* ft" f- , -v ' * ♦ ‘ • • * 'V ■ - » ' ' • • * • ; *- m ,1 i, - H U M A N OSTEOGENY explained in T wo Lectures, Read in die Anatomical Theatre of the Surgeons of London. July the firjl and fecond \ anno 1731. In which not only the beginning and gradual increafeof th q bones of human foetuses are de- ferred ; but alfo the nature of offification is conlidered, and the general notion, That all bones are formed from cartilages , is de- monftrated to be a miftake. ByROBERTNESBITT, M. D. Fellow of the Royal College ^/Physician's, and of the Royal Society, and Reader of Anatomy at Surgeons Hall. The main Bufinefs of Natural Philofophy is to argue from Phenomena, "without feigning Hypothefes, and to deduce Caufes from Effetts , till we come to the very firjl Caujc , •which certainly is not mechanical. Sir Isaac Newton’i Opticks, xxviii. LONDON: Printed by T . Wood, and fold by W. Innys and R. Mangy, J. Pemeert on, E. Symon, J. Nooy. and C. Davis. m pcc XXXVI. w . . • > .. . ‘ . * * S %' ■ 5 :S^r ’?v-^ Digitized by the Internet Archive in 2016 https://archive.org/details/humanosteogeny01nesb D r James Douglas, Phyfician in extraordi- nary to the QUEEN, Honorary Fellow of the Roy. al College ^/Physicians, and Fellow of the Royal Society. HE character, dear Sir, which you have now for many years , of being as ca- a 2 pable DEDICATION. pable a judge of the truth and juftnels of all anato- mical performances, as a- ny age has produced, will, I doubt not, caufe my , readers to think all excu- l'es, both for printing thefe Leisures , and inl'cribing them to your felf/ entirely needlefs; when they are in- formed, it was byyourper- fuafions alone, that I was prevail’d on to revife, and thus make them public, af- ter they had for fome years lain by me difregarded. Your want of leil’ure to publifh the ofteology of adults, which you had ma- ny years fince nearly per- fected , DEDICATION. fecfed, caufed you to de- fpair of ever finding time fufficient to add ofteogeny to that work ; for which rea- fon you urged me to pub- lish what I had written on that fubjedt ; tho you knew it was compofed only for the ufe of the anatomical theatre. As I was, when I drew up thefe Lectures, en- tirely of your opinion, that little regard ought to be given to any thing advan- ced in anatomy, which is not demonftrable by pro- per preparations; I was ob- liged, in order to prove to my hearers the truth of my delcriptions , to make a large i DEDICATION. large number of prepara- tions very different from what I had ever l'een in a- ny anatomical mufeum, ex- cept that very curious one of profeflbr Albums at Ley- den. When you examined thofe preparations, you was pleafed to approve of them ; becaule each part, I defign- ed to defcribe,was prelerv- ed in its natural lhape and colour. Hence you was in- duced to believe me fuffi- ciently qualified to give the public better and truer re- prefentations of the vari- ous parts of skeletons pre- pared from foetuses of a dif- ferent age, than had been done DEDICATION. vii done by any writer on ofte- ogeny ; fince, as you juftly obferved, all their lculp- turesof fuch skeletons, hi- therto publilhed, having been taken from dried pre- parations, muft confequent- ly reprefent the parts very different from what they appear to be in a natural ftate. I allure you, nothing will encourage me lb much to purfue anatomical re- fearches, whenfoever lei- fureand opportunity ferve, as your approbation of what I now prefent you with ; which alfo will make me both expert the favourable fentiments of all other com- petent viii DEDICATION. petent judges, and think my felf iufficiently reward- ed for the time and pains already employed in fuch enquiries by, Dear Sir , Tour affectionate brother , and mojl obliged humble fervant, Robert Nesbitt. Bafmghall-Street, January IZ , 173^ T O T H E READER. S I N C E the firft of thefe Ledtures, which contains a Jhort account of the manner and caufe of bony pro - duSiions , was printed off, J I have had the pleafureof finding the notion^ which the fu- gacious Dr. Pitcairn entertained \ concern- ing the manner of offificationyo be in part agreeable to what I have there advanced [ Tho it feems , by his ?nentioning Gagliardi’j 1 fuppofed claviculi,/*? be founded chiefly on his mifaken account of the texture of bones . His words are , Superficies ofiium concentric^ nihil aliud funt, quam membrane plures fibi mutuo fiiperpo- fitae, quarum pori replentur corporibus duris efucco durante derivatis; ille fuc- cus per arterias advedtus (refluentibus per venas partibus fluidioribus) exfudat b ' in X To the Reader. in poros membranarum, quae circum- volutae os conflituunt. Pitc. Elem. Med. 1 . i. c. 5. § 81. So much of this account as relates to a juke impregnated Corporibus duris, or, as he afterwards exprejfesit , materia gypfea, being brought to ojflfying parts in the arteries , and the more fluid part of that juice returning by the veins, is entirely agreeable to what I have demonflrated from various ap- pearances of nature. But the exfuda- tion of thefe hard bodies, or gritty mat- ter, into the pores of the membranes, is altogether imaginary. Had this great man , qualified with fuch a phyflcal ge- nius, as he appears to have been, given himfelf the trouble of accurately examin- ing thefe parts, we might reafonably have expended from him almofl a perfeEl ac- count of this part of the animal cecono- my . But, alas l thus we frequently find the moft capable perfons leaft inclined to take the pains necejfary to fearch out real phenomena fufficient to ground their rea failings upon , and, therefore often attempting I o» XI To the Reader. attempting to fupply that defeSl by their lively imaginations. I thought it not necejfary , in order to illujlrate the fecond Lecture, to follow the example of Kerckringius, in giving fculptures of every part of a foetus of each month from the fecond after conception to birth ; becaufe thefe parts do not every month differ in Jhape or fubftance, tho they do in magnitude s and therefore I have only exhibited figures from three or four foetuses of a different age . / once purpofed to have given reprefentations of the pe- riofteum, cartilages , and bones inje&ed , from exceeding curious preparations in the mufeum of Dr. Nichols, which is indifputably the mofi copious and beft of that kindy that was ever made in this nation , but I was foon deterred from purfuing my defign by the difficulty I found in getting thofe fmall veffels ac- curately and difiinElly drawn. Andy for a like reafony I was prevented from giv- ing draughts of whole skeletonsy finding it was fear cely pofftble to fix an undried b 2 and To the Reader. and well cleaned skeleton of a fetus in a natural pojlure , fo as to take the out line true and beautiful. "The fculptures y which I have procured to bemadefconfefs , come fomewhat fhort of what I defigned and expected. Hho I flatter tnyfelfi as to exaSlnefs , when compared with the heft of any kind yet publijhed, they will not ap- pear inferior to the mofl correct ; becaufe the out lines of mofl of the figures, efpeci- ally thofe of the full grown fetus, were taken in a camera obfcura, and there- fore cannot err greatly from the truth. SINCE the dcfcriptions of adult bones have been frequently publifhed by able hands , I much wonder fome perfon has not attempted to give an. exaSl ac- count of the tune when , and the manner how each bone , and its various parts bi- er eafe and alter from the time of birth to that of its maturity ; becaufe fuch an account is abfolutely neceffary to per fell the ofleological part of anatomy. In my apprehenfion fuch a work would not only be entertaining, but alfo very ufeful both To the Reader. inphyficand furgery. For , by the fewdif- feBions only , which I have made on that account , it appears to me , that the want of it is the foie caufe of fome diflemper s of bones and cartilages being not only im- perfeBly , but falfely defer ibed ; and none more than that peculiar to children , com- monly known by the name of the rickets. The knowledge of this , I am fatisfied \ might be fo far improved by the help of proper diffeBions , as to afford fufficient data, from which to deduce a rational method of cure. Therefore I purpofe y if opportunity offer , of diffe&ing fome more fuch morbid fubjeBs , to give the public a brief account of the rickets, and fuch like diflemper s incident to bony parts , wholly taken from very marifefl pheno- mena, which I conceive to be always vi- ftble within fuch difeafed parts , altho they have not hitherto been obferved , or at leaf deferibed \ fo far as I know , by any author , X11X HU- [I] HUMAN OSTEOGENY. in this or the lafl age, than Ana- tomy. Human difledtions were bymoftof the ancients, efpecially thofe whofe writings are handed down to us, fo rarely ufed, that the knowledge they feem to have had, was chiefly compara- tive, and confequently turn’d to fo little account, that moft of the admirable and curious contrivances of the human ma- chine were entirely unknown to them. But lince diffedtions of all forts have been frequent, both in public and private, and many lovers of and fearchers after Lecture I. O part of phyfic or furgery hath received greater improvements A 2 HumanOsteogeny. natural knowledge have applied them- felves with great care and induflry to anatomical inquifitions ; the improve- ments in the knowledge, not only of the flrudture, but alfo of the ufes of moft parts of the body have been fo confi- derable, as to make what the ancients knew in this fcience appear both infig- nihcant, and often trifling, when com- pared to that of the moderns. And yet on a further examination it may be ea- fily perceived, that great room ftill re- mains for improvements in many, parts of this fcience, and in none more, than in fome parts of Ofteology,efpecially in that I now defign to treat of, which is commonly called OJleogeny. It is furprifing, that the writers* on this fubjedfand efpecially Kerckringius\, who pretends to much greater accura- cy, than any who wrote before him, fhould be fo negligent in their accounts of the rife, progrefs, and manner of ofli- fication in different parts, from its flrft appearance to the time of birth, that ma- ny of its curious and very obvious phce- * Riolanus, EylTonius, Coiterus. t Kerckringii Qfteog. fcetuum. ncmena Lecture I. nomena have been hitherto entirely pafl over by them unoblerved, and not a few others defcribed or reprefented very dif- ferent, from what they naturally appear to be. H e n c e no doubt it is, that the truth has been fo long concealed, and its place fupplied by hypothefes, which had no foundations, but in the imaginations of their ingenious inventors ; altho the dif- ferent times and gradual manner made ufe of by nature to produce the bones of an human body, make her operations fo much more conlpicuous in thole, than any other parts, that by the vilible ef- fects of edification a careful and dili- gent enquirer may reafonably exp e/^v.yi 7. which is not more than the two thoufandth part of the weight of a full grown one, it will be always found to be nearly of the fame fhape as adult ones ufually have, and perfedt bone, with its periojieum co- vering it; and has no more cartilage, or the leaft refemblance of one in or over * Ofteog, feet, cap, il. any * 1 6 H uman Osteogeny. any part of it, in proportion to its fize, than fuch bones are found to have, when they have done growing. In like manner the fame appearance of bone without cartilage, you may al- ways find in thofe of the palate, upper jaw, and nofe, when fome of them are fo fmall, as fcarcely to be diftinguifhed without the help of a glafs, and as thin as an exceeding fine membrane. The teeth likewife are always found to be generated and accreted without e- ver having any cartilage or cartilaginous fubftanceinornearthem, from their firft appearance to the time of their matu- rity. c2rpe T he other fpecies of ofiification, w r hich des of ofi:- firft appears within a cartilage, begins late, and at very diftant times in differ- ent parts. Its fooneft appearance, which is either in the ojja Ilii , or fome of the ver- tebra , is not before th z foetus is more than two months old, and its lateft is notun- til many years after birth. This fpecies requires other preparations befides foetal ones to demonftrate perfectly the man- ner of its production ; for tho in fmall fpines, fuch as plate i v.Jig, 1 2, a grada- *7 Lecture I. tion of offtficationfrom a point to a con- ftderable body, is always to be feen; by which many, feemingly with good rea- fon, have been induced to conclude, that allfuch like offtflcations begin in a point, and round that gradually accrete until the part arrives at maturity : yet an exa- mination of thole parts, which do not begin to oflify until a few weeks before birth, and have not their ofliffcations -nearnniihed until fome years after, fhew the bony particles to be very frequently depoftted in various parts of the cartilage in diftindt clufters irregularly lituated; all which afterwards perfectly unite. Thos e cartilages of almoft full grown foetuses , in which are to be found either tendencies to ohify, of ofliffcations juft beginning, plainly fhew that not one bony particle is to be perceived, or felt, before there is a viftble influx into the cartilages of a fluid different from what ufed to flow through them : as in the fedtions of oftifying epiphyfes, plate vi, f. 9, i o. you fee both in that which has no viftble bony particles, and others w^hich have a few, many of thofeveflels, which while the part continued totally cartila- C ginous H UM AN O ST EO G EN Y. ginous without a tendency to oftify, were too fine to be diftinguifhed or perceived by the greateft magnifying microfcopes, and confequently too fmall to admit the red globules of blood to flow freely thro them, appear to have been, by a more than ufual afflux of fluid into them, fo much dilated, as to receive a quanti- ty of red globules, fufflcient to make fome part of them diftin< 5 tly viflble to the naked eye, and to caufe in and near the place, where theofliflcation is to be- gin, and round it, always when juft be- gun to be apparent, and frequently af- ter it is confiderably increafed, fig. 1 3. the appearance of an inflammation. The flrft fmall corpufcles of bone, which become viflble, are always in that part of the cartilage, which has the great- eft quantity of red fluid appearing in it, and are not always placed clofe toge- ther, but often at fmall diftances from each other. In fome of theveftels, which are much dilated and appear full of blood, or a fluid very ftmilar to it, there are often to be felt, with the point of a knife, hard gritty particles, which I take to be bony. In Lecture I. In fome epiphyfes , fuch as you (opiate vi .fig. 8 . cccc.fig. ii. fig. 12. there are often three or more very conflderable veffels going to and penetrating the ofli- Acations, within which veflels, andfuch like, at their ends, near the offiflcati- on, you will rarely mifs feeling, by the point of a knife, bony particles. And if the cartilage be flit into thin pieces, and dried flat between two plane gla fles, there are often to be diitinguiflied by the nak- ed eye, tho oftener by the help of a mi- crofcope, in thefe dilated velfels, what to me feem to have the true appearance of bony particles. In the little red Ipecks, which fometimes appear with one or more fmall veffels ending in them, on fedtions of foetal epiphyfes , plate vi. fig. 11. a a, bony particles are generally to be felt, and fometimes even feen. Thus much is evident, from faetahpvt- parations, of the manner in which thefo fort of bones begin,, and continue until birth to be generated; but on examina- tion of the lame parts in children, three or four years after birth, the X\k.z pheno- mena will be much more apparent, be- caufe the veffels, which enter the oflify ing C 2 parts. 20 HumanOsteogen Y. parts, areconfiderably larger, and confe- quently their contents more eafily difco- vered. Moreover, you will feldom, if ever, fail of finding in the large epiphyfes , par- ticularly thofeat the bottom of the thigh bones of children between three and fix years of age, confiderable vefiels, con- taining bony particles and a red fluid. And at the fame time you may obferve the progrefs of thefe ofiifications to be after birth lefs uniform, and not fo clofe together, as they are always found to be in foetuses , but are irregularly depofited round, and joined to that part, which firft began to ofiify. In various parts alfo of the cartilage, which you find be- tween the ofiifications, there are fre- quently to be feen dilated vefiels partly filled with bony matter. M o s t of this fort of bones are very fpongy and cellular ; and have the fize and figure of their cells, which are ge- nerally final!, regulated by the medul- lary and veficular fub fiances contained within them : and their external and more folid parts are compofed of bony threads, which are difpofed according totheihape of the part, in the fame man- ner Lecture I. ner as has been obferved of the other fpecies of oftification. Very loon after the vettebrce . , and fuchlike parts, which do not remain ve- ry long after conception wholly cartila- ginous, begin to oilify, their increafe is fo manifeftlymore from the accretion of the bones, than the cartilages, that long before thofe bones arrive at half the ftze of adult ones, the cartilaginous fubftances decreafe, and gradually, as the bones grow, become fo thin, as to feem to be entirely deftroyed, except next thejoints, where cartilages remain for the benefit of the articulations, and continue in healthy fubjedts to grow, and receive nutrition, as long as any other part of the body. How little foetal bones are depend- ent on the cartilages, in which they are generated, may be made apparent, if any of them, while the cartilages en- tirely or almoft furround the bone, be kept a fufficient time in water; for then, as you fee, plate iv.fig. i o. a. b. plate vL fig. 1 7. a. b. on only flitting the carti- lage, the bone will, as foon as the large veiTels that enter its fubftance are di- 22 H uman Osteogeny. vided,flip as eafily, if not cafier, from it, than an acorn does out of its cup. And by the fmoothnefsand polifh of the parts of both cartilage and bone, which were in contact, itisverymanifeft, there could be no intermixture of their particles, or continuation of the fibres of one fub- ftance to thofe of the other. The cartilage alfo, which joins at birth part of the os occipitis to the hinder part of the petrofum , juft beyond the place where the mammillary apophyfs is after- wards form’d, demonftrates, that there is no conjunction or union of the fibres of thefe two fubftances, plate i. fig. 12. k. Jig.i^.k.platen.fig.c). /LForasfoonasthe pericranium and dura mater are remov- ed, the cartilage, by gently pulling, will feparate or come from the bone with- out the leaft laceration of its fibres. The material phenomena of the two fpecies of oftifications having been alrea- dy fhewn and truly defcribed ; I come now to examine, whether by them it is not demonftrable, that the notion of all or any bones being originally cartilagmous x is not without foundation in nature , in or- der to inquire, how near the confidera- Lecture I. 2 tionofthefe phenomena will bring us to the knowledge of the true manner and caufe of bony productions. It is at prefent, if I am not very much miftaken, almoft univerfally al- lowed, that all thofe juices, which are the productive caufes of the accretions of each part of an animal body, are origi- nally deduced from the mafs of blood, and formed by different coalitions of va- rious combined particles contained in it; which particles, by the power of circu- lation and attraction, are fecreted, and forced into veffels capable, in a natural ftate,of receiving only fuch, and through them conveyed to the parts defigned to be augmented. And it is as univerfally denied, that the juice, which is the pri- mary caufe of the productions and ac- cretions of the bones, is capable of gene- rating perfect bony fubftances, without firft forming a cartilaginous one. Bu t by what has been related of the beginning and progrefs ofbony producti- ons in different parts of foetal bodies, it appears to ocular demonftration, that fome bones begin and continue to in- creafe until |hey arrive at maturity, with- out H umanOsteogeny. out the leaf! appearance of cartilage in or round them ; and that others, though they are generated within cartilages, have not in or about them a quantity of car- tilaginous fubftance exifting, as long as they continue to grow, fufficient to af- ford matter for their increafe in bulk or folidity; confequently, if any part of a bone be produced by a tranfmutation of a cartilage, nature muff ufe various me- thods at different times to generate and accrete the fame bone. But as nothing is more certain, than that nature is never at unneceffary trou- ble in any of her performances, and is always fo conformable to herfelf, as ever to operate uniformly in the mofl eafy and frmple manner, fhe cannot reafon- ably be fuppofed to produce limilarfub- ftancesinthe fame body, and at the fame time, from different origins, and in dif- ferent manners. A n d what you have feen of bones flipping out of the cartilaginous cavities, in which they were generated and con- tained, affords a plain autoptical demon- ftration of the entire independence of thofe two fubftances on one another, as can Lecture I. 25 tan be had, or reafonably exfpetfted of things of this nature. And befides, as a further confidera- tion, if you examine, ever fo accurately, oftiiications in any aged fubjefts, you’ll never find any particles or fibres in a middle ftate between bone and carti- lage; which furely would at fome time or other happen to be apparent, if the fofter fubftance was gradually tranfmut- ed into the harder. That the formation of all bony The P ro- fubftances is immediately caufed by fe- bones not creted fluids, may be fufficiently prov- ed by the phenomena , which have been fhewn already to be always ex- iftent in cartilaginous parts, juft before and after oftifications within them be- come viftble. For by the remarkable dilatations of fome veffels within the car- tilages you faw, plate vi. jig. 9, 10, 1 1, 1 2. and the red colour of the fluid con- tained within thofe dilated veffels, it plainly appears, that nature never fails to fupply all cartilaginous parts, both a little before and during the time offifi- cations are forming within them, with a quantity of a fluid very different from D what 2 6 Human Osteogeny. what at any other time is naturally to be feen in any part of them. And the ap- pearance of bony particles only in that fluid, feems to prove that neither the folid nor fluid parts of cartilaginous fubftances are in the leaft concerned in bony productions. That the Blood is capable at all times of life of generating and fufpend- ing a fubftance perfectly analogous to the cretaceous parts of bones, is demon- ftrable by the chemical analyfls of thofe cretaceous fubftances, which are fre- quently found to be feparated together with the urine from the blood; as like- wife thofe fubftances commonly called chalk-fiones , which are often generat- ed in various parts of gouty bodies. T hefe chalk-Jlones , tho they have been fup- pofed to be caufed by an induration of membranous and tendinous fubftances, will appear to be produced only by the coalitions of cretaceous particles contain- ed and fufpended in the blood, or a fluid feparated from it, by only opening a tu- mifled part, in which they are about to be generated, and letting out the fluid contained within it ; which is a never fail- ing 2 7 Lecture I. ing method ufed by Tome people to pre- vent the production or increafe of thole liibftances. What has been now obferved con- cerning the different manners of bony productions, and the phenomena which are vilible during the progrels of ofii- lications within cartilaginous parts, are fully fufficient to prove all bony parti- cles to be originally contained and fuf- pended in the blood, or a fluid fecreted from it, which may be called the ojfi- fying juice , much in the fame manner as ftony and faline particles are very fre- quently found in fome of the mofttran- Iparent fpring waters. I must not here be underftood to mean fuch bony particles as I defcribed to be vilible, but the fmalleft particles of fuch like matter, by the cohefion of a number of which the apparent ones are compofed, and therefore theyfhould ra- ther have been called bony corpufcles. And by the fam tphcenomena itfeems to be demonftrable, that the oflify- ing juices are fecreted and conveyed to the parts deligned to be by them ge- nerated or accreted, thro veffels peculi- ; D 2 arly H UMAnOsTEOGE NY. arly formed for that purpofe ; and that they are by the force of the circulation pufhed on to the beginning of theveflels prepared to receive refluent juices, which, as appears by the obftru&ion in fome meafureof part of the circulating fluids, in a place beginning to oflify, being fo fmall, as to permit only the finer and more aqueous parts of this juice to enter and pafs forward, the groffer confe- quently mu ft be left behind; by which means their particles approaching nearer each other, have their attractive force fo increafed, as fufticiently to draw one another into a cohefion ftrong enough to form fmall hard corpufcles, much in the fame manner as the particles of fait at- tract one another, and unite, fo foon as a fuflicient quantity of the water, in which they were fufpended, is evapo- rated. And as it is well known by Ruycjh\ experiments, that the blood is capable of forming fine membranes, it feems to be much more confident with the ap- pearances of nature, to fuppofe thofe membranous parts of a bone, which acft as a gluten to keep thefe particles and Lecture I. 29 fibres together, if there beany fuch, that do not arife from the coats of its veflels, to be produced by a cohefion round the cretaceous particles of apart of the fluid, in which they were generated or contain- ed, than to reckon them parts of the car- tilage, in which the bone firft becomes vifible; becaufe it is very plain byinlpe- cftion, that as the bony particles are de- poiited within dilated veflels, the coats of thofe veflels prevent the cartilaginous fubftances ever coming into contact with moft of thofe particles. Let us now examine the objections, objeftions which may be raifed to what has been ad- vanced, elpecially the chief arguments made ufe of to fupport the vulgarly re- ceived notion of the caufe of oflification ; ' the moft material of which is drawn from the fuppofed change of cartilages into bones, which often preternaturally happens, in both young and ancient peo- ple, and is frequently mentioned, as an indifputable proof of the natural tenden- cy of that fubftance to become bone. But the frequent oflifications of mufcular, tendinous, and membranous fubflances, as well as cartilaginous, fliew no 3 o H uman Osteogen r. no more peculiar property to be in the cartilaginous fubftance to turn bone, than in any other. On examination of any of thefe preternatural productions, whether they be in mufcular, tendinous, membranous, or cartilaginous parts, and whether they feem to be bony incruftati- ons, as they moft frequently do, or other- wife ; the bulk of the part is never lef- fen’d, where the oflification is, but always appears fufficiently augmented to prove, paft all difpute, that there had been a quantity of matter, proportionable to its increafe or alteration, depofited in or up- on it : which demonftrates even thefe preternatural offifications not to be pro- duced, as has been fuppofed, by an ex- preftion, or an exhalation of the more li- quid part of the fubftance about to offify, in order to make way for its earthy and more folid particles to approach near e- nough together to acquire the hardnefs, and caufethe appearance of a bony fub- ftance ; becaufe if it had been in that man- ner generated, the bulk of die part muft neceffarily, by offifying, have been great- ly diminifhed, the bulk and weight of all animal fubftances, except bone, depend- Lecture I. ing indifputably much more on their fluid, than folid parts. The pretended reduction of bones into cartilages by fteeping them in vine- gar, which caufeswhat remains of them to become flexible, and while wet very foft, has been urged as a proof tofupport the common opinion of bones being ori- ginally cartilaginous. But this expe- riment is fo far from fhewing that the bony fubftance is liable to be changed, or reduced to a cartilaginous one, that, on the contrary, it proves all thofe cre- taceous parts to be infirely taken away, which the vinegar could penetrate to. For what remains of a bone after it has been fome time in vinegar, is only its membranous part, which the acid can- not operate on, as it does on the cre- taceous, which it foon diflolves by fer- mentation. By the many experiments of this kind, which I have made on foetal bones, I find thofe which are moft folid lofe, by ly- ing a fuflicient time in vinegar (which was often changed, becaufe the bones deftroyed its acidity) rather more than two thirds of their weight. And the moft 02 HumanOsteogeny. moft fpongy, which are the bodies of the vertebra^ lofe very near four fifths ; fo that the great lofs of weight in this operation fhews, that the effential part of a bone is deftroyed, and not chang- ed, as was fuppofed. And the mem- branous fubftance, which is left be- hind, is fo far from having the refem- blance of a cartilaginous one, that it is always very fpongy, whereas a per- fect uniform folidity is a conflant and never failing property of all true carti- lages. But tho this experiment does not prove what was deiigned by it, yet it ferves to confirm, what I have as yet only hinted at, that bony fibres and par- ticles are furrounded and kept together by membranes ; for if a foetal rib, or a- ny fuch like bone, be lacerated accord- ing to the courfe of its fibres, after it has been fteeped in the manner juft men- tioned, and then dried, you’ll fee many bony particles, which were by the acid, but in part diffolved, to be contained within membranes, out of which you may then eafily fhake them. Since Lecture L Since the effeCts of a chemical pro- cels have been mentioned (tho, as I have fhewn, to little purpofe) as an argument to prove all bones to be originally cartila- ginous, it will not be improper for me to oblerve, that I have found by calcination, which is another chemical procels, the mod: folidpart of full grown foetal bones, to contain, of terreftrial parts, not to be deftroyed by the fire, fix out of eleven ; which is only one part of eleven lefs in quantity of earth than I found to be con- tained in the mod: folid parts of adult bones ; but of fuch like earth in foetal cartilages, I could not find, by the fame method, fo much as one part of an hun- dred. I will not from hence attempt to draw anyconfequences, becaufe I am fenfiblethey would unavoidably be lia- ble to feme objections ; but I’ll leave it to your confideration, whether it is ei- ther pofiible or probable, thata fubdiance, which is compofed of fo great a quanti- ty of earth, or fix’d matter, fhould be generated by the induration of one which contains fo very little. B y way of objection it will, I do not doubt, be ask’d, what becomes of thofe E carti- 34- Human Osteogeny. cartilages in which bones are generated \ if they be not by induration , compa£lion y or fame other method \ tranftnuted into bo- ny fubjlances f Tho to fome it may feem a difficult task to give a fatisfadtory anfwer to this queAion ; yet to thofe, who with proper care examine the cartilaginous parts of different aged foetuses and children, dur- ing the gradual progrefs of the ofliflca- tions, which are generated within them, it will plainly appear, that thofe carti- lages, by the great influx of variousfluids into them, and the continual increafe of the bony fubftances, are fo extended, or fpread out, as to lofe totally all the pro- perties of cartilages ; and what remains of them becomes inmoA parts a mem- brane fo exceeding thin, as to be altoge- ther imperceptible : Therefore I think thofe cartilages may truly be faid to be entirely deftroyed. It has been already obferved, thatal- moA immediately after fuch of thefe fpe- cies of bones, which are firA produced after conception, begin to grow, they increafe much faAer than the cartila- ges within which they are contain’d ; con- Lecture I. eonfequently they muft caufe thole car- tilages, by the conftant increaflng prefr fure made on them in their growth, to be gradually extended, and at the fame time may hinder the nutritious matter from flowing freely into them, and there- by make themtodecreafe continually in the lame manner, as all other parts of an animal are frequently found to do, fo foon as the flux of nutritious juices to them are, by prefliire, or any other means what- loever, either impeded or obftru&ed. It is certain, by only drying foetal cartilages in the open air, they will lofe more than four parts in five of their weight: therefore how thofe fubftances, by extenfion, and the exhalation or ex- preffion of their fluid parts, may be re- duced to fuch a thinnefs, as to become altogether invifible, cannot, I think, be difficult to conceive. Those parts which never begin to oflify before eight months after conce- ption, and are not totally offified until many years after birth, fuch as the epi~ phyfes of the os fe?noris and tibice^ efpeci- ally when they are much inlarged by five or fix years growth, always exhibit, if they E 2 are HumanOsteogeny. are Hit while very freib, fo beautiful a view of the manner in which this fpecies of oftification increafes, and at the fame time of the decreafe of the cartilaginous fubftance, that contains it, as cannot by words be defcribed, or, without feeing, truly conceived : for by fuch preparati- ons fome of the cartilaginous fubftance plainly appears to be fo far from being tranfmuted into a harder one, that a fmall part of it may be perceived, in fome of the fpaces between the irregular bony fhootingsof thefe parts, to be fo extend- ed by the influx of a reddifh thick fluid into it, as, together with that fluid, to have the appearance of a very foft fub- ftance, fo much refembling a medulla- ry one, as makes me imagine it to be the marrow, or what generates it, con- tain'd in a membranous bag, form'd by the extenfton of the cartilage. It may be further queried, why any bone or bony fubftance is generated with- in a cartilage , if that fubfla? / ice in no de- gree affords matter to caufe its production or accretion f The anfwer to this queftion will be obvious from the account you will here- after Lecture!. 37 after have, of the time, when each bony part of a foetal body is generated. For by that it will appear, nature never produces, in any part of the body, a bony fub- ftance, as long as a lefs hard one of equal magnitude can, with like benefit to the creature, fupply its place. Therefore, in order to keep a proper fymmetry and proportion, at all times, in every part of a foetal body, it was abfolutely neceflary thofe places, in which bones were afterwards to be ge- nerated, fhould be filled with a cartila- ginous fubftance, the folidity and hard- nefi of which being nearer to that of bones, than any other in an animal, is confequently the moft proper to fupply their places. Thus you will find, the Ipine, that is chiefly defigned to fupport a weight, which for feveral months after conception is fo inconfiderable, as not to require a fubftance fo hard, as a bony one, to perform that fervice, continues for a veryconfiderable time, either alto- gether, or in part cartilaginous, and does not become perfectly bone in every part, until after birth 5 at a time when a fcfter 9 Human Osteogeny. fofterfubftance would apparendy be in- capable of performing the natural fun- ctions of thofe bones. The cartilage alfo in thefe parts ferve, as has been already mentioned, as a bed for the bony fibres to fhoot fe- cure from any impediment, or injury, they might be liable to receive from the motion of the foetus , or external prefliire. As for the fame purpofe nature provides in many parts callus s after fraCtures, as well as to fix the ends of fome bones to- gether, before the bony particles begin to be depofited, becaufe, without fuch a fubftance, thofe particles would con- tinually be fubjeCt to have their fixati- ons varied, not only by the motions of the part, but alfo by the conftant pref- fures arifing from the different actions of the circumjacent mufcles ; and confe- quently their union would be liable to be frequently impeded, and fometimes intirely prevented. The confideration likewifeof theufe of thofe bones, which are form’d be- tween membranes, help us to the rea- fon, why they are never furrounded by cartilaginous fubftances, and are Lecture I. the firft generated and perfected. For we find moft of thele bones, even when their ofilfications are far advanced, to be either fo exceeding thin, or fo very fmall and fiender, that a cartilaginous fub- fiance of their fize could not have much more folidity, than the membranes, be- tween which thole bones are produced; and while the fostush(o fmall,the moti- ons of it cannot be fufficient in any degree to impede the natural progrefs of the olfi- fications. As for example, we find the cla- vicles and ribs to be ofiified, even when they arefo fmall, that it is demonftrable, from the confideration of the ufe they are defignedfor(whichisto keep the thorax always fufficiently dilated, and thereby fecure the motions of the heart from all manner of impediments and obftrudfi- ons, they might be liable to from the collapfing of the fides of the thorax by preflure) that no other animal lubflance but bone of their fize cou’d be fufficient to perform that office. Hence, to conclude, you lee by a careful and accurate examination of the various appearances of nature in the bony parts of fcetal and young bodies. Human Osteogeny. in what manner it will always be ma- nifeft to diligent inquirers, that there is not one fingle phenomenon tofupport the notion of bones being nothing but in- durated cartilages, or that they are pro- duced only by a tranfmutation of a car- tilaginous fubftance. And that there are a fufficient variety of phce?iomena to af- ford autoptical demonftrations, that the blood, or a fluid fecreted from it, is ca- pable of producing bony fubftances, without firfl: forming cartilaginous ones. It likewife appears, that the moft material arguments, drawn either from the natural or preternatural effects of oflification, which have been ufed to fupport the common hypothefis, may, with much more reafbn, be ufed to o- verturnit,andto prove that all bony pro- ductions, whether natural or preterna- tural, are caufed intirely by the appo- fition of cretaceous matter, fufpended and brought in a fluid to the oflifying part, and there depoflted. HUMAN HUMAN OSTEOGENY. Lecture II. ccording to what I propos- ed, I am now to give an exad: defcription of the apparent dif- ference, there is naturally to be perceived, between the parts of afrefh or undried skeleton of a full grown fee - ins, and thofe of an adult ; and alfo to mention, at what time, and in what man- ner, each part increafes and varies from its formation to the time of birth. I n performing this part of my un- dertaking, I Shall, according to the moffc general cuftomof anatomifls, divide the skeleton into head, trunck, and extremi- ties; and I propofe to make ufe of fuch names only, under which the adult bones F have ^2 HumanOsteogeny. have been commonly defcribed, altho I fhall often be obliged to give the defcri- ptions of two or more very diftindt bones under one name ; becaufe a fcetal skele- ton is divifible into many more parts, than an adult. I begin with the bones of the head, which are divided into two general parts, thole which form the cranium or skull, and thofe which make the greateff part of the face. The era- T h e bones of the skulls of foetuses are not joined by futures, but are kept together chiefly by the membranes that cover both their iides, each of which membranes is diftinguifhed by a parti- cular name; the internal one being call- ed the dura mater , and the external the pericranium. Some have reckoned thefe two membranes to be diftindf from the periofieum of the bones they cover ; but, as the membrane, that they call th epe- riojleum , is no eafier feparable from ei- ther of thefe membranes, than the inner part of the periofieum of the fhin bone or thigh, is from the external ; and as the periofteu?n of moft parts may be divided intofo many diftindt membranes as thefe two, Lecture II. two, I therefore am convinced, that nei- ther the dura mater nor pericranium is any thing more than a common peri - ojleum. Before the fuperior part of the cra- nium becomes bony, the dura mater and pericranium are ftrongly attach’d toge- ther, and fo continue, until by the growth and fpreading of the bones, that are generated between them, they become gradually feparated, which does not hap- pen wholly until many months, and in fome fubje&s feveral years after birth. For, on the forehead, between the tops of the frontal bones and part of the an- terior and fuperior edges of the fyncipi- tals r and on the occiput , above the upper angle of the broad or triangular part of the occipital bone and part of the pofte- rior edges of the fyncipitals , there are in moft foetuses two openings ; the one called the frontal fontanella , pi. i.fig. x . d the other the occipital. Nature’s defignin caufing the fron- tal opening always to remain until after birth, and alfb the loofe connexions of the bones of this part of the head to continue as long, was no doubt to permit by pref- F z fure s HumanOsteogeny. fure, at the time of delivery, a confider- able diminution of the skull’s circum- ference, in order to facilitate birth. The reafon, why but little of the occipital fontanella continues until birth, is, becaufe y as the great and accu- rate anatomift Morgagni * rightly ob- lerves, there is much more danger from preffmg the cerebellum than the cere- brum; therefore, as far as wasneceffary, nature has provided againft it, by mak- ing this opening at that time fo fmall. The fuperior and external part of the skull, at birth, is convex and very fmooth, plate i. fig. i. but, its inferior and external part has many inequalities to afford convenient places for the rife and infertionsof mufcles, which are not near fo large, in proportion to the fizeof the skull, or fo numerous, as in adults, h - 2 - Its internal fuperior part is concave, and almoft as fmooth as the external. For the bones being loofe, fo eafily give way to any force, that the blood-veffels cannot prefs fufficientlyonthemtocaufe fuch deep imprefiions or furrows, as * Adverfar. Anat. ii. Animad. 3 z. 45 Lecture II. are generally formed foon after they be- come fix’d by their futures to each o- ther. The bafis, or inferior internal part, does not feem, while covered by the du- ra mater, to differ much from an adult. The greateft part of thefe bones do not, like adult ones, confift of two ta- bles and a diploe , or meditullium , but almoft every part of them is thin, and compofed only of a few lamince with fcarcely any cellular fubftance between them. The skulls of all aged foetuses are much larger, in proportion to the fize of the trunck and limbs, thanthe skulls of adults : and in very fmall foetuses the fonta?tellce are both confiderably bigger in propor- tion to the fize of the head, than at birth, efpecially the frontal one, which is con- tinued quite down to the nofe; and none of the bones are fufficiendy formed to touch one another fcarcely in any part, and confequently, have openings or va- cancies between them, moft of which begin to difappear about fix months af- ter conception. A f u l l grown foetal cranium is di- yifible into more than twice as many parts H uman Osteogeny. parts as an adult one: for the os frontis is always divided into two diftin 57 , Lecture II. put, by all which bones their external edges are furrounded, fig. 2. n.n. l.L fig. 9. n. n. r. r. The fourth bone feems to me to be the hinder part of the os fiphenotdes ; be- caufe, before the oflifications begin, the place of this, and the body of the fiphenoide bone is always filled with one cartilage,, in which the edifications constantly be- gin in various points at fome diftancefrom each other, which in time are united in one ; but, as it has been ufually reckon- ed a part of the occiput , I fhall confider it as fuch. It is often called the cunei- form procefs of the occipital bone. Ex- ternally it does not differ greatly from an adult, fig. 2. q. except at its condy - loide procefies, which are much fmaller, The cavity on its interior fide, in which is lodg’d the medulla oblongata , is not near fo deep, at birth as afterwards, f. 9. q. It is connected at the condyloide pro- ceffes, by cartilages, to the firft and fe- cond bone of the occiput , fig. 2. r.r. and its anterior fide joins the cartilage at the hinder part of the body of the os fphe- noideso H These Hu man Osteogeny. These four parts of the occiput joint- ly form the great foramen , thro which the medulla oblongata pafles out of the skull, fig. 2. t. Between two and three months af- ter conception, the places of the firft and fecond occipital bones are entirely filled with cartilages, but the fourth has a fmall ofiification in it. About three months theofiifications in the firft and fecond parts begin pret- ty near the middle of each, and increafe gradually in the fame manner, until each part becomes entirely bone; which generally happens in the cuneiform pro- cefs between four and five months ; but in the other parts, tho the ofiifications leem almoft perfected at fix months, yet they are not wholly compleated until af- ter birth. Each of the temporal bones at the time of birth is compos’d of three parts, befidesthe fmall bones of the ear, which, as has been mentioned, are diftinguifh- ed by particular names. The fuperior one, called os fquamo- fum , is a thin, broad, and almoft femfi* circular bone, externally finooth, and a little Lecture II. , little convex, pi. i.fig. i.hjig. 1 2. A It has a confiderable procefs, call'd zygomatic , that rifes at the inferior part of the bone juft above the annulus , jig. 1. i.jig. 12 ,i. from whence it ftretches forward to the procefs of the os malce of the fame name. It is much ftenderer in foetuses than in adults, and much lefs curved. Under the root of this procefs there is a fhallow oblong ca- vity, lined with a very thin cartilage, f which in adults is much deeper, for the reception of the condyloide procefs of the under jaw. The tubercle fituatedjuft before this cavity, on which the under jaw plays, when it is by the external pte- rygoide mufcles drawn forward out of the cavity, is now fcarcely perceivable. Between the hinder and lower part of the cavity, and the annular bone, there is a fiffure, thro which pafies that branch of the fifth pair of nerves, which, with- in the tympanum , is called chorda tympa- nic jig. 2. h. The internal part of this bone is a lit- tle concave,^. 13. A and its fuperior part pretty fmooth. Near its bottom there is a fmall ridge, which runs crofs part of the bone, and by which the os H 2 petrefum 5 9 6 o HumanOsteogeny. petrofum is join’d to it, much in the fame manner, as epiphyfes arejoin’d to the bones they belong to, fig. 13 .i. i. Juft above this ridge there is a fmall hole, which is not to be found in adults, /. The part below this ridge is rough, and in its hinder part there are fmall cancelli ; it forms the exterior and upper fide of the cavity, in which the fmall bones of the ear are com tained, plate ii .fig. 8. m. T he femicircular edge of this bone does not lap over the inferior fide of the os pa- rietale now, as it does foon after birth. At its anterior fide it is fpread a lit- tle over the temporal procefs of the os fphenoides , and its hinder fide alfo lapso- ver the os petrofum , above the place, where afterwards grows the mafioide procefs. The inferior part of the temporal bone is called petrofum , from its general hardnefs in adults.. Even at the time of birth many parts of it are harder than moftof the other bones; althoitsfolidity and hardnefs gradually increafe, until it arrives at maturity, when it becomes the hardeft part of the body, except the enamel of the teetL A Os petro- ium. Lecture II. A great part of the petrofum is not form’d at birth, particularly the large and thick apophyfis , which is called mamilla - ris or mafioidceus , in the place of which, there is not fo much as a cartilage; but the part, from which it afterwards fhoots, flants from the annulus upward to the cartilage, which now fills up the fpace between this bone and the occiput , pL L jig. 2. l.l. jig. 1 2. L The ftyloide epiphyfis of this bone, jig. 14. a. which is fituated juft behind the pofterior part of the annulus near its hinder end, and juft before the hole, which is called the aquceduElus Fallopii, b, is, at birth, and a long time afterwards, wholly cartilaginous. In foetuses it al- ways lies almoft dole to the skull, croft the meatus auditorius externus , with its end or point towards the fauces, in which pofition it continues fome months after birth. I once found both thefe epiphyfes thus fituated in a child turn’d of four years of age, which could not lpeakany word diftin&ly. From whence I con- jectured, their pofttions might be the chief, if not foie caufe of the great im- pediment 6 2 Human Osteogeny. pediment the child had in its fpeech ; becaufe as thefe epiphyfes are of a conft- flderable length, the diftances of the o- rigins of thofe mufcles, which rife in them, and are inferted into the tongue, muff be conftderably lefs, and confequently, the force of their actions much varied, when they lie almoft flat in the manner I juft mention'd, than when they are ft- tuated almoft at right angles with the petrofum , which are the ufual or natural lituations of them under four years of age, as well as at maturity. The w petrofum has four fldes, two internal, which are within the cranium , and two external, which are without it. O n the external fldes there are feve- ral remarkable perforations, befldes the large paflagetothe ear, which is perfect- ly covered by the membra 7 / ia tympanic andfurroundedby the bony ring ,fg. i 2. n . 0. 0. 0. That hole which is on the fu- perior flde, juft behind the root of the fiyloide epiphyfis , which is the paflage of the portioduraoi the auditory nerve, and isufually called aquceduBus Fallopii, is of an irregular form, and in proportion t q V Lecture II. the fize of the foetus, larger than in an adult, fig. 1 4. b. The large hole on the inferior exter- nal ftde, which firftafcendsdire&ly, and then runs forward, and penetrates at the end of the bone (not into the cranium , thro which pafs the internal carotide ar- tery, and the beginning of the inter cofial nerve) is generally rather lefs than in a- dults,y£g\ 2. v.w.fig. 14. d.e. The in- ferior external fide has alfo feveral fmall cavities in it, with many fmall perfora- tions, and often a flender fharp procefs, fig. 1 4. c. which is generally broke in cleaning the bone. The fuperior fide, beyond the annu- lar bone, where the mafioide procefs af- terwards grows, is pretty fmooth, and has many fmall perforations,^. 2 . 1 . 1 . A t the anterior end of this bone, juft above the paffage of the carotide artery, there is the opening of an irregular fhap- ed tube, which runs backward into the cavity of the ear, known by the name of tuba Eufiachiana , fo called from the greateft and moft accurate anatomift of his time, Eufiachius y its firft obferver, It opens into the tympanum^ juft under that part 64 Human Osteogeny. part of the annulus , which is next the fmall procefs of the fphenoides , fig. 2. at. Its end next the fauces is cartilaginous. The internal fidesof this bone, which are within the skull, are in fhape very different from adults, fig. 13. The fu- perior fide is not divided from the infe- rior by a fharp ridge, which in adults is continued from one end of the bone to the other, but by a thick round one, which about the middle ends at the great hole, that runs under the fuperior femi- circular canal, fig. n. from which ano- ther thick ridge runs back, and, as itap- proachesthe end of the bone, grows pret- ty fharp, p. O n thefe fides there are two large per- forations, the anterior and inferior of which is called meatus auditorius inter- ? 7 us , fig. 13.0. which foon divides into two, one of which is the beginning of the aquceduElus Fallopii , the other foon ends in feveral dudls, which afford paf- lages to the portio mollis of the feventh pair of nerves into the vefiibulum and cochlea \ thro it alfo an artery paffes. This meatus is larger, in proportion to the £ ze of the bone, than in adults. Above Lecture II. Above and behind the meatus inter - nus is a larger hole », which, thoat birth is fo conftderable, in adults is often fcarce- ly viftble, and never half as big. It has over it a large round ridge, which, as has been mentioned, is the upper femicircu- lar canal m. From the bottom of this ridge, or a little lower, there is another fomewhatlefs, within which is the infe- rior femicircular canal, and under that a' fmall perforation. O n the upper ftde of the bone there is a long hollow or f ulcus , in which are lometimes a few fmall holes, obferved by V alfalva *, but never to be leen in adults. About the middle of this fulcus there is a hole larger than the reft r, and a little more forward than that, juft be- low the fulcus , there is the opening of the canalis Fallopii , f The cavity on the inferior fide, in which the finus lateralis dune matris ends, is not near fo deep or large as in a- dults q. Under the inferior femicircular canal there is alfo a hollow which is not to be found, when the bone is full grown. * De Aure. I The 66 Hu m an Osteogeny. The rnoft hinder part of the petro- fum is not perfectly form’d at birth, but has about it a cartilage, by which it is join’d to part of the os par iet ale and oc- ciputs , , fig. I 2. k. fig. 13.^. At two months after conception the os fiquamofium is not begun to be form’d, but the petrofium is altogether cartilagi- nous, and with proper care the fiyloide epiphyfis may then be found. About three months the fiquamofium is partly generated, a nd its zygomatic pro- cefs is fo much form’d, as to reach al- moft the fame named procefs of the os males, plate ii .fig. 6. But the petrofium is yet wholly cartilaginous. At four months the fiquamofium is a little increafed, fig. 2. a. fig. 5. and the os petrefiumis begun to ofiify, fig. 4. But thefhapeof it at that time is very differ- ent from what it has at birth, fig. 2 .b.b. fig- 3 - About five months the fiquamofium is fo enlarged, that it touches the tempo- ral procefs of the fiphemide bone, and al- moff reaches the parietal , and its zygo- matic procefs is entirely form’d. The fetrofiumhas thenanoffification near the foramen. 6i Lecture II. foramen rotundum , and alfo one, and fometimes two others, in the hinder part of it, near the canales femicirculares. At fix months the different offifica- tions in the petrofum are united, plate ii„ fg. i. and the beginning of the tubaEu- flachiana is form’d a , as alfo a fmall part of the carotide dud:; but the hinderpart of the bone is yet mofdy cartilaginous A At feven months the grea tell part of the petrofum is generated and offified, except at its poflerior end, there is a car- tilage,^. 9. k. which gradually leflens, but is not totally gone until after birth ; and at the hinder end of the inferior and external edge of the fquamofum there re- mains a thin cartilage almoft as long. Within the os petrofum are contain- ed the little bones and other parts of the organs of hearing, to which there are two paffages already taken notice of ; but th z annulus ^ or bony ring, which fur- rounds the great aperture to the tympa- num , remains to be defcribed. T h o this bone has the name of an- Amuiius. nulusy or circulus , its two ends do not meet, but are join’d at a fmall diftance from each other to the os fq I 2 the namofum , HumanOsteogen.y. the anterior end generally clofe to the root of the zygomatic prccefs, and fome- times a little beyond it 5 and the pofteri- or at the end of the inferior edge of the fquamofum , where it joins the petrofum , plate i. fig. 2. y. z. It is a narrow bone, externally a little convex, and internal- ly has a fulcus or groove in it, to the edges of which is fixt the membrana tym- panic plate ii. fig. 1 2. A t birth it is join’d by membranes to the edges of the aperture it furrounds. At its anterior end, on the internal ridge, there is aprocefs,which touches the neck of the malleus , and is by a membrane join’d to it, fig. 8 . n. Both its ends I have found in fome fubjects perfectly united to the fquamofiumc in others only the anterior one, and fometimes neither. Before three months after conce- ption this bone is form’d, and then is al- mofl as fine as a hair ; and between three and four months it is very elaftic, and may, by freeing the ends of it, be ilipt out of the duplicature of the membrana tympanic as out of a fheath,y^. 1 4. From this time it gradually increafes, and grows lefs elaftic, On . L E C T U R E II. 69 On the edges of the annulus is ftretch- Membrana ed a double membrane, well known by tympan1 ' the name of membrana tympanic plate i. jig . 1 2. n. plate n, jig. 8 . <2. At birth thele membranes are ealily feparated. V al- falva fays, the internal one is a produ- ction of the dura mater ; and the external a membranous expanlion of the skin that lines the meatus auditorius externus . But to me they feem both to arife from the membrane, that lines the cavitas tym- pa 7 ti ; for the external is a continuation of the internal, which, when raifed near the annulus , manifeftly appears to be con- tinued round that bone to the internal, and the bone to be contain’d in, or lur- rounded by the two membranes. T he in- ternal membrane may always in foetuses , with proper care, be traced to that which lines the tympanum. The injections of the great Ruyfch has put it paft dilpute, that thefe mem- branes are well fupplied withblood-vef- fels. But in foetuses , and very young in- fants, the membrana tympani is covered by a peculiar white tegument, analogous to a membrane, plate i .fig. 1 2 .m. which Ruyfch found to have no blood- veffels, and Human Osteogeny*. and therefore was by him fuppofed tc be a continuation of the cuticle. But, Du V erney thought it was only a mu- cilaginous fubftance, indurated into a membrane. To me it feems to be part- ly mucilaginous, and partly membra- nous; becaufe the external part of it, which is always white and foft, may be eafily walhed away, or rubb’d off from the internal part, which may, with care, be traced to the cuticle, or membrane, that lines the meatus. Valsalva fuppofes this mem- brane to be -often the caufe of deafnefs, when it does not come away, which he thinks might be relieved by furgery. The ule which nature defigns it for, probably is to prevent, for fome time af- ter birth, founds operating much, if at all, on the organs of hearing. The lituation of the metnbrana tym- panic in foetuses , is not near fo horizon- tal, as that of adults. It is always kept ftretched by the handle of the malleus pulling it inward, by which is caufed ex- ternally a large conoide cavity. That this membrane fometimes has a perforation in adults, is paft difpute ; but Lecture II. 71 but whether there fhould naturally be one, I much queftion ; becaufe, by the many experiments I have made, I never yet could force air, either thro the exter- nal meatus into the cavitas tympani , or thro the Euftachian tube into the mea- tus. I n foetuses under five months the two membranes, that form the membrana tympani, are aim oft wholly feparate; the internal one making, together with the membrane that lines the cavitas tympa- ni , a fort of bag, in which the fmall bones of the ear are contain’d, and the exter- nal membrane is but loofely ftretched, and is not pulled inward by the malleus , platen, fig. 2. c. When the membrana tympani is re- The bones moved, the fmall bones of the ear areap- ot che ear ' parent, which are next to be defcribed. They are four in number, known by the names of malleus, incus, os orbicular e, and Jlapes, plate ii. fig. 7. At birth all thefe bones are very little lefs than at maturi- t)'> fig- 15 -fig- 1 7- fig ■ z 9 - an d fcarce- ly at all differ from adults, except in the folidity of their fubftances, The 72 Human Osteogeny. Malleus, The head of the malleus is hollow, and thefubftance of the neck, fmall pro- cefs and handle are cellular, Jig. 1 6. all which in adults are folid. The carti- lage, that covers that part of the head, which is articulated with the incus ^ ap- pears to be a little thicker than at matu- rity, and the long procefs is a little thin- ner than an adult on fig- 7. a fig- 15.#. Incus . Th e body and legs of the incus ^ or anvil, are hollow, f 1 8. The cavity on its head, in which is received the head of the mal- leus lined with a cartilage, which, tho very thin, is thicker than in an adult. At the top of its fhort leg there is a fmall cavity, which in adults is fcarcely via- ble, as there is alfo in the fame leg a fmall roundifh one, in which a ligament is fixt. The os orbicular £, fig. 1 j.c. is fo fmall, that itsexiftence has been often queftion- ed. At birth I cannot difcover any dif- ference from the adult, except in its ar- ticulation, which then is fo loofe, that, before it is dried, it may be plainly per- ceived, by moving the bone gently with your finger. The Lecture II. The Jlapes , fo called from its refem- blance of a ftirrup, is not now fo per- fectly of that drape as it is at maturity. i t is not difficult in foetuses to difco- ver the periojleum of thefe bones, tho it is much finer than the periojleum of the other parts ; therefore I think it ftrange that fo many authors ffiould report them to have none. I t is almoft three months after con- ception before any of thefe bones be- come vifible. At three months, what is form’d of the malleus is entirely carti- laginous, as is all the incus , except at the top of its long leg, where there is fome- times a fmall offilication. The head of the Jlapes is a little offified. At four months the head of the mal- leus is a little offified, and its long pro- cefs, which then appears like a fine hair, but is not more than the tenth of an inch long, and the little procefs alfo is offifi- ed ; but the neck and handle are then cartilaginous. The head of the incus is partly cartilaginous, as alfo the extre- mities of both its legs. The os orbicular e is juft vifible. The bottom of the legs of K the 73 Stapes o HumanOsteogent. the Jlapes is cartilaginous, but the bails is ofiified. At five months the head of the mal- leus is perfectly ofiified, as are likewife all its other parts, except its neck and handle. The incus is all ofiified, except at the extremity of its fhort leg. The os orbicular e is yet cartilaginous. The Jla- pes is perfectly ofiified. At fix months all parts of thefe bones are ofiified, and differ from full grown ones only a little in fize, except the Jla- pes , the body of which is then much rounder than it is afterwards. At three months after conception thefe bones touch the fides of the cavity they are contain din, which cavity is not fo large, in proportion to the fize it af- terwards grows to, as thefe bones are. At both three and four months, the long leg of the incus and the handle of the mal- leus almoft touch one another, which af- terwards gradually recede from each o- ther. The body and fliort leg of the incus at four months juft touch the ex- ternal femicircular canal, from which afterwards, by the increafe of the cavity, it is gradually removed, At the fame Lecture II. 75 time, the head of the ft apes is very near the cavity, which contains its mufcle ; but at five months, and afterwards, that cavity is removed further from it. All thefe bones, from their firfi: ap- pearance, until almofi: fix months after conception, feem to be clofely enveloped by the membrane that covers the cavi- tas tympanic and forms the inner part of the membrana tympani. But when the cavity becomes much bigger, and the bones at a greater diftancefrom itsfides, then part of that membrane forms liga- ments, by which the head of the malleus andth e. incus and its fhort leg are fixt to the fides of the cavity; which ligaments are, fo foon as form’d, much the fame to appearance as in adults, except in their length, in which refpect they increafe a little, as the cavity enlarges. W e now come to examine the vari- ous cavities contain’d within the os pe- trofum , which are part of the organs of hearing. The largeft andmoftconfiderable of ‘Tympanum, thefe is call’d the tympanum^ or drum; it is divided into three parts, the anterior, pofterior, and middle. K 2 The 7 6 HumanOsteogeny. The anterior is that, in which the tuba Eufiachiana opens, and where the canal of the muf cuius intervals mallei is fituat- ed, by Du V erney called femicanalis , which in the foetus runs Ifraight from the foramen ovale to the orifice of the Eu- ftachian tube, and is much narrower than in adults. The hinder part of the tympanum, commonly called cavitas or fnuofitas rnaftoidea, is at birth muchlefs than in a- dults ; becaufe the mafloide apophyfs , in which a great part of it is afterwards con- tained, is not then generated. The middle of this cavity, in which the fmall bones of the ear are contain’d, is lefs at birth than at maturity, efpeci- ally its inferior part ; the cells or fmall caverns of which are not then near fo nu- merous or large, as they are afterwards. All the protuberances in it are confi- derablyfmaller. The forameti ovale is as long, tho not fo wide. The rotundum is rounder than in an adult, and turn’d more toward the ?nembrana tympani. The fmall bony fibres, which in adults may be feen going from the inferior fide Lecture II. 77 of the cavity to the protuberance of the cochlea , I never found in foetuses. A full grown fetal cochlea is rather cwhUa & lefs than an adult, y>/. ii .fig. i o. a. but the canalesfemicirculares , b.c.d. are much of res - the fame fize, except at their openings, which feem to me to be fomewhat larger. The membrane or periofteum, that lines all the cavities of the ear, is at birth exceeding fine, tho it is much thicker than it is at maturity. The cavity of the tympanum in foe- tuses of two months, is fcarcely vifible, and the membrana tympani lies almoft flat on the petrofum ; for the fmall bones are then imperceptible, but th z foramen ovale and rotundum , and the femicircu - lar canals and cochlea , tho very fmall, may be perceived. At three months the cavity of the drum is form’d, but the protuberances in it are hardly vifible, except that of the cochlea , which touches the membrana tympani. Both the foramen ovale and rotundum^ tho very fmall, are, in propor- tion to the fize of the cavitas tympani , much larger than in an adult, and they both are parallel to the membrana tym- pani , H uman Osteogeny. pani. The rim of the foramen rotun- dum is then oflified. The figures of the cochlea and canales femicirculares , tho now cartilaginous, are much the fame as in a full grown foetus . At four months the cavity of the drum is much enlarged, and the begin- ning of the cavitas majloidea is formed. The protuberance of the cochlea is then ol!ified,and is at a greater diflance from the membrana tympani. At five months the upper fide of this cavity is much increafed, and the infe- rior begun to be generated. The cana- les mufculi Fallopii , Euftachii , and Jlapi- disy are now oflified. A t fix months the cavity is wholly oflified, and is pretty much enlarged, from which time it gradually increafes j and about feven months the fmall cells or caverns in it begin to be generated, and the foramen ovale is much the fame as at nine, but the foramen rotundujn is not then turned toward the inferior fide of the cavity, as it is in the next month, plate ii .fig. 7. c. fig. 9. a. b. The next bone to be deferibed, which is common both to the face and skull, is called Lecture II. called fphenoides , or cuneiforme , plate ii. jig. 2 o, 2 1 . This has the greateft variety of parts, diftinguifhed by different names,, of any bone in the body. At birth it confifts of three diftinct bones, conned- ed together by membranes and carti- lages, which afterwards become infepa- rably united. The middle, or thickeft part, by which it joins the vomer before, and the fourth bone of the occiput be- hind, I lhall call its body, fig. 21. a. a. the hinder part of which is now cartilagi- nous,^”. 20. c. and as for the two bones, which are join’d on each fide to it, I fhall, as Ingrajjas does, defcribe them under the names of the great wings of the fphe- noides , b. b. I begin with the body, on both the external, as well as interna! parts of which are feveral confiderable apophyfes . Internally, there are two fharp tranfverfe procefles, call’d the little wings of this bone, jg. 20. g. g. Thefe form the hinder part of the upper fide of each orbit, and the upper fides of the fuperior orbitary fiffure,and are nowoffified,tho their figure differs a little from adults. The anterior fides of thefe apophyfes are Human Osteogeny. loofely connected by membranes to the hinder fides of the orbital proceftes of the frontal bones. In the middle be- tween them there is a notch h> in which is received part of the os ethmoides. Behind the little wings there are four other proceftes, called clmoides ; the two anterior are now oftified, f. f but the pofterior are entirely cartilaginous, d. d. Between thefe proceftes is a cavity, ge- nerally called fella Turcica, e. whichisall bone, except a fmall fhare of that part of it, which joins the pofterior clmoides , where it is cartilaginous. Externally, on the middle and fore part of this bone, there is a thick riling, which is the root or beginning of what is ufually called the azugos procefs of this bone; becaufe it has not a fellow, as all the other proceftes have, fig. 21. d. The lower part of it is now received into the hinder part of the vomer by fchindylefs , and the top of it is joined to the nafal lamella c r the os ethmoides. At birth it is far from being perfectly form’d, but in fome fubjefls it is much more fo than in others. On each fide of this body there is an apophyfis , to which is fixtone of the great wings, Lecture II. 8r wings, which apophyfis is ftretched out backward toward the cuneiform procefs of the occiput, fig. 20. i. i. O n each of the great wings of the fphenoides are four apophyfes, diftinguifh- ed by the names of temporal) orbital^pte- rygoide) and fpinal. The temporal procefs makes part of the temples, under the zygomatic pro- cefs of the os mal<£) and the anterior part of the fame named procefs of the os fqua - mofum) plate i. fig. 1 . 1 . plate ii .jig. 21. e. It joins the hinder edge of the os mal & , and runs a little under the anterior one of the fquamofum. Its fuperior edge is not grown enough to touch either the frontal or fyncipital bone, but there is a fmall aperture between them, in which aperture, plate i. fig. 1. you may fee the beginning of three ojfia Wormiana. At the lower and back part of this procefs, there runs out a fpinal one un- der the condyloide cavity of the os fqua - mofiumfin foetuses ) almoft quite to the an- nular bone. O n the anterior edge of the tempo- ral procefs, is join’d almoft, at right an- gles, the orbital procefs, which forms a L great 82 HumanOsteogeny. great part of the hinder hde of the or- bit, the fuperior edge of which is very loofely join’d by membranes, that cover it, to part of the external fide of the or- bital procefs of the os frontis , plate ii. fig- 2i -f A t the bottom of the temporal and orbital procefles is the apophyfis, called pterygoides , or aliformis , from its fuppof- ed refemblance to a bat’s wing, plate i. fig . 2. d. It is divided into two alee, the internal of which is very much lefs, in proportion to what it is in adults, than the external. The cavity between thefe alee, in which the internal perifiaphyline xnufcle riles, is not formed, but the hook at the top of the internal ala , e. round which plays the tendon of the juft nam- ed mufcle, is perfectly generated. The number of perforations, thro which confiderable nerves and blood- velfels pals, are in a full grown foetal f phe- nol de bone the fame as in adults, and dif- fer only from them alitde in their mag- nitude, which is generally greater, in proportion to the lize of the bone, than in adults : But thofe fmall holes at the bottom of the fella Turcica , are oftner more Lecture II. 83 hiore in number and larger than in a- dults, plate ii .fig. 20. e. A t birth there is only the beginning of the large cavity, which in adults ge- nerally is to be feen in the body of the fphemide bone, and then it is almoft fill- ed with cartilage. At two months after conception, the place of the os fphenoides is liipplied, part- ly by membranes, and partly by carti- lage, the body being entirely cartilagi- nous, and the great wings not generated. About three months the great wings begin to appear, and three fpecks of of- fification are to be feen, one in the bo- dy, and one in each of its fmall wings, plate ii .jig. 2$. a. b.c. About four months the great wings are much increafed, and there are now fix oftifications in the body; two in the little wings, which are now pretty long, two in the anterior clinoide apophyfis , and two in the fella Turcica : fo that at this time, as Kerckringius rightly obferves, this part confifts of eight diftinft bones, befides cartilage, fig. 24. At five months the great wings are almoft form’d, and the little wings are L 2 near 84. Human Osteogeny. near oftified, and a confiderable part of the body is become bone. A t fix months the great wings have aim oft the fame fhape they have at birth, Jig . 22. except the inner ala of the pte- rygoide apophyfis , the beginning of which is then fcarcely form’d. The little wings are entirely oftified, jig. 23.^. g. except at their roots, h. where they join the body of the bone, and are much broad- er, in proportion to their fize, than they are a month or two afterwards. The middle of the body of the bone e. is ofti- fied, as are its lateral procefles,to which the great wings are join’d, ii ; but its a- xygos procefs is cartilaginous, and its clinoide proceftes, d.d.f.f. About feven months the oftiiications are almoft as much compleated as at nine. Os Eth- The laft bone, which is common to znoides. If* 1 4 *1 1*1 the race and cranium , is the ethmoidesy which is fituated in the middle and fore part of the skull. At birth it is compof- * ed of various parts, fome of which are oftified, and others intirely cartilaginous. That part, which is placed horizon- tally between the orbital apophyfes of the frontal L E C T U R E II. 85 frontal bones, which is always full of fmall holes, from whence it is called la- mella cribrofia, is entirely cartilaginous, as is alfo that part of it, which is called thenafal lamella, plate ii-fig- 26. a. from its making the fieptum naji , and the pro- cels commonly call’d crifiagalli b . which paffesthro the middle of the lamella cri- brofia into the cavity of the skull. The parts of it, which are called ojfa fpongiofa , or turbinata fuperiora , are pret- ty much olhlied, efpecially where they join one another, f 28. a. but their pofte- rior parts gradually decreafe in breadth, and end in two very llender cartilages. The fubftances of thefe olTilied parts are rather more fpongy than in adults. O n the external lides of thefe bones, there is a thin fmooth lamella, called os planum, fig. 29. b. which makes part of the inner Tide of the orbit : This now is almoft furrounded by a cartilage, which runs under part of the orbital procefs of the fuperior maxillary bone and the os unguis, a . a. a . At four months after conception the os ethmoides is altogether cartilaginous; but the ©Ififkations of the offa plana be- Human Osteogeny. gin foon after, and at fix months they are as much oflified as at nine; as like- wife by the fame time, or foon after, are the ojfia fpongiofa , altho they do not be- gin to offify by near a month fo foon as the plana :, fig. 30. T h e bones of the face are now to be defcribed, which are divided into thofe of the upper and inferior jaw. The number of the bones of the up- per jaw are the fame in full grown fice- tuses as in adults, except the teeth, which I never found at the time of birth to exceed twelve in number. The firft of thefe bones are the ojfia nafifio named from their fituationatthe fuperior part of the nofe, platei. fig. 1 . m. plate ii. fig. 2 8. c. They are at birth fo perfectly form’d, as not to differ fcarce- ly at all in their external furfaces from adults; but on their internal tides they are rougher and more porous. * Their connexions, above to the na- fal apophyfes of the frontal bones, and la- terally to the fame named proceffes of the upper maxillary bones, and to one another, are loofe, and altogether by membranes. These Lecture II. £ These bones, by the fourth month after conception, are generally as much form’d, in proportion to the bignefs of the foetus , as at nine. They offify, and acquire the lhape they ufually have at birth, when they are fo fmalJ, that it is impoflible to obferve the manner of their production. The ojfa unguis are fituated at the in- ojc ternal corners of the orbits, pi. \-fig. i.n. They are at birth perfectly offified. The tide of each of them next the orbit is as fmooth as the os planum , and its fubftance much the fame ; but the fide next the nares is rough, plate iii. fig . i. Its an- terior part, v/hich has a fiojfa , or groove, in which the lachrymal bag and part of its duCt is contained, from whence it has the name of os lachrymale , is full of fmall holes, and is very thin and brit- tle. These bones are joined to the offa frontis and maxillaria fuperiora by mem- branes, and to the offa plana both by membranes and cartilages. About four months after conception they arefo fmall and thin, as to be fcarce- ly vifible to the naked eye. Between 88 Human Osteogeny. Between five and fix months, they are partly ofiified, and between fix and feven months, they are almoft as much form’d as at birth. ojfa mala- T h e ojfa malar uni are two irregular fhap’d bones, with four corners or points. At birth they differ very little from a- dults, except at their ends and fides, w here they have not, like adults, indentations for their better and ftronger connexions with other bones; but are loofely joined by membranes to the bones they touch. •plate i. fig. i. o. plate iii. fig. 2. At three months after conception the ojfa malarum begin to be generated, and have, by the fourth month, nearly the ufual fhape of full grown fcetal ones, and are perfe&ly ofiified,^. 3. OJJa max- The ojfa maxi liar i a fuperiora are the ' priori* largeft bones of the face, plate i. fig . 1 . p. fig. 2. a. a. The external parts, which form the greateft fhare of the upper jaw and bottom of the orbit, do not differ very much in fhape from adults. The nafal apophyjis of each bone is rougher, plate i .fig. i.q. and has, on that part of it next the orbit, juft before the edge of its inner fide, a mallow groove, XA Lecture II. in which are feveral fmall holes. The top of the nafal apophyfis does not end fquare and rough, like adults, but is rounded off, plate iii. fig. 4. a. and does but jufL touch the frontal bone, to which it is loofely join’d by membranes. The orbital procefs is more concave and porous at birth than afterwards, fig. 4. b. There is then the appearance of a future along the middle of that part of the bone, which covers the ca- nal, thro which paffes the fecond branch of the fifth pair of nerves. That part of the bone, which is hol- lowed for the reception of the os malce y fig. 4. c. and is covered by it, is full of fmall holes, and has higher edges and fharper, without indentations, than a- dults ufualiy have, and at the bottom or extremity of it, there are not any rifings or many inequalities. Under the orbit the bone is thin and porous. The internal part of the os 7 naxillare fuperius may be divided into two parts, that which forms the anterior or great- eft part of the palate, together with the fockets of the teeth, plate i. fig . 2. a. a . 1,2, 3, 4, 5, and that part which makes M the HumanOsteogeny. the bottom and fide of the nares , pi. iii, fig- 5-e-e-e. The firft mentioned part is tituated horizontally, the upper furfaceof which makes at leaft three fourths of the bot- tom of the nares, and the inferior fur- face as much of the palate. It is much thinner, and as porous as in adults. At its anterior part there is a future, extend- ed crofs the palate, generally from the internal edge of the dens caninus on one fide, to the fame edge on the other fide, plate i. fig. 2 . b. Juft before the middle of this future is the foramen mcifivum , much larger, in proportion to the fize of the bone, than in adults. The divitions of the fockets of the teeth are but few, and exceeding; thin and brittle. The tide of this bone, next the nares, is al- moft covered by a thin bony lamella, un- der which Hides part of the os palati. The antru?n Highmomanmn is pretty large, plate iii. fig. 5. f tho not fo big, in proportion to the tize of the bone, as in adults ; no part of it is now covered by the os palati, as it is afterwards. The patiage for the lachrimal dud is fmall, b. These Lecture II. pi These bones are connected to one another, along the middle of the roof of the mouth by fymphyfisy above which connexions, within the nares, is fixt the bottom of the vomer on a very fmall ridge, much lefs, in proportion tothefize of the part, than in adults. About three months after birth a great part of thefe bones is form’d, but fcarcely any cavities for the teeth. At four months they have pretty near the fhape of full grown fcetal ones, pL iii. fig. 7. and at the future, which is at all times of life vifible crofsthe anterior part of the roof of the mouth, each bone is generally divided into two diftinct parts, from between the dentes canini and in- cifivi up to the bottom of the nofe. The horizontal part now has the bony lamel- la on its fuperior furface. Between five months andnine there is but little variation, except in the gra- dual forming of the rim of the orbit and the foramen juft under it, called or biter externus , the lachrimal du3 HumanO STEOGEN Y. the bags there is always to be found, be- fides the teeth, a mu cilaginous fubftance. N o bony part of the body is fo uni- formly folid,or near fo hard, as this part of the teeth is in its infancy, in propor- tion to its thicknefs. There is not at birth, as Eujlachiut * imagin’d, the leaft appearance, thatl cou’d ever find, of the layer or row of teeth, by which the fir ft is afterwards ufually thruft out. Between four and five months after conception, the points of thefe fhells are generated, at which time they are fo jfmall, as to be eafier felt than feen. About fix months, they have almoft the fame fhape as full grown fcetal ones ufually have^/gii 8^.1 9. except the mo- tores, which are often in three or four parts* The long time, which nature takes before fire perfects any of thefe parts, af- ter they are begun to be generated, feems to be deiigned to produce their great hardnefs and folidity,by a very flow and gradual, tho conftant, appofition of new matter. And the very early decaying of fuch teeth, which, by inciftons, have * Opufcula de dentibus. X been 99 Lecture If. been permitted to penetrate the gums, fome time before nature intended they fhould, makes it, I think, manifeft, that all the time they are naturally contain’d within the jaws under the gums, is ab- solutely neceffary for the true and per- fed: formation of their external part, commonly called their enamel \ from the fuppoled refemblance it has to luch a vi- treous fubftance. I would by no means have what I juft mentioned, to be the caufe of teeths decaying very foon, tho it is certainly true, to be ever ufed as an argument to dif- fuade any from cutting infants gums, efpecially when violent and dangerous fymptoms appear - becaufe I have often feen children, dying, as was imagined, receive immediate and great relief by that operation, even when their gums did not appear in the leaft to be fwelled, But the method of drawing the teeth of children between five and feven years of age, if they are in the leaf! rotten, and Sometimes, as I have more than once feen, even when they are perfedly found, which is thought by many people necef- fary to caufe the fecond fet of teeth to N z grow oo Hu man Osteogeny. grow even and uniform, ought to be ne- ver ufed, altho what is intended by it may generally be produced ; becaufe, by fome experiments I have had reafon to think, that the enameled part of a tooth never increafes after it has pe- netrated the gum. And, I believe, it will always be found tobefaCfthat thofe children, who cut and died their teeth the lated,condantlyha ve the bed, and fuch as continue die longed in perfection ; there- fore the pulling out of the fird teeth, be- fore they are loofen'd by the fecond, mud caufe the fecond to fhoot out of the jaw before theyotherwife would, and confe- quently before they are compleatly form- ed. 'r, aides. Before I come to condder the bones of the trunck, there remains a little bone to be defcribed.called os hyoides , plate iii. Kerckringius * gives no defcription of it, and the reafon he alledges for his fo doing, was, non quia Galenus illud in li- bello de offibus prceteriit , fed quia in fce- tibus ne quidem cartilago ejus appareat. Hence it is plain, he had not with pro- * Ofteog. feet. c. ii. per IOI Lecture II. per care fought for it ; becaufe, at birth, it never has lefs than three diftin£t ofli- fications, fig. 20. a. a. b. and its figure is much the fame as that of adults, and, in proportion to the fize of the foetus, much of the fame magnitude. Each of its horns then is joined to its body by a liga- ment, which makes a fort of articula- tion, c. c. I n foetuses , under three months old, its place is always filled with a cartilage of the fame form. Under the age of eight months, I never found any oflihcation in it ; but fbon after that time it begins to oflify in the middle of itsbafis,^. 22 .a. and be- fore nine months, there are two points of offification generated in each of its horns, which, by the time of birth, ge- nerally unite, and form a long bone a- bove half the length of the horn,^. 21. a. a. I am now to confider the bones of the fecond divifion or part of a skeleton, which are thofethatcompofe thetrunck. They are divided into three parts, thofe of the fpine , thorax , and pelvis . The 102 Human Osteogeny-. The fpine. The fpine is that congeries of articu- lated bones, which reach from the bot- tom of the occiput to the extremity of the rump; the number of which in foetuses is thirty three, and fometimes thirty four. The twenty four fuperior of thefe bones are called true vertebree , feven of which belong to the neck, twelve to the back, and five to the loins. Thofe be- low the loins are called falfe vertebra , the five fuperior, and fometimes fix, be- long to the os facrum^aA the four inferior to the os coccjgisy plate iv. fig. i . fig. 7. The vertebra in foetuses are very dif- ferent from adults. For, except the firfl of the neck, which confifls of two bones only, and the fecond and laff, which have more, all the true vertebra have three bones joined together by cartilages. That which now forms the body of each vertebra'^ a thick, flat, cellular bone, fig. 1 1. furrounded almofl by cartilages, except at its anterior part, which has a cavity, that is covered only by the ftrong and thick membrane, which is extended overall the external parts of the bodies of the vertebra . On Lecture II. 10 O n each fide of the body of each vertebra there is a bone, which runs back- ward, and is joined to its fellow on the other fide by the cartilage , which is in the place of thefpinal apophyjis^jig. 6. a.a.d 1 Thefel fhall call the lateral bones of foe- tal vertebrce. On their anterior ends are the proceffes, which are called tranf- verfe, c. c. and oblique, e. e. The tranf- verfe proceffes of the vertebrce of the neck, which are perforated at birth, have only their pofteriorfides formed by thefe bones, all the anterior being then carti- laginous, except the laft, which gene- rally has a fmall bone on its anterior fide, join’d to thepofterior by cartilage, Jig. 4, c.c. The tranfverfe proceffes oi thedor- fal vertebrce are, except juft at their ends, entirely hone, fg. 5. c.c. but the lumbar are more cartilaginous, jig. 6 . c.c . The oblique proceffes of all the vertebrce are bone, covered with a very thin cartilage, and in foetuses much alike. The fir &verteb?*a of the neck, which is called atlas^fig. 2 . has its anterior part entirely cartilaginous, b . and its two la- teral bones are joined behind together by a cartilage, which is in the form of an arch. Vertebra; of .he neck,. CA o 4 H u man Osteogen y. arch, d. The fuperiorpartof the anterior ends of the lateral bones are hollow, and covered with a thin cartilage, by which the greateft part of the cavity, where- in the condyles of the occipital bones are received, is formed, e.e. The tranf- verfe proceffes of this vertebra are larger than all the reft, except the laft, c. c. The fecond vertebra , commonly call- ed dentata ) from its tooth-like apophyfes on its body,y^. 3 .b. is always at birth com- pofed, beftdes cartilage, of at leaf!: four bones, andoftenftveorftx. One forms its body, on which is another feparated only by a cartilage, that makes the root and great part of the body of the tooth-like procels, and two lateral bones, the hind- er ends of which are join’d together by a cartilage. On each fide of the body, at the root of the anterior ftde of each tranfverfe procels, there is often a fmall round oftiftcation, which fometimes is only on one ftde. The other five vertebras of the neck never have more than three bones in each at birth, except the laft, which, as has been mentioned, has a little bone on the anterior ftde of its tranfverfe proceffes, Lecture II. 105 that makes the number of its bones to be five. The forkednefs of the cartilages of thefe vertebrae, which are in the place of their fpinal proceflesj fig . 7. decreafe gradually as they defcend, and the laft fometimeshasfcarcely any, fig. 4 .d. and fometimes ends in a point like thedorfal. The dorfal vertebrae are all alike in o° r ^i r 1 • r 1 r I vertebra. form, but in lize they vary from each o- ther much in the fame proportion as full grown foetal ones. The tranfverfe pro- cefles are not fo long, in proportion to the lize of the vertebrae, as in adults, but are roundifh, and topp’d with a round cartilage,^*. 5. c. The inferior edges of their lateral bones have join’d along them a narrow thin cartilage,^. 7. and the cartilages, that are in the places of their fpinal procefles, end in acute angles, which lie flat, pointing downward, f 7. Those parts of thefe vertebrae, on which die ribs are articulated, are entire- ly cartilaginous. The lumbar vertebrae confid: of^miw three bones like the dorfal, their tranf- verfe apophjfies are fliort, and molt- ly form’d by cartilages, fig . 6. c. c. The O pofterior 10(5 HumanOsteogeny. . pofterior ends of their lateral bones are broad and round, furrounded by a narrow cartilage, fig. 6 . ff and is a continuation of that which is in the place of the fpinal procefs, d. that ends in a fork pointed downward, above which there is a cartilaginous ridge. Os/acrum. The parts of the os facrum are at their bodies articulated together, much in the fame manner as the true vertebra but their tranfverfe apophyfes are all fo join’d together by a cartilage on each fide, which runs the whole length of the facrum , gradually decreafmg in its thick- nefs, until it becomes very fmall, fig. i > a. b. that thefe falfe vertebra cannot, like the true ones, be feparated by only remov- ing the ligaments of their articulations,, without cutting thefe lateral cartilages. The two fuperior falfe vertebra al- ways, and often three, have their lateral bones joined at their pofterior ends by a cartilage, much of the fame form of thofe which are in the place of the fpinal proceffes of the dorfal vertebra , fig. 7 . The two fuperior parts alfo have, in their tranfverfe proceffes, fmall odifications, by which their bony parts are made five Lecture II. 107 In number ; but the other three or four parts have never more than three. The lateral bones of the two lowed: parts al- ways, and fometimes three, are not, at their pofterior ends, join’d by cartilage, but by a membrane. O n the pofterior fide of that part of each lateral cartilage, which is connected to the tranfverfe fpines of the two fuperior parts, there is an uneven fhallow cavity, in which are received thefmall protube- rances on that part of the ilium, which by fymphyfes is joined to the os facrum. None of thefe falfe vertebra have oblique precedes, except the fuperior, where it is articulated with the laft ver- tebra of the loins. The four laft bones of the fpine, Os coccygis, which form the os coccygis, and in adults are not only often united together, but alfo with the os facrum, are at birth ge- nerally four diftind cartilages,^-. 1.31, 32,33,34. tho once or twice I have feen in the two fuperior afmall offification at that time. The fuperior is pretty large and flatifh, the fecond is fomewhat lefs, and the two laft are pretty nearly of a fize, and almoft round. The 10S Human Os teo gen y. The paffage for the medulla fpinalis along the fpine in foetuses is much of the fame fize, in proportion to the mag- nitude of the foetus , as in adults ; but the holes between the tranfverfe pro- cefles of the vertebra are much larger. At two months after conception the fpine is generated, and part of its pro- cdles, all which are then entirely car- tilaginous. Very foon after three months, there are ofiifications in all the bodies of the vertebra , except in the fird: of the true, and the five inferior of the falfe, fg. 1 2. About the middle of the dorfal vei'tebra the odidcations are the larged; , and gradually decreafe from thence, both as they afcend to the top of the neck, and as they defcend to the os facrum. The lateral bones of the fird: ver- tebra are pretty much ofiified ; from thence the ofiifications of all the other lateral bones of the fpine gradually de- creale, until it is in thofe of the lowed lumbar vertebra fo {mall, as fcarcely to be perceptible. At the fourth month the edifica- tions of the lateral parts of all the os facrum are begun, *• At Lecture II. 109 At the fifth month there are offi- fications in every body and lateral part of the os facrum. At the fixth month the oflifica- tion in the tooth of the fecond verte- bra of the neck is begun, and the an- terior fide of the tranfverfe procefs of the laft vertebra of the neck is often now oflified, as alio all the roots of the fame precedes of the dorfal vertebroe. At the feventh, fometimes, and ge- nerally the eighth month, there are fmall points of oflification in the tranfverfe proceffes of the upper part of the os fa- crum , and often in the fame places of the fecond. What are ufually called the bones of the thorax , are only the ribs and fer- rax . num y tho the dorfal vertebree form the middle of the hinder fide of the tho- racic cavity. In all foetuses , before the lungs have been filled with air, the anterior part of the cavity ig much flatter than it is afterwards ; for I have always found then the cartilaginpus parts of the ribs almofl quite ffraight, and the lower end of the flernmn much nearer the fpine ; which s I IO Human Osteogeny. which, as foon as the child has breathed, is forced further out, and thereby the cartilages of the ribs are curvated, and confequently the cavity enlarged. Ribs. The ribs in full grown foetuses do not differ greatly from adults, except at their pofterior ends, where they are a little more cartilaginous; although their arti- culations with the dorfal vertebra are exactly the fame, and their tubercles perfectly offified. The f ulcus for the intercoftal arteries, veins, and nerves to pafs in, are at birth formed, and the roundnefs of the fuperior hdes of moft of the ribs, and the fharpnefs of the inferior is in much the fame proportion as in adults ; but their curvature is not fo great, efpecially that of the falfe ones. All foetal ribs differ from one ano- ther in the fame manner and propor- tion as adult ones naturally do ; there- fore it is foreign to my purpofe, at pre- fent, to relate the particular difference between each of them, plate iii. fig. 2 8* fig- 29 , fig • 3 1 °>fig- 3 1 > fig- 3 2 > fig- 33- The anterior cartilaginous end of the firft rib is perfectly united with the fu- perior part of the fiernum y fig, 24 , 1 . * The 0 Ill Lecture li. The fame ends of the fecond, third, fourth, and fifth ribs are articulated with the Jiernum in femilunar cavities on the fides of it, fig. 24, 2. b. 3. b. 4. b. 5. b. Which articulations are often by age entirely obliterated ; but the fame ends of the fixth and laft true ribs are ge- nerally clofe to one another, and lie on the fore part of the Jiernum , being there tyed by membranes to it, the ends of thofe on one fide being near thofe of the other, fig. 24. 6, 7. c. The earth laginous ends of the five inferior or falfe ribs are connected to the laft true ribs, and to one another, by their inter- coftal mufcles, and a pretty ftrong li- gament. The internal fubftance of the ribs is much the fame as that of adults, fig. 25. 61* Cl* Cl* ci* Before two months after conception the greateft part of the true ribs are generated and oftified ; and then dif- fer from full grown foetal ones only at their pofterior ends, which are cartila- ginous from a little above their tubercle. In the fame manner are the falfe ones, except the laft, which is fb fmall, as fcarcely 1 X 2 H uman Osteogeny. fcarcely to be perceived, efpecially m bony part, if there be any. The arti- culations of both ends of the ribs are now perfectly diftindt, tho Kerckringius * affirms the contrary. Between the third and fourth month thefe parts are fo near perfected, that there appears no material difference in any of them from thofe of nine months, except in magnitude, fig. 34. jig. 35. fig- 3 6 - fig- 37 - Sternum. The ftemum at birth is not curv- ed, as in adults, and always conliffs of two parts, which are articulated toge- ther in the fame manner as the cartila- ginous ends of the ribs are, which, in all the fubjedts I have examined, is ]uft at the middle of the articulation of the fecond rib \ where it is ar- ticulated both with the fuperior and inferior part of the Jlernum , plate iii. Jig. 24. a. b. The ffiape of the upper part of the jlermwi is much the fame as that of adults, and has, as I have already ffiewn, the cartilaginous ends of the ffiff ribs * Qftecg. feet, cap, xiv. united Lecture II. i to 3 united with it. By the articulation of this part of the Jlernum , there feems to be a motion peculiar to it, and different from the other part ; for when the ca- vity of the thorax is dilated, the fuperi- or end of this part feems to be pufhed in- ward and depreffed, and its lower end pufhed outward and raifed. On the top of this part are articulated the ante- rior ends of the clavicles,^. 25. c. With the inferior part of the Jler- num the cartilaginous ends of the ribs, as has been lliewn, are articulated ; and at the bottom of it there is a procefs, called enjiformisy tho itsfhape is very va- rious in different fubjefls, as you fee in the preparations, jig. 24. d. jig. 25. d. fig. 26. d. The greatefl part of the Jlernum at birth is cartilaginous, with various ofli- fications in it, about the number of which there have been many difputes, which I think to have been very trifling; becaufe if thofe enquirers had examined a vari- ety of fubjecds, they would certainly have found, that fcarcely two different jler- nums of the fame age are offified alike ; as in the preparation, fg. 2 6. you fee on- P ' lv ' 1 14 HumanOsteogeny. 1 y one offification in the upper part of it, i. and three in the lower part, 2, 3,4. the inferior of which is very fmall. In the other preparation, Jig. 25. you find two large offifications in the upper part, 1,2. and in the inferior part, there is a large one at its top, 3. and five fmall ones below it, irregularly fituated, 4, 5, 6, 7, 8. Thus you fee Fallopius and Bar- tholin related the truth, when they rec- kon’d the number of bones in this part to be fometimes eight ; tho * Kerckrm- gius feems to have thought their num- ber never to exceed fix. I, in one fubjedl not nine months old, found three offifi- cations in the upper part, and feven ir- regularly difpofed ones in the inferior. Before tw T o months after concepti- on, the Jlernnm is formed, and the arti- culation of its upper part with the infe- rior diftindt. Its fhape then is not mate- rially different from a full grown foetal one; it is then entirely cartilaginous, and fo continues generally until the fifth month, when one or two, and fometimes three fmall offifications are to be found in it; after which time, you may fee, by * Ofteog. feet. c. xv. prepa- 11 $ Lecture II. preparations, the ofllfications are very various. The next bones to be defcribed are ojamm- thofe of the pelvis, commonly called ojja innominata. Each os innominatum is at birth compofed of three bones, join’d, at a diftance from each other, by an inter- vening cartilage, plate v._ fig. i . a. b. c. The fuperior part is diftinguiflied by Ilium. the name of ilium, a . It is a broad flat bone, with a femicircular edge, furround- ed by a femicircular thick cartilage, of about the breadth of the fourth part of the bone’s length, d. d. Its lower part is fixed in the carti- lage, which makes the upper part of the acetabidum , e. and joins it to the other bones. On the hinder part of its in- ner fide, there is a fmall - irregular cavity and rifing, by which it is articulated with the upper parts of the os facrum by fym- phyjis. Both the inner and exterior tides are pretty fmooth, and are both partly concave and convex. The fubftance of this bone is now much more fpongythan in an adult, and P 2 is 1 1 6 Os pubis. JfcbiUm. Human Ostkogeny. is rather thicker, in proportion to its mag- nitude,^. 2. The anterior part of the os innomina - turn is called os pubis , fig. i. b. It is at birth, at each of its ends, cartilaginous, and is not ofinied enough to form any part of the acetabulum. The hinder part of the innominatum , called ifchium , e. is, at its fuperior part, offified fufhciently to make the hinder part of the bottom of the acetabulum , which is the only bony part of that cavi- ty in foetuses. All the inferior and an- terior iides of the great foramen are car- tilaginous. The furface and depth of the aceta- bulum is much the fame as in adults. The connexion of the ojfa pubis to- gether is by membranes, and in fuch a loofe manner, as to be like an articula- tion, capable of permitting a fmall de- gree of flexion. O A little before three months after conception, the os ilium is partly oflifi- ed, but the cartilaginous rim is broader than the bone ; all the rdf of the inno- minatum is cartilaginous. At k Lecture II. 117 At three months, or a little after 3 thefe parts have almoft the fhape of full grown foetal ones, altho the offifications are not begun in either of the ojj'a ilii or \fchii') fig. 3. About four months, there is fome- times to be found a very fmall oflifica- tion,near the top of the ifchium.fig. 4. a. and about the fifth month the os pubis begins to offify,from which time the of- fifications of thefe three parts gradually increafe until birth, without much va- rying the figure of the whole os inno - minatum . I am now come todefcribethofe parts of the skeleton, which to anatomifls are known by the names of its fuperior and inferior extremities. The fuperior extremities confifleach of them of four parts, the fhoulder, the arm, fore-arm, and hand. The fhoulder is formed by two bones, the clavicle and the fcapula. The clavicle , which is fituated at the ciaokie, top of the thorax tranfverfely, between the Jlernum and the fuperior epiphyjis of the fcapula , is fo perfectly offified at birth, that it differs very little from an adult / 1 18 HumanOsteogeny. adult in any thing, except its curvature, which is, I think, generally lefs, plate v. Jig. 5. and its articulations, both with the acromion and the Jlernwn , differ not in the lead from adults. A t one month after conception this bone is begun to be genera tedand offify’d, and it is perfected before mod of the o- ther parts begin to odify ; and then dif- fers in nothing but magnitude from full grown foetal ones, which is before three months after conception,^. 6. fig. 7. Scapula- The fcapula , at the time of birth, differs greatly from an adult, plate v. fig. 8. The bony rim of its bads, a. a. a. js much rounder than at maturity, and is furrounded by a large cartilage, at that part of the ficapula common- ly called its great or inferior angle, b. which is now rounded; from whence the cartilage runs almod in a draight line, b. c. growing very narrow, until it comes near the bottom of the fpine, c. where it widens, and makes an obtufe angle, from whence it runs up, and ends at the upper angle above die fpine, d. The two wided parts of this carti- lage are true epiphyfies , the offidcations of Lecture ll. no of which are not perfe&ed until after lixteen years of age. The fide of this bone next the ribs is not near fo hollow as in adults, and is much fmoother. The exterior fide of it is alfo fmooth, and the hollow, com- monly called cavitas Juprafipinata , is not near fo large. What is called its fpine does not rife quite fo high as in adults, and its end, which is joined to the epi- phyfis , called acromion , is not fo much curved or rounded, and therefore the edge, from the bottom of the fpine quite up to the top, is aim oft in a ftraight line, e.e. The inferior cojia of this bone is rounded much in the fame manner as in adults, f but the upper cofia is very thin, and more curved, g. The acromion is a broad flat carti- lage, curved inward, h. Under the a- cromion , at the upper ftde of the head of the fcapula , is another epiphyfis , called coracoides , which is now entirely carti- laginous; this is curved like adults, but ends in a fharper point, i. Its thick bafts is inleparably united to the cartila- ginous head of the bone, which now feems to be an epiphyfis , tho it is not, k.L The I 20 H uman Osteogeny. The glenoide cavity, in which is articu- lated the head of the humerus , is fhal- lower, and at its fuperior part narrower, than adult ones ufually are. At two months after conception, the fcapula has almoftthe famefhapeof one of three months, it has a fmall offifica- tion in its middle, and its epiphyfies are diftinft. At four months it differs from full grown foetal ones only in the length of its fpine, and the breadth of the carti- lage that furrounds its balls, which gra- dually decreafes as the bone increafes, jig. IO. Os humeri. The fecond part of the upper extre- mity conlifts of one bone, called os hu- meri. It is at birth ftraighter than in an adult, pi. v. fig. 1 1 . and from its top, a. for near three fourths of its length, it gra- dually lefiens, and then widens again, and grows flatilh,^. On the external lide of its lower end is a large deep cavity, c. in which is received the fupericr cpiphyfis of the ulna y called olecranon , when the fore-arm is extended. But at birth the anterior tide of this end of the bone is convex, and has not, as in adults, a cavity Lecture II. 121 cavity for the reception of the coronide epiphyfis of the ulna in the flexions of the fore-arm, nor the fmall cavity for the head of the radius ; and therefore the bone in this part is not near fo thin, in proportion to its flze, as it is after it ar- rives at maturity. The furface of the bone is fmoother,and more even than in adults, and has but one furrow in it, which is caufed by the tendon of the bi- ceps flexor cubiti. At each end of the os humeri there is an epiphyfis, both which at birth are entirely cartilaginous. The inferior is almoft exactly of the fame figure that part is ufually of in full grown bones, e. but the fuperior, which makes the head of the humerus , is much narrower at its exter- nal fide than in adults, d. The floffa, in which the tendon of the biceps is lodg- ed, is now formed, and has in it many fmall holes, in the fame manner as a- dults have. The fubftance of this bone is a little lets folid than an adult, and the middle of it is not fo hollow, fig . 1 4. a* a* b . The oflifications of this bone begin about a month after conception, in the fprm 122 H umanOsteogeny. form of a ring, when it is not thicker than a fmall pin, and yet the fuperior and inferior epiphyfes have much the fame fhape they have at birth, and are articulated perfectly difcinct , tho Ker- ckringius reports the contrary, Jig. 23. a. At three and four months, the dif- ference between the bone and a full grown foetal one is only in the epiphyfes , which are a little longer, in proportion to the fize of the bone, than afterwards, fig. 1 7. fig. 1 9. but at five months , 1 find no difference in the fhape of it from thofe of nine. The third part of the upper extre- mity is the fore-arm, which confifts of two bones, the ulna and radius. vb,a. The ulna is the longeftof the two, and is fituatedonthe outfideof the fore-arm, fig. 12. It is pretty fmcoth, and a little more curv’d inward than in an adult. No part of its body is triangular like adults, nor has it any remarkable protuberances or cavities, but is roundifh, and at its fu- perior end, a. thickeff, from whence it gradually decreafes almoft to the mid- dle of the bone, where it begins to in- creafe again, and grows gradually a lit- Lecture II. 123 tie flatter and wider until it ends, b. in the inferior epiphyfis , c. which is of the fame fhape as adult ones, tho now car- tilaginous, and has what is ufually call- ed the Jlyloide procefs, d. from which the ligament goes to the os pifforme or unci forme of the wrift. At the top of the bone is a large epi- phyfis entirely cartilaginous, in the ante- rior part of which is a femicircular or figmoide cavity, fuited to the trochlea ofi- Jis humeri ^ f The top of it is called the olecranojt, g. the anterior end of its curve is the coronide procefs, h. but that pro- cefs, which in adults makes the comer of the elbow on its hinder part, is not now formed. The radius , which is fltuated on the Radius. fide of the lafl: defcribed bone, has on its fuperior extremity a round epiphyfis , called its head, fig. 13. a. the top of which is hollowed for the reception of the tubercle of the epiphyfis ofjis humeri , on which it turns. Below this epiphyfis is the neck, b. at the bottom of which is a confiderable protuberating procefs, c. in which the flexor cubiti is inferted, which at birth is narrower than in a- Qj* duits, 24. Human Osteogeny. civil ts, and the bone at that place is more bent. Below this procefs the bone is round and {lender down to its middle, d. where it begins and continues gradually to in- creafe in breadth and thicknefs down- ward, until it ends in a cartilaginous e- piphyfis , e. the figure of which is, as well as the part of the bone that joins to it, at birth, a pentagon, one fide of which is large, two about half as big , and two very fmall ones ; in one of the fmall fides is a cavity for the reception of the ulna. At the bottom of this epiphyfis is an oblong, and now very fhallow cavity, divided in its middle, in which are re- ceived two carpal bones, called ficaphoi- des and lunar e , f The ofiifications of the radius and ulna begin about one month after con- ception in the fame maimer as the os humeri does. About three months their extremi- ties have very nearly the fame fhape of full grown ones, fig. 1 8. About four months they differ not in any thing remarkably, but lize, from thofe of nine, fig. 20. a.b, The Lecture IL 125 The laft part of this extremity is the hand, which is form’d by three forts of bones, thofe of the carpus , metacarpus , and fingers. The places of the eight bones of the ojja carpi, carpus are at birth wholly filled with cartilages, which have much the fame fhape the bones ufuallyhave when they are perfectly generated,^. 21. 1, 2, 3, 4> 7j 8* These eight cartilages are never u- nited in one, as * Kerckringius % reports, but are always generated diflintd, and have the fame articulations they have at birth, when they are fo fmall as not to be perceived without the help of a glafs. The of fa metacarpi are four Ion ctojameta- bones, which have cartilaginous epiphy- fes , the largeft of which, Jig. 21. a. ar- ticulate with the carpal bones, the other, c. with the fingers ; the bones, b. are fmooth, and a little moreftraight than in adults. Each of the fingers and thumb con- J° n ^ g ° e f rs lift of three bones, jig. 21. d. e.f the fi- gures of which differ not remarkably from adults. They all have, at the ex- * Ofteog. feet. cap. xviii. tremities ... * 12 6 Human Osteogeny. tremities next the wrift, an epiphyjls at birth wholly cartilaginous. At the other ends of the firfl: bones of each fin- ger and thumb, there are confiderable cartilages, which have been generally thought to be epiphyfes , but, by prepa- rations a little older, they appear not to have offifications within them, as all e- piphyfes have, but are gradually fpread out until they become only of a thick- nefs neceffary for the articulations. The bones of the metacarpus begin, like the ‘other cylindrical bones, to ofii- fyin the form of a ring round their mid- dle, about two months after conception. About four months they differ not much in their fhape or quantity of bone, in proportion to their fize, from full grown foetal ones, jig. 20. d. The fingers and thumb begin to off fify in the fame manner as the metacar- pal bones, but a little later. The firfl: andlecond phalanges are a little ofiified rather before three months after con- ception, but the laft is not until four months, e.fg. About five months they are all fo much ofiified, as not to differ from full grown Lecture II. 127 grown foetal ones in any thing but mag- nitude. W e now come to examine the infe~ rior extremities, each of which are di- vided into three parts, the thigh, leg, and foot. The thigh conlifts of a long bone, Os femoris, plate v\. fig. 1. a. a. with one large epi- phyfis at its inferior extremity, b. b. and three at its liiperior, c.d.e. which, at the time of birth, are united in one earth lage. The upper and larged; of the fupe- rior epiphyfies is called the head of the thigh bone, c. which is like a large por- tion of a globe, and is always at birth wholly cartilaginous. Pretty near the middle of its convexity, there is a cavi- 'A ty, in which is dxt the ligameittum teres , fig- 8. d. Round the balls of the head there is a ridge with a fmall cavity un- der it, in which the inner coat of the capfular ligament of the joint is nxt. The fuperior part of the procels, commonly called the neck of the os fie - moris , is formed by the part of the car- tilage, which runs from the upper part of the balls of the head to the great tro - chanter , H uman Osteogeny. chanter , and makes the bottom of the hollow between them, fig. i . f. The in- ferior part of the neck is now formed moftly by the top of the body of the bone, g. The neck now is much fhort- er than in an adult, and thicker in pro- portion to the lize of the thigh. The next fuperior epiphyfis in fize, is called the great trochanter , e. which is joined, as has been hinted, to the head by the cartilage that forms the fu- perior part of the neck. It is broad at bottom, and ends at top in an obtufe an- gle. The convex or external lide is pret- ty fmooth, not having fuch imprefiions in it as ufually are in adults ; but the large cavity on the external fide, in which is received the tendon of th z glut cats ?ni- nimus , is as deep, in proportion to the bignefs of the part, but not fo wide, as it is at maturity. Just under the pofterior and infe- rior part of the balls of the neck is fitu- ated the third and fmalleft of thefe epi- phyfes , called the little trochanter , d. It is formed by the continuation of the car- tilage down from the neck. It riles from the furface of the bone almoft in the Lecture II. 120 the fhape of a cone. It is now much rounder, and ends more acute, than in adults. O n that part of the cartilage, which is between the little trochanter and the cartilaginous part of the neck, there are many holes much like thofe, which are vihble in the fame place in adults. The inferior epiphyfis of the thigh bone, b.b. differs in fhape very little from the adult. Its condyles , h. h. are much the fame, but the diftance between them is fomewhat greater, i. At the bottom of the cavity between them there are many little holes, and on the inner fide of each condyle , there is now the femilu- nar impreffion. It has an oflification in its middle, fig. 8. g. The bone to which thefe defcribed epiphyfies are joined, is long, and curved a little backward, but not fo much as in adults. From the trochanters down almoft to the middle of the bone it gra- dually leffens, and grows round; then it gradually increafes in width, and grows near its extremity convex on the anteri- or fide, and flat on the pofterior. In the fore part, near to its conjunction with R the o Human Osteogeny. the inferior epiphyfis , there is a fmall ca- vity for the upper part of the patella to play in, which after birth confiderably increafes. In the place of the great ridge, called lima afpera ojfis femoris , there is but a very fmall riling and roughnefs ; but moft of the other protuberances, u- fually obfervable on adult thigh bones, are not vilible. The thigh bone begins to oflify in the fame manner, as I have mentioned of the os humeri , about a month after conception, and then all its epiphyfies , except the little trochanter , are formed in their proper fhape. About three months, the YixAttrochan- ter appears, which then, together with the head, neck, and great trochanter , are all contained in one infeparable cartilage, which reaches a little below the fmall trochanter, fig. 5. At four months,, the bone and all its parts have nearly the fame fhape it has at nine, tho its neck is entirely cartilagi- nous, and continues fo until about eight months,^. 4. Between eight and nine months, the edification begins in its inferior epi- Lecture II. j gx phyfis about its middle, plate vi. fig. i x, and gradually increales in the manner I fhewed you in the firfl: lecture. This is the firfl: epiphyfis that oflifles in the body. The fecond diviflon of this extre- mity, called the leg, confifts of three bones, the patella , tibia^ and fibula. T h e patella^ which is a fmall round- Patella. ifh bone, almoft flat on its external flde, and convex next the articulation, is at birth altogether cartilaginous, plate vi. fig. 2. a. It is joined to the tibia by a ftrong ligament, which penetrates into, the fubftance of its inferior rim, b. and into the tibia a little below its fuperior epiphyfis , c. The texture and infertions of which ligament are moft vifible in fieetuses. The patella is formed as loon as any other part of the leg, and in much the : lame fliape it has at birth. The tibia is a long bone, with a con- Tibia - fiderable epiphyfis at each end. The fuperior, fig. 2. d. which is cartilaginous, except about its center, where there is a fmall oflification like that in the lower epiphyfis of the thigh bone, fig. S.f. has R 2 two 132 Human Osteogeny. two condyles , the external of which is much lefs at birth than the internal, tho in adults the contrary is generally found. The top of this epiphyfis is divided by the protuberance, to which the liga- ments are attached, into two furfaces nearly horizontal ; thefe in adults are both a little concave, but in full grown foetuses the external one is a little con- vex. On thefe furfaces are placed the femilunar cartilages, by which the con- vexity of the epiphyfis is enlarged. In thefe cartilages I don’t find any remark- able difference from adults. The anterior fide of the epiphyfis is fmooth, and full of fmall holes. That part, which has been called the fpine, and fuppofed to be defigned for the in- fertion of the ftrong ligament of the pa- tella, and alfo taken for an epiphyfis , is at birth only a cartilaginous continua- tion of the great epiphyfis , which ends juft above the infertion of that liga- ment. The inferior epiphyfis of the fhin bone is not near lb large as the fuperior, fig. 2. e. On the external fide of it is the longitudinal depreftion, in w 7 hich is re- ceived Lecture II. i ceived the upper part of the inferior epi- phyjis of th z fibula, which cavity is al- moft as large as in adults, f O n the infide of this epiphyjis is the cartilaginous apophyjis , g. which forms the inner ankle, the end of which is much more fharp than in an adult. T he fmall fojfa , in which the tendon of the mufculus tibialis anticus is lodged, may now be feen. The bottom of this epiphyjis ends in a fquare cavity, the fides of which are not now near fo high as in an adult. The greatefl part of the bone of the tibia is triangular. From the infertion of the ligamentum patellce , down near three fourths of its length, jig. 2. c. h. there is a fharp ridge, which toward the bottom of the bone gradually leffens, very like what is feen in adults. The back part of the bone is fmoother, the lateral edges rounder, and the hollow at the bottom of the external fide for the reception of a fmall part of the inferior extremity of the fibula^ is much lefsthan at maturity. The fbula is at birth ftraigh ter than in Fibula. an adult, jig. 2. i. and at top lefs round : the en on 4. HumanOsteogeny. the greateft part of it is flat, and part of its anterior edge much fharper than the pofterior, where in adults it is irregular- ly triangular. At its fuperior extremity there is an epiphyfis , k. the top of which Hants off, and forms almoft a point, where in adults there is a broad edge. A t the inferior end there is a larger epiphyfis, by which is formed the exter- nal ankle, /. It is narrower and longer, in proportion to the fize of the whole bone, than in adults. It now has the linuolity on its back part for the tendons of the mufculi peronei. Both the tibia and fibula begin to oiTify in the fame manner, and about the fame time, as the thigh bone does, and alfo gradually increafe in the fame manner, and much in the fame propor- tion. The fuperior epiphyfis of the tibia does not begin to ollify until near nine months, and is the fecond epiphyfis that edifies. The laft part of the lower extremi- ty of the skeleton is ufually divided in- tq three parts, the bones of the tarfus x iwtctr Lecture XL metatarfus , and toes, to which mull be added the ojj'a fiefiamoidea. The bones ot the tarfus are feven in ojfa tarfi. number, fig . 3. The places of the five fmalleft of thefe are always entirely at birth fupplied with cartilages of much the fame figure of thofe in adults ; 3,4, 5, 6, 7. but the two largeft, 1, 2. which are the afiragalus and os calcis , have a large offification within each of them, fig. 14, 15. which begins in the os calcis about four months, fig. 4. d. but in the afiragalus not until five or fix after con- ception. All thefe bones are generated di- ftindt, and articulated in the fame man- ner as they are at birth, as foon as they are generated. The ojj'a metatar fit , which are five in °JF a meta ' number, have at each end of them epi- phyfies wholly cartilaginous, fig. 3. a. b. and the bodies, which are long bones, c. have not any very remarkable difference from the adult. Between two and three months af- ter conception, thefe bones begin to of- fify in the fame manner as the larger cylindrical bones do. The 13 6 Human Osteogeny. Bones^of The bones of the toes have, at birth, like thofe of the fingers, cartilaginous epiphyfes at each of their ends next the met at arfal bones, fig. 3. e.d. The great- eft part of the laft bone of all the fmall toes is cartilaginous, f These bones begin to be generated much about the fame time, and much in the fame manner, as thofe of the fin- gers, except the laft phalanx of the fmall toes. ojja fe/a- T h e only parts of a foetal skeleton, which remain to be taken notice of, are the ojfa fefamoidea , which all the wri- ters, I have met with on this fubjedt, have wholly pafled over unobferved. The number of them in foetuses are, as in a- dults, very different in different fdbjecfts. Thofe, which are the moft conftandy found, are two in the bottom of the foot, £xt in the ligament of the articula- tion of the firft bone of each great toe, with its os metatarfi. In all foetuses , from three months after conception to birth, the places of thefe ojfa fefaimidea are always filled with cartilages of near- ly the fame fhape thofe fefamotde bones ufually have, when they are arrived at Lecture II. 137 perfect maturity, plate iv.y^r. 1 8. a. a,, jig. 1 9. a. a. In one fubjedt at birth I found, in each of the fefamoide bones of one foot, a very fmail point of ofllfica- tion. In like manner thofe ojfa fefamoidea l which are fometimes found at the be- ginning of the mufculi gajlrocnemii , are to be feen in foetuses. By the defcriptions I have now giv- en of all the different parts of foetal ske- letons, it manifeftly appears, that there is not one fingle bone, except the teeth, or one epiphyfs in an adult skeleton, which is not to be found in a full grown foetus , or in its place a cartilage of nearly the fame fhape : confequently, the account cannot be right, which the ingenious profeffor * Monro gives of the ojfa fefa- moidea being “ nothing elfe than the “ ligaments of the articulations, or the £t firm tendons of flrong mufcles, or “ both, become bony by the violent com- “ preflion they fuffer in the fituation * £ they are.” * Anat. of the bones, Edjn. 1726. p. 337. 8 EXPLI-, [ i39 1 T H E EXPLICATION O F T H E PLATES. Plate I. Figure i. epresents theskull of a foetus of nine months in its natural fize. a. a. The two frontal bones. b. The fontahella. c. The fuperciliary ridge. d. The hole for the opthalmic branch of the fifth pair of nerves. e. The orbital proceis of that frontal bone. f The os par iet ale. g . The anterior and inferior end of that bone which reaches over the tem- poral procefs of the fphenoide bone. S2 h. The 140 The Explication b. The os fquamofum. i. Its zygomatic procels. k. Part of the petrofum. /. T he temporal procefs of the fphenoide bone, in the opening over which are three fmall ojfa Wormiana . m. Os nafi. n. Os imguis. 0. Os males. p. Os maxillare fuperius. q. Its nafal procefs. r. Its orbital procefs. s. The hole called orbiter ext emus. Fig. 2. Reprefents the bottom of the skull of a large full grown foetus. a. a. The palate proceffes of the off a maxillaria fuperiora. b. A future that runs crols the anterior part of the palate. l, 2, 3, 4, 5. The cavities in which the teeth in their bags are contained. 6. The hinder part of the vomer. c. c. - Off a palati. d. The pterygoids procefs of the fphe~ noide bone. e. The hook of its inner ala. f. Part of the Plates. i f. Part of the body of the fphenoide bone. g. Part of the os parietale . h. The fi fibre, thro which pafles that branch of the fifth pair of nerves, called chorda tympani. 7. The zygomatic procefsof the os fqua~ mofurn. 7. The fame named procefs of the os malce. k . The cartilage at the end of the os petrofum. l . Thatpartof the os petrofum on which afterwards grows the mafoide pro- cefs. m. The triangular or firfi: bone of the occiput. n. 7 i. The cartilages which join the fe- cond and third bone of the occiput to the firfi:. p. p. The fecond and third bones of the occiput. q. The fourth bone. r. r. The cartilages, which join the three firfi: of the occipital bones and the hinder part of the os petrofum together. 1. s. Two ojjfa triquetra , v. The The Explication v. The entrance of the carotide artery into the os petrofum. w. Its exit out of the fame bone. x. The entrance of the tuba Eufiachia- na into the anterior part of the ca- vitas tympani . y. z. The two ends of the bone called annulare or annulus. Fig. 3. Reprefents an os frontis of a foe- tus of four months after conception* a little magnified, the better to fhew its texture. Fig. 4. Is an os frontis of a foetus be- tween two and three months. Fig. 5. An os parietale of a foetus of fix months, or a little more. f The rifing in its middle, perfectly fmooth, from whence the fibres feem to fhoot like radii. Fig. 6. An os parietale of a foetus of four months, a little magnified, as fig- 3 - Fg. 7. Another of a foetus of two months. of the Plate s. 143 Fig. 8. Reprefents the infide of the firft bone of a full grown foetal oc- ciput. m. The flit at its fuperior angle. n. n. The notches or flits at the lateral angles. q. A groove from the bottom of the upper flit to the middle of the bone. Fig. 9 . Reprefents the infide of the fe- cond, third, and fourth bones of the occiput. n . n. The cartilages at the hinder ends of the fecond and third bones, by which they join the firft bone. p. p. The fecond and third bones of the occiput. q. The fourth bone. r. r. The cartilages at the anterior ends of the fecond and third bones, by which they join the fourth bone. s. The cartilage, which joins the fourth bone to the body of the fphenoide bone. Fig. 1 o . The external fide of the four bones of the occiput of a fcetm of four months, F'g- 1 1 ? 144. ri° e Explication Fig. 11. The infide of the firft bone of the occiput of a foetus a little under three months. a. The bony incruftation on its inferior part. b. Its fuperior or reticular part. Fig. 1 2. Reprefents an external view of an os temporis of a full grown foetus. h. The os fquamofum. i. The root of the zygomatic procels. /. The hinder part of the os petrofum. L The cartilage, which furrounds the hinder end of the petrofum . m. The membrane, which covers the membrana tympani peculiar to the n. The membrana tympani. 0 . 0 . 0. The annulus. Fig . 13- Is a view of the infide of the os temporis. h. The os fqua 7 nofum. 1. i. The ridge by which the fquamofum is joined to the petrofum. 1 . A fmall hole generally to be feen in foetuses , and feldom, if ever, in. adults, m . The of the Plates. 145 m. The ridge, made by the fuperior fe- micircular canal. n. The large hole under that ridge. 0. The meatus auditorius interims. p. The fharp ridge, which runs from the fuperior femicircular canal to the end of the bone. q. The cavity for the Jinus lateralis du- ra matris. r. A fmall hole, amidft feveral lefs, on- ly to be feen in a foetus. s. The opening of the canalis Fallopii. Fig. 14. The inferior external fide of the os petrofum of a full grown foe- tus. a. The ftyloide epiphyfis. b. The hole called aqucedu&us Fallopii . c. A fmall and very fharp procefs, ge- nerally deftroyed by cleaning the bone. d. The beginning of the paiiage of the . carotide artery. The ending of that pafiage. P L AT E T 14.6 The Explication Plate II. Fig. i. Reprefents the temporal bone of a foetus of fix months. a. The beginning of the tuba Eujla- chiana. b. The hinder part of the os petrofutn partly cartilaginous. Fig. 2. The os temporis of a foetus of four months. a. The os fquatnofum. b. b. The os petrofuni , almoft wholly cartilaginous. d, The flyloide epiphyfs. Fig. 3. A view of the inner fide of the ospetrofum of a foetus of four months. Fig. 4. The fame as fgui~e 3. flit. Fig. 5. The os fquamofum of a foetus of four months. Fig. 6. The fame bone of & foetus of three months. Fig. 7. Reprefents a view of the cavitas tympani of a full grown foetus , with the bones of the ear in their natu- ral fltuation. The of the Plates. i^j a. The long and flender procefs of the malleus in its natural lituation. b. The connexion of the heads of the malleus and incus. c. The foramen rotundum. Fig. 8 . Reprefents the inner fide of the os fquamofum of a full grown fee- tus , with the annulus , malleus , and incus ^ and a fmall part of the os pe- trofum. a. The infide of the membrana tympanu i.i. The ridge by which the os fquamo- fum is joined to the petrofum. l . A fmall hole peculiar to foetuses. m. The part of the os fquamofum y which makes the upper and external fide of the tympanum^ in which are fmall cancelli. Fig. 9. Reprefents the os petrofum of a foetus of feven months, in which appears the cavitas tympanic with- out the fmall bones. a. The foramen ovale* b. The foramen rotundum. k. The cartilage at the end of die pe~ trofum. T 2 Fig. 10. 148 The Explication Fig. i o. Reprefents the cochlea a and the three femicircular canals, b . c. d. Fig. 1 1. The os petrofum of a foetus of feven months, flit. Fig. 12. The cs annulare , or annulus , of a full grown foetus. Fig. 1 3. The fame bone of a foetus of feven months. Fig. 14. The fame of three months. 'ig. 15. The malleus . a. Its long procefs. b. Its handle. c. Its little procefs, a. Its head. Fig. 16. The malleus flit. Fig. 1 7. The incus. a. Its fhort leg. b. Its long leg. c. The os orbicular e. d. The head of the incus. Fig. 1 8. The incus flit. Fig. 19. of the Plates. ‘Fig. 19. The ftapes. a. a. Its legs. b. Its bahs. c. Its head. Fig. 20. A view of the internal hde of the fphenoide bone of a full grown e b. b. Its great wings. c . The cartilage by which it joins the fourth bone of the occiput. d. d. The pofterior clinoide procefles, en- tirely cartilaginous. e. The fella Turcica. f. f The anterior clinoide procefles, wholly bone. g. g. The little wings. h. The notch in which part of the crif- ta galli is received. i. i. The lateral procefles of the body of the fphenoide bone, to which the great wings are hxt. Fig. 2 1. A view of the external fide of fig . 20. (t. The body of the fphenoide bone. b. b. Its great wings. f. The cartilage at the end of the bo- The Ex PLICA TIOM d- Its azygos procefs. e. The temporal procefs of the great wing. f The orbital procefs. g.g. The little wings. Fig . 22. Is a great wing of the fphe- noide bone of a foetus of fix months. Fig. 23. The inner fide of the body of the fphenoide bone of the fame foe- tus as fig. 2 2. c. The cartilage next the occiput. d. d. The pofterior clinoide proceffes, cartilaginous. e. The fella Furcica , moflly bone. f. f. The anterior clinoide proceffes, car- tilaginous. g. g. The little wings, wholly offihed, except at h. i. i. The lateral proceffes. Fig. 25. Reprefents the body with the little wings of the fphenoide bone, together with the fecond, third, and fourth parts of the occiput of a foe- tus oi three months, but little oflified. a.h. c. Small points of offification in the body and little wings of th zfphe- nojde. Fig. 26. of the Plates. i ^ i Fig. 2 6 . Is part of the os ethmoides car- tilaginous, and the vomer bony. a. The feptum nafi. b. The crifla galln c. One fide of the vomer. d. The bottom of the vomer , by which itjoins the offa maxillaria fuperiora> and the offa palati. Fig. 27. Reprefents the fame parts as the laft of a foetus of a little more than four months. Fig. 2 8 . Reprefents one of the external fides of the nares. a.b.b. The off a fpo?tgiofa fuperiora. c. The inlide of the os ttufi. d. The os fpongiofum infer ius. e. Part of the os maxillare fuperius . Fig. 29. Reprefents the os planum b. with a cartilage, a. a. a. furrounding the greateft part of it. 30, 31. The offa fpongiofa of a foetus of fix months. Plate x C2 The Explication Plate III. Fig. i. Reprefents the infide of the os unguis of a full grown foetus. Fig. 2. The external fide of the os ?na~ Ice of the fame age. Fig. 3. The internal fide of the os ma - Ice of a foetus of four months. Fig. 4. Reprefents the external fide of an os maxillare fuperius and os pa- lati of a full grown foetus. a. The nafalprocefs of the os maxillare. b. Its orbital procefs. c . The cavity in which part of the os malce is fixt. d. Theorbital procefs of the palate bone. Fig. 5. The fide next the nares of the os 7 naxillare fuperius and os palati. a . The infide of the nafal procefs of the upper jaw bone. b. The pafiage of the iachrimal dud: into the nares. f. The procefs by which this bone is conne&ed to its fellow on the other fide- Fart of the Plates. ii e. e. e. Parts of the fide and bottom of the nares, formed by this jaw-bone. d. The antrum Highmorianum . f The orbital procefs of the pal ate bone. g. That part of the os palati , which makes the hinder part of the fide of the nares. h. The end of the lamella of the max- illary bone, under which Hides part of the os palati. 6. Reprefents the os palati of a full grown foetus. a. The procefs, which joins the procels of the fphenoide bone. b. The procels, which runs under the thin lamella , on the palate part of the upper jaw-bone. c. The nafal procefs. d. The orbital procels. Fig. 7. The os maxillare fuperius of a foetus of four months. Fig. 8. The os palati of a foetus of the fame age. Fig. 9. The under jaw of a full grown foetus . U a. a. Its cn ic/j. The Explication a. a. Its two parts. b. Their connexions together by liga- ments. c. c. The condyloide procefles. d. d. The coronoide proceffes. i, 2, 3, 4, 5. The cavities for the teeth. Fig. 10. A view of the infide of an under jaw-bone of a foetus of fix months. Fig. 11. The fame of a foetus of three months. a. The bottom of the cavities of the molar es. d. The coronide proeels. Fig. 1 2. The fame bone of foetus of four months. a. The inner lide of the bone in part only generated. Fig. 13. The gums and teeth-bags of a full grown foetus , as they appear when pulled out of the jaw. a. a. a. The gums. b. b.b.b.b.b. The bags containing the teeth. Fig. I 4 > of the Plates. 1^5 Fig. 14, 1 5, 1 6, 17. The bony fhells of the teeth, which are contained in the bags at birth. Fig. 18. The gums and teeth-bags of a foetus of five months. Fig. 19. What is formed of the teeth at five months. Fig. 20. The os hyoides of a full grown foetus . a. a. Its horns. b. Its body. c. c. The connexions or articulations of its horns to its body. Fig. 2 1. The fame flit. a. a. The long oflifications in the horns. b. The oflification in the body. 22. An os hyoides of a eight months. a. An oflification in its body. Fig. 23. An os hyoides of a foetus of four months. Fig. 24. The flernum and cartilaginous parts of the true ribs of a full grown foetus. U 2 a. The i sl 6 The Ex pli cation a. The articulation of the fuperior part of the fternum . b. b.b.b. The articulations of the carti- laginous ends of the ribs, 2, 3,4, 5, c. The connexions of the fame ends of the two inferior true ribs, 6, 7. on the fternum. d. The proceffus enftformis . Fig. 25. Another fternum of a foetus of the fame age as the laft, together with the cartilaginous ends, and a fmall part of the bones of the ribs flit, and part of the clavicle flit. a. a. a. a. The ends of the bony parts of the true ribs. b. Paitof the clavicle. c. Its articulation with the top of the fternum. d. The proceffus eififormis. 1, 2,3,4, 5,6, 7, 8. Oflifications in the fternum of different magnitudes. Fig. 26. The fternum of a foetus of fix or feven months. i, 2, 3, 4, Ofiiffcationsof different mag- nitudes. d. The proceffus enffonnis. Fig. 27 * of the Plates. 157 Fig. 27. A filer num of a foetus of four months. pig. 28. fig. 29. jig. 30. The bony parts of three true ribs of a full grown Fig- 3 L fig' 3 2 - fig- 33- The fehe ribs of the fame age. a. a. a. Their cartilaginous ends. pig. 34. jig. 35. The bony parts of two true ribs of a foetus of three months. pig. 36. fig. 37. Two falfe ribs of the fame age. Plate IV. Figure 1. Reprefents the anterior view of a full grown foetal fpine with thirty-four parts, which are num- bered. Fig. 2. The firft vertebra , call’d Atlas. a. a. Its lateral bones. h. b. The cavities which receive the condyloide procefies of the occiput . c. c, The tranfverfe procefies. do The i^8 The Explication d. The arched cartilage, by which the hinder ends of the lateral bones are connected together. Fig. 3. The fecond vertebra-, call’d den- tata . a. a. Its lateral bones. b. Its tooth-like procefs, from whence it has its name. c . Its body. d. The cartilage in the place of the fpinal procefs, which is not forked like moft of the other vertebra of the neck. Fig. 4. The laft vertebra of the neck. a. a. Its lateral bones. b . Its body. c. Co The bony parts of its tranfverfe proceffes. d. The cartilage, in the place of the fpinal proceis, which is not forked. e. e. The hinder and cartilaginous parts of its tranfverfe proceffes. Fig. 5. A vertebra of the back. a. a. Its lateral bones, b. Its body. c , c. Its of the Plates. 159 c. c. Its tranfverfe proceffes. d. The cartilage in the place of the fpinal procefs, Fig. 6. A vertebra of the loins. a . a. Its lateral bones. b. Its body. c. c. Its tranfverfe procefles, d. The cartilage, in the place of the Ipinal procefs, which is continued round the end of the lateral bones // e. The oblique procelles. Fig. 7. A view of the back of a fpine of a foetus of feven months, which has exactly the fame fhape as a full grown foetal one, and is, in propor- tion to its fize, as much ofiified. The fuperior feven numbers are the vertebrce colli . The next twelve are the vertebrce dorfe. The five numbers lower are the verte- brce lumbales. The next five are the parts of the os fa- crum . The inferior four are the parts of the os coccygis . Fig. 8. 160 The Explication Fig. 8. A large full grown foetal fpine flit. Fig. 9. The firfl vertebra of the neck flit. Fig . 10. Part of a full grown foetal fpine flit, to fhew the bone a. flipt out of the cartilaginous cavity b . in which it was generated and con- tained. Fig. 1 1. The whole bony part of the body of a vertebra of the back. Fig. 11.* Part of a like bone to the for- mer flit. Fig. 12. The fpine of a foetus of three months flit, in which a gradation of ofTification may be feen. Plate V. Fig. 1. Reprefents the os inncnmatum of a full grown foetus, a. Os ilium. b. Os pubis. c. Os ifchium. H The rtf the Plates. 161 d. d. The cartilaginous rim of the ilium. e. The cartilage which joins the Ilium to the top of the acetabulum, f The cartilage which joins the os pu- bis and ifchium together, and forms the inferior lide of the foramen i- magnum. The acetabulum. Fig. 2. An os innominatum flit. Fig. 3. The os innominatum of a foetus of three months. Fig. 4. Another of a foetus of four months. a. A fmall ofiihcation in the ifchium. Fig. 5. The clavicle of a full grown foe- tus. Fig. 6. Another of & foetus of four months. Fig. 7. Another of three months. Fig. 8. A fcapula of a full grown foetus. a. a. a. The balls of the fcapula, fur- rounded by the cartilage b.c.d. b. The inferior or large angle of the fcapula . X c. The 162 The Explication c . The angle at the end of the fpine of the fcapula. d. The fuperior or fmall angle. e. e. The fpine. f The inferior cojla. g. The fuperior cofta. h. The procefs called acromion* i. The coracoide procefs. k. k. The head of the fcapula. l . The glenoide cavity in the head. Fig. 9. The fcapida of a foetus of three months. Fig. 1 o. The fcapida of a foetus of four months. Fig. 11. The os humeri of a full grown a.b. The body of the humerus. c. The cavity at the inferior end of the humerus , in which is received the procefs of the u/na, call’d olecranon . e. The inferior epiphyfisoi the os humeri. d. The fuperior epiphyfis , call’d the head of the humerus. Fig. 12. The ulna of a full grown foe- tus. a.b. The of the Plates. i 6 a. b. The body of the ulna. c. Its inferior epiphyfis. d. The jlyloide procefs of the inferior epiphyfis. e. The fuperior epiphyfis. fi The femicircular cavity of this epi- phyfis > which is adapted to the tro- chlea ofiis humeri . g. The olecranon. h. The conoide procefs. Fig. 1 3. The radius of a full grown foe-- tus. a. The fuperior epiphyfis. b. The neck of the radius. c. The procefs at the bottom of the neck. d. The part at which the bone begins to widen, and fo continues gradual- ly to do, until it ends in the inferi- or epiphyfis e. fi. The cavity at the bottom of the in- ferior epiphyfis f Fig. 14. The os humeri of a full grown foetus flit, to fhew the difference of fubftance at its extremities a. a. from that at its middle b H X 2 F‘g • is- 1 64 . The Expli cation Fig. 15. The ulna of a fcetus between five and fix months, flit. Fig. 1 6. The radius of the fame foetus flit. Fig. 1 7. The os humeri of a foetus of three months. Fig. 18. The radius and ulna of the fame fcetus. Fig. 19. The os hwneri of a foetus of four months. Fig. 20. Reprefents the bones of the fore-arm and hand of the fame foe- tus in their natural fituation. a. The ulna. b. The radius. c. The off a carpi. d. A metacarpal bone. e. The firfi: bone of a finger. f The fecond bone. g. The third bone. Fig. 21. Reprefents the bones of the hand of a full grown foetus in their natural fituation. h 2 , 3 j of the Plates. i 65 1,2,3, 4> 5> 6 > 7. 8 - The # car fi- 1 5* The afiragalus of a full grown foetus flit. Fig. 16, The afiragalus of a foetus of feven months flit. Fig. 1 7. The cartilage of an afiragalus , which had been macerated in wa- ter, flit, in order to fhew the Y man- ner ijo The Ex plic ation , & c . ner in which the bone a. flips out of the cartilaginous cavity b. Fig. 1 8. The bones of the great toe of a full grown foetus flit, with part of the ligament of the joint at the bottom of the firft bone, in which are contained two ojfa fefamoidea . , a. a . Fig. 1 9. The fame bones as fg. 1 8. of a foetus of fix months, with the ojfa fefamoidea . , a. a. F T N 1 S. CORRIGENDA. P AGE 9. line 26. for its read their. /. 12. 1 . 2. r. mem- branes which cover it. p. 54. /. 24. for i. i. r. r. r. p. 59. /. 1 ©. dele f. p. 64. /. 13. dele fig. p. 67. /. 9. for of the bone r. of it, p. 92. /. 12. for i. r. h. p. ICO. /. 26. r. apparet p . 103. /. 11. dele at birth. /. 26. dele b. p. 104. /. 6. for e. e. r. b.b. p. 105. I.12. dele fetal, p. 1 16. /. 9 for e. r. c. p. 1 23. /. 1 4. for coronide r. conoide. p. 139. / 8. r. the hole for a twig of. p. 148 l.\\.for a. r. d, 156, /. 23- r. between fix and feven. p. 167, /. 5. r. epiphyfes. ~ PI. IT. S.jHy'dz Je/ijUifudf PI .IV. vj. mm sshm HWJWi v \? 3 «\ 'f.MyndeJc . ct f.Mynde dele /c . > V ft' r \ - J. \My tide Jc . / m *