofe extremiities w’hich are more moveable. In a fetus the mufcles are evi- dently inferted into the periofteum only ; but in adults, w'here the periofleum is more clofely joined with the bone itfelf, the tendons, being confufed with the peri- ofleum, pafs together with that even into the foveoli of the bone. 397. The tendinous fibres indeed often lie in a flraight line with the flefliy ones, and are as it were a continuation of them. But it is not at all rare for the flefliy fibres to be obliquely inclined to the tendon, and to adhere to it, as the tendon itfelf grows thicker in its progrefs by continually receiving new fibres. This is called a tendinous mufcle. Other tendons lie in the middle- betwixt two plates of fibres, forming an obtufe angle with one another, at irregular diflances, in their defeent. There are inflances of numerous tendons pennated Chai>. XII. MUSCULAR MOtlOJ^. 19^ pennated in different places formed into one mufele. There are alfo other methods by which the tendinous ftbres are joined with the flefliy ones. gp8. Within the cellular tunic that furrounds the fibres, the arteries and veins are fubdivided into net- works, which commonly form right angles, run in com- pany, and moftly contiguous with each other ; and from the fmaller of thefe veffels a vapour is exhaled into the thinner cellular fubftance, as the fat is alfotransfufed into the thicker cellular fubftance ; from whence again they are both abforbed. The lymphatic veffels, which run be- twixt the mufcles of the tongue, with thofe of the neck, face, and limbs, are difficultly demonftrated. But there are alfo nerves more numerous than in other parts, di- ftributed together with the blood-veffels throughout the cellular fabric of the mufele ; which nerves, however, depofite their harder covering, and become foft, and difappear before they can be traced to their ultimate extremities. Thofe enter the mufele in many parts, without keeping to the fame place or fituation. In the tendons they cannot be demonftrated. Nor are there any nervous fibres invefting the mufcular bundles or portions fo as to conftringe them ; for they, who have given fuch a defeription, have feen nothing but the cellular fubftance. 399. The fabric of the leaft, which are as the ele- ments of a mufele, being inveftigated by the microfeope in man and other animals, has always appeared fimilar to the fabric of the larger fibres ; nor do they yield any other appearance, upon which we can rely, than that of the leaft threads joined one to the other by the in- termediate cellular fubftance. There is, therefore, no foundation here for a feries of veficles, nor for a chain of rhombs. It may be afked, whether thefe fibres are hollow, whether they are continued with the arteries, or whether the difference betwixt mufcular and tendi- nous fibres lies in the latter being rendered more denfe and beat clofer together by an expulfion of the fluids ? That thefe are not probable, appears from the minute- C c nefs 194 MUSCULAR MOTION- Chap. XIL nefs of the fibres, which are found lefs than the red- blood globules, and from the whitenefs of a mufcle af- ter the blood is walhed out of it ; to which add the phy- fiological reafons following, (41 1 .) And, in general, more ftrength may be expeSed from a folid fibre. 400. A mufcle therefore is endowed at lead with a threefold force. Firft, the dead one, in common to it with other animal fibres. Another, which we have call- ed the vis infita^ and which has different phenomena from the former. For it is more proper to life, and the firft hours after death, and difappears much fooner than the dead one. Again, in moft cafes, it afts by alternate ofcillatioris ; fo that, being driven hither and thither, it fometimes contrails the mufcle towards the middle : fometimes again it extends the mufcle from the middle towards the extremities, and fometimes alfo it has a rei- terated motion. Moreover, it is manifeftly quicker, and performs the greateft motions ; the dead force, only fuch as are finall and not eafily obferved. It is excited both by the pricking of an iron inftrument, and in the hollow mufcles by inflated air, by water, and every kind of acrimony, but moft powerfully of all by a tor- rent of eleftrical matter. Laftly, it is proper to the mufcular fibre, and is found in no other part of the human body with the qualities abovementioned. But we muft give a more particular explication of its phe- nomena. 401. It is natural to every mufcle to fhorten itfelf, by drawing the extremities towards its belly or middle. But to difeover the moving power of a mufcle from the fabric which we have deferibed, it will be of ufe to confider the appearances obfervable in the mufcular contra( 3 ;ion. Every mufcle then becomes fhorter and broader in its action. But this contraction of its length is various ; in fome more, in others lefs ; and is very confiderable, for example, in fome of the fphinfters, in- fomuch that they appear to be contracted more than one third of their extent, though this computation be taken from an erroneous hypothefis. 402. The Chap. XIL MUSCULAR MOTION. ip5 402. The inteftines are exceedingly tenacious of their vis infita, as they continue to contradl themfelves long after they are taken out of the body, and even af- ter they are cold. The heart is even more tenacious thart thefe, if you confider all things ; as is moft evident in a young chicken, and in cold animals. Different mufcles are beft excited into adlion by different flimu- li ; as the bladder by urine, the heart by the blood, and the inteftines by air. Though the nerves are removed, or the conne< 9 :ion made by them between the mufcles and the brain cut off, the mufcles lofe but little of their irritable nature. It appears alfo from tbe example of polypi and other infeds, that the fame irritable difpofi- tion extends very widely through the animal fibres. Thefe creatures have neither brain nor nerves, yet are exceedingly impatient of ftimulus, Laftly, we may ga- ther this from the affinity of plants ; of which very many flowers and leaves open or contrad according to the various degrees of heat and cold, feme even very quick- ly, fo that they are nothing inferior in this refped to animals. Neither does this depend upon weight, at- tradion, or elaftlcity, feeing it is feated in a foft fibre, and vanifhes when the fame grows hard. 403. But that the caufe of motion is conveyed thro* the nerves into the mufcles, is certain from the experi- ments before-mentioned (367. et feq.) For the nerve a- lone has any feeling ; this alone carries the commands of the foul ; and of thefe commands there is neither intima- tion nor perception in that part whofe nerve is either tied or cut, or which has no nerve. Moreover, on irritating the nerve or fpinal marrow, even in a dead animal, the mufcle or mufcles which have nervous branches from thofe parts are moft vehemently convulfed. When the nerve of any mufcle is cut or tied, or the bafis of the fpinal marrow compreffed, or that part of the brain from whence the nerve has its origin, the mufcle be- eomes paralytic, and languiffies, and cannot by any force be recalled into adion fimilar to the vital one. But if the ligature be taken off from the nerve, the force C c 2 by 196 MUSCULAR MOTION. Chap. XII. by which the mufcle is put into action is again reco- vered by it. The nerve being irritated below the place where it is cut, the mufcle to which that nerve goes is contraded. This appears from numerous ex- periments, efpecially thofe made on the phrenic and recurrent nerves. 404. This force is not the fame with the vis infita. The former comes to the mufcle from without ; where- as the other refides conflantly in the mufcle itfelf. The nervous power ceafes when life is deftroyed j after which the other, from certain experiments, appears to remain a long time : it is alfo fuppreffed by tying a ligature upon the nerve, by hurting the brain, or by drinking opium. The vis infita lulfers nothing from all thefe ; it remains alter the nerve is tied ; and continues in the inteftincs though taken out of the body, and cut in pieces; it appears with great flrength in fuch animals as are defli- t'lte of brain : that part of the body is moved which has no feeling ; and the parts of the body feel which are without motion. The will excites and removes the ner- vous power, but has no power over the vis infita. 405. In the motion of the mufdes, whether owing to the vis infita or the nervous power, the fibres are contracted towards the middle of its belly, and recede from one another outwards : they are alfo diverfified with various tranfverfe wrinkles : the whole mufcle al- fo becomes Ihorter, and draws its extremities towards the middle ; hence it draws towards each other thofe parts with which it was connedled, in the reciprocal ra- tio of their flrength ; the mufcle alfo fwells by its con- tradion, becoming hard at the fame time, and as it were increafes its circumference on every fide. I have never obferved it to turn pale. Whether on the whole it is increafed in bulk, or acquires more in breadth than it lofes in length, is difficult to be known. It draws al- ter it the tendons, which are obfequious to its motions, though of themfelves neither moveable nor irritable. The whole mufcle is alfo capable of being moved at once, or only a part of it : if one extremity is fixed to an Chap. XII. MUSCULAR MOTION. 197 an immoveable part, that only , is moved which is capable of yielding. z}o6. If it be demanded, Whether the arteries' con- duce any thing to mufcular motion ? and whether the palfy, which falls upon the lower limbs after a ligature upon the aorta, be not an argument thereof? we an- fwer, Not at all, further than as they conduce to the integrity of a raufde, or to. the, confervation of the mu- tual ftrufture and. habit of the parts, which they fupply with vapour, fat, &c : for the irritation of an artery does not affe minifhed than increafed during its adion. Again, the inflation of rhomboidal chains in the fibres is e- qually repugnant to the celerity, to infpedion, and to anatomy ; they would alfo occafion an immenfe wafle of 198 MUSCULAR MOTION. Chap. XII. of ftrength, and after all render the mufcle but little fhorter. The nerves want that irritable nature which is obl’erved in the mufcular fibre. Finally, it is by no means demonftrable,that the fibres, from fo few nerves, can be fo munerous, or dillributed info many different tranfverfe direftions, with refpect to the mufcular threads, as thofe hypothefes require to be allowed. A complication of the nerves round the extremities or fi- bres, fo as to contract them by their elafficity, is found- ed upon a falfe ftrufture of the mufcular fibre, fuppo- fmg the nerves to be diftributed, where filaments of the cellular fubftance only can be demonllrated. More- over, the phenomena of animals which, having neither brain or nerves, are yet very apt for motion, apparent- ly demonlfrate the intrinfic fabric of the mufclcs to be fufficient for their motion, without other affiftance from the nerves. Other explanations, derived from fphe- rules full of air in the blood, fuppofe a falfe nature of that fluid ; namely, a repletion of it with elaftic air, of which it has none, (281.) The animal fpirits are not of the nature of an electric torrent. 408. If we may add any thing to thefe phenomena, you may fuppofe the nervous liquor to be ofa flimulating nature, by which means it forces the elementary par- ticles of the mufcular fibre to approach nearer to each other. The motive caufe which occafions the influx of the animal fpirits into the mufcle fo as to excite it into action, feems not to be the foul, but a law derived im- mediately from God. For animals newly born, or newly transformed, without any attempt, or exercife, know how to execute compound motions very difficult- ly to be defined by calculation. But the foul learns thofe things which it does, very flowly, iinperfecfly, and by making experiments. That mufcle then is con- trafted which in a given time receives more of the ner- vous fluid, whether that be occafioned by the will, or by fome irritating caufe arifing in the brain, or applied to the nerve. 409. But, tho’ you may conjedure the foul to be the caufe Chap.XIL muscular MOTION. 199 caufe of the nervous motion, you cannot do the fame with regard to that arifing trom the vis infita. The heart and inteftines, alfo the organs of generation, are governed by a vis infita, and by ftimuli. Thefe pov/ers do not arife from the will; nor are they lelfened, or ex- cited, or fuppreffcd, or changed by the fame. No cuf- tom nor art can make thefe organs fubjedl to the will, which have their motions from a vis infita ; nor can it be brought about, that they fliould obey the commands of the foul, like attendants on voluntary motion. It is fo certain that motion is produced by the body alone, that we cannot even fufpeft any motion to arife from a fpiritual caufe, befides that which we fee is occafioned by the will ; and, even in that motion which is occa- fioned by the will, a ftimulus will occafion the greateft exertions when the mind is very unwilling. 410. There feems to be this difference between the mufcles obeying the will, and thofe which are gover- ned by a vis infita ; namely, that the latter, being more irritable, are very eafily excited into motion by a gentle ftimulus; as for inftance, the heart and inteftines; which organs are moft manifeftly, and greatly, and conftantly, irritable. On the other hand, the mufcles which obey the will, are neither endowed with fo great nor fo durable a power of this kind. Hence, they ei- ther ftand in need of the power of the will, or a ftronger ftimulus ; by which, indeed, when they are excited, even thefe are animated to motion againft the will. Thus it happens, that, in apoplexies, the mufcles which obey the will, languifh, and become paralytic, as being deftitute of all influx from the brain ; while the vital mufcles, having no occafion for the operation of the brain, continue to be excited into contraftion by their ftimuli ; the heart by the blood, and the inteftines by the air and aliments. 411. The ftrength of this adion in the mufcles is ve- ry confiderable in all perfons, but more efpecially in thofe who are phrenetic, and fome who are called ftrong men ; fince frequently, with the ufe of a few mufcles only. 200 MUSCULAR MOTION. Chap. XIL only, they will eafily raife a weight equal to, or much greater than, that of the whole human body itfeif. For even in one who is in his fenfes, very {lender mufoles fuffice to elevate 200 or 300 pounds. The mufcles of the back will even fuftain 3000. Notwithftanding this, we fee, that much the greater part of the force or power exerted by a mufcle is always loil without pro- ducing any vifiblc efFed;. For all the mufcles are in- ferted nearer the point or centre of motion, than the weights they are applied to ; and therefore their aclion is weaker, in the fame proportion as they move a Ihor- ter part of the lever, than that to which the weight is applied. Moreover, in moft of the bones, efpecially thofe of the limbs, the mufcles are inferred at very acute angles; whence again the effect which a mufcle exerts in aefion, is proportionably lefs as the fine of the angle intercepted betwixt the bone and the mufcle is lefs than the whole fine. Again, the middle part of all mufeu- lar force is loft, becaufe it may be reckoned as a cord extended, and drawing ah oppofite weight to its fixed point. Again, many of the mufcles are feated in the angle of two bones, from one of which arifing they move the other ; and therefore, that bone being moved, they are bent, and of courfe, like an inflectsd cord, re- quire a new force to extend, them. Many of them pafs over certain joints, each of which they bend in fome de- gree, wkereby a lefs part of their remaining force goes to bend the joint to which they are particularly defti- ned. The flefliy fibres themfelves of the mufcles fre- quently intercept angles with the tendon in wdiich they terminate ; from whence a great part of their force is loft, as much as is equal to the difference or deviation betwixt the fine of the angle of their infertion and the whole fine. Finally, the mufcles move their oppofed weights with the greateft velocity and expedition, fo as not only to overcome the equilibrium, but likewife to add a confiderable celerity to the weight. 412. Ail thefe Ioffes of power being computed, make it evident, that the force exerted by mufcles in their con- 2Qi Chap. XII. MUSCULAR MOTION. contraction, is exceeding great beyond any mechanical ratio or proportion whatever ; fmce the effedl is fcarce ia of the whole force exerted by the mufcle, and yet only a ftnall number of thefe mufcles, weighing but a few pounds, are able not only to raife fome thoufands of pounds, but alio with a confiderable celerity. Nor is this to be reputed any defeft of wifdom in the Crea- tor. For all thofe Ioffes of power were neceffary to- wards a juft fymmetry or proportion of the parts, with the various motions and celerities required by the muf- cles to afl in different diredtions ; all which have no fliare in the compofition of engines mechanically. But we may, however, conclude from hence, that the adlion of the nervous or animal fluid is very powerful, fmce, in an engine fo fniall, it can exert a force equal to fome thoufand pounds for a confiderable time, or even for many days together ; nor does this feem to be otherwife explainable, than by the incredible celerity by which the influx of this fluid obeys the command of the will. But how, or from whence, it acquires fuch a velocity, is not in our power to fay ; it is fufficient, that we know the laws of its motion are fuch, that a given adfion of the will produces a new and determinate celerity in the nervous fluid or juice. 413. The eafy and fudden relaxations of mufcles in, their motion are aflifted by the adtions of their antago- nijl mufcles. Namely, in all parts of the body every mufcle is counterpoifed by fome weight, elaflicity, an oppofite mufcle, or a humour adting againfl the cavity of a mufcle, by which it is expelled. This caufe, which is a vis infita, continually operates as long as the mufcle adls; and fo foon as the additional celerity derived from the brain abates, it reflores the limb or other part im- mediately to its former eafy flate, in which there is an equilibrium betwixt the mufcle and its oppofmg caufe. Whenever the antagonift power is removed from the mufcle, there are none of them but muff contradf, ex- tending their oppofites, by which the diflended nerves excite an uneafy fenfe, and caufe a ftronger endeavour D d towards 202 MUSCULAR MOTION. Chap. XII, towards recovering the equilibrium. Hence one of the flexor mufcles being cut in two, the extenfor operates even in a dead body ; and the reverfe. 414. But there are other means, by which the mo- tions of the mufcles are rendered more fafe, certain, and eafy. The large long mufcles, by which the greater motions of flexure are performed, being included in tendinous capfules or cafes, drawn and tightened by o- ther mufcles, are thus fecured and ftrengthened ; for fo the mufcle remains prelTed againfl: the bone, in a ftatc of contraftion, all the time that the limb is bent, and avoids a confiderable lofs of its power. But the long tendons, which are incurvated or extended over joints in their motion, are received and confined by peculiar bands, which retain them within their flippery channels, and keep them from flipping out under the fkin ; which diflocation of the tendon, whenever it happens, is at- tended with a cramp of the mufcle, fevere pain, arid lofs of motion. The fame kind of guidance or direftion is received by fomc of the mufcles, which perforate others in their courfe. In other parts, the tendons are cither carried round certain eminences of the bone, in order that they may be inferted at greater angles into the bone which they inove; or elfe they are inferted into another bone, from whence a different tendon defeends under a larger angle into the bone to be moved. In other parts, the mufcles which are derived from conve- nient fituations, have their tendons carried round in a contrary diredlion by nature, fo that they pafs into the part to be moved as it were round a pully. Nature has likewife furrounded the mufcles on all fides with fat, which is fpread alfo betwixt their bundles of fibres and the fmall fibres themfelves which lie contiguous toge- ther ; which fat, being prefled out by the turgefcencc of the mufcles and fibres, renders them foft, flexible, flippery, and fit for motion. 4 1 6. Moreover, the pow’er and action of one mufcle is determined by the co-operations or oppofitions of o- thers, which ferve either to hold firm feme part from whence Chap. XII. MUSCULAR MOTION. 203 whence the mufcle arifes, or to bend it together with the mufcle, or elfe to change its aiftion from the per- pendicular to the diagonal, by concurring to affift its force at the fame time. The mufcles alfo affiil one a- nother, even thofe which are feparated at a confider- able diftance, the firfl keeping the bone firm which is not to be moved, and out of which the fecond arlfe. Therefore, the adlion of no one mufcle can be under- ftood from confidering it alone ; but all the others mufl likewife be brought into the confideration, which are either inferted into the mufcle itfelf, or into any of the parts to which the faid mufcle adheres. 417. By thefe mufcles, varioufly confpiring and op- pofing each other, are performed walking, (landing, flexion, extenfion, deglutition, and all the other ge- ftures and offices of the feveral parts in the living body. But the mufcles have likewife fome common or public actions, by which they are of ufe to the whole animal. They haften the return of the venous blood, by pfefs- ing it out from the veins both of the mufcles them- felves as well as of the veins which lie betwixt them ; for the blood in thefe velTels, diftributed betwixt the turgid bundles of a contradled mufcle, is, by the valves, determined towards the heart only : they likewife re- turn the fat to the blood ; and (hake, grind, or denfi- fy the arterial blood, and return it quicker to the lungs. Again, in the liver, mefentery, womb, &c, they promote the courfe of the contained blood, bile, and other juices, fo as to leffen the danger of their ftag- nation : they ferve alfo to incrfeafe the (Irength of the (tomach, by adding their own (Irength to it, whereby digeftion is prorqoted; infomuch that ail fedentary and inadive courfes of life are contrary to nature, and pave the way to difeafes from a (lagnation of the humours, or from a corruption or crudity of the aliments. The large mufcles, which are generally placed round any of the cavities of the body, propel the blood con- tained in that cavity, and prefs it towards the heart. But by too much exercife or ai^ion, the mufcles D d 2 them- 204 MUSCULAR MOTION. Chap. XII. themfelves grow hard and tendinous on all fides ; render the parts upon which they are incumbent cartilaginous, or elfe change thofe which are membranous into a bony nature ; increafe the roughnefs, protuberances, and procefles, of the bones which lie next to them, and excavate their flat parts ; dilate the cells feated in the diploe; and bend the bones towards thefe parts. 418. The mufcle which the (limulus has ceafed to irritate, or for the action of which the mind has no oc- cafion, is relaxed, and grows foft ; its wrinkles are fill- ed up, and grow plain ; its fibres are rendered longer, receding from the middle towards the fixed extremi- ties ; and its fwelling falls. Whatever is the caufe of additional contraftion is then taken away ; but that re- mains without which the mufcle never is as long as it is alive. Nor is this the work of an antagonifl: mufcle, although it may be aflifled by it. It may be alked. What becomes of the fpirit that is fent forth from the brain ? A part of it perhaps exhales ; I fufped a part to adhere to the fibre ; and that thus it happens that the mufcles grow ftrong with exercife, and their brawny parts become thicker. CHAP. XIII. '' Of the Senfe ^ T o u c H. 4^9* T^UE other oflice of the brain and nerves is X to perceive ; that is, to fuflPer a change from the a£tions or impreflions of external bodies, and there- by excite other correfponding changes or reprefcnta- tions in the mind. We fhall, therefore, fir ft lead our examination to each of the fenfes in particular; and then confider what is common to all of them, with the changes which follow from thence in the common fenfory and in the mind. 4’o. The fenfe of touch is underftood in a twofold manner. For, by this term, in general, we call all changes Chap. XIII. TOUCH. 205 changes of the nerves, arifing from heat, cold, rough- nefs, fmoothnefs, weight,, moifture, drynefs, or other affections of external bodies, in whatever part or organ they are applied to caufe a change. In this fenfe, the touch is afcribed to almoft all parts of the human bo- dy, tofome more, toothers lefs; as in different places of the body the nerves are more numerous and bare, or covered with more tender membranes ; and thus even pain, pleafure, hunger, third, anguifh, itching, and the other fenfations, belong to the fenfe of feeling. 42 i. But, in a fomewhat different and more proper acceptation, the fenfe of touch is faid to be the change arifing in the mind from external bodies applied to the fkin, more efpecially at the ends of the fingers. For, by the fingers, we more accurately diftinguifli the tan- gible qualities of things than by other parts of our body. 422. Indeed, this fenfe does not eafily diftinguifli any particles by the fkin, which it does not touch. But fince the touch is more peculiarly afcribed to the cuta- neous papillae, therefore the ftrudure of the fkin is to be firft defcribed. That part, then, which is called the true jk'in, is compofed of a thick cellular net-work, whofe fibres and plates are clofely compared and in- terwove together in an intricate manner, which renders }t porous, and capable of contradling or dilating to a furprifmg degree. Its ftrata, when expofed to the air by turning up the epidermis, become more clofely compared together ; the fame is infenfibly relaxed to- wards fat, and is refolved into a fofter cellular texture. It is more tender in fome places, and in others more hard. Within this fubftance run many fmall arteries, which come from the fubcutaneous ones, which, tho’ neither large nor of a very great length, are yet nu- merous in fome parts of the fkin, which look red, as in the cheeks ; but in other parts they are fewer in number. The veins arife in great numbers from the fubcutaneous net-work, and the nerves likewife in the fkin are very numerous ; but they vanifh fo fuddenly, that it is very difficult to trace the ultimate extremities of 2o6 touch. Chap. XIII. of them. Betwixt the (kin and mufcles is placed the cellular fabric, into which the fkin is infenfibly refolved, in molt parts repleniflied with fat, the little eminences of which prefs upon the fmall hollows of the fkin ; but in fome, as the penis, red part of the lips, See. it is de- ftitute of fat. There are very few parts in the body of man where the fkin is immediately joined to the muf- cular fibres without any feparatton by fat or cellular fubflance ; for, though the dartos of the teflide has no mufcular fibres, it is not without the cellular fubflance. There are fome places, indeed, where tendinous fibres are inferted into the fkin ; as in the neck, in the palms of the hands, and foies of the feet. 423. Throughout the whole furface of the fkin in/ tnofl parts of the body, but with fome difficulty, you will find it to have a rough appearance after the cuticle is taken off ; but in the human body thefe are fo ob- tufe, that, unlefs you underfland them to be very mi- nute granulations, they are raifed hardly any vifible height above the fkin. But in the ends of the fingers there are larger round fapillez feated in cavities of the cuticle, and receiving nerves very difficultly feen ; namely, a little mount or protuberance formed of fmall veffels, with one or more fmall nerves wrapped up to- gether in the cellular fubflance. Thefe, in the lips and glans penis, after long maceration, appear villous or down-like ; and are feen mofl evidently of all in the tongue, from the fabric of w'hich we conclude, by a- nalogy, with refped to the other cutaneous papillte. 424. Over the furface of the fkin is placed another covering, which is not fo liable to be injured by the air, and which coheres with the fubjacent fkin by an infi- nite number of fmall bloodlefs veffels, and by hairs which pafs through its fubflance. The outer furface of this covering, as it were of an horny fabric, is dry, infen- fible, and not fubjed to putrefadion ; but, being defli- tute of veffels and nerves, it appears in a particular manner wrinkled and fcaly, and is joined to the fkin by a kind of net-work. This is called the epidermis or cuticle^ TOUCH. Chap. XIII. 2C7 tuticle^ which is perforated by an infinite number of pores, fome larger for the fweat, and others fmaller for the perfpirable vapours, out of whofe duds, ex- panded and cemented by the interpofition of a con- denfed glue, the fubftance of the cuticle is probably compofed. By preffure or burning, the cuticle grows thicker, by the addition of new plates or fcales, form- ed betwixt the fldn and thofe which lie outermoft ; and this is called a callus. But even naturally, in Blacks, the cuticle has two diflind plates. 425. The inner furface of the cuticle is more foft and like a pulp, fomewhat like an half fluid or a con- creted mucus j whence, by macerating fome time in water, it feparates from the former, difficultly in Eu- ropeans, but eafily in the Blacks, where it is truly mem- branaceous, folid, and feparable, as in the palate of brutes. This furface of the cuticle lies incumbent on the fkin itfelf, whofe papillae, in thofe parts where they arc to be found, are received into the foft cuticular alveoli or fockets. This is commonly called rete Malpighianurrif although it be certain there are no perforations vifible through it, like thofe of a fieve. 426. That this reticular body is compofed of a hu- mour, tranfuding from the furface of the true fkin, feems very probable. As to the fabric of the cuticle itfelf, it is obfcure ; for fince it is both cafl off, or re- generated, infenfible, and deflitute of veflels, it does not feem to belong to the organical parts of the body. Whether is it the outer part of the Malpighian mucus (425.), coagulated and condenfed by the air and by preffure ; after being perforated with a number of ex- haling and inhaling duds, the mouths of which are cemented together by the interpofed condenfed glue ? and whether or not are we perfuaded to this opi- nion by the mucous expanfion upon the membrane of the tympanum ? to which add, the diffolution of it in water, obferved by the more eminent anatomifts ; which experiment is by others denied in the cuticle of Blacks. 427. More- 2 o8 touch. CHAp.Xm. 427. Moreover, to the hillory of the fKin belong the fimple glandules, which are feated in very many places under the (kin in the cellular fabric ; from whence perforating the Ikin by their excretory duct, they pour out a foft half fluid liniment. Other feba- ceous glandules, partly fimple and partly compound, generate a dry white liniment, of an harder confiltence in the face, but more oily in the groins and arm-pits, with which the fldn being anointed, fliines, and is de- fended both from the air and outward attrition. They are found feated in all parts of the body that are under a necefiity of being more immediately expofed to the air, as in the face, where there are a great number of the compound fort ; or wherever the fkin is liable to any great attrition, as in the arm-pits, nipples, groins, glans penis, nymphae, anus, and hams. They fre- quently fend out hairs. If it be afked. Whether thefe follicles are feated in all parts of the fkin ? we anfwer. That, although anatomy does not every where demon- ftrate them, yet it feems probable that they are in no part abfent, as may appear from the fordes collected about the whole furface of the body, feemingly of the febaceous kind. But there is another fort of liniment or oily ointment poured out upon the fkin from the fat itfelf, by its particular pores, without the intervention of glands (209.) ; and this more efpecially where the fkin is clothed with hair, as in the fcalp. 428. Again, both the hair^nd nails are appendages to the fkin. The former are fcattered over almoft the whole furface of the body, the palms of the hands and foies of the feet excepted ; in mofl parts fhort and fo't; but longer upon the head, mouth, cheeks, and chin, with the breafl in men ; alfo, upon the forepart of the limbs, in the arm-pits, groins, and pubes. They arifc from the cellular texture lying under the fivin, originat- ing from a little bulb which is membranous, flrong, vaf- cular, and of an oval fhape, and more lax towards the cellular texture, (and from this bafis the hairs are aug- mented by veffds)j in which little bulb another bulb Chap. Xlir. I? O U C H. 209 lies hid, at firfl; roundifb, but afterwards cylindrical, and furrounded with blood. In that fecond bulb lies the hair, laid over with a fat humour. The hair, with both its cylindrical fheaths, comes to the cutaneous hole, goes out through the fame paffage, and forces the epidermis into a fimilar flieath ; from whence the in- corruptibility of the hair : and then the cover cannot be feparated farther from the cortex ; but the filaments, and fpongy and cellular matter, are continued throughout the whole length of the hair. The hairs grow natu- rally in the cellular fubllance under the fkin ; but, by difeafe, they are fometimes formed within the fat of o- ther parts. They grow continually ; and are renewed again, after being cut, by a protrufion of their medul- lary fubftance from the fkin outward, under a produc- tion of the cuticle. When the hairs are deflitute of this medulla in old people, they dry up, fplit, and fall off. Their colour is from the juice, which fills the internal cellular texture. They feem to perfpire through their extremities, and poffibly throughout their whole fur- face ; as we may conclude from the conftant force of protrufion in their medulla, which, in the plica Poloni- ca, wants a boundary to terminate it. To which add, the luminous (freaks or rays that come out from the hairs of an animal eledlrified. The fubcutaneous fat, or oil, feems to follow, and tranfude through the medul- lary traft and pores of the hairs. 429. The nails are of the nature and fabric of the cuticle ; like which they are alfo infenfible, and renew- able after being cut or fallen off. They are found placed upon the backs of the ends of the fingers and toes, which they fupport, to make a due refiftance in the apprehenfioinof objects, having the nervous papil- lary bodies, that ferve the organ of touch, placed under their lower furface. They arife with a fquare root, in- termixed with the periofleum, a little before the laff joints, from betwixt the outer and inner flratum of the fkin ; and paffing on foft, go out by a lunar cleft in the external plate of the fkin, where the cuticle returns E e back. 210 TOUCH, Chap. XIII. back, and is partly laid over the outfide of the nail, to- gether with which it is extended forward as an outer covering. The nail itfelf is of a foft tender fabric where it firil; arifes, partly covered by the fkin ; but, by age and contadf with the air, it in time hardens into a folid, horny, and efailic body, compofed of long hair-like threads, cemented together by interpofed glue, and di- ftinguiflrable from each other by intervening fulci or furrows, by which one may be able to fplit them into a number of leffer orders. The nail thus formed, ex- tends itfelf to the extremity of the finger •, and is, in this traft, lined all along internally within its concave furface, by an expanfion of the true fkin, and fabjacent periofteum intermixed ; the filaments of which arife firfl fhort, and are afterwards continued of a greater length, till they become longeft of all at the extremity of the nail to which they cohere. Thefe are mofl inti- mately connected into the root of the nail. Over the , outer furface of the nail, fame part of the fkin is again at liberty, and lies under the nail, and diflinft from it,, and has its own epidermis. A furrowed net-work is interpofed betwixt the fkin and nail, which is alfo eafily feparable and foft, for the protection of the papillae ; from thence the furrows grow gradually harder, fo that at laft they can fcarce be diftinguiflied from the nail. The tendons do not reach quite fo far as the nail. 430. The cellular fubftance is v/ithout fat, e.xcept in a few places to allow a neceffary motion to the fkin. Where it is replcnilhed with the fat, it ferves to defend the warmth of internal parts from the cold air ; to ren- der the fkin moveable upon the mufcles ; to fill up the cavities betwixt the mufcles themfelves ; and to render the whole body white and uniform. The Ikin, cuticle, and its Malpighian mucus, ferve not only to limit the external bounds of the body every where ; but likewife, where they feem to be perforated, pafTing inward, they degenerate by degrees. For the cuticle is manifeflly extended into the anus, urethra, vagina, cornea of the eye, auditory paffage, mouth, and tongue ; nor is it wanting 2II Chap. XIII. TOUCH. ■wanting even in the ftomach itfelf and inteftines; al- though, by the perpetual warmth and moifture, its fa- bric be altered, and extended or relaxed into their vil- lous covering. Thus the true (Idn is continued into the internal fabric of the palate, tongue, pharynx, no- ftrils, vagina, &c. where it degenerates always into a white, thick, pulpy, commonly called nervous, coat of thofe parts. 431. What has been hitherto advanced, is fufficient to enable us to underftand the nature of touch. The papillte, feated in the larger winding ridges at the ends of the fingers, regularly difpofed in fpiral folds, are, by the attention of the mind, a little raifod or eredled ; as appears from frights or fliiverings ; as we fee in the nipples of women, in the handling of tangible obje£ls, and by light friftion ; whereby, receiving the impreflion of the objedl into their nervous fabric, it is thence con- veyed, by the trunks of the nerves, to the brain. This is what we call the touch, whereby we become fenfible chiefly of the roughnefs of objefts ; in which fome per- fons have fo fharp a fenfation, that they have been known to diflinguifh colours by touching the furface only. By this fenfation we perceive, heat, when it ex- ceeds in bodies the heat of our fingers ; and weight likewife, when it preflfes more than is ufual. Humidity we judge of by the prefence of water ; foftnefs, by a yielding of the obje£l ; hardnefs, from a yielding of the finger ; figure, from the limits or rough circumfcribed furface ; diftance, from a rude calculation or ellimate made by experience, to which the length of the arm ferves as a meafure : fo the touch ferves to corredl the miftakes of our other fenfes ; but yet it fometimes errs itfelf, and then the other fenfes fliew themfelves to be true guides, to the animal without that of touch. 432. The mucous body of Malpighius moderates the aftion of the taftile obje£l, and preferves the foftnefs and found ftate of the papilla. The cuticle excludes the air from withering and deflroying the fldn ; quali- fies the imprelfions of bodies, fo that they may be only , E e 2 fufficient 2t2 T O U C H. Chap. XIII. fuffident to afFed the touch, without caufing pain : and, therefore, when it is become too thick by ufe, the fenfe of feeling is either lofl. or leffened ; but if it be too thin and foft, the touch becomes painful. The hairs ferve to defend the cuticle from abrafion ; to preferve and in- creafe the heat ; to cover and conceal fome parts, and render the membranes of others irritable, which nature required to be guarded from the entrance of infects j and perhaps they may ferve to exhale fome ufelefs va- pours, or afford a palfage to the exhaling oil. The nails ferve to guard the touch, that the papillae and ends of the fingers may not be bent back by the refiftance of tangible objeds : at the fame time they increafe the power of apprehenfion, and affifl in the handling mi- nute objeds. In brute animals, they generally ferve as weapons of offence ; and might be of the fame ufe to man, if they were not cut off. 433. But thefe are not all the ufes of (he fkin. For one mofl important office of that covering is to exhale from the body a large quantity of humours and other matters to be carried off by the air. Ac- cordingly, the whole furface of the fkin fweats out a vapour by an infinite number of fmall arteries, either coiled up into papillae, or fpread on the fkin itfelf, which pafs out, and exhale through correfponding pores of the cuticle •, although the courfe or diredion of the veffels which pour out this vapour be changed in paffing from the fkin to the cuticle. Thefe exhaling veffels or arteries are eafily demonftrated by an injedion of wa- ter or fifh-glue into the arteries ; for then they fweat out from all parts of the flcin an infinite number of fmall drops, which being transfufed under the cuticle, ren- dered impervious by death, raife it up into a blifter. 434. In a living perfon, this exhalation is many ways demonflrable. A clean looking-glafs, placed againfl ^he warm and naked fkin, is quickly obfcured by the moifl vapour. In fubterraneous caverns, where the air is more denfe, it more plainly goes off into the ai. , from Chap. XIII. TOUCH. 213 from the whole furface of the body, in the form of a vifible and thick cloud. 435. Whenever the motion of the blood is increa- fed, while at the fame time the fkin is hot and relaxed, the fmall cutaneous pores, inftead of an invifible va- }X)ur, difcharge fweat, conhfting of minute, but vifible drops, which run together into larger drops by joining with others of the fame kind. But thofe parts chiefly are fubjecl to fweat which are hotteft ; that is to fay, where the fubcutaneous arteries are largeft, and have a greater adion from their refiftance, as in the head, breaft, and foldings of the fkin. The experiment be- fore mentioned (433.), together with the fimplicity of nature herfelf, joining with the vifible thicknefs or cloudinefs of the cutaneous and pulmonary exhalation (434.), fufficiently perfuades us, that the perfpirable matter and fweat are difcharged through one and the fame kind of vefTels, and differ only by the quantity and celerity of the matter. But together with the fweat is intermixed the humour of the febaceous glands (427.) and the fubcutaneous oil, which being more plentifully fecreted, and diluted with the arterial juice, flows out of an oily and yellow confiftence, and chiefly gives that fmell and colour to the fweat for which it is remark- able. Hence we find it more fetid in the arm-pits, groins, and other parts, where thofe glandules are moft numerous or abundant. Both blood and fmall fand have been known to proceed from the fkin along with the fweat. 436. Concerning the nature of perjpiration, we are to inquire by experiments, and by analogy with the pulmonary exhalation, which more frequently and a- bundantly perfpires a vaporous cloud of the fame kind, more efpecially vifible in a cold air. That what flies off from the body in this exhalation is chiefly water, appears from experiments, by which the breath, being condenfed in large veffels, forms into watery drops. Agreeable with this, we find the obfcuring vapour PQndenfed by a looking-glafs to be extremely fubtle, fo as 214 TOUCH. Chap. Xin. as "wholly to fly off* again from it ; and the fame is con- firmed by the obftrufted matter of perfpiration pafling off* by urine, or frequently changing into a diarrhoea ; and from the eafy paffage of warm liquors in the form of perfpiration by a hot air, or elfe by the urinary paf- fages in a cold air. The water of thefe vapours is chiefly from what we drink, but is in part fupplied from the inhalation of the (kin. Frequently, even the particular fmell of the aliments may be plainly percei- ved in the perfpiration ; and there is alfo an admixture of the eledrical matter in every perfon, but in fome it is more evidently lucid. 437. But that there are, befides water, fome volatile particles intermixed of an alkaline nature, is evident, as well from the nature of our blood, as the confider- able mifehiefs which follow from a retained perfpira- tion. This volatile alkaline matter arifes from the finer particles of the blood, attenuated by perpetual heat and triture, and changed into an acrimonious na- ture, Thefe afford the feent which is clofely followed by dogs, who would not know their mafters unlefs fome- thing of a particular nature perfpired from each perfon. 438. The quantity of our perfpiring moifture is ve- ry large, whether we confider the extent of the organ by which it is feparated, the abundance of vapours de- rived from the lungs only ; or barely take a review of the experiments made by Sanftorius, in which five pounds out of eight, but by other experiments in a colder country from fifty-fix to thirty ounces, of the food and drink taken into the body in a natural day,were found to fly off by perfpiration only, exclufive of any of the vi- fible difeharges, and without making any addition to the weight of the body; but from this weight you muff de- duce that of the faliva, mucus of the nofe, and fweat. But the cutaneous exhalation is even much larger than this ; fince it is not only throws off fuch a quantity of the indigefled food and drink, but likewife what is added to the blood by the way of inhalation (442.), which enter- ing, often in a very confiderable quantity, is thus again expelled. Chap.XIIL touch. 215 1 expelled. But different difpofitions of the air, and of the human body, caufe great variations in thofe mat- ters. In warm countries, in the fummer-months, and in young exercifed perfons, more goes off by tranfpi- ration from the body, and lefs by the urine. But in cold climates, during the temperate or winter feafons, in aged or inactive perfons, more goes off by the urine than by the infenfible difcharge. But in temperate countries, making a computation throughout the whole year, fomething more is perfpired than what pafles off” by urine ; and joining together all the experiments made in different countries, both excretions are almoff: alike. The difference of time after feeding does alfo in foine meafure vary the quantity tranfpired ; but in general it is moft copious at that time when the greater part of the digefted nourifhment is conveyed into the blood, and therewith attenuated fo as to be fit for ex- halation. It is naturally diminilhed in ffeep, even in the warmer climates j but it is increafed by the heat of bed-cloaths. 439. In general, a plentiful and uniform perfpira- tion, with ftrength of body, are good figns of health ; for whenever it abounds from too great weaknefs, it is obferved to do more mifehief than none at all, if the writings on that head are fufficiently to be depended on. It is thus a fign of health, becaufe it denotes a free pervious difpofition of the veflels difperfed through- out the whole body, together with a complete digeftion of the nourifllment, the. greater part of which is per- feflly attenuated into a vapour. When it is dlminifh- cd, it indicates either a conftriction of the Ikin, a weaknefs of the heart, or an imperfeft digeftion of the aliments. Perhaps in too great a perfpiration the nervous fpirits themfelves are evaporated. This dif- charge is, by moderate exercife, increafed to fix times that of an idle perfon, even to an half or whole pound in an hour, aided by ftrong and open veflels, by warm, watery, and vinous drinks, with animal food of an eafy digeftion, and a heavy, temperate, or m'oderately warm air. 2i6 TOUCH. Chap. Xin. air, affifteJ with joyful affections of the mind. The contrary of thefe either leffen or fupprefs the perfpi ra- tion ; as thick fkin, a inoift air, or a cold and dry one, with reft, more frequent bathing than ufual, or from a diarrhoea fuddenly arifing, and laflly from a nervous concuffion from a difagreeable affedtion of the mind. However, the continuance of life does not depend on afcrupulous exactnefs in the quantity of this difcharge, which is fo eafily increafed or diininifhed by flight caufes ; which is fhut up by paints in many Indian na- tions, and is inconfiderable in many animals without any fenfible injury. When it is fupprefied, it does a prodigious deal of mifchief in fevers of a bad kind j it hurts chiefly by its putrefcent qualities, which are re- tained by fupprefled perfpiration. 440. 1 he fweat is evidently of a faline nature ; as appears both from the tafte, and from the minute cry- ftals which fhoot upon the cloaths of fuch as work in glafs-houfes ; as well as by diftillation, which fliows the fweat to be of an alkaline nature. Hence it is, that by this difcharge the mofl malignant matter of many dif- eafes is thrown off from the body. But, in reality, fweat is always a preternatural or morbid difcharge, from which a perfon ought always to be free ; unlefs by violent exercife, or other accidents, his conftitution is for a fliort time thrown into a difeafed flate. l\or is it unfrequent for fweats to do confiderable mifchief in acute difeafes ; by wafting the watery parts, and thick- ening the reft of the blood, at the fame time that it renders the falts more acrimonious. By a too violent motion of the blood, the fweat is rendered extremely fetid ; and is fometimes even red, or mixed with blood itfelf: being eleclrized, it fometimes is lucid. 441. The ufes of perfpiration are, to free the blood from its redundant water, and throw out thofe par- ticles which, by repeated circulations, have become alkaline or otherwife acrimonious ; and poflibly to ex- hale therewith an extremely volatile oil, prepared from the fame blood. The fame perfpiration likewife quali- Chap. XIII. TOUCH. 217 fies and foftens the cuticle, which is a neceflary medi- um extended before the tender fenfible papillae. 442. But the fame flcin that makes this exhalation into the air, is likewife full of fmall veffels, which in- hale or abforb thin vapours from the air, either perpe- tually, or at lead when it is not very cold ; more efpe- cially when the air is damp, the body unexercifed, the mind opprelfed with grief, or both under conditions contrary to thofe which increafe perfpiration before- mentioned (438.) Thefe veins are demonftrated by anatomical injections, which, if thin or watery, fweat through them in the fame manner as through the ar- teries, if it was watery and thin ; moreover, the ma- nifeft operation of medicines in the blood, which were exhaled into the air, or applied to the Ikin, prove the fame ; fuch as the vapours of mercury, turpentine, faf- fron. Bath-waters, mercurial plafters, tobacco, colo- quintida, opium, cantharides, arfenic, with the fatal ef- fects of contagious or other poifons entering through the Ikin ; as in the venereal infection : to which add, the living of animals almofl; without drink in hot iflands, which abound with moift vapours ; from which, how- ever, they fweat and pifs plentifully enough. Laftly, fome extraordinary morbid cafes have demonftrated thisf in which a much greater quantity of urine has been difcharged than the quantity of drink taken in ; in which you may believe that the moft open paffages ferved for inhalation ; that new ones were generated, is not credible. The proportion of this inhalation is diffi- cult to affign ; but that it is very great in plants, more efpecially in the night-time, appears evidently from cer- tain experiments. 443. Thefe cutaneous veffels, both exhaling and in- haling, are capable of contraftion and relaxation by the power of the nerves. The truth of this appears from the effects of paffions of the mind ; which, if joy- ful, increafe the circulation, and relax the exhaling veffels, fo as to yield eafier to the impulfeof the blood ; from whence, with a Ihortening of the nerves, there F f follows ■21 8 TASTE. Ghap.XIV, follows a rednefs, moifture, and turgefcence of the Ikin. Thole paflions, on the contrary, which are for- rowful, and retard the circulation, contrail the exha- ling veffels; as appears from the drynefs and corruga- tion of the fkin, like a goofe-Jhm^ after frights ; and from a diarrhoea caufed by fear. But the fame affections feem to open and increafe the power of the inhaling veffels, whence the variolous or peftilential contagions are eafily contracted by fear. CHAP. XIV. Of the Taste. 444. T^ROM the fenfe of touch, and Its organ, there is but a finall difference or tranfition to that of the tajle ; which appears by certain experiments to be feated in the tongue chiefly ; for even fugar applied to any other part of the mouth, excites fcarce the leaft fenfe of tafte in the mind ; neither will any other fapid body, unlefs it contains fomething vehemently penetra- ting ; in which cafe the palate, root of the tongue, u- vula, and likewife the oefophagus, are affected with the tafle. That fenfation which is fometimes excited in the flomach, oefophagus, and fauces, by the regurgitation of tire aliments, feems alfo to belong to the tongue, to- which the fapid vapours are fent back, uncommonly acrid and penetrating: and even that fenfe which is fometimes occafioned in the flomach, eefophagus, and fauces, from a rifing of the aliments, feems alfo to be owing to the tongue, to which the taflable vapours are conveyed. 445. Onlj^ the upper and lateral edges of the tongue are fitted to exercife the fenfe of tafle. But by the tongue we underfland a mufcular body, broad and ful- cated in man, and lodged in the mouth, whofe pofle- rior and lower parts are varioufly conneCled to the ad- jacent bones and cartilages, while it remains moveable Chap. XIV. TASTE. 219 in its anterior and upper part. In tbofe portions of the tongue, which make the organ of tafte, the fkin grows to the adjacent mufcular fibres, b^ng continued from the fldn of the face and mouth ; here it is always foft and pulp-like, from the perpetual warmth and moifture. From this fkin arife innumerable nervous papllce, of a more confiderable bulk here than in other parts. Of thefe there are feveral kinds : the firfi; of •them are difpofed in a rank on the back part of the tongue, on each fide of the foramen ctecum. Thefe, furrounding that opening like a circle, are for the moft part like an inverted cone, having a deep finus in their middle; but are otherwife hard, and but indifferently difpofed for taftlng, although you can eafily trace the nerves to them. There are fome other papilla of the fame kind found fcattered before thefe upon the back -of the tongue. 446. Thefe degenerate into a klud of papillae like muflirooms, lefs and tenderer than the former, of a very cylindric and fomewhat oval figure, placed at fome fmall diftance from -each other, upon the upper furface of the tongue, v/here they' grow fharper point- ed as they lie more forwards, and are moll numerous on the Tides of the tongue. The third fort of papillae are of a conical figure, which abound m.ofi; in number among the former, and are fpread largely over the 'tongue. Thefe have their apices fomewhat inclined and fiudluating before, towards the tip of the tongue; thefe are likewife moft numerous in the fides of the tongue, though there are fome alfo behind the blind foramen. They are highly fenfible, and make the true organ of tafte : other papillaa lie between, which are partly coni- cal, and partly fliaped like threads ; and fome of the co- nical ones are greater, and the others grow always lefs and lefs. 447. Thefe papillae have doubtlefs fmall nerves de- tached into them, befides numerous velfels, although they are difficult to trace ; for we obferve, that larger nerves go to the tongue, than almoft in any inftance F f 2 which 220 TASTE. Chap. XIV. which we have in other parts. For befides the nerve of the eighth pair, which, being one of the principal of the three branches, deeply enters the bafis of the tongue, covered by the cerato-gloflus, near the os hyoides, there is alfo a confiderable nerve that goes to the tongue and its mufcles, from the ninth pair ; w'hich ha- ving inofculated with the fird nerve of the neck, and with the large cervical ganglion, it fends a branch downward, and frequently joins the eighth pair; but conftantly communicates with the fecond and third of the neck, from whence its branches afeend to the muf- cles arifing from the fternum, and frequently commu- nicate with the phrenic nerve; after which, the red of its trunk goes to the tongue. This communicates, by many branches, with the fifth pair in the cerato-glof- fus, and is more efpecially fpent in the genio-glolTus. Ladly, the third branch of the fifth pair having fent up or received the cord of the tympanum, and given other branches to the internal pterygoides, with the maxil- lary and fublingual glands, paffes with its principal trunk behind the cerato-gloffus, W’here it joins the ninth pair, and enters the tongue deeply, in company with the artery ; together with which it is extended to the tip of the tongue, where it becomes cutaneous. To this nerve, therefore, if there be any prerogative or preference, the fenfe of tade is to be more efpecially af- feribed, which is confirmed from obfervations on fome difeafes. Ladly, the nipples or papillte of the tongue are of a hard texture, each papilla having its pulpy fa- bric made up by a number of fmall nerves, arteries, and veins, conjoined or wound up together by a firm cel- lular fubdance into a button, or protuberance, of which many are required to make up one large papilla. 448. The arterial and venous down which runs be- tw'^een the papillae are for the purpofes of exhalation ; and have nothing to do with the tade, farther than that they feparate from the blood a liquor fit for diffblving falts, and keeping moid the papillte proper for tade : this liquor they pour out on the back of the tongue. On 221 Chap. XIV. T A S T E. On the upper and back part of the tongue are feated many fimple, round, muciferous glands, having one or more open outlets, which are completed by an hemi- fpherical membrane, and the fleftiy part of the tongue. Some of thefe open into the obfcure, blind, and uncer- tain figured hollow, which is placed in the middle be- tween the largefl papillae (445.), and commonly con- tains fome of them. 449. Over the papilla? of the human tongue is fpread only a Tingle mucous and femipellucid covering, which ftridly adheres to them, and ferves them as a cuticle. But, in brute animals, a perforated mucous network receives the papillae, which are in a manner wrapped up in cafes or capfules of this mucous body covered with the cuticle. 450. Under thofe papillae are fpread the mufcles which make the flefliy body of the tongue; which are very numerous, and hardly extricable in the human tongue: in the lower part, it is in a great meafure made up of the genio-gloffus mufcle extended outwards from the meeting of the chin, and diftributed like rays inter the fubftance of the tongue. The upper and lateral parts are compofed of the ftylo-gloffus, whofe fibres run to the tip of the tongue ; which in its middle part, betwixt the former mufcles, is compofed of one proper to itfelf, called Rngualis; which arifing from before the pharynx and origin of the ftylo-gloffus, only lower, goes out forward, and, terminating betwixt the faid genio-glof- fus and ftylo-gloffus, makes up a very confiderable part of the tongue. The back part of the tongue is made up of the fibres of the cerato-gloffus, which afeend upward and backward; which ends between the ftylo-gloffus and lingualis, being included between them: and to this is joined the chondro-gloffus, a mufcle entirely different, which arifes from the fmall bones, and next adjacent bafis of the os hyoides ; from whence paffing outward, with its lateral portions, covered by the genio-gloffus, it joins the ftylo-gloffus, and difappears in the tongue. By the adion of thefe ' mufcles. S^2 TASTE. Chap. XIV. mufcles, the whole tongue is moveable in all direclions, and capable of figuring its own fubftance, fo as to form a hollow, by the elevation of the ftylo-gloffi, which it again flattens by the cerato-gloffi, but contrafts itfelf into a narrow and almofl: cylindrical figure, by the tranf- verfe fibres from one fide to the other, together with which there are many other orders of fibres, intermixed with a thick fat ; fo that they cannot be traced in the human tongue. 45 1 . The arteries of the tongue are numerous. One that is larger and deeper afcends in a ferpentine courfe from the outer carotid, and extends to the tip of the tongue ; and a lefler fuperficial artery, incumbent on the fubiingual gland, either arifes from, or inofculates with, the preceding. Behind, there are various fmall branches derived from the pofterior labials ; and from the branches proper to the lips, or thofc of the tonfils. The veins of the tongue are varioufly wove, and diffi- cult to deferibe; fome of which, lying deep, accompany the nerve of the ninth pair; and others, that are fuper- ficial, accompany the mental artery, and, inofculating wnth the former, fends out the ranular vein : but all of them meet together in a large vein, w'hich is one branch of the internal jugular coming from the brain. Thefe veins varioufly communicate with the adjacent net- works belonging to the tonfils, pharynx, thyroide gland, and fldn; and in the back of the tongue, before the e- piglottis, there is a communication betwixt the right and left fide of the venal plexus. I find lymphatic vef- fels rather in the neighbourhood of the tongue, than in. the tongue itfelf. 452. Tht papilla of the tongue, which arc larger andfofter thanthofe of the fldn, perpetually moift, per- form the office of touch more exquifitely than thofe of the fmall and dry cutaneous papillse ; and from hence the tongue is liable to a fharper degree of pain : more- over, naked falts are not otherwife perceived than under afenfe of moifture, or of pain. But the papilla of the tongue being raifed a little protuberant, to perform the office TASTE. Chap. XIV. office of tafte, from falts diffolved in! water, or faliva, and applied againft their tips or fummits, are affedted in a particular manner ; which being diflinguiffied by the mind, and referred to certain clalTes, are called fla~ ■vours or tajies, either four, fweet, rough, bitter, fa- line, urinous, fpirituous, aromatic, or pungent and a- crid, of various kinds, infipid, putrid, and others re- fulting partly from pure faits, and in part from an in- termixture of the fubtile animal or vegetable oils, va-^ rioufly compounded and changing each other. If it be inquired. Whether the diverfity of flavours arifes from the different figures which are natural to falts ? and whether this does not appear from the cubical figure in which fea-falt flioots, the prifmatical figure of nitre, or the particular configuration of vitriol, fugar, &c. ? we anfwer. That this does not feem probable, for even taftelefs cryllals have their particular configu- rations ; and the tafte arifing from very different falts^ and differently qualified objefts of this fenfe, are too much alike each other, and at the fame time too incon- inconftant or changeablej to allow fuch a theory ; as for example, in nitre, i’he mechanical reafon, therefore, of the diverfity of flavours, feems to refide in the intrin- fic fabric or appofition of their elements, which do not fall under the fcrutiny of our fenfes. 455. But the nature or difpofition of the covering with which the papillae are clothed, together with that of the juices, and of the aliments lodged in the fto- mach, have a confiderable fliare in determining the fenfe of tafte ; infomuch, that the fame flavour does not equally pleafe or affeft the organ in all ages alike, nor in perfons of all temperatures j nor even in one and the fame perfon at different times, who fliall be differently accuftomed in health or varioufiy difeafed. In general, whatever contains lefs fait than the faliva itfelf, feems in- fipid. 454. The fpirituous parts, more efpecially of vege- tables, either penetrate into the papillae themfelves, or elfe are abforbed by the adjacent pile or villi of the tongue j 224 TASTE. Chap. XIV, tongue ; as may appear from the fpeedy recruifal of the ftrength by vinous or aromatic liquors of this kind, even before they are received into the ftomach. 455. Nature defigned the difference of tafles to be felt by the tongue, that we might know and diftinguidt fuch foods as are moll falutary : for in general, there is not any one kind of aliment healthy, that is of a difa- greeable tafte ; nor are there any ill tailed that are fit for our nourifhment. For it muft be obferved, that we here take no notice of excels, by which the moll healthy food may be prejudicial. In this manner na- ture has invited us to take necelfary food, as well by the pain called hunger, as by the pleafure arifing from the fenfe of tafle. But brute animals, who have not like ourfelves the advantage of learning from each other by inflruftion, have the faculty of diftinguifhing fla- vours more accurately, by which they are admonifhed to abflain cautioufly from poifonous or unhealthy food ; and therefore it is that herbivorous cattle, to which a great diverfity of noxious plants is offered amongft their food, are furnifhed with fuch large and long pa- pillae of fo elegant a flrudlure in the tongue, of w'hich we have lefs need. CHAP. XV. Gf Smelling. 4^6. O the fame ufe, likewife, of diflinguifhing prejudicial from falutary food, the fenfe of fmelling conduces; by which w'c even difeern and are admoniflied to avoid, before it comes to our tafle, what might be otherwife dangerous: and thus we are efpecially enabled to avoid any thing of a putrid ten- dency in our victuals, which is to us of a mofl peflilent nature, and likewife find out what are grateful and wholefome aliments ; although continual praftice, even in this faculty, has alfo rendered it more ufeful and ac- quitted Chap. XV. S M E L 1 I N G. 243 curate among brute animals than in ourfelves. For men who have been brought up wild by themfelves, without debauching the fcent by a variety of fmells, have been obferved molt certainly to retain that faculty. Finally, the powers and virtues of medicinal plants are hardly to be better known than by the fnnple tefliinony of tailing and fmclling. From hence it is, that in all animals thefe organs are placed together ; and from hence the fmelling is ftronger, and the organs larger, in thofe animals which are to feek their prey at a con- fiderable dillance, or to rcjedl malignant plants from among thofe that are fit for food. 457. The fenfe of fmelling is performed by means of a foft pulpy membrane, full of pores and fmall veffels, which lines the whole internal cavity of the noftrils, be- ing thicker upon the feptum and principal convolu- tions, but thinner in the finufes. Within this mem- brane are diftributed abundance of foft nerves through- out the middle of its fabric, from the firft pair (357.), which defcend through the holes of the os cribrofum into the feptum narium ; but in fuch a manner, that it is very difficult to trace them to their extremities and into the feptum. Other lateral nerves come from the fecond branch of the fifth pair and its branches, from that which lies tranfverfe in the pterygoide canal, and from another which defcends through the canals of the palate ; and foine from the infra-orbital-branch in the maxillary finus, from the dental branch, and from the anterior nerve of the palate. Moreover, the fore-part of the feptum has a fmall twig from the ophthalmic of the firfl branch belonging to the fifth pair. ^58. The arteries which go to the nofe are manyt from the internal maxillary branches; from the three nafal ones, to wit, the upper and both ethmoidal branches; alfo from the frontal, nafal, and fide branches ; from the lefler ophthalmic branch of the internal carotid ; from branches of the palatine artery ; from the infra-orbital within the finufes ; and from the fuperlor dental one. It is proper to thefe arteries G g very 244 smelling. Chap. XV. very cafily and very plentifully to fweat out blood, without any confiderable injury to the velTels them- felves. The veins run together in company with arte- ries, and form a large plexus, by uniting upon the ex- ternal pterygoide inufcle, and communicate with the fmufes of the dura mater ; from w'hence they open to- gether into the outer branch of the internal jugular. ' The arteries fupply the nourUhment, warmth, and mu- cus, neceffary ta thefe parts. 459. The neceffary reduction of the human head to that of a round figure, has in us given to the organ of fmelling but a fmall extent of furface ; but to enlarge this the more, nature has made the internal parts of the nofe varioufly hollow' and complicated, in a furprifing manner. Firft then, by the jiares we underhand the multiform cavity which begins before from the noftrils, and, extending tranfverfely backw'ard over the roof of the palate under the os cribrofum, terminates at the cavity of the fauces. This cavity is divided into two by a feptum or partition of bone, which defcends above from the plate of the cribrofum, but below is formed by the vomer, and in its fore-part is completed by a triangular cartilage, w'hofe furface is largely extend- ed and very fenfible. 460. Moreover, the lateral furfaces of the nares are increafed by ‘the fpiral volution of the cjfa turhinata ; the uppermoft of which are fmall turns or folds of a fpiral figure from the upper part of the os cribrofum. The middle fold belongs to the fame, fomewhat ob- long like a fhell, internally convex, externally con- cave, rifing into an edge on each fide ; all over rough with little finuofities or excavations, and inwardly fill- ed with fpungy cells or receffes ; the whole being fuf- pended in a tranfverfe pofition, and fupported by par- ticular eminences in the bones of the palate and upper jaw. The lowermoft turbina, fomewhat like the mid- dle ones, do like them refemble the figure of a limpet fhell, but longer ; for the moft part divided from the former, but foinetimes conjoined by a bony plate, which Chap. XV. SMELLING. 245 which is mon: frequently of a membranous nature. This bony appendix, being extended upwards in a fquare form, ferves to complete the maxillary fmus. 461. From hence the cavity of the nares is enlarged or dilated by various fmufes, which are a fort of re- ceffes or appendages to the whole. And firll, the: frontal or uppermoil fmufes, which are not always pre- fent, are of an irregular figure, intercepted betwixt the anterior and pofterior plate of the frontal bone, where it forms the fuperciliary protuberances ; and thefe, being not found in a fetus, feem to arife from the aftion of the corrugator and other mufcles, which draw the anterior plate of this bone outward, fo as to increafe the diploe into large cells, in the fame manner as we obferve in the maftoide procefs. Thefe open in the upper part of the nares into the interior cell of the cs papyraceum. There are inffances of their being totally wanting, and growing after the birth. 462. In the fecond place come the ethmoidal fmufes; which are four or more on each fide, in the outer part of the os cribrofum, like the cells of an honey-comb^ completed above by the cellular middle part of the os frontis, and before by the os unguis ; behind by the bone of the palate and fphenoid bone ; from whence they open by many ftnall tubes, placed one above ano- ther in a tranfverfe pofition, into the upper part of the nares. With thefe are continuous the cells in the pave- ment or bottom of the orbit, and thofe engraved in the os planum and maxillare are continued from them outward. In a third place, this finus is contiguous on each fide with the cavity or firms of the multiform bone, extending largely on each fide towards the os cribrofum and palatinum, which is itfelf formed in a dry prepara- tion, by a cartilage of large extent in the fetus, and by a folid bone, which gradually widens under the fella turcica, with an ample cell, either fingle or di- vided ; and opening forward, by its aperture or fora- men, into the fuperior part of the meatus narium. 463. The laft, lowermoft, and biggeft hnus, which G g 2 in 246 SMELLING. Chap. XV. in a fetus is inconfiderable, but in an adult very large, is that formed in the bone of the upper jaw by feveral thin bony plates. The opening of this into the nofe is betwixt the os unguis, bone of the palate, and the proper lamella or plate which accedes to it from the bottom of the os turbinatum. Which opening is fo much leifened by the furrounding mem.branes, as to form only a moderate round aperture in the fpace be- twixt the middle and bottom of the os fpongiofum. But it hkew'ife fends forth an hollow appendix, tending forwards, under the orbits which the os planum, un- guis, and papyraceum complete, communicating like- wife with the ethmoidal cells, and open behind the o- ftium lachrymale. 464. The nerves of the nofe, being almoft naked, required 'a defence from the air, which is continually drawn through the noflrils and blown out again by the ufe of refpiration. Nature has therefore fupplied this part, which is the organ of fmelling, w'ith a thick in- fipid mucus, very Iluid in its firO; feparation, and not at all faline, but by the air condenling into a thick dry cruft, more confiftent here than in other parts of the body. By this mucus tlie nerves are defended from drying and from pain. It is poured out from many final 1 arteries of the noftrils; and depofited partly into nu- merous cylindrical duels, and partly into round vifible cryptm or cells fcattered all over the noftrils. The fame flows out all over the furface of the olfactory mem- brane, which is therewith anointed on all fides. In the feptum runs down forward a long finus to a confi- derable length, which is common to many muciferous pores; this mucus is accumulated in the night-time; but, in the day, expelled by blowing the nofe, or fomc- times more powerfully by fneezing ; and may oflend by its excefs or tenuity, or irritate by too great thicknefs the very fenfible nerves, from whence a fneezing is excited for its removal. But the fmufes of this part, which abound with mucus, are this way varioufly eva- cuated, agreeable to the different pcftures of the body; Chap. XV. S M E L L I N G. 247 by which always fome of them are at liberty to free themfelves, whether. the head be ere£l:, or inclined for- ward, or laterally ; yet fo, that generally the maxillary and fphenoldal linufes are more difficultly emptied than the reft. Moreover, the tears defcend, by a channel proper to themfelves, into the cavity of the nofe, by which they moiften and dilute the mucus. 465. To the extreme parts of the nares or organs of fmelling, is prefixed the nofe ; lined inwardly with a membrane of the fame nature ; and compofed of two bones, and ufually fix cartilages, two of vs hich are continu- ed together into the middle feptum (459.) Thefe carti- lages render the nofe moveable by its proper mufcles, fo as to be raifed and dilated by a mufcle common to the upper lip, and to be contracted together into a nar- rower compafs by the proper depreflbr and comprelfor mufcle pulling down the feptum. Thus it forms an air-engine, which, for the reception of fmells, can take air in a larger quantity by dilating ; then contracting again by elafticity, when the air is afterwards abundant- ly thrown out. 466. The air, therefore, filled with the fubtle and invifible effluvia of bodies, confifting of their volatile, oily, and faline particles, is, by the powers of refpira- tion (265.), urged through the nofe, fo as to apply the faid particles to the almoft naked and conllantly foft ol- factory nerves, in which a kind of feeling is excited, w'hich we call fyneUlng : and by this fenfe we diftinguifti the feveral kinds of oils, falts, and other matters, diffi- cultly reducible to daffes, which hereby we perceive in^ diftinctly ; whence they are diflicultly recalled to me- mory, though the odours already eftabliffied are fuffi- cient enough for our purpofes. This fenfe ferves to admonifh us of any pernicious putrefaction ; of any violent acrimony ; or of a mild, foapy, and ufeful dif- pofition in bodies. And as fait, joined with an oil, is the object of tafte ; fo a volatile oil, aided with falts, ferves to excite fmells ; whence the affinity of the two fenfes, which conjunCtly affift and move each other, may 24« SMELLING. Chap. XV. be eafily underftood. But volatile particles chiefly are dillinguiflied by frnell, and fixed ones by the tafle ; perhaps becaufe the thick mucous cuticle, fpread over the tongue, intercepts the action of the more fubtle fa- line effluvia from acting upon the tafle, which yet eafily affedt the fofter and lefs covered nerves of the internal nofe. We are ignorant of the reafon why fome fmells pleafe, and others difpleafe ; and perhaps cuftom may have fbme effedt in this cafe. 467. Smells have a very ftrong adtion, but of fliort continuance ; becaufe they are applied immediately, by the moft minute particles, to nerves which are very near to the brain itfelf, and almoft naked ; from thence too proceeds the force of poifonous vapours, and the re- frefliment from agreeable odours, by which fome per- rons are effedtually recalled to themfclves out of a dead fwoon, or even after drowning. From hence comes that violent fneezing, which often arifes from acrid par- ticles ; and a loofenefs or purging of the bowels, from the fmell of fome medicines, with the power of particu- lar antipathies. From hence is derived the pernicious effedfs of exceflive fneezing, more efpecially blindnefs, from the near confent or fociety of the nerves. But amongft the various parts of the nofe, the feptum, and more efpecially the os turbinatum, have a confiderable lhare in the organ of fmelling : fince thefe are parts multiplied in quick-feented animals, fo as to form beau- tiful fpires in hounds and other quadrupeds ; and in filh, wdio fmell by water, they are formed like the teeth of a comb, in an elegant manner. CHAP. XVI. 0 /" H E A R I N G. 468. A S the fenfe of fmelling diftinguifhes the final} Jl\. bodies which float in the air, fo that of hear- ing perceives the elaftic tremors or impulfions of the air itfelf. HEARING. Chap. XVI. 249 itfelf. Therefore, we obferve the fenfitive organ of the ear to be compofed in a different manner from that of any of the other fenfes ; as it is made up, for the mofl part, either of hard bones, or elaftic cartilages and mem- branes, which are the mofl exquifitely enabled to re- ceive and communicate the neceffary tremors. 469. The external part of this organ, called the au- ricle or outer ear, is a cartilaginous funnel, conneded, but with a fort of mobility, before and behind, to the bones of the temple, by means of a flrong cellular plate, and likewife by its own proper ligaments and inufcles ; but the mobility of this partis diminifhedby cuf- toni. This cartilage is of a very compound figure j in general of a kind of oval figure, yet marked with fpi- rals Handing up, and hollows interpofed, to which o- ther hollows and ridges correfpond in the oppofite fur- face. The outer eminence, called helix, begins above by a loofe tape, is carried round at liberty about the edge of the upper part of the cartilage, upon the pofle- rior fide of which it terminates in the fame loofe man- ner. Within the body of the cartilage, furrounded by the former, arifes a bifurcated eminence, meeting toge- ther in one, called the anthelix, which terminates in a fmall and fhort tongue called the antitragus. The re- maining part of the ear, called the concha or fhell, is, before, hollow ; behind, convex ; growing gradually deeper, with a crooked line or ridge running through its middle, under the denomination of the concha, which is immediately joined with the meatus auditori- us ; before which Hands a round moveable appendix of the cartilage, as a defence, called the tragus. 470. This whole cartilaginous body of the outer eaf is only furrounded by a thin fkin, and an empty cellular fubHance ; it is repleniflied with many febaceous glan- dules, which fupply an ointment. This part is gover- ned or diredled by certain mufcles, which generally lofe their ufe and aftion, from the cuHom of binding the head in children, which we are otherwife to fuppofe they were defigned by nature to perform. The uppermoH 25a H E A R I N G. Chap. XVI. of thefe mufcles arifes thin from the frontal and from the aponeurofis of the cranium j whence it is broadly fpread over the aponeurofis of the temporal mufcle, and is inferred into the anthelix, or neighbouring helix, at the fide of the anonymous cavity. The polterior mufcles, which are two or three, more or lefs, arc more robull than the former in a tranfverfe pofiiion ; and, arifing from the fame aponeurofis, are inferred into the convex part of the conch near the maftoidal bone ; the cavity of which conch they, doubtlefs, are defigned to open or enlarge. The anterior mufcle is one of the leaft, which, being fpread upon the aponeurofis of the temporal, is inferred almoft tranfverfely into the origin of the helix and neighbouring concha. Eut the lefier mufcular portions, which, though fhort, and not very confpicuous, look of a red colour, are probably of ufe to make fome change in the figure of this part. The tranfverfe mufcle of the outer ear, which, for a long way, conjoins the helix with the anthelix, ferves to open the auricle. The antitragic mufcle, defeending from the root of the anthelix to the antitragiis, ferves to widen the entrance of the conch. The tragicus, which lies upon the tragus, opens the entrance to the auditory pafl'age ; and the fmall mufcle of the larger notch or incifure, that lies betwixt the two cartilages of the auditory paffage, forming the tragus and antitra- gus, ferves to bring them nearer together, and to ren- der the meatus itfelf more tenfe and elaftic. The re- maining mufcles, the longer or larger, and the lefier of the helix, have hardly any great ufe ; unlefs it be to tighten or brace up the cartilages whenever we attend or liflen to the hearing of weak founds ; and, by draw- ing together the cartilages, they likewife render the auditory paffage more firm. 471. To the concha is connecled the meatus audito- rius, fomewhat of a round comprefifed figure, lefiening as it bends inward ; for a confiderable part bony, and bent forward in its middle. But, in its anterior and outer part, it is, in fome meafure, made up by three imperfed Ch.^. XVI. HEARING. 251: imperfedl rings, arifing from the concha and tragus, and united together, and to the bone itfelt, by interme- diate flefh, membrane, and cartilage. Upward and backward, the meatus is completed by a mere mem- brane. This is the (late of it in adult perfons ; for, in the fetus and new-born infants, the meatus is wholly cartilage, and becomes afterwards, in part, a bone by degrees. 472. Through the auditory palfage are continued the cuticle and true fkin, gradually extenuated and ex- adUy ftretched over the furface of the bone, by which it is rendered extremely fenfible of any itching pleafure or pain ; and, being repleniflied with irritable hairs, is by them admonifhed of any fordes or wax abounding, and guarding from the entrance of fmall infedis. But, in the cellular fubftance under the Ikin, which is here more firm, and makes up the greater part of the mem- brane (47 1 in a fort of reticular manner, are feated numberlefs round follicles or cells of a yellow colour, which pour out their contents by fliort dudts into the cavity of the auditory paffage ; at firft of an oily con- fiftence, but afterwards it becomes more thick, bitter, and inflammable like wax. This liniment defends the fenfible fkin and membrane of the tympanum from in- juries of the air, and keeps out or catches any fmall in- fers j hut, when accumulated in too great abundance m-thofe who are flothful or uncleanly, it may be the caufe of deafnefs, or a difficulty of hearing. 473. Into this funnel of the ear the fonorous waves of the air flow, which, from principles of mechanics, it muff of courfe collect together. The elaftic air only receives fonorous tremors or impulfions ; and transfers them, either alone or principally, much after the fame manner as we fee water, without air, transfer any im- pulfe that is given to it. From hence, the found is in- creafed in air that is condenfed, and is loft in a veflTel emptied of its air. But the medium receives thefe tre- mors, either from fome body ftriking againft it, or from the air itfelf colliding againft another body, or laftly H h from 252 HEARING. Chap. XVf. from the collifion of two bodies againft each other in the air. But the body which produces found, ought to tremble or vibrate in all, even the leaft of its particles, fo as to form alternate arches riling up from the former ftraight furface, and returning beyond the fame ; the curve line of the fame exceeding that of the founding body. From fuch a tremor, the contiguous air is beat into waves, whereby the parts of the air that lie outer- moll are comprelTed and fly back again fo foon as their elallicity gets over the impulfe-, whence the air flies again towards the fonorous body, where it is now more loofe and rarefied, to be there again comprelTed by im- pulfion ; and in the fame manner the anterior and outer portion of air, furrounding that which is impelled, is, by the action of the latter, comprelTed and removed far- ther from the trembling body, yet fo as to return again in its proper time by the force of elallicity, driving its contents to the tremulous body for the exciting of a new wave. Thefe ofcillations or impulfions of the air are required to fucceed each other with a certain velo- city; and, in order to render them audible, they mull not be fewer than 30 in a fecond of time. 4.74. Acute founds are, in general, yielded from bo- dies that are hard, brittle, and violently Ihook or llruck; but grave founds are from the contrary. Thofe founds in general are called acute, which are produced from more numerous tremorjs in an equal time ; and thofe ob~ tufe, which are produced from few tremors. As to any medium betwixt acute and grave founds, there is none but what is arbitrary. Cords, or other bodies, that yield the fame number of vibrations in a given time, are laid to be unifon; as thofe which make double the num- ber of ofcillations in that time, are faid to yield a tone that is an o£lave or eight notes higher; and other pro- portions betwixt the numbers of the vibrations have different names affigned to them. The Ihorter cords produce lliarper tones, and the reverfe, in a proportion diredlly as their lengths ; as thofe which are more ilretched afford lharper founds in a fubduplicate pro- portion Chap. XVI. HEARING. 253 portion to their tenuity, or to the weights or powers by which they are ftretched. Experiments to this pur- pofe are very eafily made with a monochord, or a feries of chords ftretched with weights. 475. The found, thus produced, whether acute or grave, ftrong or weak, is carried through the air with a celerity equal to about 1038 Paris feet in a fecond, and that with an uniform velocity, without abating in the larger diftances. But a contrary wind, caufmg the vibrations to extend more flowly, retards the progref- fion of found about A of its velocity. So likewife den- fity and drynefs of the air increafe the found, as a rare- faction and moifture of the air leflen it. Hence, in fum- iner time, founds move fwifter ; and in Guinea, it has been obferved to pafs at the rate of 1 098 Pariftan feet in one fecond of time. 476. The found, thus every way extended, meets with certain particles in all adjacent bodies, even in wa- ter and mercury, to which it communicates funilar tre- mors or vibrations, not only fuch as are in unifon with the original tone, and which yield a found in a more particular manner fenfible, but alfo it excites tremors lefs fenfibly, even in the other parts of bodies, which vi- brate in the various proportions of the fcale. From hence it is, that every found, which we hear, is a mix- ture of the original tone, produced by the . trembling body, in conjunction with fecondary tones generated from the elaftic tremors of the furrounding bodies. The ftrength of found is increafed, if one audible or primary tone follows the other fo clofely, that their fuc- ceflion cannot be diftinguiflred by the ear ; but if they follow each ocher fo fiowly as to be diftinguifhable by the ear, they produce an echo ; but to produce this, re- quires an interval of fix thirds of a fecond of time, or the diftance of 55 feet betwixt the refleCling or echoing body and the ear. 477. Sounds, being elaftic, are reflected from hard bodies in angles equal to thofe of their incidence. But Che fame found, uftiered into the open air, and dilating • H h 2 thro’ 254 HEARING. Chap. XVI. through an immenfe fphere, grows proportionably weaker: but if it be ufhered through a tube, in a cy- lindrical fhape, the ftrength of it is more confined toge- 'ther ; or elfe, by being colleflied into the focus of a pa- rabola or ellipfis, it becomes increafed, as we obferve in fpeaking-trumpets, from which the voice goes out parallel to the focus of the parabola, without fcattering the fonorous rays. 478. Therefore the fonorous waves of the elafllcair, being driven into the cartilaginous funnel of our ear, which is naturally inclined forward and outward in an high fituation, are repelled and collected together, by alternate reflections from its elaflic fidcs, into the cavi- ty of the concha, from whence it proceeds through the auditory pafTage, with a force fo much ftronger as the furface of the outer ear is larger than the light or fec- tion of the auditory pafTage. Through this pafTage, however cylindrical, the fame force is continued en- tire forward, and ineneafed by new refonances, excited from the percuflion of the elaflic cartilages and hard bones, fo as to mix imperceptibly w’ith the primitive found. 479. Moreover, the bottom or end of the faid audi- tory pafTage is terminated internally by a thin mem- brane, called the membrana tympani ; which, in adults, is of a roundifh figure, and placed with an obliquity ; but fo that from its upper appendix it projeds in- ward like a fhield, whilfl the part which lies above its middle projeds into the cavity of the meatus like a lliield. This membrane of the tympanum is compoTed of feveral plates, the firfl or outermofl of which is white and mucous ; the other is a true fkin, continued from the membrane of the meatus, and of avafcular texture; the third is a dry, rattling, fplendid, and pellucid membrane or plate, without blood-veflels ; and thein- siermofl is the vafcular periofleum of the auditory paf- fage and tympanum, with a tender cellular texture ly- ing between. This membrane is not naturally perfo- rated with any opening, fo far as I have been able to Chap, XVI. HEARING. 255 difcover, and the tranfmifTion of fmoke is fabulous. It is conftantly fo flretched in the fulcus or groove of the bony ring, in which it is contained, proper to the fetus, and after the birth coalefcing with the reft of the os pe- trofum, that there is no part of the human body to be found more tenfe or more tremulous than this. Upon the furface of this membrane, and more efpeclally upon its conical cavity pointing inward, the fonorous waves ftrike, after they have received their laft refteftions from the auditory paffage, by which the elaftic fabric of this membrane is forced into ofcillation. 480. This membrane is ftretched over a cavity of the os petrofum, called the tympanum; which is, for the moft part, of a roundifli figure, but not regularly fo ; being divided in its middle into two by a promontory, and in the adult is increafed backward by the cells of the maftoide bone, which are abfent in the fetus. But alfo, in its upper and anterior and pofterior part, the tympanum has hollow cells, and, is lined with a vafcular membrane, receiving fmall branches from the internal carotid, and from a branch of the artery of the dura mater, which laft pafl'es through a fiffure in the aque- dudl, and it has others from the external arteries of the tympanum and from the ftylo-maftoidea. It is common- ly full of a mucus, poured into it from the Euftachian tube, and i$ divided by various membranes into a kind of cells, namely, by produdions of the periofteum to the little bones. 481. Within this cavity, three of the larger hones of hearings together with a fourth which is lefs, are ful- pended moveably. And firft, the malleus or hammer lies with its upper round head refting upon the conca- vity of the tympanum, from whence the handle of it is extended down, along the membrane of the tympa- num, betwixt the plates of it: having reached as low as the middle of the membrane, it terminates by a very clofe cohefion, with a broad extremity a little incurva- ted outwards. The fame bone is, moreover, connec- ted and fuftained by a peculiar ligament of its own, joining H E A R I N G. Chap. XVT. joining it to the longer leg of the incus ; and another membrane ferves as a fecurity near the longer procefs of the malleus. This bone drives outwards the mem- brane of the tympanum, which is fpread over the fhorter and conical procefs of its handle. From the fame place of this bone a broad, long, and flat procefs, goes out forward into a fulcus of the tube. It is articu- lated with the incus by two heads, having protuberant lines with a fulcus in the middle, and all of them ob- lique. In the malleus are commonly defcribed three mufcles: the firfl; and internal of which, called tenfcr tympanic being the largeft, is lodged in a particular groove within the tube, with w'hich it proceeds paral- lel ; and, rifing from the procefs of the multiform bone betv/een the paflTage of the cerebral carotid and the hole of the artery of the dura mater, bending round a pully, is inferred by its tendon reflected outward and downward into the beginning of the handle. The fecond inufcle arifcs from a fulcus in the fame tube, but externally fhorter than the former, and carried back almoft in the fame manner, but without being reflected : it adheres by a confiderable extent to the longer procefs ; and the fame is fufpected to be but little different from the red pulpy membrane. The third mufcle of the malleus, which arifes from the auditory paffage, paffes through a notch in the broken or interrupted ring of the tym- panum, and is inferted juft by the fhorter procefs into the malleus ; and this, which is by fome faid to relax the membrane of the tympanum, has never been feen with fufficient certainty neither by myfelf, nor by the mofl eminent anatomifls. For the reft, by means of the tenfor of the malleus, the membrane of the tym- panum is difpofed for the hearing of weak founds ; as the other mufcle ferves to moderate in too violent founds, by drawing the malleus from the incus ; by which therefore the propagation of the fonorous tre- mors is interrupted. If the membrane of the tym.pa- num be broke, or the bones of hearing diflocated, the perfon HEARING. Chap. XVI. 257 perfon becomes at firft hard of hearing, and afterwards perfeftly deaf ; this part being the feat of that flight hearing which is propagated through the bones of the fkull. 483. The malleus returns the tremors imprefled upon the membrane of the tympanum to the incus, which is a fliort thick little bone, articulated with the former behind by a broad furface, with two fulci and a middle eminence. The flrorter leg of this bone, whofe little body is bifurcated, being fufpended by a liga- ment, is held firm into a fulcus proper to the bone. Another longer one defcends parallel to the malleus ; and, by a fomewhat crooked extremity, is adapted to to the fourth orbicular bone which it receives, convex on one fide, flatter on the other, and refting upon the Rapes, to which its protuberances are imparted. 484. The fiapes, aptly enough fo called from its fi- gure, lies inclined, but more backward than forward, with a hollow head that receives the incus, from whence proceed two little crooked legs, the pofierior one of which is largefl; : but below, its oval bafts is occupied by an aperture of a correfponding figure, commonly called the fenejlra ovalls. Here the legs, which are fulcated inwardly, are conjoined by a tenfe membrane affixed to the hollow bafts. This bone of the (tapes is covered by its own mufcle, which being included in a bony papilla or cafe, fends out a fmall tendon, which is inferted under the incus into the head of the Rapes. Hence it feems to draw the Rapes, that it may lie higher up, under the back part of the feneRra ovalis, and pafs out of it before. Thus the nervous pulp of the veRi- bulum is preffed by the bafts of the Rapes, and by the air of the tympanum. The whole courfe or feat of the Rapes is feparated from the reR of the tympanum, by a membrane proper to itfelf. 485. A fmall roundifli oval-fliaped bone, here and there greatly excavated, is here fixed to the longer leg of the incus, and from thence goes to the fmall head of the Rapes. 486, There 258 HEARING. Chap. XVI. 486. There are various channels wliich pafs out from the cavity of the tympanum. Above the two larger bones behind the pofterior leg of the incus, is a fmall cell, a kind of appendix to the tympanum, of the figure of a gnomon. Behind that, the fmall cells begin in the os petrofum, above the mamillary procefs. Below thefe, that procefs is excavated in an adult by various fmall caverns. 487. From thence the proper canal, going out for- wards from the anterior extremity of the tympanum, emerges from the bones lying between the os multifor- me and the olfa teraporum ; and is joined into a corre- fponding elliptical and diverging cone, partly membra- nous, and in part made up of cartilages of a variable ftrufture : it opens by a very ample elliptical aperture, turning inward and forward behind the nares, into the cavity of the fauces : it is lined w'ith a porous mem- brane, full of cryptae and mucous cells, continued from and like unto the membrane of the nares. This is the tube which, by the aftion of the circumjacent mufcles, may be compreffed and clofed, and probably a little re- laxed and opened again, by the circumflex niufcle of the moveable 'palate. By this canal the infpired air enters into the tympanum to be changed or renew'ed, and the furrounding mucus of the little bones and o- ther parts are this way depofited : nor is it at all impro- bable, that the air enters by this tube, to fupport the tympanum, when it is prefTcd inward by the more vio- lent founds ; for founds themfelves, received into the mouth, are this way conveyed to the organ of hearing. In infpiration, the air prefies the membrane of the tym- panum outward : and from thence proceeds that clafh- ing or whifpering noife, by wdiich the heaving is obfeu- red, when the mouth is held wide open in yawning ; for then the air entering more abundantly through the cavity of the tube, to the tympanum, refills the tremors of the external air. 488. Two other paffages lead from the tympanum to the labyrinth^ or innermofl chamber of the ear. And, Chap. XVI. HEARING. iS9 And, again, the feneflra ovalis (484,) not covered by any membrane, leads into the vefUbulum'; which is a round cavity, formed in a very hard part of the os pe- trofum, that lies near the inner part of the tympanum. In that cavity are three receffes ; of which the upper one is elliptical, the lower one circular, and the third like a furrow. There is a nervous pulp in the veflibu- lum, diftinguilhed from the parietal bone by the vapour furrounding it. Into this open the five mouths of the three femicircular canals, the foramen ovalOj and the paffages of the nerves and arteries. 489. In the fetus, thefe are formed of a diftincl hard fhell, which, being furrounded with a fpungy bone, are lodged in a cavity of the os petrofum ; which, in adults* is extremely hard, extended into fegments fomething" larger than femicircles, which have an ample opening betwixt them. The larger pofterior and lower of thefe circles, is perpendicular ; alfo the middle and upper one Is placed towards the perpendicular : but the outermofi: and lead is horizontal. The inner mouth or aperture of the uppermofi; of thefe meets with the upper open- ing of the pofterior ring, and both join into one. 490. But the cochlea is a part ftill more wonderful* feated in an inclined pofture within the anterior por- tion of the os petrofum. Into one part of this cavity opens the veftibulum; and into the other the feneflra rotunda of the tympanum, which is concealed behind a protuberance in the bottom of the tympanum. The cochlea itfelf is made up of a nucleus of bone, of a co- nical figure, with its apex inclined inward ; divided by a middle fulcus, both through its bafis, and through its whole length ; and perforated with innumerable fmall foramina into the tubes, which are fcalce^ termi- nating in the middle of the fecond fpiral. About this nucleus are wrapt two turns and a half of a canal ; which, in the fetus, is made up of a diltindl fhell-like fubftance, peculiar to itfelf; and, in the adult, is united into one, with the adjacent bone : and this winding canal dimi- nilhes gradually in a conical figure, from the two fore- I i mentioned 26o rearing. Chap. XVL mentioned openings towards the tip of the nucleus. It is bilocular, or made up of two apartments, divided by a partition called lamella fpiralis. This, at its larger end, is bony, and extended out of the nucleus, at right angles, into a cavity j is ftriated, and every way wrapt up by the internal periofteum as in a capfule. Ano- ther external part hereto belonging, is a membrane^ which likewife divides tht canal : thus there are formed two diftincl femicanals, called fcala. The interior and pofterior of thefe canals begins from the feneflra rotun- da, where it is (hut by a membrane, and is called the fcala tympani; the other begins before, from the vefti- bulum, from which it has its name. In the tip of the cochlea is formed a' third cavity, fliaped like a funnel. Into this the fpiral lamina terminates by a membrana- ceous extremity, but fo that the funnel communicates with them by a fmall hole on each fide ; but, in many bodies, it alfo communicates with the cavity of the buc- ket that is filled v/ith the nerve. 49 1 . The blood-veffcls of the outer ear come from the temporal, or proper auricular branches; thofe to the membrane of the tympanum are either from the tem- poral, from the flylo-maftoideal, or from both ; thofe of the meatus auditorius come from the former ; thofe to the tympanum were deferibed (480.); and the velfels belonging to the vellibulum, cochlea, and femicircular canals, are from the vertebrals and ftylo-maftoideals. The indullry of late anatomifis has difeovered veffels of a particular kind, proper for carrying back liquids from the veflibulum into the tranfverfe finus, from the cochlea into the cavity, of the flcull. 492. It now remains that we deferibe the nerves de- ftined to the fenfe of hearing, of which the principal is that called the feventh (557-) This nerve enters into the internal auditory finus of the os petrofum, in the blind end of which it divides. The fmaller part of the nerve is fent upward, through the opening of a canal in the finus; whence palling tranfverfcly, it is after- wards bent behind the tympanum. In this part defeend- 21^1 Chap. XVI. HEARING. ing, it gives ofF_a branch through a peculiar channel to the tymparium, which afcends betwixt the malleus' and incus, and goes out of the tympanum, through a fiflure behind the articulation of the lower jaw, afterwards in- ferting itfelf into the nerve of the tongue (457.); the reafon of which fecret communication is oblcure, but ferves to explain the confent of the teeth fet on an edge by fliarp founds, a remo\'al of their pain by burn- ing the ear, &c. The reft of the nerve, elcaping by the fides of the ftyloide procefs, is diftributed through the external ear, the parotid gland, a large part of the face, and upper part of the neck, both cutaneous and muf- cular ; and in the face forms nuntberlefs inofculations, both betwixt its own branches, as well as with thofe of the firft, fecond, third, and fifth pair ; and it likewdfe communicates with the eighth pair, and the third cer- vical pair. But to the immediate organ of hearing it fends either no branches, or at leaft very fmall ones. The outer ear again receives other nerves in its fore part from the third branch of the fifth pair, and in its back part to the fecond and third of the cervicals. 493. But the foft portion of the auditory nerves arifes larger, but more oblcure, from the fourth ventricle of the brain itfelf (357-) and enters by very minute threads through exceeding fmall holes of the inner auditory fi- nus, which go in part to the veftibulum, and in part to the furrow of the cochlea. The branches in the vefti- bulum form a pulp-like tender membrane, which is e- very way extended thro’ the femicircular canals. The other part entering the furrow of the cochlea, has an obfcure termination. 494. With refpedl to the nerve which is diftributed through the veftibulum and femicircular canals, there is no doubt but it is ftruck by the tremors of the ex- ternal air, propagated to the ftapesj from whence the tremors immediately pafs through th^oval feneftra, to prefs upon the naked pulp of the nerve. That part of the nerve which enters the cochlea, is altogether ob- fcure in its termination. It is probable, that fmall I i 2 brancheSj 26a HEARING. Chap. XVI, branches from thence pafs through the little foramina (490.) to the periofteum of the cochlea, and to the membranous part of the fpiral partition. Do the tranf- verfe nervous filaments pafs out from the nucleus of the cochlea, all the way fucceffively fhortcr through the fpi- ral plates? Is it the organ of hearing? Thefe are que- {lions, which we are yet hardly able to refolve from a- natomy; though this feems repugnant to the courfe v/hich we obferve nature takes in brute animals, in birds, and in fifhes, who all hear very exquifitely with- out any cochlea. However this may be in the human body, it is there probable, that the fpiral plate, fpread full of nerves, is agitated with tremors from the ofcilla- tions of the membrane of the tympanum, by which the air in the cavity of the tympanum is agjtated, fo as to prefs the membrane of the round feneflra, which again agitates the air contained in the cochlea. 495. The preceding conjecture is indeed elegant; fince the fpiral plates make up a triangle, ending in a {liort point towards the tip, by which it may be concei- ved to contain an infinite number of nervous cords, continually fiiortening in their length ; and by that means adapted to aii harmonical unifon or confonance (474.) according to the variety of acute and grave founds, fo as to tremble together at the fame time with moll of them ; namely, the longeft cords in the bafis of the cochlea, with grave founds ; and the fhortefl cords nearer the tip or apex, with the fliarper founds. "Whe- ther are founds perceived in the middle femicircular canals, when thefe alone are found in all clalfcs of ani- mals? Are they detained in thefe canals, in the cochlea, and by the membrane fufpended through the veftibu- luin? This feems probably the cafe. 496. From what has been faid, it appears, that the elaflic wavps or tremors of the air arrive through the outer ear and auditory pa{fage,to the membrane of the tympanum; which being injured, and not repaired, the hearing is totally deftroyed. This feems to be ftretched, for hearing weak founds, bv the mufcles ot the malleus. From Chap. XVI. HEARING. From this membrane the found is conveyed through the fmall bones to the veflibulum ; for thefe bones be- ing deflroyed, the hearing is again aboljfhed. The bony (ides of the veflibulum, by their tremulation, agi- tate the fmall quantity of aqueous fluid furrounding the nervous pulp. It feems to be (truck by the nervous pulp fufpended in the veflibulum, and that tremor to be continued through the continuous pulp of the cochlea and femicircular canals. Of more than this we are not certain : but, by undoubted experiments, tremors, and even elaftic founds, communicate them- felves by the internal Euflachian tube, and through all the bones of the (kull, fo as to imprefs their force upon the auditory nerve. q97. The diftindion of founds, doubtlefs, proceeds from the celerity of the tremors excited in the hearing nerve, according as they fucceed each other more fwift- ly or (lowly, in a (liort time ; in order to which, it is not neceffary the mind (hould number them ; it is fuffl- cient that (he perceive their numbers to be different, and that this difference excites a variation in her thoughts and ideas thence arifing. Whether the harmony or agreeablenefs of founds arifes from the number of parts founding together in unifon ? and whether the mind, ignorant of herfelf, numbers the degrees of confo- nance, fo as to pleafe herfelf in a majority of them ? thefe are quedions denied by the mofl expert mufi- cians, who make it appear, that there is an agrqeable- nefs, and that very confiderable, in founds approach- ing the lead to a confonance, and which lies in a pro- portion very difficult to determine. Why do founds often become too (harp for the ear ? Our auditory nerves feem to be drained upon the fpiral plates, in fuch degrees as to be in danger of breaking, after the manner drinking-glafles may be broke by fliarp founds, and as the hearing is fometimes almod lod for a while by the violently flirill whidlings of the inhabitants of the Canary iflands. CHAP. 264 SIGHT. Chap. XVII. CHAP. XVII. Of the Sight. 498. AS the organ of hearing perceives the tremors Jl\. of the air, fo the fight perceives thofe of light ; and as the firft confifted chiefly of bony organs capable of making a refonance ; here, on the contrary, the greater part of the eye is compofed of pellucid hu- rnours capable of refrafting the more fubtle medium of light : but the complexity of this organ was neceflary for the defence of its tender parts, and from the diver- fity of the feveral humours, to be contained each in their proper integuments. 499. Outwardly, a defence is afforded to this organ by the eye-brow or fuperciHum, which is a protube- rance of the fkin, fuflained by mufcles, at the bottom of the forehead, full of thick hairs, lying over one an- other like the tiles of a houfe ; and capable of being pulled down by the adion of the frontal, corrugator, and orbicular mufcles, fo as to afford a fliade to the eye in too flrong a light. After this office is finifhed, the eye-brow is raifed again, by the infertion of the frontal mufcle, thin and flefliv, immediatelv under the conti- nuous fkin, faftened to the cellular membrane of the fkull, which is of a fliining fubflance, and not far diffe- rent from the nature of an aponeurofis, which, being of a long quadrangular figure, is drawn backward by the occipital mufcle. A depreflion of the eye-brow ferves alfo to exprefs concern of the mind ; as an ele- vation of it denotes the mind to be in a ferene quiet ftate. This guard alfo conduces to throw off the fwcat and retained duff, or the infedts which might fall into the eye. 500. I'he eye-lids, or palpebrse, are placed ffill nearer guards before the eye. Here the folds of the fkin, which are thinly extended, from that of the face, run out Chap. XVII. SIGHT.' 265 out in a confiderable length, and are reflected back with the cellular fubftance interpofed betwixt the outer and inner plate ; the latter of which becomes then a thin vafcular membrane, and therefore of a red colour, ex- tended before the globe of the eye, and fpread in its foremoft part upon the fclerotica, under the denomi- nation of co7ijundiva tunica. This production of the fkin is every where covered by another of the cuticle, even where it is clofely conjoined with the cornea. The upper eye-lid is larger and more moveable : the lower is fmaller ; and rather obfequious to the motion of the other parts, than moved by any particular forces of its own. The nerves., which give fenfibtiity to the eye-lids, are numerous, from the firft. branch of the fifth pair, and likewife from the fecond, and from the hard branch of the feventh pair ; they abound with arteries from the ophthalmics, and from the branches of the tempo- rals, internal maxillaries, infra-orbitals, and others of the face. 501. That the eye-lids might (hut together more exactly, they have each of them a cartilaginous arch, called tarfus., upon their margins, w'hich meet toge- ther. It is flender, of a lunar figure, extenuated outward, and ferves to hinder the eye-lid from falling into wrinkles while it is elevated or deprelfed. The elevation of the upper eye-lid is performed by a mufcle arifing from the involucrum of the optic nerve gradual- ly fpreading, and extended by its expanfion to the tar- fus. This elevator is confiderably affifled in its aClion by the frontalis, and by various connections with the orbicularis drawn up or dilated by the former. The upper eye-lid is deprelfed by the orbicularis mufcle ; which is broad and thinly fpread round the orbit, under the fkin of the eye-lids, to each angle of the eye, which ferve as fixed points to this mufcle ; and it adheres to the os frontis, where that bone joins the upper jaw, and then its fibres are inferted into the os frontis and nearefl parts of the upper jaw. The fame mufcle ferves to elevate the lower eye-lid, and covers the eye in fuch 266 SIGHT. CHAP.Xyif; a manner that no duH. or light can enter it in fleep. The lower eye-lid is depreffed by a double portion of fibres, inferted into the upper lip. 502. Finally, that the protuberant margins of the eye- lids might not injurioufly beat againft each other, the ci/ia or rails of hair are placed fpreading outwards, in a row, from the edges of the eye-lids, of dilFerent lengths, which by croffing each other make a blind or (hade. Thefe are of ufe in more diftinct vifion, by excluding the ex- traneous rays, when we require a diftincl reprefenta- tion of any objedl. 503. That the eye-lids rubbing againll each other might not grow together, they are fupplied with a row of febaceous glandules^ firfl; noticed by Meibomius ; namely, about thirty little gut-like cells or more in each eye-lid ; placed in general according to the length of the lid, without ever branching, but compofed of pe- culiar blind finufes, which end at laft in one larger fer- pentine duft, opening by a mouth in the margin of the eye-lid itfelf. Thefe difehargt a foft liniment, which mixes and walhes off with the tears. 504. But the perpetual attrition of the eye-lids a- feending and defeending againft the globe of the eye, is prevented by the diftilling humour called tears ; which preferve alfo the tendernefs of the membranes and of the cornea, and ferve to wafli out any infects or other lharp corpufcles. -Thefe form a faline pellucid liquor, that may be evaporated, and never ceafes to be poured over the anterior furface of the eye ; but ne- ver runs over the cheeks, unlcfs collefted together in a larger quantity from foine caufe. This liquor is ex- haled partly from the arteries of the conjunftiva, as we fee from an imitation of nature by injediing water : and it is in part believed to proceed from a gland feated in a recefs of the orbit of the os frontis,fomewhat hard, and of the conglomerate kind ; intermixed with fat, and paint- ed with many blood-veffels from the ophthalmics and internal maxillaries 5 and interfperfed with many fmall netves Chap. XVII. SIGHT. nerves arifing from a peculiar branch of the firft trunk of the fifth pair. 505. From this lachrymal glandule in horned cat- tle defcend three, four, or more vifible dufts, which open on the inner fide of the conjundiva, upon the eye-lid. In man theie dudls are lately found out, ac- cording to credible authors. The feparation of the tears is increafed by the more frequent contraftion of the orbicular mufcle, either from irritation, or fome forrowful paffion, by which means the tears are urged over the whole furface of the eye and conjundliva, which they walh, 506. After the tears have performed their office, fome part of them flying off into the air, the reft, that they might not offend by their quantity, are propelled by the orbicular mufcle, towards its origination next the nofe, to a part which is the loweft of the palpebral margins ; which not being furrounded by the tarfus, does therefore not meet exactly together. Here a ca~ runcle full of febaceous hairy follicles, of an oblong figure, interpofes and feparates the meeting of the eye-lids, at the fame time furnifhing a liniment to thofe parts which have none of the Meibomian duds. Be- fore this part is extended a fmall portion, like a little eye-lid; which, defcending perpendicularly, joins the • true eye-lids, and is larger in beafts than in men : but at the beginning of this fpace, betwixt the eye-lids, in which the tears are colleded, both in the upper and lower margin, a little papilla ftands out, having each of them one opening, furrounded by callous flefli, which are perpetually open, unlefs when convulfively clofed. This opening, which is called the punBum la- chrymale^ drinks up the tears from the finus in which they are colleded ; and this partly by tubular at- tradion, and partly by impulfe from the orbicular mufcle. If thefe points or openings are obftruded, the tears run over and excoriate the cheek, 507. From both points proceeds a fmall dud, both from the upper and the lower eye-lid, much- wider than K k the 268 SIGH T. Chap. XVIL the opening itfelf, but thin, and included in the Ikin ; one of which goes downward above the caruncle, and the other goes more tranfverfely inward and under it ; thefe both join together, and are inferted by two mouths near the uppermofl; part of the lachrymal Jack: thus it is called a cavity, formed in the os unguis and up- per jaw, lined with a membrane, which is at firft cellu- lar, but harder, and as it were of the nature of an apo- neurofis ; then by another red and pulpy one, continu- ed from the membrane of the nares, pervious to the exhaling dew, and fomewhat of an oval figure. From the fame facculus is continued a duft, which defeends a little backward into the nares, opening there by an oblique oblong aperture at the bottom of the meatus, covered by the lower os fpongeofuin. Through this paffage the fuperfluous tears defeend into the nofe, which they in part moiften (464.) A mufcle is by fome aferibed to this fack j but it is not yet fufficiently con- firmed. 508. The globe of the eye, comprefl'ed before, but longer than it is broad, is feated in the cavity of a bony orbit, which is almofl of a conical figure, made up by feven bones which are in the back part ; and on the inner-fide perforated or interrupted by larger fifl'ures, from whence the bones, widening forward, defend the cavity on all fides. But as this is larger than the eye itfelf, the excefs is on all fides occupied by a very foft fat, furrounding the globe of the eye, that it may both fill and have a free motion within the orbit. 509. The eye begins from a confiderable nerve, by the expanfion of whofe coats thole of the eye itfelf are compofed. The origin of this optical nerve we have already deferibed (^57.) Its progrefs is acrofs the crus of the brain, where it joins with its fellow nerve from the other fide, and coheres therewith for a confi- derable length by a large portion of medullary fub- flance ; fo that the right goes to the right eye, and the left to the left eye, yet not without fome conjunction of ef both medullary fubftances. The nerve, therefore, Chap. XVII. SIGHT. a 69 thus enters the orbit a little infle£led, of a figure fomc- what round, but comprefled ; and is inferted into the globe of the eye, not in the middle, but a little near- er to the nofe. 510. The nerve having reached the eye, depofitsthe inner plate of its dura mater, which it received in the opening of the fphenoidal bone : and this being ex- panded and rendered thicker, makes up the firft coat of the eye, called fclerotka. The other outer plate of the dura mater, receding from the former, makes up the periofteum of the orbit ; but the pia mater, which is in this nerve very diflinft and full of veffels, expands itfelf as before, fo as to form a thin dark-coloured li- ning to the fclerotica. The remaining inner medul- lary part of the nerve, continued from the brain, but divided into filaments by the cellular fubftance, is con- trafted into a depreffed white conical papilla ; after which it is again expanded upon the inner membrane of the eye, fo as to form the retina. 51 r. The fcelerotlca is in general white, tough, and furniflied with few veffels, refembling the nature of the cutis or fkin, of a figure completely enough globular, but compreffed or flattened before, and of a greater thicknefs backward. To the fore-part of this globe, cut off circularly, is prefixed obliquely a portion of a more eonvex but lefs fphere ; pellucid, and made up of many fcales or plates, repleniflied with a clear water and pel- lucid veffels, very difficult to demonffrate ; infenfible, and almofl circular, yet broader at the nofe than to- wards the temples : it is termed the ccrnea^thvo’ which the light paffesinto theinmoft part of the eye. This greedi- ly imbibes water, and fweats it out again. Before the an- terior and flatter part of the fclerotica,and alfo before the cornea, the conjun^iva is detached from each of the eye-lids, and clofely conjoined to the fclerotica by a proper cellular fubftance, that may be inflated (500.); which is repleniflied with veffels, partly red, and part- ly pellucid continuations of red ones. y 1 2- The origination of the cboroides is from the cir- K k 2 cum- SIGH T. ,870 Chap. XVII. eumference of a white circle, terminating the fubftance of the optic nerve, in that part where the retina and the central artery are expanded from it, and perforate it by many fmall foramina. From hence it fpreads within the fclerotica, concentrically adhering thereto by a cellular fubftance and many veflels, which enter from the choroides into the fclerotica. This membrane is outwardly of a brown colour, but inwardly of a more ruftet brown or almoft black, both which colour ancT furface are feparable by maceration : the innermoft may be diftinguifhed by the name of Riiyfch ; but grows white through age. When this has extended itfelf as far as the beginning of the pellucid cornea, it there joins itfelf more accurately to the fclerotica, by a cellular fubftance; from whence going off almoft circularly in a different courfe, it forms a kind of rim, called orhi- culus ciliaris: namely, the coat, which was before fphe- rically expanded, now fubtends circularly from the arch of the cornea, a little convex outwardly, and with a deficiency in its middle ; from whence a circular paral- lel portion is taken out, fo as to form a foramen or hole, called xhz pupil, wdiich is feated nearer toward the nofe, and is larger toward the temple. The anterior part of this round rim, is called the iris ; and the back-part, feparable from the former by maceration, is, from the black colour with which it is painted, called uvea. On the anterior fur- face of the iris appear numerous ftripes, extended like rays, of various colours in different people, the whole covered as it were with little locks of wool. Thefe go off beyond the pupil into a ferrated circle, from which tend other fimilar ftreaks, even to the edge of the iris. They are ferpentine in a broad pupil, but ftraight in a narrow one. On the pofterior face of the uvea is much black pigment; wdiich being w'aflied off, ftraight radiated ftreaks appear, produced into the pupil, but not woolly. Orbicular fibres, concentrical w'ith the pupil, I have not been able to obferve, neither with the naked eye, nor with amicrofcope, even in an ox ; but only in the u- vea, an internal circle diftinguiflied bv obfcurer ravs, but lefs Chap.XVH. sight. 271 lefs woolly. In the human fetus, the pupil and the iris being produced, makes a complete circle. That part of it which is drawn over the pupil is of a vafcular texture. 513. Though the iris has little fenfation, and is not endowed with any mechanical irritability ; yet in a living man, quadruped, or bird, it is conftritled on every greater degree of light, and is dilated on every fmaller one ; hence it is rendered broader for viewing diftant objefts, and narrov^er for viewing fuch as are near. The caufe of this' dilatation feems to be a reiniffion of the powers refilling the aqueous humour; an argu- ment of which, is the dilatation of the pupil, occafioned by debility, and which fucceeds fyncope and death. The contradion is more obfeure,' and perhaps only de- pends on the (Ironger _ afPiux of humours into the co- lourlefs vcffels of the iris, into which thefe veffels are extended ; and, along with thefe, the iris is rendered longer, and Ihuts the greater part of the pupil : \'o that this motion has fomething in common with a begin- ning inflammation. The pupil is more evidently mo- ved and contrafted ; as the eye gradually grows callous in old people, it is rendered aimoll; immoveable. In an animal twenty or thirty hours dead, I have feen the iris extend by heat, and fhut the pupil. 5 14. Behind the uvea, from the fame circle by which the choroides and fclerotica join together, and outward- ly adhere to the cornea, arife thick ftripes, extended from the choroides, elegantly wrinkled with parallel veflels, fpread under them, which are conjoined by fea- ther-like loofe and thin footftalks, into the retina, every way fpread with a good deal of black paint ; and de- parting, after the manner of a perforated ring, inward from the tunica choroidea, they fpread upon the vitre- ous humour ; and, laftly, are laid on the capfule of the cryftalline lens, but do not adhere to it, and are called by the name of the ciliary ligaments. The origin of the black pigment we are as yet unacquainted v/ith ; nor fan any glandules be found, which fome have alTigned 372 SIGHT. Chap. XVIf. for its reparation. Among its other ufes, one feems to be to keep firm the cryftalline lens. In infants, this fame mucus has the image of a radiated flower, behind the ciliary procefs. 515. But the retina, which is truly a continuation of the medulla from the optic nerve, is next expanded in- to a fphere concentric with the choroides, extremely tender, and almoft of a mucous confiftence, diflblvable by a blaft ; and this immediately embraces the vitreous body. But when the retina has extended itfelf as far as the ciliary proceflfes, it follows their courfe, making their ftripes and fmall arteries its foundation or fup- port in its courfe to the cryftalline lens, to the capfule of which it adheres ; and, if we may believe the olDfer- vations of fome anatomifts, as well as our own, fpreads upon its furface. 516. Thefc coats of the eye, which inveft and fup- port each other, after the manner ^of an onion or other bulbous root, give a fpherical figure to the eye, and include its humours : by which name are underftood commonly three fubftances ; the one a folid, the other a foft body, and the third truly a liquor. Firft, then, the common furface of the retina is, on all Tides, filled by the principal or vitreous humour, which is contained in a thin pellucid membrane of its own, of a cellular fabric, in the intervals of which is confined a moft clear liquor, a little denfer than water, which entirely evaporates by heat, like the aqueous humour ; from which nature it does not eafily degenerate, even in old people. Its velfels, which are moft manifeft in filh, lie in the back part ; are moft beautifully radiated from the central trunk of the retina, embracing the convexity of the vitreous humour ; and are inferted into a circle formed by other arteries coming from the choroides, not far from the lens, and which I have feen in a flieep. The vitreous membrane, which is tender confidering its body, is yet grown to the lens in two places, before and behind ; fo that the middle hollow ring is intercepted between both infections, round the cryftalline 4 Chap. XVII. SIGHT. 27^ cryftalline lens. Afterwards it Is divided by feme little ropes. The ftreaks of the ciliary body imprint their marks on the anterior face of it. 517. But, in the fore-part of the vitreous body, be- hind the uvea, there is an orbicular depreffion or finus confiderably deep, into the cavity of which the cryjlal- line lens is received, though that be lefs properly ranked in the clafs of humours. The figure of this lens is made up of two elliptical convex portions or fides, the foremofl of which is flatter, and the pofterior more gib- bous. The ftrufture of it is that of concentric plates or fcales, fucceeding each other, and compofed by the fibres themfelves, elegantly figured and contorted, and connected together by cellular fibres, fo as to form a tender cellular texture. Betwixt the cryftalline leaves is.alfo contained a pellucid liquor, which, in old age, turns of its own accord to a yellow colour. The in- nermoft fcales lie clofer together; and form at laft a fort of continued nucleus, harder than the reft of the lens : it does not fo adhere to the capfule, but, when that is broke, it very readily leaps out ; and fome fay that a little water is effufed around it. Its artery is from the retina, which perforates the middle of the vitreous hu- mour ; that is, the pofterior one ; for the veflfels in the fore-part are not yet known. This whole lens is con- tained in a ftrong, thick, elaftic capfule of a pellucid membrane, more firm in the fore-part, which is lined backward by the vitreous tunic. 5 iB. Laftly, the aqueous humour, which is extremely clear and fluid, and renewed again if it be let out, is feated in a fmall fpace of a curve-lined triangular figure betwixt the uvea and cryftalline lens, and in a larger chamber that is before betwixt the iris and the cornea. This humour feems to exhale from the fmall arteries of the iris, uvea, and ciliary proceffes ; being again ab- forbed into fmall veins of the fame parts, while fome portion of it is drunk up and exhaled through the cor- nea. This humour alfo waters the uvea and capfule of the lens. About the beginning of the prefent century. 2 74 SIGH T. Chap. XVII. the fpaces filled with this liquor w'ere called the camera of the eye ; the fore one between the cornea and iris ; the pofterior one, which is finall, between the circum- ference of the cryftalline lens and the uvea. 519, The eye, thus framed, is outwardly furrounded with mufcles, for its government and direftion. Name- ly, into the circle of the fclerotica, which is next to the cornea, are inferted four ftraight mufcles, arifing from the dura mater of the optic nerve at the bottom of the orbit ; where, departing from the nerve, they cohere with the periofteum, forming, as it were, one circle ; from whence, going forward, their bellies lie round the bulb of the eye, and terminate again by their aponeu- rofes, meeting together in another circle into the fcle- rotica. Of thefe, the elevator is the lead, and the ab- duSor the longeft. The office of thefe mufcles appears very plainly rn each of them apart ; fince, being bent round the convex bulb of the eye, as about a pulley, they muft , of courfe, elevate, deprefs, or turn the globe of the eye either to the nofe or to the temple. More- over, two of them acting together may turn the eye in a diagonal -betwixt the former directions; as upw'ards and outw^ards, upwards and inwards, &c. Laftly, when all the four ftraight mufcles are contracted toge- ther, there is no doubt but they draw the whole eye towards its origin within the orbit, by which means the cryftalline lens is moved nearer to the retina. 520. But the two oblique mufcles of the eye are of a more compound fabric. The upper of thefe, arifing together with the recti, is long and flender, afeending forw-ard to a notch in the os frontis, which is completed by a double ligament, cartilaginous on each fide, and hollow in the middle, almoft quadrangular, for fuftain- ing the tendon of the mufcle. Through this canal paf- fes the tendon of the obliquus fuperior ; which being again reflected backward and downward, included in a capfule of its own, is inferted into the globe of the eye behind the ftraight mufcles. This draws the globe for- ward and upward, in a manner out of the orbit, that the eye Chap. XVII. SIGHT. 275 eye may take in a larger field of vlfion ; it alfo turns the pupil inward and downward. The other leffer oblique mufcle, arifing from a finus of the lachrymal fo- ramen in the upper jaw, afcends immediately outwards from the os unguis round the globe of the eye, and is inferted by its tendon into the fclerotica behind the ex- ternal rectus ; whence it appears, on its part, to turn the eye downward and outward j and of courfe, contrary to the former, to direct the pupil upward and inward. 521. But there are other more minute mufcular mo- tions performed in the eye, which prefuppofe a know- ledge of the nerves belonging to this organ. And, firft, we have already fpoken of the optic nerve (509, 510.) The fourth pair goes only to the larger oblique mufcle, and the fixth pair belongs to the external rec- tus. The third and fifth pair produce the principal nerves in the eye ; and of thefe, the firft branch of the fifth produces the ophthalmic nerve, and fends off a fmall nerve from its entrance into the orbit, to the eye- lid and lachrymal glandule; it then conjoins with the fecond branch of the fifth pair, and with the temporal branch of the third and fifth pair. After having en- tered into the orbit, its trunk divides into two. The upper and larger fubdivides into two, which are fpent upon the forehead and eye-lids : but the lower, going inwards above the optic nerve, fends out long llender filaments to the outer part of that nerve, which, joining with another filament of the third pair, makes up the ophthalmic ganglion, and fends off one or two ciliary nerves. Finally, having given off a nerve, running to that of the nofe (457.), it is then fpent upon the diffe- rent parts of the internal angle of the eye. 522. But the principal dignity of the third pair lies in giving off a branch upwards to the ftraight mufcles of the eye, and to the eye-lids ; and then, going for- ward with its trunk under the optic nerve, it fends out three branches together to the lower and lefs oblique, and to the internal mufcle ; after this, or often before, (from its trunk, and fometimes from a branch of the L 1 lower '276 SIGHT. Chap. XVII. lower obliquus), afcends out another fhort and much thicker nerve, which fometimes joins the root of the fifth (521 .), or is fometimes folitary ; which, under the abduftor mufcle, conftantly forms the oval ophthalmic ganglion. From that ganglion, and fometimes from the trunk of the third or fifth, go out four or five ciliary nerves in a crooked courfe, playing round the optic nerve in their courfe to the globe of the eye, where they enter the fclerotica almoll in its middle, in com- pany with its longer fmall arteries or veins ; and run- ning thence ftraight forward through the choroides, they pafs vifibly to the iris, and feemingly to the ciliary proceffes. Other very fmall nerves, originating from the fame ganglion, remain in the tunica fclerotica. 523. Another more obfcure and lefs eafily demon- ftrable motion in the eye, is that of the ciliary proceffes (514.); which, lying incumbent upon the furrows of the vitreous membrane, feem, by their action, to prefs back that body, fo as to bring the lens forward, and fe- parate or remove it farther from the retina. But I have never feen, in all the animals 1 have diffeded, any thing like a mufcle in this ciliary body ; but a membrane which fupports the fmall veffels. As for any fphinder of the pupil, or a conflridor of the cornea, mentioned by fome writers of note, or even moving fibres, which others have imagined proper to the cryftaliine lens, they are in nowife fupported by anatomy, nor are they con- fident with the perpetual hardnefs of texture obfer- vable in the lens and cornea of molt animals. 524. Moreover, to the hiflory of the eye belongs a defcription of the veffels, which, in this part, have a beautiful fabric. But all of thofe which belong pro- perly to the fcveral parts of the eye itfelf come from the ophthalmic artery, a branch of the internal carotid (3 1 6.) This, creeping along under the optic nerve, fends out, as principal branches, the upper and lower ciliaries, one or more; the lachrymalis, from whence the pofterior running to the nofe, and internal part of that belonging to the arch of the tarfus ; afterwards the mufcularis Chap. XVII. SIGHT. 27? inufcularis inferior, the anterior recurrent to the nofej the uppermoft mufcularis, and the palpebralis ; from whence, with the former branch, fprings the arch of the tarfus. Laftly, it goes out forward to the face^ and adjacent parts of the nofe. But the ophthalmic branches, belonging to the inner fabric of the eye, are the pofterior and middle ciliaries j which, arifing from the trunks before-mentioned, and playing rotind the optic nerve, in four or more branches, in a Terpentine courfe, go partly in with the optic nerve at its firft en- trance, and are partly extended further to near the middle of the fclcrotica, where they fend in forty or more little arteries to the choroides, which make firfl: beautiful ramifications upon the external furface of that membrane, round, and like the branches of trees ; from whence they proceed inwardly in a more direct courfcj and at laft go to the circle of the uvea. 525. But feveral of the fmall arteries of the tunica choroides gradually decline towards the interior parts of the eye ; and, being covered with a kind of cellular woolly matter, go to the ciliary procefles, through each of which run out two fmall arteries, fcattering vafcular woolly-like locks, united by an handle at their apex. 526. Other fmall arteries alfo, likewife arifing from the ciliary ones, but few in number, moft commonly two, come to the fame bafis from which the membrane of the uvea originates. There, fpreading in various di- regions, they furround the root of the uvea with their branches, and are joined into a circle, into which the anterior ciliaries mix themfelves ; which are fmall ar- teries arifing from the mufcular branches of the oph- thalmic, near the origin of the pellucid cornea ; perfo- rate the fclerotica by twelve or more branches, and to- gether make up the circle of the pupil. From that circle, and likewife from the fore-mentioned anterior ciliary arteries, independent of the middle circle, are difiributed veflels, both on the anterior face, which makes the iris, and on the pofterior face of the uvea, together with the ciliary procefTes ; the vefiels are dif- L 1 2 ^ ttibuted, 278 SIGHT. Chap. XVII. tributed, both ftralght and ramified ; the iris is full of a liquor of a bluilh colour, otherwife brown ; and the uvea is fpread with a good deal of a black paint, with- out which it is naturally white. In the uvea, at fome dihance from the pupil, they frequently form an im- perfeft circle. 527. But from the fame ophthalmic and its trunk, or from the lachrymal branch, or from one of the ciliari'es,one or more branches enter into the optic nerve ; the prin- cipal central artery of the retina penetrates through the medulla of the nerve, and, going out of the apex of the papilla (5 1 o.), divides in the centre of the retina ; from thence fpreading every way in company with the retina itfelf, by lb many branches, when traced by a fkilful a- natomift, that that vafcular net-work is taken for a pro- per membrane. Sometimes a lelfer branch goes along the centre of the nerve to the retina, and is in like manner ramified through it. It is certain, that from thefe branches the minute pellucid ones of the vitreous tunic are produced, as well as the pofterior artery of the lens. The centre of thefe arteries, entering the re- tina, is the celebrated opticus of the ancients. 528. The veins of the eye, in general, arife from the ophthalmic vein, which here comes from the vein of the face ; and, going out of the bony orbit, is infcrted into the cavernous fmus. The internal veins of the eye are fewer in the middle of the fclerotica, which they perforate with larger trunks, and form bulhes or trees of a roundifh figure, which commonly keep the middle of the bafis of the tunica choroides ; fome of them, which are long, reach even to the origin of the uvea : others, in the fore-part, are fimilar to arteries : another central vein, like an artery, goes to the retina of the optic nerve. The pellucid or watery velTels dif- fer not in their courfe from thofe which convey blood. There are alfo lymphatic velfels faid to have been feen by fome in the retina ; but the obfervation has not been often enough repeated for us to depend on it. 529. So far with refped to the anatomy of the eye j but Chap. XVII. SIGHT. 27? but that the acHon of this organ lies wholly in the re- ception of light, excepting only a few doubts, appears very plainly from phyfical and mechanical experiments. Light then is a matter either the fame with, or very nearly approaching to, that of fire ; extremely fluid and fubtile, penetrating through all even the hardefl; bodies, without receiving alteration from any length or diflance in its courfe ; moving with fuch a very great velocity, as to run through the diflance between the fun and earth in the fpace of about eight minutes and thirteen feconds. The light we have in our atmofphere proceeds either from that of the fun, whofe body feems to have the power of impelling to us, in right lines, the matter of light, which is confufedly fpread around ; or elfe it pro- ceeds from fome other ignited point or lucid body ; from whence the rays fpread every way, as from a cen- tre to all points of a large fphere, fo as to fall upon the furfaces of bodies ; from whence again it is refleded into the eye, from the enlightened furfaces, in angles equal to that of their incidence, fo as to render the bo- dies from whence it thus flows to the eye, both vifible and of fome colour. 530. It is now fufficiently evidenced from experi- ments, that light is compofed of rays in right lines, al- moft without any phyfical breadth or thicknefs ; and yet, that each of thefe rays is again feparable into fe- ven other permanent and immutable rays of a leflTer kind. The known properties of thefe rays are, that all of them, conjoined together, conflitute a white beam ; which, being refraded by the minute furfaces of bo- dies, are fubdivided into rays of a red colour, which are more conftant or permanent, hard, and lefs refrangible j next to which follow thofe of an orange, of a yellow, green, blue, and indigo or violet colour ; of which thofe are always weaker and more refrangible, which are farther diflant in order from the red rays. A flia- dow arifes from a deficiency in the refleded rays. Thofe primitive rays, varioufly compounded together with fliade, make up all the variety of colours. 531. The 2 So SIGHT. Chap.XVIL 531. The colours, then, which feem proper to bo- dies, arife hence ; that the minute furfaces of their con- ftituent folid particles, by which their pores or vacui- ties are limited, do, according to the difference of their thicknefs, denfity, &c. refled or feparate the rays of light, fo as to fend more of one kind or colour to the eye than another ; whilfl mofl part of the remain- ing rays are lofl; by repeated reflections within the pores of the fubitance: fo that the flrongefl and thickeffc particles reflect a white colour ; thofe next in denfity and fize, a red colour ; till at lalt the minutefl furfaces refled a violet colour. Thofe bodies are opake, which retain the rays within their fubflance, without permit- ting any to pafs through them : which feems to follow from the largenefs and the number of the pores, to the fides of which the light is attraded ; which pores are filled with fome matter that has a power of refradion, different from that which the light fuffers from the parts of the body itfelf. Thefe principles we embrace, till a new theory that places the diverfity of colours in vibrations of different celerities fhall be better efla- bliflied ; neither is it our bufmefs to concern ourfelves with this matter. 532. Thefe rays, falling obliquely upon the furface of liquors of various denfities, pafs through them with a change in their diredion, by varioufly receding from or approaching nearer to a perpendicular : and this is called their refradion. In general, the denfer the me- dium, the more are the rays bent towards the perpen- dicular ; excepting only inflammable liquors, which, by a peculiar property, draw the rays more to a per- pendicular than in proportion to the denfity of the li- quor. The proportions of the angles of incidence to thofe of refradion are obferved to be conftant enough ; fo that the fine of the radius of refradion from air in- to water is to the fine of the angle of incidence, as 3 to 4 : and in the radius, paffmg from air into glafs, the fine of the incidence is to that of refradion, as 17 to 1 1 j and from water into glafs, as 5 1 to 44. 533. Rays, Chap. XVII. SIGHT. 281 533. Rays, which come through the air with but little divergency, (as do thofe of the fun on account of their immenfe diftance ; or . as, in general, do any rays that come from the diftance of above loo feet), falling out of the air upon denfer bodies, fpherically convex, are refleded to greater angles, as of 48-I degrees ; nor are they under that meafure. If the angles are fmall- er, and they penetrate the refrading medium, they are there fo refraded, as to meet together in one point, which is called their focus. This point always falls within the axis or radius that is perpendicular to the furface ; whence it becomes permanent and unchange- able. So that the focus of rays, paffing from air into a fphere of water, will be diftant from the axis one femi- diameter of the fphere ; and in a globular glafs, it will be diftant a fourth part of the diameter ; but in a convex lens of glafs, that is part of a fphere not lefs than thirty degrees, and equally convex, the focus will be likewdfe diftant one femidiameter ; yet fo that the rays will meet, not in a Angle point, but in a little circle. 524. Therefore the rays of light, whether dlred or infleded, fall in fuch a manner upon the tunica cornea of the eye, as to form a moft fharp cone betwixt the lucid point and the membrane upon which they are fpread : the bafts of which cone will be the furface of the cornea, and the apex in the radiant point ; yet fo that all rays in this cone may, without any fenftble er- ror, be reckoned parallel with each other. Among thefe, there are forae rays refleded back from the cor- nea, without ever penetrating the furface ; namely, all fuch as fall upon that membrane in a greater angle than that of forty degrees. Others, which enter the cornea at very large angles, but lefs than the former, and fall in betwixt the uvea and ftdes of the cryftalline lens, are fuffbeated or loft in the black paint that lines the uvea (512.) and the ciliary procefles (5 14.) ; but thofe rays only fall upon the furface of the lens, which (enter the cornea, at fmall angles, not much diftant from 202 SIGHT. Chap. XYll. from the perpendicular, or at mofl; not exceeding twenty*eight degrees. By this means, all thofe rays are excluded which the refracl:ing power of the hu- mours in the eye could not be able to concentrate or bring together upon the retina ; without which they would paint the objecl too large and confufedly. 535. Thofe llender rays, therefore, coming thus to the thick cornea, w'hich is denfer than water, and forms the fegment of a fphere, fuifer thus a greater power of refraftion, and pafs through it in a more confiderable degree towards the perpendicular ; namely, about a fourth part : but thefe rays falling with but little con- vergency upon the aqueous humour, which is finall in quantity and almoft like water, making there no fo- cus becaufe of the nearnefs of the humour to the cor- nea, go on nearly parallel, or little converging, to the next adjacent furface of the very pellucid or cryftalline lens; becaufe their divergency was confiderably cor- reded by the refrading power of the cornea. More- over, the cornea, being convex and part of a lefs fphere than that of the fclerotica, receives and collects a greater number of rays than if it was flatter with a lefs furface. 536. The refrading power of the cryffalline lens, which exceeds that of water, may be underftood from its greater hardnefs and w'cight ; although we have no certain meafure. In this lens therefore, and more ef- pecially in its pofterior very convex fide, the rays will converge much together, and pafs thence into the vi- treous body. 538. This vitreous body is denfer than water, in which it finks to the bottom ; but rarer than the cry- ftalline lens ; and continues to bend the ravs a little more gently towards the perpendicular, til! at length the rays, coming from the point of diftind vifion, are concentrated into a very fmall part of the retina, where they paint an image of that objed from whence they come ; but in a pofition inverted, from the neceffary 4 ecufTation or crofling of the rays. The manner in which Chap. XVII. SIGHT* 283 which the images of objects are thus painted, may be feen experimentally in an artificial eye, or by a natural eye when the back-part of the fderotica is cut off, and a piece of paper placed to receive the objed. But the image we fee is painted on the outer fide from the op- tic nerve, within the bounds of the vifual axis; yet fo that it is not a mere point, but has fome degrees of breadth ; fince we fee many objects at once, whofe images mufl: be in di'dinct points of the painted field. And there an objeft is feen moil diftindly, becaufe the rays arrive thither nearly perpendicular. But fre- quently this point of vifion does not fall on the fame place in both of the eyes. When the lens has been couched or difplaced, the vitreous body, with a weak- er refracting power, ufually fuffices to bring the vifual rays together to a focus. 539. Is it altogether falfe that the object is painted on the retina ? Or is this picture made on the choroi- des ? Is this new opinion confirmed by an experiment, by which it is found that the place where the optic nerve enters is blind ? and which is thus explained, that there is in that place no choroides but the bare re- tina, and that thence there is no vifion. But this is repugnant to a very well known obfervation, namely, that the retina is a niofi: fenfible nervous medulla ; and that the choroides confifls almofi; entirely of a few fmall nerves, and of veflels moll certainly blind. This is likewife contradicted by the very great variety of the choroides in animals ; the equally great conliancy of the retina ; and the black fpots, which, even in man, obfcure the exterior furface of the retina. But by this experiment we know the reafon why the optic nerve is not inferred into the axis of the eye, but into its fide. For thus, except only in one fingle cafe, where there is an impediment in the concourfe of lines drawn through the centre of the optic nerves,- the one eye fees and aflills that whofe blind fide is turned towards the object. 540. But fince the neceflary offices of human life M m require 284 SIGHT. Chap. XVIT, require a diftinft object to be painted upon the retina, not only by the rays which come from one certain di- ftance, but likewife by rays which come from very dif- ferent parts more or lefs diftant; therefore, it is to be believed, that the necelfary change is produced in the eye by its own proper caufes. Other famous ana- tomifts have fuppofed the lens moveable by the powers before mentioned (519. 523.) This art of feeing di- ftindly is faid to be learned by experience, it being unknown to an eye lately couched of a cataraft. Alfo, in an artificial eye, the ufe and neceffity of this motion, it is faid, may be plainly perceived. Therefore too great a divergency of the rays, as in thofe which come from objefts very clofe to the eye, is corrected by a removal of the lens farther from the retina, fo as to bring the focus of the diverging rays upon the retina itfelf, which would otherwife have fallen behind the eye ; for the refracting power of the eye being deter- mined, that which will unite the focus of rays co- ming from the diftance of three feet, fo as to make them fall perfectly upon the retina, will not be able to colledt together into the fame point thofe rays which come from the diftance of three inches j and rays ftill more diverging will meet together yet farther behind the eye, if they are not collected together by a greater refracting power. 541. But thofe rays, which come from parts very remote, and which may be therefore counted parallel, will meet together before the retina, in the vitreous bo- dy ; and again feparate according to the nature of rays from the point of concourfe, as if it was a lucid point : to remedy which, therefore, it is probable that thofe powers (523.) remove the cryftalline lens back from the cornea, nearer to the retina ; that the rays, ^hich come together from a certain diftance to the lens, may be alfo united together at a certain proportionable di- ftance on the retina. For an eye, that will collect the rays coming from feven inches, fo as to unite them on the retina, will colleCl thofe together before the re- Chap. XVn. SIGHT. 285 tina which come from a diftance of three feet. It was therefore perfedlly neceflary for the eye to be made thus changeable, that we might be able to fee diftinft- ly at various diflances. But the point of diftindl vi- fion is in that part of the retina where the given object is painted in the leaft compafs* poflible. The powers caufmg the vifual rays to unite or converge together on the retina, are often very different in the two eyes of one and the fame perfon, fo as to render one eye near- ly prefbyoptical or long-fighted, and the other myopti- cal or fhort-fiffhted. O 542. Thefe and other things fimilar are commonly •received and taught, more efpecially by the mathemati- cians, who more readily perceive the neceflity of thefe changes. But yet there is no power in the human eye which can either move the cryftalline humour out of its place, or comprefs it. But we do not perceive this faculty in ourfelves ; for we move a book nearer to our eyes w'hen it is too far off, fo as to appear con- fufed ; which we would have no occafion to do, if by changing the internal figure of the eye we could cor- rect the fault of the diftance : and, through a fmall hole, we perceive an objeQ: only fingle in the point of diftinft vifion, but double in every other. Perhaps the contradtion of the pupil may do fomething, by w'hich we can perceive more diflindlly fuch objedts as are near. 543. But this artifice of the eye is not fufficient in all perfons : for there are now a greater number of people than formerly employed in a fludious or feden- tary life, and taken up wath the obfcrvation of more minute objedts ; by which the cornea is rendered more convex and denfe, and the cryftalline lens more folid and of lefs fegments ; while the eye itfelf, by the weight of the humours, is more elongated, and the reft of the humours themfelves are probably more den- fified : many or all of which circumltances attend the eyes of one perfon. In fuch, the iris is fenfible in a fmall light ; whence, by winking or (training the eye- M m 2 lids. 226 SIGHT. Chap. XVII. lid, they are denominated ?nyopes, flrort or near fighted. In thefe, the point of diftinci; vifion is very near- to the eye, from one to feven inches from before the cornea; but they fee remoter objects more obfcurely, without being able to diftinguifli their parts. The reafon of this is evident ; fince, from the forementioncd caufes, there is a greater refracting power of the humours, by which the diflant and confequently parallel rays arc obliged to meet in their focus before the retina ; from whence, fpreading again, they fall upon the retina in many points. Thus alfo to a good eye, the fenfe ol objects which are too near the cornea is confufed ; be- caufe the rays coming from thence are fpread all over the retina, without being collected towards the cen- tre. 544. The remedy for this fault in the fight is to cor- rect it in its beginning, by viewing diftant places, by .keeping the eyes from minute or near objeds, and by the ufe of concave glafies ; or by viewing things through a fmall hole, by which the light is weakened. When the diforder is confirmed, the remedy is a concave lens, which takes off a degree of the refracting power in the humours, cornea, and cryfialline lens, in pro- portion as it is more concave ; by which means the fo- cus of rays from remote objects is removed farther be- hind the cornea, fo as to fall upon the retina. This glafs ought to be a portion of a fphere, wliofe diame- ter is equal to the dillance of diftind vifion from the naked eye, fquared by the diftance of diftind vifion in the armed eye^ and divided by the difference betwixt them. Age itfelf advancing, gives fome relief to the Hiort-fighted ; for children are in a manner naturally myoptical : but, as the eye grows older, it becomes flatter, in proportion as the folids grow flronger; and, contrading to a fliorter axis, the converging powers ol the lens and cornea are diminifiicd. 545, Another diforder of the light, contrary to the former, troubles people who are often looking upon very diftant objeds, and is more efpccially familiar and incurable Chap. XVIL SIGHT. 287 incurable in old people. In fuch, the cornea and cry- ftalline lens are flatter, and the humours of the eye have a lefs refrading power. Hence near objects, whole rays fall very diverging upon the cornea, appear con- fufedly ; becaufe the converging or refrading powers of the eye are not fufficient to bring the rays together in a focus upon the retina, but the rays go on fcattered through the retina, and through the point of their pencil behind the eye ; from whence vifion is confufed. The point of diftind vifion among prefbyopi, or old or long- fighted people, is from the diflance of fifteen inches to three feet. 546. Such perfons are, jn feme meafure, relieved by looking through a black tube held before the eye, by the ufe of which the retina grows tenderer, and the rays come to the eye in a parallel diredion. The re- medy here is a convex lens of glafs, which may caufe the rays to converge and unite together fooner in a fo- cus, that it may not fall behind the eye, but upon the retina. The diameter of the fphere, of which fuch a lens ought to be a portion, is determined as before (544.) There is no hope from age, which increafes the malady. 547. The medium betwixt fliort and long fighted is the beft, by which a perfon can fee diffindly enough objeds that are both near and remote ; and of this kind we reckon an eye that is able to read diftindly at the diflance of one foot. But to this are to be added other neceffary conditions ; fuch as a perfed clearnefs of the humours ; a due mobility of the eye itfelf, and its parts ; a fenfibility of the pupil and retina, neither too tender nor too tough. 548. But the mind not only receives a reprefenta- tion of the image of the objed by the eye, imprefled on the retina, and transferred to the common fenfory or feat of the foul ; but flie learns or adds many things from mere experience, whiclr the eye itfelf does not \ really fee, and other tilings the mind confiders or inter- prets to be difierent from what they appear to her by the 288 SIGHT. Chap.XVII; the eye. And, firO:, the magnitude of an object is judged of by an optical angle intercepted ; as the bafts of a triangle betwixt the cornea, and as the point of a cone betwixt the radiant object. From hence, things very near feem large, and remote objefts feem fmall. Hitherto may be referred the power of microfcopes, by which objects are made to appear to us fo much larger, as the diftance of the focus of the lens or magnifter is lefs than the diftance of diftinct vifton ; when, in reali- ty, they do not appear larger, only more diftindt and lucid ; whence the mind judges them to be nearer. 549. The ftrength of vifual light likewife is propor- tionable to the fame angle, in the external day-light ; and the multitude or number of the rays, joined with the fmallnefs of the feat which they affeft in the retina, occaftons near objects to appear brighter, and diftant objects more obfcure ; or if remote objects appear bright by their own light, the mind reprefents them as large, near at hand, or both. 550. The place of a diftant object appearing to one eye, is reckoned to be in a line comprehended by two other ftraight lines drawn to the extremities of the bo- dy. If the fame body is looked upon with both eyes, it will then feem to be in the concourfe ot two lines drawn through the axis of both eyes to that object. 551. Diftance we cannot perceive ; and if a blind man, who never faw, fliould by any means be reftored to fight, he w'ould imagine every thing he faw to touch his eyes. Even we who are accuftomed to judge by fight, make many fallacious conjectures concerning the diftance of objects : but concerning this w'e judge as well from the known diminution of the bulk of the body, as from the lelfer ftrength of the light, and faint image of the object whofe parts we are lefs capable of diftin- guUliing, and from the number of bodies interpofed, whofe diftance is knov/n. 552. The convexity or protuberance of a body is not feen ; but is afterwards judged of by experience, after we have learned, that a body, w'hich is convex to the feeling, Chap. XVII. SIGHT. 289 feeling, caufes light and fliadow to be difpofed in a cer- tain manner. Hence it is, that microfcopes frequently pervert the judgment, by tranfpofmg or changing the fliadows. The fame alfo happens in that phenomenon which is not yet fufficiently underftood, by which the concave parts of a feal are made to fe?m convex, and the contrary. 555. The y\Wo\e fttuation of the parts of an obje£l, are judged by the mind to be the fame with that which they naturally have in the objeft, and not the inverted pofition in which they are painted upon the retina. But it is certainly a faculty innate or born with the eye, to reprefent objeds upright to the mind, whenever they are painted inverted upon the retina ; for new-born a- nimals always fee things upright. And men who have been born with catarafts, without ever being able to fee, are obferved, upon couching the cataracts, to fee every thing in its natural fituation, without the ufe of any feeling, or previous experiences. 554. One thing which impofes upon the mind, is the continuance which external fenfations make, during al- mofl the fpace of a fecond of a minute, after they have been conveyed to the fenforium by the eyes ; whence they are reprefented to the mind as objects really pre- fent. From hence proceeds the idea of a fiery circle from the circumrotation of a lucid body ; and from hence proceeds the continuance of the lliining image of the fun, and fometimes of other bodies, after they have been viewed by the eye. 555. Do we perceive only that obje£l diftinftly which is direftly before that part of the retina which fees moll diftindly ? And does the eye perfuade itfelf, that it fees many objects at a time, partly from the duration of the ideas, and partly from the quicknefs of the motions of the eye ? Concerning the moil diltincl; vihon, this is moll certain ; but we cannot affirm it of that which is lefs dillind. Why do we fee only one objed with two eyes? Becaufe the fenfation becomes one, and without difference, when we have fimilar impreffions of two I 290 SIGHT. Chap. XVU. two objedls. For, even without the concourfe of op- tic nerves, infers who have numerous eyes perceive objefts fingle. Hence the images of two objefts ex- cite only one fenfation, when they fall upon the fame point of the retina ; but two fenfations arife from one object, when the images fail upon different parts of the retina. Whence proceed diurnal and nocturnal blind- nefs ? The former is common to many nations living in the warmeft climates, under the brighteft rays of the fun, and to old men. The other happens in inflamed eyes, and young men of a hot temperament, and hence endowed with eyes vaftly fenfible. Whence do animals fee in the dark? From a large dilatable pupil, and tender retina; a fhining choroides, and one which rcfledts the light very ftrongly. Why are we blind when brought out of a ftrong light into a weak one ? Becaufe the optic nerve, having fuffered the action of ftronger cau- fes, is incapable of being moved by weaker ones. Whence have we a pain, by paffing fuddenly from a dark place into the light? “Becaufe the pupil, being widely dilated in the dark, fuddenly admits too great a quantity of light before it can contraft ; whence the tender retina, which is eafily affected by a fmall light, feels, for a time, an imprelfion too lharp and ftrong. Whether fee we with one eye, or with both ? Moll frequently with one, and more efpecially the right eye : but when both are employed together, w'e fee more ob- je£ts, and more plainly ; and we alfo dUlinguilh more points of the fame object, and judge better of their dif- tances. CHAP. XVIII. Of the Internal Senses. 556. T TITHERT O we have confidered the fenfes XJL as they are, each of them apart. It is now common to them all, that the tender pulp of the nerve, being Chap. XVIII. SENSES. being ftruck or imprefled by external objects, conveys a change by the nervous fpirits, to that part of the brain where the Impreifed fibres of the nerve firfl arife from the arteries (372.) We know nothing more, than that new thougnts are thus excited in the mind : which we call perceptions^ with refpect to the thinking mind her- felf ; and ideas, ysixih refpeft to the objects from whence they arife. Perception is therefore excited whenever any of the forementioned changes, in fome of the fen- fible organs, are transferred to their firft origin ; for the thought or fenfe by which the perceiving nerve itfelf is affefted, is no exprefs image or idea of the objedt. The idea of rednefs has nothing in common with rays but little refrangible, and feparated from the feven portions of which rays of light are compofed ; and much lefs is it confiflcnt with optical principles, for the image paint- ed by rays, upon a foft white nerve, to be conveyed through a mod opaque body, in a long courfe of perfect darknefs, to the origin within the thalami. There is nothing in the pain of burning that can reprefent to the mind its fwift and fubtile matter violently moved, by the particles of which the continuity of the nervous threads is broken or deftroyed. There is nothing in the idea of a fharp found, from a chord of a certain length, that can inform the mind the faid chord trembles 5000 times in the fpace of a fecond. Neither does a fait tafte teach us that the cryflals of fea-falt are of a cubical fi- gure. Again,' though a motion is impreffed on the brain, from the fenfation perceived by the body, the mind neither perceives this motion, nor the tremors of founds, nor the percuffions of the rays of light, but fomething perfeftly diftinct from this motion. But it is eftablilhed as a perpetual law by the Creator, that certain changes, made fird in the nerve, and then in the conimon fenfory, diall produce certain new correfpond- ing thoughts in the mind, which have an indiffolvable conne£liion with each other ;■ fo that, although what we' perceive in the world be arbitrary, yet that it is real, and not falfe, appears plainly from the perpetual agreement N n of igt INTERNAL Chap-XVIII. of fimilar thoughts arifing from fimilar affections of the fenfitive nerves, in all perfons at the fame time, from one objeft, or in one perfon at different times. 557. During the time of our perceptions, therefore, five very different beings are joined together : the body which we perceive ; the affeftion of the organ of the fenfory by that body ; the affection of the brain, arifing from the percuffion of that fenfory ; the change pro- duced in the mind ; and, laftly, the mind’s confeiouf- nefs and perception of the fenfation. 558. It appears from certain experiments, that the firft origin of every perceiving nerve is always diftincl; and that the change which is firfl; excited by the exter- nal objeft in the faid nerve (556.) continues in the ori- gin of that nerve for a confiderable time ; and alfo that thofe changes are fo claffed and laid up within the faid part of the brain, that thofe are neareft together, which were either contemporary, or nearly fo, or which have fucceeded next in courfe; or laflly, which have a rela- tion to the fame fubjeO;, or were excited by fimilar ob- jedls ; infomuch, that it is certain, new fpecies or ideas are always conveyed again to the fame part of the brain where others of the like kind are referved : for other- wife the arbitrary figns of words and letters would ne- ver be able to renew the fame old ideas again in the memory ; nor could difagreeable ideas, returning into the mind, without the affiftance of external objedts, re- produce the fame effedts, as would the difagreeable ob- jects themfelves ; nor, otherwife, could there- be fo con- ftant and manifeft a connection of analogous ideas, which moft powerfully occur in dreams, according to the corporeal caufes which then remarkably a£l in the brain. Whether or no do imagination and memory depend on this confervation of ideas ? Finally, thofe changes in the fenforium, which many term part; or referved ideas, are, for diftiiuffion’s fake, by us cal- led the footjleps or traces of things, which are lodged or engraved not in the mind, but in the body itfelf, by certain notes or charaO:ers, incredible in their minute- nefs. Chap. XVIII. SENSES. 293 ncfs, and infinite in their number, recorded after an in- expreflible manner in the medulla of the brain, A-. mongft thefe charafters, fuch are more eminently and diftindly preferved as were received, firft by the fight, and next by the hearing ; for thofe of the other organs are more confufed and irrevocable by the will. And both the traces and their figns are preferved ; the latter more eafily; the former, however, fo far, that a painter can eafily exprefs with his pencil upon canvas, an image of a face fimilar to one which he is accuftomed with, and which is impreffed on his mind. 559. Imagination, then, is whenever any fpecies, preferved in the common fenfory, and in prefent per- ception, excites fuch other thoughts in the mind as would arife if the perceiving nerve that gave the firft birth to the faid fpecies was itfelf affeCled or changed. This definition is confirmed by examples of the great ftrength of fancy in certain perfons, and thofe who are delirious ; but in every body, in the inftance of dreams, in which thoughts arife in the mind, occafioned by the corporeal fpecies referved in the brain, fo as to be not at all weaker than thofe which were firft formed by the chang^'in the fentient nerve, from the external objedts. Even more, the attention and reft of the mind, with the abfence of all external objedts, will often obtain a ftronger alfent from dreaming, towards the traces im- prcfled in the brain, than that which is given from the mind by the perceptions which are excited from exter- nal objedls : for the will is more powerfully determined in thofe who dream, than in thofe who are awake, fo as often to perform certain adlions by the voluntary mufcles, while they arc aflcep, which they never can perform aw’ake, even though the fame nerves were more ftrongly affedfed by the real objedls. From hence we may underftand, how it is poflible the inter- nal fpecies, which are very ftrong in a delirium, may fo impofe upon the mind, as to make her miftake them for the perceptions of external objedls ; as, for example, in the fiery fparks which are excited by prefling the N n 2 eye <194 INTERNAL Chap. XVIII. eye and optic nerve ; in the rednefs feen by the eye .when it is fhut; in the vertigo or rotation that arifes from a motion of the retina, which we aferibe to the the external objedls themfelves ; in the duplicity of f]ght, &c. 560. But memory is, when any internal former thought of the mind, or the fpecies perceived and pre- ferved in the brain, from external objects (372.), re- peat or excite again other perceptions in the mind. And here the perceptions are commonly weaker than in the imagination, being almoft only certain arbitrary figns conjoined together, with the idea that was firlt perceived in the mind : for the memory hardly repre- fents the images and pictures of things to the mind ; only the words or figns, and certain attributes, together with the general heads of ideas ; lor which reafon, they move the will with lefs force ; but it appears from the obfervation of thofe changes which happen in the me- mory, that fuch as arife Irotn the external fenfes, re- main longed in the brain ; and fometimes, if they made a drong imprellion, they may for ever, and in all ages pf life, be repeated to the mind ; but they arc weaken- ed, and in a manner blotted out in time, by degrees, unlefs the reprefentation be renewed again to the mind, either from an external objedt, or from the mind itfclf recalling the fame change again into memory : fo that, without this repetition, at lad the change or imprefliori will be in a manner erafed and quite lod ; and will never be able to be drawn in again to the mind, whenever die repeats fuch other thoughts as had naturally any connection with the former. This de- drudtion of new and different fpccies, conveyed to the fenforium, is evident, not only from th,e effect of time, but likewife from cataleptic diforders : which fometimes, after a confiderable interval of time, go on with the fame train of thoiuTht which the difeafe O had interrupted. But fometimes all of them will be fuddenly dedroyed by difeafe, in which the brain is any lipw comprefled, eithfr from the blood or other caufes. Chap. XVIII. SENSES. 295 Such a compreffing caufe, afting on fome part of the common fenfory, blots out a cprrefponding number of the fpecies.froin the mind or memory, whether they be certain or all kinds of words, or even the charaSers by which we exprefs words ; or, laftly, the characters of our friends, and necelfaries of life : yet all thefe fpecies are often again renewable to the mind, whenever the compreffing caufe is removed. But the Iirength and duration of an idea depends upon its being either un- ufual, of a ftrong aCfion, or greatly conducing either to increafe or leflen our felicity ; or, laftly, from being joined with great attention from the mind, and often repeated : all which circumftances being conjoined, may render the fpecies fo ftrong to the mind, that ffie will afterwards receive the perception of them, as if they came from external objects, in the manner we ob- ferve in mad people. 561. Moreover, if we review the liiflory of human life, it will appear, that in the beginning of our infancy, we have hardly any memory ; only fimple perceptions, that foon vanilh ; which, neverthelefs, do for the pre- fent excite ftrong thoughts or impreffions in the mind, as we learn from the clamours of infants. But, after- w'ards, /he memory is perfected by degrees, and the ideas received from perfons moft beloved and familiar to the infant remain imprefled in the mind ; while, at the fame time, the imagination likewife increafes in proportion, fo as to be often very pow'erful in young children ; as we fee, for example, in frights, which in no age producp more violent or fatal effeCts, From thence forward, as the number of our ideas in- creafes, the faculty of preferving thofe paft, weakens ; and, at the fame time, the power of the imagination is more torpid or fluggiffi : till at laft the former almoft pe- riffies, and the ideas, which are received but a ffiort time, efcape from the brain ; while, at the fame time, the imagination, which is a kind of memory, languiffies in proportion. 562. But fince the perceptions thus formed in the mind, produce INTERNAL Chap. XVIR. produce in her various changes, which are perfedly free, and diftind from any corporeal faculty, we fhall briefly add fomething concerning them, fo far as may fuffice to the purpofes of phyfic. The office of cogita~ tion in the foul, is to attend to the fenfations which arc either brought by the fenfes, or recalled by the imagi- nation ; frequently alfo to the figns alone which recur into the mind. Attention^ then, is fald to operate when the mind obferves one and the fame idea alone, and for a longer time together. The comparifon of two or more ideas brought to the mind, is called reafon; as the fimilitude, diverfity, or relation perceived by the comparifon, is judgment. The principal caufe of •wlfdom and. invention lies in a flow examination of the ideas, confidered in the relation of all their parts one to another in the mind, while, negleding all other objeds, fhe is employed with a flrong attention only upon that which is under examination. From hence proceeds that efficacy of folitude and darknefs in making difficult calculation ; with the more exquifite attention of blind people to the nature of founds ; and of thofe who are deaf, to colours. The fource of error, is fome negled in contemplating the whole idea, or the making an efli- mate of it from only a part of its note or charader, or from a lefs congruous connedion of fome ideas with o- thers that arc diftind, but only related by accident, external caufes, or affedions. 563. The integrity or foundnefs of the judgment depends upon a perfed and healthy conftitution of the brain. For the fabric of the encephalon being chan- ged, either by compreflure, irritation, or a deficiency of blood, confounds all the ufe of reafon ; occafions the flrong internal fpecies of the brain to be reprefent- ed to the mind as if they came from external or real objeds ; breaks the connedion of the ideas, fo that the mind cannot compare them together ; and is con- fequently unable to judge of, or forefee, their propor- tions, differences, or confequences ; darting imme- diately from one idea to another that has no kind of rela- SENSES. Chap. XVIII. 597 relation; or laftly, the aftions of the fenfes being either weakened or abolilhed, and the brain in a manner de- prived of its corporeal fpecies, the man is reduced to the date of an ideot or a plant. But the powers of external bodies alfo have a confiderable influence in changing the fpecies of objeds, which the mind ac- quires by the fenfes ; for the air, way of life, food, and cudoms, either help or diminifh the foundnefs of the judgment, the force of the imagination, and the drength of the memory. 564. Finally, as thefe ideas are either indifferent to us, or elfe conduce to the lofs or increafe of our feli- city, fo they produce different determinations in the %vill. Some of thefe ideas, by which the felicity of our mind is either increafed or diminifhed, arife merely from the mechanifm of the perfed body ; and amongd thefe corporal pain is a forrowful fenfe or perception in the mind, to which every violence or over-drong fen- fation in any nerve feems to ferve as a foundation ; while pleafure confids only in the nerve’s being irritated beyond what is ufual, but in a moderate degree. Itching dands related to pleafure, inafmuch as both of them have an increafed flux of blood into the parts in which either the pleafure or the titillation is per- ceived ; but, when increafed, it tends towards pain, or to an over violent fenfe of the nerve. Anguifh or anxiety is from an over didenfion of the veffels, be- caufe the blood is hindered from paffmg freely through the lungs. The other ideas with which the mind is affeded, are either wholly abdraded from the proper- ties of matter or body, or are at lead much lefs fnnple than the foregoing, which arife either from fenfe or mechanifm. The perception of good ideas excites joy ; the defire of polfefling good excites love, as the expedation of it is the caufe of hope : on the contrary, prefent evil caules forrowfulnefs, terror, or defpair ; the defire of fliunning evil excites hatred ; and the ex- pedation of a future evil excites fear. Hope, curio- fity, and glory, feem to be affedions of the human mind, 2 p8 INTERNAL Chap. XVIIL mind, which neither belong to the body, nor are to be found in beads. 565. From thefe affections of the mind, the mere will appears not only to be determined to fome lore- feen parpofe, to which it directs the actions of the bo- dy, in order to poflefs good and avoid evil j but alfo in the body itfelf, unconfulted, "and making no great reffftance, it exercifes an equal dominion over the puife, refpiration, appetite, ffrength, affedions of the heart, nerves, and ftomach ; with the changes which arife in the other parts, ferving as figns of the pafiions in the mind, from which they immediately fofow. Thus anger excites a violent motion of the fpirits, caufes a a palpitation in the heart, a frequency of the puife, a greater ffrength of the mufcles ; urges the blood into the fmaller pellucid and improper velfels ; and, laffly, haffens the expulfion of the bile from its veffels ; by which means it frequently removes obffrudions, or eafes chronical difeafes. Grief, on the contrary, weak- ens the ffrength of the nerves, and the adion of the heart ; retards the motion of the puife ; deffroys the appetite and digeffion ; whence it produces a palenefs, cachexy, diarrhoeas, jaundice, fcirrhofities of the glands, and other flow difeafes, ariffng from a ffagnation of the humours. Thus, alfo, fear fo much diminifhes the force of the heart, as to occafion polypufes, palenefs, and weaknefs of the mufcular motions, a palfy or relaxation of the fphinders, an increafe of the inhalation of va- pours, but a diminution of thole difcharged by perfpi- ration. Terror from a prefent evil, will alfo increafe the ffrength to fo great a degree, as to caufe convul- fions and a ffrong puife ; whence it fometimes removes obffrudions in palffes, or, by intercepting the courfe of the blood, it kills fuddenly. Love, hope, and joy, promote the perfpiration, quicken the puife, and give the blood a free circulation ; whence thev increafe the appetite, and render difeafes curable. But excef- five and fudden joy often kills, by increaffng the mo- tion of the blood, and exciting a true apoplexy. Shame, Chap. XVIII. SENSES. 25.9 Shame, after a peculiar manner, retains the blood in the face, as if the veins were tied ; it will alfo fupprefs the menfes or other fecretions, and has been even known to kill. 566. But in what manner are thefe changes pro- duced, from the commotion of thofe pallions in the mind ? Do not the nerves cover the velTcls like fphinft- er mufcles, fo as, by contracting them fuddenly, to increafe the courfe of the blood, or, by relaxing and weakening their tone, retard and vitiate the circulating juices ? That this is the cafe in the fmaller yeffels, ap- pears evidently from the near fimilitude of effects in fear and cold upon the nerves of the fldn. Eut in the genital parts, from a conflridtion of the veins, under particular circumflances, we perceive that the blood is manifeflly collefted or accumulated in the parts : and it is no lefs. probable, that, even in the larger veffels, the nervous bridles with which many of them are fur- rounded produce the fame effects : for thus, in feveral parts, they furround and include the meningal, tempo- ral,^ vertebral, carotid, fubclavian, cceliac, mefenteric, renal, and other arteries. But after it is fhewn by our experiments, that the nerves are at reft during the action of the mufcles, nor can be rendered fhorter by any irritation, we muft defert this elegant theory. Nor does it feem far from the truth, that the arteries are rendered more or lefs irritable from the various fenfibility of the nerves, and thus may be contrafted more vehemently or languidly by the fame quantity of blood ; and thus the motion of the blood is either quickened or flackened, if it is at all certain that the fmaller arteries have the fame irritable nature which is common , to the large ones. And thus it is that the appetite and periftaltic motions of the alimentary tube are manifeflly deftroyed or depraved by the paf- fions of the mind. 567. Nor is it to be denied, that the Creator has affxed certain chara6terlftic marks or evident figns to the paflions of the mind, that in mutual fociety one O o man gao INTERNAL Chap. X\TIL man might not impofc upon another. For the refpeC' tive mufclcs, more efpecially of the voice^ face, and eyes, do naturally exprefs the feveral paflions of the mind, fo faithfully, that they may be even reprefcnted by a painter. To run through them all would indeed be an elegant theme, but too long for this Compen- dium. From the atfions of thefe inufcles, often re- peated by the alFedfions, follows the features or phy- fiognomy of a perfon’s face, which is a perpetual in- dex to the ftate of the mind, and retains fomething of the afliion of the prevailing mufeles fo that the ap- pearance of anger often remains in the countenance, after the paflion itfelf is gone off. 568. From whence proceeds the confent of parts^ which is fo famous and often repeated by writers on the pradlice of phyfic? Some of them appear to de- pend upon the conjunction or inofculation of the blood- veffcls ; by which the blood, being driven out of one, is more ftrongly urged into another veffel, which has its branches from the fame common trunk. Hitherto belong the revulfrons made by blood-letting, the pains of the head, which enfue from a cold in the feet. See. In other parts, the confent arifes from a fimilitude in their fabric, by which they fuffer like effedls from the fame caufes in the body : hitherto we refer the confent that is betwdxt the womb and the breafts. Another caufe of this confent is, a continuity of the membranes, ex- tending from one part to another : from hence a Hone in the bladder excites an itching in the glans of the penis, a diarrheea cures a deafnefs arifing from a de- fluftion. Another caufe of confent lies in the nerves themfelves, and their anaftomofes or communications one with another, as appears plainly from the teeth be- ing flupified or fet on an edge by certain founds, be- caufe the various communications which the hard portion of the auditory makes with the maxillary nerve transfer the difagreeable fenfe to the latter. Thus alfo, the fympa- thy of the eyes, which is not obfervable in like manner in the ears, proceeds from the mutual conjuntlion of the optic CHAP.XVm. SENSES. gef optic nerves within the fkull ; and thus a ftone in the kidney excites vomiting. Laftly, the confent may proceed from fome caufe afting on the common fen- fory, and beginning of the nerves, whence the irrita- tion of a Tingle nerve manifelUy excites ample convul- fions, fpreading through the other parts ; fo an univer- fal epilepfy will proceed from a local diforder, &c. A confent is obferved, in fome difeafes, from a tranflation of the matter of a difeafe by filtration through the cellular fubftance of one part to another ; and another kind proceeds from the incumbent weight or a£lionsof the adjacent mufeks and arteries. 569. But there is flill another remarkable confent to be explained betwixt the body and the mind. For that the nature of the mind is different from that of the body, appears from numberlefs obfervations ; more efpe- cially from thofe abftraiQ; ideas and affections of the mind which have no correfpondence with the organs of fenfe ? For what is the colour of pride ? or' what the magnitude of envy or curiofity ? to which laft there is nothing fimilar in brute animals ; neither can that hap- pinefs which is defired by it, viz. the glory of new ideas, be referred as an acquifuion to any corporeal pleafure. For is it poflible, that a body can acquire -two kinds of forces, by the uniting of an infinite num- ber of fmaller parts into one mafs ; each of which fhall not only preferve their own particular properties and affeCfions, and reprefent themfelves, but alfo join together into one confeious whole, differing from all the charaCferiftics of its component parts, and yet be capable both of perceiving and comparing the attri- butes of thofe parts ? Is there any one inftance of a body, which, without an external caufe, can, like the mind, pafs of itfelf from reft to motion ; or is there any body that can change the direction of its motion, without the action of fome other caufe ? Let thofe con- fider who have well obferved the voluntary aCtions of •the human body from the mind. 570. Yet the mind, however different from the na- (5 o 2 tui e 302 INTERNAL Chap. XVIII. nature of the body, is clofely tied to the fame, under certain conditions : fo that (he is obliged to think upon thofe fpecies which the body offers to her perception ; and again, fo that die cannot perceive, remember, nor judge, without the ufe or reprefentation of thofe corporeal fpecies, which are lodged in the brain ; and again, by her will, is the caufe of the greatefl and fwift- efl motions in the body. 571. Thofe have behaved modefUy who, confefling themfelves ignorant as to the manner in which the bo- dy and mind are united, have contented themfelves with proceeding no farther than the known laws which the Creator himfelf has preferibed, without inventing and fup- plying us with conjectures not fupported by experience. We may be manifefUy excufed in this refpedt, from the obfervation (556.), which is here equally certain as in optics, that the affedtions of bodies cohere with the thoughts of the mind, by an arbitrary relation or con- nedtion ; in fuch a manner, that they would produce other thoughts of a different kind, if the Creator was to alter the figure of the refradfing power, or colours of the parts of the eye. Thus he has eftabliflied a law, which obtains always, betwixt the leaft refrangible rays and the connexion of a red colour or idea in the mind : thus there is a law betwixt the imprefiion of thofe rays upon the retina, and the connedlion which he has appointed of the correfponding thought. Nor need we be more afliamed to confefs our ignorance in the mechanifm of this ultimate law in the effedfs of nature, than we are to own ourfelves unacquainted with the firlt caufes of our being. 572. But it will perhaps be demanded of us. Whe- ther the mind does not govern the whole body ? and whether or no all the motions and adtions in the body do not arife from the mind, as the immediate fpring and principle of motion ? Whether even the motion of the heart, arteries, and refpi ration, does not arife from the niind, confeious and folicitous for the common good Chap. XVIIL SENSES. 303 good of the whole fyftem ? Whether this power of the mind does not appear in the flopping of hemor- rhages from W'ounds, by grumous concretions ; to which add, the force of paffions of the mind,, and the power of the mother’s imagination, in the marking or other blemifiics of infants ? Whether the ab- fence of confcioufnefs in the mind, with refpefl to thefe defedts, be not excu fable, from the known obfcurity of attention which flae gives to the refpiration, the motion of the eye-lids, and raufcles of the eye itfelf, the ear, or tongue ; all which motions, we know’, are effedled by the will, although we know not the organs, nor take any notice of the aftion of the will, when we breathe, look, hear, or even w’alk, while w’e are taken up with other thoughts? Whether or no is it certain, that all bodily motions arife from the mind, on the account of our being unable to find out any other caufe, con- fiantly united to the body, to which we can manifefllv refer them ? 573. There are indeed many reafons which will not permit us to confent to this opinion. And, firfl, the conflruftion and government of the body itfelf appear greatly to exceed all the power and wifdom of the mind. The mind is able to fee but one point diflinclly at a time (555.), and it can think only one thought or idea at once : for if it endeavours to fee two objedts at a time, to contemplate two different ideas together, or read two letters at once, the fenfe of both is immediately confufed, the mind flrays in her reafoning, and makes no right judgment of either object ; infomuch, that be- ing fenfible of this her weaknefs, whenever Ihe endea- vours to make a ferious and diligent inquiry into any object or intended work, flie w’ithdraws herfelf, and (huts up all the ports of fenfe, without taking any im- prefiions either by the fight, hearing, fmelling, &c. or without exercifing any of the voluntary motions of the mufcles. But the mind ought to be capable, not only of infinite thoughts, but alfo diftindt ones, for her to be able to perform and govern fo many hundred mufcles, organSj 304 INTERNAL Chap. XVIH. organs, veffels, and moving fibres, in fuch a variety of ways, and with fo great an exaftnefs, as is difficult to, or even above all the folutions that can be given by the working of geometrical problems : and yet, by this hy- pothefis, the mind, ignorant both of herfelf and of her works, ought not only to be equal to fo immenfe a talk ; but likewife, at the fame time, the muft, over and above thofe works, be capable of contemplating the inofl diffi- cult and abdradfed ideas, without either difturbing her meditations by the cares which concern the body, or neglefting any of her neceflary corporeal offices by the variety of her mental operations. 574. Moreover, if, without being confcious of our will, we are neverthelefs able, by that faculty, to influ- ence the refpiration, the winking of the eyes, &c. and even to be able not only to govern, but alfo to fufpend our breathing, ffiut or dofe our e3^es, and open them again ; it follows from thence, that we never lofe either the confcioufnefs or the ufe of thofe aftions, and con- fequently neither the government of them. But we are able to perform nothing of this kind in the heart or inteftines ; we cannot reftrain the motion of thofe parts when they are too quick, nor excite them when they are too languid. In fuch a number of perfons as inha- bit the world, why do we not meet with fome who can govern the motion of their guts? or why, in all the ages of the world, not one who could govern the con- tradtions of the heart? If cuftom only is the caufe of this unknown power, why does not the mind receive a fenfe of her adion, in moving the heart, after it has ■fiood ftill for whole hours, or even days, in fwoons, in hyfteric fits, and in perfons drowned ? 575. But it is evidently a falfe pofition, that all the motions of the body arife from the mind, without which the body would be an immoveable unaftive mafs : for the force of niufcular contradion, by any kind of fti- mulus, to which the motion of the heart, intefiines, and perhaps all the other motions in the human body are obedient (49iO> i^ot require the prefence of the mind ; Chap. XVIII. SENSES. 305 mind ; fince that power continues a conliderable time in a dead body, and may be recalled again into aftion by mechanical caufes, as heat, inflation, &c. Nor does this power defert the fibres fo long as they continue unflif- fened by cold, although the mind may have been a long^ time feparated from the body by a deftruction of the brain : and this action we fee more evidently in the heart, after that mufcle has been taken out of the body for fome time, fo as to be feparated from any imagi- nable connexion with the mind. 576. As to the blemifhes of infants, we have decla- red in another place, how little that article is to be de- pended on. The adminiftration of the vital motions, in difeafes, is not under the rule of any prudence, but governed ahnofl entirely by the power of ftimulus ; as. we are manifeftly taught from the inoft ancient and only certain praftice, by which wu are direfted to re- ftrain the too great violence of thefe motions in acute and intermitting febrile difeafes, by the ufe of blood- letting, with the poppy, nitre, Peruvian bark, &c. The wifefl philofopher in the world has no more privilege or advantage in the government of his body, than the merefl ideot ; and that even infants fliould build up the fabric of their own body, before they know that they have any niufcular motions, is an affertion fo far from being credible, or even moderately probable, that of itfelf alone it is fufficient to refute the hypothefis. 577. A ready difpofition to the exercife of fenfe and voluntary motion, in healthy organs, is called vigilance or voakefulnejs ; but an indifpofition to fuch an exercife of them, with an inclination to reft, in all the laid or- gans, while they remain healthy and entire, is called fieep. 578. In lleep, the mind either thinks not at all of what Ihe knows or retains in memory ; or elfe lire only attends to the traces of paft objects repofited in the common fenfory (558.), the vivid reprefentations of w'hich excite altogether the fame perceptions as are made by the impreflion of external objedls upon the organs 3 o 6 I N T E R N a L Chap. XVIII. organs of fenfe, by which they were firfl received. Thefe reprefentations of fpecies to the mind are called dr emits ; and happen whenever a finail portion of the brain or common fenfory is, by the refluent motion of the fpirits, kept in a flats of vigilance, while all the re It of the empire of fenfe and voluntary motion is blent and at reft. Sometimes there are certain voluntary motions, following of courfe from the perceptions thus perceived by the mind, fuch asfpeech, or motion of all or fome of the lim.bs, conformable to the nature of •what the mind perceives ; and hitherto are to be refer- red thofe who walk in their flecp. 579. But, during the time of flecp, the motion of the heart, with the diflribution and circulation of all the other humours in the body, are regularly continued, together with the periftaltic one of the flomach and in- teflines ; and, finally, the action of the fpinfter mufcles, with the refpiration, are continued in a like manner. This compolition, in which a certain number of the or- gans are at reft, while others continue their motions, renders a knowledge of the mechanical caufe of fleep fomevvhat difficult to attain. 580. Therefore, in order to make this difcovery, with all its caufes, we fliall confider all the appearances both of fleep and vigilance, and trace them in all kinds of animals; for that condition which appears conflantly to follow from all thofe caufes and appearances, will be the true and mechanical caufe of fleep. Sleep natu- rally follows after the vigilance and labour winch are joined to human life. For when a perfon is awake, there is a continual motion or exercife of the voluntary mufcles, of the parts which guard the fenfes, and of the affections of the mind ; all which continually add a new ftimulus to the nerves, blood-veffcls, and heart itfelf. Thus the blood, by continual motion and triture, changes its fmooth albuminous nature, to a rough al- kaline, and in fome degree putrid, fliarpnefs ; while, at the fame time, its more fluid parts, efpecially thofe fubtile ones which compofe the nervous fpirits, are diffi- Chap. XVIlI. SENSES. 307 pated farter than they are fecreted ; whence gradually enfues both a weaknefs and a wearinefs of the body : and, if the vigilance be continued longer than ufual, there is alfo a feverilh heat, a greater acrimony of the humours, and a fenfible lofs of rtrength. As the night advances, a weight or heavinefs feizes all the large mufcles and their tendons, the mind becomes' unfit for any accurate thought or ftudy, and feeks after reft. ^Hereupon the powers which hold the body ereft, rtirink from their office, the eye-lids clofe, the lower jaw falls down, a neceffity of yawning comes on, the head nods forward, and by degrees we take lefs notice of the external objecls, which alfo affeft us lefs, till at length all the thoughts and ideas are in confufion, and a fort of delirium enfues ; from whence there is a tran- fition to fleep not known to us, v/hich however always precedes fleep. In this natural fleep, which is common to all animals, the caufe feems to be a deficiency of the nervous fpirits, which have been every where largely confumed by the exercifes of the mufcles arid fenfes, in whofe a£lions there is probably a great quantity of this fluid exhaled. 581. A perfect reft or compofure of the mind and external fenfes, with the abfence of all ftimulus or irri- tation in the head and other parts of the body, joined with darknefs, promote and haften the forementioned fteps of fleep, and render it more quiet or pro- found. 582. Again, it is obfervable, that a variety of caufes, which weaken the powers, incline to and increafe fleep 5 fuch as great Ioffes of blood from any caufe, bleeding from a vein, the ufe of cooling medicines or thofe prepared from the poppy, and cold of the external air ; to which add, fuch as call off the quantity of blood flow- ing to the head, as warm-bathing of the feet, a plenti- ful ingeftion of food into the ftomach, which is found to produce fleep in all kinds of animals. 583. On the contrary, again, there are various hot medicines which induce fleep, by exciting a greater af- P p - ffus 3-o8 internal Chap. XVItL flux of blood to the brain ; fuch as wine, alcohol, or vinous fpirits of all forts, but more efpecially when re- folved into vapour, opium, hyofcyamus, the indi- geftible particles of our aliments ; to which add, acute and malignant fevers of various kinds, or elfe fuch things as retard the return of the venous blood, as fat- nefs. All thefe caufes feem to concur in this, that the blood being colleded in the head, compreffes the brain, fo as, in a degree, to intercept the courfe of the fpirits from thence into the nerves. 584. But likewife mechanical caufes produce a fleepi- nefs; namely, a compreffure of the dura mater and brain, whether from extravafated blood, a deprelfed part of fome bone, or a collection of ferous water with- in the ventricles of the brain itfelf. 585. Sleep, therefore, arifes either from a Ample de- ficiency of the quantity and mobility of the fpirits, or a compreffure of the nerves ; but always from a more difficult motion of the fpirits through the brain. 586. This theory is likewife confirmed by the caufes of vigilance : for all thofe things prevent fleep which produce plenty of fpirits; more efpecially warm aroma- tic drinks, which fend plenty of minute ftimulating par- ticles to the head, by which the motion or courfe of the blood is moderately quickened through the brain ; and, being at the fame time more dilated, makes a larger fecretion of fpirits in a given time. 387. Sleep, again, is hindered by cares of the mind, meditation, fludy, and paflions of a llronger degree, with pains of the body and mind ; all which hinder the fpirits from refling in the common fenfory, or urge them fo as to preveht the nerves from collapfing. Therefore, as the former increafe the quantity of the fpirits, thefe caufes increafe their motion. And there- fore, again, the fame conclufions are to be made from hence as before (585.); namely, that the nature of fleep lies in a collapfing of the nerves which go out from the common fenfory. 388. If it be inquired, Whether the feat of fleep be not Chap. XVIII. SENSES. - 309 not in the ventricles of the brain ? we anfwer, that it is not confident with the ample bounds or dominions of deep, which extends itfelf even to fuch animals as have no ventricles in the brain. Whether the vital adions continue to be carried on in deep, as it is only an affeftion of the brain independent of the cerebel- lum ? and what may be the caufe of this difference, by which the animal offices red in deep, while the vital operations are continued? We know not of any other reafons, befides thofe before given, that the vital mo- tions are perpetually dimulated into action, from the caufes urging a neceffity of keeping them from red: (392-) 389. The effedl of deep is a moderation or abater ment of all the motions in the human body. For now the adlion of the heart only remains, by which all the humours are fent through the vedels, at the fame time that all the mufcles and perceiving nerves, with the pad- fions of the mind and voluntary motions, are removed ; by which the courfe of the fpirits was quickened not only to the heart, but to all the other organs, fo as to caufe wakefulnefs (565, 417.) Thus the heart is gra- dually redored from its quick and almod feverifh pulfa- tion, to the dow and calm condition in which we find it in the morning ; the breathing in deep becomes dower and fmaller, the peridaltic motion of the domach and intedines, the digedion of the aliments, the fenfe of hunger, and the progreffion of the fseces, are all dimi- nidied ; at the fame time, the thinner juices move more dowly on, while the more grofs and duggidi are col- lected together, and the fat being poured out is accumu- ' lated in the cellular fubdance ; the vifeid albuminous humour, for the nourifhment of parts, adheres more plentifully to all Tides of the fibres and fmall vedels 5 the confumption of the fpirits, the attrition of the blood, and the quantity of perfpiration, are all diminidied. Thus, while the quantity of the nervous fpirits conti- nues to be fecreted, with a lefs confumption, it is by de- grees accumulated in the brain, fo as to didend and fill P p 2 the gi9 INTERNAL Chap. XVIII. the collapfed nerves, which, both in the internal and external -organs, return again to adion^by the approach of fome fmall ftimulus, by which they are again redo- red to vigilance. Sleep, continued for too great a length of time, difpofes to all the diforders that attend a flow circulation, to fatnefs, drowfmefs, weaknefs, and cachexies j and ;s, at the fame time, highly detrimental to the memory. 590. From whence does yawning attend thofe that are about to go to fleep ? We anfwer. To promote the pafl’age of the blood through the lungs, which is now flower. Whence the firetching of the limbs? To in- creafethe motion of the fpirits, that they may oyer-ba- lance the natural contradion of the mufcles, by which all the limbs are drawn into a moderate degree of con- tradion. If it be demanded. From whence came the unjuft opinion, which has been fo well received, that the motion of the heart becomes ftronger in fleep, and the perfpiration more plentiful ? we anfwer. That the miftake arofe from the increafed heat arifing from the bed-cloaths, by which the perfpirable matter being con- fined, every where conduces to warm, foften, and relax the fkin. But any one that fleeps in his ufual garments, grows colder ; and animals which fleep for a long fea- fon together grow cold externally to the higheft de- gree, as field-mice and hedge-hogs. From whence is it that all animals grow fleepy after taking food ? Not from a compreffure of the aorta, or from a reple- tion of the head with blood j for even animals which have fcarce any brain, fleep after food. Whether or not do the indigeftible particles of our aliments, by pafTmg lefseafily through the brain, and comprefling its medulla, produce fleep of a lefs benign kind ? Whether or not there is a perpetual dreaming, fo as to be infeparable from fleep? and whether this be natural, fo that the mind never ceafes to be without thought, as a confequence following from fenfation ? We anfwer. This does not feein to be the true Hate of nature ; for dreams we judge to be rather referable to difeafe, or to fome fti- inulating Chap.XIX. mastication. ' 3it mulating caufe that interrupts the perfed reft of the fenforium. Hence that fleep refreflies moft where there are no dreams, dr at leaft that where we have no remembrance of any. Hence they are generally wanting in the firft fleep, at which time the fpirits are moft exhaufted, and return in the morning when thefc are in fome meafure repaired. Hence we fee, that in- tenfe cares of the mind, or the ftrong impreffion of fome violent idea received in the memory, hard indi- geftible food abounding in its quantity, with any un- eafy pofture of the body, are the moft ufual caufes that excite dreams ; for they are ufually generated by fome fenfation which, by the law of aflbeiation of ideas, joins with itfelf a whole collection of fpecies having an affinity with that one. CHAP. XIX. Of Mastication, Saliva, and Deglutition. 591. C? UCH hard and tough foods as confift of long parallel fibres, or are covered with a bony fheli or cartilaginous fkin, generally require maftication, to divide them into lefs cohering parts, that they may more eafily yield their nourilhment to the diffolving powers of the ftomach. The more diligently they are fubdivided in the mouth, the more reliffiing and agree- able they become to the ftomach ; the nearer do they approach to the nature of a fluid, and the more eafily are they digefted or affimilated. 592. Therefore moft animals are provided with teeth, extremely hard, :but planted with a root that is indeed bony and hollow ; fince it receives, through a final] hole in the tip or point of each fang, little blood- veflels, and a nerve, which go to form its internal peri- ofteum ; and this whole root, being fixed into a focket of the jaw conformable to itfelf, is, in the upper part mwards its crown, ftrongly furrounded and tied down by 312 MASTICATION. Chap.XIX; by the adhering gum-. But the crown, or upper part of the tooth, placed above the gums, is not bony ; but a peculiar fort of enamel, of a harder, denfer fubftancc, and almoft of a glaffy texture, compofed of ftraight fi- bres vertical with its root, and running together towards the middle. This lad portion of the tooth, having nei- ther periofteum nor veflels, perpetually grinds away, and is as often repaired again by a kind of petrifying juice, that afcends or filters from the cells of the root, by which mechanifm they are therefore fupplied with a great degree of hardnefs, very fit to overcome that of other bodies, and to grind the food with their unequal furfaces. 593. As the materials of our food are various in their texture and firmnefs, nature has accordingly made our teeth varioufly figured. In us, the anterior or incifive teeth are four in each jaw, weaker than the reft, and fixed by a fingle root, upon which (lands a crown inwardly concave, outwardly convex, and ter- minated by a gradual extenuation, like a wedge or chifel, with a redilineal edge. The office of thefe is only, in the fofter foods, to cut thofe which are tougher than the reft into fmaller portions ; fuch as the fibres and membranes of animals and vegetables, with the brittle feeds and kernels of fruits. 594. The fecond fpecies is the canine teeth, which are two only in each jaw, fixed by a longer and llronger, but fingle root ; from whence their crown is extenuated into a cone. Thefe lacerate tough ali- ments, and hold faft fuch as require a longer triturc by the grinders. 595. The third order of the teeth is that of the mo- lares, which in general are compofed of feveral roots, with a quadrangular crown, fomewhat flat furfaced, but more or lefs divided by rocky afperities. The two foremoft of thefe are weaker than the reft, inferred by two, or often but one root, with the furfacc of their crown parted into two ; but the three pofterior gi ind- ers are larger, fixed by three, four, and fometimes Chap. XIX. MASTICATION. 313 five roots, but terminated in their crown by only one furface, fomewhat fquare and flat, but lefs in the lower than upper jaw, and is fubdivided into a number of eminences correfponding to that of their roots. Be- twixt thefe teeth, the moft; compa'dl or bony foods are interpofed and broke, as the more tough 3 bd hard are ground fmaller, while the lower teeth are urged ob- liquely and laterally againfl; the moveable upper ones ; and thefe are the teeth which perforin principally what we are to expert from maflication of food. 596. That the teeth might break or grind the food with due ftrength and firmnefs, the uppermoft are fix- ed into the fockets of the immoveable upper jaw, as the lower ones are into the lower moveable jaw, which is a Angle bone, and fo joined with the temporals, that it may be drawn down from the upper jaws, and pulled up againfl them with a great force ; and may be mo- ved laterally to the right or left, forward and back- ward. Thofe various motions of the lower jaw depend upon the articulation of its oval heads, in which the lateral parts of the jaw terminate, convex or higheft in the middle, and received betwixt the oblique protu- berances of the temporal bones, in a fhallow excava- tion, at the root of the jugal procefs, deeper in its mid- dle; and increafed by a little excavation of the fame kind before the auditory paffage, from which it is fc- parated by a peculiar fiffure. This joint has the freer liberty in moving, and its incrufted cartilages have a longer duration, by the interpofition of a fmall cartila- ginous plate, betwixt the condyle of the jaw and tu- bercle of the temporal bone ; concave in its middle above and below, with rifmg fides, which furround the tubercle of the temporal bone upward, the condyle of the jaw downward, and correfponds to the adjacent inequalities. 597. The mufcles moving the lower jaw, which are weak in man, but very flrong in brute animals, are the temporalis and elevator, arifing from a large part of the fide of the fkull, and from the outward tendi- nous 314 MASTICATION. Chap. XIX. nous expanfion of it the ftellated fibres run together into a tendon fixed to the fharp procefs of the jaw * the jnajfeter elevator, having two or three diftinft parts or lefs mufdes, defcends from the os jugalis and mar- gin of the upper jaw backward into the angle of the lower jaw. Both thefe aft in concert ; but the tem- poral mufcle brings the jaw more backwards, and the maifeter forwards. The pterygoideiis intenius defcends from the pterygoide folTa, and from the palate bone and root of the little pterygoidal hook, with the internal wing, into the angle of the lower jaw, which it elevates or draws to one fide or the other alternately. The pterygoideus externus has a double origin ; one tranf- verfe from the inner wing and adjacent bone of the pa- late, with the pofterior convexity of the upper jaw : the other, defeending, arifes from the hollow tempo- ral part of the great wing of the fphenoides ; thence it proceeds backward and downward into the outer part of the condyle of the lower jaw, \vhich it moves late- rally, and draws forward before the upper jaw. 598. The lower jaw is depreffed, fo as to open the mouth by the digraftric or biventer mufcle, ariiing from an hollow of the mamillary bone ; from whence defeending, its middle tendon is tied by a firm cellular fubftance of a tendinous nature to the os hyoides; and being likewife connefted to the mylohyoideus, and then palling through the divided fibres of the ftylo- hyoideus, it is increafed by another flelliy belly, in- ferted at the fymphyfis of the two halves of the lower jaw, within the chin. Moreover, the mouth may be partly opened by all the other lower mufdes of the jaw, os hyoides, and the larynx, as the geniohyoideus, genio- glolTus, llernohyoideus, llernothyroideus, coracohyoi- deus, and latiflimus colli ; although the latter rather draws the fkin of the neck and face downward than the jaw itfelf. The geniohyoideus and digaftric mufdes have a power of drawing the jaw backwards. 599. The lower jaw is elevated with a great force, fo as to divide the food by the prdTure of the upper and Chap.xix. mastication. 3^5 and lower teeth againfl each other, by the a£lion of the temporal, maffeter, and internal pterygoide mufcles ; the contraction of which appears by experiments to be very powerful, and fufhcient to raife feveral hundred weight. The lateral and circular motions of the jaw upon one of its immoveable condyles are performed by the external and internal pterygoidei, acting either alone or together with the former. Thus the food is cut, lacerated, and ground to pieces ; and if the ma- ftication be continued diligently, it is, together with the liquors of the mouth, reduced into a kind of pulp. 600. The fore-part of the teeth is covered with a cutaneous and flefhy fack, which is every where pro- duced from the integuments of the face ; and miakes a hollow, in which both rows of teeth are fhut up. The fides are called the cheeks^ the middle parts the Ups, From this cavity there lies a paffage, betwixt the teethj into the mouth; which on the upper part is bounded by the bony and foft palate, underneath by the flefliy parts lying under the tongue, and on the fore-part by the teeth. On the back part it opens between the foft palate and tongue into the fauces. The tongue di- vides the cavity of the mouth in the middle, and is eafily moveable to every part of it. 601. During the trituration of the food in the mouth, there is continually poured to it a large quantity of a watery clear liquor, evaporable or infipid, or at leaft but very little faline, and Con- taining but little earth ; neither acid nor alkaline, although from thence may be obtained a very fmall portion of lixivial fait ; of which there are nume- rous fprings in the neighbourhood. A large quan- tity of this faliva is feparated by numberlefs fmall glan- dules of the lips and cheeks, of an oval figure, and fome larger ones which are placed round the mouth of the duft of the parotid gland ; and lafUy, the pores of the hard palate pour out this liquor, which they fe- crete, through a little fliort duil and hole. The juice, Q^q poured 3i6 a L I V a. Chap. XIX. poured out from the exhaling veifels of the tongue, mouth, and cheeks, is of the like kind, or rather more watery. As for the ductus incifivus, we are now fuf- ficiently certain that it is blind, or difcharges nothing into the mouth, only gives palfage to an artery from that of the palate into the nares. 6oJ. The faliva is a watery liquor, w'ith a moderate quantity of fait, partly lixivial, and partly culinary j with fome oil and earth, diffipable by the fire ; with fcarce any tafte, unlefs given to it by difeafe or famine. The quantity produced is very confiuerable, as twelve ounces have been known to flow out from wounds in thofe parts in the fpace of an hour. By good-mannered peo- ple it is for the mofl; part fwallowed ; and ufefully, as it cannot be throwm away without hurting the di- geflion. 603. But the falival glands efpecially fupply the wa- tery humour called after their owm name. Of thefe the principal is the parotid, filling up a large interval betwixt the auditory pafiage and the lower jaw, to which it is immediately contiguous in the part unco- vered and to the maflfeter. It is a conglomerate gland, made up of round or grape-like clufters, connecled by the cellular fubftance ; which lafl, being denfified and reticulated, forms an almofl tendinous covering that furrounds and connects the w'hole gland. Its duel is white, vafcular, and capacious, afeending from the bottom of the gland to the os jugale, from whence it is tranfverfely inclined, and takes in by the way a fmall du(Sl of a folitary glandule on the top of the maiTeter, or elfe lodged diftindl, or continued upon the parotid itfelf, and is rarely double ; after this the duel, bend- ing round the convex edge of the mafl'eter, opens with an oblique or cut aperture, without, a papilla, through the departing fibres of the buccinator mufcle, in the midfl; of many little glandules of the cheek. The bulk of this gland, and the number of its arteries, make it the chief fpring from whence the faliva flows. 604. Another fmall gland, adjacent to the parotid, but Chap. XIX. SALIVA. 317 but twice as little, compofed of fofter and larger ker- nels, connected by the like cellular membrane, is, from its fituation at the lower angle of the jaw, called maxillary ; being in part terminated only by the Ikm, but in part fends off an appendix over the mylo-hyoide mufcle, which, following the long hollow fide ot the lower jaw, of a granular fabric, is fpread under the membrane of the mouth, by the name of fublbigualis. From the larger maxillary, together with this appen- dix, a du£l paffes out, which, being a long way co- vered in its middle part by the fublingualis, receives one, two, or three branches ; by whofe infertion being increafed, it opens into a projecting membranous cy- linder under the bridle of the tongue. But other fmall and fhort duCts from the fublingual gland, from the number of three, four, or more, to twenty ; with fliort little duCts and points in the line continued back- wards from the fmall frenum, perforate the edge of the tongue, and fecrete faliva. There are fome in- flances where the larger anterior branch of the duCl of the appendix, which ufually joins itfelf to the maxil- lary gland, goes on fingle, parallel, and opens by it- felt. Other glands alfo, hmilar to thofe of the cheeks, which likewife may be reckoned among the fublingual ones, by their proper duels perforate the membrane of the mouth where it departs from the tongue. Various other falival duCls have been publifh- ed by different profeffors, which are not confirmed by anatomy. 605. The Creator has wifely provided, that, by the motion of the jaw in maftication, the falival glands fhall be compreffed by mechanical neceflity, fo as to difeharge their juices then to the mouth in greater plenty. For, when the mouth is opened, the maxillary gland, being preffed by the digaflric and mylo-hyoi- deus, throws forth a fountain of faliva ; the maffeter when fwelled preffes the parotid gland, as does alfo the cutaneous mufcle of the neck which lies over it ; q 2 and 318 MASTICATION. Chap.XIX. and it is this mufcular prelTure that excites the appetite, and pours the faliva into the mouth. 606. The food therefore, being in this manner ground betwixt the teeth, and intermixed with the wa- tery faliva and air, is broken down into a foft juicy pulp, pliable into any figure, and replete with elaftic air, which by the aftion of the latter undergoes a far- ther dilfolution, by the warmth of the parts exciting the elafticity of the air to expand and burll afunder the confining particles of the food, betwixt which it is included. In this aft of maftication, the oily, aqueous, and faline parts of the food are intermixed the one with the other ; the fmell and tafte of. different ingredients arc loft in one, which by the dilution of the faline parts with faliva renders the food flavourable : but fuch par- ticles as are more volatile and penetrating, being di- reftly abforbed by the bibulous veffels of the tongue and cheeks, enter ftraight into the blood - veffels and nerves, fo as to caufe an immediate recruit of the faculties. 607. But the motions which are neccffary for turn- ing round the food, applying it to the teeth, and con- veying it through the different parts of the mouth in maftication, are adminiftered by the tongue, cheeks, and lips. And firft, the tongue being expanded fo as to form a fmall concavity in its back or furface, takes up the food thus prepared, and conveys the charge by its moving powers (450.) to the parts for which it is defigned. At one time the tongue, rendered narrow by lateral contraftion, fearches . every part of the mouth with its tip, and turns out the latent food into a heap on its common concavity. At another time, applying its extremity to the fore-teeth, and raifing it- felf up fucceffively, it draws from the cavity ot the mouth the fluids or chew'ed aliments, and conveys them to the fauces or back part of the mouth behind the teeth. 608. But thefe motions of the tongue are likewife governed by the mufclcs and membranes, largely in- ferted Ghap. XIX. SALIVA. 319 ferted into the os hyoides, the bafis of which is inter- nally concave ; from whence are extended horns late- rally and outwards, terminated by more protuberant heads, and completed with little oval cornices ; and this bone being drawn down by its rcfpeftive mufcles, depreifes the tongue at the fame time, and the lower jaw likewife, if the mufcles of that be relaxed. Thefe power's are the Jlernohyoideus, but arifmg alfo in part from the clavicle, extenuated upwards, and ftriped with tendinous lines ; the Jlernothyroideus^ arifmg as the for- mer, and broader from the upper rib ; which mufcle, depreffing the cartilage to which it is inferted, is under a neceffity of pulling down the os hyoides^ to which it is joined : this is partly intermixed with the hyothy- roideus and thyreo-pharyngeus, and every where con- fufed with the flernohyoideus. Next the coracohyoi- deus, arifing from the upper and fliorter fide of the fca- pula, near its notch, afcends obliquely, and at the crof- fing the jugular vein changes into a tendon ; from whence the other belly of the mufcle afcends direfl; to its infertion into the os hyoides, which it depreifes, be- ing every where 'confounded with the flernohyoideus. The hyothyroideus is determined by the former mufcles. 609. The other powers which elevate the os hyoi- des, together with the tongue, are its Jlyloglojffus mufcle, fuftained by a peculiar ligament of the upper jaw. The Jlylohyoideus , a weak mufcle, often fplit for the paifage of the biventer, and again united into one portion, after adhering to the tendinous expanfion of the biventer, is inferted, together with its fellow, into the angle of the bafis, and often into the horn of the os hyoides : the fecond flylohyoidcus, when it is prefent, refembles the former, behind which it is placed ; arifing from the tip of the ilyloide procefs, it is inferted into the fmall oifa triticea, and anfwers the purpofe of a liga- ment to fuilain the os hyoides. All thefe mufcles draw the tongue back, but laterally they elevate it. The mylohyoideus^ arifmg from the whole length of the jaw^, running into one with its companion, elevates the tongue. 320 DEGLUTITION. Chap. XIX. tongue, and fixes it in making various motions, or in like manner depreffes the jaw. The geniohyoideus ^ being a companion of the geniogloflus, pulls the tongue forward out of the mouth. 6 1 o . But, moreover, the mufcles of the cheeks varioufly move and prefs the food in the mouth. Others move it from the cavity of the cheeks into the inner cavity of the mouth behind the teeth, as we fee in the buccina- tor when the mouth is fhut. Others open the mouth for receiving the food ; fuch as the double-headed pro- per elevator of the upper lip, and the elevator which is partly common ; to which add, the zygomaticus, up- per and lower ; the riforius, triangularis menti, and the depreflbr proper to the angle of the mouth ; which arifing from an excavation on each fide, near the focket of the canine tooth, are inferred into the orbicularis of the lips. Others, again, clofe the lips, that the food received may not return out of the mouth ; fuch as the orbicularis of each lip, the proper depreflbr of the up- per lip, and the proper elevator of the lower lip, and that which ferves in common for the elevation of both. Of thefe, more particular defcriptions may be had from profefled fyftems of anatomy. 611. By thefe means the food, ground and mixed ■with the faliva into a foft pulp, collefted from all parts of the mouth by the tongue into the arched fpace be- twixt the teeth, is afterward, by the expanfion and fuc- ceflive preflure of the tongue, conveyed backward be- hind the teeth ; and, in this action, the tongue is ex- panded by the ceratoglofli and geniogloffi, and rendered a little concave by the Ilylogloflus. And from thence it is next conveyed into the fauces. 612. For the tongue being raifed by the ftyloglolTi, and broadly applied to the palate, firft: by its apex, then alfo ini'enfibly by its poflierior extremity, prefles the food fuccelTively towards the fauces, which at that time only afford an open paflage. After this, the thick root and back part of the tongue itfelf, by the forementioned mufcles, and by the ftylobyoidei and biventers carried back^ Chap.XIX. deglutition. 321 backward, preffes down the epiglottis, which ftands up behind the tongue, conneded therewith by numerous membranes, and perhaps by fome mul'cular fibres. At the fame time, the mufcles elevating the pharynx all ad together ; fuch as the biventer, geniohyoideus, ge- nioglolTus, ftylohyoideus, flylogloiTus, ftylopharyngeus, and the other elevators, which now draw the larynx upward and forward, that the epiglottis, being brought nearer to the convex root of the tongue, may be better clofed or depreffed. Hence it is neceflary towards de- glutition for the jaws to be clofed, that by this means the biventer may have a firm fupport ; and, together with the mufcles already deferibed, elevate the os hyoi- des. Thus the epiglottis, being inverted, fiiuts up and covers the paflage very exadiy, into the larynx, over which it is extended like a bridge for the aliment to pafs over into the fauces. 613. By the pharynx we underfiand an ample fltape- lefs cavity, extended from the occipital bone before the great opening of the fleull downward, along the bodies of the cervical vertebrse, covered above by the middle cuneiform bone, the opening of the nares, and move- able velum of the palate, receiving the tongue and la- rynx before, and continued into the oefophagus below. Its Tides are formed by the lower jaw, the cheek, the velum of the palate, the pterygoid procefs, the ffiliform appendix, the tongue, os hyoides, and larger cartilages of the larynx. It forms one foft membranous bag, outwardly furrounded on all Tides by mufcular fibres. Internally it is lined with a membrane continuous to the cuticle, like which it is renewable, but more moift. Outwardly it is joined to the pharynx with a good deal of cellular fubftance, more efpecially in its pofterior and lateral parts. By this ftrudlure it becomes lax and di- latable, fo as to receive all bodies that are preffed by the tongue over the larynx. 614. It is dilated in its adlion (612.) by the powers ferving to its elevation ; fuch as the Jlylopharyngeus, fometimes double, from the procefs of its name ; w hence defeend- 322 DEGLUTITION. Chap. XIX. defcending, it is inferted into the membrane of the la- rynx, under the os hyoides, and into the cartilaginous edge of the defcending thyroideus ; after which, it is broadly fpread through the internal face o'f the pharynx, together with the following. The thyreopalafiniis^ be- ing fpread in the form of an arch round the m.ovcable palate, is from thence extended downwards in two co- lumns, on each fide the pharynx, which form a confi- derable part of that bag, being alfo connedted by broad fibres to the thyreoid cartilage. That the falpingapha- ryngeus is a true or diftincl mufcle, I am ready to be- lieve, rather from the obfervations of eminent anatomifts, than any of my own. As to the cepbalopharyngew. ^ I almofi; dcfpair of finding any, unlefs you will reckon the flrong white plate of the cellular fubflance, which fur- rounds the upper part of the pharynx, for a mufcle. This bag clofely furrounds and follows the drink, on each fide the epiglottis, above the lar)mx, that it may from thence fall into the oefophagus, 615. That the aliments might not regurgitate into the noftrils at the time when they are prelTcd into the dilated pharynx (614.), a moveable velum or palate is interpofed ; namely, from the bony palate anteriorly, and laterally from the pterygoide wings, is continued a moveable velum, compounded of the membranes from the mouth and nares, betwixt which membranes are fpread mufcles and glandules ; being almoft of a fquare figure, and pendulous betwixt the cavity of the nares and fauces, in fuch a manner, that they naturally leave the former open, and form a concave arch towards the mouth : and from the middle of this is extended a fmall portion, pendulous, and of a conical fliape, before the epiglottis, replete with many fmall glands ; which, from its appearance in a difeafed ftate, is called uvula. The elevator of this velum, which is ftrong, arifes from the afperities and plane face of the os petrofum, behind the fpinal foramen ; and from a cartilage of the tube de- fcending inward, does, with its companion, form an arch, which is moveable with the palate itfelf, between the CHAi>. XIX. DEGLUTITION. 32? O j the two plates of the thyreopalatinus mufcle, fo as to brought into a ciofe contaft with the fides of the nares and with the tubes, that none' of the aliment may enter into either of them. But this elevator does not feem to have any confiderabie adion in fwallowing. At this time regurgitation into the nolfrils is prevented by a conftriction of the mufcles of the pharynx, together with a deprelTure of the thyreopalatinus, which then mani- feftly draws the moveable velum downward and to- wards the tongue and pharynx. Add to thefe, the cir- cumflexus palati mollis^ which arifes a little more for- ward from the fame cuneiform bone, from the internal fide of its wings, and from the inner wing, with the cartilaginous end of the tube, broad ; and then, palling through a notch of the pterygoide hook, changes its direflion, and afcends with a radiated tendon through the upper membrane that covers the velum of the pa- late, joins with its fellow, fpreads over the other mufcles, and adheres to the edge of the palate bone. This is able both to open the tube, and to prefs down the moveable velum of the palate. Thus the pharynx be- ing contracted like a fphin£ler, drives down the food, without permitting any part to return back into the ca- vity of the nares. tience, when the velum of the pa- late is vitiated, the aliments regurgitate into the noftrils, and a deafnefs enfues. 616. During this endeavour to deprefs the food by the pharynx (617.), the velum, drawn back and ex- panded over, is pulled down towards the tongue, by the aflion of the palatopharyngei, and by the circum- flex mufcles of the foft palate. Thefe mufcles, toge- ther with the glolfopalatinus, (which lafl; is indeed weak, being received into the lefler arch of the fauces, and here united with its companion into the arch by the velum of the palate, and from thence fent to the tongue,) prefs the velum againft the protuberant root of the tongue, and intercept any return to the mouth and no- ftrils. After there is no further danger of any part falling into the windpipe, the epiglottis is raifed up a- R r gain. DEGLUTITION. Chap. XIX, gain, as well by its own elafticity, as by the elevation of the tongue itl'elf, by which it is drawm forward. Laft- ly, the depreflcd uvula is railed by the azvgos, which arifes from the tendons of the circumflexi niufcles and levator of the foft palate. 617. A little after this follows an attempt to urge the food downward, which is exerted by the conftrictor . inufcles of the pharynx which draw the fore parts to- wards the back, and the mufcies which are partly tranf- verfe and partly afcend into the poherior furface of the pharynx. Of thefe the principal is the pterygopha- ryngeus, arifing from the whole hook and internal edge of the wing, and from the tendon of the circumflex mufcle ; from whence forming an arch, it is extended upward and backward, and, largely furrounding the up- per part of the pharynx, it joins into one with its com- panion, which has the fame name. The mylopharyn- geus, partly continuous w'ith the fibres of the buccina- tor, in the middle betwixt its two adhefions to the bones, arifes alfo in part from an origin of its own, above the laft of the grinding teeth in the lower jaw. Thefe having a courfe almofl tranfverfe, furrounding the pharynx, draw it back towards the fore part. Next to thefe follow the geniopharyngei, afeending in tw’o flrata of obfeure and confufed fibres which originate from the tongue ; next the chondropharyngei, of a trian- gular figure, arifing from the oflicula triticea ; the ce- ratopharyngei, which afcend radiated from half of the horn; the fyndefmopharyngei, arifing from the horn * of the thyreoide cartilage, and diftincl from the former; to which add, the thyropharymgei of both kinds, in- creafed by the fibres of the flernothyroideus and cricc- thyroideus, with the cricopharyngei, the tranfverfe, the afeending, and the defeending. Thefe inufcles ading fuc- cefhvely from above downward, according to their fi- tuation, drive the aliment into the cafophagus. At the fame time, the deprefling mufcies of the larynx, cora- Gohyoideus, flernohyoideus, and fternothyreoideus, draw down the larynx forward, and leffening the capa- city Chap, XIX. DEGLUTITION. 325 •city of the pharynx urge the food downward. Butin •this adlion, as the aliment pafles by the pofterior rima ■of the glottis, the aryttenoidei contrafl: the larynx per- pendicularly. 618. As various dry and rough bodies are frequently fwallowed, it was neceffary for the pharynx to be dila- table, and not very fenfible of pain ; to which end the great quantity of mucus, which is colle6:ed in all parts of the fauces, greatly conduces. Therefore, in gene- ral, betwixt the nervous and innennolt coat of the pha- rynx, are placed a great number of fimple mucous fol- licles or cells, of an oval figure, pouring out their mu- cus through fhort mouths ; of a foft, vifcid, and fome- what watery nature ; but ropy, or drawing out into threads, not without oil, and abounding more with vo- latile fait and earth than the faliva itfelf. Thefe mucous receptacles are mofl plentiful in that part of the pharynx which is immediately extended under the occipital bone, where they are difpofed in a fort of radiated right lines ; and they are likewife numerous about the tonfil towards its tube, where commonly the fecond tonfil on each fide lies, adjacent to the large one, and in that portion of the pharynx which is called falpingopharyn- geus. But there are likewife other flat and circular follicles, feated in great numbers about 'the back part of the tongue, as far as its foramen cmcum (448.) O- ther follicles and pores of the fame kind are every where feated in the pulpy flefh of the palate, where nu- merous fmall glands difcharge fuch a .vifcid mucus. Moreover, the whole furface of the moveable palate is of a glandular nature, like that of the pharynx ; only the follicles and glandular corpufcles are here more numerous and thickly fet together. Nor, laftly, are lacunse wanting, into each of which are joined many fimple glandules. 619. Where the pharynx defcends laterally from the little pterygoidal hook betwixt the two arches of the fauces, namely, between the gloflbpalatinus and pha- ringopalatiniis, are feated. the tonfils, of an oval figure, R r 2 convex 32 ^ DEGLUTITION. Chap. XIX. convex behind, and thick on the upper part, perforated , inward with ten or more large fmufes, which open through the membranous covering of the velum exten- ded over them, and by the preilure of the adjacent mufcles difcharge a great quantity of a mod thick mu- cus from their fmufes. In like manner, the adjacent parts of the nares, and projefting ring of the tubes, and that fide of the epiglottis which lies next to the larynx and the back of the arytasnoide cartilages, are alfo re- plenilhed with mucous organs. Laftly, the oefophagus itfelf, on all fides, abounds with fnnple follicles, from whence a mucus is poured out fomewhat more fluid. But the larger gland ulae oefophagaete are of the conglo- bate kind, and conduce nothing to this mucus. The blood-veflels of the tonfils are fupplied from thofe of the tongue, lips, and pharynx itfelf ; as thofe of the oefophagus are derived from the branches of the pha- rynx, upper and lower thyreoidais, from the bronchiais and aorta. The veins of the palate and tonfils being numerous, run together into a net-work, ending in the fuperficial branch of the internal jugular. 619. The afophagus^ then, is a double tube, of which the innermoft is feparated from the outer bv a good deal of cellular fubftance, that may be inflated. The innermoft tube of the oefophagus is nervous and ftrong, being continued from the membranes of the" mouth and nares, on its inner fide plaited and porous, having an epidermis which is not villous, but pulpy, and exhaling a thin humour ; it is diftinguilhed by a thin cellular fubftance, in which the fmall veffels are reticu- lated with minute glands interfperfed, which are conti- nuous, and fimilar ,to thofe of the pharynx. The outer tube is mufcular, and in itfelf confiderably ftrong, com- pofed of fibres internally continued from the lower and back part of the cricoide cartilage, which, by degrees, change from annular to fibres that are externally lon- gitudinal, and ferve to draw up and dilate the cefopha- gus againft the food, that the mouthful may be re- ceived. But the other internal circular fibres, which Chap. XIX. DEGLUTITION. 527 are ftronger than the former, arife in like manner from the top of the cricoide cartilage ; and by their fuccef- five contraftion againft the food, drive it down through the whole long tube of the oefophagus, which defcends firfl; in a direft courfe, a little to the left fide of the windpipe ; but having reached the cavity of the breaft, it paffes behind the heart, through the cellular interval that lies behind the bag of each pleura (77.); from whence, inclining by degrees a little to the right, it af- terwards bends again forwards to its proper opening, by which its included food paffes through the dia- phragm ( 7 . 62 .) in the interval of time that is betwixt exfpiration and infpiration. Outwardly, the whole tube of the oefophagus is furrounded by the cellular fubftance, by which it is loofely tied to the neighbour- ing parts. 620 . The aliments are moved through the oefopha- gus as through an inteftine. The longitudinal fibres, afcending to the cartilages of the larynx, dilate the gul- let, oppofite to the defcending morfel. But when it is received, the longitudinal fibres equally dilate and ele- vate the gullet at that place which receives it. Then that part of the oefophagus where the morfel is feated, being irritated, contrads, and moves the food down- wards. The mufcle is ftrong, and very irritable. 621 . This upper opening of the ftomach is con- tradled or corapreffed in fuch a manner, by the lower mufcle of the diaphragm, in every infpiration, as to confine the food within the ftomach, and diredl it in every refpiration, by preffure, naturally towards the pylorus. By this means, the ftomach is fo clofely lliut, that in the moft healthy man even wind or vapours are confined within the ftomach ; nor do they ever afcend but by a morbid affeftion. chap. STOMACH. Chap. XX. g2S CHAP. XX. Of the Action of the Stomach on theYoon. ^2 2.T> Y the fomach we underftand a membra- JL# nous bag, deftined for the reception of the food ; ^ placed within the cavity of the abdomen, behind the lower diaphragm and left falfe ribs j in general of an oval figure, or like a cafk ; of a larger diameter tranfverfely, and this more fo as the pcrfon is more adult ; but in the fetus it is altogether fhort and round. But if we confider more accurately every feftion of its figure, thev will appear circular ; although there be a blind or obtufe concavity in its left extremity, from whence it grows wider towards the oefophagus, at whofe infertion its light or fecfion is the largefi of all ; from thence it di- minifhes by degrees, till, bending in a contrary direction to itfelf, it ends in the pylorus. Its bulk depends on the quantity of food, by which the cavity of the flomach is augmented ; and, on the contrary, it is di- minifhed by famine. Its fituation in general is tranf- verfe ; yet fo that the oefophagus enters its pofterior fide, and the pylorus goes out from it forward to the right fide. The middle of the human body, or enfi- form cartilage, thus covers or anfwers nearly to the cen- ter of the flomach ; but alfo to the right fide, and lafl- }y to the pylorus ; to the latter anfwers the umbilical fiffure. Since its figure is round but incurvated, its lower convexity will form a larger pendulous arch when empty ; but when full, it fhow’s itfelf prominent before, and in contadl with the peritonseum. On the other hand, the leffer arch, intercepted betwixt the two orifices, w'ill in this ftate of the flomach lie per- fe£lly backward towards the fpine, fo as to include the fmall lobe of the liver. Thus the infertion of the cefo- phagus into the full flomach will be in an obtufe angle, in Chap. XX. STOMACH. 529 in a manner parallel with the horizon ; but in the emp- ty ftomach it will be almoft perpendicular : and at the lame time, the right extremity of the ftomach forming the pylorus, which in an empty ftate lies bent upward, will in the full ftomach be bent more backward, fo as to defcend in perfons lying on their back. In a living man, that fituation of the ftomach which we have attributed to the full one is nearefl; the truth. 623. In the neighbourhood of the ftomach lie the vifcera : and particularly to its large Imperforated extre- mity is connefted the fpleen, by a confiderable portion of the omentum ; the lefler arch or curvature of the fto- mach receiving the little lobe of Spigelius, as likewife the left lobe of the liver, largely interpofmg betwixt the ftomach and the diaphragm ; which lobe compreiTes the forepart of the ftomach ; below the margin of which, a portion of the ftomach lies immediately contiguous to the diaphragm itfdf ; yet fo as, by a moderate exten- fion, to lie hid within the bounds of the falfe ribs. Un- der and behind the ftomach, lies the pancreas, extended for a confiderable length in an empty fpace, upon the tranfverfe portion of the colon. Again, from the lefler curvature arifes the little omentum, to which is conti- nued the ftronger membrane that connedls the cefopha- gus with the diaphragm : nor is the large omentum connefted to the whole length of the ftomach ; but, leaving a deficiency to the right fide near the pylorus, it is continued on beyond the left extremity, into a liga- ment which connedts the ftomach and fpleen together. The ligaments, in thefe parts, are produdlions of the peritoneum ; which, receding from the diaphragm, fpreads itfelf over the ftomach, fo as to form its outer- moft coat. The pylorus lies between its mouths, on the forepart, more to the right fide, and a little lower down. 624. The fabric of the ftomach anfwers in general to that of the oefophagus : of which, indeed, it is aa expan- fion ; and, in fome animals, has in all its parts the fame appearance. The outermoft coat is from the peritonae- um. 330 S T O M A C II. Chap. XX. um, of confiderable ftrength, fo as to limit the reil, and aftbrd a fupport to the fubjacent mufcular fibres : this is expanded into the little and great omentum, and in that place the ftomach is without its outermod coat. Then follows the cellular coat, more abundant in the origin of the little omentum, where it contains little conglo- bate lymphatic glandules, which alfo holds true of the cellular fubftance in the great omentum but it is thin- ner and much lefs confiderable. betwixt the coats of the ftomach itfelf, whence the outer and mufcular tunic clofely cohere together: in this fubftance the larger branches of the veffels are diftributed. 625. Next in order appears the mufcular coat, neither eafy to defcribe or prepare. Here, indeed, we fee the longitudinal fibres of the oefophagus, coming to the ftomach, are detached one from another, along all the fides of the ftomach. Some of them, of more confi- derable ftrength, run on to the pylorus, along the lelfer curvature ; which, by degrees declining from their lon- gitudinal courfe, following the length of the ftomach, defcend into a plain of each fide, and are in part ftretched out through the pylorus into the duodenum itfelf, v/hcre they gradually difappear. Other fibres defcend to the blind fack of the ftomach, featcd on the left fide. And, finally, through every fcdion of the ftomach, from its blind or left extremity, to the the pylorus, are fpread concentric circular fibres, which, by degrees in- creafing in their thicknefs or number, are continued on with the reft of the circular fibres belonging to the fto- mach : this laft makes the moft confiderable order of the mufcular fibres. Laftly, the fphinefter of the cardia and oefophagus is compofed internally of fibres, arifing from the left fide of the oefophagus, and running to the right, pafs on each fide the gula, which they thus clofely embrace, and then degenerate longitudinally till they are loft under the circular or fecond ftratum near the pylorus. But the ligaments of the pylorus fo called, are two conftridfions, betwixt the two incurvations into which the pylorus is bent, formed by the forefaid lon- gitudinal Chap. XX. STOMACH. 331 gitudinal fibres, which run along from the ftomach to the pylorus, and are very clofely joined to the internal coat in their way. 626 . Immediately under the mufcular fibres, follows another cellular flratum, larger than the outermoft, fofter, more eafily inflatable, and confiding of larger cells or veficles than what we ufually obferve in the in- teftines. Within this cellular fubftance are fpread the veffels which, eoming from the larger trunks, perforate the mufcular coat, and are divided into an angular net- work. Under this lies the nervous coatj which is thick, white, and firm, and properly makes up the true nature or fubftance of the ftomach itfelf, after the manner of other nervous parts : and this is again lined internally with a third cellular ftratum, evidently enough to be perceived, whofe vafcular net-work is much more mi- nute than that of the former, from whence it is derived. Immediately within this lies the villous coat, that lines the cavity of the ftomach itfelf, continuous with the ex- ternal cuticle, like which it is renewable ; but of a foft mucous texture, and extended into a very fhort pile, and folded into large plates, \yhich form a ftar un- der the cefophagus ; but in the middle of the ftomach, thefe folds are almoft parallel with the ftomach itfelf. But, at the extremity of the pylorus, there is a more confiderable fold, commonly called valvula pylori, which is formed by a production both of the tranfverfe mufcular fibres, and of the thicker nervous coat, ex- tended together in the fhape of an unequal loofe ring, produced towards the duodenum ; this forms a flippery flefhy protuberance, which furrounds the duodenum for a confiderable length. The large wrinkles of the vil- lous membrane are afterwards fubdivided more minute- ly into others of a quadrangular or net-like figure ; but very ftiallow, and eafily difappearing, being much more obfcure than thofe in the biliary duCts. Within this , villous coat of the ftomach throughout, but more efpe- cially towards the pylorus, I have truly obferved fome S f pores. S'P S’T'O MACH. Cnkp. Xf 5 t pore’s, not always to be perceived, which terminate in fimple follicles, feated in the next cellular ftratum. 627. The vejfels of the ftomach are both numerous and derived from many trunks or various quarters, that the courfe of the blood through them might not be in- tercepted by any kind of prefl'ure, as it might eafily have been if the veffels of the ftomach had come from' a fingle trunk. The common mother ol all thefe gaftric arteries is the coeliac ; frbrn the threefold divifion of . which, or above the faid divifion, arifes tlie upper co- ronary, which is the firft^^d largeft artery that paflcs in a fingle branch round the ed^e of the oefophagus in- to the ftdmach ; to which, firft, and -afterwards to the diaphragm and to the liver, it fends off fome ramifica- tions ; and then running on the leffer arch or curve of the ftomach, it inofculates by more than one branch with the leffer coronary of the right fide, arifing from the right branch of the coeliac at the vena portarura, and is diftributed along the Idler curve of the ftomach. But the fame right branch of the coeliac, arifing behind the duodenum, along which it defcends, gives off a very confiderable artery that runs contrary to the great arch or curve of the ftomach, the right ga flro-epiploica, which being fufpended in the omentum, it fpreads itfelf both upon each fide of the ftomach, and upon the greater part of the omentum itfelf, being at laft inferred into the left gajlro-epiploica. Namely, the left trunk of the coe- liac, paffmg along in the direftion of the pancreas and finuofity of the fpleen, there fends off many branches to the ftomach : of which the firft are commonly namelefs ; and among the following, one branch, more confider- able than the reft, is called the left gajlre-eplploica^ which fends off a confiderable twig to the omentum, with fome others that are fmaller ; from whence, de- feending round the ftomach towards the right fide, it inofculates with the right artery, which is its compa- nion. Other fmaller ones, coming from thofe of the fpleen, are fpread upon the greater curve of the fto- mach, even as far as the diaphragm, under the deno- mination Chap. XX. STOMACH. 333 iBin^tlon of the vafa hrevia. Frequently, alfo, one or arteries come from the fplenic one, to the pofterior llJlate of the ftomach under the cefophagus, in another line from the gaftro-epiploics. The other fmaller arte- ries 'are the upper ones of the pylorus from the hepa- lics, and the lower ones from the gaftro-epiploics : but thofc of the lower part of the cefophagus, are from the phrenic arteries. 628. Thofe arteries are diftributed in fuch a manner, that firft they fend off fliort twigs to the external and to the mufcular membranes, of the ftomach; their trunks are fet in order in the firft cellular ftratum ; from whence, diminifliing, a little in fize, they penetrate through the mufcular coat ; and between that and the nervous mem- brane, they compofe a larger and true net-work ; in which all the fmall arteries, coming from a great variety of trunks, join one with another, by an infinity of ino- fculations. From this plexus, again, other Ihort, but numerous and very fmall ramifications, pafs through the nervous coat to the third or inner cellular ftratum, and are loft in the villous lining of the ftomach. 629. The veins have their branches diftributed in company with the correfponding arteries. The greater coronary from the left fide of the ftomach, generally goes t(^ the trunk of the porta, together with the brevia and left gaftro-epiploic ; while the right vein of the laft denomination joins with the middle vena colica, and, together w'ith a branch from the mefentery, pours its contents into the vena portarum. Finally, the right coronary vein belongs to the trunk of the vena porta- rum itfelf. All thefe veins are without valves ; and, like the arteries, there are upper coronary veins, with others of the cefophagus from the thorax, all commu- nicating together by inofculations, in fuch a manner, that there is a free paflage for the blood thence into the vena azygos, with which they inofculate. A 30. The nerves of the ftomach are both large and numerous, produced from the eighth pair, forming two complications about the cefophagus, of which the ante- S f 2 rior 334 STOMACH. Chap. XX. rior and lefs plexus defcends through the upper or outer fide of the ftomach to its greater curve ; and the pofte- rior plexus, which is larger, is diftributed through the lefler arch of the ftomach ; from whence it pafles, to- gether with the arteries, to the liver, pancreas, and dia- phragm itfelf. Thefe nerves may be every where tra- ced into the fecond cellular ftratum. The remainder, but efpecially the papillae, are more obfcure. From their number, the ftomach is extremely fenfible, info- much, that things which make no impreflion upon the tongue, will naufeate and pervert this organ, which is capable of much feverer pain than the inteftines ; as we know from infallible experience in difeafes : even the fkin itfelf, when naked by a blifter, is lefs fenfible than the ftomach. By making a ligature upon the nerves of the eighth pair, both the action of the fto- mach and the digeftion of the food ceafe. 631. Lymphatic vejfels I have obferved, fometimes very confiderable, about the lefler curve of the ftomach, arifing from the glandules of that part, and inferted by a very large trunk into the thoracic du£l. Others, no doubt, arife from fmall glandules of the fame kind in the greater curve ; and fome famous anatomifts have obferved lymphatic glands over the whole ftomach. Other lacteal veffels, I have neither feen, nor am ready to admit; fuch as thofe lately deferibed, which are faid to pafs from the ftomach through the omentum to the liver, filled with a true chyle. 632. All parts of the human ftomach are perforated by inorganic pores, through which water inje(fted both exhales through the ftomach when fliut, and, on the contrary, penetrates the cavity of the ftomach when put under water. But we cannot for this reafon conclude, that in a living perfon this paflTage lies open for moi- fture. 633. Within the human ftomach, we firft meet with a great quantity of mucus, fpiead upon its villous lining, from the pores before deferibed (626.); which mucus is not unfrequently tinged, by fome of the bile return- DIGESTION. Chap. XX. 33 S ing into the ftomach. Befides this, in an empty mach after fading, upon bending the body, a great quantity of a limpid hu 7 nour will arife into the mouth, altogether of the fame nature with the faliva, but more mucous ; which liquor is very rarely to be found pure or unmixed in the domach. It is very far from poffeffing any acid acrimony, when it can be had pure from the food. Left to itfelf, it changes, both in man and brutes, rather to a lixivial or alkaline na- ture, when it is feparated from the acid illuvies of the aliments, more efpecially in an hungry animal. This liquor didils from the arteries of the domach, through its villous coat, after the manner we fee by anatomical inje into a bag. At the place where the colon fuRains it, and alfo from part of the inteftinum reftum, the mefo- colon, which is cominudns with the outer membrane of the inteftine, forms itfelf-into fmall flender bags, for the moft part double, thicltv.,dhd bifid, free at their extre- mities, and capable of admitting air driven in between the plates of the mefocolon. 661. From thence forward the inefentery follows, as a broad plaited production of the peritonaeum, conti- nuous with the tranfverfe mefocolon,' and extended on the right fide forward, and downward from the emer- ging duodenum ; and then from the left or long mefo- colon, even as low as the pelvis. Thus the mefentery is formed by the plates of the peritonmum, which lie upon the aorta, extended forward and together, under the right portion of the tranfverfe mefocolon ; and, de- feending obliquely under the pancreas, it contains the long feries of the fmall inteftines, within its capacity, difpofed in numberlefs folds. 662. The whole feat and extent of the mefentery and mefocolon hold a portion of fat, collecbed commonly more in proportion as they go longer within the capaci- ty that is neceifarily formed by the reduplication of their membranes and veffels interfperfed and furround- ing the fat, which the arteries feparatc, and the veins, as already mentioned, reforb; there are alfo very nu- merous glands, which are moftly confpicuous in a young perfon. 663. The ftruclure of the omentum anfw'ers very nearly to that of the mefentery. But there are many membranes that come under this general denomination, of the fame ftruClure and utility, all compofed of very tender and fine membranes, eafily lacerated, betwixt which the blood-veffels are difpofed reticularly, with fat depofited in ftreaks near the fides, and in the fame di- reftions with the reticulated veffels themfelves. This membrane is always double ; the two plates of which are joined together clofely by a very tender cellular fub- ftance, within which the veffels are diffributed, and the fat Chap. XXL G.M E N T U M. 349 fat collected. And, firft, where the top of the right kidney .arid' the infulc^ated lobe of the liver, together with the Subjacent blood-veffels, meet with the duode- iiurn intb'aifangie, there the external membrane of the coloti,' which comes from the peritonaeum, joining with the other membrane of the duodenum, v/hich is alfo from the adjacent peritonaeum, they go together overthe left kidney backward, and enter into the tranfverfe fif- fure of the liver, for a confiderable length ; from which the external membrane is continued over the gall- bladder which it contains, confining the vafcular fabric of the liver, very flippery, and tinged of a yellow co- lour. Behind this membranous produftion, betwixt the adjacent duodenum, right lobe of the liver, hepatic vefiels, vena portarum, and biliary duels and artery, lies a fmall natural opening, by which inflated air is largely received into all that cavity of the omentum which we (hall prefently deferibe as a bag ; and, lafily, into the bags of the rell of the omentum. 664. Erom thence, in a courfe continuous with this membrane (663.) from the pylorus and the lefs curve of the ftomach, the outer membrane of the liver joins jn fuch a manner with that of the ilomach, that the thin membrane of the liver is continued out of the foffa -of the venal duft, before the little lobule, into the fto- mach itfelf, ftretched both before the lobule and before the pancreas. This is called the little omentum hepa- tico-gajlricum ; which, inflated, refcmbles a cone; and, hardening by degrees when it is without fat, changes into a true ligament, by which the ■cefophagus and liver are conjoined together (623.) 66 jjg But the great gaJlrocoUc-omentum is of a much large^xtent. It begins at the firft joining of the right gaftro-epiploic artery to the ftomach, where it is conti- nued from the upper plate of the tranfverfe mefocolon (659.) ; and from thence it proceeds forward along the great arch or curve of the (lomach to the fpleen, and in part is continued alfo from the right convex end of •the ftomach towards the fpleen, even till it degenerates U u 2 . into 350 OMENTUM. Chap. XXI. into a ligament that ties the upper and back part of the fpleen to the ftomach. This is the anterior leaf of the omentum. 66S. This anterior leaf or lamina of the omentum floats loofely downward before the inteflines, fometimes to the navel, fometimes to the pelvis, behind the mufcles of the abdomen ; and, making a thin edge, is folded back again in a diredtion contrary to itfelf, and afcends fo as to leave an intermediate vacuity, by which the fore leaf is remo- ved from the pofterior ; and being at length continued for a confiderable extent into the outer membrane of the tranfverfe colon, and laflly continued in the finus of the fpleen by which the large blood-veffels are received, it ends in the oefophagus, under the diaphragm. Behind the ftomach, and before the pancreas, the cavity of this is continued into that of the leffer omentum. 667. To this is continued the omentum colicum, which arifes on the right fide only from the colon and its external membrane, immediately after the origin of the omentum gaflrocoUcum from the mefocolon, with whofe cavity it is continuous, but produced by the co- lon and its membrane, which departs doubled from the intefline, forms a produdfion ending conically, and is ter- minated by a longer or fhorter extent above the intef- tinum cascum. 668. The ufes of the omentum are many. Its com- mon ufe is, together wdth that of the mefentery, to form an ample fpace, of a loofe texture, into which the fat may be poured from the arteries, at the time of fleep and inadfivity of body, to be afterwards dilTolved by motion, and returned again into the blood by the infor- bent veins, fo as to make a conflituent principle of the bile. Accordingly, you will feel the fat of the omen- tum to be very tenacious or vifcid betwixt the fingers, although of a thin confidence, and in its w'hole body more pellucid than paper. For that the fat of this part returns again into the veins, appears from the ditferent bulk and w'eight of fat obfervable in the various omen- ta of different perfons, according as they lead either an t Chap. XXL OMENTUM, 351 idle, laborious, or morbid courfe of life; to which add, its appearances in various brute animals, with the relation it bears to all the reft of the fat of the whole body (20.): from experiments in frogs, where this re-abforption of the fat may be made evident to the eye : and, laftly, from the apparently inflammable na- ture of the bile itfelf. Hither we muft alfo refer the diforders and crudities of digeftion, together with the coldnefs of the ftomach, obferved to follow after cut- ting out the omentum. 66 9. For all the blood which returns from the omentum and mefoeolon, goes into the trunk of the vena portarum, and by that into the liver itfelf. The omentum is furniflied with blood by the gaftrocolic and by each of the gaftro- epiploic arteries, defeending in many fmall branches, and fubdivided in a reticular manner : of thefe, the ar- teries on each fide run to the greateft length ; but the inner or pofterior leaf of the omentum has fmall arte- ries, which go out from thofe of the colon. Branches alfo come to it from the fplenic, duodenal, and adipofe arteries. The omentum colicum has alfo its arteries from the colon, in the fame manner as the fmaller ap- pendices (660.) The arteries of the leflTer omentum come from the hepatics, alfo from the right and left co- ronaries of the ftomach. 670. The nerves of the omentum are very fmall, as being a fat and indolent body ; yet it receives fome little branches from the nerves of the eighth pair, both in the greater and in the lefler curve of the fto- mach. 671. The arteries of the mefentery are, in general, the fame with thofe that go to the inteftines ; the fmal- ler branches of which go to the fmall glandules and cel- lular fat, included within the mefentery. But, to the mefoeolon, fmall arteries are diftributed on all fides from thofe of the various parts conneded to it ; as the intercoftals, fpermatics, lumbals of the renal capfules, and tranfverfely from the fplenic artery, with the pan- creatic branch of the duodenum : but, in the left me- focolon, 352 OMENTUM. Chap. XXI. focolon, there are alfo fmall arteries detached from the aorta itfelf to the glandulae lumbales. 672. '^The veins of the omentum, in general, accom- pany the arteries, and unite into fimilar trunks : thofe of the gaftrocolic omentum from the left fide open into the fplenic, as do thofe of the hepaticogaftric, which likewife fends its blood to the trunk of the vena porta- rum : thofe from the larger part of the right gaftrocolic omentum go to the mefenteric trunk ; as do thofe of the omentum colicum, with thofe of the appendices epi- ploides. All the veins of the mefentery meet together in one, which is truly’ the trunk of the vena portarum : in forming which, 'tney are firft collefted into two large arms; of which one receives the gaftro-epiplgica, with the middle colic and iliocolic veins, and all thofe of the fmall inteftines as far as the duodenpm ; the other arm, which goes tranfverfely acrofs the former^* which arifes above it, is embraced by the duodenum, "and re- turns the blood of the left colic veins, with thofe of the rectum, except the lowermoft, which belong partly to thofe of the bladder, and partly to the hypogaftric branches of the pelvis. The vein which is commonly called ha 7 norrhoidalis intertia^ is fometimes inferred ra- ther into the fplenic than into the mefenteric vein. If it be demanded. Whether the omentum has any lym- phatic veflels ? we anfwer in the affirmative : fince there are conglobate or lymphatic glandules, both in the little omentum and in the galtrocolicum ; alfo the ancient anatomifts have obferved pellucid vefiels in the omen- tum ; and, lately, a modern has deferibed them for lac- teals of the ftomach. 673. Other ufes of the omentum are, to interpofc betwixt the inteftines and peritonaeum, which, by in- flammation, are very apt to grow together ; to keep the former in a ftate of free motion, as well among themfelves as againft the peritonaeum, with but little attrition ; and to anoint the mufcular and membranous fibres with a very foft oil. For thefe reafons, even in mfefts, there is a great deal of fat placed round the in- teftines. Chap. XXL OMENTUM. 355 teftines. In the large inteftinf^s, there are a great ma- ny appendices, which likewife are produced from the large branches, and cannot altogether cover the omen- tum. But th6 fame fets the vcffels in order; condudsand gives them ftrength ; and exhales a foft vapour, which, mixed with the exhaling abdominal water, anoints and lubricates dll the vifcera. 674. The mefentery ferves to fufpend and dtfplay the inteftines in fuch a manner, that they may move freely, and with a degree of firmnefs ; it ferves as a bed to fuftain, and fafely conduft the numerous velfels, nerves, and glandules ; of which laft we lliall fpeak hereafter : it alfo gives an external coat to the inteftines, and forms moft of the omenta. 675. But, befides, the blood, returning through the mefenteric and mefocolic veins, brings with it another principal. conftituent part of the bile; namely, a fub- alkaline watery humour, which is abforbed by the veins from all theimall inteftines, as will be demonftrated in its proper ’^lace. Befides this, it gives to the liver a more putrid water from the large inteftines, which is fetid, and nearly approaches to a volatile alkaline nature, abforbed from the fasces, that now begin to fmell ftrong ; the exiftence of which is eafily proved, both from our own experiments, and the drying of the fasces when too long retained. This water is, therefore, a fluid in it- felf, and rendered more fo by an incipient putrefadion ; and, confequently, it ferves to reduce the tenacity of the oil belonging to the omentum and mefentery, fo as to keep it from congealing. But more efpecially in the bile, it conftitutes the acrid alkaline quality, with which this humour abounds ; and from thence comes the great tenuity and faponaceous force of the bile, fo ufeful to dyers and painters. CHAP. ^54 SPLEEN. Chap, XXII. CHAP. XXII. Of the S p L E E i-r. 676. ^T^HE fpleen itfelf is one of thofe intermediate A vifcera, which fend their blood to the liver. It is a blueifli, pulpy, fomewhat oval vifcus, fomething like a mafs of congealed blood in its confiflence, having frequently a notch or incifure in its oval circumference; whence it is convex towards the ribs, concave inward- ly, and circumfcribed with two margins or edges, of which the inferior and anterior is the fharpefl;. It is connected to the ftomach by the little omentum; and above that, by the upper ligament, fupported by the fubjacent colon, and by another ligament (638.) be- hind the renal capfule ; to which, and to the kidneys, it adheres by the peritonaeum. It alfo receives the perito- aeum from the diaphragm, under the denomination of a ligament, in the back-part of its hollow finus, behind its velfels. The fituation of it varies with that of the ftomach itfelf, which it follows. When that is empty, the fpleen is raifed perpendicularly, fo as to place its extremities right up and down : but when the ftomach is full, the middle curve or arch of it arifes upward and fore-ward (622.); and at the fame time obliges the fpleen to change its fituation, fo as to lie almoft tranfverfely with its lower end forward, and its upper end backward. Thus, being of a very foft and loofe texture, it grows larger by diftention w'hen the ftomach is empty, and becomes lefs again when its blood is prefled out by the diftention of the full ftomach againlt the ribs. From hence the fpleen is found large in thofe who die of lin- gering difeafes ; but in thofe who die fuddenly, and in full health of body, it is fmall. Another motion of the fpleen is, that of defeending with the diaphragm in in- fpiration, and afeending again in exfpiration ; and be- fides this, the fpleen frequently varies in its fituation with CHAr. xxn. SPLEEN. 355 with that of the colon. Frequently there is a fecond or lefs fpleen placed upon the former. 677. The blood-veffels of the fpleen are large, In proportion to its weight. The arterial trunk comes from the cceliac ; the upper branch of which, proceed- ing in a ferpentine courfe above and behind the pancre- as, to which it gives branches, as well as to the mefo- colon, ftomach, and omentum, is at length incurvated in the direftion of the fulcus or notch of the fpleen, which it, after a manner, perforates by feveral diftinct branches, fuflained at the right extremity by the omen- tum gaftrocolicum. The thicknefs of this artery is greater than that of the aorta. The fplenic vein, which accompanies the artery, is confiderably fofter than any other veins of the body; it forms the principal left branch of the vena portarum. Befides thefe, the fpleen receives fmall arteries from the great coronary, de- fcending behind the pancreas, and fometimes from the internal hasmorrhoidal. The vafa brevia of the fpleen and ftomach we have mentioned elfewhere ; and its liga- ments and membranes receive fmall arterial twigs from the lumbar arteries, phrenics, intercoftals, and thofe of the renal capfules. In like manner alfo the veins in the fpleen, and thofe which join it to the ftomach, commu- nicate with the phrenics, and with the veins of the re- nal capfules. 678. The lymphatic vejfels of the fpleen are defcribed to arife in the duplicature of the fplenic coat or mem- brane (of which there is none at all), and from thence to proceed on to the receptacles of the chyle, very evi- dent in a calf ; in mankind they are rendered conipicu- ous by blowing air under the membrane, by inacera-* tion, or water injefted into the arteries. 679. The nerves of the fpleen are very fmall; frorn whence it is capable of but little pain, and is very rarely inflamed* They arife from a particular plexus, com- pofed out of the pofterior branches of the eighth pair at the ftomach (630.), and of certain branches from the latge gangliform plexus, which produces the fplenic X X trunk I ^ 5 ^ S"-P 1 E E N. ChXp. xnr. trunk of the interccftatnerve, from whence the branches furround the artery- into the fpleen. 680. The fabric pf’.the fpleen appears to be much niore fimple than hast)©en commonly believed. For it IS compofed, both m us and in calves, altogether of ar- teries and of veins; the-former of which, after fpend- ing themfelves in a great number of fmall branches, are at length thickly fubdivided into very foft brufli-like bunches, very difficult to fill with injeci’poh, terminating in circles ; by w'hich there is a ready pafpg^.fqr liquors into the correfponding veins. Thefe circles, wdth their parallel branches, form a fort of bunches like a pencil bruffi, but of a ffiorter rounder kind ; whence many have miltaken them for glands.: ' Nor does, the injec- tion, rightly managed, ever efcape from the velfels into the intervals ; nor were any hollow glandules ever difcovered by certain obfervation. Every little arterial trunk, with the fmaller twigs that proceed from it, are each of them furrounded by a very fine cellular fubfiance or web- work, in the fame manner with the fmall velTels of all the other vifcera, but here rather fofter. The whole body of the fpleen is outwardly furrounded by a fingle membrane, which is not very tough, continued from the peritonaeum, and joined to the flelhy part of the Ipleen by a pretty thick cellular texture. 681. Hence we obferve, that the fpleen contains more blood, in proportion, than any of the other vifce- ra ; fince it has no mufcles, fat, air-veffels, or excretory duffs, interpofed betwixt its blood-vefiels. We learn alfo from obfervation, that the blood of this part hardly ever congeals, from the abundance of its volatile or bi- lious falts : but it looks of a dark-brown colour, and may be eafily diluted ; whence one may compare it almofl to the blood of a foetus. 682. The want of an excretory duff to the fpleen, has occafioned the ufe of it to be doubtful, and contro- verted throughout all ages of anatomy. To us the fa- bric itfelf feems to lead to the following ufes ; although, perhaps, they do not comprehend all the ufes of the fpleeu> ■Chap. XXII. SPLEEN. 357 fpleen. A great quantity of blood is imported to the fpleen (677,), and with a flower motion, from the fer- pentinis eourfe and hardnefs of the artery : but, at the time whqn the flomach is empty, this blood comes, and is received in a greater quantity by the fpleen, not now fo much compreflTed, therein to flagnate, as it would, feem plainly from the great proportion of branches to the trunks in this part ; to which add, the difficult courfe or flow circulation which the blood meets with in pafling from the fpleen through the liver.: from hence the frequent fcirrhofities of the fpleen ; and from hence the immenfe quantity of blood with which the fpleen is in every point diftended, the like of which we do not fee in any other part. Here, then, the almofl ftagnant blood, fomented with heat, attenuated, and in a manner diflTolved by the putrid feces of the adjacent colon., enters thus upon the firfl fteps of a begun putre- faction, as we learn by experiments, both from its co- lour and confiflence. But the greater fluidity of the blood herein, proceeds not only from this diflfolution, but becaufe all its watery juices that enter by the artery return alfo again by the vein j for there are no fecreto- ry duds in the fpleen. 683. Moreover, when the flomach is full -of food or flatus, the fpleen is thereby compreflTed into a narrower compafs, againfl the ribs and fupcrincumbent dia- phragm, by which means the blood, that before was fcarce able to creep along through the fplenic veins, be- ing now preflTed out more plentifully, returns with a greater celerity towards the liver ; till mixing with the fluggifh blood in the trunk of the porta, replenifhed with the fat or oil of the omentum and mefentery (669.), it dilutes or thins the fame, and renders it lefs apt to flagnate or congeal ; and, at the fame time, it conduces to form a larger fecretion of bile at a time when it is mofl wanted, viz. to flow plentifully to the food now ■under digeflion. The fpleen, therefore, feems to pre- .pare the blood, that it may fupply a fort of watery juice to the bile 5 but fuch as is probably of a fubalkaline na- X X 2 ture. 35^ P A N C R E A S. Chap. XXIII. ture, and rendered fomewhat fharp by the remora of the blood. 684. Whether is the fpleen of a cellular fabric? Is the blood poured out into thofe cells fo as to ftagnate ? or is it diluted with fome juice fecreted by peculiar glands? We fee nothing of this is demonflrable by anatomy ; nor does the liquor or wax injected ever cx- travafate into the cellular fubftance, unlefs urged with much greater violence than nature ever ufes or intend- ed. As to the old queftion, Whether the fpleen brews up an acid to whet or (harpen the ftomach ; that opi- nion has been long difearded, as repugnant to the na- ture of all the animal juices. If it be alked whether the fpleen be not an ufelefs mafs, as it might feem to be, from the little damage an animal fuftains after it has been cut out? we anfwer, That a robuft animal, fuffer- ing but little injury from the lofs of a part, does not prove it to be ufelefs ; and yet there are examples, after fuch an experiment has been made, that the liver be- comes fwelled and difordered, makes a lefs quantity of bile, and of a darker brown colour ; while the animal is perpetually troubled with flatulencies, gripes, or indi- geftion: all which are to be aferibed to the vitiated na- ture of the bile, an obftrudtion of the liver, and an im- perfedf or weak digeflion ; at the fame time they are confirmed by repeated experiments. CHAP. XXIII. Of the Pancreas. ^85. H E pancreatic juice^ which is watery, infi- A pid, thin, neither acid nor alkaline, is poured into the fame place into which the bile difeharges it- 'felf. 686. The pancreas is then a very long glandule, the largefl of the falival kind, extended over the inferior la- mina of the tranfverfe mefocolon ; which, beyond the pancreas. Chap. XXIII. PANCREAS. 359 pancreas, behind its fuperior lamina, behind the fto- mach, before the fpleen, under and behind the liver, meets with the inferior lamina : it lies before the left capfule and the aorta ; is plain, and of a triangular fhape, with a light ftroke on the upper part, and covered with the peritonaeum, upon which the pofterior flat fide of the empty ftomach is fupported ; for that fide of the ftomach is both lower as well as pofterior. The pan- creas begins fmall from the fpleen itfelf ; and extending almoft tranfverfely towards the right fide, it emerges forwards to the peritonaeum, acrofs the vertebrae, to the right fide of which it grows confiderably broad, being received betwixt the fuperior and inferior plate of the tranfverfe mefocolon (659.); and is, finally, fo con- nefted by its round head to the duodenum, that this inteftine ferves it for a mefentery. The ftrudfure of it is,. like that of the falival glands, made up by a -great number of fmall kernels of a firm texture, connefted to each other by a good deal of cellular fubftance. The pancreatic blood-vejfels are rather numerous than large, derived chiefly from the fplenic branches : but on the right fide it is fupplied by the firft artery of the duode- num, and from that other which is lower down, and is in common both to the duodenum and pancreas ; both, of which arife from the hepatic artery, and of which tfie former inofculates with the latter, and both with the mefenteric artery, which fupplies conliderable twigs to this gland ; but the fmaller ramifications come from the phrenic and capfular arteries. The nerves of this gland are not of any confidcrable fize ; whence it is but little fenfible : they are derived from the pofterior gaftric and the hepatic plexus, from that of the fpleen, &c. 687. The excretory duil of this gland runs almofi: through its middle, white and tender, arifing every where from a great number of roots ; by which, being gradually increafed, it emerges before the vena porta- rum and mefenteric artery, and receives a large branch from the lateral pancreatic portion ; from whence it ad- vances to the fame part of the duodenum into which the g<5o PANCREAS. Chap. XXIIL the biliary dud opens ; where, changing its courfc downward, it enters through the finus that lies betwixt the coats of the inteftine, internally fmooth ; and here, receiving the dudus choledochus, it opens together with that into a certain fold of the fame duodenum, defcend- ing towards its lowed; part. But not unfrequently it opens diflind, both in its dud and orifice, from that of the biliary dud; and fometimes it is infcrted by two duds, of which the lower one only is diftind and lefs ; but in man, and mod other animals, it always opens near the dud of the bile. In its mouth there is no bile. 688. The quantity of juice fecreted by this gland is uncertain : but it muft be very confiderable, if we com- pare the bulk or weight of it with that of the falival glands ; than which it is three times larger, and feated in a warmer place. It is expelled by the force of the circulating blood, with an alternate preffure from the incumbent and furrounding vifcera ; as the liver, fto- mach, fpleen, mefenteric and fplenic arteries, with the aorta. The great ufefulnefs of this gland may appear from its being found not only in man, but almofi; in all animals : nor is its ufe the lefs from that experiment which fhows a great part of it may be cut out from a robuft animal without occafioning death ; becaufe, in the experiment, a part of the pancreas mult be left with the duodenum. Its effervefcence with the bile arifes from the effed of a ligature, and air mixed with the inteftinal humour. 688. The pancreatic juice feems principally of ufe to dilute the vifcid cyftic juice, to mitigate its acrimony, and mix it with the food. Hence it is poured into a place remote from the cyftic dud as often as there is no cyftis. Like the reft of the inteftinal humours, this juice dilutes the mafs of aliments, refolves them, and does every other office of the faliva. CHAP, Chap. XXIV. LIVE R, 3^1 CHAP. XXIV. Of the Liver, Gall-Bladder, and Bile. 689. n|^HE UveKy being the largeft of all the vifcera, jL fills up a very large part of the abdomen in its upper chamber, above the mefocolon ; and is yet ftill larger in proportion in the fetus. Above, behind, and to the right fide, it is covered by the fuperincumbent diaphragm, from u'hich it receives the peritoneum for a covering, under the denomination of ligaments, chiefly in three places : for on the convex part of the liver, from the paflage of the vena cava to the tranfverfe fur- row of the liver, the peritoneum defcends double, growing broader in the forepart, under the name of Ugamentum fufpenforium, which divides the greater right lobe from the lefler left lobe of the liver ; and then parting from its duplication, it expands into the proper coat of this vifcus (623.), which is white, Ample, and thin, like the external coat of the fiomach ; and under this is fpread the cellular fubftance, by which it is inti- mately conjoined with the flelh of the liver. To the lower margin of this, joins the umbilical vein ; which, in an adult, being dried up, leaves only a fmall cord, furrounded with much fat. In the extremity of the left lobe, and on the convex part, not unfrequently at its edge, a membrane goes to the liver from the diaphragm j which in children, and other young fubje£ts, is fre- quently to the left fide of the oefophagus, but in adults to the right fide ; yet always conjoined both to the gu- la and to the fpleen, whenever the liver or the left li- gament is very large. The right ligament ties the dia- phragm in its hinder part to the thickeft; part of the right lobe. Befides, but without any apparent length, the membrane of the right lobe of the liver is often conjoined by the cellular fubftance with the diaphragm ; more efpecially in old fubjefts, for in the fetus it is eafily 3<$2 LIVER. Chap. XXIV. eafily feparated ; and then it continues its courfe be- twixt the fufpenfory and left ligament, joined as before with the peritonaeum, fo as to refemble a ligament. But alfo from the right kidney, the peritoneum going off to the liver, makes a reduplication like a ligament, and conjoins together the lefs omentum with the con- tinued loofe productions of the inefocolon (663.) with the liver, fforaach, and duodenum ; and hkewife the fame inefocolon to the pancreas. Thus the liver is fufpended in the body, with a confiderable degree of firmnefs ; yet fo as to be allowed a confiderable liberty to move and be varioufly agitated, raifed, and depreffed, by the actions of the diaphragm. The fame ligaments form a common membrane, which covers the liver as well as other vlfcera. • 690. Moreover, the inner concave face of the right liver lies with its forepart before the colon; and in its back part correfponds to the right kidney and re- nal capfule, to w^hich it is conneded by the cellular fub- ffance. The middle finus lies near the duodenum, which touches the gall-bladder ; and alfo lies contigu- ous with that part that conduds the great blood-veffds. The left lobe extends largely over the ftomach ; and frequently, efpecially in younger fubjects, goes beyond the oefophagus into the left hypochondrium. The lo- bule, in the mean time, adapts itfelf to the leffer curve of the ftomach. But, moreover, the pancreas is co- vered by the liver, and the right renal capfule is tied to the part of the liver fartheft to the right fide by much cellular texture. 691. The figure of the liver is difficult to defcribe. It begins in the cavity of the right hypochondrium, by a very thick folid protuberance, convex towards the diaphragm, and hollow towards the colon and kidney ; having a protuberant line dividing the faces of thefe Imall hollows, w'hich is continued to the longer appendix of the lobule. After this, the liver grows flenderer and thinner, and is at laft terminated or exte- nuated into a tip, almoft triangular ; which, paffing into Chap. XXIV. LIVER. 3^3 the left hypochondrium, goes before the oefophagus, in young fubjeds, as far as the fpleen ; but in adults, it is often fliorter, and ends at the oefophagus. The edge, in which the convex part of the liver meets with the concave one, is wholly in the fore and lower part. The whole obtufe margin lies backward. The upper and back part of the liver is every where convex ; fuftains the diaphragm ; and in a large part, which is fomewhat flatter, towards the left fide, it is placed under the heart ; but the lower furface, being varioufly figured, refis itfelf upon the duodenum, colon, ftomach, pan- creas, and right renal capfule. For there are feveral little furrows which divide the furface into different re- gions, and which did not efcape the notice of the an- cients. 692. The principal of thefe furrows is extended tranfverfely, from the right fide to the left, and divides a third part of the liver, beginning flender in the right lobe, and growing broader towards the left. Before this tranfverfe fulcus, there is an excavation in the right lobe for the gall-bladder, and then the anonymous con- vex lobule ; after which comes the foflfa of the umbili- cal vein, extending tranfverfely backward, often cover- ed with a procefs or bridge that joins the anonymous to the left lobe ; but behind the great fulcus, firfl towards the right fide, there is a flender tranfverfe eminence growing broader to the right, and moderately hollow, by which the great blood-velfels are conducted into the liver : and this little valley was by the ancients deno- minated the porta or gates of the liver. This joins the lobule, which I lhall defcribe, with the right lobe. Then the pofterior lobule, fhaped like a nipple, obtufely co- nical, projects into the lefs curvature of the ftomach. The thick root of this and the former excavated emi- nence, begins from the convex part of the liver, at the diaphragm ; and from thence, on the right fide, is im- preflTed with an oblique furrow, inclined to the right fide, for the paflage of the trunk of the vena cava, de- fending from the heart to the lumbal vertebrte j and is Y y fre- 364 LIVER. Chap. XXIV. frequently furrounded by a great part of the flefh of the liver, like a bridge, or even fo as to complete the circle, and form a tube. The left end of the lobule is termi- nated by another foffa almoil llraight backwards, but inclined to the left ; which, taking its origin from the extremity of the tranfverfe one, terminates at the paf- fage of the vena cava through the diaphragm. In this fmus was lodged the ductus venofus in the fetus, of which there are fome remains to be perceived alfo in the adult. All that lies beyond this is the left lobe, which is Tingle, equally concave below, fo that it may lie upon the ftomach, and is extenuated to a thin edge. 693. This fo large vifcus is proportionably fupplied with veffels, and of various kinds. The artery, which is indeed confiderable, being the greater right portion of the csliac, emerges from the trunk forward, and to the right, going tranfverfely before the vena portarum ; and alter giving olf a fraall coronary with the pancreatic and duodenal artery, the lafl of which is pretty large, it goes on and enters the liver, commonly by two branches ; of which the left is betwixt the umbilical fof- fa, the venal duel, pofterior lobule, with the left and the anonymous lobe, alfo the furpenfory ligament ; and this branch inofculates with the phrenic and epigaftric arteries. The right enters the liver lower, covered by the biliary duels ; and having reached the right with the anonymous lobe, there fends off, in one fmall trunk, the cyftic artery, which foon after divides into two, and is fpread both under and upon the gall-bladder, cover- ed by the common coat of the liver, and fupplies not only the gall-bladder and biliary du£ls with its branches, but likewife fome part of the liver itfelf. From the left branch, or fometimes from the trunk of this, arifes a fuperficial artery to the biliary dulls, anonymous lobe, and glandules of the portae. Befides the cceliac artery, there is frequently a large right branch produced from the mefenterica major, creeping behind the pancreas ; and this ferves inftcad of the eighth branch of the he- patic Chap. XXIV. LIVER. 3^5 patic artery from the caeliac. But, llkewife, the greater coronary, which is the firft twig of the cseliac, always gives fome ramifications to the left lobe, and to the foffa of the ductus venofus ; which laft branch is often very confiderable. The leffer arteries are thofe fent to the liver from the phrenic, mammaries, renal and capfulary arteries. They communicate alfo with the epigaftrics. 694. In the fetus, the umbilical vein brings much blood to the liver, at which time the vein ftretching to the portae is but fmall. It fends forth branches while it flretches backwards through its foffa ; thefe branches are numerous, and very large; fo that one of them e- (|uals the vena portarum in bignefs, in that place where it is dilated into a tumour, which unites with the left branch of the vena portarum. But it fends one branch through the poflerior part of the horizontal fofla into the vena cava, or fome of its hepatic branches : this is called the dudus venofus. In an adult perfon, indeed, this duQ: is filled up; and the vena portarum, which now grows larger, fills the hepatic branches. 695. The vena portarum receives all the blood of the floinach (62 9.),oftheinteflines and mefentery (631.), of the fpleen (677.), omentum (669.), and, laftly, of the pancreas, at firft into two trunks, the tranfverfe fplenic and afeending mefenteric ; then into one, which is con- tinued with the mefenterics. This is large, compofed of ftrong membranes, firft a little bent behind the duo- denum, where it receives the veins from its right fide, together with the leffer coronary ; wdience going higher to the right fide, it again divides into two large trunks in the finus of the lobule of the liver (692.), and imme- diately after is again divided into two large trunks. Of thefe two, the right, being fliorter, larger, and bifur- cated, having received the cyftic vein, goes to its own lobe. The left runs on through the remaining part of the tranfverfe furrow of the liver ; and, after giving veins to the lobule, with the anonymous and left lobe, it is incurvated and enters the umbilical foffa ; from whence, about the middle, it immerges and ramifies y y 2 through 366 LIVER. Chap. XXIV. through the liver. There are fome inftances in which the venous branch of the pofterior lobule has been fent diftin£t from the vena portarum. 696. The vena portarum is on every fide furrounded with a good deal of cellular fubftance, derived to it from the mefentery and fpleen, denfe, fhort, and adding flrength to the membranes ; thofe with which it is fur- nifhed being harder than the aorta itfelf. Intermixed with this cellular fubllance, are alfo many of the fmal- ler veffels and hepatic nerves, which all come together under the denomination of a capfula, which is nothing more than the cellular fubftance, and never has truly a fingle flefhy fibre. By this the vena portarum is con- duced to the liver, and firmly fuftained ; infoinuch, that the branches, being cut, maintain the round lights of their feCions. But each branch of this veflcl is di- ' vided into many others, again divided and fubdivided, after the manner of arteries, till they at length produce the fmalleft capillaries. In this courfe, every branch of the vena portarum is accompanied with a focial branch of the hepatic artery, creeping upon the furface of the vein, and the contiguous hepatic duCs, ahnoft in the fame manner as the bronchial arteries ufually creep along the ramifications of the windpipe in the lungs; while, in the mean time, both the artery and the vein are conneCed to the branches of the biliary duCs by a thin cellular fubftance like a fpider’s w-eb. Some go out of the liver, being divided to the ligaments, and inofculating with the furrouncling veins. And the fum of the branches in the vena portarum is always greater than the trunk ; whence the lights of all the branches together greatly exceed that of the trunk (37.): from whence follows a great friction or refiftance (iBo and 162.), after the fame manner as we obferve in the ar- teries. 697. But, fince the blood is in this manner conveyed through the liver to the branches of the vena portarum, together w'ith the hepatic artery, it muft of courfe be conveyed back again by fome other veins: and, there- fore. Chap. XXIV. LIVER. 3^7 fore, the extreme branches of the vena portarum and hepatic artery inofculate ultimately into other veins, which are branches of the cava ; which arifmg from the whole circumference of the liver, run together towards the pofterior gibbous part of the liver into branches and trunks, which at laft go off into ten or more large vef- fel^. The leffer of thefe trunks, and greater number of them, pafs out through the pofterior lobule of the liver, and go to the cava through the fulcus, that lies on the right fide of the lobule, often completed into a circle by a fort of bridge or produdllon of the liver; from whence they afcend together through the diaphragm to- wards the left fide. Two or three trunks, much larger than the former, are inferted into the fame cava, clofe to the diaphragm, whofe veins they often take in by the way. The branches of the vena cava are, in the adult, generally fewer and lefs than thofe of the vena porta- rum ; which is an argument that the blood moves quicker, becaufe of the lefs fridlion (lyo.j, and of the very colleftion of the blood into a lefs light or capacity, by which it is always accelerated when there is a fuffi- cient comprefling force (i 70.) As to any valves at the openings of thefe branches into the cava, 1 know not of any which deferve to be regarded. The trunk of the vena cava, palling through a foramen of the diaphragm, obtufely quadrangular, furrounded and terminated by mere tendons (262.), is thereby rendered not eafily changeable: and having furmounted this opening of the diaphragm, it then immediately expands into the right auricle. The fmaller veins of the liver creeping about its furface, are fent forth from the phrenics, re- nals, and azygos ; or at leaft there is certainly a com- munication betwixt thefe and the hepatic veins coming from the portse. 698. That the blood comes from all parts (6p^.) by the vena portarum to the portae, is proved by a ligature, by which any vein betwixt thefe parts and the ligature fwells ; but the porta itfelf, above the ligature, grows flaccid and'^mpty. But that it afterwards goes through LIVER. Chap. XXIV. the liver to the cava, appears by anatomical injeclions, which Ihow open and free anaftomofes or communica- tions betwixt the vena portarum and the cava, together with the common nature of the veins going to the cava. Again, the difficult dihribution or paffiage through the vena portarum, like to that of an artery, together with its remotenefs from the heart, and the oily or fluggiffi nature of the blood itfelf, occafion it to ftagnate, accu- mulate, and form fcirrhous fwellings in no part oftener than the liver. But this danger is diminiffied by the motion of the adjacent mufcles, and by the refpiration ; as it is increafed by inactivity, with four and vifcid ali- ments. But, hitherto, we have been fpeaking of the adult liver, in which both the umbilical vein and the du£lus venofus are empty and clofed up, although they continue to cohere with the left branch of the vena por- tarum. 699. The nerves of the liver are rather numerous than large; hence, when wounded or inflamed, it is capable of no very great pain. They have a twofold origin. Molt of them arife from the large gangliform plexus, made by the fplenic branch of the intercoflal nerve, with the addition of a branch from the pofterior plexus of the eighth pair ; they accompany the hepatic artery, and, playing round its trunk, are diftributed with that and the portal branches throughout the liver. Another fafciculus of nerves ufually enters w'ith the du£lus venofus, and arifes from the poflcrior plexus of the eighth pair, but fometimes from the great plexus. 700. The lymphatic vejfels of the liver are nume- rous, being conltantly and eafily to be feen about the portae. They arife from the whole concave furface of the liver and gall-bladder, and run together into a plexus, furrounding the vena portarum, going after- wards to the fmall conglobate glandules, feated before and behind the faid vein ; from whence they meet to- gether in one large trunk, which is one of the roots of the thoracic duft. Upon the convex part of the liver are LIVER. Chap. XXIV. 3^9 are defcribed other lymphatics, whole infertion is not well known ; but it is hardly probable that they enter the cava, nor have I been able to find that they lead to the ciflern of the chyle. 70 1 . The interior fabric of the liver is more obfcure. Through the whole fubftance of the liver go bundles of biliary veffels, of branches of the vena portarum, and of the hepatic artery. Each vefl’el has both its proper cellular texture furrounding it, and fimilar ligaments, by which it is tied to its fellow-veffels ; and, laflly, the whole bundle has its cellular texture placed round it. The branches of the vena cava lie on the outfide of the reft, being lefs accurately received into the fame bundle. Laftly, the ultimate fmall branches of the vena porta- rum, cava, and hepatic artery, together with the bilious duels, which we fhall foon deferibe, are united together by means of the cellular fubftance (696.), into a fort of mulberry-like bunches, of an hexagonal fhape, fur- rounded with a lax cellular texture. In thefe bunches, likewife, there are mutual anaftomofes betwixt the por- tal branches and hepatic artery, with the roots of the vena cava on one fide, and the firft origins of the pori biliarii of the liver on the other fide ; which laft demon- ftrate their inofculations by anatomical injedlions, for liquors injedled by the vena portarum return again through the porus choledochus. 702. Many eminent anatomifts have taught that the fore-mentioned bunches are hollow, having arteries and veins fpread upon their external furface, and depofite the bile into their cavity, after it has been fecreted from the branches of the vena portarum. For this they al- lege arguments taken from the comparative anatomy of brutes, whofe liver is made up of more round and definite bunches ; and from thofe difeafes which de- monftrate cells and round tubercles, filled with lymph, chalk, and various kinds of concreted matter. To this they might have added the thick fluggifh nature of the bile itfelf, by which it is related to mucus, and the ana- logy of the follicles of the gall-bladder. 703. But 370 LIVER. Chap. XXIV. 703. But greater acuracy in anatomy will not allow any follicles into which the Imali fecretory veffels open ; for fuch would intercept the courfe of anatomical in- jections, and give us the appearance of knots interme- diate, betwixt the fecretory velTels and the biliary pores, which we have never yet been able to fee: for the wax flows immediately, without any interruption or effufion, into a cavity in a continued thread from the vena por- tarum into the biliary ducts. But, again, a follicular or glandular fabric is not allowable in the liver, from the great length of the biliary ducts. For all follicles depofite their contents into fome fpace immediately ad- jacent ; and are unfit to convey their fecerned fluid to any length of courfe, as they deftroy fo great a part of the velocity received from the arteries. Laftly, the ve- ry common prelfure which we mud fuppofe to be on thefe bunches of kernels would fo crufh them-, that no alTiftance could from thence be brought to promote the motion of the excretory duCls. Concretions and hydatids are formed in the cellular fubflance ; and, laftly, the bile, when firft fecreted, is fufliciently fluid. 704. Again, we are perfuaded that no bile is fepa- rated from the hepatic artery, becaufe the peculiar ftruffure of the vena portarum would be ufelefs if it fe- creted nothing. Its office in fecretion appears plainly by the continuations of its branches with the biliary duffs, in a manner more evident than that of the artery: but it appears by experiments, alfo, that the biliary fe- cretion continues to be carried on after the hepatic ar- tery is tied ; add to this the largenefs of the biliary dufls, in proportion to fo fmall an artery, with the pe- culiar nature of the blood collefled in the vena porta- rum, fo extremely well fitted for the formation of the bile. For w’e have already feen that it contains oil, which abounds more in the bile than in any other hu- mour of the body; for it takes in the faponaceous wa- ter of the ftomach by the abforbing veins, together with the fubfetid alkalefcent vapours of the abdomen, which tranfpire through the whole furface of the inteftines, fto- mach, Chap.XXIV. liver. 371 mach, omentum, liver, fpleen, and mefentery, which are abforbed again by the veins, as we know by incon- teftable experiments of anatomy ; and, finally, the alka- lefeent femiputrid acrimonious humidity from the fasces while they continue to thicken in the large inteftines, which is taken up by the internal haemorrhoidal veins, from whence that bitternefs, alkalefcent and putrefeent difpofition of the bile is derived. But in the blood of the hepatic artery, we can find nothing peculiarly fit for the fecretion of bile, or analagous to its nature. 705. Since, therefore, the vena portarum conveys the blood ready charged with biliary matter, fit to be fecreted in the leaft acini (704.), and from thence there is an open free paffage, y/ithout any intermediate fol- licles, from the ultimate branches of the vena porta- rum into the beginning roots of the biliary dudls, and that the humours driven into the vena portarum may eafily chufh this paffage, the bile will be expelled from thence by the force of the blood urging behind, as well as by the auxiliary force of the diaphragm prefling the liver againfl the reft of the vifeera in the very full ab- domen (689.), and again, contraded in exfpiration, it will be forced into the larger branches, and laftly into two trunks of the larger biliary du£t of the liver ; which trunks meet together in one upon the vena portarum, in the tranfverfe foffa of the liver, near the anonymous lobule. 706. The fabric of this dudl is made up by a ftrong nervous membrane like that of the inteftines, over which is fpread an external and internal cellular membrane, and is internally lined with a loofe villous tunic, elegant- ly reticulated, but afperated with many fmall pores and finufes, and continued with that of the inteftine itfelr. But there is here no mufcular fabric apparent. From experiments it appears to be endowed with a moderate degree of irritability. That it is vaftly dilatable, is fhewn from difeafes. The fame feem alfo to fhow that this dudt is endowed with a very (harp fenfation. 707. The hepatic dud, thus formed, goes on upon Z z th?i ^72 LIVER. Chap.XXIV-, the vena portarum, more to the right than the artery, towards the pancreas ; and then defcending obliquely, | covered by fome part of that gland, it goes to the lower part of the fecond flexure’ of the duodenum, and is in- serted backward about fix inches from the pylorus, through. an oblique oblong fmus made by the pancre- atic diidl, into which it opens by a narrov; orifice. The faid finus runs a great way through the fecond cellular coat of the duodenum obliquely downward ; then it perforates the nervous coat, and goes on again oblique- ly betwixt it and the villous tunic ; and, laftly, it opens into a protuberant long wrinkle of the duodenum. Thus there is almofl; the length of an inch taken up be- twixt the firfl; infertion and the egrefs of this duff through the coats of the duodenum, by a finus which Surrounds and receives the dudtus choledochus, in fuch a manner, that -when the coats of this inteftine are di- ftended by flatus, or clofely contracted by a more vio- lent perillaltic motion, the opening of the du£t mull be consequently comprefled or fliut ; but when the duo- denum is relaxed and moderately empty, the bile then has a free exit. Any regurgitation from the duode- num is hindered by this obliquity and wrinkling of the duft, eafily preflfed together or clofed and joined with a quick fucceflion of frefli bile defcending perpendicu- larly from the liver. Nor does wind inflated into the inteftine find any paflfage into the duct. 708. But, in the portae themfelves, this common duft receives another lefs canal of the fame kind, which lies for a good w’ay parallel wdth itfelf from the gall-bladder, making its infertion in a very acute angle ; and this, V'hich is called the cyftic duft, from its origin, is fome- times firft increafed by another fmall dud from the he- patic before its common infertion. This dud is form- ed by the gall-bladder as a peculiar receptacle for the bile given to mo ft animals ; but is abfent in fome, efpe- cially thofe of a fwifter foot, and perhaps only in fuch of thefe as are herbivorous : it is placed in an excava- tion of the right lobe of the liver (6^2.), to the right Chap. XXIV, LIVER, 373 fide of the anonymous lobule, in fuch a manner, that in infants or children it lies wholly within the edge of the liver, but in adults projedls confiderably beyond, lying upon the intellinum colon. Its fituation is almoft tranfverfe from the fore to the back parts j its neck afcends a little upwards. 709. The figure of the gall-bladder is variable, but in general like that of a pear, terminated in its forepart by an obtufe hemifpherical end, which is impervious, gradually diminilhing backward ; the neck or tip of this truncated cone being infleded upwards againft itfelf once or twice, and tied together by the cellular fub- fiance belonging to it, makes then another fmall flexure upward, and begins the cyftic dud ; which from thence goes on towards the left fide to the hepatic dud. With- in this dud there are many protuberant wrinkles, for- med by the numerous cellular bridles which tie them together ; and thefe wrinkles, conjundly in the dry gall-bladder, reprefent a kind of fpiral valve ; but being altogether foft and alternate in a living perfon, they do not flop, only lelfen the courfe of the bile, as we are af- fured from experiments, by prelTing the gall-bladder, and by inflations. Bcfides, it is reticulated like the gall-bladder itfelf. 710. The outermofl coat of the gall-bladder covers only.its lower fide, being the common covering of the liver itfelf ftretched over the gall-bladder, and confin- ing it to the liver within its proper finus. The fecond coat is the cellular fubftance, and of a ioofe texture. The third coat has fometimes fplendcnt fibres, chiefly longitudinal; but fome obliquely interfering each o- ther in various direrions. At other times it has none at all ; fo that we may doubt of its mufcular nature, efpecially as the irritability of the gall-bladder is flow and obfcure. Next to thefe come the nervous coat, then the fecond cellular, and lafl; the villous tunic; which are all found here as in the inteftines, . except that the lafl, in the gall-bladder, as well as in the biliary durs, is reticulated and full of cells. Within the gall- Z z 2 bladder. 374 LIVER. Chap. XXIV. bladder, but more efpecially about its neck and middle part, we obferve muciferous pores, capable of receiving a horfe-hair ; and befides thefe, the exhaling arteries difcharge fome quantity of a watery humour into the cavity of the gall-bladder, as we obferve in other cavi- ties. 7 1 1 . All animals, between their gall-bladder and liver, or between the duels coming from both, have, befides fome peculiar openings in the gall-bladder, into which fome dudls originating from the liver, or tue hepatic biliary duft, difcharge their contents. In man- kind thefe du£ls have not been fhown by any certain experiment, and the gall-bladder is eafily looled from the liver, without a drop of bile diltilling either from it or from the liver. There is alfo a thin v/ater in the bladder as often as the cyftic du£l is obftrufted. 71 1. The bile flows both out of the bladder and liver, according to its nature, as long as there is no impediment in its way ; fo that both duds fwell when that paflfage is obftruded, and the cyflic lies in a firaight line with the choledochus. Nor is it credible that all the bile fhould be diverted into the gall-bladder before it flows into the duodenum. There is not a perpetual obftacle which hinders the efflux, and peculiarly refills the hepatic bile, and admits the cyflic ; the paflfage into the dudus choledochus is larger and ftraighter, the dudus cyfticus much lefs than the hepatic, nor is that dud fo well formed for receiving all the bile ; the choledochus being much larger than the cyflic dud, cannot therefore be made only for the reception of its bile. There are many animals in which the hepatic dud difeharges its contents into the intefline without any communication with the cyftic. In living animals, even when the cyftic dud is free, the bill appears to de- feend into the duodenum with a perpetual current. That the quantity is very confiderable, appears from the magnitude of the fecretory organ, and the excre- tory dud, fo many times larger than the falival ones ; from difeafes, in which four“ounces of the cyftic bile only Chap.XZJV. L I V E II. - 375 only have flowed out duly through an ulcer of the fide. But the hepatic bile goes into the bladder, as often as there is any obftruclion in the duodenal finus, from flatus or any other caufe comprefling the exit of the duftus choledochus. Accordingly, we find it ex- tremely full, whenever the common biliary du£l is ob- flrufted or compreffed by fome feirrhous tumour, whence the gall-bladder is fometimes enlarged beyond all belief; and if the cyftic du£t be tied, it fwells be- twixt the ligature and hepatic du£t ; and' in living ani- mals, the hepatic bile vifibly diftils into the wounded gall-bladder, even to the naked eye. The retrograde angle, or dire£lion of this duQ:, is not repugnant to fuch a courfe of the bile; for a very flight preflure urges it from the liver into the gall-bladder ; and even wind may be eafily drove the fome way, more efpeci- ally if the duodenum be firft; inflated. Nor does there feem to be any fort of bile feparated by the gall-blad- der itfelf. Whenever the cyftic duct is obftrucled by a fmall ftone, or a ligature made upon it, we find nothing feparated into the gall-bladder more than the exhaling moifture, and a fmall quantity of infipid mu- cus fecreted from the follicles (710). In many ani- mals, we meet with no appearance of any gall-bladder, when at the fame time there is a plentiful flux of ftrong well prepared and falutary bile difeharged into their inteftines. Again, it does not feem probable, that the cyftic branch of the vena portarum can feparate bile into the gall-bladder; for that vein in itfelf is a mere re- condudory veflTel : nor can any be feparated from the hepatic artery ; for it muft be vaftly beyond probabi- lity, that fuch a ftrong bile as that of the gall-bladder fliould be feparated from a milder blood than the more foft hepatic bile prepared from the blood which is moft fit for that purpofe (704). 712. Laftly, the bile flows alfo from the gall-bladder to the liver, and at length returns into the blood when its paflage into the inteftines is totally intercepted, fometimes alfo from a caufe latent in the nerves. This paflage 37^ LIVER. Chap. XXIV. paffage Is pernicious, and produces the jaundice ; which, therefore, ftones thrown out of the inteftines cure, by reftoring its free courfe into the duodenum. 713. Therefore a portion of the hepatic bile being received into the gall-bladder, there ftagnates, only a little fhook by the refpiration ; and there, by degrees, ex- hales its thinner parts, which, as we fee, filtrate through and largely penetrate the adjacent membranes. The remainder, as being a fluid of an oily fubalkaline nature, digefting in a warm place, grows fliarp, rancid, more thick, bitter, and of a higher colour : for this is all the difference betwixt the cyftic and hepatic bile; which laft we find weaker, lefs bitter, lighter coloured, aiid of a thinner confidence, while it remains within its proper hepatic duels. That this difference betwixt them pro- ceeds only from flagnation, appears from fuch animals as have only a larger porus hepaticus, inllead of a gall- bladder ; for here we find the bile, which ftagnates in the larger hepatic pore, is confiderably more bitter than that in the fmaller pores of the liver; as for ex- ample, in the elephant. But the gall-bladder gives this particular advantage, that it receives the bile when the ftomach, being empty, has no call for it, that after- wards it may be able to return it in greater plenty, when we principally want it for the digeftion of the aliments now flowing in great quantity into the duodenum. This flow of the bile is quicker in proportion through the cyftic du6l, as the fedion of that dud is lefs than the feclion of the gall-bladder. 714. The gall-bladder, indeed, hardly touches the ftomach, but the beginning of the defeending duode- num. But when the ftomach is extremely diftended, and in a very full abdomen, it makes a confiderable preffure both upon the liver and duodenum; by which the gall-bladder is urged, and its bile expreffed. Thus the bile flows through a free paffage, from the gall- bladder into the common duel, and the duodenum ; and this it does more eafily in perfons lying on their back; in which pofture the gall-bladder is inverted, with Chap. XXIV. LIVER. 377 with its bottom upward. Hence it is that the gall- bladder becomes fo full and turgid after falling. The cxpulfive force of the bile is but little more than that of the preffure received from the ftoinach and dia- phragm ; for as to any mufcular force refiding in the fibres of the proper membrane, which may be thought to contrad; the gall-bladder, it mull be very weak and inconfiderable. 715. The hepatic bile is always bitter, but the cyftic is more fo ; always vifcid ; of a full yellow colour, with a tindure of green ; mifcible, by triture, either with water, oil, or vinous fpirits ; coagulable by mineral acid liquors ; dilfoluble by alkalies, efpecially the volatile kinds ; and extremely well adapted to diffolve oily, re- finous, or gummy fubllances ; quickly putrefying, and by putrefadion i'pontaneoufly degenerating to a mufk- like odour. Its chemical analyfis, and experiments of mixture with various fubftances, demonftrate, that it contains a large portion of water, and a confiderable quantity of inflammable, oil, which, in (tones of a gall- bladder, appears very evidently. The bile, therefore, is a natural foap ; but of that fort which is made from a volatile faline lixivium, mixed with oil, and has its wa- ter along with it. This, therefore, being intermixed with the aliment, reduced to a pulp, and flowly ex- preffed from the ftomach by the periftaltic force of the duodenum and preffure of the abdominal mufcles, in- corporates them all together; and the acid or acefcent qualities of the food are in fome meafure thus fubdu- ed, the curd of milk is again diflblved by it into a liquid, and the whole mafs of aliment inclined more to a putrid alkalefcent difpofition : it dilfolves the oily matters, fo that they may freely incorporate with the watery parts, and make up an unifoi-m mafs of chyle to enter the ladleals ; the furrounding mucus in the in- teftines is hereby abflerged and attenuated, and their periftaltic motion is excited by its acrimony ; all which offices are confirmed, by obferving the contrary effedls from a want or defe^l of the bile. Nor is the hepatic bile S?8 LIVER. Chap. XXIV. bile fufficient to excite the neceffary motion of the in- teftines, if the cyflic is wanting ; both which are of fo muchufe and importance to the animal, that we find, by experiment, even the ftrongefl will perilh in a few days, if the flux of bile to the inteftines be intercepted, by wounding the gall-bladder. 716. Thus it flowly defcends along with the ali- mentary mafs ; and having fpent its force, or changed its bitternefs by putrefaction, moll of it is afterwards excluded together with the faeces ; but probably fome of the more fubtle, watery, and lefs bitter parts, are a- gain taken up by the vena portarum. It returns the lefs into the ftomach, becaufe of the afcenc of the duo- denum, which goes under the ftomach, with the re- fiftance it meets with from the valvula pylori, and the advancement of the new chyle which the ftomach adds to the former : in man, however, it frequently enters ; and always in birds. The bile is of a fweet foft nature in the fetus ; for in them the faeces are not very fetid to fupply putrid alkaline vapours to the liver, nor are there any oily or fat fubftances abforbed from the inteftines. As the bile is a vifcid fluid, and thickens by inaftivity of body in fat animals, and in us from the fame caufes, efpecially when the blood moves languid from grief ; fo it eafily coagulates into an hard, fome- what reftnous, and often ftony fubftance, infomuch that ftones of the gall are much more frequent than thofe of the urinary bladder, as we are taught by our owm experiments. Its ufe is manifeft, as, being tritura- ted with the aliments, it diflblves oil, rcfifts acidity, and thus ftimulates the inteftines to contraction. 717. The ufe of the liver, befides fecreting the bile, is manifeft in the fetus. It feenis to tranfmit the blood brought back from the placenta, and to break its force. Even in an adult perfon it has the fame ufe though lefs manifeft, namely, to retard the return of the blood coming back from the vifcera appointed for preparing the chyle, v CHAP. Chap. XXV. INTESTINES. 379 CHAP. XXV. Of the Small Intestines. 7i 8."|3 Y the /mail mtejlines^ anatomifts underftand one continued almoft cylindrical tube, but vvhofe tranfverfc fcclion is nearly oval, the obtufe end being towards the unconneded fide of the inteftine. This tube is continued from the end of the ftomach, the right orifice of which it embraces (6 25. ) ; and, being produced thro’ a long trail, ends by an expanfion into a a much larger intefiine. Anatomifts have ufually rec- koned three fmall inteftines, tho’ nature has formed but one. However, the duodenum has generally pretty cer- tain bounds, terminating with its end in that part of the abdomen which is above the tranfverfe mefocolon (659.) But that finall inteftine which lies below this mefocolon, commonly called jejunum, has no cer- tain mark or boundary to feparate it from the lower portion, which is commonly called the ilium : although the former, abounding more with valves and blood- veffels, has, in general, a more florid appearance, and is furniflied with longer villi internally ; and the ilium again, having fewer of thofe vafcular ramifications, like little trees, abounds more with a fort of minute glan- dules : however, thefe diflerences infenfibly difappear one in another, without affording any certain limits be- twixt the two inteftines ; but is great in the extreme terminations, but obfcure in the neighbouring parts. 719. The duodenum feems to be denominated from its length. It is larger, and more lax or open, than fhe other fmall inteftines, more efpecially in its firft flexures 5 which is partly owing to its not being circumfcribed in fome places with any external membrane, and in other places only for a fmall compafs. It is florid and ten- der, having its flefliy fibres fometimes of a confider- able thicknefs. Its origination begins round the ring- 3 A like 3^0 INTESTINES. Chap. XXV, like valve at the mouth of the pylorus ; from whence being undulated or inflefted, but generally in a tranf- verfe courfe, to the right downward and backward in an empty ftomach, it goes under the gall-bladder, to the neck of which it is contiguous (7 14.) From thence it defcends obliquely and backwards to the right fide as far as the lov/er plate of the inefocolon, where it is per- forated by the biliary duft, and in that courfe is intercep- ted betwixt the upper and lower plate of the inefocolon. From thence at laft it proceeds tranfverfely, but a little afcending behind the pancreas and large mefenteric vef- fels, and goes on to the left fide along with the left renal vein, where, going out from the duplicature of the me- focolon, and bending round before and to the right of the faid veffels, it palfes through a peculiar foramen, in which the mefentery and left part of the tranfverfe me- focolon adhere to the intefline itfelf j from thence it de- fcends forward, towards the lower part of the abdo- men, into which it advances under the denomination of the. jejunum. The largenefs of this intefline, with its afcent from the infertion of the biliary duel, joined with the confequent fold about the root of the mefen- tery, caufe a remora of its contents, by which the bile, pancreatic juice, and alimentary pulp, are here firfl in- timately blended together. 720. The reft of the fmall intefline, having no cer- tain feat or divifion, is continued by innumerable and uncertain convolutions, not to be deferibed, fo as to fill out the lower part of the abdomen and pelvis fur- rounded by the colon on each fide, and lies between the bladder and uterus below. 721. The fabric of the fmall intefline is almoft the fame with that of the ftomach and oefophagus. Its ex- ternal coat, excepting part of the duodenum, is recei- ved from the peritoneum or mefentery, applied on each fide to the obtufe end of the oval intefline, and fepa- rated by the intervening cellular fubflance, which is often repleniflied with fat, but more clofely embraces or adheres to the mufcular fibres in the unconnected fide Chap. XXV. INTESTINES. 381 fide of the inteiline ; where the outer and mufcular coats flridly cohere, without (hewing any remarkable diffe- rence from what we have obferved of them in the (lo- mach. By this external membrane, and by the me- fentery (661.), the inteftines are fupported with a confiderable degree of firmnefs, at the fame time that they are allowed every way a free liberty for motion. 7-2 2, But the fabric of the ?nufcular coat differs from that of the ftomach, in the figure of its fibres. The larged and mod confiderable body of thefe fibres is circular, cloathing the tube on each fide, refembling each other both in their parallel difpofition and appear- ance, which is that of imperfeft arches or fegments of circles, cemented one to another, paler than other muf- jcular fibres, and yet remarkably contradfile. The longitudinal fibres are, in the fmall intedines, much fewer in number, fcattered round their whole extent, interfperfed with the former, and are more efpecially fpread upon the loofe or unconnedled fide of the in- tedine. 72:^. Within the mufcular coat, is feated the fecond cellular, of a larger or loofer extent here, as it was in the domach ; and this being fpread on all fides round the nervous coat, which it includes, is, in us, feldom replenifhed with fat. But the nervous coat, being like that of the domach, ferves as an internal foundation or fupport to the whole intedinal tube ; being compofed chiefly of compadled fibres, which, by iiiflation, may be parted one from another, fo as to refemble a web- like or cellular fubdance. Next to this, follows the third cellular coat, which is almod like the fecond ; and then the innermod or villous coat, which differs, in feveral refpefts, from that which we deferibed in the ilomach : for fird it is folded on all fides into wrinkles that are femicircular,the extremities of which correfpond one to another oppofitely, but uncertain in their pro- portions ; into which wrinkles the nervous coat (light- ly enters, whild the red of the intermediate fpace be- twixt the folds of the villous tunic is filled up by the 3 A 2 third 382 INTESTINES. Chap.XXV. third cellular ftratum. Thtk plica or folds of the in- teftine begin within one inch of the pylorus, and are mod numerous in the fir ft and middle part of the inte- ftines, but gradually grow fewer in number downward. Here each fmall twig of the artery, which is fpread in the cellular fubftance, upon the convexity of the inte- ftine on one fide, is anfwered by another twig, difpo- fed in the fame manner, on the oppofite fide. The pli- cae are, at firft, confufed in the duodenum, and after- wards become more confpicuous as the inteftine ad- vances ; but the appearance of acute imperfect circles or valves is given to them by anatomical prepijration, in which their natural ftate is altered. They are indeed foft, and eafily inverted, fo as to give way, in any di- rection, to the courfe of the alimentary pulp; upon which, however, their number has fufficient influence to retard the motion, while, at the fame tierje, they en- large the furface of the villous membrane. 724. We come now to the true villous coat, which we call fo in other parts by analogy. Namely, the whole internal furface of the inteftine and its valves, together with the fmall cavities interpofed betwixt them, fend out on all fides innumerable fmall fluctua- ting fleeces like a piece of velvet, the extremities of which are obtufely conical productions of the inner coat of the inteftine, and from the cellular fubftance, intercepted between the duplicature, and from the fmall veffels and nerves wrapped up in that cellulofity, and likewife from the laCleal veifel which we fliall after- wards fpeak of, fo as very much to refemble the papil- lae of the tongue, only of a fofter texture. 725. The chief fmall veffel of each villofity is an oval veflfel opening by a flender duCl in the furface of the villous coat, often filled with milk, which the neigh- bouring fmall veffels every where furround. 726- In the internal furface of this villous coat, open an infinite number of pores ; fome larger, others fmal- Jer. The former lead to fmall confpicuous fim )le glan- dules of the mucous kind, feated in the fecond cellular ftratum, Chap. XXI. INTESTINES. 383 ftratum, and like to thofe of the vafcular follicles feated in the mouth and pharynx, which like wife open with numerous patulent orifices into the inteflines. In the duodenum thefe are affembled together in feveral places, without running together ; nor can they always be demonllrated ; but many of them are quite folitary or afunder in the ilium, or often affembled only a few together ; though, in many places, a confiderable num- ber of the fame kind are affembled together, into a little army of an elliptical figure. They have every where a villous membrane. 727. 'Throughout the whole tract of the inteflines are found pores of a lefs kind furrounding the bafis of the villi, and mofl ample or confpicuous in the large inteflines, where they were firfl obferved; but have been lately difcovered, by a more careful inquiry, in the feali inteflines likewife. Thefe alfo feem to depofite a liquor of the mucous kind. 728. The vejfels of the fmall inteflines are very nu- merous. The common larger trunk belonging to the intefline that occupies the fpace below the mefocolon is called the mefenteric artery ^ being the largefl of thofe produced by the aorta above the renal arteries. This, defcending behind the pancreas to the right fide of the jejunum, and before the colic branches, fends out more especially a long trunk to the bottom of the mefentery and termination of the ilium towards the right fide ; as on the left fide it fends out numerous branches, the firfl and lafl being fhorter, the middle ones longefl. Thefe lafl, fubdividing into fnialler, join with thofe in their neighbourhood in fhape of convex arches j which again fend out other branches united in like man- ner, to the repetition of almofl the fifth feries-of arches, until the lafl fend flraight and very numerous branches to the intefline ; where, forming their lafl convexity, their numerous fmall branches are detached on each fide the intefline. 729. The divifion of thefe branches in the intefline, is much after the fame regular manner j fo that one comes 384 INTESTINES. Chap. XXV. comes out from the mefentery, through the cellular fubftance, on the forefide of the inteftlne, as the other does, in the like manner, upon the lower fide ; which, having given fmall branches to the outermoft and flefliy coat, come to the fecond cellular one : there the ante- rior trunk, running out towards the obtufe vertex of the inteftinal ellipfis, is continued ftraight into the pofterior branch fimilar to itfelf; and, according to its fize, gra- dually fends olf fmaller fhrub-like twigs, inofculating with each other, and with their oppofites, by innume- rable circles. From this arterial net-work, fmaller twigs penetrate from the nervous tunic into the third cellular ftratum, and are, with that, continued to the ultimate extremities of the villi, where they at laft open by exhaling orifices, and difcharge a w'atery humour into the inteftine ; for this continued courfe is eafily imitated and fliown, by injedling water, fifii-glue, or mercury. But late induflry has difcovered, that thefe arterial extremities firfl; open into an hollow veficle ; from whence their depofited juice flows out through one common orifice. For the reft, the arteries in this part form numerous reticular inofculations, that, by a- voiding all obftructions, they may be able to fuppiy the inteftines equally on all fides ; and that any obftruding matter may, upon occafion, be eafily removed back from the narrower extremities to the larger arterial trunks. 730. The laft trunk of the mefenteric artery inofcu- lates with the ilio-colic. The duodenum has various arteries. The firft and uppermoft from the right he- patic goes round to the convexity of the inflexure of this inteftine, which it fupplies in its way to the pan- creas, and inofculates together with the lower or left pancreatico-duodenal artery, which makes a like arch round the curvature of the duodenum into the pancrer as ; being, at laft, inferted into the lower duodenal ar- teries, produced by the mefenteric in its paflTage before this inteftine. As to the fmall arteries which go from the fpermatics to the duodenum, and from thofe of the renal Chap. XXV. INTESTINES. 385 renal capfule, we defignedly omit any further notice of them. 731. The mefenteric veins meet all together, in the fame courfe or difpofition with the arteries, in the rae- fenteric trank of the vena portarum ; except the right duodenal vein, which goes immediately into the trunk of the vena portarum itfelf; and except thofe fmali veins which run in company with the fmall arteries f7 3o.) and are inferted into the fpermatics and lum- bals. Nor have I been able to difcover any other veins of the mefentery arihng from the cava. It is a property in common to all thefe veins to be without valves, and to make free communications with the arteries. Thofe veins in the villous coat, which is for the moll part compofed of veins, abforb thin humours from the in- tefline ; as appears from the injeftion of watery liquors, which readily run through the fame way ; and, from analogy, in aged perfons, in whom the mefenteric glands, and confequently the ladeals that pafs through them, are frequently doled up ; add to this, that birds have no ladeal veffels, and the celerity with which wa- tery liquors pafs to the blood and through the kidneys, compared with the fmallnefs of the thoracic dud, chiefly from thofe experiments which have confirmed by ocular demonllration the paflage of water from the cavity of the inteftine into the vena portarum. 732. The nerves, tho’ fmall, are numerous, whence the intellines receive no little degree of fenfibility ; they arife from the middle plexus of the fplenic nerves, and, embracing the mefenteric artery, play round it in great numbers, wrapped up in a very denfe cellular plate. The duodenum has likevvife fmall nerves from the po- fterior hepatic plexus of the eighth pair. From this great fenfibility of the intellines it is probable, that the ultimate branches of the nerves penetrate into the third cellular coat. 733. From the exhaling arteries dillils a thin watery liquor into the cavity of the intellines, like the juice of the^ftomach, not acrid, but faltifli. The quantity of this liquor 386 INTESTINES. Chap.XXV. liquor may be computed from the large extent or fum of all the excretory orifices, and from the feftion or light of the fecretory artery, larger than which we fee no where in the body ; add to this, the laxity of the parts perpetually kept warm and moift, and the copi- ous diarrhoea or watery difcharge that often follows the ufe of purgative medicines. But the mucus arifing from the pores or cells before-mentioned (726, 7:7.) ferves to lubricate and defend the internal furface of the villous membrane, and to guard the fenfible nerves from ftrongly acrid or pungent particles. Hence we fee, it is more abundant at the beginning of the larger inteilines, becaufe there the mafs of aliment begins to be more feculent, acrid, and tenacious. 734. The mixture of this liquor with the pulp-like mafs of the aliment, together with the bile and pancrea- tic juice, is made by the motion of the furrounding mufcles of the abdomen; but this force is quite fmall, and unfit for moving forward the aliments. But for this purpofe ferves efpecially the perijlaltlc motion, which is more particularly firong and evident in the fmall in- teftines. For any part of the intefline, irritated by flatus or any fharp or rough body, contracts itfelf, even after death, molt violently in that part where the fti- mulus is applied, in order to free itfelf from the offend- ing or diftending body, which it expels into the next open part of the lax intefline ; where, being received, it is again propelled forward, by exciting a like flimu- lus and contraction as before. This contracting mo- tion of the inteflines is made in various parts of the gut, either fucceffively or at the fame time, wherever the flatus or aliment excite a flimulus ; and this, without obfer- ving any certain order. So well fitted, however, are the inteflines for this motion, that they emulate, and even ex- ceed, the irritability of the heart, or at leafl are fcarcely exceeded by it. When they are not irritated, they re- main at refl, as 1 have often obferved ; and we may fuppofe this to be the caufe why the fat remains in the belly. The air ads chiefly as a flimulus to the intef- tines. Chap. XXV. INTESTINES. 387 tines, next to it is the aliment, and laftly the bile. This motion is performed by a v.'onderful fort of alternate creeping and revolution of the inteilines, which diffec- tion eafily demonftrates in living brute animals, and unhappy cafes of wounds in the abdomen and ruptures have manifefted in the human fpecies. And lince here, among fo many inflexions, the v.'eight of the aliment is but of little force, it eafily afcends or de- fcends through the irritated inteltine, which thus emp- ties itfelf. From hence the antiperijlaltic motion is in- telligible, by which the pulp of the alimentary mafs is oftener or longer applied with a gentle force to the triture of the intefline, to the exhaling diluent liquor, and to the mouths of the abforbing veins. But all the contents of the intefline are determined downward to the large inteflines, becaufe the flimulus begins above, from the left opening of the ftomach ; and fo, by the fucceflion of new chyle, repeating the flimulus above the contraflion, it defcends, when there is no refiflance made to it, into the lower part of the ileum, at its open- ing into the colon : here the loofe part of this intefline readily receives what is preffed into it by the con- traftion from above, and as eafily unloads itfelf into the large unaflive caecum ; from whence it is again- repel- led upward, and in part urged on by the preflTure of the fucceeding mafs. Anatomifls obferve, that this motion is made flronger downward than upward, and that the fuperior parts of the inteflines are more irri- table than the lower. But as often as an infuperable obflacle refills the paffage of the aliment, there will be the feat of the principal contraftion, and the ali- ment likewife is driven upward from the valve of the colon through the whole length of the inteflines, into the flomach, and laflly into the mouth. 735. This periflaltic motion of the inteflines is per- formed by the conflridlion of their circular fibres, which exadlly know how to empty the tube, without injuring the intefline againfl pins, needles, or any other fharp bodies lodged within their contents, which they 3 B tenderly 388 INTESTINES. Chap. XXV. tenderly promote forward. But the revolutions of the inteftines, drawn upv/ard and downward, and the Itraightening of crooked parts of them one before an- other, which is fo remarkably confpicuous in brute animals, are performed by the long fibres, which we fee contradt thernfelves at the feat of the prefent ftimu- lus, and dilate the following portion of them to receive what enfues. By the fame contraction, the villous membrane of the intefiines, within their cavity, is urged and reduced into longer folds ; whence the mucus is expreffed and applied to that part of the alimentary mafs, where it was requiied by the force of irritation and ftimulus. Thefe long fibres frequently make intro-fufeeprions of the Inteftines, and generally w'ithout any bad confequences, by drawing up the contradfed portion of the inteftine into that which is loofe, in fuch a manner, that the former is furrounded by the latter, which is relaxed. 736. The alimentary pulp, therefore, diluted with the pancreatic juice and that of the inteftines, intimate- ly mixed with the faponaceous bile and circumjacent mucus, is more perfectly diftblved than by the effi- cacy of the flomach, in proportion as the fides of the inteftines come into a larger contact, and approach nearer together ; to which add, tiie longer feries of the periftaltic motions, and the greater quantity of dif- folving juices. In this manner, the alimentary pulp, intermixed with air, forms a froth, without any kind of fermentation, wfiich air is the fame with what we commonly eruftate from the ftomach ; but yet, at the fame time, the acid or acefeent force is fubdued, while the oily or fat parts, diftblved by the bile (715.), inter- mix with the watery juices, and put on the chyle its ufual milky appearance, like an emulfion, of a bright colour in the duodenum, at the firft entrance of the bi- liary duct ; from whence downward it clofely adheres to the villous coat of the fmall inteftines. But the ge- latinous juices of flefti meats, diluted with a large por- tion of water, and likewife from their own fubviftid na- ture. Chap. XXV. INTESTINES. 389 ture, do more particularly adhere to the villous coat, and enter it in the way of abforption. So water and watery liquors are all very greedily drank up by the veins; and yet the feculent remains never grow thick in the fmall intdfines, as far as I have been able to ob- ferve, becaufe the watery part is repaired by the arte- rial vapour and mucus ; nor do they become fetid in any confiderable degree, as well becaufe of the great quan- tity of diluting juices, as becaufe the quick progreffion will not allow them time enough for a putrefadion. Thofe remains, which are of a mure earthy, grofs, and acrid difpofition, which were excluded by the mouths of the absorbing lacfeal orifices, do, by their weight, or by the mufcular contractions, defcend flowly into the large inteftines, fo as to complete their whole courfe in the fpace of about twenty-four hours. But within three, four, or a few more hours time, all the chyle of the aliment is commonly extraCled. 737. The confiderable length of the fmall inteftine, which is five or more times longer than that of the bo- dy, the great furface of the villous membrane increafed 'by folds, the incredible number of exhaling or abforb- ing veffels, the flow courfe of what remains through the large inteflines, and the great quantity of the inte- fcinal juice poured into the alimentary mafs, do all of them concur, in the fmall intefline, abundantly to per- form vdiat is required in the emulfions of the food for our healthy juices, and for their abforption into the lafteals and the mefenteric veins ; alfo for abfterfion of vifcidities from the intefline; for the avoiding adhefions and coagulations ; for the deflruCtion of any acid difpo- fition not yet fubdued ; and for the fubduing any veno- mous quality in many juices, w'hich, being direClly mixed with the blood, inflantly kill, but are thus fent in by the mouth without damage. Hence, in general, the inteflines are long in animals that feed upon any hard diet, but fliorter in carnivorous ones, and fhortefl in all thofe that live upon juices ; and, even in man, an uncommon fhortnefs dt the inteflines has been 3 B 2 known 390 INTESTINES. Chap. XXV. known to be attended with hunger, and a flux or dif- charge of fetid and fluid faeces. 738. The heat by which the aliment is fomented, and which is exceedingly proper for the folution of the gelatinous matter, and exciting a beginning putrefac- tion, is hence the principal caufe of the fetor which is gradually produced in the aliment ; thence alfo is the caufe of that thinnefs by which the ufeful part of the a- iiment is fitted for abforption. But the air alfo, inclofed in the vifcid aliment, operates here, as in the flomach, by breaking the cohefion of the aliments, if any yet re- main whole. The inteflinal water dilutes the little maflfes of aliment ; and if any hard part remains, this liquor foftens it by maceration. The bile being inti- mately mixed with oil, diffolves the fame, and renders it mifcible with water. CHAP. XXVI. Of the Large Intestines. 739.‘TTTH AT remains, after the chyle has been VV abftrafted, confifts of fome portion of the bile, but mucilaginous and degenerate ; fome part of the human mucilages ; mofl: of the earthy parts that were lodged in the food ; and all thofe parts which by their acrimony were rejected by the abforbing mouths of the ladleals, yet changed by means of putrefaction (736.); with all the folid fibres and membranes, whofe cohefion was too great to be overcome by the macera- tion and periftaltic motion in the inteftines. 740. All thefe remains pafs from the extremity of the ileum into the caecum, in which they are collected and. flagnate ; namely, the extremity of the fmall in- tefline, called the ileu?n^ applies itfelf obliquely, in fuch a manner, to the right fide of the colon, refting upon tli6 right ileum and its mufcle, that, in general, it a- feends in a curve, but more in its lower fide, and lefs Chap.XXVI. intestines. 391 in its upper, which is almoft tranfverfe. But finally, the nervous and villous parts of the ileum are fo ex- tended betwixt the departing fibres of the mufcular and nervous coat of the colon, as to hang pendulous within the cavity of this large inteftiiie, with a double eminent wrinkle or foft fold, compofed of the villous and nervous coat of the thick inteftine, and of the final! inteftine likewife, and of the interpofed flefliy fibres of the ileum and colon, joined together by a good deal of the cellular fubftance. The upper tranfverfe fold is Ihorter, as the lower is broader and more afeending, being conjoined together by a frnall production of the fame kind, more efpecially in the right fide, adjacent to them. Betwixt thefe two folds, the mouth of the i- leum opens, like a tranfverfe flit. But when this inte- fiine is inflated, the ftrufture of it changes very much, reprefenting thefe parts to us under the figure of mem- branes and hard valves. After the cellular plate has been entirely removed from them, the ileum comes clean out from the colon, and the valvular appearance is no more to be feen ; but if a large part of it only be drawn out, leaving a fmall portion inferted behind, it refembles a fphinfter. 741. Below the entrance of the ileum, at the diftance of fome inches, the great intefline defeends and forms a blind or impervious extremity, called the cacum, refting upon the ileum. From the lower part of this, towards the right fide, extends a fmall worm-like pro- cefs, in adults of confiderable length, like a long ex- tended cone or little, intefline, varioufly incurvated, fometimes downward, and full of fmall mucous glands, which pour out a gluey mucilage to the fmces ; but, in the fetus, the colon itfelf is extended into a conical ap~ pendix. But the weight of the fuperincumbent faeces, depreffing the fpace on the right fide of the appendix ; the ftrength of the cellular texture uniting the left part of the caecum with the ileum, of the flefliy fibres uni- ting both inteflines ; the very contraftile force of the ligamients j the fitnefs of the anterior fac of the caecum, which 592 INTESTINES. Chap.XX\T. which eafily receives the faeces from the inteftinum -ileum; all contribute to remove the appendix from the middle, and make it to go out from the left extremity of the colon: and thus is produced the thick and pen- dulous globe of the colon lying farthefl to the right fide, and which is proper to adult perfons. When, therefore, the remains of the alimentary mafs are fent from the ileum into the colon, they fall by their weight firll into the cavity of the caecum, or impervious bag- like appendix ; here, by ftagnating, and the warmth of the parts, they begin to putrefy, according to their particular nature ; and here, efpecially, the fetid fmell, obfervable in the execrements, begins. 742. The colon fs an inteftine altogether continu- ous, as one and the fame with the caecum ; namely, the largefi; of the great inteflines, and by much the ftrong- eft. Beginning upon the ileum (740.), it afcends over the right kidney, and lies under the liver, with an angle in the right hypochondrium ; being connected to the vifcera, on each fide, by the peritonsum. From thence it paffes under the liver and itomach, for the moft part, tranfverfely to the fpleen, under which it ftretches (676.), and in the deep recefs under the left ribs is of- ten twilled upon itfelf. From thence, again, continu- ing its defcent to the left ileum, it forms a large flex- ure (658.); from which flexure it is continued, in its lower part, through the pelvis, under the denomina- tion of redum. 743. The llru6ture of the colon is in general the fame with that of the fmall inteflines, but it has feveral things peculiarly differing from them. And firll, all the longitudinal fibres are collefted together into three bundles which run through the whole extent of the in- tefline ; and of thefe one, and that the largell, lies na- ked, the other arifes from the omentum ; and the third is contained in the mefocolon. Thefe are Ihorter than the inteftine, and contrad it fo that the nervous and villous membrane (744.) protuberates inwardly. Thefe fibres are conneded moll accurately with the external coat Chap. XXV. INTESTINES. 393 coat of the inteftines ; but in the intermediate places, and chiefly at the mefocolon, is feated the firfl cellular ftratum repleniftied with fat. At firft, being dilated, they adhere to the vermiform appendage. In the ex- tremity of the colon there are often only two ligaments, where the two leiTer join into one. They diffufe them- felves upon the redtum in fuch a manner as to occupy the whole. 744. Again, the flefliy and nervous coat, and third cellular llratum, with the villous tunic of the colon, are extended into much larger wrinkles in the parts be- twixt the ligaments, often proje