Vault LIBRARY OF THE JOHNS HOPKINS UNIVERSITY WILLIAM H. WELCH MEDICA^ LIBRARY RIDOUT COLLECTIdStf^ Drs. John, William G. and John Ri(feut Presented by Mrs. James N. Galloway and Mrs^ Fredprirlf fT 'RicViarrlc 7 I P ^ i 'if Zf.j- -.jr' ‘.-'t? ■3 Digitized by the Internet Archive in 2016 https://archiye.org/details/dralberthallersp21 hall ^ f h . > '“tr ■ ■ * I *< \ 'Vi ■X Dr. Albert Haller’s I f PHYSIOLOGY; BEING A COURSE of LECTURES . f UPON THE Visceral Anatomy and Vital Oeconomy of Human Bodies: INCLUDING The lateft and moft confiderable Discoveries and Improvements, which have been made by the moft eminent Profeffors, through all Parts of Europe, down to the prefent Year. Compiled for the Ufe of the University of Gottin- gen ; now illuftrated with ufeful Remarks ; with an Hijiory of Medicine ; and with a Nofology, or Dodfrine of Difeafes. VOL. II. LONDON: Printed for W. Innys and J. Richardson, in Pater - Nojier Row, M.DCC.LIV, \ 1 . 9 -' DEPOSlTfiO Iff ISSTT. Hist. Hl£i>" VauU CONTENTS O F H E SECOND VOLUME. Lect. XIV. the Senfe of ‘Touch and Feeling. Page I 20 28 36 56 91 I 10 XV. Of the Tajle. XVI. of the Smelling. XVII. Of the Hearing. .XVIII. Of the Sight. XIX. Of the internal Senfes. XX. Of Sleep XXL Of Hunger and Thirjl^ Foods , and Drinks. n 8 XXII. Of Mafication and Saliva. 1 26 XXIII. Of Deglutition. XXIV. Of the Stomach and Di- gejiion, XXV. Of the Omentum. XXVI. OJ the Spleen. XXVII. Of the Liver and Bile. ,XXVIII. Of the Pancreas. XXIX. Of the [mail Inteftines. XXX, Of the Chyliferous Vtjfels. 138 H 7 162 174 1 “ I 205 209 12:^ XXX iv Contents of the Second Volume. Lect. XXXI. Of the large Intejlines. 231 XXXII. Of the Kidneys^ Bladder and Urine. 243 XXXIII. Of the Male Genitals. 261 XXXIV. Of the Virgin Womb. 284 XXXV. Of the B regnant Womb. 297 NOSOLOGY. Lect. I. Of Relaxation. P2ge33i II. Of Rigidity. 343 III. Of Plethora. 351 IV. Of Atrophy or Inanition. 366 V. Of Fevers of all Kinds. 371 VI. Of Fevers eruptive. 398 VII. Of the Meafes and Small-pox. 40 1 ^ VIII. Small-pox in f articular 410 IX. Of Intermittents. 42 8 X. OJ Inflammations. 434 XL Concluflon and Recapitulation, 461 A N Historical Introduction Concerning the ORIGIN and PROGRESS O F PHYSIOLOGY and MEDICINE. §. I. will be readily allowed by the wifer I part of the world, that the trite pla- tonic adage, advifing man to a know- ledge of himfelf Qzavrov) ftrikes more at the prieft and phyfician, than the red; of fo- ciety ; iince the latter is obliged to carry his difquifitions much deeper than the curious painter or ilatuary, even to the innermod: or- ganizations and adlions of each part, as far as armed fenfe and found reafon will condud; him; in order to underftand, or explain, every change and appearance resulting from the body only, or from the body and mind conjuniffcly, whe- ther in a healthy or a difeafed date : ; while the fortiaer, lefs concerned about the organizations of the body, or its mutual connexions with the mind, advances much higher by the fcale of natural and revealed truth, in determining the \Yl. I. 2. : leli- li Progrefs of Phy/iology religious and moral ftate of them both, either for the prefent or the future. Man then, is one divifible effence, compounded of animal body and intelledlual foul j yet fo that his iden- tity or perfonality refides in the laft, as thefupe- rior part, which is however incompleat, with- out a duly difpofed and organifed body, as the medium of all her operations in life. It is enough, that we know fhe is, becaufe fhe ope- rates, thinks, and reafons j and that {he always will be, becaufe {he is immaterial, therefore un- extended, and has no power not to be. As for the operations of the foul, after {lie is feparated from the body by death, they muft be purely intelledlual ; like thofe of angels or fpirits, and confequently fuch as w'e can have no notion of while {he is connected to body, without whofe medium we can naturally have no perceptions, either of ourfelves or of an external w’orld *. §. II. Our body then, in its primitive {fate, is gradually built up, from gelatinous or {limy fluids, {hooting out firft into cob- web-like threads and plains, whereof the moll part are by degrees moulded into two fprings, which like thofe of a watch, we {hall diftingullh into heart and fanguiferous fyllem, as the fufee or main fprings and (2.) the ejiccphalou^ and appended nervous fyflem, as the pendu- [Arillot. i. de part. anim. 5. & Cicero i. Tufc. qureftion.] Anima iit animus, ignifve, nefcio : nec me - ' piidet.nercire quod nefciam. — non videtur, fed ex fundtio- 2 -." -.iTibus dcprehenditur [Apuleius de mundoj : eamque im- . ; ni.'.>rtalem effe, & ab intemu liberani [Plato, io.de re- b’jb.j Morta carcut animra [Ovid. 15. Metam.j lum- and cf Medicine. ill ium-fpring, or regulator. To thefe two fprings there are fubfervient, a fet of correfponding hy- graulic wheels, or intermedia-e fyftematical organs, called vifcera, glands, &c. ferving either to the faculty of nutrition, fenfation, motion, or procreation, in their mod extenlive latitudes: all which are moved or adluated by a fort of endlefs or circular chain of globular and albu- minous juices, intermixed all together in the heart and arteries j thence feparated into vari- ous forts and conliftencies, in different parts, and returned again (fo much as are found of them) into commixture as at firfl: while the morbid or unfound parts are thrown off by cer- tain emundtories or out-lets. And this is the moft contradled or aggregated view that can be had of the human body, at once, confidered as an animated and hygraulic automaton. §. III. It is therefore from the fuperb and fo much admired fabric of our body as the immediate refidence and interpreter of an im- mortal foul, that medicine properly begins to draw the firfl lines of her ample landfcape : for pbyfic has been allowed by the wife men of all ages to begin where philofophy ends ; and they have equally granted, that all the lines of wide philofophy center in him., whofe animal body is both the head and epitome of the whole terraqueous world * j to travel through and graphically defcribe the numberlefs regions of * Unde Porpbyr. devlta Pythag. o avScMTro? ju-of. V. Pfal. vii). 6. & Cicero. - i. de teg.bui. auteri non dicam In hoimm : fed hi cmni cash atque terra rdtioni dlvinitus. a 2 which^ IV Progrefs of Phyfiohgy which, under health and difeafe, is the proper obje(5t of medicine. But here we often carefs and admire the defpicable matter, inftead of the infinitely wife form given to it by the fignet of omnipotency j for if we do but refled: either upon its mucaginous origination, in the firft months of pregnancy, before it has any ability to converfe with the foul, or upon its putrila- ginous diflfolution into an abominable vapour (into which a very few days of fplendant fun, in a hot climate, will wholly convert it, except the fkeleton of bones) after it is thrown off, like a worn-out-garment, from the celeflial inhabitant ; we fhall rather quit the matter for the form, and even make that only a ftep to look up after the adorable fignet, which firft gave the admirable imprefiion. §. IV. Our primitive anceftors, not yet ac- quainted with thofe luxuries and abufes of na- tural benefits, which were afterwards fo much cultivated, and are now fpread to the prejudice of human perfedion throughout the world, lived contentedly on the tender roots and plants, of their own and nature’s tillage, joined with the mealy pulfes or grain of the field, and en- riched by oily and fucculent fruits of the tree and bufli The fimplicity of their archi- * Gen. c. i. V. 29. h Cic. 6 e nat. dcor. & Offic. lib. 1 . terr ^7 gigKUiilur,, ad ujus homir.nm omnia crea- ‘i:ii — Tuvra evim Joeta frugihus^ ts vario leguminum ge- 7urf cuts jnaxima largitate fundi t ea ferarumne an hominujn anf't gignere videtur ? ^lid de vitibus divetijque dicam . — 'C..;:um fide cuffodia, iamque amans deminorum adulatio ? fig id de ksbus quorum ierga ad onus-, cervices ad jugum f iff c. tedure. and of Medicine. V tedlure, both as to cloathing and habitation, equalled that of their diet. A warm fkin wrapped about their wailb and fhoulders, Vv'ith another upon ftubble, for their couch j a natu- ral grot or cavern, fheltered by an agreeable thicket, and bordering upon a refrefhing fpring or rivulet, compleated the. retinue of their ap- parel, and the grandeur of their hotel. They bellowed their pride, envy, and intemperance in labouring the earth, in training their flock, inflru6ling their children, and providing a little dinner or fupper for themfelves and cattle ; which, next to their religious obligations, it was the height of their ambition to fee fafe and found, fleeping round them at night. This ■flmplicity of life made them healthy, and even hardened to a proof, againfl the incle- mencies of air, aliments, and mofl diftempers that now afflidt the puny race of mankind ; but could not fecure them from wounds, bruifes, burns, fradlures, difiocations, and other acci- dents that fo earnefl'y call for chirurgical aid. §. V. Therefore as furgery, out of neceffity, became the earliefl as well as the mofl fenfible part of medicine ; fo anatomy, for the fame reafons, always followed clofe to her heels : and both were obliged to make fome figure in the world, before the fkdl of phyficians could be called to the bar of pradtice. There is no room to doubt, but our firfl fathers were fo wife and void of fuperflition, that if they hap- pened to break a bone, or diflocate a joint, they had a ready recourfe to the next dormitory or tomb, and confulted the figures or connedtions a 3 vi Progrefs of Phy/iohgy of the bones, to relieve themfelves • in the fame manner as pain and neceffity would indantly oblige them to try various fubftances for the re- lief of burns, wounds, &c. For thefe endea- vours for relief, we fee now naturally exerted in every injured perfon, who knows nothing either of phyfic or furgery. The neceffity which de- pendents are under, to confult their fuperiors, for relief in all cafes of diftrefs, made the oldeft patriarchs, priefts, and princes, the wifefc ana- tomifts, no lefs than the ablefl: furgeons and phyficians. Some of thefe, who were oftener called upon for help, invited by a natural curio- lity, no lefs than a defire of being ufeful, and carefifed with the honours or rewards that at- tend on gratuity, doubtlefs took into his cufio- dy the firfi: natural fkeleton, either of man or beaft, that fell in his way, cleanfed by the re- turning dews or rains, and diiledted or dried by the difiTolving rays of the fun. Thus began the earlieft, and the eafieft part of anatom}^, ofteo- logy ; which, with the fituations of the liga- ments, joints, nerves, tendons, and larger ex- ternal blood-veffels, made one of the mofb ufe- *ful and necelfary branches of princely learning ; to be employed in the murdering wars, that ever plagued mankind from the firfi offspring of Adam. Thus the art of healing, as yet chiefiy chirurgical, and railed from repeated pradlices on the vidlims of inclement wars, or unavoidable accidents, was for many }xars ydlodg^d in the hands of a few elders, prieils, k and icl>6ol-men, among the Hebrews andcon- 'g tig nous 'nations of the call j who taught it tra- ditionailv 7 and of Medicine. vii dltionally as a moft ufeful branch of philofo- phy, from the father or mafter to the fon or engaged pupil ['sreTroii^BVf^vivoi ) : from which laft a filial obedience and perpetual gratitude were ever folemnly enjoined and expected ; fince the birth in arts, fciences, and learning, appeared even offuperior value to that of nature. Examples of this are hereafter notable in the munificence of great Alexander, to his pre- ceptor Ariflotle ; in the oath of allegiance pre- fcribed by Hippocrates to his pupils, &c. §. VI. Soon after the flood the art of healing feems to have extended, together with monarchy, near Mefopotamia, under Phoebus kingofAlIy- ria; whence itfpread with arts and languages into iEgypt and Chaldea. For it appears by the chronographical monuments wrote concerning the affairs of iEgypt, by order of king Ptolo- meus Philadelphus, under the care of the learned Manethus, of the facerdotal order, tranfcribed and handed down to us by the trufty Synceilus [of the eighth century, in his Greek hiftory of the dynaflies of the kings of ^gypt, in whofe antiquities he appears greatly to have rivalled both Herodotus and Diodorus Siculus (pag. 54. and 56. cap. 6.] “ That Mercurius, “ firfi: king of the Thebans, among other “ things, wrote hooks or Jkim upon anatomy- \ “ for he was a phyficiani' pe^ovrai fStCXoi avot^ To^iKoci ijv, &c. The fame is alfo confirmed to us by Clemens Alexandrinus, of equal credit, and near fix ages older that iSyn-'^ cellus j who tells us (Stromat. lib. i. p. 634.'b.)l.: “ That out of forty two differ tations left by vlii Frogrefs of Ply fiology “ Mercurlus, fix of them appertained to the “ philofophy of the ^Egyptians ; and the other “ fix related to the art of healing, of which “ the firft was anatomical, upon the confiruBion “ of the h mat body I’ ra kcz- 7 acTJc£U'^?. It is therefore not without reafon, faid by Pliny ( 1 . 29. c. 2.), that the Egyptians claim phyfic as an art invented amongfl them. For this Mercurius flourifhed foon after the death of Noah ,^Gen. ix. 28 ), a whole thoufand years before the ^fculapian inventor of the Greeks (whofe fon Machon, is by Homer (II. B.) mentioned at the fackage of Troy) ; fifteen ages before the times of Hippocrates, and near twenty before the days of Galen. §. Vfl. It is not to be wondered, that Mer- curius ^Egyptiacus fhould have been fo early able to leave feveral volumina or friins upon anatomy in the temple of Memphis ; if we contider the opportunities thofe had of know- ledge in the fubjed, who were often both pa- triarch, prieif, and king, as well as phyfician to their fubjeds. For under thofe charaders, there were many ample fountains laid open to them ; fuch as (i.) the orthotomia, or jufl manner of flaying, cutting, and preparing ani- mals for facrifice, taught bv God to our firft parents, and required by him from their fuc- ceffors, v;ho learned it traditionally before Mo- , /es, and afterwards by praefeript, till at length the -Icruclfixbn of cur Saviour fet the emblem ofiiim MalidegGen'. c. iv. v. 4.). For it is not to be ' fupppfed, but Cain and Abel were fully, in- n ftruded by their father in all points required to and of Medicine. lx a juft adminiftration of facrifice ; otherwife God would not have refufed to take by fire from heaven the offering of the former, for of- fending him by a wilful concupifcence, in not facrificing the beft of his produce ; for which, and malicioufly murdering his brother, as God’s favourite, and a type of our Saviour ; he Cain was cut off from the family of Adam, as a type of the unbelieving Jews, and deftined to be accidentally fhot from Lamech (Gen. iv. 23.}. — (2.) From the fuperftitious andflowly- dreaming infpections of the internal parts of animals facrificed to idols by Gentiles j which was probably a very early corruption made by fome of the defcendants of Noah. — (3.) From the dextrous killing, cutting-up, and difplaying to advantage the feveral parts of large animals, by the art of butchery 3 which foon became a profeffion, after a licence was given by God for men to eat flefla, in the days of Noah (Gen. ix. 4.).— (4.) From the care which all princes and great men took to have their predeceffors accurately embalmed; which muft have been executed with very great exadfnefs, fince we are told (Gen. 1 . 2. and 3.) in the original, that . feveral phyficians were employed- forty days in embalming Jacob Ifrael ; and that this was the ufual time for them to be employed in fuch a work^. — And laftly, (3.) from the frequent and ample wounds that ever befel men, either accidentally or in wars: which laft gave 'even to philofophers very juft notions .-of anatpmy,^' fince the learned Galen himfelf admiresll'and’-'- praifes (de ufu part. 4. 14.) the great know»- ledge ' X Progrefs of Phyfiology ledge and Iklll of the poet Homer, who wrote about nine or ten ages before himfelf, and be- fore chriftianity. See feveral elegant flowers of anatomy in his Iliad. Lib. iv. ver. 517, & feq. Lib, V. ver. 65, & feq — Lib. v. ver. 305, & feq.— Lib. xi, ver. 577.— -Lib. xii. ver. 384. &c. REMARK. * The great recorder of antiquity, Herodotus (Euterpe, cap. 87. & 88.), who wrote his hiftory near five ages before chriftianity, defcribes three methods of embalming in ufe among the .Egypti- ans, of which only one could be of any confiderable fervice to anatomy \ which we fliall therefore de- fcribe, without prefuming to determine whether it be the fame with that praftifed upon Jacob, Jo- feph (Gen. 1 , ver. 2. & 3.-— ib. ver. 25. ult.), and the other patriarchs, or not. “ Firft the diredtor, having laid out the body, and marked how far “ the cutter was to open the left fide •, this laft ex- “ trafted the brain through the noftrils, and cut “ throw the marked fide with an Egyptian pebble : \vhich being eftedled, he immediately “ took to his heels •, becaufe thereupon it was “ buftomary for thofe pirefent to curfe him, and . through ftones alter him. Next came thofe called the curers, falters, and anointers of the body, as they were moft efteemed in their pro- ‘‘ fefiions ; and. now one of thefe extracfed the our.s,' and other vifcera of the body, except the “ liearr. and kidneys, through the incifipn that had --.been made,: after this, another wailaed the ven- . - ^ers with Phoenician wine, charged with per- and then the body, thus wafhed, was i(^?kuf|pf^vely anointed for the fpace of thirty days, Lh'%lfam of the cedar-tree, and other coftly refervatives : next, the. ftomach and guts, “ which and of Medicine. xi “ which had been before extrafled, were Huffed “ with myrrh, caffia-wood, and other perfumes “ (except incenfe or frankincenfe), and then fewed “ up in the body, which they now faked with nitre” [i. e. a fait of the ancients, more lixivial or like pot-afh than our nitre] “ for the fpace of “ feventy days, as the longeft term that the body “ could bear the fait. This time being elapfed, “ the walked body is next rolled up in fine linen “ fwaths, fpread like a plaifter with gums, which “ the ^Egyptians generally ufe inftead of glue. Be- “ ing thus covered to a juft thicknefs, they make “ a hollow image or cafe of wood, correfpond- “ ing to the dead original ; which being thus in- “ clofed, they repofit in fome clofet or cell of a “ chamber,” [or funeral dormitory] “ ftanding “ upright on its feet.” 2. Thus fmall, rude, and natural (n°. i, fu- pra) was the birth of thofe now copious and myfticai profefiions we call anatomy and medi- cine, feen amongft the eariieft offsprings of ne- ceffity ; which latter part, medicine, had its firft rudiments laid by (i.) accident; (2.) in- ftindt, and (3.) promifcuous experiment. — By accident y we mean the difcovery of medicines undelignedly made, like what we are told by M. Geofrey of the celebrated bark j viz. that a number of the trees being blown down into an adjacent lake, gave fuch a bitter tinfture to the water, that no perfons would ufe it, nor any cattle drink it : kill at length an Indian, urged with fevere thirff, in an intermittent fever," ea- gerly took two or three large draughts, which cured his diftemper, and gave fuch reputecto the waters, that they were £bon exHaufted i y.il Progrefs of Phyfiolcgy and when the lake, filled by the next rains, was found without its bitternefs and virtues, it was concluded they both arofe from the mace- rated trees which had been formerly blown into it, as indeed they were foon convinced by expei'imenL — By iuJUna we mean that difcre- tion, which in different degrees is diffufed through all animals, directing them to choofe what is good, and avoid whatever is evil or defirudlive to them ; v/hich faculty is pofTeffed by man in a degree far fuperior to the reft of the animal creation. We fee the fond and familiar beaft we call a dog, having a fenfible membranous ftomach like that of ourfelves, with a much more fharp or corroding faliva and ftomach juice, will naturally endeavour to aihry his hungry pain by the firft (even dry) hone that comes in his way, reducible to the grinding powers of his teeth, and makes it more an abfurbent to acrimony, than a matter of nourilhment ; whence the dry chalky fa:-ces tl'.ence left, called album grsecum. The fame docs the green-ficknefs-girl with flates, chalk, wall, aftrcs, &c. from an offending acid and debility. But if putrid flefh miakes an offend- ing alcaly on the ftomach of dog or cat, they naturally fall to eating of acefcent grafs, &C. in fevers alfo, nature rejedts what is bad, and generally craves for what is falutary to the diftemper.— By promifcuous expeti-nent, we remedies found by hafty or indifcriminate rtf jni)|jh,iiot .pointed out by flow reafon or in- as, c. g. if a peafant cuts or burns his a niuTiber of odd things (that come firft arid of ivdediolne. to hand) are Imnaediate’y applied, and thole which hurt or heal are accordingly remarked. In this way many valuable remedies have been firft found by vulgar hands, that have come af- terwards to a better ufe under the higheil in our profeffion ■, to inflance only in fome late lixivial medicines for the fione or gravel, &c. In this manner, accident, inflind:, and loofe experiment drew fome of the firfl lines of phyfic ; improved afterwards by degrees into a profeffion, like other human arts and fciences. 3. Afterwards phyfic went on improving among the Greeks, in a much more fenfibk way, viz : ( i .) by expofing their fick in the moft public ways and markets obliging pafiiengers to afk about their diftempers, and inform them if they had known any thing ferviceable in the like cafes ; (2;) by appointing certain perfons i chiefly priefts from the temples of Apollo and 7$lfculapius, as the mofi; learned and able), to pradife in the difeafes of fome one part, as the eye, ear, &c. by which fuch gained much wealth and honour to their families, within which they hoarded and cramped up the artj (3.) by writing down privately each their particular . obfervations (n°. i. fupra), philofophical, ana- tomical, or medical ; and by regiftering pub- lickly the principal remedies that had been found ufeful, upon tables in the pillars and i^]grotos faos in publico proponebant, i.t prsbtfreun- - tium quivis, fi quid vel ipfe eodem morbo confl.ifiatuyyeJ ' iimiliter laboranti opitulatus medelas noflbt, id aegcotanti'-.. iigniiicaret. Plutarch, lat. viver.d. - 'b'-' xlv Prog7'efs of Phyfology walls of thofe temples -j', which were peculi- arly dedicated to their phyfical deities, Apollo, and iEfculapius. A fragment of one of thefe Greek tables, ftill preferved at Rome, and pub- iifhed in the collections of Gruterus, runs thus: Lucius being afflicted with a pain in his fide, implored the affiftance of the God iEfcula- plus ; whereupon the oracle directed him “ to go to the altar, to take fome of the aflaes, “ mix them with wine, and apply them to the “ aching-fide : which done, he grew well, and gave thanks to the god, and his health to the fervice of his country.” Wood afhes fteeped in wine would doubtlefs form a fucce- daneum to what we now call opodeltoch ; and be of ufe to rheumatic pains of the fide, or other parts. Sometimes, in cafes of flerility and weaknefs, they were ordered to put a hatchet or fome iron inftrument in the cleft of a recent oak, and take the crocus or ruft formed upon it by the aftringent, fubacid fap, &c. 'Thus the faid temples were a fort of hofpitals, to which the fick repaired for advice j which they here received, either in dreams or by ear, whenever the devil or his priefts thought fit to make their difclofures ; which they often did to the beft of their power, in order to fix thofe honours and worfiiips upon themfelves, which were due only to almighty God. .. . 4 .. Thus went on phyfic, improving in the -/ ‘hands of priefls, and a few Greek philofophers, , Nunc c3ea, nunc fuccurre mihl, nam pofle mederi, docet tempHs, multa tabella tuis. Tibult. lib. l. . which and of Medicine. xv which laft had fchools, chiefly phyfical, at Rhodes, Coos, Cnidos, and Epidaurus, where Pythagoras, Heraclitus, and Democritus were for fome time teachers : but the moft confi- derable of them was the fchool of Cos, in the ifland Coos; where Herodicus, w'ho intro- duced the gymnafia or exercifes into medicine, and his fon, the great Hippocrates ■*, were edu- cated. And this leads us to the birth or fecond aera of phyfic, which now, too perfed: and formi- dable to be any longer confined within the womb of philofophy, loudly called for fome hand to deliver her from the cramping chains and fecret cabinets of feled priefls, philofophers, and to- pical pradifers ; that fhe might come freely abroad as a liberal fdence, to improve know- ledge, andbe improved herfelf, under no other re- ilraints than thofe of invariable truth and com- mon utility. This talk then was referved to the great Hippocrates, from whofe time we date the genuine nativity of phyfic, in all her branches ; from ivhence forw'ard, to the midfl of the laft century, we date her puerile growth * i^lfculapius, quoniam adhuc rudem & vulgarem hanc fcientiam paulo fubtilius excoluit, in deorum numerum receptus eft. Hujus deinde duo filii Podalarius & Ma- chaon Bello Trojano ducem Agamemnonem fequuti non mediocrem opem commilitoribus fuis attulerunt. Homer. II. b. — Deniocriti autem difcipulus, Hippocrates Cous, pri- mus quidem ex omnibus memoria dignis ab ftudio fapien- tias difciplinam hanc feparavic. Celfus in prsf.-^ Hippo- crati honores, quos Herculi, decrevit Graecia. i; Pirn.- . 37. Medicinam quae a rrcjanis temporibus in notle den-,.* \ fillima latuerat, ul'que ad Peloponneliacum belluitj,‘‘revo-'W^/ cavit in lucem ; h inftituit hanc quae Clmicpi vocJatyr.?^"’ Plin. lib. 29. b, I. XVI Progrefs Phyjiology and minority • when our Britifli Hippocrates qualified her to plead rationally and juftly in all her caufes : and being now near the fum- mit of her perfedtion, the prefent pofture of affairs in the medical world, leave me in fome doubt, whether we are not fhortly to expedt her declenfion. §. VIII. The firfl inventor or refiorer of medicine among the Greeks, is faid to have been Apollo ; one of v/hofe fons or fucctfibrs, ^fculapius, came the next to him in honours and repute, for confiderably improving or en- larging the bounds of healing ; which from the time that this laft: great profefTor was killed by a clap of thunder, buffered a fort of extindlion or interregnum for near 500 years; ’till in the reign of the wife Perfian king Artaxerxes, it was again refiored, by the fplendour of Hippo- crates, one of the faid Afclepian or yTfculapian family, in the ifland Coos. [Ifido’ us Hilpalen- fis. Orig. iv. 3. 4.] He renewed the divine ho- nours tributary to his inventive anceftors, Apollo and ^fculapius, by confecrating temples to their fervice, in which the mofi fuccefsful re- medies for difeafes Vv^ere recorded : and when thofe temples were afterwards deftroyed by fire, he with great judgment reduced his colledtions into a liberal fyftem ; and firfi; inflituted the clinical or bed-lide pradlice, that has ever fince been followed, inftead of obliging the fick or ji^ured to repair for help to the temples. [Pli- ,'Mhs fecuhdus, hift. nat. 29. i.] Thusphyfic, Jfi';^|feted by /ipcllo^ and amplified by Mjcula- ifWS was at length perfected among the Greeks, and of Medicine. xvli by their facceffor Hippocrates ; for which he had equally with his anceftors, divine honours paid to his memory, by the paganifm of thofe days and countries : to which Celfus, his Latin imitator, four ages after, juft before Chriftianity, under the emperor Juftus, readily fubfcribes him- felf (in pref. lib. i.) j for that Hippocrates had firft feparated phylic from polymathy, and ge- neroully communicated its precepts, reduced to a plain fyftem, which his anceflors had co'n- cealed or reftrained within their own families 2. Paufanius, the Grecian, who lived after Celfus at Rome, in the fecond age of chriflia- nity, in the tenth book of his defcriptions of Greece ; tells us, that among other prefents to the delphle temple of Apollo, there was kept one, given by Hippocrates, and of a very great antiquity j being the figure of a man in brafs, wafted even to the bones by a confumption. — In this probably might be feen fome of the ear- lieft and jufteft lines of anatomy, as fhe had as yet appeared to the anceftors of Hippocrates. 3. This laft father and glory of medicine, fuch, not only to his learned countrymen; the Greeks, but to all more remote and lefs po- lifhed nations, and even to all diftant ages, fo long as phyfic herfelf fliall fubftft j was defend- ed from the fame name in the phyfical line, from Tpfculapius (n". i. fup.) born an. mundi 3512, in the city of Cos, of the ifland Coos, near the Attic continent j and flourifhed in the adjacent countries, about five ages before, thd" coming of our faviour. Hippocrates, likebtfaer great genuifes,. fet Out even young, in his * V. loc. citat. fub. p. XV. VoL. L b feffion f xviii Progrefs of PhyfioJc^y feffion s and having quickly accomplilhed his ftudies in philology, rhetoric and logic, under Gorglas Leontius j in geometry, aftronomy, and philofophy, under Democritus of Abdera ; and in all the branches of meaicine, under his two great medical anceftors, his grand-father Hippocrates, and his father Heraclides, who v/ere defcended the 14th family, in a right line from the two fons of ySifculapius, Podaii- rius and Machaon, (mentioned as princes by Homer, at the fackage of Troy; and after pro- moted, the former to be king of Caria, in the leffer Afia ; and the latter fovereign of Mefene, included as a peninfula betwixt the Tygris and Euphrates, in the Babilonic part of Afia.). He fpent fome of his days in the academical difci- plination of medical youths, in his native city, where an iEfculapian m-ufaeum had been ereft- ed by his ancefiiors to teach them ; for whom he prefer ibed didaftical aphorifms, before he wrote his fyfiiem, and before the conflagration of the medical temples (n°. i. fup.) ; but the majority of his life was fpent, like that of the other great phyficians and philofophers of thofe times, perpetually itinerant. 4. Although he was archiater to Perdicas king of Macedon, courted and carelTed by all the greateft kings, princes, and philofophers of his day ; yet he always appeared as the grave \^-anLp wore a fort of cowl or ca- if or. the conveniency of travelling, and ■jj^-VlpareS. no labours by land or fea, to relieve J|;|^yf'-pi^d.^|alamities of his country. He always a (Iridt regard for the principles of and of Medicine. xix truth > honour, and the moral mconomy of his wife miftrefs, nature, as gave him a laudable contempt over the wealth, pleafures, and ho- nours of the great 5 which, with his learned works, amicable and humane difpofition to people of all ranks, have left him a glorious memory, untainted with the ufual pagan cor- ruptions. His incefiant travels through all parts of Macedonia, Thrace, and Theffalia, were equally ufefuL to his country, as enter- taining and inftrudlive to himfelfj becaufe he always kept a journal, into which he tranfcribed all adverfaria or obfervations that appeared wor- thy of notice : although this gave occafion for thofe who envied his great character, to fufpedt, and even to fay, that he procured the confla- gration of the public library belonging to the phyfle-fehool of Cnidos ; becaufe having thus fecured its flowers, he might the better fend them out to the world, as thofe of his own growth or culture ; which was in reality a malicious ca- calumny, for having efpoufed the caufe of truth, in oppofltion to the falfe dogmata taught by that fchool, who judged every difeafe that occurred to be of a new kind. 5. Many of his adverfaria were probably col- ledled from the inferiptions, temples, philofo- phers, and phyfleians vifited in his tours 3 but ftill the bulk mufl: be aferibed to his own great genius and extenfive pradtice ; for by his b\yn confeflion, “ He never travelled or entered'anjy^;^: “ boufe but when he had a call to fuccqur5:|hb 7 “ diftreflTed.” His magnanimity and patri6#i&ye ,^ appeared remarkably in refufing to aflift Ar^ b 2 taxerxes. XX Prog refs of Phjfology taxerxes in a plague that ravaged his army, who offered him a fee of 15,000 guineas, with other honours and advantages ; but he returned for anfwer to his Perlian majefty, that he was too rich to accept honourably any proffers that could be made from barbarians, the declared enemies to Greece. He always inculcated cha- rity to his growing difciples, by advifing them to take up with the common neceffaries of life, as a proper meafure for their ambition j in which he fet them a good example, by as readily attending the poor for nothing, as the rich for large fums. This generous difpofition led him to refufe a fee of i 500 guineas from the city of Abdera, for a vifit to their great philofopher and fenator Democritus, fufpedled of madnefs, to whom he had been formerly a pupil in pti- lojophy, Macrobius fays of him, that he could neither deceive, nor be deceived. His charity gained him from every body the love of a fa- ther j and his merits raifed him more than all the honours that are due to mortal man. The people of Argos eredled a ftatue of gold to his memory ; and thofe of Athens ordered for him crowns of the fame metal. The two greateff men of the fucceeding age, Plato and Ariftotle, propofed him as a pattern to form themfelves by j and Ariftotle chofe his ftile to be a rule for his writings 5 which has made him more concife and methodical than Plato. But at length, in a very advanced age, The/gfeat Hippocrates himfelf was crulhed in T|i^|falia, by the jaws of the common de- vourerj from whom he had refcued multitudes; and &nd of Medicine. xxi and was emtombed with due honours in the way betWixtLariffa and Gortona. Every where, for a long time after his death, Hippocrates had idol facrifices offered to him^ even much againfl his natural inclinations, which declared For no other facrifice than that of diligent ftudy in his writings, and a cai-eful tryal of their truth and reafonabienefs in pradlice. What a pagan phyfician writes to his friend Eucrates, is re- markable to this purpofe. I have, fays he, a bra- zen Hippocrates, of near a cubit in length, who when the lamp before him is out, takes a tour ail round my houfe, rattling and rum- maging over all my boxes, mixing or jumbling together my medicines, throwing open my doors, &c. and this, more efpecially if we de- lay the annual facrifice that is ufually made to him. I muft therefore declare that Hippo- crates the phyiician ftill requires facridce, and is highly difpleafed at neglefting the feflivals of divine worfhip to him, when the hated feafon returns : but he takes it kindly enough to be a guefl in the feaftings, to have his head crowned, and a libation of wine or mead poured out to him. — For the principal parts of this life of Hippocrates, we are beholden to the learned Sieur A. Dacier [in his elegant verfion of fe- veral of the moft ufeful books of Hippocrates : cntillcdOEuvres d'Hippocraies. &c. 12°. But his writings we fhall mention more, p^'ti- . cularly hereafter. §. 9. The works of Hippocrates arefinB||^f j as much fuperior in point of merit, as fHiy'Tf©: prior in point of time to thofe of his . Mhfihan b 3 . Mfdjioile y xxii Progrefs of Ph^fiology ^rijiotle j who was born near a quarter of an ag« after his deceafed anceftor, and iiluftrious pattern to him for learning, ant. Chrift. an. 384: being the fon of Nichomachus, phyfician to the great Alexander’s grand-father, Amintas; and diredtly defcended in the y^ifculapian line. But Ariftotle being left early an orphan, the appetites of his youth mifed him from his ftudies. and foon fquandered his eftate, which obliged him to take the military charadsr ; but that ill fuiting his genius, was foon relinquid:ed to renew the purfuit of his philofophical ftudics at Athens, where he io faid to have been under Plato from the age of 10 to 37 3 d-tning which time good part of iris living was gained by vending per- fumes, and medical noflrums, his patrimony being now entirely exhaufted. Here, laying afide all indulgencies for that of clofe ftudy, with eating little, and fleeping lefs, he foon got a-head of the Platonic fchool ; and gained him- felf a reputation, that after the deceafe of Plato, reached the ear of king Philip of Macedon, who made him prcEceptor to his fon, the great Alexander, then about 143 whofe education, in ail parts of polymathy, Ariftotle comipleated in about eight years. Being afterwards ful- pedred of partaking in a conspiracy againft his young mafter, all favours ceafed from that quarter, and obliged him to return to the ly- -xajum or fchools of Athens, which were now f iy^ to him by the magiftrates, that he might chair of the deceafed Plato, to which had a famous concourfe of fliudents. the difpleafures of - Alexander wore cfF> and of Medicine. xxiii off, and by degrees turned into munificent pre- fents and affiftances, that greatly conduced to the perfedion of philofophy, and the comple- tion of xA.riftotle’s ample works ; which have been iince made the ffandard of philofophy, through all ages, as thofe of Hippocrates were for phyfic, until the beginning of the laff cen- tury, when the face of both received a prodi- gious metamorphofis for the better, by a difco- very of the circulation, and a chain of im- provements in mechanical knowledge. The works of Ariftotle were left at his death to his difciple Theophraftus, with a charge never to publifh them. The executors of Theophraftus buried them under ground, and after they had fo lain near a couple of ages, they were found diverfely, bought and fold, and in great danger of perifhing, until Andronicus of Rhodes, a little before the appearance of chriftianity, got them fair copied, and difpofed in good order ; from which time, the dodrines of Ariftotle ftouriftied, and gradually fpread at Rome, un- der all the Casfars, and feveral of their fuccef- fors. The church, indeed, at firft fufpeded them of too much libertinifm, until St. Jerom, and St. Auguftin, cleared them of it. In the ftxth age, Boetius turned him into Latin ; and in the eighth century, Damafcen commented him, and reduced him to an abridgment. In the dawn of the 13th age, his works being abufed to countenance wicked opinions, caufed: th&f church to fupprefs them, until they were^g^i^f: approved and reftored to the univerfiBi^|;"iiS|^"^ Europe by pope Urban V. in 1366, and-f^cpU b 4 las xxlv Progrefs oj Phyfiology las V.in 1448. fince when they have reigned uni-? ' verfally, down to the middle of the laft century. 2. Under the reign of the great Alexander, when all branches of polymathy were taught by the fame praeceptor, and in tolerable per- fection ; his wife tutor Ariftotle feems to have firft made an offset of philofophy, from the 'Other branches of the great polymathic tree, and likewife to have made a partition betwixt philofophy and philology j as Hippocrates had a few years before made a divifion of phyfic from them both. Pliny tells (lib. 8. c. 16.), that at one time the munificent gratitude of Alexander to his wife mafter, devoted feveral thoufand perfons to his fervices in natural hiflo- ry, and to the forwarding his voluminous works of philofophy ; together with a fum, which (according to Athenaeus Deipnofophiflus, lib. 9. c. 13.) appears indeed prodigious, in refpeCt to the rate of money at that day; viz. 800 ta- lents, equal to about 500,000 crowns fferling. The laff author therefore obferves, it is no wonder that Ariftotle fliould be able to raife fifty volumes, upon the hiftory of anitnals, from fo ample a fund of wealth, with the ob- fervations and helps of fo many correfpondents, throughout all the regions of Afia and Greece. Whatever advantages Ariflotle might make of anatomical fragments from his predecelfors ' (particularly Alcmaeon, Empedocles, or even piDCmocrItus, and Hippocrates himfelf, who but' a few years before him), of which, -howler, there are no apparent hgns ; he was yerceftainly in as eminent a degree the prince ' of and of Medicine. xxr of philofophers, as Hippocrates was, in refpc( 3 : of phyficians. The advances which the phiioi fopher gave to anatomy, though chiefly com- parative, are by no means inconflderable ; and although his books concerning the hiftory and generation of animals have, in many places, ab- furdities, and even falflties, feemingly too grois to be imputable to fo learned an author : yet our great Harvey thought his time well be- ftowed, both in reading and ftudying of him, when he was employed on that fubjedl. Among other particulars, you may fee good hiflories of generation, by the egg and incubation (Hill, lib. 6. cap. 3.), In the next book, he gives a true defcription of the difpolition of the human foetus, and the gradual completion of the orga- nized parts, fo as to be evidently the founder of the anthropogenetical fyftem, which implies a fucceffive organization and appofltion of the parts, efpoufed by his no lefs admirer than cor- rector Dr. Harvey himfelf, and now more largely proved and explained by ourfelves, in the prefent compendium, §. 857. §. 10. As Hippocrates laid only the firft (tones of anatomy, fo his fyftem is proporti- onably the mbft fcanty, and the leaf! ufeful ; whence his vifceral anatomy would fall much fhort of the compafs of a good jlheet ; but as he appears to have excelled in the knowledge and practice of furgery, at leaft as a director, ,fo his accuracy and anatomical (kill appear more amf. ply and evidently extended, in his accounts oD, the bones, joints, &c. that have a nearer-a-Ui- ance to affiftances from the hand. As Hippo.^ , crates xxvi Trogrefs of Phyfohgy crates found it experimentally more inftrudlivc to himfelf, and falutiferous to his patients, to remark the naked fads, courfes, and operati- ons of nature^ medicines, and difeafes them- felves, unmixed with precarious fpeculations from any philofophy ; fo he appears no friend to any one theory, more than the evident and fenfi-ble qualities of heat and cold, denfe and rare, foiid or fluid, &c. apparently connected to the objeds under his enquiry. If this aver- lion to theory will not entitle him to any ho- nour in founding the dogmatical or reafoning fed, we apprehend his fyftem has fufrered no material lofs by it, unlefs the philofophy of thofe times had been more perfed : or even if his great fucceiTor Galen had altogether purfued the fame method, his works would have been doubtlefs as much more improved in their pradi- cal ufefulnefs, as in their brevity. 2. His PRACTICE was generally to leave the whole courfe of the difeemper to nature, under a due regimen, until fome very urgent fy.mptom or change called for his afliftance ; and then he as- boldly attacked it by remedies, equally po- tent j fuch as exceflive blood-letting, ad deli- quium, exceflive dofes of draflic medicines, that both vomit and purge, hot and cold bath- ing, cupping, undions, clyfters, &c. In acute difeafes, he relied principally on plenty of emulflons, hydromels, grewels, and a v.^atery - 4kt,y^iving cordials when the heat feemed too 2 ^^^v|ind' bleeding, bathing the feet, &c. when ^^^amtoo higli ; patiently waiting for the con- c^^on of the morbific matter, - by the powers 6 of md of Medicine. xxvii of nature, and as diligently watching the out^ lets, to which it had a tendency, where he then always promoted the difcharge, if it feem- ed to require affiftance, from evacuants. He dire6l:s caftor and myrrh for hyfleric fits, fup- prefled menfes, and moft diforders: of women. He gives vinegar in quinlies, and ardent fevers, with hiccups, vomitings, phrenzy, peripneu- mony, and pleurify : alfo for vifcidities in chronics, dropfies, external pains, inflammati- ons, and cutaneous dei.edations, &c, Garlick for cold phlegm, and eryfipelas of the lungs. jdlum to cure haemorrhages, uterine difcharges, and procure conception. Spices for phlegmatic diftempcrs of women, and to promote the menfes. Recent ox-galh to loofen the bowels, kill worms, purge children, relieve dropfies, &c. ’* Cantharides in dropfies, and to provoke the menfes. Diet of onions in a jaundice, and to provoke conception. Long abftinencies from food, for the cure of dropfies, jaundice, diarr- haeas, gouty or rheumatic pains, affhmas, and diforders of the lungs, or fpleen. Clyjiers for pains, inflammations, and over-fu!nefs in the head ; dry, hot, and windy cholics, pains of the abdomen, womb, pleurify, fevers, pains of the loins, &c. Concu[jions towards replacing the bones; and to the dlfcovering of confined pus or matter. Cupping for pains in the head and eyes, bruifes, peripneumony, pains of the hip and other parts. Elaterium to purge expel the foetus, or purge in cancers, ulcefs^j jaundice, fore-throat, &c. FriSiions^ with pi|, • ' to flrengthen weak joints, and relax ftilf dfresf r. ■ Cold- ■ xxviii Trogrefs of Phyjiology Co>d-bath, for faintings and hyfteric fits, rc- ftrain the menfes, prevent mii'carriage, rheu- matic pains, &c. bu" to be cautioufly avoided in diforders of the lungs and liver, tabes, &c. Galbaniim^ as a uterine medicine, and an ex- pectorant in a peripneumony. ymiiper-berrieSy to provoke urine. He calls eggs lac pulli ; and advifeth ajfes-milk in exceffive fluxes from the bowels, or womb ; for flow-fevers, confumpti- ons-purulent, diforders of the lungs, gout, &c. Lintfetd in wounds and ulcerations j and out- wardly in emollient anodyne fotus’s. Sower oranges^ or fmelling-apples, in drinks for fevers. Mecoiiinum for exceffive fluxes and pains of the uterus. Honey as a refolvent in fevers and phlegmons j as a peCtoral in coughs, and a laxative in clyflers. Mint as a cordial and a fliomachic 3 for jaundice, and vomitings, &c. Myrrh, for moft diforders of the flomach, and menfes ; and to cleanfe ulcerations in the mouth, gums, and other parts. Nitre from i^lgypt (redifh, and more lixivial than ours), forquin- fies, pleurifles, gouty and rheumatic pains j alfo to purge phlegm from the bowels, water in an anafarca j for fcirrhoflties in the womb, or elfewhere. Origanum for cold-phlegm, drop- lies, jaundice, &c. -Egg-t, their whites to be given in fevers, not ardent, in the drinks 3 and their yolks for coughs in children, exceffiive uterine fluxes, &c. Po^y-juice for hylleric and convulfive diforders, heClic fevers, 'p'^ia^es of the bowels, &c. The water from ^pitch or tar, and the pitch cr tar itfclf, inwardly ulcers, to expel water from the womb, 6ce. r‘. : Pepper V dnd of Medicine. xxix "Peppery topically for the tooth-ach, and for cramps. Cerus of leadj for diforders of the eyes, Ikin, and {harp ulcerations. Penny-royaly for fevers, and hyfterical diforders. Refn of turpentine, for inward ulcerations, and exceffive fluxes, uterine, &c. RoJe-IeaveSy for a diarrhasa, diabetes, and uterine relaxations. Elder-berrieSy to purge, in dropfies and uterine diforders. Scammonyy root and juice, to purge in hip-gout, jaundice, nephritic complaints, &c. Squilly to , purge in uterine and pthifical cafes. — Tappingy for a dropiy, and empyema. Whey-drinking, for the cure of ulcerations, confumptions, fe- vers and gouts. Ajfa-fatida, for hyfterics, pe- ripneumony, pleurify, jaundice, &c. and in a larger dofe to purge bile. Sulphur, for ulcers, pulmonary and cutaneous diforders. Frankin- cenfe, for ulcerations, puerile afthma’s,ftomachic and uterine diforders. Vence-j'eBion,^ with a large orifice to relieve diflending pains of the head, eyes, throat, lides, oppreihons at the heart, and mouth of the ftomach, fuppreffed urine, &c. but to be omitted when the pains are to be fuppurated, &c. 3. This may fuffice to give us fome notions of the chief articles in the materia medica of Hippocrates, with the ufes to which he applied them j and this, we fee generally in a confor- mity with our pradfice at the prefent day. His phyfiological and nofological fleill were {fill much more fuperior. He had a happy readi- nefs and fliarpnefs of penetration into the.jftate of a patient and his diforder, from all collateral fymptoms 3 by which, and from long obfer^a- XXX Progr^fs of Phyfiology tion, he was almoft infallible in his prefages of their crifes, turns, and future events. In points of furgery, himfelf and his Latin imitator or tranfcriber, Celfus, have both of them per- formed to a wonder. His morbid cafes or hiflories are fully and mod: accurately ftated j and with fuch an impartiality to truth and in- tereft, that few, if any, can be hnce compared to him ; for he does not fcruple to own the leafc circumftances of his unfuccefsful pradlices. His aphorifms, engliihed by Dr. Sprengal, with his tradls upon regimen of the non-naturals (elegantly turned into French by Sieur. A. Da- cier, and in part englifhed by Dr. Clifton), afford not only the beft part of his pradlice, but are filled with a fenfible philofophy, con- cording with the circula ion, and able to endure the teft of the prefent and future ages j as you may fee plainly in the nervous, ufeful, and fevere tryals to which Dr. Gorter has lately fubjedled each of his aphorifms, in point of found prac- tice. V. Comment, in Aphor. Hippoc. Lug, Bat. 4to. 1740. & feq. 4. He juflly, with ourfelves, divides the bo- dy into retaining folids (ra and in- cluded fluids (ra luKrxofievci ) ; under which laid, he ranks the movers of the body and mind, now called nervous fpirits. He diflin- guifhes the red blood from the yellow and wa- tery ferum ; and obferves, that in the firfl: there is contained a fibrous fubftance, which being ydrawn out from it, the reft will not congeal. ainly to have known the perfpi- tion and inhalation, that obtains through Heiappears pi tat ion, ex ha la and of Medicine, xxxi through all parts of the body ; on which Dr. Kaw (a relation of our great Boerhaave’s) has given us a profefTed, elegant, and ufeful treatife, entitled Perfpiratio Hippocratica. And it is no lefs plain, that he knew the blood and juices had a circum rotation or return through thefe- veral parts of the body ; although he knew not how or which way it was carried on, by the nature and organizations of them. See the re- markable paffage in lib. de infomniis, n°. 13. But fince either abridgments, or whole co- pies of fo confiderable an author,® are in the hands of almofi; every one of the profeffion ; in- ftead of further details, we refer them to the original j of which the late Venice edition, 1737, tranflated by Cornaro, is the moft ufeful, to a novice or a bufy praditioner, on account of two indexes, each as big as the original work 5 which is here turned (1.) into a fyftem in al- phabetic order, by Marinelli ; (2.) a concord- ance, or index, by P. M. Pinus. 5. Only we fliall by the way remark one thing furpriling to fome, why in the midft of fo accurate attention to all the other figns, both diagnoftic and prognoftic, that are at this day regarded by the greateft phylicians all over Europe, Hippocrates fhould have taken fo little notice of the pulfe, as barely to mention it in a very few places. To this we. anfwer, that his clofe repeated and ingenious obfervation of refpiration *, {now commonly as much^-ne- gleded, as the pulfe was by him ) in regard to" . its magnitude, frequency, ftrength, facility^. - &c. with their degrees and oppolites, (howed'-'.f botftr xxxii Progre/s of Phyfiology both to his eye and ear, all and more of the? fame inftruftions than he could learn from the pulfe j which being only a confequence of the former, and of the fame import^ eahly fluflu- ating or deceptive in various parts, and under various influences, he often neglefted it as lefs to be trufted, and not fo apt to furprife or found his fame in predid;ions : although he has left ViS enough to flaow, that he confulted the pulfe of the arteries, as a fign in all fuch cafes as he judged to require it. R E M A R K. Here I mufl: confef?, that although I cannot aquiefee with the learned Dr. Nicholls, in his late elegant preleflion,^ de anma medica, Lond. 4to. 1750. in allowing the mind any other operation upon the body than what is re-a6lional, direftive and conformable to the imprelTions which the body itfelf, firfl: organized, conveys to her, fo as to de- termine her re-adlion, which in confeious changes we call the will yet I muft own, that an after- ' thought, upon what in my younger days feemed an abfurdity, has made me admire the wifdom of the ancients, in giving the fame name to the diaphragm ((p^£VEj), which is ufed to denote the mind, of whofe various ftates or conditions it is no lefs an index than to thofe of the body. For this part is adtuated by the common fpring of nature, the atmofphcre, at the birth, before there are any powers of will, to which it afterwards pays certain degrees of obedience. This part appears to be the regulator of the heart, and by that alfo of the encephalon, and by both of vthg bodily atfedtions or impreffions upon the con- ^ feipus mind ; and this even on the firfl day of birthj .Ibhg before flie has any confeious determinati- ons of will and on the lad day of life, long after both will and confeioufnefs have ceafed ; fo on the ether a? 2 ci of Medicine. xxxiii other hand, the re-a6ting mind returns her opera- tions primarily and principally by the nerves of thefe parts, to the reft of the body, in producing all the morbid affections, afcribed either to ele- vating, or depreffing and forrowful, paflions of all kinds. Hence the natural languages, or vocal cla- mours of all animals immediately refult, expreffive of their then confcious ftate, to any ear they can reach : for as the mere tones of voice, conformed to the intentions of the will in man, are able to exprefs different fenfes by one and the fame word, fo there is hardly an obferving perfon, but what can readily determine, if they hear the voice either of man or beaft, articulated or not ; whether it arifes from a paffion that is forrowful, joyous, or indifferent : for whenever the mind, has fo far deferred the fo- ciety of the body from any infirmity thereof, as to be incapable of paffion or will, ffie can return no effedts of them upon the body, and confequently can return none of their effedts again by the voice or other adlions of the body. Hence there is an elegant paper in one of the philofophical tranfadli- ons, intimating the way of judging people^s general and prefent difpofitions, both of body and mind, by the natural and common keys or tones of the voice. But to trace this matter through man, and other animals in general, is a fubjedt indeed curious, ufeful, and elegant, but too long for this place. . §. XI. After Hippocrates had made phyfic a liberal and diftindf art, to be further perfefied by obfervation and pradtice, his works cpliti- nued, making fome improvement in the hands of his fucceffors, the Afclepiads, or defcendants- of iEfculapius, until about the dawn of chriftia-.^ nity, both the original and the additions accurately digefted and improved into a km^^' VoL. I. c new xxxlv Trogrefs of Pkyfiology new fyflem, by a learned Greek, named Arf- Tj^us Cappadox^ in four books, entitled, Con- cerning the caufcs and Jigns of acute and ckrcriic difeafes-, of which the Oxford edition, by Dr. Wigan and Mr. Mattaire (fob 1723), is as near good as any fince made. This phyfician, who feems by his writings to have pradifed at or near Rome, has given us more exad and beau- tiful hiftories of difeafes, than are to be found in the reft of the ancients ; and his methods of cure are proportionably m.ore elegant; but un- fortunately the whole is in many places imper- fed, by the lofs of whole chapters. He feems to appear with all the fuperiority over Hippo- crates that time and colledions could aifbrd him ; and is not equalled, either in method or elegance, by any writer after him. He is the firft that applied cantharides for the ufe of blifters ; he ufed bleeding ad deliquium in a quinfy, and applies much to the mafculine pradice of the Romans, by diet, exercifes, bathings, fweatings, fomentings, &c. But his elegant deferiptions are moft valuable, becaufe juft, compad, in one continued narrative, and placed in a good order. The like we may fay of the Latin Hippocrates, Celsus, who wrote foon after him, in a choice Roman didion, ‘ equal to the maieftic and elegant Ionic dialed of AretEEUs’s Greek. Therefore if we add thefe to the learned expofitor of Hippocrates, Ga- EEN, who flourilhed foon after Celfus, and in ; the fame great city, we ftiall hardly meet with writers worth notice afterwards, unlefs it be ■-X'Trallian, down to the end of the ijthcen- and of Medicinet xxxv tury ; or even in the following 1 6th age, little more was done than varioufly cutting and carving, contrading or dilating the dodrines of thofe fathers, after divers forms and manners. Of Celfus, you may confult the Padua edition, 8vo. 1746. in which are contained Morgagni’s elegant .obfervations and remarks in five or fix epiftles. REMARK. * Thofe who are curious to trace the fteps by which medicine has defcended from the hands of Galen, into our own, at the prefent day, may com- pare him, or his abridgment, by Lacuna, with (i.) ^diCohus Sylvius, Parifian profeffor^ then {i.) Rio- lani opera, fob Par. 1610. &feq. (3.) Sennerti ope- ra. (4.) River a opera. (5.) Etmulleri opera, (6.) Hoffmanni opera. (7.) and laftly, the theoreti- cal and pradical courfes of our late illuftrious Eu- ropean .ffifculapiusj Bcerhaave *, the former given us by Dr. Haller., re-printed with the text, in feven volumes 4to. Ven. 1744, and the latter half pub- lifhed, and now on the anvil, by Dr. Sv/ieten, at the imperial court ; to which add the works>^of his diligent and well commended fcholar. Dr. Gorter. §. Xll. The great luminary of medicine, Galen, whofe works have eclipfed all thofe of' • his cotemporaries and fuccelfors, down to the . ' . times of Plarvey, founfhed at Rome, dupipg--* the latter part of the fecond age of chriftidnJiy, ■* / was by birth an i\iiatic, or Greek, born at the city of Pergamus, fon to the expert . rn^tthefaa- . tician and archited:, Nicone, an. Chrifti. After compleafmg his ftudies at Alexandr|lfl^^J 4 gjT^ , began his pradice, at the age of .3,4 c 2 ■ ^^"7./ L: \ '■ xxxvl Progrejs oj Puyfioiogy after travelled to Pvome, where he wTote his fo much admired and voluminous .works, filled with learning of all kinds. He afterwards re- turned into his own country, but w'as foon re- called to be chief phyfician to the emperors Antoninus Pius, and Verus ; after whofe de- ceafe, he retired again into Afia, and there died in an advanced age. Galen has fupplied to us the common fountains from whence the phy- fiology of the human body has been taught, for near fifteen ages after him, down even to the times of Harvey j and although he is gene- rally tedious in his exprefiions, often unfettled in his opinions, and frequently gives us confufed intermixtures, by tranferibing both the human and comparative anatomy, intermixed together; yet he is ftill a very deferving and profefied ana- tomift, the laft of the Greeks, the mofl emi- nent of all the ancients, and far from deferving many of thofe aggravating refledlions thrown upon him by Vefalius; more efpecially that of having never traced the human body itfelf, by his own labours ; the contrary of which is evi- dent, throughout his book de ufu partium ; and from the pafiTage (lib. 3. cap. 2. de comp. . med.), wdiere he tells us, the bodies of barbari- 'ans, killed in the battle of Mark Antony (an. 174.), were given for difiedtion to the Roman phyficians. We are probably obliged to Galen for the works of Hippocrates himfelf, no lefs ■ than for many remarkable palTages of the anci- ents', that are not elfewhere to be found. In his Glfaif'ltreatife on the ufe of the parts of man’s ■’ 4 f^' 6 av, he evidently deferibes the foramen ovale, , - and and of Medicine. xxxvii canalls arteriofus in the fcetus, the true courfe of the blood through the lungs, with the ufe of the valves, &c : he has left us alfo a number of autographicaldefcriptions, and experiments on living animals, no lefs ufeful in phyfiology than pradlice ; in which laft he appears throughout truly the great man in all his works, which with thofe of Hippocrates and Celfus, will ever continue to be a pleafurable and inftrudtive en- tertainment to all who have judgment, time,, and ability to read them. Galen’s books con- cerning the powers of fimple medicines, have been tranfcribed, with but little alteration, into Oribafus, Mtius^ and Paulus JEginita j and they alfo form the chief part of what the Ara- bians have afterwards given us upon the fubjedt of Ample medicines. His diftindlions of the various kinds, caufes, and fymptoms of all dif- eafes j particularly fevers, IhoW the penetrating depths of his genius, above any of his prede- ceffors ; and his perfect acquaintance with the philofophy of Ariftotle, that then flourifhed at Rome. His Ax books concerning the know- ledge of the feats or parts affeded, in difeafes, are both valuable and admirable, beyond other parts of his works, of which they were proba- bly fome of his laA ; and are preferable not on- ly for their good method, and more compad didion, but for the juAnefs and validity of tHe diagnoAic Agns, propofed for difcovering the more obfcure difeafes, and for the many obfer-. vations he has given us from pradical anat(^y. . Nor are his merits lefs in prognoAics, . thj^^„^-" miotics 5 only we muA difregard the ufelefldx-^' c 3 xxxvlii Progre/s of Phyfiology ceffes, to which he has, in complalfance to Ariftotle, extended the peccant qualities of hu- mours ; and the endlefs variety of pulfes, that are not perceptible to the niceft a-nd mod expe- rienced touch. His three books upon the na- tures or powers of aliments, have continued the ground-work of all that has been faid on diet by his fucceffors 5 and his difquifitions into all the kinds of foods, with their relations to an eafy or difficult digeftion in the Ifomach, (how the greatnefs of his judgment, and the extent of his experience; which are both of them dill more confpicuous in his fix books upon the pre- fervation of prefent health ; in which, beddes the aliments, he confiders their relations to the feveral ages of man, from the birth and up- wards, advifing, in conformity to the age, fuitable exercifes, fridlions, bathings, evacua- tions, wines, and foods, contrary to the morbid difpofitions. Of thefe books, formerly Sandfo- rious, and latterly Sir John Floyer, have made a very good ufe both in their pradice and writings. Sir John tells us, that Sandforius made his great difeoveries upon the important fubjedb of perfpiration, from rcfledting on the following pafl'age of Galen’s fixth book de fani- tate tuenda. Mgrotare ciitan [blent icl hu- morum n)itio, vel redundantia. Uhl igitur qiicd exhaJat d corpore minui eft in quee ac- cepit \ redundantlee orirt morbi ftlent. ^are projpiciendurn ef, ut eorum uus edir.tur. cff b:- . ' ^y^ftfuntur refpechi eorwn ques expelhintiLr^ fer'vetur hy ' "^ fonve?iiensmediocritas. Servabitur fane u mo- X : 'duifi ponderetur in nobis utnfque quantitas. Et and of Medicine. xxxlx pori'o de nutrimenti, 'vel quantitate^ 'oel quali^ tate, vel etiam utraqiie detrahimm. This by the way may ferve as one Inflance, how ufeful a cool reading of the ancients may be in the hands of able profeffors, even merely to excite a fpirit of invention, and aftord difcoveries, which perhaps the ancients themfelves were very little acquainted with. As for furgery, it muft be owned Galen falls very Ihort of his predecefibrs, Celfus and Hippocraies: and indeed he feems to have been not very fond of it, when he tells us, that “ as an emperor mull: fometimes go “ and fight himfelf for a foldier j fo a phylician, “ in cafes of neceffity, mufl make ufe of his “ hands.” However, he has largely enough treated upon inflammations, tumors, wounds, ulcers, blood-letting, cupping, fcarification, &c. §. XIII. ’Tis univerfally allowed by all good profeffors, that Hippocrates, Ariftotle, and Ga- len, form together a triumvatic fydem of the ancient anatomy j which, if digefted would even at this day make a very formidable ap- pearance, and go near to equal the mod: conh- derable additions that have been fince made by others, even down to the arifing of the three greateft luminaries of modern difTedion j viz. Vefalius of Paris, Euftachio of Rome, and Harvey of London. But thofe who through choice or incapacity dedre to be difencumbered with the volumes of the triumvirate, may reft fatis- fied with a marginal abridgment of them, that attends the anatomical fyftem ofCafparBauhmf, * Cafpari Bauhini Theatrum anatomicum Fraifichforti 1621. & 1640. 4to. . c 4 whieh. 3d Progrefs of Phyfjology y/hichj joined with the faid luminaries, and the trails of accurate Riolan will very well bring down the date of anatomy to the midd of the lad century j and then the lad edi- tion of Bartholin joined wdth that of Ver- heyn will reduce it to the dawn of our pre- fen t age. 2. Thofe who defire to be acquainted with fome of the principal matters contained in mod of the Greek and Latin writers, who followed after Galen, down to the reditution of learning by the art of printing, in the middof the 15th age, may confultDr. Frcind’s hidory of phyfic, for that period. For in reality, the additions made to the art of healing in that interval, are fo incondderable, that if we except half a dozen writers, the red may he over-looked without any fenfible lofs. Of thefe the nrd confiderable author, contemporary with, or near to the time of Galen, is Ccelius Aurelianus, Siccends ex Africa, in his eight books, de morbis acu- tis & chronicis, qto. Amdelod. 1722. who is not only jud in his figns and defcriptions of * Riolani Archiatri Enchiridiion Anatomicum cum diflertationibus adjeclis. 8vo. Paris. 1658. Animadverfio- iies Anatomic-.e, 410. Load. 1649. f Thom. Bartholini Anatomia quinta vice ad circula- tionem reformata Lug. Bat. 1686. ■ X Philippi Verheyen Anatome, Lovanienf. 410. 1693. without which fyftem, you will meet with the gold picked from the drofs, in Dr. James KeilPs anatomy of the hu- - man body abridged, 1 2mo. Lond. 1698. or rather Dr. Drake’s Anthropographia ; in which you have alfo many ■ -\of‘the figures and obfervations of the ingenious Mr. '.Xowper. . difeafes. and of Medicine. xli difeafes, but has preierved to us many fignifi- cant fragments, from the ancients of his day, that are otherwife loft to us. Among other particulars, he takes notice of the haemorrhoides or piles, in the coats of the bladder, that bleed periodically, or at uncertain intervals ; and is a cafe that occurs fometimes in our days, no lefs than his. Oribaf.us^ of Pergamos, who flouriftied phyfician to the emperor Julian, in the midft of the fourth age; was a pagan, like his mafter, by whofe order he gathered feventy books, under the name of collcds, from the moft eminent ancients; of which only the firft 1 5, with the 24th and 25th, are preferved to us. Phy lie appears thence to be already degenerating, at leaft v/ith Oribaftus, towards recipe and fu- perftition. However, he has many pertinent fragments of the loft ancients ; and the difeafes, of which he is the firft deferiber, may be feen in Dr. Freind. Mtius Amidenus, who next flouriftied in the clofe of the fifth age, one of the firft among the chriftian phyficians, is more ample than Galen, in refpedl to furgery. He highly commends and describes feveral kinds of cauteries ; and ufes fcarifications of the ancles in. dropfies. He treats of blood-letting, finapifms, clyfters, peflaries, the bites of animals, hernise, abfeefles, feirrhi, cancers, and enceyfted tumors. He has freely compiled from his predeceflbrs, and tranferibed almoft the whole of Oribafius, upon fimple medicines, into his fecond book. But in points of furgery, he appears much ful|gf^. than Oribafius ; although he fubjoins an infinite, number of recipes to each diftemper, with IbJ^ detaifj xlli Progrefs of Phyfology details of their virtues j which are plain Indica- tions of the idle, ignorant, and fuperftitious condition into which the art of healing was then about to dwindle ; together with the language and the other learning of the empire, Alexander Pralltan of Lydia, in the lelTer Aha, fiourlfhed in the midft of the fixth age, under Juftinian ; faid to have been a good chriftian and phyfician to St. Leo the great : though one of the laft in order, is the hrft upon the line of merit, next to Galen. For he has given us a concife, juil, and fyftematical delcription of all difeal'es and their medicines, from heaa to foot j but without including lurgery, or the difeafes of women. In his pradlice or curative part, he has greatly excelled both Hippocrates and Ga- len ; he lubdues quinfies by repeated blood- letting, an haemoptoe, by bleeding in the foot, coolers for erylipelatous fevers, worm-wood for batlard-tertians, &c. He is one of the firft that commends bleeding in the jugular 3 and remarks the aftringent virtues of rhubarb, &c. A compendium of him may be feen in Englilh, by Dr. Milward; Lond. 8vo. 1734. Trahian -quotes his predeceflbr ^Ltius, as he himfelf is * jquoted by his fucceffor, Paulus yEgineta, in the ■.-clofe of the feventh century. JEgineta is the laid -upon the Greek iid, and has fupplied the parts of furgery, and midwifry or difeafes of v\omen, which Trallian had omitted, and from whom in moft places he has largely tranfcribed. His ,;,,defcriptions of difeafes are compadl, and taken V.^hi^fly -from Galen and Oribafius. You have \:his works in Latin at Paris, 1532. fol. and from . ■ the and of Medicine, xliJi the prefs of Aldus at Venice, with notes, 8vo. 1553, and 1554. 3. After the Roman language and arts had been ruined in Italy, by the Lumbards, and thofe of the Greeks much declined in the eaft, about the clofe of the fixth age ; foon after there arofe a crafty impoftor, Mahomet, who in the beginning of the feventh age, endeavour- ed to fupprefs learning and arts in others, the better to eftablifh his own empire and fuperftiti- ons; although at the fame time he is faid to have known fo much of medicine himfelf, as to write a book of aphorifms. He and his fac- jceflbrs removed phyfic, with the fchools from Alexandria, among thefalfe priefts and prophets of their own tribe, to cities called Harran and Bagdat ; and after carrying their empire with the rapidity of a torrent, over moft parts of Perfia, y^rabia, iEgypt, Alia, Paleftine, and Africa, they tranllated what was thought va-, luable of the fciences, into their native Saracen, or mixed Arabic language, and foon fulfered both the lirfl; fountains, and the learned lan- guages, to perilh in favour of their own. In the beginning of the eighth century, they be- came makers likewife over a great part of Spain, where their MulTelmen alfo obliged the remains of the fciences to fpeak their own dia- Ie6t. Phyiic rather loling than gaining in the hands of the Arabs, however maintained- its bulk, and gained fome things, while it loft others; particularly their own pra 4 lice, often lead them to milder and better medicines, th^ w_hat had been ufed by the Greeks,; only by-^^: much: xliv Progrefs rf Phyfiohgy much neglediing the Hippocratic knowledge of dihempers themfelves, they ran almoft en- tire into the Galenic forms and compolitions. Among thefe flourilhed Serapion^ in the clofe of the eighth century j John of Damafcen in the midfl; of the ninth ; Rhazes, praefedl to the hofpital of Babylon, in the dawn of the tenth age. His works (how him to have been one of the greateft Arabian phylicians, as they make a conliderable folio ; Bafil. 1544. and include all branches of phylic and furgery, with many things new, and ufeful in each : here we have mercury fublimate, and many other chemicals, a proper defeription and cure of the fmall-pox and meafles, &c. At the clofe of the tenth age, Haly-Abbas gave a full compendium of phyfic. In the dawn of the i ith age, Avicenna^ of Buchara, or Ulbec in Tartary, who has compiled a large fyftem from the Greeks, Avenzoar was a Spanidi Arab, native of Sevile, and prssfedt of the hofpital there, in the 1 2th age : contrary to the cuftom of the time and place, he pradlifed both furgery and phyfic, together with great judgment and fuccefs, and has left many good obfervations, rare cafes, ufe- , f«l and new medicines, &c. fol. 1496. & feq. 'Venetiis. Averrea was alfo a native of Cor- duba in Spain, a fubtle Ariftotellian ; but after- wards taught, and died in the city of Morocco, an. 1 166. leaving nothing remarkably ufeful in his works. After him followed Mefue^ who :e^■ceIled in* the Galenic pharmacy. The Arabian phyfic, was, in the clofe of iith age, put into a Latin drefs, by Con- Jlanus and of Medicine* xlv ft anus the African, of Carthage, who is faid to have lived 39 years in the city of Babylon. He in the year 1087, carried it to Salernum^ by Naples, the firft and oldeft fchool of Italy; where he left his feven books de Morborum cognitione & curatione ; the manufcript of which is faid to be ftill kept at Vienna. He afterwards died at Monte-Caffina ; and his works were printed, Bafil. 1536, & 1539. fol. This Schola Salernitana, is the oldeft for phyfic in Europe, and grew up from an unknown origin, ’till it got a conf^derable name in the midft of the i ith age, by fending rules of diet in verfe, for our prince Robert, an. 1 06a, fon to William the conqueror : and in the clofe of the 1 2th age, it got the name of the Hippocratic college, configned from abbot Joachim. §. 14. As the reviving arts in general began to lift up their heads in that quarter of Europe, which we call Italy; fo phyfic and anatomy made their more early and confiderable ap- pearances in that country, efpecially the fchool of Salernum, by Naples, before they travelled on to France, Germany, and Britain. The firft dawnings of anatomy were probably in Si- cily, under the emperor Fred. II. who at the clofe of the 13th age, erected Sardinia into, a kingdom, for his fon Ellzo, who died under confinement at Bologna ; for he enadled a lavv, that none fhould be allowed to pradife in fur- gery, who were not difiedors in Anatomy : but his firfl phyfician, Martian, got leave to reduce it to a public adminiftration, every -five year,^- at which all phyficians and furgcons were.'fd' xlvi Progrefs of Phy/tology their attendance. Soon after this, Mundinus became fo celebrated a profeflbr at the univer- fity of Bononia, in the entrance of the 14th century (where anatomy had been taught for an age and a half before him), that a public law was obtained for obliging all dodlors in Italy to lediure out of no other book than that publifhed under the name of Mundinus, at Bononia, in the year 1315 s in which, howe- ver, as well as his commentator J. B. Carpus, there is fo much rufticity, both in the didioa and the defcribed matter, that the book has little to recommend it, more than its antiquity. 2. But in the midft of the faid 14th age, flourifhed Guido deChauliac, who being in ho- ly orders, was no lefs chamberlain and chap- lain, than principal phylician to feveral pontiffs of the holy fee; but is much more confiderable for his writings in furgery, than for the col- leded abridgment he has left us upon anato- my. He was an eye-witnefs to the general plague that invaded, not only Italy, but all Europe, in the year 1348; and of which fo many died, here at London, that in the faid year 50,000 were buried in the church-yard of the charter-houfe only : which plague he af- terwards defcribes in his works, wrote in 1363, at Avignon (which had from the year of the faid plague, been made a retirement for the pontificat), under his mafter Urban the V. who is himfelf faid to have been the fon of an En- glifh phyfcian. In the days of Guido, fur- g'ery had been fo far loft, that the beft pro- feflbrs in Europe, four of whom were in the 4 facer- and of Medicine. xlvii facerdotal order, fcarce knew how to treat a fimple wound. Rogerius of Venice, and Ro- land of Parma, knew no better than to poultice them with a few herbs, mixed with wine and honey ; Bruno of Padua, and Theodoric, bi- fhop of Cervia, relied upon fweet wines, mixed with reftringents j Salicetus, profeffor of Vero- na, and Lanfranc of Milan (who wrote his works at Paris, in the end of the 13th age), preferred the ufe of fweet-ointments and plaf- ters ; nor is any thing better propofed by John of Gaddefden, under king Edward II. and III. in his Rofa Anglica ; but the Germans treated their wounds by charms, and mixtures of oil and cabbage. 3. Guido being a man of letters, one of much reading, and affifted by the pontifical li- braries, took upon him to relieve this dearth of chirurgical knowledge (that had prevailed, from the time when medicine paffed, from Paulus fEgineta, into the hands of the Arabi- ans, at the clofe of the fixth age, among whom it lay buried from Europe fix ages more), by recolleding the operative parts, as far as they had been treated in Galen, ^Egineta and the Arabians ; not neglecting what he thought ufe- ful in his cotemporaries, Theodorus, Salicetus and Lanfranc. The former, Theodorus, though averfe to all operation, had recommended tur- pentine as the beft application, for wounds, of the nerves ; with a double ligature, upon the artery, to be divided, for fuppreffing an has- morrhage. Salicetus had approved futures fin- wounds of the abdomen. Lanfranc had treated : on xiviii Progrefs af Phyfwhgy on the operations for the ftone, hernias, and dropfies; although tapping the abdomen for the laft, he fays, was always fatal in the end. He firfl condemned the ufe of tents, and advifed futures of tranfverfly wounded tendons, in which Thcodoric had been timorous. 4. Guido, however laudable in his writings, and experienced in his pradlice, is not to be commended for ufing futures in lithotomy, and caftration for the cure of hernize. He both ufed and defcribes the trepan for wounds of the brain, while others trufted only totopicals; he ufed futures of the tendons, with good fuccefs, and defcribes a great number of inftruments for various purpofes ; and among them are forceps for the tying up of arteries, &c. From all which he has defervedly gained the repute of being an Hippocrates, or reftorer of forgery to Europe alfu the firh that feparated or planted off furgery from phyfic, reduced it to a diflindt fyflem, and confirmed it by his own repeated obfervations and experiences whereas the off- fet of pharmacy, is much later. 5. Some time after Guido, men of letters began to perceive the merits of Hippocrates, Celfus, and Galen, above the Arabians ; who had been as yet the ftore-keepers and retailers of learning, from the feizure they made of it, together with Spain, in the dawn of the eighth century, even down to the 12th and 13th age, when by retailing the Greek learning in their own drefs at Toledo and-Corduba, they ac- quired great fame, by a condux of dudents from the-' other, at that time ignorant countries of , ’ 1 ' Europe; and of Medicine, xllx Europe ; where the returning ftudents appeared fo rfluch more learned than their neighbours, as gave occalion for a rumour, that Demons protelled and taught the arts, about thofe cities of Spain, where even block-heads might be- come learned for their ftipend. 6. From thefe aucient Moorifli univerfifies of Spain, aftrology, phyfic, and chemilfry were learned’ and carried into France, by Ar- noldus de Villanova ; and by Peter d’Albano, to Padua, at the clofe of the 13 th age. But they no lefs than our Oxford R. Bacon, fuf- fered for thbif extraordinary knowledge, by the popular, blit unjufl imputations of dealing in magit'or foreery.— -During the fourteenth cen- tury, arts and fciehces made veryinconfiderabie advances in Europe, until the refugee Greeks, expelled from their , metropolis, by the Turk, and the difcovery of the art of pfi’ptfhg in the midfl; of the 1 5th age, revived the drooping fpirits of Minerva!, and amply difTaftrl true' and ufeful knowledge through all , tHe veins of Chfiftendom. The Greeks havipg ,op'ened the learned treafures of their country in ‘Italy, they were fo’on fent abroad at an eafy f ate by print- ing,- both in their ptiniitivt, and in the Roman drefs. Celfus came out at Florence in 147S, and -dt Milarr in 1481. Antrotle and Theo- phraftus at Venice, under Aldus, in 1499; and foon after, from the fame prefs, came Di- . ofcorides, Galen, Hippocrates, PaUlus, -&c. In the dawn of the i6th age, fome of the' . (harper wits, who had digefled upon the fa^f^p F thers of learning, began to perceive, . that all% Vpl. I. d 1 Progrefi of Phyfiology though Ariftotle and Galen had been pe- remptorily ereded as the touch-ftone for all truths ; in behalf of which, a philofopher could have no where any quarter further than he had their arguments to fupport himj yet they found the fprings of nature, no lefs than thofe of hu- man underftanding, continued to be ftill the fame ; and that even thefe oracles were no further meritorious than as they had faithfully trodden in the fteps of nature herfelf, at whofe tribunal Vefalius was one of the firfl who with a laudable courage, called over the juftnefs of their titles ; upon the fumming up of which, as Ariftotle and Galen were found preferable to the Arabians, fo Hippocrates and his imitator Celfus, appeared fuller of truth than them all, Thefe meafures foon bred a party, chiefly in France, who difcarding the absurdities and idle theories of Galen and Ariftotle, efpoufed no- thing but what they canvafed by the rule of fen- iible experience, and plain reafon, under the name of the Hippocratic fed ; becaufe Hippo- crates, regardlefs of all nominal authorities, has perfued the fame courfe. In this lift, after Velalius, vve rank Jacobus Sylvius, our Britilh Cajus, and Sir Thomas Linacer, Baillonius, Duretu?, and their refpedive difciples Jacotius, Heurnius, Mercurialis, Fcefius, &c. whofe writings are therefore at this day both legible -and inftrudive. §. XV. Vefalius was born in the beginning C>f the 1 6 th age, with a fpirit for the reftitution of anatomy, to which he applied lb arduoufly, di-Vithat he gave public ledures in Lovain and Pa- ■': # • - 3 Cftd of Medicine. li 'ris, by the age of i8; and became fuccef- iively its profeflbr to the univerfities of Padua and Bononia. He was at laft fixed in that of PI- la, by a falary of 200 pounds fterling per an- num, at his 23d year of age j a fum at that time egregious. His cavilling difpofition how- ever made him unhappy in himfelf, and defpi- cable to moll: of the learned y and after pub- lilhing- his fyftem, he feems to have entirely thrown up anatomy from his 29th year; being then called to the ferviee of the imperial court and army, in which he made an excellent fur- geon. He is faid to have ended his life un- timely, in a voyage to Jerufalem, 1564, either devotional or penal. In his great v/ork [de cor<~ pons htimain fabricdy fol. Bafil. apud Oporin. 1543, & 1555.) lib. 1. he gives us an excellent •ofteology, freed from the miflakes and abfur- dities of Galen, whofe errors he feverely re- futes, illufirated with neat and ftrong figures, drawn and cut with great art. In his fecond book he gives us 18 tables of the mufcles, of which the firfi:, fecond, third, and fourth, re- prefent the ftrong life, and have therefore been ufually followed, as models for painters, &cv His defcriptions are alfo much more minute than had as yet been given; but excelling as they both are, they have notwithftanding their faults, in great numbers. In his fixth book he has reftored the true figures and fituations of the mediaftinum, pericardium, and heart, ■conformable to their natural appearances in the human body ; which till then had been cor# rupted by his predeceflbrs, in copying fio^ d 2 - . brutes: lii Prcgrefi of Phyfiology brutes. His figures of the brain are the firfi: that can bear infpedion. He is the firft that figured and defcribed the valvula pylori, with the fpinal lymphatic glandules behind the oefo- phagus, and the epiploidal or fat appendices of the colon. It muft yet be owned, that the courfe of the arteries and veins, as figured to us by Vefalius, and copied by his fucceflbrs, are as defeftive as any part in his book ; and fall infi- nitely Ihort of the Euftachian accuracy. The fame may be faid of him in refpedt to the geni- tals of the female, which he copies chiefly from brutes, as well as the kidneys. His dif- fedtions of the eye, are from cattle ; and his perfeverance in alTerting a feventh mufcle that is in them, to be alfo in the human eye, after being admonifhed by Fallopius, is both obftinate and egregious ; as is alfo his denial of the optic or blind pore in the nerves, &c. §. XVI. Barthol. Euftachio flourilhed as public profefihr at Rome, cotemporary with Vefalius, and has well merited the title of the prince of anatomifts, both ancient and modern. He learnedly refcues Galen from many wrong and malignant accufations of Vefalius, and fliows his defcriptions were of the human, and not of the monkey Ikeleton ; but in fome places is himfelf culpable of vindicating a falfity. He firfl; defcribes the tube, called after his name, with the bone fhapes ; and in treating of the teeth, he has almofl: quite exhauflied the fubjedt, and given us a fair fpecimen, how com pleat a fyfiem we might have expedted from -him, ,had he been healthy and able to have gone < through and of Medicine '. liii through it. In his pofthumous tables, which will ever remain the mafter* piece, betwixt an- cient and modern anatomy, he gives figures of ikeletons, much more corred: than thofe of Vefalius, only rather too fmooth, or from too young fubjeds ; to which he has fubjoined fe- parate views of the moll: difficult bones, from a difmounted fcull ; the multiform or fphenoidal bone is elegant, and in the upper iaw you fee the antrum afcribed to Highmore, and largely noticed by Mr. Cowper, in the fyftem of Drake. Euftachio gives us many fyllematical tables of the mufcles, truly drawn from nature, and dif- pofed according to their ftrata or lituations, from the furface to the bones of the body ; thefe he propofes as a continued critic upon the more de- fedive tables of Vefalius ; and has in many parts rivalled the fuppofed difcoveries of Mr, Cowper, and other profefled mufcular anato- mifts of the prefent age, in the face, larynx, pharynx, ear, genitals, eyes, &c. Thefe ta- bles appear to have been formed on the fame plan, and with the fame induftry ufed in the late mufcular tables of Albinus j which are finiffied in the highefi: perfedion. He not only reftores the heart to its natural and juft pofi- tion, but alfo gives an elegant view of its pro- per arteries and veins, with thofe of the lungs, and his valve at the coronary vein. tab. 15, and 16. In his figures of the encephalon and nerves, thofe of tab. 17, 18, are incomparable, , both for labour, corrednefs, and fulnefs : and; , thofe following to the 24th table, in which thj^:-^^' courfes of the nerves amongft the bones and d 3 mufcles liv Progrefi of Phyfiohgy mufcles are graphically viewed, continue the wonder of all wife anatomifls, and as yet without a fellow ; as are thofe of the blood veffels in the fame manner, while thofe of Vefalius, Willis, Vieuffens, Cowper, and others, drawn like the twigs of a tree apart from the body, are almoft a continued puzzle, either ufelefs, or but little inftrudtive. Since Euftachio excelled in the neurography, it has continued, and now re- mains the lead; finifhed of any branch of ana- tomy. He has reduced the oefophagus to its true figure and fituation, with refpetS to the larynx, trachea, fpine, and flomach } in which laft he fhows the difference of its figure, be- twixt being full and empty, the ligaments that join its cardia and pyloris, the true courfe and figure of the duodenum, colon, liver, fpleen, and pancreas j with the mefentery, in which you haye plain traces of the lymphatic or ladleal veffels, and their glands, which lead to the re- ceptacle of the chile and thoracic du6t, by him larselv defcribed in his book of the 'vnia azy- gos, or fine pari. His figures of the liver ex- cel mod: of the prefent day ; and his varieties of the urinary paffages are as elegant, as their defcriptions are exquifite ; as are alfo the parts of generation, with their blood-veflels, both male and female : for in the firft you fee the earlied: figures of the feminiferous tubuli, vefi- cles, caput and oculi galinaginis, at the neck of the urethra, corpus cavernofum, &c. His tab. 14. and 15. on the female genitals, fhow adonifhing indudry : for here you have the cli- toris and its mufcles, the fphinder, vaginae, hymen. and of Medicine, Iv hymen, and vafa uteri in their perfedllon ; with the communicant vefTels of the round liga- ments, uterine tubes, ovaries, &c. He fliows the uriniferous du£ts and their papillae, open into the pelvis ; which laft he gives in its true fizc and fituation, to correfl what Vefalius had given us from brutes : the oblique entrance of the ureters into the bladder, without valves ; the fituation of the right kidney, lower than the left, to corredf the oppofite and current error ; and proves by ligature on the ureters, no urine can enter the bladder but through them. His exquifite figures of vefiels throughout the body, are fuch as prove him to be acquainted with feve- ral forts of injedfions j as he in fome meafure in-r deed owns, by declaring water may be urged from the renal blood-veflels, into the pelvis and uretur. In tab. 39 and 40. you have an ele- gant difledtion of the human eye, with all its parts ; to corredt the mifleading cuts given by Vefalius, from cattle. His defcriptions of theor- gans of hearing, are equally well known, as they are perfedt. But his elegant plates lay loft to us ’^till about 40 years pafi: ; and have had no fignificant explanation, ’till one w'as lately given by his laudable imitator, Albinus. §. XVII. But to come nearer home, in the midft of the unlearned 13th century, flourifhed in the univerfity of Oxford, Roger Bacon, a francifcan, and fellow of Merton college, who by great ingenuity and experimental labours, penetrated not only into phyfic, but alfo the principal inftruments and operations of che-» mhlry, optics, and mechanics, to a degree that d 4 fo Ivi Progrefs of Ph^fiohgy fo far furprized the more philofophic part of the Vv^orldj that they univerfally gave him the title of Dr. Mirabilis; while the more ignorant and fuperftitious part cenfured him for. a diabo- lical conjurer, and by malicious accufations, procured him great troubles from his fuperiours, who were too eafily milled in his prejudice. After he had been cited for necromancy to the holy fee, by the fuperiour of his order, al- though he cleared himfelf by a profeffed treatife (de nullitate magise), his companions of the college always continued fo jealous of him, as to intercept every body from his converfa- tlon, and would allow his books no place in their libraries. Thefe and other difficulties, brought on him by the difclofure of fome furprizing experiments, unknown to the day, made him doubtlefs more referved in what he afterwards communicated by his writings ; concerning chemical experiments, burning-glaffies, gun- powder, mathematical inflruments, and optical lenfes, applied in the way of microfeope, te- ' lefcope, or magic-lantborn, &c. Wherein he fliows himfelf to have anticipated his country in philofophic learning by feveral ag|s, in thofe of his manuferipts, which make a choice part in the Bodleian library of Oxford. See Dr. Plot. Hift. Ox. c. 9. Freind’s Hift. of phylic. vol. 2. Father Bacon laments the unlearned flate of the clergy, univerfally feen in his day ; and obferves, there were but three or four whom he knew meritorious of the title, wife, pf. learned inffiu’rope, among whom he reckon^ ^ ViF and of Medicine, Ivii Villanova, whofe works were public at Lyons, fol. 1520 j and Dom. de Garbo, whom he terms the doctor of experiments ; and has left us a treatife de Casna & Prandio. Rome, 1545. fol. §. XVIII. From the time of the good friar, mechanical and experimental knowledge, which lay the only true bafis of medicine, made very inconfiderable advances j ’till towards the clofe of the lixteenth age, an illuftrious lord chan- cellor of the fame name, arofe as the great lu- minary, no lefs of philofophy, than of law to England. This great man firll boldly declared among us, that though he ought always to fpeak honourably of Ariftotle, yet he muft in the main condemn his philofophy, as a bundle of infignificant and difputable notions, pro- ductive of no manner of benefits to human life: which he afterwards made appear by his own labours, in fhowing the difference betwixt fpe- culative and experimental knowledge in phi- lofophy. Lord Bacon was born, fon to chan- cellor Nicolas Bacon, at York-houfe, in the Strand, 1560, and was from his infancy re- markable for quicknefs of wit, and depth of penetration. Although he had been 19 years chancellor, he died at lafl fubfifting on chari- ty, at the earl of Arundel’s, High-gate, 1626; and was buried at St. Michael’s, near St. Al- ban’s, from which town he had his title of baron. The additions made to the fciences, as well as to phyfic and philofophy, by this great man, are too numerous and well known for u&r Iviii P>'Ogr-efs tf Phyjiology to infift upon here, fince his learned and exten- five works are now become a material part in every good library. But his Atlantis^ defcribing a collegiate body of wife men, labouring each in their way to promote natural knowledge, is the more remarkable, as it excited the learned, and gave birth not only to our royal fociety, but to all the like academies of Europe j in which learning has by their means been fince raifed to the higheft points of perfediion. While lord Bacon was improving experimental know- ledge in England, the like works were carried on by Gallileo in Italy, whofefcholar Torricelli invented the barometer ; and by the difquifi- tions of fvlerfennus, in France: but as for M. des Cartes, in the Low- Countries, his nobility and mathematics only ferved to make him more infamous as a philofopher ; fince deferr- ing the rule of plain reafon and jufi: experi- ment, by which he propofed to ered his fyftem, he has only buried himfelf and his fol- lowers in a cloud of idle abfurdities, that too long blinded moft of his French neighbours, to the light of a better philofophy. Gallileo was native of Florence, profeffor at Pifa, and aftro- nomer to the grand- duke de Medicis ; after whofe name, he called the fubfidiary little moons that he difcovered, revolving about Ju- piter, Satellites Medicei. After the ice had been once broken up by lord Bacon, many able heads and hands cheerfully fucceeded him in extending and clearing the channels of Icience; ■gmong whom the honourable Mr. Pvobert end of Medicine, lix Boyle, and fir Ifaac Newton appear the earlieft and mofl: confpicuous upon the lifl: : infomuch, that at this day, a philofopher is faid to be no where able to make a better repaft, than from a difh of old Englifli Bacon, well Boyled, and carved out by Newton. The advantages that have enfued from the mechanical philofophy of this lafi: gentleman, in all arts, fcienccs, and occupations of life through Europe, before and after the clofe of the lafi; age, would alone fill a very large volume; and fince Dr. Keill and others have in a feries of fifty years paft brought down his fyftem by experimental courfes, to be the plain objedt of our fenfes, no lefs than ^ of our intelled:ual reafonings, the ftudy of his * philofophy is become equally a pleafing amufe- ment, as an improving inftrudtion, even to the weakeft ages and fexes. §. XIX. But our own profeflion has of late years received no lefs improvements, than philofophy herfelf. For while the lafi; was advantageoufly laid out upon the anvil, by lord Bacon, a man equally great in the line of iEf-^ culapius, ftruck a new and unextinguifhable light to phyfic in all her branches ; by ena- bling us to underftand the manner, operations, and effedls of the circulation of the blood ; the main fpring of all the various motions in the living body, and the only key to all the changes that can happen in it, either under the in- fluences of health, aliments, medicines, or dif- eafes. This important difeovery, after it had; been fome years made, privately taught, and by Ix Prcgrefs of Fhyjiology degrees cleared up, by the great Dr. Williatn Harvey was afterwards publi(hed to the world, by a printed treatife in the year 1628, Our Britifh Hippocrates, who pulled off the blind-fold from phyfic, was born at Foikefton in Kent 1576, was afterwards fcholar m Dr. Cajus’s * Ndw as the Harveian doSrine of the circulation (§.. XIX.), is the grand rule by which the knowledge and pradlice of phyficians in general muft be raifed, fquared, and modelled, through all future ages and nations ; and as it is alone the true light that can guide us fafely and fen- fibly through the whole phyfiological and nofological clue of medicine : w'e may prefume, that no lover of truth and (mankind, will be difpleafed to fee here a tranfcript of fo many of the great author’s own words, as will fuffice to give us a plain view of his difcovered circulation of the blood, through the heart and extreme parts of the body; which with fome other collateral hints, of great impor- tance, have fince furniflied a large part to this compen- dium, as we Aiall point out by occafional references to the fedions ; which will give a further explanation of each article. ——After offering his enquiries for the public good, to the candid reception of his royal mailer, Charles I. whom he falutes as the true heart of his people ; from whence the vital ftreams of truth, honour, jullice, clemency, liberty, and property mull flow through all conliderable members, to the mutual happinefs of himfelf, and downward even to the leaf! individuals in the Britilh conflitution ; he then b.ecfins by telling us the motives for putting the prefs to the labour of fweatmg in his writings. Circulaiio Harviana. I. Cum raultis vivorum diflecTlionibus animuni ad ob- fervandum primum appuli, quo cordis motus ufum & uti- litates in animaiibus per autopfiam, & non per libros in- venirem; plane rem arduam reperi, ut motum cordis foli Deo cotTnitum effe, poene opinarer. Tandem majori -mdies, & difquihtione, & diligentia ufus, multa viva .n- tfo^fpidendo, multifque obfervationibus collatis, reni atti- .^iile, & ex hoc labyrintho me extricatum evafifie, fimulque motum. and of Medicine, Ixi Cajus’s coHege, Cambridge, from whence he went out dodior, after having hrft fpent about five years in the anatomical and medical empo- rium of that day, Padua, in Italy. After fome pradice, his merits appeared in the great judgment of Charles I. fufficient to entitle him the Circulatio Harviana. rnotutn, & ufum cordis, & arteriarum, quern defidera- bam, comperturn habere ms exiftimabam. Ex quo non folum privatim amicis, fed etiam publics in prseleAonibus meis Anatomicis, Academico more, proponere fenrentiam nonverebar. Tandem amicorum precibus, partim etiam aliorum per motus invidia,hasc typis mandare publicecoaAus fui. viz. an. 1628. lam denique noflram de 'circuitu fanguinis fententiam ferre, & omnibus proponere. liceat. 2. Primum itaqua aperto pedtore, & difledta capfula, .cor immediate, obfervare licet, Cor aliquando moveri, ali- quando quiefcere ; elTe etiam tempos in quo movetur, & in quo motu deftituitur. In quiete, ut, in morte, cor laxum, fiaccidum, jacet : In motu, erigatur cor, & in tnfacronem fe furfum elevet ; fic uf illo tempore ferire. Undique contrabi, magis vero fecundum latera, ita ut, & longiufculum, & colledum appareat. Ex his mihi videi- batur manifeftum j motum cordis elTe fecundum dudtum omnium fibrarum conftridtionem ; fecundum ventriculosco- ardlari, & contentumfanguinem protrudere; &eodem tem- pore pulfus forinfecus fentitur & contenti fanguinis protrufio cum impetu a conftridtione ventriculorum. Neque ve- rum eft, quod cor extentionefanguinem in ventrieulos attra- here, fed dum laxatur & ooncidit, fanguinem ab auriculis re- cipere. 3. Eo tempore quo cordis fit Syftole, (i .). arteriae dila- tantur, pulfum edunt, & in fua funr Diaftole. (2.) Quando finifter ventriculus cefiat ccntrahi, cefiat pulfus arteriarum. (3.) Item fedla quavis arteria vel perforata, in ipfa fyftole ' ventriculi finiftri propellitur foras fanguis ex vulnere cum impetu. j-Ex his manifeftum, quod arteriarum Diadole fiat eo tempore, quo cordis. fyftole. Denique arteriar- rum pulfum fieri ab impulfu fanguinis e ventriculo finiftro, ■ ■ ' quo & pulfum semulari, five fint majores, vehementio;rei^-'^ • Irequentes, celeres \ omnes enim rhythmum, quantitafr^' 1x1$ Progrefs of Phyfdlogy the guardian of his health; and during the fuf- ferings of that prince, the dodlor’s perfon, writings, and eftates, bore proportionably a large (hare. His great genius at invention, and his anatomical fkill, were not limited to the heart and generation only ; but equally ex- tended Circulatio Harviana, $i ordinem fervant cordis pulfantis. Quare pulfus arteria- rum, nil nifi impulfus fit fanguinis in arterias. 4. Praster haec obfervanda funt quae ad auricularum ufum fpeiSant, quorum duo funt auricularum, ventriculorum duo. Qi^iatuor funt motus, loco, non vero tempore, diftin£ti. Simul enim ambae auriculs moventur, & fimul ambo ventriculi. Duo funt motusj unus auricularum, alter ventriculorum : qui fimul non Hunt ; fed praecedit motus auricularum, & fubfequitur cordis ; ut motus ab au- riculis incipere, & in ventriculos progredi videatur, * Cum jam languidiora omnia, emoriente corde, inter hos duos motus, tempus aliquod quietis intercedit.— — — Sic prius definit cor pulfare quam auriculae, ut auriculae fupervivere dicantur; primus omnium definit pulfare finifter ventri- culus, deinde ejus auricula, demum dexter ventriculus, ul- timo (reliquis celfantibus ultimo) in dextra auricula vita rc- manere videatur.- Dum fenfim emoritur cor, videre licet, poft duas vel tres pulfationes auricularum, aliquando cor unum 'pulfum lente & aegre peragere & moliri. Ut hinc pateat quod in ventriculos fanguis ingrediatur, non attra£lione, aut extenrione cordis, fed pulfu auricularum immilTus. Sed & prater haec aliquoties a me obferva- tum fuit (poftquam cor ipfum, & ejus auricula etiam dex- tra, a pulfatione quad mortis articulo quiefcerent) in ipfo fanguine qui in dextra auricula eontinetur, obfcurum mo- tum, & undationem, ac palpitationem fuperfuilTe, tamdiu, quam calore imbui videretur. Tale quiddam eviden- tiflime, intra feptem dies ab incubatione, in ovo, cernitur. In eft primum ante omnia gutta fanguinis, quae palpitat ex qua incremento fadlo, fiunt cordis auriculae ; quibus pul- fantibus, perpetuo ineft vita. Turn etiam cordis corpus procreatur ; fed per aliquod tempus albidum apparet & f^xangue, & immotum. Quinetiam in feetu humano vidi, circa and of Medicine. Ixiii tended through the reft of the human fabric, that fell under his ledlures, in the royal college of London, to which he was a liberal bene- fador. But the rebellious devaftations under his poor mafter, were here equally unmerciful to the learned, as they had been to the political world ; Circulatio Harvtana. circa pfirtcipium tertii menfis, fimiliter cof foi'matum, fed albidum & exangue, cujus tamen auriculis fanguis inerat uberrimus & purpureus. Unde auriculum, prius quam cor ipfum vivere, & poll etiam emori. 5. Ego ex his tandem & hujufmodi obfervationibus re** pertum iri confido, motum cordis ad hunc modum fieri. * Primum f'efe contrahit auricula, fanguinem conten- tum, in ventriculum conjicit ; . quo repleto, cor fefe eri- gens, contrahit ventriculos, & pulfum facit: quo fangui- nem continenter protrudit in arterias ; dexter ventriculus in pulmones per vas illud, quod revera, & conftitutione & officio, h in omnibus arteria eft; finifter ventriculus in aortam, & per arterias in univerfum corpus. In iftis cor- dis motibus, fit portionis fanguinis e venis in arterias tra- dudlio, & exaudiri in peftore contingit. Motus itaque & adlio cordis eft ipfa fanguinis transfufio, & in extrema ufque, mediantibus arteriis, propulfio ; ut pulfus, quern nos fentimus in arteriis, nil nifi fanguinis a corde impulfus fit. Quibus viis fanguis, e vena cava in arterias, vel e dextra ventriculo cordis in finiftrum deferatur. Fiftulam five arteriam, vel arterise analogon, aperte tranfmittere, turn vifu, turn fefta arteria (exinde fanguine fingula puifa- tione cordis profiliente) oculis palam confirmari pofle con- ftat. Uti ex autopfia eodem modo e venis in arterias fanguinem pulfu cordis traduej, palam eft : quje via tarn patens, aperta & manifefta, ut nulla difficultas, nullus hae- fitandi fit locus. 6. Hue ufque de transfufione fanguinis e venis in arte-? rias, & de viis per quas pertranfeat, & quomodo pulfu cordis, tranfmittatur difpenfeturque. Nunc vero, de co- pia & proventu iftius cum dixero ; adeo nova erunt & in- audita, ut verear, ne habeam inirnieos omnes homines.^' Taqtum confuetudo, aqt femel ijnbibi'ta doiSIrina — — Aniv*>' madver;f\>i Ixiv Progrefs of Phyfahgy world j fince, as the dodor affures us, they^ broke into his apartments during his abfence, and deflroyed thofe written fruits of his long labours and ifudies, that ought to have ren- dered perpetual honours to his immortal name, and fervices to all pofterity. However, wha€ he Circulatia Harviana, madverti tandem, venas inanitas & omnino exhauftas, & arterias ex altera parte, nimia fanguinis intrufione, difrup- ^as fore ; nifi fanguis aliqua via ex arteriis denuo in venaa renrearet, & ad cordis dextrum ventriculum regrederetur : unde coepi egomet mecum cogitare, an motionem quaii in circulo haberet : quam poftea veram efle reperi, & fan- guinem, e corde per arterias, in habitum corporis & omnes partes, protrudi & impelli, a finiftri cordis ventriculi pulfu (quemadmodum in pulmones) & rurfus per ve'' las in ve- nam cavam, & ufque ad auriculam dextram renrreare ; que- madmodum ex pulmonibus ad finiftrum ventriculum, ut ante diffum eft. Q^iem motum circularem eo pafto no- minare liceat. Sic contingit in corpore, partes omnes fanguine calido fpirituofo(& ut dicam) alimentativo nutriri, foveri, vegetari ; in partibus fanguinem refrigerari, coagu- lari, & quafi effcetum redJi ; inde ad principium, videlicet cor, tanquam ad fontem reverti ; ibi calore natural!, po- tent!, fervido, denuo colliquari ; 5c fpiritibus praegnantem, inde rurfus in omnes partes difpenfari. Ita cor princi- pium vitae 5c Sol microcofmi appellari meretur, cujus virtute 5c pulfu fanguis movetur, perficitur, vegetatur, 5c a cor- ruptione 5c grumefadtione vindicatur, toti corpori funda- mentum vitse, audlor omnium. His pofitis, fanguinem circumire, revolvi, propelli 5c remeare, a corde in cxtre- mitates, 5c inde in cor rurfus, 5c fic quafi circularem mo- tum peragere, manifeftum puto. Supponamus quan- tum fanguinis finifter ventriculus in dilatatione (quum re- pletus frc) contineat ; ego in mortuo reperi ultra ^ ij. Supponamus firhiliter, quanto fefe contrahit cor tanto mi- nus continere, atque inde quantum fangnnis in arteriam magnam protrudatur : (protruditur in Syllole enim aliquid femper, ex fabrica valvularum) verifimili conjedfura ponere licet, in arteriam immitti partem quartam ; ita in homine protrudi, and of Medicine. Ixv he has divulged upon the circulation through the heart, and the bufinefs of generation, are enough to fhow us the depths of his penetra- tion, and the diligence of enquiry with which he always traced the fteps of nature, in every part of the body j as alfo of the ingenuity of his re- Circulatlo Harviana. protrudi, fingulis cordis pulfibus, fupponamus ^ £ fangui- nis, qui, propter impedimentum valvularum, in cor re- meare non poteft. Cor una femihora plus quam mille pulfus facit ; imo in aliquibus, & aliquando bis, ter, vel quater mille. Jam multiplicatis drachmis, videbis una femibora talem proportionatam quantitatem fanguinis, per cor in arterias transfufam j quas major eft copia quam in univerfo corpore contingat reperiri. Similiter, in ove, aut cane, plerumque non continetur plus quatuor libris fangui- nis ; quod in ove expertus fum. In quavis propulfione proportio fanguinis exclufi debet refpondere quantitati prius contentae, & in dilatatione replenti ; uti in contradlione nunquam nihil vel imaginarium expellit, fed femper aliquid fe- cundum proportionem contraftionis. Quare concludendum, fi uno pulfu in homine, cor emittat ^ 15, & mille fiant pul- fus in una femihora, ccntingere eodem tempore, libras Ih xlj, & ^ viij, (ft ^j, lb Ixxxiij & ^ iiij) contingere in una femihora transfufas (inquam) efle de venis in arterias. Interiam hoc fcio, & omnes admonitos velim, quod ali- quando ubericri copia pertranftt fanguis, aliquando mi- nore ; & fanguinis circuitus quandoque citius, quandoque tardius peragitur, fecundum temperamentum, aetatem, caufas externas & internas, & res naturales & non natura- les, fomnum, quietem, vi6tum, exercitia, animi pathe- niata, & fimilia. Arterias autem nullibi faoguinem e venis recipere, nift tranfmiffione faifa per cccr, ex ante diftis, patet. Quare, iigando aortam ad raditem cordis, & aperiendo jugularem, vel aliam arteriam, ft arterias ina- nitas & folum venas repletas confpexe'ris, mirari non con- venit. Hinc caufam aperte videbis, ' cur . in Anatome tantiim fanguinis rcperiatur in venis, parum veto in arteriis j cur multum in dextro ventriculo, parum in ftniilro; caufa forfan eft, quod de venis in arterias nullibi datur tranfttu^" VoL. I, e . , t ■ . ni$ Ixvi Progrefi of Phyficlogy reflections in deducing their phyfiological and practical ufes. As his great difcoveries and doctrines of the circulation appeared plainly deftru6tive of the whole foundation and fabric of medical theory, as it then flood tottering on the fancies of Ariflotle and Galen j it accord- ingly Circulatto Harviana. nifi per cor ipfum & per pulmones. Prseterea hinc pa- tet, quo magis, aut vebementius arteriae pulfant, eo ci- tius, in omni fanguinis hoemorrhagia, inanicum, iri, cor- pus. Hinc etiam in omni lipothymia, omni timore & hujufmodi, quando cor languidius & infirmius, nullo im- pctu pulfat, omnem contingit hcemorrhagiam fedari & co- hiberi. Hinc etiam eft, quod corpore mortuo, poft- quam cor cefliivit pulfare, non poftit, vel e jugularibus, vel cruralibus venis & arteriis apertis, ullo conatu, maflaE fanguineae plus quam pars media elici. Nec lanio, ft bovi jugulum prius fecuerit, totum fanguinem exhaurire inde poterit. Hinc omnis tumoris caufa (ut eft apud Av'icen.'\ 5c omnis redundantiae opprimentis in parte ; quia vias in- grcffus apertae, egreflus claufae, inde humorem abundare, 5c in tumorem partem attolli necefle eft. Hinc etiam contingat, quod, quoufque tumor incrementum capefcit,. Ego e curru delapfus aliquantum, frontc percufTus, quo loco arteriie ramulus e temporibus prorepit, ftatim ab ipfa per- cuftione, fpatio fere viginti pulfationum, tumorem ovi magnitudine, abfque vel calore vel multo dolore, paflus fum; propter videlicet arteriae vicinitatem, in locum con- tulum, fanguis, afFatim magis 5c velocius, impingebatur. Hincapparet, qua de caufa phlebotomia, fupra feflio- ncm ligamus, non infra ; quia per arterias impellitur in ve- nas, in quibus regreftus per ligaturam prsepeditur, ideo ve- nae turgent^ 5i diftentas impetu per orificium ejicere pof- funt ; foluta vero ligatura, viaque regrelTus aperta, ecce fanguis non ampliiis, nifi guttatim decidit : 5c quod omnes norunt ; fi vel vinculum folveris vel ftridte nimis Conftrin.xeris, turn non exit, quia fcilicet via, ingreftus 5c m.ftuxus fanguinis per arterias, intercepta eft ftriefa iila li- gatura; aut regreftus liberior datur, per venas, ligatura folata.-— -Aniplius obfervandum , quoJ in adminiftranda pble- and of Medicine. Ixvli ingly Toon met with violent oppofitions from the pens of feveral (otherwife learned and judi- cious) prbfelTors, who thought it but right, re- ligioufly to proftitute their fenfe and reafon to the blind authorities of thofe fathers. Thus Riolan, and others at home, as well as abroad, flood Circulatlo Harvlana. phlebotomia quandoque contingat, hanc veritatem confir“ mari. Nam, redte brachium quanquam ligaveris, & fcal- pello debito modo diffecueris, apto orificio & omnibus rite adminiftratis ; tamen fi timer, aut quaevis alia caufa, aut animi pathema lipopfyehia adveniat, ut cor languidius pul- fet, nullo modo fanguis exibit, nifi guttatim : prsefertim II ligatura ftriftior paulo fafla fit. Ratio eft, quia com- prelTam arteriam languidor pulfus & impellens vis infirmior recludere & fanguinem infra ligaturam trudere non valet : imo per pulmones deducere, aut e venis in arterias copiofe transferre, enervatum & languidem cor non poteft. Sic eodem modo, & eifdem de caufis contingit mulierum men- ftrua, & omnem hsemorrbagiam fedari. Ex contrariis etiam hoc patet ; quoniam, redintegrato animo, amoto metu, cum ad fe redeunt, jam adaudlo robore pulfificante, arterias ftatim vehementius pulfare (etiam in parte ligata) in carpo moveri, & fanguinem per orificium longius prolilire, continuo videbitur. [V. Le ctatem, aut denfitatem fubftantiae : fed rarius fiunt pulfatio- nes, & quandoque omnino non, ob frigiditatem. Hoc etiam infedlis videtur contingere, cum hyeme lateant, vel plantae vitam tantummodo agant : fed an idem etiam qui- bufdam fanguineis animalibus accidat, ut ranis, teftiidini- bus, ferpentibus, hirundinibus, non injuria dubitare licet. Unde & veriftimum iilud {Arijlot. de part, animal. 3,) quod nullum fanguineum animal careat corde. Sic quibuf- cunque infunt pulmones, illis duo ventriculi cordis, dexter &linifter; & ubicunque dexter, ibi fmifter quoque ineft; nbn e contra. Cum fpongiofi, rari & molles lint ipfis pulmones, ad protrufionem fanguinis per ipfos vim tantam non defiderant ; proinde in dextro ventriculo fibre, pau- ciores & infirmiorts, nec ita carnofse, aut mufculos smu- lantes: in finiftro vero funt robuftiores & plures, carno- ftores & mufculofi ; quia fmifter ventriculus majori robore & vi opus habet, quo per univerfum corpus longius fan- gikinem profequi debet. Hinc etiam medium cordis poffi- det, & triplo craffiorem parietem & robuftior eft finiller ventriculus dextro. Hmc omnia animalia, etiam homines, quo denfiori, duriori & folidiori habitu funt carnis, eo ma- gis fibrofum, craffum, robuftum & mufculofum habent cor. IQ, V^Ivul4rum fiiniliter ufumconfidera ; quae ideo faCia;, e 4 'i' • . na % Ixxii Progrefi of Phyjiology the foie rules to guide his difquifitions. Thus if it be plain, that Hippocrates and fome others have known and declared, that there was both a circulation and a perfpiration throughout the body ; ’tis equally evident, from their writings, that they neither knew' the antecedent caufes, the Circulatlo Harvlana. ne femul emifius fanguis in cordis ventriculos regeratur. Differentia ventriculorum incipit in robore, quia dexter duntaxat per pulmones, finifter per totam corpus inipellit. In aliquibus hominibus, torofis videlicet & durioris habitus, dextram auiiculam ita robuftam, & cum hcertu- lis & vario fibrarum contextu intius affabre concinnatam reperi ; ut aliorum ventriculis robore videretur squipol- Jere : & mirabar fane quod in hominibus diverus, tanta effet differentia. Sed notandum, quod in foetu auriculae longe majures, quam pro proporticne infunt j quia, ante- quam cor fiat, aut fuam fundfionem praeflet, (ut ante de- monftratum eft) cordis quafi officium fadunt. Primum, dum foetus, quafi vermiculus mollis, ineft folum pundum fanguirieum, five veficula pulDns, & urabilicalis venae por- tio, ja principio vcl bafi dilatata ; pcftea cum foetus deli- neatus, ifta vehca carnofior &; robuftior fada in auriculas tranfit, fuper quas cordis corpus pullulare incipit, nondum nllum ofHcium faciens publicum : formato veto fcstu, cum jam diftinda olfd a carnibus font, S: perfeclum elf animal & motu.m habere fentitur, turn cor quoque, intus pulfans habetur, & (ut dixi} utroque ventriculo fanguinem e vena cava in arteriam transfunoit. Sic natura divina, cor ad- didit gradibus, tranuens per omnium animalium conftitutio- nes ut ita dicam, ovum, vermem, fcetum, he. Arteriae in fua tunicarum craftitie h robore tantum a venis difFerant, quia fuifinent impetum impcilentis cordis & proruinpentis fan- guinis. Hinc, cum natura perfeda nihil tacit fruffra, & in omnibus he fufiiciens ; quanto arteriae propinquiores cordi funt, tanto migis a venis in conftitutione dlfferunt, A, robuUiores funt & iigamentofe magis ; in uitimis vero dilTeminationibus ipUrum, ut manu, pede, cerebro, mefen- terio, fper;iiaticis, ita conftitutione hm.les funt, ut oculari tunicarum infpedione, alterum ab altero internofcerc diffi- cile J and of Medicine. Ixxlii the modes of operation, nor the immediate effedts of them j which, as Dr. Pitcairn has, in his vindications, amply and elegantly proved, make the eifential parts of every fcientifical dif- covery. §. XIX. The publication of Dr. Harvey’s great difcovery to the world, foon excited a fpirit Circidatio Harviana. cile fit. Hoc autem juftis de caufis fic fe habet ; nam quo longius arterise diftant a corde, eo minore muito vi, i£tu cordis per multum fpacium refrafto, percutiuntur. Ad- de, quod cordis impulfus, cum in omnibus arteriarum, truncis & ramulis fufficiens fanguini effe debeat, ad divifio- nes finguias quafi partitus imminuitur ; adeo ut ultimae di- viliones capillares arteriofe videantur venae, non folum coniTitutione, led & officio & fenlibilem pulfum aut nullum aut non femper edant, nili cum pulfat cor vehementius, aut arteriola in quavis particula dilatata aut aperta magis eft Inde fit ut in dentibus quandoque & tuberculis, quan- doque in digitis fentire pulfum poffimus, quandoque non. Unde puercs (quibus pulfus femper funt celeres & fre- quentes) hoc uno figno febricitare certo obfervavi ; & fimi- liter in tenellis & delicatulis, ex compreffione digitorunx, quando febris in vigore eftet, facile ex pulfu digitorum percipere potui. Ex altera parte, quando cor languidius pulfat, non folum, non in digitis, fed nec in carpo aut temporibus pulfum fentire contingit, ut in lipothymia, hyftericis fymptomatibus, afphyxia, debilioribus & mori- turis. Eodem modo in pulfuum fpeculatione ; cur vide- licet ifti lethales, aut contra ; & in omnibus generibus, ipforum caufas & prsfagia contemplando, quid ifti fignifi- cent, quid hi, & quare. Simdlter in crifibus & expur- gationibus naturae, in nutritione, praefertim diftributione, alimenti, limiliter & omni fluxione. — Denique in omni parte medicinae, Phyfiologica, Patholosica, Semeiotica, Therapeutica, cum quot problemata determ'nari poffint ex hac data veritaCe St luce ; quanta dubia foivi & quot ob- fcura dilucidari, animo mecum reputo, campum invenio fpatiofiffimum, ubi longius percurrere & latius expatiari adeo polTum, ut non folurn in vokmien excrefceret, praeter ‘ . inftitutum Ixxlv Progrefs of Phy/iokgy fpirit of emulation, and employed all the Euro- pean profelTors of anatomy, to trace the heps thereof, both in living and dead fubjeds ; and in both to examine all parts with more labour and care than they were hitherto ufed to be- flow : the confequences of which were, very confi- Clrculatlo Harviana. inftitutum meum, hoc opus, fed mihi forfan vita ad finem faciendum deficeret. II. Quantum pulmones in textura & mollitie, ab ha- bitu corporis & carnis recedunt, tantum difFert venje arteriofae tunica, ab aortas. Semper base omnia ubique proportionem fervant, in hominibus : quanto enim ma» gis torofi, mufculofi & durioris fint habitus, & cor ha- beant robuftum, craflum, denfum & fibrofum magis, tanto auriculas & arterias proportionabiliter in omnibus, craffitie & robore habent magis refpondentes. Hinc qui- bus animalibus, leves ventriculi cordis intus funt, abfquc villis aut valvulis, & pariete tenuiore (ut pifeibus, avibus, feipemibus H quam pluribus generibus animalium) in illis arteriae parum aut nihil a venis differunt in tunicarum craflitie, Amplius, pulmones tarn ampla habent vafa, ve- nam & arteriam, ut truncus arteriae excedat utrofque ra- mos crurales & jugularts ; caufa ell, quia in pulmonibus S: corde promptuarium, fons & thefaurus fanguinis & offi- cina perfeftionis eft. Vita ig'ttur in fa7iguiuc conjijiit, (uti etiam in facris nojlris legimus). Crebra enim (ut dixi) vivorum dill'eiftione expertus fum, moriente jam animali, nec amplius fpirante, cor tamen aliquandiu pulfare, vitam- que in fe retincre. Q^uefeente autecn corde, motum vi- deas ill apiiuilis fuperllitem, ac poftremb in auricula dex- tra ; ib que tandem ceii^nte omni pulfatiope, in ipfo fan- guine undulationem quandam, & obfeuram trepidationem, five palpitationem (extremum vitas indicium) reperias. Et cuilibet cernere eft, fanguinem ultimo calorem in fe retine- re : quo iemel prorfus extin£lo, ut jam non amplius fan • guis ell, fed crusr ; ita nulla poftliminio ad vitam revertendi fpes rcliqua. At verd, turn in ovo, turn in moribundis animalibus-, puftquam omnis pulfnio difparuit ; ft vel pundo falienti, vd dextrie cordis auiicul^ levem fomitem admo’. cris5 videbis illico^ motum, puliaiionem, ac vitam and of Medicine. Ixxr confiderable anatomical difcoverles, of a lefler order, by different profeffors, in all quarters of Europe j according as each of them had chofen particular provinces of the human body, to be the proper objeds of their ftrider enquiries and experiments. Injections of water, milk, ink, &c. Ctrculatlo Harviana. a fanguine redintegrari ; modo is calorem omnem innatum, fpiritumque vitalem baud penitus amiferit. ^ihus dare conftat^ fangui-nem e£'e partem genitalem^ fontem vita^ pri^ mum vivens & ultimo mortem, fedemque animae primarium ; in quo (rai'quam in fonte) calor primo, & praecipue abun- dat, viiietque ; & a quo reliqua omnes totius corporis partes calore inpuente foventur, (sf vitam obtinent. Propterea^ fanguis ubique in corpore reperitur ; nee ufpiam id acu pungere, vel minimum Icalpere queas, quin fanguis ocyus profluat'. tanquam, abfque eo foret, nec calor partibus, nec vita fuperefiet, Ideoque, concentrate, fixoque leviter fanguine ( Hippocrates, f nominavit) veluti in lipotbymia, timore, frigore externo, & febrium infulta contingit ; videas illico totiim corpus frigefeere, torpere, & paliore livoreque perfufum languefcere : evo- cato autem rurfus fanguine, per adhibita fomenta, exerci- ■ tia, aut animi paffionts, (gaudium nempe, iramve) hui ? quam fubito omnia calent denuo, florent, vigent, fplen- dentque ? bine caulTas perfpicere liceat, non modo vitas, in genere, fed longioris etiam, aut brevioris aevi; fomni, vigiliarum, ingenii, roboris, &c. Nanque ejus tenuitate (ait ibid. Ariji.) iA munditie, animalia fapientiora funt, fenfumque mohiliorem obtinent : Semilitcr, vel timidiara, vel animoja ; iracunda, iA furiofa evadunt ; prout fell, fanguis torum vel diluius, vel filris multis crafijque refertus fuerit, Nec vitae folum fanguis autor eft ; fed, pro ejus vario diferimine, fanitacis etiam, morbonimque caufiae contin-’ gunt. Qinnetiam venena, quae forinfecus nobis adveniunt (ut i£ius venenati) nifi fanguinem inficerent, damnum nul- lum afFerrent. Adeb nobis ex eodem fonte, vita & fanitas profluunt. Si fanguis nimis eliquefcai (inquit Ariji.) agro- tant. Namque in cruorem ferofuni abit adeb, ut quidam fu~ 4'irem cruer^ium etgfuddrint. — ■^Arijlttteles qupque, ut fan- guinem Ixxvi Progrefs of Phyfiology &c. were firft ufed to trace the veflels, by Eufta- chio, Harvey, Highmore, Gllffon, Willis, Bartho- lin, 5cc. which were afterwards changed for fuet, or other hardening matters, by the ingenious Swammerdam j from whom his friend Ruyfch received them, and by their dexterous adminiftra- tion, Circulatlo Harvlana. gulnem alendi gratia inftitutum putavitj ita eundem etiam, veluti e partibus, comp .fitum cenfuit. Nempe ex craffi- ore, h atra, quae in fundum pelvis, inter concrefcendum, fubfidit : eaque pars illi dcterior habetur : Sanguis enim^ inquit, fi integer eji^ n bely iff dulcis faporis ejl 5 Jedy ft vtl tiaturd, vel mot bo ft vitiaiuSy atrior cernitur. Ex parte etiam fibrosa, five fibris, conliare voluit ; iifeiue demptisy (air) fanguis n^que concrejcity nequc fpijfatur. In fanguine praeterea fanlem agnovit ; Sanies, inquit, fanguis incodius ef\ aut quia nondum perc'>£iuSy out quid in feri modum di- lutus fuerit. Atque hunc figidiorem efie, ait; fbras z\x- tem partem fa^gulms terrenam elFe llatuit. Qiiapropter fanguis varie tlifcrt pat : adeo ut quibufdam is fit ferofior, tenuior, & quafi fanies, feu ichor ut in frigidioribus ; qui- bufdam verb craffior, fibrofior, & terreftrior, &c. non- nullis (vitiati fciL temperamcnti) fanguis atrior: aliis autem jnuiidts, fincerus, & floridus, qualis prsecipue confpicitur. ■— — Unde confiat, turn Medicos, turn Arifotehm, fangui- nem ex parcbus & difierentiis quadantenus fimilibus con- fiituere. Quippe priurquam coip >ris quifpiam vifu difcer- nitur, fanguis j m genitus adtus eft, palpltatque (ut Arifoiihsy ait) intra venas, pulfuquo funul quoqusverfum movetur ■, fdufque otnmutn hurnorum fp 07 fus per tctum corpus animaliun eft. Jemper, quandiu vita fervatur, fervet. Q^iir.imo ex vario iplius motu, in celeritate aut tardi'ate, vdrementia aut debilitate he. eum & irritantis injuriam, h fuventis commodum perfentifeere. manifeftum eft. Quippe fanguis, dum in corpore naturaliter fe habet, fimi* laris ubique conftitutionis apparet. Quamprimum autem extravafatur, caloremque naiivum exuit ; protinus, (ceu difiimilai-e qu'ddarnl in diverfas partes abit. Partes porib aiicC fibrofa; h denfiores (reliquarum vinculum:) alite fero- fae, qutbus coagulatus thrombus innatare foiet. Atque in and of Medicine. Ixxvii tion, with other artifices, acquired no fmall degrees of profit, andextenfive reputation ; the magnifier or microfcope, began alfo to be firfi; applied to anatomy by Dr. Harvey and by the two laft gentlemen. Dr. Harvey firfi: publifhed upon the motion of the heart and blood, at Franc- * See his obfervations on the heart of infefls. p. Ixx. fub £nem. fort, Circulatlo Harvtana. hoc ferum, fanguis tandem fere totus degenerat. Partes autem iftse non infant vivo fanguini, fed a morte foium corrupto, & jam difl'oluto. Jn calidloribus & robuftis ho- minibus alia fanguinis pars cernitur qu« ineo foras odu£lo 5c grumefcente fuperiorem locum occupans condenfatur, 5c gelatinem ex cornu cervino, feu mucaginem quandam, aut albumen ovi craffius plane refert; locumque fupremum in fanguinis difgregatione obtineat. Deinde in venre feiSlione, fanguis hujufmodi profiliens (qui plurimus abundat hominibus calidas temperaturae, robuftis, 5c torofis) lon- giore filo impetuque vehementiore (tanquam e fiphone eli- fus) exfilit: ideoque earn .calidiorem, 5c fpiritalem magis judicamus ; quemadmodum 5c' genitura foecundior, fpirici- bufque plenior aeftimatur ; quae longe, valideque ejicitur. — — DifFere quoque plurimum hanc mugaginem, ab icho- rofo Sc aquosa ilia fanguinis parte, quse (ceu reiiquis frigi- dior) aquofa 5c faniofa pars, crudior magi'fque incodfa eft, quam ut in puriorem & perfedliorem fanguinera tranfiere polHt. Quin certum eft, non modb partem, illam, fed 5c univerfum fanguinem, in faniem ichorofam corrumpi poffe. Pefolvuntur nempe in materiam, unde primo com- ponebantur ; ut fal in lixivium, unde orus eft. Similiter jn omni cachexia, fanguis emiflus copiofo fero abundat : adeb, ut interdum vix quicquam grumofi appareat, fed omnis fanguis una fanies videatur : ficut id leucophlegma- tia experimur, 5c animalibus exfanguinibus naturale eft. Virginibus cacheflicis, febrique alba laborantibus, ut reli - quo earum corpori, itajecori etiam pallidusinhaeret color; penurias fanguinis in corpore manifeftum indicium. — — Dum autem aflero, vitam primo ac principaliter in fan- guine refidere : nollem bine perperam concludi, omnem phlebotomiam effe periculofam, aut noxiam : vel, cum Vuigo, credi, quantum fanguinis detrahitur, tantundem ft- mul Ixx^viii Progrefs of Phyfiology fort, 1628; about which time, Afelli of Mi- lan, alfo publi/hed his difcovery of the ladleals in a dog. Pecquet of Paris, wrote on the re- ceptacle and dud: of the chyle (1651.), that had been defcribed before him by Eufta- chio. Bills and Jollif efpied the lymphatic veffels Clrculatia Harviana. mul vitse decedere ; quod facrse paginae, vltam la fanguinC cOnftituerint. Quotidiana enim experientia notutn eff, fanguinis miffionem effe plurimorum morborum falutare auxilium, & inter remedia univerfalia prsecipuum : utpote ejus vitium, vel abundantia, maximam morborum cater- vam conftituat ; & oportuna evacuatio, a morbis pericu- lofrffimis, morteque adeo ipsa faeae liberet. Quantum cnim fanguinis ex arte detrahitur, tantundem vitae ac falu- tis additur. Id ipfum nos Natura docuit, quam Medici fibi imitandam proponunt : haec enim, larga & critica eva- cuatione per nares, menftrua, aut hsemorrhoidas, afFedlus faepe graviffimos tollit. Ideoque adolefcentes, qui pleniore viftu utuntur, vitamque ii\ otio tranfigunt, nifi circa de- cimum oclavum, aut vicefimum aetatis annum (quo tem- pore fanguinis copia, una cum corporis incremento accu- mulari folet) aut fpontaneo per nares, vel loca inferiora effluvio ; aut aperta vena, a fanguinis onere liberentur > plerunque febribus, variolis, capitis doloribus, aliifque mor- bis & fymptomatis gravioribus periculofiflame aegrotanf. Quod refpicientes Vetcrinarii^ omnem fere jumentorum medelam a venae feflione aufpicantur. Ultimo jam ex- perimentum hoc admirabile (unde cor ipfum, membrum icilicet principialiflimum, vix fenfile appareat) non retice- bimus. Nobiliffimus Adolefcens, & illuftriflimi Vice- comitis de Montegonuro in Hibernia filius primogenitus, cum adhuc puer effet, ingens ex inlperato lapfu nadlus eft infortunium ; coftarum nempc fmiftri lateris fra£l:uram. Abfcefius fuppuratus, magnam tabi quantitatcm profudit ; faniefque diu e cavitate amplilTima manavit : uti ipfe mihi, aliifque (qui aderant) fide digni narrarunt. Is circa annum setatis fure decirruim odfavum, aut decimum nonum, per Galliam & Italiam peregrinabatur ; indeque Londinum ap- puiit. Interea vcro perampluni hiatum in peclore aper- tuta and of Medicine. Ixxi.t veflels (1650.); which had been tranfiently feen upon the liver before them, by Afelli. Wharton (1656.), Steno (1662.), and Nuck (1690.), dived into the glandules in general. Swammerdam (1664.), and de Graaf (1668.), ixamined the parts of generation } Harvey ' (1651.), Ctrculatio Harvlana. turn geftabat; adeo, ut pulmones (uti credbum eft) in eo cerncre, ac tangere liceret. Id cum fereniffimo Regi Ca~ rolo, ceu miraculum, nunciaretur ; me ftatim, ut quid rei eflet perfpicerem, ad Adolefcentem mifit. Quid faiftum ? Cum primum accederem, videremque juvenem vegetum, & afpeflu quoque, habituque corporis laudabili praeditum ; aliquid fecus, atque oportuit, nunciatum arbitrabar. Prse- mifsa autem, ut mos eft, falutatione debita, expofita- que ex mandata Regis eum adeundi caufsa; omnia illico patefecit, nudamque lateris finiftri partem mihi aperult ; ablata fcil lamelli, quam tutelae gratia adversus idlus, aliafque injurias externas, geftabat. Vidi protinus ingen- tem peftoris cavitatem, in quam facile tres meos prio- res digitos, una cum pollice immitterem : fimulque in pri- mo ejus ingreflii partem quandam carnofam protuberantem, reciprocdqueextrorfum introrfumque motu agitatam depre- hendi, manuque caute tradavi. Attonitus rei novitate, iterum iterumque exploro omnia ; &, cum diligenter fatis inveftigata eflent ; certum eram, ulcus antiquum & peram- plum (citra Medici periti auxilium) miraculi inftar, ad fani- tatem perdudtum effe, parteque interiore membrana vefti- tum, & per marginis ambitum firma cute munitum. Par- tem autem carnofam (quam ego primo intuitu, carnem aliquam luxuriantem credideram, aliique omnes pulmonis partem judicabanr) ex pulfu, ejufque differentiis, feu rhyth- mo, (utrifque manibus carpo & cordi fimul admotis) & ex refpirationis collatione plane perfpexi, non pulmonis lobum aliquem, fed cordis conum efle ; quern caro fungofa ex- (trefcens (ut in fordidis ulceribus fieri folet) exterius, muni- minis inftar, obtegebat. Concamerationem iftam, a fub- nafcentibiis ford. bus Adolefcentis famulus injeftionibus te- pidis quotidie liberabat, laminamque itnponebat; quofafto, herus fanus, & ad quselibet exercitia ac itinera promptus, tuto 5c. jucunde vitam degebat, Refponfi vice.igitur. Ado- Ixxx Progrefs of Phyfwhgy (1651.), Needham (1666.), Hoboken (i669.)> and Kerkring (167c,), the foetus, and itsapper- tinents. Gliffon illuftrated the liver ( 1654.) j Verfung (1643.), and de Graaf (1664.), the pancreas; Ruyfch (1665.), the fpleen and lymphatics; Willis ( 1664.), Vieufens (1685.), and Ridley (1695.), the brain and nerves, while Ruyfch went on with the blood-veffels. Willis (1673.'!, and Peyer ('1677.), fcrutinized the ftomach and guts; Bellini (1662.), and Mal- pighi (1666.) the kidneys; Borelli, and Lower (1669.), the heart; Highmore (1651), Schnei- der (1655.), and Cowper (1698.), the inner nares ; Briggs, the eye (1685.), and Duverney (1683.), the organs of hearing, &c. all which, with lefler difcoveries and obfervations, you will find worked up into the fyftems of the lafl age, recommended at §. XIII. although, as we have before obferved (§.XVL), you will perceive a great many of thofe fuppofed newdifcoveries, al- ready anticipated above an age before, by the great prince Ciyculatio Harviana. Adolefcentem ipfum ad fereniffimum Regem deduxi ; ut fcm admirabiiem & fingularem, propriisiple manibus iradta- ret, atque oculis intueretur : nempe, in homine vivente & vegeto, citra ullam oft'enfam, cor fefe vibrans, ventricu- lofque ejus puifantes videret, ac manu tangeret. Faftumque eft, ut fereniffimus Rex, una mecum, cor fenfu raftus pri- vatum effe agnofceret. Q^iippe adolefcens, nos ipfum tan- gere (nifi v;fu, aut cutis exterloris fenfatione) neutiquam jntciligebat. Simul, cordis ipfius motum obfervavimus ; nempe, illud in diaitole introrfum fubduci & rctrahi ; in fvftolc veto, emergere denuo 6c retrudi : herique in corde fvdoien, qqo tempore diaftole in carpo percipiebatur ; at- que proprmiti cordis motum & fundtionem, efle fyftolen : denique, Cor tunc pecftus ferirc, 6^; prominulum efie ; cum cng'tor furfuni, 6c in fe contrahicur. and of Medicine. Ixxxi prince of anatomifts, Euilachio. See §. XVL foregoing. §. XX. Thofe who defire to be ftili better critics in the anatomy and phyfioiogy of the prefent day, beyond the lengths which our pre- fent Compendium will conduct them, may confult our learned anatomifi:, Dr. Halier’s notes on Boerhaave j for the lake of form, thofe re- printed at Venice, 4m. feven vol. 1)44. & fea. to which add the eight fupplementaj volumes of Theles, intended to fupply tlaeir cerects, lately imported by Mr. Nourle. in the Strand. The learned AdveiTaria and Epiftles of that great or- nament to anatomy, and to all Italy. Morgag- ni ; the improved fyftem of Winflow, that is daily expedfed from under the care of Dr. Aftruc : the works of Albinus ane’ R.uyfch, &c. The principal writers from Elippocr tes to Har- vey may be briefly furvcAcd in the Blbliogra- phia '■'^natomica of Dr. Douglas. Lug. Bat 1727. L. Keifleri. ^ Compend Anaf. Amfl. 1750. For figures, thofe of EuftaebJo, explained by Albinus, Leids, 1-744. Thofe pompous tables, wb:Cn are by fome afcribed to "wammerdam, firfi; publifljed with a bad explanation, by Dr. Bidio and afterwards with a better, by Mr. Cowper, are fo flnelly defigned, by Lairefle, and engraved by Van Gunfl:, that the fair co- pies of them will hardly ever fail of efteem, although they fall very flaort of anatomical truth. Many of the figures are inv'erced, fa * See alfo his Oratio de incrementis anatomise in hoc fevuh XVIIi. and Geor; ii Frankii Bona nova "anatomica ■rib i’eculi inventa, 4to Heidelb. &c. • f ^ \ ,Yol. I, f . that Ixxxli Progrefs of Phyfiohgj that you cannot fee them rightly, but by look- ing at them in mirror ; as thole of the heart and lungs, tab. 22. and 24. alfo of the liver, tab. 37. The figures, no lefs than the vafcu- lar and nervous ftrudture of the vifcera, are often very vvide of nature ; fometimes fupplied from fancy, and bad preternatural figures. But the mufcles are fine, ftrong, and lively j the general fituations of the vifcera, in the venters, well reprefented, and the bones are no lefs beautiful : only as the mufcles are fadly difledt- ed or prepared, for the draughts, fo the bones are copied from bad fpecimens, fuch as are too fmooth, young, female, or unexercifed, yield- ing no juft ideas of the afperities, by which the mufcles are inferted into them. — Thofe, on the contrary, which have been given us by the great Euftachio of our age, Albinus, are every way finifhed to perfedlion, fo as to reprefent even the very diabits of the foetal and adult bones and mufcles, as in a painting : and thofe figures of the vifcera, that are now publifhing in numbers, by a very learned anatomift, au- thor of this treatife. Dr. Haller, at Gottingen, in Germany, are equally finiftied and praife- worthy ; as are alfo the plates of the gravid • womb, now in the prefs, by the ingenious Mr. Hunter. The mufcular fyftem, printed in co- lours at Paris, by M. Gautier, 1745. & feq. fall very fliort of thofe that were publiftied by CoLircelles, (icones mufculorum Capitis Leidae, J743.), which fliow us that Le Blond’s art of printing things to the life by a due mixture of tile primitive colours, red, blue and yellow, may both- and of Medicine. Ixxxiii both elegantly and ufefully be applied to anato- my j as Dr. Martin of Chelfea, has formerly fhown us in Botany. Thofe who defire truth .and cheapnefs together, can purchafe no fet of anatomical figures, equal to thofe of Euftachio and Albinus, lately publifhed by MefiT. Knap- tons, in Ludgate-ftreet ; but bad figures, like bad habits in mufic or other fciences, ought carefully to be fliuned by all learners in anato- my, as they corrupt the ideas, or fix imprefiions that are afterwards not eafily corredled, but from viewing nature herfelf, under a good pro- fefibr. w "/"''-. . ' ■ ■ ■ ’r.ij: • , ■ ^ ^ -y. . ■' , - , ' ' ■ ■ ■ -r.?-- i ;■.' ,, ... . - ■V' ■"' ’ ' ■ ■..■-■r-iB’ IS; . ; » * ' , -r* ■ • ^ * ’v\. [y.iiy. •' I K' '■' .:5r,'„0^ ; j': •-■ PHYSIOLOGIA; O R, A COURSE of LECTURES O N T H E Vl scERAL Anatomy and Living Oeconomy of the Human Body, &c. LECTURE XIV. Of the fenfe of touch and feeling. . §. 421. ^“W" H E other ufe and office of g the brain andnerves (§.401.) K befides motion is to that is, to fuffer a change from the adtions or impreffions of external bodies, and thereby excite other correfponding changes or reprefentations in the mind. We ffial], therefore, firft lead our examination to each of the fenfes in particular, and then con- fider, what is common to all of then7 j with VoL. II. ‘ B the 2 ^enfe of T’ouch, &c. the changes which follow from thence in the common fenfory and in the mind. §. 422. The fenfe of touch is underflood in a twofold manner ; for, by this term, in gene- ral, we call all changes of the nerves, arifing from heat, cold, roughnefs, fmoothnefs, weight, moiflure, drynefs, or other affedlions of exter- nal bodies, in Vv^hatever part or organ they are applied, to caufe a change. In this fenfe, the touch or feeling is afcribed to almofl all parts of the human body, to fome more, to others lefs ; for thus even pain, pleafure, hun- ger, third, anguidi, itching, and the other fenfations belong to the fenfe of feeling. §. 423. But, in a fomewhat different and more proper acceptation, the fenfe of touch is faid to be the change arifing in the mind from external bodies, applied to the fkin, more efpe- cially at the ends of the fingers. For, by the fingers, we more accurately diftinguifh the tan- gible qualities of things than by other parts of our body. 424 Indeed, this fenfe does not eafily diftinguifh any particles by the fkin, which it does not touch ; but lince the touch is niore peculiarly afcribed to the cutaneous pa- pilla3, therefore the ftrudlure of the flcin is to b6 firft defcribed. That part then, which is called the true Jkin^ is compofed of a thick cellular network, whofe fibres and plates are clofely compadled and interwove together in an intricate manner, which renders it porous, and capable of contradling or dilating. Within "this fubftance run many fmall arteries, which 3 come Senfe of 'Touchy &c. 3 come from the fubcutaneous ones, which* though neither large nor of a very great length* are yet numerous in fome parts of the Ikin, which look red as in the cheeks 5 but in other parts of the flcin, they are fewer in number. But the veins of this part arife in great num- bers from the fubcutaneous network, and the nerves likewife in the dcin are very numerous, but they vaniih or difappear fo faddenly, that it is very difficult to trace the ultimate extremi- ties of' them. Betwixt the fkin and mufcles is placed the cellular fabric, in mofb parts reple- niffied with fat, but in fgme, as the penis, red part of the lips, &c. it is empty or de- ftitute of fat. There are very few parts in the bo'dy of man, where the ficin is immediately joined to the mufcular fibres, without any re- paration by fat or cellular fubflance j but we have an instance of this in the forehead and upon the ears; and though the dartes of the tefticle has no mufcular fibres, it is not with- out the cellular fubftance. There are fome places, indeed, where tendinous fibres are in- lerted into the fkin, as in the neck, in the palms of the hands, and foies of the feet. §. 425. Throughout the whole furface of the ficin in mofl; parts of the body, but with fome difficulty, you will find it to have a rough ap- pearance after the cuticle is taken off ; but in the human body, thefe are fo obtufe, that un- lefs you underftand them to he very minute gra- nulations, they are raifed hardly any vifible height above the fxin ; but in the ends of the fingers, there are larger round papillc? feated in B 2 cavities 4 ^enfe of I’ouch, See. cavities of the cuticle, and receiving nerves very diflicultly feen ; namely, a little mount or protuberance formed of fmall vefTels, with one or more fmall nerves wrapt up together in the cellular fubflance. Thefe, in the lips and glans penis, after long maceration, appear vil- lous or down-like, and are feen moft evidently of all in the tongue, from the fabric of which, we conclude, by analogy, with refpedl to the other cutaneous papillae. §. 426. Over the furface of the fldn Is placed another covering, which is not fo liable to be injured by the air, and which coheres with the fubjacent fkin, by an infinite number of fmall bloodlefs vefiels, and by hairs which pafs through its fubflance. The outer furface of this covering, of an horny fabric, is dry, infen- fible, and not fubjedt to putrefadlion ; but being deftitute of vefiels and nerves, it appears in a particular manner wrinkled and fcaly. This is called the epidermis or cuticle^ which is perfo- rated by an infinite number of pores, fome larger for the fweat, and others fmaller for the perfpirable vapours, out of whofe dudls, ex- panded and cemented by the interpofition of a condenfed glue, the fubflance of the cuticle is probably compofed. By prefihre or burning, the cuticle grows thicker, by the addition of new plates or fcales, formed betwixt the fkin and thofe which lie outermofl ; and this is called a callus. But even naturally, in blacks, the cuticle has tw^o diftindl plates. §. iizy. The inner furface of the cuticle is snore foft and like a pulp, fomewhat like an half Senfe of Touchy &c. ^ half fluid or a concreted mucus ; whence, by macerating fome time in water, it feparates from the former, eafily in blacks and tawny moors, but more diflicultly in Europeans or white people j for the feparation follows in that part, where they differ in colour, as we alfo fee in the palate of brutes. This furface of the cuticle lies incumbent on the fldn itfelf, whofe papillae, in thofe parts Vv^here they are to be found, are received into the foft cuticular alveoli or fockets. This is commonly called rete Malpihgiamitny although it be certain, there are no perforations viflble through it, like thofe of a fleve. §. 428. That this reticular body is compofed of a humour, tranfuding from the furface of the true fldn, feems very probable. As to the fabric of the cuticle itfelf, it is obfcure ; for fince it is both call; off, or regenerated, infen- fible, and deftitute of veffels, it does not feem to belong to the organical parts of the body. Whether or no it be the outer part of the Mal- pighian mucus (§. 427.) coagulated and con- denfed by the air and by preffure, after being perforated with a number of exhaling and in- haling dudls, the mouths of which are ce- mented together by the interpofed condenfed glue ? and whether or no we are not perfuaded to this opinion by. the mucous expanflon upon the membrane of the tympanum i to which, add, the diflblution of it in water, obferved by the more eminent anatomifls ; [which experi- ment is by others denied in the cuticle of blacks.] B 3 §• 249- 6 Senfe of 7 ’ouchy See. § 429. Moreover, to the hiftory of the fkin, belong the febaceous glandules, both limpleand compound (§. 202 to 205 ), which are feated in many places under the fkin in the cellular fabric ; from whence perforating the fkin by their excretory du6t, they pour out a foft half fluid liniment, to oil the cuticle, of an harder conflftence in the face, but more oily in the groins and arm-pits, v/ith which the fkin being anointed, flflnes and is defended both from the air and outward attrition ; and from thefe the hairs frequently arife. They are found feated in all parts ot the body, that are under a needhty of being more imme- diately expofed to the air, as in the face, where there are a great number of the compound fort, or wherever the fkin is liable to any great attrition, as in the arm-pits, nipples, groins, glans penis, nympha?, anus, hams, &c. where they moftly fend out hairs. If it be aiked, whether thefe follicles are feated in all parts of the fldn r we anfwer. that although andomy "does not eVery where demonffrate them, yet it feems probable, that they are in no part abfent, as may appear fi'om the fordes or raucous filth coHedled about the whole fur- face of the body, feemingly of the febaceous kind. But there is another fort of liniment or oily ointment poured out upon the ikin from the fat itfelf, by its particular pores, with- out the intervention of glands (§. 202.) ; and this more efpecially, where the ikin is clothed with hair, as in the fcalp. §• 430- Senfe of Touchy &c. 7 §. 430. Again, both the hair and nails are appendages to the fkin. The former are fcattered almoft over the v/hole furface of the body, in moll parts Ihort and foft, but longer upon the head, mouth, cheeks and chin, with the bread in men j alfo upon the fore-part of the limbs, in the arm-pits, groins and pubes. Of thefe, the fhorter grow out of the fkin, but the longer arife with a bulbous root, which is membra- nous, fenlible and vafcular, feated in the cel- lular fubllance beneath the fkin, wherein the medullary and particular coloured bulb or root is contained. The covering of this root or bulb, filled with a pulp, palfes out in a cylindrical figure through a pore, or opening of the fkin to the cuticle, which is extended along with it, fo as to form a capfule to the hair itfelf, which, by this means, is rendered permanent and in- corruptible 3 but beyond the furface of the cu- ticle, the covering of the hair is not demon- flrable, though the fpungy and cdllular matter be continued through the whole length of, the hair. The hairs grow naturally in the cellular fubflance under the fiein, but, by difeafe, they are fometimes formed within the fat of other parts. They grow continually, and are re- newed again, after being cut by a protrufion of their medullary fubllance from the fkin outward, under a produdtion of the cuticle. When the hairs are defiit'ute of this medulla in old people, they dry up, fplit, and fail olf. From the faid medulla, the hairs alfo receive or change their colour. They feem to per- fpire through their extremities, and pofhblv B 4 through- S Senfe of Touch, &c. throughout their whole furface, as we may conclude from the conftant force of protrufion in their medulla, which, in the plica polonica, wants a boundary to terminate it. [To which add, the luminous ftreaks or rays that come out from the hairs of an animal eledlrified. The fubcutanous fat or oil feems to follow and tranfude through the medullary tradt and pores of the hairs.] 431. The nails are of the nature and fa- bric of the cuticle, like which they are alfo infenhble and renewable, after being cut or fallen off. They are found placed upon the backs of the ends of the fingers and toes, which they fupport to make a due refiftance in the apprehenfion of objedts, having the ner- vous papillary bodies, that ferve the organ of touch, placed under their lower furface. They arife with a fquare root, intermixed with the periofieum, a little before the lafi; joints, from betwixt the outer and inner firatum of the fkin, and pafling on foft, go out by a lunar cleft in the external plate of the jlcin, where the cuticle returns back, and enters into a clofe adhefion with the root of the nail, together with which it is extended forward as an outer covering. [The nail itfelf is of a foft tender fabric where it firfi: arifes, partly covered by the fkin ; but, by age and contadl with the air, it, in time, hardens into a folid, horny, and elafiic body, compofed of long hair-like threads, cemented together by interpofed glue, and di- fiinguifliable from each other by intervening .C^ki or furrows, by which one may be able to fplit Senfe of Touch, &c. 9 fplit them into a number of lefler orders. The nail thus formed extends itfelf to the ex- tremity of the finger, and is in this tradt lined all along internally within its concave furface, by an expanfion of the true Ikin, and fubjacent pe- riofteum intermixed, the filaments of which arife firfl: fiiort, and are afterwards continued of a greater length, ’till they become longefi: of all at the extremity of the nail to which they cohere. Thefe are mofi; intimately con- nefted into the root of the nail. Over or upon the outer furface of the nail, home part of the Ikin is again folded, but at liberty and diftindt about it. The tendons, however, do not reach quite fo far as the nail.] §. 432. The cellular fubftance is without fat only in a few places, to allow a necefiary motion to the Ikin. Where it is replenllhed with it, ferves to defend the warmth of inter- nal parts from the cold air, to render the ikin moveable upon the mufcles, to fill up the ca- vities betwixt the mufcles themfelves, and to render the whole body white and uniform. The fidn, cuticle, and its Malpighian mucus, ferve not only to limit the external bounds of the body every where, but likewife v/here they feem to be perforated, paifing inward they desenerate bv degrees. For the cuticle is ma- nifeftly extended into the anus, urethra, va- gina, cornea of the eye, auditory pafiage, mouth and tongue, nor is it wanting even iri the ftomach itfelf and inteftines, although, by the perpetual warmth and'moifture, its fabric be altered, and extended or relaxed into their villous 10 Senfe of Touch, &c.' villous covering. Thus the true fkin is con- tinued into the internal fabric of the palate, tongue, .pharynx, noftrils, vagina, &c. where it degenerates always into a white, thick, pul- py, commonly called nervous coat of thofe parts. §.433. What has been hitherto advanced, is fufficient to enable us to underhand the na- ture of touch. The papilla, feated in the larger winding ridges at the ends of the fingers, regularly difpofed in fpiral folds, are, by the attention of the mind, a little raifed or ereded, as appears from frights or fliiverings, as we fee in the nipples of women, in the handling of tangible objeds, and by light fridion, where- by, receiving the impreflicn of the objed into their nervous fabric, it is thence conveyed, by the trunks of the nerves, to the brain. This is what we call the touch, wherebv we become fenfible chiefly of the roughnefs of objedts, in which fome perlons have fo fharp a ienfation, that they have been known to dillinguifli co- lours, by touching the furface only. Ey this fenfation we perceive heat, when it exceeds in bodies the heat of our fingers; and weight likewife, when it preffes mere than is ufual. Humidity we judge of by the prefence of wa- ter, 'and a foftnefs or y eliding of the objed ; hardnefs from a yeilding of the finger ; figure from the limits or rough circuraferibed furface j diflance from a rude calculation or dtimate made by experience, to which the length of the arm ferves as a meafure ; fo the touch lerves to corred the miflakes of our other fenfes. §■ 434 - n Senfe of T^ouchy &c. §. 434. The mucous body of Malplghius moderates the adtion of the tadlile objedt, and preferves the foftnefs and found ftate of the pa- pillae. The cuticle excludes the air from wi- thering and deftroyihg the fKin, qualifies the impreffions of bodies, fo that they may be only fufficient to affedt the touch, without caufing pain; and therefore, when it is become too thick by ufe, the fenfe of feeling is either loft or leffened ; but if it be too thin and foft, the touch becomes painful. The hairs ferve to de- fend the cuticle from abrafion, to preferve and increafe the heat, to cover and conceal fome parts, and render the membranes of others ir- ritable, which nature reouired to be o-uarded from the entrance of infedis; and perhaps they may ferve to exhale fome ufelefs vapours. The nails ferve to guard the touch, that the papillae and ends of the fingers may not be bent back by the refiftance of tangible objedls : at the fame time they increafe the power of apprehen- fion, and affift in the handling minute objedls. In brute animals they generally ferve as wea- pons of offence, and might be of the fame ufe to man, if they w’ere not cut off. §. 435. But thefe are not all the ufes of the fidn, for one moft important office of that in- ftrument, is to perfpire or exhale from the bo- dy a large quantity of humours and other mat- ters, to be carried off by the air. Accordingly, the whole furface of the Ikin fweats out a va- pour, by an infinite number of fmall arteries, either coiled up into papillae, or fpread on the fkin itfelf, v/hich pafs oat, and exhale through cor- 12 Senfe of T’ouch^ &c. correfponding pores of the cuticle; although the courfe or diredtion of the veffels which pour out this vapour be changed in paffing from the fkin to the cuticle. Thefe exhaling veflels or arteries, are eafily demonflrated, by an injedtion of water or filh glue into the arteries ; for then they fweat out from all parts of the fldn an in- finite number of fmall drops, which being transfufed under the cuticle, rendered impervi- ous by death, raife it up into a blifler. §. 436. In a living perfon this exhalation is many ways demonftrable. A clean looking- glafs, placed againft the warm and naked fkin, is quickly obfcured by the moift vapour. In fubterraneous caverns, where the air is more dcnfe, it more plainly goes off into the air, from the whole furface of the body, in the form of a vifible and thick cloud. §. 437. Whenever the motion of the blood is increased, while at the fame time the fkin is hot and relaxed, the fmall cutaneous pores, in- flead of an invifible vapour, difcharge fweat ^ confining of minute, but vifible drops, which run together into larger drops, by joining with others of the fame kind. But thofe parts chiefly are fubjedt to fweat which are hotted: ; that is to fay, where the fubcutaneous arteries are largeft, and have a greater adlion from their reflflance, as in the head, bread:, and fold- ings of the fkin. The experiment before men- tioned (§. 435.) together with the fimplicity of nature herfelf, joining with the vifible thicknefs or cloiidinefs of the cutaneous, and pulmonary exhalation (§. 436.) fufliciently perfuades us. Se 7 ife of ‘Touchy &c. 13 that the perfpirable matter and fweat, are dlf- charged through one and the fame kind of vef- felsj and differ only by the quantity and celerity of the matter ; but together with the fweat is intermixt the febaceous humour of the glands (§. 427.) and the fubcutaneous oil, which be- ing more plentifully fecreted, and diluted with the arterial juice, flows out of an oily and yel- low confiftence 3 and chiefly gives that fmell and colour to the fweat for which it is re- markable. Hence we find it more foetid in the armpits, groins, and other parts, where thofe glandules are moft numerous or abundant. §. 438. Concerning the nature of perfpira- tioriy we are to enquire by experiments, and by analogy, with the pulmonary exhalation, which more frequently and abundantly perfpires a va- porous cloud of the fame kind, more efpeclally vlfible in a cold air. That what flies off from the body in this exhalation is chiefly water, ap- pears from experiments, by which the breath being condenfed in large veffels, forms or ga- thers into watery drops. Agreeable with this, we find the obfcuring vapour condenfed by a looking-glafs, to be extremely fubtle, fo as wholly to fly off again from It ; and the fame is confirmed by the obfi:ru6ted matter of per- fpiration paffmg off by urine, or frequentlv changing into a diarrhoea j and from the eafy paffage of warm liquors in the form of perfpi- ration, by a hot air ; or elfe by the urinary paf- fages in a cold air. The water of thefe vapours is chiefly from what we drink, but is in part fupplied 14 Senfe of Touchy See. fupplied from the inhalation of the fkin. Fre- quently, even the particular fmell of the ali- ments may be plainly perceived in the perfpi- ration. §. 439. But that there are befides water fome volatile particles intermixt, of an alcaline na- ture, is evident, as well from the nature of our blood, with the Ikilful diftindion which dogs make of their mafters by the feent, and the coniiderable mifehiefs which evidently follow in acute difeafes from a retained perfpiration ; how frequently does it turn inwards, fo as to caufe a palenefs of the urine, or elfe corrupt the air externally, and fpoil it for refpiration ? This volatile alcaline matter arifes from the 4 iner par- ticles of the blood, attenuated by perpetual heat and triture, and changed into an acrimonious nature. Thcfe afford the feent, which is clofe- ly followed by dogs ; and thefe form the elec-= trie atmofphere, which is frequently feen lumi- nous about men and other animals. §. 440. The quantity of our perfpiring moif- ture, is very large, whether we confider the extent of the organ, by which it is feparated, the abundance of vapours derived from the . lungs only ; or barely take a review of the ex- periments made by Sandorius, in which five [others fay three and four] pounds out of eight of the food and drink taken into the body in a natural day, were found to fly off by perlpira- tioii only, exclufive of any of the vilible dif- charges, and without making any addition to the weight of the body. But the cutaneous exha- Senfe of I’ouch, &c. i ^ exhalation is even much larger than this ; fince it not only throws off fuch a quantity of the ingefted food and drink, but likewife what is added to the blood by the way of inhalation (§. 444.) which entering often in a very confi- derable quantity, is thus again expelled. But different difpofitions of the air, and of the hu- man body, caufe great variations in thofe mat- ters. In warm countries, in the fummer months, and in young exercifed perfons, more goes off by tranfpiration from the body, and Icfs by the urine. But in cold climates, during the temperate or winter feafons, in aged or in- aflive perfons, more goes off by the urine than by the infenfible difcharge, v/hich is likewife the cafe in temperate climates, and feafons ; but even there, with animal food, and fermented drinks, the perfpiration exceeds the urine. The difference of time after feeding does alfo in fome meafure vary the quantiiy tranfpired ; but in general it is molt copious at that time when the greater part of the digeiled nourifhment is conveyed into the blood, and therewith atte- nuated fo as to be fit for exhalation. It is na- turally diminifhed in deep, even in the warmer climates, unlefs It be increafed by the heat of bed cloths. §. 441. In general, a plentiful and uniform perfpiration, with drength of body, are good figns of health 5 for whenever it abounds from too great weaknefs, it is obferved to do more mifehief than none at all. It is thus a fign of health, becaufe it denotes a free pervious difpo- fition i6 ^enfe of ’Touchy &c. fition of the veflels, difperfed throughout the whole body, together with a complete di- geftion of the nourilhment, the greater part of which is perfectly attenuated into a volatile or vapory difpofition; When it is diminifhed, it indicates either a conftridion of the fkin, a weakTefs of the heart, or an imperfedt digehi- on of the aliments. Pe|-haps in too great a perfpiration the nervous fpirits themfelves are evaporated. This difcharge is, by moderate ex- ercife, increafed to fix times that of an idle per- fon, even to an half or whole pound in an hour, aided by ftrong and open vefibls, by warm, watery and vinous drinks, with animal food of an eafy digeftion, and a heavy, temperate or moderately warm air, affifted with joyful affedli- ons of the mind. The contrary of thefe either lefifen or fupprefs the perfpiration. However, the continuance of life does not depend on a fcrupulous exadlnefs in the quantity of this dif- charge, which is fo eafily increafed or diminifli- ed by flight caufes; which is fhut up by paints, in many Indian nations, and is inconfiderable in many animals, without any fenfible injury. §. 442. The fweat is evidently of a faline nature, as appears both from the tafle, and from the minute chryftals which appear to (hoot upon the cloaths of fuch as work in glafs- houfes^ as well as by diftillation, which fliows the fweat to be of an alcaline nature. Hence it is, that by this difcharge, the moft malignant matter of many difeafes is thrown off from the body. But in reality, fweat is always a preter- natural Senfe of Touchy 5 cc. 1 7 natural or morbid difcharge, from which a per- fon ought always to be free, unlefs by violent exercife, or other accidents, his conftitution is for a fliort time thrown into a difeafed ftate. Nor is it unfrequent for fweats to do confider- able mifchief in acute difeafes, by wafting the watery parts, and thickening the reft of the blood, at the fame time that it renders the falts more acrimonious. By a too violent motion of the blood, the fweat is rendered extremely fetid; and is fometimes even red, or mixt with blood itfeii ; being eledlrized, it fometimes is lucid. §. 44. V The ufes of perfpiration are to free the blood from its redundant water, and throw out thofe particles, which by repeated circulati- ons have become alcaline, or otherwife acrimo- nious, and poftlbly to exhale therewith an ex- tremely volatile oil, prepared from the fame blood. The fame perfpiration likewife quali- fies and foftens the cuticle, which is a neceftary medium, extended before the tender fenfible papillas. §. 444. But the fame fkin that m.akes this exhalation into the air, is likewife full of fmall veftels,’. which inhale or abforb thin vapours from fhe air, either perpetually, or at leaft when it is not very cold; more efpecially when, the air is damp, the body unexercifed, the mind opprefted with grief, or both under con- ditions contrary to thofe which increafe perfpi- ration before mentioned (§. 430.). Thefe veins are demonftrated by anatomical injedlions, which if thin or watery, fw^eat through them in VoL. II. C . the 1 8 Senfe of Touch, See. the fame manner as through the arteries (§• 43 5O ; moreover, the manifeft operation of medicines in the blood, which were exhaled into the air, or applied to the fkin, prove the fame; fuch as the vapours of mercury, turpentine, faffron, Bath-waters, mercurial plafters, tobac- co, callaquintida, opium, contharides, arfenic, with the fatal effeds of contagious or other poi- fons entering through the fkin ; as in the vene- real infection; to which add the living of ani- mals, almofc without drink in hot iflands, which abound with moifl vapours, from which, how- ever, they fweat and pifs plentifully enough. Laftly, fome extraordinary morbid cafes have demonftra'-ed this, in which a much greater quantity of urine has been difeharged than the quantity of drink taken in. The proportion of this inhalation, is difficult to affign ; but that it is very great in plants, more efpecially in the night time, appears evidently from certain ex- periments, which may be feen in the vegetable flatics of Dr Hales. §. 445. Thefe cutaneous veffels both ex- haling and inhaling, are capable of contradion and relaxation by the power of the nerves. The truth of this appears from the effeds of paffions of the mind, which if joyful, increafe the cir- culation, and relax the exhaling veffiels, fo as to yield eafier to the impulfe of the blood ; from whence, with a ffiortening of the nerves, there follows a rednefs, moifture and turgekence of the fkin. Thofe paffions, on the contrary, which are forrowful, and retard the circulati- on, ^enfe oj Touch, See. 19 on, contradl the exhaling veffels, as appears from the drineft and corrugation of the fkiiij like a goofe-Jkin after frights; and from a diarrhaca caufed by fear. But the fame affedtions feem to open and increafe the power of the inhaling vefl^ls, whence the variolous or peftilential con- tagions are eafily contradled by fear. C 2 LEG- 20 LECTURE XV. Of the Tcife, §. 446. I ■'"'ROM the fenfe of touch, and Its organ, there is but a fmali differ- ence or tranfition to that of the tafe ; which appears by certain experiments to be feated in the tongue chiefly •, for even the mofl; re- lifliing bodies applied to any other part of the mouth are hardly more than felt, exciting fcarce the leafl: fenle of tafle in the mind, if they are not uncommonly acrid and penetrating : and even that fenfe which is fometimes occafloned in the ftomach, cefephagus and fauces, from a rifins: of the aliments, feems alfo to be owinar to the tongue, to which the taftable vapours are conveyed. §. 447, Only the upper and lateral edges of the tongue are fitted to exercife the fenfe of tafte. But by the tongue we underftand a mufcular body, broad and falcated in man, and lodged in the mouth, whofe poflerior and lower parts are varioufly connedled to the adjacent bones and cartilages, while it remains moveable in its anterior and upper part. In thofe porti- ons of the tongue, which make the organ of tafte, the fldn grows to the adjacent mufcu- lar fibres, being continued from the fkin of the face and mouth, only here it is always foft and pulg-like, ft'orn the-,perpetual warmth and moifture. From this min of the tongue arife innu- 21 Of the T^afe. innumerable papillce, of a more confiderabic bulk here than in other parts. Of thefe there are feveral kinds : the firft of them are difpofed in a rank on the back part of the tongue, on each fide the foramen caecum. Thefe, furround- ing that opening like a circle, are for the mofl part conical, having a deep finus in their middle, but are otherwife hard, and but indifferently difpofed for tailing. There are fome other pa- pillae of the fame kind found fcattered before thefe upon the back of the tongue. §. 448. The other kind of papillae are like mufhrooms, lefs and flenderer than the former, of a very cylindric, and fomewhat oval figure, placed at fome fmall difiances from each other, upon the upper furface of the tongue, where they grow fharper pointed, as they lie more forwards, and are moft numerous on the fides of the tongue. The third fort of papills, which abound mofiin number, are fpread largely over the tongue, betwixt the former, with their api- ces fomewhat inclined and fiudluating before, towards the tip of the tongue ; and thefe w'hich are likewife moft numerous in the fides of the tongue, are highly fenfible, and make the true organ of tafte : as for the intermediate, arterial and venal pile, or villi, which ferve for ex- haling and inhaling thin juices, they have no- thing in common with the tafte itfelf, unlefs that by feparating and pouring out a thin juice from the blood upon the back of the tongue, they conduce to foften the papillae, and difiblve the faline or fapid particles. [In the upper and back part of the tongue, are feated many round C 3 fimple 22 Of the Tajie. fimple muciferous glandules, furnifhed each with one or more out-lets, compleated either by an hemifpherical membrane, or by the flefh of the tongue. Some of thefe open into an ob- fcure foramen, or rather antrum crecum^ of an uncertain figure, and feated in the midft of the largeft nipples of the tongue, §. 44.8.] §. 449. Thefe papills have doubtlefs fmall nerves detached into them, befides numerous vefTels, although they are difficult to trace ; for we obferve, that larger nerves go to the tongue, than almofl in any inftance which we have in other parts : for befides the nerve of the eighth pair, which being one of the principal of the three branches, enters the bads of the tongue, deeply covered by the cerato-gloffus, near the os hyoidcs ; there is alfo a confiderable nerve that goes to the tongue, and its mufcles, from the ninth pair, which having inofculated with the firft nerve of the neck, and with the large cervical gaglion, it fends a branch down- ward, and frequently joins the eighth pair; but conflantly communicates with the fecond and third of the neck, from whence its branches afcend to the mufcles arifing from the fternum; and frequently communicate with the phrenic nerve j after which the reft of its trunk goes to the tongue. This communicates, by many branches, with the fiftii pair in the cerato-glof- fus, and is more efpecially fpent in the genic- gloffus. Laftly, the third branch of tlie fifth pair havir>g fent up or received the cord of the ■■n|aanum, and given other branches to the iiiic.rnal pteryogoides, with the maxillary and fublin- Of the Tafle. 23 fublinqual glands, pafles with its principal trunk behind the cerato-gloffus, where it joins the ninth pair, and enters the tongue, deeply in company with the artery ; together with which it is extended to the tip of the tongue, w h re it becomes cutaneous. To this nerve, the e- fore, if there be any prerogative or preference, the fenfe of tafte is to be more efpecially af- cribed. [Laftly, the nipples or papillse of the tongue are of a hard texture, each papilla hav- ing its pulpy fabrick made up by a number of fmall nerves, arteries and veins, conjoined or wound up together into a button or protube- rance, by a firm cellular fubftance.] §. 450. Over the papillae of the human tongue is fpread only a fingle mucous and fe- mipellucid covering, which flridly adheres to them, and ferves them as a cuticle. But in brute animals, a perforated raucous network re- ceives the papilla, which are in a manner wrapped up in cafes or capfules of this mucous body, covered with the cuticle. §. 451. Under thofe papillae are fpread the mufcles which make the flefhy body of the tongue ; which are very numerous, and hardly extricable in the human tongue : in the low^er part, it is in a great part made up of the genio- glolTus raufcle, extended outwards, from the meeting of the chin, and diftributed like rays into the fubftance of the tongue. The upper and lateral parts are compofed by the ftyloglof- fus, whofe fibres run to the tip of the tongue ; which in its middle part, betwixt the former mufcles, is compofed of one proper to itfelf, C 4 called 24 Of called llngualU^ which arihng from before the pharynx and origin of the ftylo-glolTus, only lower, goes out forward, and terminating be- twixt the faid geniogloffus and ftylog ofius, makes up a very conhderable part of the tongue. The back pait of the tongue is made up of the fibres of the ceratogloifus, which afcend up- ward and backward ; and by the fibres of the cerato-gloffus, a mufcle diftindt from the for- mer, which arifes from the fmall bones, and next ad;acent bafis of the os hyoides ; from whence pafling outward, with Its lateral porti- ons, covered by the genioglofius, it joins the ftylogloffus, and difappears in the tongue. By the action of thefe mufcles, the whole tongue is moveable in all diredlions, and capable of figuring its own fubftance, fo as to form a hol- low, by the elevation of the ftyloglofii, which it again flattens by the ceratoglofii, but con- trails itfelf into a narrow and almoli cylindrical figure, by the tranfverfe fibres from one fide to the other, together with which there are many other orders of fibres, intermixt with a thick fat ; fo that they cannot be traced in the human tongue. §. 452. The arteries of the tongue are nu- merous : one that is larger and deeper afeends in a ferpentine courfe from the outer carotid, and extends to the tip of the tongue ; and a lelfer fuperficial artery, incumbent on the fub- lingual gland, either arifes from, or inofculates with the preceding ; or elfe there are various fmall branches derived from the pofterior labi- als I and from the branches proper to tire lips, or of the I’afe. 2^ orthofe of the tonfils. The veins of the tongue are variouily wove, and difficult to defcribej fome of which lying deep, accompany the nerve of the ninth pair ; and others that are fuperficial accompany the mental artery, and inofculating with the former, fends out the ranular vein ; but all of them meet together in a large vein, which is one branch of the internal jugular coming from the brain. Thefe veins varioufly communicate with the adjacent complications or net-works belonging to the tonfils, pharynx, thyroid-gland and fkin ; and in the back of the tongue, before the epiglottis, there is a commu- nication betwixt the right and left lide of the venal plexus. §. 453. The papule? of the tongue, which are larger and fofter than tho'e of the fkin, per- petually moift, perform the office of touch more exquifitely than thofe of the fmall and dry cutaneous papilla j and from hence the tongue is liable to a ffiarper degree of pain : moreover, naked falts are not otherwife per- ceived than under a fenfe of moifture or of pain. But the papills of the tongue being raifed a little protuberant, to perform the office of tafle, from falts diffolved in, water, or faliva, and ap- plied againft their tips or fummits, are affedted in a particular manner ; which being diflin- guiffied by the mind, and referred to certain daffies, are called favour? or tajies^ either four, fweet, rough, bitter, faline, urinous, fpirituous, aromatic, or pungent and acrid, with others of various kinds, refulting partly from pure falts, and in part from an intermixture of the fubtle animal, 26 Of the Tajie. animal, or vegetable oils, varioufly compound- ed and changing each other : but all cauftic falts, or fuch as are acrid in a high degree, ex- cite pain inftead of tafte. If it be enquired, whether the diverfityof flavours arifes from the different figures which are natural to falts ? and whether this does not appear, from the cubical figure in which fea-falt (hoots, the prifraatical figure of nitre, or the particular configuration of vitriol, fugar, &c ? We anfwer, that this does not feem probable, for even taftelefs chryftals have their particular configurations j and the tafte arifing from very different falts, and dif- ferently qualified objeds of this fenfe, are too much alike each other, and at the fame time too Inconflant or changeable to allow fuch a theory as for example, in nitre. The mecha- nical reafon, therefo e, of the diverfity of fla- vours, feems to refide in the intrinfic fabrick or appofitioii of their elements, which do not fall under the fciutiny of our fenfes, §. 454. But the nature or difpofitlon of the covering with which the papillsB are cloathed, together with that of the juices, and of the ali- ments lodged in the idomach, have a confider- able (liare in determining the fenfe of tafle ; in- fomuch, that the fame flavour does not equally pleafe or affedt the organ In all ages alike, nor in perfons of all temperatures ; nor even in one and the fame perfon at different times, who (liall be differently accuflomed in health or va- rioufly difeafed. In general, whatever contains lefs fait than the faliva itfelf, feems inlipid. §• 45 S' Of the Tiijle. 27 §. 455. The fpiritaous parts, more efpeci- ally of vegetables, either penetrate into the pa- pillae themfelves, or elfe are abforbed by the ad- jacent pile or villi of the tongue, as may ap- pear from the fpeedy recmital of the drength by vinous or aromatic liquors of this kind, even before they are received into the domach. §. 456. Nature defigned the difference of flavours to be felt by the tongue, that we might know and didinguida fuch foods as are mod ia- lutary ; for in general, there is not any one kind of aliment healthy, that is of a difagreeable tade ; nor are there any ill faded that are fit for our nourifhment. For it mmd be obferved, that we here take no notice of excefs, by which the mod healthy food may be prejudicial. In this manner nature has invited us to take neceffary food, as well by pain called hunger, as by the pleafure arifing from the fenfe of tade. But brute animals, who have not like ourfelves the advantage of learning from each other by in- drudtion, have the faculty of didinguifhing fla- vours more accurately, by which they are ad- monifhed to abdain cautioufly from poifonous or unhealthy food j and therefore it is, that her- bivorous cattle, to which a great diverfity of noxious plants are offered amongd their food, are furnifhed with fuch large and long papilla?, of fo elegant a drudure in the tongue, of which we have lefs need. L E C- 28 LECTURE XVI. Of Smelling. §• 457* ^ fame life, likewifc, of dif- ^ tinguirhing prejudicial from fa- iutary food, the fenfe of fmelling conduces, by which we even difcern and are admonifhed to avoid, before it comes either to our touch or tafte, to which it might be otherwife dangerous, when of a malignant nature; although conti- nual pradtice even in this faculty, has alfo ren- dered it more ufeful and accurate among brute animals than in ourfelves. For men who have been brought up wild by themfelves, without debauching the fcent by a variety of fmells, have been obferved not to make any difficult choice in gathering herbage or aliments for their food. Finally, the powers and virtues of medicinal plants, are hardly to be better known than by the fimple teflimony of tailing and fmelling. From hence it is, that in all animals, thefe or- gans are placed together: and from hence the fmellins; is flrong^er, and the organs larger, in thofe animals which are to feek their prey at a confiderable diftance, or to reject malignant plants from among thofe that are fit for food. §. 458. The fenfe of fmelling is performed by means of a foft pulpy membrane, full of pores and fmall vefl'els, which lines the whole internal cavity of the noftrils, being thicker up- on the feptum and principal convolutions, but tiiinner Of Stnelling, 2^ thinner in the finufles. Within this mem- brane, are diftributed abundance of foft nerves throughout the middle of its fabric, from the firft pair, (§. 37 i.)j which defcend through the holes of the os cribrofum into the feptum narium, but, in fuch a manner, that it is very difficult to trace them to their extremities and into the feptum. Other lateral nerves come from the fecond branch of the fifth pair, in company with the blood-veffels, and forae from the infra-orbital-branch in the maxillary finus. Moreover, the fore-part of the feptum ]ias a fmall twig from the ophthalmic of the firil branch belonging to the fifth pair. §. 459. The arteries, which go to the nofe, are marty, feveral from the internal maxillary branches, from the three nafal ones, to wit, the upper and the lateral, from the ophthalmic branch of the internal carotid, from branches of the palatine artery, and from the infra- orbital within the finufles. The veins run to‘- gether in company with arteries, and form a large plexus, by uniting upon the external pte- rygoide mufcle, and communicate with the finufles of the dura mater ; from whence they open together into the outer branch of the in- ternal jugular. The laid arteries fupply the nourifhment, warmth, and mucus, neceflary to thefe parts. § 460. The neceflary reduction of the hu- ma ' head, to that of a round figure, has in us given, to the organ of fmelling, but a fmall extent of furface , but to enlarge this the more, nature has made the internal parts of the nofe 2 ' varioufly 30 Of Smelliiig. varloufly hollow and complicated. Firfl then, by the nares or internal nofe, we underftand the multiform cavity, which begins before from the nodrils, and, extending tranfverfely backward, over the roof of the palate under the os criborfum, terminates at the cavity of the fauces. This cavity is divided into two, by a fepium or partition of bone, which de- fcends above from the plate of the cribrofum, but below is formed by the vomer, and in its fore-part is compleated by a triangular carti- lage, -whofe furface is largely extended and very fenfible. §. 461. Moreover, the lateral furfaces of the nares are increafed by the fpiral volution of the ojfa turbinata j the uppermoft of which are fmall turns or folds of a fpiral figure, from the upper part of the os cribrofum. The middle fold belongs to the fame, fomewhat ob- long like a couch or fliell, internally convex, externally concave, riling into an edge on each fide, and all over rough with little finuofities or excavations, and inwardly filled with fpungy ceils or recedes ; the whole being fufpended in a tranfverfe pofition, and fupported or proped by particular eminences in the bones of the pa- late and upper jaw. The lowermoft turbina, fomewhat like the middle ones, do like them refemble the figure of a mufcle- fliell, but longer j for the moft part diftindt or divided from the former, but fometimes conjoined by a bony plate, which is moft frequently of a membranous nature. This bony appendix, being Of Smelling. 3 1 being extended upwards in a fquare form, ferves to complete the maxillary finus. §. 462. From hence the cavity of the nares is enlarged or dilated by various finuffes, which are a fort of receflcs or appendages to the whole. And firft, the frontal or uppermoft finufles, which are not always prefent, are of an irre- gular figure, intercepted betwixt the anterior and pofterior plate of the frontal bone, where it forms the fuperciliary protuberances; and thefe, being not found in a foetus, feem to arife from the adion of the corrugator and other mufcles, which draw the anterior plate of this bone outward, fo as to increafe the diploe into large cells, in the fdme manner as we obferve in the maftoide procefs, from the like caufe. Thefe open in the upper part of the nares, into the anterior cell of the os pa- pyraceum. §.463. In the fecond place come the vioideal f nujj'es^ which are four or more, on each fide, in the outer part of the os cribrofum, like the ceils of an honey-comb, compleated above by the cellular or fpungy middle part of the os frontis, and before by the os unguis ; from whence they open by many fmall tubes, in a tranfverfe pofition, into the upper part of the nares. With thefe are continuous the cells in the pavement or bottom of the orbits and thofe, engraved in the os planum and maxillare, are continued from them outward. In a third place, this finus is contiguous on each fide with the cavity or (inm of the tnukiform bone, ex- tending largely on each fide towards the os • , cribrofum 32 Of Smelling. cribrofum and palatinum, which is itfelf form- ed, in a dry preparation, by a cartilage of large extent in the foetus, and by a folid bone, which gradually widens under the integuments, with an ample cell, either fingle or divided, and opening forv^^ard, by its aperture or foramen, into the fuperior part of the meatus narium. §. 464. The laft, lovvermoft, and biggeft finus, which, in a foetus, is inconfiderable, but, in an adult, very large, is that formed in the bone of the upper janv by feveral thin bony plates. The opening of this into the nofe, is betwixt the os unguis, bone of the palate, and the proper lamella or plate, which accedes to it from the bottom of the os turbinatum. Which opening is fo much leiTened by the furrounding membranes, as to form only a moderate round aperture in the fpace betwixt the middle and bottom of the os fpongiofum. §.465. The nerves of the nofe, being al- rnoil naked, required a defence from the air, which is continually drawn through the noftrils by the ufe of refpiration ; nature has, there- fore, fupplied this part, which is the organ of fmeiling, with a thick infipid mucus, very fluid in its flrft feparation, and not at all faline, but, by the air, condenfes into a thick dry crufl:, more conflflent here than in other parts of the ■body. By this mucus, the nerves are defended from drying, and guarded from pain. It is poured out from many fmall arteries of the noftrils, and depofited partly into numerous cylindrical duds, and partly into round vifible cripts or cells 3 from whence it flov\'s out all ' . ove4 Of Smelling. 33 over the farface of the olfadory membrane, which is therewith anointed on all fides. In the feptum, runs down forward a long fmus to a conliderable length, which is common to many muciferous pores : this mucus is accu- mulated in the night time, but in the day ex- pelled by blowing the nofe, or fometimes more powerfully by fneezing ; and may offend by its excefs or tenuity, or irritate, by too great thicknefs, the very fenfible nerves ; from whence a fneezing is excited for its removal. But the finuffes of this part, which abound with mucus, are this way varioufly evacuated, agreeable to the different poftures of the body, by which always fome of them are at liberty to free themfelves, whether the head be ered, or inclined forward or laterally ; yet fo, that gene- rally the maxillary and fphenoidal finuffes are more difficultly emptied than the reft. More- over, the tears defcend, by a channel proper to themfelves, into the cavity of the nofe, by which they moiften and dilute the mucus, §. 466. To the extreme parts of the nares or organs of fmelling, is prefixed the nofe, lined inwardly with a membrane of the fame nature, compofed of two bones and ufually fix cartilages, two of which are continued toge- .ther into the middle feptum (§. 240,). Thefe cartilages render the nofe moveable by its pro- per mufcles, fo as to be ralfed and dilated by a mufcle common to the upper lip, and to be contraded together into a narrower compafs, by the proper depreffor and compreffor mufcle pulling down the feptum. Thus it form's; an ' Vci,. II. 1 ) , -aerial 34 Of Smelling. air-engine, which, for the reception of fmells, can take air in a larger quantity by dilating, then contrading again by elafticity, when the air is afterwards abundantly thrown out. §. 467. The air, therefore, filled with the fubtle and invifible effluvia of bodies, confifi;- ing of their volatile, oily, and faline particles, is, by the powers of refpiration (§. 282.), urged through the nofe, fo as to apply the faid particles to the almoft naked, and conftantly foft olfadory nerves, in which a kind of feel- ing is excited, which we call fmelling ; and by this fenfe, we diftinguiffl the feveral kinds of oils, falts, and other matters, difficultly re- ducible to clafihs, which hereby we perceive in- diftindlly j whence they are difficultly recalled to memory, though the odours, already eftab- liffied, are fufficient enough for our purpofes. This fenfe ferves to admonifli us of any per- nicious putrefadlion, of any violent acrimony, or of a mild, foapy, and ufeful difpofition in bodies. And as fait, joined with an oil, is the objedl of tafte, fo a volatile oil, aided with falts, ferves to excite fmells ; whence the affi- nity of the two fenfes, which conjundtly affilf and move each other, may be ealily underftood. But the particles, which excite fmell, are more volatile, as thofe, belonging to the tafte, are ‘ more fixed, whence the ditference in thefe or- gans may poffibly confifi: in the thick mucous V cuticle, w'hich, being fpread over the tongue, intercepts the adion of the more fubtle faliny effluvaa from aembrane of the tympanum is difpofed for the hearing of weak founds ; as the other mufcle ferves to moderate in too violent founds, by drawing the malleus from the incus j by which, therefore, the propagation of the fonorous tremors is inter- rupted. If the membrane of the tympanum be broke, or the bones of hearing diflocated, the perfon becomes, at firft, hard of hearing, and afterwards perfedlly deaf. [This part is the feat of that flight hearing, which is pro- pagated through theTones of the Ikulh] §. 483. The malleus returns the tremors impreffed upon the membrane of the tympa- num, to the incus, which is a fhort thick little bone, Of Hearing. 47 bone, articulated with the former behind, by a broad furface, with two fulci and a middle emi- nence. The fhorter leg of this bone, whofe little body is bifurcated, being fufpended by a ligament, is held firm into a fulcus proper to the bone. It defccnds a confiderable length parallel to the malleus, and by a fomewhat crooked extremity, is adapted to the fourth or- bicular bone, which it receives, convex on one fide, flatter on the other, and refting upon the flapes, to which its protuberances are imparted. §. 484. The flapes, aptly enough fo called, from its figure, lies inclined, but more back- ward than forward, with a hollow head that receives the incus, from whence proceed two little crooked legs ; but below, its oval bafis is occupied by a foramen or aperture of a corref- ponding figure, commonly called the fenefra ovalis. Here the legs, which are fulcated in- wardly, are conjoined by a tenfe membrane af- fixt to the hollow bafis. This bone of the flapes Is covered by its own mufcle, which be- ing included in a bony papilla or cafe, fends out a very fmall tendon, which is inferted under the incus, into the head of the flapes. Hence it feems to draw the flapes, that it may lie higher up, under the back part of the feneflra ovalis, and pafs out of it before. Thus the nervous pulp of the veflibulum, is prefied by the bafis of the flapes, and by the air of the tympanum. The whole courfe or feat of the flapes, is fepa- rated from the refl of the tympanum, by a membrane proper to itfelf. 48 Of Hearing. §, 485. There are various channels whlfch pais out from the cavity of the tympanum. The larger of thefe ‘is that which goes out forward from the anterior fide, betwixt the multiform and temporal bonCj emerges and opens into a correfponding elliptical and diverging cone, part- ly membranous, and in part made up of carti- lages ; it opens by a very ample elliptical aper- ture, turning inward and forward behind the nares, into the cavity of the fauces : this, which is called theEuftachian tube, is lined with a po- rous rhembrane, full of crypts and mucous cells, continued from and like unto the mem- brane of the nares. This is the tube, which by the adtion of the circumjacent mufcles may be comprefTed and clofed, and probably a little relaxed and opened again, by the circumflex mufcle of the moveable palate. By this canal the infpired air enters into the tympanum to be changed or renewed^ and the furrounding mu- cus of the little bones and other parts are this way depofited ; nor is it at all improbable, that the air enters by this tube, to fupport the tympanum, when it is preffed inward by the more violent founds ; for founds themfelves, re- ceived into the mouth, are this way conveyed to the organ of hearing. In infpiration, the air prefl'es the membrane of the tympanum out- ward ; and from thence proceeds that clafliing or whifpering noife, by which the hearing is obfeured, when the mouth is held wide open in yawning ; for then the air entering more abun- dantly through the cavity of the tube, to the tvrapa- Of Hearing, 49 tympanum, refifts the tremors of the external air. §. 486. Two other patTages lead from the tympanum to ih^Jabyrinth^ or innermoft cham- ber of the ear. And again, the feneftra ovalis, not covered by any membrane, leads into the vefibulum^ v^^hich is a round cavity, formed in a very hard part of the os petrofum, that lies near the inner part of the tympanum. In the fame cavity, alfo, open the five apertures be- longing to the three femicircular canals, Thefe are formed of a diftindt hard fhell, very firm and perfedt, even in a fcetus, which being fur- rounded with a fpungy bone, are lodged in a cavity of the os petrofum j which in adults is extremely hard, extended into large femicircles, which have an ample opening betwixt them. The larger pofterior and lower of thefe circles, is perpendicular ; alfo the middle and upper one is placed towards the perpendiclar : but the outermofl and leafl; is horizontal. The inner mouth or aperture of the uppermoft of thefe, meets with the upper opening of the pofterior ring, and both join into one. §. 487. But the cochlea is a part flill more wonderful, feated in an inclined pofture, wdthin the anterior portion of the os petrofum. Into one part of this cavity opens the veftibulum, and into the other the fenejlra relunda of the tympanum, which is concealed behind a pro- tuberance in the bottom of the tympanum. The cochlea itfelf, is made up of a nucleus of boite, of a conical figure, with its apex inclined inward, divided by a middle fulcus, both through VoL. II. E its Of Hearing. its bafis and through its whole length, and per- forated with innumerable fmall foramina into the tubes which are called fcalae. About this nucleus are wrapt two turns and a half of a canal, which even in the fcetus is made up of a diftind; fhell-like fubftance, peculiar to itfelf ; and in the adult is united into one, with the ad- jacent bone: and this winding canal diminiflies gradually in a conical figure, from the two forementioned openings towards the tip of the nucleus, and is bilocular, or made up of two apartments, divided by a partition, called lanella Jpiralis. This, at its larger end, is bony, and extended out of the nucleus, at right angles, into a cavity; is flriated and every way wrapt up by the internal perioflium, as in acapfule. Ano- ther external part hereto belonging, is a mem- brane which likewife divides the canal : thus there are formed two diftindl femicanals, called fcalee ; the interior and pofterior of which be- gins from the feneffra rotunda, where it is fhut by a membrane ; and the other begins before, from the veftibulum. In the tip of the cochlea is formed a third funnel-like cavity, which opens into the fcalas by a fmall tube, and com- municates with them on each fide; but in ma- ny bodies it alio comnrunicates with the cavity of the bucket, that is filled with the nerve. §. 488. The blood-vefi'els of the outer ear come from the proper auricular branches of the temporals ,; _^thoie to the membrane of the tym- panum are either from the temporal, from the ftylomafioideal, or from both; thofe of the - meatus auditoriuo c.^me from the former ; tiiol'e ' • to ty Hearing. to the tympanum, were defcribed (§. 480,) and the veflels belonging to the veftibulum, coch- lea and femicircular canals, are from the verte- brals, and ftylomaftoideals. §. 489. It now remains, that we defcribethe nerves deftined to the fcnfe of hearing, of which the principal is that called the /event h (§. 371.). This nerve enters into the internal auditory finus of the os petrofum, in the blind end of which it divides, fending off the fmaller up- ward, through the opening of a canal in the finus ; whence palling tranfverfely, it is afterwards bent behind the tympanum ; in this part def- cending, it gives off a branch through a pecu- liar channel to the tympanum, which afcends betwixt the malleus and incus, and goes out of the tympanum, through a fillure behind the ar- ticulation of the low^er jaw, afterwards inferting itfelf into the nerve of the tongue (§. 449.) the reafon of which fecret communication is ob- fcure, but ferves to explain the confent of the teeth, fet on an edge by lliarp founds, a removal of their pain by burning the ear, 6cc. The red; of the nerve efcaping by the lides of the ftyloide procefs, is diflributed through the external ear, the parotid gland, a large part of the face, and upper part of the neck, both cutaneous and muf- cular ; and in the face forms numberlefs inof- culations, both betwixt its own branches, as well as with thofe of the firft, fecond, third, and fifth pair ; and it likevv^ife communicates with the eighth pair, and the third cervical pair. But to the immediate organ of hearing it fends either no branches, or at lead: very fmall ones. The E 2 outer ^2 Of Hearing. outer ear again receives other nerves in its fore part, from the third branch of the fifth pair, and in its back part to the fecond and third of the cervicals. §. 490. But the [oft portion of the auditory nerve arifes larger, but more obfcure, from the fourth ventricle of the brain itfelf (§. 371.) and enters by very minute threads through exceed- ing fmall holes of the inner auditory finus, which go in part to the veftibulum, and in part to the cochlea. The branches in the vef- tibulum, form a pulp-like tender membrane, which is every way extended through the femi- circular canals. The other part entering the cochlea, has an obfcure termination. §. 491. With rcfpedt to the nerve, which is diftributed through the veftibulum, and femi- circular canals, there is no doubt but It is ftruck by the tremors of the external air, propagated to the ftapes, from whence the tremors imme- diately pafs through the oval feneftra, to prefs upon the naked pulp of the nerve. That part of the nerve which enters the cochlea, is alto- gether obfcure in its termination, although it be probable, that fmall branches from thence pafs through the little foramina (§. 487.) to the pe- ridiftium of the cochlea, and to the membra- nou$;part of the fpiral partition. Whether or iio the tranfverfe nervous filaments pafs out from the nucleus of the cochlea, all the way fuccef- livgly ftiorter through the fpiral plates? and whether, by this mechanifm, it becomes the or- gan of hearing ? are curious queftions, w'hich we are yet hardly able to refolve from anatomy; though Of Hearing. 53 though this feems repugnant to the courfe which we obferve nature takes in brute animals, in birds, and in fifhes, who all hear very cxquifitely, without any cochlea. However this may be in the human body, it is there probable, that the fpiral plate, fpread full of nerves, is agitated with tremors from the ofcillations of the membrane of the tympanum, by which the air in the ca- vity of the tympanum is agitated, fo as to prefs the membrane of the round feneftra, which again agitates the air contained in the cochlea. §. 492. The preceding conjedure is indeed elegant, fince the fpiral plates make up a tri- angle, ending in a fhort point towards the tip, by which it may be conceived to contain an in- finite number of nervous cords, continually fliortening in their length j and by that means adapted an harmonical unifon or confonance, (§. 484.) according to the variety of acute and grave founds, fo as to tremble together at the fame time with mofl of them ; namely, the longed: cords in the bafis of the cochlea, with grave founds, and the fhorteft cords nearer the tip or apex, with the diarper founds. [¥/he- ther founds are perceived in the middle fetni- circular canals, which yet are faid to be abfent in the elephant ?] §. 493. P'rom what has been faid, it appears, that the elaftic waves or tremors of the aif, ar- rive through the outer ear and auditory paffage, to the membrane of the tympanum ; and from^ thence the tremors are more accurately conveyed , through the fmall bones, in two ways,' to the vedibulum •, but in a more confafed uncertain E 3 manner 54 ' Q/" Branny. manner through the air of the tympanum, to the round feneftra and cochlea. Of more than this we are not certain : but by undoubted ex- periments, tremors, and even elaftic founds com- municate themfelves by the internal euflachian tube, and through all the bones of the fcull, fo as to imprefs their force upon the auditory nerve. The diftindlion of founds, as to acutenefs and gravity, doubtlefs proceeds from the celerity of the tremors excited in the hearing nerve, ac- cording as they fucceed each other more fwiftly or flowly, in a ihort time ; in order to which, it is not necelTary the mind {hould number them j ’tis fufficient that (he perceive their num- bers to be different, and that this difference ex- cites a variation in her thoughts and ideas thence arifing. Whether the harmony or agreeable- nefs of founds arifes from the number of parts founding together in unifon ? and whether the mind, ignorant of herfeif, numbers the de- grees of confonance, fo as to pleafe herfeif in a majority of them ? thefe are queflions denied by the moft expert muficians, who make it ap- pear, that there is an agreeablenefs, and that very confrJerable, in founds, approaching the lead; to a confonance, and which lies in a pro- portion very difficult to determitie. Why founds often become too fharp for the ear ? Our audi- tory nerves feem to be flrained upon the fpiral plates, in fuch degrees as to be in danger of breaking, after the manner drinking glaffics may be broke by lharp founds ; and as the hear- ing is fometimes almofl loft for a while, by the violently Of Hearing. violently fhrlll whiftlings of the inhabitants of the Canary iflands. REMARK. This loud whiftling that benumbs the ear for a time, is performed by fixing the firft joints of the index and middle finger, at about half an inch afunder, upon the lower incifive teeth, which ferve to cut the wind thus blown violently thro’ a fort of tube, of about half an inch cubical ; whofe fides are the two fingers, met by the lips above and be- low. Thus the air, flrongly cut by the lower teeth, whiffles infinitely louder than when cut by the foft lips only ; fo that it may be heard two or three miles : and if this tube be over-blown, it will ftupify any ear, or even occafion a temporary deafnefs to fome ears, that may have the organs in a certain degree of tenfion ; much as looking at the fplendid noon fun, will caufe a fhort blindnefs in weak eyes. E 4 LEC; LECTURE XVIII. Of the Sight, §. 494. S the organ of hearing perceives Jf\^ the tremors of the air, fo the fight perceives thofe of light ; and as the firft conlifted chiefly of bony organs capable of mak- ing a refonance ; here, on the contrary, the greater part of the eye is compofed of pellucid humours, capable of refrading the more fubtle medium of light ; but the complexity of this organ was neceflary for the defence of its ten- der parts, and from the diverfity of the feveral humours, to be contained each in their proper coverings or integuments. §. 495. Outwardly, a defence is afforded to this organ by the eye-brow or fuperciliumy which is a protuberance of the fkin, fuflained by mufcles, at the bottom of the forehead, full of thick hairs, marfhalled in a regular order, and capable of being pulled down by the adlion of the frontal, corrugator, and orbicular muf- cles, fo as to afford a fhade to the eve in too flrong a light. After this office is finifhed, the eye-brow is raifed again, by the infer tion of the frontal mufcle, thin and fleflay, immediately under the continuous fkin, into a tendinous cap faffenened to the flcull, which cap being of a large quadrangular figure, is drawn backward by the occipital mufcle. A depreffion of the eye-brow ferves alfo to exprefs concern of the mind 3 Of the Sight. mind j as an elevation of it denotes the mind to be in a ferene quiet ftate. This guide alfo con- duces to throw off the fweat and retained duft, or the infers v/hich might fall into the eye. §. 496. The eye-lids or palpebrte, are placed ftill nearer guards before the eye. Here the folds of the fKin, which are thinly extended, from that of the face, run out in a confderable length, and are reflected back with the cellular fubftance, interpofed betwixt the outer and in- ner plate, the latter of which becomes then a thin vafcular membrane, and therefore of a red co- lour, extended before the globe of the eye, and fpread in its foremoft part upon the fclerctica, under the denomination of conjundliva tunica. This production of the fkin is every where co- vered by another of the cuticle, even where it is clofely conjoined with the cornea. The up- per eye-^lid is larger and more moveable j the lower is fmaller, and rather obfequious to the motion of the ocher parts, than moved by any particular forces of its own. The nerves which give fenfibility to the eye-lids, are numerous, from the firft branch of the fifth pair, and like- wife from the fecond j and they abound with arteries from the ophthalmics, and from the branches of the tem.porals, internal maxiliaries, infraorbitals, and others of the face. §. 497. That the eye-lids might Ihut toge- ther more exaClly, they have each of them a cartilaginous arch, called tarfus, upon their mar- gins, which meet together, which is fiender, of a lunar figure, extenuated outw'ard, and ferves to hinder the eye-lid from falling into wrinkles. 5^ Of the Sight,- wrinkles, while it is elevated or deprefled. The elevation of the upper eye-lid is performed by a mufcle, called, from its office, and arifingfrom the dura muter, where that departs from the optic nerve and degenerates into the perioflium of the orbit; from thence the elevator mufcle gradually fpreading, is extended by its expanfion to the tarfus. This elevator is confiderably affifted in its adlion, by the frontalis, and by various con- nexions with the orbicularis, drawn up or di- lated by the former. The upper eye-lid is de- prefTed by the orbicularis mufc'e, which is broad and thinly fpread round the orbit, under the ficin of the eye-lids, to each angle of the eye, which ferve as fixed points to this mufcle ; and it adheres to the os frontis, where that bone joins the upper jaw, and then its fibres are in- ferted into the os frontis, and neareft parts of the upper jaw. The fame mufcle ferves to elevate the lower eye-lid, and covers the eye in fuch a manner that no duft or light can enter it in deep. The lov/er eye-lid is deprefied by a double por- tion of fibres, inferted into the upper lip. Fi- nally, that the protuberant margins of the eye- lids might not injurioufly beat again fl; each other, the cilia or rails of hair are placed fpread- ing outwards, in a row, from the edges of the eye-lids, of different lengths, which by croffing each other make a blind or fhade. Thefe are of ufe in more diftinX vifion, by excluding the extraneous or more fcattered rays, when we require a diflinX reprefen tation of any objeX. §. 498. That the eye-lids rubbing againfi; each other, might not grow together, they are fupplied Of the Sight. 59 fuppHed with a row of febaceous gJanduleSy firfi: noticed by Meibomius ; namely, about thirty little gut-like cells, or more in each eye-lid, placed in general, according to the length of the lid, without ever branching, but compofed of pecu- liar blind finufes, which end at laft in one larger ferpentine du6t, opening by a mouth in the margin of the eye-lid itfelf. Thefe difcharge a foft liniment, which mixes and wadies off with the tears. §. 499. But the perpetual attrition of the eye-lids afcending and defcending againfl: the globe of the eye, is prevented by the diftilling humour, called tears^ which preferve alfo the tendernefs of the membranes and of the cornea, and ferve to wafh out any infedls or other Iharp corpufcles. Thefe form a faline pellucid liquor, that may be evaporated, and never ceafes to be poured over the anterior fur face of the eye, but never runs over the cheeks, unlefs colleded to- gether in a larger quantity, from fome caufe. This liquor is exhaled partly from the arteries of the conjunctiva, as we fee from an imitation of nature by injeCling water j and it is in part believed to proceed from a gland feated in a re- cefs of the orbit of the os frontis, fomewhat hard, and of the conglomerate kind, intermixed with fat, and painted with many blood veffels from the apthalmics and internal maxillaries ; and interfperfed with many fmall nerves ariling from a peculiar branch of the firft trunk of the fifth pair. From this lacrymal glandule in horned cattle defcend three, four or more vifible duCtSj which open on the inner fide of the con- junctiva, 6o Of the Sight. jundlva, upon the eye-lid ; but in man we are not fufficiently certain of thcfe duds ; and for my own part, I have never been able to fee any. The feparation of the tears is increafed by the more frequent contradion of the orbi- cular mufcle, either from irritation, or fome forrowful paffion, by which means the tears are urged over the whole furface of the eye, and conjundiva, which they wafh. §. 500. After the tears have performed their office, fome part of them flying off into the air, the reft, that they might not offend by their quantity, are propelled by the orbicular mufcle, towards its origination next the nofe, to a part which is the loweft of the palpebral margins ; which not being furrounded by the tarfus, does therefore not meet exadly together. Here a caruncle full of cebaceous hairy follicles, of an oblong figure, interpofes and feparates the meet- ing of the eye-lids, at the fame time furnilhing a liniment to thofe parts which have none of the Meibomian duds. Before this part is extend- ed a fmall portion, like a little eye-lid, which defcending perpendicularly, joins the true eye- lids : but at the beginning of this fpace, betwixt the eye-lids, in which the tears are colleded, both in the upper and lower margin, a little papilla ftands out, having each of them one opening, furrounded by callous fleffi, which are perpetually open, unlefs when convulfively clofed. This opening, which is called the pun5lum lachrjmale^ drinks up the tears from the fin us, in which they are colleded, and this partly by tabular attradion, and partly by im- Of the Sight. 6 1 pulfe, from the orbicular mufcle. If thefe points or openings are obftrutled, the tears run over and excoriate the cheek, §. 501. From the faid point or opening, pro- ceeds a fmall dudl, both from the upper and the lower eye-lid, much wider than the open- ing itfelf, but thin and included in the fkin that covers the caruncle ; from whence going tranf- verfely, they both join together, and are infert- ed by two mouths near the uppermoft part of the lachrymal Jack : for thus is called a cavity, formed in the os unguis and upper jaw, lined with a membrane, which is at firll: ligamentary, but afterwards red and pulpy, continued from the membrane of the nares, and is fomewhat of an oval figure. From the fame facculus, is continued a duft, which defcends a little back- ward into the nares, opening there by an ob- lique, oblong aperture, at the bottom of the meatus, covered by the lower os fpongeofum. Through this paflage the fuperfiuous tears defcend into the nofe, which they In part moiften (§. 465.). [A mufcle is by fome af- cribed to this fack 3 but it is not yet fufficlently confirmed to enter the lifl; with the others.] §. 502. The globe of the eye^ properly fo called, comprefied before, but longer than it is broad, is feated in the cavity of a bony orbit, which is almofl of a conical figure, made up by feven bones, which are in the back part, and on the inner-fide perforated, or interrupted by large fifiTures, from whence the bones widend- ing forward, defend the cavity on all fides. But as this is larger than the eye itfelfj the excefs is 6 2 Of the Sight. is on ail fides occupied by a very foft fat, fur- rounding the globe of the eye, that It may both fill and have a free motion within the orbit. §. 503. The eye begins from a confiderable nerve, by the expanfion of whofe coats or tu- nics, thofe of the eye itfelf are compofed. The origin of this optical nerve we have already deferibed (§. 371.); hs progrefs is acrofs under the crus or footftalk of the brain, where it joins with its fellow nerve from the other lidc, and coheres therev/ith for a confiderable length, by a large portion of m.edullary fub- flancc, but yet without intermixing ; fo that the right nerve only bends tlms to the right eye, and the left to the left eye, as we are alTured from experiments. The nerve, therefore, thus enters the orbit a little infledted, of a figure fomewhat round, but deprefied ; and is inferred into the globe of the eye, not in the middle, but a little nearer to the nofe. §. 504. The nerve having reached the eye, depofitsthe inner plate of its dura mater, which it received in the opening of the fphsenoidal bonej and this being expanded and rende.'-ei thicker, makes up the firft coat of the eye, called fclerotica. The other outer plate of the dura mater, receding from the former, makes up the perioftium of the orbit ; but tlie pla ma- ter, which is in this nerve very diftindt and full of vefiels, expands Itfelf as before, fo as to form a thin dark coloured lining to the fclerctica. The remaining inner medullary part of the nerve, continued from the brain, but divided into fila- ments by the cellular fubflance, appears at firit contraCLcd Of the Sight; 63 contra (fled into a depreffed white conical pa- pilla, after which it is again expanded upon the inner membrane of th» eye, fo as to form the retina, §. 505. The fclerctica is in general white, tough, and furnilhed with few velTels, refemb- ling the nature of the cutis or Ikin, of a figure completely enough globular, but comprefifed or flattened before, and of a greater thicknefs back- ward ; to the fore-part of this globe, cut off cir- cularly, is prefixt obliquely, a portion of a more convex or lefs fphere, pellucid and made up of many fcales or plates, replenifhed with a clear water and pellucid vefl'els, very diflicult to de- monftrate j this part, which is extremely fen- fible, and almofl; circular, yet broader at the nofe than towards the temples, is termed the cornea, through which the light paffes into the eye. This greedily imbibes water, and fweats it out again. Before the anterior and flatter part of the fclerotica, and alfo before the cornea, the conjunctiva is detached from each of the eye- lids, and clofely conjoined bv a proper cellular fubflance, that may be inflated (§. 496.), which is replenilhed with veffels, partly red, and partly pellucid continuations of red ones. §. 506. The origination of the chcroides^ is a white circle, terminating the fubflance of the optic nerve, in that part where the retina and the central artery are expanded from it, and periorate it by many fmall foramina. From hence it Jpreads witiiin the fclerotica, concen- trically adhering thereto by a cellular fubflarice and many vcflels, which enter from, the cho- roiues Sa Of the Sight. roides into the fclerotica. This membrane Is outwardly of a brown colour, but inwardly of a more rufiet brown, or almoft black, both which colour and furface are feparable by mace- ration, the innermofl being dillinguifhable by the name of tunica Ruyfchiana. When this has extended itfelf as far as the beginning of the pellucid cornea, it there joins itfelf more accu- rately to the fclerotica, by a cellular fubftance, from whence going off almoff circularly in a different courfe, it forms a kind of rim, called C7"biculus ciliaris : namely, the coat, which was before fpherically expanded, now fubtends cir- cularly from the arch of the cornea, a little con- vex outwardly, and with a deficiency in its middle ; from whence a circular parallel por- tion is taken out, fo as to form a foramen or hole, called the pitpi!^ which is feated nearer towards the nofe, and is larger toward the temple. The anterior part of this round rim, is called the //zh, and the back part feparable from the former, by maceration, is from the colour wdth which it is painted, called uvea. Upon both fides appear numerous ftripes, extend- ed like rays of various colours, in different people ; but the concentrical orbicular fibres of the pupil are neither vifible to the eye, nor by the microfcope, not even in an ox, as far as I have been able to obferve ; only there is one diflindt ring of obfcure fibres in the body or in- ner margin of the uveal circle. In the numan fetus, and in chicklings of the egg, the pupil is clofe flrut ; fo that the iris extended, makes up a perfect circiil^?£l^in. The other part ot Of the Sight. 65 the circle which furrounds the pupil, is vafcu- lar. This by degrees contradls itfelf after the birth, and leaves a free paffage for the rays to enter through the pupil. §. 507. Behind the uvea, from the fame circle, by which the choroides and fclerotica join together and outwardly adhere to the cor- nea, arife thick ftripes, extended from the cho- roides, elegantly wrinkled with parallel veflels, fpread under them, which are conjoined by fea- ther-like loofe and thin footflalks, into the re- tina, every way fpread with a good deal of black paint, and departing, after the manner of a perforated ring, inward from the tunica cho- roidea, they fpread upon the vitrious humour ; and laftly, adhere to the capfule of the cryftal- line lens, and are called by the name of the n- liary ligaments. [The origin of the black pig- ment we are as yet unacquainted with ; nor can any glandules be found, which fome have af- figned for its feparation.] §. 50S. But the retina^ which is truly a con- tinuation of the medulla, from the optic nerve, is next expanded into a fphere concentric, with the choroides extremely tender, and almofl; of a mucous confiftence, diffolvable by a blaft ; and this immediately embraces the vitrious body. But when the retina has extended itfelf as far as the ciliary procefies, it follows their courfe, making their Ifripes and fmall arteries its, foundation or fupport, in its courfe to the cryftalline lens, to the^ capfule of which it adheres; and if we may believe the obfervations of: fome anatomifts, fpreads upon its furface. , To, my enquiry, there VoL. II. F . . ■ leems 66 Of the Sight. feems to be rather folds or plates than fibres, difiinguirhable in the retina. [It contains many Imall hlood-vefl'els, and is covered over by a white nervous fubftance, which is, by many, counted a proper membrane of the re- tina.] §. 509. Thefe coats of the eye, which In- vefi: and fupport each other, after the manner of an onion or other bulbous root, give a fphe- rical figure to the eye, and include its humours^ by which name are underftood commonly three fubflances, the one a folid, the other a foft body, and the third truly a liquor. Firfi; then, the common furface of the retina is, on all fides, filled by the principal or 'vitrious hu- mour, which is contained in a thin pellucid membrane of its own, of a cellular fabric, in the intervals of which is confined a mofi; clear liquor, a little denfer than water, which en- tirely evaporates by heat, like the aqueous hu- mour, from which nature it does not eafily de- generate, even in old people. [It has vefiels from thofe of the retina, which appear plainly enough in the eyes of fheep and oxen.] §. 510. But in the fore-part of the vltrious body, behind the uvea, there is an orbicular deprcffion or fnus connderably deep, into the cavity of which the crsfalline lens is received, though that be lefs properly ranked in the clafs of humours. The figure of this lens is made up of two elliptical convex portions or fides, the foremoft of which is flatter, and the pofierlor m.ore gibbous. The flrudlure of it is that of concentric plates or fcales, fucceeding each Of the Sight, 6 j fjach other, and compofed by the fibres them- felves, elegantly figured and contorted. Be- twixt the cryftaline leaves, is alfo contained a pellucid liquor, which, in old age, tarns to a yellow colour. The innermoft fcales lie clofer together, and form, at lafi:, a fort of continued nucleus, harder than the reft of the lens. [Its arterial veffels are continued through the vitreous body from thofe of the retina ■, and the veins re- turn in company With thofe of the ciliary liga- ment, §. 507.] This whole lens is contained in a ftrong, thick, elaftic capfule of a pellucid membrane, which is lined backward by tho uvea, and fuftained by the ciliary proceftes in- lerted into it (§. There is alfo acellular circle furrounding the lens, formed by the two plates of the vitrious membrane, the foremoft of which adheres to the lens by a broad cir- cle, and the innermoft is continued behind the lens, together with its capfule; by Vv'hich means a fpace is formed, which, by inflation, re- iembles a ring. §. 511. Laftly, the aqueous humour^ which is extremely clear and fluid, and renewed again, if it be let out, is feated ia a fmall fpace of a curve-lined triangular figure betwixt the uvea and cryftaline lens, and in a larger chamber that is before betwixt the iris and the cornea.. This humour feems to exhale from the fmall arteries of the iris, uvea, and ciliary proceffes, being again ablorbed into fmall veins of the fame parts while fome portion of it is drunk up and exhaled through the cornea. This F 2 humour 68 Of the Sight. humour alfo waters the uvea and capfule of the lens. §. 512. The eye, thus framed, is outward- ly furrounded with mufcles, for its government and diredtion. Namely, into the circle of the fclerotica, which is next to the cornea, are in- ferred four ftraight mufcles, arifing from the dura mater of the optic nerve at the bottom of the orbit, where, departing from the nerve, they cohere with the periofleum, forming, as it were, one circle ; from whence, going for- ward, their bellies lie round the bulb of the eye, and terminate again by their aponeurofes, meeting together in another circle into the fcle- rotica. Of thefe, the elevator is tne lead:, and the abdudtor the iongeft. The office of thefe mufcles appears very plainly in each of them apart, fince, being bent round the convex bulb of the eye, as about a pully, they muft, of courfe, elevate, deprefs, or turn the globe of the eye, cither to the nofe or to the temple. Moreover, two of them, ading together, may turn the eye in a diagonal becwixt the former >diredions, as upwards and outwards, upw'^ards and inwards, &c. Laftly, when all the four ftraight mufcles are contraded together, there is no doubt but they draw the wffiole eye to- wards its origin within the orbit, by which .means the cryftalline lens is moved nearer to the retina. §. 513. But the two oblique mufcles of the eve are of a more compound fabric ; the upper of thefe, arifing toge^er with the redi, is long and {lender, afcending forward to a notch in Of the Sight, 69 in the os frontis, which is completed by a double ligament, cartilaginous on each fide, and hollow in the middle, almoft quadrangular for fuftaining the tendon of the mufcle. Through this canal paffes the tendon of the obliquus fuperior, which being again refledled backward and downward, included in a cap- fule of its own, is inferted into the globe of the eye behind the ftraight mufcles. This draws the globe forward and upward, in a manner out of the orbit, that the eye may take in a larger field of vifion ; it alfo turns the pupil inward and downward. The other lefjer oblique mufcle, arifing from a finus of the lacrymal foramen in the upper jaw, af- cends immediately outwards from the os uh- guis round the globe of the eye, and is in- ferted by its tendon into the fclerotica behind the external redlus ; whence it appears, on its part, to turn the eye downward and outward, and of courfe contrary to the former to diredl the pupil upward and inward. §. 514. But there are other more minute mufcular motions performed in the eye, which pre-fuppofe a knowledge of the nerves be- longing to this organ. And firlt, we have already fpoke of the optic nerve (§. 503, 504.). The fourth pair goes only to the larger oblique mufcle, and the fixth pair belongs to the exter- nal redtus. The third and fifth pair produce the principal nerves in the eye; and of thefe, the firfl; branch of the fifth produces the oph- thalmic nerve, and fends off a fmall nerve from its entrance into the orbit, to the eye-lid and F'3 lacry- 70 Of the Sight. lacrymal glandule 5 it then conjoins with the fecond branch of the fifth pair, and with the temporal branch of the third and fifth pair. Af- ter having ^entered into the orbit, its trunk di- vides into two j of which the upper and larger fubdivides into two, which are fpent upon the forehead and eye- lids 3 ’'ut the lower, going inwards above the opt;''' nerve, fends out long flender filaments to the outer part of that nerve, which, joining with another filament of the third pair, makes up the ophthalmic gan- glion. Finally, having given off a nerve, run- ning to that of the nofe (§. 45^.), it is then fpent upon the parts of the internal angle of t^e eye. §. 515. But the principal dignity of the third pair lies, in giving off a branch upwards to the flraight mufcles of the eye, and to the eyerlids j and then, going forward with its trunk under the optic nerve, it fends out three branches together to the lower and lefs oblique, and to the internal flraight mufcle 3 after this, or often before, (from its trunk, andfometimes from a branch of the lower obliquus) afeends out another fliort and much thicker nerve, which fometimes joins the root of the fifth (§. 514.)} or is fometimes folitary, which, under the abdudlor mufcle, conftantly forms the oval opthalmic ganglion. From that gan- glion, and fometimes from the trunk of the third or fifth, go out four or five ciliary nerves in a crooked courfe, playing round the optic nerve in their courfe to the globe of tl>e eye, yvhere they enter .the fclerotica almofc in its '• •• middle;, Of the Sight. 7 1 triiddle, in company with its longer fmall ar- teries or veins ; and running thence hraight forward through the choroides, they pafs vi- iibly to the iris, and feemingly to the ciliary proceffes. Upon thefe nerves, depends mani- fedly the feniibllity of the iris, which con- tracts itfelf in all the Wronger degrees of light, and dilates , itfelf in all the weaker degrees ; and from thence too the pupil is enlarged, in viewing all remote objeCts, as it is contracted fmaller when we look at things very near the eye. The caufe of the dilatation feems to be an abatement of the powers refifting the aqueous humour ; as we fee, for example, in the dila- tation that enfues from weaknefs, fainting, cr death. The conflriClion is, indeed, more ob- fcure, or perhaps arifes only from a ftronger influx of humours into the colourlefs veffels of the iris, by which the faid veffels are extended together with the iris, tvhich is thereby elon- gated, fo as to flmt up the greater part of the pupil. In children, the pupil is more fenfible, and more evidently contraCled or dilated ; but in old people, the parts of the eye, growing callous, it becomes, at lad, almod immove- able. Other fmaller nerves are extended from the fame ganglion to the fclerotica. §. 516. Another more obfcure and lefs eafdy demondrable motion in the eye, is that of the ciliary proceffes (§. 507.), which, lying in- cumbent upon the furrows of the vitrious membrane, feem, by their aClion, to prefs back that body, fo as to bring the lens forward, and feparate or remove it farther from the retina. F • 4;- [As 72 Of the Sight. [As for any fphindter of the pupil, or a con- flridor of the cornea, mentioned by fome writers of note, or even moving fibres, which others have imagined proper to the cryftalline lens, they are in no wife fupported by anatomy, nor are they confiftent with the perpetual hard- nefs of texture, obfervable in the lens and cor- nea of moft animals ] §.517. Moreover, to the hifi:ory of- the eye, belongs a defcription of the veflels, which, in this part, have a beautiful fabric. But all of thofe which belong properly to the feveral parts of the eye itfelf, come from the ophthal- mic artery^ a branch of the internal carotid (§• 33 ^ )- This, creeping along under the optic nerve, fends out, as principal branches, the upper and lower ciliaries, one or more ; the lacbrymalis, from whence the pofterior running to the nofe, and internal part of that belonging to the arch of the tarfus; afterwards the mufcu- laris inferior, the anterior recurrent to the nofe, the uppermofi: mufculares, and the palpebralis; from whence, with the former branch, fprings the arch of the tarfus. LalHy, it goes out for- ward to the face and adjacent parts of the nofe. But the ophthalmic branches, belonging to the inner fabric of the eye, are the pofterior and middle ciliaries, which, arifing from the trunks before- mentioned, and playing round the optic nerve, in four or more branches, in a ferpentine courfe, go partly in with the optic nerve at its firfi: entrance, and are partly extended further to near the middle of the fclerotica, where they fend in twenty or more little arteries to the cho- of the Sight. 73 choroides, which make firft beautiful ramifi- cations upon the external furface of that mem- brane, round and like the branches of trees; from whence they proceed inwardly in a more diredt courfe, and extend fome of their branches as far as the cohefion of the iris, with the cor- nea and choroides (§. 506.) ; and here each branch, dividing to the right and left, and in- termixing with others of the fame kind, at lafi: go to complete the arterial circle of the uvea. §. 518. But to the compofition of the fame circle, concur many other fmall arteries ; as the anterior ciliaries^ which, arifing from the muf- cular branches of the ophthalmic, hear the origin of the pellucid cornea, perforate the fclerotica by twelve or more branches, and to- gether make up the circle of the pupil. From that circle, and likewife from the fore-men- tioned arterial ciliary arteries, independent of the middle circle, are diftributed veffels, both on the anterior face, which makes the iris, and on the pofterior face of the uvea, toge- ther with the ciliary procefies ; the veffels are diftributed, both ftraight and ramified ; the iris is full of a liquor of a bluilh colour, other- wife brown ; and the uvea is fpread with a good deal of a black paint, without v/hich it is na- turally white, and fends fmall pellucid branches even into the chryftalline lens, as I have truly feen. §. 519. But from the fame ophthalmic and its trunk, or from the lacrymal branch, or from one of the ciiiaries, one or more branches enter into the optic nerve ; the principal of thefe. 74 0 / Sight. thefe, being fingle, penetrates through the me- duila of the nerve, and, going out of the middle or apex of the papilla (§. 504.), divides in the center of the retina, from thence fpread- ing its branches every way in company with the retina itfelf. Sometimes a fecond or leffer branch goes along the center of the nerve to the retina, and is, in like manner, ramified through it. It is probably from thefe branches, that the minute pellucid ones of the vitrious tunic are produced. The center of thefe ar- teries, entering the retina, is the celebrated poriis opticuSy or blind point of the antients. §. 520, The veins of the eye, in general, being branched like trees in the choroides, conduce but little to the formation of the circle of the uvea. They arife from the ophthalmic vein, which here comes from the vein of the face, and, going cut of, or under the bony or- bit, is inferted into the cavernous finus. The internal veins of the eye are fewer in the mid- dle of the fclerotica, which they perforate with larger trunks, and form buflies or trees, fome- v/hat bigger and more anterior than thofe of the arteries ; and another vein perforates the center of the optic nerve, and is fpent in the retina like the artery. The pellucid or watry vefl'els differ not in their courfe, from thofe which convey blood. There are alfo lympha- tic veffels faid to have been feen by feme in the retina, but the obfervation has not been often enough repeated for us to depend on. §. 521. So far, with refped: to the anatomy of the eye i but tlaat the action of this organ lies Of the Sight. 75 lies wholly in the reception of light, excepting only a few doubts, appears very plainly from phyfical and mechanical experiments. Light then is a matter either the fame, or very nearly approaching to that of fire (§. 2.), extremely fluid and fubtle, penetrating through all even the hardefl; bodies, without receiving altera- tion from any length or diflance in its courfe, moving with fuch a very great velocity, as to run through the great orb to us in the fpace of about fixteen minutes and an half. The light we have in our atmofphere proceeds ei- ther from that of the fun, whofe body feems to have the power of impelling to us, in right lines, the matter of light, which is confufedly fpread around, or elfe it proceeds from foms other ignited point or lucid body j from v/hence the rays fpread every way, as from a center to all points of a large fphere, fo as to fall upon the furfaces of bodies ; from whence again it is refledfed into the eye from the enlightened furfaces in angles, equal to that of their inci- dence, fo as to render the bodies, from whence it thus flow to the eye, both vifible and of fome colour. §. 522. It is nov/ fufficiently evidenced from experiments, that light is compofed of rays in right lines, almoft without any phyfical breadth or thicknefs, and yet that each of. thefe rays are again feparable into feven other permanent and immutable rays of a leflTer kind. The known properties of thefe rays are, that all of them, conjoined together, conftitute a white v/hich, being refraded by the minute furfaces 7 6 Of the Sight. furfaces of bodies, are fubdivided into rays of a red colour, which are more conftant or per- manent, hard and lefs refrangible; next to which follow thofe of an orange, of a yellow, green, blue, and indico or violet colour ; of w^hich thofe are always weaker and more refran- gible, w’hich are farther diftant in order from the red rays. A fbadow arifes from a deficiency in the rcfledled rays. Thofe primitive rays, va- rioufly compounded together with (hade, make up all the variety of colours. The colours then, which feem proper to bodies, arife hence, that the minute furfaces of their conftituent folid particles, by which their pores or va- cuities are limited, do, according to the diffe- rence of their thicknefs, denfity, &c. refledt or feparate the rays of light, fo as to fend more of one kind or colour to the eye than another ; whilft moft part of the remaining rays are loft by repeated refledions within the pores of the fubftance, fo that the ftrongeft and thickeft particles refled a white colour ; thofe next, in denfity and fize, a red colour, ’till at laft the minuteft furfaces refled a violet colour. Thofe bodies are opake, which retain the rays with- in their fubftance, without permitting any to pafs through them ; which feems to follow from the largeivefs and the number of the pores, to the fides of which the light is attraded, which pores are filled with fome matter that has a power of refradion, difi'erentfrom that which the light fuffers from t^e parts of the body it- felf. [Thefe principles we embrace ’tiil a new tiicory, that places the diveriity of colours. Of the Sight, yj like thofe of founds, in vibrations of different celerities, fliall be better eftabliihed j although, in reality, we are but little concerned, as to our experiences, in this or any other theory.] §. 523. Thefe rays, falling obliquely upon the furface of liquors of various denfities, pals through them with a change in their diredtion, by varioufly receding from, or approaching nearer, to a perpendicular ; and this is called their refraction. In general, the denfer the medium, the more are the rays bent towards the perpendicular, excepting only inflammable liquors, which, by a peculiar property, draw them more to a perpendicular, than in proportion to the denfity of the liquor. The proportions of the angles of incidence, to thofe of re- fradtion, are obferved to be conftant enough, fo that the line of the radius of refradtion from air into water is to the line of the angle of in- cidence, as 4 to 3 5 and in the radius, palling from air into glafs, the fine of the incidence is to that of refradtion, as 1 7 to 1 1 ; and from water into glafs, as 51 to 44. §. 524. Rays, which come through the air with but little divergency, (as do thofe of the fun on account of their immenfe diffance, or as, in general, do any rays that come from the diltance of above 100 feet) falling out of the air upon a denfer body, are fo refradted, as to meet together in one point, which is called their fccm j and this point always falls within the axis or radius that is perpendicular to the furface whence it becomes permanent and unchangeable, fo that the focus of rays, paf- ling Of the Eight. fmgfrom air intoafphereof water, will bediftant from the axis one femidiameter of the fphere* And in a globular glafs, it will be diftant a fourth part of the diameter; but in a convex lens of glafs, that is part of a fphere not lefs than thirty degrees, and equally convex, the focus will be likewife diftant one femidiameter, yet fo that the rays will meet not in a fingle point, but in a little circle. §. 525. Therefore the rays of light, whe- ther diredl or infiedled, fall, in fuch a manner, upon the tunica cornea of the eye, as to form ' a mofi; fharp cone betwixt the lucid point and the membrane upon .which they are fpread. The bafis of which cone 'will be the furface of the cornea, and the apex in the radiant point, yet fo that every ray in this cone may, without any fenfible error, be reckoned parallel with each other. Among thefe, there are fome rays refledted back from the cornea, without ever penetrating the furface ; namely, all fuch as fall upon that membrane, in a greater angle than that of forty degrees ; and other rays, which enter the cornea, at very k/'ge angles, but lefs than the former, and fall in betwixt the uvea and fides of the cryftalline lens, are fuffocated or loft in the black paint that lines the uvea (§. 506.), and the ciliary proceftes (§• 5^7‘) 5 thofe rays only fall upon the furface of the lens, which enter the cornea at fmall angles, not much diftant from the per- pendicular, or at moft not exceeding twenty- eight degrees. By this means, all thofe rays are excluded, which the refrading power of 2 the Of the Sight. 79 the humours in the eye could not be able to concentrate or bring together upon the retina ; without which they would paint the objedt too large and confufedly. §. 526. Thofe llender rays, therefore, com- ing thus to the thick cornea, which is denfer than water, and forms the fegmsrit of a fphere, fuffer thus a greater power of refraction, and pafs through it in a more confiderable degree towards the perpendicular, namely,, about a fourth part ; but thefe rays, falling with but little convergency upon the aqueous humour, which is fmall in quantity, and almofl like wa- ter, making there no focus, becaufe of the nearnefs of the humour to the cornea, go on nearly parallel, or little converging to the next adjacent furface of the very pellucid or cryftalline lens ; becaufe their divergency was conhderably corrected by the refraCting power of the cornea. Moreover, the cornea, being convex, and part of a kfs fphere than that of the fclerotica, receives and colleCls a greater number of rays, than if it was flatter, with a lefs furface. §. 527. The refracting power of the cryflal- line lens, which exceeds that of water, may be underflood, from its greater hardnefs, den- flty, or weight, which, by fome certain expe- riments, is computed to be equal with the re- fracting power of the diamond, fo as to make the refracted angle half that of the incidental 5 or, by other experiments, if the lens be com- pared with glafs, its refraCtion will be fome- what lefs namely, about ons and an half. In this 8 o Of the Sight. ^ this lens, therefore, and more efpeclally in its pofterior very convex fide, the rays will con- verge much together, and pafs thence into the vitrious body. §. 528. This vitrious body is denfer than water, in which it finks to the bottom, but rarer than the cryftalline lens, and continues to bend the rays towards the perpendicular, ’till, at length, in a well-formed eye, the rays, coming from the point of diftind; vifion, are concentrated into a very fmall part of the re- tina, where they paint an image of that objedt from whence they comej but in a pofition inverted, from the neceffary decufiation or crofllng of the rays. The manner, in which the images of obje£ls are thus painted, may be feen experi- mentally in an artificial eye, or by a natural eye, when the back- part of the fclerotica is cut off, and a piece of paper placed to receive the objeft. But the image we fee is painted on the outer fide from the optic nerve, within the bounds of the vifual axis, yt' fo that it is not a mere point, but has fome degrees of breadth ; fince we fee many objedts at once, whole images muft be in difiindt points of the painted field. And there an objeftis feen the more di- ftindl, becaufe the rays arrive thither nearly perpendicular. But frequently this point of vifion does not fall on the fame place in both of the eyes. [When the lens has been couched or difplaced, the vitrious body with a weaker refrading power, ufually fuffices to bring the vifual rays together, to a focus.] §■ 529- Of the Sight. 8 r §. 529. But fince the necefTary offices of human life require a diftincft objed: to be paint- ed upon the retina, not only by the rays which come from one certain diftance, but likewife by rays which come from very different parts, more or lefs diftant ; therefore nature has made the lens moveable by the powers be- fore-mentioned (§.512, 516.) j for, without this motion of the lens, we fee objeds that are either remote, or very near, after a man- ner, indiftindly. [This art of feeing diflind- ly, we learn by experience, it being unknown to an eye lately couched of a catarad.] Alfo, in an artificial eye, the ufe and neceffity of this motion may be plainly perceived. Therefore too great a divergency of the rays, as in thofe which come from objeds very clofe to the eye, is correded by a removal of the lens farther from the retina, fo as to bring the focus of the diverging rays upon the retina itfelf, which would otherwife have fallen behind the eye ; for the refrading power of the eye being de- termined, that, which will unite the focus of rays, coming from the diflance of three feet, fo as to make them fall perfedly upon the re- tina, will not be able to colled together into the fame point, thofe rays which come from the dffiance of three inches ; and rays ftiil more diverging will meet together yet far- ther behind the eye, if they are not colleded together by a greater refrading power. §. 530. But thofe rays, v/hich come from parts very remote, and v/hich may be, there- fore, counted parallel, will meet together be- VoL. II. G- fore 82 Of the Sight. fore the t:etina, in the vltrious body, and again feparate according to the nature of rays from the point of concourfe, as if it was a lucid point; to remedy which, therefore, thofe powers (§. 5 i6.) remove the cryftalline lens back from the cornea, nearer to the retina, that the rays, which come together from a certain diftance to the lens, may be alfo united together, at a certain proportionable diftance on the retina. For an eye, that will colled: the rays, coming from feven inches, fo as to unite them on the retina, will colled thofe together, fooner or before the re- tina, which come from three feet. It was, there- fore, perfedly neceftary for the eye to be made thus changeable, that we might be able to fee diftindly at various diftances. But the point of diftind vifion is in that part of the retina, where the given objed is painted in the leaft compafs pofiible. [The powers, caufing the vifual rays to unite or converge together on the retina, are often very different in the two eyes of one and the fame perfon, fo as to render one eye nearly prefbyoptical or long-fighted, and the other myopticai or fhort-fighted.] §.531. But this artifice (§. 529.) of the eye is, however, not alone fufficient in all peifons. For there are now a greater number of people than formerly employed in a ftudious or fe- dentary life, and taken up with the obfervation of more minute objeds, by whieh the cornea is rendered more convex and denfe, and the cryftalline lens more folid and of Ids fegments, while the eye itfelf, by the weight of the hu- mours, is more elongated, and the reft of the liumours themfelves are probably more denli- Of the Sight. 83 fied ; rnany or all of which circumftances at- tend the eyes of one perfon. In fuch, the iris is fenlible in a fmall lightj whenccj by wink- ing or {training the eye-lids, they are deno- minated myopes, (hort or near-fighted j in thefe, the point of diftind: vifion is very near to the eye, from one to feven inches from before the cornea j but they fee remoter objedls more ob- fcurely, without being able to diftinguith their parts. The rcafon of this is evident, lince, from the fore-mentioned caufes, there is a greater refradting power of the humours, by which the diftant, and confequently parallel fays, are obliged to meet in their focus before the retina; from whence, fpreading again, they fall upon the retina in many points. Thus alfo to a good eye, the fenfe of objects, which are too near the cornea, is confufed, becaufe the rays, coming from thence, are fpread all over the retina, without being colled:ed to- wards the center. §. 532. The remedy for this fault in the fight is to corredl it in its birth or beginning, by viewing diftant places, by keeping the eyes from minute or near objedts, and by the ufe of concave glaffes, or by viewing things through a fmall hole, by which the light is weakened. When the diforder is confirmed, the remedy is a concave lens, which takes off a degree of the refradting power in the humours, cornea, and cryftalline lens, in proportion, as it is more concdve, by which means the focus of rays, from remote objects, is removed farther behind the cornea, ib as to fall upon the retina. This G 2 glafs ^4 Of the Sight. glafs ought to be a portion of a fphere,> whofe diameter is equal to the diftance of di- ftindl vifion from the naked eye, fquared by the diftance of diftindt vifion in the armed eye, and divided by the excefs betwixt them., [Age itfelf advancing, gives fome relief to the fhort-fighted j for children are, in a manner, naturally myoptical : but, as the eye grows older, it becomes flatter, in proportion as the folids grow ftronger, and eonfradling to a fhorter axis, the converging powers of the lens and cornea are diminifhed.] §. 53 3. Another diforder of the fight, con- trary to the former, troubles people, who are often looking upon very diftant objedts, and is more efpecially familiar and incurable in old people i whence the perfon, thus difordered, is called prejbyopus. In fuch a one, the cornea and cryftalline lens are flatter, and the humours of the eye have a lefs refradling power. Hence near objedls, whofe rays fall very diverging up- on the cornea, appear confufedly, becaufe the converging or refradling powers of the eye are not fuflicient to bring the rays together in a focus upon the retina, but the rays go on fcat- tered through the retina, and throw the point of their pencil behind the eye ; from whencq vifion is confufed. The point of diftindl vifion, among prelbyopi, or old or long-fighted peo- ple, is from the diftance of fifteen to thirty mehes. §. 534. Such perfons are, in fome meafure, relieved by looking through a black tube held before the eye, by the ufe of which the retina i grows Of fheSighC 85 grows tenderer, and the rays come in a more parallel diredion. The remedy here is a con- vex lens of glafs, which may caufe the rays to converge and unite together fooner in a focus, that it may fall not behind the eye, but upon the retina. The diameter of the fphere, of which fuch a lens ought to be a portion, is de- termined as before, (§. 532.) §. 535. The medium betwixt fhort and long-lighted is the beft, by which a perfon ca« fee diftindly enough objedls, that are both near and remote 5 and of this kind we reckon an eye, that is able to read diftindlly at the di- ftance of one foot. But to this are to be ad- ded other necelfary conditions, fuch as a per- fedl clearnefs of the humours, a due mobility of the eye itfelf, and its parts, a fenlibility of the pupil and retina, neither too tender nor too tough. §. 536. But the mind not only receives a re- prefentation of the image of the objedl by the eye, imprefled on the retina, and transferred to the common fenfory or feat of the foul j but Ihe learns or adds many things from mere ex- perience, which the eye itfelf does not really lee, and other things the mind conliders or in- terprets to be different, from what they appear to her by the eye. And firll, the magnitude of an object is judged of by an optical angle inter- cepted, as the balls of a triangule betwixt the cornea, and as the point of a cope betwixt the radiant objedt:. From hence, things very near feem large, and remote objedls feem fmall. Hitherto may be referred the power of micro- G 3 fcopes^ 86 Of the Sight. fcopes, by which objeds are made to appear to us fo much larger, as the diftance of the fo- cus of the lens or magnifier is lefs than the di- ftance of diftindt vifion; when, in reality, they do not appear larger, only more diftindl and lucid} whence the mind judges them to be larger or nearer. §. 53 7. The ftrength of vifual light likewife js proportionable to the fame angle, in the ex- ternal day-light} and the multitude or number of the rays, joined with the fmallnefs of the feat, which they affedl in the retina, occafions near ob- jedts to appear brighter, and diftant objedls more obfcure ; or if a remote ohjedl appears bright by its own light, the mind reprefents it either as one large, near at hand, or both. §. 538. p'ace a diftant objedl appear- ing to the eye, is eftimated by the concourfe of two lines, drawn from the center of the feeing eye, ’till they meet together, or join in the Ipace that lies betwixt the point in which the objedl appears vifible in the right eye, to the fame point in the left eye } which, lines, if they no where interfedt each other, will reprefent the objedt double, or, if they meet upon each other, we place the feat of the objedt in the point of interfedtion. B^itdifance we are not able to fee, only we judge of it from the _ diminution of magnitude before known, as Well as from the angle intercepted betwixt the two optical axes, together with the weaknefs of the light, and palenefs or faint- pefs of the image, coming from the objedl in conjunflion yv;ith the number of interme- diate Of the Sight. 87 diate bodies, whofe diftances were before known to us. But we find all things are fallacious, that are not founded in the infallible wifdom of the creator, but arife by experiences in the judgments of mankind. §. 539. Thus the convexity or protuberance of a body is not feen, but is afterwards judged of by experience, after we have learned, that a body, which is Convex to the feeling, caufes a certain mode or habit in light and (hadow. Hence it is, that microfcopes frequently per- vert the judgment, by tranfpofing or changing the fiiadows. §. 540. The vifible Jifuation of the parts of an objedt are judged by the mind to be the fame with that which they naturally have in the objedt, and not the inverted pofition, in which they are painted upon the retina. But k is certainly a faculty innate or born with the eye, to reprefent objedls upright to the mind, whenever they are painted inverted upon the retina : for new-born animals always fee things upright, and are never miftaken in enquiring for their mother. And men, who have been born with cataradls, without ever being able to fee, are obferved, upon couching the cata- radls, to fee every thing in its natural fituation, without the ufe of any feeling or previous ex- periences. §. 541. One thing, which impofes upon the mind, is, the continuance which external fenfations make, during almoft the fpace of the fecond of a minute, after they have been con^ veyed to the fenforlum by the eyes j whence G 4 they 88 Of the Sight. they are reprefented to the mind, as objeds really prefent. From hence proceeds the idea of a fiery circle from the circumrotation of a lucid body ; and from hence proceeds the con- tinuance of the fhining image of the fun, and fometimes of other bodies, after they have been viewed by the eye. §.542. If it be queftioned by fome, whe- ther it be true, that the objedl is painted upon the retina ? or whether this painted image be not made upon the choroides ? or whether this new opinion be not confirmed by the ex- periment, that fliows the part of the eye to be blind or infenlible, where the optic nerve enters Into it ? and whether this be not explainable, becaufe no choroides being there, the naked retina is incapable of feeing ? we anfwer, that this late fuppofition is inconfiftent with known obfervation, by which the retina is evidently a rnofi; fenfible expanfion of the nerve, while the choroides has only a few nerves, with fmall veffels, w^hich are certainly blind. ’Tis alfo oppofed by the great variety of the cho- roides in difierent animals, while the conftant uniformity of the retina is equally as remark- able j to which add the black membrane, that is interpofed betwixt the retina and choroides, in fome kinds of fith. Finally, anatomy de- monltrates, that the choroides is feated in thq blind part of the eye, but of a white colour. Moreover, from this experiment, we have a reafon, why the optic nerve is inferted on one fide, and not in the optical axis of the eye. For thus, excepting one inftance, when there Of the Sight. S9 is any objedt in the interfedion of lines drawn through the center of the optic nerves, it is always feen by one eye, that it may be able to aflifl the other, whofe blind part is turned towards the objed. §. 543. Whether we can fee but one objed: diftindly at a time, and that placed diredly before the retina of the eye that fees diftindly? and whether the mind perfuades herfelf (he fees many objeds, partly from the continuance of the ideas they excite, and partly from the ce- lerity of the motion in the eye ? we anfwer in the affirmative, with refped to diftind vifion ; but it would be too much to afkrt this, with refped to indiftind vifion. If it be demanded, from whence proceeds the blindnefs, that hap- pens to fome in the day-time, and to others in the night ? we anfwer, that the nodurnal blindnefs is familiar to many countries in the hotteft climates, and to old people, who live under a very hot fun •, but the diurnal blindnefs is familiar to thofe who have inflamed eyes, and to young perfons of an inflamed habit, whofe eyes are, therefore, extremely tender. Thus the one is produced from too great a tendernefs of the retina, as the other proceeds from an hardnefs or infenfibility of it. Whence proceeds the nodurnal fight of animals ? from a large dilatable pupil, from a tender retina, and from a ffiining choroides, flrongly re- fleding the light. Whence is it, that we are blinded by paffing from a light into a dark place ? becaufe the optic nerve, having fuffered |he adion of ftronger caufes, is, for the pre- Of the Sight. fent, lefs afife ■ ' LECTURE XXI. Of Hunger y T^hirf^ Food, and Frink. 579 * '' E fee the creator has given to man the two faithful guards of pleafure and pain (§. 551.) for his prefer- vation ; the one to avert evil, the other to in- vite him to ufeful actions. Frorn hence w’e are informed, that the taking , of aliment is aii action neceffary and ufeful to our fupport. For iince every day there is a great quantity wafted from the body, by a diffolution of its true fub- ftance, thrown off by the perfpiration and other difeharges, a repairing of the faid lofs is every way neceffary ; but more efpeclally this is de- manded from the aliment, by the nature of the blood itfelf, ftrongly inclined to a ftiarp, fa- linej iixivial quality, and to a putrid acrimo- nious ftate, to which it is continually follicited, and approaches from the putrefeent difpofitioh of ail the more fta2:nant humours of the ani- ma], promoted by the iqceffant and natural mo- tion of the heart and arteries, with a perpetual lieat. Moreover, the coagulable dlfpoCtion of the blood, pontinually lofing a great part of its diluting water, by infenfible perfpiration, calls ilrenuoufty for a recruit of the watry element, in the way of drink, by which its cohefive globules are feparated from each other, and hindered from running together into aconfiftent §. 580. 'appetite and AVunenfs. 1 19 580. Thefe truths are proved not only ixotn their caufes, but likewlfe by their efFed:s and appearances, which they exhibit in men and other animals killed by hunger ; for, in fuch, we commonly obferve a fliarp ftinking breath, a loofenefs of the teeth, from the dif- folving acrimony of the juices, violent pains in the ftomach, a (harp fever, and even a true madnefs. All thefe diforders arife fooner and ftronger, as the perfon is more robuft and more violently exercifed with motion of body-, but they enfue very llowly in phlegmatic people, who are unadlive, perfpire little, and put the blood into no great motion. §.581. The frelh chyle, compofed, for the moft part, out of the acefeent clafs of vege- tables, and of a confidence always thinner than that of the blood itfelf, being received into its torrent of circulation, ferves to temperate the putrefeent acrimony, to dilute or leffen the coagulation threatened, and reduce the whole mafs from a fliaro faline to the mild albumi- i nous nature, which is proper to healthy blood j and finally, the chyle, but more efpecially that derived from the flefh of animals, being re- plendhed with gelatinous lymph, ferves to re- pair the confumption or wade which is made from the body itfelf, to the vacuities of whofe broken folids it is applied, by the caufes before- mentioned (§, 240.). But the drink chiefly dilutes the cohefive or grumous inclination of the blood, hinders its putrefeent acrimony, and carries off, by the emundories, fuch particles as are already putrid j and hence it is,' that a I 4 ' perfon 120 Appetite and Aliments, perfon may live for a long time without folld food, if he be but fupplied with drink, even of water. §. 582 We are follicited to take food, as well from the fenfe of pain we call hunger, as from that of pleafure, which is received by the tafte (§.4:; 6,). The fir ft of thefe proceeds, doubtlels, from the fenfible folds or wrinkles of the ftomach, rubbing againft each other by the periftaltic motion, joined with a prefture from the diaphragm and abdominal mufcies, by which the naked villi of the nerves on one fide grate againft thofe of the other, after a manner intolerable. Thus we are effedlually admoniftied of the dangers enfuing, from too long abftinence or fafting, and excited to pro- cure food or nourifhment by labour and in- duftry. To this fenfe alfo, the gaftric liquor or juice of the ftomach, collecfted and fharpened after feeding, does, in fome meafure, conduce. §. c; 83. Thirft is feated in the tongue, fau- ces, oefophagus, and ftomach, For whenever thefe very fenfible parts, which are conftantly and naturally moiftened by mucous and falivaj juices, grow dry, from a deficiency of thofe or the like humours, or are irritated by a re- dundancy of muriatic or aicalefcent falts here lodged, there arifes a fenfe much more intole- rable than the former, as thirft is more dange- rous ; whofe uneafy fenfe continues, until the proportion of diluting water in the blood, being recruited, reftores the necelfary moifture and free,fecretIon required In the parts before-men- ^ioped. From hence we learn, why thirft at- . • ' ' : • tends Appetite and Aliments. 1 2 1 tends labour, which exhales a greater propor- tion of the watry perfpir-ation ? and why it is a fymptom of fevers ? where there is a drynefs and obftrudlion of the exhaling veffels belong- ing to the tongue and fauces ? why fimple wa- ter, having no tenacity, will often not hick long enough to the juices to abate thirfl:, which yields, neverthelefs, eafily to fome acid liquors, that not only moiften and render fluid, but alfo neutralize and provoke forward the hu- mours. §. 584. From thefe caufes, mortals, being under a neceifity of feeking food for the flip- port of life, have, from the beginning of ages, determined their choice to the fucculent parts of vegetables and animals, in fuch a manner, that water and fait leem to be added onlv as j third afljftants. And firfl, it is probable, that the primitive choice of our foods was made -by experiments, according as the variety of fmelis gind flavours, in vegetables and their leveraj parts invited, and as the flrength or recruit of our faculties thence following, confirmed their utility. But, by degrees, animals increafing, fo much as to be incommodious to man, now declining in his conflitution or longevity, the flefli of animals was afterwards added, as a better flipport for thofe labours, which could pot be fo well fuffained by vegetable food alone. At prefent, both the number and variety of fubflances are almofl infinite, which we take either as food or feafoning for our nourifh- ment. I §> j8j. 1 22 Jppetite and jdliments. §. 585. Although there are many Inftances of particular perfons, and even of whole nations, who have fupported life only with one kind of food, either vegetable or animal, or even from fmall clafs of either of them : and although -fome have lived altogether upon milk or its whey, yet it feems to be neceffary, both from the nature and fabric of the human body itfelf, as well as from the known effects that follow from only one kind of food, that we ought to fupport life by the two kinds of foods, both animal and vegetable, fo intermixed, that nei- ther of them may exceed their reafonablc bounds ; and this mediocrity we are tauo-ht from the loathing itfelf, which follows to any one kind of food that has been continued for too long a time together. §. 586. The fledi of animals appears a ne- ceil'ary part of our nourifhment, even frop the fabric of the human floma.ch itfelf, refembling that of carnivorous animals ; and from the two rows of teeth, with the canine teeth in each jaw ; alfo from the fmallnefs and fhortnefs of the inteftinum c$cum, and from the neceffary vigour which we require, and which is more remarkable in carnivorous animals. For it appears, that the flefli of animals only contain the gelatinous lymph, ready prepared for the recruit both of our fluids and folids, which, being extradled from the broken veflels and fibres, is readily converted into abundance of blood. An abflinence from animal food, in thofe who have been accufliomed to it, gene- rally caufes great weaknefs both to the body '/Appetite and AUments. iij and ftomach, being perpetually attended with a troublefome diarrhoea or purging. [But in the amplitude and length of the inteftina cralTa, man agrees with herbivorous animals.] §. 587. Efculent vegetables are generally of the acefcent kind, only fome few of them are either alcalefcent, or elfe repteniihcd with a Ipicinefs ; but none of them have that animal glue, which is fpontaneoufly changeable into blood ; for it is only the fmall portion of jelly, which is drawn from their farinaceous parts, which, after many repeated circulations, is converted into the nature of our indigenous juices. Yet thefe are necelTary to avoid over repletion with blood, and of too putrefcent a kind from the ufe of animal food alone, which, from the mod creditable accounts of the an- thropophagi, prevails to fo great a degree, as to breed the hot alcalefcent feurvy, a herce or lavage tern'per, a {linking and leprofy of the body, with' adixivial Corruption of all the juices, Vvhich are only to be avoided or cured by change of diet, in which a vegetable acidity abounds. Hence it is, that we are furnilhed but with few canine teeth, and our appetite in health, but more efpecially in dlfeafe, is llrong- er for acidulous vegetables, in proportion to our warmer temperature of body, and greater heat of the country or the feafon of the year. Hence we fee, that, in the hotteft climates, people live either altogether upon vegetables, or ufe flefh meats but very rarely, and not without danger of acute difeafes ; while, in the colder countries, de(h is ca'; freely with lef§ danger: and 124 Appetite and Aliment i, and hence bread, or fomething like it, is made a {landing part of our food throughout the world. §. 558. The bed; drink is afforded by pure water, not incorporated with falts nor with air, by which it may readily enter into a fer- mentation. Of this kind, we juflly prefer that from a mountainous fpring, which runs clear and cold through a fandy bed, being very light and infipid. Whenever we are unprovided with fuch pure and healthy water, as is fre- quently the cafe in the lower flat countries, or when any increafe of the dirength and mufcular conftricfrion of the flomach is required, from a fpicy flimulus, its place may be very well fup- plied by wine, prepared chiefly from grapes, but in defe£l of thofe, from apples and pears, which, after a due fermentation, becomes clear, and is replenifhed with an acid fait, and oily or inflammable fpirit, well diluted in water. Liquors of the fame kind, replenifhed with a vinous or inflammable fpirit, but more flatu- lent, heavy, and lefs palatable, are prepared from the feveral kinds of corn opened by ma- ceration and flight roafting, afterwards extradled with boiling water, and prepared, by fermen- tation, as a fubfritute for wine to thofe coun^ tries where the grape does not ripen. §. 589. But mankind has invented various pickles and fauces, fuch as fait, vinegar, and acids of various kinds, to corre(ft the putrefeent difpofltionof ficfli meats, with pepper, muftard, and other hot fpices, to flrengthen the action of the flomach, which is perpetually wakened appetite and Aliments. 1 2 5 by flatulent vegetables j and to thefe add, the fugar, fait, and eaftern fpices, which are ge- nerally added either for the fake of flavouring or preferving our food. But all thefe yield no nourifliment, being dellitute of all gelatinous lymph, or any farinaceous quality. §. 590. The aliments are generally drefled, or varioufly prepared, according to their diffe- rent nature, the country, feafon, &c. by which their crudity is removed, their folid fibres foft- ened or opened, their too much incorporated air expelled, or their difagreeable acrimony re- duced or changed to a flavour that is agreeable. But even after this, many vegetable foods, and more efpecially flefli meats, require to be di- vided, in fome degree, by a previous triture in the mouth, which is more efpecially ne- ceffary in man, whofe ftomach is very thin, or but little flelhy, and likewife that the food may not ftay fo long upon the ftomach as to become putrid. [Therefore we are naturally led from the confideration of the aliments themfelves, to that of their maftication.] LEG- 126 LECTURE XXIL Of MaJUcation and the Salha. §. 591-0 UCH hard and tough foods, as confift of long parallel fibres, or are covered with a bony (hell or cartilaginous' lldn, generally require mafticatlon, to divide them into lefs cohering parts, that they may more eafiiy yield ..their nourifliment to the dif- folving povvers of the ftomach. The more diligently they, are fubdivided in the mouth, the more reliihing and agreeable they become to the ftomach ; the nearer do they approach to the nature of a fluid, and the more eafily are they digefted or affimilated. §. 592. Therefore we are provided with a variety of teeth, extremely hard, but , planted w'ith a root that is indeed bony and hollow ; lince it receives, through a fmall hole in the tip or point of each fang, little blood-veffels, and a nerve, which go to form its internal pe- riofleum : and this whole root, being fix'ed into a focket of the jaw conformable to itfelf, is, in the upper part towards its crown, ftrongly furrounded and tied down by the adhering gums. But the crown,' or upper part of the tooth, placed above the gums,' is not bony, but a peculiar fort of enamel; of a harder denier fubftaitce, and almofl of a glafiiy texture, com- pofed of flraight fibres vertical with its root, and running together towards the middle. This Of Mcfication: 1 27 This lafl portion of the tooth, having neither' perlofleum norveflels, perpetually grinds away,’ and is as often repaired again by a kind of pe- trifying juice, that afcends or filters from the cells of the root, by which mechanifm they are, therefore, fupplied with a great degree of hardnefs, very fit to overcome that of other bodies, and to grind the food with their un- equal furfaces. §. 593. As the materials of our food are va- rious in their texture and firmnefs, nature has accordingly made our teeth varioufly figured. In us, the anterior or incifive teeth are four in each jaw, v/eaker than the reft, and fixed by a fingle root, upon v/hich ftands a crown inwardly concave, outwardly convex, and ter- minated by a gradual extenuation, like a wedge or chizel, with a redlilineal edge, the office of which, as their name imports, is only, in the fofter foods, to cut thofe which are tougher than the reft, into fmdier portions, fuch as the fibres and mem.brancs of animals and vegetables, with the brittle feeds and kernels of fruits. §• 594. Next to the former, come the ca- nine teeth, which are two only in each jaw, fixed by a longer and ftronger, but fingle root ; from whence their crown is extenuated into a cone. Thefe lacerate tough aliments, and hold faft fuch as grinders. §. 595. The third order of the teeth is, that of the molares, which, in general, are com- poled of feveral roots, wdth a quadrangular crown, fomewhat flat furfaced, but more or lefs require a longer triture by the 128 of MaJHcation. Icfs divided by rocky afperities. The two fore-i moiT; of thefe are weaker than the reft, in- ferred by two, or often but one root, with the furface of their crown parted into two j but the three pofterior grinders are larger, fixed by three, four, and fometirnes five roots, but ter- minated in their crown by only one furface, fomewhat fquare and flat, but lefs in the lower than upper jaw, and is fubdivided into a number of eminencies correfponding to that of their roots. Betwixt thefe teeth, the moft compad; or bony foods are interpofed and broke, as the more tough and hard are ground fmal- ler, while the lower teeth are urged obliquely and laterally againft the moveable upper ones ; and thefe are the teeth which perform prin- cipally what we are to exped from maftication of food. §. coo. That the teeth might break or grind the food with due ftrength and firmnefs, the uppermoft are fixed into the fockets of the im- moveable upper law, as the lower ones are into the lower moveable jaw, which is a Angle bone, and fo joined with the temporals, that it may be drawn down from the upper jaws, and pulled up againft them with a great force, and mav be moved laterally to the right or left, forward and backward. Thole various motions of the lower jaw depend upon the ar- ticulation of its oval heads, in which the lateral parts of the jiw terminate, convex or higheft in the middle, and received betwixt the ob- lique protuberances of the temporal bones, in a Ihallow excavation, at cheroot of the jugal pro- cels, Of Maficatiofi. 129 cefs, deeper in its middle, and increafed by a little excavation of the fame kind before the auditory paffage ; from which it is feparated by a peculiar fiffure. This joint has the freer li- berty in moving, and its incrufted cartilages have a longer duration, by the interpofition of a fmall cartilaginous plate, betwixt the condyle of the jaw and tubercle of the temporal bone, concave in its middle above and below, with rihng fides, which furround the tubercle of the temporal bone upward, the condyle of the jaw downward, and correfponds to the adjacent inequalities. §. 597. The mufcles moving the lower jaw, which are weaker in us than in brutes, are the temporalis and elevator, arifing from a large part of the fide of the Ikull, and from the out- ward tendinous expanfion of it, the ftellated fibres run together into a tendon, fixed to the coronal or (harp procefs of the jaw j the 7 naf- jeter and elevator, having two or three diftindt parts or lefs mufcles, ddcends from the os ju- galis and margin of the upper jaw backward into the angle of the lower jaw. Both the temporal mufcles, adting together, pull the lower jaw backward, as the mafieters do for- ward. The pterj-gcidcus internus defcends from the pterygoide foifa and from the palate bone and root of the hook, with the internal wing, into the angle of the lower jaw, which it ele- vates or draws to one fide or the other alter- nately. The pterygoideiis exiernus has a double origin ; one tranfverfe from the inner wing and adjacent bone of the palate, v/ith the pofterior VoL. II. K con- 1^6 Of Majlication. convexity of the upper jaw, the other, defcend- ing, arifes from the hollow temporal part of the great wing of the fphenoidesj thence it proceeds backward and downward into the outer part of the condyle of the lower jaw, which it moves laterally, and draws forward before the upper jaw. §. 598. The lower jaw is depreffed, fo as to open the mouth by the digraftic or biventer mufcle, arifing from an hollow of the maftoide procefs ; from whence defcending, its middle tendon is tied by a tendinous plate of the cel- lular fubftance to the os hyoides, and being likewife connected to the mylohyoideus, and then paffing through the divided fibres of the ftylohyoideus, it is increafed by another flefhy belly, inferted at the fymphyfis of the two halves of the lower jaw, within the chin. Moreover, the mouth may be partly opened by all the other lower mufcles of the jaw, os hyoides, and larynx, as the geriiohyoideus, genioglofius, fternohyoideus, fternothyroideus, coracohyoideus, and latiffimus colli j although the latter rather draws the Ikin of the neck and face downward than the jaw itfelf. §. 599. The lower jaw is elevated with a great force, fo as to divide the food by the prelTure of the upper and lower teeth againfl each other, by the action of the temporal, maffeter and external pterygoide mu cles ; the contradlion of which appears, by experiments, to be very powerful, fufficient to raife feveral hundred weight. The lateral and circular motions of the jaw, upon one of its condyles re- Of Majlication. 131 removed, are performed by the external and internal pterygoidei, adting either alone or to- gether with the former. §. 600. Thus the food is cut, lacerated, aid ground to pieces, and if the maftication be continued diligently, it is, together with the liquors of the mouth, reduced into a kind of pulp. For, during the trituration of the food, there is continually poured to it a large quan- tity of a watry clear liq :.or, evaporable or in- fipid, or, at lead, but little faune, and reple- nhhed with but little earth, in an healthy ftate, neither acid nor alcaiine, although from thence may be obtained a very imall portion of a lixival lalt j and this liquor flows under the denomination of lahva, from numberlefs fprings each way furrounding the food. A large quan- tity of this faiiva is feparated by numberlefs fmall glandules of the lips and cheeks, of an oval figure, which pour out their fecreted liquor through fhort dudts and oblique mouths. This liquor always abounds in the mouth, but in a greater quantity and fharper in thofe who are fafting; and, being naturally f wallowed with- out our notice, makes a moft uFful addition to the juice of the flomach itfelf j nor can this be lavifhly waited by fpltting, unlefs in phlegmatic perfons, without prejudice to the conflitution. The juice, poured out from the exhaling veifels of the tongue, mouth, and cheeks, is of the like kind, or rather more, watry. As for the duftus inciflvus, we are now fufficiently certain, that it is blind, or dif- charges nothing into the mouth, only gives K 2 paflage 1^2 ' Of MaJUcatio 7 i. paffage to an artery from that of the palate into the nares. §. 6oi. But there are other more confiderable falival glands, which fupply the watry humour called after their own name. Of thefe, the principal is the parotid, filling up a large inter- val betwixt the auditory paflage and the lower jaw, to which it is immediately contiguous in the part uncovered and to the mafleter j it is a conglomerate gland made up of round or grape- like clufters, connedted by the cellular fub- ftances ; which lafi;, being denfified and reticu- lated, forms an almofl; tendinous covering, that furrounds and connedls the whole gland. From this afcends a white, vafcular, capacious dudt, to the os jugale, from whence it is tranf- verfely inclined, and takes in, by the way, afmall dudl of a folitary glandule on the top of the malTeter, or elfe lodged difiindt, or continued upon the parotid itfelf, and is rarely double ; after this, the dudl, bending round the convex edge of the mafleter, opens with an oblique or cut aperture through the departing fibres of the buccinator mufcle, in the midfl; of many little glandules of the cheek, over-againfl: the root of the middle grinder. The bulk of this gland, and the number of its arteries, prove it to be the chief fpring, from whence the fa- liva flows. §. 602. Another fmall gland, adjacent to the parotid, but much lefs, compofed of fofrer and larger bunches, connected by the like cellular membrane, is, from its fituation at the lower angle of the jaw, called maxillary, being in Of Maftication. 133 part terminated only by the fkin, but in part fends off an appendix over the mylohyoide mufde, which, following the long hollow fide of the lower jaw, of a granular fabric, is fpread under the membrane of the mouth, by the name of fublingiialis. From the larger maxil- lary, together with this appendix, a dud pafl'es out, which, being a long way covered in its middle part by the fublingualis, receives one, two, or three branches, by whofe infertion it goes on, increaled to a cylindrical projecting orifice, under the bridle of the tongue. But there are ftiii other final! and fiiort duCts from the fublingual glands, from the number of three or four to twenty, which pour out a fa- liva through idiort little duds, or points, under each edge of the tongue. There are fome in- ftances where the larger anterior branch of the dud of the appendix, which ufually joins itfelf to the maxillary gland, goes on fingle, parallel, and opens by itfelf. Various other falival duds have been miftakenly publifiied by different profeffors, which are not confirmed by ana- tomy herfclf. §.603. The creator has wifely provided, that, by the motion of the jaw in malfication, the falival glands lhall be compreffed by mechani- cal neceffity, fo as to difeharge their juices then to the mouth in greater plenty. For vrhen the mouth is opened, the maxillary gland, being preffed by the digaftric and mylohyoideus, throws forth a fountain of faliva, as the parotid alfo does in the fame manner, when urged by jhe turgefcence of the mafleter j anddt is this K 3 V ' f'mufcu- ■o- f- 1 ^ 4 - Of MajUcatio]!. mufcular preffure, urging the faliva into the mouth, that excites the appetite or mouth-water. §. 604. The food, therefore, being in this manner giound betwixt the teeth, and inter- mixed with the i^aliva and air, into a foft juicy pulp, pliable into any figure, and replete with frothy or claftic air globules, does, by the adlioii cf the latter, undergo a farther diffolution, by the warmth ot the parts, exciting the elafticity of the air, to expand and hurft afunder the con- fining particles of the food, betwixt which it is included. In this act of mafticatlon, the oily, aqueous, ^nd faline parts of the food are inter- mixed the one with the other j the fmell and talte of d.fferent iijgredients are loft in ' ;e, which by the ddution of ihe faline pans w'ith faliva, renders the food favourable ; but fuch particies as are more volatile and penetrating, being directiy abforbed by the bibulous vefiels of the tongue and cheeks, enter ftraight into the bioon- vefiels and nerves, fo as to caufe an im- me'^iate recruit of the faculties. -§. 605. But the motions which are necelTary for turning round the food, applying it to the teeth, and conveying it through the different puts of the mouth in maftication, arc admi- nifired by the tongue, cheeks, and iips. And fi> if, the tongue being expanded fo as to form a Imali concavity in its back or furface, takes up the food thus prepared, and conveys the charge by the moving powers before deferibed (§. 4^51.) backward to the parts for which it is deligned. At one time the tongue rendered narrow by lateral contraction, iearches every Of Majilcat'ion. 135 part of the mouth with its tip, and turns out the latent food into a heap, on its common con- cavity. At another time, applying its extre- mity to the fore-teeth, and railing kfelf up fuc- ceflively, it draws the juices from the cavity of the mouth and together with the food, con- veys them to the fauces or back part of the mouth behind the teeth. §. 606. But thefe motions of the tongue are llkewife governed by the mufcles and mem- branes, largely inferred into the os hyoides, the balls of which is internally concave, from whence are extended horns laterally and out- wards, terminated by more protuberant heads, and completed with little oval cornidies j and this bone being drawn down by its refpedlive mufcles, deprelTes the tongue at the fame time, and the lower jaw likewife, if the mufcles of that be relaxed. Thefe depreffing powers are the JlernohyoideuSj but arifing alfo in part from the clavicle, extenuated upwards, and ftriped with tendinous lines ; the Jlernothyroideus arifing as the former, and broader from the upper rib, which mufcle depreffing the cartilage to which it is inferted, is under a neceffity of pulling down the os hyoides at the fame time ; this is partly intermixt with hyothyroideus, and in part confufed with the llernohyoideus. Next the coracohyoideus, arifing from the upper and Ihorter fide of the fcapula, near its notch, af- cends oliquely, and at the croffing the jugular vein, changes into a tendon, from whence the other belly of the mufcle afcends diredl to its infertion, into the os hyoides, which it deprelTes, K 4 being 136 Of Majlicafion. being in part confounded with the fternohyoi- deus. The hyothyroideus, a little inconfiderable mufcle, may be added to the former, by which it is determined. § 607. The other powers which elevate the os hyoides, together with the tongue, are its ftyloglodus mufcle, fuftained by a peculiar li- gament of the upper jaw. 2. The Jlylobyoi- deus, a weak mufcle, often fplit for the paffage of the biventer, and again united into one por- tion, after adhering to the tendinous expanfion of the biventer, is inferred, together with its fellow, into the angle of the bafis, and often into the horn of the os hyoides j the fecond rty- lohyoideus, when it is prefent, refembles the former, behind which it is placed, arifing from the tip of the ftyloide procefs, is inferted into the os triticeum, and anfwers the purpofe of a ligament to fuftain the os hyoides. Thefe alto- gether draw the tongue back, but laterally they elevate it. The mylohyoideus^ arifing from op- pofite fides of the chin, meet together in one, backward, ferving to elevate the tongue, and fix it in making various motions. The ge?2io- hyoideus being a companion of the geniogloffus, pulls the tongue forward out of the mouth. §. 608. But moreover, the mufcles of the cheeks varioufly move the food in the mouth, and by their prefihre on the outfide of the teeth, urge it into the inner cavity of the mouth, with- in the teeth, as we fee in the buccinators, when the mouth is fliut. Others again open the os externum, for receiving the food betwixt the cheeks and the teeth, fuch as the double head- ed Of Mafilcation. 137 ed proper elevator of the upper lip ; and the elevator, which is partly common ; to which add the zygomaticus, upper and lower ; the riforius, triangularis menti, and the depreffor, proper to the angle of the mouth, which ariling from an excavation on each fide, near the focket of the canine tooth, are iaferted into the orbicularis of the lips. Others again clofe the lips, that the food received may not return out of the mouth, fuch as the orbicularis of each lip, the proper depreffor of the upper lip, and the proper ele- vator of the lower lip, and that which ferves in common for the elevation of both. Of thefe more particular defcriptions may be had, from profefiTed fyftems of anatomy. §. 609. By thefe means the food, ground and mixed with the faliva into a foft pulp, col- ledled from all parts of the mouth by the tongue, into the arched fpace betwixt the teeth, is af- terward, by the expanfion and fucceflive pref- fure of the tongue, conveyed backward behind the teeth, and from thence thruft into the fau- ces j and in this adtion the tongue is expanded by the ceratogloffii, and geniogloffi, and ren- dered a little concave upon the ftyloglofius. LEG- LECTURE XXIII. Of Deglutition. §. 6 10. ^ jH ^ HE tongue being raifed by the ftylogloffi, and broadly applied to the palate, preiTes the food fuccefi'ively to- wards the fauces, which at that time only afford an open paffage. After this, the thick root and back part of the tongue itfelf, by the fore- mentioned mufcles, and by the ftylohyoidei and biventers carried backward, preffes down the epiglottis, which {lands up behind the tongue, connedled therewith by numerous membranes, and perhaps by fome mufcular fibres. At the fame time, the mufcles elevating the pharynx, all adl together, fuch as the bi- venter, geniohyoideus, geniogloffus, flvlohy- oideus, flylogloflus, flylopharyngeus, and the other elevators, which now draw the larynx up- ward and forward, that the epiglottis, being brought nearer to the convex root of the tongue, may be better clofed or depreffed. Hence it is necelTar}^ towards deglutition, for the jaws to be clofed, that by this means the biventer may have a firm fupportj and, together with the mufcles already deferibed (§. 607.) elevate the oshyoides. Thus the epiglottus being preffed down or inverted, fliuts up and covers the paf- fage very exadtly, into the larynx, over which it is extended like a bridge, for the aliment to pafs over into the fauces. 61 1. Of Deglutition. 13-9 §.611. By the pharynx we underfland an ample cavity, fomewhat like a membranous funnel, multiform, with a deficiency before, ex- tended from the occipital bone before the great opening of the fkull downward, along the bo- dies of the cervical vertebrae, covered above by the middle cuneiform bone, the opening of the nares, and moveable velum of the palate, re- ceiving the tongue and larynx before, and the osfophagus below, fo as to form onefoft mem-, branous bag, outwardly furrounded on all fides by mufcular fibres, internally lined with an epi- thelium, or continuation of the cuticle, like which it is renewable, but more moill; ; out- wardly it is furrounded with a good deal of cel- lular fubftance, more efpccially in its poflerior and lateral parts. By this ftrudlure it becomes lax and dilatable, fo as to receive all bodies that are preffed by the tongue over the larynx. §, 612. This mufcular bag is dilated in its adhon (§.610.) by the powers ferving to its elevation, fuch as the Jiylopharyngeus^ fome- times double, from the procefs of its name ; whence defcending, it is inferred into the mem- brane of the larynx, under the os hyoides, and into the cartilaginous edge of the defcending thyroideus, after which it is broadly fpread through the internal face of the pharynx, toge- ther with the following. The thyropahtinusy or flap' ylopharyngeus being fpread in the form of an arch round the moveable palate, and from thence extended downwards in two columns, on each fide the pharynx, form a confiderable part of that bag, being alfo connedied by broad hbres 140 Of 'Deglutition. fibres to the thyroid cartilage. That the faU pingopharyngeus is a true or diftind; mufcle, I am ready to believe, rather from the obferva- tion of other eminent anatomifts, than any of my own. As to the ctphalopkcryngem^ I almofl defpair of finding any, un'lefs yon will reckon the ftrong white plate of the cellular fubfiance, which furrounds the upper part of the pharynx for a mufcle. This bag clofely furrounds and follows the drink, on each fide the epiglottis, above the larynx j and from thence it falls into the cefophagus. §. 613. That the aliments might not regur- gitate into the noftrils, at the time when they are prefl'ed into the dilated pharynx (§. 612.) a moveable velum or palate is interpofed : name- ly, fiom the fides of the bony palate and prerv- goi e wings, is contained a moveable expa.if ■ compounded of the membranes fr ^n th. mi ur;i and nares, betwixt wh:ch membranes wi werd mufcles ; being almoft of a fquare fig’-^'" and pendulous, betwixt the cavity of ti^e nares and fauces, in fuch a manner, that they natn rally leave the former open, and form a concave arch towards the mouth ; and from the middle of this is extended a fmall portion, pendulous, and of a conical fihape, before the epiglottis, re- plete with many fmall glands, which from its appearance in a difeafed flate. is called uvula. The elevator of this velum, which is ftrong, arifes from the afperities of the cuneiform bone, behind the fpinal foramen ; and from a carti- lage of the tube defeending inward, does with its companion, form an arch, which is move- able Of Deglutition, 14 k able with the palate itfelf, fo as to be brought into a clofe contact with the fides of the nares, and with the tubes, that none of the aliment may enter into either of them. But this elevator does not feem to have any confiderable adtion in fwallowing ; at which time regurgitation into the noftrils is prevented by a conftridtion of the mufcles of the pharynx, together with a depref- fure of the thyropalatini, which then manifeftly draw the moveable velum downward, and to- w'ards the tongue and pharynx. [Add to thefe the circiimflcxus palati moiln^ which arifes a little more forward from the fame cuneiform bone, from the internal fide of its wings, and from the inner wing, with the cartilaginous end of the tube, broad, and then paffing through a notch, of the pterygoide hook, changes its di- redtion, and afcends with a radiated tendon, through the upper membrane that covers the velum of the palate, joins with its fellow, fpreads over the other mufcles, and adheres to the edge of the palate bone. This is able both to open the tube, and to prefs down the moveable velum of the palate, j So as to make a preffure upon the contents ; and from hence the pha- rynx being contradted like a fphindter, drives down the food, without permitting any part to return back into the cavity of the nares. Hence we fee, that when the immovable velum of the palate is perforated, or otherwife vitiated by dif- eafe, the aliments regurgitate into the noftrils, and flop up the Euflachian tubes, fo as to caufe a deafnefs. §• 614. 14^ Of Deglutition. §, 614. During this endeavour to deprefs the food by the pharynx, (§. 614.) the velum drawn back and expanded over, is pulled down to- wards the tongue, by the adion of the palato- pharyngei, and by the circumflex mufcles of the foft palate, (§.61:?.). Thefe mufcles, to- gether with the glolTapalatini, which lafl; are indeed weak, prefs the velum againfl; the pro- tuberant root of the tongue, and intercept anv return to the mouth. After there is no farther danger of any part falling into the wind-pipe, the epiglottis is raifed up again, as well by its own eiafticity, as by the elevation of the tongue itfelf, by which it is drawn forward. [Laflly, the deprefled uvula is raifed by the azygos, which arifes from the tendons of the circumflexi mufcles ] §. 615. Immediately after this, follows a force urging the food downward, which is ex- erted by the conftridor mufcles of the pharynx, drawing the fore and back parts together, and the mufcles which are partly tranfverfe, and partly afcend into the poflerior furface of the pharynx. Of thefe the principal is, the ptery- gopharyngeus, ariflng from the whole hook and internal edge of the wing j from whence form- ing an arch, it is extended upward and back- ward, largely furrounding the upper part of the pharynx. The mylopharyngeus, partly continuous with the fibres of the buccinator in the middle, betwixt an infertion or adhefion to the bones, arife alfo in part from an origin of their own, above the lafl: of the grinding teeth, in the lower jaw. Thefe having a courfe al- raofl Of Deglutition, 143 moft tranfverfe, furround the pharynx, and draw its back towards the forepart. Next to thefe follow the geniopharyngei, afcending in two ftrata of obfcure and confufed fibres j next the chondropharyngei, of a triangular figure, arifing from the oflicula triticea j the cerato- pharyngei, which afcend radiated from half of the horn ; the fyndelmopharyngei, arifing from the horn of the thyroide cartilage, and diftind: from the former ; to which add the thyropha- ryngei of both kinds, increafed by the fibres of the fiernothyroideus and cricothyroideus, with the cricopharyngei, the tranfverfe, afcending and defcending. Thefe mufcles adting fuccef- fively from above downward, according to their fituation, drive the aliment into the eefophagus: at the fame time the depreffing mufcles of the larynx, coracohyoideus, fternohyoideus, and fter- nothyreoideus, draw down the larynx forward, and lefiening the capacity of the pharynx, urge the food downward. But in this ad:ion, as the aliment pafies by the pofterior rima, or opening of the glottis, the aryarytcenoidei contrad the larynx perpendicularly together. §. 616. As various dry and rough bodies are frequently fwallowed, it was necefiary for the pharynx to be dilatable, and not fo fubjed to pain as the tongue, fiomach, and fome other organs; to which end like wife, the great quan- tity of mucus, which is collected in all parts of the fauces, greatly conduces. Therefore, in general, betwixt the nervous and limermoft coat of the pharynx, are placed a great numoer of fimple mucous Jtoliicles or ceils, oi ai' '/al figure. 144 figure, pouring out their mucus through fhort mouths, of a foft vifcid, and fomewhat watery nature, but ropy or drawing out into threads, whence it abounds more with faline and oily parts, than the faliva itfelf. Thefe mucous re- ceptacles are moft plentiful in that part of the pharynx, which is immediately extended under the occipital bone, where they are difpofed in a fort of radiated right lines j and they are like- wife numerous in that portion of the pharynx, which is called falpingopharyngeus. But there are likewife other flat and circular follicles, feated in great numbers about the back part of the tongue, as far as its foramen caecum (§. 448.) into which, frequently, when it forms a long finus, there are many mucous follicles open, together in common. Other follicles and pores of the fame kind are every where feated in the pulpy flefli of the palate, where numerous fmall glands difcharge fuch a vifcid mucus. More- over, the whole furface of the moveable palate, is of a glandular nature, like that of the pha- rynx, only the follicles and glandular corpufcles, are here more numerous and thickly fet to- gether O §. 617. Where the pharynx defcends late- rally from the hook of the bony palate, betwixt the portions of the glolfapalatinus, and pha- ringo-palatinus, are feated the tonfils, of an oval figure, perforated inward with ten or more large finufes, which open through the membranous covering of the velum extended over them, and by the preflTure of the adjacent mulcles, ferve to difcharge a great quantity of a moft 4 thick Of Deglutition. 145 thick mucus from their finufes. In like man- ner, the adjacent parts of the nares, and pro- jedting rings of the tubes, in that hde of the epiglottis that lies next to the larynx and the back of the arytcenoide cartilages, are alfo re- plenithed v/ith mucous organs. Laftly, the oefonhagus itfelf on all fides abounds with fimple follicles, from whence a mucus is poured out fomewhat more fluid. But the larger glandulae cefophagaese are of the conglobate, or lymphatic kind, and conduce nothing to this mucus. The blood-veffels of the ton fils, are fupplied from thofe of the tongue, lips, and pharynx itfelf ; as thofe of the oefophagus are derived from the branches of the pharynx, upper and lower thyroidals, from the bronchials, and lower, from the aorta itfelf. The veins of the palate and tonfils being numerous; run together into a net- work, ending in the fuperficial branch of the internal jugular. §. 618, The oefophagus, then, is a double tube, of which the innermoft is feparated from the outer, by a good deal of cellular fiibftance, that may be inflated. The innermoft tube of the cefo- phagus, is nervous and flrong ; being continued from the membranes of the mouth and nares, on its inner fide villous, or like fine velvet, but fmoother; not fleecy, but of a pulpy confiftence, having this innermofl lining diftinguifhed from the red, by a thin cellular fubflance, in which the fmall veffels. are reticulated with minute glandules interfpcrfed. The outer tube is muf- . cular,'and in itfelf confiderably flrong, com- pofed of fibres internally continued from the VoL, II. L lower 146 Of Deglutition. lower and back part of the cricoide cartilage, which by degrees change from annular to fibres, that are externally longitudinal, and ferve to draw up and dilate the cefophagus, againft the food, for its reception. But the other internal circular fibres, which are ftronger than the for- mer, arife in like manner from the top of the cricoide cartilage, and by their luccellive con- traction againft the food, drive it down through the whole long tube of the mfophagus, which defcends firft in a diredt courfe, a little to the left fide of the wind-pipe j but having reached the cavity of the breaft, it paftes behind the heart, through the cellular interval, that lies betwixt the bag of each pleura (§. 75.) j from whence inclining by degrees, a little to the right, it afterwards bends again to the left, to its pro- per opening, by which its included food paftes tlirough the diaphragm (§. 289 ) in the inter- val of time that is betwixt expiration and infpi- ration: but outwardly, the whole tube of the cefo- phagus is furrounded by the cellular fubftance. §. 619. This upper opening of the ftomach, is contracted or comprefted in fuch a manner, by the lower mufcle of the diaphragm, in every infpiration, as to confine the food wdthin the Itomach, and diredt it in every refpiration, by preffure, naturally tow'ards the pylorus. By this means, the upper, or pofterior orifice of the fto- mach, is fo clofely ftiut, as to confine even wind or vapours within the capacity of the moft healthy ftomach, from whence they never el- cape, but by a morbid affedtion. L E C- 147 LECTURE XXIV. Of the Stomachy eind its Adllon on the Food. §. 620. Y the ftomach, we underfland a J3 inembranoas vellei, or bag of a peculiar figure, dellined for the reception and further diflblution of the food, within the cavity of the abdomen, behind the left falfe rib?, in ge- neral of an oval figure, and like a cafk, of a lon- ger diameter tranfverfely than perpendicularly; and this more fo, as the perfon is more adult; but in the foetus it is altogether flaort and round. But if we confider more accurately, every fed;i- on of its figure, they will appear circular ; al- though there be a blind or obtufe concavity in its left extremity, from whence it grows wider towards the cefophagus, at vvhofe infertion its light or fedlion is the iargeft of all, diminifliing by degrees thence forward and to the right lide, wliere it terminates, by forming a fliort bend in a contrary diredfion to itfelf, called the pylorus. Th.us its fituation, in general, appears to be tranf- verfe, yet fo that the cefophagus enters its pofle- rior fde, and the pylorus goes out from it for- ward to the rio-ht fide. The middle of the bo- dy and enfiform cartilage, thus cover or anfwer to nearly the center of the ftomach. Since its figure is oval, but incurvated, its lower convex- ity will form a larger pendulous arch wdien empty; but when full, the middle convexity of the laid arch will be raifed outward to the con- L 2 tact 148 Sumach and T)igcjllon. ta6l of the peritoneum, defcending before it : on the other hand, the leffer arch, intercepted betwixt the two orifices, will, in this ftate of the fcomach lie periedlly backward towards the fpine, fo as to include the fmall lobe of the li- ver. Thus the infertion of the cefophagus into the full flomach, will be in an obtufe angle, in a manner parallel with the horizon ; but in the empty flomach it will be alrnoft perpendi- cular ; and at the fame time, the right extre- mity of the flomach forming the pylorus, which in an empty ftate, lies bent upward, will, in the full flomach, he hent more backward, fo as to defcend in perfons lying on their back. § 621. About the ftomach are placed the coadjutant vifcera ; and particularly to its large imperforated extremity, is connedled the fpleen, by a confiderable portion of the omentum ; the leffer a.rch or curvature of the ftomach receiving the little lobe of Spigelius, has likevvife the lelt lobe of the liver, largely interpofing betwixt the ftomach and the diaphragm, which lobe partly compreffes the ftomach forward, below the margin of which a portion of the ftomach lies immediately contiguous to the diaphragm itfelf, yet fo as, by a moderate exteniion, to lie hid within the bounds of the falfe ribs : under and behind the ftomach, lies the pancreas, ex- tended for a confiderable length in an empty fpace, upon the tranfverfe portion or the colon : aTaiin from the Idler curvature or arch, ari.es tne little omeiitum, to which is continued the ftronger membrane, that conneds the cefopha- gus with the diaphragm j nor is the large omen- tum ^be Stomach and D 'gpjUon. 149 turn connected to the whole length of the fto- mach, but leaving a deficiency to the right fide near the pylorus, it is continued on beyond the left extremity, into a ligament, which connedls the ftomach and foleen together. The liea- ments, in thefe parts, are produdlions of the pe- ritoneum, which receding from the diaphragm, foreads itfelf over the ftomach, fo as to form its outermofi: coat. §. 622. The fabric of the ftomach anfwers in general to that of the cefophagus, of which it is an expanfion, and in fome animals has in all its parts the fame mu fcular appearance. ( i.) The outermoft coat is from the peritoneum, of con- fiderable ftrength, fo as to confine or limit the extenfion of the reft, and afford a fupport to the fubjacent mufcular fibres : this is expanded into the little and great omentum, after leaving the ftomach. (2.) The cellular coat lies immedi- ately under the former, more abundant in the origin of the little omentum, where it contains little conglobate or lymphatic glandules, vehich alfo holds true of the cellular fubftance in the great omentum ; but it is thinner and much lefs con- fiderable betwixt the coats of the ftomach itfelf, whence the outer and mufcular tunic clofely cohere together : in this fubftance the larger branches of the veftels are diftributed. §.623. Next in order, appears 1 3 . ) the mufcular coat, neither eafy to defcribe or prepare. Here, indeed, we fee the longitudinal fibres of the oefo- phagus, coming to the ftomach, are detached one from another in all direftions or points from the cardia 3 fome of them of more confiderable L 3 ftrength. 1^0 T’l-C Stomach and TjigeJl'.on. ftrength, run on to the pylorus, along the lelTt^r curvature, which by degrees declining frcm their longitudinal courfe, defcend or fpread into a plain of each fide, and are in part flretched out through the pylorus itfelf, into the duode- num, where they gradually difappear. Other fibres, in like manner, of a thinner kind, def- cend to the great obtufe extremity of the fto- mach, Vv^hich has no opening, feated on the left fide : and finally, through every fedVion of the flomach, from its blind or left extremity, to the pylorus, are fpread concentric circular fibres, which by degrees increafng in their thicknefs or number, are continued on with the refl of the circular fibres belongintr to the flomach : ‘this lafi makes the moft confiderable order of the mufcular fibres. But the fphindter of the cardia and oefophagus, is compofed internally of fibres, arifing from the left fide of the dia- phragmatic aperture, and running to the right, pafs on each fide thegula, which they thus clofely , embrace, and then degenerate longitudinally, till they are loft under the circular or fecond flratum, near the pvlorus. But the ligaments of the pylorus are two membranous detachments, betwixt the two incurvations into which the pylorus is bent, formed by the forefaid longi- tudinal fibres, which run alons: frcm the fto- mach to the pylorus, and are very clofely joined to the internal coat, in their way. §. ( 24. Immediately under the mufcular ffores, follows (4.) another cellular flratum, larger than the outermofl, fofter, more ealily infi.itaWe, and confiiling of larger cells or vclicles than what 7 'he Stomach and 'DigeJUon. 1 5 1 what we ufually obferve, even in the inteftines. Within this cellular fubftance are fpread the fmall veflels, which, coming from the larger branches of the ftomach, enter through itsmuf- cular coat, and fpread internally, by an angular fubdivifion, after the manner of a plexus. Un- der this lies ( 5.) the nervous coat, which is thick, white, and firm, and properly makes up the true nature or fubftance of the flomach itfelf, after the manner of other nervous parts : and this is again lined internally with a third cellu- lar ftratum, evidently enough to be perceived, whofe vafcular net-work is much more minute than that of the former, from whence it is de- rived. Immediately within this, lies (6.) the vil- lous or velvet-like coat, that lines the cavity of the ffomach itfelf, continuous with the external cu- ticle, like which it is renewable, but of a fofc mucous texture, and extended into a very fhort pile, like that of the tongue, only lefs confpi- cuous, and folded into large pleates, which form a flar under the cefophagus j but in the middle of the ftomach, thcfe folds are> almofl parallel with the fiomach itfelf. But, at the extremity of the pylorus, there is a more confiderable fold, commonly called valvula pylori, which is formed by a production both of the traniverfe mufcular hbres, and of the thicker nervous coat, extended together in the fhape of an un- equal loofe ring, floating towards the duode- num ; this forms a flippery flefhy protuberance, which lurrounds the duodenum for a confider- ab.le length. The large wrinkles of the villous membrane are afterwards fubdivided more mi- h 4 nutely 152 The Siomach and Digejiion. nutely, into others of'a quadrangular or net-like figure j but very (hallow, and eafily difappearing, being much more obfcure than thofe in the biliary dudts. Within this villous coat of the ftomach throughout, but more efpecially to- wards the pylorus, I have truly obfervedfome pores, not always to be perceived, which ter- minate in (imple follicles, feated in the next cellular ftratum. §. 625. The vefTels of the ftomach are both numerous and derived from many trunks or va- rious quarters, that the courfe of the blood through them might not be intercepted by any kind of preffure, as it might eafily have been, if the veffels of the ftomach had come from a finale trunk. The common mother of all thefe gaftric arteries is the coeliac, from the three-fold divifion of which, or above the faid divifion, arifes the upper coronary, which is the firft and largeft artery that palTes in a (ingle branch round the edge of the oefophagus into the ftomach j to which firft, and afterwards to the diaphragm and to the liver, it fends off home ra- mifications, and then running on the le(Ter arch or curve of the (tomach, it inofculates by more than one branch vrith the le(Ter coronary of the right fide, arifing from the right branch of the cceliac at the vena portarum., and is difiributed along the le(fer curve of the ftomach. But the fame right branch of the cceliac, after it has defcended behind, at the beginning of the duo- denal, gives off a very confiderable artery that runs along the great arch or curve of the fio- mach, where, being cloathed with the origin of ^he Stomach and Digeflion. 153 of the omentum, it fpreads itfelf both upon each fide of the ftomach and upon the greater part of the omentum itfelf, being, at laft, in- ferted by inofculation into the left gaftro-epi- ploica. Namely, the left coeliac trunk, paf- £ng along in the diredion of the pancreas and hnuofity of the fpleen, there fends off m.any fmall arteries of various fizes to the ftomach ; of which the firft are commonly namelefs, and among the following, one branch, more condderable than the reff, is called the left gaifro-epiploica, which fends off a confider- ahle twiff to the omentum, with fome others that are fmaller ; from whence, defcending round the ftomach towards the right fide, it inosculates vrith the right artery of the fame name. Other fmaller arterial circle-, coming from thofe of the fpleen, are fpread upon the greater curve of the ftomach, even as far as the diaphragm, under the denomination of the vafa brevia. The other fmaller arteries are the upper ones of the pylorus from the hepatics, and the lower ones from the gaftro-epipioics ; but thofe of the lower part of the oefophagus, are from the phrenic arteries. § 626. Thofe arteries are diftributed in fuch a manner, that firft they fend off very fhort twigs to the external and to themufcular mem- branes of the ftomach, as they pafs through the firft cellular ftratum, with which their trunks are furrounded ; from whence, dimi- nifliing in fize, they penetrate through the muf- cular coat, and within the cellular ftratum, be- twixt that and the nervous, they compofe a larger and 1 54 oiomach and D'gejlicn. and truer net-work ; in which all the fmall ar- teries, coming from a great variety of trunks, join one with another, by an infinity of inofcu- lations. From this plexus again, other fhort, but numerous and very fmall ramifications, pafs through the nervous coat to the third or inner cellular firatum, and are lold in the villous lining of the ftomach. §. 627. The veins have their branches di- flributed, in company with the correfponding arteries. The greater coronary from the left fide of the fcomach generally goes to the trunk of the porta, together with the brevia and left gaftro-epiploic j while the right vein of the iaft denomination joins with the middle vena colica, and, together with a branch from the me- fentery, pours its contents into the vena por- tarum. Finally, the right coronary vein be- longs to the trunk of the vena portarum itfelf. All thefe veins are without valves ; and like the arteries, there are upper coronary veins, vritii others of the oefophagus from the thorax, all communicating together by inofculations, in fuch a manner, that there is a free pafiage fur the blood thence into the vena azygos, with which they inofculate. «/ 62H. The nerves of the ficmach are both large and numerous, produced from the eighth pair, forming two complications about the celo- phagus, of which the anterior and lefs plexus defcends through the upper or outer fide ot the fiomach to its greater curve ; and the pofierior plexus, which is larger, is diilributcd through the lefier arch of the ftomach ; from whence it pafies, together with the arteries, to the liver, pancreas. T^he Stomach and Digefti-n. i pancreas, and diaphragm itfelf. Thefe nerves mav be traced into the fecond cellular ftratum of the ftomach, that furrounds its nervous tunic ; in which, but more efpeciaily in the papillae, they become obfcure or lod. From their number, the ftomach is extremely fen- fible, infomuch, that things, which make no impreffion upon the tongue., will naufeate and pervert this organ, wd.iich is capable of much feverer pain thaa the intellines ; as we know from infallible experience in difeafes : even the fldn itfelf, when naked by a blider, s lefs fen- fible tlian the ftomach. By making a liga- ture upon the nerves of the eiglith pair, both the adfion of the ftomach and the digeftion of the food ceafe. § 629. Lymphatic velfe's I have obferved, fometimes very confiderable, about the leh'er curve of the ftomach, ariftng from the glan- dules of that part, and inferred by a very large trunk into the thoracic dudt. Others, no doubt, arife from fmall glandules of the fame kind in the greater curve. That there are other ladteal veflels more than thefe in the ftomach, I have never been able to fee, nor am ready to believej particularly thofe lately defcribed, and faid to pafs from the ftomach through the omientum to the liver, filled with a true chyle. §. 630, Vvithin the human ftomach, we hrft meet w/ith a great quantity of mucus, fpread upon its villous lining, from the pores before de- fcribed (§. 624..), which mucus is not unfre- quently tinged, by fome of the bile returning into the ftomach. Beftdes this, in an empty ftomach 1 56 T/ 5 /f Stomach and Digejlicn. ftomach, after faftinjT, upon bending the body, a great quan ity of a limpid or watry humour will arife into the mouth, altogether of tlie fame nature with the faliva ; which liquor is very rarely to be found pure or unmixed in the flomach ; for if ir can be fo had, free from any mixture of the food, it is very far from pofieffing any acid or alcaline acrimony ;• but, on the contrary, if it be free from any acid or acefcent relicks of the food, it fpontaneoufly changes both in man and brutes, rather to a lixivial or alcaline na- ture. This liquor diilils from the arteries of the ftomach, through its villous coat, after the manner we fee by anatomical injections ; by which water, h/Ii-glue, and oil, may be eafily urged into the vefTels of the ftomach, fo as to fweat through its numbcrlefs pores. §.631. The ftomach then, contained with- in the abdomen, which is perfectly full, will, from thence, as in a prefs, receive a force or cornpreffure upon its tides, which lie betwixt the diaphragm ; the concavity of vvhofe right wring is filled by the liver, under which, and •within the left wing, lies the ftomach, extend- ed almoft tranfverfely behind the relifcing muf- cles of the abdomen, viz. the reCti and obliqui. The iT.ore the ftomach is filled, the more it is urged by this prefiare of the abdcmdnal muf- cles, becaufe,at the fame time, it rifes upward, in a right angle, to the contaCt of the peri- toneum. §. 632. Into the capacity of the ftomach are conveyed .f jods, often crude or in a tough ftafe, and but iicf.e altered by the teeth ; and theie ^he Stonwch and DigePdon. often, in a variety of kinds or mixtures, feme of them being alcakfeent, as flefn meats j rancefeent, as oily or fat fubfances ; or acefeent, as bread, milk, and moft of the vegetable kind. Thefe, we obferve, are digefed in an heat equal to that of an hatching egg, adminifred to the ibomach by the contiguous fpleen, liver, and fuperincumbent heart 3 and this in a cavity al- together dofe or confined above, as we have feen (§. 619.), as it alfo is below, by the afeent of the incurvated pylorus, and, in a great mea- fure, by a (hutting valve, and likewife con- ftringed by a miufeuiar force of the fibres; from whence we obferve, 'that even milk itfelf is often retained in the ftomach of flrong animals feveral hours after a meal. Obferve again, that thefe aliments are continually cohobated or moiftened with watry iuices, and, at the fame time, are replenifiied with a good deal of air incorporated with them, either naturally cr in the mafiication. This air, therefore, expand- ing by the force of heat, putrefadlion, or fer- mentation, breaks open the cells by which it was included, divides the vifeid liquors, and foftens or opens the folid fibres, fo as to make a way for difeharging their juices. But the fame fubfiance of the air, turning to a folid, makes the principal glue or cement, by which the animal lolids and other bodies receive their firmriefs ; and this, being extricated b}^ heat, leaves the other elementary parts friable or without a vin- culum, as we fee from the change of bony fub- flances in Papin’s digeiber, in the ffcmachs of many animals, and even in that of ourfelves. This I FJcmach and Digeflion. This air, fct at liberty by the digeftion, often diftends the llomach more than the food itfelf, under the denomination oF Vv-ind or flatus. \¥hi!e this air is extricated, the aliments by long day begin to corrupt or change into a nau- feous liquid, either acid, mucous, putrid or rancid, which two lad happen lefs in mankind, from onr ufe of bread, fait, wine, &c. For the truth of which, we may appeal to the flatus and matters erudfated, often of a mod foetid, caudic, and inflammable nature, from fub- dances of the like difpofition. T his putrefcency, or imperfedt putrefadlicn, is almod the only caufe of digedion in fidi, lerpents, and car- nivorous birds. Even in mankind, we fee, that metals themfelves are, from thefe caufes, eroded and didblved. At this time hunger is abfent, the nervous pleates of the domach being removed and defended from their contadts with each other by the interpofed aliment, at the fame time that the juice of the domach itfelf is lefs fharo, and freer from a mixture with the old remains of the lad food, which often ex- cite a naufeating uneailnefs in the nerves of the domach. §. 633. But that the aliment might not de- generate into a complete corruption or acri- mony, for the mod part of t!ie acid kind, there is a check from the putrefcent degree of t!ie heat, the quantity of juices didilhng from the domach, and that of the faliva itfelf fwal- lowed to the amount of half an our.ce in an hour, and rather inclined to an alcalefcency ; alfo thefe* juices, being ground together with 2 • tie ^he Stomdch and D/ge/Uon. 159 the aliment, macerate, Toften, and diffolve the fibres themfelves and their cellular bands, leaving them a foft pulp, like what we fee, by- letting them ftand for a long time in warm water. There is, therefore, no particular kind of ferment in the flomach ; from which the de- fign of nature, the difpolition of the llo- mach, and its ufe, are all very remote, §. 634. The flefliy fibres in the ftomach, being now irritated by the flatus, weight, and acrimony of the food, begin to contradl them- feives more pow-erfully than when the flomach is empty, and with a greater force, in proportion, as it is more full ; becaufe the round diflention fcrves the fibres as an hypomoclion or point for motion. And firfl:, the rnufcular flratum, which pafTes along the leffer curvature, con- nedts the pylorus with the cefophagus, and, being inferred only into the left face of the former, draws it to the right. The principal ftratum of the circular fibres ccntradfs the ca- pacity of the ftomach, according to its length, erinds or intermixes its contents, toy;ether with the liquors (§. 630.), and determdnesthem both, like the preffure of fo many fingers, to flow towards the pylorus : but this flux through the pylorus is not made continually, for reafons before affigned (§.624.), as well as becaufe this motion begins from fome part that is more irritated ; and from thence the aliment is driven here upward, as in other parts downward. In this adtion of the ftomach, there is nothing which refembles the triture made by the ftrong gizards of granivorous fowls, wdiich fome ana- tomills i6a T’he Stomach mid Digejlion. tomifts have afcribed to the human flomach ; which yet has a con liderable degree of ftrength, fince the contradiion of its fibres is often more than a third part of their length ; for vve fre- quently fee the ftomach reduced to lefs than a third of its diameter, even to the quantity of a few ounces, with a collapfion of its fides. §. 63 c,. But the ftronger periilaltic motion of the flomach, is that which it receives from the diaphragm and mufcles of the abdo- men ; for, by the preffure of thefe, the ffo- mach is more perfedlly emptied by a clofe ap- proximation of its anterior and pofferior fides. ^ For it is principally by this force, that the drinks are urged on continually, but the foods only when they are diffolved, left thofe parts, which are too grofs, fliould be expelled through the pylorus into the duodenum, when the ho- mach is more that way inclined by repletion ; for the folid aliments do not feem to leave the ftom.ach, before thev have changed their fibrous or other texture for that of a grey mucus, dif- folving into a yellowifh and foiTiewhat foetid pulp, like a liquid. That which is frlf pre- pared and turned fluid, goes before the reft out of the ftomach j firft water, then milk, pot- herbs, bread, and laft of all, fleili meats, the harder, tougher, and longer fkins or fibres of which pafs unchanged ; but fuch things or bodies, as are hard, or too large to pafs the pylorus, are retained in the ftomach for a long time. §. 636. But a conftJerable portion of the drink . is abforbtd by the inhaling veins of the The Stomach and Digeftion. 1 6 1 flomach itfelf, which open in the pendulous villi, and exert a force like that of capillary tubes or lyphons, and are correfponding to the exhaling arteries of the fame part (§. 630.) ; fo their contents take a more immediate or (hort way into the blood, as plainly appears from re- peated experiments of injeding the veins. Whether any part may pafs into the lymphatic veffels (§. 629.), is doubtful. §. 637. The ftomach, being irritated by too great a quantity or acrimony of the food, or elfe by ficknefs, a repulfion of the bile, or other caufe, does, by an antiperidaltic or reverted motion of its fibres, drive its contents upward, through the open and relaxed cefophagus, in the act of vomiting. But then this eftecl is partly from the prefiure of the abdominal mufcles, depreffing the falfe ribs, and urging the contents of the abdomen againfii the dia- phragm, which, at the fame time, contrading itfelf to a plain downwards, forces the fiomach, in a manner, as betwixt the fides of a prefs, to throw up its contents. §. 63*^. But the aliments, drove in their na- tural courfe through the pylorus to the duode- num, meet there with the influent bile and pancreatic juice, which often flow back into the flomach. But the former of thefe, being the principal bafis of chylification, will require from us a previous hiftory of the vifeera, which convey their blood, through the vena porta, for the fecretion or formation of the bile, before we can proceed to enquire into the nature and effeds of that powerful humour. ' . Vul.il m leg- i 62 LECTURE XXV. Of the Omentum^ §. 639. Y the denomination of ferito^ _|]3 nceum^ we underftand a ftrong fimple membrane, by which all the vifcera of the abdomen are furrounded, and, In a mea- fure, fuftained. Internally, towards what is called the cavity of the abdomen (but naturally always full) this membrane is fmoothly furfaced and moiftened with exhaling vapours ; but outwardly it adheres to all the parts by the loofe cellular fubftance, which towards the kid- neys contains a good deal of fat, but It is ex- tremely thin and Ihort before, betwixt the pe- ritonreum and tendons of the tranfverfe mufcles of the abdomen. The peritonaeum begins from the lower fide of the diaphragm, which it lines, and in certain intervals, joining with the cor- rcfponding pleura above, it compleats what W’ould be otherwile deficiencies in the dia- phragm, as betwixt the ultimate flefliy fibres next the ribs and at the loins ; to which add its continuations upward, through the foramina of the diaphragm. From thence this mem- brane defcends, in its fore-part, behind the ab- dominal mulcles ; in its back-part, before the kidneys ; and going into the pelvis, from the bones of the pubes, it pafies over the bladder ob- liquely backward, and then re-afcends back again over the ureters by two lunar folds or plates, Of the Omentum. l6j plates, rejoining upon the inteftinum redlum with the former part of itfelf, which inverted the loins, and in the fame place, goes next before the reftum. §.640. But through this general extent, it fends out various productions or reduplications, fof covering the vifcera. The fhorter productions of this membrane are, in feveral of the vifcera, called ligaments ; and are all of them formed by a continuous reduplication of the peritonaeunl, joining their outer furface, together with a cellu- lar fubftance, interpofed and extending to fome one or other of its vifcera, where its plates fe- parate again from each other to embrace the organ, which they are to furround and furnrrti with a coat but the cellular fubftance always intervenes betwixt this membranous coat of the peritonaeum j fo that it may be eaiily di- rtinguifhed, and, in moft parts, feparated from the true fubftance of the organ itfelf. Of pro^ duCtions of this kind there are three ftiort ones belonging to the liver, one or two to the fpleen, and others to the kidneys, lateral parts of the uterus, &c. By this means the tender fubftance of the vifcera is defended from injury by any motion or concuffion, and their whole mafs is prevented from being mifplaced by their own weight, as they receive a fure connexion to the firm fides of the peritonaeum. §. 641. But the moft ample and moveable of all thefe productions from the peritonaeum are, thofe called the mefentery and mefocolon j the defcription of both which, although diffi- cult in words, ought not to be feparated from M 2 that 164 ihe Omentum. that of the peritonaeum itfelf. We fhall, there- fore, begin firft with a defcription of ihtmefo- colon^ as being the more fimple. In the pel- vis, the peritoneum fpreads itfelf within a fhort compafs, and afcends before the redum ; but where that intefllne bends into a femilunar curve, the peritoneum there departs out far from the iliac veffels, which lie upon the mufcles of the loins, and arifes as if duplicated (§. 640.), fpreading itfelf in fuch a form, as is fitteft to receive the colon into its capacity. But above, on the left fide, that the colon might be at liberty, ’tis conjoined to the peri- toneum, with little or none of this middle produdion ; fpreading itfelf upon the body of the pfoas mufcle, as high as the fpleen, where this part of the peritoneum, that gave a coat to the colon, fpread under the fpleen, re- ceives and fuftains thatvifcus, by taking it into its capacity or folds. §. 642. From thence the peritoneum at the pelvis afcends upward, expanded before the left kidney, and dretched outward on each fide, forwards from that and from the right kidney, before the great blood-veiTels, under the pan- creas ; to which, being continuous, it forms a long produdion, called the tranfverje mejccolcn^ which, like a partition, divides the upper part of the abdomen, containing the domach, liver, fpleen, and pancreas, from its lower ca- vity, filled by the intedines. The lower plate of this tranfverie produdion is lingle, con- tinued from the right to the left mefocolon, and feryps -as. an external coat to a large portion Of the Omentum. i6^ of the lower and defcending part of the duo- denum, but the upper plate, taking a more obftrudted courfe, departs in its way from the bottom of the pylorus, and gives an external lamella to the duodenum ; before which, and before the colon, it extends backward, and joins with the lower plate in fuch a manner, that a large part of the duodenum lies within the ca- pacity of the mefocolon. Afterwards, near the liver, the mefocolon bends itfelf inward, and defcends laterally over the kidney of the fame fide, fo as to include the right colon, which is much diorter than the left, even as far as the Mind worm-like appendix of the caecum, refting upon the iliac mufcle 3 to which appendicle of the caecum a peculiar long detachment adheres, as a beginning to the me- fentery. Thus is the mefocolon terminated al- moft near the bifurcation of the aorta. §. 643. From thence forward the mefentery follows, as abroad pleated produdion, continu- ous with the tranfverfe mefocolon, and extended on the right fide forward and downward from the emerging duodenum j and then from the left or long mefocolon, even as low as the pelvis. Thus the mefentery is formed by the plates of the peritoneum, which lie upon the aorta, extended forward and together, under the right portion of the tranfverfe mefocolon ; and defcending obliquely under the pancreas, it re^ ceives or contains the lono; ferles of the fmall inteftines, within its capacity, difpofed in num- berlefo ferpentine folds. .. M3 f '§.644, 1 66 Of the Omentum, §. 644. The whole feat and extent of tho mefcntery and mefocolon hold a ufeful portion of fat, colledled commonly more in propor- tion as they go longer within the capacity, that is necelfarily formed by the reduplication of their membranes, or plates of the peritonaeum; whence ferves as a ftratum or bed to the veffels, while fome portion of the fat, which was fepa- rated from the arteries, is abforbed again by the veins, in the manner we {hall hereafter obferve, §. 645, The ftru6ture of the omentum an- fwers very nearly to that of the mefentery. But there are many membranes that come un- der this general denomination 01 the lame ftrudure and utility, all compofed of very tender and fine membranes, eafily lacerated, betwixt which the blood-veffels are difpofed reticularly, with fatdepofited in ftreaks near the fides, and in the fame directions with the reti- culated veffels themfelves. The omentum is always a double membrane, the two plates of which are joined together clofely by a very tender cellular fubftance, within which the veffels are diftributed, and the fat collected. And firfl, where the top of the right kidney and the in falcated lobe of the liver, together with |he fubjacent blood-veffels, meet with the duodepurn into an angle, there the external rnembrane of the colon, which comes from the peritonaeum, joining with the other mem- brane of the duodenum, which is alfo from the adjacent peritonaeum, go together over the left kidney backward, and enter into the tranf- verfe fiffure of the liver, for a confiderable lejigth ; Of the Omentum. 167 length ; from whence the external membrane is continued over the gall-bladder which it contains, confirming the vafcular fabric of the liver, very flippery, and tinged of a yellow co- lour. Behind this membranous production, betwixt the adjacent duodenum, right lobe of the liver, and hepatic vefiels, lies a fmall natu- ral opening, by which inflated air is largely re- ceived into all that cavity of the omentum which we ihall prefently defer ibe as a bag. §. 646. From thence, in a courfe continuous with this membrane (645.) from the pylorous and the lefs curve of the ftomach, the outer membrane of the liver joins, in fuch a manner, with that of the ftomach, that the thin mem- brane of the liver is continued out of the foftk of the venal duCt, before the little lobule of Spigelius, into the ftomach itfelf, ftretched both before the lobule and before the pancreas. This is called the little omentum hepatico-gaftricum ; which, inflated, refembles a cone, and, hard- ening, by degrees, when it is without fat, changes into a true ligament (§. 621.), by which the cefophagus and liver are conjoined together. §. 647. But the greoX. gaJirocoJic-omentum is of a much larger extent. It begins at the firft join- ing of the right gaftro-epiploic artery to the fto- mach, where it is continued from the upper plate of the tranfverfe mefocolon (§,641.), and from thence it proceeds forward along the great arch or curve of the ftomach to the fpleen, and, in part, is continued alfo from the right convex end of the ftomach towards the fpleen, M 4 even 1 68 Of the Omentum. even ’till it c 3 egenerates into a ligament, that ties the upper and back-part of the fpleen to the ftomach. This is the anterior leaf of the omentum. §. 648, This anterior leaf, or lamina of the omentum, floats loofely downward before the intefl’nes, often to the navel, fometimes to the pelvis, behind the peritoneum and mufcles of the abdomen, and, making a thin edge, is folded back again upward, fo as to form ano- ther leaf behind, and, like to the former, leaving an intermediate free capacity, by which the fore leaf may eafily remove from the po- flerior, as a fheet of paper is commonly fold- ed, being at length continued for a confider- able extent into the outer membrane of the tranfverfe colon, and laflly terminated in the fmus of the fpleen, by which the large blood- veffels are received. Eeliind the ftomach and before the pancreas, the cavity of this is con- tinued into that of the left'er omentum. §. 649. To the former is continued the omentum cohcum, which arifes on the right fide only from the colon and its external mem- brane, immediately after the origin of the omentum gaftrocolicuin from the mefocolon, with whofe cavity it is continuous ; and, de- parting doubled from the inteftine, forms a pro- dudtion, ending conically, and terminated by a longer or (horter extent, above the intdlinum cscum. §.650. Laftly, ft’om the whole tradl of the colon, ftand out little protuberances or omenta, called appendices epiploides, which arc of a like fabric, and, when inflated, refemble ck'ie Of the Omentum, 169 clofe br confined bladders ; being continued of, a fmall fize and oblorfg figure3 from the outer membrane of the colon, well filled with fat. §. 651. The ufes of the omentum are many. Its common ufe is, together with that of the mefentery, to form an ample fpace of a loofe texture, into which the fat may be poured from the arteries, at the time of fleep and inadivity of body, to be afterwards diflblved by motion, and returned again into the blood by the infor- bent veins, fo as to make a confiituent principle of the bile. Accordingly, you’ll feel the fat of the omentum to be very tenaceous or vifcid. betwixt the fingers, although of a thin con- fidence, and, in its whole body, more pellu- cid than paper. For tliat the fat of this part returns again into the veins, appears from the different bulk and weight of fat, obfervable in the various omenta of different perfons, ac- cording as they lead either an idle, laborious, or morbid courfe of life. To which add, its appearances in various brute animals, with the relation it bears to all the red of the fat of the whole body (§. 21.) : and, by experiment or example in frogs, where this re-abforptlon of the fat may be made evident to the eye j and ladly, from the apparently infiarnmable nature of the bile itfclf. Hither we mud aifo refer the diforders and crudities of digcdion, together with the coldnefs of the domach, obfcrved to follow after cutting out the omentum, and the other ufes following (§. 656, &c.). / §. 652. Eat that the abforbed fat goes from Jaence to the formation of the bile, app-arrbv the lyo Of the Omentum. the courfe of the blood, which all returns from the omentum and mefocolon into the trunk of the vena portarum, and by that into the liver itfelf. The omentum is furnilhed with blood by the gaftrocolic and by each of the gaftro- epiploic arteries, defcending in many fmall branches, and fubdivided in a reticular man- ner : of thefe, the arteries on each fide run to the greatefl; length ; but the inner or pofterior leaf of the omentum has fmall arteries, which go out from thofe of the tranfverfe colon. The omentum colicum has alfo its arteries from the colon, in the fame manner as the fmaller ap- pendices (§, 650.). The arteries of the lefier omentum (§. 646.) come from the hepatics, alfo from the right and left coronaries of the ftomach. §. 653. The nerves of the omentum are very fmall, as being a fat and indolent body; yet it receives fome little branches from the nerves of the eighth pair, both in the greater and in the lefier curve of the ftomach. §. 6 <^4. The arteries of the mefentery are, in general, the fame with thofe that go to the inteflines, the fmaller branches ^f which go off laterally to the fmall glandules and -cellular fat, included within the mefentery. But to the mefocolon, fmall arteries are diftributed on all fides from thofe of the various parts con- nedted to i t, as the intercoftals, fpermatics, lumbals of the renal capfules, and tranfverfely from the fplenic artery, with the pancreatic branch of the duodenum : but in the left mefocolon, there are Of the Omentum. \j\ are alfo fmall arteries detached from the aorta itfelf to the glandulas lumbales. §. 655. The veins of the omentum, in ge- neral, accompany the arteries, and, like them, unite into larger trunks ; thofe of the gaftro- colic omentum from the left fide open into the fplenic, as do thofe of the hypaticogaiiric, vvhich likewife fends Its blood to the trunk of the vena portarum ; thofe from the larger part of the right gaftrocollc omentum go to the me- fenteric trunk, as do thofe of the omentum co- licum, with thofe of the appendices epiploides. All the veins of the mefentery meet together in one, which is truly the trunk of the vena portarum; in forming which, they are firfi; col- letfled into two large arms, of which one re- ceives the mefenterico-gaftro-epiploica, with the colic and iliocolic veins, and all thofe of the fmall intefiines, as far as the duodenum ; the other arm, which goes tranfverfely acrofs the former, which arifes above it, is embraced by the duodenum, and returns the blood of the left colic veins, with thofe of the redlum, ex- cept the lowermofi:, which belong partly to thofe of the bladder, and in part to the hypo- gaflric branches of the pelvis. The vein, which is commonly called hgemorrhoidalis in- terna, is fometimes inferted rather into the fple- nic than into the mefenteric vein. If it be de- manded, whether the omentum has any lym- phatic vefiels ? we an Twer, in the affirmative: fince there are conglobate or lymphatic glan- dules, both in the little omentum and in the paftrocolicum ; al.^o the antient anatomifts have pbferved 172 OJ the Omentum, obferved pellucid veffels in the omentum, and lately a modern has defcribed them for ladeals of the flomach. §.656. Other ufes of the omentum, which may be added to the preceding (§. 651.), are to interpofe betwixt the inteftines and perito- naeum, which, by inflammation, are very apt to grow together ; to keep the former in a fl;ate of free motion, as well among themfelves as againfl: the peritoneum, with but little attri- tion ; and to anoint the mufcular and membra- nous fibres with a mofl: foft oil. For thefe reafons, even in infcdis, there is a great deal of fat placed round the intefllnes. In the large in- teflines, there are a great many appendices of fat, like that of the omentum, which is not ample enough to cover the colon, whofe muf- cular ftripes or portions are larger and more powerful than thofe of the other intefl;ines. §. 657, More than this, the flratum of the omentum ferves to fupport, diredl, and diftri- bute the veflels to connedt the adjacent vifeera, and to exhale a foft oily vapour, which, mix- ing with the exhaling water of the abdominal vifeera, ferves to anoint and lubricate them all for an eafy motion. §.658. The mefentery ferves to fufpend and difplay the inteftines in fuch a manner, that th.ey may move freely, and with a degree of firmnefs; it ferves as a bed to fuftain, and fafely condudt the numerous veflels, nerves, and glandules j of which lafl, we fhall fpeak hereafter (§. 721.) : it alfo gives an external 3 coat Of the Omentum: 173 coat to the inteftines, and forms mod of the ©menta. §. 659. But, moreover, the blood, return- ing through the mefenteric and mefocolic veins, brings with it another principal conftituent part of the bile, and in a conhderable quantity; namely, a fubalcaline watry humour, which is abforbed by the veins from all the fmall inte- ftines, as will be demonftrated in its proper place. Befides this, there is a more putrid water abforbed from the large inteftines, which is foetid, and nearly approaches a volatile alca- line nature, as may appear from the nature of the foEces themfelves, from whence it is ab- forbed ; and ’tis likewife manifeft from the greater compa6tnefs and drynefs of the feces, when they are retained a longer time in the colon. This faponaceous water is, therefore, a fluid in itfelf, and rendered more fo by an in- cipient putridnefs ; and confequently it ferves to reduce the tenacity of the oil belonging to the omentum and mefentery, fo as to keep it from congealing. But more efpeciallyin the bile, it conftitutes the acrid alcaline quality with which this humour abounds ; and from thence comes the great tenuity and faponaceous force of the bile, fo ufeful to dyers and painters. LEG- LECTURE XXVI. Of the spleen. §. 660. r"| H E fpleeti itfelf is one of thofd J|_ intermediate vifcera, which fend their blood to the liver. It is a bluifh, pulpy, fomewhat oval vlfcus, fomething like a mafs of congealed blood in its conhilence, having fre- quently a notch or incifure in its oval circum- ference ; whence it is convex towards the ribs, ccwicave inwardly, and circumfcribed with two margins or edges, one anterior , the other pofterior; of which the former, with a full ftomach, lies next the diaphragm, and the latter upon the left kidney. It is connected to the ftomach by the little omentum (§. 646.), and above that, by the ligament from the large omentum, fup- ported by the fubjacent colon, and by another ligament (§. 641, ult.) behind the renal cap- file, to which, and to the kidneys, it adheres by a good deal of cellular fubftance, with the peritonaeum. It allb receives the peritonaeum from the diaphragm, under the denomination of a ligament in the back-part of its hollow linus, behind the entrance of its veilels. The lituation of it varies with that of the ifomach itfelf, which it follows (§, 620, ult.) j for when that is empty, the fpleen is raifcd perpendicu- larly, fo as to place its extremities right up and down ; but when the itomach is full, the middle curve or arch of it arifcs upward or foreward, and at the fame time obliges Of the Spleen. 175 the fpleen to change its fituatlon, fo as to lie tranfverfely with its lower end forward, and its upper one backward. Nor is the bulk of it lefs variable ; for, being of a very foft and loofe texture, it grows larger by diftention when the ftomach is empty, and becomes lefs again when its blood is prefled out by the diftention of the full ftomach againft the ribs. From hence the fpleen is found large, in thofe who die of lingering difeafes ; but in thofe who die fuddenly, and in full health of body, it is fmall. Another motion of the fpleen is, that of defcending with the diaphragm in infpiration, and afcending again in expiration ; and befides this, the fpleen fre- quently varies in its fituation, with that of the colon. Frequently there is a fecond or lefs fpleen placed upon the former. §. 661. The blood-veflels of the fpleen are large, in proportion to its weight. The arte- rial trunk comes from the coeliac, the upper branch of which, proceeding in a ferpentinc courfe, above and behind the pancreas, to which it gives branches, as well as to the me- focolon, ftomach and omentum, is, at length, incurvated in the direction of the fulcus or notch of the fpleen, which it, after a man- ner, perforates by feveral diftindl branches, fuftained at the right extremity by the omen- tum gaftrocolicum. The fplenic vein, which accompanies the artery, is conliderably fofter than any other veins of the body ; it forms the principal left branch of the vena portarum. Beftdes thefe, the fpleen receives fmall arteries from the great coronary, defcending behind the pancreas, 176 Of the Spleen. pancreas, and fometimes from the Internal hx~ morrhoidal. The vafa breviaof the fpleen and ftomach, we have mentioned (§. 627.) ; and its ligaments receive fmall arterial twigs or circles, from the phrenics, intercoftals, and thofe of the renal capfules. In like manner alfo, the veins in the fpleen, and thofe which join it to the flomach, communicate with the phrenics, and with the veins of the renal capfules. §. 662. The lymphatic velfels of the fpleen, I believe, are oftner talked of than feen ; they are defcribed to arlfe in the duplicature of the fplenic coat or membrane (of which there is none at all) and from thence to proceed on to the receptacles of thechyle, very evidentin acalf. §. 663. The nerves of the fpleen are very fmall, from whence it is capable of but little pain, and is very rarely inflamed. They arife from a particular plexus, compofcd out of the poflerior branches of the eighth pair attheflo- mach (§. 628.), and ot certain branches from the large gangliform plexus, wliich produces the fplenic trunk of the intercoflal nerve, from whence the branches furround tiie artery into the fpleen. §. 664. The fabric of the fpleen appears to be much more Ample than has been commonly believed. For it is compofed, both in us, and in calves, altogether of arteries, and of veins ; the former of winch, after fpending themfelves in a great number of fmall branches, are at length thickly fubdivided Into very foft brufli- like bunches, verydiUicult to fill with injedtion, terminating in circles, bv which there is a ready paffage for liquors into the correfponding veins. The Of the Spleen. 177 Thefe circles, with their parallel branches, form a fort of bunches, like a pencil brufli, but of a fhorter rounder kind, whence many have miftaken them for glands. Nor does the in^* jedlion, rightly managed, ever efcape from the veffels into the cellular fubftance ; befides which, there are no other cells or intervals. Every little arterial trunk, with the fmaller twigs that proceed from it, are each of them furrounded by a very fine cellular fubftance, or web- work, in the fame manner with the fmall vefifels of all the other vifcera ; and thefe together, make up the whole body of the fpleen, outwardly furrounded by a membrane, which is not very tough, continued from the peritonaeum. §. 665. Hence we obferve, that the fpleen contains more blood, in proportion, than any of the other vifcera, fince it has no mufcles, fat, air-vefiels, or excretory duds, interpofed be- twixt its blood-veflels. We learn alfo, from obfervation, that the blood of chis part hardly ever congeals; from the abundance of its volatile or bilious falts : but it looks of a dark brown colour, and may be eafily diluted ; whence one may compare it almofi; to the blood of a foetus. §. 666 . The want of an excretory dud to the fpleen, has occafioned the ufe of it to be doubtful, and controverted throughout all ages of anatomy. To us the fabrick itfelf feems to lead to the ufe following. We fee by the veflcls a greaterquantity of blood is imported tothefpleen, (§. 66 1.) and with a flower motion, from the ferpentine courfe of the artery ; but at the time when the ftomach is empty, this blood comes, VoL. II, N and 178 Of the Spleen. and is received in a greater quantity by the fpleen, not now fo much compreffed, therein to ftagnate, as it would Teem, plainly from the great proportion of branches, to the trunks in this part; to which add, the difficult courfe or flow circulation which the blood meets with in pafling from the fpleen through the liver : from hence the frequent tumours and fcirrhofities of the fpleen ; and from hence the immenfe quan- tity of blood, with which the fpleen is in every point diftended, like a drum, the like of which we do not fee in any other part. Here, then, the almoft flagnant blood, fomented with heat, attenuated, and in a manner diflblved by the putrid faeces of the adjacent colon, enters thus upon the firfl; fteps of a begun putrefadion, as we learn by experiments, both from its colour and confiftence. But the greater fluidity of the blood herein, proceeds not only from this diflb- lution, but becaufe all its watery juices, that enter by the artery, return alfo again by the veinj for there are no fecretory duds in the fpleen. §. 667, Moreover, when the ftomach is full of food or flatus, the fpleen is thereby com^ preffed into a narrower compafs, againfl; the ribs, and fuperincumbent diaphragm, by which means the blood that before was fcarce able to creep alon? through the fplenic veins, being now preflTe 1 out more plentifullv, returns with a greater cel?rity towards the liver, till mixing with the fluggiffi blood in the trunk of the porta, repleniffied with the fat, or oil of the omentum and mefentery (§. 652.) it dilutes or i^hins the fame;, and renders it lefs apt to flag- nate Of the Spleen, 179 nate or congeal ; and at the fame time, It con- duces to form a larger fecretion of bile at a time when it is mbft wanted, viz. to flow plentifully to the food now under digcflion. The fpleen, therefore, feems to prepare the blood, that it may fupply a fort of watery juice to the bile ; but fuch as is probably of a fubalcaline nature, and rendered fomewhat fharp, or lixivial by the remora of the blood. §. 668. Hence we may be able to folve the quefl:Ion, v/hether the fpleen be like the lungs of a fpungy or cellular fabric ? and whether the blood is poured out into thofe cells, fo as to ftagnate in its way to the veins ? or whether it be there diluted with fome juice fecreted by pe- culiar glands ? We fee nothing of this is de- monflirable by anatomy ; nor does the liquor or wax Injefled, ever extravafate Into the cellular fubilance, unlefs urged v/ith much greater vio- lence, than nature ever ufes or intended. If it be demanded, whether difeafes do not fome- times demonftrate a fort of glandular fabric in this part, and comparative anatomy the fame ? an anfwer may be had from (§. 185.). As to the old queftion, whether the fpleen brews up an acid, to whet or fharpen the flomach ; that opinion has been long difcarded, as repugnant to the nature of all the animal juices. If it be aiked, whether the fpleen be not an ufelefs mafs, as it might feem to be, from the little damage an animal fuftains, after it has been cut out ? we anfwer, that a robufl; animal, fuffering but little injury from the lofs of a part, does not prove it to be ufelefs ; on the contrary, N 2 we i8o Of the Spleen, we experience, after fuch an experiment has been made, that the liver becomes fwelled and difordered, makes a lefs quantity of bile, and of a darker brown colour, while the animal is perpetually troubled with flatulencies, gripes, or indigeftion, all which are to be afcribed to the vitiated nature of the bile, an obftrudlion of the liver, and an imperfect or weak di- geftion. LEC- lecture XXVII. Of the Livery Gall-Bladder, and Bile. §. 669. ^ |"^HE liver being the largeft of all ^ the glands in the body, fills up a very large part of the abdomen in its upper chamber, above the mefocolon j and is yet ftill larger in proportion, in tl^e foetus. Above, be- hind, and to the right fide, it is covered by the fuperincumbent diaphragm, from which it re- ceives the peritonseum for a covering, under the denomination of ligaments, chiefly in three places; namely, fir ft, in a tranfverfe pofition, from the tip of the enfeform cartilage, a little more inclined to the right fide than the middle of the diaphragm, which takes a long courfe round the convex part of the liver, to the pafTage of the vena cava, through the tranfverfe fulcus of the liver, from whence the peritonreum de- fcends laterally folded together, of fome breadth forwards, under the name of ligamentum fuf- penforlum, which divides the greater right lobe from the leffer left lobe of the liver ; and then, parting from its duplication, it expands into the proper coat of this vifcus (§. 621.) which is white, fimple, and thin, like the external coat of the ftomach ; and under this is fpread the cellular fubftance, by which it is intimately conjoined with the flefli of the liver. To the lower margin of this, joins the umbilical vein, which in an adult, being dried up, leaves only N 3 a fma'l 1 82 Of the Liver. a fmall cord, furrounded with fome portion of fat. In the extremity of the left lobe, and fometimes at its edge, or convex part, a mem- brane goes to the liver, from the diaphragm, which in children, and other young fubjedts, is fi'equently to the left fide of the cefophagus, but in adults to the right fide ; yet always conjoined both to the gula, and to the fpleen, whenever the liver, or this ligament are very large. The right ligament ties the large right lobe, in its back part, to the diaphragm. Betwixt this and the middle lobe, for a confiderable way, but without any apparent length, the membrane of the right lobe of the liver is often conjoined by the cellular fubfiance, to the diaphragm; more efpecially in old fubjedls, for in the feetus it is eafily feparated ; and then it continues its courfe betwixt the fufpenfory and left ligament, joined as before, with the peritona?um, fo as to re- femble a ligament. But alfo from the right kidney, the peritoneum going off to the liver, makes a reduplication like a ligament, and con- joins together the lefs omentum, with the con- tinued ioofe productions of the mefocolon (§. 645.) with the liver, flomach, and duode- num ; and likewife the faid mefocolon, to the pancreas. Thus the liver is (ufpended in the body, with a confiderable degree of firmnefs, yet fo as to be allowed a confiderable liberty to move and be varioufly agitated, raifed and depreffed, by the aClions of the diaphragm. §. 670. Moreover, the inner concave face of the great lobe of the liver, lies with its forepart be- fore the colon, and in its back part correfpondsto • 0 the Of the Liver o 183 the left kidney. The middle linus of this lobe lies near the duodenum, which is by the gall- bladder tinged yellow ; and alfo lies contiguous with that part that conducts the great blood- velTels. The left lobe extends largely over the ftomach, and frequently, efpecially in younger fubjedts, goes beyond the cefophagus, into the left hypochondrium. The lobule, in the mean time, adapts itfelf to the leffer curve of the fto- mach. But moreover, the pancreas is covered by the liver, and in a manner connedled with that to the right renal capfule, by a good deal of cellular fubftance, (§. 671.). The figure of the liver is difficult to defcribe. It begins in the cavity of the right hypochondrium, by a very thick folid protuberance, convex towards the diaphragm, and hollow towards the colon and kidney, which make impreffions into the liver, diftinguiffiable by fmall lines or eminen- cies, continued as a portion to the longer ap- pendix of the lobule. After this, the liver, fomewhat like a pyramid, grows flenderer, and thinner, and is at laft terminated or extenuated into a tip, almoft triangularly, which paffing into the left hypochondrium, goes before the cefophagus, in young fubjedls, as far as the fpleen, but in adults it often ends ffiort of the cefophagus. The upper and back part of the liver is every where rounding or protuberant, covered by the diaphragm, and in a large part, which is fomewhat flatter, towards the left fide, it is placed under the heart : but the lower and pofterior furface being varioufly figured, refts itfelf upon the duodenum, colon, flomach, N 4 pancreas, 184 Of the Liver. pancreas, and right renal capfule. For in the liollow fide of the liver, there are feveral little furrows, which divide the furface into feveral regions, and which did not efcape the notice of the antients. §. 672. The principal of thefe furrows. Is extended tranfverfely, from the right fide to the left, for near two thirds of the liver, beginning flender in the right lobe, and enlarging towards the left. Before this tranfverfe fulcus, there is an excavation in the right lobe for the gall- bladder, and then another for the anonymous lobule ; after which comes the fofla of the um- bilical vein, extending tranfverfely downward, often covered with a little procefs or bridge that joins the anonymous to the left lobe ; but behind the great fulcus, firft towards the right fide, there is a flender tranfverfe eminence, growing broader to the right, and moderately hollow, by which the great blood veflels are conduced into the liver ; and this little valley was by the antients denominated the port(e^ or gates of the liver. In this place there is a lo- bule, as I fliall defcribe, that joins to the right lobej viz. the poflierior lobule, which is not very juftly called after the name of Spigelius ; and this projects obtufely conical, like a nipple, into the lefs curvature of the floinach. The thick root of this and the former excavated eminence, begins from the convex part of the liver, at the diaphragm, and from thence on the right fide, is impreffed with an oblique fulcus or furrow, mclined to the right fide, for the paflage of the trunk of the vena cava, defcending from the heart Of the Li^er. 185 heart, in the fame diredtion, to the lumbal yer- tebrsE j and is frequently furrounded by a pro- dudlion of the liver, like a bridge, or even fo as to complete the circle, and form a tube. The left end of the lobule terminates another fofla, almoft perpendicularly downwards, but inclined to the left, which beginning tranfverfely by one end, terminates at the vena cava, palling through the diaphragm. In this linus was lodged the dudtus venofus in the foetus, of which there are fome remains to be perceived alfo in the adult. All that lies beyond this to the left, is a lingle hollow, equally defcending, and incumbent up- on the ftomach, over which it is extenuated to a thin edge. §. 673. This huge gland is proportionably fupplied with very large velTels, and of various kinds. The artery, which is indeed conlider- able, being the greater right portion of the caeliac, emerges from the trunk forward, and to the right, going tranfverfely, before the vena portarum, and after giving off a fmall coronary with the pancreatic and duodenal artery, the remaining large trunk goes on and enters the liver, commonly by two branches, of which the left is betwixt the umbilical foffa, the venal dudt, pofterior lobule, with the left, and the anonymous lobe, alfo the fufpenfory ligament ; and this inofculates with a branch of the phrenic and epigaftric. The right hepatic artery enters the liver lower, covered by the biliary dudls j and having reached the right with the anony- mous lobe, there fends off, in one fmall trunk, the cyflic artery, which foon after divides into two, i86 Of the Liver, two, and is fpread both under and upon the gall-bladder, covered by the common coat of the liver, and fupplies not only the gall-bladder and biliary duds, with its branches, but like- wife fome part of the liver itfelf, From the left branch, or fometi'mes fVom the trunk of this, arifes a fuperficial artery to the biliary duds, anonymous lobe, and glandules of the porte. Befides the cseliac artery, there is frequently a large right branch produced from the mefente- rica major, creeping behind the pancreas ; and this ferves in dead of the eighth branch of the hepatic artery from the casliac. But likewife, the greater coronary, which is the firft twig of the csliac, always gives fome ramifications to the left lobe, and to the foffa of the dudus ve- nofus, which lad branch is often very confi- derable. The led'er arteries are thofe fent to the liver, from the phrenic mamaries, renal and capfulary arteries. §. 674. But the veins of the liver, contrary to what we obferve in any other part, are of two very different and didind kinds : namely, the vcnas portarum, which receiving all the blood of the domach (§. 627.) of the intedines and mefentery (§. 712.) of the fpleen (§. 661.) omentum (§. 652.) and pancreas, at length meet together into two arms or branches; namely, the tranfverfe, fplenic, and thcdefcend- ing mefenteric; then unite into one trunk, which afcends large, compofed of drong membranes, fil'd a little bent behind the duodenum, where it receives the veins from its right fide, together with the leffer coronary, whence going higher to Of the Lher. 187 to the right fide, it again divides into two large trunks in the finus of the lobule (§. 672.) of the liver. Of thefe two the right, being Ihorter, larger and bifurcated, receives the cyflic vein, and then fpreads as an artery through its next lobe. The left runs on through the remaining part of the tranfverfe finus in the liver, and after giving veins to the lobule, wdth the anonymous and left lobe, it is incurvated and enters the umbilical foffa, from whence about the middle it immerges and ramifies through the liver. There are fome Inftances, in which the venal branch of the pofterior lobule has been fent diftindl from the vena portarum. §. 675. The vena portarum is on every fide furrounded with a good deal of cellular, fub- ftance, derived to it from the mefentery and fpleen, of a fliort, clofe and ftrong texture, made firm by the addition of the more denfe and firong membranes, w'hich cover the aorta itfelf. Intermixt with this cellular fubftance, are alfo many of the fmaller vefiels and hepatic nerves, which all come together under the denomina- tion of a capfula j but improperly, fince it is al- together nothing more than the cellular fub- ftance, without one mufcular fibre. By this the vena portarum is condudted to the liver, and firmly fuftained j infomuch, that the branches being cut, maintain the round lights of their fedlions. But each branch of this veflel, is again divided, fubdivided, and infinitely ramified within the fubftance of the liver, after the man- ner of arteries, till they at length produce the fmalleft capillaries. In this courfe, every branch of i88 Of the Lher. of the vena portarum, is accompanied with a focial branch of the hepatic artery, creeping up- on the furface of the vein, and the contiguous hepatic duds, almoft in the fame manner as the bronchial arteries ufually creep along the rami- fications of the wind-pipe in the lungs j while, in the mean time, both the artery and the vein are conneded to the branches of the biliary duds, to which they are continued by a thin cellular fubftance, like a fpider’s web. The fedion of any branch of the vena portarum, is always lefs than the trunk, from whence it is derived j whence the lights of all the branches together, greatly exceed that of the trunk (§. 36 ): from whence follows a great fridion or refiftance (§. I47.)> and a retarded motion (§. 133.), after the fame manner as we obferve in the arteries, §. 676. But fince the blood is in this manner conveyed through the liver to the branches of the vena portarum, together with the hepatic artery, it mud of courfe be conveyed back again, by fome other veins : and therefore, we lee, that the ex- treme branches of the vena portarum, and he- patic artery, inofculate and open into another clafs of veins, which are brandre^ of the ca'ca^ which ariling from all points of the liver, run together towards the pofterior gibbous part of the liver, into branches and trunks, which are at lad about ten or eleven in number. The led'er of thefe trunks, and greater number of them, pafs out through the poderior lobule of the liver, and go to the cava, through the ful- cus, that lies on the right fide of the lobule, often of the Liver. often completed into a circle by a fort of bridge, or production of the liver, from whence they afeend together through the diaphragm, to- wards the left fide. Two or three trunks much larger than the former, are inferted into the fame cava, clofe to the diaphragm, whofe veins they often take in by the way. The branches of the vena cava are, in the adult, generally fewer and lefs than thofe of the vena portarum ; which is an argument that the blood moves quicker, and with lefs refi fiance or friCtion through the hepatic cava (§. 140.); as is the Gourfe of the blood into a lefs light, or ca- pacity, by which it is always accelerated, when there is too a comprefiing force (§. 140.). As to any valves at the openings of thefe branches into the cava, I know not of any which deferve to be regarded. The trunk of the vena cava, paffing through a foramen of the diaphragm, obtufely quadrangular, furrounded and termi- nated by mere tendons (§, 289.), is thereby rendered not eafily changeable (§.413.); and having furmounted this opening of the dia- phragm, it then immediately expands into the right auricle. The final ler veins of the liver creeping about its furface, go to the phrenics, renals, and azygos ; or at leaft there is a com- munication betwixt thefe and the hepatic veins. §. 677. That the blood is fent to the liver, from all the forementioned vifeera of the ab- domen (§. 674.), conducted by the vena por- tarum, to the ports, is proved by a ligature, by which any vein betwixt the ligature and the parts fwells, but the porta itfelf^ above the liga- ture, 190 Of the Liver. ture, grows flaccid and empty. But that it af- terwards goes through the liver to the cava, ap- pears by anatomical injections, which fhow open and free anaftomofes, or communications betwixt the vena portarum and the cava, toge- ther with the common nature of the veins going to the cava. Again, the difficult diflribution. or pafTage through the vena portarum, like to that of an artery, together with its remotenefs from the heart, and the oily or fluggifh nature of the blood itfelf, occafion it to ftagnate, ac- cumulate, and form fchirrous fwellings in no part oftner than the liver. But this danger is diminifhed by the motion of the adjacent muf- cles, and by the refpiration, as it is increafed by inactivity, with four and vifcid aliments. But hitherto, we have been fpeaking of the adult liver, in which both the umbilical vein, and the duCfus venofus are empty and clofed up, although they continue to cohere with the left branch of the vena portarum. §. 678. The nerves of the liver, are rather numerous than large, whence it is capable of no very great pain. They have a twofold ori- gin ; mofl: of them arifing from the large gang- liform plexus, made by the fplenic branch of the intercoftal nerve, w'ith the addition of a branch from the poflierior plexus of the eighth pair ; they accompany the hepatic artery, and playing round its trunk, are diitributed with that and the portal branches, throughout the liver. Another fafciculus of nerves, ufually en- ters with the duClus venofus, and arifes from the- Of the Liver, 191 the poflerior plexus of the eighth pair, but fometimes from the great plexus. §. 679. The lymphatic veffels of the liver are numerous, being conftantly and eafily to be feen about the porte. They arife from the whole concave furface of the liver and gall-bladder, and run together into a plexus, furrounding the vena portarum, going afterwards to the fmall conglobate glandules, feated before and behind the faid vein, from whence they meet together in one trunk, which is one of the roots of the thoracic dud:. Upon the convex part of the liver are defcribed other lymphatics, whofe infertion is not well known ; but it is hardly probable, that they enter the cava, nor have I been able to find that they lead to the root or ciftern of the thoracic dud. §. 680. The interior or intimate fabric of the liver being more minute, is proportionably more obfcure. The ultimate fmall branches of the vena portarum, cava, and hepatic artery, together with the bilious duds, which we fhall foon defcribe, are united together by means of the cellular fubflance (§. 675.) into a fort of mulberry-like bunches, of an hexagonal fhape, in the fmaller parts of which there are mutual anaftomoles, or inofculations, betwixt the portal branches and hepatic artery, with the roots of the vena cava on one fide, and of the pori bi~ liarii of the liver on the other fide ; which laft demonftrate their inofculations by anatomical injedions j for liquors injeded by the vena por- tarum return again through the ultimate pore ©r dud gf the bile, §. 681. 192 Of the Liver, §. 681. Manyeminentanatomifts have taught that the forementioned bunches or primary por- tions of the liver, arc hollow, having arteries and veins, fpread upon their external furface, and depohte the bile into their cavity, after it has been fecreted from the circles of the vena portarum. For this they alledge arguments, taken from the comparitive anatomy of animals, whofe liver is made up of more round and de- finite bunches j and from thofe difeafes, which demonflrate cells and round tubercles, filled with lymph, chalk, or other recrementitious matter. To this they might have added the thick flug- gilh nature of the bile itfelf, by which it is re- lated to mucus, and the analogy of the gall- bladder for infpifiation. §. 682. But greater diligence and accuracy in anatomy, will not allow any follicles, into which the fmall fecretory vefTels can pour out their contents ; for fuch would intercept the courfe of anatomical injedlions, and give us the appearance of knots intermediate, betwixt the fecretory veffels and the biliary pores, which we have never yet been able to fee •, for the wax flows immediately, without any interruption or effufion, in a continued thread, from the extre- mities of the vena portarum, into the biliary dudls. But again, a follicular or glandular fabric is neither allowable in the liver, from the great length and flendernefs of the biliary duds. For all follicles depofit their contents into fome fpace, immediately adjacent, and are unfit to convey their fecerned fluid, to any length of courfe, which might deflroy the part by the velocity X)f the Livet*. 193 velocity received from the artery. As to the follicular morbid concretions, they are made in the cellular fabric. Another argument againft the follicles, is the watery fluidity of the bile, as it comes out of the liver. §. 683. Again, we are perfuaded, that no bile is feparated from the hepatic artery, be- caufe that would render ufelefs the great arte- rial trunk of the porta ; whofe office in fecre- tion, appears plainly by its continuations with the biliary dufts, in a manner more evident than that of the artery : but it appears by experi- ments, alfo, that the biliary fecretion continues to be carried on after the hepatic artery is tied, by a ligature ; add to this the largenefs of the biliary dudts, in proportion to fo fmall an arte- ry, with the peculiar nature of the blood con- veyed by the portal branches, fo extremely well fitted for the formation of the bile. For we have already feen, that it contains oil, and lixi- vium, which abound more in the bile, than in any other humour of the body ; for it takes in the faponaceous water of the ftomach, by the abforbing veins, together w'ith the fubfcetid al- calefcent vapours of the abdomen, which tranf- pire through the whole furface of the inteftines, flomach, omentum, liver, fpleen, and mefen- tery, which are abforbed again by the veins, as we know by inconteffable experiments of ana- tomy; and finally, the alcalefcent femiputrid or lixivial humidity that is drank up from the faeces, while they continue to dry in the large inteflines, is taken up by the internal ha?morr- hoidal veins, from whence that bitternefs, alca- -VoL, II. O idcent. tq4 Q/* Liver, lefcent, and putrelcent difpofition of the bile is derived. But, on the contrary, in the blood of the hepatic artery, we can find nothing pecu- liar to the nature of the bile, nor any near rela- tion to it. §. 684. Since, therefore, the vena portarum conveys the blood ready charged with biliary matter, fit to be fecreted in the leaft acini, or vafcular bunches of the liver (§. 683.), and thefe have an open free palTage, without any im- peding follicles; it thus flows from the ultimate branches of the vena portarum, into the be- ginning roots of the biliary duds, through which the bile is drove by the force of the blood, urging behind, as well as by that of the dud itfelf, aided by the comprelTure of the liver again ft the other vifcera, by the motion of the diaphragminrefpiration(§.669.) ; thence pafling through larger branches, it is at laft urged into two trunks of the large biliary dud of the liver, which trunks meet together in one upon the vena portarum, in the tranfverfe folTa of the li- ver, near the anonymous lobule. §. 685. The fabric of this dudus hepaticus, is made up by a ftrong nervous membrane, like that of the inteftines, over which is fpread an external and internal cellular membrane, and is internally lined with a loofe villous tunic, ele- gantly reticulated, but afperated with many fmall pores and finufes, and continued with that of the inteitine itfelf. But there is here no muf- cular fabric apparent. §. 686. The hepatic dud, thus formed, goes on upon the vena portarum, by the right fide of Of the Liver. 195 of the artery towards the pancreas j and then defcending to the left, covered by fome part of that gland, it goes to the lower part of the fe- cond flexure of the duodenum, and is inferted backward, about fix inches from the pylorus, through an oblique, oblong finus, made by the pancreatic dud, together with which it opens by a narrow orifice. The faid finus runs a great way through the fecond cellular coat of the duo- denum, obliquely downward ; then it perforates the nervous coat, and goes on again obliquely, next to the villous tunic, w'hich it at lafl; perfo- rates into the duodenum, by a protuberant, long, and wrinkled produdion, like a papilla. Thus there is almofl; the length of an inch taken up betwixt the firft infertion, and the egrefs of this dud through the coats of the duode- num, by a finus, which furrounds and receives the dudus choledocus, in fuch a manner, that when the coats of this inteftine are diftended by flatus, or clofely contraded by a more violent periftaltic motion, the opening of the dud mull: be confequently comprefled or Ihut ; but when the duodenum is relaxed and moderately empty, the bile then has a free exit. Thus any regur- gitation from the duodenum, is hindered by this obliquity, and wrinkling of the dud, eafily prefifed together or clofed, and joined with aquick fucceffion of frdh bile, defcending perpendicu- larly from the liver. Nor does wind inflated into the inteftine find any paffage ’into the dud. §. 687. But in the entrance of the ports, this common dud receives another lefs canal of the fame kind, which lies for a good way pa- O 2 ralicl J96 Of the Liver. rallel with itfelf from the gall-bladder, making its infertion in a very acute angle j and this, which is called the cyftic du6t, from its origin, is fometimes firft increafed by another fmall dud; from the hepatic, before its common in- fertion. This dud is formed by the gall-blad- der, as a peculiar receptacle for the bile, given to mofi: animals; but is abfent in fome, efpecially thofe of a fwifter foot : it is placed in an exca- vation of the right lobe of the liver (§. 672.), to the right fide of the anonymous lobule, in fiich a manner, that in infants or children, it lies wholly within the edge of the liver, but in adults projeds confiderably beyond. Its fitua- tion is almofl; tranfverfe, with its neck afeend- ing from before backward. §. 688. The figure of the gall-bladder is va- riable, but in general like that of a pear, termi- nated in its forepart by an obtufe hemifpherical end, which is impervious, gradually diminifh- ing backward ; the neck or tip of this truncated cone being infleded upwards againfi; itfelf once or twice, and tied together by the cellular fub- ftance belonging to it, makes then another fmall flexure upward, and begins the cyftic dud, which from thence goes on towards the left fide, to the hepatic dud. Within this dud, there are many protuberant WTinkles, formed by the numerous cellular bridles, which tie them together; and thefe wrinkles conjundly, in the dry gall-bladder, reprefent a kind of fpiral valve, but being altogether foft and alternate in a living perfon, they do not ftop, only lelTen the courfe of the bile, as we are affured from experi- ments. Of the Liver. igy ments, by preffing the gall-gladder, and by in=- Nations. §. 689. The outermoft coat of the gall-blad- der covers only its lower fide, being the com- mon covering of the liver itfelf, ftretched over the gall-bladder, and confining it to the liver within its proper finus. The fecond coat is the cellular fubftance, and of a loofe texture. The third coat confifts of fplendent fibres, chiefly lon- gitudinal; but fome obliquely interfering each other, fome circular, and others in various di- redtions. Next to thefe come the nervous coat, then the fecond cellular, andlafl; the villous tunic; which are all found here as in the inteftines, except that the laft, in the gall-bladder, as well as in the biliary dudls, is wrinkled into a fort of reticular folds, as alfo is the cellular. With- in the gall-bladder, but more efpecially about its neck and middle part, we obferve mucife- rous pores, capable of receiving a horfe hair ; and befides thefe, the exhaling arteries difeharge fome quantity of a watery humour into the ca- vity of the gall-bladder, as we obferve in other cavities. §. 690. Into this fmall bladder is depofited the hepatic bile, whenever its courfe is impeded thro’ the common dudtus choledicus, or when the entrance into the duodenum is comprelfed, either by flatus or any other caufe. Accord- ingly, we find the gall-bladder extremely full, whenever the common biliary du£l is obflrud:- ed or comprefied by fome feirrhous tumour, whence the gall-bladder is fometimes enlarged beyond all belief; and if the cyftic duft be tied O 3 with 19S Of the Liver. with a ligature, it becomes fwelled betwixt the ligature and hepatic dudt; and in living animals, the hepatic bile vifibly diftils into the wounded gall-bladder, even to the naked eye. The re- trograde angle, or diredtion of this dudl, is not repugnant to fuch a courfe of the bile ; for a very flight preffure urges it from the liver into the gall-bladder ; and even wind may be eafily drove the fame way, more efpecially if the duodenum be firft inflated. Nor does there feem to be any fort of bile, feparated by the gall-blad- der Itfelf. Whenever the cyftic dudt is ob- flrudled by a fmall flione, or a ligature made up- on it, we find nothing feparated into the gall- bladder more than the exhaling moifture, and a fmall quantity of mucus, fecreted from the pores or follicles of the villous coat (§. 689.) beforementioned. In many animals, we meet with no appearance of any gall-bladder, when at the fame time there is a plentiful flux of ftrong well prepared and falutarybile, difeharged into their inteflines. Again, it does not feem probable, that the branches of the vena porta- rum can feparate bile into the gall-bladder ; for that vein in itfelf is a mere condudory vef- fel : nor can any be feparated from the hepatic ar- tery ; for it mufl; be vafHv beyond probability, that fuch a flrong bile as that of the gall-blad- der (hould be feparated from a milder blood than that of the porta, moved fwiftly through the hepatic artery (§. 683.). All the bile, therefore, which the liver fends to the gall- bladder, arrives only through the cyftic du6l : for in man there are no other dudts betwixt the Of the Lher. 199 the gall-bladder and the liver: the truth of this we are alTured of, by applying ligatures as be- forementioned ; alfo from calculous obftrudlions, with a careful diffedlion, and exadt fcrutiny into the parts ; by which it appears, that nothing either diftils from the liver, or from the gall- bladder; nor are any other veffels wounded be- tides arteries and veins, when the gall-bladder is enucleated or feparated from the liver. §. 691. Therefore a portion of the hepatic bile being received into the gall-bladder, diere Magnates, only a little fhookby the refpiration ; there, by degrees, exhale its thinner parts, which, as we fee, filtrate through, and largely penetrate the adjacent membranes. Moreover, being a fluid of an oily fubalcaline nature, digefting in a warm place, it grows fharp, rancid, more thick, bitter, and of a higher colour : for this is all the difference betwixt the cyftic and hepatic bile ; which lafl: we find weaker, lefs bitter, lighter coloured, and of a thinner confiftence, while it remains within its proper hepatic dudls. That this difference betwixt them proceeds only from flagnation, appears from fuch animals as have only a larger poms hepaticus, inftead of a gall- bladder : for here we find the bile, which Mag- nates in the large hepatic pore, is confiderably more bitter than that in the fmaller pores of the liver ; but in us the gall-bladder gives this parti- cular advantage, that as we take food only at flated times, it can colledt it more abundantly from the liver, when the ftomach being empty has no call for the bile, that afterwards it mav be able to return it in an improved flate, when O 4 the 200 Of the Liver. thedigeflionof incumbent alimentfolllcitsamore plentiful and neceflary flow of bile into the duo- denum ; and this flow of the bile is quicker in proportion through the cyftiq dudl, as the fedti- on of that dudt is lefs than the fedion of the gall-bladder. §. 692. The ftomach, indeed, itfelf, hardly makes any preffure upon the gall-bladder, only by the contiguous beginning of the defcending duodenum. But when the ftomach is extremely diftended, and in a very full abdomen, it makes a confiderable preffure both upon the liver and duo- denum; by which the gall-bladder is urged, and its bile exprcffed. Thus the bile flows through a free paffage, from the gall bladder into the common dud, and by that into the duodenum; and this it does more eafily in perfons lying on their back ; in which pofture the gall-bladder is inverted, with its bottom upward. Hence it is, that the gall-bladder becomes fo full and turgid after falling. But that the bile coming from the gall-bladder does not flow back again into the liver, appears from the continuity of the cyftic and common dudus choledocus, with the angle that interrupts the courfe from them towards the liver, and the refiftance of the new bile, advancing forward from the later. The expulfive force of the bile is but little more than that of the preffure received from the ftomach, diaphragm, and abdominal mufcles ; for as to any mufcular force, reftding in the fibres of the proper membrane, which may be thought to contrad the gall-bladder, it muft be very weak and in confiderable. But the hepatic bile conti- nually Of the Liver. 20 1 Dually flows this way, even after the cyflic du£t is tied, unlefs there happens to be fome obftacle at the opening of the dudtus choledocus, which feldom continues long. Nor is it cre- dible, that all the bile firfl: pafles through the gall-bladder, in its way from the liver, before it enters the duodenum j for there is no perpe- tual obflacle or refiftance to turn the bile to- wards the gall-bladder, out of its high road or ’ open way to the inteftine ; for the way into the common biliary dud; is larger and more dired ; but the cyftic dud, being a great deal lefs, even than the hepatic, cannot, therefore, be defigned for receiving all the bile nature In- tended to flow through thofe fo much larger paflTages ; again, the dudus choledocus, being fo much larger than either the cyftic or hepatic, is, by the fame rule, defigned to carry more than the bile of either of them alone. In many animals, the hepatic dud conveys the bile into the intefline, without any communi- cation with a gall-bladder or acyftic dud j and, in other living animals, where there is a free communication with a cyftic dud, yet the bile is found continually defcending into the duode- num. That the quantity of the bile, fo dif- charged, is veryconfiderable, may appear from the bulk of the organ by which it is feparated, as well as the magnitude of its excretory dud, fo many times exceeding that of the falival glands j and from difeafes, in which the quan- tity of the cyfliic bile only has, by an ulcer of the fide, been let out equal to four ounces at once. • « §• 693. 202 Of the Liver. §. 693. The hepatic bile is always bitter, but the cyftic is more fo ; and both of them eafily mix, either with water, oil, or vinous fpirits, and are extremely well adapted to diflblve oily, refinous, or gummy fubftances. ’Tis in- clined to a putrefadtion ; but of itfelf, it naturally degenerates to a mulk-like odour. Its chemical analylis, and experiments of mixture with va- rious fubftances demonftrate, that it contains a large portion of water, but more than a fmall quantity of inflammable oil, equal to near a twelfth part, which, in ftones of a gall-bladder, appears very evidently ; befides which, there is no inconfiderable portion of a volatile alcaline fait. The bile, therefore, is a natural foap j but of that fort w'hich is made from a volatile faline lixivium. This, therefore, being inter- mixed with the aliment, reduced to a pulp, and flowly exprefled from the ftomach by the periftaltic force of the duodenum and preffureof the abdominal mufcles, incorporates them all to- gether ; and the acid or acefcent qualities of the food are in fomemeafure thus fubdued; the curd of milk is again diflblved by it into a liquid, and the whole mafs of aliment inclined more to a putrid alcalefcent difpofltion : like foap it diflblves the oil or fa% fo that it may freely incorporate with the watry parts, and make up an uniform mafs of chyle to enter the ladeals ; the furrounding mucus in the inteftines is hereby abfterged and attenuated, and their periftaltic motion is excited by its acrimony; all which offices are confirmed, by obfervlng the contrary effects from a want or defedt of the bile. Nor would the hepatic bile OJ the Li-oer. 203 bile of Itfelf be fufficient to excite the necef- fary motion of the inteftines, without the ftronger action of the cyfHc ; both which are of fo much ufe and importance to the animal, that we find, by experiment, even the ftrongeib will perifh in a few days, if the flux of bile be intercepted to the inteftines, by wounding the gall-bladder. §. 694. Thus it flowly defcends along with the alimentary mafs, and having fpent its force, or changed its bitternefs by putrefadlion, moft of it is afterwards excluded, together with the feces ; but probably fome of the more fubtle, watry, and lefs bitter parts are again taken up by the abforbing veins, which lead to the ports of the liver. It feldom returns up into the ftomach, becaufe of the afcent of the duode- num, which goes under the ftomach, with the refiftance it meets with from the valvula pylori, and the advancement of the new chyle, to which add the force of the contrading ftomach itfelf. The bile is, indeed, of a fv/eet foft nature in the foetus j for in them the feces are not very foetid, to fupply putrid alcaline vapours to the liver, nor are there any oily or fat lubftances ab- forbed from the inteftines. As the bile is a vifcid fluid, and thickens by inadivity of body in fat animals, and in us from the fame caufcs, efpecially when the blood moves languid from grief j fo it eafily coagulates into an hard, fome- what refinous, and often ftony fubftance, in- fomuch, that ftones of the gall are much more frequent than thofe of the urinary bladder. When the excietory paflages are obftruded by this 204 Liver. this caufe, or by a contrary convulfive motion in the dudts of the liver, the bile is, without much difficulty, urged again into the blood, which paffes the capillaries of the porta into the cava, as the way is fo pervious (§.682.); whence all the humours, and the mucous body of Mal- pihgi, become tindlured with its colour, which makes a jaundice. . Whether or no the com- mon biliary duft is ever truly inferted into the pylorus ? This, indeed, is an obfervation pub- lifhed in the more uncultivated ages of ana- tomy, the tradition of which has not been fa- voured by any of the more modern anatomifts ; although we fometimes read of its being in- ferted near to the pylorus. L EC^ 205 LECTURE XXVIII. • Of the Pancreas. §• ^ 95 ' \ ^ already feen, that the \\ bile is a kind of foap, but of a vifcid nature, and not fufficiently fluid to make a ready mixture, more efpecially in the cyftic bile j therefore nature has added to the bile a thin, watry, infipid liquor, called the pan- creatic juice^ which is neither acid nor lixivial, poured together with the bile into the inteftine, in the fame place, that it may dilute, improve, and incorporate with the bile by the perifl:altic motion of the inteftine, fo as to render the whole alimentary mafs uniformly mixed, and more apt to move forward ; at the fame time, it like wife, as a menftruum, dilutes the chyle, and produces the fame effedls which were before obferved of the faliva (§.604.), toge- ther with which, both in the confiftence of its juice, and fabric of the gland and its dud:, there is an exad agreement, as well as in the difeafes. That it alfo ferves to temperate the fharper cyftic bile, is alfo probable, and conformable to the obfervations of comparative anatomy 5 by which we learn, that, in thofe animals who have no gall-bladder, the pancreatic dud opens at a confiderable diftance from that of the bile. §. 696. The pancreas is then a very long glandule, the largeft of the falival kind, ex- tended tranfverfelv above the mefocolon, behind ¥ a 2 o 6 Of the Pa?2crea<. a produition of the peritonaeum, which, paf- iing over the pancreas, is here continued into the mefccolon j it lies partly behind the fto- mach, liver, and fpleen, before the left renal capfule and the aorta ; of a figure fomewhat like a trowel or long triangle, of which the upper edge is fmooth, and covered with the perito- na?um, upon which the pofterior flat fide of the empty flomach is fupported ; for that fide of the flomach is both lower as well as poflerior. The pancreas begins fmall from the fpleen it- felf, and, extending almofl: tranfverfely towards the right fide, it emerges forewards to the pe- ritonaeum acrofs the vertebra, to the right iide of w'hich it grows confiderably broad, wrapt up betwixt the fuperior and inferior plate of the tranfverfe mefocolon (§. 642.), and is finally fo connedted bv its round head to the duodenum, that this inteftine ferves it for a mefentery. The Ifrudfure of it is like that of the falival glands, made up by a great number of fmall bunches of a firm texture, connedted to each other by a good deal of cellular fubftance. The pancreatic blood- velTels are rather nume- rous than large, derived chiefly from the fple- nic branches ; but on the right fide it is fup- plied by the firfl; artery of the duodenum, and fi'om that which is in common both to the duodenum and pancreas, which lafl: both inof- calates wdth the former and with the mefenteric artery, and not onlv fuppli.es conlidcrable twigs to this gland, but likewife fmaller ramifications to the diaphragm and renal capfule. The nerves of this gland are not ot any confider- able of the Pancreas. 207 able fize j whence it is but little fenfible : they are derived from the pofterior gaftric and the hepatic plexus. §. 697. The excretory dudl of this gland runs almoft through its middle, white and ten- der, made up by a great number of lateral branches or roots, by which, being gradually increafed, it emerges before the vena portarum and mefenteric artery, and receives a large branch from the lateral pancreatic portion ; from whence it advances to the fame part of the duodenum, into which the biliary du6t opens, where, changing its courfe downward, it enters through the hnus, that lies betwixt the coats of the inteftine, internally fmooth ; and here, receiving the dudtus choledocus, it opens together with that (§. 686.). But not unfrequently it opens diftindl, both in its dud: and orifice, from that of the biliary dud j and fome- times it is inferred by two duds, of which the lower one only is diftind and lefs ; but they always open near or within a fmall compafs of the neighbouring dud of the bile. §. 698. The quantity of juice, fecreted by this gland, is uncertain j but it muft be very confiderable, if we compare the bulk or weight of it with that of the falival glands \ than which it is three times larger, and feated in a warmer place. ’Tis expelled by the force of the cir- culating juices, with an alternate prefiure from the incumbent and furrounding vifcera ; as the liver, ftomach, fpleen, mefenteric and fplenic arteries, with the aorta. The great ufefulnel's of this gland may appear from its being found I not 2 o 8 Of the Pancreas, not only in man, but almoft in all animals j nor is its ufe the lefs from that experiment, which lliows a great part of it may be cut out from a brute animal, unattended with fatality 5 for, by that rule, the animal, furviving after a part of the lungs are cut out, would render them equally ufelefs, and befides, in the expe- riment, a part of the pancreas muft be left with the duodenum. As to this juice making any effervefcence with that of the bile, the notion has been fo long exploded, as to need no further notice. LEG- LECTURE XXIX. Of the fmall Intefines, 7C0. Y. the fmall intehines, anatomifls underftand one continuedj almoft equal or cylindrical tube, whofe tranfverfe fedlion is nearly oval ; the acute end being towards the unconnedled fide of the inteftine. This tube is continued from the end of the ftomach, which it embraces (§. 624.), through a long folded tradt, down to a rhuch larger inteifine, the colon. Anatomifls have ufually reckoned three fmall inteliines, though nature has formed but one* However, the duodenum has gene- rally pretty certain bounds, terminating with its end in that part of the abdomen, which is above the tranfverfe mefocolon (§. 642.). But the fmall intefiine which lies below this me- focolon, commonly called i\\Q jejunum^ has no certain mark or boundary, to feparate it from the lower portion, -which is commonly called the ilium : although the former, abounding more with valves and blood-veffels, has, in ge- neral, a more florid appearance, and is fur- nifhed with longer villi internally ; and the ilium again, having fewer of thofe vafcular ra- mifications, like little trees, abounds more with a fort of minute glandules 5 however, thefe differences infenfibly difappear one in another, without afiording any certain limits betwixt the two inteftines. VoL. II. P §• 2 10 Of the hiiejlines. §, 701. The duodenum feems to be deno- minated from its length, meafured by the breadth of the fingers. It is larger, and more lax or open than the other fmall intefiines, more ef- pecially in its firfi; flexures ; which is partly owing to its not being circumfcribed in fome places with any external membrane, and in other places only for a fmall compafs. It is florid and tender, having its flefhy fibres, fome- times of a confiderable thicknefs. Its origina- tion begins round the ring-like valve at the mouth of the pylorus ; from whence it is un- dulated or infleded, but in a tranfverfe courfe, to the right downward in an empty ftomach, under the gall bladder, to the neck of which it is contiguous (§. 691.). From the gall- bladder, it defcends obliquely to the right fide, as far as the lower plate of the mefocolon, where it is perforated by the biliary dudt (§.698 ), and, in its courfe, is intercepted betwixt the upper and lower plate of the mefocolon, thro’ which it proceeds, at length, tranfverfely, but a little afcending behind the pancreas and large mefenteric veflels, and goes on to the left fide along with the left renal vein, where, going out from the dup’icature of the mefocolon, it bends round, before and to the right of the faid veflels, and pafles through a peculiar foramen, in which the mefentery and left part of the tranf- verfe mefocolon adhere to the inteftine itfelfj from thence it defcends forward, towards the lower part of the abdomen, into which it ad- vances, under the denomination of the jejunum. The largenefs of this intefline, with its alcent Of the Intefi?ies. 2 1 1 from the Infertion of the biliary dud:, joined with the confequent fold about the root of the mefentery, caufe a remora of its contents, by which the bile, pancreatic juice, and ali- mentary pulp, are here firfl intimately blended together. §.702. The reft of the fmall inteftine, hav- ing no certain feat or divifion, is continued by innumerable and uncertain convolutions, not tq be defcribed, fo as to fill out the lower part of the abdomen and pelvis, furrounded . by the colon on each fide, and fuftained by the bladder and uterus below. §. 703. The fabric of the fmall inteftine is almoft ti.e fame wdth that of the ftomach and oefophagus. Its external coat, excepting part of the duodenum, is received from the perito- nteum or mefentery, applied on each fiae to the obtufeendof the oval inteiline, and feparated by the intervening cellular fubftance, which is often replenifhed with fat, but more clofely embraces or adheres to the mufcular fibres in the unconneded hde of the inteftine ; wTere, the outer and mufcular coat imidly cohere, without fhowing any remarkable difference from what we have obferved of them in the ftomach (§. 622.}. By this external membrane, continued with the mefentery (§. 634.), the inte:'ines are fupported, with a confiderable degree of firmnefs, at the fame time that they are allowed every way a free liberty for mo- tion. §. 704. But the fabric of the mufcular coat differs from that of the ftomach, in the figure } s> P 2 of 2 1 2 Of the Intefmes. of its fibres. The largefl and moft confider* able body of thefe fibres are circular, cloath- ing the tube on each fide, refembling each other, both in their parallel difpofition and ap- pearance, which is that of imperfedt arches or fegments of circles, cemented one to ano- ther, paler than other mufcular fibres, and yet contraftile with a confiderable ftrength. The longitudinal fibres are, in the fmall inteftines, much fewer in number, fcattered round their whole extent, interfperfed with the former, and are more efpecially fpread upon the loofe or Linconnecfted fide of the intefline. §. 705. Within the mufcular coat, is feated the fecond cellular, of a larger or loofer extent here, as it was in the fiomach ; and this being fpread on all fides round the nervous coat, which it includes, is, in us, feldom replenifhed with fat. But the nervous coat, being like that of the fiomach, ferves as an internal foundation or fuppcrt to the whole inteftinal tube ; being compofed chiefly of compared fibres, which, by inflation, may be parted one from another, fo as to refemble a web-like or cellular fub- fiance. Next to this, follows the third cellular coat, which is almofl: like the fecond ; and then the innermofl; or villous coat, which differs, in feveral rerpedls, from that of the fiomach : for fiiTt it is folded on all fides into wrinkles, that are femicircular, the extremities of which correfpond one to another oppofitelv, but uncertain in their proportions ; into which wrinkles, the nervous coat enters in fome de- gree, while the red of the intermediate fpace, betwixt Of the I?2teJUne^.. 213 betwixt the folds of the villous tunic, is filled up by the third cellular ftratum. Thefe plies or folds of the inteftine begin within one inch of the pylorus, and are moft frequent or numerous in the anterior or , loofe part of their middle tradt, but grow fewer in number downward. Here each fmall twig of the ar- tery, which is fpread in the cellular fubfiance, upon the convexity of the inteftine on one fide, is anfwered by another twig, difpofed in the fame manner, on the oppofite fide. The plies are, at firft, confufed in the duodenum, and- afterwards become more confpicuous, as the inteftine advances ; but the appearance of acute imperfedl circles or valves is given to them by anatomical artifice or preparation, in which their natural ftate is altered j for thus they are very foft, and eafily fludluate on ail fides, fo as to give way, in any diredlion, to the courfe of the alimentary pulp, upon which, however, their number has fufticient influence to retard the motion^ while, at the fame time, they con- fiderably enlarge the extent of the abforbing villous coat. §. 706. We come now to the true villous coat, which we call fo in other parts, by ana- logy, frorn this, in Vv^hich the fabric is moft: remarkable or confpicuous j namely, the w'hole internal furface of the inteftine and its valves, together with the fmall cavities, interpofed be- twixt them, fend out, on all fides, innume- rable fmall fludluating fleeces, like a piece of velvet or clofe frieze, the extremities of which ' ^re obtufely conical produdtions of the inner P 3 coat 214- Of lie IntCj Tines. ^oat of the inteftine, formed by the Intercepted Cellular fubftance, in which fmall nerves and blood-velTels are wraped together, fo as very much to refemble the papilla of the tongue, only of a fofter texture. §. 707. In the furface of this internal villous coat, open an infinite number of pores ; fome larger, others fmaller. The former lead to fmall confpicuous fimple glandules of the mucous kind, feated in the fecond cellular lira- turn, and like to thofe of the vafcular follicles, feated in the mouth and pharynx, which like- wife open with numerous patulent orifices into the inteftines. In the duodenum thefe are af- fembled together in feveral places, without meeting one into the other, which they always obferve ; but many of them are quite folitary or afunder in the ilium, or often afiembled only a few together, though, in many places, a con- ' fiderable number of the fame kind are afiem- bled together, into a little army of an elliptical figure. §. 708. Throughout the wdiole tradl of the intefiines, are found pores of a lefs kind, fur- rounding the bafis of the villi, and mofi: ample or confpicuous in the large intefiines, where they were firfi; obftrved ; but have been lately difeovered, by a more careful inquiry, in the fmall intefiines likewife. Thefe alfo feem to depofite a liquor of the mucous kind. §. 709. The veffels of the fmall inteftines are very numerous. The comnron larger trunk belonging to the intefiine that occupies the fpace below the mefocolon, is called the mefen- teric Of the Infefina. 215 teric artery, being the largeft of thofe produced by the aorta above the renal arteries ; and this, defcending behind the pancreas to the right fide of the jejunum, and before the colic branches, fends out more efpecially a long trunk to the bottom of the mefentery, and termination of the ilium towards the right fide, as on the left fide it fends out numerous branches, which, being longeft in the middle, are continued fhorter each way, like the flicks of a fan. Thefe laft, fubdividing into fmaller, form in- ofculations betwixt each other, in fiaape of an arch, which again fend out other branches, repeated, in like manner, to about the fifth fubdivifion, where, forming their laft convex- ity, their numerous fmall branches are detached on each fide the inteftine. §. 710. The divifion of thefe branches is much after the fame regular manner, fo that one comes out from the mefentery, through the cellular fubftance, on the forefide of the inte- fline, as the other does, in the like manner, upon the lower fide j and after fpreading them- felves upon the mufcular coat, their fmaller circling ramifications penetrate through into the fecond cellular firatum j there the ante- rior capillaries, advancing towards the outer apex or loofe margin of the intefiine, form in- ofculations diredly with thofe of its oppofite, gradually fpreading and detaching fmaller (hrub-like twigs, inofculating with each other, and with their oppofites, by innumerable circles. From this arterial net-work, fmaller twigs pe- netrate, from the nervous tunic, into the third P 4 cel- 2 1 6 Of the Intef tries, cellular ftratum, and are, with that, continued to the ultimate extremities of the villi, where they, at laft, open by exhaling orifices, and difcharge a watry hummur into the inteftine ; for this continued courfe is eafilv imitated and fhown, by injedting water, fifh-glue, or mer- cury. But late induftry has diicovered, that theie arterial extremities firft open into an hol- lov/veficlej from whence their depofited juice flows out through one common orifice. For the reft, the arteries in this part, form nu- merous reticular inofculations, that, by avoiding all obftrudions, tliey may be able to fupply the inteftines equally on all fides, and that any ob- ftrudting matter may, upon occafion, be eafily removed back from the narrower extremities to the larger arterial trunks. §. 7 1 1. The laft mefenteric trunk or artery inofculates with the ilio-colic. The duodenum has various arteries. The firft and uppermoft to the right fide goes round to the convexity of the inflexure of this inteftine, which it fupplies in its way to the pancreas, and inof- culates together with the lower or left pan- creatico-duodenal artery, which makes a like arch round the curvature of the duodenum into the pancreas, being, at laft, inierted into the lower duodenal arteries, produced by the me- fenteric, in its paflTage before this inteftine. As to the fmall arteries, which go from the fpcr- matics to the duodenum, and from thofe of the renal capfule, we defignedly omit any fur-. ■ ther notice of them, §-7n. Of the I/.ieJlines. 2 iy ^.712. The mefentcric veins meet all to2:e- ther, in the lame courfe or dilpofition with the arteries, into the mefenteric trunk of the vena portarum, except the right duodenal vein, which goes immediately into the trunk of the vena portaruin itfelf, and except thofe fmall veins, which run in company with the preceding fmall arteries (§. 611.), and are inferted into the fpermatics and lumbals.- Nor have 1 been able to difcover any other veins of the mefentery, arlling from the cava. It is a property, in common, to all thefe veins to be without valves, and to make free communications with the ar- teries. Thofe veins in the villous coat, which is, for the molt parfr, compofed of veins, ab- forb thin humours from the intefline, as appears from the injedlion of watry liquors, whicli readily run through the fame way ; and, from analogy, in aged perfons, in whom the me- fenteric glands, and conf;quently the ladteals that pafs through them, are frequently clofed up 5 add to this, that birds have no ladeal velTels, and the celerity with which watry liquors pafs to the blood and through the kid- neys, compared with the fmallnefs of the tho- racic dudt, feem to make it evident, that a large part of them enters the blood immediately, by the mefenteric veins. §. 713. The nerves of the mefentery, tho’ fmall, are numerous, whence the inteftines re- ceive no little degree of lenlibility j they arife from the middle plexus of the fplenic nerves, and, embracing the mefenteric artery, play round it in great numbers, wraped up in a very denfe 2i8 Of the I', t fines. denfe cellular plate. The duodenum has like- wife fmall nerves from the pofterior hepatic plexus of the eighth pair. §.714. From the exhaling arteries diilils a thin watry liquor into the cavity of the inte- flines, not at all acid, but like the juice* of the flomachj the quantity of which liquor may be computed from the large extent or fum of all the excretory orifices, and from the fedion or light of tlie fecretory artery, larger than which, we fee no where in the body ; add to this, the laxity of the parts, perpetually kept warm and moift, and the copious diarrhoea or watry difcharge, that often follows the ufe of purgative medicines. Bift the mucus, arifing from the pores or cells before mentioned (§. 707 and 708.), ferves to lubricate and defend the internal furface of the villous membrane, and to guard the fenfible nerves, from ftrongly acrid or pungent particles. Hence we fee, it is more abundant at the beginning of the larger inteftines, becaufe there the mafs of aliment begins to be more feculent, acrid, and tena- cious. §. 715. The mixture of this liquor with the pulp-like mafs of the aliment, together with the bile and pancreatic juice, is made by the motion of the furrounding mufcles of the ab- domen, but more efpecially by the pet ifialtic motieny which is more particularly llrong and evident in the fmall inteflines. For any part of the inteftine, irritated by fiatus or any fearp or rough body, contrads itfelf, even after death, with a confiderable force, in that part w^here Of the Inteflne’. 219 the fcimulus 5 s applied, in order to free itfelf from the offending or diftending body, which it expels into the next open part of the lax in- tefHne; where, being received, it is again pro- pelled forward, by exciting a like ftimulus and contradlion as before. This contrading mo- tion of the inteftine is made in various parts of the gut, either fucceflively or at the fame time, wherever the flatus or aliment excite a Ibimu- lus ; and this, without obferving any certain order, with a fort of wonderful alternate creep- ing and revolution of the inteftines, as appears eafily from the diffedion of living brutes, and fometimes by unhappy accidents in our own fpecies, as in ruptures and wounds in the ab- domen, ^cc. [This creeping of the guts, for facility and duration, is equal, if not fuperior, to the irritability of the heart itfelf, §. j 14.] And fince here, among fo many inflexions, the weight of the aliment is but of little force, it eafily afcends or defcends through the irritated intdbine, which thus empties itfelf. From hence, the ufe of the pcriftaltic motion is in- telligible, by which the pulp of the alimentary mafs is oftener or longer applied with a gentle force to the triture of the intefline, to the exha- ling diluent liquor, and to the mouths of the ablbrbing veins. But all the contents of the intefline are determined downward to the co- lon, becaufe the flimulus begins above, from the left opening of the flomach; and fo, by the fucceffion of new chyle, repeating the flimulus above the contradion, it defcends, when there is no tefiflance made to it, into the lower parr 220 Of the Tntefines. of the ilium, at its opening into the colon j here the loofe part of this inteftine readily re- ceives what is preffed into it by the contraction from above, and as eafily unloads itfelf into the large unadtive cscum j from whence it is again repelled upward, and, in part, urged on by the preffure of the lucceeding mafs. Anato- mifts dbferve, that this motion is made ftronger downward than upward. §.716. This periftaltic motion of the inte- ftines is perform.ed by the conftridion of their circular fibres, which exadtly know how to empty the tube, without injuring the inteftine againft pins, needles, or any other ft:iarp bo- bies lodged within their contents, which they tenderly promote forward. But the revolutions of the intefiines, drawn upward and downward, and the ftraightening of crooked parts of them one before another, which is fo remarkably con- fpicuous in brute animals, are performed by the long, fibres, which we fee contract themfelves at the feat of the prefent ftimulus, and dilate the following portion of them, to receive what enfues. By the fame contradHon, the villous membrane of the inteftines, within their ca- vity, is urged and reduced into longer folds ; whence the mucus is exprelfed and applied to that part of the alimentary mafs, where it was required by the force of irritation and ftimulus. Thefe long fibres frequently make intro-faf- ceptions of the inteftines, and generally with- out any bad confequences, by drawing up the loofe portion of the inteftine into that which ^ contradled, in fuch a manner, that the loofe I portion i Of the Intejiines, 221 portion is furroimded by the other, which is contradled. §.717. The alimentary pulp, therefore, di- luted with the pancreatic juice and that of the inteftines, intimately mixed with the fapo- naceous bile and circumjacent mucus, is fo more perfedtly diflblve.d than by the efficacy of the ftomach, in proportion as the hdes of the in- teftines come into a larger contadl, and ap- proach nearer together; to which add, the longer feries of the periftaltic motions, and the greater quantity of diffolving juices. In this manner, the alimentary pulp, intermixed with air, forms a froth, without anv kind of fer- mentation, which air is the fame with what we commonly eructate from the ftomach j but yet, at the fame time, the acid or acefcent force is fubdued, while the oily or fat parts dif- folve by the'bile (§. 69 intermix with the wa- try juices, and put on the chyme its ufual milky appearance, like an emulfton, of a bright colour in the duodenum, at the firft entrance of the biliary duCt ; from whence downward it clofely adheres to the villous coat of the fmall inte- ftines. But the gelatinous juices of flefh meats, diluted with a large portion of water, do more particularly adhere to the villous coat, and en- ter it in the way of abforption. So water and watry liquors are all very greedily drank up by the veins, and yet the farculent remains never grow thick in the fmall intellines, as far as. I have been able to obferve ; becaufe the ■ watry part is repaired by the arterial vapour arid mucus j nor do -hey become foetid in any 2 ‘ confi- 222 Of the Intefines. confiderable degree, as well becaufe of the great quantity of diluting juices, as becaule the quick progreffion will not allow them time enough for a putrefaction. Chyme is cf a white colour in the beginning of the jejunum, but is altogether mucous in the end of the ilium. Thofe remains, which are of a more earthy, grofs, and tough or acrid difpofition, which were excluded by the mouths of the abforb- ing ladteal orifices, do, by their weight or by the mufcular contractions, defcend flowdy into the large inteflines, fo as to complete their whole courfe in the fpace of about tu'enty- foLir hours. But within three, four, five, or fix hours time, all the chyle or ladeal juice of the aliment is commonly extracted from the fmall inteflines. §. 718. The confiderable length of the fmall inteftine, which is five or more times longer than that of the body, the great furface of the villous membrane increafed by folds, the in- credible number of exhaling or abforbing vef- fels, the flow courfe of wdiat remains through the large inteflines, and the great quantity of the intellinal juice, poured into the alimentary ma!s, do all of them concur, in the fmall in- tefline, abundantly to perfc^rm what is required in the emulfions of the food for our healthy juices, and for their abforption into the ladfeals and the mefenteric veins ; alfo tor abllerlion of vifcidities from the ii.telline, for the avoid- ing adhefions and coagulations, and for the fubduing any venomous or flrong quality in many juices, which, being directly mixed with the blcod. Of the Inteflines. 223 blood, inftantly kill^ but are thus fent in by the mouth without damage. Hence, in general, the inteflines are long in animals, that feed upon any hard diet, but fhorter in carnivorous ones, and fhortefl in all thofe that live upon juices ; and, even in man, an uncommon fhort- nefs of the inteflines has been known to be at- tended with hungrynefs, and a flux, or a dif- charge of feetid and fluid feces. • < LEC- LECTURE XXX. Cf the chylijerous Vejfeh, §• 7 ^ 9 * ^ I ' H E chyle is a white oily juice" extradled from the aliments (§. 717.), which is afterwards poured into the bk)od. That its principal compofition is of water and oil, feems evident, from the fweet- nefs of its tafte, from the w^hitnefs of its co- lour, and from its fpontaneous acefcent nature ; in all which it refembles an emulfion. It feems to be compofed of a vegetable farina, with animal lymph and oil ; w^hende, with a little alteration, it changes into milk. But af- terwards it becomes more manifeftly glutinous ; lince the pellucid ferum it contains, either by exhaling the watry part, or by applying an in- tenfe heat, coagulates into a kind of hard jelly, lefs firm than an egg. §. 720. That the chyle is abforbed into the ladteal veffels, by the adhering villous coat, has been a long time known, by experiments of injecff- ing tindfured liquors, which readily defcribe the fame courfe ; and from the white liquor of the ladleals, let out from blood -veflels, with the ve- nal nature of them. But late experiments have taught us this, in a much better manner. The chyle is abforbed by a fmall opening in the ex- tremity of each of the villi, by the fame force which is common to all capillary tubes, by which it is taken up into the cavity of the ab- forbing Chyliferotn Vejfets, 2 2 5 forbing dii£t, at the time v/hen the intefline is i'elaxed ; but the veficle, by which the abforb- ing dudt begins in the inteftine, being prelTed by the facceeding conftridiion of the mufcular fibres in the periftaltic motion, urges the con- tents further on into the dudt, which begins to appear within the fecond cellular firatum. But there is a two-fold ftratum of thefe abforbinsf veffels, one anterior, the other pofterior, as we obferved before of the blood-vefiels (§-709). From thence, uniting into a larger canal in the firfl cellular ftratum, the abforbed liquor enters into the ladteal veffels, which, in general, fol- low the courfe of the arteries, only loofe, and without circles or arches, but conjoined into an obliquely angled net- work. They are fur- nifhed with valves, as foon as ever they are paffed the inteftine, like thofe of the lympha- tics, joined together by pairs, of a femilunar figure (§. 52.), which admit the chyle, pafling from the inteftines, but prevent its return, and fuf- tain its weight. Through this whole courfe, the chyle is urged on by the periftaltic motion of the inteftines, as well as by the contradlile force of the veffels themfelves, which, even after deathj is ftrong enough to propel the chyle ; to which add, the confiderable preffure of the abdominal mufcles and other parts, de- termined by the valves* The greateft num- ber of thefe lafteals arife from the fore-part of the fmali inteftine, below the mefocolon, fome from the duodenum, and a few from the large inteftines themfelves. , ; VoL. II. §*721, 226 ChjUferous VeJfeU. §. 721. But betwixt the plates of the me- fentery, at the divihonsof the veffels, are found an infinite number of fmall conglobate glan- dules (§. 182.), but fomewhat fofter and more fpungy, owing to a greater turgefcence with cellular juices, alfo from the external mem- brane being lefs hard than in other parts, and from their being painted with numberlefs fmall blood-vefiTels. Into one of thefe glandules, en- ters a ladleal vefiel, where, fubdividing into branches, it pours out the chyle into the cel- lular fabric of the gland ; from thence again it is prelTed by the contradtion of the vefiels, but more efpecially that of the abdominal muf- cle'^, by which the chymous emulfion, entering the ladleal vefibl, is drove on fucceffively to two or three other glands of the like kind, and pafibs by others, in the way, without entering into them. But that this is the true courfe of the chyle, by which it pafles from the inte- ftines to the mefenteric glands, appears from a ligature by thevefiel, growing turgid betwdxt the faid ligature and the intefiine ; and from fchir- rhofities in the glands, by which they are ren- dered more confpicuous ; and from the nature of the valves themfelves hindering any re- turn back to the intefiines. 722. What alteration the chyle under- goes witlf n the cellular fabric of thefe glands, is not yet fufiicie«tly known ; but it appears, in general, that fome thin liquor difiils from the arteries in this part, ferving to dilute the chyle, into which it is poured. For it is ob- fcrved, that after the chyle has furmounted all Chyliferom Vejfeh, 22 J the glandsj it appears more watry ; and thin liquors, injedted through the arteries, pafs out into the cellular fabric of the glands, and mix with the chyle. §, 723. From the laft glandules, which are collefted together in the center of the mefen- tery, the ladteal veffels go out very large, and few, to the number of four, five, or more, which afcend together with the mefenteric ar- tery, and intermix with the lymphatic plexus, that afcends from all the lower parts of the body, creeps over the renal vein, and then goes, with this and the hepatics, behind the aorta, to the lumbal glandules. Here the lymphatics take a variable courfe, but moil frequently terminate in a veficle of confiderable breadth, at the fide of the aorta, betwixt that and the right appendix of the diaphragm ; there it ufually appears fomewhat turgid, two or more inches long, and often afcends above the diaphragm into the thorax, conical both above and below; his called the receptacle of the chyle, in which the gelatinous lymph of the lower limbs, and of the abdominal vifcera, mixes with the chyle, and dilutes its white colour. But there are fome iuftances, where there are only two or three fmall, and fomewhat angular dudls, inftead of this receptacle or ciftern of the chyle; which, ho .vever, generally fpeaking, is to be found in mod fubjeds, and fuffers a confiderable alter- nate preffure from the diaphragm and aorta, by which the chyle is moved fafter through it, in proportion, as the light of the ciftern is 0^2 greater 228 Chyltferoiis VeJJeh. greater than that of the thoracic dud, into which it empties itfelf. §. 724. The thoracic dud, as it is called from its courfe, is generally Angle, or, if it be double for fome part of its courfe, it foon after unites into one again, which goes behind the pleura, betwixt the vena azygos and the aorta j and, afeending in an infleded courfe, it receives, in its way, the lymphatic veffels of the ftomach, cefophagus, and lungs, and paffes through the dorfal glands, of which there are many incum- bent on and about it. It is, in general, cy- lindrical, and often forms iiifulations, by fplit- ing or dividing into two or more ; after which it unites into one again, more efpecially in its upper part. It has few valves, and thofe not very confpicuous. About the fifth vertebra of the back, it generally crofies behind the cefo- phagus, and then afeends along the right fide of the thorax, behind the fubclavnan blood- veflels, ’till it has arrived near the fixth verte- bra of the neck. §. 725. There, bendingdown, it often divides Intotwo, and each defeending branch dilates into a fort of veficle that enters, either with di- ftindl or united openings, into the jundlure of the fubclavian and jugular vein internail v, by an oblique courfe from the upper, pofterior, and lateral part downward towards the left, and forward, going either with one or with two branches under the fubclavian, on the outer fide of its jundlure with the jugular. It has no true valve placed before it 3 but excludes the entrance of the blood, only by the perpendi- cular Chyliferous Vejfeh. 229 cular weight pf its contents. But the oblique infertion of it reprefents a fort of wrinkle. It is rarely otherwife difpofed, and more rarely fplit into two, length-wife, for diftindl infertions into the fubclavianj and yet more rarely apt to fend off a branch into the vena azygos. Near its infertion it receives the opening of a large lymphatic veffel, tranfverfely from the arm, and another defcending from the head, in one or more trunks. §.726. The chyle, mixed with the blood, does not immediately change its nature ; as we learn from the milk, which is afterwards made of it. But after five, or more hours have pafied from the meal, almoft to the twelfth hour, during all which fpace, a woman will afford milk ; after it has circulated near 80,000 times through the body, fomented with heat, and mixed with a variety of animal juices, it is, at length, fo changed, that a part of it is depo- fited into the cellular fubftance, under the de- nomination of fat ; a part of it is again con- figured into the red blood-globules (§. 165.)} ano- ther part, that is of a mucousor gelatinous nature, changes into ferum ; and the watry parts go off, in fome meafure, by urine, in fome mea- fure exhaled by perfpiration, while a fmall part is retained in the habit, to’ dilute the blood. Nor is it any thing uncommon for a pellucid lymphatic liquor to fill the ladleals, in a dying animal, inftead of chyle j or for fome of them to appear milky in one part of the mefentery, and limpid or pellucid in another : fince, both as to their fabric and ufe, they alfo agree to anfwer Qj the 230 Chyliferom VelJeh. the end of lymphatics. There are not, there- fore, two kinds of veffels from die inteftines ; one to carry the chyle only, and another pecu- liarly for the conveyance of lymph. §. 727. After the digeftion has been corn- pleated fome time, the ladeal veflels abforb pellucid watry juices from the inteftines, whence they appear themfelves diaphanous ; but the thoracic dud is more efpecially a lym- phatic of the largeft order, conveying all the lymph of the abdomen, lower extremities, and moft parts of the body to the blood (§• 51-) LEC- 231 LECTURE XXXI. Of the large Intefmes. §. 728.‘¥TTHAT remains, after the chyle VV abflraded, confifts of fome portion of the bile and inteftinal mucus, but both depraved in their nature j fome part of the human mucilages, mod; of the earthy parts that were lodged in the food, and all thofe parts, which, by their acrimony, were rejecled by the abforbing mouths of the lac- teals (§. 717.), with all the folid fibres and membranes, whofe cohefion was too great to be overcome by the maceration and periftaltic motion in the inteftines. §,729. All thefe remains pafs from the ex- tremity of the ilium into the cascum, in which they are colleiled and fiagnate; namely, the extremity of the fmall inteftine, called the ilium, applies itfelf obliquely, in fuch a man- ner, to the right fide of the colon, refting upon the right ilium and its mufcle, that, in gene- ral, it afeends in a curve, but more in its lower fide, and lefs in its upper, which is almofi; tranfverfe. But finally, the nervous and vil- lous parts of the ilium are fo extended, be- twixt the departing fibres of the mufcular and nervous coat of the colon, as to hang pendu- lous within the cavity of this large inteftine, with a double eminent wrinkle or foft fold, compofed of the villous and nervous coat of 0^4 the 2^2 Of the htejllnei. the thick inteftine, and of the fmall intedine likewife, joined together by a good deal of tlie cellular fubflance, The upper tranfverfe fold is fliorter, as the lower is broader and more af- cending, being conjoined together by a fmall production of the fame kind, more efpecially in the right fide, adjacent to them. Betwixt thefe two folds, the mouth of the ilium opens, like a tranfverfe flit. But when this intefline is inflated and dried, the ftruclure of it changes very much, reprefenting thefe parts to us, under the figure of m-cmbranes and hard valves. After the cellular plate has been entirely removed from them, the ilium comes clean out from the colon, and the valvular appearance is no more to be feen ; but if a large part of it only be drawn out, leaving a fmall portion in- ferted behind, it refembles a fphinCter. §.730. Below the entrance of the ilium, at the diflance of fome inches, the great intefline defcends and forms a blind or impervious ex- tremity, called the C(^cum^ refling upon the ilium. From the lower part of this, towards the right fide, extends a fmall worm-like pro- cefs, in adults of confiderable length, like a iongly extended cone or little intefline, varioufly incurvated, fometimes downward, and full of fmall mucous glands, which pour out a gluey mucilage to the feces ; but, in the fetus, the colon i:fe1f is extended into a conical appen- dix. But the weight of the fuperincumbent fasces, deprefling the fpace on the riglit fide of the appendix, is the caufe of its gradually re- ceding from the extremity of the colon, When,- there-= Of the Intejlines. 233 therefore, the remains of the alimentary mafs are fent from the ilium into the colon, they fall by their Vs^eight iirft into, the cavity of the csBCum, or impervious bag-like appendix j here, by ftagnating, and the warmth of the parts, they begin to putrify, according to their par- ticular nature 3 and thus is introduced the foetid fmell, obfervable in the excrements. §, 731. The colon is an inteftine altogether continuous, as one and the fame with the former ctecum 3 namely, the largeft of the great inteftines, and by much the ftrongeft : beginning upon the ilium (§. 729.), it afcends over the right kidney, and lies under the liver, with an angle in the right hypochondrium ; beino- conneded to the vifcera, on each fide, by the peritonaeum. From thence it paffes under the liver and ftomach, for the mod: part, tranfverfely to the fpleen, under which it is bent in fuch a manner, as often to form an angle with itfelf 3 from whence it defcends deeply under the left ribs (§. 660.). . From thence again, continuing its defcent to the left ilium, it forms a large flexure inwardly to the pelvis (§. 641.) ; from which flexure it is con- tinued, in its lower part, through the pelvis, under the denomination of redum. §. 732. The flrudure of the colon is in ge- neral the fame with that of the fmall intefrines, but it has feveral things peculiarly differing from them : and firfl, the longitudinal fibres are colleded together into three bundles or tapes, commonly called ligaments, which run through the whole extent of the intefline 3 and of 234 Q/' Intejiine^. of thefe one lies naked, the other is covered by the omentum j and the third is contained in the mefocolon. Thefe ligaments, which ad- here firft to the dilatation of the vermiform ap- pendix, being much fliorter than the inteftine, the latter is by their cohefion drawn together, fo as to form its membranes into protuberant wrinkles in the parts which lie betwixt the li- gaments ; more efpecially at the mefocolon is feated the firft cellular ftratum, replenifhed with fat. There are often only two ligaments in the extremity of the colon, where the two leffer join into one. §. 733. Again, the nervous coat, and third cellular flratum, with the villous tunic of the colon, are extended into much larger wrinkles, in the parts betwixt the ligaments, often pro- jedl'ing in a three-fold rank, fuflained by the ligaments, that they may be able to refilf and fupport any fliock or prelfure from the motion of the feces. In the beginning of the colon, they obferve their three-fold order, exadtly enough, at regular didances ; but in their pro- grefs, they vary more by degrees, being lefs, fometimes double, often folitary, fmall and large intermixed, or none at all. Where the liga- ments which contradt the colon difappear, thefe valves almofl difappear entirely. Ladly, the villous coat is thinner, without villi, but porous and wrinkled, furnifeed as well with large pe- culiar pores of its own, leading to round folicles or cells, which are folitary, as well as innu- merable fmall pores, leading to fmaller follicles, both which fupply a great q^uantity of mucus. Of the Tntefines. 235 §. 734. The blood velTels of the large in- teftines, from the mefenterics, are of two kinds. Firfl, the middle colic artery arifes from the large mefenteric trunk, as that defcends behind the tranfverfe mefocolon, where it arifes up with one, two, and fometimes three branches, go- ing to the right fide with the ilio- colic, and to the left, where, with the lower mefenteric, it meets it in a very large arch, which makes the mofi; confiderable arterial inofculation in the whole body. Again, under the mefocolon, from the fame large mefenteric artery, arifes a confiderable branch that goes diredtly to the fold of the ilium with the colon, and upw^ard to the right colon ; but to the left it runs toge- ther wdth the mefenteric, out of the middle of which it gives a branch that runs along the worm-like appendix of the mefocolon, and ter- minates itfelf in both the anterior and pofterior fold, by which the ilium is inferted into the colon. Laftly, the lower mefenteric, arifing by its proper trunk from the aorta, betwixt its bi- furcation and the renal arteries, goes to the left colon ; above, it runs by a large arch, toge- ther with the middle colic, and being bent downward in three or four trunks, it fpreads over the flexure of the colon, and defcends even into the redlum. Finally, the lower me- fenteric, goes out by a proper trunk from the aorta, betwixt its bifurcation, above the os fa- crum and the renal arteries, whence it is difiri- buted to the left colon ; but it runs up by a large arch with the middle colic, and bending down in three or four trunks, fpreads over the iliac flexure 236 Of the Intejlines. of the colon, and defcends even into the redlum. Here the rcdum receives various branches from the middle hemorrhoidal, ariling from the laft trunk of the hypogaftrics, and conjoined with the former. The ultimate arteries are from the fame trunk, but diftributed without the pelvis. V/e negled here the fmaller colics, ariling from the fperrnatlcs, intercoibal, omental, capfulary, and lumbal arteries. The veins, taking the fame courfe with the arteries, run together into the gaftrocolic, and the hemorrhoidal, which laft is either Internal, middle, or external. §. 735. The divifion of the velfels to the large inteftines, difters from that of the fmall inteftincs. The arches the trunks lend off are neither fo frequent nor fo often fub- divided ; th^y run further entire upon the inteftinal tube, accompanied with fewer glands, and their branches are diftributed not fo much like trees, andform fewer net- works in the cellu- lar fubftance ; but they diftil an exhaling moifture into the cavity of the inteftines, as the veins likewife abforb a thin foetid vapour from the feces. §. 736. But there are alfo lymphatic veffels, ariling from the whole trad! of the colon and redlum, which conjoin with thofe of the loins. We are not without examples of the chyle en- tering thefe lymphatics from the colon, inftead of lymph, which is an argument that they are of fome further ufe in this part, by conveying nourilhment to the blood. From hence is the cdicacy of nourilhing glyfters, and thofe ufed in fevers. Of the InteiTifies, 237 fevers, which pafs by thefe into the blood, often very readily. §. 737. The nerves of the large inteftines are from the plexus, compofed by the defcending branches of each renal plexus, and others ariiing from the intercoftal trunk of the thorax and loins, with others produced from the large me- fenteric plexus. Thefe nerves accompany the lower mefenteric artery, and pafs with them to the colon. The lowermoft nerves arife from the left colic plexus, before mentioned, from whence they go to the redlum, within the pel- vis; others are from the lower intercodals, and the nerves of the facrum, which terminate like- wife in the reftum. Thefe nerves are of the fmaller kind, which renders the inteftine lefs fenfible, that it might better fuftain the preffure of the hard and acrid fasces. §.738. The inteftinal feces, therefore, re- tained in the blind beginning of the colon or large inteftine (§. 729.), there grow dry by the abforption of moift vapours, fo as to be ca- pable of receiving a figure from the round con- traded parts of the colon, by w^hich being fuf- tained as on a ftair-cafe, they afcend from the bottom of the c$cum, elevated by the long li- gaments, which end in the worm-like appen- dix. And here we are more eafily capable of perceiving the manner, in which the feces are propelled, by the mufcular contradions of the round fibres, whofe contradions are lefs con- fpicuoLis in the fmall inteftines. The longitu- dinal fibres of the inteftine, being attached to the cont aded parts as fixed points, draw up and . 2 dilate 23^ Q/' Iniejllnes. dilate the lower parts of the inteftine ; then the next parts of the inteftine, to which the feces are brought, being irritated and contradled in like manner, are immediately after drawn toge- ther by the round and long fibres, by a fuccefiive repetition of which the feces finifh their courfe entirely, through the whole large inteftine ; for wounds in mankind, and the comparative ana- tomy of brute animals, demonftrate thisperiflal- tic motion of the inteftines to the eve, which is alfo confirmed by the antiperidaltic motion, and its confequences or appearances, bv which the matter of glyfters is returned up through the mouth. But thefe proper adtions of the in- teilines themfelves, may he in a good meafure promoted by a contradtion of the muCcles of the abdomen. §.7.9. While the grofs or thick feces of the inteftines afcend by the folds (§, 729.) or valve of the ilium ; the weight of them deprefs the lower fold to the left fide, which draws back the ligament common to each valve, in fuch a manner as to coraprefs and exadtly clofe or fhut the upper fold downward, that nothing may return back into the ilium, which might eafily happen in a fluid flate of the feces, if this port w^as not fo accurately fliut up. From thence they continue to move Howdy forw'ard, more dry, confiftent, and figured by the lame caufes (§. 73 B ) through the whole tradt and ^.repeated flexures of the colon, wdiich is fonre- * times of five or feven feet in length, fo as to .'retain the feces a fpace of time lufficient to ^give^no interruption to the aliairs ol' human f life j Cf the Intejilnes, 239 life ; which time is Ids in proportion than twenty four hours, as the fmall inteftines re- tain their contents a fhorter interval of the fame fpace. §. 740. At length the figured excrement falls into the redlum^ which is infleded firfi; a little downward, and then forward, of a broad de- prelTed figure, at firft defcending contiguous to, and afterwards fpread under the bladder, or va- gina, but conneded more with the former than the latter. Here, for a great while, and often to a great quantity, the faeces are colleded to- gether, in a part which is loofe, or openly fur- rounded with foft vifeera and mufcles, with a good deal of fat. §. 741. The flrudure of the redum differs very much from that of the other inteftines. The external membrane or peritonaeum is only fpread before it, while behind it is fupported by a broad ftratum of the cellular fubftance, re- plenifhed with fat, and many conglobate glan- dules, conneding this inteftine all the way to the os facrum. The mufcular fibres, in this inteftine are much ftronger and more nume- rous, more efpecially the longitudinal ones, than in the other inteftines j being compofed of the three ligaments of the colon, expanded and fe- parated, fiift over the anterior face, and then over the whole inteftine ; which they dilate againft the advancing fasces, and draw back the inteftine, after it has excluded them. But the tranfverfe fibres are alfo ftrong, and the laft of them are oval, furming a protuberant ring^ which iio Of th^ LitefineSi which Is the internal fphinder itlelf, by which tlie opening of the anus is clofed. §. 742. Moreover, the villous tunic, ex-* tremely full of pores, of a tender fubftance, and rough furface, full of reticulated foft protube- rances and wrinkles, has likewife fomc finufes. Namely, that part of the inteftine which is next to the Ikin or outward opening, forms a white firm circle like a valve, into which defcend the longitudinal folds, but incurvated and approach- ing one to another in the circle itfelf. Betwixt thofe folds, are intercepted finus’s, hollow up- wards, and of a greater depth towards the lower extremity of the inteftlne. Into the cavity of thefe open the mouths of the large mucus glandules ; while the margin of the anus itfelf is defended by febaceous glandules, that it might not be excoriated with the harder acrid feces. §. 743. There are alfo proper mufcles which govern the anus. Of thefe the outermoft is the )pl.in^ei\ which is broad and flefliy, confiiling of two plates of half-eliptic fibres, which crofs each otlier towards the coccyx, and towards the genital parts. To the former of which, the fiefiiy bundles degenerating into a callous fabric, defcend, and are inferted into the coccyx : but forward, they are firmdy attached by denfe por- tions of the fame kind, into the fkin of the pe- rina?um ; hut by three flronger portions in the middle, and two in the fides, they are inferted into the bulb of the urethra, whofe lateral parts tliey furround, betwixt the fphindler and levator. The fibres, therefore, of the fphindler, placed betwixt the anterior and pofierior face of the Of the Intejiines, 241 redlum, afcending in a diredt courfe, clofe the opening of the anus, which they furround. With the internal fphindler, the external one is conjoined by flelhy portions, that they may co-operate together. The conftridlion of them is not perpetual but voluntary : for the anus feems to clofe itfelf naturally, if the fmallnefs of its opening be compared with the largenefs of the inteftine above, and with the correfponding wrinkles (§. 741.), aided by the ftrength of the tranfverfe fibres of the internal fphindler, and the incumbent bladder. §. 744. But there is another office belonging to the levators,* which are broad complicated mufcles ; they defeend broadly from betwixt the oppofite protuberances of the offa ifehia, placed under theredlum and bladder ^ and ferve to fuflain the redlum on each fide, and prevent it from fubfiding, or from an unfightly everfion. Moreover the fame fibres of the levator, de- clining broadly from each other, in the nature of a fphindfer, to which they join, ferve to di- late its orbicular fibres, and open the anus; but at the fame time they both elevate and fuftain the inteffine from prolapfing downward, by the prefTure of the hard feces. They arife, as is well known, from the fpine of the ifehium and fynchondrofis of the offa pubis, terminated by the margin of the great foramen of the pubis, and that part of the ifehium, which is above the tubercle. Finally, they meet toge- ther in one above the coccyx, into which they are inferred by numerous fibres. ^ §• 7f5- VoL. II. R 242 Of Intejlines. §. 745. Therefore, whenever the faeces are colleded to fome quantity, within the redlum, fo as to be troublefome, by their weight, irrita- tion, or acrimony, they excite an unealinefs thro' the adjacent vifcera, and are then urged down- ward, by a voluntary preffure through the ftraits of the collapfed inteftine (§. 743.) by the force of the incumbent diaphragm; for by this the vif- cera of the abdomen, which is always full, are determined downward, through the inner rim of the pelvis, fo as to urge upon the contents of the lefs redding bladder and redtum. When the refiftance of the anus is thus overcome, the compreffing forces of the diaphragm abate, and the faeces continue to difcharge from the body, urged only by the periftaltic motion itfelf of the inteftine. After the faeces are expelled, the inteftine is drawn back or up into the body, by its longitudinal fibres ; after w'hich the opening of the anus itfelf is clofely contraded by the two proper iphinders, as at firft. L EC- 243 LECTURE XXXII. Of the Kidneys^ Bladder, and Urine. §. 746. 'HE chyle (§.719.) which Is taken J[ into the blood, contains a good deal of water; the proportion of which would be too great in the reffels, fo as to pafs into the ceE lular fubftance, if it was not expelled again from the body. Therefore a part of this is exhaled through the fkin (§. 43b.) ; and another part, as large, or often more than the former, diftils through the kidneys to the bladder, from whence it is expelled out of the body. §. 747. Thefe kidneys are two vifcera, placed on each fide the fpine of the back, behind the peritonasum, incum^bent upon the diaphragm, and upon the pfoas and quadratus mufcles of the loins; but in fuch a manner, that the right kid- ney is commonly placed lower and more back- ward than the left. Before the right kidney is placed the liver, upon its upper part (§. 670 ), and then the colon covers the reft of its anterior face ; and the left kidney is alfo covered by the fpleen, ftomach, part of the pancreas and the colon. They are tied by ligaments or redupli- cations, formed of the peritoneum to the colon, duodenum, liver and fpleen. Their figure is ,externally convex, with a femielliptic deficiency in their inner fide ; laterally they are fiat or de- prefiTed, inwardly hollow, unequally divided in- to one upper, or longer and thicker plain, and a R 2 lower, 2 44 Of the Kidneys. lower, flenderer extremity. They are firmly inverted by a rtrong external membrane, which is denfe, and adheres very clofely. Betwixt that membrane and the peritonaeum of the loins, there is always interpofed a confiderable quan- tity of fat, by which the whole furface of the kidney is furrounded on all fides, as with a fliell. §. 748. The blood-veflels of the kidneys are very large, as well the arteries, which together exceed the mefenteric, as the veins. And firrt, the renal arteries pafs out from the aorta under that of the mefentery, not always in the fame manner, yet fo that the left is commonly fhorter than the right, and each of them, frequently in two, three, or four dirtindt trunks. From thofe trunks arife the renal arteries of the lower fort, with the adipofe ones belonging to the fat cortex, or capfule of the kidney (§. 747.) ; and not unfrequently they give origin to the fper- matics. The fmaller branches which they re- ceive, are from the fpermatics, and arteries of the loins, which fupply them with fat. §. 749 d he renal veins are very large, more efpecially the left, and more inconrtant in their courfe than the arteries ; for the right is often without a branch, rtiort and concealed, while the left always generates the fpermatic and cap- fular vein of the lame fide, and almort con- rtantly receives the lart branch of the vena azy- gos ; and being of a confiderable breadth, it extends a long way tranfverfely before the aorta, with the duodenum incumbent upon it. Both the arteries and veins of the kidneys arife from 3 the Of the Kidneys. 245 the great trunks laterally, a little defcending in an obtufe angle j and divide themfelves into many branches, a little before they enter the kidney. That the paflage of the'blood through the renal arteries into the veins is very expeditious, readily appears, from the eafy courfe that is afforded to water, wax, or even air injedbed. There are lymphatic veins confiderably large, found about the renal blood-veffels, which give origin to the ciftern of the chyle, or roots of the thoracic du6t (§. 723 ), which are faid to receive the difperfed branches that are fpread under the cel- lular coat of the kidney. §. 750. The nerves of the kidneys arefmall, but numerous j arifing from a confiderable plex- us, communicating on each fide by ganglions or knots, which are generated by the branches of the great femilunar ganglion, conjoined with others from the intercoflal trunk, creeping along from the thorax itfelf ; they enter the kidney, together with the artery, and fend off the middle mefenteric (§. 737.) and likewife the fpermatic nerves. As thefe nerves are fmall, they afford but a moderate degree of fenfibility to the kidney ; and as they winde about the re» nal artery, like a plexus, we may thence un^ derftand how paffions of the mind fuddenly in- creafe the renal difcharge to an exceflive quan- tity; fo that the urine, which was before thick, and little in quantity, is by a nervous fpafm ex- pelled, of a watery confiflance, and in excefSive great quantities, § . 751. Upon the top of each kidney is feated the reqal capfule or glandule, of the cgnelome- R 3 ratQ 246 Of the Ktdnep, rate kind, triangular, and conneded by each of its (ides to the liver, fpleen, pancreas, diaphragm, and kidney j inwardly it is hollow, parted by a fort of feparable ventricle, full of a liquor of a yellowifh red colour, and of a fluid confiftence, almoft like blood ; and in the fcetus, the bulk of this gland exceeds that of the kidney itfelf, but does not afterwards grow larger in the adult. The arteries of thefe capfules are many, chiefly of three kinds; the uppermofl; from the phre- nics, the middle one from the aorta, and the lower ones from the renals ; but the veins are only a large one on each fide, that of the right to the cava, and the left to the renal vein of the fame fide. The faid vein creeps almofl naked, in branches, through the tender ventricle, in a fulcus, dividing the capfule. The ufes of this gland are as yet unknown; although we are led to believe, from the fituation, that it is fubfer- vient to the kidney, and of greater ufe to the foetus; fince it is conffantly found near the kid- neys, and in fo many different animals. The fabric of it approaches very near to that of the thymus ; but it has no vifible excretory du6l, nor does it difcharge any juice, by vifible pores, into the vein. §. 752. The internal fabric of the kidney is Ample enough, and fufficiently known. The bk)od-vefiels having"entered the interval, be- twixt the upper and lower ftratum of the kid- ney, fpread into its fubfiance, furrounded with the celiular web, and divide into branches be- twixt thofe of the pelvis ; beyond this they go out to the cortex, and f-equently form inof- ^ cu'ations. Of the Ktdfiey!. 247 culations, in going betwixt every two branches of the pelvis, whence their circles are extended round the papillae. From thence outward they are continued into and amongft the papillae, by innumerable fmall tendriles, which lead towards the external furface of the kidney (and fome- times, paffing through the proper coat of the kidney itfelf, enter into its adipofe covering) where being changed into minute ferpentine curls, refleded again towards the trunk of the artery, from whence they rofe; thus they form a boundary to the kidney, and are then gradually ftretched out into dired flender duds or tubes, which vifibly receive and depofit the urine from the artery. The fecretion which is made from this artery, may be imitated without difficulty ; by an injedion with wax, water, or air 3 which will pafs from the arteries of the kidney into the ureters. But fuch experiments do not fucceed, in parts that have fmall glandules interpofed, betwixt their ultimate arteries and incipient veins. Betwixt thefe fmall uriniferous duds or tubes run many parallel arteries. §. 753. Thofe uriniferous duds gradually con- verging towards the middle of the kidney, are colleded together in fmall bundles, which near the cavity of the kidney, form round papillre, with their convexity full of pores ; namely, the ultimate diffilling orifices of the duds, which fecrete and depofit the urine into the pelvis. The number of thefe papillae is not altogether certain, but there are thirteen or more of them ; and thefe were in the foetus fodiflind, that the kidney then appeared to confifl of fo many R 4 ^ diftind 248 of the Kidneys. diftind or fmaller kidneys, as there are of thefe papillae, connedled together by a loofe cellular membrane, betwixt each renal portion j and furnilhed every one with its proper cortex of fer- pentine velTels, from whence proceed the uri- niferous duds, alTembled together in a dired bundle. But in adults, the cellular fubdance being condenfed, unites the renal portions and their papillae into one even kidney ; however, it again almoft recovers the condition which it had in the foetus, if the intervening cellular plates are relaxed by often injeding of water. The kidney is alfo remarkably larger in the foetus than in the adult. §. 754. Round the protuberant furface of the faid papillae, is extended a loofe membra- nous covering, in fuch a manner, diftind from the papillae itfelf, as to form a larger fpace, like a tube or funnel, for receiving the papillae into its cavity, projeding down from its upper mar- gin, to which the tube adheres. Two or three of thefe tubes meet together in one, and with others of the fame kind, they at laft form by that union three hollow trunks, which again unite and open, but without the kidney, into one co- nical canal, called the pelvis. §. 755. The blood of the renal artery being lefs fluid than that of the brain, and probably flored with more water, brought by the ferpentine circles of the arteries, depofits the watery parts into thofe redilineal tubes of the papilla ; a great portion of which water con- tains oils and falts, intermixed with earthy par- iicies, or fuch other matters as are fmall enough Of the Kidneys. 249 to pafs through with it. But the fmall diame- ter of each urinifcrous dudt itfelf, at its origin, and its firm refiftance, fcem to exclude the milk or chyle, and the thick or oily and lymphatic parts of the blood, which are capable of har- dening by heat. Hence therefore it is, that the blood paffes fo eafily through the open uri- niferous tubes, whenever it is urged with an increafed celerity 5 or that by a morbid relaxa- tion, they tranfmit not only the oily parts of the blood, but even the milk and nutritious juices themfelves. The urine by fire or putre- fadtion foon changes into a volatile alcaline na- ture, intermixed with a fetid oil, partly em- pyrumatic, yellow, and volatile, and in part very tenacious, to be feparated only by the laft de- grees of fire, under the denomination of phof- phorus j and laftly, it abounds more with earth than any other juice of the human body. [But there is alfo a confiderable proportion of fea- falt refiding in frefh urine, from which it is even feparabic, after a long putrefadlion, in the making of phofphorusj in which procefs a very great part of the urine is changed into volatile alcali. Nor is the urine wholly defti- tute qf a vitriolic acid, or at leafl: one much a- kin to it ; both in that taken from men, as well as in the ftale of cattle. There is again, a fort of fufible, neutro-alcalefcent fait, feparable in the urine, and eafily melting by heat. In fevers, the oily and faline parts of the urine are greatly augmented, together with acrimony ; as we know by its increafed weight, colour, and tenacity.] §• 7J6- 2 JO Of the Kidneys. §. 756. The ureter being a continuation of the pelvis, carries on the urine received from the kidney, by prefTure from the incumbent vif- cera, the contradion of the abdominal mufcles, with thofe of the loins, and the force of the circulation urging the blood behind the fecern- ed fluid. Firft, the ureter, covered by the pe- ritoneum and cellular membrane, has likewife a thin mufcular coat j a fecond cellular one 3 a firm, white, nervous coat; a third cellular one, lined with the innermoft, which is ofafmooth membranous fabric, porous and glandular, in- ternally. Thefe tubes are of different diame- ters in different places. They defcend over the pfoas mufcles, crois over the great iliac blood- veffels into the pelvis, go behind the urinary bladder ; and in the conjundion of the defcend- ing and tranfverfe portions of the bladder, they enter obliquely, betwixt the mufcular fibres and nervous coat ; and fo again, betwixt the ner- vous and villous coat, through which lafl; they open by an orifice obliquely cut off; but they have no valves, neither at their opening In the bladder, nor in any part of their courfe. From their oblique infertion into the bladder, a protu- berant line is formed, by the greater thicknefs of the nervous coat, w’hich defcends to the caput galliginis. §. 757. Nor does there feem to be any other way for dae urine to pafs through the bladder, than by the kidneys and ureters; for although it is cer- tain, that the ftomach, like all other membranes, exhales a moifture thro’ its coats, and tiiough it is not improbable, from experiments, that the bladder Of the Bladder. 251 bladder alfo abforbs j and although the paffage of mineral fpaw waters, by urine, be extremely quick, yet it does not thence follow, that there mufl: be ways, different from that of the ure- ters, to convey the water from the food to the bladder. For the bladder is, on all fides, fepa- rated from the cavity of the abdomen by the peritonaeum j nor is it very likely, that the vapours, which either go out from the bladder, or which are derived towards it from other parts, can here find open pores through the peritonaeum ; nor do membranes imbibe much that have been macerated for any time, fo as to fill their pores with humours 3 and a careful aU tention to the manner, in which mineral wa- ters are difcharged by urine, fufficlently de- monflrate, that there is no fuch rapidity therein, as is commonly imagined j but the ffimulus of the cold water drank, does, like the external cold, applied to the fhin, caufe a concuffion of the bladder and urinary parts, by which they are follicited to repeated difcharges of the old urine, v/hich was before in the body, and not immediately of that which was laff drank. Again, the largenefs of the renal vefTels de- monffrates, that not much lefs than an eighth part of the blood fent to the body is received at a time, and confequently there are above 1000 ounces of blood conveyed through the kidneys in an hou.*' j whence it will appear, but a moderate allowance, for 25 ounces of water to diflil from that quantity of blood, driven thro’ the kidneys in the fame time. Fi- pally, it is certain^ that, both man and brute animals, 252 Of the Bladder, animals, perlfh, if the ureters are clofed up by a ligature j for we then obferve alfo, that no urine can be found in the bladder. §. 758. The urinary bladder is feated in the cavity or bowl of the pelvis, which is an ap- pendix to the abdomen, furrounded on all fides by bones ; but laterally, and at the bottom, only inclofed by mufcles. It is obliquely fituated, fo as to cohere with the os pubis by^a large portion of cellular fubftance, by which it is connedled to the peritonaeum from thence backward, and for a fmall part of its furface before; but be- hind, it is extended to a greater length over the bladder, defcending almoft as far as the in- fertlons of the ureters j from whence it returns back again, either over the redlum or uterus. Behind the bladder, lies the redlum, thefemi- nal veficles, and proftate gland, with the leva- tores ani. In the foetus, the bladder is very long, and fomewhat conical, extending itfelf much above the olTa pubis ; but in the adult, it hardly arifes above thofe bones, even when inflated, becaufe, in them, the pelyis is much larger and deeper in proportion. §. 759. The figure of the bladder is, in ge- neral, oval, flatter before, more convex be- hind, terminated at bottom by a very obtufe or flat head, that lies incumbent upon the redum. Such is the figure of it in an adult man, but, in the foetus, it is almoft cylindrical, and in women, who have had many children, fo much flattened laterally by preffure, that it re- fembles a fort of triangular cone. This change of the figure of the bladder in an adult man, from Of the Bladder. 253 from that of the foetus, feems to arife from the weight of the urine, gradually extending more the lower parts of the bladder, which are moft prefTed j by which means the fides are drawn together from above, fo as to render it fhorter and more concentrated. §. 760. The fabric of the bladder is much like that of all large membranous receptacles. The firft membrane is cellular, in its fore part lax, and replenilhed with fat; but backward it is thinner, where it unites with the redlum. Next to this, follows a mufcular coat, very difficult to defcribe, confifting of pale contradtile fibres, difpofed in various reticulated bundles, not con- tinued one to another, but interrupted with net-like fpaces, in which the nervous coat lies uncovered. The principal firatum of thefe is longitudinal, which, arifing before from the proftate, is frequently, though not always, fo connedled to the fynchondrofis of the ofiTa pu- bis, as feemingly to arife from thence ; thence, afcending and growing broad, they fpread to- wards the conical part upon the upper fide of the bladder, whole extremity they terminate ; here paffing on, they defcend over the pofterior furface, and grow there confiderably broader, ’till,, at length, they are finally terminated in the proftate. Thefe muft necefifarily deprefs the bladder from before, and confequently pro- pel the urine towards its bottom part. §.761. The remaining fibres are very diffi- cultly reduced to any order. They fill the in- tervals of the former by arifing from the proftate backward, and, afcending infieifted, they form a tranf- 254 Bladder. tranfverfe ftratum of fome depth, both in the forward and back part of the bladder. Over thefe are fpread others, irregularly wandering from the longitudinal ftripe, which going for- ward are related to the tranfverfe. §.562. Within the mufcular coat, is fpread the fecond cellular ftratum, of a tender elegant fabric that may be inflated, and fofter than that obferved in the inteftines. Next follows the nervous coat^ as a continuation of the fkin, and refembling the nervous coat of the fto- mach ; over this is fpread a more obfcure villous coat, charged with mucus, and very difficultly feparable from the formerj but folded into^ various wrinkles, of an irregular or uncer- tain order. In the furface of this laft, the pores of the mucous crypttE fometimes appear confpicuous, but not always, without difficulty, pouring out a vifcid foft glue^ §. 763. The veffels and nerves of the blad- der are, in common with thofe. which go to the genital parts, where we fhall defcribe them. They form principally a net- work in the firft or outer cellular ftratum, and then another, in the fecond ftratum, of the fame fubftance. The arteries exhale thro’ the villous coat, as we learn, by experiment, from anatomical injections ; and the veins likewife abforb again, to which’ is owing the greater confiftence and higher co- lour of the urine, by a long retention of it. It has an accurate fenfation, lo as to render all liquors injeCted, even water itfelf, fomewhat painfulj and isdifpofed only to retain and be cafy und_er the healthy urine. The lymphatic vef- fels, bf the Bladdsr. 25^ fels, in the outer cellular ftratum, are eafily de- monftrated ; but their origin is from another part, probably from the adjacent redlum, §. 764. Into this bladder the urine conftantly flows, in a continued thread, as we are aflured, from experience, in morbid and uncommon cafes, in which the extremities of the ureters have appeared to the eye. By flaying fome time in the bladder, and from the abforption of the more watry part, the urine acquires an higher colour, becomes (harper and reddifli-coloured ; ’till, at length, by its bulk and acrimony, irri- tating the fenflble fabric of the bladder, it is thence expelled, firft by the motion of the dia- phragm and abdominal mufcles, by which the inteftines are urged againfl the bladder, in a perfon who is eredl and draining, wherebv the urine makes itfelf a way through a narrow and impeded courfe ; and again, in this adtion, the periftaltic motion of the bladder itfelf, arifing from the contradlion of its mufcular fabric (§ ybi-h has a conliderable (hare. Hence an iichuria follows from too great a dilatation of the bladder, by deflroying the tone or elafticity of the mufcular fibres. §. 765. From the anterior margin of theob- tufe or greater end of the bladder, called its bottom, goes out a (lender canal with a fmall orifice, as a continuation of the bladder itfelf, under the denomination of the urethra; and in this, there is a manifed continuation of the cuticle of the internal coat of the bladder, with its furrounding cellular fubftance, and more ef- pecially a f@lid nervous coat, of which it is pi in- 256 Of the Bladder. principally niade up. This canal goes out for- ward, varying both in its direction and diame- ter, and, in a living man, its courfe is rather a little upward, obliquely afcending betwixt the departing crura of the ofla pubis ; it afterv/ards afcends againft part of their fymphyfis, and again, like an s, inclines downward j but it is fhorter, more open and diredt in women. § 766. This canal of the urethra is firft fur- rounded, on all fides, by the proftate gland ; from whence it goes out naked, for a fmall Ipace, that is immediately continuous belowj with the incipient bulb of the urethra, which likewife furrounds it on all fides above j but the cavernous bodies of the penis chiefly cover it above and laterally, fo as to form a common groove for its reception, and add ftrcngth or firmnefs to this otherwife lax tube. It begins wide from the bladder, and contracts itfelf conically in the proftate, from which, being at liberty, it becomes cylindrical, and enlarges at the firft acceffion of the bulb ; from thence it goes on almofl; cylindrical, and again dilates itlelf a little before its terminat on. §. 767. This canal is governed by various mufcles, either proper to itfelf or belonging to the parts adjacent. And firfl;, in women, there are manifeftly fibres placed round the egrefs of the incipient urethra, which are mofily tranf- verfe, but fome varioufly decuflTating each other, whofe office, and fupport in the vagina, mani- feftly appear ; namely, to deprefs the urethra, like the fphinder, about the opening of which they are difpofed, and, by this means, to dole Of the Bladder, its opening againfl the refilling contradled va- gina and fphindler of the anus. In man there are tranfverfe fibres of the fame kind, but form- ing an arch, that opens upward, they run into the conjundlion of the bladder with the pro- ftate, covering the longitudinal ftripe (§. 76 i.), and proflate itfelf, near the bladder. §.768. But like wife the levator of the anus feems to raife the urethra againfl the os pubis, fo' as to clofe the opening of the bladder into it ; and, in ourfelves living, we may perceive the accelerator conflringed, together with the fphindrer, at the root of the penis, fo as per- fedlly to clofe the opening of the urethra, and prefs back the urine, even while it is flowing ; whence there is no room to doubt, but this mufcle gives a moderate tightnefs for retaining the urine. §. 769. Thefecaufes, with the weight of the urine, urging more upon the bottom of the bladder and againfl the redlum, rather than upon the opening of the urethra, which arifes and afcends higher up, occafion the urine to be retained within the bladder, even in the dead fubjedl, unlefs it be urged by the forces which comprefs the bladder. When the urine is eva- cuated (§. 764.) it runs forth with a greater celerity, in proportion as it comes through a canal fmaller than the diameter of its large re- ceptacle, and, being once difcharged, frees the body from uneafy fenfation. The lafl drops, which remain in the lower part of the bulb, irritating by their weight, are expelled by the accelerator mufcle j namely, a flrong mufcular VoL. II, S expan- 23 S Of the Bladder. expanfion, placed round the bulb, whofe fibre are difpofed in the fliape of a feather, meet- ing together in the middle of the bottom-part of the bulb, and in their fore part fixed by two tendons into the cavernous bodies of the penis, and in their back-part conneded by three mufcular portions to the fphinder of the anus ; two of which portions may be alfo referred to the levators of the anus. This mufcle, when the fphinder is firmly fhut, draws the bulb upward, and, with a confiderable force, alter- nately contrads or fhakes the urethra, fo as to expel the lafl; drops of the urine. §. 770. But as the urine is fiiarp, and the membrane of the urethra very fenfible, and be- caufe the air will likewife enter it ; for thefe reafons nature has fupplied this canal with a large quantity of mucus. This mucus is not only generated from the fources in the bladder, but more efpecially from two conglomerate glandules; one of which isfeated on each fide, in the angle, betwixt the bulb of the urethra and the cavernous body of the penis ; from whence it fends out aflender dud, running, for a confiderable length, through the urethra. Moreover, the whole urethra is full of mucous finufies, of a cylindrical figure, which open or defeend towards the glans, having fmall mucous cryptae placed at their fides, which depofite there a fluid mucus, and difeharge it into the urethra. A larger fort of thefe mucous cryptas are difpofed along the upper fide of the ure- thra, beginning before the bulb, at the origin of the glans. There are others, flill fmaller, mixed Cf the Bladder. 259 mixed with thefe large ones, and placed laterally, and about the urethra. In women alfo there are many and larger of thefe mucous cifterns, which open into their much fhorter urethra, more ef- pecially at its opening. §. 771. The necefTary cleanlinefs and avoca- tions of human life require the urine colleded to be difcharged only at certain times. This difcharge of the urine is not only to free the blood of its fuperfluous water, taken in together with the nutritious chyle, as we fee in the thin watry urine that is made foon after drink- ing, fometimes impregnated with a particular fmell or colour of the nourifhment; but alfo a rancid oil, and the diffolved earth, which is rubbed off from the folid parts (§. 23 5.) muft be this w'ay evacuated, which makes the true or yellow urine of the blood, fharp and foetid, as we obferve it is difcharged a conhderable time after meals, more efpecially in the morning after fieep. From the acrimony of this, in a retention of the urine, the tender veffejs of the brain are fometimes eroded with fatal confe- quences. But thefe advantages of the urinary fecretion could not be joined together, without fome danger of difeafe, from the depofition of the earthy parts of the urine, continually con- fined and at reft j fo that, by repeated additions of the like matter cemented together, a ftone may be at length formed. But the plenty of mu^us, with which the urinary paftages are com- monly defended, is, for the moftpart, afufficient guard againft this diforder, as we fee the ge- nerality of people are free from the ftone j un- S 2 lefs 26 o Of the Bladder. lefs the urine is more than commonly charged with an earthy, tartarous, or chalky matter, increafed by the ufe of hard wines, vifeid food, inadtivity of body, and a retention of the urine beyond the calls of nature ; or finally, a diforder of the kidneys, laying a foundation or bafis for the earthy matter, firft to adhere together. 25i LECTURE XXXIIL Of the Genital Parts in Man. 772. f I ' H E fpermatic veflels conftantly arife near thofe of the kidneys, and almoft in all kinds of animals j by which nature fcems to have intended a double ufeful- nefs in one organ, which might be able to dif- charge the excrement of urine, and bear a re- lation likewife to the genital parts, tho’ placed at a confiderable diftance, in a fpace or interval be- twixt the pelvis and thighs, and fubferviemt to cleanlinefs, modefty, eafinefs of the birth, and the force of throws in delivery. §. 773. The femen mafculinum is firft form- ed in the tedicle, then repofited in the feminal veficles, afterwards ejedted from the penis, and finally received by the uterus, where it renders the female ovum prolific; and therefore, this muft be by the order of our enquiry into thefe particulars. The human teflicles, but fmall in proportion to the bulk of the body, are, in the foetus, lodged within the abdomen behind the peritonaeurq, from whence, by degrees, they defeend into the groins, and are, at laft, in a more advanced age, thruft down into the fero- tum, perhaps partly by their weight, and partly by the impulfe of the influent blood ; yet fome- times they are obferved to remain behind in the ^ groin of adults. This body is often of an oval S 3 figure 262 Male Genitals. figure, fufpended with the fmaller end upwards, and the obtufe end downwards. §. 774. It is defended by various Integu- ments, of which the firft and outermoft is that of the fcrotum, made up of a clofe cellular flratum, replenifhed with vefTels, and clofely adhering to the fkin, which lafl: has a kind of elaflic or contradlile motion, at the approach of cold and in the aft of venery, although with- out any mufcular fabric j yet it has commonly aftlon enough to wrinkle the fcrotum, and draw up the tefticles. Next to this a cellular coat, commonly called dartos, is placed round each of the tefticles feparately, by the conjunftion of which, together in the middle, is formed a kind of feptum, which appears more remark- able in a dry preparation j and this feptum is often not perforated in Its upper part. §. Within the dartos is fpread a loofe cellular ftratum, without any fat, except in the lower part of the fcrotum, and may be inflated like the fame fubftance in other parts. Next follows a mufcle, from its offlce called cre- mafter ; which arifes from the degenerating fibres of the lefs oblique mufcle of the abdo- men, and from the tendon of the external ob- liquus, called by fome, a ligament, and, by others, fibres, defcending from the os pubis backward into a vagina or capfule, which, every way furrounding the tefticle, ferves to comprefs, elevate, and forward its contents. §. 776. Next to this follows the fecond cel- lular ftratum, whofe fpungy fabric is continued with the outermoft, that lies round the peri- tonaeum j T’he Male Genitals. 263 tonaeum ; and this fecond ftratum Is called tu- nica vaginalis, in which the veficles or cells of its fabric, by inflation, appear larger than eife- where. At the beginning of the tefticle, above the epididymus, it is, in a manner, fo fepa- rated from the reft above the tefticle, towards the rings of the abdominal mufcles, that the inflation can hardly be continued through. Betwixt this laft membrane and the following is a fpace, into which are exhaled thin vapours, and fometimes a water is collected. The inner coat, called albuginea, is a ftrong, white, com- padl membrane, which immediately invefts and confines the proper fubftance of the tefticle it- felf. §. 777. To the tefticle the fpermatlc artery defcends, one on each fide, generated by the aorta below the renal arteries ; but not unfre- quently from the renal arteries themfelves; from thofe of the capfules, or from the aorta itfelf above the emulgents. This artery, the fmalleft in the body, in proportion to its length, de- fcends a long way outward before the pfoas mufcle, and gives fmall branches to the fat of the kidney, to the ureter, mefocolon, glandules of the loins, and to the peritonaeum ; but more efpecially towards the bottom of the kidney, it gives a remarkable branch infledled, without leflening itfelf, that takes a ferpentine courfe behind the peritonaeum, as far as the ring of the abdomen. This ring is formed entirely of the ten- dinous fibres, defcendingfrom the external oblique mufcle, interrupted in their oblique defcent by a long aperture, growing wider’ downward ; S ^ from 264 Male Genitah'. from this aperture moft of the fmaller inner fibres are broadly detached to the os pubis, and others crofling cohere with the fibres be- longing to the other fide of the mufcle, which, being colledled together, is called the inner co- lumn. Other ftronger external fibres, diftin- guifhed from the former by the aperture, are broadly inferted by a thick bundle into the outer fide of the os pubis, under the deno- mination of the external column ; from whence various fibres run off in a broad tape to the groin. The upper part of this opening is, in fome meafure, clofed up by fibres, arifing from the outer column, and afcending in a curve direction, round the inner and weaker column. Below thefe fibres there is often a fmall open- ing left, parted off by tendinous fibres, through which defcends the fperrnatic artery with the vein, and vas deferens, with a good deal of cellular fubflance, by which they are wrapt to- gether into a cylindrical cord 5 from whence, advancing to the groin, it defcends into the fcrotum, where the fperrnatic artery gives many fmall branches to the cremaficr, to the cellular coat, and to the feptum of the fcrotum, and then defcends in a double plexus, to the tefticlc, of which the principal comes from betwixt the epididymis and origin of the vas deferens, at the middle and lower part of the tefticle, and then goes, by tranfverfe branches, through the albuginea: the other plexus, that accompanies the vas deferens in the upper part of the te- fticle, has a like termination. There are other fmall arteries, which go to the coverings of the tefticle ^he Male Genitals. 265 tefticle from the epigaftrics, and others from thofe of the bladder, which follow the courfe of the vas deferens, both which communi- cate with the fpermatic velTel. §. 778. Many of thefe fmall arteries play about the epididymis ; but the larger of them fpread tranfverfely through the albuginea, which they perforate in feveral places, to enter the innermoft fabric of the tefticle, through which they are minutely ramified in all points, and fe- parated by numberlefs membranous partitions. There is no large anaftimofis or communica- tion betwixt the fpermatic artery and vein here, any more than in other parts of the body j nor is there any red blood received into thofe branches that pafs through the albuginea to the innermofi: fubftance of the^ tefticle. But from the long courfe of this artery, the fmallnefs of its diameter, the number of ferpentine flexures, the great ratio of the dividing branches to their trunk, and the coldnefs of their fubcutaneous diftribution, demonftrate, that the blood flows not only in a fmall quantity, but very flowly to the tefticle. §. 779. The fpermatic vein of the right fide, is inferted into the cava, but that of the left pours its blood into that emulgent vein, or into both : it is confiderably larger than the artery, and takes the fame courfe in company with that ; but both its trunk and branches are much larger and more numerous, very ferpentine, and formed into a bunchy plexus of confiderable length, which is interwove with the artery, and continued as low as the tefticle j there by degrees 266 Male Genitals. dividing into two, like the artery. There are very rarely any valves in this vein. Thefe ex- ternal coverings of the tefticle have arteries from the epigaftrics j the fcrotum, from the crural arteries, and thofe of the trunk, with an inter- nal branch, which is called arteria pudenda % the fellow veins go to the faphena, and to the crural trunks. §. 780. The nerves of the teflicle are many,- whence it has a peculiar tendernefs of fenfation; infomuch that faintings and convulfions follow from bruifing or injuring the tefticle. Some of them arife deep from the renal plexus, and follow the courfe of the fpermatic veffels. Others are fuperficial to the coverings of the tefticle, from the third pair of the nerves of the loins, and others of that order. I have fre- quently obferved lymphatic veffels in the fper- matic cord, which are judged to arife from the tefticle itfelf, and mix themfelves with thofe that accompany the inguinal blood-veffels, §. 781. The blood moved flowly and in a fmall quantity through the fpermatic artery, by which it is brought to the inner fabric of the Intefticle (§, yyj-), is there drained into ex- haling fmall veffels, which by analogy we judge to be continuous with the feminiferous veffels or duds, which bundled together, make up the whole body ot the tefticle. Thefe fe- miniferous veffels are exceeding fmall, ferpen- tine, firm or folid, and have a very Imall light in proportion to their membranes -, they are colleded together into bundles, above twenty in number, divided by diftind cells or partiti- ons. Male Genitals. 267 ons, which defcend from the albuginea to condudl the arteries and veins. In each of thefe cells there is a feminiferous du6t, to con- vey the fecreted humour from the feminife- rous vafcules. Twenty or more of thefe du£ts form a net-work, adhering to the furface of the albuginea, and forming inofcula- tions one with another. From the fald net in the upper part of the epididymis, afcend ten or twelve du(fts, which being contorted together into folds, form as many vafcular cones, that are joined together by an intermediate cellular fubftance, and lying incumbent one upon ano- ther, then form the epididymis, and foon meet together into one even duft. §. 782. This du6l being intricately wove by an infinite number of folds and ferpentine flexures, after a manner not imitated in any other part of the body, and connedled together by a great number of loofe cellular ftrata, is afterwards colledled by a membrane of the al- buginea into one bundle, called the epidydimis, or appendix of the tefticle ; which goes round the outer and pofterior margin of the tefticle, adhering thereto by its thicker head, joined with a good deal of cellular fubftance, while in its lower, middle, and flenderer part it ad- heres in feme meafure, and is in part free, in fuch a manner, that it intercepts a fort of im- pervious bag, betwixt itfelf and the tefticle. But the dueft of w'hich it is compofed, grows larger as it defeends, being largeft at the bottom of the tefticle; from whence again afeending along 268 Male Genitah. along the pofterlor face of the tefticle, in a di- redtion contrary to itfelf, it by degrees fpreads open its fpiral convolutions, and comes out much larger, under the denomination of -oai five du 5 lm deferens. This is the courfe defcribed by the femen, propelled forward by the motion of the fucceeding juices in the tefticle j and per- haps, in fome meafure, though flowly, by the contradllon of the crem after : as we may rea- fonably fuppofe, from the numberlefs fpires and convolutions formed by the epididymis, obftrufting almoft every kind of injection; and as we may conclude, from the length of time, that is required to fill the feminal veficles again, after they have been once exhaufted. §. 783. The cylindric dudlus deferens being made of a very thick fpungy fubftance, in- cluded betwixt two firm membranes, bored through with a very fmall thread or light, af- cends in company with the cord of the fpermatic veftels, and together with them, pafies through the ring of the abdomen (§. 777-) : thence it defcends into the pelvis, and applying itfelf to the bladder, betwixt the ureters, it foon after meets the fubjaccnt receptacles, called the vef- cnlce jeminales. Here it goes along the inner fide or edge of the veficle, as far as the proftate glandule ; and dilating in its pafiage, forms a ferpentine flexure, that begins itfelf to put on a cellular appearance. But very near the proftate it unites in an acute angle, with a conical duernous bodies. §. 796. Thefe cavernous bodies then of the penis, having their fpungy fabric diftended, by the blood retained by the veins, and ftill pro- pelled by the arteries, become rigidly turgid, and fuftain the otherwife flaccid, or but weakly filled urethra, in fuch a manner that it may be able to conduct the femen into the diflant womb. All this is demonftrated from the difledtion of brute animals in the adt of venery, from an artificial eredtion, and from the in- jedlion of liquid matters into the veffels of the penis. But the caufe of this diflenfion remains ifill to be explained. The diflribution of the blood-veflels into the genital parts are there- fore to be here deferibed, to make it evident how ready the compreffing caufe conflantly is to adl upon the veins. §. 797. The aorta at the fourth vertebra of the loins, and the vena cava at the fifth, are bifur- cated or divided, the former before the latter. The common iliac branches, not vet arrived to the middle of the interval in the thighs, fend off inward and downward, a confiderable artery, called the hypogaftric, which in the foetus The Male Genitals. 279 foetus is larger than the femoral artery, and in the adult is equal to it. This defcending into the pelvis, divides into four, five, or fix prin- cipal branches, of which the firfi; is the iliacus anterior, which fupplies branches upward, to the dura mater and cauda equina of the fpine, and into the os facrum. The next, or facra- lateral artery goes off from the bone of that name, when it does not arife from the former ; and the third or iliaca-pofterior, is diftributed to the glutei mufcles. The fourth is the ifchia- tica defcendens, to feveral mufcles, nervts, and levators of the anus. The fifth trunk is that of the haemorrhoidea infima five pudenda com- munis, which in the cavity of the pelvis fends confiderable branches to the bladder and redtum ; after which, joining with the mefen- terics, and going out of the pelvis, it creeps by the fide of the obturator, and gives off the ex- ternal hasmorrhoideals, to the fphindter and fkin of the anus j then dividing, it goes with an in- ternal branch to the bulb of the urethra, fur- face of the proflate, and infide of the corpus cavernofum penis, while by another branch it runs along the back of the penis, according to the diredion^of its bodies, and terminates with them by ramifications into the fldn. The fixth is the obturatrix, fpent upon the joint of the fe- mur and adjacent mufcles. The lafl is the um- bilical artery, to be deferibed in treating of the foetus ; although in adults it fends off fome branches to the bladder, from its thick callous body or vagina. Sometimes one or more of thefe arteries come from the common trunk. T 4 The 200 Male Genltah. The fkin of the penis and fcrotum have their arteries from the epigaftric, and from the inter- nal branch of the crural. Thefe external ar- teries communicate in many places with the in- ternal. §. 79B. The veins are, in general, diftri- buted in like order with the arteries; they come off in two trunks from the iliacs, joining together into a net, and then the haemorrhoidal vein, bending round under the os pubis, forms a large plexus, fpread with the veins of the pelvis upon the proftate and feminal veficles ; from hence the great venadorfi penis arifes, v hich is often lingle, and furnilhed with valves ;o forward the return of the blood. The external veins go to the faphena and crural, communicating in feveral places with the internal veins, more cfpecially at the bafs of the praepuce. §. 799. Lymphatic vefl'els of the penis are, by moft eminent anatomids, faid to run under the Ikin towards the groins. The nerves of this part are both numerous and very large, and ac- company the arteries of the penis, from the trunk of the great fciatic nerve. But the blad- der, redum, and uterus are fupplied by the lower mefenteric plexus, which arifes from the middle one (§. 763.), defcending into the pelvis. §. 800. In order to didend the penis there mud be either a compreiTure of the great vein (§• 79^'^’ ^ condridion of the leder veins, that every where open within the cavernous bodies to hinder them from abforbing and re- turning the olood from the arteries. The iird, how- Ti'he Male Genitals. 281 however, may be effedled by the levator, draw- ing up the proftate ; but it is very probable, that as we fee in the nipples of the fuckling mother, in the gills of the peacock, and in the blufhing or rednefs of the face, from paffions of the mind, as well as from brute animals, which all couple without the ufe of any eredtor mufcle 5 from all thefe it is probable, that the courfe of the blood through the vein may be retarded, without the immediate ufe of any mufcle ; and that, by the power of the latent multitude of fmall nervous bridles, by whofe conftridtion, from the force of pleafure, the veins are comprefled and ftraitned, fo as to return lefs blood to the trunks, at that time, than what is imported by the arteries. But the caufe of this conftridtion in the nervous bridles, or fphindters themfelves, depends upon a various irritation of the nerves, belonging to the penis and urethra, either from an external fridlxon, or from venereal thoughts or dreams, a redun- dancy of good femen, a diftenhon of the blad- der with urine, or a greater determination of the blood’s courfe to the abdomen, after a meal j or laftly, from various irritations by diuretic medicines, poifons, ftripes or flogging, epilepfies, or like irritation. §. 801. A long continued and violent erec- tion is commonly joined, at lafl;, with an ex- pulfion of the femen, at that time, when, at length, the cellular fpaces of the urethra and its continuous glands, which are at lafl; filled, become fo far diflended, with a large quantity cf warm blood, that the nervous papifliE, flretched 202 The Male Genii ah. ilretched out in the latter, become violently aiteded from the irritating or pleafurable caufe ; and hereupon the feminal veficles are evacuated by the levator mufclcs of the anus, which prefs them againft the refifting bladder with a con- vulfive motion, excited either by a voluptuous imagination, or from the pruritus, that is ex- quifite irv the nerves of the glans. Hence the femen is never difcharged with any of the urine, in an healthy man ; becaufe the expul- lion of it requires the bladder to be clofcd or drawn up firmly together ; for, while lax, it affords little or no rcfiftance to the feminal veficles. At the fame time, with the levators, a< 5 ls the compreffor of the proftate, a broad thin mufcle, not conflantly found, arifing from the os pubis, at its meeting with a branch of the ifchium, and inferted into the anus and bulb of the urethra, largely expanded together with its fellow mufcle over the proflate. The tranf- verfe mufcles, which are one, two, or three, arife in common with the os ifchium, at the beginning of the ereftor, whence its principal bundles, going betwixt the anus and bulb of the urethra, conjoin together, and feem to di- late the canal for the reception of the femen, expreffed from the veficles. §.802. Soon afterwards the powers, conftring- ing the urethra, are, from the irritation of the very fenfible fabric of that canal, put into ac- tion. To this conftridlion conduce principally the accelerator (§. 769,), which makes a power- ful concufiion of the bulb and adjacent part of the urethra, fo as to propel the contents more fwiftly, ^he Male Genitah. 285 fwiftly, in proportion as the bulb has a larger diameter than that of the urethra. But that this may a6t firmly, the fphindler of the anus, together with that of the bladder, mufi: be well ll:iut. The accelerator mufcle feems alfo prin- cipally concerned in the eredlon, by com- preflang the veins of the corpus cavernofum of the urethra. At the fame time the eredlores penis, as they are called, arifing from the tu- bercles of the ifchium, become ftrong and are inferted into the cavernous bodies, fuftaininp- the penis, at a fort of medium, betwixt the tranfverfe and perpendicular diredlion. Thus the femen is drove, either into the vagina or uterus itfelf, in a prolific coition ; the whole adion of which is very impetuous, and comes near to a convullion ; w'-hence it wonderfully weakens the habit, and largely injures the w'hole nervous fyfiem. LEC- 284 LECTURE XXXIV. Of the Virgin Uterus^ §. 803. f I ''HE uterus is feated in the upper part of the pelvis, with the bladder before, and the re< 5 tum behind it, without adhering to either of them. In wo- men, the peritonaeum defcends from the os pubis into the pelvis, over the pofterior face of the bladder, down to the bottom or mouth of the uterus : from whence again it afcends over the forefide of the uterus, and, paffing round its convexity, de'cends on the pofterior ftde down to the vagina, from whence it ex- tends laterally or tranfverfely on each ftde, in- cluding the redlum with lunatcd folds, which is all the difference betwixt the female and male peritonaeum. But this fame peritonaeum, com- ing into the pelvis from the iliac veftels, and broadly adhering to the ftdes of the uterus and vagina, is folded back over itfelf, and divides the pelvis almoft into two, like a partition, under the denomination of ligamentum latum. Thus the peritonaeum accurately connedls the uterus, without the intervention of any fat, fo as to ferve it on all ftdes, as an external coat or co- vering. §, 804. The figure of the uterus is fome- what like a depreffed pear, flatly convex before, round behind, with acute edges on each ftde, and at the meeting of its convexities 5 but converging, gra- The Virgin Uterus] 285 gradually afterwards for fome way, In its upper part, almoft parallel. It has a peculiar fabric, being made up of a clofe, firm, but fome- what fucculent and cellular flefli, in which we perceive the appearance of mufcular fibres, more efpecially in the gravid uterus, difpofed in various circles, and particularly at the fundus betwixt the tubes, h s for any mucous finulTes, varioully branching and dividing within the flefh of the uterus, after repeated enquiries, we now declare, that we have not been able to find any ; only fome common fmall vefiels, furrounded with cellular fubftance, bv which their diameters are fuftained. The internal membrane of the uterus is fcarcely diftinguifli- able or feparable ; but fuch a one there is, con- tinued from the cuticle, in the upper part of the cavity, fleecy, and in the lower part, cal- lous, like valves, The cavity of the uterus is fmall, for the mofi: part triangular upward, and below like a comprefTed cylinder. The cylindric part, which is called the cervix or neck, is altogether rough, with callous wrinkles rifing up into an edge, whence they incline towards the vagina j thefe recede laterally from the anterior and pofterior margin, joining toge- ther by fmall wrinkles, in the intervals of which are fmall mucous finufies, with fmall pellucid fpherules, filled with a very clear liquor, in fome parts interfperfed through the upper region of the cervix uteri, differing both in their num- ber and magnitude. It is not uncommon for the uteruo to be diflinguifhed by a line or pro- tuberance extended through its middle. The 2 cervix 286 The Virgin Uterus, cervix is terminated, by the os internum uteri, with a tranfverfe rim, forming protuberant lips, which project for fome length into the va- gina ; there' are alfc mucous finuifes, filled with a vifcid mucilage, about the tumid lips and their finuofities. §. 805. The triangular part of the uterus fends out, from its lateral angles, two canals, in fome meafure folded together by the cellular fub- fiance, growing gradually broader, like a trum- pet, and, being again a little contradled towards their extremity, they proceed towards the ovary, firfi; in a tranl'verfe direction, and afterwards a little defcending, but with fome variation, un- der the denomination of the uterine tubes. Their external membrane is from the perito- naeum, for they are included within the dupli- cature of the broad ligament (§. 803.), which is a produdtion of that membrane ; internally they are wrinkled almoft reticularly, lined with mucus, extended to a confiderable length by intervening plates or folds, and terminated in a fort of fringe or ruffle, that broadly crowns the opening of the tube, which is alfo con- neded to the ovary. Betwixt the two mem- branes is fomething of a fpungy cellular fub- fiance, of a flender texture. There are alfo great numbers of vefl'els, and perhaps fome mufcular fibres, but the latter are more ob- feure. §. 806. But the evarieSy included in the fame duplicature of the broad ligament behind, the tubes, are feated traiifverfely, and conjoined • to T’he Virgin Uterus, 22 y to the fald tubes by a ligamentai*y expanfion of their own, which is long enough to allow them a free motion ; they are fomewhat of an oblong or oval figure, depreffed on each fide, convex upon their unconne£led fide, and half elliptical, extending fomewhat longer than the other thin fide, which is more diredl and con- nedted to the ligament; their fabric nearly enough refembles that of the uterus itfelf, being a clofe, white, cellular fubftance, com- pared together, without any fat. But even in the virgin ovary there are fmall, round, lym- phatic fpherules, formed of a pulpy, and fome- what firm membrane, which are filled with a coagulable lymph, of an uncertain number, to twelve in one ovary. The margin of the broad ligament, receding from the uterus to fuflain the ovary, has fomething of a more folid and thick fubftance, refembling a ligament. §. 807. Laftly, the uterus fends out, from the fame lateral angles, of its triangular body downward, a kind of fafciculus, compofed of long cellular fibres and fmall veffels, which, becoming fmall in their progrefs, goes out of the pelvis through the ring of the abdomen (§• 777-) into the groin, where it fplits into branches, and diffolves into fmall veffels, which communicate with the epigaftrics. Whether or no it has any long fibres propagated from the uterus itfelf, does not plainly appear. §. 808. The arteries of the uterus are from ■ ■ the hypogaftrics, a confiderable branch of which goes off, “ like that to the bottom of the blad- der in men, ^ or, at leaft, it arifes from the um- bilical 288 ^he Virgin Uterus. bilical trunk, or immediately below that trunk, and makes the common artery, belonging to the uterus, bladder, and rectum , upon the lower parts of which it fpreads, and, afcending upward, forms various inofculations with the fpermatics. Thefe lafl; vefTels have the fame origin as in men (§.778.), and form a plexus, which, from its hmilitude to the tendrils of a vine, is called pampiniformis ; afterwards, defcending over the pfoas mufcle into the pelvis, it divides into two plexulfes, the anterior of which furrounds the ovary itfelf, with many circles, elegantly diftri- buted through its fubftance. The poflerior both fupplies the tube, and defcends to the ute- rus itfelf, in which it fends out winding branches upward and downward, and fome branches that are detached to the bladder. Another ar- tery is the middle haemorrhoidal, coming from the common trunk of the pudendeal, a conli- derable way forward with the vagina ; to which, and to the bladder and redlum, it is diftributed. The beginning of the vagina likewife, and the clitoris, have arteries from the external haemor- rhoideal, which are diilributed like thole of the penis, fome inwardly, others luperficially. §, 809. The courfe of the uterine veins is like to that of the arteries, forming a plexus from the external hsmorrhoideal, or from thole of the bladder, coniunCtly to which go thofe of the clitoris, alter the manner we defcribed in the penis (§. 798). Valves there are none in thefe veins, except a few in the Ipermatics. Lymphatic vell'els are frequently feea in the uterus of brute animals; but, in the human fpecies. 7 Jje Virgin U'om^. 289 fpecies, there are not yet any difcovered, at lead by my own obfervation. The nerves are fupplied from the lower mefocolic plexus, which fends out large branches to the bladder, womb, and redtum ^ befides which, there are a few nervous twigs, which defcend through the broad ligament to the ovaries, and others from the nerve, that goes with the veflels to the clitoris. The great number of the nerves, therefore, make thefe parts extremely fenlible. §. 8fO. The defcriptions, we have hitherto given, are in common to all ages of the female ; but about the 13 th or 14th year, near at the fame time whenfemen begins to form itfelf in the male, there are likewife considerable changes produced in the female. For, at this time, the whole mafs of blood begins to circulate in the girl with an increafed force, the breads are filled out, the pubes begin to be cloathed, and, at the fame time, the menfes, in fome mea- fure, make their appearance. But before the mendrual flux, there are various fymptoms ex"- cited in the loins, heavy pains, head-achs, and cutaneous pudules commonly proceed. For now the fleecy veflels of the uterus, which, in the date of the foetus, were wdiite, and tran- fuded a fort of milk, as, in the young girl, they tranfuded a ferous liquor, do now begin to fwcli With blood; the red parts of which are depolited through the vefTels, into the cavity of the uterus. This continues fome days, while, in the.;mean time, the flrd troublefome fymp- toms -.abate, and the uterine vedels, gradually contrafting their openings, again didil oriiy .a Vo-L.-,II, U -little 290 Virgin Womb. Iktle ferous moiflure, as before. But then the fame efforts return again, at uncertain in- tervals in tender virgins, ’till, at length, by degrees, they keep near to the end of the fourth week, at which time follows a flux ot blood, as before, which is periodieadv continued to about the 50th year ; though the diet, country, conftitution, and way of life caufe a great va- riation in this dilcharge. §. 81 1. This difcharge of blood, from the veffels of the uterus itfelf, is demonftrated by infpedtion, in women who have died in the midfl: of their courfes ; and, in living women, who having an inverfion of the uterus, the blood has been feen plainly to diftil from the open orifices : it alfo appears from the nature of the uterus itfelf, full of foft fpungy vefl'els, compared with the thin, callous, little fleecy, and almoft bloodlefs fubftance of the vagina. But that this is a good and found blood, in an healthy v/oman, appears both from the fore- going and innumerable other obfervations. §. 812. Since none, but the human fpecies, are properly fubjedt to this menflrual flux ot blood, (although there are fome animals, who, at the time of their vernal copulation, diflil a fmall quantity of blood from their genitals) and fince the body^of the male is always tree from the like difcharge, it has been a great en- quiry, in all ages, what fhould be the caufe of this fanguine excretion, peculiar to the fair fex. To this effedl, the attradtion of the moon, which is known to raife the tides of the fea, has been accufed in all ages j others have referred it to a T^he Virgin Womb. ifharp ftimulating humour, fecreted iii the ge- nital parts themfelves But if the moon was the parent of this efFed:, it would appear, in all women, at jhe fame time, which is contrary to experience j fince there is never a day, in which there are not many women feized with this flux, nor are there fewer in the decreafe, than the increafe of the moon. As to any fharp ferment feated in the uterus or its parts, it will be always enquired for in vain, where there are none but mild mucous juices, and where venery, v/hich expels all thofe juices, neither increafes nor lefTcns the menflrual flux; but laflly, that it proceeds entirely from a ple- thora or too great a fulnefs of blood, appears from hence ; that, by a retention, the courfes have been known to break through all the other organs of the body, where no vellicating fer- ment could he feated, even fo as to burft open the veflels of each organ. O §. ^13. Nature has, in general, given women a body with fofter or loofer veflels, and folids that are lefs elaftic ; then' mufcles are alfo fmaller, with a greater quantity of fat interpofed both betwixt them and their fibres ; the bones too are flenderer and lefs folid, and their furfaces have fewer procefTes and afperities. Moreover, the pelvis of the female is, in all its dimenfions, larger ; the ofla ilia fpread farther from each other, and the os facrum recedes more back- ward from the bones of the pubes, while the ofla ifchii depart more from each other below ; but above all, the angle, in which the bones of the pubes meet together to form an arch, is, in U 2 the 292 ^he Virgin Womb. the female, remarkably more large or obtufe. Moreover, the hypogaftric and uterine arteries are confiderably larger in women than in men, and have a greater proportion of light with refpeft to the thicknefs of their coats • but the veins are, in proportion, lets ample than in men, and of a more firm refifiing texture, than in other parts of the body From hence it follows, that the blood, brought by the arte- rial trunk to the womb, hv paffing from a weaker artery into a narrow and more refift- ing vein, will meet with a more difficult re- turn, and confequently endeavour to efcape or go off by the lateral veffels. §.814. The female infant new-born has her lower limbs very fmall, and the greater part of the blood, belonging to the iliac arteries, gees to the umbilicals, fending down only a fmall portion to the pelvis, which is confequently fmall, and but little concave ; fo that the blad- der and uterus itfelf, with the ovaries, projedt beyond the rim of the pelvis. But when the umbilical artery is tied, all the blood of the iliac artery defeends to the pelvis and lower limbs, which, of courfe, grow larger, and the pelvis fpreads wider and deeper : fo that, by degrees, the womb and bladder are received into its cavity, v.fithout being any longer com- preffed by the inteftines and peritonaeum, when the abdominal mufclesurge down upon the lower parts of the abdomen. §. 815. When the growth is advanced to puberty, we find the arteries of the uterus and pelvis univerfally larger, which, in the foe- tus, T"he Virgin Womb. 293 tuSj were extremely fmall ; and fo much are they all changed, that the hemorrhoidal artery ferves now as a trunk to the hypogaftric (§• 797 )> of what was before the um- bilical artery. Therefore, at this age of life, a greater quantity of blood will be fent to the uterus, vagina, and clitoris, than was before ufual. §. 816. At the fame time, when the growth of the body begins confiderably to diminitli, the blood, finding eafy admittance into the compleated vifcera, is made in a greater quan- tity, the appetite being now vei;y fliarp in ei- ther fex, in both which a plethora from thence follows, which, in the male, vents itfelf fre- quently by the nofe, from the exhaling vefTels of the pituitary membrane being dilated to fo great a degree without a rupture, as to let the red blood diftil through them (§,459.). But, in the female, the fame plethora finds a more eafy vent downward, being that way direded partly by the weight of the blood itfelf, to ‘the uterine vefTels now much enlarged, of a foft fleecy fabric, feated in a loofe hollow part, with a great deal of cellular fabric interfperfed, which is very yielding and fucculent, as we ob- ferve in the womb; from thefe caufes, the vefTels being eafily difiendible, the blood finds a more eafy pafTage through the very foft fleecy exhaling vefTels, which open into the ca- vity of the uterus, as being there lefs refifted than in its return by the veins, or in taking a courfe through any other part; becaufe, in females, we'obferve the arteries of the head U 3 are 2 94 Virgin Womh. are both fmal'ler in proportion, and of a more firm refifting texture. The blood is, therefore, firftcolledled in the veffels of the uterus, which, at this time, by repeated dilTeclions, are ob- ferved turgid or fwelled ; next it is accumulated in the arteries of the loins and the aorta itfelf, which, urging on a new torrent of blood, im- pelled from the heart by degrees, augments the force, fo far as to open and wedge the red blood into the ferous veffels, which, at firft, tranfnht an increafed quantity of warm mucus, afterward a reddilh coloured ferum, and, by further opening, they, at laft, emit the red blood itfdf, which, however, in this difchargc, has ufually a greater proportion of ferum. The fame greater impulfe of blood, determined to the genital parts, drives out the hitherto latent hairs, increafes the bulk of the clitoris, dilates the cavernous plexus of the vagina, and whets, the female appetite towards venery. Accord- ingly we find, that the quantity of the men- flrual flux and the earlinefs of their appearance are promoted by every thing, that either in- creafes ti^e quantity or momentum of the blood, with refpedt to the body in general, or which diredl the courfe of the blood more particularly towards the uterus j fuch as joy, lull, bathing of the feet, &c. §. 817. When fix or eight ounces of blood have been thus evacuated, the unloaded arteries now exert a greater force of elaflicity, and, like all arteries that have been overcharged with blood, contradl themfelves, by degrees, to a lefs diameter, fo as, at length, to give paffige only ^he Virgin Womb. 295 only to the former thin exhaling moifture ; but the plethora or quantity of blood, being again increafed from the fame caufes, a like difcharge will always more eafily enfue, or return thro’ the veffels of the uterus, after they have been once thus opened fo that, except in extraor- dinary cafes, it rarely feeks for a different paf- fage. Nor is there any occafion to perplex ourfelves about the caufe, why this periodical difcharge is, for the moft part, nearly regular or menflrual ; for this depends upon the pro- portion of the quantity and momentum of the blood daily colledted, together with the refi- flance of the uterus, which is to yield again gra- dually to the firft courfe. Therefore this cri- tical difcharge of blood never waits for the in- terval of a month, but flows fooner or later, according as the greater quantity of blood, in plethoric women, is determined by lufl:, or other caufes, towards the uterus. Finally, they ceafe to flow altogether, when the uterus, like all the other folid parts of the body, has acquired fo great a degree of hardnefs and reflflance, as cannot be overcome by the declining force of the heart and arteries, by which the blood and juices are drove on through all the veffels. This increafed hardnefs in the old uterus is fo re- marka!ble in the arteries and ovaries, that it eafily difcovers itfelf both to the knife and the injeftions of theanatomift. But, in general, brute animals have no courfes, becaufe, in them, the womb is, in a manner, rather membranous than flefliy, with very firm or refifting veffels, which, with the difference of their poflure, U 4 never 296 ^he Virgin Womb. never permit a natural hsemorrhage from the §. 818. It will, perhaps, be demanded, why the breads fill out at the fame time with the ap- proach of the menfes ? we are to obferve, that the breafts have many particulars in their fabric, common to that of the uterus, as appears from the fecretion of the milk in them, after the birth of the fcetus, which increafes ordiminifhes, in proportion as the lochial flux is either increafed or diminilhed ; from the fimilitude of the ferous liquor, like whey, found in the uterus, fo as to refemble milk, in thofe who do not fuckle their children, being of a thin and white confiftence, appearing very evidently in brute animals ; alfo from the turgefcence or eredion of the pa- pilltE or nipples of the breafl; by fridlion, ana- logous to the eredlion of the clitoris. There- fore the fame caufe, which diflend the vefiels of the uterus, likewife determine the blood more plentifully to the breafts ; the confequence of which is an increafed bulk and turgelcence of the conglomerate glandules and cellular fa- bric, which compofe the breads. genital parts. L E C- 297 LECTURE XXXV. Of the Tregnant Uterus. §. 819. T N the preceding condition the ute- ^ rus constantly remains, unlefs, by congrefs with the male, it becomes impreg- nated ; towards which, nature has given women a covetous appetite, as well as for the taking of food ; and for this fl:ie has likewife framed pe- culiar organs. She has firft added to the womb a vagina or round membranous cavity, ea^ly dilatable, which, as we have already feen (§. 804.), embraces and furrounds the projedting mouth of the. uterus j from whence itdefcends obliquely forward under the bladder, which lies before it, and refting upon the rectum with which it adheres, and advances to an opening fufficiently large below the urethra. This opening, in the foetus and in virgins, has a re- markably wrinkled valve, formed as a produc- tion of the Skin and cuticle, under the deno- mination of hymefi, which ferves to exclude the air or water, and afford fome figns of chaftity. It is circular, excepting a fmall deficiency un- der the urethra, which yet is not always con- fcant, but fpreads itfelf very broadly below, to- wards the anus. This membrane, if not pre- vioufly injured by difeafe or violence, is broke in the firft congrefs 3 and, in length of time, its lacerated portions almofl difappear. §. 820. 29S Of the Pregnant Womh. §. 820. The fabric of the vagina is fome- what like that of the fkin, compofed of a firm, denfe or callous cuticle, covering a thick, white, nervous Ikin, in which, more efpecially at its end, appear flefhy fibres. Its internal furface is, in a great meafure, rough, befet with many callous warts, which, though hard, are fen- fible ; befides which, there are thin plates, ter- minated with a protuberant inclined edge, point- ing downward, fo as to form two principal rows, fpreading betwixt thofe warts ; and of thefe, the uppermoft are extended under the urethra, where they are larger, as the lower are incumbent on the anus. From each of thefe to the other are continued, on both fides, feveral rows of lelfer valve-like papilla;, va- rioufly infledied into arches, and which feem to be defigned for increafing the pleafure, and facilitating the expanfion when it is called for. It is furniflied with a proper mucus of its own, feparated from particular finulfes in feveral parts, but more efpecially in its pofterior and fmoother fide. §. 821. At the entrance of the vagina are prefixed two cutaneous produdions or appen- dages, called nympha, continued from the cutis of the clitoris, and from the glans itfelf of that part ; and thefe, being full of cellular fub- ftance in their middle, are of a turgefcent or difrendible fabric, jaggid and replenillied with fe- baceous glandules on each fide j fuch as arc alfo found in the folds of the prcepuce, belong- ing to the clitoris. Their ufe is principally to dired the urine, which flows betwixt them both Of the Pregnant Womh. 299 both from the urethra, that, in its defcent, it may be turned off from clinging to the body, in which office the nymphae are drawn toge- ther with a fort of eredion. Thefe membra- nous productions defcend from the cutaneous arch lurrounding the clitoris, which is a part extremely fenfible, and wonderfully influenced by titillation j for which it is made up, like the penis, of two cavernous bodies, arifing, in like manner, from the fame bones (§ 794 -)j afterwards conjoining together in one body, but without including any urethra. It is furnifhed wdth blood- veflels, nerves, and levator mufcles, like thofe of the penis (§. 794. )> like unto which the clitoris grows turgid and ereCt in the venereal congrcfs, but lefs in thofe who are very modefl:. §. 822, At the outer fides of the vagina, where the cutaneous lips are continued into large folds, to guard or defend the whole pudenda, there is a large furrounding plexus of veins, formed by the ultimate branches of the external hi^morrhoidal veins. This plexus, both from the right and left fide, are conjoined together with the middle plexus, in the upper part 'of the vagina, above the clitoris ; but a good deal of the fabric is here obfcure. Into thofe plexufles the blood impetuoufly flows, at the time of venereal irritation, fo as to ftraighten the vagina, and increafe the pleafure of bothfexes. To the fame purpofe alfo conduces the mufcle, termed ofii vaguue confri^or, which, ariflng on each lide from the fphinCler of the anus, and from within the tubercle of the os ifchium, covers 300 Of the 'Pregnant 'Womb. covers the vafcular plexus of the perineum, from whence it proceeds outward in the di- redlion of the labia externa, and is inferted into the crura clitoridis ; thus it feems to com- prefs the lateral venal plexuffes of the vagina, and that of the perineum, which are derived from the external hsmorrhoidals j whence it every way conduces to retard the return of the venal blood. ' §. 823. When a w^oman, invited either by moral love, or a luftful defire of pleafure, ad- mits the embraces of the male, it excites a con- vulhve conftridion and attrition of the very fenfible and tender parts, which lie within the contiguity of the external opening of the vagi- na, after the fame manner as we obferved be- fore of the male (§. 801.) ; by thefe means the return of the venal blood being fupprefied, the clitoris grows turgid and eredl, the nymphse fwell on each fide, as well as the venal plexus, which almofi; furrounds the whole vagina, fo as to raife the pleafure to the highefi: pitch ; in confequence of which there is expelled, by the mufcular force of the confiridlor (§. 822.), but not perpetually, a quantity of lubricating mu- cous liquor, of various kinds. The principal fountains of this are feated, at the firfl; beginning or opening of the urethra, where there are large mucous finufies, placed in the protuberant mar- gin of this uriniferous canal. Moreover, there are tw'oor three large mucous finuffes, which open thentfelves into the cavity of the vagina itfelf; and others at the fides of the urethra in the bottom of the finufies, which are formed by Of the T regnant Womb, 30 1 the membranous valves, falcated upward. Laftly, at the jfides of the vagina, betwixt the bottoms of the nymphas and the hymen, there is one opening, on each fide, from a very long dud: j which, defcending towards the anus, receives its mucus from a number of very fmall fol- licles. §. 824. But the fame adion which, by increa- ling the heights of pleafure, caufes a greater conflux of blood to the whole genital fyftem of the female (§. 551, &c.), occafions a much more important alteration in the interior parts. For the hot male femen, penetrating the ten- der and fenfible cavity of the uterus, which is itfelf now turgid with influent blood, does there excite, at the fame time, a turgefcence and diftenfion of the lateral tubes, which are very full of velfels, creeping betwixt their two coats ; and thefe tubes, thus copicufly filled and florid with the red blood, become ered and afcend, fo as to apply the ruffle or fingered opening of the tube to the ovary. In the truth of all thefe particular changes, we are con- firmed by difiedions of gravid or pregnant wo- men, under various circumftances, alfo from the comparative anatomy of brute animals, and from the appearances of the parts when dif- eafed, §. 825. But, in a female of ripe years, the ovary is extremely turgid, with a lymphatic fluid, which will harden like the white of an egg, and with which little bladders are diftended. Alfo, before the conception, there is generally formed, by degrees, a kind of yellow coagu- lum, ^02 Of the Pregnant Womb. lum, within Tome veficle of the ovary f§. 8 c as I have frequently feen, which fubftance in- creahng very much by degrees, the coat of the veficle difappears, and it changes into a hemi- fpherical yellow body [corpus luteum)^ fome- what like a bunch of currants ; which body is inwardly hollow, and includes in its cavity, as far as we can perceive, the very minute hollow membranes or eggs, which are to be the feats of future fcetus’s. The extremity of the tube, therefore, furrounding and compreffing the ovarium in the fervent congrefs, prelTes out and fwallows a mature ovum, from a filTure in the outer membrane, from whence it is continued down, by 'the pcriftaltic motion of the tube, to the uterus itfelf, which periftaltic motion be- gins from the firft point of contadl with the ovum, and urges the fame downward fuccef- fively to the opening into the fundus uteri* The truth of tliis appears from the perpetuity of the corpora lutea, which are never abient in prolific women, but always form a protube- rance j from the repeated and conftant obler- vation, of the number of fears or filTurcs in the pvarium, being always conformable to the number of foetulTes excluded by the mother; and however fmall the ovum is found in the tube, which is itfelf narrow, yet the entrance of it through the uterus is fo miuch narrower, that the veficle can fcarce pafs along that way with its figure entire. Yet we mufi; acknowledge, that the ovum was never truly obferved, included within its yellow calix, in palling the tube. §. 826. Of the Pregnant Womb. 303 §. 826. This conveyance of the ovum is not performed without great pleafure to the mo- ther, nor without an exquifite unrelatable fen- fation of the internal parts of the tube, threat- ening a fwoon or fainting fit to the future mo- ther. Thus, at length, a conception enfues, when the ovum is fo changed by the male fe- men, that the firft rudiments of an incipient foetus are therein begun j whether that be from a vermicle entering into the ovum, as a new inhabitant, or from the fpirituous part of the femen, exciting a new vital motion in the fluids of the ovum itfelf j for hitherto there are no obfervations, which countenance a previous de- lineation of the foetus in the ovum ; no fuch marks can be feen in the virgin ovum, and the foetus, which is produced from unlike parents, refembles the father more than the mother j alfo the ova, which are, in all re- fpe6ts, perfedt on the fide of the female, fo as to refemble thofe which are truly prolific, do, notwithftanding, always prove flierile, and bring forth nothing without the male femen. §. 827. It may be demanded, whether the feat of conception be in fome certain part of the uterus, to which experiments fhow, that the male femen is conveyed ? or whether the energy of the male femen impregnates the ovum, while it is yet lodged in the ovary j as would feem to follow from the examples of fcetufTes, found in and about the ovarium, and in the tube ? to which add the evident changes, that are pro- duced by pndific venery in the corpus luteum j and the anaiogy of the feathered kind, in which, after 304 0/ the Pregnant Womb. after the congrefs, there is but one ovum falls into the womb ; though, at the fame time, a great number are fcecundated in the ovary from the one hngle tread ; nor is the fmallnefs of the quantity, or fluggifhnefs of the motion ob- fervable in the male femen, any obiedlion to this fyftem, though fome may imagine from thence, that it is not able to penetrate fo far through fuch narrow tubes. For that the tubes themfelves are in a recent impregnation, re- plenilhed with the male femen, is evident even to demonftration or infpedtion, as well in man- kind as in brute animals. §. 828. After conception, we know certainly, that the uterus In brute animals, clofes itfelf ; and it mod probably does the fame in our own fpecies^ that fo the prepared and (lender ovum, together with the expected fruit or foetus, may not be loft, to the difappointment of nature in her intention. After the human ovum has lain fome days In the womb, we begin to learn itschanges more fenfibly. The ovum itfelf fends out, on all fides, fleecy foft branches from its including membrane, which is as yet fimple j thefe fleeces, inofculate and cohere with others of the fame form, belonging to the flocculent, exhaling and abforbing vefl'els of the uterus in- ternally (§. 805.). This adhefion of the ovum is made in all parts of the uterus, but more ef- pecially jn its thicker part, which lies betwixt the entrance of the tubes, commonly called the fundus. By this communication a thin ferous., humour, paffes from the villous arteries of -the uterus, into the receiving fmall veins ‘of the , ovum, Of the 'Pregnant Womb. 305 ovum, which is thereby nourifhed, together with its included foetus j but before this adhe- fion, it is either nouriihed by the matter it already contains, or elfe by fuch juices as it ab- forbs from the furrounding humour?. §. 829. At this time, in the ovum, there is a great proportion of a limpid watery liquor, which, like the white of an egg, hardens by the heat of fire, or a mixture with alcohol ; and now the invifible foetus firft appears, with a very great head, a fmall (lender body, and as yet with- out limbs, fixed by a very broad flat navel- ftring to the obtufe end of the ovum. From hence forward the foetus continually increafes, as well as the ovum, but in a variable, unequal proportion ; for while the arterial ferum is con- veyed by more open paflages into the fmaller veffels of the ovum, the foetus itfelf grows the fafteft; becaufe now the greateftpart of its nou- rifhment feems to pafs, through the ample and open umbilical vein. At the fame time the ovum itfelf alfo grows, but lefs in proportion ; and the waters, which it includes, gradually diminifh from their firft proportion, in refpecft to the bulk of the foetus. The fleecy pro- du6lions of the veflels from the ovum are gra- dually fpread over with a continued membrane, w^hich makes the chorion ; betwixt which and the amnios they are intercepted ; of thefe the greater part difappear below, or elfe terminate in the chorion, and only thofe which fprout out from the obtufe end of the ovum, take root,; or increafe fo as to form a round circum- fcribed placenta or cake. -^ VoL. II. X §. 830. 306 Of the T regnant Womb. §. 830. Such is the appearance of the ovum, as we have here defcribed it, commonly in the fecond month ; from whence forward it changes only byincreafing in bulk. That part of the ovum next the fundus uteri is commonly uppermoft, making about a third of its whole furface, in form of a flat round difh or plate j fucculent and full of protuberances, but throughout perfedtly vafcular, uniting and interlocking with other tubercles of the fame kind, and with a thin cellular fabric of the uterus itfelf ; which being without fat, accurately colledls and conjoins the ftnall veflTels of the uterus, as exhaling arteries, fo as to correfpond infeparably with the inhaling or abforbing veins of the placenta, and the wide opening veins of this laft to the veins of the uterus. This communication of the veflTels, ap- pears evident, from the lofs of blood which follows from a reparation of the placenta in a mifcarriage ; and from the blood of the foetus being exhaufted from an hemorrhage in the mother; from hemorrhages that enfue from the navel-ilring, fo as to kill the mother when the placenta has been left adhering to the ute- rus ; and laflily, from the paflTage of water, quickfilver, tallow, or wax, injedled from the uterine arteries of the mother into the veflcls of the placenta, as is confirmed by the moft faith- ful obfervations ; to this add the ceflTation of the menflirual flux in the mother, which quan- tity of blood mufl: of necefliity be taken up by fome other part, viz. the foetus. §. 831. The remaining unconnected part of the ovum, and likewife the furface of the pla- centa. Of the Pregnant Womb. 307 centa, are covered by an external villous and fleecy membrane, full of pores and fmall velTels, of a reticular fabric, eafily lacerable, fo as to refemble a fine placenta, and is called the cho- rion. But even this is, in fome meafure, con- nected to the furface of the uterus, by very fmall fleecy veflTels, but lefs and fofter than the veffels of the placenta. But then thefe have inwardly a true folid membrane, fpread under them as a foundation, which you may either reckon an inner plate of the chorion, or a fe- cond diftinCt covering of the foetus. §. 832. The innermofl: coat of the foetus, which is called amnios^ is a watery pellucid membrane, very rarely fpread with any confpi- cuous veffels, which yet it has had under my obfervation in an human fubjeCt ; extremely fmooth, and in all parts alike ; alfo extended under the placenta with the former, the fur- face of which is every way in contaCl with the waters. With the outer plate of the chorion the cellular fubftance is conjoined. §. 833. The nourifliment of the foetus from the beginning to the end of the conception, is without doubt conveyed to it through the um- bilical vein. This gathers its roots from the exhaling veffels of the uterus (§. 810.), and has manifefl; communications by fome roots with the umbilical artery, from whence it in part rifes, and meeting together in a large trunk, it is twilled in a circular manner through a num- ber of folds to a fufficient length, that may al- low of a free motion ; and in this courfe it is furrounded with a cellular fubftance full of X 2 mucus, 308 Of the V regnant Womb. mucus, diftingulfhed by three partitions, and the membrane, which is continued both to the amnios and peritoneum of the foetus ; and af- ter forming fome protuberances, it enters through the navel, in an arch made by a part- ing of the Ikin and abdominal mufcles, and goes on through a proper finus of the liver (§. 672.), into which the fmaller portion of the blood that it conveys is poured through the {lender dudlus venofus, into the vena cava, feated in the pofte- rior foffa of the liver ; but the greater part of its blood goes through the large hepatic branches, which conflantly arife from it fulcus, and re- main even in the adult (§. 674.) i but it goes thence to the heart by the continuous branches of the vena cava (§. 6^6.). It may be de- manded, whether the circulation be reverfed in the liver of the feetus ? whether the finus or left branch of the vena portarum be not a part of the umbilical vein itfelf, fo as to convey the blood by its branches from the placenta to the cava, while only the right branch (§. 664.) conveys the blood of the mefentery and fpleen through the liver ? and whether this motion is allowable from the different and almoff con- trary direction of the blood from the umbilical vein, and that brought from the mefentery, fince there is no feptum to diflinguifh betwixt the umbilical vein. §. 834. But this is not all the ufe of the placenta ; for the foetus fends great part of its blood again into the fubftance thereof, by two large umbilical arteries, which are conti- nued on in the diredlion of the aorta; and af- ter Of the Pregnant Womb. 309 ter giving fome flender twigs to the femorals> with ftill fmaller arteries into the pelvis, they af- cend reflected back with the bladder on each fide of it, furrounded with the cellular plate of the peritonaeum, with fome fibres fpreading to them from the bladder and ureter, in which manner they proceed on the outfide of the pe- ritonaeum into the cord at the navel, in which pafling alternately in a ftreight and contorted courfe, they form various twiftings or wind- ings, fomewhat (harper than thofe of the vein which they play round ; in which manner they at laft arrive at the placenta, whofe fubftance is entirely made up of their branches, in con- jundtion with thofe of their correfponding vein. By thefe branches the blood feems to pafs out through the minute arteries of the placenta into the bibulous veins of the maternal uterus, that after undergoing the adlion of the lungs by the mother’s refpiration, it may return again in an improved ft ate to the foetus : for what other reafon can be affigned for fuch large arteries, which carry oif above a third part of the blood in the foetus, to the placenta and womb of the mother ? §. 835. But it will perhaps be demanded, whether the foetus is not nouriftied by the mouth likewife ? whether it does not drink of the lymphatic liquor contained in the cavity of the amnios, which is coagulable like the nutri- tious ferum, and in the middle of which the foetus fwims ? whether this opinion is not in fome meafure confirmed, by the analogy of chickens, which are under a necefiity of being X 3 nou- 3 1 o Of the Pregnant Womb. nourlfhed, from the contents of the egg only ; to which add the abfence of a navel- firing in fome foetus’s, the quantity of meconium filling the large, and part of the fmall inteftines ; the fimilitude of the liquor found in the cavity of the ftomach, to that which fills the amnios, the proportionable decreafe of the liquor amnii, as the foetus enlarges ; and finally, the gluti- nous threads which are found continued from the amnios, through the mouth and gula, into the ftomach of the foetus ? again, what are the fountains or fprings from whence this lymph of the amnios flows ? whether it tranfcends through certain pores from the fucculent cho- rion, which is itfelf fupplied from the uterus ? It muft be confeffed, that thefe enquiries la- bour under obfcurities on all fides ; notwith- ftanding which, there feems more probability for them than otherwife, fince the liquor is of a nutritious kind, derived from the uterus. §. 836. All the excremental faeces, which are colledted in the foetus during the whole time of its refidence in the womb, amount to no great quantity, as they are the remains of fuch thin nutritious juices, percolated through the fmalleft veflbls of the uterus. I frequently pbferve, that the bladder is empty in the foetus, on account of the perpetual warmth with which it is cherifhed ; for in like manner we fee, that the external heat in adults will greatly diminifti the fecretion of urine. However, there is ge- nerally fome quantity of urine, colledled in a very long conical bladder, and the reft is pro- bably transferred through the kidneys, of the mother, Of the Pregnant Womb. 3 1 1 mother. But in the cavity of the inteftines, there is colleded together a large quantity of a dark green pulp, which may poffibly be the remains of the bile, and other exhaling juices, like the feculent remains, which are fometimes left in other cavities of the body, that are filled with exhaling juices ; and fuch as I have fometimes obferved, even in the vaginal coat of the tefticle. §. 837. It may then be demanded, whether there is any allantois ? fince it is certain, that there pafies out from the top of the bladder, a du( 51 :, which is at firft broad, covered by the longitudinal fibres of the bladder, as with a capfule ; and afterwards when thofe fibres have departed from each other, they are continued thin, but hollow, for a confiderable way over the umbilical cord, from whence they have been traced by Swammerdam and Dr. Hale, and other eminent anatomifts, to their expan- fion at the placenta, under this denomination ? whether this, although it be not yet evident in the human fpecies, is not confirmed by the analogy of brute animal, which have both an urachus, and an allantois ? But as for any proper recep- tacle, continuous with the hollow uracus, • it either has not yet been obferved with fufficient certainty, or elfe the experiment has not been often enough repeated, to become general in the human fpecies ; for we know, that in the human foetus, the urine is but feparated in a very fmall quantity j but it perhaps may be no improbable conjecture, that fome portion of the urine is conveyed to a certain extent into the funiculus Limbilicalis, and there be transfufed into X 4 the 3 1 2 Of the Pregnant Womb. the fpungy cellular fabric that furrounds it. But then this can take up but a fmall fpace, ter- minating in the funis, and hardly ever feems to reach as far as the placenta, unlefs in ex- traordinary cafes. §. 838. In the mean time the foetus (§. 829.) continues to advance in growth, the limbs by degrees fprout from the trunk, under the form of tubercles, and the other out-works of the human fabricature are by degrees beautifully finifhed, and added to the reft in a manner not here to be at large deferibed, as indeed it has not been as yet by anotamifts in general. Thus we fee that in the anthropogenefis, the head or encephalon, and its appendages, are firfl formed and compleated j then the vifeera of the bread:, and afterward the abdomen, and its contents; but laflly, the limbs, with the other extreme parts. But in the thorax of the foetus, we obferve a good deal of difference in the organs from thofe of an adult. §. ”^39. The firft of thefe differences is in the thymus, a large conglobate glandule, but of a foft loofe texture, compofed of a great many lobules or fmall portions, which are colleded together into two larger, and connedled one to another by a good deal of cellular fubfiance. It is extended over the bottom of the neck, and through a large part of the mediaftinura, being altogether filled with a whitifh whey- like liquor ; but this body being compreffed by the repeated expanfions of the lungs, is in adults beat together with the pulfations of the fubjacent aorta, which enlarges after the birth; by thefe means Of the Pregnant Womb. 313 means there are at length very little remains of this gland to be feen. It will perhaps be de- manded, what is the ufe of this glandule j or of its liquor ? We are as yet indeed unac- quainted with thefe particulars j but we ob- ferve alfo, that all the other glandules of the foetus, more eTpecially of the conglobate kind, do in their bulk greatly exceed thofe of adults. §. 840. The cavity of the bread is mort in the foetus, and greatly deprefled by the enor- mous bulk of the liver j the lungs are fmall in proportion to the heart, and fo folid as to fink in water, if they are every way excluded from taking the atmofphere into their fpungy fub- ftance, in making the experiment. Since there- fore the like quantity of blood (§ 292, 297.), which pafies the lungs by refpiration in adults, cannot be tranfmitted through the unadlive lungs of the foetus, who has no refpiration 5 there are therefore other ways prepared in the foetus, by which the major part of the blood can pafs diredlly into the aorta, from the lower cava and umbilical vein, without entering the lungs. And firfi: the feptum betwixt the right and left auricle, conjoining them together, is perfo- rated with a broad oval foramen j through which the blood coming from the abdomen, and a little direded or repelled by the valvular fides of the right auricle, flows in a full dream into the cavity of the left auricle. But it is by degrees that the membranes of each flnus de- part from each other, upward and backward, above the oval foramen into the pulmonary finus^. where they are connected on each fide above, -514 Pregnant Womb. above, by feveral orders of fibres, which belovf are palmated or like fingers, fo as to clofe up at firfi: a fmall part, and afterwards a greater part of this foramen, fo as to leave only a fmall oval portion of it at liberty; which lies pervious, betwixt the round margin of the faid oval fora- men, and the increafing valve, making in the ma- ture foetus, about a fifteenth part of the area or capacity of the mouth of the vena cava. §. 841. That the blood takes this courfe in the foetus, and that it does not on the contrary flow from the finus of the left to that of the right auricle, is evident, from all manner of experiments and obfervations. For, firfi:, the column of blood in the right finus, is of all the largeft ; and as it is the returning one from the whole body, cannot be exceeded by any other ; but the left auricle has fo much lefs blood in proportion than that of the right, in- afmuch as part of it flows through the du£t or canalis arteriofus into the aorto, whence its contents will be much lefs than that of the right auricle : moreover, the valve of the oval foramen in a mature foetus, is fo large, and placed fo much to the left of the mufcular arch or ifthrnus (§. 840.), that when it is im- pelled by the blood from the left fide, the valve, like a palat or fh utter, clofes up the foramen ; but being impelled from the right fide, it rea- dily gives w'ay fo as eafily to tranfmit either blood or flatus. §. 842. Moreover, there is but a fmall por- tion of the fame blood, which firfi entered the right auricle and ventricle of the heart, that takes of the "Pregnant Womb. 315 takes its courfe through the lungs ; for the pul- monary artery, being in the foetus much larger than the aorta, is dire< 3 ’ly continued into the latter by an open paffage, called the dudtus ar- teriofus ; which is larger than the light of both the pulmonary branches together, and enters that part of the aorta which comes firft in con- tact; with the fpine, under its left fubclavian branch : by which means it transfers more than half the blood to the defcending aortaj which muft otherwife have paffed through the left auricle and ventricle into the afcending branches of the aorta j and this is the reafon why the aorta in the foetus is fo fmall at its coming out from the heart. By this mechanifm an over- charge of blood is turned off from the lungs, by direding a great part of that fluid in a flreight courfe to the umbilical arteries. §. 843. As the foetus grows larger, fo the uterus increafes proportionably j the ferpentine arteries of which it is compofed, being ex- tended by the impelled blood, and ftretched into a more dired courfe. Thus its thicknefs continues the fame, becaufe the greater quan- tity of blood and dilatation of the arteries and veins, make up for the extenuation of the folid cellular and fibrous fubftances. Cut more efpe- cially the fundus, or upper part of the womb, increafes beyond the reft; fo that by dilating above the tubes, thefe laft feem thus to de- fcend from the middle of the uterus, which now by degrees goes out of the pelvis, even as high as the colon and ftomach itfelf, fo as to ccmprefs all the. abdominal vifcera, more efpe- 3t6 Of the Pregnant Womb. efpecially the bladder and redtum. During this whole time of the uterine geftatlon, the os tincce is never perfectly clofed or fhut together, but only ftoped up and defended from the air by thick mucus from the finufes, and perhaps from the veficles, which are feated in the cervix uteri. Moreover, the cervix or neck of the womb itfelf, yields to the extenfion of its body 3 fo as to become perfedlly fhort, and form a broad hat opening, of no length; which, to- wards the time of delivery, is always more or lefs relaxed and gaping. As thefe matters ad- vance, the fmtus, which in the firfi: months had no certain fituation, being now grown to a confiderable bulk, is about the middle of the time of geftation, folded together into a globe, in fuch a manner, that the head lies betwixt the knees; and being the heavier part, it fubfides by degrees, more and more towards the cervix uteri. §. 844. This alteration and advancement of the foetus, excites at firft uncertain commoti- ons, by which the lides of the irritated uterus endeavour to difengage themfelves ; and at length, towards the conclufion of the ninth fo- lar month, when both the weight and reft- Icfsnefs of the foetus in often kicking the womb, become now intolerable, the head of the foetus is by the re-adlion of the uterus and ab- domen, impacted into the bowl of the pelvis, fo as to give the mother great uneafmefs, as if a quantity of fceces were collefted for exclu- hon in the redlum ; in confequence of which pain, of the Pregnant Womb. 317 pain, the mother is obliged to throw or ftrain towards delivery. §. 845. The tenefmus thus increahng till it is no longer tolerable, the mother ufes all her efforts by very deep infpirations, which prefs downwards the uterus and vifcera of the abdomen (§. 745.) i and at the fame time the womb itfelf, by its contradlile vital force, now increafed by the ftimulus, conftringes itfelf fo powerfully about the foetus, as fometimes to exclude it, without further efforts from the mo- ther. Here then the amnios, filled-out with the waters, is firil protruded vertically, before the head of the foetus, fo as to dilate the os inter- num uteri i in which, the membranes being by degrees extenuated and dilated, ealily break, and pour out their waters, which lubricate the paffages, and relax all the parts of the vagina. The naked head of the foetus now prefents, na- turally with the face to the os facrum 3 direct- ed that way by its weight : and being urged forward, like a wedge or cone it further dilates the os uteri ; till at length, by the more power- ful efforts of the mother, which often loofen the bones of the pubis in young women, the head is thruft out through the diftraCtile vagi- na, with intolerable pain to the mother, and an univerfal tremor of body 3 and if none of the bones of the pelvis happen to prefs une- qually, the infant eafily advances, and is foon delivered into the world. §. 846. The placenta or after-burthen of the foetus, connected with the fundus uteri (§. 810,), is, in the next place, feparated from the womb, 7 3i8 Of the F regnant Womb. womb j without much difficulty in a mature birth, partly by the weaker throes of the mo- ther, and partly by the extradling force of the deliverer ; by which the fleecy or villous fur- face of the placenta being withdrawn from that of the womb, is immediately followed with a confiderable flow of blood , and thus is the mother delivered from the fecundines or after-birth. The umbilical cord of the foetus is next tied with a ligature before it is cut off ; for it cannot be left open, without danger of a fatal haemorrhage. Thus the umbilical vein is deprived or cut off from all the fupplies of blood which it ufed to receive, and at the fame time an infuperable obftacle is oppofed to the exportation, that was made by the arteries of the fame name. §. 847. The uterus, which hitherto had been difiended beyond imagination, now con- trafts itfelf, by the elaftic pd^er of its fibres j (§. 804.) fo fuddenly and powerfullv, as often to catch and embarrafs the hand of the deli- verer, and frequently retain the placenta, if it be not foon loofened and withdrawn. Ey this contradlion of the womb, the bleeding vefiels are compreffed, no lefs than by the contradlion of their own coats ; whence the large quantity of blood that was collected in the uterine fub- ftance abundantly flows out, under the denomi- nation of the lochia ; at firft a mere gore, but afterwards their purple colour changes by degrees to that of the yellow ferum ; and as the open- ings of the veffels more contract themfelves, they at length become of a whitifli or 4 wheyiih V Of the Pregnant Womb. 319 wheylfh complexion : and then, the ample wound or excoriation of the uterus foon recovers a new epithelium or cuticle, and fhrinks up to a bulk not much exceeding that of the primi- tive virgin uterus. §. 848. But after two or three days are elapfed from the birth, when the lochial dif- charge has almofl: fpent itfelf, the breafts be- gin to fwell confiderably, and their duds, which in the time of geftation often diftil a little thin ferum from the nipple, become now very tur- gid, with a fweet liquor j which is at firft thin or like whey, but is foon after followed by the thicker chyle itfelf, not much altered, under the denomination of milk; namely, a white, fweetifh and thick liquor, very much refem- bling that of the chyle, and replete with an effential fait, like that of fugar, which fpon- taneoufly turns four; it has alfo a volatile and fomewhat odorous vapour, a good deal of fat or oily parts, a larger portion of a white crafla- mentum or cheefy curd, and hill more of a diluting water ; and again in the crafTamentum, are contained parts of a more earthy, alcalef- cent or animal nature. But when the chyle is once changed into ferum, by faffing fix or more hours after a meal, the milk becomes brack- ifh, alcalefcent, and difpleafing to the infant. As the chyle, fo the milk frequently retains the nature of the aliments and medicines taken into the ftomach. The caufe of this increafed fecretion in the breads, feems owing to revul- fion, Jn confequence of the plentiful uterine ' fecretion being fuppreffed, by which the foetus 320 Of the Pregnant Womb. was nourifhed ; in the fame manner as a diarr» Jiaea is fupprefled by increafing the perfpiration, or the reverfe. For it has been obferved, that true milk will fometimes make its way through other parts, befides the breafts, and efcape through wounds, &c. but the inofculations betwixt the mammary and epigaftric arteries, though true, are fo fmall, that they can have but a very little (hare in this account. §. 849. The breafts are made up with a ve- ry large quantity of foft furrounding cellular fat, of a white colour ; and conglomerate glan- dules, of a convex figure, affembled into bunches fomewhat round and hard, of a red- difh blue colour, outwardly furrounded and connedted together by a firm web of the cel- lular fubftance. To thefe glandules a great number of blood- vefiTels are diftributed from the internal mammaries, from the external veffels of the thorax, and fometimes from thofe of the fhoulders, all which inofculate together around the nipple. The nerves of this conglo- merate gland are both large and numerous, like thofe of the more fenfible cutaneous parts, being derived from the intcrcoftals. §. 850. From the middle of the glandules of the breaft, an infinite number of fmall dudfs or roots arife, very ftender, foft, white, and dilatable, which run together into 'arger, from all fid es to the middle of the nipple, which they perforate round its margin, in a circular figure, after emerging t!', rough the rout of the_ papilla or nipple 3 tor by thi'^ d- ^ ‘Omioation we call a cavernous or 'tpungy protuberant • ..v'ddy. Of the Pregkant iVomb'. 32 1 body, into which the blood may pafs out from its veitels, fo as to caufe a kind of turgefcence or erection, v/ith a fomewhat (imilar fenfation, as in the clitoris or periisi Through this pa- pilla open about twenty or more of the exCre» tory duds from the bitaft, called ladiferous, none of which inofculate or join with the other, but are greatly contracted at their open- ing in the nipple, to what thfey were in the bread ; and thel'e, ill a loofe or flaccid date of the nipplo, are comprefled, w'rinkled, andcdl- lapfed together j but when the nipple is diftend- ed by fucking, or any kind of titillation, they become ftreight and open, with patulent moUths, lurking betwixt the wrinkles or in- cifures of the cutis and cuticula. This papilla or nipple is furrounded by a circle, planted with febaceous fmall glandules, which defend the tender fkin againfl: the repeated attrition and faliva of the fucking infant. §. 851. Thus the infant is naturally pro- vided with its flrfl; food, which by infliinCt it Ivell knows ho# to receive, although it is as yet a ftranger to all the other offices of human life. Iris remarkable with how much ferven- cy the young gaefl; caufes the nipple to fweli by gentle vellications ; the lips are preffed clcfe to the breafl, that no air may enter betwixt, at the fame time the inTpiration is deep, and a fpace formed in the back part of the mouth, in which the air is more dilated or tariffed j and thus, by the preffure of the external air, joined with that from the lips of the infant, f the milk is urged from the bread through the .VoL. II. Y nipple. 3 2 2 Of the Pregnant Womh. nipple, in which it would otherwife be col- lected in fo great a quantity, as fomctimes t6 diftil fpontaneoufly, from the force of the cir- culation ; whence it is in this manner more eafily drawn, as nouri(hment, by the infant. The firfl milk, which is like whey, termed coloftra, loofens the tender bowels, and purges out the meconium (§. 836.), to the great ad- vantage of the infant. Yet it is alfo obfervable, the lactiferous duCts are fo open, that when the nipples of the bread are didended by titilla- tiori, and a greater quantity of blood fent into the breads, they have yielded milk to the fuck- ing infant, even from virgins, fometimes from old women, and rarely from the breads of men. §. 852. But great changes now happen to the little new inhabitant of our world 5 and fird, its dormant and unaCtive uterine date im- mediately changes in the refpiration, which it endeavours to exert, even before it is wtU feC at liberty from the vagina of the mother, being probably excited thereto from the pain or an- guidi it feels by the various agitations of the deliverer, who is immediately faluted by its cries. At fird, therefore, a portion of the air is admitted into the lungs, which are as yet fmall and full of moid vapours, but being di- lated from the air, change from a fmall denfe body^ finking even in fait water, into a light fpungy floating fabric, extended to a confi- derable bulk, with air. Now, therefore, the blood pafles more eafily into the enlarged and loofe fabric of the lungs (§. 292.); in confe- quence of which, a large portion of the blood Of the 'Pregnant Womb'. 32^ tkat went before from the pulmonary artery, thro’ the canalis arteriofus, into the aorta, goes now into and through the lungs themfelves, by the other branches of the faid pulmonary ar- tery. And fo much the more is the arterial dud: or canal deferted, inafmuch as made a newobftacle to the defcent of the blood into the abdomen, from the ligature of the umbilical arteries ; whence the blood of the defcending aorta cannot thus go to the lower parts, but by the fame force, with which it dilates, all the arteries of the pelvis and lower extremities. Finally, as the lungs now receive more blood, fo the aorta itfelf receives a greater quantity, and with greater force likewife from the heart ^ whereupon the intermediate canal, betwixt the protuberant part of the aorta and pulmonary artery, clofes up or darinks to fuch a degree, that, in adults, it is not only an empty ligament, but likewife of very little length. This courfe of the blood, therefore, is foon aboliflied, or (hut up commonly in about the compafs of a year. §.855. In the like manner alfo, the foramen ovale is, from the fame caufes, gradually clofed up. For when the way is rendered more free and pervious into the lungs, it will likewife be more tree into the ritrht fide of the heart; whence the blood, both of the afcendinti and defcend- ing cava, will flow thither more plentifully, as it is invited by the more lax pulmonary artery, into which it will rather move on, than through ,the oblique narrow foramen of the feptum. Again, the umbilical vein, being now almoft y 2. defti- 324 Of the Pregnant Womb. deftitutc of any fupply with blood from the li- gature of the navel (§. 846.), lefs blood will from thence flow into the lower cava, and con-* fequently the preflhre, on the right fide, againfl: the oval foramen will be diminifhed, by which means the blood of the upper cava^ being turned off by the iflhmus, will be fcarce able to pe- netrate the obliquity of the foramen ovale. Thence again, as more blood is derived through the lungs into the left finus and auricle, its greater dilatation and extenfion will ftrain the little horns of the oval valve, fo as to draw up and prefs the valve, together with the iflhmus, whereby it is extended fo far, as wholly to fliut up the opening in the mature infant, while, at the lame time, the blood, within the left finus, props up the faid valve, fo as to fuftain the im- pulfe of the bloody on the other fide, wdthin the right finus. Thus the foramen ovale clofes up by degrees, as the upper margin of the valve forms a concretion to the pofterior face of the iflhmus. But this is performed very flow- ly, infomuch, that frequently, in an advanced age, there will be fome fmall aperture or tube ftill remaining ; and where there is none of this tube, yet there are the remains of one, as a kind of finus, hollow to the left fide, that makes a tube opening upward to the right fide, and blind or doled to the left. §. 854. The umbilical vein, being deprived of blood, foon dofes up. The blood of the vena portarum, having no oppofition from that which formerly flowed through the umbilicai vein, occupies the left finus and curve of the iimbi-^ Of the Pregnant Womb. 325 ^imbilical foffa (§. 674.), and fends Its blood through thofe branches, by which that of the umbilical Vein before paffed. Thence the dudlus venofus, being neglefted, (brinks up and clofes, by the new compreiFure which the defcend- ing diaphragm makes, upon the liver by in- fpiration ; and by which the left lobe is prelTed towards the lobule, and perhaps too from the obtufe angle which the venal dudt makes with the left finus of the vena portarum j for it is certainly firfi: clofed in that part which lies next the vena portarum. §. 855. The umbilical arteries are alfo clofed up from the fame caufes, as ocher arteries ufu- ally are after a ligature, when fome of the blood, being, at the fame time, compacted into a polypus, fills up the blind void part, while the other bloqd, flowing above, whofe impulfe was fuftained by the refilling membranes, fpreads itfelf through the adjacent lefs refilling branches, which are thereby rendered more open or diverging. Nor do I think, we ought to negle£l the force of the abdominal mufcles towards this effedl, by which thofe arteries are comprelfed againft the full abdornen in each re- Ipiration 3 and again, the very acute angle, in which the umbilicalis goes olF from the iliac artery, now becomes a curve, by defeending with the fides of the bladder, and is then di- rectly extended into an acute fold, which the thighs make with the body of the foetus. Thus the capacity of thefe arteries is foon Ihut up, leav- ing only a fmall tube, that gives palTage into two pr three arteries of the bladder. The urachus, be- Y 3 ing 326 OJ the Pregnant Womb. ing iikcwife a very thin tube, extended perpen- dicularly upvv'ard from the bladder, is, there- fore, eafily clofed up j fo that the contents of the bladder make no endeavours to pafs that way, finding a ready out-let by the defcending urethra. §. 856. From the like caufes the bulk of the liver itfelf is lelfened, and, by degrees, con- tradts itfelf within the capacity of the ribs ; in the mean time the inteftina craffa, from the flen- der condition in which they are obferved in the fretus, dilate to a conliderable diameter, and the (tomach itfelf is gradually elongated ; the large convexity of the caecum forms itfelf by the force of the faeces, preffing perpendicularly downward to the right fide of the vermicular appendix j and the lower limbs are likewife con- fiderably enlarged by the return of the blood, fent back from the umbilical arteries now tied ; and, by degrees, all the other changes are made, by which a feetus infenfibly advances to the nature and perfedtion of an adult perfon. §. 857. It will, perhaps, be demanded, by what caufe the parts of the foetus are thus fuc- ceffively built up ? whether this be the employ- ment of the mind or aniina ? we anfwer, that this does not feem an adequate caufe, being both ignorant of herfelf, and incapable of fore- feeing the future ends or purpofes, for which the feveral organs and their adlions are to be employed, by a juft mechanifm of the feveral rnembers in the feetus. Or it will he queried, whether the hrft rudiments or filaments, being fontaiiKd either in the ovum of the mother, or of the 'Pregnant Womh. 327 or in the animalcule of the rpale femen, are only afterwards dlfplayed, and filled out, by a more plentiful flow of juices ? for this, we have neither any fuch delineation demonflrable in the female ovum (§. ^20 ), nor in the animal- cule of the male femen (|. 7^8.). Or whe- ther, in confequence of the power of attrac- tion, by which nature performs all her other operations, the vifcid liquor of the ovum, al- tered by the femen, does not firfl: run together into a thread, which, under unknown circum- flances, increafes to a web of fibres, thofe into membranes, membranes inp veffels, and all thefe again into mufcles, which, at length, condenfe into bones, and make all the limbs of the body ? we mufl: give it, as our opinion, that this feems to be the mofl probable. But you will fay, wh^t can be the wife director of fuch a conftant, fuch a curious, and fuch a juft ftrudture, in fo great a variety of parts, and to fuch a number of particular ufes ? we anfwer, that it is doubtlefs the fame ever-adting and per- rnanent laws of the wife creator, by which freezing fpicula, chryftals of falts, the particles of mineral ores, the earthy globules of ftones, and the fandy glebes of gems or chryftals, are fo elegantly or geometrically conftrudled; by which the fine duft of mofles, and filaments of the flax or cotton, or the jelly of the fungous tribes, with the different juices of plants and their parts, are varioufly modulated : the fame power, under various circumftances, certainly ordains the unorganifed parts of fuitable matter into the tubular webs and fibres of vegetables, the glue Y 4 of 328 Of the P regnant Womb . of the more Ample infed; and fliell-animals, and the earthy ftamina of the blood and finer juices of the more perfeft animals, into fuch various filaments, cellular webs, and vafcular mem- branes, &c. as can be only the efFeft of definite la\ys, operating on the fame kind ol mi table matter, and under a variety of circumftjinces or conditions perfectly fiinilar. Need we go far- ther for a proof of this, than the fucceffive germination of the vifcera and limbs in a foetus ; in which, as in the polype, we fee the upper and lower extremities fprout infenfibly, not as threads, but equally, from tubercles, which (like trees) only grow in length, in proportion as they increafe in thicknefs, and are undequally dilated ? confider, if the fucceffive formation of the heart, out of a Angle tube, in a foetus or chick, ‘afterwards curioufly complicated (§. 78B.), and then, by degrees, fhielde'd within a craticle of the ribs and breaft, be not enough to turn the balance in this enquiry j rnore ef- pecially if you join a c'lofe attention to the fe- ries of the growth in plants, in polype infects, in chickens of the feathered tribe, and in the fcetuffies of our own fpecies, leifurely compared together ? whether the time of geftation and delivery are confined to a limited fpace r gene- rally fo as hardly ever to exceed the eleventh, or to fall within the beginning of the fixtli pionth, and the foetus furvive, as we learn by repeated obfervations, collected from all quar- ters.--— Whether the blemiffies or uterine de- formities of the foetus ffiew any confirudive power or faculty of the mind over the body ? Of the Pregnant Womb. 329 yjt neither knpw of any pafTages, by which the mind of the mother can diredt its operation to the body of the foetus, nor of any matter it can fend to effedl fuch a power, nor, in her- felf, has fhe any impullive power, or any cori- fcientious knowledge of her own or the infant’s being, much lefs any conftructive wifdom or power (§. 562.) : and in flaort, moil; of the inftances are either trifling, unjuftly related, or elfe mere fuperficial cutaneous affedlions, fuch as may arife from fomc fmall external injury or flimulus, which the weak mother afterwards afcribes to fome fright or notable accident, fhe can recolledt to happen in her pregnancy. But then, from whence arife monflers ? whether are they from a commixture of foetufles, half perfedl t pr were they originally formed, as we fee them excluded ? we are rather perfuaded to believe the former, from the various cohe- fions obferved in the hearts of ill-formed fce- tufles, which is a part not to be injured with- out fatal confequences ; and from the two in- teftinal trails, cohering together upwards with diflinil tubes, throughout their courfe in dou- ble-bodied fcetuflTes, and in a very conflant re- gular order : to which add the new and unu- fual parts formed to fome particular ufes of a monftrous fcetus, and the double or fuperfiuous parts, which are Angle in a welhformed foetus. . — Whether fuperfcetation be poffibie, when the clofure of the os uteri, the Ihortnefs of the pendulous tubes to embrace the ovary, and the previous fullnefs of the womb, with its ovum, ^re repugnant ? that fuperfcetation may happen -in 330 F regnant Womb. in the two firft months, is certain, while th^ womb is, in a manner, but half full In its fore' part ; whence a withered Ikeleton or clay-like fcetus is fometimes lirft excluded j and an healthy found infant is thus brought Into the world fome weeks or months after a former, that continues healthy and living. What are the bounds of foe- cundity in the human fpecies ? for a woman to bring four at a birth, is very rare ; though there are two or three inftance recorded of five. — t- What are the caufes of the pica^ longings or vi- tiated appetites of pregnant women ? one caufe may be the naufea, excited in the fenfitive fto- mach, by the abforbed femen of the male,fpread- ing, in the firft months, withthe blood (§ 790.): afterwards the fame nervous organ may be va- rioully affeded by compreffure from the womb, and the retained menfes Other caufes may be added, from an idle imagination, fruitful in foul ideas. [Whether the corpus luteum is full of fucculent organic particles, which combine with others of the fame kind in the virile femen, to form a new animal ? but the corpus luteum is not a caufe, but an effed: of impregnation j lince it is not to be found in the virgin ova, only it is vifible after the firft conception, nor are the juices thereof different from thofe in other parts of the body.] NOSO- 33 * NOSOLOGY: O R, BRIEF DIRECTIONS FOR THE K N O W L E D G E and C U R’E O F T H E Principal Diseases, incident to the H UMAN Body, before defcribed. §. I. W ^ROM the phyfiological accounts, we have before given, of the hu- ■ ^ man body, it appears to have been originally a gelatinous or unorga- nized liquid, lodged in the feminal fluids of the male, and within the female ovum; in which lafl:, by that mutual power of acceflion, feen in all nature, which is directed by the hand of omnipotency, the faid fluids, by incu- bation in the ovary and womb, do there, by a gradually increafed cohefion, flioot out into a web 332 Relaxation. web of elaftic threads (§. i 6 .), which, by de= grees, is formed, one part into a vafcular and nervous fyftem, fucceffively ramified or ex- tended from their two fources, the heart and encepnalon ; and then the other part, keeping its primitive cubweb-like fabric, continues in- terfpsrfed amongli the former as a cement, called cellular fubftance, to fuftain and keep them within due bounds, without hindering their re- fpedtive actions or motions. Since then it is evident, that the animal elements, which are a fubtle cretaceous earth and glue, or jelly, run firfi; into filaments, feveral of which, by fome unknown mechanifms (§. 6 .), acquire a mafcular or motive faculty, from whence all the organical fluids of combined globules, ei- ther pellucid in the nerves and lymphatics, or red in the blood-veflels, are fubfequently form- ed : it is from thence evident, that the bafis of pathology, no lefs than that of phyfiology, muft be derived from the prior and moft Ample folids, and their combinations ; to the difeafed or healthy ftate of which, the fluids, which they make and move, are univerfally conform- able. But we except from hence the effedls of thofe contagious difeafes, which neftle and in- creafe in fome of the more vifcid and almofl: flagnant juices, fecreted from the blood ; fuch as the variolous and cutaneous exanthemata, from an infedion or corruption of the aerial mucus and cutaneous liniment ; with the mu- cilages of the urinary and other parts, from ve- nereal infedions j and that of the villous coat of the gula and fliomach, from the bites of Relaxation. 333 inad animals, 5 cc. Here yoU may confult the remarks at the end of led:, II. p. 22. as necef- fary preliminaries. §. 2 All difeafe then is fome vice, either in the ftrudure or adions of the animal veflels, and their contained juices, reciprocally on each other, and fo may be properly didinguhhed into univerfal, affeding the whole habit ; or local, confined more or lefs to particular parts : tho' properly, in the human body, which, like a circle, has, in all parts, a communication or confeht (§. 555.), there is no univerfal difeafe that aifeds the whole fyfiem equally alike, nor any one local difeafe that does not proportion- ably more or lefs affed the whole body. Other- wife difeafes may be ufefully divided, accord- ing to the principal feats or refidences of their nearer and efficient caufes, which are always either a deficiency or an excefs of motion in the folids, from which the motion, quantity, and quality of the circulating fluids are foon after vi- tiated, in fuch proportions as manifeflly call for phyfical aid. §. 3. We have feeOj that all the folids of the human body are either (i.) confijient^ for the configuration, fupport, and defence of the reft, as in the bones, cartilages, cellular fub- ftance, callous or fcaly integuments, &c. which, ferving to give due bounds and refiftances to the reft, are, in thofe refpeds, as important as if they exerted a vital adion. Or (2,) they are motive^ (§. 408.) i. e. able to contrad and elon- gate themfelves alternately by a vital, nervous force, either voluntary or fpontaneous. A de- fed 334 Relakatlofi, fed: in either of thefe motive or refifting pov^ers of the folids, is properly called a laxity or weak- nefs of the fibres, membranes, and veflels.^ The firfi; we call a tonical UDeaknefs^ as it is a diminution of the cohefion, tone or tenfity, in which all the folid threads of an animal arc maintained to ad harmonioufly, and produce health : and the lafl: we call a njital weaknefs, as it comes from a defed: in the motive or mufcu- lar conftridions of the fibreSj membranes, vef- fels, and vifcera. This lad, when habitual, is, for the moft part, a confequence of the firft, which makes the removal of it fo tedious and difficult in chronical difeafes ; but when it is fudden, from haemorrhages, a diabetes, a diar- rhoea, or fome profufe fweat, ’tis more eafily cured. 2 . This is a very necelTary diftindlon In prac- tice, becaufe, in the lafl; cafes, you may ufe freely chalybiates, bark, cold-bathing, alumi- nous and vitriolic waters, or other mere aftrin- gents, with the mofl; fpeedy and fuccefsful events : whereas, in the nervous or vital weak- nefs, if ufed alone, without nervous ftimulants, they would fo far increafe the dead vis tonica over the vis motiva or vitalis, as to deftroy the predominancy, which the laft ought to have in the balance with the former, whenever a fmall increafe of power by the nerves, from the will or outward ftimulus, fhall acceed to put the fame upon a vital contradion. From a negled of this, we daily fee dropfies, jaundice, afth- ma’s, obflrudions of the glands, mefentery fpleen, liver, womb, and other vifcera, induced. Relaxation, 33 1 fbr want of joining proper exercife and Aimu- lants at the fame time, or together with the tiiere aftringents; which, ought, on that ac- count, to be always mixed with aromatics, bit- ters, and nervous or byfterical drugs, for the cure of fuch habitual debilities, as will other- wife foon induce a cachexy and wafting i’n weak children, girls, and idle w'omen ; in hard-drink- ing or unadtive men ; or in weaknefs after fe- vers, haemorrhages, long purging, &c. REMARK. * That we may afcribe due honour to our medi- cal anceftors, who have firft opened the way to this folid, fimple, and unchangeable balls, upon a due knowledge and difcrimination of the nature, caufes, . and effedts of which all juft theory and pradtice in phyfic is derived, give us leave to tranfcribe a few words from our old Harveian friend and contempo- rary, profeftbr Gli;-son, in his anatomical tradts, wrote near a century paft, entitled, De ventriculo^ &c. p. 138 & feq. cap. V. de fihris. Ad fi.br arura ufus, ds? adliones^ /peAant earum robur, irritabilitaSy y cauf^ irritantes. Confiitutio fibr^e eft ‘wel (i .) in- fita^ Cs? organic a ex partiun? continuifate •, vel (z.) in- fluxa ; quay vel vitalis, vel animalis. — ^enfibilitas ad conftitutionem requtritur ; ul apte exiendatur df? contra- hatur : fiexibilitas., ne rigefcat, ne dififiuat. — Inde par- tes foluta ab invicim refiiianty dff vulnera difficilhne re- uniantur, — Conftitutio fibrarum inftuxuy fi deficiat vi- taliSy vis (fi robur illicb in lipothymia languet ; aliter afficiatur in febribus. Si inter cipiatur infiuxus animalisy ut in paralyfi ftupent fibra, turn animales turn mtu- rales : omnes enim fenfu tabius gaudenty 077 inefquey ( ex- ceptis illis qua ad pulfum (fi refpirationem faciunt ) inter dormiendum otio fruuntur. Abiio ergo fibra., duplex eft i contrabtio (fi relaxatio. Fibra fibi permjfa, nuU9 Jiimula 336 '’Relaxation, fihnulo five irritamento lacejfita, quieti fe tradit., ut in fomno. Fihne enervata^ ut in parahft afficiuntur ; item dehilitat^e^ non laxatk, quielem affediant. — PaJJio fihra organtca'^ in diftentione quadam confiitit partium } iia enim patitur.y etiam ah externa caufa. Simplex au- tem fibra fe ipfum fecundum longitiidinem dijlendere ne~ queat. Dijlentio partes dijirahit, cui fihra ipfa reni- titur. Rohiir animale pendet in flilxurn a c'erebro : uti languor vitalis a p'enwrla nut depravato influxu fan- guinis fpirituim. Inter ea jujla prcportionis latitude ft^ modb major ^ niodo minor ; inira quam alterutum abfque notabili la/lone alterum excedat^ &c, — Further on, in this and the next chapter, of the ftrength and irritability of fibres, he advances many other ufeful partitulars, which, with the preceding, doubt- lefs furniflied the materials for Bellini, Baglivi, Hoffman, and our great Boerhaave, to work into more extended and elegant fyftems, equally found and ufeful, both in theory and practice. Whether, or how far, old Gliffon was obliged to his friend Dr. Harvey in thefe hints, which are almoft of equal importance to phyfic with the Circulation it- felf, we muft not prefume to fay. §. 4. The tonical veeahiefs^ dr laxity of the folids (§. 3.), fhows itfslf by various effeds, according to its degree, and as it is extended, either only to fome, or to all parts of the body, or as it hath been of a longer or (horter dura- tion. If the complaint be recent, you have generally a begun cacochylia or indigeftion j whence heart-burn, colics, flatus, coffivenefsi hyfterics, &c. afterwards the cellular fabric too eafily flags or fubfides from fuifaining the lead veflels ; whence the blood becomes loofe, pale, and ftagnant in them j fo as to caufe a livid Relaxation. 337 livid fwelling under the eyes, pale tumid lips, Avelled ancles, &c. And if the relaxing caufes continue a longer time, they afFed: even the Idaft cellular flrata, that conned the medullary fibres of the encephalon and nerves one to another j whence the nerves, for want of due refiftance and fupport, eafily become overfilled by flight impulfive caufes or paffions of the mind, and likewife return too ftrong a report from external objeds again to the mind, in which confifts the nature of tenerity, or weak and tender nerves. This diforder, feen now al- mofl: every day, more efpecially in thofe who naturally, or by habit, have acquired a loofe- nefs of the cellular fabric (Vol. I. p. 28, ult.), and likewife too great a dilatation of the nerves, internally, by repeated and violent efforts of the mind ; fuch as young children, unadive de- licate women, ftudious and fedentary men, &c. increafed by too long indulgence in the warm bed, warm fippings of tea, coffee, &c. or over- flrainings of the veffels and nerves beyond their contradile or recoverable tone, by over-early or excefiive venery, hard-drinking, fevers, &c. 2. From thefe caufes a weakened habit is generally brought on, and fpread by degrees, efpecialiy in thofe whofe firfl fiamina or (hoot- ing threats {§. 16.) were originally formed with too weak a cohefion, from feeble feminal fluids, as is probably now more commonly the fault than ever before in the world : but having, from any or all of thefe caufes, once gained a foot- ing, it fpreads, from the chylificativc, to the fanguineous and ferous fyftems, and, by de- Von. II. Z gfees, 33^ 'Relaxation^ grees, through the nervous, where the dllbr'^ der, lying out of the reach of medicines, rarely admits of more than a temporary palliation, or fuch a cure as will eafily be followed with a relapfe. §. c;. This laxity, although in the whole ha- bit, commonly fhows itfelf more in one (y- flem or organ than in another ; according as fome of them have either naturally, hereditary or abufively acquired a greater difpofition to weaknefs. Hence, (i.) in the firft padages., you have a cacochylia or indigeftion, which, according to the nature of the food or drink, \ is either a four, an oily-rancid, a heavy- flime, or a putrid-alcaline ; whence heart-burns or oppreflions, naufea, rudfus, &c. — ( 2 .) In the fecond paffages, betwixt the heart and en- cephalon, throughout the vafcular fyftem (if the firft paftages fhould have performed their office well) this debility occafions a plethora, the moft fruitful mother of other difeafes, ef- pecially among thofe who feed with Engliffi luxury } whence a propenfity to acute and epi- demic fevers, inflammations, &c. But if the former ( i .) has alfo joined itfelf in company, you have then a cachexia of all the folid, vafcular and cellular fyftems, and a cacochymia of the blood and other juices thence feparated j whence a propenfity to flow fevers, obftrudlions or con- cretions of the gelatinous humours in fuch of the leaft vefTels, where they have the floweft motion (§. 134 ); thence acorruptive dilTolution of the organical or globular humours j fuch as the blood, ferum, lymph, -and, perhaps, in fbme Relaxation. ^29 feme cafes, even of the nervous juice ; hence drophes, feurvies, and confumptive waftings (that are not purulent, from ulcerated vifeera) by fweats, urine, fluxes. See. (3.) The ani- mal or nervous fyftem, produced, by mecha- nical fabricature, from' the encephalon (§.7/3 and 838.) may laftly be more elpecially relaxed Or debilitated, as we faid before (§. 4.), either while the two antecedent fyflems, which fup- ply it, remain tolerably Arm, or are-conjunctlv vitiated j w^hence weaknefs of the mufcnlar powers, as well in the arteries and vifeera, as in the mmfcles properly fo called, low-fpiritid- nefs, chillinefs, tremblings, pufillanimity, and hyflerical diforders, which differ in their de- grees and feats, or extenflons. Thus, morbid folids generate vitiated fluids ; and as a caco- chylia or indigeftion, in the fir ft paffages, can- not well be corredled in the fecond, it there breeds a cachexia and cacochymia, which alfo foon follow from a mere plethora j for if the redundancy, firft collected in the cellular fabric and leaft velTels, by inactivity and over feedinsr, be, by hidden heat, hard-drinking, or violent exercife, urged into the larger trunks, it dilates them beyond their tone ; whence a prefect hs- morrhage or ecchymofis, and a begun phthifis foon enfue ; or more flowly come on a future dropfy, furvy, or aflhma convulfive and phleg- matic, &c. from their inertia on the blood. We have now feen, how difeafes often arife one from another in a chain, by a debility of the folids too flowly moving, or digefling their fluids. Let us norv fpeak a word upon the befl: 2 methods 24-0 Relaxation. methods of relieving them, and then proceed to their oppohtes, which arife from too great denfity of the folids, exerting either a too great fpring, or a too powerful mufcular adlion on the blood, and its juices in the arteries, lungs, and other vifcera, which over compadr the humours, fo that they too eafily acquire the ftate of a folid, by cohering with, what we call, a phlogiftic, or inflammatory tenacity. §. 6. The faid laxity or debility of the folids may be relieved or cured by the ufe of ape- rients, reftringents, and corroborants. ( i . ) Let the firft paffages be freed of their load, not by a ftrong purge, that will difturb the nervous- fyftem, but fo fmall a' dofe of mfuf. Jen. am man. vel fal. Glanb. or a little bolus ex Puh. Rhei G? Cal. that will only clear out the in- teftinal contents. (2.) Let the diet be very fmall in quantity, light, and of good juice, that will eafily digefl; ; as cuftards, bread- pud- dings with eggs, boiled fifh, or white flefhed poultry ; the meal to be only one thing or difh, with light French-bread, and the drink to be as fcanty as poffible, of found red wine and water, p. e. avoiding tea, coffee, or any drink- ing betwixt meals > and let no fat, oil, or butter be eat. (3.) Let the whole body, as foon as the patient arifes, be plunged in cold water, wiped dry, and well rubbed wdth a rough dan- nel, blanket, or a flefli-brufli, with all imagi- nable expedition j and then let riding or walk- ing be pradlifed, ’till they begin to tire, or to fweat. (4.) Let the bed-time be reduced gra- dually to five hours, or lefs, if the patient does not Relaxation, ' 341 Slot flcep in it j and let the air be high or hilly, on a chalk or gravel, if poffible, and the cloth- ing or apparel be gradually extenuated or light- ened during the fummer, and accuftomed to be afterwards worn thin, as diferetion and the weather-clock may diredt, all the enfuing win- ter and after. (5.) Never ufe milk, foups, beer, or other liquors made hot^ in the common courfe of diet ; for this is prteternatural to man, as well as to all other animals, and, by re- laxing the nerves of the ftomach, heart, dia- phragm, and other adjacent vifeera, is pro- ductive of numerous difeafes, in thofe who have them already weak j much lefs fcalding tea, which many drink hot enough to fetch the Ikin off a delicate finger. But if tea be ftrong, and let Hand ’till near cold, ’tis a falutary be- verage for a ftomach that is not four, which cannot be faid of coffee, that is only fit for a relief to debauchees, or an over-meal. (6.) Let reftringents and corroborants be ufed con- jundtly in fmall, and often repeated dofes, in- creafing the quantity gradually, and leaving off in the fame manner, viz. bark chaliabtes, rhub.J pulv. e bol. c. 1 fpec. aromat. | elix. vitr. | infuf. cort. cum fp. acido minerali, vel alcalino vola- tili, pro re nata, &c. Only obferve, never to be over-free in the ufe of chalibiats, bark, or other aftringents alone ; efpecially at firft, and in weak or cold difeafes : becaufe, as they in- creafe the inertia and cohefion of the folids and fluids, over their mufcular vis vitalis ner- vofa, they will thus confirm, rather than cure the difeafe 3 unlefs the latter powers be alfo pro- Z 3 por- Relaxation. portionably excited, by the conjund ufe of nervous ftimulants and exercife. 2. However, there are fome cafes, where they are beil ufed very fparingly, and without flimulants, as when an htemopthoe, a profu- fion of the menfes, night-fweats, &c. come from debility ; or when the organic texture and confluence of the blood and lead vedeis arc only required to be kept up, as in mo{t of the contagious fevers, after the height of inflamma- tory ones, in the putrid alcaline feurvy, in pu- rulent hedtics, &c. But for cedematous debi- lities, which come after fevers, or chronic di- dernpers, with epilepfics or foolifhnefs from the fame caufe, and colliquative difeharges from re- laxed emundtories, weak perfpiratipn, and hy- deric complaints, with rickets in children ; ’tis always bed to join aromatic and bitter dimulants, together with fuch drugs as are redringent. Thus operating conjundtly, by tightening up the vedels, and exciting the vital or mufcular forces of the heart and arteries at the fame time, they gradually caufe and increafp a due degree of plethora, which, by urging the blood mod, where it is lead redded, will over- come uterine or other obdrudtions. On the other hand, a too hady and free ufe of redringents at the fird, without any preparatives or evacuations, and revuldoRS, will often fadly increafe the hae- mopthoe, mendrual or other cxcefdve fluxes, which they are defigned to fupprefs. §. 7. From §. 5. we may underdand, how intermittents arife from cold ropy vif- cidities, colleded in the drd and fecond paf- Rigidity. 343 fages debilitated ; and why they have often a ih'ange anomalous appearance, when, by neg- led: or ill-treatment, the febrile col lu vies has extended into the nervous fyftem. How me- dicines, which have a ftrong abfterhve bitter- nefs, with a powerful reftringency, diflodge, attenuate, and expel the faid matter, either in- fenfibly by perfpiration, or vifibly by the urine j provided it lies within the fanguineous jyftem, as you may know by a lateritious urine, declar- ing for a fafe ufe of the bark ; otherwife, if it lies in the lymphatic or nervous fyftem, you will not cure, but lock it up by the bark, which adls chiefly, by contracting and invigo- rating the blood-veflels, into which the aguifti matter muft be firft returned, by a few fits and ,concufiions of the fever, helped with a vomit, pr a purge or two of rhab. and cah before you attack it with the bark. Hence the reafon, why faline draughts, camph. and other attenuants, often effect, what bark will not, in fome ftpb- born agues, &c. §. 8. The other fource of difeafes, oppofite to laxity (§. 5. «lt.), lies in too great a denfity or compaction of the folid fibres, membranes, veffels, and humours j fo that thofe, which are confiftent (§. 3.), become rigid or unpliable to the vital forces of the heart and nerves, which they ought eafily to yield to ; and from thence the mufcular or moving fibres, and the leaft veffels, clofing up their organic fabric too foon, degenerate into mere tendinous, ligamentary, or often bony threads. This Rigidity or den- fity does not generally call for our aid, before a Z 4 certain 3 4 'I- Rigidity. certain age, as does the former, in mankind at ieaft. However, it may come on too haftily, or prevail too much for the crafis of the fluids, either in the whole habit, or in certain organs only ; by a continuance or repeated alternations of exceffive heat and cold, joined to a parental difpolition in the primitive ftamina, or firft component threads (Phyiiol. §. i6.) ; to which add abufes from allringents, fpirituous liquors, much labour, in an hot fun, or by great^ fires, and repeated diary or topical inflammations, with refpedt to certain organs ; for any part of the body, that has been more fubjed to inflam- mation, or to labour than the refl, becomes thereby more denfe or rigid. In confequence of thefe, and the like caufes, young folks of- ten fhoot up, gain their acme, and expire too foon } as in the late extraordinary Cantabrigian virile infant. Or again, the thinnefl: parts of the fluids, and more watry glue of the folids, being thus too much expended by the more violent ofcillations and expulfive forces of the arterial and cellular fyftems, the former gain fuch an impervious lentor or tenacity of their parts, as we call phlogijiic j becaufe, by cohering more flrongly together, and to the veflels, they thus generate a greater heat from the circulating tri- ture or motion, and are thence apt to hefitate in their way, without extending fo far as the leafl: duds and veffels, which, for health, they ought to pervade : from whence we have a dry, hot, and feurfy fkin ; a coftivenefs, with high-coloured and ftrong-fmelling urine, very fait, and but little in quantity ; a deep or labo- rious Rigidity. 345 rious breathing, with an hard and fmall pulfe; from all which, the perfon is liable to frequent, painful, and inflammatory fevers or ftubborn inflammatory diforders, in fome parts or other, induced even from flight caufes. Such a denfe difpofition of the vefTe's in the vifcera, no lefs than in the miifcles, renders them liable to be cramped (Vol. I. p. 43.), either by nervous confent, or from thofe paffions of the mind, which caufe a more powerful vital eonflridtion in them j after which they ought naturally to relax, only this over-denfe, tonical, or automa- tical, and fpringy force, will keep them for a long time fhut up. Hence, from frights, vex- ations, or pains, will arife a convulfive jaun- dice in the liver ; hiccups or pains in the ftomach, or fupprefTed menfes in the womb ; an afthma in the lungs ; a fupprefTed perfpira- tion and fevers by the fkin, or hyflerical and watry urines by the kidneys ; and fometimes, when the inteflines are lax or open, and the other emundlories cramped, a flux enfues from the former analogous to the hyflerical diabetes, in both which is loft a great part of the fined: nervous lymph, that fhould fupply the ence- . Here every thing will be ufeful to a cure, forbid in the oppofite cafes (§. 5.) ; the warm-bath, warm liquors, oils, mucilages, honeys, foaps, creams, whey, oat or barley gruels, nourifliing or retentive clyflers, a warm and moifl: air, much reft, deep, &c. A good emollient and relaxing drink is an almond eraul- lion in barley water, well charged wdth honey and nitre 3 and a diet almoft entirely of 6 milk phalon §•9 3 4^ Rigidity. milk or whey^ creams, chocolates, fagoe, fa^ lop, &c. and in all the,organical cramps of the vifeera abovementioned, as well as in univerfal and febrile flridlures, bleeding with papave- rines, and often a blifter to the next part, will have their good eftedts. §. lo. This faid inertia, or rigidity of the folids (§. 8.), gradually advancing from our infancy, brings on us, at lafi;, all the fymp- toms and appearances of old age, and termi- nates itfelf by mere vital debility, which we call a natural death ; becaufe the powers of the heart and encephalon are now no longer able to furmount the inertia of the folids, by this time loaded with too great a quantity of earth, deprived of the more thin and fluxile parts of their glue, and changed from their motive or organical fabric, (whether muf- eular or vafcular) into that of folid or over- refifting threads, in fome parts often as tough as ligaments, or hard as bones. Thus the ar- terial fyftem too much refifts the heart itfelf, more callous and infeniible to the ftimulus of the blood ; the lungs make a greater reiiftance to the incumbent air ; and the craticle of the thorax, over-rigid in the cartilages and liga- ments, which allow it motion by the ribs, very hardly yields to the now debilitated or more inert diaphragm, and other refpirative mufcles : hence the more laborious breathings and frequent afthma’s of old people, joined with f^legmatic and catarrhous difeharges from the lungs, and the whole via alimentalis, chiefly bred from the crudities or indigeftions of the chyle, blood, and lymph, in the now weakened or Rigidity. 347 or inert vafcular fyftem, joined with an in- creafed denhty or impervioufnefs of the cuta- neous and renal emuinftories ; whereby the latter, loiing their mufcular power that con^ duces to empty the tubuli, become frequently charged with fabulous concretions or cryftal- lizing granulations of fait and earth, which lay the bafis of tormenting calculi, either in the kidneys, ureters, or bladder. The fame rigid inertia of the folids may alfo enfue, fo as to be retrievable, in younger pcrfons, by me- dicine, from an exceffive ufe of fea-falt, which draws out the jelly, both from the blood, lymph, and fibres, fo as to render the former immotive, and the latter atrophic, or unfit for nutrition ; and fo do alfo fpirituous liquors abufed, but without leaving the folids, like the firfi:, in any tolerable condition of recovering their due organic fabricature and vital motions, by a proper ufe of antifcorbutics. Hence the neceffity of leffeningthe quantity, and of light- ening the quality of the nourifhnents, taken by old people, who ought, if they are defirous or willing to keep health, to join them with daily walking and exercife, according to their ability : becaufe an inertive or rigid debility in the chylificative organs, which are now loaded with unadive phlegm and mucus, inftead of thin falival juices, and have a lefs quantity of a weaker bile, caufes grofs aliments (that require good teeth, at this time wifely rejeded by na- ture, that they may be no invitement) to make a corrupt chyle in the firfi: or alimentary paf- fages, which cannot be correded without light ' wines 34 ^ Rigidity. wines and exercife, when they are once arrived within the fanguineous or fecond paffages, now labouring with a proportionable debility. For in the aged, the adlions of the heart, breath- ings, arid pulfe are fmaller, flower and weaker, as are all but the pituitary fecretions. Their blood-veflels, indeed, always appear remarka- bly full, from the increafed denfity and fpring of the capillary and mufcular increafing over the contradile force of the trunks ; by which, from flight exciting caufes, the lafl: often urge the blood, or its ferous parts, very fuddenly into the cellular or lymphatic fabric of the encepha- lon, fpine, or nerves j whence fudden deaths, apoplexies, palfies, &c. hardly remediable : but as the blood and juices move flower in them, though with a greater compreflhre, they are lefs attenuated or digefled, lefs able to afford repairing nourifhment and nervous fpirits ; whence the coldnefs, feeblenefs, infenfibility, and fhrinking of old folks, with the whole train of chronical diflempers, to prevent or retard which, daily exercife of body, which keeps the folids moveable, or from ffiffening, and fridions of the fkin, with plufh or blanket, un- der the regimen before direded (§. 9.), will greatly conduce. See Phyfiol. §. 257, &feq. §. II. Thefe flates of the folids (§. 3, 4, and 8.) well confidered, in conjundion with the climate, fex, occupation, and influences from the non-naturals, lay the only certain ba- fls of a found and rational pradice j which, whoever negleds, builds on a vague fluxile foundation, that by deviating from the courfe Rigidity. 34^ of nature, will lead him into a field of unfound or conceited methods, whatever enthufiaflical notions he may entertain of extraordinary affift- ances from God, by prayer. But if the fore- fald phyfiological and pathological confidera- tions be firft duly weighed and underftood (See remark at the end of Led:. VI. alfo §. 16, 23, 24, 136, to 139J 144, and 246, to 260.) they will afford a faithful guide, not only to know the conftitutions or temperaments (§. 169.), by which people are inclined more to one kind of difeafes than another ; but likewife of that deftroyed equilibrium or balance in the vafcular fyflem (§. 144.), which by errors in the non-naturals vitiates the motion, quantity, and quality of the blood itfelf, and its feveral fecerned juices, which are often wrongly ac- cufed as prime caufes in difeafes. For the mo- tion and quality of the fluids will be an- fwerable to the proper conditions of the folids, by which they are formed ; and the particular fecretions and organ ical adions will be con- formable to them both. Hence the quantity and quality of the fluids will be, as their moti- ons ; their motion will be as the quantity and quality, including the prefent flate of the fo- lids (§. 6, and 10.) conjundly; and their vi- tiated texture or morbid qualities will be as the excefs or defed in all the former together. Thus we have the firfl: chain that holds the ,.'whole clue of diflcmpers. A chain that ad- mits of no motion or change in any one of its links, without proportionably fliaking or al- tering the refl. 'See remark to the end of Led. V. 3 5® "Rigidity. to whifc'h add 5 thefe caufes vafloufly exx:ited, by other more remote or external and differ- ently combined, lead us into the numerous kinds of fevers and inflammations, which, a's they occupy above two thirds of the fcale of all difeafcs, ought, by phyficians more efpecially., to be well known and fliudied. §. 12. From what has been faid then, it appears, that the general affedtions of the blood, by which it may offend and produce difeafes, are reducible j (i.j to quantity^ re- dundant or deficient; (2.) to motion, exceflavd or defedtive ; (3.) or to confijience^ including its organical and albuminous texture and colli- quation (§. 162, and p. 144.) ; alfo its febrile vifeidity, either that commonly called a vifeid, flow or cold lentor^ from its caufing flow, nervous, intermitting and hyftcrical fevers j (under which w^e include thofe which Dr, Hoffman and others call mefenterical) namely, fuch a cohefion of the ferous and abuminous parts, in the leaft veffels, for want of a duener-* vous and arterial ftrength, as is fimilar to that in the whites of eggs, which by a moderate heat or concuflion by a wilk, gain a watery fluidity : or elfe what is oppofite to the former, a fizey phlogifton or phlogiflic tenacity^ i. e. inflammatory, from the former matter over condenfed, by too great arterial preffure and motion, by which the ferous and lymphatic globules run together, into what is commonly called a buff or pleuretic cruft, as foon as the blood is let out of a vein ; as we obferved more at large in Vol. I. p, 147. (4.) to acrimony ; whether Plethora. 351- whether chilly, as the alcaline, purulent, con- tagious, and gangrenous, or mixed with a cor- roding virulency, as the cancerous, venereal, arthritic and bilious, or thofe from a fuppreffed urine, or perfpiration, &c. Only obferve, that' thefe affeftions of the blood and lymph, here propofed as the more general and nearer caufes of many diftempers, may be likewife intro- duced as effe(Ss confequent, from fome other antecedent or particular difeafes, excited by caufes out of the prefent queftion ; as the air, aliments, wounds, bruifes, burns, &c. §.13. Let us now proceed to treat each of thefe morbid heads (§. 12.) with a laudable brevity. And firft, too great a redundancy of good blood, oppreffiveto the arterial and nervous fyftem, is called ^plethora ; which generally em- ploys its force, fo amply produdive of difeafes, fooner upon the encephalon or lungs, or the portal fyftem of the hypochondriacal vifcera, than upon other parts, as they make a lefs re- ftftance in their vafcular and cellular fabricature, to the impelled fluids. The frequency and fruitfulnefs of this morbid fpring, in our indo- lent and voracious Britons and Hibernians, will excufe me for entering more minutely into its caufes, figns, effeds, and cure, than fome other good profeftbrs have done before. (See remark to §. 14. Pj^yfiol. where [ad vafa) is by miftake tranfpofed for [ad vires). Obferve . then, we are to conftder an over fullnefs, either (i.) as it h (ad vires) oppreftlve to the pow- ers of the heart and encephalon, by lying dor^ mant in the lefs refifting cellular and capillary fyftems 3 35 ^ Plethora, fyftems ; or (2.) as it is (advafa) excited ihtncz into the largeft trunks and branches, which bearing a fmall ratio to the former, are thus eafily over-ftrained or broken. §. 14. A plethora, the figns of which in- clude both the productive caufes, and the cofi- fequent efFeCts, varies according to its quantity or degree, its extent or feat, and the time it has continued. A chylous plethora foon breeds one that is fanguine, as that does one which is ferous or lymphatic ; and that by degrees un- ravels all orders of the web-like or cellular llrata, furrounding the nerves and the leaft veffels, with the whole compages of the vifcera. But the generating and prodiiSfhe caujls are reducible to two heads; including ^ i.) thofe which make more chyle and blood than are neceffary for the fex, habit, or occupation : fuch are a ftrong ftomach, bowels, and liver, joined with coftivenefs ; foods and drinks highly nourifhing, taken too copioufly or too often in the day ; an effeminacy in the habit, make, or proportions of the body in man ; or thofe which are natural to a woman : to which add a fanguine temperament, and a fhort fta- ture. 12.) Thofe which diminifli the circular motion, triture, and expulfion of the blood and juices once formed : fuch as an effeminate weaknefs of the nervous, v^fcular, and cellular fyftems (§. 3.}; a rigid or fenile inertia (§. 10, ult.) ; a deficiency of nervous juices, either in quantity or quality; a reclufe, unacbive, or fe- dentary life, given much to reading or dudy ; an adiaphorous or careiefs difpofition of mind, with Plethordo 3 53 with too much indulgence of fleep 5 or laftly, any accuftomary difcharges too fuddenly flopp’d, diminiflaed or negledted. Thefe lafl may be fubdivided into (,i.) 7 iatural difcharges j from the haemorrhoidal veflels, womb, inteflines, kidneys, Ikin, fpitting, or coughing, &c. or (2.) artificial ‘y iuch as blood-letting, cupping, fetoift, ifliies, purgatives, clyflers, faliirating, fnuffing, chewing, or fmoakingj orlaflly, (3.) fuch as are accidental } viz. from wounds, hse- inorrhageSj ulcers, amputations, &c. §. 15. The preceding caufes may indeed ac- cumulate too great a quantity of good juices in the cellular fyflem and leafl veflels, fo as to produce a fuffocated or latent plethora, that may gradually Vitiate the whole habit by a cachexia and cocochymia ; but if this dormant fullnefs be fuddenly excited^ or driven from the fmaller veflels and flagnant cells into the larger trunks, which have a much lefs ratio of capa- city than the capillaries, it will be then an ex- cited plethora ; which may be fuddenly fatal, by exerting its violence on fome of the impor- tant vifeera before mentioned (§. 13.), if not timely relieved by the lancet, with other eva- cuations and revulfions. Such a fulnefsj with- out artificial evacuations, can only be removed by exercife, gradually increafed, with a fub- tradion from the diet, as thofe well know who deal in fine horfes j having learned by experi- ence the fatal effeds of removing them fud- denly from long reft to violent or fwift labour, which 'f not prefently fatal, feldom goes over VoL. IL A a with- ■ 354 Plethora. without leaving flaggars, bad wind, or a con- fuinptive pining from injured bowels. §. 1 6. Thefe exciting caufes (§. 15.) feem reducible to the following heads ; which in- clude all powers that fuddenly augment the motion or quantity of the blood, from the cel- lular fabric and fmaller veffels, into the larger trunks of the venal and arterial fyftems : fuch as (i.) a too fudden and intenfe heat or cold, weight, or levity of the incumbent atmofphere ; (2.) all acrimonious or ftimulating fubftances, which fuddenly or powerfully excite themufcular conftri6lions of the heart and arteries ; taken either as aliments^ changeable in the firll: and fecond paffages, into the albuminous juices of the body itfelf j or being in a fmall degree above thofe changing powers, and called medi- ernes, excite falutary commotions, which throw them off with the containing humours, by the emunftories ; or laftly, being difobe- dient by their quantity or quality, both to the faid digeftive, and to the excretive powers, remain within the habit, which they fooner or later deftroy, under the denomination of poi- fons 5 the particular claffes of all which may be taken in, either by the common alimentary ways, or abforbed through the fkin, or lungs : (3.) fudden or unaccuftomed exceffes in ve- nery, exercife of body, cares or watchings, anger, joy, envy, &c. augmenting the ner- vous and mufcular forces of the heart and ar- teries, to a febrile height, that foon vitiates the whole mafs, fo as to be not unrarely fatal. And here we may obferve, that fuch nervous fevers Plethora, fevers have different fymptoms in the vifceraj according to the nature of the paffions they arife from. Thofe from exceffive joy, kill often as fuddenly as the plague, by over di- lating all the external and internal pores, and a hidden diffipation of the fineft nervous lymph that ought to fupply the encephalon j as in the remarkable inftance of the baronet’s fon, upon coming to his eftate, mentioned by Dr. Nichols, in his late lecture de anima medica, p. i6. The like we remember, from a hid- den or unexpected preferment, in a man of weak irritable nerves, to a hewardfhip, under the late prime minifter Sir R. W. &c. Thofe from grief, convulfively affeCt the nervous and mufcLilar fabric of the ftomach, porta, and li- ver j whence anguifh, with hiccups, and a fe- ver that is complicated, or in part iCteritious and colliquative j as was the fatal cafe of the late colonel Stewart, at the lofs of a bribed or foreftalled preferment, whom Dr. Shaw vi- fited, &c. (4.) excefs of fpirituous and fer- mented liquors, efpecially fuch as are replete with a great quantity of incorporated air (§. 159.), which is often confined in bottles or clofe veffels, as in champaigne, new wines, ale, cyder, &c. but this by great heat of bo- dy and weather expands itfelf into an elaftic hate, not only in the ftomach and firft palfes, but alfo in the blood itfelf, fo as fuddenly to ■affeCt the nervous fyftem, and fometimes in a fatal manner, as in the late eminent Mr. Che- felden. ( 5.) And laftly from pain or irritation of any kind ading on the encephalon, or A a 2 nerves,' 356 Plethora. nerves, or heart, and arteries, from caufes ex- ternal or internal, in fome one part, or through- out the whole habit, originally or by conlent of parts (Phyfiol. §. 555. )> §. 17. The morbid effects of a plethora, which has arrived to any confiderable degree, in a ftate either dormant (§. 14.) or excited (§. 16.), are various and almoft innumerable, according to the circumftances, (§. 14.), habit, complication, Infomuch, that different lengths of this chain will lead us to its fource, as a primitive internal caufe, either principal or accelTory, producing the majority of difeafes, both acute and chronic. Let us then firft endeavour to reckon up the effedts of a dormant fulnefs, as near as we can, in the order they ftand con- neded, or are produdive one of another : fuch are, an impediment of the circulations, fecre- tions, and excretions throughout the whole ha- bit j too great a diftenfion and unravelling of the cellular fabric, Icaft veffels and nerves, wherever they are the moft lax, and return the leaft adion upon the fluids ; thence a weaknefs in the contradile, automatic, fpring or tone of the folids, and of their mufcular, nervous force likewife. From thence the juices by de- grees contrad a cold, aguifla or albuminous vif- cidity ; the craffamentum is neither fufficiently denfe nor abundant, whence a chilly leuco- phlegmatic habit, and by degrees a cold feurvy, that may end in a fatal wafting, or a dropfy. From the faid caufes enfue a ftupidity of the mental, and a lazinefs of all the bodily faculties, with a perpetual inclination to doling and deep. The Plethora. 357 The fkin appears pale or livid, and bloated or oedematus ; an half-moon-like diftenfion of the veins and cellular fabric appears under the eyes, with a pallid turgefcence of the lips j the pulfe is full, weak, flow, foft, and eaflly fluctu- ating j the urine, too much for the quantity of drink, and either clear (at times) like water, or elfe milky, with a white or reddifh fediment, and a fliining fldii on the top j the eyes fwelled, watery, and red without heat, impa- tient of the leaft cold wind, efpecially upon firfl: arifing in a morning ; the blood too poor, loofe, v4„or ferous, not half cralfamentum, as it ought to be in quantity, and breaking with a preflure much below its healthy ftandard of cohefion the ferum too faline, brackifh or fcorbutic, and the blood either too pale, from an offending acidity, or of a violaceous and dark purple^ from any putrid or alcaline caufe. At length may follow cold or white fwellings in the joints, and lymphatic glans, of the mofl; ftubborn or fcro- phular difpofltion; with nervous atrophies, and flow fevers of all kinds, whether fcorbutic, mefen- terical, hyfterical, leucoplegmatic, intermitting, nervous, &c. To which add many chronic afleifions, nervous waftings, dropfies, green- flckpefs, fluqr albus, diabetes, night-fweats, &c, REMARK. * Which Ihould be about eight drams, to break an hemifpherical bafe, or furface of the cruor • 4 d fri diameter, after Handing 12 hours ■ in hot air, or 24 in cold ; whereas in fevers not colliquative, at or before the height it bears up- wards, to 70 drachms ; as you naay both ufefully A a 3 and CO Plethora. and conveniently experiment, by carrying in your pocket an ivory tube, of the faid bore, 9 inches long, and holding a range of cylindrical dram- weights of lead ; by which, having an outward fcale, you may alfo meafure the fpecihc weight of the ferum and urine, by fufpending with a hair to keep it upright in the fluid. §. 18. The preceding fedtion has given us a view of the confequences, which enfuing from a dormant negledfed plethora, may in time ex- cite moft chronical diforders, with many that are in part inflammatory, only inclining to the more flow or nervous kind. Let us now fee the effedis of an excited, febrile plethora (§. i44-)> which from fome fHmulus of the nervous or arterious fyftems, foon urges the blood and finer juices from the cellular and capillary fyftems into the larger fanguineous trunks, through which they make a quicker tranfit to the heart, not only naturally, but more now, as the greater diftenfion of the trunks comprefl'es or ftiuts up the capillaries, which ought to re- tard the blood’s regrefs to the heart, and dif- ferently in different organs, to form the various fecretions in due quantity or quality (Phyf §. 174.) j by which means mere fulnefs of good juices, kept for too long a time in too rapid a motion, will foon caufe fuch a phlogiitic len- tor as lays the bafts of all true fevers, pleuriftes, &c. as we defcribed it in a remark to Phyliol. §. 16 1. Hence a plethora, dormant or ex- cited, fanguine or cacochymical, appears next to a vitiated ftate of the folids, from whence it chiefly Plethora. chiefly arifes, to be plainly the moft fruitful pa- rent of all other difeafes. §. 19. The confequent fympfomSy figns or effedls of a dormant plethora, excited by any hidden commotion of the nervous or arterial fyftems j are (i.) fpeedy vvearinefs, a fhort- breathing, and a fenfible throbbing of the ar- teries throughout the body, even from flight exercifes of body, paflions of the minds, or other motive caufes (§. 16.). (2.) A turgef- cency of the veins and fldn, with flufhings of the countenance. (3.) A pulfe that is fome- what loft, but large or full, and very labour- ing. (4.) Erroneous flrayings of the red or yellow parts of the blood, into the fmaller white vefiels and continuous dudts, which ought to reiifl: and confine them within the fanguiner- ous fyftem. (5.) Anguifh or oppreflion in the vifcera that furround the heart j and periodical pains, chiefly about the head, back, fides, or joints, either rheumatic or hyfterical, (6.) Mor- bid, colliquative, and weakening difcharges, from flight fpaftic commotions of the mind, exercifes of the body, .or fmall excefles in the non-naturals ; a weak, watery fuffufion of the eyes, night-fweats, or a diabetes, which appear at times, form fpaftic commotions of the ner- vous fyftem. (7.) If the ftrength and refiftance of the cellular fabric, and the pellucid vafcular fyftem s which attend it throughout the body, confine the excited plethora within the large fanguine arteries and veins j the exciting caufes ftill continuing, will bring on acute continual fe- yers of all kinds j or if the caufes urge more A a 4 upon 360 Plethora. upon any particular part, weaker than others, true inflammations enfue, either with or with- out a confiderable fever. (8.) Or if the faid cellular and pellucidly vafcular fabrics yield too cafily to the nervous and arterious powers, now urging the blood with too great impetus from the exciting caufes (§. 16.) j thence follow aneurifmatic, or varicofe tumors of the larger veflels, or cedematous fwellings of the leafl pellucid ones and cellular fabric, more efpeci- ally about the encephalon and nerves, un- der a fenile rigidity of the folids, or cold vifei- dity of the fluids ; whence lethargic, apo- plectic, paralytic, convulfive, and chronical, ner- vous diforders of various kinds. §. 20. The treatment or cure of a plethora ought to vary according as the general or par- ticular caufes (§. 5, 14, and 16.) and their effects (§. 19.}, joined with the circumftances of the patient, and the time, extent or degree of the difeafe itfelf, may point out to the pru- dent and flow formed judgment of the phyli- cian, who is confulted. The generating caufes (§. 5, and 14.), call for correction by their contraries gradually introduced (§ 6.), and as gradually abated, after the cure is confirmed • in which lies one of the mofl: important branches of fkill in the art of healing : but the exciting caufes (§, 16.), to prevent fudden and fatal effects, require to be quelled immediately, by blood-letting, cupping, lenient-purging 5 and revulfions from the important parts more im- mediately affected, by blifters, iffues, clyfters, &c. Let the fleep and diet be gradually leffened, 4 Plethora. ' 361 efpecially in fummer, and the exercifes of bo- dy proportionably increafed (§. 6.) 5 only ob- ferve here, that fuch as cannot confine their appetite to a fmall quantity, Ihould at leaft abate in the quality, i. e. to ufe aliments lefs nourhhing, as are all thofe preferved by fait, vinegar, {pices, &c. the wines dry, Florence,, old-hoc or rhenilh, reduced by degrees to a moderate quantity, and qualified with water, either drank feparately or in commixture. §. 21. Here it may be not improper tofpeak a word of phlebotomy, which being itfelf an inflantaneous and temporary cure for every fan- guine or excited plethora ; and a necefifary means to palliate the numerous fymptoms (§. 19.) that enfue from it, may be juftly efteemed one of the moft extenfive and potent reins with which phyfic is provided for the pre- vention, government, and cure of thofe acute, febrile difeafes, which are not only the moil head-flrong and fatal to mankind, but alfo double the number of the reft upon the whole lift ; and from whence moft of the others, which kill more flowly, or in cold blood, alfo derive their origin. Obferve then, that as the lancet is generally produdive of the moft im- mediate and powerful relief in urgent cafes that lie under the diredion of a prudent phyfician ; on the contrary, a repeated ufe of it, without occafion, either as a preventative remedy, or in cafes feemingly urgent, where yet it is impro- per, we daily obferve to be produdive of the greateft mifchiefs ; although fometimes thefe iaft are both neceftary and unavoidable evils, to prevent 362 Plethora. prevent others that are yet greater j as, e. g. when a febrile lentor has fettled on the lungs, and to avoid certain death by the head-ftrong and pe- ripneumonic fever, many of the fmall veffels contraft and clofe up in the lungs by numerous bleedings, and leave afterwards an habitual afthma from callofity ; or when foolilhnefs fol- lows after a fever, or a phrenzy from the fame caufes, in the encephalon j or a returning pa- raxyfmatical jaundice and dropfy from the like in the liver. §. 22. The only rule then to be relied on, for direding this difcharge to be repeated with falutary efteds in all doubtful cafes, is, the ftandard of the blood’s cohelion ; to be known by experimenting in the manner we before mentioned, after §. 17 : for whenever it is buff, or refufes to break by the preffure of 8, JO, or 12 drachms or degrees, you may be fure phlebotomy, in moderate quantities, is pro- portionably a laudable remedy. 2. Though there are fome cafes where the colliquative power of matter, returned from a vomica of the lungs, or other vifcus, wi.l over- ballance the coagulating force of the hectic, fo as to afford a lax and florid blood, when fliil a repeated ufe of the lancet is neceffary to reduce the vital forces of the heart and arterial fyfcem (by which matter is formed) to fo low an ebb, as may allow the broken or ulcerated vafcules to clofe up, and harden through want of in- fluent juices, in the fame manner as a profufe haemorrhage may fave a perfon fatally wounded, by inducing a weaknefs of the Ireart and arte- teries, Plethora. 363 rles, which excited, would foon be deftrudlive. Hence the ufe of blood-letting in fmall quan- tities, and at proper intervals, for the cure of pulmonary confumptions, to prevent mifcar- riages, to palliate cancerous fwellings, &c. which the vulgar too often condemn as bad pradice. 3. On the other hand, in any cachedical, or ca,cochymical plethora, which being long negleded, has induced a cold albuminous len- tor, and a watery, acrid, or diffolved date of the blood, unable to fupport the preffure of 8 drams or degrees ; blood-letting will have no good tendency, even though local pains from, the faid lentor, or oedematous inflammations of the eyes and other parts, from an erroneous flraying of the red cruor, or yellow ferum of the blood, may feem to fome to be indications for it. But ferous depletions, with blifters and fcarifications into the cellular fubftance of the arms and legs, in people not old j with the other alterants and corroborants before direded f§. 6.), alcalies, bitters, and aromatics, gra- dually introduced, will operate a lafting cure. 4. Hence, when the menilrual paflages have remained blocked up many months, whether by a rigcfcence, lentor, or an organicai fparm, .the taking cold, or a paralytic laxity or the or- gans } every bleeding will increale the cacho- chymical plethora and its confequences, al- though it feems to give a prefent relief: for to bring the uterine difcharges in fuch a cafe to be regular in quantity and conflftence, requires firfl: an improvement of the blood itfelf, by the 'coLirfe of §, 6. afterwards an excitement of the p’ediora, now fanguine by medicines, properly deob- ^64 Plethora. deobilrucnt and uterine, [Ext. Helleb, | Flor» mart. | Cinnab. Ant. j Pil. Gum. | Tind. valer. &c.] with fuch as are in this cafe derivative of a greater flow into the lower fyftem of veflels (vol. I. p. 133, ult.), viz. warm bathing of the feet, and applications of warm, cephalic plafters, hyfteric clyflers, and exercife of body, carried up to an incipient fweat, at the time when they are mofl; likely to break forth, &c. §. 23. As phlebotomy always increafes the circulation through the parts which are neareft the vein opened, for fome confiderable time after the operation ; therefore bleeding in or near the parts affeded, is always derivative of a greater flux to them ; as on the contrary, it is always revulflve when performed in parts that are the mofl remote : confequently, to abate an excited univerfal plethora, it is indifferent in which part, whether arm or leg, the vein be opened j but for the removal of obftrudions or cloggings of the veflds, by any cold vifcid len- tor, fettling on fome organical part, (as in a periodic cephalalgia from that caufe, often called an ague in the head,) bleeding in the ju- gular will there conduce to remove the load, by more increafing for a time the ftrength and adion of the vafcular fyftem, and fo will bleed- ing in the foot with refped to obftrudions of the menfes. 2. But fince bleeding in the arm or neck requires the ufe of a ligature, from thfence the blood-veflels of the parts intercepted are more entirely emptied, by the hidden filling of which, upon taking off the ligature, a revul- flcn Plethora, 365 fion is Inftantly made thither from the vital or- gans; whence thofe who are weak, faint, upon untying the ligature, fo foon as the lofs of fpring or arterial tenfion reaches the heart and ence- phalon : but as bleeding in the foot requires no ligature, only theufeof warm water; therefore in all inflammatory cafes of the head, breaft, or abdomen, it makes the befl: revulfion both of fulnefs and phlogiftic tenacity ; as it at the fame time makes a ftrong derivation to the ute- rine or haemorrhoidal veflels ; and ail this with- out fubjedling the patient to faint, unlefs the quantity be exceflive, becaufe the depletion is every moment transferred equally throughout the whole, without falling at once fuddenly on the heart or encephalon, as it does by the ufe of a ligature. (See the remark to §. iqar vol. I.). 3. But the cafe is otherwife in cupping with fcarification, which evacuating more of the febrile lentor, without weakening the arterial or nervous fyflems, always makes a revulfion from the internal parts, or a derivation to the fkin outwards ; and is therefore the mofl; ufeful when nearefl: to the veflels communicating v>^ith the parts affedted. What we have here faid of revulfion and derivation, may be alfo applied to bliflers, pains, or any local ftimulus ; and in fome meafure to purging, vomiting, or fweat- ing, by external heat. But for inflammatory and plethoric aifedtions of the kidneys, bladder, and genital parts, bleeding from the arm will undoubtedly have a better effedl ; as alfo in fome cafes not inflammatory, where the tone of 3 66 Atrophy. of thofe vafcular parts is to be recovered in a diabetes, whites, feminal gleetings, &c. §. 24. The other vice of quantity in the blood and juices, produdlive of difeafes, is that of deficiency or manition (§. 12.), which in- deed may be often itfelf a diftant confequence of a dormant fulnefs, too long negleded, as we before obferved (§. 17. ult.). This fpring of difeafes, being mofl commonly known by the name of a nervous atrophy^ imports a mere .collapfion of the cellular, vafcular, and mufcu- lar fyflems, with univerfal weaknefs, from too great vvaffings, or too fmall recruits, of chyle, fat, blood, lymph, and albuminous nouriib- ment throughout the whole habit, without any ulceration or organical deftrudlion of the folid veffels and vifcera. This, like a plethora, varies according to the time of its duration, and extent within the habit, by paffing from one organical fyftem to the ocher j becaufe a great deficiency of the chyle will caufe one of the blood ; this, one of the fat, lymph, albuminous nourhbment, and nervous fpirits : fo that though the lafl link of this chain, over worn, or waffed by irritation, either upon the nervous or arterial fylfem, feems, by way of eminence, to have given title to this difeafe, or rather complication of diftempers j yet we fee it is as often produced by defedts in fome of the ante- cedent links, which neceffarily fuflain the latter. §. 25. The caufes therefore of inanition and atrophy, feem reducible to the following heads; (i.) an over weaknefs or indigeftion of the chylilidcative organs, both in the tone of their eladicity, Atrophy, 367 elafticlty, and their xhufcular forces (§. 3.), whether habitual, from the age, fex, or birth ; or acquired, by excelfes in eating or drinking, violent purges, vomits, or clyfters too long ufed, &c. whence a cocochylia, either oily- rancid, four, putrid, or vifcid, according to the corruptive nature or inclination of what is taken into the ftomach, upon which it makes too long a ftay. (2.) Aliments in themfelves too oily, heavy, poor, acrid, or tough and vifcid, for the age and exercife ; overcharged with fait or vinegar, which deftroy their gelatinous or nutritious parts ; or elfe, which is rarely the cafe in England, by ftarving the meals, taking them in too fmall a quantity, or at too long in- tervals. (3.) An over tendernefs and irritabi- lity of the nervous fyftem, too eafily difpofing to cramps and waftings, or profluvia of the emundtories, hyfterical hectics, &c. (4.) The heart and arteries too much irritated, either from a want or an excoriation of their defending mucus ; or from their nervous and mufcular forces, excited by paffions, pains, &c. or by a fcorbutic acrimony of the influent blood. (5.) A weaknefs of the arterial and nervous powers by immoderate venery, drinking, watch- ing, labour, grief, defire, or love, &c. (6.) Ex- ceffive hemorrhages, or other difcharges, whe- ther natural, artificial, or accidental (§. 14. ult.). Laftly, (7.) from a dormant fulnefs, inducing by time and negledt all the confequences before mentioned (§,17.). §. 26. The cure or treatment of a nervous wafting may in a great meafure be derived from §. 6 , ^68 Atrophy. 6, having at the fame time a regard to fuch of the produdlive caufes (§. 25.), as are more diredtly concerned in the cafe confulted. The atrophy that is chylous, from indigeftion and a vifcid obftrudlion of the mefentery, which, as Dr. RadclifF judicioufly obferved (V. Cowp. in Tab. 34. died. Bidlowi anat.) kills a great many of our infants and elderly people ; is beft attacked with fmall boles, ex Rhab. & Calam at pro- per intervals, followed with Tindt. Guaiac. voL and the nervous deobllruents {§. 22. ult.', with much riding in a rough-hac upon the ftones, &c. Obferve to corredd the cacochylia, if oily or putrid, by fmall dofes of the cort. joined with mineral acids ; or if the firfd paffages be four or mucous, give the fame with fal. diuret. or give the Tindd. cort. P. vol. | T.guaic. vol. & valer. vol. entering on them, and leaving them off (paulatimo by dofes gradually increafed and diminhhed. That wading which comes from irritating caufes (§. 25. n*^ 3. to 6.) mud be re- lieved by abdradling the dimulus, and appealing the irritation by nervous, papaverine, nitrous, and mucilaginous medicines, in bol. & hand. I dor. mart. [ troch. e. fuccin, & e nitro. | pulv. e. trag. ] pil. e. dyr. | pulv. e. bol. c. cum op. I baud, falin. cum fperm. cet. | fyr. me- con. ades milk, &c. That from excedive difeharges (§. 14. ult.) mud be redrained by the fame, and by §. 6. For fcorbutic, hedli- cal atrophies, in fea-faring gentlemen, golden- pippins and nonparels, fcooped in good plenty, are highly ufeful, andTindt. cort. cum elix. vit. d. ^ but avoid milk with them, or even whey, if -t' fours Atrophia : fours Upon the flomach 3 for then brod* vipe^ far. cum pullo will be preferable. 2. Thofe fcrophulous and cancerous erofions of the womb, bladder, mei'entery, pancreas, liver, ftomach, fauces, mouth, &c. that often follow from, or are joined with a cacochymical negledled fulnefs, in women pafl child-bearing, or from excelTes in cachedlical men, &c. are fel- dom more than to be palliated as above, by keeping the circulation as low as poffible, and ufing a very light or thin diet. When the nu.- tritious powers are reduced to their lowed: ebb, the white of a frefli egg, mixed with a gill of fweet whey, when alfes milk cannot be had, with or without fweetening cum fyr. de me- con. may be given to advantage every three or four hours ; to which add, for change, the jellies of fruits, hart’s-horn, new creams diluted with tea, almoft cold, broths of lobders, or ra- ther cray-fidi, boiled with rice, or with crud: of bread that has been well baked, &c. joined with the exercife of carriage to a proper di- dance, fird in an hand-chair, then in an horfe- chair and coach, &c. and afcending to a dronger diet and exercife by degrees, (§. 6. per tot.). 3. Infome four domachs, the acid incentive fo penetrates into the membranes and vifcera, (as we fee the bile penetrates the coats of the gall- bladder and colon) that, by operating imme- diately on the vegetable or acefcent part of the aliment, the whole, even though it may be in a .great meafure animal fubdance, foon becomes a corroding-acid, or indigedible mafs ; for’tis, by this incentive acefcent power, a little fcrap of the VoL. II. B b dried 57© Atrophia. the dried ftomach of a calf, macerated in water, makes rennet, for curdling milk, &c. Forfuch ftomachs, therefore, mere broths of cray-fifli, vipers, chicklings, jellies, cuftards, &c. will be preferable, v/ithout any acefcent fubflance. §. 27. We have now feen, that the fluids, offending by excefs or defedt in quantity ( §. 12.), will always either abate or increafe their mo- tion above the healthy flandard, that is or ought to be conftitutional ; whence a vitiated quality or texture may, by degrees, foon fpread itfelf throughout the whole habit, in all the numberlefs diforders, imputable either to a plethora (§. 13.), or a wafting of the fluids (§. 24,), or elfe to their motion, confiftence, or a morbid acrimony j which two lafl always offend, in proportion to the excefs or defedt, and duration of the former. The healthy motion then of the fluids, which alone keeps them from running into the cohe- lions of a folid (Phyfiol, §. i. and remark to §. 1 6 1.), may, like their quantity, offend by excefs or defedt ; and that, either univerfally, throughout the whole habit, or locally, in fome particular organ or vifeus, to be underflood in a proper latitude (§. 2.). But as this equable and healthy motion of the fluids is relative to the age, fex, climate, feafon, &c. (§. 137 and 138, Phyfiol.), fo their morbid excefs or de- fedl, as to the faid motion, may be judged of, under thefe* circum fiances, either by reipiration or the pulfe ; the former of which, with Hip- pocra’'es, we efleem a more certain and inllruc- tive hgn in acute difeafes, than even the pulfe j only Fevers. 371 only It requires more attention, and a longer courle o’-' cblerv’auon, to bring it to the fame ufes in practice, (i.) dt deficiency of motion in the fluidb, beinp-generally introduced, with allits chronical effects, in a manner infenfibly., from a dormant or negledted plethora, joined either with an effemiuace relaxation or a fenile rigidity, it may be known and treated, from what we have before advanced under thofe general fources (§. 1 to 27.). Of Fevers. §.28. But (2.) a too quick motion of the hu- mours thro’ the arterial and nervous fvitems, while the body is unexercifed, caufing an uneafinefs, with an over increafe of the heat and actions of the organs, throughout the habit, is called a fever ; but when it is fenfibly extended no far- ther than a certain part of the body, it is called an infiammation. Every fever then is the effedl of fome Simulating caufe, operating on the ar- terial and nervous fySems, and thereby ur- ging the heart to larger or more frequent con- tradlions ; as every inflammation is the confe- quence of like caufes, locally confined, and ir- ritating the mufcular fySakic contractions of a particular artery and its branches j v/hich is again more intenfe, as the tonical or elaftic force of the faid artery is raifed to a greater height, by a fuller diftention of it with juices, (Vide Phvf. §. 44. remark). Hence the reafon, why a itimulus will put a nervous or plethoric perfon into a fever; that in others, ot a low, fluggifh or poor habit, will only add Itrength, or even cure a chronical diftemper. And, therefore, the B b 2 caufes. 372 - Fevers. caufes, which create a plethora, and more ef- pecially thofe which excite it (§.6.), are par- ticularly produ6live of fevers and inflamma- tions, which, being always, more or lefs, join- ed one with another, and making the moft common, either caufes produdive or fympto- mical attendants of other difeafes ; in a due knowledge and treatment whereof, our medi- cal {kill is capitally employed : we fhall, there- fore, for own fatisfadion, as well as that of our younger brethren of the faculty, attempt to delineate a concife, but juft and plain, pyre- tologia, conformable to the beft pbyfiological and pradical lights we now have, §. 29, The moft ufeful and primary diftinc- tion of fevers feems to us, therefore, dedudory, (I.) from the feats of reiidence of their principal or ftimulating caufes. that too much increafe the heat and motion of the blood, or induce moft of their inflammatory and difcri mi native fymp- toms •, or, (II.) from the nature andoperations of the faid material caufes, to be fubdued or re- moved by art and nature, feparately or conjundly employed. By the firft, we divide fevers into ( I ) fuch as are contagious orcuticular, in which the febrile caufe enters through, or ads princi- pally in the fabric of the outer or inner Jki'i^ with which the air and aliments, with all they contain, have a free coimmunication or contadj for, in thefe, an epidemical or contagious mat- ter, of various kind and origin, takes up i sre- fidence in the mucous, febaceous, and ferous pores, follicles, andcryptje, not only outward y, but more eminently in the airy and alimentary paftages, where they ilowly fpread and corrupt the Fevers. the juices, with the villous epithelium and adja- cent cellular fabric, much after the manner of a venereal gonorrhea j whence ophthalmias, co- ryzas, coughs, peripneumony internal j fore- throats, oedematous, gangrenous or convulfive, or both gangrenous and convuUive*; inflamma- tions of the ftomach, inceffant vomiting of its contents and diarrhoeas, bilious, ferous, fan- guine, &c. But if the faid matter be difpofed to go further than the alimentary mucus, with the chyle, blood, and lymph, it commonly ex- cites a fever malignant, of a particular kind, by attacking the encephalon, or eruptive, in the ex- ternal fkin. The cure in fuch cafes, is by an eva- cuation of the offending matter from the parts principally injured by maflicatory, vomit, pur- gative, clyfler, warm bathing, &c. and a mo- derate elevation of the vital powers, by acefcent drinks, with nervous diaphoretics, blifters, &c. obferving to keep up the found texture of the fo- lids and fluids againft the colliquative force, by a due ufe of min. acid, in lindt. with bark, camph. nit. fal. armon. &c. See Phyfiol. remark to §. 164. In the firft llage of thefe fevers, often a moderate blood-letting, in thofe who are plethoric, will fo relieve the oppreffed heart and encephalon, as to produce, like a cordial, a more eafy and happy iffue or expulfion of the offending matter towards the fkin 5 provided the blood’s cohefion be above the healthy flandard (§• ^ 70 - REMARK. * When the infedtious faliva of a mad animal has multiplied and neftled to a certain quantity, B b 3 within o> 7-^ Fevers. within the villous covering of the phauces, gula, and fcomach, either by pafTing thither immediately, by kifling and flav'-ering with a mad cat, dog, horfe, &c. or more rem.otely and flowly, by paffing thi- ther through the blood, infefted by a wound or bite. It being the nature of this rabious polfon not to operate moi tally, by a dread of water, until it has excited a gangrenous inflammation in the faid villous lining ; (fomewhat fimilar to the action of variolous infection, that exerts its force on the true fldn) whence, by nervous confent, it alfo, for the moft part, caufes a fever, delirium, and convul- flons, which are not fo foon fatal, as thofe from a gouty or ftrong peftilent matter, adling on the fame parts. §. 30. The feconei clafs of fevers (§. 29, I.) arlfe from a fiimulating caufe, or febrile mat- ter feated in the blood and lymph, with a ten- dency to difiblution or digeftion by the fever it- felf, aided with antipyretic medicines, fo as to pafs off, either infenfibly or apparently, by the fkin or kidneys, which are the natural emunc- tories to the fanguineous fyllem, and vicarioufly fubftitutive one for the other j or elfe lefs na- turally by a diarrhoea, either critically or artifi- cially excited. To this head we refer all flow, anomalous, and feemingly nervous fevers, ari- fing from a cold, indigefted, albuminous vif- cidity, extended through the chylificatw'e and fanguificative fyftems, (from the caufes of §. 4 and 5.), and often extending even into the en- cephalon and nervous fyftem, when it excites fevers, either truely fpaltic and nervous, or elfe thofe which we call local and irregular inter- mittents, with fuch as Dr. Hoffman and his Fevers, 375 predecelTors have properly called mefenterlcal*. Add to thefe, fuch as we term remittents and intermittents, and which, after a fmall conti- nuance of the fever, and a bole or two ex rhab. and cal. always yield to the bark, with or without an emetic and nervines. But befides this more weakly-ftimulating, albuminous, or intermitting vifcidity abovefaid, which, by often fettling in the abdominal vifcera, lungSj or en- cephalon, caufes a variety of hippifh, hyfte- rical, nervous and polymorphous fevers 5 there is a ftubborn phlogiftic or inflammatory matter arifing from oppofite caufes (§. 8 and 16, and Phyfiol. p. 147.), by Vv'hich the blood tends to too tough or coriaceous a confiflence, joined with pains, either in the fide, limbs, or other parts ; as we know by that appearance of the blood, from whence we call it buff or pleuritic. And this, with an hard pulfe and a clear urine, we efteem the charadleriftic of an inflammatory fever. But obferve, this lentor, by a conti- nuance of the fever beyond its height, with bliflers, diluents, attenuants, faponaceous dif- folvents, &c. will not only melt and run off in a thick matter critically by fweating, purg- ing, or urine ; but fometimes the healthy glu- tinous coheflon, of the red and other parts of the blood will, by a continuance or increafe of the fame caufes, acquire a putrid dr gangrenous thinnefs ; whence a new fever, of a different kind and treatment, will arife, commonly called colliquative; becaufe here the permanent texture, connexion, or glue of the red and yel- low globules of the blood being diffolved, as B b 4 when. 376 Fevers. when you m‘x it with an alcaly, it runs to v/afte through the fkin, kidneys, or inteftines, &c. (V. Phyfiol, vol. I. p. I ;3, and feq.) In which cafes, mineral acids, with the bark, make a divine remedy, that would do great mifchief, before the digeftion and height of the faid in- flammatory fevers have diifolved the ientor. REMARK. * (Therap. de morbis dignofcendis, c. 3. §. 6.), which I have fomecimes known, as a local re- mittent in the mefentery, produdtive of a flow ir- regular fever, v/ith a v/afting ferous diarrhoea, that has exhaufled the patient, in fix or eight weeks, to the loweft degree of an atrophic, with an exfolia- tion or renewal of the whole internal villous epi- thelium from the alimentary tube, and even blad- der, in an ingenious apothecary, whofe tedious cure pafled from me to that of Sir Ed. Hulfe ; for when the whole mefenterical colluvies had ran off, almoft at the cxpence of the lafl; drops of nature’s forces, that gentleman’s recovery was no lefs fudden than iurprizing to every body. Here the fever is irregu- larly remitting, very little inflammatory, and the blood in good condition ; the pulfe and breathing in no wife intimidating ; the urine fometimes cru^e, pale or nervous, and, at times, depofiting a fediment, with a good deal of ropy vifcid matter and furfu- ratious or cuticular exfoliations from the villous lin- ing of the bladder ; the tongue fometimes furred white, or but Iktle inclined to yellow; the eyes, as in an cedematous opthalmia, from weaknefs; the fleep fhort, and often interrupted, with a load or eppreflion in the lower-belly, although you have a purging, &c. §.31. The third and lafl: clafs of fevers, ne- ceffarily diflinguifhable by the feat of their caufe (§• 29. Fevers. 3 77 (§. 29, L), includes thofe that arife from fome inward ftimulus on the encephalon, or any ner- vous part thence proceeding ; and this either alone or conjoined with fome other primary or coniiderable vice febrific, either in the hr (I paifages, that convey the chyle (§. 29-), or the lecond, that convey the blood and its ferous juices (§. 3c.). And thefe are the fevers, which, in the ftridleft fenfe, merit the title of netvou^^ or low; becaufe of the low fpirited- nefs, fighing, fofc and weak pulfe, inconfider- able heat, and propenfity either to a copious watry urine, (not improperly called nervous or hyfterical) or fweats of the fame kind, which furpriiingly exhauft and debilitate the patient, with refpedt to his whole nervous fydem ; be- caufe the fined: gelatinous lymph, that ihould afford immediate fupplies to the encephalon and nerves, is exhaufled by thofe drains, or thrown out from the blood ; in which we are confirmed, by the unacrid or fweet, and clammy nature of both thofe difcharges ; or it may be by infenfible exhalation, excefiive )n too warm a cli- mate. Here, then, the immediate caufe appears to be a too defedfive or imperfedl repletion of the encephalon and its produced nerves, with that fine, organic, or globular lymph, which, from the quicknefs of its operation, betwixt the ac- tive foul and body, rather than from any fimi- litude of fubftance, we call animal or nervous fpirits. This deficiency may arife from all the caufes (§. 2^.) that exhaufi; them too faft, or elfemake them too llowly (§.ib.) ; particularly a weaknefs, both tonical and mufcular (§. through- 37 S Fevers. throughout the arterious fyftem, and relaxations (§. 4.) of the cellular webs, that are not only interpofed throughout the organifm of the en- cephalon, but alfo betwixt every fingle tube and fafciculus that compofe the nerves, \^hich, thus wanting a due lateral refiflance, too eafily are over-diftended by urgent paffions of the mind, &c. In fome weak frudious men and women, a fudden abatement of the air’s pref- fure on the body, upon an empty ftomach, when the weather is hot and moift, will fo far weaken the arterial fpring on the encephalon, as to have the effeds of a profufe bleeding, and excite a proportionable degree of this fever, which foon yields to a little frelh air in a coach, orange juice, and rhenifli or other light wines, with or without the cortex and nervous medi- cines; premifing, before the laft, a little bole ex pulv. rhab. or an ounce of the infuf. fen. &c. to wipe off the redundant pituita, that com- monly overcharges the firfl paffages in fuch ha- bits. To this head belongs the febricula, of which Sir Richard Manningham has given a whole treatife; but fuch as confidersit, I think, as a part of hyfterical diforders, more than any original or primitive fever. ’Tis true, that an in- flammatory or pleuritic lentor of the blood and lymph may, in the advance of adiapneuftic, catarrhal, and other fevers fettle in the encepha- lon, and fo intercept its fecretion to the nerves, as to excite many of the fymptoms proper to ner- vous fevers ; but then the ftupor and contrariety of conneded caufes (§. 8.) will plainly enough point out, to the judicious, the wide difference there Fevers. 379 there Is, both in the nature and treatment of thofe malignant, from the prefent nervous fe- vers ; in which laft all evacuations, heaters, and fudorific medicines are highly injurious, except blifters, that are of common benefit to both, although in a different way. §. 32. As the mofl; common material caufe of thefe nervous fevers, is a cold albuminous vifcidity of the lymphatic juices, affedting the cellular and nervous fyfliems, like as the crude vifcidity in the fanguineous fyftem (§.30.), is the common caufe of intermittents and remit- tents j therefore many of the bitter, fcetid, moderately aromatic, and nervous medicines, are equally falutiferous in both : only the adn.i- rable cortex you mufl never ufe here, any more than in the former, until the pale nervous urine begins to form a lateritious feparation or hypo- fiafis. For unlefs the febrile matter of thefe, as well as of many intermittents, be frft re- turned from the ferous, cellular, and nervous, into the fanguineous fyflem, to which laft the force of the cortex is principally confined j it will exclude or bind up the matter within its weak bounds, fo as to confirm or increaie rhe diflemperj whereas, after the faid matter has been fomewhat attenuated, [by blifters, hauft. falin. julap. camph. tindt. vaier. vol, &c.] it will return into the blood, after a few paraxyfms or emetics have fhook the habit, and naay then be happily and infenifibly exhaled by the cortex j which, for want of this precaution, often fails of its admirable effedls in nervine fevers, by locking up the courfe betwixt the ferous and fangui- Fevers. fangulneous fyftems, much as it often proves a ufeiefs load or clog to the firft or chyliferous paffages leading to the blood, when filled with vifciditics ; until you have removed the laft by a bole ex rhab. cum calam. or an emetic with baud, falin. camph. &c. Let, then, the lancet, with flrong purgatives and fudorifics, be cau- tioully avoided in nervous fevers 3 but make free with bliders vin. ipec. julap, cam. tindl. valer. vol. caflor. &c. with plenty of fack or white wine whey. If the bed cannot be avoided, let the covering be as flight as poffible, the air cool or temperate, the vifiters few or none, the curtains and furniture violet, and a light barely glim- mering or perceptable, the head cool and raifcd, the chamber often fprinkled with an equal mix- ture of good French vinegar and rofe water, or a napkin dipped therein, and hung on the back of a chair near the bed-fidej or if fome paflions or didurbances of mind dill continues to inter- cept a recruit of fpirits, by refrelhing lleep, foft chromatic mufic, whofe rithmus does not ex- ceed or move falter than a healthy refpiration, viz about 20 or 30 changes in a minute, play’d piano from organ, harp, violin, &c. in an ad- jacent room, fo as to be jurt audible by the pa- tient, will often lead him into an agreeable dumber to good purpofe. If the fever holds long, or is partly mefenterical, with an heavi- nefs about the abdomen, ’tis of a groll'er mat- ter, that calls for lenient cathartics ex rhab. tin and a denfity of the habit i§. 8.). Emollient and diluent clyflers, here afford a good way of giving camphor, that offends theflomach, but thus may be repeatedly ufeful. But bliflers, mere or lefs, with plenty of diluents, are in thefe generally of fervice, and in mofl of them diredlly neceifiary (§. 44. n°. 4.). flaufl. ex. Tindl. cort. p. f. j. with acet. camph. (made as the julep, e camph. only ^ij. to a pint, is little enough, as this acid referains it more, and rare- ly imbibes above half a fcruple of it) ij parts alum Fevers, 40 1 alutiij gr. ij. or iij. nitre, v. or vj. with fyr. mecon. q. f. makes one of the mod potent an- tifeptics, which is at the fame time highly alexipharmic or diaphoretic, that pharmacy can produce. By this, with or Vvdthcut the acid, artfully dofed and timed, you may either hll the crude ferous pock with laudable matter, or elfe turn the laudable pock into a dark gangre- nous condition, by often giving it when there is no occafion : but in putrid, malignant, and epidemical fevers, that tend to no eruption, you can rarely do any mifchlef by it. — After thefe come the mealies, fmall-pox, and pefti- lence ; the two former of which we fhall next conlider. §.43. The mealies and fmall-pox, though modern diftempers, are very near relations, and invade much alike, in the manner of other ori- ginals (§. 33.. n°. 3.), from a febrile matter; only here the head and back are more efpecially ahedled, by a local fulnefs, in the apparatus or inflammatory flage of them. The eruption of both is aifo preceded with feme licknefs, or a vomiting and oppreflion of the flomach ; only the rifmg fpots of the mealies break out fooner, after three or four days, fo as to be upon the dry-turn, by the time that the pock is well out, or maturating, viz. on the feventh or eighth day. As the morbillous matter is not fan- guine, or inclined to fuppuration, but of a fe- rous or lymphatic nature, leaving the habit about the feventh or eighth day in a dry feurf ; fo it more efpecially afledls the lymphatic and cellular fyflems, principally in the head and VoL. II. D d lungs, 402 Fevers, lungs, after the manner of a corryfa or cold. Hence the little or no abatement of the fymptoms given by the morbillous eruption j and the troublefome peripneumony, that gene- rally calls for the lancet and laxatives, on the eighth or ninth day, when they are on the dry turn. But the flea-bite eruptions of the fmall- pox are more rifing, and give confiderable eafe or abatement to the fymptoms ; except that in the copious or confluent pock, there is a trouble- fome purging in infants, or a fpitting in adults, which are hardly ever feen in the diflindl fort : and from the ceafing of thofe difeharges, with a return of matter to the blood, about the end of the third or maturative flage, i. e. from the 12 th to the 15th day, a new fecondary or fymptomatical fever, requires to be treated, as the morbillous peripneumony, by the lancet and laxatives, as the infuf. fen. vel. rhab. cum manna, &c. 2. Now as both the meafles and the fmall- pox often owe their malignancy to an involun- tary infedlion in the autumn, by a complication, with an aguUh or a phlogifbic lentor (§. 33. n°. 3.), condenfed by the fummer feafon, ante- ceding in one over denfe (§. 8 ) or full (§. 13.) ; therefore we advife every body to encourage the inoculation (of this otherwife modern ravager of mankind) by planting a more favourable ver- nal fort, after due depletion by the lancet, and a bol. ex rhab. cum cal. vel infuf. fen. &c. in full habits j and an attenuation, by the bark and asthiops, in denfe, phlogiftic, and in ner- vous chacochymical habits. Thus the inocu- lated Fevers* 40 j lated fmall-pox, will have the adv^antage of near loo to onei over that which comes probably at the worft feafon, in a bad or unprepared ha- bit, and from the moft malignant fpecies. 3. The meafles generally pafs over, among the poorer folks at lead, without much affift- ance from the apothecary, or any advice from a phyhcian ; for indeed they feldom w’ant any, unlcfs to forward them by cordials, or when the oppreffion on the lungs, at their exdcation, calls for the lancet, blifters, or laxatives. As the purging in infants, or the fpitting in adults, that attend the confluent fmall-pox eruption, abate the violence of the diflemper ; although they are fymptomatical difcharges, they muft be only moderated under an excefs, or even be excited if they flow not enough : fo the firft may be reftrained within bounds, by a mixture with tefbacea & tinft. rhei vinof. & tindt. cinnam. given in frequent and little potions, or excited by a larger proportion of the tindt. vel fyr. rhei. vel rofar. folut ; and the fpitting may be promoted by oily emulflons, with fal. c. c. tindt. myr. lac. amm. vel julep, e camph. flor. benz. & fyr. half. &c. But the treatment of excefs in this difcharge, you may befl: judge of from theiex- traordinary cafe which Dr. Wilmott gives in his father Mead’s book de Variolis, in which the patient w'as reduced to a fkeleton by a faliva- tion, equal to one from mercury, that held above a fortnight. Here, from the eighth to the 1 2th day, inflead of a maturative fuppu- ration, a violent head-ach, dyfpnaa, and lan- guor of the artery attended j till about the end D d 2 of 404 Fevers, of the time a ftrangulative quinfy invaded, and foon after was relieved by the faid fpitting,. en- tering on the 1 2th day. He fuffered nature to continue her drain, under a fluid nourifliment and diluent liquors, and recovered his patient as one in a tabes j viz. by repeating the lancet, one in a week or two, to the third time, in a quantity not exceeding fix ounces, with rhab. q. f. to purge at intervals (without which the body gains a hafty crude fulnefs), hauft. falin. cum fp. cct. and afTes milk for the hedic ; 'and finally corroborants, elix. vit. aq. fpad. r. rhab. &c. 4. As the crude or cryflialUne pock requires forwarding, by rich fack-whey, with fal c. c. confedb. card, and blifters on the extremities, by the fifth or fixth day from their eruption j fo the bloody, whether from the kidneys, in- teflines, or mouth, require to be reftrained by min. acids, with tind. cort. laxatives, and fome- times the lancet, with bliflers.# As for lenitive purges, in the clofe of thefe and mofl; other fevers, they ferve in part to exterminate any relicks, but more efpecially to prevent a too hidden and crude fulnefs, by which thofe whom thefe fevers have greatly impoveriflied, would otherwife fufier, in their head and nerves, by a fooliflanefs or ftupidity, or in their whole habit, by a fcurvy or a dropfy. 5. Dr. Huxam of Plymouth, wbofe good judgment and extenfive pradice have enabled him to oblige the wot id with fome ufeful writings on thefe heads, judicioufly obkrves in the latefl of them i that the quantity and con- dition Fevers. > 40 ditlon of the blood, either poor or denfe, with an aguifh or inflammatory lentor, or a fcorbutic acrimony, have a conflderable fliare, in con- jundtion with the epidemic feafon and fltuation, towards determining and changing the pock to be either diftindt or confluent, crude, gangre- nous, or bloody. Thefe, joined with an inter- mittent, are to be treated with the bark. Thofe that come with a pannick, and run to the ten- derer internal epithelium of the lungs and ali- mentary tube, are to be timely follicited to the Ikin by bliflers and foments. The black, gan- grenous pock calls for the bark and mineral acids, after having firfl: removed the difpnsea or the conftipation of the bowels, as above diredted, when they attend. The fecondary or purulent fever, attacking the head by deli- rium, &c. is a good warrant for the lancet and lenient purgatives ; as that which comes before the eruption is for clyfters and papave- rines. Alfo in many flow, feemingly nervous fevers, where nature is unable to throw out a critical difcharge by the emundlories, we have experienced that lenitive purges will make a fort of artificial crifis, to the great comfort of the lingering patient : but it is on another ac- count (§. 40. n°. 2.) they are often fo ufefui in the beginning of epidemical, contagious, and bilious fevers, viz. by feafonably excluding a good part of the fomes, while nature can well fuftain them. Sudorifics are never to be ufed in the beginning of any but peftilent fevers, and to promote thofe fweats which are critical and relieving, after the height of epidemicj malig- D d 3 nant. 406 Fevers. nant, or inflammatory ones ; and even then the mildeft, ex acet. camph. 6c aq. f. alex cum fyr. de mecon. with thin diluents and warm covering, are the heft. §. 44. Eruptive fevers being all (§. 42, 43.) naturally ot the colliquative kind, (unlefs when conjoined with a lentor, either aguifh or in- flammatory ; the firfl; of which they diflblve foon, and the other later, but with more vio- lent fymptoms) they wdll in general come un- der the fame method of cure j viz. by mode- rate depletions in full (§. 13.) anddenfe (§. 8.) habits, at the firfl; onfet, or inflammatory flage of them, by lancet, emetic, or mild purgative, 6cc. or elfe omitting them in the relaxed (§. 4.) and impoverished (§. 25.), go on with fack- whey, more or lefs rich of the wine ; with fuitable cardiac and diaphoretic medicines, con- fec. card. | pulv. cont. | julep, vel acet. e camph, [ tinct. valer. vol. | aq. alexit. 6cc. in draughts and boles, fo dofed and timed, with diluents, as to keep the circulation above na- ture unexercifed, but below any degree of fweat. 2. But be cautious of your bleedings, or de- pletions, as they are here not curative of the fe- ver, only calculated to abate their firfl or in- flammatory flage ; which may be known from the tenfion or rdiftance of the pulfe, and tena- city of the blood ; and therefore rarely to be pradtifed after the firfl attack, hut under the moft prefling fymptoms, and in deliberate con- fultations, in which fometimes they are ordered with fuccefs, under management of thofe who are Fevers. 407 are the moft fkilful and erpinent j and particu- larly for relieving the encephalon or lungs in the maturative and declining flages of the fmall- pox, mealies/ &c. 3. So opiates are, in general, equally to be fufpedled here, as they increafe the laxity of the arterial and nervous fydems, with the al- ready peccant colliquation of the fluids, where- by fuch an erroneous ftraying of the cruor en- fues, into the pellucid and fine cellular fyftem of the encephalon and lungs, as foon lays the patient into a fleep, from which he will never awake. However, if the tone of the velTels, and texture of the fluids be duly guarded by mineral acids, with tlndt. cin. cort. p. &c. Pa- paverines may be then advantagioully given in the evening to abate the painful irritations, coughs, watchings, and uneafinefs, which in- creafe in thefe, and in all continuants, -about the clofe of the day j and arife to a more con- fiderable degree, in tender and nervous habits. 4. Blifiers rightly managed, and frequently cupping, are of great ufe in all thefe fevers, not only by -dividing or digefting the lentor, with which they are often complicated ; but more efpecially as the former are a lading fpur to the diaphorefis, and naturally derive the malignity towards its proper emundory, or even power- fully remove it, from the entrenchments it may have made, in the lead; veflfels and cellular fa- bric, which organize the encephalon, lungs, and abdominal vifcera ; and therefore a timely ufe, and a moderate repetition of them will rarely fail of their falutary effeds. So alfo will D d 4 the 40 8 Fevers. the ftimulative epithems, plafters, &c. In whlcli camphor muft make a principal ingredient. 5. But as nature, or the fever itfelf, is here the principal curative agent, fhe muft not be too haftilyfpurred by thele (n°. 4. fup.), nor by cordials, beyond her falutary and moderate pace ; up to which fhe mufl; be raiftd by them, v/ith light good nourifliment, in the malignant or ferous kind of the frnall-pox, that lag be- hind a laudable fuppuration, for want ol a due ftrength in the folids, or a confiftency in the fluids : as on the contrary, ihe mull be reftrained by depletions, papaverines, and the tindl. cort. cum fp. vitr. when the fanguine or phlogiftic fort run together diredly like ecchymofes, in the very onfet of their firfl flage, fo as often to be gangrenous by the fourth or fifth day, and foon after are either produdlive of a colliquative and fatal haemorrhage, through the renal or alimen- tary pafl'ages, that bids defiance to all art ; or if there be a lucky efcape, ’tis commonly with fome gangrenous or incurable ulcer in the lungs, vifeera, or otner part of the body ; all which misfortunes come oftener from unfeafonably negledling the over fulnefs and denlity of the habit (which are the chief heads to be regarded towards inoculation (§. 13. §. 8.— §. 4, and 25.), or by urging them with too keen fpurs, than from any extraordinary force in the epi- demical or infedling matter. 6. For reafons above given (3.) you will ne- ver venture upon opiates in children, or lax ha- bits, before the fmall-pox are maturely out, nor when the lungs are fufibcatingly opprefTed, or ■ Fevers, 409 or the encephalon comatous, or delirious : for only by the ufe of paverines (with difcretion, as above), epithems and good warm covering to the feet, with an emollient clyfter every other day, both the reftlefsnefs, and the oppreffion of thofe important vifcera may be happily re- lieved. To this laft treatment, with opening a vein, will yield the delirium that comes three or four days after the variolous eruption j in which the infuf. fen. may often be ufefully given. Strong children may bleed at firft, by leeches on the temples, or otherwife ; but in the weak and tender, which have often con- vulfive motions, a little before the eruption, it may have the moft fatal effeds, by withdraw- ing the matter, which that commotion denotes to be now advancing on the fkin : and fo too, in robuft or adult youths, the early opening a vein once, twice, or thrice, will often raife the oppreffed circulation, throw out a mild erup- tion, and prevent a delirium, or worfe accidents. Whereas the meafles call ftrongly for cordials, rather than depletives and coolers, in their be- ginning ; and require the lancet at the turn of the diitemper, with lac. ammon. | papaverines, myrrh, oily emullions, &c. to relieve the fuf- focative peripneumony about the ninth or loth day, which often leaves a deftruftive ulcera- tion in the lungs, as well as the fmall-pox. 7. In thefe fevers, volatile alcalies are not miichievous, but by an excefs, in diffolving the gelatinous texture of the fluids, and by the fame power weakening the fpring of the folids ; flnce,Dr. Pringle has now ingenioufly cleared them ^10 Email-Ton, them from any other putrefcent quality, and fiiowed they are antifeptical on dead fubftance. But obferve in living animals, there is a neceffary diftindion betwixt putridnefs and purulency; in promoting which laft, fparingly uf'ed, and with diluents, they have, in general, a peculiar ten- dency, by which they may be of great ufe in the crude fmall-pox and peftilent gangrenous eruptions, that want laudable fuppuration. §. 45. What has been now faid of the fmall- pox (§. 42, 43, and 44.) might fuffice for the experienced and intelligent j but for the fake of thofe who are only entering upon the prac- tice of our healing art, in fo frequent and weighty a diflemper, we fhall defeend to a de- feription more minute and hiftorical. The fmall-pox are then either epidemical^ de- pending upon a particular conftitution of the air, generally feizing, at the fame time, almoft all fuch as have not been affeded with this dif- order before j or [2.) contagious, being com- municated, by the morbific effluvia that arife from the affeded patient, to others within the fphere of their adivity, whofe bodies are fuf- ceptible of their impreffion and influence. They invade in any feafon of the year; but efpecially in fpring and fummer. In autumn they are generally of a milder conftitution, and upon the decline ; but the fooner they appear in the winter or fpring quarter, they are of a more malignant nature. They principally feize children, more than aged perfons, and are of two different forts, viz. the diJiinB, which ffand apart one from the other ; and die con- fuent^ Small-Pox, 41 1 jluent, which run one into the other : the latter of which are attended with greater danger, as having a variety of fymptoms, which are not found in the diftindt fort j and of a more perplexing nature, The courfe of the diforder, in both forts, conhfts of four different periods, viz. the invafion, eruption, maturation, and exficcation ; all which are fooner run over in the diftinit than in the confluent kind. 2. When c\ih^r invades, the patient is im- mediately feized with a fhivering and fhaking, followed by an acute feverifh heat, attended with a white tongue, thirft, lofs of appetite, drowflnefs and heavinefs of the head and eyes j a fharp humour irritates his nofe, on which account he often fneezes, and his eyes itch, and are waterifh. His eye-lids appear fwollen, he vomits frequently, has a dry cough, and diflicult refpiration ; he feels violent pains in his head, back, loins, and at the pit of his flo- mach, if it be prefied with his hand j his pulfe is quick and high, his countenance fluffed and florid, his urine fometimes, as in an healthful (late, but generally crude and turbid, and his blood, at this time extravafated by the lancet, appears pleuritic or fizy. Convuifive fits in children now prognofheate an immediate erup- tion j unlefs they arife from the difficult breed- ing of their teeth. They, who are affedled with the diflindl pox, have a great propenffty to fweat, which is peculiar to this fort j and in the confluent, the eruption is ufually preceded by a loofenefs, which is feldom or never to be ob- ferved in the diflinft. The fymptoms, now men- '412 S'mall-Pox. mentioned, increafe from the firfl Invafion, and continue ’till the eruption ; but with unequal vehemence, in the two different forts : for, in the diftinft, they are of a milder nature, but in the confluent, the fever, ficknefs, refflef- nefs, and vomitings are very violent, and gene- rally remain two or three days after. 3. The eruption^ in the diftindl, commonly happens upon the fourth day, after the firft in- vafion, and feldom later ; but thofe of the flux-kind make their appearance on the third, or very often fooner, but feldom or never on the fourth, unlefs it be when they are retarded by violent pains, or other extravagant fymp- toms that aftedt the patient. ( 1 .) In the d/JUnSi kind finall flea-bite pimples now appear here and there, efpecially in the face, neck, and breaff, and gradually over the whole body, which daily increafe in height and bignefs. At firff they are red, afterwards they become chryffalline, by degrees obfeurely pale, and then more^ yellowifh at the top, ’till the time of their full maturity. By thefe the fkin and fiefh adjacent are inflamed with great pain, and tumifled. The eye-lids now become fo fwollen, that they clofe, and thereby the patient is de- prived of fight, which generally happens on the eighth day ; which is, therefore, to be par- ticularly obferved in this diffindt fort. After- wards, in proportion to the number of puftules, the hands, fingers, and other parts are feized with an inflammation and tumour, which di- minifh on the eleventh day ; for, at this time, the difiindl are at their full maturity. From thence, Small- Pox, 413 thence, they gradually dry up to the fourteenth or fifteenth day, when all, except thofe on the hands, fall off. After the pufiules are gone, fcurffy fcales arife, which commonly leave fome impreflions or pits behind. But (2.) the con- fluent, at the time of their eruption, appear fometimes like an eryfipelas, and fometimes like the meafles. In this fort, the puflules do not arife fo high as in the difliind:, being fmall both in the face and trunk ; but become larger, the nearer they approach to the extremities. In the face, they are conneded with, or run into one another j infomuch, that it appears as covered with a red bladder. After the expi- ration of the eighth day, the fkin, which be- fore was fmooth, gradually becomes rougher, and the puflules turn of a more dufldlh or dark colour, ’till the time of their maturity. After this, they dry and fall off, in refped of time, according to the feverity of the poxj for, where they have been violent, the face is not altogether freed, ’till after the* twenty-third or twenty-fourth day. When the puflules have fallen away, the fcurffy fcales fucceed, which are here of fuch a corrofive nature, as to leave deep pock-holes, and often unfeemly fears, or contradions and feams of the fldn behind them. 4. In both forts, the fever is at the hig heft from the firft invafion to the eruption, whence it gradually declines ’till the maturity, and then totally vaniihes j but, upon the exficcation, a fecondary or new fever begins to appear, par- ticularly in the confluent-kind. The fymp- toms. 414 Small-Poic. tomSj which In the diftind-klnd, affesfled the . patient at the invafion, immediately ceafe upon the eruption ; but, in the confluent, al- though they be more moderate, they continue feveral days after. When the puftules of the confluent fort begin to dry, a falivation arifes in adults, and a loofenefs in children. The former is obferved in fuch, a conflant attendant upon the difeafe j but the latter has not been fo generally obferved. 5. The fymptoms of moft dangerous confe- quence that arile in the courfe of this difeafe, are ( i .), if, on the eighth day, in the diftindt kind, the fwelling and rednefs of the face and hands, as alfo the fweat, which all along pcr- fpired from the patient, ceafe on a fudden : if upon this he becomes delirious and reftlefs ; and if he urines often and little at a time j for thefe prognoflicate immediate death. (2.) If, in the confluent, the falivation ceafes entirely on the eleventh day, without a return, and without a continuance of the fwelling in the face, or any manifefl appearance of a beginning, turgency, or fwelling of the hands. (3.) If the matter, which fhould be difcharged by fa- livation, becomes fo vifcid, that it cannot be evacuated j upon this, there is danger of fuf- focation, from the difhcult refpiration, and un- eafy deglutition that arife j in moft of which cafes, the patient quickly retires to another life, (4.) If either in the confluent or diitindt, the fever he violent through the whole courfe of the difeafe ; if there be a difficulty of refpira- tion, a phrenzy, or coma j if there be purple. Small-Pox. 415 livid, or black fpots, either between or upon the tops of the puftules, and if, upon their eruption, they immediately difappear. (5.) If the matter, contained in the puftules, be of a gangrenous nature, or if a mortification arifes in the parts. (6.) If there be' an haemorrhage of the nofe, an immoderate and fudden flux of the catamenia, an htEmoptofis, bloody urine, a midlurition, or total fuppreffion of urine in young people. Laftly, if the puftles on a fudden come flat, and if a loofenefs arifes in adults. 6. The prognoftic rules, for judgment in this diforder, follow : the difeafe, in itfelf, is not of a very malignant nature ; for if there be no ill management, it generally runs through the different periods (n° 2 and 3.) without any confiderable danger, and commonly terminates in health ; but fometimes unexpectedly in death, or another difeafe. In the diftinCt-kind, the eighth day, and in the confluent, the ele- venth are principally to be regarded j for ac- cording to the nature of the fymptoms that arife on thefe days, fo muft be the determina- tions made in refpeCt of the life or death of the patient. The kind and degree ,of malignity in the difeafe muft again be determined accord- ing to the appearance of the puftles in the face. If upon the invafion, the fymptoms be not very violent, we have reafon to expeCt, that the other different periods will be favourable, and vice verfa. For the moft part, the flower the eruption, the more favourable we find the dif- order. So the fewer, fofter, rounder, more pointed at the top, more diftinCt, larger, whiter, 2 and 4 1 6 Small-PoKi and (in the courfeof maturation) the vellowerj and the more remote the puftles are Yrom the face, the better are the events to be expeded. But the more they are in number, efpecially in the face ; the lefs in magnitude, the (harper and more ichorous their matter, the more they flux or run together, the bluer, browner, and blacker they look, and the fooner their erup- tion, they are fo much the more malignant. The hotter, redder, and more tumid the in- terftices between the puftles are, at the time of maturation, the greater are the hopes j but the paler, browner, and more flaccid they appear, lb much the worfe j for, upon thefe, a quinfey, or a mortal peripneumony ufually invades the patient. This difeafe is lefs dangerous in wo- men (if not pregnant), in children, and in fuch as are ol a foft, phlegmatic and lax dif- pofition of body, than in old, denfe, or rigid people, and fuch as have been accuftomed to hard labour. If the external habit be only af- feded, the event is lefs dangerous j but if the jaws, gula, inteftines, ftomach, or other in- ternal parts be feized by the puftles, the dan- ger is the greater. j. The diforders or bad effedts this difeafe leaves behind, after it has run through its dif- ferent ftages, are thefe that follow ; viz. deep pits, or pock-holes, contradions of the fkin, and unfeemly fears or feams in the lace. Pearls, in the cornea, or a weaknefs or inflammation of the eyes j as alfo dimnefs of light, and olten total blindnefs. Convullive, epileptic, and apopledic fit-S} malignant tumours and apo- ftems, Small-Pox, fthems hi feveral parts of the b6dy ; an afthma, pleurify, and peripneumony or inflammation of the lungs ; a phthifis or confumption, and very often a cachedlic, or ill habit of bodyj by means of which, the patient is rendered un- happy through the whole remaining part of his life. 8. If we enquire after the original of the diforder, we find, that it is but a new difeafe, or of a late date ; for we cannot difcover any defcriptions of it tranfmitted to us by any of the ancients, which may be taken as an unde- niable argument, that it never appeared among them. For it cannot be fuppol'ed, that they, who were fo very diligent in making obferva- tions on other difeafes, fhould not leave us any hifliory of this, which now makes fuch a formidable appearance in the range of diftem- pers. Befides, ’tis evident, that, at this day, ’tis entirely unknown in feveral parts of the world ; and that, in the Weft-Indies, it was never heard of, ’till the Spaniards conveyed it thither fome few years ago ; at which time, the infedtion was of fuch difmal confequence, that (the proper method of managing this di- ftemper not being known) whole nations fell a facrifice to its fury. The firft, who delivered us any. account of this difeafe, were the Ara- bians, whofe obfervations, both as to the hi- ftory, caufe, and method of cure, are fo ac- curate and juft, that our modern authors have made but fmall improvements in any of thofe parts. Of this, you may be convinced by the perufal of Mefue, Razes, and Avicenna ; Vol. il E e whence 41 8 Small-Fox. whence the places ufaally produced from Hip- pocrates, Galen, and Celfus, will appear fo very foreign to the purpofe, as to need no par- ticular refutation. §. 46. Since the general and moft rational treatments of the fmall-pox may be colledled from §. 42. and the following j therefore we fhall now only add to the preceding hiftory (§• 45') ^ word or two upon its inoculation^ and upon the antidotal or preventative cure j which laft is propofed by Dr. Boerhaave, the late eminent profelTor in the univerfity of Lei- den. This truly learned and judicious gentle- man, conhdering the fmall-pox as an acute and continual fever, whofe puftules are only a critical difcharge of the morbific matter, efteemed it no ways neceffary to wait the dif- ferent periods of the difeafe ; but, upon the firfi: invafion, recommends immediately proper evacuations, fuch as venaefedions, vomits, and laxatives, as alfo the cooling regimen, pre- fcribed in other acute difeafes, by which he aims to prevent the eruption of the puftules, and the other confequent ftages. But, with all due deference to the judgment of fo great a man, this method feems mal-pradice, as it expofes the patient to many and prodigious hazards ; firft, becaufe there is a fudden and contrary motion introduced in the fluids, entirely oppofite to the diredions of nature, and the genius of the di- ftemper ; which procedure has generally been obferved to be very detrimental to the human frame, and always difallowed by the mafters of our art. For fince phyficians are the affiftants Small-Fox. 419 of nature, it is their bulinefs to fupport, and not to thwart her in her operations, unlefs we find, that they tend either to the deftrudion or ill habit of the body. Secondly, becaufe, by this method, the patients are fubjedled to repeated afiaults of the fame difeafe. For fince there is here a latent feminium of the pocky matter, in the folids and fluids of the body j and fince ’tis impoflible to think, that there can be a due feparation and difcharge of it by this method ; the patient mufl; unavoidably be liable to the attacks of this difeafe, whenever the particular conftitution of the air, in which the fmall-pox is epidemical, happens to be predominant j or whenever the difpofed patient is within the fphere of adlivity, pofiTelTed by the contagious effluvia that arife from an in- fedted body : for, fuppofing the fame caufes to be adling with the fame force, and under the fame difpofitions of boviy, it neceffarily follows, that the fame morbid effedt mufl: conftantly be produced. Now the learned Dr. Mead’s late treatife on the fubjedt fhows, that perfons are not abfolutely exempted from catching the con- fluent kind of this diftemper, altho’ they have had the diftindl j and that, even after both, a perfon may have a variolous fever, either with a few, or with no eruptions : and confequcntly (by §. 33, n°. 3, before advanced) the perfon, thus treated, will be only fubjedled to a worfe kind of the difiemper, unlefs a fpecifical anti- dote could be found to throw out the matter infcnfibly (like the cortex for intermittents), without caufing cutaneous eruptions. Dr. Ee 2 Lobb 420 Small-Pox. Lobb aflures us, the aethiops minerale will have this elFedt, giving a dram of it, every four hours, to the quantity of an ounce, or up- wards ; and in a lefs proportion, that it either prevents infedtion, or procures the mildeflkind of the diftemper ; which we cannot vouch for, upon our own experience. But we re- commend it, or the cinnabar of antimony, to relieve the patient, finking under the violence of the confluent kind ; namely, when fpitting is flopped, and the fwelling of the face is abated ; and when a new fever arifes in the beginning of the exficcation ; for which a mer- curial ptyalifm was recommended, and pradlifed by the late learned and ingenious Dr. Pitcairne. That this may be of very confiderable fervice, is plain and obvious ; in that, it is the very method purfued by nature j in that a confider- able difcharge is hereby made; and in that, the tumour of the face is again railed and continued for a due time ; the advantages, refulting from which, are eafily difcoverable by the hlflory of the difeafe (§. 45.).— However, this is a method only to be ufed by the iudicious, and thofe who know how to govern both diflem- pcrs and medicines, according to the jufl rules of art ; but is never to be put in pradlice by ig- norant pradlifers, with whom it will be only a fword in a mad man’s hand, carrying along with it immediate death and deflrudtion. The method of purgation, pradlifed and recom- mended by the celebrated Dr. Freind, Dr. Mead, &c. on the fame occafion hands firm on expe- rience, fupported by matter of fadl, than which we cannot have a more fubflantial rcafon. 2. We . Small -Pox. 421 2. We now come in the fecond place to pro- pofe the method of inoculation^ for mitigating the difeafe. In the eaftern countries, and fuch as are very much expofed to the influence of a hot fun, the fmall-pox being generally epi- demical, is alfo very malignant, infomuch that vaft crouds are yearly fwept away by their violence. This has excited all perfons, both learned and ignorant, to prailife a variety of ways, that they might with more fafety and expedition, either curb or prevent their deflruc- tive influence. At laft, either by chance, de- dudlion of reafon, or experiment, they happily fell in with the method of inoculation. The author of this is not tranfmitted down to us ; but there are feveral who lay claim to the praife. That it firfl: proceeded from fome of the populace, who were neither men of for- tune, charadter, nor learning, feems very pro- bable, in that it appeared in the world, witli- out the leafl: recommendation from any of the learned, and met with very confiderable oppo- fltion from the rich. In feveral parts of Greece, the vulgar had it pradlifed upon them j and from time to time it prevailed more and more, ’till, at laft, it was approved of and received in Theifaly, and the adjacent parts. The Turks, at firft, declared very much againft the pradtice; but, at prefent, convinced by the confequences, they readily -admit of the operation, and are as induftrious in giving it the due recommenda- tion it deferves. The Italians alfo, being apprifed of the method, and of the fuccefs confequent E e 3 upon 422 Email-Vox. upon it, conftantly imploy their operators in an epidemical feafon, and thereby prevent a great number of inconveniencies that might other- wife enfue ; and to come nearer home, we now have the happy advantages of inoculation, very well attefted by the whole body of the learned in our faculty, throughout the Britifh domi- nions. The method of the operation, as it is pradifed in ThefTaly, Conflantinople, and Ve- nice, is, as follows : in the beginning of win- ter or fpring, when the fmall-pox happens to be epidemical, a proper fubjedl is chofen, from whom the pocky matter is to be taken, and this is generally a boy of twelve or fourteen, or a youth, who is afFedled either by contagion, or the difpofition of the air, and labours under that pox which is of the diftincft kind Some of the puflules upon his legs and thighs are opened on the twelfth or thirteenth day, at which time the pox are at their full maturity. The pus is prefled out into fome fmall veflel, which has been well cleanfed with warm wa- ter : this is covered and kept warm in the bearer’s bofom, ’till fuch time as ’tis conveyed unto the perfon, upon whom the operation is made. After his body has been duly prepared by the diredtions of a judicious phyflcian, ac- cording to his particular conflitution, and the nature of the difeafe, which is to be tranf- planted (§.43, n°. 2.) ; he retires to his cham- ber, which is ordered to be kept neither too warm nor too cold, and there waits the per- formance of the operation. After all matters have been duly adjufted, the operator pierces crofs- Small-pox. 423 crofs-ways, or obliquely, the mufcular parts, particularly in the arms, legs, or thighs with a lancet or three-edged needle, ’till fuch time as the blood flows, and feparates the flcin from the parts beneath j into thefe wounds the ope- rator drops a little of the pus, which all this time has been kept warm, takes due care to iutermix this morbific matter with the flowing blood, by the affiftance of fome pointed in- ftrument, and immediately covers the wounds with half a nut-fhell full of lint, or fome fuch concave thing, and fixes it thereon, with pro- per bandages, for the fpace of twelve or four- teen hours, in order to prevent the cloaths or any accident from rubbing it from the parts, or from wiping away the pus, before it has entered the velfels, and intermixed with the mafs of blood. It has been obferved, that al- mofl; all, who undergo the operation, have the pox : and that thofe few, who have efcaped them upon inoculation, have laboured under them, when they have been epidemical : but that thofe, who have had them by the tranf- plantation, have never after been affedted with them through the whole courfe of their life. The regimen, preferibed after the operation of ingrafting, is, as follows : the patient is or- dered to be confined to his chamber, and to keep his bed. His diet, through the whole courfe of the diforder, is adjufted according to the nature of the difeafe, the different tempe- rament, the conftitution, and other circum- ftances of the patient. He is diredled to abflain from wine, and all other things that are apt to E e 4 inflamq 424 Small-Vox. inflame the blood, not only during the feveral periods of the difeafe, but alfo for fome time after. In Conftantinople and Venice, they re- ligioufly forbear the ufe cf eggs, fiefh, and broths, for the fpace of twenty-five or thirty days. Some, who have been obftinate in giving fmall regard to thofe directions, by indulging themfelves in unallowable liberties, have there- by been expofed to a variety of dangerous fymp- toms, which have fometimes proved fatal, viz. violent htemorrhages, difficult refpiration, phren- fies, deliriums, peripneumonies, ftranguries, bloody urine, fluxes of the catamenia, diar- rhseas, dyfenteries, and the like 5 all which were the confequences of their irregular con- duct, and no way depending upon the real ge- nius of the difeafe, nor the operation, which always renders them much lefs mifchievous. For thus the propenfity to vomit, the refilel- ne.'s and the pains affeCting the loins, fides, back, and head, were fo trivial, that fmall notice were taken of them; and the whole courfe of the dlforder, raifed by the method of inoculation, has always been obferved of a much ffiorter date, than when it has appeared in a common way. The parts, conftantly afteCted, are the places where the wounds were made, and the morbific pus infliiled, in which arife puflules by maturation, filled with a fanious, but not a pu- rulent matter, as in the common fort; and tome- times apoflhems, which fpeedily tend to luppu- ration. The number of the puflules, eniuing upon this operation, are but very lew, leldom or never exceeding above an hundred in num- Small-Pox. 425 ber, and tbefe always of the diftindl kind. Sometimes they are obferved only upon the places where the inc;fions were made •, fo that the face has generally been left entirely free. After the maturation, they conftantly have been obferved to dry up in a very fhort time, and are alfo attended with this particular advantage, that after their falling off, the fcurfy fcales that enfue are not of that fharp corrofive nature, which is found in the diforder, when raifed in the common manner of infection, from whence the deep pock-holes, contractions of the fkin, unfeemly fears, &c. confequent upon this diftemper take their original : for no one has been found any way pitted, or otherwife disfigured, upon whom the inoculation has been performed. Neither are the patients liable to any of the unhappy diforders that fo fadly affeCt others, after the difeafe has run through all its ftages j fuch as the weaknefs of the eyes, pearls, blindnefs, difeafes of the head, cacheCtic habit, and others already mentioned. Befides all thefe, there is another advantage, viz. that it always is attended with delired and furprizing fuccefs, from the firft introduction of the. me- thod, ’till this time. For there has not been any conftitution of the air, feafon of the year, temperament, age, or fex of the patient, in which the inoculated Imall-pox have been known deftruCtive. Thefe, being really matters of faCt, may be fufficient encouragement to all, efpec\ally for children and the fair fex, to endea- vour to have this method promoted and prac- tifed throughout the kingdom j as alfo to phy- I ficians, 426 Small-Pox. licians, fargeons, and apothecaries to direct their friends and acquaintances to encourage the operation; to the advantage of which, they may be eye-witneffes in our London ' fmall-pox-hofpital. §. 47. Although perfons are rarely affcdled twice or oftener by the fmall-pox or meafles, ’tis very probable, that a feminium of them, or of fuch like contagious fevers, is often conjoined with thofe which we call eryfipelatous ; where pains, with third:, a redlefs-anguifh, and vefi- cations of the fkin, either puflular or gangre- nous, are conftant attendants. In this we mav be confirmed, if the fever is, at the fame time, epidemical, and the blood little cohefive ; which will be an indication for ufing the mild diapho- retic method (§.42. n°. 5.) with julep, camph. haufl. falin. teftac. cumfperm.cet.&c. But if the eryfipelas appears toarifefrom an excited pletho- ra (§. 16.) or an habitual relaxation with a fcor- butic acrimony ; it may, in the firft cafe, be fafely reftrained by the lancet, with laxative or cooling purgatives ; and in both the attacked part may be corroborated by reflridlive-atte- nuants, acet. camph. [ tindl. fly pt. helvet. jalum. rup. cum acet, camph. &c. ] And in the fcor- butic fort, rhubarb purgatives at due intervals, with the cortex as an alterative, joined either with a mineral acid or a volatile alcaly, accord- ing; to the prevailing acrlmonv, will be of con- fiderahle fervice. But never urge, even mere daahoretics, in thefe fevers, up to an exage- r. t ng Iweat ; and be particularly cautious of the lancet, when you find the pulle in them Of Remittents. 427 to be labouring but foft, and with a bilious ap- pearance of the Ikin ( ), Cf Remittents. §.48. The laft capital or confiderable clafs of original fevers we fhall fpeak to, are thofe before diftinguiflied by the title of paraxyfmati- 41.11°. 3.); and thefe either ( i.) remitting, or, (2.) intermitting : in the former of which, we have remarked, that the febrile lentor has an intermediate tenacity, betwixt the tough phlogiftic fize of continual ardents, and the more loofe or albuminous vifcidofintermittentS) by which, thefe fevers are very liable to be- come, either truly inflammatory or aguifh. For thus epidemical continuants will, towards their height, often be attended every day with a chill, or a remarkable abatement of the fever; which denote, that it will be either foon an intermittent, or elfe of a very long continuance, if not aflilled with the cortex. So, on the contrary, an intermittent may, by heating me- dicines, with an abufe of the lancet and pur- gatives, in an exhaufted habit, be turned to a bad remitting or continual fever; in which our judgment by the urine becomes reverfed ; as the turbid hypoflrafis, that denotes concoc- tion and improvement in original continuants, is here only a fign of crudity and ftubborn vio- lence ; but a clear redifli urine, or a little brick- dufl: fediment, proclaims a cure from the bark. A remittent then has a remarkable chill or abatement of the fever periodically, either every or every other day, at diftances equal or unequal; 428 of Intermit tents. unequal ; generally of a flubborn difpofltion, and inclined more towards acquiring the ap- pearances of a bad, nervous (§. 31.) or a ma- lignant (§. 41. n°. 5.) continuant than to form a faiutary crifis. Here I have raifed the patient from a cold dead poflure (with a defpaired-of ftupidity or coma, unafFedted by blifters) in a very wonderful manner, by boles given every four or fix hours ex conferv. flav. aurant.^ hifp. Sj. ext. cort. p. dur. vcl mol. 9 j. ad sfs. cum hauft. falin. camphorat. i. e. fecundum morem julep, camph. p. p. Of lnter?}iittents. §. 49. The latter clafs of paraxyfmatical fevers, (§. 48.) are thofe which leave the pa- tient tolerably well, or without any fever, for a confiderable interval of time, which deno- minates them intermittent \ and that either (i.) quotidian^ if the returns are every day; (2.) tertian, if every other day; or (3.) quartan, if the fi.ts invade every third day from the firfi: : but if the fever returns twnce within any of thofe fpaces, the name of double is added to either of the former. Eat the feafon and complica- tion alfo make a confiderable difference in them ; thofe that come epidemically, and in autumn, being tnuch more ifubborn and degenerative, thanfuch as are merely habitual, andinthefpring. Nor is it nnfrequent for the aguifh matter to fettle itfclf either in the head, lungs or mefen- tery of perfons that are weak, nervous and hippifh ; fo as to form a local or anamolous intermittent ; in which you will have a variety of Of Inter mitt enU. 429 of periodic pains, and other polymorphous fymptoms, that grow worfe by venasfeftions, purges, or any heating medicines 5 but readily yield to the cortex, after they have lain undif^ covered, and infuperable to other methods for half a year running. But in fuch cafes, as Dr. Meadjudicioufly advifes, rhubarb ought to clear the firil paffages, and often join in fome pro- portion with the cortex itfelf ; which, in thefe nervous cafes, is alfo often to be affifted by an addition of myrrh, &c. (V. §. 48, ult.). §. 50. As for the regular uncomplicated in^ termittent (§.49.) it is in effedt an unconnedted chain of fhort continuants, which, like other regular fevers, fuddenly invade, increafe to their height, take their declenfiLon, form a' partial or imperfedt crifis, and make an end all within a few hours ; from an albuminous vif- did, fludl'uating and flowly colledted in the anadomofing capillaries of the arterial fyftem, chiefly in the pulmonary and cutaneous ones, with thofe that belong to the dura mater of the encephalon, .and its vaginal extenfion over the fpinal medalla. There forming a gradually in- creafed refidance to the heart, and to the paf- fage through the lungs, the motion of the blood ilackens with the vs^hole nervous, cuta- neous, bilious, falival, and all other fecretions; except the mucous or vifcid, within the ali- mentary paffages, which are now conhderably increafed. And although we cannot imagine with his imperial worthinefs Dr. Swieren, whom our great Boerhaave defervedly recom- mended to fill his place, as ^Tfculapius for the • day, 430 Of Intermittent^. day, that this extends, even through the mi- nute fabric of the encephalon, into the nerves themfelves ; yet it is highly probable, that it affedts the whole nervous fyftem, after a pe- culiar manner, by its ftimulus, adting on the fine epithelium and fentient fabric of the fto- mach, alimentary and arterial linings, in the fame manner as cold, or any other ftimulus does, by the outward ficin j fince the chill is only apparent or feeming to the patient, while his flefh Is really feveral degrees hotter than in health, to the tefl of a good thermometer, or a fine temperate hand. 2. But whatever its operation maybe in the veffels, whether nervous, fpaftical, opilative, or all together, we obferve in one hour a very great change from it, in a patient that but 20 minutes' before appeared chearful and perfedtly well: for about 15, 18, or 20 minutes, be- fore the fit, he is furprized (i.) by an unde- feriptive qualm, that is foon followed with yawnings, wearinefs, cold-chill, third:, and a ficknefs or load at the ftomach j the breathing labours, and the pulfe falls much, both in its ftrength and magnitude ; the face looks pale, while the nails and fingers ends are livid 3 a heavy pain is felt in the head, back, and loins, with a ftiffnefs in the joints : foon after thefe (2.) a dry or feverifh heat gradually advances throughout the habit, which increafes the head-ach into a fort of giddinefs, while the breathing and pulfe now grow ftronger, the third increafes, and the little urine that is made appears commonly of a clear red, as in the height Of Intermittent^, 43 i height of a continual ardent, to which this part of the fit anfwers : at lafi; (3.) the fever gradually declines and goes off, with more or lefs of a fweat, leaving a forenefs in the habit, a lateritious fediment in the urine, and an in- creafed weaknefs throughout the whole nervous, arterial, and even chylificative fyftems. 3. Here the firfi; ftage or cold-fit (n°. 2.) will hold an hour or more, and the others in proportion, according to the greater quantity and tenacity of the albuminous matter, with its complication, habit of the patient, ingefta, &c. until the blood is fo far colledted in the venal fyftem, that its prefiure makes a ftimulus firong enough upon the right fide of the heart, to break through the pulmonary oppilation ; and then pafiing on to the left, enables this alfo to raife the pulfe and fever fufficient to remove general ftagnations for that time. But as the hot fit (n°. 2. (3.) continues only long enough to digeft a fmall part of the aguifii matter, fuf- ficient to turn the balance only for the prefent, and caufe an imperfed: crifis, therefore the origi- nal fomes foon after recruits, and retires to its pri- mitive quarters, where the blood has lead: mo- mentum j where, by renewing the refiftances again to the heart, and to the fecretory adtion of the encephalon, it caufes a periodical return of the intermittent as before. 4. How far the nervous confent of the fto- mach, always loaded with the agulfli vifcid, may be concerned in caufing the cold-chill and other fymptoms in this diforder, we will not pretend to fay j but that it cannot but be con- fiderable. 432 Of Infermlttents. liderable, feems to follow from an affertlon of the late learned and experienced Dr. Hall, of the Charter-houfe, upon whofe veracity, in the experiment, I believe we may fafely depend : viz. that he had often known a perfcdt cure made in thefe fevers, by the mere infipid, earthy and ligneous remains of the bark, after ail its bitter, refinous and gummy parts had been extracted, by proper menftrua; in which cafe, I believe moft judges will allow, it could not exert any immediate adtion beyond the firft paffages, whofe nervous papilla, with thofe of the fkin, we fee eafily affedled by the minima ftibli, ftimulating them to a vomit or a fweat, while other parts are unaffedled by them. Alfo the power which the faid nervous confent of the ftomach has to induce fleep, and abate the circulation, only by contadl with opiates, agree- able foods, &c. is too well known to dwell upon them. Plence may we draw a reafon for the good effedls of an emetic hauft. ex vin. ippec. or a purgative bole ex rhab. cum cal. by largely excluding the ftimulating fomes, from thefe parts, without which the cortex will often have no effedt. 5. If^cordials and things over-heating are given to young or robuft patients in the cold-lit, the enfuing hot-fit is thereby rendered fo much the more violent, and a delirium or a bad conti- nuant are too often the confequences ; but while third: urges, they may, without danger, be indulged with fage, lavender, or chamomile tea. In fuch perfons, under figns of fullnefs, you will rather have a call for the lancet, in the fpring Of In-f. er mi t tents. 433 fpring feafon ; and if you find a fizy rich blood, repeat it difcretionally : after which, in the au- tumn efpecially, you will generally meet with no fmall benefit from blifters, when an emetic or two have preceded. Afterwards the following bole and draught may be repeated fix or eight times betwixt the fits, with nearly the fame fuccefs as the bark itfelf, as a fubftitute for that celebrated drug, where it is not to be, had : viz. ext. r. helleb. nig. g. myrr. camph. alum, rup. aa 9j half, traumat. q. f. ut f. bol. cum hauft. feq. fumend. viz. aq. menth. vulg. f. tin£t. cinnam. (falis abfynthii vel po- tius) falis diuret. 3^. fyr. e cort. aurant. q. f. ut f. h. horis alternis, tertiis, &c. repetendus. But whether the fever be fubdued by this or by the bark, in order to prevent a return, the coLirfe had beft be repeated once in a week, with an intermediate ufe of a vin. chalib. amar, for a month following. 6. We need not inform thofe who are ac- quainted with praddice, that the celebrated pe- ruvian cortex, which was firft brought into Spain juft a century ago, and for its excellent virtues, both as a febrifuge, a corroborant and an alterative, is well worth (the price it bore in Dr. Lifter’s* days, towards the end of the reign of his fovereign miftrefs Ann, viz.) one guinea an ounce, muft be given to about that quantity, in the interval of time which comes betwixt the fits of an intermittent j as, e. g, a dram, in fome draught or bole, every other hour : or if it be all taken at once, as hath * De Hydrope. .^grot, 7. VoL. II. Ff often 434 Q/* often been the cafe among poor and ignorant folks, it will have not lefs effeft upon the fever, and without inducing any manner of injury whatever. But if it be given in the fit, it has the ill effeds above (n°. 5.) 5 or if you give a purge upon it, the virtues are gone at once, and the fever returns, unlefs you repeat it immediately. Of Inflammation, §.51. We fhould now proceed, conform- able to our plan (§.41.0°. i.), to Xxt. 2 .\,o{ fs 7 npto~ matical fevers^ that fecond fome other antece- dent diforder ; which confequently ought to be enquired after, confidered and treated as the principal, in order to efFed a cure. But fince the neareft and moft general caufe of them is fome irritation, anguifh, pain or inflammation, excited by the diftemper ; and as thefe are all in reality the fame thing, only diverfified by degree and fituation ; therefore it will be firft necef- fary for us to confider inflammation, inclufive of the former, and, in fome meafure, anfwerable to the nature of a local fever. 2. An inflammation, therefore, we define, from its eflhnce rather than effeds, to be an increafed adion of the elaftic and mufcular forces of any particslar artery (§. 3.) urging its contents, with a greater preflure and celerity, through fome or all of its capillaries ; whence follows more or lefs of a preternatural turgef- cence, heat, rednefs, and often throbbing or pain. This, being extended through the whole, or majority of the habit, completes the eflencs of fevers (remark to §. 127.); but more con- fined of Infammatfoni: 43 ^ fined to fome one organ, is the charader of in- flammation : which laft, however, is not to be found in any remarkable degree or extent, without an univerfally quickened circulation, that not unfrequently mounts up to a fympto- matical fever. The effence then of inflamma*- tien, as well as of fever, confifts in a greater arterial preffure, increafing the motion, attri- tion, and heat of the elaftic and cohefive fluids, as well again ft themfelves as againft the fides of the Imall arteries. So mufcular motion, long continued in any particular limb, will fti- mulate the artery into a temporary inflamma- tion ; which, having the retarding capillaries freely pervious, and without any febrile matter, foon ceafes of itfelf by reft. So the blood*s courfe, impeded through the genital arteries, by a preffure on their veins, more diftends them to a greater force, that produces a temporary inflammation, not morbid. 3. The degrees, fymptoms (n°. 2.), and confequences of an inflammation, will there- fore, depend ( i.) on the more or lefs nervous fabric and nature of the arterial diftributions, through the parts affeded (§. 3i.\ (2.) On the nature of the febrile or inflaming matters and their complications (§• 33 - n°. 3.). (3.) On the number of retarding capillaries rendered im- pervious, either by tho'e colleded matters, by erroneous or violent ftrayings of the larger globular juices, or by organical compreffure from the larger diftended trunks, upon their lateral apd lefs refilling capillaries. The num- ber, degrees and complications of all which F f 2 will 436 Of Inflammations. will caufe the blood to pafs into the veins, with a celerity or momentum proportionably in- creafed, through thofe capillaries that are yet pervious ; while thofe that are lefs, or not per- vious, will a6l as fo many cryptas or fecerning duds to the fanguine artery, for colleding and forming the moft cohefive and lluggifh parts into a pleuretic phlogifton, defcribed in our re- mark to Vol. I. p. 147. — (4.) On the denfity (§. 8.) and the fullnefs of the habit (§. 13.) excited by various caufes, and enabling the ar- tery (not overftrained) to ad with greater ela- (lic and mufcular force ; and to urge the denfer blood itfelf with a greater triture and momen- tum. Thus a begun phlegmon in bad habits breeds pain and phlogifton ; and thefe ftimuli increafing, again augment the inflammation, ’till it either difperfes the lentor into the veins, melts it with the impervious capillaries into a laudable cream-like pus, or turns it to a corrupt gangrene j or laftly dries them into a dead feirrhus, that may foon become firft a latent or eneyfted, and then an ulcerated or running cancer, n°. 9, feq. 4. Inflammations of the external parts ap- pear plainly enough, by the effeds 2 ) infe- parablefrom its elfenceor charader j but when it lurks within the vifeera, the eye cannot reach the tumification and rednefs, nor the touch perceive its heat and throbbing j nor even in the liver, heart, lungs, or encephalon, can the patient inform you of its pain. However, in this obfeurity, the hardnefs of the pulfe and the phlogiftic flzynefs of the blood will always 2 be Of Inf animations. 437 be a faithful index of an inward true inflam- mation upon fome of the vifcera j whofe feat you are to determine by the apparent abfence, injury or alteration in theufes or adlions proper to the aifedted organ. Hence we fee the proxi- mate caufe of inflammation is a local fullnefs or accumulation of the blood in fome particu- lar artery, which, prasternaturally diftended, adls with a greater fpring and mufcular fyllole in each pulfation, caufing an increafed heat or triture, in proportion to its own denfity, and that of its included blood. Vid. remark, Vol. I. p. 12 1. 5. But there is an obfervable exception to be made from the foregoing rule (n°. 4.), in what we may call a fuffbcated or depreflfed inflam- mation, extended beyond the tone of the arte- rial forces in the cortex encephali, in the pul- monary arteries, and in the arterial branches of the porta in the liver ; [to which we may add, fuch as are violent in the neck, phauces, larynx, and heart itfelf, with the diaphragm or pleura, and its incumbent mufcles] : for as a moderate degree of inflammation in thefe parts will ex- hibit an index of an inward phlegmon (n°. 4.), by an increafed flow of blood and nervous juices ; fo a much greater degree, by accumulating the matter, and by {hutting up the capillaries (n°. 3. (2.) and (3.), will fo far intercept the courfe of them both, as to afford a weak, foft, and often a trembling or intermitting pulfe. And here, if there be no bilious colliquation (§. 35.0°. 2.), a plentiful blood-letting will fo far relieve the vital fprings oppreifed, as wonderfully to'raife F f 3 the 4.38 Of InfammaUom, the pulfe, anl frequently excite a relieving fw'eat, a purging, a thick urine or a fpitting ; by reftoring to the emunftories, in like manner, their former free and pervious habit. 6. Therefore, in all true inflammations (§. 51.) of any confiderable extent, the greater adlion of the more diflended artery caufes a ftronger compreflure, a fwifter current, and a more violent triture of the cohefive and elaflic blood-globules ; thence a burning heat, a di- ftending pain, and a turgefcence of the cellular and lefs refifting fabric of the leall: veffels, into which the yellow ferum or the red blood are more or lefs tranfpofed,not by a fpontaneous, but a forced flraying out of the fanguine arteries ; whence a yellow, an orange, or a red colour of the parts. Thus the inflammation will in- creafe itfclf to a degree, that may end it one way or the other (n°. 3. ult.) j and at the fame time, according to the extent or degree of it, with the flruflure, fenfibility, and confent of the organ, there will be more or lefs of a fever j a hard quick pulfe j a fliort and laborious breath- ing j and a deep coloured or red urine, with or without a fediment 5 of which the laft pro- portionably denotes concodion and amendment; but, being thin and watry, declaims the worft events. 7. A phlegmon, from caufes not local, is mofl; apt to invade ( i .) thofe parts that have the ifrongefl arterial powers ; therefore thofe of the heart, arterial trunks, lungs, and refpira- tive mufcles ; as they denfify more, and earlier by inceflant adion : (2.) from the lefs extent and Of Inflammatiom. 439 and ftfbdivifion of a fimilar artery from the heart ; for fo the left intercoflals, being fhorter than the right, more generally caufe the pain to be on that fide, more violent in Ihort thick perfons, and in one a thick ficin, dark, opaque, and coarfe habit of body in the vafcules fubdivide more directly, and lefs frequently into retarding capillaries : {3.) from the confiderable refiftance that contiguous bones make to the dilating arte- ries, by which readlion the diftending force is doubled on the oppofite fide of the artery lefs refilled : fo with the ribs, in regard to the in- tercoftalsj the dura mater and pericranium, with regard to the fkull, and fpina dorfi ; the arteries of the perioftia, external and internal, perichondria and thofe fpread on the joints, tendons, and ligaments. Hence the reafon, why pain and other efFerincipal points advanced through the ieftures ; fuch, at leaft, as are to be called upon and examined regularly in the courfe of a diftemper, towards a ready, fafe and fure pradtice. For as the human body is to be readily traverfed, by our enquiry, like Conclufiom. 459 a great city, in divers quarters and ftreets of which we are to pay our vifits, when they are due, either complimental or falutary; fo a pracflitioner, unacquainted with the feats of the public offices, and high or direftive ftrcets of aftion, that are to lead him through the di- ftempered body of his patient, is like a travel- ing gentleman, who, arriving at a metropolis, has therein many old acquaintance, which he muft pafs unconverfed ; becaufe he knows not how to find them, who might have pointed out the beft, ne'areft and fafeft roads to end his journey, with innumerable and collateral ad- vantages. Thus perplexed, for want of know- ing our inward frame as the fubjed;, thofe who are otherwife tolerably well acquainted with the objeds of healing, viz. diftempers and medicines, are often ready to fleer their courfe rather by common index and fet prefcription, than by the true compafs of mechanical reafon and relative obfervation, which ought as much to be pleaded for every procedure in phylic or furgery as in law, by thofe who think their lives even lefs than equivalent to the'r eftates. Yet we fee amiable felf- conceit and idle preju- dice not only fpur many to quack themfelves, but alfo their friends, out of the world, by rendering their cafe, either thro’ delay or ill management, irremediable to all the powers of art or fkill of phyficians. The ingenious fculptor or painter indeed (lands, in general, upon the fame advantageous footing with a good furgeon, as the ufe both of the eye and touch are, to each of them, guides equally fure as fenlible: 460 Conc'ufiom, fenfible : but the phyfician is obliged to wade much farther than the out-lines of fenfe ; his reafonings muft lead him fucceffively through the whole labyrinth of our interior fabric, by tramping backward and forward in filence the philofophic chain, that joins together paft caufes and prefent effedts, prefent appearances and fu- ture events. He muft call out and examine every prefent witnefs of the diftemper, that de- clares, for or againft each indication to be pur- fued j as diredlive of the feveral remedies, ali- ments, and internal medicines to be ufed fuit- ably as to form, time, dofe, combination, and inferior circumftances. Phyfic being, like fculpture or painting, an art that is pradfically imitative of, and coadjutive to nature ; is not therefore lefs a difcretional fcience, to be con- ducled by rules that are not ftridlly mathema- tical, but fubjedt to relaxations, equitable or difcriminative, according to all material circum.- ftances, confidered and allowed for.— A perfon, who, with an air of keen apprehenfton and ready dexterity, fhall inftantaneoufly prefcribe ufual medicines, in the general dofes, and com- mon mixtures or proportions, without regard- ing the material confidcrations hereafter fpeci- fied, is juft like a limner, who applies the com- mon lines, proportions, and features of a hu- man face in general, to repreient each individual countenance, ot which he is to make a copy. However, generals muft preceed as the balls, and particuiars muft be fuperadded lor the ftnifhing, by a growing reafon and experience in all faculties 5 of which that of phyftc, upon the Conclufions. 46 1 the ample, folid, and mechanical plan on which it now ftands, is, from all circumftances con- lidered, abfolutely the moft difficult. We have already, in §. II. of our hiftorical intro- dudlion to the preceding volume, given the moft general and contracted idea of the human frame that we are able. We fliall now only fubjoin a brief phyfiological view of man, as he is the object of life and health, and liable to become the fubjet of difeafes and death, with references to the feveral preceding letures, in which you may fee the particulars more fully explained. Anacephaleojii. §. 55. The preceding letures then have taught us, that man is an animated autemoton, or moft complex natural engine of the hygrau- lic kind, including all the powers of nature, mineral, vegetable, animal and intelletual j employed in the faculties of nutrition, fenfa- tion, mufcular motion, and procreation: which four laft include all the other powers or poffi- bilities of ation throughout the body ; that is to fay, dkiQ faculties of all the organical parts and vifeera are maintained in power or poffibi- lity of aefting, either fucceftively or fimulta- iieoufly, by two forces or fprings of perpetual motion, which, like thofe of a watch, mu- tually influence and excite each other : viz. ( 1 . ) the enrephahn^ and the nervous fyftem pro- duced from it 5 or {2.) the hearty and the i'an- guiferous fyftem produced from it Both thefe mutually excite each other, like the fuzee, or barrel 462 Anacephaleojis. barrel Tprlng ; and the regulator, or pendulum fpring, in a watch ; and together they adluate all the reft of the movement?, that are made up of folid threads and tubes, more or lefs claftic and irritable (le after exerting particular ufes ; fuch as the faiiva, mucus, bile, juices of the ftomach and pancreas; to which add all of the lymphatic glandules, veffels, and the cellular train, whether with or without fat ; fo that we may make a peculiar emundtory to thefe laft, either ( i . ) ufeful^ of ferum, mucus, jelly, fat, oil or wax, for the cellular web and fkins, external or internal 3(2.) recrementitious or perfpiratory ; or (3.) morbid as tranfudations, either through the external cu - ticle, or the internal epithelia (led:. XIV,). T.hb fyftem momentancoufly fufbains and adminifters matter for the imperial courts of fenfe and intel- led:, that fuperintend the whole, by the name of 5. III. The Animal organs, of the ence- phalon and its nervous produtdions ; which, being of the lafc importance to the whole being, and of the moft delicate tender fabric, (as v/ell for reporting the various conditions of our little own, as of the greater external world, to the immaterial foul, as for returning again and exe- cuting her commands accordingly upon the body) are, therefore, lodged in a well defended calfle of obfervation, every way eafily move- able to infped: over her dominions, which are fuftained, moved, and governed by above 5c o capital bones and mufclcs (ledt, XIII.), [which being more the province of the furgeon than phyhcian, are, therefore, the iefs regarded in thefe ledtures] to execute her fenfations, appe- tites, and various motions, whether voluntary, fpontaneous or mixed (ledl. XI. to XXII.). "We have here, for an einundtory, the leafl exhaling VoL. II. H h or 466 Anacephaleojls. or evaporating veffels, which open throughout the whole external and internal furfaces of the body and its feveral cavities ; fo as to be partly diiTipated, and in part refunded to the chyle and blood. Such a variety of organs are there in man, all labouring, at their refpedlive works, alternately or fimult^neoufly with fo much eafe and filence, that the bearer hardly knows that he has them, until pleafure or pain gives him a fenfible admonition of his earthen compa- nions. 6. What we have above advanced concern- ing the human organs and their adlions, enable us to make the following dedudtions : (i.) that Life is a perpetual circumrotation, fegregation, and remixture of the various links or particles that compofe a warm fluid, which we call blood, carried on betwixt two fprings : viz. the heart or vital main fpring (n°. 4, fupra) and the encephalon or animal fpring, with the pro- dudiions of veffels and nerves from them both (n°. fupra), wound up or replenifhed daily by the natural or chylijicathe fprings (11°. 3.). (2.) Thar Health is the aggregate fum of all thofe threefold powers and actions exercifed al- ternately or fimultaneoufly, with a due degree of harmony or confent one to another, within a certain latitude. (3.) That Disease is any difcord, excefs or defedb in the confpiring ac- tions of the folids and fluids, above the faid latitude or balance of health, fo as to caufe any remarkable deflrudion, pain, or uneafinefs throughout the whole, or fome one part ot the aaimai machine. And confequently (4.) s Death Anacephaleojis. 467 Death Is a total abolition or ceffation, both of all thofe adions, and of the faculties or powers from whence they arife j i. e. a flop or reft to all the motions, and the powers gene- rating motions, in the animal engine. (5.) That Aliments are all fubftances, repleat with an oily, infipid or fweetilh mucilage; eafily convertible, by the adions of the body, into the alcalefcent glue, which makes all our fluids and folids, whofe daily wafte re- quires to be repaired by allinition. (6.) That a Medicine, or a morbific matter is any in- gefted fubftance, whofe particles are not thus mutable, by the adions of the body, into the animal nature of its own fluids and folids ^ to both which, being repugnant or ofFenflve, the enemy is driven by their conjund adions, out- ward from the heart, under the condud of the nervous and arterial powers, with the excreted juices of fome emundory, towards which the matter or medicine is faid to tend, operate, and receive a title. (7.) That a Poison is any medicine, morbific matter, or other fubftance, which, being both immutable by the powers of the body into its own animal nature, and alfo deftrudive or invincible to its expulfive forces, remains within the body, whofe organifm it fooner or later deftroys or kills. But cuftom has applied the name chiefly to the ftronger kinds only of thefe, which kill either in a very fmall quantity, or in a. very fliort time. — Four of the preceding confiderations, difeafe, death, medicines, and poifons call us from the phy- flo.logical or natural ftate of man, to that which is 468 Anacephaleojis, is pcenal to him for difobedience to his creator, of which thefe. articles are the proper objedts, under the title of Nosology •, into which we have here made an entry, by the moft frequent and univerfal diftempers; upon the reft of which, we may poflibly give another volume, when time and conveniency may be more fuitable. FINIS. I I Haller 1T51+ 1 V.2 y